Science.gov

Sample records for construction programs c-1

  1. Motion-preserving reduction and fixation of C1 Jefferson fracture using a C1 lateral mass screw construct.

    PubMed

    Jo, Kwang-Wook; Park, Ik-Seong; Hong, Jae Taek

    2011-05-01

    The treatment of C1 Jefferson fractures is controversial. Non-surgical treatment with halo fixation always bears the risk of insufficient healing with further instability and increasing neck pain. However, a C1-2 fusion can markedly decrease the rotatory motion of the neck. The aim of this report is to describe a new treatment for C1 Jefferson fractures. We used open reduction and C1 fixation using a bilateral C1 lateral mass screw construct. The screws were connected with a rod and nuts to reduce lateral spread of the lateral masses. This method is an alternative surgical option for C1 Jefferson fractures in select patients and can maintain important C1-2 joint motion.

  2. Component School Construction Program.

    ERIC Educational Resources Information Center

    New Brunswick Dept. of Economic Growth, Fredericton.

    In 1968, the Province of New Brunswick initiated a three-phase program to provide for elementary school facilities, employing a component systems approach to their construction. This booklet describes briefly the planning and construction of these schools, and provides graphic and photographic records of the construction in progress as well as of…

  3. (+)-Rimocidin Synthetic Studies: Construction of the C(1-27) Aglycone Skeleton

    PubMed Central

    Smith, Amos B.; Foley, Megan A.; Dong, Shuzhi; Orbin, Alia

    2010-01-01

    Assembly of the C(1-27) macrocyclic skeleton of rimocidinolide, the aglycone of (+)-rimocidin (1), has been achieved in convergent fashion. Key features of the synthetic strategy entail application of multicomponent Type 1 Anion Relay Chemistry (ARC), in conjunction with the SN2/SN2' reaction manifolds of vinyl epoxides, both employing 2-susbtituted-1,3-dithianes to construct the C(1-19) carbon backbone. Yamaguchi union of a C(20-27) vinyl borate ester, possessing the all trans triene, with an advanced C(1-19) vinyl iodide followed by macrocyclization via Suzuki-Miyaura cross-coupling completed construction of the C(1-27) rimocidinolide skeleton. PMID:19621880

  4. Computer Programs for Construction

    NASA Technical Reports Server (NTRS)

    1978-01-01

    A NASA computer program aids Hudson Engineering Corporation, Houston, Texas in the design and construction of huge petrochemical processing plants like the one shown, which is located at Ju'aymah, Saud Arabia. The pipes handling the flow of chemicals are subject to a variety of stresses, such as weight and variations in temperature. Hudson Engineering uses a COSMIC piping flexibility analysis computer program to analyze and insure the necessary strength and flexibility of the pipes. This program helps the company realize substantial savings in reduced engineering time.

  5. Constructing Programs from Example Computations.

    ERIC Educational Resources Information Center

    Bierman, A. W.; Krishnaswamy, R.

    This paper describes the construction and implementation of an autoprogramming system. An autoprogrammer is an interactive computer programming system which automatically constructs computer programs from example computations executed by the user. The example calculations are done in a scratch pad fashion at a computer display, and the system…

  6. Language constructs for modular parallel programs

    SciTech Connect

    Foster, I.

    1996-03-01

    We describe programming language constructs that facilitate the application of modular design techniques in parallel programming. These constructs allow us to isolate resource management and processor scheduling decisions from the specification of individual modules, which can themselves encapsulate design decisions concerned with concurrence, communication, process mapping, and data distribution. This approach permits development of libraries of reusable parallel program components and the reuse of these components in different contexts. In particular, alternative mapping strategies can be explored without modifying other aspects of program logic. We describe how these constructs are incorporated in two practical parallel programming languages, PCN and Fortran M. Compilers have been developed for both languages, allowing experimentation in substantial applications.

  7. FELIX construction status and experimental program

    SciTech Connect

    Turner, L.R.; Praeg, W.F.; Knott, M.J.; Lari, R.J.; McGhee, D.G.; Wehrle, R.B.

    1983-01-01

    FELIX (Fusion Electromagnetic Induction Experiment) is an experimental test facility being constructed at Argonne National Laboratory (ANL) for the study of electromagnetic effects in the first wall/blanket/shield (FWBS) systems of fusion reactors. The facility design, construction status, experimental program, instrumentation, and associated computer-code comparisons are described.

  8. Construction Programs (C-1). Department of Defense Budget Fiscal Year 2010

    DTIC Science & Technology

    2009-05-01

    STEAM GENERATION PLANT 1,994 1,994 1,994 1,994...CARDERROCK ENGINEERING MANAGEMENT & LOGISTICS FACILITY 6,980 6,980 6,980 6,980 UNDERGROUND STEAM ...26,098 26,098 NORFOLK HARBOR CHANNEL DREDGING 42,830 42,830 42,830 42,830 REPAIR STEAM

  9. Construction Programs (C-1) Department of Defense Budget for Fiscal Year 1993

    DTIC Science & Technology

    1992-01-29

    DEMILITARIZATIAN FACILITY 11,800f TOOELE ARMY DEPOT 61,200 **ARMY 61,650 AIR FORCE HILL AFB DEPOT WAREHOUSE 16,000 ICBM NON-DESTRUCTIVE INSPECTION BUNKER 2,800...ADD/ALTER STRAT TRNG RANGE TECH OPS FAC 700 CONRAD STRS 700 HAVRE STRS ADD/ALTER STRAT TRNG RANGE TECH OPS FAC 700 HAVRE STRS 700 **AIR FORCE 1,400 ARMY...WHITE SANDS MISSILE RANGE 20,000 ARMY NATIONAL GUARD LAS CRUCES ARMY AVIATION SUPPORT FACIL 1,014 LAS CRUCES 1,014 SANTA FE TRNG SITE, AMMO BUNKER 340

  10. Department of Defense Budget for Fiscal Years 1990 and 1991. Construction Programs (C-1)

    DTIC Science & Technology

    1989-01-09

    NEW YORK NAVY RESERVE AFRC FLOYD BENNETT FIELD, BROOKLYN ELECTRICAL FEEDER IMPROVEMENT 800 AFRC FLOYD BENNETT FIELD, BROOKLYN 800 STEWART...ANX NAVAL SUPPLY CTR MUNICIPAL SEWER CONNECTION 3,300 WILLIAMSBURG CHEATHAM ANX NAVAL SUPPLY CTR 3,300 YORKTOWN NAVAL OPHTHALMIC SPT & TRNG ACT... WILLIAMSBURG CHEATHAM ANX NAVAL SUPPLY CTR SURVEY SUPFORT FACILITY 18,500 WILLIAMSBURG CHEATHAM ANN NAVAL SUPPLY CTR 18,500 YORKTOWN NAVAL WEAPONS

  11. Construction Programs (C-1), Department of Defense Budget, Fiscal Years 2004/2005

    DTIC Science & Technology

    2003-02-01

    RICHARDSON BARRACKS COMPLEX - D STREET PH 3 33,000 33,000 33,000...FORT RICHARDSON AK BARRACKS COMPLEX - D STREET PH 3 33,000 33,000 33,000... D E PA RT ME NT OF DEFE N S E U N ITED STATE S OF A M ER IC A Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the

  12. Construction Programs (C-1), Department of Defense Budget for Fiscal Year 1995

    DTIC Science & Technology

    1994-02-01

    COMPONENTS FACILITY 6.000 CRANE NAVAL SURFACE WARFARE CENTER DIV 6.000 ARMY NATIONAL GUARD FORT WAYNE ARMORY 3.400 ORGANIZATIONAL MAINTENANCE SHOP 800...FORT WAYNE 4.200 AIR NATIONAL GUARD FT WAYNE MAP RUNWAY IMPROVEMENTS 6.039 FT WAYNE MAP 6.039 ",INDIANA 16.239 STATE- 10 FY 1993 MILITARY...4.750 FT WAYNE MAP REPLACE UNDERGROUND FUEL STORAGE TANKS 1.350 FT WAYNE MAP 1.350 **AIR NATIONAL GUARD 6.100 "•INDIANA 39.621 IOWA ARMY NATIONAL GUARD

  13. 40 CFR 264.19 - Construction quality assurance program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Construction quality assurance program... FACILITIES General Facility Standards § 264.19 Construction quality assurance program. (a) CQA program. (1) A construction quality assurance (CQA) program is required for all surface impoundment, waste pile, and...

  14. 40 CFR 265.19 - Construction quality assurance program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Construction quality assurance program..., STORAGE, AND DISPOSAL FACILITIES General Facility Standards § 265.19 Construction quality assurance program. (a) CQA program. (1) A construction quality assurance (CQA) program is required for all...

  15. Epigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?

    PubMed Central

    Stroud, Laura R.; Papandonatos, George D.; Salisbury, Amy L.; Phipps, Maureen G.; Huestis, Marilyn A.; Niaura, Raymond; Padbury, James F.; Marsit, Carmen; Lester, Barry

    2015-01-01

    Epigenetic regulation of the placental glucocorticoid receptor gene (NR3C1) was investigated as a mechanism underlying links between maternal smoking during pregnancy (MSDP) and infant neurobehavior in 45 mother-infant pairs (49% MSDP-exposed; 52% minorities; ages 18-35). The NICU Network Neurobehavioral Scale was administered 7 times over the first postnatal month; methylation of placental NR3C1 was assessed via bisulfite pyrosequencing. Increased placental NR3C1 methylation was associated with increased infant attention and self-regulation, and decreased lethargy and need for examiner soothing over the first postnatal month. A causal steps approach revealed that NR3C1 methylation and MSDP were independently associated with lethargic behavior. Although preliminary, results highlight the importance of epigenetic mechanisms in elucidating pathways to neurobehavioral alterations from MSDP. PMID:26822442

  16. Flexible Language Constructs for Large Parallel Programs

    DOE PAGES

    Rosing, Matt; Schnabel, Robert

    1994-01-01

    The goal of the research described in this article is to develop flexible language constructs for writing large data parallel numerical programs for distributed memory (multiple instruction multiple data [MIMD]) multiprocessors. Previously, several models have been developed to support synchronization and communication. Models for global synchronization include single instruction multiple data (SIMD), single program multiple data (SPMD), and sequential programs annotated with data distribution statements. The two primary models for communication include implicit communication based on shared memory and explicit communication based on messages. None of these models by themselves seem sufficient to permit the natural and efficient expression ofmore » the variety of algorithms that occur in large scientific computations. In this article, we give an overview of a new language that combines many of these programming models in a clean manner. This is done in a modular fashion such that different models can be combined to support large programs. Within a module, the selection of a model depends on the algorithm and its efficiency requirements. In this article, we give an overview of the language and discuss some of the critical implementation details.« less

  17. Flexible language constructs for large parallel programs

    NASA Technical Reports Server (NTRS)

    Rosing, Matthew; Schnabel, Robert

    1993-01-01

    The goal of the research described is to develop flexible language constructs for writing large data parallel numerical programs for distributed memory (MIMD) multiprocessors. Previously, several models have been developed to support synchronization and communication. Models for global synchronization include SIMD (Single Instruction Multiple Data), SPMD (Single Program Multiple Data), and sequential programs annotated with data distribution statements. The two primary models for communication include implicit communication based on shared memory and explicit communication based on messages. None of these models by themselves seem sufficient to permit the natural and efficient expression of the variety of algorithms that occur in large scientific computations. An overview of a new language that combines many of these programming models in a clean manner is given. This is done in a modular fashion such that different models can be combined to support large programs. Within a module, the selection of a model depends on the algorithm and its efficiency requirements. An overview of the language and discussion of some of the critical implementation details is given.

  18. 40 CFR 35.903 - Summary of construction grant program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.903 Summary of construction grant program. (a) The construction of federally financed waste... States to provide for, encourage and assist public participation in the Construction Grants Program....

  19. 40 CFR 35.903 - Summary of construction grant program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.903 Summary of construction grant program. (a) The construction of federally financed waste... States to provide for, encourage and assist public participation in the Construction Grants Program....

  20. Epigenetic Regulation of Placental "NR3C1": Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?

    ERIC Educational Resources Information Center

    Stroud, Laura R.; Papandonatos, George D.; Salisbury, Amy L.; Phipps, Maureen G.; Huestis, Marilyn A.; Niaura, Raymond; Padbury, James F.; Marsit, Carmen J.; Lester, Barry M.

    2016-01-01

    Epigenetic regulation of the placental glucocorticoid receptor gene ("NR3C1") was investigated as a mechanism underlying links between maternal smoking during pregnancy (MSDP) and infant neurobehavior in 45 mother-infant pairs (49% MSDP-exposed; 52% minorities; ages 18-35). The Neonatal Intensive Care Unit (NICU) Network Neurobehavioral…

  1. Alberta's Funding Program for School Construction.

    ERIC Educational Resources Information Center

    Kulba, John W.; Hathaway, Warren E.

    1983-01-01

    A capital funding plan was introduced in Alberta in 1979 to more effectively control school construction and ensure that provincial priorities were being achieved. The formula includes factors to adjust for financial equity, district utilization of space, approved areas, and changes in construction costs. (MLF)

  2. Construction safety program for the National Ignition Facility

    SciTech Connect

    Cerruti, S.J.

    1997-06-26

    The Construction Safety Program (CSP) for NIF sets forth the responsibilities, guidelines, rules, policies and regulations for all workers involved in the construction, special equipment installation, acceptance testing, and initial activation and operation of NIF at LLNL during the construction period of NIF.

  3. Construction safety program for the National Ignition Facility

    SciTech Connect

    Cerruti, S.J.

    1997-01-01

    The Construction Safety Program (CSP) for NIF sets forth the responsibilities, guidelines, rules, policies and regulations for all workers involved in the construction, special equipment installation, acceptance testing, and initial activation and operation of NIF at LLNL during the construction period of NIF. During this period, all workers are required to implement measures to create a universal awareness which promotes safe practice at the work site, and which will achieve NIF`s management objectives in preventing accidents and illnesses. Construction safety for NIF is predicated on everyone performing their jobs in a manner which prevents job-related disabling injuries and illnesses. The CSP outlines the minimum environment, safety, and health (ES&H) standards, LLNL policies and the Construction Industry Institute (CII) Zero Injury Techniques requirements that all workers at the NIF construction site shall adhere to during the construction period of NIF. It identifies the safety requirements which the NIF organizational Elements, construction contractors and construction subcontractors must include in their safety plans for the construction period of NIF, and presents safety protocols and guidelines which workers shall follow to assure a safe and healthful work environment. The CSP also identifies the ES&H responsibilities of LLNL employees, non-LLNL employees, construction contractors, construction subcontractors, and various levels of management within the NIF Program at LLNL. In addition, the CSP contains the responsibilities and functions of ES&H support organizations and administrative groups, and describes their interactions with the NIF Program.

  4. Construction Pre-Apprenticeship Programs: Results from a National Survey

    ERIC Educational Resources Information Center

    Conway, Maureen; Gerber, Allison

    2009-01-01

    This publication shares findings from a WSI-conducted survey of pre-apprenticeship programs in the construction trades. Based on responses from 260 programs nationwide, the report presents information about program size, services offered, populations served, funding sources, and successes and challenges in placing trainees in apprenticeships or…

  5. Constructing Effective Corporate Adventure Training Programs.

    ERIC Educational Resources Information Center

    Gass, Michael; And Others

    1992-01-01

    Effective corporate adventure training programs: (1) develop parallel structures between the adventure experience and the workplace (context); (2) consider how the learning will address a company's future needs (continuity); (3) provide learners with valid information and feedback on their actions (consequences); and (4) create physically and…

  6. 25 CFR 1000.254 - May a Tribe/Consortium reallocate funds from a construction program to a non-construction program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false May a Tribe/Consortium reallocate funds from a... Tribe/Consortium reallocate funds from a construction program to a non-construction program? No, a Tribe/Consortium may not reallocate funds from a construction program to a non-construction program...

  7. 25 CFR 1000.254 - May a Tribe/Consortium reallocate funds from a construction program to a non-construction program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false May a Tribe/Consortium reallocate funds from a... Tribe/Consortium reallocate funds from a construction program to a non-construction program? No, a Tribe/Consortium may not reallocate funds from a construction program to a non-construction program...

  8. 25 CFR 1000.254 - May a Tribe/Consortium reallocate funds from a construction program to a non-construction program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false May a Tribe/Consortium reallocate funds from a... Tribe/Consortium reallocate funds from a construction program to a non-construction program? No, a Tribe/Consortium may not reallocate funds from a construction program to a non-construction program...

  9. 25 CFR 1000.254 - May a Tribe/Consortium reallocate funds from a construction program to a non-construction program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false May a Tribe/Consortium reallocate funds from a... Tribe/Consortium reallocate funds from a construction program to a non-construction program? No, a Tribe/Consortium may not reallocate funds from a construction program to a non-construction program...

  10. Public School Construction Program. Administrative Procedures Guide. Revised.

    ERIC Educational Resources Information Center

    Maryland State Interagency Committee on School Construction, Baltimore.

    The State of Maryland has published this guide that provides State and local personnel, architects, and governmental officials with the method of operation and administration of the State's Public School Construction Program. The material is arranged in sequential order and follows a project from inception through design, construction, and…

  11. 40 CFR 35.903 - Summary of construction grant program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Summary of construction grant program. 35.903 Section 35.903 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER... developed urban areas should be included as part of the development costs of the new construction in...

  12. Guidelines for Implementing State Skill Standards Certificate Program in Construction.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Workforce Development, Madison.

    This packet contains guidelines, a student competency checklist, and student evaluation sheet for use in a Wisconsin school-to-work state skill standards certificate program in construction. The guidelines provide a planning resource for implementing the program, which was created in partnership with unions, employers, the state Department of…

  13. Effects of a Combined Aerobic and Resistance Exercise Program on C1q/TNF-Related Protein-3 (CTRP-3) and CTRP-5 Levels

    PubMed Central

    Choi, Hae Yoon; Park, Ji Woo; Lee, Namseok; Hwang, Soon Young; Cho, Geum Ju; Hong, Ho Cheol; Yoo, Hye Jin; Hwang, Taek Geun; Kim, Seon Mi; Baik, Sei Hyun; Park, Kyong Soo; Youn, Byung-Soo; Choi, Kyung Mook

    2013-01-01

    OBJECTIVE To examine the effect of a combined exercise program on C1q/tumor necrosis factor-related protein (CTRP) 3 and CTRP-5 levels and novel adiponectin paralogs suggested to be links between metabolism and inflammation and to evaluate sex differences and association with cardiometabolic risk factors in humans with use of a newly developed ELISA. RESEARCH DESIGN AND METHODS This cross-sectional study explored the implications of CTRP-3 and CTRP-5 on cardiometabolic parameters in 453 nondiabetic Korean adults. In addition, we evaluated the impact of a 3-month combined exercise program on CTRP-3 and CTRP-5 levels in 76 obese women. The exercise program consisted of 45 min of aerobic exercise at an intensity of 60–75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times per week. RESULTS Both CTRP-3 and CTRP-5 concentrations were significantly higher in women (P < 0.001) than in men (P = 0.030). In a multiple stepwise regression analysis, CTRP-3 levels were independently associated with age, sex, and triglyceride, LDL cholesterol, adiponectin, and retinol-binding protein 4 (RBP4) levels (R2 = 0.182). After 3 months of a combined exercise program, cardiometabolic risk factors, including components of metabolic syndrome, insulin resistance, and RBP4 levels, decreased significantly. In particular, CTRP-3 levels decreased significantly (median [interquartile range] 444.3 [373.8–535.0] to 374.4 [297.2–435.9], P < 0.001), whereas CTRP-5 levels were slightly increased (34.1 [28.6–44.3] to 38.4 [29.8–55.1], P = 0.048). CONCLUSIONS A 3-month combined exercise program significantly decreased CTRP-3 levels and modestly increased CTRP-5 levels in obese Korean women. PMID:23780948

  14. The NIOSH Construction Program: research to practice, impact, and developing a National Construction Agenda.

    PubMed

    Gillen, Matt

    2010-06-01

    The U.S. National Institute for Occupational Safety and Health (NIOSH) conducts research to improve and protect the health and safety of workers. This paper describes the experience of the NIOSH Construction Program with two recent program planning initiatives intended to improve the program: (a) an independent external review of work over the past decade and (b) the development of strategic goals organized into a "National Construction Agenda" to guide a decade of future work. These goals, developed with input from construction industry stakeholders and researchers, are a part of the NIOSH National Occupational Research Agenda (NORA) initiative. The NORA goals are intended to provide an ambitious set of goals for all construction stakeholders to work together on. Both efforts relate to insuring the relevance and impact of research, reflecting an emerging policy perspective that research programs should be judged not just by the quality and quantity of science produced, but by the industry impact and tangible benefit resulting from the research. This paper describes how views on research planning have evolved to incorporate lessons learned about how research leads to improved safety and health for workers. It also describes the process used to develop the goals and the resulting strategic and intermediate goals that comprise the National Construction Agenda.

  15. Citizens Utilities Company's successful residential new construction market transformation program

    SciTech Connect

    Caulfield, T.O.; Shepherd, M.A.

    1998-07-01

    Citizens Utilities Company, Arizona Electric Division (CUC/AED) fielded a Residential New Construction Program (RNC) in the forth quarter of 1994 that had been designed from conception as a market transformation program. The CUC RNC Program encouraged builders to adopt energy efficient building practices for new homes by supplying builders estimates of energy savings, supplying inspections services to assist builders in applying energy efficient building practices while verifying compliance, and posting and promoting the home as energy efficient during the sales period. Measures generally required to qualify for the program were R-38 ceiling insulation, R-21 wall insulation, polysealing of all infiltration gaps during construction, well sealed air-conditioning ducts, and an air conditioner Seasonal Energy Efficiency Rating (SEER) of 11.0 or greater. In less than two years the program achieved over 17% market penetration without offering rebates to builders. This paper reviews the design of the program, including a discussion of the features felt to be primarily responsible for its success. It reviews the levels of penetration achieved, free-ridership, spillover, and market barriers encountered. Finally it proposes improvements to the program designed to carry it the next step toward a self-sustaining market transformation program.

  16. Development of a safety communication and recognition program for construction.

    PubMed

    Sparer, Emily H; Herrick, Robert F; Dennerlein, Jack T

    2015-05-01

    Leading-indicator-based (e.g., hazard recognition) incentive programs provide an alternative to controversial lagging-indicator-based (e.g., injury rates) programs. We designed a leading-indicator-based safety communication and recognition program that incentivized safe working conditions. The program was piloted for two months on a commercial construction worksite and then redesigned using qualitative interview and focus group data from management and workers. We then ran the redesigned program for six months on the same worksite. Foremen received detailed weekly feedback from safety inspections, and posters displayed worksite and subcontractor safety scores. In the final program design, the whole site, not individual subcontractors, was the unit of analysis and recognition. This received high levels of acceptance from workers, who noted increased levels of site unity and team-building. This pilot program showed that construction workers value solidarity with others on site, demonstrating the importance of health and safety programs that engage all workers through a reliable and consistent communication infrastructure.

  17. 40 CFR 264.19 - Construction quality assurance program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... 264.301. (2) The CQA program shall include test fills for compacted soil liners, using the same... fill, where data are sufficient to show that a constructed soil liner will meet the...

  18. 40 CFR 264.19 - Construction quality assurance program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... 264.301. (2) The CQA program shall include test fills for compacted soil liners, using the same... fill, where data are sufficient to show that a constructed soil liner will meet the...

  19. 40 CFR 264.19 - Construction quality assurance program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... 264.301. (2) The CQA program shall include test fills for compacted soil liners, using the same... fill, where data are sufficient to show that a constructed soil liner will meet the...

  20. 40 CFR 264.19 - Construction quality assurance program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... 264.301. (2) The CQA program shall include test fills for compacted soil liners, using the same... fill, where data are sufficient to show that a constructed soil liner will meet the...

  1. Language constructs and runtime systems for compositional parallel programming

    SciTech Connect

    Foster, I.; Kesselman, C.

    1995-03-01

    In task-parallel programs, diverse activities can take place concurrently, and communication and synchronization patterns are complex and not easily predictable. Previous work has identified compositionality as an important design principle for task-parallel programs. In this paper, we discuss alternative approaches to the realization of this principle. We first provide a review and critical analysis of Strand, an early compositional programming language. We examine the strengths of the Strand approach and also its weaknesses, which we attribute primarily to the use of a specialized language. Then, we present an alternative programming language framework that overcomes these weaknesses. This framework uses simple extensions to existing sequential languages (C++ and Fortran) and a common runtime system to provide a basis for the construction of large, task-parallel programs. We also discuss the runtime system techniques required to support these languages on parallel and distributed computer systems.

  2. 42 CFR 137.275 - May Self-Governance Tribes include IHS construction programs in a construction project agreement...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false May Self-Governance Tribes include IHS construction... OF HEALTH AND HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Purpose and Scope § 137.275 May Self... agreement? Yes, Self-Governance Tribes may choose to assume construction programs in a construction...

  3. Automating construction through the use of robotics and Graphical Programming

    SciTech Connect

    McDonald, M.J.; Palmquist, R.D.

    1993-08-01

    Sandia has developed an advanced operational control system approach, called Graphical Programming, to design and operate robot systems in unstructured environments. This Graphical Programming approach produces robot systems that are faster to develop and use, safer in operation, and cheaper overall than altemative teleoperation or autonomous robot control systems. This approach uses 3-D visualization and simulation software with intuitive operator interfaces for the programming and control of complex robotic systems. Supervisor software modules allow an operator to command and simulate complex tasks in a graphic preview mode and, when acceptable, command the actual robots and monitor their motions with the graphic system. Graphical Programming Supervisors maintain registration with the real world and allow the robot to perform tasks that cannot be accurately represented with models alone by using a combination of model and sensor-based control. All of these capabilities when combined result in a flexible system which is readily able to meet the demands called for in construction automation. This paper describes the Graphical Programming approach, several example control systems that use Graphical Programming, key features necessary for implementing successful Graphical Programming systems, and specific examples of applying these systems to robotic operations.

  4. 25 CFR 1000.254 - May a Tribe/Consortium reallocate funds from a construction program to a non-construction program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... construction program to a non-construction program? 1000.254 Section 1000.254 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.254 May...

  5. 32 CFR 1906.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... INTELLIGENCE AGENCY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE CENTRAL INTELLIGENCE AGENCY § 1906.151 Program accessibility: New construction...

  6. 32 CFR 1906.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... INTELLIGENCE AGENCY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE CENTRAL INTELLIGENCE AGENCY § 1906.151 Program accessibility: New construction...

  7. 32 CFR 1906.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... INTELLIGENCE AGENCY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE CENTRAL INTELLIGENCE AGENCY § 1906.151 Program accessibility: New construction...

  8. 32 CFR 1906.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... INTELLIGENCE AGENCY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE CENTRAL INTELLIGENCE AGENCY § 1906.151 Program accessibility: New construction...

  9. 32 CFR 1906.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INTELLIGENCE AGENCY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE CENTRAL INTELLIGENCE AGENCY § 1906.151 Program accessibility: New construction...

  10. Better Space Construction Decisions by Instructional Program Simulation Utilizing the Generalized Academic Simulation Programs.

    ERIC Educational Resources Information Center

    Apker, Wesley

    This school district utilized the generalized academic simulation programs (GASP) to assist in making decisions regarding the kinds of facilities that should be constructed at Pilchuck Senior High School. Modular scheduling was one of the basic educational parameters used in determining the number and type of facilities needed. The objectives of…

  11. System Analysis in Instructional Programming: The Initial Phases of the Program Construction Process.

    ERIC Educational Resources Information Center

    Bjerstedt, Ake

    A three-volume series describes the construction of a self-instructional system as a work process with three main phases: system analysis, system synthesis, and system modification and evaluation. After an introductory discussion of some basic principles of instructional programing, this first volume focuses on the system analysis phase,…

  12. Feasibility of home infusion and self-administration of nanofiltered C1 esterase inhibitor for routine prophylaxis in patients with hereditary angioedema and characterization of a training and support program.

    PubMed

    Gregory, Cherylann; Landmesser, Ladonna M; Corrigan, Larry; Mariano, David

    2014-01-01

    Hereditary angioedema (HAE) is a rare, chronic disease of C1 inhibitor deficiency. Study researchers evaluated the prevalence of home and self-administration of nanofiltered, human-derived C1 esterase inhibitor infusions and the implementation of a nursing training and support program. Home administration rate increased from 49.0% to 75.8%. The percentage who self-administered increased from 20.3% to 43.9%. Doses per week averaged 1.85 at home compared with 1.40 in infusion centers and physicians' offices. Patients required an average of 5 visits to be trained. Self-administration is a viable, feasible option in the management of HAE, which is facilitated by a nurse-managed training and support program.

  13. Corporate Mentors and Undergraduate Students: A Qualitative Study of the Advancing Women in Construction Mentorship Program

    ERIC Educational Resources Information Center

    Eicher, Matthew

    2013-01-01

    In a conscious effort to combat the low enrollment of women in construction management, a program was created to retain women through a mentorship program--Advancing Women in Construction. A qualitative analysis, facilitated through a grounded theory approach, sought to understand if the program was indeed successful, and what value did the…

  14. 45 CFR 606.52 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SCIENCE FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL SCIENCE FOUNDATION § 606.52 Program accessibility: New construction and... 45 Public Welfare 3 2010-10-01 2010-10-01 false Program accessibility: New construction...

  15. 1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells

    SciTech Connect

    Asare, Nana Landvik, Nina E.; Lagadic-Gossmann, Dominique; Rissel, Mary; Tekpli, Xavier; Ask, Kjetil; Lag, Marit; Holme, Jorn A.

    2008-07-15

    Mechanistic studies of nitro-PAHs (polycyclic aromatic hydrocarbons) of interest might help elucidate which chemical characteristics are most important in eliciting toxic effects. 1-Nitropyrene (1-NP) is the predominant nitrated PAH emitted in diesel exhaust. 1-NP-exposed Hepa1c1c7 cells exhibited marked changes in cellular morphology, decreased proliferation and different forms of cell death. A dramatic increase in cytoplasmic vacuolization was observed already after 6 h of exposure and the cells started to round up at 12 h. The rate of cell proliferation was markedly reduced at 24 h and apoptotic as well as propidium iodide (PI)-positive cells appeared. Electron microscopic examination revealed that the vacuolization was partly due to mitochondria swelling. The caspase inhibitor Z-VAD-FMK inhibited only the apoptotic cell death and Nec-1 (an inhibitor of necroptosis) exhibited no inhibitory effects on either cell death or vacuolization. In contrast, cycloheximide markedly reduced both the number of apoptotic and PI-positive cells as well as the cytoplasmic vacuolization, suggesting that 1-NP induced paraptotic cell death. All the MAPKs; ERK1/2, p38 and JNK, appear to be involved in the death process since marked activation was observed upon 1-NP exposure, and their inhibitors partly reduced the induced cell death. The ERK1/2 inhibitor PD 98057 completely blocked the induced vacuolization, whereas the other MAPKs inhibitors only had minor effects on this process. These findings suggest that 1-NP may cause apoptosis and paraptosis. In contrast, the corresponding amine (1-aminopyrene) elicited only minor apoptotic and necrotic cell death, and cells with characteristics typical of paraptosis were absent.

  16. Extravehicular Crewman Work System (ECWS) study program. Volume 2: Construction

    NASA Technical Reports Server (NTRS)

    Wilde, R. C.

    1980-01-01

    The construction portion of the Extravehicular Crewman Work System Study defines the requirements and selects the concepts for the crewman work system required to support the construction of large structures in space.

  17. New Tactics for Building: Experience/Analysis/Recommendations from the Detroit Public Schools Construction Systems Program.

    ERIC Educational Resources Information Center

    Cleland, Wallace B., Ed.

    This study is focused on organizational and procedural aspects of the Construction Systems Program (CSP), a developmental/demonstration project. The report is derived principally from practical observations by 42 active participants (architects, engineers, contractors, construction managers, owner's staff) in a four-school pilot program. Also…

  18. 6 CFR 15.51 - Program accessibility; new construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Program accessibility; new construction and alterations. 15.51 Section 15.51 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY... DEPARTMENT OF HOMELAND SECURITY § 15.51 Program accessibility; new construction and alterations....

  19. 6 CFR 15.51 - Program accessibility; new construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Program accessibility; new construction and alterations. 15.51 Section 15.51 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY... DEPARTMENT OF HOMELAND SECURITY § 15.51 Program accessibility; new construction and alterations....

  20. 40 CFR 12.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Program accessibility: New construction and alterations. 12.151 Section 12.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... ENVIRONMENTAL PROTECTION AGENCY § 12.151 Program accessibility: New construction and alterations. Each...

  1. 40 CFR 12.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Program accessibility: New construction and alterations. 12.151 Section 12.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... ENVIRONMENTAL PROTECTION AGENCY § 12.151 Program accessibility: New construction and alterations. Each...

  2. 40 CFR 12.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Program accessibility: New construction and alterations. 12.151 Section 12.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... ENVIRONMENTAL PROTECTION AGENCY § 12.151 Program accessibility: New construction and alterations. Each...

  3. 40 CFR 12.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Program accessibility: New construction and alterations. 12.151 Section 12.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... ENVIRONMENTAL PROTECTION AGENCY § 12.151 Program accessibility: New construction and alterations. Each...

  4. Adults' Perceptions of Knowledge Construction as Participants in Nonformal World Affairs Programs: An Interpretive Study

    ERIC Educational Resources Information Center

    Yelich Biniecki, Susan M.

    2015-01-01

    The purpose of this interpretive research study was to explore how adult learners perceive they construct knowledge in connection to their participation in nonformal world affairs programs. The study context involved the exploration of 12 adult learners' perceptions of their knowledge construction as participants in world affairs programs held in…

  5. A Solid Foundation: Key Capacities of Construction Pre-Apprenticeship Programs

    ERIC Educational Resources Information Center

    Helmer, Matt; Blair, Amy; Gerber, Allison

    2012-01-01

    This publication shares research from site visits conducted to construction pre-apprenticeship programs in Baltimore, Hartford, Milwaukee and Portland (OR). Findings from the site visits, which included interviews and focus groups with pre-apprenticeship program staff, public officials, philanthropic leaders, construction industry leaders and…

  6. The demise of residential new construction programs: Is there life after death?

    SciTech Connect

    Vine, E.L.

    1995-05-01

    Based on an evaluation of 10 residential new construction programs sponsored by investor-owned utilities in the US, the authors find that many of these programs are in dire straits and are in danger of being discontinued because they are not cost-effective. They believe that the cost-effectiveness of residential new construction programs can be improved by: (1) reducing program marketing costs and developing more effective marketing strategies; (2) promoting technologies and advanced building design practices significantly exceeding state and federal standards; (3) recognizing these programs` role in increasing compliance by participants with existing state building codes; and (4) obtaining an energy-savings credit for program spillover (market transformation) impacts. The issues involved in evaluating residential new construction programs will be challenging as evaluators attempt to quantify the savings from program spillover.

  7. Labor productivity in heavy construction: impact on synfuels program employment

    SciTech Connect

    Kusterer, K.C.

    1980-06-01

    This study focuses on variations in labor productivity in the heavy construction industry. Productivity is one of a number of factors likely to affect the speed and cost of constructing a synthetic fuels plant. The findings of this study are presented with reference to synthetic fuels plants, but they are relevant to other large energy facilities as well. The data were gathered through a detailed literature search and extensive in-depth interviews with consultants in heavy industrial construction, union officials, and management. In this manner the most important determinants of labor productivity were identified and ranked in terms of relative significance. The type of project under construction is the most important factor affecting the productivity of heavy construction labor. Projects characterized by the utility work syndrome are large, complex, relatively unique, highly regulated, and have cost-plus contracts and tight deadlines. Such projects generally have lower-than-average levels of labor productivity. Labor productivity is also lowered by worker and management morale problems, due to delays and design changes, and by high levels of unemployment among construction workers. Finally, boom town conditions, caused by workers moving to live near large projects located in rural areas, also are likely to result in below-average labor productivity.Synthetic fuels plants are likely to have a number of these identified characteristics. Consequently, the findings suggest that labor productivity may well be a problem for the timely development of an economically competitive synthetic fuels industry.

  8. Utility residential new construction programs: Going beyond the code. A report from the Database on Energy Efficiency Programs (DEEP) Project

    SciTech Connect

    Vine, E.

    1995-08-01

    Based on an evaluation of 10 residential new construction programs, primarily sponsored by investor-owned utilities in the United States, we find that many of these programs are in dire straits and are in danger of being discontinued because current inclusion of only direct program effects leads to the conclusion that they are not cost-effective. We believe that the cost-effectiveness of residential new construction programs can be improved by: (1) promoting technologies and advanced building design practices that significantly exceed state and federal standards; (2) reducing program marketing costs and developing more effective marketing strategies; (3) recognizing the role of these programs in increasing compliance with existing state building codes; and (4) allowing utilities to obtain an ``energy-savings credit`` from utility regulators for program spillover (market transformation) impacts. Utilities can also leverage their resources in seizing these opportunities by forming strong and trusting partnerships with the building community and with local and state government.

  9. An Approach to Effortless Construction of Program Animations

    ERIC Educational Resources Information Center

    Velazquez-Iturbide, J. Angel; Pareja-Flores, Cristobal; Urquiza-Fuentes, Jaime

    2008-01-01

    Program animation systems have not been as widely adopted by computer science educators as we might expect from the firm belief that they can help in enhancing computer science education. One of the most notable obstacles to their adoption is the considerable effort that the production of program animations represents for the instructor. We…

  10. 45 CFR 2301.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) ARCTIC RESEARCH COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES ARCTIC RESEARCH COMMISSION § 2301.151 Program accessibility: New... 45 Public Welfare 4 2011-10-01 2011-10-01 false Program accessibility: New construction...

  11. "It's All Up to You": How Welfare-to-Work Educational Programs Construct Workforce Success

    ERIC Educational Resources Information Center

    Sandlin, Jennifer A.

    2004-01-01

    This article discusses how two welfare education programs construct workforce success. Discourse about success in these programs falls into two basic camps: an individual-based self-motivation perspective and an external, structural, socioeconomic perspective. Although the individualistic perspective adhered to by the programs came into conflict…

  12. Financial Awareness Education with Apprentices in the Australian Construction Industry: Program Evaluation

    ERIC Educational Resources Information Center

    Du Plessis, Karin; Green, Emma

    2013-01-01

    A financial awareness education program was implemented with construction industry apprentices in Victoria, Australia. The program included face-to-face delivery of education around a range of financial management issues that apprentices face as they begin their apprenticeship. The paper reports on an evaluation of the program, which included…

  13. Algorithm for constructing the programmed motion of a bounding vehicle for the flight phase

    NASA Technical Reports Server (NTRS)

    Lapshin, V. V.

    1979-01-01

    The construction of the programmed motion of a multileg bounding vehicle in the flight was studied. An algorithm is given for solving the boundary value problem for constructing this programmed motion. If the motion is shown to be symmetrical, a simplified use of the algorithm can be applied. A method is proposed for nonimpact of the legs during lift-off of the vehicle, and for softness at touchdown. Tables are utilized to construct this programmed motion over a broad set of standard motion conditions.

  14. 40 CFR 265.19 - Construction quality assurance program.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... fills for compacted soil liners, using the same compaction methods as in the full-scale unit, to ensure... requirement is waived where data are sufficient to show that a constructed soil liner meets the...

  15. 40 CFR 265.19 - Construction quality assurance program.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... fills for compacted soil liners, using the same compaction methods as in the full-scale unit, to ensure... requirement is waived where data are sufficient to show that a constructed soil liner meets the...

  16. 40 CFR 265.19 - Construction quality assurance program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... fills for compacted soil liners, using the same compaction methods as in the full-scale unit, to ensure... requirement is waived where data are sufficient to show that a constructed soil liner meets the...

  17. 40 CFR 265.19 - Construction quality assurance program.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... components, where applicable: (i) Foundations; (ii) Dikes; (iii) Low-permeability soil liners; (iv... fills for compacted soil liners, using the same compaction methods as in the full-scale unit, to ensure... requirement is waived where data are sufficient to show that a constructed soil liner meets the...

  18. Constructing a Family Literacy Program: Challenges and Successes

    ERIC Educational Resources Information Center

    Jay, Jenny; Rohl, Mary

    2005-01-01

    This paper describes a family literacy project that involved parents whose children were attending a pre-school centre in a low socio-economic suburb of Perth, Western Australia. A formative experimental design was used to examine the home literacy practices of the families as described by the parents, and to construct a series of workshops. The…

  19. 40 CFR 35.903 - Summary of construction grant program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... “treatment works segment” (see § 35.905) of construction within a step. In the case of step 2=3 grant awards... written approval of a “plan of study” accompanied by a reservation of funds (see § 35.925-18 and...; see § 35.925-13. (m) The approval of a plan of study for step 1, a facilities plan, or award of...

  20. Automated Construction Management System (ACMS). Volume 2. Program Documentation.

    DTIC Science & Technology

    1984-06-01

    fe -e !t !a’.*I - . I’ q . .% % .. -S C .. .. .. .. .. .. .. . .. . 19 BAC UP CM . . oo o .. .. s.. .. .. . o.. s .. .. . . . . 197 WP . M s . . . . .s...USE RETURN * * *END BACKUP.CMD 26**. *% A C M S Ver. 84.0 ’ * USA-CERL PROGRAM: BILL.CMD " * DESCRIPTION: This program allows the user to set up ...11,0 SAY "Schedules Included: " ?? " <Type CTR-Q to abort>" SELECT SECOND STORE 12 TO row STORE 0 TO col * up to 80 schedules can be displayed on

  1. 78 FR 25062 - Program for Construction, Renovation, Repair or Expansion of Public Schools Located on Military...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... on Military Installations AGENCY: Office of Economic Adjustment (OEA), Department of Defense (DoD... program to construct, renovate, repair, or expand elementary and ] secondary public schools on military... Schools Located on Military Installations. Announcement Type: Federal Funding Opportunity. Catalog...

  2. Constructing a conflict resolution program for health care.

    PubMed

    Porter-O'Grady, Tim

    2004-01-01

    Resolving conflict throughout organizations requires a programmatic infrastructure and a committed management team. Leaders must recognize the need to approach conflict by building a format for learning, creating and managing an effective conflict management program. Careful attention to the elements of design and the stages of development can make all the difference in building a sustainable and useful conflict management approach.

  3. Construction safety program for the National Ignition Facility, Appendix B

    SciTech Connect

    Cerruti, S.J.

    1997-06-26

    This Appendix contains material from the LLNL Health and Safety Manual as listed below. For sections not included in this list, please refer to the Manual itself. The areas covered are: asbestos, lead, fire prevention, lockout, and tag program confined space traffic safety.

  4. 41 CFR 51-10.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Program accessibility: New construction and alterations. 51-10.151 Section 51-10.151 Public Contracts and Property Management... altered by, on behalf of, or for the use of the agency shall be designed, constructed, or altered so as...

  5. 41 CFR 51-10.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Program accessibility: New construction and alterations. 51-10.151 Section 51-10.151 Public Contracts and Property Management... altered by, on behalf of, or for the use of the agency shall be designed, constructed, or altered so as...

  6. 25 CFR 1000.255 - May a Tribe/Consortium reallocate funds among construction programs?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false May a Tribe/Consortium reallocate funds among... INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.255 May a Tribe/Consortium reallocate funds among construction programs? Yes, a Tribe/Consortium may reallocate funds among...

  7. 25 CFR 1000.255 - May a Tribe/Consortium reallocate funds among construction programs?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false May a Tribe/Consortium reallocate funds among... INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.255 May a Tribe/Consortium reallocate funds among construction programs? Yes, a Tribe/Consortium may reallocate funds among...

  8. 25 CFR 1000.255 - May a Tribe/Consortium reallocate funds among construction programs?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false May a Tribe/Consortium reallocate funds among... INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.255 May a Tribe/Consortium reallocate funds among construction programs? Yes, a Tribe/Consortium may reallocate funds among...

  9. 25 CFR 1000.255 - May a Tribe/Consortium reallocate funds among construction programs?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false May a Tribe/Consortium reallocate funds among... INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.255 May a Tribe/Consortium reallocate funds among construction programs? Yes, a Tribe/Consortium may reallocate funds among...

  10. RECOMMENDED FOUNDATION FILL MATERIALS CONSTRUCTION STANDARD OF THE FLORIDA RADON RESEARCH PROGRAM

    EPA Science Inventory

    The report summarizes the technical basis for a recommended foundation fill materials standard for new construction houses in Florida. he radon-control construction standard was developed by the Florida Radon Research Program (FRRP). ill material standards are formulated for: (1)...

  11. 25 CFR 1000.255 - May a Tribe/Consortium reallocate funds among construction programs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... construction programs? 1000.255 Section 1000.255 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Construction § 1000.255 May a Tribe/Consortium...

  12. 38 CFR 15.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Program accessibility: New construction and alterations. 15.151 Section 15.151 Pensions, Bonuses, and Veterans' Relief... and alterations. Each building or part of a building that is constructed or altered by, on behalf...

  13. 38 CFR 15.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Program accessibility: New construction and alterations. 15.151 Section 15.151 Pensions, Bonuses, and Veterans' Relief... and alterations. Each building or part of a building that is constructed or altered by, on behalf...

  14. Construction safety program for the National Ignition Facility, Appendix A

    SciTech Connect

    Cerruti, S.J.

    1997-06-26

    Topics covered in this appendix include: General Rules-Code of Safe Practices; 2. Personal Protective Equipment; Hazardous Material Control; Traffic Control; Fire Prevention; Sanitation and First Aid; Confined Space Safety Requirements; Ladders and Stairways; Scaffolding and Lift Safety; Machinery, Vehicles, and Heavy Equipment; Welding and Cutting-General; Arc Welding; Oxygen/Acetylene Welding and Cutting; Excavation, Trenching, and Shoring; Fall Protection; Steel Erection; Working With Asbestos; Radiation Safety; Hand Tools; Electrical Safety; Nonelectrical Work Performed Near Exposed High-Voltage Power-Distribution Equipment; Lockout/Tagout Requirements; Rigging; A-Cranes; Housekeeping; Material Handling and Storage; Lead; Concrete and Masonry Construction.

  15. Construction: Carpentry Concentration. Program CIP: 46.0000 Construction: Carpentry Concentration

    ERIC Educational Resources Information Center

    Agee, Kelly, Ed.

    2008-01-01

    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  16. 7 CFR 15e.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Program accessibility: New construction and alterations. 15e.151 Section 15e.151 Agriculture Office of the Secretary of Agriculture ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT...

  17. 7 CFR 15e.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Program accessibility: New construction and alterations. 15e.151 Section 15e.151 Agriculture Office of the Secretary of Agriculture ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT...

  18. Constructing a Self-Funded Program Takes More than Just Dollars and Cents

    ERIC Educational Resources Information Center

    Burke, Scott

    2012-01-01

    With a little ingenuity and a lot of dedication, the author created a self-funded construction program that is weathering the ups and downs of school funding; it enjoys great support from the community, is accomplishing more with less, and collaborative efforts between teachers are paying off. Creating such a program takes time, vision,…

  19. 75 FR 60263 - Federal Acquisition Regulation; Offering a Construction Requirement-8(a) Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-29

    ... Federal Acquisition Regulation; Offering a Construction Requirement--8(a) Program AGENCIES: Department of... Regulations Council (Councils) are issuing a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR subpart 19.8, Contracting with the Small Business Administration (The 8(a) Program),...

  20. 50 CFR 550.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Program accessibility: New construction and alterations. 550.151 Section 550.151 Wildlife and Fisheries MARINE MAMMAL COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY MARINE...

  1. 50 CFR 550.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Program accessibility: New construction and alterations. 550.151 Section 550.151 Wildlife and Fisheries MARINE MAMMAL COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY MARINE...

  2. 50 CFR 550.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Program accessibility: New construction and alterations. 550.151 Section 550.151 Wildlife and Fisheries MARINE MAMMAL COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY MARINE...

  3. 50 CFR 550.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Program accessibility: New construction and alterations. 550.151 Section 550.151 Wildlife and Fisheries MARINE MAMMAL COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY MARINE...

  4. 19 CFR 201.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Program accessibility: New construction and alterations. 201.151 Section 201.151 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Enforcement of Nondiscrimination on the Basis of Handicap in Programs...

  5. 19 CFR 201.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Program accessibility: New construction and alterations. 201.151 Section 201.151 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Enforcement of Nondiscrimination on the Basis of Handicap in Programs...

  6. 17 CFR 200.651 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Program accessibility: New construction and alterations. 200.651 Section 200.651 Commodity and Securities Exchanges SECURITIES AND... Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the Securities and...

  7. 17 CFR 200.651 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Program accessibility: New construction and alterations. 200.651 Section 200.651 Commodity and Securities Exchanges SECURITIES AND... Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the Securities and...

  8. 17 CFR 200.651 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Program accessibility: New construction and alterations. 200.651 Section 200.651 Commodity and Securities Exchanges SECURITIES AND... Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the Securities and...

  9. 22 CFR 1600.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE...

  10. 22 CFR 1600.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE...

  11. 22 CFR 1600.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE...

  12. 22 CFR 1600.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE...

  13. 22 CFR 1600.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Program accessibility: New construction and alterations. 1600.151 Section 1600.151 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE...

  14. Programs for the Construction and Analysis of Custom Questionnaires and Rating Scales

    ERIC Educational Resources Information Center

    Doyle, Kenneth O., Jr.; Wattawa, Scott

    1977-01-01

    Programs are described for the construction and analysis of student evaluation questionnaires and rating scales that are custom-designed for individual course instructors. Minor modifications would permit the use of these programs for other kinds of questionnaires and rating scales as well as for achievement tests. (Author)

  15. 22 CFR 530.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: New construction and alterations. 530.151 Section 530.151 Foreign Relations BROADCASTING BOARD OF GOVERNORS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE BROADCASTING BOARD...

  16. Highway Safety Program Manual: Volume 12: Highway Design, Construction and Maintenance.

    ERIC Educational Resources Information Center

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    Volume 12 of the 19-volume Highway Safety Program Manual (which provides guidance to State and local governments on preferred highway safety practices) focuses on highway design, construction and maintenance. The purpose and specific objectives of such a program are described. Federal authority in the area of highway safety and policies regarding…

  17. 45 CFR 1214.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Program accessibility: New construction and alterations. 1214.151 Section 1214.151 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY...

  18. 50 CFR 550.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Program accessibility: New construction and alterations. 550.151 Section 550.151 Wildlife and Fisheries MARINE MAMMAL COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY MARINE...

  19. Creswell's Energy Efficient Construction Program: A Big Project for a Small School.

    ERIC Educational Resources Information Center

    Kelsh, Bruce

    1982-01-01

    In Creswell (Oregon) High School's award winning vocational education program, students study energy efficient construction along with basic building skills. Part of the program has been the active recruitment of female, minority, disadvantaged, and handicapped students into the vocational area. Students have assembled solar hot water collectors,…

  20. 22 CFR 1005.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: New construction and alterations. 1005.151 Section 1005.151 Foreign Relations INTER-AMERICAN FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE INTER-AMERICAN...

  1. 22 CFR 1510.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Program accessibility: New construction and alterations. 1510.151 Section 1510.151 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE AFRICAN DEVELOPMENT...

  2. 45 CFR 2301.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) ARCTIC RESEARCH COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES ARCTIC RESEARCH COMMISSION § 2301.151 Program accessibility: New... of, or for the use of the agency shall be designed, constructed, or altered so as to be...

  3. 43 CFR 17.551 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Program accessibility: New construction and alterations. 17.551 Section 17.551 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OF THE DEPARTMENT OF THE INTERIOR Enforcement of...

  4. Item Pool Construction Using Mixed Integer Quadratic Programming (MIQP). GMAC® Research Report RR-14-01

    ERIC Educational Resources Information Center

    Han, Kyung T.; Rudner, Lawrence M.

    2014-01-01

    This study uses mixed integer quadratic programming (MIQP) to construct multiple highly equivalent item pools simultaneously, and compares the results from mixed integer programming (MIP). Three different MIP/MIQP models were implemented and evaluated using real CAT item pool data with 23 different content areas and a goal of equal information…

  5. 25 CFR 170.404 - What happens when a tribe uses its IRR Program construction funds for transportation planning?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What happens when a tribe uses its IRR Program... tribe uses its IRR Program construction funds for transportation planning? In order for IRR Program... percent of its IRR Program construction funds, whichever is greater, for transportation planning. If...

  6. 25 CFR 170.404 - What happens when a tribe uses its IRR Program construction funds for transportation planning?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What happens when a tribe uses its IRR Program... tribe uses its IRR Program construction funds for transportation planning? In order for IRR Program... percent of its IRR Program construction funds, whichever is greater, for transportation planning. If...

  7. COOPERATIVE RESEARCH IN C1 CHEMISTRY

    SciTech Connect

    Gerald P. Huffman

    2001-04-30

    Faculty and students from five universities (Kentucky, West Virginia, Utah, Pittsburgh and Auburn) are collaborating on a basic research program to develop novel C1 chemistry processes for the production of clean, high quality transportation fuel. An Industrial Advisory Board (IAB) with members from Chevron, Eastman Chemical, Energy International, Teir Associates, and the Department of Defense has been formed to provide practical guidance to the program. The program has two principal objectives. (1) Develop technology for conversion of C1 source materials (natural gas, synthesis gas, carbon dioxide and monoxide, and methanol) into clean, high efficiency transportation fuel. (2) Develop novel processes for producing hydrogen from natural gas and other hydrocarbons. Some of the principal accomplishments of the program in its first two years are: (1) The addition of acetylenic compounds in Fischer-Tropsch synthesis is found to produce significant amounts of oxygenated products in FT diesel fuels. Such oxygenated products should decrease particulate matter (PM) emissions. (2) Nanoscale, binary, Fe-based catalysts supported on alumina have been shown to have significant activity for the decomposition of methane into pure hydrogen and potentially valuable multi-walled carbon nanotubes. (3) Catalytic synthesis processes have been developed for synthesis of diethyl carbonate, higher ethers, and higher alcohols from C1 source materials. Testing of the effect of adding these oxygenates to diesel fuel on PM emissions has begun using a well-equipped small diesel engine test facility. (4) Supercritical fluid (SCF) FT synthesis has been conducted under SCF hexane using both Fe and Co catalysts. There is a marked effect on the hydrocarbon product distribution, with a shift to higher carbon number products. These and other results are summarized.

  8. Accurate construction of consensus genetic maps via integer linear programming.

    PubMed

    Wu, Yonghui; Close, Timothy J; Lonardi, Stefano

    2011-01-01

    We study the problem of merging genetic maps, when the individual genetic maps are given as directed acyclic graphs. The computational problem is to build a consensus map, which is a directed graph that includes and is consistent with all (or, the vast majority of) the markers in the input maps. However, when markers in the individual maps have ordering conflicts, the resulting consensus map will contain cycles. Here, we formulate the problem of resolving cycles in the context of a parsimonious paradigm that takes into account two types of errors that may be present in the input maps, namely, local reshuffles and global displacements. The resulting combinatorial optimization problem is, in turn, expressed as an integer linear program. A fast approximation algorithm is proposed, and an additional speedup heuristic is developed. Our algorithms were implemented in a software tool named MERGEMAP which is freely available for academic use. An extensive set of experiments shows that MERGEMAP consistently outperforms JOINMAP, which is the most popular tool currently available for this task, both in terms of accuracy and running time. MERGEMAP is available for download at http://www.cs.ucr.edu/~yonghui/mgmap.html.

  9. 25 CFR 1000.240 - What construction programs included in an AFA are subject to this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What construction programs included in an AFA are subject... in an AFA are subject to this subpart? (a) All BIA and non-BIA construction programs included in an AFA are subject to this subpart. This includes design, construction, repair, improvement,...

  10. 25 CFR 1000.240 - What construction programs included in an AFA are subject to this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What construction programs included in an AFA are subject... in an AFA are subject to this subpart? (a) All BIA and non-BIA construction programs included in an AFA are subject to this subpart. This includes design, construction, repair, improvement,...

  11. 25 CFR 1000.240 - What construction programs included in an AFA are subject to this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What construction programs included in an AFA are subject... in an AFA are subject to this subpart? (a) All BIA and non-BIA construction programs included in an AFA are subject to this subpart. This includes design, construction, repair, improvement,...

  12. 25 CFR 1000.240 - What construction programs included in an AFA are subject to this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What construction programs included in an AFA are subject... in an AFA are subject to this subpart? (a) All BIA and non-BIA construction programs included in an AFA are subject to this subpart. This includes design, construction, repair, improvement,...

  13. 25 CFR 1000.240 - What construction programs included in an AFA are subject to this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What construction programs included in an AFA are subject... in an AFA are subject to this subpart? (a) All BIA and non-BIA construction programs included in an AFA are subject to this subpart. This includes design, construction, repair, improvement,...

  14. Cooperative Research in C1 Chemistry

    SciTech Connect

    Gerald P. Huffman

    2000-10-27

    C1 chemistry refers to the conversion of simple carbon-containing materials that contain one carbon atom per molecule into valuable products. The feedstocks for C1 chemistry include natural gas, carbon dioxide, carbon monoxide, methanol and synthesis gas (a mixture of carbon monoxide and hydrogen). Synthesis gas, or syngas, is produced primarily by the reaction of natural gas, which is principally methane, with steam. It can also be produced by gasification of coal, petroleum coke, or biomass. The availability of syngas from coal gasification is expected to increase significantly in the future because of increasing development of integrated gasification combined cycle (IGCC) power generation. Because of the abundance of remote natural gas, the advent of IGCC, and environmental advantages, C1 chemistry is expected to become a major area of interest for the transportation fuel and chemical industries in the relatively near future. The CFFLS will therefore perform a valuable national service by providing science and engineering graduates that are trained in this important area. Syngas is the source of most hydrogen. Approximately 10 trillion standard cubic feet (SCF) of hydrogen are manufactured annually in the world. Most of this hydrogen is currently used for the production of ammonia and in a variety of refining and chemical operations. However, utilization of hydrogen in fuel cells is expected to grow significantly in the next century. Syngas is also the feedstock for all methanol and Fischer-Tropsch plants. Currently, world consumption of methanol is over 25 million tons per year. There are many methanol plants in the U.S. and throughout the world. Methanol and oxygenated transportation fuel products play a significant role in the CFFLS C1 program. Currently, the only commercial Fischer-Tropsch plants are overseas, principally in South Africa (SASOL). However, new plants are being built or planned for a number of locations. One possible location for future F

  15. Software for C1 interpolation

    NASA Technical Reports Server (NTRS)

    Lawson, C. L.

    1977-01-01

    The problem of mathematically defining a smooth surface, passing through a finite set of given points is studied. Literature relating to the problem is briefly reviewed. An algorithm is described that first constructs a triangular grid in the (x,y) domain, and first partial derivatives at the modal points are estimated. Interpolation in the triangular cells using a method that gives C sup.1 continuity overall is examined. Performance of software implementing the algorithm is discussed. Theoretical results are presented that provide valuable guidance in the development of algorithms for constructing triangular grids.

  16. A Scientist or Salesman? Identity Construction through Referent Honorifics on a Japanese Shopping Channel Program

    ERIC Educational Resources Information Center

    Cook, Haruko Minegishi

    2013-01-01

    This paper explores how referent honorifics contribute to identity construction on a Japanese TV shopping channel program. Drawing on Ochs' twostep model of indexicality (1993, 1996) and Agah's proposal (1993) that honorifics are not directly linked to social status but index a "relative position within events of discursive interaction"…

  17. The Sexual Assault Teach In Program: Building Constructive Campus-Wide Discussions to Inspire Change

    ERIC Educational Resources Information Center

    Katz, Jennifer; DuBois, Melinda

    2013-01-01

    To begin to address the problem of campus sexual assault, we conducted a Teach In, an educational forum used to explore complex social problems. All students, faculty, and staff at our small liberal arts college were invited to participate. This paper summarizes our Teach In program, goals, and methods. By engaging in constructive, informed…

  18. The Laborers-AGC Construction Skills Training Program. Final Performance Report.

    ERIC Educational Resources Information Center

    Tippie, John L.; Rice, Eric

    Patterned after a previously successful Laborers-Associated General Contractors model named the Construction Skills Training Program, a demonstration project was implemented at five regional training centers. At least eight courses were created, combined, or revised. Four full-length audiovisual support pieces were completed. Three courses were…

  19. 44 CFR 16.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Program accessibility: New construction and alterations. 16.151 Section 16.151 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS...

  20. 44 CFR 16.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Program accessibility: New construction and alterations. 16.151 Section 16.151 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS...

  1. 41 CFR 105-8.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Program accessibility: New construction and alterations. 105-8.151 Section 105-8.151 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION...

  2. An Interactive Computer Program to Construct Adaptive Landscapes and to Simulate the Changes Expected with Selection

    ERIC Educational Resources Information Center

    Hull, Peter

    1978-01-01

    Describes an interactive computer program which can be used by students to construct adaptive landscapes of two types as an illustration of the expected effects of selection. Simulates effects of selection on populations of this type and changes of gene frequency can be plotted on the same contour map. (Author/MA)

  3. 48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Defense Environmental... System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction...

  4. 48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Defense Environmental... System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction...

  5. 48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Defense Environmental... System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction...

  6. 48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Defense Environmental... System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction...

  7. 48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Defense Environmental... System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction...

  8. 32 CFR 1807.151 - Program accessibility: new construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Program accessibility: new construction and alterations. 1807.151 Section 1807.151 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN...

  9. 32 CFR 1807.151 - Program accessibility: new construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Program accessibility: new construction and alterations. 1807.151 Section 1807.151 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN...

  10. 32 CFR 1807.151 - Program accessibility: new construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Program accessibility: new construction and alterations. 1807.151 Section 1807.151 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN...

  11. 32 CFR 1807.151 - Program accessibility: new construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Program accessibility: new construction and alterations. 1807.151 Section 1807.151 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN...

  12. 32 CFR 1807.151 - Program accessibility: new construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Program accessibility: new construction and alterations. 1807.151 Section 1807.151 National Defense Other Regulations Relating to National Defense NATIONAL COUNTERINTELLIGENCE CENTER ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN...

  13. 34 CFR 1200.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Program accessibility: New construction and alterations. 1200.151 Section 1200.151 Education Regulations of the Offices of the Department of Education (Continued) NATIONAL COUNCIL ON DISABILITY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP...

  14. 17 CFR 149.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Program accessibility: New construction and alterations. 149.151 Section 149.151 Commodity and Securities Exchanges COMMODITY FUTURES... usable by handicapped persons. The definitions, requirements, and standards of the Architectural...

  15. 17 CFR 149.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Program accessibility: New construction and alterations. 149.151 Section 149.151 Commodity and Securities Exchanges COMMODITY FUTURES... usable by handicapped persons. The definitions, requirements, and standards of the Architectural...

  16. How Learners Perceive They Construct Knowledge as Participants in Outreach Programs

    ERIC Educational Resources Information Center

    Yelich Biniecki, Susan

    2010-01-01

    The purpose of this interpretive qualitative research study was to explore how adult learners perceive they construct knowledge in connection to their participation in educational outreach programs, encompassing a continuum of formal, non-formal, and informal learning experiences. The study context involved three world affairs outreach education…

  17. Constructing Adult Literacies at a Local Literacy Tutor-Training Program

    ERIC Educational Resources Information Center

    Roderick, Ryan

    2013-01-01

    This study investigates how literacy was constructed at an adult literacy organization's volunteer tutor-training program. By drawing on qualitative analysis of training texts used during training, such as training evaluations, and data gathered from interviews with experienced tutors, it is possible to identify the assumptions about literacy…

  18. Environmental Assessment for the Construction and Operation of the Constellation Program A-3 Test Stand

    NASA Technical Reports Server (NTRS)

    Kennedy, Carolyn D.

    2007-01-01

    This document is an environmental assessment that examines the environmental impacts of a proposed plan to clear land and to construct a test stand for use in testing the J-2X rocket engine at simulated altitude conditions in support of NASA's Constellation Program.

  19. Programming for the Internet and Experiential Learning: A New Approach Incorporating a Constructed World

    ERIC Educational Resources Information Center

    Taylor, Adam P. R.

    2007-01-01

    This paper reports on a novel approach taken by the author to the teaching of an Internet programming course targeted at final year diploma and second year degree students. The uniqueness of engineers and their identity is discussed, as is the self-constructed world and ways of knowing in which humankind operates. The novel approach to teaching a…

  20. 36 CFR 1154.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... construction and alterations. 1154.151 Section 1154.151 Parks, Forests, and Public Property ARCHITECTURAL AND... ACTIVITIES CONDUCTED BY THE ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD § 1154.151 Program... standards of the Architectural Barriers Act (42 U.S.C. 4151-4157), as established in 41 CFR 101-19.600...

  1. Engineering Certification Program Self-Study Course, Construction Inspection - Part II. Engineering Management [Series].

    ERIC Educational Resources Information Center

    Owsley, Fran, Ed.

    This book is a part of a self-study sequence in an engineering certification program. This volume concerns inspection and quality control of concrete structures. Sections titles are Inspection and Quality Control of Concrete; General Guides for Concrete Work; Concrete Floor and Slab Construction; Concrete Formwork; Correct and Incorrect Methods of…

  2. Breaking Ground: Rebuilding New Jersey's Urban Schools. The Abbott School Construction Program

    ERIC Educational Resources Information Center

    Ponessa, Joan

    2004-01-01

    This report presents a brief history of the Abbott School Construction Program, describes the implementation to date, lays out some current challenges, and outlines lessons learned from the process so far--what is known now about how such an initiative should be planned and carried out. The report is intended to illuminate the complex process of…

  3. THE CONSTRUCTION AND EVALUATION OF A SELF-INSTRUCTIONAL PROGRAM IN RUSSIAN.

    ERIC Educational Resources Information Center

    SALTZMAN, IRVING J.

    A SELF-INSTRUCTIONAL PROGRAMED COURSE IN RUSSIAN WAS CONSTRUCTED. FIFTEEN THOUSAND PRINTED FRAMES AND 306 TAPES WERE PREPARED FOR USE BY HIGH SCHOOL OR FIRST-SEMESTER COLLEGE STUDENTS. THE MATERIALS WERE USED TO (1) PROVIDE A RESEARCH TOOL FOR STUDYING SECOND LANGUAGE INSTRUCTION AND ACQUISITION AND (2) YIELD INFORMATIO ABOUT THE DEVELOPMENT OF…

  4. THE ENZYMATIC NATURE OF C'1r

    PubMed Central

    Naff, George B.; Ratnoff, Oscar D.

    1968-01-01

    Human C'1, a macromolecular complex composed of three subunits, is the zymogen for at least two distinct enzymes. Preparations of one subunit, C'1r, functioned as a protease which converted another subunit, C'1s, to C'1 esterase. The conversion of C'1s to C'1 esterase by C'1r was blocked by Liquoid, phenyl methylsulfonyl fluoride, and calcium ions, but not by soybean trypsin inhibitor, hirudin, or heparin. Preparations of C'1r also possessed two additional functions, i.e., the ability to hydrolyze certain synthetic amino acid esters and to participate in immune hemolysis. Evidence was presented which indicates that these three functions are properties of a single entity, C'1r, but not of the same portion of its molecular structure. These observations suggest that C'1r has at least two active sites, one for its reaction with C'1q, an additional subunit of C'1, and one for its reaction with C'1s; together, the three subcomponents, C'1q, C'1r, and C'1s, form a single functional unit, the first component of complement. PMID:5675434

  5. MAPAG: a computer program to construct 2- and 3-dimensional antigenic maps.

    PubMed

    Aguilar, R C; Retegui, L A; Roguin, L P

    1994-01-01

    The contact area between an antibody (Ab) and the antigen (Ag) is called antigenic determinant or epitope. The first step in the characterization of an Ag by using monoclonal antibodies (MAb) is to map the relative distribution of the corresponding epitopes on the Ag surface. The computer program MAPAG has been devised to automatically construct antigenic maps. MAPAG is fed with a binary matrix of experimental data indicating the ability of paired MAb to bind or not simultaneously to the Ag. The program is interactive menu-driven and allows the user an easy data handling. MAPAG utilizes iterative processes to construct and to adjust the final map, which is graphically shown as a 2- or a 3-dimensional model. Additionally, the antigenic map obtained can be optionally modified by the user or readjusted by the program. The suitability of MAPAG was illustrated by running experimental data from literature and comparing antigenic maps constructed by the program with those elaborated by the investigators without the assistance of a computer. Furthermore, since some MAb could present negative allosteric effects leading to misinterpretation of data, MAPAG has been provided with an approximate reasoning module to solve such anomalous situations. Results indicated that the program can be successfully employed as a simple, fast and reliable antigenic model-builder.

  6. Residential building code compliance: Implications for evaluating the performance of utility residential new construction programs

    SciTech Connect

    Vine, E.

    1996-05-01

    Knowing how well builders comply with (or exceed) energy-related building codes is critical for completing a sound evaluation of utility residential new construction programs and for determining the actual cost-effectiveness of these programs. Obtaining credit from utility regulators for additional energy savings from code compliance in participant houses as a result of the utility program is one of the key options available for utilities for improving the cost-effectiveness of these programs. In this paper, the authors examine residential building energy code compliance and specific code violations in three states (California, Oregon and Washington). They then compare residential building energy code compliance for program participants and nonparticipants as well as estimates of the energy savings impacts from noncompliance. The authors also point out some of the methodological limitations of these studies which limit the ability to generalize from these studies.

  7. Military construction program economic analysis manual: Text and appendixes: Hazardous Waste Remedial Actions Program. [Contains glossary

    SciTech Connect

    Not Available

    1987-12-01

    This manual enables the US Air Force to comprehensively and systematically analyze alternative approaches to meeting its military construction requirements. The manual includes step-by-step procedures for completing economic analyses for military construction projects, beginning with determining if an analysis is necessary. Instructions and a checklist of the tasks involved for each step are provided; and examples of calculations and illustrations of completed forms are included. The manual explains the major tasks of an economic analysis, including identifying the problem, selecting realistic alternatives for solving it, formulating appropriate assumptions, determining the costs and benefits of the alternatives, comparing the alternatives, testing the sensitivity of major uncertainties, and ranking the alternatives. Appendixes are included that contain data, indexes, and worksheets to aid in performing the economic analyses. For reference, Volume 2 contains sample economic analyses that illustrate how each form is filled out and that include a complete example of the documentation required. 6 figs., 12 tabs.

  8. Construction

    DTIC Science & Technology

    2002-01-01

    Harbor Deepening Project, Jacksonville, FL Palm Valley Bridge Project, Jacksonville, FL Rotary Club of San Juan, San Juan, PR Tren Urbano Subway...David. What is nanotechnology? What are its implications for construction?, Foresight/CRISP Workshop on Nanotechnology, Royal Society of Arts

  9. Construction

    DTIC Science & Technology

    2002-01-01

    San Juan, PR Tren Urbano Subway Project, San Juan, PR U.S. Army South, San Juan, PR U.S. Coast Guard Housing Project, San Juan, PR U.S. Coast Guard...construction?, Foresight/CRISP Workshop on Nanotechnology, Royal Society of Arts . Cheltenham, England: 2001, p.5. 56 Concrete Proposals, Economist, July 24

  10. Cone Quasi-Concave Multi-Objective Programming Theory and Dominance Cone Constructions.

    DTIC Science & Technology

    1988-08-01

    4 Cone Quasi-Concave Multi-Objective Prog ramm in(I Theory and Dominance Cone Constructions by A. Chames Z. M. Huang J. J. Rousseau 0. B. Sun 0. L...Report 606 Cone Quasi-Concave Multi-Objective Programming: Theory and Dominance Cone Constructions by A. Chames Z. M. Huang J. J. Rousseau D. B. Sun...permitted for any purpose of the U.S. Govemement. Tr% C CENTER FOR CYBERNETIC STUDIES cV- A. Chames , Director V 3 D 1 College of Business Administration

  11. 25 CFR 1000.248 - What is the Tribe's/Consortium's role in a construction program included in an AFA?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... program included in an AFA? 1000.248 Section 1000.248 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN.../Consortium's role in a construction program included in an AFA? The Tribe/Consortium has the following role regarding a construction portion of an AFA: (a) Under the Act, the Indian Tribe/Consortium must...

  12. 25 CFR 1000.249 - What is the Secretary's role in a construction program in an AFA?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... an AFA? 1000.249 Section 1000.249 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program in an AFA? The Secretary has the following role regarding a construction program contained in an AFA: (a) Except as provided in § 1000.256, the Secretary may review and approve planning...

  13. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What special provisions must be included in an AFA that... must be included in an AFA that contains a construction program? An AFA that contains a construction program must address the requirements listed in this section. (a) The AFA must specify how the...

  14. 25 CFR 1000.248 - What is the Tribe's/Consortium's role in a construction program included in an AFA?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... program included in an AFA? 1000.248 Section 1000.248 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN.../Consortium's role in a construction program included in an AFA? The Tribe/Consortium has the following role regarding a construction portion of an AFA: (a) Under the Act, the Indian Tribe/Consortium must...

  15. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What special provisions must be included in an AFA that... must be included in an AFA that contains a construction program? An AFA that contains a construction program must address the requirements listed in this section. (a) The AFA must specify how the...

  16. 25 CFR 1000.249 - What is the Secretary's role in a construction program in an AFA?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... an AFA? 1000.249 Section 1000.249 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program in an AFA? The Secretary has the following role regarding a construction program contained in an AFA: (a) Except as provided in § 1000.256, the Secretary may review and approve planning...

  17. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What special provisions must be included in an AFA that... must be included in an AFA that contains a construction program? An AFA that contains a construction program must address the requirements listed in this section. (a) The AFA must specify how the...

  18. 25 CFR 1000.249 - What is the Secretary's role in a construction program in an AFA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... an AFA? 1000.249 Section 1000.249 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program in an AFA? The Secretary has the following role regarding a construction program contained in an AFA: (a) Except as provided in § 1000.256, the Secretary may review and approve planning...

  19. 25 CFR 1000.248 - What is the Tribe's/Consortium's role in a construction program included in an AFA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... program included in an AFA? 1000.248 Section 1000.248 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN.../Consortium's role in a construction program included in an AFA? The Tribe/Consortium has the following role regarding a construction portion of an AFA: (a) Under the Act, the Indian Tribe/Consortium must...

  20. 25 CFR 1000.248 - What is the Tribe's/Consortium's role in a construction program included in an AFA?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... program included in an AFA? 1000.248 Section 1000.248 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN.../Consortium's role in a construction program included in an AFA? The Tribe/Consortium has the following role regarding a construction portion of an AFA: (a) Under the Act, the Indian Tribe/Consortium must...

  1. 25 CFR 1000.248 - What is the Tribe's/Consortium's role in a construction program included in an AFA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... program included in an AFA? 1000.248 Section 1000.248 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN.../Consortium's role in a construction program included in an AFA? The Tribe/Consortium has the following role regarding a construction portion of an AFA: (a) Under the Act, the Indian Tribe/Consortium must...

  2. 25 CFR 1000.249 - What is the Secretary's role in a construction program in an AFA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... an AFA? 1000.249 Section 1000.249 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program in an AFA? The Secretary has the following role regarding a construction program contained in an AFA: (a) Except as provided in § 1000.256, the Secretary may review and approve planning...

  3. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What special provisions must be included in an AFA that... must be included in an AFA that contains a construction program? An AFA that contains a construction program must address the requirements listed in this section. (a) The AFA must specify how the...

  4. 25 CFR 1000.243 - What special provisions must be included in an AFA that contains a construction program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What special provisions must be included in an AFA that... must be included in an AFA that contains a construction program? An AFA that contains a construction program must address the requirements listed in this section. (a) The AFA must specify how the...

  5. 25 CFR 1000.249 - What is the Secretary's role in a construction program in an AFA?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... an AFA? 1000.249 Section 1000.249 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program in an AFA? The Secretary has the following role regarding a construction program contained in an AFA: (a) Except as provided in § 1000.256, the Secretary may review and approve planning...

  6. Concept document of the repository-based software engineering program: A constructive appraisal

    NASA Technical Reports Server (NTRS)

    1992-01-01

    A constructive appraisal of the Concept Document of the Repository-Based Software Engineering Program is provided. The Concept Document is designed to provide an overview of the Repository-Based Software Engineering (RBSE) Program. The Document should be brief and provide the context for reading subsequent requirements and product specifications. That is, all requirements to be developed should be traceable to the Concept Document. Applied Expertise's analysis of the Document was directed toward assuring that: (1) the Executive Summary provides a clear, concise, and comprehensive overview of the Concept (rewrite as necessary); (2) the sections of the Document make best use of the NASA 'Data Item Description' for concept documents; (3) the information contained in the Document provides a foundation for subsequent requirements; and (4) the document adequately: identifies the problem being addressed; articulates RBSE's specific role; specifies the unique aspects of the program; and identifies the nature and extent of the program's users.

  7. Construction

    DTIC Science & Technology

    2001-01-01

    equipment. Engineering , building, and project owner/ developers include industrial manufacturers, public works departments, public and private...Honolulu, Hawaii: U.S. Pacific Command, Headquarters Building Naval Facilities Engineer Command - Ford Island Development Program, Hawaii 2... industry where reputation means everything and industry -leading firms invest significant resources in business development and work hard to ensure

  8. Determining Recoupable Funds Using the Military Construction, Army Mobilization Program (MOBPRO).

    DTIC Science & Technology

    1992-07-01

    Construction, Army (MCA) programming is a complex, dynamic process operating in an environment that involves many functional managers. At all levels of the MCA...preferred methods for determining Government liability in convenience terminations, which involve interpreting fixed-price contracts as hybrid cost...the contract, initiate all actions necessary to close out the contract, and submit a settlement proposal. The settlement proposal informs the

  9. Curtiss XSO3C-1 Seagull

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Curtiss XSO3C-1 Seagull: Although drag reduction was very important to radial engined aircraft, it was no less important to aircraft such as this inline Ranger powered Curtiss XSO3C-1 Seagull. Here the Seagull is shown in the 30 x 60 Full Scale Tunnel in October of 1940. The XSO3C-1 was also undergoing study to improve engine cooling. Published in Aircraft; FST; Curtiss XSO3C-1 Seagull; Full Scale Tunnel; Nicklas

  10. 29 CFR 2575.502c-1 - Adjusted civil penalty under section 502(c)(1).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Adjusted civil penalty under section 502(c)(1). 2575.502c-1 Section 2575.502c-1 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY... ERISA Title I § 2575.502c-1 Adjusted civil penalty under section 502(c)(1). In accordance with...

  11. Correlation between safety climate and contractor safety assessment programs in construction

    PubMed Central

    Sparer, EH1; Murphy, LA; Taylor, KM; Dennerlein, Jt

    2015-01-01

    Background Contractor safety assessment programs (CSAPs) measure safety performance by integrating multiple data sources together; however, the relationship between these measures of safety performance and safety climate within the construction industry is unknown. Methods 401 construction workers employed by 68 companies on 26 sites and 11 safety managers employed by 11 companies completed brief surveys containing a nine-item safety climate scale developed for the construction industry. CSAP scores from ConstructSecure, Inc., an online CSAP database, classified these 68 companies as high or low scorers, with the median score of the sample population as the threshold. Spearman rank correlations evaluated the association between the CSAP score and the safety climate score at the individual level, as well as with various grouping methodologies. In addition, Spearman correlations evaluated the comparison between manager-assessed safety climate and worker-assessed safety climate. Results There were no statistically significant differences between safety climate scores reported by workers in the high and low CSAP groups. There were, at best, weak correlations between workers’ safety climate scores and the company CSAP scores, with marginal statistical significance with two groupings of the data. There were also no significant differences between the manager-assessed safety climate and the worker-assessed safety climate scores. Conclusions A CSAP safety performance score does not appear to capture safety climate, as measured in this study. The nature of safety climate in construction is complex, which may be reflective of the challenges in measuring safety climate within this industry. PMID:24038403

  12. Refinable C(1) spline elements for irregular quad layout.

    PubMed

    Nguyen, Thien; Peters, Jörg

    2016-03-01

    Building on a result of U. Reif on removable singularities, we construct C(1) bi-3 splines that may include irregular points where less or more than four tensor-product patches meet. The resulting space complements PHT splines, is refinable and the refined spaces are nested, preserving for example surfaces constructed from the splines. As in the regular case, each quadrilateral has four degrees of freedom, each associated with one spline and the splines are linearly independent. Examples of use for surface construction and isogeometric analysis are provided.

  13. Construction safety program for the National Ignition Facility, July 30, 1999

    SciTech Connect

    Benjamin, D W

    1999-07-30

    The Construction Safety Program (CSP) for NIF sets forth the responsibilities, guidelines, rules, policies and regulations for all workers involved in the construction, special equipment installation, acceptance testing, and start-up of NIF at LLNL during the construction period of NIF. During this period, all workers are required to implement measures to create a universal awareness which promotes safe practice at the work site, and which will achieve NIF's management objectives in preventing accidents and illnesses. Construction safety for NIF is predicated on everyone performing their jobs in a manner that prevents job-related disabling injuries and illnesses. Integrated Safety Management (ISM) is practiced in the execution of all activities associated with the NIF Project. The seven Principles of ISM are: (1) Line management is responsible for safety. (2) Clear roles and responsibilities are established and maintained. (3) Personnel possess competence commensurate with responsibilities. (4) Resource allocations are balanced, making ES and H a priority in project planning and execution. (5) Safety requirements are identified and implemented. (6) Hazard controls are tailored to the project work. (7) Operations are authorized before work begins.

  14. C1 inhibitor: quantification and purification.

    PubMed

    Varga, Lilian; Dobó, József

    2014-01-01

    C1 inhibitor is a multipotent serpin capable of inhibiting the classical and the lectin pathways of complement, the fibrinolytic system, and contact/kinin system of coagulation. Deficiency of C1 inhibitor manifest as hereditary angioedema (HAE), an autosomal dominant hereditary disease. Measuring the C1 inhibitor level is of vital importance for the diagnosis of HAE and also for monitoring patients receiving C1 inhibitor for therapy. Determination of the antigenic C1 inhibitor level by the radial immunodiffusion (RID) technique is described in detail in this chapter. The presented purification method of plasma C1 inhibitor is primarily based on its high carbohydrate content and its affinity to the lectin jacalin.

  15. Northwest Energy Efficient Manufactured Housing Program: High Performance Manufactured Home Prototyping and Construction Development

    SciTech Connect

    Hewes, T.; Peeks, B.

    2013-11-01

    The Building America Partnership for Improved Residential Construction, the Bonneville Power Administration (BPA), and Northwest Energy Works (NEW), the current Northwest Energy Efficient Manufactured Housing Program (NEEM) administrator, have been collaborating to conduct research on new specifications that would improve on the energy requirements of a NEEM home. In its role as administrator, NEW administers the technical specs, performs research and engineering analysis, implements ongoing construction quality management procedures, and maintains a central database with home tracking. This project prototyped and assessed the performances of cost-effective high performance building assemblies and mechanical systems that are not commonly deployed in the manufacturing setting. The package of measures is able to reduce energy used for space conditioning, water heating and lighting by 50 percent over typical manufactured homes produced in the northwest.

  16. Northwest Energy Efficient Manufactured Housing Program: High Performance Manufactured Home Prototyping and Construction Development

    SciTech Connect

    Hewes, Tom; Peeks, Brady

    2013-11-01

    The Building America Partnership for Improved Residential Construction, the Bonneville Power Administration (BPA), and Northwest Energy Works (NEW), the current Northwest Energy Efficient Manufactured Housing Program (NEEM) administrator, have been collaborating to conduct research on new specifications that would improve on the energy requirements of a NEEM home. In its role as administrator, NEW administers the technical specs, performs research and engineering analysis, implements ongoing construction quality management procedures, and maintains a central database with home tracking. This project prototyped and assessed the performances of cost-effective high performance building assemblies and mechanical systems that are not commonly deployed in the manufacturing setting. The package of measures is able to reduce energy used for space conditioning, water heating and lighting by 50% over typical manufactured homes produced in the northwest.

  17. Relating Women's Experience and Skills to Competencies Required in Selected Occupations and Vocational Education Programs. Project Report, Task C1, Revised Competency Analysis: Credentialing Women's Life Experiences (Project ACCESS).

    ERIC Educational Resources Information Center

    Ekstrom, Ruth B.; And Others

    Competency scales were developed for 10 direct-entry occupations and 10 vocational education programs as part of Project ACCESS, a project to assess women's life experience learning for entrance into employment and for advanced placement in vocational education programs. Development of the occupational scales involved employer interviews, followed…

  18. EPA construction grants: Information on the Milwaukee Area Sewerage System Improvement Program

    SciTech Connect

    Not Available

    1986-01-01

    The Milwaukee Sewerage Water Pollution Abatement Program was initiated in response to federal and state court lawsuits to halt Lake Michigan's pollution. It is about $360 million under budget and on schedule with a 1996 target completion date. GAO found that the district meets the federal criteria for an eligible grantee; federal and Wisconsin regulations permit architect and engineering contracts to be competitively negotiated and do not require advertised competitive bidding; the job site rule, which limits allowable overhead billings, was not applied because it was determined that the operation of the prime contractor responsible for managing the program and its technical integrity did not constitute a job site; no federal funds have been involved in the disposition of rock from the north shore project site; and the total estimated architect and engineering costs $344.7 million represent about 28 percent of total estimated construction costs.

  19. 25 CFR 1000.242 - What provisions relating to a construction program may be included in an AFA?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... included in an AFA? 1000.242 Section 1000.242 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program may be included in an AFA? The Secretary and the Tribe/Consortium may negotiate to apply... to a construction part of an AFA. Absent a negotiated agreement, such provisions and...

  20. 25 CFR 1000.242 - What provisions relating to a construction program may be included in an AFA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... included in an AFA? 1000.242 Section 1000.242 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program may be included in an AFA? The Secretary and the Tribe/Consortium may negotiate to apply... to a construction part of an AFA. Absent a negotiated agreement, such provisions and...

  1. 25 CFR 1000.242 - What provisions relating to a construction program may be included in an AFA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... included in an AFA? 1000.242 Section 1000.242 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program may be included in an AFA? The Secretary and the Tribe/Consortium may negotiate to apply... to a construction part of an AFA. Absent a negotiated agreement, such provisions and...

  2. 25 CFR 1000.242 - What provisions relating to a construction program may be included in an AFA?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... included in an AFA? 1000.242 Section 1000.242 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program may be included in an AFA? The Secretary and the Tribe/Consortium may negotiate to apply... to a construction part of an AFA. Absent a negotiated agreement, such provisions and...

  3. 25 CFR 1000.242 - What provisions relating to a construction program may be included in an AFA?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... included in an AFA? 1000.242 Section 1000.242 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS... construction program may be included in an AFA? The Secretary and the Tribe/Consortium may negotiate to apply... to a construction part of an AFA. Absent a negotiated agreement, such provisions and...

  4. Employers' Perception of Graduates with Entry-Level Technical Skills from Construction Industry Programs in Ghana and Nigeria

    ERIC Educational Resources Information Center

    Acheampong, Philip

    2013-01-01

    The purpose of this comparative study was to identify the technical skills and abilities needed by prospective employees of construction industries in Ghana and Nigeria. Potential employees were defined here as recent graduates of construction industry programs with entry-level technical skills. The continuous growth in and expansion of these two…

  5. Scientific program construction principles and time allocation scheme for the World Space Observatory—Ultraviolet mission

    NASA Astrophysics Data System (ADS)

    Malkov, Oleg; Sachkov, Mikhail; Shustov, Boris; Kaigorodov, Pavel; Yáñez, Francisco Javier; Gómez de Castro, Ana Ines

    2011-09-01

    We present scientific program construction principles and a time allocation scheme developed for the World Space Observatory—Ultraviolet (WSO-UV) mission, which is an international space observatory for observation in UV spectral range 100-300 nm. The WSO-UV consists of a 1.7 m aperture telescope with instrumentation designed to carry out high resolution spectroscopy, long-slit low resolution spectroscopy and direct sky imaging. The WSO-UV Ground Segment is under development by Spain and Russia. They will coordinate the Mission and Science Operations and provide the satellite tracking stations for the project. The WSO-UV will work as a targeted scientific observatory. Three scientific programs will be carried out at the observatory. Core Program of scientific observations, which deserves large amounts of observing time, will be defined by the WSO-UV Science Committee to allow the conduction of high impact or legacy scientific projects. Funding Bodies Program is the guaranteed time granted to each one of the national bodies funding the WSO-UV project. Guest observer program for everyone, or Open Program, consists of astronomical observations obtained with the WSO-UV by astronomers who may or may not belong to the WSO-UV international consortium. It is open to excellent scientific projects from the world-wide community and occupies up to 40% of total observational time. Apart from the particularities associated to a science mission, this new mission will be affected by a new concept of observations management, trying to maximize the scientific return of this mission, and the shared operations between the two sites located in Spain and Russia. A brief summary of the algorithmic strategies analyzed for scheduling optimization is also given in the paper.

  6. 1975-76 Pennsylvania Adult Basic Education Assessment Project: An Examination of the APL Construct and Mezirow's Program Evaluation Model as a Basis for Program Improvement. Final Report.

    ERIC Educational Resources Information Center

    Lindsay, Carl A.; And Others

    A project was conducted in Pennsylvania to determine what changes might improve the effectiveness of the State's adult basic education (ABE) program. Northcutt's construct of functional competency adult performance level (APL) and Mezirow's program evaluation model provided the basis for the project's two components: APL assessment and program…

  7. Construction of Engineering Education Program based on the Alumni's Evaluation of the Educational Outcome

    NASA Astrophysics Data System (ADS)

    Tsukamoto, Takehiko; Nishizawa, Hitoshi

    The Department of Electrical and Electronic Engineering in Toyota National College of Technology has put great emphasis on fundamental subjects, such as “electrical and electronic circuit" and “electromagnetism" more than 40 years. On the other hand, several issues of our college were clarified by the alumni's evaluation of the educational outcome in 2002. The most serious issue was low achievement of English and Social education. The alumni of all generation are dissatisfied with their low skill in English communication. As a part of the educational reforms, our department has constructed a new engineering education program focusing on fundamental ability. We introduced many problem-based-learning experiments and the compulsory subjects such as “English communication for electrical engineers" and “Engineering Ethics" into this program. Great educative results are obtained by these improvements. As a typical example, the scores of all 2nd grade students of advanced engineering course in TOEIC tests became 450 points or more. Our program has been authorized by JABEE since 2004.

  8. The cultural construction of interdisciplinarity: Doctoral student socialization in an interdisciplinary neuroscience program

    NASA Astrophysics Data System (ADS)

    Holley, Karri A.

    Using the methodologies of individual and group interviews, observation, and document analysis, this dissertation examines the experiences of doctoral students enrolled in an interdisciplinary neuroscience program. A framework drawn from theories of organizational socialization is employed to understand the influence of an interdisciplinary program on doctoral student socialization. While abundant previous literature exists in regards to the socialization of doctoral students, such literature largely concentrates the disciplinary experience. The escalating import of globalization and shifting fiscal realities place new demands on Ph.D. programs and doctoral students to work as part of collaborative research teams, produce interdisciplinary knowledge, and integrate theory and practice. The increasing influence of such factors requires a new focus on interdisciplinarity and the changing Ph.D. The goal of this dissertation is to expand the existing framework of socialization by documenting the influence of such obstacles on knowledge acquisition, identity development, and professional investment. This study focuses on how interdisciplinary identities are constructed by doctoral students through individual interaction with the social environment and cultural context. Particular attention is given to the structural and cultural obstacles that doctoral students must negotiate as they navigate an interdisciplinary program. The study expands on the previous literature regarding doctoral student socialization by focusing on identity development, specifically a student's symbolic identity as a neuroscientist, a student's disciplinary identity (related to her professional background and undergraduate experiences), and a multi-disciplinary identity that allows for connections across disciplinary boundaries. In contrast to the traditional concepts of identity which focus on boundaries and differences as an inherent part of self-definition, the structure of identity advanced

  9. 29 CFR 2575.502c-1 - Adjusted civil penalty under section 502(c)(1).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ACT OF 1974 ADJUSTMENT OF CIVIL PENALTIES UNDER ERISA TITLE I Adjustment of Civil Penalties Under ERISA Title I § 2575.502c-1 Adjusted civil penalty under section 502(c)(1). In accordance with the... section 502(c)(1) of the Employee Retirement Income Security Act of 1974, as amended (ERISA), is...

  10. 29 CFR 2575.502c-1 - Adjusted civil penalty under section 502(c)(1).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ACT OF 1974 ADJUSTMENT OF CIVIL PENALTIES UNDER ERISA TITLE I Adjustment of Civil Penalties Under ERISA Title I § 2575.502c-1 Adjusted civil penalty under section 502(c)(1). In accordance with the... section 502(c)(1) of the Employee Retirement Income Security Act of 1974, as amended (ERISA), is...

  11. 29 CFR 2575.502c-1 - Adjusted civil penalty under section 502(c)(1).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACT OF 1974 ADJUSTMENT OF CIVIL PENALTIES UNDER ERISA TITLE I Adjustment of Civil Penalties Under ERISA Title I § 2575.502c-1 Adjusted civil penalty under section 502(c)(1). In accordance with the... section 502(c)(1) of the Employee Retirement Income Security Act of 1974, as amended (ERISA), is...

  12. 29 CFR 2575.502c-1 - Adjusted civil penalty under section 502(c)(1).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ACT OF 1974 ADJUSTMENT OF CIVIL PENALTIES UNDER ERISA TITLE I Adjustment of Civil Penalties Under ERISA Title I § 2575.502c-1 Adjusted civil penalty under section 502(c)(1). In accordance with the... section 502(c)(1) of the Employee Retirement Income Security Act of 1974, as amended (ERISA), is...

  13. Some theoretical models and constructs generic to substance abuse prevention programs for adolescents: possible relevance and limitations for problem gambling.

    PubMed

    Evans, Richard I

    2003-01-01

    For the past several years the author and his colleagues have explored the area of how social psychological constructs and theoretical models can be applied to the prevention of health threatening behaviors in adolescents. In examining the need for the development of gambling prevention programs for adolescents, it might be of value to consider the application of such constructs and theoretical models as a foundation to the development of prevention programs in this emerging problem behavior among adolescents. In order to provide perspective to the reader, the present paper reviews the history of various psychosocial models and constructs generic to programs directed at prevention of substance abuse in adolescents. A brief history of some of these models, possibly most applicable to gambling prevention programs, are presented. Social inoculation, reasoned action, planned behavior, and problem behavior theory, are among those discussed. Some deficits of these models, are also articulated. How such models may have relevance to developing programs for prevention of problem gambling in adolescents is also discussed. However, the inherent differences between gambling and more directly health threatening behaviors such as substance abuse must, of course, be seriously considered in utilizing such models. Most current gambling prevention programs have seldom been guided by theoretical models. Developers of gambling prevention programs should consider theoretical foundations, particularly since such foundations not only provide a guide for programs, but may become critical tools in evaluating their effectiveness.

  14. SLE and C1q: A quantitative ELISA for determining C1q levels in serum

    PubMed Central

    Dillon, Skyler P.; D’Souza, Anil; Kurien, Biji T.; Scofield, R. Hal

    2010-01-01

    C1q is of interest in SLE research due to deficiencies in its activity being associated with the disease. Current published protocols for measuring C1q vary greatly in their results and ease of reproducibility. Due to this, average C1q concentrations have been reported between 56 and 276 µg/ml in non-SLE serum. We present an improved method for quantifying C1q concentrations that employs a sandwich ELISA. This method has improved precision, cost efficiency, up-scaling, reproducibility, and uses significantly lesser volumes of serum sample when compared to RID and other methods for quantifying C1q. We report an average concentration of 113±40 µg/ml for C1q in non-SLE serum. The assay designed here will be useful in the high-throughput measurement of serum C1q in SLE cases. PMID:19370710

  15. Hereditary angioedema with normal C1 inhibitor.

    PubMed

    Bork, Konrad

    2013-11-01

    Until recently it was assumed that hereditary angioedema was a disease that results exclusively from a genetic deficiency of the C1 inhibitor. In 2000, families with hereditary angioedema, normal C1 inhibitor activity, and protein in plasma were described. Since then, numerous patients and families with that condition have been reported. Most of the patients were women. In many of the affected women, oral contraceptives, hormone replacement therapy containing estrogens, and pregnancies triggered the clinical symptoms. In some families mutations in the coagulation factor XII (Hageman factor) gene were detected.

  16. C1 Hermite shape preserving polynomial splines in R3

    NASA Astrophysics Data System (ADS)

    Gabrielides, Nikolaos C.

    2012-06-01

    The C 2 variable degree splines1-3 have been proven to be an efficient tool for solving the curve shape-preserving interpolation problem in two and three dimensions. Based on this representation, the current paper proposes a Hermite interpolation scheme, to construct C 1 shape-preserving splines of variable degree. After this, a slight modification of the method leads to a C 1 shape-preserving Hermite cubic spline. Both methods can easily be developed within a CAD system, since they compute directly (without iterations) the B-spline control polygon. They have been implemented and tested within the DNV Software CAD/CAE system GeniE. [Figure not available: see fulltext.

  17. Terminal complement complexes and C1/C1 inhibitor complexes in autoimmune thyroid disease.

    PubMed Central

    Weetman, A P; Cohen, S B; Oleesky, D A; Morgan, B P

    1989-01-01

    The potential role of complement activation and the membrane attack complex in the pathogenesis of Graves' disease and Hashimoto's thyroiditis has been investigated by measuring serum concentrations of the C1r-C1s-C1 inhibitor complex (C1/C1-inh) and the terminal complement complex (TCC), and by studying the binding to thyroid tissue of monoclonal and polyclonal antibodies against TCC neoantigens. Serum C1/C1-inh and TCC concentrations were significantly increased in 29 patients with untreated Graves' disease compared with 47 healthy subjects (P less than 0.001 for both), and decreased significantly after carbimazole treatment in 18 of these patients for whom post-treatment samples were available (P less than 0.01 and P less than 0.02, respectively). The serum TCC concentration, but not that of C1/C1-inh, was also significantly increased in 15 patients with Hashimoto's thyroiditis compared with the 47 healthy subjects (P less than 0.001). TCCs were identified by immunohistochemical staining around the thyroid follicles in thyroidectomy specimens from patients with Graves' disease (six out of six) and Hashimoto's thyroiditis (two out of two); normal thyroid tissue from two subjects showed no staining. These results suggest a role for complement, in particular the membrane attack complex in the pathogenesis of autoimmune thyroid disease. Images Fig. 3 PMID:2766576

  18. Non-Native English-Speaking Teachers' Negotiations of Program Discourses in Their Construction of Professional Identities within a TESOL Program

    ERIC Educational Resources Information Center

    Ilieva, Roumi

    2010-01-01

    The professional identity of language teachers has gained prominence in research on language instruction in the last decade. This article adds to work by critically exploring how teacher education programs allow non-native English-speaking teachers (NNESTs) to construct positive professional identities and become pro-active educators. It reports…

  19. Satellite Power System. Concept development and evaluation program, volume 6: Construction and operations

    NASA Technical Reports Server (NTRS)

    Benson, H.; Jenkins, L. M.

    1981-01-01

    The construction, operation, and maintenance requirements for a solar power satellite, including the space and ground systems, are reviewed. The basic construction guidelines are explained, and construction location options are discussed. The space construction tasks, equipment, and base configurations are discussed together with the operations required to place a solar power satellite in geosynchronous orbit. A rectenna construction technique is explained, and operation with the grid is defined. Maintenance requirements are summarized for the entire system. Key technology issues required for solar power satellite construction operations are defined.

  20. Constructing Programming Tests from an Item Pool: Pushing the Limits of Student Knowledge Using Assessment and Learning Analytics

    ERIC Educational Resources Information Center

    Ivancevic, Vladimir

    2014-01-01

    Tests targeting the upper limits of student ability could aid students in their learning. This article gives an overview of an approach to the construction of such tests in programming, together with ideas on how to implement and refine them within a learning management system.

  1. Men's Adultery as Sickness: Metaphor, Gender Categories and the Discursive Construction of Gender Differences on Japanese Television Consultation Programs

    ERIC Educational Resources Information Center

    Saft, Scott; Ohara, Yumiko

    2009-01-01

    This article describes how Japanese TV programs adopting a consultation framework construct different realities for women and men concerning a specific social phenomenon, namely adultery. To do so, two perspectives, the theory of metaphor promoted by George Lakoff and membership category analysis, are combined toward a discursive analysis which…

  2. The Construction and Evaluation of a Programed Course in Mathematics Necessary for Success in Collegiate Physical Science

    ERIC Educational Resources Information Center

    Collagan, Robert B.

    1969-01-01

    Discusses the construction and evaluation of a programed course in mathematics designed to provide remedial instruction to college freshmen who scored below the 25th percentile on the ACT examination. The study involved 200 students at Morgan State College, Maryland. Dependent variables were scores on several mathematics and physics tests given…

  3. "The Mall" and "the Plant": Choice and the Classed Construction of Possible Futures in Two Specialized Arts Programs

    ERIC Educational Resources Information Center

    Gaztambide-Fernández, Rubén; VanderDussen, Elena; Cairns, Kate

    2014-01-01

    This article explores how conceptions of choice and visions of the future are constructed within the context of specialized arts programs in two Canadian public high schools. The authors consider how discourses of the arts are implicated in the way that possible futures are envisioned differently, delimiting the range of choices available to…

  4. A Study of the Construct Validity of Six Vocational Achievement Tests in the Ohio Vocational Education Achievement Test Program.

    ERIC Educational Resources Information Center

    Hines, Constance V.; And Others

    A study examined the construct validity of six vocational achievement tests used in the Ohio Vocational Achievement Testing Program. (Subject areas covered in the tests were agricultural mechanics, carpentry, diesel mechanics, distributive education for food services personnel, fabric services, and home economics/food service.) In order to…

  5. When the School Bell Rings... Juvenile Crime or Constructive Time? After-School Programs Are the Answer.

    ERIC Educational Resources Information Center

    Carpenter, Tim; Cornelius, Aisha; Francis, Ann Potter; Parsons, Lena

    Noting that the after-school hours are peak hours for Illinois juveniles to be either victims of crime or involved in criminal activity, this report provides evidence that making quality after-school programs available to all youth who need them will reduce crime and provide constructive activities for youth. The report details statistics on…

  6. RECOMMENDED FOUNDATION BARRIER CONSTRUCTION STANDARD OF THE FLORIDA RADON RESEARCH PROGRAM

    EPA Science Inventory

    The report give results of a study to determine the causes of cracking in slab-on-grade construction, particularly for single-family residential structures in Florida, and to recommend a foundation barrier construction standard to minimize such cracking.

  7. Lessons learned from new construction utility demand side management programs and their implications for implementing building energy codes

    SciTech Connect

    Wise, B.K.; Hughes, K.R.; Danko, S.L.; Gilbride, T.L.

    1994-07-01

    This report was prepared for the US Department of Energy (DOE) Office of Codes and Standards by the Pacific Northwest Laboratory (PNL) through its Building Energy Standards Program (BESP). The purpose of this task was to identify demand-side management (DSM) strategies for new construction that utilities have adopted or developed to promote energy-efficient design and construction. PNL conducted a survey of utilities and used the information gathered to extrapolate lessons learned and to identify evolving trends in utility new-construction DSM programs. The ultimate goal of the task is to identify opportunities where states might work collaboratively with utilities to promote the adoption, implementation, and enforcement of energy-efficient building energy codes.

  8. Combined traumatic occiput-C1 and C1-C2 dissociation: 2 case reports.

    PubMed

    Gould, Stephen; Hishmeh, Shuriz; McKinney, Bart; Stephen, Mark

    2010-08-01

    Occiput-C1 and C1-C2 dissociations and dislocations have been well documented in the literature. However, after thorough review of the literature, we found very little in the literature regarding combined occiput-C1 and C1-C2 dissociations in adults who survived. We present 2 case reports describing the clinical presentation, initial management, operative treatment, and postoperative course of 2 patients who sustained traumatic combined occiput-C1 and C1-C2 dissociations. After initial stabilization, both patients underwent open reduction and posterior occipital-cervical fusion with segmental fixation. At recent follow-up, both patients maintain good sagittal alignment without loss of reduction, and they have radiographic progression to fusion, minimal pain, and improved neurologic function. Combined occiput-C1 and C1-C2 dissociations are rare but serious injuries. Incomplete dissociations may not be evident on initial radiographs. Computed tomography or magnetic resonance imaging is recommended for formal diagnosis. A traumatic dural tear may be present. We recommend open reduction and posterior occipital-cervical fusion with segmental fixation for these patients.

  9. Using a commercial CAD system for simultaneous input to theoretical aerodynamic programs and wind-tunnel model construction

    NASA Technical Reports Server (NTRS)

    Enomoto, F.; Keller, P.

    1984-01-01

    The Computer Aided Design (CAD) system's common geometry database was used to generate input for theoretical programs and numerically controlled (NC) tool paths for wind tunnel part fabrication. This eliminates the duplication of work in generating separate geometry databases for each type of analysis. Another advantage is that it reduces the uncertainty due to geometric differences when comparing theoretical aerodynamic data with wind tunnel data. The system was adapted to aerodynamic research by developing programs written in Design Analysis Language (DAL). These programs reduced the amount of time required to construct complex geometries and to generate input for theoretical programs. Certain shortcomings of the Design, Drafting, and Manufacturing (DDM) software limited the effectiveness of these programs and some of the Calma NC software. The complexity of aircraft configurations suggests that more types of surface and curve geometry should be added to the system. Some of these shortcomings may be eliminated as improved versions of DDM are made available.

  10. Improving safety climate through a communication and recognition program for construction: a mixed-methods study

    PubMed Central

    Sparer, Emily H; Catalano, Paul J; Herrick, Robert F; Dennerlein, Jack T

    2016-01-01

    Objectives This study aimed to evaluate the efficacy of a safety communication and recognition program (B-SAFE), designed to encourage improvement of physical working conditions and hazard reduction in construction. Methods A matched pair cluster randomized controlled trial was conducted on eight worksites (four received the B-SAFE intervention, four served as control sites) for approximately five months per site. Pre- and post-exposure worker surveys were collected at all sites (N=615, pre-exposure response rate of 74%, post-exposure response rate of 88%). Multi-level mixed-effect regression models evaluated the effect of B-SAFE on safety climate as assessed from surveys. Focus groups (N=6–8 workers/site) were conducted following data collection. Transcripts were coded and analyzed for thematic content using Atlas.ti (version 6). Results The mean safety climate score at intervention sites, as measured on a 0–50 point scale, increased 0.5 points (1%) between pre- and post-B-SAFE exposure, compared to control sites that decreased 0.8 points (1.6%). The intervention effect size was 1.64 (3.28%) (P-value=0.01) when adjusted for month the worker started on-site, total length of time on-site, as well as individual characteristics (trade, title, age, and race/ethnicity). At intervention sites, workers noted increased levels of safety awareness, communication, and teamwork compared to control sites. Conclusions B-SAFE led to many positive changes, including an improvement in safety climate, awareness, teambuilding, and communication. B-SAFE was a simple intervention that engaged workers through effective communication infrastructures and had a significant, positive effect on worksite safety. PMID:27158914

  11. Department of the Navy. FY 1994/FY 1995 Biennial Budget Estimates. Military Construction Program. FY 1994

    DTIC Science & Technology

    1992-01-01

    APPROPRIATIONS . - (NON-ADD)( 6,400) p 10. DESCRIPTION OF PROPOSED CONSTRUCTION Two-story reinforced concrete and masonry building, pile foundation, brick... concrete and masonry addition on concrete slab, built-up roof. air conditioning. sound attenuation, raised computer flooring, utilities. fire protection...CONSTRUCTION Permanent-type construction. concrete foundation walls, footing and concrete floors, masonry walls; interior control room with special lighting

  12. Charge density influences C1 domain ligand affinity and membrane interactions

    PubMed Central

    Lewin, Nancy E.; Kedei, Noemi; Hill, Colin S.; Selezneva, Julia S.; Valle, Christopher J.; Woo, Wonhee; Gorshkova, Inna; Blumberg, Peter M.

    2014-01-01

    The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analog the phorbol esters, has emerged as a promising therapeutic target for cancer and other indications. Potential target selectivity is markedly enhanced both because binding reflects ternary complex formation between ligand, the C1 domain, and phospholipid, and because binding drives membrane insertion of the C1 domain, permitting aspects of the C1 domain surface outside the binding site per se to influence binding energetics. Here, focusing on charged residues identified in atypical C1 domains which contribute to their loss of ligand binding activity, we show that increasing charge along the rim of the binding cleft of the protein kinase C δ C1b domain raises the requirement for anionic phospholipids. Correspondingly, it shifts the selectivity of C1 domain translocation to the plasma membrane, which is more negatively charged than internal membranes. This change in localization is most pronounced in the case of more hydrophilic ligands, which provide weaker membrane stabilization than do the more hydrophobic ligands, and thus contributes an element to the structure activity relations for C1 domain ligands. Co-expressing pairs of C1 containing constructs with differing charges each expressing a distinct fluorescent tag provided a powerful tool to demonstrate the effect of increasing charge in the C1 domain. PMID:24777910

  13. Linear programming model to construct phylogenetic network for 16S rRNA sequences of photosynthetic organisms and influenza viruses.

    PubMed

    Mathur, Rinku; Adlakha, Neeru

    2014-06-01

    Phylogenetic trees give the information about the vertical relationships of ancestors and descendants but phylogenetic networks are used to visualize the horizontal relationships among the different organisms. In order to predict reticulate events there is a need to construct phylogenetic networks. Here, a Linear Programming (LP) model has been developed for the construction of phylogenetic network. The model is validated by using data sets of chloroplast of 16S rRNA sequences of photosynthetic organisms and Influenza A/H5N1 viruses. Results obtained are in agreement with those obtained by earlier researchers.

  14. Libby Mitigation Program, 2007 Annual Progress Report: Mitigation for the Construction and Operation of Libby Dam.

    SciTech Connect

    Dunnigan, James; DeShazer, J.; Garrow, L.

    2009-05-26

    basin streams and lakes. 'Mitigation for the Construction and Operation of Libby Dam' is part of the Northwest Power and Conservation Council's (NPCC) resident fish and wildlife program. The program was mandated by the Northwest Planning Act of 1980, and is responsible for mitigating damages to fish and wildlife caused by hydroelectric development in the Columbia River Basin. The objective of Phase I of the project (1983 through 1987) was to maintain or enhance the Libby Reservoir fishery by quantifying seasonal water levels and developing ecologically sound operational guidelines. The objective of Phase II of the project (1988 through 1996) was to determine the biological effects of reservoir operations combined with biotic changes associated with an aging reservoir. The objectives of Phase III of the project (1996 through present) are to implement habitat enhancement measures to mitigate for dam effects, to provide data for implementation of operational strategies that benefit resident fish, monitor reservoir and river conditions, and monitor mitigation projects for effectiveness. This project completes urgent and high priority mitigation actions as directed by the Kootenai Subbasin Plan.

  15. Department of the Navy Justification of Estimates FY 1991 Budget Estimates Submitted to Congress January 1990: Military Construction & Family Housing Program

    DTIC Science & Technology

    1990-01-01

    NAVY FY 1991 MILITARY CONSTRUCTION AND FAMILY HOUSING PROGRAM TABLE OF CONTENTS STATE LIST ............................ TAB "A" MISSION STATUS INDEX ...TAB "B" INSTALLATION INDEX ........... ........................ .TAB "C" BUDGET APPENDIX EXTRACT...ii m~mlll m~ =m • • • • • • DEPARTMENT OF THE NAVY FY 1991 MILITARY CONSTRUCTION AND FAMILY HOUSING PROGRAM INDEX OF LOCATIONS - AUTH. APPROP

  16. Theoretical Insights into C1 Surface Chemistry

    NASA Astrophysics Data System (ADS)

    Neurock, Matthew

    2008-03-01

    Reforming and partial oxidation of methane as well as other C1 fuels are important processes in the production of hydrogen and synthesis gas and will likely play important roles future energy strategies. Herein we use theory and simulation to examine the reactivity of methane, methanol and dimethyl ether with CO2, H2O, or O2 over supported transition metals. We systematically probe the elementary C-H bond activation as well as the oxidation pathways involved in both reforming as the oxidation of methane and other C1 intermediates over well defined transition metal surfaces, metal alloys and metal nanoparticles. The calculations demonstrate well-established trends in C-H bond activation as the result of changes in the metal, the activating molecule (methane, methanol, and DME) as well as the reaction conditions. The reaction conditions ultimately dictate the surface coverage of carbon and oxygen which have important consequences on the surface reactivity. The theoretical and simulation results are compared with well defined experiments carried out at Berkeley over supported particles.

  17. Computer program analyzes Buckling Of Shells Of Revolution with various wall construction, BOSOR

    NASA Technical Reports Server (NTRS)

    Almroth, B. O.; Bushnell, D.; Sobel, L. H.

    1968-01-01

    Computer program performs stability analyses for a wide class of shells without unduly restrictive approximations. The program uses numerical integration, finite difference of finite element techniques to solve with reasonable accuracy almost any buckling problem for shells exhibiting orthotropic behavior.

  18. Successfully Implementing Net-Zero Energy Policy through the Air Force Military Construction Program

    DTIC Science & Technology

    2013-03-01

    energy building , historical data cannot be used to provide an accurate parametric estimate. Since adequate historical 76 data does not exist...2012). Due to the natural variability in construction and the limited data available regarding the construction premium required to achieve a low

  19. The Use of Linear (Goal) Programming in the Construction of a Test Blueprint.

    ERIC Educational Resources Information Center

    Busch, John Christian; Taylor, Raymond G.

    The use of a variation of linear programing (goal programing) to develop a test blueprint with multiple specification requirements, is the topic of this paper. The computer program STORM was used to develop a table of test specifications for a test that would measure achievement in introductory statistics in the subdomains of frequency…

  20. Constructing the ScratchJr Programming Language in the Early Childhood Classroom

    ERIC Educational Resources Information Center

    Portelance, Dylan J.; Strawhacker, Amanda L.; Bers, Marina Umaschi

    2016-01-01

    This paper seeks to contribute to the growing literature on children and computer programming by focusing on a programming language for children in Kindergarten through second grade. Sixty-two students were exposed to a 6-week curriculum using ScartchJr. They learned foundational programming concepts and applied those concepts to create personally…

  1. Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

    PubMed Central

    Bally, Isabelle; Ancelet, Sarah; Moriscot, Christine; Gonnet, Florence; Mantovani, Alberto; Daniel, Régis; Schoehn, Guy; Arlaud, Gérard J.; Thielens, Nicole M.

    2013-01-01

    Complement C1q is a hexameric molecule assembled from 18 polypeptide chains of three different types encoded by three genes. This versatile recognition protein senses a wide variety of immune and nonimmune ligands, including pathogens and altered self components, and triggers the classical complement pathway through activation of its associated proteases C1r and C1s. We report a method for expression of recombinant full-length human C1q involving stable transfection of HEK 293-F mammalian cells and fusion of an affinity tag to the C-terminal end of the C chain. The resulting recombinant (r) C1q molecule is similar to serum C1q as judged from biochemical and structural analyses and exhibits the characteristic shape of a bunch of flowers. Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s-C1r-C1r-C1s tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3, and to trigger C1r and C1s activation. Functional analysis of rC1q variants carrying mutations of LysA59, LysB61, and/or LysC58, in the collagen-like stems, demonstrates that LysB61 and LysC58 each play a key role in the interaction with C1s-C1r-C1r-C1s, with LysA59 being involved to a lesser degree. We propose that LysB61 and LysC58 both form salt bridges with outer acidic Ca2+ ligands of the C1r and C1s CUB (complement C1r/C1s, Uegf, bone morphogenetic protein) domains. The expression method reported here opens the way for deciphering the molecular basis of the unusual binding versatility of C1q by mapping the residues involved in the sensing of its targets and the binding of its receptors. PMID:23650384

  2. An Evaluation of the Right Choices Program to Determine Effectiveness in Delivering Constructive Interventions and Providing an Early Support Program in Order to Modify Behavior of First-Time Student Offenders Who Commit Drug and Violent Acts

    ERIC Educational Resources Information Center

    Barnes, Lisa B.

    2010-01-01

    The purpose of the study was to perform a program evaluation of the Right Choices Program to determine the program's effectiveness in delivering constructive interventions that modify student behavior once students have left the program and have returned to their regular learning environment. This mixed-method evaluation consisted of an…

  3. 45 CFR 1706.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION...

  4. 45 CFR 1706.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION...

  5. 45 CFR 2490.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.151...

  6. 45 CFR 2490.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION § 2490.151...

  7. 45 CFR 1706.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION...

  8. 45 CFR 1706.151 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION...

  9. Hereditary C1q deficiency: a new family with C1qA deficiency.

    PubMed

    Sun-Tan, Cağman; Ozgür, Tuba Turul; Kilinç, Gamze; Topaloğlu, Rezan; Gököz, Ozay; Ersoy-Evans, Sibel; Sanal, Ozden

    2010-01-01

    Hereditary deficiency of complement component C1q is a rare genetic disorder with susceptibility to recurrent infections with polysaccharide-containing encapsulated microorganisms and a high prevalence of autoimmune diseases, most often systemic lupus erythematosus (SLE). Here, we report a 29-month-old boy who presented with facial rash and history of early death of a sibling with infections, who was found to have a selective deficiency of C1q. The facial rash was composed of patchy erythematous plaques and centrally hypopigmented macules and desquamation. Two siblings had died of severe bacterial infections and his uncle had died of meningitis. Molecular study disclosed a homozygous point mutation in the C1qA chain gene. Five members of the family, including the parents and three healthy siblings, were heterozygous for this mutation.

  10. 40 CFR 63.42 - Program requirements governing construction or reconstruction of major sources.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Accordance With Clean Air Act Sections, Sections 112(g) and 112(j) § 63.42 Program requirements governing... cause by EPA to apply the sanctions and remedies set forth in the Clean Air Act section 502(I). (c... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

  11. 40 CFR 63.42 - Program requirements governing construction or reconstruction of major sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Accordance With Clean Air Act Sections, Sections 112(g) and 112(j) § 63.42 Program requirements governing... cause by EPA to apply the sanctions and remedies set forth in the Clean Air Act section 502(I). (c... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

  12. 40 CFR 63.42 - Program requirements governing construction or reconstruction of major sources.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Accordance With Clean Air Act Sections, Sections 112(g) and 112(j) § 63.42 Program requirements governing... cause by EPA to apply the sanctions and remedies set forth in the Clean Air Act section 502(I). (c... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

  13. 10 CFR 4.551 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....551 Section 4.551 Energy NUCLEAR REGULATORY COMMISSION NONDISCRIMINATION IN FEDERALLY ASSISTED PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE COMMISSION Enforcement of Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the U.S. Nuclear...

  14. 77 FR 28573 - Applications for New Awards; Impact Aid Discretionary Construction Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... grant award under this competition. b. Supplement-Not-Supplant: As outlined in 34 CFR 222.174, grants made under this program are subject to supplement, not supplant funding provisions. Grant funds under... following address: U.S. Department of Education, Impact Aid Program, Attention: (CFDA Number 84.041C),...

  15. Evaluating the Facilities Planning, Design, and Construction Department: The Capital Programs Management Audit.

    ERIC Educational Resources Information Center

    Kaiser, Harvey H.; Kirkwood, Dennis M.

    2000-01-01

    Presents a diagnostic model for assessing the state of an institution's capital programs management (CPM) by delineating "work processes" which comprise that function. What capital programs management is, its resources, and its phases and work processes are described, followed by case studies of the CPM Process Model as an assessment tool. (GR)

  16. Indigenous Worldviews in Intercultural Education: Teachers' Construction of Interculturalism in a Bilingual Quechua-Spanish Program

    ERIC Educational Resources Information Center

    Valdiviezo, Laura Alicia

    2010-01-01

    This paper examines teachers' implementation of a bilingual intercultural education (BIE) program in Peru. This program is inspired by global policies that promote cultural pluralism and educational access to marginalized indigenous populations. Broadly addressed in policy in Andean countries, interculturalism in Peru has remained a core…

  17. 42 CFR 52c.1 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH... Biomedical Research Support Program) awarded in accordance with section 301(a)(3) of the Public Health... investigators engaged in biomedical research, and to broaden the opportunities for participation in...

  18. 42 CFR 52c.1 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH... Biomedical Research Support Program) awarded in accordance with section 301(a)(3) of the Public Health... investigators engaged in biomedical research, and to broaden the opportunities for participation in...

  19. 42 CFR 52c.1 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH... Biomedical Research Support Program) awarded in accordance with section 301(a)(3) of the Public Health... investigators engaged in biomedical research, and to broaden the opportunities for participation in...

  20. 42 CFR 52c.1 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH... Biomedical Research Support Program) awarded in accordance with section 301(a)(3) of the Public Health... investigators engaged in biomedical research, and to broaden the opportunities for participation in...

  1. 42 CFR 52c.1 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS MINORITY BIOMEDICAL RESEARCH... Biomedical Research Support Program) awarded in accordance with section 301(a)(3) of the Public Health... investigators engaged in biomedical research, and to broaden the opportunities for participation in...

  2. Characterization of C1 inhibitor binding to neutrophils.

    PubMed Central

    Chang, N S; Boackle, R J; Leu, R W

    1991-01-01

    In a previous study we have isolated neutrophil membrane proteins that non-covalently bind to native C1-INH (105,000 MW) and a non-functional, degraded C1-INH (88,000 MW; C1-INH-88). To further characterize the binding nature, we have designed a novel kinetic C1 titration assay which enables not only a quantification of the removal of fluid-phase C1-INH by neutrophils, but also a concomitant measure of residual C1-INH function. Native C1-INH, when adsorbed to EDTA-pretreated neutrophils, lost its function in the inhibition of fluid-phase C1. The non-functional C1-INH-88, which is probably devoid of a reactive centre, was found to block the binding of native C1-INH to neutrophils. Pretreatment of neutrophils with serine esterase inhibitors did not abrogate binding capacity of the cells for C1-INH, whereas the binding affinity for C1-INH was lost when the cells were pretreated with trypsin. An array of human peripheral blood leucocytes and several lymphoid cell lines has surface binding sites for C1-INH, but not on human erythrocytes and U937 cells. Binding was further confirmed using (i) C1-INH-microsphere beads to neutrophils, in which the binding was blocked when pretreating neutrophils with excess C1-INH or with trypsin, and (ii) radiolabelled C1-INH to neutrophils, which was competitively blocked by unlabelled non-functional C1-INH-88. Desialylation of C1-INH significantly reduced its binding affinity for neutrophils, indicating that the membrane receptor sites on neutrophils could be specific for the binding of sialic acid residues on C1-INH. Overall, our studies indicate that neutrophils or other leucocytes possess specific surface binding sites for the sialic acid-containing portion of C1-INH. PMID:2045131

  3. A Concept of Constructing a Common Information Space for High Tech Programs Using Information Analytical Systems

    NASA Astrophysics Data System (ADS)

    Zakharova, Alexandra A.; Kolegova, Olga A.; Nekrasova, Maria E.

    2016-04-01

    The paper deals with the issues in program management used for engineering innovative products. The existing project management tools were analyzed. The aim is to develop a decision support system that takes into account the features of program management used for high-tech products: research intensity, a high level of technical risks, unpredictable results due to the impact of various external factors, availability of several implementing agencies. The need for involving experts and using intelligent techniques for information processing is demonstrated. A conceptual model of common information space to support communication between members of the collaboration on high-tech programs has been developed. The structure and objectives of the information analysis system “Geokhod” were formulated with the purpose to implement the conceptual model of common information space in the program “Development and production of new class mining equipment - “Geokhod”.

  4. Citizen Oversight of Public School Construction Programs: In Search of Promising Practice.

    ERIC Educational Resources Information Center

    2003

    This paper asserts that one part of a comprehensive control system for school construction projects is a citizen oversight committee. It suggests that citizen oversight committees are a cost-effective and politically important method for supplementing a school board in its monitoring and oversight functions. Inaddition, the committee acts as a…

  5. 45 CFR 85.43 - Program accessibility: New construction and alterations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... U.S.C. 4151-4157) as established in 41 CFR 101-19.600 to 101-19.607 apply to buildings covered by... agency shall be designed, constructed, or altered so as to be readily accessible to and usable...

  6. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Balance of Payments... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7045 Balance of Payments... clause: Balance of Payments Program—Construction Material Under Trade Agreements (MAY 2012)...

  7. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Balance of Payments... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7045 Balance of Payments... clause: Balance of Payments Program—Construction Material Under Trade Agreements (NOV 2009)...

  8. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a)(1), use the following clause: Balance of Payments...

  9. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a), use the following clause: Balance of Payments...

  10. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Balance of Payments... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7045 Balance of Payments... clause: Balance of Payments Program—Construction Material Under Trade Agreements (JUN 2011)...

  11. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a)(1), use the following clause: Balance of Payments...

  12. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a)(1), use the following clause: Balance of Payments...

  13. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Balance of Payments... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7045 Balance of Payments... clause: Balance of Payments Program—Construction Material Under Trade Agreements (OCT 2013)...

  14. 48 CFR 252.225-7045 - Balance of Payments Program-Construction Material Under Trade Agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Balance of Payments... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7045 Balance of Payments... clause: Balance of Payments Program—Construction Material Under Trade Agreements (AUG 2013)...

  15. 48 CFR 252.225-7044 - Balance of Payments Program-Construction Material.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Balance of Payments... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.225-7044 Balance of Payments Program—Construction Material. As prescribed in 225.7503(a)(1), use the following clause: Balance of Payments...

  16. Predators of Knowledge Construction: Interpreting Students' Metacognition in an Amusement Park Physics Program

    ERIC Educational Resources Information Center

    Anderson, David; Nashon, Samson

    2007-01-01

    It is recognized widely that learning is a dynamic and idiosyncratic process of construction and reconstruction of concepts in response to new experiences. It is influenced by the learner's prior knowledge, motivation, and sociocultural context. This study investigated how year 11 and 12 physics students' metacognition influences the development…

  17. A TEACHING PROGRAM FOR INDUSTRIAL TECHNOLOGY, THE WORLD OF CONSTRUCTION. (TITLE SUPPLIED).

    ERIC Educational Resources Information Center

    Illinois Univ., Champaign.

    THE DAILY SCHEDULE IS GIVEN FOR THE INDUSTRIAL ARTS CURRICULUM PROJECT'S FIRST YEAR COURSE IN CONSTRUCTION. INFORMATION TOPICS AND ALLOTTED CLASSTIME ARE GIVEN FOR 170 DAYS OF INSTRUCTION. CATEGORIES IN THE SCHEDULE ARE -- (1) READING ASSIGNMENT, (2) WORKBOOK, (3) PRESENTATION, (4) DISCUSSION, (5) STUDENT ACTIVITY, (6) LAB MANUAL, (7) LAB…

  18. Construction Productivity Advancement Research (CPAR) Program. Performance of Concretes Proportioned with Pyrament Blended Cement

    DTIC Science & Technology

    1994-04-01

    and summarized in this report was part of a joint research program which was cost-shared by the USACE CPAR program and Pyrament/Lone Star Industries...multiyear joint research project on high- performance blended hydraulic cement products. This agreement was enacted within the Corps. Because of the...and admixtures to control setting and reduce the water requirement. The cement composition includes a number of features that depart significantly

  19. Classical complement pathway component C1q: purification of human C1q, isolation of C1q collagen-like and globular head fragments and production of recombinant C1q-derivatives. Functional characterization.

    PubMed

    Kojouharova, Mihaela

    2014-01-01

    The classical complement pathway (CCP) activation is a multimolecular complex, composed of three subcomponents namely C1q, C1r, and C1s. C1q is the recognition subunit of this complex and its binding to the specific targets leads to the formation of active C1, which in turn activates the CCP in an immunoglobulin-dependent or -independent manner. C1q is a hexameric glycoprotein composed of 18 polypeptide chains of three different types (A, B, and C), organized in two fragments-collagen-like (CLR) and globular head (gC1q) possessing different functional activity. The contemporary knowledge of the C1q structure allows the isolation and purification of a C1q molecule from serum by combination of different chromatography procedures including ion-exchange, size-exclusion, and affinity chromatography, as well as the isolation of CLR and gC1q by limited enzymatic hydrolysis of the native C1q molecule. In this chapter, we described methods for purification of human C1q and its CLR and gC1q fragments, as well as methods for their biochemical and functional characterization. The production and purification of recombinant C1q derivatives ghA, ghB, and ghC (globular fragments of the individual C1q chains) are also presented.

  20. Automatic planning and programming for robotic construction of planetary/lunar structures

    SciTech Connect

    Boissiere, P.T.

    1997-04-01

    Many difficult material handling needs exist in remote unstructured environments. Currently these operations are accomplished using personnel in direct contact with the hazards. A safe and cost-effective alternative to this approach is the use of intelligent robotic systems for the excavation, handling, transport and manipulation of materials during remote construction operations. A robotic system designed for these tasks has been developed at Sandia National Laboratories which successfully integrates computer controlled manipulation and mobility to deliver these needed robotic capabilities in remote applications such as planetary operations. The mobile robot, RETRVIR, incorporates advanced developments in the integration of sensors, advanced computing environments, and graphical user interfaces. The addition of these elements in the control of remotely operated equipment have shown great promise for reducing the cost of remote construction while providing faster and safer operations.

  1. Department of the Navy FY 1985 Military Construction & Family Housing Program.

    DTIC Science & Technology

    1984-02-01

    ADD ( 0) 10, OESCRIPT10N OF PROOSED CONSTRUCTION Alterations and modernization of two enlisted dining facilities to improve food service, equipment...relaxing atmosphere in the dining area. Upgrade outdated and obsolete food preparation equipment and support facilities. CURRET SITUATION: Existing dining...utilities; food preparation and serving areas; exercise area; confinement cells; and vocational shops for 345 inmates (300 men, 45 women); demolition of

  2. Assessing the construct validity of five nutrient profiling systems using diet modeling with linear programming.

    PubMed

    Clerfeuille, E; Vieux, F; Lluch, A; Darmon, N; Rolf-Pedersen, N

    2013-09-01

    Nutrient profiling classifies individual food products according to their nutrient content. According to the WHO (World Health Organization), validation is a key step in the development of a nutrient profiling system. The aim was to assess the construct validity of five European nutrient profiling systems (Choices, Keyhole, (AFSSA), European Commission (EC) system and FoodProfiler). Construct validity was assessed for each of the five-selected nutrient profiling systems by testing whether healthy foods (that is, identified as eligible by the system) make healthy diets, and unhealthy foods (that is, non-eligible) make unhealthy diets, using diet modeling. The AFSSA, EC and FoodProfiler systems were identified as valid, but differences in their levels of permissiveness suggested some misclassified food products. The two other systems failed the construct validity assessment. Among these three systems, the EC system is the less demanding in terms of nutritional information, it would, therefore, be the easiest to implement for regulating nutrition and health claims in Europe.

  3. Department of the Navy FY 1990/FY 1991 Biennial Budget Estimates. Military Construction and Family Housing Program FY 1991. Justification Data Submitted to Congress

    DTIC Science & Technology

    1989-01-01

    resources needed to provide military families with adequate housing either through the private cnmmunitv or in government quarters. Navy and Marine Corps...Department of the Navy DTIC .l.LECTE SFEB 2 3 9jJ FY 1990/FY 1991 BIENNIAL Lo BUDGET ESTIMATES 0 (N MILITARY CONSTRUCTION AND FAMILY HOUSING PROGRAM...SUPPORT ’.. . .. ..... 13 ........................ I-, LU STATE LIST Department of the Navy FY 1991 Military Construction and Family Housing Program Summary

  4. Application of Matrix Outcome Mapping to Constructively Align Program Outcomes and Course Outcomes in Higher Education

    ERIC Educational Resources Information Center

    Mazouz, Abdelkader; Crane, Keenan

    2013-01-01

    Establishing a link between Course Learning Outcomes (LOs) and Program Outcomes (POs) while assessing the course contents and delivery are among the most challenging issues in Higher Education. In the present study two forms were generated based on specific Course Learning Outcomes identified in the syllabus at the beginning of the teaching term:…

  5. 78 FR 13646 - Applications for New Awards; Impact Aid Discretionary Construction Grant Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... grant award under this competition. b. Supplement-Not-Supplant: As outlined in 34 CFR 222.174, this competition involves supplement-not-supplant funding requirements. Grant funds under this competition may not... of Education, Impact Aid Program, Attention: (CFDA Number 84.041C), Room 3C121, 400 Maryland...

  6. The Effectiveness of a Re-Constructed Leadership Program through the Eyes of the Stakeholders.

    ERIC Educational Resources Information Center

    Martin, Barbara N.; Johnson, Judy A.

    2002-01-01

    Report of a study of the leadership competencies of rural principals in Missouri who were prepared through the Interstate School Leaders Licensure Consortium Standards. Findings indicate that a standards-based program and collaboration between the training institution and public schools results in well-prepared leaders. (Contains 1 table and 17…

  7. Planning a Program of School Plant Construction. Research Report, School Plant Planning Series.

    ERIC Educational Resources Information Center

    Utah State Board of Education, Salt Lake City.

    The importance of long-term planning, and undesirable conditions resulting from failure to plan, are stressed. General procedures named as essential are--(1) the official approval of the Board of Education before the administration proceeds with long-range planning, (2) the design of the school plant around the educational program it is to serve,…

  8. An Exploratory Study of the Impact of College Student Leadership Programs upon the Construct of Mindfulness

    ERIC Educational Resources Information Center

    Horowitz, Rich

    2012-01-01

    Mindfulness is a key skill that produces the greater psychological awareness identified by most leadership scholars as being essential to effective leadership. This study conducted an exploratory assessment of the effectiveness of mindfulness-based cocurricular collegiate leadership programs through pre- and post-participation application of the…

  9. C1 inhibitor functional deficiency in systemic lupus erythematosus (SLE).

    PubMed Central

    Jazwinska, E C; Gatenby, P A; Dunckley, H; Serjeantson, S W

    1993-01-01

    C1 inhibitor (C1-inh) was assayed in eight SLE patients presenting with consistently low levels of intact C4. C1-inh antigenic levels were normal in all patients; however, the function of the C1-inh tested against C1s and C1r was variable and outside the normal functional range in seven of the eight patients. The molecular weight of patients' C1-inh protein was 105 kD, corresponding to the size of the intact molecule. The C1-inh gene was analysed in all patients. Restriction fragments generated with TaqI, PstI and HgiAI gave no indication of a major C1-inh gene rearrangement. Direct genomic sequencing of exon VIII revealed three polymorphic point mutations, but there were no changes from the normal gene in or around the reactive-centre residue of C1-inh. Furthermore, we found no evidence for a C1-inh autoantibody in patients which could affect normal C1-inh function in vitro. These results indicate that the etiology of C1-inh dysfunction in SLE is heterogeneous and distinct from that reported in either hereditary or acquired angioedema. PMID:8485912

  10. Construction safety program for the National Ignition Facility Appendix A: Safety Requirements

    SciTech Connect

    Cerruti, S.J.

    1997-01-14

    These rules apply to all LLNL employees, non-LLNL employees (including contract labor, supplemental labor, vendors, personnel matrixed/assigned from other National Laboratories, participating guests, visitors and students) and construction contractors/subcontractors. The General Safety and Health rules shall be used by management to promote accident prevention through indoctrination, safety and health training and on-the-job application. As a condition for contracts award, all contractors and subcontractors and their employees must certify on Form S & H A-1 that they have read and understand, or have been briefed and understand, the National Ignition Facility OCIP Project General Safety Rules.

  11. Construction of pore network models for Berea and Fontainebleau sandstones using non-linear programing and optimization techniques

    NASA Astrophysics Data System (ADS)

    Sharqawy, Mostafa H.

    2016-12-01

    Pore network models (PNM) of Berea and Fontainebleau sandstones were constructed using nonlinear programming (NLP) and optimization methods. The constructed PNMs are considered as a digital representation of the rock samples which were based on matching the macroscopic properties of the porous media and used to conduct fluid transport simulations including single and two-phase flow. The PNMs consisted of cubic networks of randomly distributed pores and throats sizes and with various connectivity levels. The networks were optimized such that the upper and lower bounds of the pore sizes are determined using the capillary tube bundle model and the Nelder-Mead method instead of guessing them, which reduces the optimization computational time significantly. An open-source PNM framework was employed to conduct transport and percolation simulations such as invasion percolation and Darcian flow. The PNM model was subsequently used to compute the macroscopic properties; porosity, absolute permeability, specific surface area, breakthrough capillary pressure, and primary drainage curve. The pore networks were optimized to allow for the simulation results of the macroscopic properties to be in excellent agreement with the experimental measurements. This study demonstrates that non-linear programming and optimization methods provide a promising method for pore network modeling when computed tomography imaging may not be readily available.

  12. [Constructing an ACP Simulation-Situation Communication Training Program for Patients With Chronic Kidney Disease].

    PubMed

    Chen, Jui-O; Lin, Chiu-Chu

    2016-06-01

    The aging population and changing lifestyles have lead to the increased general risk of chronic kidney disease. Taiwan currently has the highest incidence and prevalence of end-stage renal disease (ESRD) of any country or region in the world. Hemodialysis patients must endure comorbidities and face the uncertainties of death. The best way to achieve a good death is for patients to sign advance care planning (ACP). However, the key factors contributing to low ACP signature rates have been the lack of communication skills and related training among medical staffs. This article explores the dilemma of ACP using an example of chronic kidney disease (CKD) and proposes a theory-based approach to develop a theoretical framework for an ACP simulation-situation communication training program that integrates the simulation situation model, PREPARED model, and scaffolding theory. Readers may use this framework to design ACP simulation-situation communication training programs that conform to their own conditions and then test the effectiveness and feasibility of these programs in clinical settings.

  13. The neural guidance receptor Plexin C1 delays melanoma progression

    PubMed Central

    Chen, Y; Soong, J; Mohanty, S; Xu, L; Scott, G

    2013-01-01

    Plexin C1 is a type I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remodeling and adhesion in normal human melanocytes. Melanocytes are pigment-producing cells of the epidermis, precursors for melanoma, and express high levels of Plexin C1, which is lost in melanoma in vitro and in vivo. To determine if Plexin C1 is a tumor suppressor for melanoma, we introduced Plexin C1 into a primary human melanoma cell line, and phenotypes including migration, apoptosis, proliferation and tumor growth in mice were analyzed. Complimentary studies in which Plexin C1 was silenced in human melanocytes were performed. Plexin C1 significantly inhibited migration and proliferation in melanoma, whereas in melanocytes, loss of Plexin C1 increased migration and proliferation. In mouse xenografts, Plexin C1 delayed tumor growth of melanoma at early time points, but tumors eventually escaped the suppressive effects of Plexin C1, due to Plexin C1-dependent activation of the pro-survival protein Akt. R-Ras activation stimulates melanoma migration. Plexin C1 lowered R-Ras activity in melanoma and melanocytes, consistent with inhibitory effects of Plexin C1 on migration of melanocytes and melanoma. To determine if R-Ras is expressed in melanocytic lesions in vivo, staining of tissue microarrays of nevi and melanoma were performed. R-Ras expression was highly limited in melanocytic lesions, being essentially confined to primary melanoma, and almost completely absent in nevi and metastatic melanoma. These data suggest that loss of Plexin C1 in melanoma may promote early steps in melanoma progression through suppression of migration and proliferation, but pro-survival effects of Plexin C1 ultimately abrogate the tumor suppressive effects of Plexin C1. In primary melanoma, loss of Plexin C1 may function in early steps of melanoma progression by releasing inhibition of R-Ras activation, and stimulating migration. PMID:23160370

  14. The neural guidance receptor Plexin C1 delays melanoma progression.

    PubMed

    Chen, Y; Soong, J; Mohanty, S; Xu, L; Scott, G

    2013-10-10

    Plexin C1 is a type I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remodeling and adhesion in normal human melanocytes. Melanocytes are pigment-producing cells of the epidermis, precursors for melanoma, and express high levels of Plexin C1, which is lost in melanoma in vitro and in vivo. To determine if Plexin C1 is a tumor suppressor for melanoma, we introduced Plexin C1 into a primary human melanoma cell line, and phenotypes including migration, apoptosis, proliferation and tumor growth in mice were analyzed. Complimentary studies in which Plexin C1 was silenced in human melanocytes were performed. Plexin C1 significantly inhibited migration and proliferation in melanoma, whereas in melanocytes, loss of Plexin C1 increased migration and proliferation. In mouse xenografts, Plexin C1 delayed tumor growth of melanoma at early time points, but tumors eventually escaped the suppressive effects of Plexin C1, due to Plexin C1-dependent activation of the pro-survival protein Akt. R-Ras activation stimulates melanoma migration. Plexin C1 lowered R-Ras activity in melanoma and melanocytes, consistent with inhibitory effects of Plexin C1 on migration of melanocytes and melanoma. To determine if R-Ras is expressed in melanocytic lesions in vivo, staining of tissue microarrays of nevi and melanoma were performed. R-Ras expression was highly limited in melanocytic lesions, being essentially confined to primary melanoma, and almost completely absent in nevi and metastatic melanoma. These data suggest that loss of Plexin C1 in melanoma may promote early steps in melanoma progression through suppression of migration and proliferation, but pro-survival effects of Plexin C1 ultimately abrogate the tumor suppressive effects of Plexin C1. In primary melanoma, loss of Plexin C1 may function in early steps of melanoma progression by releasing inhibition of R-Ras activation, and stimulating migration.

  15. Constructing a resilience index for the Enhanced Critical Infrastructure Protection Program

    SciTech Connect

    Fisher, R. E.; Bassett, G. W.; Buehring, W. A.; Collins, M. J.; Dickinson, D. C.; Eaton, L. K.; Haffenden, R. A.; Hussar, N. E.; Klett, M. S.; Lawlor, M. A.; Millier, D. J.; Petit, F. D.; Peyton, S. M.; Wallace, K. E.; Whitfield, R. G.; Peerenboom, J P

    2010-10-14

    Following recommendations made in Homeland Security Presidential Directive 7, which established a national policy for the identification and increased protection of critical infrastructure and key resources (CIKR) by Federal departments and agencies, the U.S. Department of Homeland Security (DHS) in 2006 developed the Enhanced Critical Infrastructure Protection (ECIP) program. The ECIP program aimed to provide a closer partnership with state, regional, territorial, local, and tribal authorities in fulfilling the national objective to improve CIKR protection. The program was specifically designed to identify protective measures currently in place in CIKR and to inform facility owners/operators of the benefits of new protective measures. The ECIP program also sought to enhance existing relationships between DHS and owners/operators of CIKR and to build relationships where none existed (DHS 2008; DHS 2009). In 2009, DHS and its protective security advisors (PSAs) began assessing CIKR assets using the ECIP program and ultimately produced individual protective measure and vulnerability values through the protective measure and vulnerability indices (PMI/VI). The PMI/VI assess the protective measures posture of individual facilities at their 'weakest link,' allowing for a detailed analysis of the most vulnerable aspects of the facilities (Schneier 2003), while maintaining the ability to produce an overall protective measures picture. The PMI has six main components (physical security, security management, security force, information sharing, protective measures assessments, and dependencies) and focuses on actions taken by a facility to prevent or deter the occurrence of an incident (Argonne National Laboratory 2009). As CIKR continue to be assessed using the PMI/VI and owners/operators better understand how they can prevent or deter incidents, academic research, practitioner emphasis, and public policy formation have increasingly focused on resilience as a necessary

  16. 26 CFR 1.682(c)-1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Definitions. 1.682(c)-1 Section 1.682(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Miscellaneous § 1.682(c)-1 Definitions. For definitions of the terms “husband” and “wife”...

  17. C1q Deficiency and Neuropsychiatric Systemic Lupus Erythematosus

    PubMed Central

    van Schaarenburg, Rosanne A.; Magro-Checa, César; Bakker, Jaap A.; Teng, Y. K. Onno; Bajema, Ingeborg M.; Huizinga, Tom W.; Steup-Beekman, Gerda M.; Trouw, Leendert A.

    2016-01-01

    C1q deficiency is a rare immunodeficiency, which is strongly associated with the development of systemic lupus erythematosus (SLE). A mutation in one of the C1q genes can either lead to complete deficiency or to low C1q levels with C1q polypeptide in the form of low-molecular weight (LMW) C1q. Patients with C1q deficiency mainly present with cutaneous and renal involvement. Although less frequent, neuropsychiatric (NP) involvement has also been reported in 20% of the C1q-deficient patients. This involvement appears to be absent in other deficiencies of early components of the complement classical pathway (CP) (C1r/C1s, C2, or C4 deficiencies). We describe a new case with C1q deficiency with a homozygous G34R mutation in C1qC-producing LMW-C1q presenting with a severe SLE flare with NP involvement. The serum of this patient contained very low levels of a LMW variant of C1q polypeptides. Cell lysates contained the three chains of C1q, but no intact C1q was detected, consistent with the hypothesis of the existence of a LMW-C1q. Furthermore, we provide a literature overview of NP-SLE in C1q deficiency and hypothesize about the potential role of C1q in the pathogenesis of NP involvement in these patients. The onset of NP-SLE in C1q-deficient individuals is more severe when compared with complement competent NP-SLE patients. An important number of cases present with seizures and the most frequent findings in neuroimaging are changes in basal ganglia and cerebral vasculitis. A defective CP, because of non-functional C1q, does not protect against NP involvement in SLE. The absence of C1q and, subsequently, some of its biological functions may be associated with more severe NP-SLE. PMID:28082982

  18. Nash equilibrium in differential games and the construction of the programmed iteration method

    SciTech Connect

    Averboukh, Yurii V

    2011-05-31

    This work is devoted to the study of nonzero-sum differential games. The set of payoffs in a situation of Nash equilibrium is examined. It is shown that the set of payoffs in a situation of Nash equilibrium coincides with the set of values of consistent functions which are fixed points of the program absorption operator. A condition for functions to be consistent is given in terms of the weak invariance of the graph of the functions under a certain differential inclusion. Bibliography: 18 titles.

  19. Orthogonal polynomial Schauder bases in C[-1,1] with optimal growth of degrees

    SciTech Connect

    Skopina, M A

    2001-04-30

    For each {epsilon}>0 an orthogonal Schauder basis of algebraic polynomials P{sub n} in C[-1,1] is constructed such that the degrees of the polynomials have the estimate n(1+{epsilon}). This growth rate is the lowest possible.

  20. Shuttle Rocket Motor Program: NASA should delay awarding some construction contracts. Report to the Chair, Subcommittee on Government Activities and Transportation, Committee on Government Operations, House of Representatives

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Even though the executive branch has proposed terminating the Advanced Solid Rocket Motor (ASRM) program, NASA is proceeding with all construction activity planned for FY 1992 to avoid schedule slippage if the program is reinstated by Congress. However, NASA could delay some construction activities for at least a few months without affecting the current launch data schedule. For example, NASA could delay Yellow Creek's motor storage and dock projects, Stennis' dock project, and Kennedy's rotation processing and surge facility and dock projects. Starting all construction activities as originally planned could result in unnecessarily incurring additional costs and termination liability if the funding for FY 1993 is not provided. If Congress decides to continue the program, construction could still be completed in time to avoid schedule slippage.

  1. Constructing vulnerabilty and protective measures indices for the enhanced critical infrastructure protection program.

    SciTech Connect

    Fisher, R. E.; Buehring, W. A.; Whitfield, R. G.; Bassett, G. W.; Dickinson, D. C.; Haffenden, R. A.; Klett, M. S.; Lawlor, M. A.; Decision and Information Sciences; LANL

    2009-10-14

    The US Department of Homeland Security (DHS) has directed its Protective Security Advisors (PSAs) to form partnerships with the owners and operators of assets most essential to the Nation's well being - a subclass of critical infrastructure and key resources (CIKR) - and to conduct site visits for these and other high-risk assets as part of the Enhanced Critical Infrastructure Protection (ECIP) Program. During each such visit, the PSA documents information about the facility's current CIKR protection posture and overall security awareness. The primary goals for ECIP site visits (DHS 2009) are to: (1) inform facility owners and operators of the importance of their facilities as an identified high-priority CIKR and the need to be vigilant in light of the ever-present threat of terrorism; (2) identify protective measures currently in place at these facilities, provide comparisons of CIKR protection postures across like assets, and track the implementation of new protective measures; and (3) enhance existing relationships among facility owners and operators; DHS; and various Federal, State, local tribal, and territorial partners. PSAs conduct ECIP visits to assess overall site security; educate facility owners and operators about security; help owners and operators identify gaps and potential improvements; and promote communication and information sharing among facility owners and operators, DHS, State governments, and other security partners. Information collected during ECIP visits is used to develop metrics; conduct sector-by-sector and cross-sector vulnerability comparisons; identify security gaps and trends across CIKR sectors and subsectors; establish sector baseline security survey results; and track progress toward improving CIKR security through activities, programs, outreach, and training (Snyder 2009). The data being collected are used in a framework consistent with the National Infrastructure Protection Plan (NIPP) risk criteria (DHS 2009). The NIPP

  2. Hereditary angioedema with normal C1-INH (HAE type III).

    PubMed

    Riedl, Marc A

    2013-01-01

    Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH), also known as HAE type III, is a familial condition only clinically recognized within the past three decades. Similar to HAE from C1-INH deficiency (HAE types I and II), affected individuals experience unpredictable angioedema episodes of the skin, gastrointestinal tract, and airway. Unique clinical features of HAE with normal C1-INH include the predominance of affected women, frequent exacerbation by estrogen, and a prominence of angioedema that involves the face and oropharynx. The underlying pathophysiology of HAE with normal C1-INH is poorly understood, but indirect evidence points to contact pathway dysregulation with bradykinin-mediated angioedema. Currently, evaluation is complicated by a lack of confirmatory laboratory testing such that clinical criteria must often be used to make the diagnosis of HAE with normal C1-INH. Factor XII mutations have been identified in only a minority of persons affected by HAE with normal C1-INH, limiting the utility of such analysis. To date, no controlled clinical studies have examined the efficacy of therapeutic agents for HAE with normal C1-INH, although published evidence supports frequent clinical benefit with medications shown effective in HAE due to C1-INH deficiency.

  3. Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation

    PubMed Central

    Deng, Liehua; Yang, Hengwen; Zhu, Leqing; Wang, Xiao; Edwards, Michael G.; Richers, Brittany; Leung, Donald Y. M.

    2016-01-01

    The epidermis serves as a critical protective barrier between the internal and external environment of the human body. Its remarkable barrier function is established through the keratinocyte (KC) terminal differentiation program. The transcription factors specifically regulating terminal differentiation remain largely unknown. Using a RNA-sequencing (RNA-seq) profiling approach, we found that forkhead box c 1 (FOXC1) was significantly up-regulated in human normal primary KC during the course of differentiation. This observation was validated in human normal primary KC from several different donors and human skin biopsies. Silencing FOXC1 in human normal primary KC undergoing differentiation led to significant down-regulation of late terminal differentiation genes markers including epidermal differentiation complex genes, keratinization genes, sphingolipid/ceramide metabolic process genes and epidermal specific cell-cell adhesion genes. We further demonstrated that FOXC1 works down-stream of ZNF750 and KLF4, and upstream of GRHL3. Thus, this study defines FOXC1 as a regulator specific for KC terminal differentiation and establishes its potential position in the genetic regulatory network. PMID:27907090

  4. Florida Radon Research Program: Technical support for the development of radon-resistant construction standards. Rept. for Aug-Sep 91

    SciTech Connect

    Sanchez, D.C.; Dixon, R.; Madani, M.

    1991-01-01

    The paper describes the technical direction of the Florida Radon Research Program (FRRP), its current objectives, and accomplishments to date. The 1988 Florida Legislature mandated the development of standards for the construction of radon resistant buildings. A program of research and development was initiated involving the Florida State University System, the Florida Department of Community Affairs, and the U.S. EPA. The FRRP will complete two years of concentrated effort to develop, test, and demonstrate a sound technical basis for radon resistant construction standards.

  5. Missed C1 posterior arch fracture: a case report

    PubMed Central

    Munro, Donald S

    1990-01-01

    A case of a C1 posterior arch fracture following a fall is presented. The need to perform a thorough history and examination, regardless of previous examination findings, is emphasized. This is especially true when there is a history of recent trauma. A brief discussion of the characteristics and management of C1 fractures follows. ImagesFigure 1Figure 2Figure 3

  6. Anti-C1q in systemic lupus erythematosus.

    PubMed

    Stojan, G; Petri, M

    2016-07-01

    C1q is the first component of the classical complement pathway. Both clinically validated in-house ELISA assays as well as commercial ELISA kits are used for detection of anti-C1q antibodies. Anti-C1q autoantibodies can be detected in a wide range of autoimmune diseases and are highly sensitive for hypocomplementemic uticarial vasculitis. In SLE, anti-C1q are strongly associated with proliferative lupus nephritis, and their absence carries a negative predictive value for development of lupus nephritis of close to 100%. Anti-C1q in combination with anti-dsDNA and low complement has the strongest serological association with renal involvement. The anti-C1q titers correlate with global disease activity scores in patients with renal involvement, and higher titers seem to precede renal flares. After the successful treatment of a renal flare, anti-C1q has the tendency to decrease or even become undetectable. The main obstacle to the inclusion of anti-C1q in the classification criteria and clinical management of SLE is the lack of standardized laboratory assays.

  7. 26 CFR 1.661(c)-1 - Limitation on deduction.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Limitation on deduction. 1.661(c)-1 Section 1.661(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Estates and Trusts Which May Accumulate Income Or Which Distribute Corpus §...

  8. 26 CFR 1.662(c)-1 - Different taxable years.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Different taxable years. 1.662(c)-1 Section 1.662(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Estates and Trusts Which May Accumulate Income Or Which Distribute Corpus §...

  9. 26 CFR 1.678(c)-1 - Trusts for support.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Trusts for support. 1.678(c)-1 Section 1.678(c... (CONTINUED) INCOME TAXES Grantors and Others Treated As Substantial Owners § 1.678(c)-1 Trusts for support... cotrustee, to apply the income of the trust to the support or maintenance of a person whom the holder...

  10. 26 CFR 1.1092(c)-1 - Qualified covered calls.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Qualified covered calls. 1.1092(c)-1 Section 1... (CONTINUED) INCOME TAXES Wash Sales of Stock Or Securities § 1.1092(c)-1 Qualified covered calls. (a) In...), however, writing a qualified covered call option and owning the optioned stock is not treated as...

  11. Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement.

    PubMed

    Kapferer-Seebacher, Ines; Pepin, Melanie; Werner, Roland; Aitman, Timothy J; Nordgren, Ann; Stoiber, Heribert; Thielens, Nicole; Gaboriaud, Christine; Amberger, Albert; Schossig, Anna; Gruber, Robert; Giunta, Cecilia; Bamshad, Michael; Björck, Erik; Chen, Christina; Chitayat, David; Dorschner, Michael; Schmitt-Egenolf, Marcus; Hale, Christopher J; Hanna, David; Hennies, Hans Christian; Heiss-Kisielewsky, Irene; Lindstrand, Anna; Lundberg, Pernilla; Mitchell, Anna L; Nickerson, Deborah A; Reinstein, Eyal; Rohrbach, Marianne; Romani, Nikolaus; Schmuth, Matthias; Silver, Rachel; Taylan, Fulya; Vandersteen, Anthony; Vandrovcova, Jana; Weerakkody, Ruwan; Yang, Margaret; Pope, F Michael; Byers, Peter H; Zschocke, Johannes

    2016-11-03

    Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal-dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, joint hypermobility, and mild skin findings. A locus was mapped to an approximately 5.8 Mb region at 12p13.1 but no candidate gene was identified. In an international consortium we recruited 19 independent families comprising 107 individuals with pEDS to identify the locus, characterize the clinical details in those with defined genetic causes, and try to understand the physiological basis of the condition. In 17 of these families, we identified heterozygous missense or in-frame insertion/deletion mutations in C1R (15 families) or C1S (2 families), contiguous genes in the mapped locus that encode subunits C1r and C1s of the first component of the classical complement pathway. These two proteins form a heterotetramer that then combines with six C1q subunits. Pathogenic variants involve the subunit interfaces or inter-domain hinges of C1r and C1s and are associated with intracellular retention and mild endoplasmic reticulum enlargement. Clinical features of affected individuals in these families include rapidly progressing periodontitis with onset in the teens or childhood, a previously unrecognized lack of attached gingiva, pretibial hyperpigmentation, skin and vascular fragility, easy bruising, and variable musculoskeletal symptoms. Our findings open a connection between the inflammatory classical complement pathway and connective tissue homeostasis.

  12. Engagement in a Community of Learners as a Mediating Agent toward the Construction of Technological Pedagogical Content Knowledge (TPACK) in an Online Master's Program

    ERIC Educational Resources Information Center

    Gillow-Wiles, Henry

    2012-01-01

    This study investigates how teachers develop and extend their understanding and knowledge of teaching and learning with digital technologies in a primarily online Master of Science program. The investigation focuses on exploring the relationship between developing an online community of learners and the construction of technological pedagogical…

  13. Department of the Navy FY 1990/FY 1991 Biennial Budget Estimates. Military Construction and Family Housing Program FY 1990. Justification Data Submitted to Congress

    DTIC Science & Technology

    1989-01-01

    TAB "J" ARCHITECTURAL AND ENGINEERING SERVICES AND CONSTRUCTION DESIGN .......................... TAB "K" ACCESS ROADS...Military Construation and Family Housing Program Index of Locations (Dollars in Thousands) . Design State/ Proj. Installation/Location Auth. Approp. As... Design state/ Proj; Installation/Location Auth. Approp. As of Page CANtry .~ftc Prolect Title Request Request Jan 89 No. California Naval Weapons Center

  14. Self-Help Construction of 1-Story Buildings. Appropriate Technologies for Development. Program & Training Journal Manual Series, Number 6.

    ERIC Educational Resources Information Center

    Gallant, Peter

    This manual is designed to assist Peace Corps field workers who have little or no construction experience in helping communities or families to construct one-story buildings. Discussed in a chapter on basic planning and design are site and position; size, shape, and floor plan; and construction materials. The next chapter is a detailed examination…

  15. Modified C1 lateral mass screw insertion using a high entry point to avoid postoperative occipital neuralgia.

    PubMed

    Lee, Sun-Ho; Kim, Eun-Sang; Eoh, Whan

    2013-01-01

    For the past decade, a screw-rod construct has been used commonly to stabilize the atlantoaxial joint, but the insertion of the screw through the C1 lateral mass (LM) can cause several complications. We evaluated whether using a higher screw entry point for C1 lateral mass (LM) fixation than in the standard procedure could prevent screw-induced occipital neuralgia. We enrolled 12 consecutive patients who underwent bilateral C1 LM fixation, with the modified screw insertion point at the junction of the C1 posterior arch and the midpoint of the posterior inferior portion of the C1 LM. We measured postoperative clinical and radiological parameters and recorded intraoperative complications, postoperative neurological deficits and the occurrence of occipital neuralgia. Postoperative plain radiographs were used to check for malpositioning of the screw or failure of the construct. Four patients underwent atlantoaxial stabilization for a transverse ligament injury or a C1 or C2 fracture, six patients for os odontoideum, and two patients for C2 metastasis. No patient experienced vertebral artery injury or cerebrospinal fluid leak, and all had minimal blood loss. No patient suffered significant occipital neuralgia, although one patient developed mild, transient unilateral neuralgia. There was also no radiographic evidence of construct failure. Twenty screws were positioned correctly through the intended entry points, but three screws were placed inferiorly (that is, below the arch), and one screw was inserted too medially. When performing C1-C2 fixation using the standard (Harms) construct, surgeons should be aware of the possible development of occipital neuralgia. A higher entry point may prevent this complication; therefore, we recommend that the screw should be inserted into the arch of C1 if it can be accommodated.

  16. Cbln and C1q family proteins: new transneuronal cytokines.

    PubMed

    Yuzaki, M

    2008-06-01

    The C1q family is characterized by a C-terminal conserved global C1q domain, which is structurally very similar to the tumor necrosis factor homology domain. Although some C1q family members are expressed in the central nervous system, their functions have not been well characterized. Cbln1, a member of the Cbln subfamily of the C1q family, is predominantly expressed in cerebellar granule cells. Interestingly, Cbln1 was recently shown to play two unique roles at excitatory synapses formed between cerebellar granule cells and Purkinje cells: the formation and stabilization of synaptic contact, and the control of functional synaptic plasticity by regulating the postsynaptic endocytosis pathway. Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.

  17. Expression of staphylococcal enterotoxin C1 in Escherichia coli.

    PubMed Central

    Bohach, G A; Schlievert, P M

    1987-01-01

    The structural gene encoding staphylococcal enterotoxin C1 was cloned into Escherichia coli and localized on a 1.5-kilobase HindIII-ClaI DNA fragment by subcloning. The toxin was partially purified from E. coli clones and shown to be immunologically identical to enterotoxin C1 from Staphylococcus aureus. The cloned toxin also had the same molecular weight (26,000) and charge heterogeneity as staphylococcus-derived enterotoxin. Toxins from both sources were equally biologically active. Images PMID:3542834

  18. 26 CFR 1.1402(c)-1 - Trade or business.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Trade or business. 1.1402(c)-1 Section 1.1402(c... (CONTINUED) INCOME TAXES Tax on Self-Employment Income § 1.1402(c)-1 Trade or business. In order for an individual to have net earnings from self-employment, he must carry on a trade or business, either as...

  19. 26 CFR 1.1402(c)-1 - Trade or business.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 12 2012-04-01 2012-04-01 false Trade or business. 1.1402(c)-1 Section 1.1402(c... (CONTINUED) INCOME TAXES (CONTINUED) Tax on Self-Employment Income § 1.1402(c)-1 Trade or business. In order for an individual to have net earnings from self-employment, he must carry on a trade or...

  20. 26 CFR 1.1402(c)-1 - Trade or business.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 12 2013-04-01 2013-04-01 false Trade or business. 1.1402(c)-1 Section 1.1402(c... (CONTINUED) INCOME TAXES (CONTINUED) Tax on Self-Employment Income § 1.1402(c)-1 Trade or business. In order for an individual to have net earnings from self-employment, he must carry on a trade or...

  1. Report to the Board of Regents State University System of Florida. Review of Programs: Architecture, Architectural Technology, Landscape Architecture, Interior Design, Construction and Construction Technology, Building Construction, Urban and Regional Planning.

    ERIC Educational Resources Information Center

    McMinn, William G.

    An evaluation and report was done on the status of programs in architecture and related fields in the Florida State University System as a follow-up to a 1983 evaluation. The evaluation involved self-studies prepared by each program and a series of site visits to each of seven campuses and two centers with programs under review. These institutions…

  2. Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity.

    PubMed

    Colonna, Lucrezia; Parry, Graham C; Panicker, Sandip; Elkon, Keith B

    2016-02-01

    Complement activation contributes to inflammation in many diseases, yet it also supports physiologic apoptotic cells (AC) clearance and its downstream immunosuppressive effects. The roles of individual complement components in AC phagocytosis have been difficult to dissect with artificially depleted sera. Using human in vitro systems and the novel antibody complement C1s inhibitor TNT003, we uncoupled the role of the enzymatic activation of the classical pathway from the opsonizing role of C1q in mediating a) the phagocytosis of early and late AC, and b) the immunosuppressive capacity of early AC. We found that C1s inhibition had a small impact on the physiologic clearance of early AC, leaving their immunosuppressive properties entirely unaffected, while mainly inhibiting the phagocytosis of late apoptotic/secondary necrotic cells. Our data suggest that C1s inhibition may represent a valuable therapeutic strategy to control classical pathway activation without causing significant AC accumulation in diseases without defects in AC phagocytosis.

  3. Participatory Training to Improve Safety and Health in Small Construction Sites in Some Countries in Asia: Development and Application of the WISCON Training Program.

    PubMed

    Kawakami, Tsuyoshi

    2016-08-01

    A participatory training program, Work Improvement in Small Construction Sites, was developed to provide practical support measures to the small construction sector. Managers and workers from selected small sites were interviewed about their occupational safety and health risks. The Work Improvement in Small Construction Sites training program comprised a 45-item action checklist, photos, and illustrations showing local examples and group work methods. Pilot training workshops were carried out with workers and employers in Cambodia, Laos, Mongolia, Thailand, and Vietnam. Participants subsequently planned, and using locally available low-cost materials, implemented their own improvements such as hand-made hand trucks to carry heavy materials, removal of projecting nails from timber materials, and fences to protect roof workers from falling. Local Work Improvement in Small Construction Sites trainers consisting of government officials, workers, employers, and nongovernment organization representatives were then trained to implement the Work Improvement in Small Construction Sites training widely. Keys to success were easy-to-apply training tools aiming at immediate, low-cost improvements, and collaboration with various local people's networks.

  4. What Matters for Excellence in PhD Programs? Latent Constructs of Doctoral Program Quality Used by Early Career Social Scientists

    ERIC Educational Resources Information Center

    Morrison, Emory; Rudd, Elizabeth; Zumeta, William; Nerad, Maresi

    2011-01-01

    This paper unpacks how social science doctorate-holders come to evaluate overall excellence in their PhD training programs based on their domain-specific assessments of aspects of their programs. Latent class analysis reveals that social scientists 6-10 years beyond their PhD evaluate the quality of their doctoral program with one of two…

  5. Using Scratch with Primary School Children: An Evaluation of Games Constructed to Gauge Understanding of Programming Concepts

    ERIC Educational Resources Information Center

    Wilson, Amanda; Hainey, Thomas; Connolly, Thomas M.

    2013-01-01

    Newer approaches such as games-based learning (GBL) and games-based construction are being adopted to motivate and engage students within the Curriculum for Excellence (CfE) in Scotland. GBL and games-based construction suffer from a dearth of empirical evidence supporting their validity as teaching and learning approaches. To address this issue…

  6. Logan Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Steinhoff, Nadene; Jenkins, Ronald

    The Bridgerland Literacy program of Logan Library (Logan, Utah) involved recruitment, retention, public awareness, training, basic literacy, collection development, tutoring, computer assisted, employment oriented, intergenerational/family, and English as a Second Language (ESL) programs. The program served a community of 50,000-100,000 people,…

  7. Project W-320, 241-C-106 sluicing: Construction specification W-320-C1

    SciTech Connect

    Bailey, J.W.

    1998-07-20

    Project W-320, Waste Retrieval Sluicing System (WRSS), specification is for procurement, fabrication and installation of equipment at the C Tank Farm, including Operator Station and some equipment just outside the C Tank Farm fence, necessary to support the sluicing operation. Work consists of furnishing labor, equipment, and materials to provide the means to procure materials and equipment, fabricate items, excavate and place concrete, and install equipment, piping, wiring, and structures in accordance with the Contract Documents. Major work elements include: Excavation for process and fire protection piping, electrical conduit trenches, and foundations for small structures; Placement of concrete cover blocks, foundations, and equipment pads; Procurement and installation of double walled piping, electrical conduit, fire and raw water piping, chilled water piping, and electrical cable; Procurement and installation of above-ground ventilation system piping between the (HVAC) Process building and Tank C-106; Core drill existing concrete; Furnish and installation of electrical distribution equipment; Installation of the concrete foundation, and assembly installation of the two Seismic Shutdown Systems with Environmental Enclosures; Fabrication and installation of in-pit pipe jumpers, including related valves, instruments and wiring; and Installation of a vertical submersible pump, horizontal booster pump, and winch assembly into tank access riser pits.

  8. 26 CFR 1.267(c)-1 - Constructive ownership of stock.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Corporation was owned in equal proportions by A and his partner, AP. Except in the case of distributions in... property made on June 15, 1957, between A and the N Corporation or AP and the N Corporation since each... X, and A's partner, AP, owned 60 percent in value of the outstanding stock of X. The...

  9. 26 CFR 1.267(c)-1 - Constructive ownership of stock.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Corporation was owned in equal proportions by A and his partner, AP. Except in the case of distributions in... property made on June 15, 1957, between A and the N Corporation or AP and the N Corporation since each... X, and A's partner, AP, owned 60 percent in value of the outstanding stock of X. The...

  10. 26 CFR 1.267(c)-1 - Constructive ownership of stock.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Corporation was owned in equal proportions by A and his partner, AP. Except in the case of distributions in... property made on June 15, 1957, between A and the N Corporation or AP and the N Corporation since each... X, and A's partner, AP, owned 60 percent in value of the outstanding stock of X. The...

  11. 26 CFR 1.267(c)-1 - Constructive ownership of stock.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Corporation was owned in equal proportions by A and his partner, AP. Except in the case of distributions in... property made on June 15, 1957, between A and the N Corporation or AP and the N Corporation since each... X, and A's partner, AP, owned 60 percent in value of the outstanding stock of X. The...

  12. 26 CFR 1.267(c)-1 - Constructive ownership of stock.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Corporation was owned in equal proportions by A and his partner, AP. Except in the case of distributions in... property made on June 15, 1957, between A and the N Corporation or AP and the N Corporation since each... X, and A's partner, AP, owned 60 percent in value of the outstanding stock of X. The...

  13. Total synthesis of (-)-CP2-disorazole C1.

    PubMed

    Hopkins, Chad D; Schmitz, John C; Chu, Edward; Wipf, Peter

    2011-08-05

    The total synthesis of a bis-cyclopropane analog of the antimitotic natural product (-)-disorazole C(1) was accomplished in 23 steps and 1.1% overall yield. A vinyl cyclopropane cross-metathesis reaction generated a key (E)-alkene segment of the target molecule. IC(50) determinations of (-)-CP(2)-disorazole C(1) in human colon cancer cell lines indicated low nanomolar cytotoxic properties. Accordingly, this synthetic bioisostere represents the first biologically active disorazole analog not containing a conjugated diene or polyene substructure element.

  14. 26 CFR 1.1092(c)-1 - Qualified covered calls.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 11 2013-04-01 2013-04-01 false Qualified covered calls. 1.1092(c)-1 Section 1... stock price of $14.84. Using the bench marks for an equity option with standardized terms with an adjusted applicable stock price of $14.84, the highest available strike price less than the...

  15. 26 CFR 1.1092(c)-1 - Qualified covered calls.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 11 2014-04-01 2014-04-01 false Qualified covered calls. 1.1092(c)-1 Section 1... stock price of $14.84. Using the bench marks for an equity option with standardized terms with an adjusted applicable stock price of $14.84, the highest available strike price less than the...

  16. Workshops and incentive loans program for construction of solar greenhouses, grain dryers, window boxes and food dryers. Final performance report

    SciTech Connect

    Walker, D.H.

    1982-02-01

    A Solar Loan Fund was established to provide low-interest incentive loans to families desiring to construct their own solar devices, the only stipulations being allowance of reasonable public visitation and monitoring and employment of parish-trained construction teams if labor is to be hired. About 30 vocational agriculture students built window box collector units as part of their classroom experience, trying several designs. Later, 12 to 15 families built window box collectors for their use. A week long Energy Responsibility: Today and Tomorrow workshop was held involving construction projects and mini-seminars. Another workshop was held to construct bread box type solar hot water heaters, and yet another to build solar food dryers. (LEW)

  17. The Social Construction of "Evidence-Based" Drug Prevention Programs: A Reanalysis of Data from the Drug Abuse Resistance Education (DARE) Program

    ERIC Educational Resources Information Center

    Gorman, Dennis M.; Huber, J. Charles, Jr.

    2009-01-01

    This study explores the possibility that any drug prevention program might be considered "evidence-based" given the use of data analysis procedures that optimize the chance of producing statistically significant results by reanalyzing data from a Drug Abuse Resistance Education (DARE) program evaluation. The analysis produced a number of…

  18. A job safety program for construction workers designed to reduce the potential for occupational injury using tool box training sessions and computer-assisted biofeedback stress management techniques.

    PubMed

    Johnson, Kenneth A; Ruppe, Joan

    2002-01-01

    This project was conducted with a multicultural construction company in Hawaii, USA. The job duties performed included drywall and carpentry work. The following objectives were selected for this project: (a) fire prevention training and inspection of first aid equipment; (b) blood-borne pathogen training and risk evaluation; (c) ergonomic and risk evaluation intervention program; (d) electrical safety training and inspection program; (e) slips, trips, and falls safety training; (f) stress assessment and Personal Profile System; (g) safety and health program survey; (h) improving employee relations and morale by emphasizing spirituality; and (i) computer-assisted biofeedback stress management training. Results of the project indicated that observed safety hazards, reported injuries, and levels of perceived stress. were reduced for the majority of the population.

  19. Caudally directed Inferior facetal and transfacetal screws for C1-C2 and C1-2-3 fixation.

    PubMed

    Goel, Atul

    2017-01-13

    An alternative caudally directed C2 inferior facetal screw is described. Such screw insertion can form the axial stabilization point in cases undergoing atlantoaxial lateral mass plate/rod and screw fixation and those undergoing C1-2and C1-2-3 spinal fixation. The C2 screw courses from the medial point of pedicle-laminar junction and travels caudally and laterally towards the C2-3 articulation. Deploying a longer screw that traverses in a transarticular fashion into the facetal mass of C3 vertebra one can perform C1-2-3 stabilization.Sixteen patients underwent C2 inferior facetal or C2-3 transarticular screw in combination with C1 screw for atlantoaxial fixation. Three of these patients with multilevel spinal instability underwent atlantoaxial and C2-3 fixation using the discussed technique. The technical issues, anatomical subtleties and indication for the use of the C2 inferior facetal screws are discussed. With an average follow-up of 9 months, all screws have successfully provided stability that resulted in arthrodesis of the treated spinal segments. Caudally directed C2 inferior facetal screw can enhance the armamentarium of the surgeon, provide an alternative to conventional techniques or a bailout option and add to safety of the procedure of atlantoaxial lateral mass fixation in anatomically challenged situations.

  20. Lowell Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Maravilla, Virginia

    The Lowell Public Library (Indiana) Adult Literacy Program expanded literacy efforts of the library and its volunteer tutors by increasing the program enrollment numbers of the functionally illiterate English-speaking, English as a Second Language (ESL), migrant workers, and Basic Math students; assisted students in achieving their stated goals in…

  1. "You Get to Be Yourself": Visual Arts Programs, Identity Construction and Learners of English as an Additional Language

    ERIC Educational Resources Information Center

    Wielgosz, Meg; Molyneux, Paul

    2015-01-01

    Students learning English as an additional language (EAL) in Australian schools frequently struggle with the cultural and linguistic demands of the classroom while concurrently grappling with issues of identity and belonging. This article reports on an investigation of the role primary school visual arts programs, distinct programs with a…

  2. Entering Industry: A Case Study of Links between a School Vocational Program and the Building and Construction Industry

    ERIC Educational Resources Information Center

    Taylor, Anthea

    2004-01-01

    Few studies have tracked youth transition beyond the immediate post-school period or have looked at the longer-term outcomes of post-school programs. This study reports the findings of a case study investigating links between an industry-specific school vocational education and training (VET) program and subsequent work transitions to the building…

  3. Creating an Anti-Bullying Culture in Secondary Schools: Characteristics to Consider When Constructing Appropriate Anti-Bullying Programs

    ERIC Educational Resources Information Center

    Jones, Joseph R.; Augustine, Sharon Murphy

    2015-01-01

    Bullying in schools is a tremendous challenge that many secondary educators are attempting to address within their school environments. However, educators are often unsure of the attributes of an effective anti-bullying program; thus, they tend to create programs on a "trial and error" basis. This article provides an overview of the…

  4. The effect of excision of the posterior arch of C1 on C1/C2 fusion using transarticular screws.

    PubMed

    Chang, K C; Samartzis, D; Fuego, S M; Dhatt, S S; Wong, Y W; Cheung, W Y; Luk, K D K; Cheung, K M C

    2013-07-01

    Transarticular screw fixation with autograft is an established procedure for the surgical treatment of atlantoaxial instability. Removal of the posterior arch of C1 may affect the rate of fusion. This study assessed the rate of atlantoaxial fusion using transarticular screws with or without removal of the posterior arch of C1. We reviewed 30 consecutive patients who underwent atlantoaxial fusion with a minimum follow-up of two years. In 25 patients (group A) the posterior arch of C1 was not excised (group A) and in five it was (group B). Fusion was assessed on static and dynamic radiographs. In selected patients CT imaging was also used to assess fusion and the position of the screws. There were 15 men and 15 women with a mean age of 51.2 years (23 to 77) and a mean follow-up of 7.7 years (2 to 11.6). Stable union with a solid fusion or a stable fibrous union was achieved in 29 patients (97%). In Group A, 20 patients (80%) achieved a solid fusion, four (16%) a stable fibrous union and one (4%) a nonunion. In Group B, stable union was achieved in all patients, three having a solid fusion and two a stable fibrous union. There was no statistically significant difference between the status of fusion in the two groups. Complications were noted in 12 patients (40%); these were mainly related to the screws, and included malpositioning and breakage. The presence of an intact or removed posterior arch of C1 did not affect the rate of fusion in patients with atlantoaxial instability undergoing C1/C2 fusion using transarticular screws and autograft.

  5. C1 CHEMISTRY FOR THE PRODUCTION OF ULTRA-CLEAN LIQUID TRANSPORTATION FUELS AND HYDROGEN

    SciTech Connect

    Gerald P. Huffman

    2003-03-31

    Faculty and students from five universities--the University of Kentucky, University of Pittsburgh, University of Utah, West Virginia University, and Auburn University--are collaborating in a research program to develop C1 chemistry processes to produce ultra-clean liquid transportation fuels and hydrogen, the zero-emissions transportation fuel of the future. The feedstocks contain one carbon atom per molecular unit. They include synthesis gas (syngas), a mixture of carbon monoxide and hydrogen produced by coal gasification or reforming of natural gas, methane, methanol, carbon dioxide, and carbon monoxide. An important objective is to develop C1 technology for the production of transportation fuel from domestically plentiful resources such as coal, coalbed methane, and natural gas. An Industrial Advisory Board with representatives from Chevron-Texaco, Eastman Chemical, Conoco-Phillips, Energy International, the Department of Defense, and Tier Associates provides guidance on the practicality of the research.

  6. Review of Programs: Architecture; Architectural Technology; Landscape Architecture; Interior Design; Construction and Construction Technology; Building Construction; Urban and Regional Planning. Report to the Board of Regents, State University System of Florida.

    ERIC Educational Resources Information Center

    McMinn, William G.

    This report is an update of a report on the development and status of various programs in architecture and related fields in the State University System of Florida, a report that was submitted to the Board of Regents in May 1983. The objectives of this updated report, like those of the earlier one, are to review the anticipated needs of the…

  7. Encouraging PV Adoption in New Market-Rate ResidentialConstruction: A Critical Review of Program Experiences to Date

    SciTech Connect

    Barbose, Galen; Wiser, Ryan; Bolinger, Mark

    2006-04-24

    In this paper, we review experiences with programs to support the deployment of photovoltaics (PV) in new, market-rate homes, drawing upon interviews with program managers around the country, project data, and publicly-available documentation on program design, impacts, and experiences. We focus on state clean energy funds, which have been established in 14 U.S. states to build markets for clean energy resources, as well as a select number of other state or local organizations whose activities are particularly noteworthy. We describe the types of programs implemented and their impacts to date, and discuss key issues and lessons learned for initiatives aimed at growing the new home market for PV.

  8. Phase equilibria of NdC1 3NaClKCl

    NASA Astrophysics Data System (ADS)

    Hosoya, Yuji; Terai, Takayuki; Tanaka, Satoru; Takahashi, Yoichi

    1997-08-01

    Molten chloride is considered to be applied to a fast-breeder-reactor fuel and a solvent in the pyrochemical reprocessing of spent nuclear fuel. In this work, phase diagrams for molten chloride systems were constructed, using NdCl 3 as an imitative substance in place of UCl 3 or PuCl 3. A compound of 3NdC1 3 · NaCl, which melts incongruently at 540°C to NdCl 3 and liquid and a eutectic at 437°C were found in the NdC1 3NaCl system. In the NdCl 3KCl system, many invariant reactions were observed: the decomposition of NdCl 3 · 2KCl and 2NdCl 3 · KCl at 444 and 474°C, respectively; a eutectic at 489°C; a peritectic at 506°C and a monotectic at 624°C. It is thought that there should be a peritectic compound of 6NdCl 3 · KCl above 474°C. A compound of 2NdC1 3 · NaCl · KCl was considered to exist in the ternary system of NdCl 3NaClKCl, to which attention should be paid in determining the composition of the fuel of the molten-salt fast breeder reactor.

  9. Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system.

    PubMed Central

    Garnier, Gérard; Circolo, Antonella; Xu, Yuanyuan; Volanakis, John E

    2003-01-01

    C1r and C1s are the serine proteases that form the catalytic unit of the C1 complex, the first component of complement. In the present study, we found that the genes encoding murine C1r and C1s are duplicated. One set of these genes, referred to as c1rA and c1sA, are primarily expressed in the liver and are therefore the homologues of the human C1r and C1s genes. The other two genes, termed c1rB and c1sB, are expressed exclusively in male reproductive tissues, specifically the coagulating gland and the prostate. The predicted C1rB and C1sB proteins share 96 and 93% amino acid identity with C1rA and C1sA respectively. Most of the substitutions are clustered in the serine protease domains, suggesting differences in catalytic efficiencies and/or substrate specificities or alternatively adaptation to different physiological environments. The high homology of C1rB and C1sB with C1rA and C1sA in the non-catalytic regions indicates that they are probably capable of assembling the C1 complex. The expression of alternative genes encoding isomorphs of activating components of complement in male reproductive tissues raises the possibility of new mechanisms of complement activation in the male genital tract or of novel functions for complement proteases in reproduction. PMID:12513694

  10. Hereditary angioedema with normal C1 inhibitor: clinical characteristics and treatment response with plasma-derived human C1 inhibitor concentrate (Berinert(®)) in a French cohort.

    PubMed

    Bouillet, Laurence; Boccon-Gibod, Isabelle; Gompel, Anne; Floccard, Bernard; Martin, Ludovic; Blanchard-Delaunay, Claire; Launay, David; Fain, Olivier

    2017-03-01

    Hereditary angioedema (HAE) is a rare genetic disorder characterised by episodes of swelling without urticaria. Berinert® (CSL Behring) is a plasma-derived human C1 inhibitor (C1-INH) concentrate, approved for the treatment of HAE with C1-INH deficiency (C1-INH-HAE), however, it is often used off-label in Europe to treat HAE with normal C1-INH.

  11. Total-contact casting, sandals, and insoles. Construction and applications in a total foot-care program.

    PubMed

    Walker, S C; Helm, P A; Pullium, G

    1995-01-01

    It must be stressed that these tools do not exist in a vacuum and that no single tool is particularly useful unless it is a part of a comprehensive, lifelong foot-care program. A partnership between the health care provider and the patient is essential in making any of these techniques useful. On the positive side, a program incorporating these techniques can be very successful with even the most difficult population. The very successful Parkland Memorial Hospital program provides care for a county hospital population that is often difficult in terms of compliance. Without question, the reasons for incorporating such a program in a public facility are sound. Amputations are avoided; and patients remain or become more functional, thus decreasing hospital cost and patient morbidity and mortality and increasing the patient's potential for contributing to society. Similarly, in private facilities, once the program is established, costs need not run high and considerable amounts can be saved by helping heal and/or prevent the horrendous sequelae of diabetic neuropathies.

  12. Rapid Reactivation of Deep Subsurface Microbes in the Presence of C-1 Compounds

    PubMed Central

    Rajala, Pauliina; Bomberg, Malin; Kietäväinen, Riikka; Kukkonen, Ilmo; Ahonen, Lasse; Nyyssönen, Mari; Itävaara, Merja

    2015-01-01

    Microorganisms in the deep biosphere are believed to conduct little metabolic activity due to low nutrient availability in these environments. However, destructive penetration to long-isolated bedrock environments during construction of underground waste repositories can lead to increased nutrient availability and potentially affect the long-term stability of the repository systems, Here, we studied how microorganisms present in fracture fluid from a depth of 500 m in Outokumpu, Finland, respond to simple carbon compounds (C-1 compounds) in the presence or absence of sulphate as an electron acceptor. C-1 compounds such as methane and methanol are important intermediates in the deep subsurface carbon cycle, and electron acceptors such as sulphate are critical components of oxidation processes. Fracture fluid samples were incubated in vitro with either methane or methanol in the presence or absence of sulphate as an electron acceptor. Metabolic response was measured by staining the microbial cells with fluorescent dyes that indicate metabolic activity and transcriptional response with RT-qPCR. Our results show that deep subsurface microbes exist in dormant states but rapidly reactivate their transcription and respiration systems in the presence of C-1 substrates, particularly methane. Microbial activity was further enhanced by the addition of sulphate as an electron acceptor. Sulphate- and nitrate-reducing microbes were particularly responsive to the addition of C-1 compounds and sulphate. These taxa are common in deep biosphere environments and may be affected by conditions disturbed by bedrock intrusion, as from drilling and excavation for long-term storage of hazardous waste. PMID:27682076

  13. Translating evidence based violence and drug use prevention to obesity prevention: development and construction of the pathways program.

    PubMed

    Sakuma, Kari-Lyn K; Riggs, Nathaniel R; Pentz, Mary Ann

    2012-04-01

    Effective school-based obesity prevention programs are needed to prevent and reduce the growing obesity risk among youth. Utilizing the evidence-rich areas of violence and substance use prevention, translation science may provide an efficient means for developing curricula across multiple health behaviors. This paper introduces Pathways to Health, a school-based obesity prevention program that was developed by translating from evidence-based violence and drug use prevention programs, Promoting Alternative THinking Strategies and the Midwestern Prevention Project STAR (STAR). We illustrate how a hypothesized underlying behavior change mechanism in two domains of risk behavior, violence and substance use, can be applied to obesity prevention. A 4-step translational process is provided and may be relevant for use in developing other curricula to address multiple health risk behaviors. Practical application and decision points are also provided.

  14. Translating evidence based violence and drug use prevention to obesity prevention: development and construction of the Pathways program

    PubMed Central

    Sakuma, Kari-Lyn K.; Riggs, Nathaniel R.; Pentz, Mary Ann

    2012-01-01

    Effective school-based obesity prevention programs are needed to prevent and reduce the growing obesity risk among youth. Utilizing the evidence-rich areas of violence and substance use prevention, translation science may provide an efficient means for developing curricula across multiple health behaviors. This paper introduces Pathways to Health, a school-based obesity prevention program that was developed by translating from evidence-based violence and drug use prevention programs, Promoting Alternative THinking Strategies and the Midwestern Prevention Project STAR (STAR). We illustrate how a hypothesized underlying behavior change mechanism in two domains of risk behavior, violence and substance use, can be applied to obesity prevention. A 4-step translational process is provided and may be relevant for use in developing other curricula to address multiple health risk behaviors. Practical application and decision points are also provided. PMID:21987475

  15. Simplifying the construction of domain-specific automatic programming systems: The NASA automated software development workstation project

    NASA Technical Reports Server (NTRS)

    Allen, Bradley P.; Holtzman, Peter L.

    1987-01-01

    An overview is presented of the Automated Software Development Workstation Project, an effort to explore knowledge-based approaches to increasing software productivity. The project focuses on applying the concept of domain specific automatic programming systems (D-SAPSs) to application domains at NASA's Johnson Space Center. A version of a D-SAPS developed in Phase 1 of the project for the domain of space station momentum management is described. How problems encountered during its implementation led researchers to concentrate on simplifying the process of building and extending such systems is discussed. Researchers propose to do this by attacking three observed bottlenecks in the D-SAPS development process through the increased automation of the acquisition of programming knowledge and the use of an object oriented development methodology at all stages of the program design. How these ideas are being implemented in the Bauhaus, a prototype workstation for D-SAPS development is discussed.

  16. Simplifying the construction of domain-specific automatic programming systems: The NASA automated software development workstation project

    NASA Technical Reports Server (NTRS)

    Allen, Bradley P.; Holtzman, Peter L.

    1988-01-01

    An overview is presented of the Automated Software Development Workstation Project, an effort to explore knowledge-based approaches to increasing software productivity. The project focuses on applying the concept of domain specific automatic programming systems (D-SAPSs) to application domains at NASA's Johnson Space Flight Center. A version of a D-SAPS developed in Phase 1 of the project for the domain of space station momentum management is described. How problems encountered during its implementation led researchers to concentrate on simplifying the process of building and extending such systems is discussed. Researchers propose to do this by attacking three observed bottlenecks in the D-SAPS development process through the increased automation of the acquisition of programming knowledge and the use of an object oriented development methodology at all stages of the program design. How these ideas are being implemented in the Bauhaus, a prototype workstation for D-SAPS development is discussed.

  17. Hartle-Hawking Vacuum for C=1 Tachyon Condensation

    SciTech Connect

    Karczmarek, J.

    2004-05-13

    Quantum vacua are constructed for a time-symmetric cosmology describing closed string tachyon condensation in two-dimensional string theory. Due to the Euclidean periodicity of the solution, and despite its time dependence, we are able to construct thermal states at discrete values of the temperature. The asymptotic thermal Green functions and stress energy tensor are computed and found to have an intriguing resemblance to those in the Hartle-Hawking vacuum of a black hole.

  18. Reduction of CO2 to C1 products and fuel

    USGS Publications Warehouse

    Mill, T.; Ross, D.

    2002-01-01

    Photochemical semiconductor processes readily reduced CO2 to a broad range of C1 products. However the intrinsic and solar efficiencies for the processes were low. Improved quantum efficiencies could be realized utilizing quantum-sized particles, but at the expense of using less of the visible solar spectrum. Conversely, semiconductors with small bandgaps used more of the visible solar spectrum at the expense of quantum efficiency. Thermal reduction of CO2 with Fe(II) was thermodynamically favored for forming many kinds of organic compounds and occurred readily with olivine and other Fe(II) minerals above 200??C to form higher alkanes and alkenes. No added hydrogen was required.

  19. C1-Cx revisited: intramolecular synergism in a cellulase.

    PubMed Central

    Din, N; Damude, H G; Gilkes, N R; Miller, R C; Warren, R A; Kilburn, D G

    1994-01-01

    Endoglucanase A (CenA) from the bacterium Cellulomonas fimi is composed of a catalytic domain and a nonhydrolytic cellulose-binding domain that can function independently. The individual domains interact synergistically in the disruption and hydrolysis of cellulose fibers. This intramolecular synergism is distinct from the well-known intermolecular synergism between individual cellulases. The catalytic domain corresponds to the hydrolytic Cx system and the cellulose-binding domain corresponds to the nonhydrolytic C1 system postulated by Reese et al. [Reese, E. T., Sui, R. G. H. & Levinson, H. S. (1950) J. Bacteriol. 59, 485-497] to be required for the hydrolysis of cellulose. PMID:7972069

  20. Posterior arch C-1 screw technique: a cadaveric comparison study.

    PubMed

    Moisi, Marc; Fisahn, Christian; Tkachenko, Lara; Jeyamohan, Shiveindra; Reintjes, Stephen; Grunert, Peter; Norvell, Daniel C; Tubbs, R Shane; Page, Jeni; Newell, David W; Nora, Peter; Oskouian, Rod J; Chapman, Jens

    2017-03-17

    OBJECTIVE Posterior atlantoaxial stabilization and fusion using C-1 lateral mass screw fixation has become commonly used in the treatment of instability and for reconstructive indications since its introduction by Goel and Laheri in 1994 and modification by Harms in 2001. Placement of such lateral mass screws can be challenging because of the proximity to the spinal cord, vertebral artery, an extensive venous plexus, and the C-2 nerve root, which overlies the designated starting point on the posterior center of the lateral mass. An alternative posterior access point starting on the posterior arch of C-1 could provide a C-2 nerve root-sparing starting point for screw placement, with the potential benefit of greater directional control and simpler trajectory. The authors present a cadaveric study comparing an alternative strategy (i.e., a C-1 screw with a posterior arch starting point) to the conventional strategy (i.e., using the lower lateral mass entry site), specifically assessing the safety of screw placement to preserve the C-2 nerve root. METHODS Five US-trained spine fellows instrumented 17 fresh human cadaveric heads using the Goel/Harms C-1 lateral mass (GHLM) technique on the left and the posterior arch lateral mass (PALM) technique on the right, under fluoroscopic guidance. After screw placement, a CT scan was obtained on each specimen to assess for radiographic screw placement accuracy. Four faculty spine surgeons, blinded to the surgeon who instrumented the cadaver, independently graded the quality of screw placement using a modified Upendra classification. RESULTS Of the 17 specimens, the C-2 nerve root was anatomically impinged in 13 (76.5%) of the specimens. The GHLM technique was graded Type 1 or 2, which is considered "acceptable," in 12 specimens (70.6%), and graded Type 3 or 4 ("unacceptable") in 5 specimens (29.4%). In contrast, the PALM technique had 17 (100%) of 17 graded Type 1 or 2 (p = 0.015). There were no vertebral artery injuries found

  1. Pottsville Free Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Smink, Nancy J.; Bridal, Wendy

    This final performance report provides project outcome information and data to the U.S. Department of Education for the federally-funded Library Literacy Program. The Pottsville Free Public Library conducted a project that involved recruitment, retention, public awareness, training, basic literacy, collection development, tutoring, other…

  2. Groton Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Benkert, Alan G.; Glover, Jane

    This final performance report for Groton Public Library's Project LIFT (Libraries Involve Families Today), an outreach program designed to promote literacy among low-income families, begins with a section that provides quantitative data. The role of the library in the project is then described; participating organizations and sites used are…

  3. Teacher Candidates Learning from English Learners: Constructing Concepts of Language and Culture in Tuesday's Tutors After-School Program

    ERIC Educational Resources Information Center

    Fitts, Shanan; Gross, Lisa A.

    2012-01-01

    In teacher preparation programs across the United States, early field experiences are considered to be an effective method of providing teacher candidates with opportunities to observe and interact with children (National Council for Accreditation for Teacher Education (NCATE, 2010). These practicum arrangements assist candidates in developing…

  4. Elizabeth Jones Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Smith, Valinda C.

    This final performance report for the Elizabeth Jones Library literacy project begins with a section that provides quantitative data. The next section compares actual accomplishments to the following project goals and related objectives for fiscal year 1992: (1) to provide a versatile workplace literacy program useful to any business in the…

  5. West Georgia Regional Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Willis, Roni L.

    This final performance report provides project outcome information and data to the U.S. Department of Education for the federally-funded Library Literacy Program. The West Georgia Regional Library conducted a project from October 1992 until September 1993 that involved collection development and providing tutoring services to adult learners in a…

  6. Summers County Public Library, Final Performance Report for Library Services and Construction Act (LSCA) Title VI, Library Literacy Program.

    ERIC Educational Resources Information Center

    Ziegler, Myra; Garten, Thelma

    This Final Performance Report provides project outcome information and data to the U.S. Department of Education for the federally-funded Library Literacy Program. The Literate Adults Mean Prosperity (LAMP) project of the Summers County Public Library (Hinton, West Virginia), provided recruitment, retention, training, rural oriented, basic…

  7. Measurement of cognitive performance in computer programming concept acquisition: interactive effects of visual metaphors and the cognitive style construct.

    PubMed

    McKay, E

    2000-01-01

    An innovative research program was devised to investigate the interactive effect of instructional strategies enhanced with text-plus-textual metaphors or text-plus-graphical metaphors, and cognitive style on the acquisition of programming concepts. The Cognitive Styles Analysis (CSA) program (Riding,1991) was used to establish the participants' cognitive style. The QUEST Interactive Test Analysis System (Adams and Khoo,1996) provided the cognitive performance measuring tool, which ensured an absence of error measurement in the programming knowledge testing instruments. Therefore, reliability of the instrumentation was assured through the calibration techniques utilized by the QUEST estimate; providing predictability of the research design. A means analysis of the QUEST data, using the Cohen (1977) approach to size effect and statistical power further quantified the significance of the findings. The experimental methodology adopted for this research links the disciplines of instructional science, cognitive psychology, and objective measurement to provide reliable mechanisms for beneficial use in the evaluation of cognitive performance by the education, training and development sectors. Furthermore, the research outcomes will be of interest to educators, cognitive psychologists, communications engineers, and computer scientists specializing in computer-human interactions.

  8. Constructing Knowledge with an Agent-Based Instructional Program: A Comparison of Cooperative and Individual Meaning Making

    ERIC Educational Resources Information Center

    Moreno, Roxana

    2009-01-01

    Participants in the present study were 87 college students who learned about botany using an agent-based instructional program with three different learning approaches: individual, jigsaw, or cooperative learning. Results showed no differences among learning approaches on retention. Students in jigsaw groups reported higher cognitive load during…

  9. Translating Evidence Based Violence and Drug Use Prevention to Obesity Prevention: Development and Construction of the Pathways Program

    ERIC Educational Resources Information Center

    Sakuma, Kari-Lyn K.; Riggs, Nathaniel R.; Pentz, Mary Ann

    2012-01-01

    Effective school-based obesity prevention programs are needed to prevent and reduce the growing obesity risk among youth. Utilizing the evidence-rich areas of violence and substance use prevention, translation science may provide an efficient means for developing curricula across multiple health behaviors. This paper introduces Pathways to Health,…

  10. Measuring the Effectiveness of Transfer of Learning Constructs and Intent to Transfer in a Simulation-Based Leadership Training Program

    ERIC Educational Resources Information Center

    Hix, Joanne W.

    2013-01-01

    The purpose of business training programs is to improve performance, which improved performance changes leadership behaviors based on the knowledge, skills, and abilities (KSAs) learned in training. One of the most common criticisms of leadership training is the tendency to focus on teaching theory but not on applying theory into practice, that…

  11. C1 inhibitor deficiency: 2014 United Kingdom consensus document.

    PubMed

    Longhurst, H J; Tarzi, M D; Ashworth, F; Bethune, C; Cale, C; Dempster, J; Gompels, M; Jolles, S; Seneviratne, S; Symons, C; Price, A; Edgar, D

    2015-06-01

    C1 inhibitor deficiency is a rare disorder manifesting with recurrent attacks of disabling and potentially life-threatening angioedema. Here we present an updated 2014 United Kingdom consensus document for the management of C1 inhibitor-deficient patients, representing a joint venture between the United Kingdom Primary Immunodeficiency Network and Hereditary Angioedema UK. To develop the consensus, we assembled a multi-disciplinary steering group of clinicians, nurses and a patient representative. This steering group first met in 2012, developing a total of 48 recommendations across 11 themes. The statements were distributed to relevant clinicians and a representative group of patients to be scored for agreement on a Likert scale. All 48 statements achieved a high degree of consensus, indicating strong alignment of opinion. The recommendations have evolved significantly since the 2005 document, with particularly notable developments including an improved evidence base to guide dosing and indications for acute treatment, greater emphasis on home therapy for acute attacks and a strong focus on service organization.

  12. C1 inhibitor deficiency: 2014 United Kingdom consensus document

    PubMed Central

    Longhurst, H J; Tarzi, M D; Ashworth, F; Bethune, C; Cale, C; Dempster, J; Gompels, M; Jolles, S; Seneviratne, S; Symons, C; Price, A; Edgar, D

    2015-01-01

    C1 inhibitor deficiency is a rare disorder manifesting with recurrent attacks of disabling and potentially life-threatening angioedema. Here we present an updated 2014 United Kingdom consensus document for the management of C1 inhibitor-deficient patients, representing a joint venture between the United Kingdom Primary Immunodeficiency Network and Hereditary Angioedema UK. To develop the consensus, we assembled a multi-disciplinary steering group of clinicians, nurses and a patient representative. This steering group first met in 2012, developing a total of 48 recommendations across 11 themes. The statements were distributed to relevant clinicians and a representative group of patients to be scored for agreement on a Likert scale. All 48 statements achieved a high degree of consensus, indicating strong alignment of opinion. The recommendations have evolved significantly since the 2005 document, with particularly notable developments including an improved evidence base to guide dosing and indications for acute treatment, greater emphasis on home therapy for acute attacks and a strong focus on service organization. PMID:25605519

  13. An Exploratory Study to Investigate the Aspects of the Construction and Use of Instruments Encompassing the Evaluative Strategies of Context, Input, Process, and Product of In-Service Programs.

    ERIC Educational Resources Information Center

    Rice, Ernest Thomas

    This paper describes the construction and use of a set of evaluative instruments to aid in the planning of in-service programs. The four instruments constructed used Stufflebeam's four evaluative strategies: context, input, process, and product. They were designed to provide rating which could be compared in regard to personnel group and local…

  14. Building Technology: Under Construction.

    ERIC Educational Resources Information Center

    Weltman, June

    2002-01-01

    Discusses a number of community college-based training concepts for the construction trades. These programs integrate classroom, lab, and work experience, and some offer credits toward applied sciences or other degrees. Describes the Florida Construction Institute at Florida Community College, Jacksonville, and other construction education…

  15. Analysis of the Interaction between Globular Head Modules of Human C1q and Its Candidate Receptor gC1qR

    PubMed Central

    Pednekar, Lina; Pathan, Ansar A.; Paudyal, Basudev; Tsolaki, Anthony G.; Kaur, Anuvinder; Abozaid, Suhair M.; Kouser, Lubna; Khan, Haseeb A.; Peerschke, Ellinor I.; Shamji, Mohamed H.; Stenbeck, Gudrun; Ghebrehiwet, Berhane; Kishore, Uday

    2016-01-01

    The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight into the pleiotropic functions of gC1qR, this study was undertaken to identify the gC1qR-binding site on the gC1q domain, using the recombinant ghA, ghB, and ghC modules and their substitution mutants. Our results show that ghA, ghB, and ghC modules can interact with gC1qR independently, thus reinforcing the notion of modularity within the gC1q domain of human C1q. Mutational analysis revealed that while Arg162 in the ghA module is central to interaction between gC1qR and C1q, a single amino acid substitution (arginine to glutamate) in residue 114 of the ghB module resulted in enhanced binding. Expression of gC1qR and C1q in adherent monocytes with or without pro-inflammatory stimuli was also analyzed by qPCR; it showed an autocrine/paracrine basis of C1q and gC1qR interaction. Microscopic studies revealed that C1q and gC1qR are colocalized on PBMCs. Cell proliferation assays indicated that ghA, ghB, and ghC modules were able to attenuate phytohemagglutinin-stimulated proliferation of PBMCs. Addition of gC1qR had an additive effect on the anti-proliferative effect of globular head modules. In summary, our results identify residues involved in C1q-gC1qR interaction and explain, to a certain level, their involvement on the immune cell surface, which is relevant for C1q-induced functions including inflammation, infection, and immunity. PMID:28018340

  16. Analysis of the Interaction between Globular Head Modules of Human C1q and Its Candidate Receptor gC1qR.

    PubMed

    Pednekar, Lina; Pathan, Ansar A; Paudyal, Basudev; Tsolaki, Anthony G; Kaur, Anuvinder; Abozaid, Suhair M; Kouser, Lubna; Khan, Haseeb A; Peerschke, Ellinor I; Shamji, Mohamed H; Stenbeck, Gudrun; Ghebrehiwet, Berhane; Kishore, Uday

    2016-01-01

    The heterotrimeric globular head (gC1q) domain of human C1q is made up of the C-terminal ends of the three individual chains, ghA, ghB, and ghC. A candidate receptor for the gC1q domain is a multi-functional pattern recognition protein, gC1qR. Since understanding of gC1qR and gC1q interaction could provide an insight into the pleiotropic functions of gC1qR, this study was undertaken to identify the gC1qR-binding site on the gC1q domain, using the recombinant ghA, ghB, and ghC modules and their substitution mutants. Our results show that ghA, ghB, and ghC modules can interact with gC1qR independently, thus reinforcing the notion of modularity within the gC1q domain of human C1q. Mutational analysis revealed that while Arg162 in the ghA module is central to interaction between gC1qR and C1q, a single amino acid substitution (arginine to glutamate) in residue 114 of the ghB module resulted in enhanced binding. Expression of gC1qR and C1q in adherent monocytes with or without pro-inflammatory stimuli was also analyzed by qPCR; it showed an autocrine/paracrine basis of C1q and gC1qR interaction. Microscopic studies revealed that C1q and gC1qR are colocalized on PBMCs. Cell proliferation assays indicated that ghA, ghB, and ghC modules were able to attenuate phytohemagglutinin-stimulated proliferation of PBMCs. Addition of gC1qR had an additive effect on the anti-proliferative effect of globular head modules. In summary, our results identify residues involved in C1q-gC1qR interaction and explain, to a certain level, their involvement on the immune cell surface, which is relevant for C1q-induced functions including inflammation, infection, and immunity.

  17. Children "At Risk": Constructions of Childhood in the 21st Century Community Learning Centers Federal After-School Program

    ERIC Educational Resources Information Center

    Chappell, Sharon Verner

    2006-01-01

    In 2001, the U.S. government allocated $4.5 billion to after-school programs through the 21st Century Community Learning Centers (21st CCLC) grant directed at high-poverty, low-performing schools. Since 2003, 6,800 rural and urban public schools have been served around the country, at county, city, and district levels as well as some organizations…

  18. Interaction of HmC1q with leech microglial cells: involvement of C1qBP-related molecule in the induction of cell chemotaxis

    PubMed Central

    2012-01-01

    Background In invertebrates, the medicinal leech is considered to be an interesting and appropriate model to study neuroimmune mechanisms. Indeed, this non-vertebrate animal can restore normal function of its central nervous system (CNS) after injury. Microglia accumulation at the damage site has been shown to be required for axon sprouting and for efficient regeneration. We characterized HmC1q as a novel chemotactic factor for leech microglial cell recruitment. In mammals, a C1q-binding protein (C1qBP alias gC1qR), which interacts with the globular head of C1q, has been reported to participate in C1q-mediated chemotaxis of blood immune cells. In this study, we evaluated the chemotactic activities of a recombinant form of HmC1q and its interaction with a newly characterized leech C1qBP that acts as its potential ligand. Methods Recombinant HmC1q (rHmC1q) was produced in the yeast Pichia pastoris. Chemotaxis assays were performed to investigate rHmC1q-dependent microglia migration. The involvement of a C1qBP-related molecule in this chemotaxis mechanism was assessed by flow cytometry and with affinity purification experiments. The cellular localization of C1qBP mRNA and protein in leech was investigated using immunohistochemistry and in situ hybridization techniques. Results rHmC1q-stimulated microglia migrate in a dose-dependent manner. This rHmC1q-induced chemotaxis was reduced when cells were preincubated with either anti-HmC1q or anti-human C1qBP antibodies. A C1qBP-related molecule was characterized in leech microglia. Conclusions A previous study showed that recruitment of microglia is observed after HmC1q release at the cut end of axons. Here, we demonstrate that rHmC1q-dependent chemotaxis might be driven via a HmC1q-binding protein located on the microglial cell surface. Taken together, these results highlight the importance of the interaction between C1q and C1qBP in microglial activation leading to nerve repair in the medicinal leech. PMID:22356764

  19. Overview of GCOM-C1/SGLI science

    NASA Astrophysics Data System (ADS)

    Honda, Yoshiaki; Kajiwara, Koji; Sharma, Ram; Ono, Akiko; Imaoka, Kenji; Murakami, Hiroshi; Hori, Masahiro; Ono, Yusaku; Rostand, Dim

    2012-11-01

    For monitoring of global environmental change, the Japan Aerospace Exploration Agency (JAXA) has made a new plan of Global Change Observation Mission (GCOM). SGLI (Second Generation GLI) onboard GCOM-C (Climate) satellite, which is one of this mission, provides an optical sensor from Near-UV to TIR. Characteristic specifications of SGLI are as follows; 1) 250m resolutions over land and area along the shore, 2) Three directional polarization observation (red and NIR), and 3) 500m resolutions temperature over land and area along shore. These characteristics are useful in many fields of social benefits. In addition, 51 products will be made by mainly 35 principal investigators. We introduce the overview of GCOM-C1/SGLI science.

  20. Plasma enhanced C1 chemistry for green technology

    NASA Astrophysics Data System (ADS)

    Nozaki, Tomohiro

    2013-09-01

    Plasma catalysis is one of the innovative next generation green technologies that meet the needs for energy and materials conservation as well as environmental protection. Non-thermal plasma uniquely generates reactive species independently of reaction temperature, and these species are used to initiate chemical reactions at unexpectedly lower temperatures than normal thermochemical reactions. Non-thermal plasma thus broadens the operation window of existing chemical conversion processes, and ultimately allows modification of the process parameters to minimize energy and material consumption. We have been specifically focusing on dielectric barrier discharge (DBD) as one of the viable non-thermal plasma sources for practical fuel reforming. In the presentation, room temperature one-step conversion of methane to methanol and hydrogen using a miniaturized DBD reactor (microplasma reactor) is highlighted. The practical impact of plasma technology on existing C1-chemistry is introduced, and then unique characteristics of plasma fuel reforming such as non-equilibrium product distribution is discussed.

  1. C1,1 regularity for degenerate elliptic obstacle problems

    NASA Astrophysics Data System (ADS)

    Daskalopoulos, Panagiota; Feehan, Paul M. N.

    2016-03-01

    The Heston stochastic volatility process is a degenerate diffusion process where the degeneracy in the diffusion coefficient is proportional to the square root of the distance to the boundary of the half-plane. The generator of this process with killing, called the elliptic Heston operator, is a second-order, degenerate-elliptic partial differential operator, where the degeneracy in the operator symbol is proportional to the distance to the boundary of the half-plane. In mathematical finance, solutions to the obstacle problem for the elliptic Heston operator correspond to value functions for perpetual American-style options on the underlying asset. With the aid of weighted Sobolev spaces and weighted Hölder spaces, we establish the optimal C 1 , 1 regularity (up to the boundary of the half-plane) for solutions to obstacle problems for the elliptic Heston operator when the obstacle functions are sufficiently smooth.

  2. A Selection of Recent Advances in C1 Chemistry.

    PubMed

    Mesters, Carl

    2016-06-07

    This review presents a selection of recent publications related to the chemistry and catalysis of C1 molecules, including methane, methanol, carbon monoxide, and carbon dioxide. These molecules play an important role in the current supply of energy and chemicals and will likely become even more relevant because of the need to decarbonize fuels (shift from coal to natural gas) in line with CO2 capture and use to mitigate global warming, as well as a gradual shift on the supply side from crude oil to natural gas. This review includes both recent industrial developments, such as the huge increase in methanol-to-olefins-capacity build in China and the demonstration of oxidative coupling of methane, and scientific developments in these chemistries facilitated by improved capabilities in, for example, analytical tools and computational modeling.

  3. 75 FR 53861 - Airworthiness Directives; Robert E. Rust, Jr. Model DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ...-025-AD; Amendment 39-16426; AD 2010-18-01] RIN 2120-AA64 Airworthiness Directives; Robert E. Rust, Jr... adopting a new airworthiness directive (AD) for all Robert E. Rust, Jr. Models DeHavilland DH.C1 Chipmunk... Robert E. Rust, Jr. Models DeHavilland DH.C1 Chipmunk 21, DH.C1 Chipmunk 22, and DH.C1 Chipmunk...

  4. High resolution spectroscopy of comet C/2002 C1 Ikeya-Zhang with SARG at TNG

    NASA Astrophysics Data System (ADS)

    Capria, M. T.; Cremonese, G.; Boattini, A.; de Sanctis, M. C.; D'Abramo, G.; Buzzoni, A.

    2002-11-01

    A program of high resolution spectroscopy of comets is being conducted at TNG in Canary Islands using the echelle spectrograph SARG. The aim of the program is to catalogue known and unknown emission lines, compare them with the lines already listed in existing catalogues and possibly identify unknown lines. In the visible range of the spectrum emission lines of daughter molecules and ions can be found, and many of them are still unidentified. The comet C/2002 C1 Ikeya-Zhang was observed with SARG during the night 19-20 of April and spectra with two different setups were taken. In the first case a narrow band filter was used to isolate the sodium emissions with a long slit and R = 43000. The data show very interesting cometary sodium emissions in the coma. The second setup used a short slit covering the spectral range of 4620-7920 Å with R = 57000.

  5. C1 CHEMISTRY FOR THE PRODUCTION OF ULTRA-CLEAN LIQUID TRANSPORTATION FUELS AND HYDROGEN

    SciTech Connect

    Gerald P. Huffman

    2004-03-31

    Faculty and students from five universities--the University of Kentucky, University of Pittsburgh, University of Utah, West Virginia University, and Auburn University--are collaborating in a research program to develop C1 chemistry processes to produce ultra-clean liquid transportation fuels and hydrogen, the zero-emissions transportation fuel of the future. The feedstocks contain one carbon atom per molecular unit. They include synthesis gas (syngas), a mixture of carbon monoxide and hydrogen produced by coal gasification or reforming of natural gas, methane, methanol, carbon dioxide, and carbon monoxide. An important objective is to develop C1 technology for the production of liquid transportation fuel and hydrogen from domestically plentiful resources such as coal, coalbed methane, and natural gas. An Industrial Advisory Board with representatives from Chevron-Texaco, Eastman Chemical, Conoco-Phillips, the Air Force Research Laboratory, the U.S. Army National Automotive Center (Tank & Automotive Command--TACOM), and Tier Associates provides guidance on the practicality of the research. The current report presents results obtained in this research program during the six months of the subject contract from October 1, 2002 through March 31, 2003. The results are presented in thirteen detailed reports on research projects headed by various faculty members at each of the five CFFS Universities. Additionally, an Executive Summary has been prepared that summarizes the principal results of all of these projects during the six-month reporting period.

  6. C1 Chemistry for the Production of Ultra-Clean Liquid Transportation Fuels and Hydrogen

    SciTech Connect

    Gerald P. Huffman

    2003-03-31

    Faculty and students from five universities--the University of Kentucky, University of Pittsburgh, University of Utah, West Virginia University, and Auburn University--are collaborating in a research program to develop C1 chemistry processes to produce ultra-clean liquid transportation fuels and hydrogen, the zero-emissions transportation fuel of the future. The feedstocks contain one carbon atom per molecular unit. They include synthesis gas (syngas), a mixture of carbon monoxide and hydrogen produced by coal gasification or reforming of natural gas, methane, methanol, carbon dioxide, and carbon monoxide. An important objective is to develop C1 technology for the production of transportation fuel from domestically plentiful resources such as coal, coalbed methane, and natural gas. An Industrial Advisory Board with representatives from Chevron-Texaco, Eastman Chemical, Conoco-Phillips, Energy International, the Department of Defense, and Tier Associates provides guidance on the practicality of the research. The current report presents results obtained in this research program during the first six months of the subject contract (DE-FC26-02NT-4159), from October 1, 2002 through March 31, 2003.

  7. C1 Chemistry for the Production of Ultra-Clean Liquid Transportation Fuels and Hydrogen

    SciTech Connect

    Gerald P. Huffman

    2005-03-31

    Faculty and students from five universities--the University of Kentucky, University of Pittsburgh, University of Utah, West Virginia University, and Auburn University--are collaborating in a research program to develop C1 chemistry processes to produce ultra-clean liquid transportation fuels and hydrogen, the zero-emissions transportation fuel of the future. The feedstocks contain one carbon atom per molecular unit. They include synthesis gas (syngas), a mixture of carbon monoxide and hydrogen produced by coal gasification or reforming of natural gas, methane, methanol, carbon dioxide, and carbon monoxide. An important objective is to develop C1 technology for the production of liquid transportation fuel and hydrogen from domestically plentiful resources such as coal, coalbed methane, and natural gas. An Industrial Advisory Board with representatives from Chevron-Texaco, Eastman Chemical, Conoco-Phillips, the Air Force Research Laboratory, the U.S. Army National Automotive Center (Tank & Automotive Command--TACOM), and Tier Associates provides guidance on the practicality of the research. The current report presents results obtained in this research program during the six months of the subject contract from October 1, 2002 through March 31, 2003. The results are presented in thirteen detailed reports on research projects headed by various faculty members at each of the five CFFS Universities. Additionally, an Executive Summary has been prepared that summarizes the principal results of all of these projects during the six-month reporting period.

  8. Longevity, aging, and caloric restriction: Clive Maine McCay and the construction of a multidisciplinary research program.

    PubMed

    Park, Hyung Wook

    2010-01-01

    Since the 1930s scientists from fields such as biochemistry, pathology, immunology, genetics, neuroscience, and nutrition have studied the relation of dietary caloric intake to longevity and aging. This paper discusses how Clive Maine McCay, a professor of animal husbandry at Cornell University, began his investigation of the topic and promoted it as a productive research program in the multidisciplinary science of gerontology. Initially, McCay observed the effect of reduced-calorie diets on life span and senescence while pursuing his nutrition research in the context of animal husbandry and agriculture. But when he received funding from the Rockefeller Foundation and started to participate in the establishment of gerontology during the 1930s, the scope of his research was considerably expanded beyond his original disciplinary domain. It became a multidisciplinary research program that attracted scholars from a variety of scientific and medical disciplines. This paper argues that through this expansion McCay's research created a means of maintaining cooperation among the diverse and heterogeneous academic fields constituting gerontology.

  9. Catalytic routes to fuels from C1 and oxygenate molecules.

    PubMed

    Wang, Shuai; Agirrezabal-Telleria, Iker; Bhan, Aditya; Simonetti, Dante; Takanabe, Kazuhiro; Iglesia, Enrique

    2017-03-16

    This account illustrates concepts in chemical kinetics underpinned by the formalism of transition state theory using catalytic processes that enable the synthesis of molecules suitable as fuels from C1 and oxygenate reactants. Such feedstocks provide an essential bridge towards a carbon-free energy future, but their volatility and low energy density require the formation of new C-C bonds and the removal of oxygen. These transformations are described here through recent advances in our understanding of the mechanisms and site requirements in catalysis by surfaces, with emphasis on enabling concepts that tackle ubiquitous reactivity and selectivity challenges. The hurdles in forming the first C-C bond from C1 molecules are illustrated by the oxidative coupling of methane, in which surface O-atoms form OH radicals from O2 and H2O molecules. These gaseous OH species act as strong H-abstractors and activate C-H bonds with earlier transition states than oxide surfaces, thus rendering activation rates less sensitive to the weaker C-H bonds in larger alkane products than in CH4 reactants. Anhydrous carbonylation of dimethyl ether forms a single C-C bond on protons residing within inorganic voids that preferentially stabilize the kinetically-relevant transition state through van der Waals interactions that compensate for the weak CO nucleophile. Similar solvation effects, but by intrapore liquids instead of inorganic hosts, also become evident as alkenes condense within MCM-41 channels containing isolated Ni(2+) active sites during dimerization reactions. Intrapore liquids preferentially stabilize transition states for C-C bond formation and product desorption, leading to unprecedented reactivity and site stability at sub-ambient temperatures and to 1-alkene dimer selectivities previously achieved only on organometallic systems with co-catalysts or activators. C1 homologation selectively forms C4 and C7 chains with a specific backbone (isobutane, triptane) on solid acids

  10. [The coverage of science in television news programs in Brazil and Colombia: a comparative study of media constructs].

    PubMed

    Ramalho, Marina; Arboleda, Tania; Hermelin, Daniel; Reznik, Gabriela; Massarani, Luisa

    2016-09-12

    This study analyzes and compares the science and technology coverage in Brazil's main television news program (Jornal Nacional) and its Colombian counterpart (Noticias Caracol). Using content analysis, we investigated a corpus of news stories broadcast from April 2009 to March 2010. We found that Jornal Nacional presented over twice as many reports on science and technology as Noticias Caracol, and that its levels of reporting remained fairly stable throughout the year. The Brazilian reports were also longer, were featured more prominently, and used more visual resources. Even so, some similarities were found: news about health and medicine was most frequent; the reports focused primarily on announcing new research; scientists were the main sources cited; and national research was prioritized.

  11. Preliminary design data package, appendices C1 and C2

    NASA Technical Reports Server (NTRS)

    1980-01-01

    The HYBRID2 program which computes the fuel and energy consumption of a hybrid vehicle with a bi-modal control strategy over specified component driving cycles is described. Fuel and energy consumption are computed separately for the two modes of operation. The program also computes yearly average fuel and energy consumption using a composite driving cycle which varies as a function of daily travel. The modelling techniques are described, and subroutines and their functions are given. The composition of modern automobiles is discussed along with the energy required to manufacture an American automobile. The energy required to scrap and recycle automobiles is also discussed.

  12. Matrix effects in the C 1s photoabsorption spectra of condensed naphthalene

    NASA Astrophysics Data System (ADS)

    Schmidt, Norman; Wenzel, Jan; Dreuw, Andreas; Fink, Rainer H.; Hieringer, Wolfgang

    2016-12-01

    High-resolution C 1s near-edge x-ray absorption fine structure (NEXAFS) spectra of naphthalene are investigated. By comparing the spectral signatures of condensed naphthalene molecules with those of naphthalene in the gas phase, we are able to unambiguously identify spectral features which are affected by the intermolecular interactions in the condensed phase. With the help of calculations using time-dependent density-functional theory and the second-order algebraic-diagrammatic construction scheme for the polarization propagator, resonances in the relevant energy range can be assigned to valence and Rydberg-like excitations. Thus, we obtain a more detailed identification of NEXAFS resonances beyond the present literature.

  13. Near-ultraviolet spectroscopy of Comet Austin (1989c1)

    NASA Technical Reports Server (NTRS)

    Valk, Jacobus H.; O'Dell, C. R.; Cochran, Anita L.; Cochran, William D.; Opal, Chet B. S.; Barker, Edwin S.

    1992-01-01

    Comet Austin (1989c1) was observed post-perihelion at a heliocentric distance near 1.25 AU. The wavelength range was from the atmospheric cutoff at 3000 to 4000 A. The coma spectra were calibrated into flux units and the contaminating sky spectrum and solar scattered light continuum were subtracted, leaving an ultraviolet spectrum of about 1.5-A resolution and excellent signal-to-noise ratio. The spectrum is dominated by emissions from OH, NH, CH, C3, and CN, some of the weaker emissions of which are seen here for the first time. More bands of CO(2+) were found than in any previous investigation and several intensity anomalies were noted; H2CO, OH(+), NCN, N(2+), and CN(+) may be present. Several emission features well above the noise level remain unidentified. The relative intensities of the OH and CN bands agree with the predictions of resonance fluorescence when one considers the potential effects of contamination by other molecules. The effects of the ozone absorption spectrum are not fully removed by the data-reduction process, although this does not affect these results.

  14. Construction of knowledge about teaching practice and educating students from diverse cultures in an online induction program

    NASA Astrophysics Data System (ADS)

    Bice, Lawrence Raymond

    2005-11-01

    Beginning teachers in both urban areas and geographically isolated rural areas often do not have access to a mentor teacher of the same content area or grade level in their school or district. This project is a study of learning in the on-line e-Mentoring for Student Success (eMSS) program, which provides induction for science and mathematics teachers in Montana and California. The study centered on a particular segment of eMSS called the Diversity Module. Two examinations were conducted: (1) Analysis of discourse by all participants in the Diversity Module, and (2) case study of five beginning teachers with diverse student populations. Analysis of learning by cases was conducted by examining discourse in the Diversity Module, private on-line discussions with their assigned mentors during a two-year period, and pre and post Diversity Module interviews and interviews of their mentors. Three frameworks were developed to aid understanding of findings: (1) discourse analysis, (2) competencies of multicultural teachers, and, (3) competencies of pedagogical and pedagogical content knowledge. Cases developed their knowledge of teaching along a continuum of needs over two years of participation in the eMSS program. Initial needs expressed by mentees were in areas such as classroom management and general methods of instruction. Cases increased their knowledge in virtually all aspects of pedagogical knowledge, changing their expressed needs to pedagogical content knowledge concerns such as adapting and differentiating instruction for particular content and individual students, and building their repertoire of instructional representations. Through on-line discussion, teachers developed or advanced awareness of student culture and learning characteristics, and adapted their practice to foster a climate of student respect. Findings provided little evidence of adapting instruction for diverse student learning. Teachers who had a strong awareness of their own and their students

  15. Qualitative assessment of the residential-building-construction market and its implications for the Building Energy Performance Standards program

    SciTech Connect

    Wolff, D.C.

    1980-08-01

    The purpose of BEPS is to force builders and home-buyers to make decisions that are in the national interest as well as their own: decisions which, it is argued, are unlikely to be made without BEPS, given the lack of builder and consumer awareness about conservation, given the existing regulatory framework within which fuels are priced and allocated, and given existing lending practices. BEPS' requirement that energy efficiency be achieved, in addition to its manual on ways of meeting BEPS, should go a long way toward remedying the problem. BEPS can force consumers to see the actual costs of the energy they use in their homes by using state-level marginal energy prices to set Design Energy Budget levels which require the right amount of conservation for each type of house in each region. Finally, it is within the capability of the BEPS framework for the program to modify lending practices to alleviate the first-cost problem posed by BEPS.

  16. Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms.

    PubMed

    Emadali, Anouk; Hoghoughi, Neda; Duley, Samuel; Hajmirza, Azadeh; Verhoeyen, Els; Cosset, Francois-Loic; Bertrand, Philippe; Roumier, Christophe; Roggy, Anne; Suchaud-Martin, Céline; Chauvet, Martine; Bertrand, Sarah; Hamaidia, Sieme; Rousseaux, Sophie; Josserand, Véronique; Charles, Julie; Templier, Isabelle; Maeda, Takahiro; Bruder-Costa, Juliana; Chaperot, Laurence; Plumas, Joel; Jacob, Marie-Christine; Bonnefoix, Thierry; Park, Sophie; Gressin, Remy; Tensen, Cornelis P; Mecucci, Cristina; Macintyre, Elizabeth; Leroux, Dominique; Brambilla, Elisabeth; Nguyen-Khac, Florence; Luquet, Isabelle; Penther, Dominique; Bastard, Christian; Jardin, Fabrice; Lefebvre, Christine; Garnache, Francine; Callanan, Mary B

    2016-06-16

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive leukemia for which knowledge on disease mechanisms and effective therapies are currently lacking. Only a handful of recurring genetic mutations have been identified and none is specific to BPDCN. In this study, through molecular cloning in an index case that presented a balanced t(3;5)(q21;q31) and molecular cytogenetic analyses in a further 46 cases, we identify monoallelic deletion of NR3C1 (5q31), encoding the glucocorticoid receptor (GCR), in 13 of 47 (28%) BPDCN patients. Targeted deep sequencing in 36 BPDCN cases, including 10 with NR3C1 deletion, did not reveal NR3C1 point mutations or indels. Haploinsufficiency for NR3C1 defined a subset of BPDCN with lowered GCR expression and extremely poor overall survival (P = .0006). Consistent with a role for GCR in tumor suppression, functional analyses coupled with gene expression profiling identified corticoresistance and loss-of-EZH2 function as major downstream consequences of NR3C1 deletion in BPDCN. Subsequently, more detailed analyses of the t(3;5)(q21;q31) revealed fusion of NR3C1 to a long noncoding RNA (lncRNA) gene (lincRNA-3q) that encodes a novel, nuclear, noncoding RNA involved in the regulation of leukemia stem cell programs and G1/S transition, via E2F. Overexpression of lincRNA-3q was a consistent feature of malignant cells and could be abrogated by bromodomain and extraterminal domain (BET) protein inhibition. Taken together, this work points to NR3C1 as a haploinsufficient tumor suppressor in a subset of BPDCN and identifies BET inhibition, acting at least partially via lncRNA blockade, as a novel treatment option in BPDCN.

  17. Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms

    PubMed Central

    Emadali, Anouk; Hoghoughi, Neda; Duley, Samuel; Hajmirza, Azadeh; Verhoeyen, Els; Cosset, Francois-Loic; Bertrand, Philippe; Roumier, Christophe; Roggy, Anne; Suchaud-Martin, Céline; Chauvet, Martine; Bertrand, Sarah; Hamaidia, Sieme; Rousseaux, Sophie; Josserand, Véronique; Charles, Julie; Templier, Isabelle; Maeda, Takahiro; Bruder-Costa, Juliana; Chaperot, Laurence; Plumas, Joel; Jacob, Marie-Christine; Bonnefoix, Thierry; Park, Sophie; Gressin, Remy; Tensen, Cornelis P.; Mecucci, Cristina; Macintyre, Elizabeth; Leroux, Dominique; Brambilla, Elisabeth; Nguyen-Khac, Florence; Luquet, Isabelle; Penther, Dominique; Bastard, Christian; Jardin, Fabrice; Lefebvre, Christine; Garnache, Francine

    2016-01-01

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive leukemia for which knowledge on disease mechanisms and effective therapies are currently lacking. Only a handful of recurring genetic mutations have been identified and none is specific to BPDCN. In this study, through molecular cloning in an index case that presented a balanced t(3;5)(q21;q31) and molecular cytogenetic analyses in a further 46 cases, we identify monoallelic deletion of NR3C1 (5q31), encoding the glucocorticoid receptor (GCR), in 13 of 47 (28%) BPDCN patients. Targeted deep sequencing in 36 BPDCN cases, including 10 with NR3C1 deletion, did not reveal NR3C1 point mutations or indels. Haploinsufficiency for NR3C1 defined a subset of BPDCN with lowered GCR expression and extremely poor overall survival (P = .0006). Consistent with a role for GCR in tumor suppression, functional analyses coupled with gene expression profiling identified corticoresistance and loss-of-EZH2 function as major downstream consequences of NR3C1 deletion in BPDCN. Subsequently, more detailed analyses of the t(3;5)(q21;q31) revealed fusion of NR3C1 to a long noncoding RNA (lncRNA) gene (lincRNA-3q) that encodes a novel, nuclear, noncoding RNA involved in the regulation of leukemia stem cell programs and G1/S transition, via E2F. Overexpression of lincRNA-3q was a consistent feature of malignant cells and could be abrogated by bromodomain and extraterminal domain (BET) protein inhibition. Taken together, this work points to NR3C1 as a haploinsufficient tumor suppressor in a subset of BPDCN and identifies BET inhibition, acting at least partially via lncRNA blockade, as a novel treatment option in BPDCN. PMID:27060168

  18. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.

    PubMed

    McGreal, Eamon P; Ikewaki, Nobunao; Akatsu, Hiroyasu; Morgan, B Paul; Gasque, Philippe

    2002-05-15

    It has been suggested that the human C1qRp is a receptor for the complement component C1q; however, there is no direct evidence for an interaction between C1q and C1qRp. In this study, we demonstrate that C1q does not show enhanced binding to C1qRp-transfected cells compared with control cells. Furthermore, a soluble recombinant C1qRp-Fc chimera failed to interact with immobilized C1q. The proposed role of C1qRp in the phagocytic response in vivo is also unsupported in that we demonstrate that this molecule is not expressed by macrophages in a variety of human tissues and the predominant site of expression is on endothelial cells. Studies on the rodent homolog of C1qRp, known as AA4, have suggested that this molecule may function as an intercellular adhesion molecule. Here we show that C1qRp is the Ag recognized by several previously described mAbs, mNI-11 and two anti-CD93 Abs (clones X2 and VIMD2b). Interestingly, mNI-11 (Fab') has been shown to promote monocyte-monocyte and monocyte-endothelial cell adhesive interactions. We produced a recombinant C1qRp-Fc chimera containing the C-type lectin-like domain of C1qRp and found specific binding to vascular endothelial cells in sections of inflamed human tonsil, indicating the presence of a C1qRp ligand at this site. This interaction was Ca(2+) independent and was not blocked by our anti-C1qRp mAb BIIG-4, but was blocked by the proadhesive mAb mNI-11. Collectively, these data indicate that C1qRp is not a receptor for C1q, and they support the emerging role of C1qRp (here renamed CD93) in functions relevant to intercellular adhesion.

  19. Passageway: A Novel Approach to Success of Conditional Release - Principles and Constructs of the Model Residential Program for the Forensic Mentally III Patient.

    PubMed

    Melnick, Ilan

    2016-03-01

    With the advent of psychotropic medications and with the deinstitutionalization of psychiatry starting in 1968, patients were prematurely discharged from forensic state hospitals. Due to lack of resources, psychiatric forensic patients ended up in the correctional system or homeless with the reduction of psychiatric beds in forensic and civil state hospitals. Lacking proper training and medication management, the recidivism rate of this population was close to 10% for rearrest and about 35% for revocation of conditional release (CR; Manguno-Mire et al., ). A new treatment modality was created to successfully transition patients from the forensic state hospital system to the community. This article describes and analyzes the principles and constructs of Passageway, a model residential program for patients found not guilty by reason of insanity or those incompetent to proceed to CR. The CR allows for a program like Passageway to be successful in transitioning patients back into the community. This is accomplished with minimal government funding, and since 1982 has resulted in a 0% recidivism rate, for any known arrests or convictions and for recommittal of a felony, defined in the state of Florida as, "any criminal offense that is punishable under the laws of this state, or that would be punishable, if committed in this state, by death or imprisonment in a state penitentiary. " (Fla. Stat. § 775.08). Copyright © 2016 John Wiley & Sons, Ltd.

  20. The students' interest for 2012 and 2013 cohort in construction engineering vocational education program Universitas Negeri Semarang in choosing the subject specialization

    NASA Astrophysics Data System (ADS)

    Julianto, Eko Nugroho; Salamah, Ummu

    2017-03-01

    On the 2012 curriculum, Vocational Education Program Universitas Negeri Semarang allowed the students to choose subjects for their specialization according to their ability. The subject specialization was given at the 6th semester to provide students in performing field work experience. Each course has its own enthusiasts specialization, students have certain considerations in selecting the course. The consideration of each of them is different from one another because they have their own talents, interests, aspirations and perceptions or a different view in assessing a subject specialization offered by Construction Engineering Vocational Education Program. The purpose of this study was to determine the amount of interest caused by intrinsic and extrinsic factors on 2012 and 2013 students' cohort in selecting subjects of specialization. This research is descriptive with quantitative approach, which is carried out to determine the magnitude of the interest students in choosing courses of specialization. Research conducted at the Civil Engineering Department Universitas Negeri Semarang, with research subjects that students PTB forces in 2012 and 2013, with a total sample of 87 students. The results showed that the interest of the student of 2012 and 2013 in selecting subjects of specialization is equal to 68.06% with the criteria are interested in contributions from intrinsic factors indicate the yield at 35.48% and 64.52% extrinsic factors.

  1. Fabrication of dye-sensitized solar cells using chlorophylls c1 and c2 and their oxidized forms c1' and c2' from Undaria pinnatifida (Wakame)

    NASA Astrophysics Data System (ADS)

    Wang, Xiao-Feng; Zhan, Cong-Hong; Maoka, Takashi; Wada, Yuji; Koyama, Yasushi

    2007-10-01

    Two different types of chlorophyll c ( c1 and c2) and their oxidized forms ( c1' and c2') were isolated from a brown seaweed, Undaria pinnatifida, and their structures were determined by mass spectrometry and 1H NMR spectroscopy. The order of conversion efficiencies in titania-based solar cells using these chlorophyll sensitizers, i.e., c2(4.6%)>c1(3.4%)>c2'(2.6%)≧c1'(2.5%), were explained in terms of a more extended conjugated system and the resultant higher electron densities in Chl c2 than Chl c1 as well as the different configurations and electron densities of the vinyl carboxyl group in Chls c2' and c1'.

  2. The production and secretion of complement component C1q by human mast cells.

    PubMed

    van Schaarenburg, Rosanne A; Suurmond, Jolien; Habets, Kim L L; Brouwer, Mieke C; Wouters, Diana; Kurreeman, Fina A S; Huizinga, Tom W J; Toes, René E M; Trouw, Leendert A

    2016-10-01

    C1q is the initiation molecule of the classical pathway of the complement system and is produced by macrophages and immature dendritic cells. As mast cells share the same myeloid progenitor cells, we have studied whether also mast cells can produce and secrete C1q. Mast cells were generated in vitro from CD34+ progenitor cells from buffy coats or cord blood. Fully differentiated mast cells were shown by both RNA sequencing and qPCR to express C1QA, C1QB and C1QC. C1q produced by mast cells has a similar molecular make-up as serum C1q. Reconstituting C1q depleted serum with mast cell supernatant in haemolytic assays, indicated that C1q secreted by mast cells is functionally active. The level of C1q in supernatants produced under basal conditions was considerably enhanced upon stimulation with LPS, dexamethasone in combination with IFN- γ or via FcεRI triggering. Mast cells in human tissues stained positive for C1q in both healthy and in inflamed tissue. Moreover, mast cells in healthy and diseased skin appear to be the predominant C1q positive cells. Together, our data reveal that mast cells are able to produce and secrete functional active C1q and indicate mast cells as a local source of C1q in human tissue.

  3. C1 finite elements on non-tensor-product 2d and 3d manifolds

    PubMed Central

    Nguyen, Thien; Karčiauskas, Kęstutis; Peters, Jörg

    2015-01-01

    Geometrically continuous (Gk) constructions naturally yield families of finite elements for isogeometric analysis (IGA) that are Ck also for non-tensor-product layout. This paper describes and analyzes one such concrete C1 geometrically generalized IGA element (short: gIGA element) that generalizes bi-quadratic splines to quad meshes with irregularities. The new gIGA element is based on a recently-developed G1 surface construction that recommends itself by its a B-spline-like control net, low (least) polynomial degree, good shape properties and reproduction of quadratics at irregular (extraordinary) points. Remarkably, for Poisson’s equation on the disk using interior vertices of valence 3 and symmetric layout, we observe O(h3) convergence in the L∞ norm for this family of elements. Numerical experiments confirm the elements to be effective for solving the trivariate Poisson equation on the solid cylinder, deformations thereof (a turbine blade), modeling and computing geodesics on smooth free-form surfaces via the heat equation, for solving the biharmonic equation on the disk and for Koiter-type thin-shell analysis. PMID:26594070

  4. C(1) finite elements on non-tensor-product 2d and 3d manifolds.

    PubMed

    Nguyen, Thien; Karčiauskas, Kęstutis; Peters, Jörg

    2016-01-01

    Geometrically continuous (G(k) ) constructions naturally yield families of finite elements for isogeometric analysis (IGA) that are C(k) also for non-tensor-product layout. This paper describes and analyzes one such concrete C(1) geometrically generalized IGA element (short: gIGA element) that generalizes bi-quadratic splines to quad meshes with irregularities. The new gIGA element is based on a recently-developed G(1) surface construction that recommends itself by its a B-spline-like control net, low (least) polynomial degree, good shape properties and reproduction of quadratics at irregular (extraordinary) points. Remarkably, for Poisson's equation on the disk using interior vertices of valence 3 and symmetric layout, we observe O(h(3)) convergence in the L(∞) norm for this family of elements. Numerical experiments confirm the elements to be effective for solving the trivariate Poisson equation on the solid cylinder, deformations thereof (a turbine blade), modeling and computing geodesics on smooth free-form surfaces via the heat equation, for solving the biharmonic equation on the disk and for Koiter-type thin-shell analysis.

  5. C1 CHEMISTRY FOR THE PRODUCTION OF ULTRA-CLEAN LIQUID TRANSPORTATION FUELS AND HYDROGEN

    SciTech Connect

    Gerald P. Huffman

    2004-09-30

    The Consortium for Fossil Fuel Science (CFFS) is a research consortium with participants from the University of Kentucky, University of Pittsburgh, West Virginia University, University of Utah, and Auburn University. The CFFS is conducting a research program to develop C1 chemistry technology for the production of clean transportation fuel from resources such as coal and natural gas, which are more plentiful domestically than petroleum. The processes under development will convert feedstocks containing one carbon atom per molecular unit into ultra clean liquid transportation fuels (gasoline, diesel, and jet fuel) and hydrogen, which many believe will be the transportation fuel of the future. Feedstocks include synthesis gas, a mixture of carbon monoxide and hydrogen produced by coal gasification, coalbed methane, light products produced by Fischer-Tropsch (FT) synthesis, methanol, and natural gas.

  6. Self-assembly of Carbon Vacancies in Sub-stoichiometric ZrC1−x

    PubMed Central

    Zhang, Yanhui; Liu, Bin; Wang, Jingyang

    2015-01-01

    Sub-stoichiometric interstitial compounds, including binary transition metal carbides (MC1−x), maintain structural stability even if they accommodate abundant anion vacancies. This unique character endows them with variable-composition, diverse-configuration and controllable-performance through composition and structure design. Herein, the evolution of carbon vacancy (VC) configuration in sub-stoichiometric ZrC1−x is investigated by combining the cluster expansion method and first-principles calculations. We report the interesting self-assembly of VCs and the fingerprint VC configuration (VC triplet constructed by 3rd nearest neighboring vacancies) in all the low energy structures of ZrC1−x. When VC concentration is higher than the critical value of 0.5 (x > 0.5), the 2nd nearest neighboring VC configurations with strongly repulsive interaction inevitably appear, and meanwhile, the system energy (or formation enthalpy) of ZrC1−x increases sharply which suggests the material may lose phase stability. The present results clarify why ZrC1−x bears a huge amount of VCs, tends towards VC ordering, and retains stability up to a stoichiometry of x = 0.5. PMID:26667083

  7. Preface: phys. stat. sol. (c) 1/9

    NASA Astrophysics Data System (ADS)

    Leitch, Andrew; Botha, Reinhardt

    2004-08-01

    The Conference on Photo-responsive Materials took place at the Kariega Game Reserve in the Eastern Cape, South Africa from 25-29 February 2004. More than 60 delegates from 12 different countries participated in the four-day event.The purpose of the conference was to bring together scientists working on various aspects of photo-responsive materials, so as to stimulate this important field of solid state physics in Southern Africa. As may be seen from the list of papers appearing in these proceedings, there was much interest in copper indium diselenide as a thin film material for photovoltaic applications. Also worth mentioning were the valuable contributions on ZnO, GaN and other materials that are currently attracting attention worldwide.The conference program allowed sufficient time for interaction and exchanging of views. Being in a game reserve in the heart of the beautiful Eastern Cape, delegates were also taken on game drives and had the opportunity of taking a river cruise up the Kariega River to view the majestic fish eagle.The members of the academic program committee were: Vivian Alberts (Rand Afrikaans University), Danie Auret (University of Pretoria), Darrell Comins (University of the Witwatersrand), and Reinhardt Botha and Andrew Leitch (University of Port E All papers appearing in these proceedings underwent a strict reviewing process separate from the conference. We express our appreciation to the referees for their diligence in this important task. The conference was organized by the Department of Physics at the University of Port Elizabeth, under the auspices of the Condensed Matter Physics and Materials Science (CMPMS) subgroup of the South African Institute of Physics. It was sponsored by EMF Limited (UK), Sensors Unlimited Inc. (USA), and Carl Zeiss (Pty) Ltd. Special thanks must go to Dr Eunete van Wyk for her professional assistance in the preparation of these proceedings.

  8. Lack of increased prevalence of immunoregulatory disorders in hereditary angioedema due to C1-inhibitor deficiency.

    PubMed

    Farkas, Henriette; Csuka, Dorottya; Gács, Judit; Czaller, Ibolya; Zotter, Zsuzsanna; Füst, George; Varga, Lilian; Gergely, Péter

    2011-10-01

    Hereditary angioedema due to deficiency of C1-INH (HAE-C1-INH) is associated with enhanced consumption of the early complement components, which may predispose for autoimmune disease. We assessed the prevalence of such disorders among HAE- C1-INH patients and their impact on the natural course of HAE-C1-INH. Clinical data and immunoserological parameters of 130 HAE-C1-INH and 174 non-C1-INH-deficient patients with angioedema were analyzed. In our study, the incidence of immunoregulatory disorders was 11.5% in the population of HAE-C1-INH patients and 5.2% among non-C1-INH-deficient controls with angioedema. Immunoserology screening revealed a greater prevalence of anticardiolipin IgM (p=0.0118) among HAE-C1-INH patients, than in those with non-C1-INH-deficient angioedema. We did not find higher prevalence of immunoregulatory disorders among our HAE-C1-INH patients. However, in patients with confirmed immunoregulatory disorders, the latter influenced both the severity of HAE-C1-INH and the effectiveness of its long-term management. Appropriate management of the immunoregulatory disease thus identified improves the symptoms of HAE-C1-INH.

  9. Human diploid fibroblasts have receptors for the globular domain of C1Q

    SciTech Connect

    Bordin, S.; Page, R.C.

    1986-03-01

    The authors showed that mass cultures of fibroblasts grown from gingival explants in DB medium with 10% human serum are enriched in a phenotype that binds C1q with an affinity much higher than the rest of the population. Because of potential biologic importance of C1q receptors, the authors studied whether the interaction between C1q and this phenotype was mediated by the globular or collagenous domains of the molecule. Globular fragments were prepared by digesting C1q with collagenase, and collagenous fragments obtained after pepsin treatment. C1q binding on cells in suspension was determined by reaction with /sup 125/I-C1q as reported. Competition experiments were performed under conditions in which intact /sup 125/I-C1q binding saturated all available receptors. The results showed that collagenous fragments inhibited 20% of the /sup 125/I-C1q binding to high affinity receptors, whereas inhibition by globular fragments was 70%. Unlabeled intact C1q and collagen type 1 were used as controls, and inhibited 92% and 17% of C1q binding, respectively. These studies show that C1q interacts with the fibroblast phenotype expressing high affinity receptors through its globular domain. The authors suggest that at sites of trauma, native C1 may bind to the surface of these cells via the globular domain of C1q, and that this unique phenotype may play an important role in tissue repair.

  10. In silico structural characteristics and α-amylase inhibitory properties of Ric c 1 and Ric c 3, allergenic 2S albumins from Ricinus communis seeds.

    PubMed

    Do Nascimento, Viviane Veiga; Castro, Helena Carla; Abreu, Paula Alvarez; Oliveira, Antônia Elenir Amâncio; Fernandez, Jorge Hernandez; Araújo, Jucélia Da Silva; Machado, Olga Lima Tavares

    2011-05-11

    The major Ricinus communis allergens are the 2S albumins, Ric c 1 and Ric c 3. These proteins contain a trypsin/α-amylase inhibitor family domain, suggesting that they have a role in insect resistance. In this study, we verified that Ric c 1 and Ric c 3 inhibited the α-amylase activity of Callosobruchus maculatus, Zabrotes subfasciatus, and Tenebrio molitor (TMA) larvae as well as mammalian α-amylase. The toxicity of 2S albumin was determined through its incorporation in C. maculatus larvae as part of an artificial diet. Bioassays revealed that 2S albumin reduced larval growth by 20%. We also analyzed the tridimensional structures of Ric c 1 and Ric c 3 by (a) constructing a comparative model of Ric c 1 based on Ric c 3 NMR structure and (b) constructing the theoretical structure of the Ric c 1-TMA and Ric c 3-TMA complexes. Our biological and theoretical results revealed that Ric c 1 and Ric c 3 are a new class of α-amylase inhibitors. They could potentially be used to help design inhibitors that would be useful in diverse fields, ranging from diabetes treatment to crop protection.

  11. Aviation Safety Modeling and Simulation (ASMM) Propulsion Fleet Modeling: A Tool for Semi-Automatic Construction of CORBA-based Applications from Legacy Fortran Programs

    NASA Technical Reports Server (NTRS)

    Sang, Janche

    2003-01-01

    Within NASA's Aviation Safety Program, NASA GRC participates in the Modeling and Simulation Project called ASMM. NASA GRC s focus is to characterize the propulsion systems performance from a fleet management and maintenance perspective by modeling and through simulation predict the characteristics of two classes of commercial engines (CFM56 and GE90). In prior years, the High Performance Computing and Communication (HPCC) program funded, NASA Glenn in developing a large scale, detailed simulations for the analysis and design of aircraft engines called the Numerical Propulsion System Simulation (NPSS). Three major aspects of this modeling included the integration of different engine components, coupling of multiple disciplines, and engine component zooming at appropriate level fidelity, require relatively tight coupling of different analysis codes. Most of these codes in aerodynamics and solid mechanics are written in Fortran. Refitting these legacy Fortran codes with distributed objects can increase these codes reusability. Aviation Safety s modeling and simulation use in characterizing fleet management has similar needs. The modeling and simulation of these propulsion systems use existing Fortran and C codes that are instrumental in determining the performance of the fleet. The research centers on building a CORBA-based development environment for programmers to easily wrap and couple legacy Fortran codes. This environment consists of a C++ wrapper library to hide the details of CORBA and an efficient remote variable scheme to facilitate data exchange between the client and the server model. Additionally, a Web Service model should also be constructed for evaluation of this technology s use over the next two- three years.

  12. ClC-1 and ClC-2 form hetero-dimeric channels with novel protopore functions.

    PubMed

    Stölting, Gabriel; Fischer, Martin; Fahlke, Christoph

    2014-12-01

    CLC-type chloride channels exhibit a unique double-barreled architecture with two independently functioning ion conduction pathways, the so-called protopores. There exist gating processes that open and close individual protopores as well as common processes that jointly mediate slow opening and closing of both protopores. Different isoforms exhibit distinct voltage dependences and kinetics of gating. Whereas opening of the individual and common gate of homo-dimeric ClC-1 is promoted by membrane depolarization, ClC-2 is closed at positive potentials and opens only at negative voltages. To characterize the functional interaction of protopores we engineered a concatameric construct linking the coding regions of ClC-1 and ClC-2 in an open reading frame, expressed it in mammalian cells and measured anion currents through whole-cell and single channel patch clamping. In the hetero-dimeric assembly, each protopore displayed two kinetically distinct gating processes. Fast gating of the ClC-1 protopore closely resembled fast protopore gating of homo-dimeric channels. The voltage dependence of ClC-2 fast gating was shifted to more positive potentials by the adjacent ClC-1 protopore, resulting in open ClC-2 protopores at positive voltages. We observed two slow gating processes individually acting on ClC-1 and ClC-2 protopores, with distinct time and voltage dependences. Single channel recordings demonstrated that hetero-dimerization additionally modified the unitary conductance of ClC-2 protopores. Our findings suggest that inter-subunit interactions do not only affect common gating, but also ion permeation and gating of individual protopores in hetero-dimeric ClC channels.

  13. 26 CFR 1.860C-1 - Taxation of holders of residual interests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Taxation of holders of residual interests. 1.860C-1 Section 1.860C-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860C-1 Taxation of...

  14. 26 CFR 301.6230(c)-1 - Claim arising out of erroneous computation, etc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Claim arising out of erroneous computation, etc. 301.6230(c)-1 Section 301.6230(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE....6230(c)-1 Claim arising out of erroneous computation, etc. (a) In general. A claim for refund...

  15. 26 CFR 1.673(c)-1 - Reversionary interest after income beneficiary's death.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Reversionary interest after income beneficiary's death. 1.673(c)-1 Section 1.673(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Substantial Owners § 1.673(c)-1 Reversionary interest after income beneficiary's death. The subject matter...

  16. 26 CFR 1.673(c)-1 - Reversionary interest after income beneficiary's death.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Reversionary interest after income beneficiary's death. 1.673(c)-1 Section 1.673(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Substantial Owners § 1.673(c)-1 Reversionary interest after income beneficiary's death. The subject matter...

  17. 26 CFR 1.673(c)-1 - Reversionary interest after income beneficiary's death.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Reversionary interest after income beneficiary's death. 1.673(c)-1 Section 1.673(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Substantial Owners § 1.673(c)-1 Reversionary interest after income beneficiary's death. The subject matter...

  18. 26 CFR 1.673(c)-1 - Reversionary interest after income beneficiary's death.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... § 1.673(c)-1 Reversionary interest after income beneficiary's death. The subject matter of section 673... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Reversionary interest after income beneficiary's death. 1.673(c)-1 Section 1.673(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  19. 26 CFR 1.673(c)-1 - Reversionary interest after income beneficiary's death.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Substantial Owners § 1.673(c)-1 Reversionary interest after income beneficiary's death. The subject matter of... 26 Internal Revenue 8 2013-04-01 2013-04-01 false Reversionary interest after income beneficiary's death. 1.673(c)-1 Section 1.673(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  20. 17 CFR 270.23c-1 - Repurchase of securities by closed-end companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... closed-end companies. 270.23c-1 Section 270.23c-1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT COMPANY ACT OF 1940 § 270.23c-1 Repurchase of securities by closed-end companies. (a) A registered closed-end company may purchase for cash...

  1. 26 CFR 1.674(c)-1 - Excepted powers exercisable only by independent trustees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... trustees. 1.674(c)-1 Section 1.674(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... § 1.674(c)-1 Excepted powers exercisable only by independent trustees. Section 674(c) provides an exception to the general rule of section 674(a) for certain powers that are exercisable by...

  2. 26 CFR 1.674(c)-1 - Excepted powers exercisable only by independent trustees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... trustees. 1.674(c)-1 Section 1.674(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Substantial Owners § 1.674(c)-1 Excepted powers exercisable only by independent trustees. Section 674(c) provides an exception to the general rule of section 674(a) for certain powers that are exercisable...

  3. The soluble recombinant form of a binding protein/receptor for the globular domain of C1q (gC1qR) enhances blood coagulation.

    PubMed

    Peerschke, E I; Jesty, J; Reid, K B; Ghebrehiwet, B

    1998-01-01

    The gC1qR is a ubiquitously expressed, 33 kDa cellular protein which recognizes the globular domains of C1q. Recent evidence suggests that the gC1qR also serves as the Zn(++)-dependent endothelial cell binding site for factor XII and high-molecular-weight kininogen, and activates intrinsic coagulation and kinin pathways in purified systems. In addition, activated lymphocytes have been reported to release soluble gC1qR. Thus, the present study investigated the procoagulant potential of soluble gC1qR in human plasma using the recombinant protein (rgC1qR). rgC1qR supported a dose-dependent shortening of extrinsic coagulation using the prothrombin time in the presence of diluted (1/50-1/500) thromboplastin. Maximum enhancement of the prothrombin time resulted in shortening of the clotting time from 78.8 +/- 0.4 s to 68.5 +/- 0.6 s (mean +/- SD, n = 8) in the presence of 50 micrograms/ml (1.5 mumol/l) rgC1qR. rgC1qR also enhanced the intrinsic pathway of coagulation evaluated in the absence of activators of the contact system, as demonstrated by a shortening of the plasma recalcification time from 348 +/- 66 s to 140 +/- 23 s (n = 4). rgC1qR, however, had no effect on intrinsic coagulation in the presence of undiluted kaolin or ellagic acid, and under these conditions failed to shorten the activated partial thromboplastin time of factor VIII or factor-IX-deficient plasma. rgC1qR further failed to affect thrombin and factor Xa generation assayed using chromogenic substrates, and did not enhance thrombin-induced conversion of fibrinogen to fibrin. Interestingly, the procoagulant activity of the rgC1qR was measurable in either factor-XII- or factor-XI-deficient plasma, suggesting that it was not exclusively focused on the contact system of coagulation. Although the mechanism of action of gC1qR on blood coagulation remains obscure, the data suggest a potential role for this protein in hemostatic and thrombotic events.

  4. Constructed Wetlands

    EPA Pesticide Factsheets

    these systems can improve water quality, engineers and scientists construct systems that replicate the functions of natural wetlands. Constructed wetlands are treatment systems that use natural processes

  5. Preface: phys. stat. sol. (c) 1/7

    NASA Astrophysics Data System (ADS)

    Cheikhrouhou, Abdelwaheb

    2004-05-01

    Physics Laboratory, Sciences Faculty of Sfax (Tunisia) and the Co-Chairmen were Professor Sami Mahmood, Dean of Sciences at Yarmouk University (Jordan) and Professor Mohamed Akhavan from the Sharif University of Technology (Iran). The four-day conference consisted of several oral and poster sessions, followed by social programs in the evenings. The success of the event could be measured during the closing session on the last day, when several delegates emphasized the high-quality science that had been evident at the conference. A post conference three-day tour to the south of Tunisia (Matmata, Douz City: the gate of desert and the mountains oasis: Tamerza, Mides and Chebika) was also arranged. The conference was generously sponsored by: - The Tunisian Ministry of High Education, Scientific Research and Technology - The Tunisian Secretary of State for Scientific Research and Technology - The Tunisian National Office of Tourism - The Abdus Salam International Centre for Theoretical Physics (ICTP) - French Institute for Cooperation in Tunisia - Tunisian-Italian Scientific Partnership - British Gas - Tunisian Society for Electricity and Gas - Imex Olive Oil -Confiserie TRIKI Le Moulin The next MSM conference in 2005 will be held in Morocco.

  6. Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.

    PubMed

    Feng, Shengmei; Zhu, Guochun; McConnell, Matthew; Deng, Lianfu; Zhao, Qiang; Wu, Mengrui; Zhou, Qi; Wang, Jinshen; Qi, Jin; Li, Yi-Ping; Chen, Wei

    2013-01-01

    Previous studies have shown that Atp6v1c1, a regulator of the assembly of the V0 and V1 domains of the V-ATPase complex, is up-regulated in metastatic oral tumors. Despite these studies, the function of Atp6v1c1 in tumor growth and metastasis is still unknown. Atp6v1c1's expression in metastatic oral squamous cell carcinoma indicates that Atp6v1c1 has an important function in cancer growth and metastasis. We hypothesized that elevated expression of Atp6v1c1 is essential to cancer growth and metastasis and that Atp6v1c1 promotes cancer growth and metastasis through activation of V-ATPase activity. To test this hypothesis, a Lentivirus-mediated RNAi knockdown approach was used to study the function of Atp6v1c1 in mouse 4T1 mammary tumor cell proliferation and migration in vitro and cancer growth and metastasis in vivo. Our data revealed that silencing of Atp6v1c1 in 4T1 cancer cells inhibited lysosomal acidification and severely impaired 4T1 cell growth, migration, and invasion through Matrigel in vitro. We also show that Atp6v1c1 knockdown with Lenti-c1s3, a lentivirus targeting Atp6v1c1 for shRNA mediated knockdown, can significantly inhibit 4T1 xenograft tumor growth, metastasis, and osteolytic lesions in vivo. Our study demonstrates that Atp6v1c1 may promote breast cancer growth and bone metastasis through regulation of lysosomal V-ATPase activity, indicating that Atp6v1c1 may be a viable target for breast cancer therapy and silencing of Atp6v1c1 may be an innovative therapeutic approach for the treatment and prevention of breast cancer growth and metastasis.

  7. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1995-01-01

    Part of the 1994 Industrial Minerals Review. The production, consumption, and applications of construction aggregates are reviewed. In 1994, the production of construction aggregates, which includes crushed stone and construction sand and gravel combined, increased 7.7 percent to 2.14 Gt compared with the previous year. These record production levels are mostly a result of funding for highway construction work provided by the Intermodal Surface Transportation Efficiency Act of 1991. Demand is expected to increase for construction aggregates in 1995.

  8. Designing of skull defect implants using C1 rational cubic Bezier and offset curves

    NASA Astrophysics Data System (ADS)

    Mohamed, Najihah; Majid, Ahmad Abd; Piah, Abd Rahni Mt; Rajion, Zainul Ahmad

    2015-05-01

    Some of the reasons to construct skull implant are due to head trauma after an accident or an injury or an infection or because of tumor invasion or when autogenous bone is not suitable for replacement after a decompressive craniectomy (DC). The main objective of our study is to develop a simple method to redesign missing parts of the skull. The procedure begins with segmentation, data approximation, and estimation process of the outer wall by a C1 continuous curve. Its offset curve is used to generate the inner wall. A metaheuristic algorithm, called harmony search (HS) is a derivative-free real parameter optimization algorithm inspired from the musical improvisation process of searching for a perfect state of harmony. In this study, data approximation by a rational cubic Bézier function uses HS to optimize position of middle points and value of the weights. All the phases contribute significantly in making our proposed technique automated. Graphical examples of several postoperative skulls are displayed to show the effectiveness of our proposed method.

  9. Identification of the srtC1 Transcription Start Site and Catalytically Essential Residues Required for Actinomyces oris T14V SrtC1 Activity

    DTIC Science & Technology

    2011-07-27

    al., 1999, 2002; Frankel et al., 2007), Cys 193 in SrtC1 from Streptococcus pneumoniae (Manzano et al., 2008) and Cys 219 in SrtC1 from Group B...Sortase mediated pilus fiber biogenesis in Streptococcus pneumoniae . Structure 16: 1838 1848. Manzano C, Izore T, Job V, Di Guilmi AM & Dessen A... Streptococcus (Cozzi et al., 2011) are critical for each of their corresponding sortase activities. When two other residues (Leu263 and Thr265) in this

  10. Application of polymethacrylate resin as stationary phase in liquid chromatography with UV detection for C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines.

    PubMed

    Ohta, Kazutoku; Towata, Atsuya; Ohashi, Masayoshi; Takeuchi, Toyohide

    2004-06-11

    The application of unfunctionized polymethacrylate resin (TSKgel G3000PWXL) as a stationary phase in liquid chromatography with UV detection for C1-C7 aliphatic monocarboxylic acids (formic acid, acetic acid, propionic acid, butyric acid, isovaleric acid, valeric acid, 3,3-dimethylbutyric acid, 4-methylvaleric acid, hexanoic acid, 2-methylhexanoic acid, 5-methylhexanoic acid and heptanoic acid) and C1-C7 aliphatic monoamines (methylamine, ethylamine, propylamine, isobutylamine, butylamine, isoamylamine, amylamine, 1,3-dimethylbutylamine, hexylamine, 2-heptylamine and heptylamine) was carried out. Using dilute sulfuric acid as the eluent, the TSKgel G3000PWXL, resin acted as an advanced stationary phase for these C1-C7 carboxylic acids. Excellent simultaneous separation and symmetrical peaks for these C1-C7 carboxylic acids were achieved on a TSKgel G3000PWXL column (150 mm x 6 mm i.d.) in 60 min with 0.25 mM sulfuric acid containing 1 mM 2-methylheptanoic acid at pH 3.3 as the eluent. Using dilute sodium hydroxide as the eluent, the TSKgel G3000PWXL resin also behaved as an advanced stationary phase for these C1-C7 amines. Excellent simultaneous separation and good peaks for these C1-C7 amines were achieved on the TSKgel G3000PWXL column in 60 min with 10 mM sodium hydroxide containing 0.5 mM 1-methylheptylamine at pH 11.9 as the eluent.

  11. Biodegradation and adsorption of C1- and C2-phenanthrenes and C1- and C2-dibenzothiophenes in the presence of clay minerals: effect on forensic diagnostic ratios.

    PubMed

    Ugochukwu, Uzochukwu C; Head, Ian M; Manning, David A C

    2014-07-01

    The impact of modified montmorillonites on adsorption and biodegradation of crude oil C1-phenanthrenes, C1-dibenzothiophenes, C2-phenanthrenes and C2-dibenzothiophenes was investigated in aqueous clay/oil microcosm experiments with a hydrocarbon degrading microorganism community. Consequently, the effect on C1-dibenzothiophenes/C1-phenanthrenes, C2-dibenzothiophenes/C2-phenanthrenes, 2+3-methyldibenzothiophene/4-methyldibenzothiophene and 1-methyldibenzothiophene/4-methyldibenzothiophene ratios commonly used as diagnostic ratios for oil forensic studies was evaluated. The clay mineral samples were treated to produce acid activated montmorillonite, organomontmorillonite and homoionic montmorillonite which were used in this study. The different clay minerals (modified and unmodified) showed varied degrees of biodegradation and adsorption of the C1-phenanthrenes, C1-dibenzothiophenes, C2-phenanthrenes and C2-dibenzothiophenes. The study indicated that as opposed to biodegradation, adsorption has no effect on the diagnostic ratios. Among the diagnostic ratios reviewed, only C2-dibenzothiophenes/C2-phenanthrenes ratio was neither affected by adsorption nor biodegradation making this ratio very useful in forensic studies of oil spills and oil-oil correlation.

  12. Serum C1q as a novel biomarker of sarcopenia in older adults.

    PubMed

    Watanabe, Shinya; Sato, Koji; Hasegawa, Natsuki; Kurihara, Toshiyuki; Matsutani, Kenji; Sanada, Kiyoshi; Hamaoka, Takafumi; Fujita, Satoshi; Iemitsu, Motoyuki

    2015-03-01

    Aging-induced elevation in C1q secretion activates the Wnt signaling pathway in muscles, leading to the development of muscle fibrosis. However, the association between serum C1q level and muscle mass and strength remains unclear in humans. The aim of the study was to elucidate whether serum C1q level is associated with aging- and resistance training-induced changes in muscle mass and strength. First, in a cross-sectional study, we investigated the association between serum C1q level and muscle mass and strength in 131 healthy subjects, aged 20-81 yr. Second, in an intervention study, we examined the association between the effects of serum C1q level and muscle mass and strength on 12 wk resistance training in 11 healthy older adults (60-81 yr). In the cross-sectional study, serum C1q level increased with aging and was negatively correlated with muscle mass and strength. Furthermore, 12 wk resistance training in older adults reduced the age-associated elevation in serum C1q levels. The training effect of serum C1q level significantly correlated with the change in the cross-sectional area of the thigh (r = -0.703; P < 0.01). Serum C1q level may reflect loss of muscle mass; therefore, C1q may be a novel biomarker of sarcopenia.

  13. Functional characterization of βC1 gene of Cotton leaf curl Multan betasatellite.

    PubMed

    Tiwari, Neha; Sharma, P K; Malathi, V G

    2013-02-01

    Whitefly-transmitted Begomoviruses having circular single stranded DNA genome cause severe leaf curl diseases in the tropical and subtropical region. The majority of Old World monopartite begomoviruses with DNA A component is associated with a satellite DNA of 1.3 kb length referred to as betasatellites. The presence of betasatellite is required to express typical symptoms in the primary hosts. Increased symptom expression in betasatellite's presence is attributed to a 13-15 kDa βC1 protein encoded by the βC1 gene on complementary sense strand. The exact mechanism by which the βC1 protein contributes to the symptoms' severity and helper viral DNA's accumulation is not yet understood. Here, we studied the βC1 protein of Cotton leaf curl Multan betasatellite, associated with mono and bipartite begomoviruses. The βC1 protein was expressed in prokaryotic system as 6XHis-βC1 fusion protein and recombinant protein showed size- and sequence-specific DNA binding activity. The host proteins which may interact with βC1 were identified by binding βC1 recombinant protein with heptapeptide in phage display library. The βC1-interacting host proteins predicted belong to metabolic and defense pathways, indicating that βC1 protein has a pivotal role in viral pathogenicity.

  14. XPB Induces C1D Expression to Counteract UV-Induced Apoptosis

    PubMed Central

    Li, Guang; Liu, Juhong; Abu-Asab, Mones; Masabumi, Shibuya; Maru, Yoshiro

    2010-01-01

    Although C1D has been shown to be involved in DNA double-strand breaks repair, how C1D expression was induced and the mechanism(s) by which C1D facilitates DNA repair in mammalian cells remain poorly understood. We and others have previously shown that expression of XPB protein efficiently compensated the UV-irradiation sensitive phenotype of 27-1 cells which lacks functional XPB. To further explore XPB-regulated genes that could be involved in UV-induced DNA repair, Differential Display analysis of mRNA level from CHO-9, 27-1 and 27-1 complemented with wild-type XPB were performed and C1D gene was identified as one of the major genes whose expression was significantly up-regulated by restoring XPB function. We found that XPB is essential to induce C1D transcription after UV-irradiation. The increase of C1D expression effectively compensates the UV-induced proteolysis of C1D and thus maintains cellular C1D level to cope with DNA damage inflicted by UV-irradiation. We further showed that although insufficient to rescue 27-1 cells from UV-induced apoptosis by itself, C1D facilitates XPB DNA repair through direct interaction with XPB. Our findings provided direct evidence that C1D is associated with DNA repair complex and may promote repair of UV-induced DNA damage. PMID:20530579

  15. C1 CHEMISTRY FOR THE PRODUCTION OF ULTRA-CLEAN LIQUID TRANSPORTATION FUELS AND HYDROGEN

    SciTech Connect

    Gerald P. Huffman

    2003-09-30

    The Consortium for Fossil Fuel Science (CFFS) is a research consortium with participants from the University of Kentucky, University of Pittsburgh, University of Utah, West Virginia University, and Auburn University. The CFFS is conducting a research program to develop C1 chemistry technology for the production of clean transportation fuel from resources such as coal and natural gas, which are more plentiful domestically than petroleum. The processes under development will convert feedstocks containing one carbon atom per molecular unit into ultra clean liquid transportation fuels (gasoline, diesel, and jet fuel) and hydrogen, which many believe will be the transportation fuel of the future. These feedstocks include synthesis gas, a mixture of carbon monoxide and hydrogen produced by coal gasification or reforming of natural gas, methane, methanol, carbon dioxide, and carbon monoxide. Some highlights of the results obtained during the first year of the current research contract are summarized as: (1) Terminal alkynes are an effective chain initiator for Fischer-Tropsch (FT) reactions, producing normal paraffins with C numbers {ge} to that of the added alkyne. (2) Significant improvement in the product distribution towards heavier hydrocarbons (C{sub 5} to C{sub 19}) was achieved in supercritical fluid (SCF) FT reactions compared to that of gas-phase reactions. (3) Xerogel and aerogel silica supported cobalt catalysts were successfully employed for FT synthesis. Selectivity for diesel range products increased with increasing Co content. (4) Silicoaluminophosphate (SAPO) molecular sieve catalysts have been developed for methanol to olefin conversion, producing value-added products such as ethylene and propylene. (5) Hybrid Pt-promoted tungstated and sulfated zirconia catalysts are very effective in cracking n-C{sub 36} to jet and diesel fuel; these catalysts will be tested for cracking of FT wax. (6) Methane, ethane, and propane are readily decomposed to pure

  16. C1 Chemistry for the Production of Ultra-Clean Liquid Transportation Fuels and Hydrogen

    SciTech Connect

    Gerald P. Huffman

    2006-03-30

    Professors and graduate students from five universities--the University of Kentucky, University of Pittsburgh, University of Utah, West Virginia University, and Auburn University--are collaborating in a research program to develop C1 chemistry processes to produce ultra-clean liquid transportation fuels and hydrogen, the zero-emissions transportation fuel of the future. The feedstocks contain one carbon atom per molecular unit. They include synthesis gas (syngas), a mixture of carbon monoxide and hydrogen produced by coal gasification or reforming of natural gas, methane, methanol, carbon dioxide, and carbon monoxide. An important objective is to develop C1 technology for the production of liquid transportation fuel and hydrogen from domestically plentiful resources such as coal, coalbed methane, and hydrocarbon gases and liquids produced from coal. An Advisory Board with representatives from Chevron-Texaco, Eastman Chemical, Conoco-Phillips, the Air Force Research Laboratory, the U.S. Army National Automotive Center, and Tier Associates provides guidance on the practicality of the research. The current report summarizes the results obtained in this program during the period October 1, 2002 through March 31, 2006. The results are presented in detailed reports on 16 research projects headed by professors at each of the five CFFS Universities and an Executive Summary. Some of the highlights from these results are: (1) Small ({approx}1%) additions of acetylene or other alkynes to the Fischer-Tropsch (F-T) reaction increases its yield, causes chain initiation, and promotes oxygenate formation. (2) The addition of Mo to Fe-Cu-K/AC F-T catalysts improves catalyst lifetime and activity. (3) The use of gas phase deposition to place highly dispersed metal catalysts on silica or ceria aerogels offers promise for both the F-T and the water-gas shift WGS reactions. (4) Improved activity and selectivity are exhibited by Co F-T catalysts in supercritical hexane. (5) Binary Fe

  17. Cell Surface Expression and Function of the Macromolecular C1 Complex on the Surface of Human Monocytes

    PubMed Central

    Hosszu, Kinga K.; Valentino, Alisa; Ji, Yan; Matkovic, Mara; Pednekar, Lina; Rehage, Nina; Tumma, Nithin; Peerschke, Ellinor I. B.; Ghebrehiwet, Berhane

    2011-01-01

    The synthesis of the subunits of the C1 complex (C1q, C1s, C1r), and its regulator C1 inhibitor (C1-Inh) by human monocytes has been previously established. However, surface expression of these molecules by monocytes has not been shown. Using flow cytometry and antigen-capture enzyme-linked immunosorbent assay, we show here for the first time that, in addition to C1q, peripheral blood monocytes, and the monocyte-derived U937 cells express C1s and C1r, as well as Factor B and C1-Inh on their surface. C1s and C1r immunoprecipitated with C1q, suggesting that at least some of the C1q on these cells is part of the C1 complex. Furthermore, the C1 complex on U937 cells was able to trigger complement activation via the classical pathway. The presence of C1-Inh may ensure that an unwarranted autoactivation of the C1 complex does not take place. Since C1-Inh closely monitors the activation of the C1 complex in a sterile or infectious inflammatory environment, further elucidation of the role of C1 complex is crucial to dissect its function in monocyte, dendritic cell, and T cell activities, and its implications in host defense and tolerance. PMID:22566921

  18. Occurrence and Antioxidant Activity of C1 Degradation Products in Cocoa

    PubMed Central

    De Taeye, Cédric; Kankolongo Cibaka, Marie-Lucie; Collin, Sonia

    2017-01-01

    Procyanidin C1 is by far the main flavan-3-ol trimer in cocoa. Like other flavan-3-ols, however, it suffers a lot during heat treatments such as roasting. RP-HPLC-HRMS/MS(ESI(−))analysis applied to an aqueous model medium containing commercial procyanidin C1 proved that epimerization is the main reaction involved in its degradation (accounting for 62% of degradation products). In addition to depolymerization, cocoa procyanidin C1 also proved sensitive to oxidation, yielding once- and twice-oxidized dimers. No chemical oligomer involving the native trimer was found in either model medium or cocoa, while two C1 isomers were retrieved. C1 degradation products exhibited antioxidant activity (monitored by RP-HPLC-Online TEAC) close to that of C1 (when expressed in µM TE/mg·kg−1). PMID:28264525

  19. The C1q complement family of synaptic organizers: not just complementary.

    PubMed

    Yuzaki, Michisuke

    2017-02-17

    Molecules that regulate formation, differentiation, and maintenance of synapses are called synaptic organizers. Recently, various 'C1q family' proteins have been shown to be released from neurons, and serve as a new class of synaptic organizers. Cbln1 and C1ql1 proteins regulate the formation and maintenance of parallel fiber-Purkinje cell and climbing fiber-Purkinje cell synapses, respectively, in the cerebellum. Cbln1 also modulates the function of postsynaptic delta2 glutamate receptors to regulate synaptic plasticity. C1ql2 and C1ql3, released from mossy fibers, determine the synaptic localization of postsynaptic kainate receptors in the hippocampus. C1ql3 also regulates the formation of synapses between the basolateral amygdala and the prefrontal cortex. These findings indicate the diverse functions of C1q family proteins in various brain regions.

  20. Effects of C1 Inhibitor on Tissue Damage in a Porcine Model of Controlled Hemorrhage

    DTIC Science & Technology

    2012-07-01

    glucose, hematocrit (Hct), hemoglobin ( Hb ), sodium (Na+), potassium (K+), and ionized calcium (Ca2+) using i STAT cartridges (Abbott Laboratories, Abbott...Shock Society. Unauthorized reproduction of this article is prohibited. (Princeton, NJ). MicroVue C1 INH enzyme immunoassay (EIA) kit was purchased from...TABLE 3. Prehemorrhage and posthemorrhage metabolic data of hemorrhaged animals Group PSham H H + C1-100 H + C1-250 n 5 5 6 4 5 4 5 Prehemorrhage Hb , g

  1. 29 CFR 2550.404c-1 - ERISA section 404(c) plans.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false ERISA section 404(c) plans. 2550.404c-1 Section 2550.404c-1... REGULATIONS FOR FIDUCIARY RESPONSIBILITY § 2550.404c-1 ERISA section 404(c) plans. (a) In general. (1) Section 404(c) of the Employee Retirement Income Security Act of 1974 (ERISA or the Act) provides that if...

  2. 29 CFR 2550.404c-1 - ERISA section 404(c) plans.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false ERISA section 404(c) plans. 2550.404c-1 Section 2550.404c-1... REGULATIONS FOR FIDUCIARY RESPONSIBILITY § 2550.404c-1 ERISA section 404(c) plans. (a) In general. (1) Section 404(c) of the Employee Retirement Income Security Act of 1974 (ERISA or the Act) provides that if...

  3. Inhibition of the activation of Hageman factor (factor XII) by complement subcomponent C1q.

    PubMed

    Rehmus, E H; Greene, B M; Everson, B A; Ratnoff, O D

    1987-08-01

    Hageman factor (HF, Factor XII) is activated by glass, collagen, and ellagic acid, and initiates blood coagulation via the intrinsic pathway. C1q inhibits collagen-induced platelet aggregation and adherence of platelets to glass, effects attributable to the collagen-like region of C1q. We examined the actions of C1q on HF activation. Incubation of C1q with HF before addition of HF-deficient plasma extended the activated partial thromboplastin time. Similarly, when glass tubes were coated with C1q before testing, the partial thromboplastin time of normal plasma was increased. C1q reduced the activation of HF by ellagic acid, as measured by the release of p-nitroaniline from the synthetic substrate H-D-prolyl-L-phenylalanyl-L-arginine-p-nitroanilide dihydrochloride, an effect inhibited by monoclonal anti-human C1q murine IgG and by digestion of C1q by collagenase. Thus, C1q inhibits activation of HF in vitro in clot-promoting and amidolytic assays and suggests a regulatory mechanism for the inhibition of coagulation.

  4. Inhibition of the activation of Hageman factor (factor XII) by complement subcomponent C1q.

    PubMed Central

    Rehmus, E H; Greene, B M; Everson, B A; Ratnoff, O D

    1987-01-01

    Hageman factor (HF, Factor XII) is activated by glass, collagen, and ellagic acid, and initiates blood coagulation via the intrinsic pathway. C1q inhibits collagen-induced platelet aggregation and adherence of platelets to glass, effects attributable to the collagen-like region of C1q. We examined the actions of C1q on HF activation. Incubation of C1q with HF before addition of HF-deficient plasma extended the activated partial thromboplastin time. Similarly, when glass tubes were coated with C1q before testing, the partial thromboplastin time of normal plasma was increased. C1q reduced the activation of HF by ellagic acid, as measured by the release of p-nitroaniline from the synthetic substrate H-D-prolyl-L-phenylalanyl-L-arginine-p-nitroanilide dihydrochloride, an effect inhibited by monoclonal anti-human C1q murine IgG and by digestion of C1q by collagenase. Thus, C1q inhibits activation of HF in vitro in clot-promoting and amidolytic assays and suggests a regulatory mechanism for the inhibition of coagulation. PMID:3038961

  5. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery.

    PubMed

    Vazquez-Cintron, Edwin J; Beske, Phillip H; Tenezaca, Luis; Tran, Bao Q; Oyler, Jonathan M; Glotfelty, Elliot J; Angeles, Christopher A; Syngkon, Aurelia; Mukherjee, Jean; Kalb, Suzanne R; Band, Philip A; McNutt, Patrick M; Shoemaker, Charles B; Ichtchenko, Konstantin

    2017-02-21

    Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a molecular vehicle capable of delivering therapeutic cargo into the neuronal cytosol. Building upon previous work, we have developed an atoxic derivative (ad) of BoNT/C1 through rationally designed amino acid substitutions in the metalloprotease domain of wild type (wt) BoNT/C1. To test if BoNT/C1 ad retains neuron-specific targeting without concomitant toxic host responses, we evaluated the localization, activity, and toxicity of BoNT/C1 ad in vitro and in vivo. In neuronal cultures, BoNT/C1 ad light chain is rapidly internalized into presynaptic compartments, but does not cleave SNARE proteins nor impair spontaneous neurotransmitter release. In mice, systemic administration resulted in the specific co-localization of BoNT/C1 ad with diaphragmatic motor nerve terminals. The mouse LD50 of BoNT/C1 ad is 5 mg/kg, with transient neurological symptoms emerging at sub-lethal doses. Given the low toxicity and highly specific neuron-targeting properties of BoNT/C1 ad, these data suggest that BoNT/C1 ad can be useful as a molecular vehicle for drug delivery to the neuronal cytoplasm.

  6. Overview of hereditary angioedema caused by C1-inhibitor deficiency: assessment and clinical management.

    PubMed

    Bork, K; Davis-Lorton, M

    2013-02-01

    Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH) is a rare, autosomal-dominant disease. HAE-C1-INH is characterized by recurrent attacks of marked, diffuse, nonpitting and nonpruritic skin swellings, painful abdominal attacks, and laryngeal edema. The extremities and the gastrointestinal tract are most commonly affected. Swelling of the upper respiratory mucosa poses the greatest risk because death from asphyxiation can result from laryngealedema. HAE-C1-INH attacks are variable, unpredictable, and may be induced by a variety of stimuli, including stress or physical trauma. Because the clinical presentation of HAE-C1-INH is similar to other types of angioedema, the condition may be a challenge to diagnose. Accurate identification of HAE-C1-INH is critical in order to avoid asphyxiation by laryngeal edema and to improve the burden of disease. Based on an understanding of the underlying pathophysiology of IHAE-C1-INH, drugs targeted specifically to the disease, such as C1-inhibitor therapy, bradykinin B2-receptor antagonists, and kallikrein-inhibitors, have become available for both treatment and prevention of angioedema attacks. This article reviews the clinical features, differential diagnosis, and current approaches to management of HAE-C1-INH.

  7. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

    PubMed Central

    Vazquez-Cintron, Edwin J.; Beske, Phillip H.; Tenezaca, Luis; Tran, Bao Q.; Oyler, Jonathan M.; Glotfelty, Elliot J.; Angeles, Christopher A.; Syngkon, Aurelia; Mukherjee, Jean; Kalb, Suzanne R.; Band, Philip A.; McNutt, Patrick M.; Shoemaker, Charles B.; Ichtchenko, Konstantin

    2017-01-01

    Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a molecular vehicle capable of delivering therapeutic cargo into the neuronal cytosol. Building upon previous work, we have developed an atoxic derivative (ad) of BoNT/C1 through rationally designed amino acid substitutions in the metalloprotease domain of wild type (wt) BoNT/C1. To test if BoNT/C1 ad retains neuron-specific targeting without concomitant toxic host responses, we evaluated the localization, activity, and toxicity of BoNT/C1 ad in vitro and in vivo. In neuronal cultures, BoNT/C1 ad light chain is rapidly internalized into presynaptic compartments, but does not cleave SNARE proteins nor impair spontaneous neurotransmitter release. In mice, systemic administration resulted in the specific co-localization of BoNT/C1 ad with diaphragmatic motor nerve terminals. The mouse LD50 of BoNT/C1 ad is 5 mg/kg, with transient neurological symptoms emerging at sub-lethal doses. Given the low toxicity and highly specific neuron-targeting properties of BoNT/C1 ad, these data suggest that BoNT/C1 ad can be useful as a molecular vehicle for drug delivery to the neuronal cytoplasm. PMID:28220863

  8. Anti-C1q Autoantibodies, Novel Tests, and Clinical Consequences

    PubMed Central

    Mahler, Michael; van Schaarenburg, Rosanne A.; Trouw, Leendert A.

    2013-01-01

    Although anti-C1q autoantibodies have been described more than four decades ago a constant stream of papers describing clinical associations or functional consequences highlights that anti-C1q antibodies are still hot and happening. By far the largest set of studies focus on anti-C1q antibodies is systemic lupus erythematosus (SLE). In SLE anti-C1q antibodies associate with involvement of lupus nephritis in such a way that in the absence of anti-C1q antibodies it is unlikely that a flare in nephritis will occur. Anti-C1q antibodies occur in several autoimmune conditions but also in healthy individuals. Although considerable progress has been made in the understanding of how anti-C1q antibodies may contribute to tissue injury there is still a lot to learn about the processes involved in the breaking of tolerance to this protein. There has been considerable improvement in the assays employed to test for the presence of anti-C1q antibodies. Hopefully with these new and standardized assays at hand larger clinical association studies will be conducted with independent replication. Such large-scale studies will reveal the true value of clinical testing for anti-C1q autoantibodies in several clinical conditions. PMID:23717311

  9. The Development, Diffusion and Evaluation of a Fall Hazard Safety Training Program for Residential Construction Workers Utilizing Instructor Led and New Media Delivery

    ERIC Educational Resources Information Center

    Fullen, Mark D.

    2009-01-01

    The numbers of workers in the residential construction industry are on the rise. Falls have continually been the largest contributor to residential construction worker deaths and injuries. These workers are largely self-employed or working for small companies. These individuals are difficult to reach through traditional methods. This research…

  10. The determination of neutron energy spectrum in reactor core C1 of reactor VR-1 Sparrow

    SciTech Connect

    Vins, M.

    2008-07-15

    This contribution overviews neutron spectrum measurement, which was done on training reactor VR-1 Sparrow with a new nuclear fuel. Former nuclear fuel IRT-3M was changed for current nuclear fuel IRT-4M with lower enrichment of 235U (enrichment was reduced from former 36% to 20%) in terms of Reduced Enrichment for Research and Test Reactors (RERTR) Program. Neutron spectrum measurement was obtained by irradiation of activation foils at the end of pipe of rabit system and consecutive deconvolution of obtained saturated activities. Deconvolution was performed by computer iterative code SAND-II with 620 groups' structure. All gamma measurements were performed on Canberra HPGe. Activation foils were chosen according physical and nuclear parameters from the set of certificated foils. The Resulting differential flux at the end of pipe of rabit system agreed well with typical spectrum of light water reactor. Measurement of neutron spectrum has brought better knowledge about new reactor core C1 and improved methodology of activation measurement. (author)

  11. An Investigation into Current Construction Engineering and Management Programs and Curricula and Their Applicability to the U.S. Armed Forces

    DTIC Science & Technology

    1988-06-01

    the need for graduate programs has flourished. And flourish the graduate programs have, gairing mzcre popularity and being offered at ever increasing...numbers of institutions. The top civil engineering departments have strong graduate programs in the area and several award more graduate degrees in...political, and technclogical aspects of the field. Graduate programs must also attempt to be the leading edge in technological research and exploration

  12. Electrochemical construction

    DOEpatents

    Einstein, Harry; Grimes, Patrick G.

    1983-08-23

    An electrochemical cell construction features a novel co-extruded plastic electrode in an interleaved construction with a novel integral separator-spacer. Also featured is a leak and impact resistant construction for preventing the spill of corrosive materials in the event of rupture.

  13. Functional C1q is present in the skin mucus of Siberian sturgeon (Acipenser baerii).

    PubMed

    Fan, Chunxin; Wang, Jian; Zhang, Xuguang; Song, Jiakun

    2015-01-01

    The skin mucus of fish acts as the first line of self-protection against pathogens in the aquatic environment and comprises a number of innate immune components. However, the presence of the critical classical complement component C1q, which links the innate and adaptive immune systems of mammalians, has not been explored in a primitive actinopterygian fish. In this study, we report that C1q is present in the skin mucus of the Siberian sturgeon (Acipenser baerii). The skin mucus was able to inhibit the growth of Escherichia coli. The bacteriostatic activity of the skin mucus was reduced by heating and by pre-incubation with EDTA or mouse anti-human C1q antibody. We also detected C1q protein in skin mucus using the western blot procedure and isolated a cDNA that encodes the Siberian sturgeon C1qC, which had 44.7-51.4% identity with C1qCs in teleosts and tetrapods. A phylogenetic analysis revealed that Siberian sturgeon C1qC lies at the root of the actinopterygian branch and is separate from the tetrapod branch. The C1qC transcript was expressed in many tissues as well as in skin. Our data indicate that C1q is present in the skin mucus of the Siberian sturgeon to protect against water-borne bacteria, and the C1qC found in the sturgeon may represent the primitive form of teleost and tetrapod C1qCs.

  14. Spinolaminar Line Test as a Screening Tool for C1 Stenosis

    PubMed Central

    Oshima, Yasushi; Kelly, Michael P.; Song, Kwang-Sup; Park, Moon Soo; Chuntarapas, Tapanut; Vo, Katie D.; Yeom, Jin S.; Takeshita, Katsushi; Riew, K. Daniel

    2015-01-01

    Study Design Retrospective cohort. Objective To clarify the sensitivity of C3–C2 spinolaminar line test as a screening tool for the stenosis of C1 space available for the cord (SAC). Methods Spine clinic records from April 2005 to August 2011 were reviewed. The C1 SAC was measured on lateral radiographs, and the relative positions between a C1 posterior arch and the C3–C2 spinolaminar line were examined and considered “positive” when the C1 ring lay ventral to the line. Computed tomography (CT) scans and magnetic resonance imaging (MRI) were utilized to measure precise diameters of C1 and C2 SAC and to check the existence of spinal cord compression. Results Four hundred eighty-seven patients were included in this study. There were 246 men and 241 women, with an average age of 53 years (range: 18 to 86). The mean SAC at C1 on radiographs was 21.2 mm (range: 13.5 to 28.2). Twenty-one patients (4.3%) were positive for the spinolaminar line test; all of these patients had C1 SAC of 19.4 mm or less. Eight patients (1.6%) had C1 SAC smaller than C2 on CT examination; all of these patients had a positive spinolaminar test, with high sensitivity (100%) and specificity (97%). MRI analysis revealed that two of the eight patients with a smaller C1 SAC had spinal cord compression at the C1 level. Conclusion Although spinal cord compression at the level of atlas without instability is a rare condition, the spinolaminar line can be used as a screening of C1 stenosis. PMID:27190740

  15. Characterisation of a C1qtnf5 Ser163Arg Knock-In Mouse Model of Late-Onset Retinal Macular Degeneration

    PubMed Central

    Shu, Xinhua; Luhmann, Ulrich F. O.; Aleman, Tomas S.; Barker, Susan E.; Lennon, Alan; Tulloch, Brian; Chen, Mei; Xu, Heping; Jacobson, Samuel G.; Ali, Robin; Wright, Alan F.

    2011-01-01

    A single founder mutation resulting in a Ser163Arg substitution in the C1QTNF5 gene product causes autosomal dominant late-onset retinal macular degeneration (L-ORMD) in humans, which has clinical and pathological features resembling age-related macular degeneration. We generated and characterised a mouse “knock-in” model carrying the Ser163Arg mutation in the orthologous murine C1qtnf5 gene by site-directed mutagenesis and homologous recombination into mouse embryonic stem cells. Biochemical, immunological, electron microscopic, fundus autofluorescence, electroretinography and laser photocoagulation analyses were used to characterise the mouse model. Heterozygous and homozygous knock-in mice showed no significant abnormality in any of the above measures at time points up to 2 years. This result contrasts with another C1qtnf5 Ser163Arg knock-in mouse which showed most of the features of L-ORMD but differed in genetic background and targeting construct. PMID:22110650

  16. Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration.

    PubMed

    Shu, Xinhua; Luhmann, Ulrich F O; Aleman, Tomas S; Barker, Susan E; Lennon, Alan; Tulloch, Brian; Chen, Mei; Xu, Heping; Jacobson, Samuel G; Ali, Robin; Wright, Alan F

    2011-01-01

    A single founder mutation resulting in a Ser163Arg substitution in the C1QTNF5 gene product causes autosomal dominant late-onset retinal macular degeneration (L-ORMD) in humans, which has clinical and pathological features resembling age-related macular degeneration. We generated and characterised a mouse "knock-in" model carrying the Ser163Arg mutation in the orthologous murine C1qtnf5 gene by site-directed mutagenesis and homologous recombination into mouse embryonic stem cells. Biochemical, immunological, electron microscopic, fundus autofluorescence, electroretinography and laser photocoagulation analyses were used to characterise the mouse model. Heterozygous and homozygous knock-in mice showed no significant abnormality in any of the above measures at time points up to 2 years. This result contrasts with another C1qtnf5 Ser163Arg knock-in mouse which showed most of the features of L-ORMD but differed in genetic background and targeting construct.

  17. Enhanced synaptic connectivity and epilepsy in C1q knockout mice.

    PubMed

    Chu, Yunxiang; Jin, Xiaoming; Parada, Isabel; Pesic, Alexei; Stevens, Beth; Barres, Ben; Prince, David A

    2010-04-27

    Excessive CNS synapses are eliminated during development to establish mature patterns of neuronal connectivity. A complement cascade protein, C1q, is involved in this process. Mice deficient in C1q fail to refine retinogeniculate connections resulting in excessive retinal innervation of lateral geniculate neurons. We hypothesized that C1q knockout (KO) mice would exhibit defects in neocortical synapse elimination resulting in enhanced excitatory synaptic connectivity and epileptiform activity. We recorded spontaneous and evoked field potential activity in neocortical slices and obtained video-EEG recordings from implanted C1q KO and wild-type (WT) mice. We also used laser scanning photostimulation of caged glutamate and whole cell recordings to map excitatory and inhibitory synaptic connectivity. Spontaneous and evoked epileptiform field potentials occurred at multiple sites in neocortical slices from C1q KO, but not WT mice. Laser mapping experiments in C1q KO slices showed that the proportion of glutamate uncaging sites from which excitatory postsynaptic currents (EPSCs) could be evoked ("hotspot ratio") increased significantly in layer IV and layer V, although EPSC amplitudes were unaltered. Density of axonal boutons was significantly increased in layer V pyramidal neurons of C1q KO mice. Implanted KO mice had frequent behavioral seizures consisting of behavioral arrest associated with bihemispheric spikes and slow wave activity lasting from 5 to 30 s. Results indicate that epileptogenesis in C1q KO mice is related to a genetically determined failure to prune excessive excitatory synapses during development.

  18. 26 CFR 1.641(c)-1 - Electing small business trust.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Electing small business trust. 1.641(c)-1...) INCOME TAX (CONTINUED) INCOME TAXES Estates, Trusts, and Beneficiaries § 1.641(c)-1 Electing small business trust. (a) In general. An electing small business trust (ESBT) within the meaning of section...

  19. Relevance of anti-C1q autoantibodies to lupus nephritis.

    PubMed

    Tsirogianni, Alexandra; Pipi, Elena; Soufleros, Kostantinos

    2009-09-01

    The first component of the classical pathway of the complement system (C1q) is considered to have a crucial role in the clearance of immune complexes (ICs) as well as in the removal of waste material originating from apoptotic cells. A prolonged exposure of C1q epitopes to the immune system could eventually lead to an autoimmune response against itself. Although autoantibodies against C1q are found in several diseases, their clinical interest originates from their strong association to active lupus nephritis (LN). Several studies indicate that anti-C1q autoantibodies could serve as a reliable serologic marker in the assessment of LN activity compared to other immunological tests. Additionally, it was suggested that anti-C1q autoantibodies could play a role in LN pathogenesis. Their potential pathogenic actions likely depend on genetic background, titers, Ig classes and subclasses, and specific epitopes of anti-C1q autoantibodies as well as C1q availability and allocation. It is still unclear which different types of anti-C1q autoantibodies dominate in each case and if their upregulation is pathogenic, an epiphenomenon of aberrant tissue damage, or compensatory to an uncontrolled immune response.

  20. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or...

  1. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or...

  2. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or...

  3. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or...

  4. 17 CFR 240.15c1-9 - Use of pro forma balance sheets.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Use of pro forma balance sheets. 240.15c1-9 Section 240.15c1-9 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... pro forma balance sheets. The term manipulative, deceptive, or other fraudulent device or...

  5. 26 CFR 1.280C-1 - Disallowance of certain deductions for wage or salary expenses.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... salary expenses. 1.280C-1 Section 1.280C-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Disallowance of certain deductions for wage or salary expenses. If an employer elects to claim the targeted... reduce its deduction for wage or salary expenses paid or incurred in the year the credit is earned by...

  6. 26 CFR 1.280C-1 - Disallowance of certain deductions for wage or salary expenses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... salary expenses. 1.280C-1 Section 1.280C-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... certain deductions for wage or salary expenses. If an employer elects to claim the targeted jobs credit... deduction for wage or salary expenses paid or incurred in the year the credit is earned by the...

  7. 26 CFR 1.280C-1 - Disallowance of certain deductions for wage or salary expenses.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... salary expenses. 1.280C-1 Section 1.280C-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Disallowance of certain deductions for wage or salary expenses. If an employer elects to claim the targeted... reduce its deduction for wage or salary expenses paid or incurred in the year the credit is earned by...

  8. 26 CFR 1.280C-1 - Disallowance of certain deductions for wage or salary expenses.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... salary expenses. 1.280C-1 Section 1.280C-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Disallowance of certain deductions for wage or salary expenses. If an employer elects to claim the targeted... reduce its deduction for wage or salary expenses paid or incurred in the year the credit is earned by...

  9. 26 CFR 1.280C-1 - Disallowance of certain deductions for wage or salary expenses.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... salary expenses. 1.280C-1 Section 1.280C-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... Disallowance of certain deductions for wage or salary expenses. If an employer elects to claim the targeted... reduce its deduction for wage or salary expenses paid or incurred in the year the credit is earned by...

  10. 26 CFR 301.6104(c)-1 - Disclosure of certain information to State officers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Disclosure of certain information to State officers. 301.6104(c)-1 Section 301.6104(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE...) of this section, the Internal Revenue Service will notify the Attorney General and the principal...

  11. Generalized van der Waals Hamiltonian: periodic orbits and C1 nonintegrability.

    PubMed

    Guirao, Juan L G; Llibre, Jaume; Vera, Juan A

    2012-03-01

    The aim of this paper is to study the periodic orbits of the generalized van der Waals Hamiltonian system. The tool for studying such periodic orbits is the averaging theory. Moreover, for this Hamiltonian system we provide information on its C(1) nonintegrability, i.e., on the existence of a second first integral of class C(1).

  12. 26 CFR 1.512(c)-1 - Special rules applicable to partnerships; in general.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Special rules applicable to partnerships; in general. 1.512(c)-1 Section 1.512(c)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Taxation of Business Income of...

  13. 26 CFR 31.3406(c)-1 - Notified payee underreporting of reportable interest or dividend payments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Notified payee underreporting of reportable interest or dividend payments. 31.3406(c)-1 Section 31.3406(c)-1 Internal Revenue INTERNAL REVENUE SERVICE...)(2)) made with respect to an account of a payee if the Internal Revenue Service or a broker...

  14. 26 CFR 1.641(c)-1 - Electing small business trust.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Electing small business trust. 1.641(c)-1... small business trust. (a) In general. An electing small business trust (ESBT) within the meaning of... meaning of section 642(c)(1). The limitations of section 681, regarding unrelated business income,...

  15. 26 CFR 1.641(c)-1 - Electing small business trust.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Electing small business trust. 1.641(c)-1... small business trust. (a) In general. An electing small business trust (ESBT) within the meaning of... meaning of section 642(c)(1). The limitations of section 681, regarding unrelated business income,...

  16. MECHANISMS OF ACTIVATION OF C'1 ESTERASE IN HEREDITARY ANGIONEUROTIC EDEMA PLASMA IN VITRO

    PubMed Central

    Donaldson, Virginia H.

    1968-01-01

    The generation of C'1 esterase activity in siliconed plasma obtained from individuals with hereditary angioneurotic edema in remission tends to occur spontaneously, but can be hastened during its incubation with preparations of activated Hageman factor. This effect of activated Hageman factor could not be shown during its incubation with normal siliconed plasma, nor could consumption of normal serum inhibition of C'1 esterase be clearly shown. Soy bean trypsin inhibitor and heparin could impair this enhanced generation of C'1 esterase but neither inhibits the esterolytic function of C'1 esterase once formed. Trasylol was less effective in blocking this effect of activated Hageman factor. While the mechanism of the effect of activated Hageman factor upon C'1 activation remains obscure, it is apparent that some intermediate steps, possibly involving a kinin-forming system of plasma, may play a role. PMID:5299945

  17. Recombinant replacement therapy for hereditary angioedema due to C1 inhibitor deficiency.

    PubMed

    Moldovan, Dumitru; Bernstein, Jonathan A; Cicardi, Marco

    2015-01-01

    Hereditary angioedema is a rare genetic condition transmitted as an autosomal dominant trait and characterized most commonly by the production of either inadequate or nonfunctioning C1 esterase inhibitor (C1-INH), a blood protein that regulates proteases in the complement, fibrinolytic and contact systems. Patients with hereditary angioedema suffer from episodic, unpredictable manifestations of edema affecting multiple anatomical locations, including the GI tract, facial tissue, the upper airway, oropharynx, urogenital region and/or the arms and legs. A rational approach to treatment is replacement of C1-INH protein, to normalize the levels of C1-INH activity and halt the progression of the biochemical activation processes underlying the edema formation. Ruconest is a highly purified recombinant human C1-INH. This article will focus on the results of ten clinical studies demonstrating the efficacy and safety of Ruconest(®) (Pharming Group NV, Leiden, the Netherlands), which is now approved for use in Europe, Israel and the USA.

  18. C2 laminar screw and C1-2 transarticular screw combined with C1 laminar hooks for atlantoaxial instability with unilateral vertebral artery injury.

    PubMed

    Guo, Qunfeng; Liu, Jun; Ni, Bin; Lu, Xuhua; Zhou, Fengjin

    2011-09-01

    Transarticular screw fixation (TASF) is technically demanding, with high risk of vertebral artery (VA) injury. How to manage intraoperative VA injury and choose optimal alternative fixation becomes a concern of spinal surgeons. In this study, the management strategy for a patient with suspected intraoperative VA injury was analyzed. A 53-year-old woman developed type II odontoid fracture and brain stem injury due to a motor vehicle accident 3 months earlier. After conservative treatments, the brain stem injury improved, but with residual ocular motility defect in the right eye. The odontoid fracture did not achieve fusion with displacement and absorption of fracture fragments. After admission, atlantoaxial fixation using bilateral C1-2 transarticular screws (TASs) combined with C1 laminar hooks was planed. The first TAS was inserted successfully. Unfortunately, suspected VA injury developed during tapping the tract for the second TAS. Considering the previous brain stem injury and that directly inserting the screw to tamponade the hemorrhage might cause VA stenosis or occlusion, we blocked the screw trajectory with bone wax. C2 laminar screw was implanted instead of intended TAS on the injured side. The management strategy for suspected VA injury should depend on intraoperative circumstances and be tailored to patients. Blocking screw trajectory with bone wax is a useful method to stop bleeding. Atlantoaxial fixation using C2 laminar screw and C1-2 TAS combined with C1 laminar hooks is an ideal alternative procedure.

  19. Separation and conductimetric detection of C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines on unfunctionized polymethacrylate resin columns.

    PubMed

    Ohta, Kazutoku; Towata, Atsuya; Ohashi, Masayoshi; Takeuchi, Toyohide

    2004-06-11

    The application of unfunctionized polymethacrylate resin (TSKgel G3000PWXL) as a stationary phase in liquid chromatography with conductimetric detection for C1-C7 aliphatic monocarboxylic acids (formic acid, acetic acid, propionic acid, butyric acid, isovaleric acid, valeric acid, 3,3-dimethylbutyric acid, 4-methylvaleric acid, hexanoic acid, 2-methylhexanoic acid, 5-methylhexanoic acid and heptanoic acid) and C1-C7 aliphatic monoamines (methylamine, ethylamine, propylamine, isobutylamine, butylamine, isoamylamine, amylamine, 1,3-dimethylbutylamine, hexylamine, 2-heptylamine and heptylamine) was attempted with C8 aliphatic monocarboxylic acids (2-propylvaleric acid, 2-ethylhexanoic acid, 2-methylheptanoic acid and octanoic acid) and C8 aliphatic monoamines (1,5-dimethylhexylamine, 2-ethylhexylamine, 1-methylheptylamine and octylamine) as eluents, respectively. Using 1 mM 2-methylheptanoic acid at pH 4.0 as the eluent, excellent separation and relatively high sensitive detection for these C1-C7 carboxylic acids were achieved on a TSKgel G3000PWXL column (150 mm x 6 mm i.d.) in 60 min. Using 2 mM octylamine at pH 11.0 as the eluent, excellent separation and relatively high sensitive detection for these C1-C7 amines were also achieved on the TSKgel G3000PWXL column in 60 min.

  20. Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment.

    PubMed

    Zeerleder, Sacha; Levi, Marcel

    2016-01-01

    Uncontrolled generation of bradykinin (BK) due to insufficient levels of protease inhibitors controlling contact phase (CP) activation, increased activity of CP proteins, and/or inadequate degradation of BK into inactive peptides increases vascular permeability via BK-receptor 2 (BKR2) and results in subcutaneous and submucosal edema formation. Hereditary and acquired angioedema due to C1-inhibitor deficiency (C1-INH-HAE and -AAE) are diseases characterized by serious and potentially fatal attacks of subcutaneous and submucosal edemas of upper airways, facial structures, abdomen, and extremities, due to inadequate control of BK generation. A decreased activity of C1-inhibitor is the hallmark of C1-INH-HAE (types 1 and 2) due to a mutation in the C1-inhibitor gene, whereas the deficiency in C1-inhibitor in C1-INH-AAE is the result of autoimmune phenomena. In HAE with normal C1-inhibitor, a significant percentage of patients have an increased activity of factor XIIa due to a FXII mutation (FXII-HAE). Treatment of C1-inhibitor-dependent angioedema focuses on restoring control of BK generation by inhibition of CP proteases by correcting the balance between CP inhibitors and BK breakdown or by inhibition of BK-mediated effects at the BKR2 on endothelial cells. This review will address the pathophysiology, clinical picture, diagnosis and available treatment in C1-inhibitor-dependent angioedema focusing on BK-release and its regulation. Key Messages Inadequate control of bradykinin formation results in the formation of characteristic subcutaneous and submucosal edemas of the skin, upper airways, facial structures, abdomen and extremities as seen in hereditary and acquired C1-inhibitor-dependent angioedema. Diagnosis of hereditary and acquired C1-inhibitor-dependent angioedema may be troublesome as illustrated by the fact that there is a significant delay in diagnosis; a certain grade of suspicion is therefore crucial for quick diagnosis. Submucosal edema formation in

  1. Une epreuve orale de francais en fin d'etudes de gestion. Construction et implications pedagogiques (An Oral French Exam at the End of a Marketing Program. Construction and Pedagogical Implications).

    ERIC Educational Resources Information Center

    Crawshaw, Robert H.

    1984-01-01

    An oral language test administered at the end of a four-year program combining business administration and French is described. The test consists of the formal presentation of a report including numbers, graphics, and text, a discussion of a theoretical issue, and interview. (MSE)

  2. Library Services and Construction Amendments of 1970. Hearing Before the Select Subcommittee on Education...on H.R. 16365 and S. 3318, Bills to Extend, Consolidate and Improve Programs Under the Library Services and Construction Act.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    The Bills seek to lessen the administrative burden upon the States through reduction of the number of State plans, which must be submitted and approved annually, from five to one and to afford the States greater discretion in allocating funds to meet specific State needs by combining, within a single authorization, the programs formerly authorized…

  3. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1996-01-01

    Part of the Annual Commodities Review 1995. Production of construction aggregates such as crushed stone and construction sand and gravel showed a marginal increase in 1995. Most of the 1995 increases were due to funding for highway construction work. The major areas of concern to the industry included issues relating to wetlands classification and the classification of crystalline silica as a probable human carcinogen. Despite this, an increase in demand is anticipated for 1996.

  4. A New Protein Phosphatase 2C (FsPP2C1) Induced by Abscisic Acid Is Specifically Expressed in Dormant Beechnut Seeds1

    PubMed Central

    Lorenzo, Oscar; Rodríguez, Dolores; Nicolás, Gregorio; Rodríguez, Pedro L.; Nicolás, Carlos

    2001-01-01

    An abscisic acid (ABA)-induced cDNA fragment encoding a putative protein phosphatase 2C (PP2C) was obtained by means of differential reverse transcriptase-polymerase chain reaction approach. The full-length clone was isolated from a cDNA library constructed using mRNA from ABA-treated beechnut (Fagus sylvatica) seeds. This clone presents all the features of plant type PP2C and exhibits homology to members of this family such as AthPP2CA (61%), ABI1 (48%), or ABI2 (47%), therefore it was named FsPP2C1. The expression of FsPP2C1 is detected in dormant seeds and increases after ABA treatment, when seeds are maintained dormant, but it decreases and tends to disappear when dormancy is being released by stratification or under gibberellic acid treatment. Moreover, drought stress seems to have no effect on FsPP2C1 transcript accumulation. The FsPP2C1 transcript expression is tissue specific and was found to accumulate in ABA-treated seeds rather than in other ABA-treated vegetative tissues examined. These results suggest that the corresponding protein could be related to ABA-induced seed dormancy. By expressing FsPP2C1 in Escherichia coli as a histidine tag fusion protein, we have obtained direct biochemical evidence supporting Mg2+-dependent phosphatase activity of this protein. PMID:11299374

  5. Constructive Fun.

    ERIC Educational Resources Information Center

    Simanek, Donald E.

    1994-01-01

    Compares and reviews currently available brands of steel construction sets that are useful to physics teachers for building demonstrations, prototypes of mechanisms, robotics, and remote control devices. (ZWH)

  6. A PP2C-1 Allele Underlying a Quantitative Trait Locus Enhances Soybean 100-Seed Weight.

    PubMed

    Lu, Xiang; Xiong, Qing; Cheng, Tong; Li, Qing-Tian; Liu, Xin-Lei; Bi, Ying-Dong; Li, Wei; Zhang, Wan-Ke; Ma, Biao; Lai, Yong-Cai; Du, Wei-Guang; Man, Wei-Qun; Chen, Shou-Yi; Zhang, Jin-Song

    2017-03-28

    Cultivated soybeans may lose some useful genetic locus during domestication. Introgression of genes from wild soybeans may broaden the genetic background and improve soybean agronomic traits. Here, through whole-genome sequencing of an RIL population derived from a cross between a wild soybean ZYD7 and a cultivated soybean HN44, and mapping of QTLs for seed weight, we discover that a phosphatase 2C-1 (PP2C-1) allele from wild soybean ZYD7 contributes to the increase of seed weight/size in transgenic plants. The PP2C-1 may achieve this function by enhancing cell size of integument and activating a subset of seed trait-related genes. The PP2C-1 was further found to associate with a transcription factor GmBZR1 and facilitate accumulation of dephosphorylated GmBZR1. In contrast, a PP2C-2 allele with variations of a few amino acids at N-terminus does not exhibit this function. Moreover, the GmBZR1 can promote seed weight/size in transgenic plants. Through analysis of cultivated soybean accessions, we find that 40% of the examined accessions do not have the PP2C-1 allele, suggesting that these accessions can be improved through introduction of the PP2C-1 allele. Our study identifies an elite allele PP2C-1, which can enhance seed weight/size. Manipulation of the allele by molecule-assisted breeding may increase production in soybean and other legumes/crops.

  7. Amplitude analysis of the χc 1→η π+π- decays

    NASA Astrophysics Data System (ADS)

    Ablikim, M.; Achasov, M. N.; Ahmed, S.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Cheng, H. P.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; de Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Y.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, Lei; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Y. B.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J.; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Y. Y.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Long, Y. F.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Schumann, S.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Shi, M.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Z. Y.; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, W. L.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zallo, A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. N.; Zhang, Y. T.; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; Besiii Collaboration

    2017-02-01

    Using 448.0 ×1 06 ψ (3686 ) events collected with the BESIII detector, an amplitude analysis is performed for ψ (3686 )→γ χc 1 , χc 1→η π+π- decays. The most dominant two-body structure observed is a0(980 )±π∓ ; a0(980 )±→η π± . The a0(980 ) line shape is modeled using a dispersion relation, and a significant nonzero a0(980 ) coupling to the η'π channel is measured. We observe χc 1→a2(1700 )π production for the first time, with a significance larger than 17 σ . The production of mesons with exotic quantum numbers, JP C=1-+ , is investigated, and upper limits for the branching fractions χc 1→π1(1400 )±π∓ , χc 1→π1(1600 )±π∓ , and χc 1→π1(2015 )±π∓ , with subsequent π1(X )±→η π± decay, are determined.

  8. Atomic resolution model of the antibody Fc interaction with the complement C1q component.

    PubMed

    Schneider, Sebastian; Zacharias, Martin

    2012-05-01

    The globular C1q heterotrimer is a subunit of the C1 complement factor. Binding of the C1q subunit to the constant (Fc) part of antibody molecules is a first step and key event of complement activation. Although three-dimensional structures of C1q and antibody Fc subunits have been determined experimentally no atomic resolution structure of the C1q-Fc complex is known so far. Based on systematic protein-protein docking searches and Molecular Dynamics simulations a structural model of the C1q-IgG1-Fc-binding geometry has been obtained. The structural model is compatible with available experimental data on the interaction between the two partner proteins. It predicts a binding geometry that involves mainly the B-subunit of the C1q-trimer and both subunits of the IgG1-Fc-dimer with small conformational adjustments with respect to the unbound partners to achieve high surface complementarity. In addition to several charge-charge and polar contacts in the rim region of the interface it also involves nonpolar contacts between the two proteins and is compatible with the carbohydrate moiety of the Fc subunit. The model for the complex structure provides a working model for rationalizing available biochemical data on this important interaction and can form the basis for the design of Fc variants with a greater capacity to activate the complement system for example on binding to cancer cells or other target structures.

  9. Learning to Teach: Examining the Knowledge and Meanings Constructed by Novice Teachers within a Multi-Year, Standards-Based Induction and Mentoring Program

    ERIC Educational Resources Information Center

    Reid, Kimberly A.

    2010-01-01

    Mentoring and induction programs have moved to the forefront as a strategy for helping novice teachers adjust to the challenges of teaching and develop as effective educators. Induction and mentoring efforts may begin with helping new teachers become acclimated to the classroom and cope with immediate problems, but programs must also assist the…

  10. The Management Review and Analysis Program: An Assisted Self-Study to Secure Constructive Change in the Management of Research Libraries

    ERIC Educational Resources Information Center

    Webster, Duane E.

    1974-01-01

    The Management Review and Analysis Program, an assisted self-study strategy for large academic and research libraries, assists libraries in reviewing and analyzing their current management policies and practices, and provides guidelines for the application of contemporary principles of management for the improvement of library programs. (Author/LS)

  11. 40 CFR Appendix C-1 to Subpart E... - Required Provisions-Consulting Engineering Agreements

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... practicable, provide for maximum use of structures, machines, products, materials, construction methods, and... require the use of structures, machines, products, materials, construction methods, equipment, or... PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Grants for Construction...

  12. Aeroelastic Tests of an Eight Percent Scale Saturn C-1 Block II

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Aeroelastic Tests of an Eight Percent Scale Saturn C-1 Block II. Buffet and flutter characteristics of Saturn Apollo mission were studied using a dynamically scaled model. The model was built around a central aluminum tube for scaled stiffness distribution and strength to resist loads imposed during testing. Styrofoam sections attached to the core provided the correct external contours. Lead weights were added for correct mass distribution. An electromagnetic shaker was used to excite the model in its flexible modes of vibration during portions of the test. The model was supported on a sting, mounted by leaf springs, cables and torsion bars. The support system provided for simulating the full scale rigid body pitch frequency with minimum restraint imposed on elastic deflections. Bending moments recorded by sensors on the aluminum tube. Several modified nose configurations were tested: The basic configuration was tested with and without a flow separator disk on the escape rocket motor, tests also were made with the escape tower and rocket motor removed completely. For the final test, the Apollo capsule was replaced with a Jupiter nose cone. The test program consisted of determining model response throughout the transonic speed range at angles of attack up to 6 degrees and measuring the aerodynamic damping over the same range for the basic model and the modified configurations. Signals from the model pickup were recorded on tape for later analysis. The data obtained were used to estimate bending moments that would be produced on the full-scale vehicle by aerodynamic forces due to buffeting. [Entire movie available on DVD from CASI as Doc ID 20070030987. Contact help@sti.nasa.gov

  13. 77 FR 12106 - Kapka Butte Sno-Park Construction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ... Federal Highway Administration Kapka Butte Sno-Park Construction AGENCY: Western Federal Lands Highway... designation as Joint-Lead Agency for the Kapka Butte Sno-Park Construction project. SUMMARY: The FHWA is... pursuant to 23 U.S.C. 139(c)(1) for the Kapka Butte Sno-Park Construction project which is being studied...

  14. Dimension spectrum of asymptotically additive potentials for C1 average conformal repellers

    NASA Astrophysics Data System (ADS)

    Cao, Yongluo

    2013-09-01

    In this paper, the dimension spectrum of asymptotically additive potentials for C1 average conformal repellers is considered. First, we give dimension estimates of arbitrary subsets for C1 average conformal repellers and we also consider the pointwise dimension of invariant measures. Furthermore, we consider the dimension spectrum of asymptotically additive potentials and its properties. As applications, we give an affirmative answer to the problem posed by Olsen (2003 J. Math. Pures Appl. 82 1591-649) for general types of level sets and obtain the dimension spectrum of weak Gibbs measures for continuous potentials on C1 average conformal repellers.

  15. Population pharmacokinetics of recombinant human C1 inhibitor in patients with hereditary angioedema

    PubMed Central

    Farrell, Colm; Hayes, Siobhan; Relan, Anurag; van Amersfoort, Edwin S; Pijpstra, Rienk; Hack, C Erik

    2013-01-01

    Aims To characterize the pharmacokinetics (PK) of recombinant human C1 inhibitor (rhC1INH) in healthy volunteers and hereditary angioedema (HAE) patients. Methods Plasma levels of C1INH following 294 administrations of rhC1INH in 133 subjects were fitted using nonlinear mixed-effects modelling. The model was used to simulate maximal C1INH levels for the proposed dosing scheme. Results A one-compartment model with Michaelis–Menten elimination kinetics described the data. Baseline C1INH levels were 0.901 [95% confidence interval (CI): 0.839–0.968] and 0.176 U ml−1 (95% CI: 0.154–0.200) in healthy volunteers and HAE patients, respectively. The volume of distribution of rhC1INH was 2.86 l (95% CI: 2.68–3.03). The maximal rate of elimination and the concentration corresponding to half this maximal rate were 1.63 U ml−1 h−1 (95% CI: 1.41–1.88) and 1.60 U ml−1 (95% CI: 1.14–2.24), respectively, for healthy volunteers and symptomatic HAE patients. The maximal elimination rate was 36% lower in asymptomatic HAE patients. Peak C1INH levels did not change upon repeated administration of rhC1INH. Bodyweight was found to be an important predictor of the volume of distribution. Simulations of the proposed dosing scheme predicted peak C1INH concentrations above the lower level of the normal range (0.7 U ml−1) for at least 94% of all patients. Conclusions The population PK model for C1INH supports a dosing scheme on a 50 U kg−1 basis up to 84 kg, with a fixed dose of 4200 U above 84 kg. The PK of rhC1INH following repeat administration are consistent with the PK following the first administration. PMID:23594263

  16. Design & construction.

    PubMed

    Souhrada, L

    1991-02-20

    The deepening recession hasn't slowed hospital construction activity--at least not yet. While experts say health care executives should expect fewer large projects within the next two years, as the result of unpredictable sources of capital and increasing censure of hospital capital spending, for the moment hospital projects are helping to shelter some design and construction firms from the recession's fallout.

  17. A bidirectional approach to the synthesis of polypropionates: synthesis of C1-C13 fragment of zincophorin and related isomers.

    PubMed

    Mochirian, Philippe; Godin, François; Katsoulis, Ioannis; Fontaine, Isabelle; Brazeau, Jean-François; Guindon, Yvan

    2011-10-07

    The structure-activity study of a bioactive natural product containing polypropionate subunits requires that its stereoisomers also be evaluated. Therefore, a general approach to synthesize these motifs is necessary. We describe herein the synthesis of the C1-C13 polypropionate subunit of zincophorin and isomers thereof using a two-reaction sequence: an aldol reaction using a mixture of tetrasubstituted enoxysilanes and a hydrogen-transfer reaction, both under Lewis acid control. Selection of the appropriate Lewis acid dictates the stereochemical outcome of these reactions. From a tactical standpoint, this study shows how a polypropionate sequence can be read and constructed in two directions, either the east-west or the west-east approaches. The choice of the optimal route is influenced by the number of complexation sites that can interfere in the aldol step under bidentate Lewis acid control.

  18. Observation of the h(c)(1P) Using e+ e- collisions above the DD threshold.

    PubMed

    Pedlar, T K; Cronin-Hennessy, D; Hietala, J; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Xiao, T; Martin, L; Powell, A; Wilkinson, G; Mendez, H; Ge, J Y; Miller, D H; Shipsey, I P J; Xin, B; Adams, G S; Hu, D; Moziak, B; Napolitano, J; Ecklund, K M; Insler, J; Muramatsu, H; Park, C S; Pearson, L J; Thorndike, E H; Ricciardi, S; Thomas, C; Artuso, M; Blusk, S; Mountain, R; Skwarnicki, T; Stone, S; Zhang, L M; Bonvicini, G; Cinabro, D; Lincoln, A; Smith, M J; Zhou, P; Zhu, J; Naik, P; Rademacker, J; Asner, D M; Edwards, K W; Randrianarivony, K; Tatishvili, G; Briere, R A; Vogel, H; Onyisi, P U E; Rosner, J L; Alexander, J P; Cassel, D G; Das, S; Ehrlich, R; Gibbons, L; Gray, S W; Hartill, D L; Heltsley, B K; Kreinick, D L; Kuznetsov, V E; Patterson, J R; Peterson, D; Riley, D; Ryd, A; Sadoff, A J; Shi, X; Sun, W M; Yelton, J; Rubin, P; Lowrey, N; Mehrabyan, S; Selen, M; Wiss, J; Libby, J; Kornicer, M; Mitchell, R E; Shepherd, M R; Tarbert, C M; Besson, D

    2011-07-22

    Using 586  pb(-1) of e+ e- collision data at E(c.m.) = 4170  MeV, produced at the Cornell Electron Storage Ring collider and collected with the CLEO-c detector, we observe the process e+ e- → π+ π- h(c)(1P). We measure its cross section to be 15.6±2.3±1.9±3.0  pb, where the third error is due to the external uncertainty on the branching fraction of ψ(2S) → π0 h(c)(1P), which we use for normalization. We also find evidence for e+ e- → ηh(c)(1P) at 4170 MeV at the 3σ level and see hints of a rise in the e+ e- → π+ π- h(c)(1P) cross section at 4260 MeV.

  19. Retro-odontoid cystic mass treated by laminectomy and C1-C2 fixation.

    PubMed

    Lin, Dasheng; Ding, Zhenqi; Guo, Yanjie; Lian, Kejian

    2014-11-01

    Retro-odontoid cysts associated with chronic atlantoaxial subluxation are extremely rare. This article describes a case of retro-odontoid cystic mass associated with chronic atlantoaxial subluxation and its management with posterior C1 and partial C2 laminectomy and C1-C2 pedicle screw fixation without resection of the retro-odontoid cyst. A 64-year-old woman experienced a sudden onset of neck pain, hand and foot paresthesia. Atlantoaxial instability associated with a retro-odontoid cystic mass was found in the imaging. The patient underwent posterior C1 and partial C2 laminectomy and C1-C2 pedicle screws fixation without resection of the retro-odontoid cyst. During the 24 months followup period, the cyst disappeared completely and the patient remained symptom free and returned to independent daily living. These findings suggest that posterior laminectomy and fixation without resection of the retro-odontoid cyst is relatively simple and safe and the results are satisfactory.

  20. Development of the Advanced Technology Microwave Sounder (ATMS) for NPOESS C1

    NASA Astrophysics Data System (ADS)

    Brann, C.; Kunkee, D.

    2008-12-01

    The National Polar-orbiting Operational Environmental Satellite System's Advanced Technology Microwave Sounder (ATMS) is planned for flight on the first NPOESS mission (C1) in 2013. The C1 ATMS will be the second instrument of the ATMS series and will provide along with the companion Cross-track Infrared Sounder (CrIS), atmospheric temperature and moisture profiles for NPOESS. The first flight of the ATMS is scheduled in 2010 on the NPOESS Preparatory Project (NPP) satellite, which is an early instrument risk reduction component of the NPOESS mission. This poster will focus on the development of the ATMS for C1 including aspects of the sensor calibration, antenna beam and RF characteristics and scanning. New design aspects of the C1 ATMS, required primarily by parts obsolescence, will also be addressed in this poster.