Solving Discipline and Classroom Management Problems: Methods and Models for Today's Teachers. 6th Edition

ERIC Educational Resources Information Center

Wolfgang, Charles H.

2004-01-01

Offering a wide range of methods and practical advice, this sixth edition equips teachers with tools they need to deal effectively with a range of discipline/management problems in the classroom--from minor misbehavior to serious assaults. The following features are included in this edition: (1) A new chapter discusses how to deal with and support…

24 CFR 3280.304 - Materials.

Code of Federal Regulations, 2013 CFR

2013-04-01

... for Aluminum Structures, Part 1-A, Sixth Edition, October 1994, and Part 1-B, First Edition, October 1994. Steel Specification for Structural Steel Buildings—Allowable Stress Design and Plastic Design..., 2.4, 2.8 through 2.10. Specification for the Design of Cold-Formed Steel Structural Members—AISI...

Teaching Physical Education in Elementary Schools. Sixth Edition.

ERIC Educational Resources Information Center

Vannier, Maryhelen; Gallahue, David L.

This source book of physical education activities for children from nursery school through the sixth grade covers five major areas of concern to the educator. Part one deals with the role of physical education in child development. The second section examines how children of different ages and abilities learn, discussing the preschool child, the…

Assessment in Counseling: Procedures and Practices, Sixth Edition

ERIC Educational Resources Information Center

Hays, Danica G.

2017-01-01

The latest edition of this perennial bestseller instructs and updates students and clinicians on the basic principles of psychological assessment and measurement, recent changes in assessment procedures, and the most widely used tests in counseling practice today. Dr. Danica Hays guides counselors in the appropriate selection, interpretation, and…

Educational Programs That Work. Sixth Edition, Fall 1979.

ERIC Educational Resources Information Center

Far West Lab. for Educational Research and Development, San Francisco, CA.

Intended to stimulate communication among the federal, state, intermediate, local, and postsecondary agencies that share responsibility for the improvement of education, this Department of Education catalog of exemplary educational programs describes all the projects dealt with in previous editions as well as providing information on more than 30…

A Counselor's Guide to Career Assessment Instruments, Sixth Edition

ERIC Educational Resources Information Center

Wood, Chris; Hays, Danica G.

2013-01-01

This book contains exemplary resources for counselors, career development facilitators, school counselors, and other career professionals working in a variety of settings. This edition is an essential guide to career assessment and contains a comprehensive list of career assessment instruments. It has over 70 reviews and includes…

Test Review: Process Assessment of the Learner-Second Edition

ERIC Educational Resources Information Center

Peterson, Lisa S.; Martinez, Andrew; Turner, Terez L.

2010-01-01

This article presents a review of the "Process Assessment of the Learner-Second Edition" (PAL-II), an individual or group-administered instrument designed to assess the cognitive processes involved in academic tasks in kindergarten through sixth grade. The instrument allows the examiner to identify reasons for underachievement and…

Your Reading: A Booklist for Junior High and Middle School Students. Sixth Edition.

ERIC Educational Resources Information Center

Christensen, Jane, Ed.

With many annotations written or edited by students, this booklist contains 3,100 citations of fiction and nonfiction publications for adolescents. Most entries were published within the past few years, although well-written older books are also included. The annotations, which include appropriate age ranges, are categorized as follows:…

VMI-VI and BG-II KOPPITZ-2 for Youth with HFASDs and Typical Youth

ERIC Educational Resources Information Center

McDonald, Christin A.; Volker, Martin A.; Lopata, Christopher; Toomey, Jennifer A.; Thomeer, Marcus L.; Lee, Gloria K.; Lipinski, Alanna M.; Dua, Elissa H.; Schiavo, Audrey M.; Bain, Fabienne; Nelson, Andrew T.

2014-01-01

The visual-motor skills of 90 youth with high-functioning autism spectrum disorders (HFASDs) and 51 typically developing (TD) youth were assessed using the Beery-Buktenica Developmental Test of Visual-Motor Integration, Sixth Edition (VMI-VI) and Koppitz Developmental Scoring System for the Bender-Gestalt Test-Second Edition (KOPPITZ-2).…

Facilities Inventory and Utilization Study, Fall of 1992: For the State of North Carolina. Twenty-Sixth Edition.

ERIC Educational Resources Information Center

North Carolina Univ., Chapel Hill. Commission on Higher Education Facilities.

This publication presents the results of the twenty-sixth annual inventory and utilization study of the status of space in North Carolina institutions of higher education at the end of the drop-add period of the 1992 fall term. The study provides data for 113 institutions, including the public institutions which comprise the University of North…

American College of Physicians Ethics Manual: sixth edition.

PubMed

Snyder, Lois

2012-01-03

Medicine, law, and social values are not static. Reexamining the ethical tenets of medicine and their application in new circumstances is a necessary exercise. The sixth edition of the American College of Physicians (ACP) Ethics Manual covers emerging issues in medical ethics and revisits older ones that are still very pertinent. It reflects on many of the ethical tensions in medicine and attempts to shed light on how existing principles extend to emerging concerns. In addition, by reiterating ethical principles that have provided guidance in resolving past ethical problems, the Manual may help physicians avert future problems. The Manual is not a substitute for the experience and integrity of individual physicians, but it may serve as a reminder of the shared duties of the medical profession.

Book Review: Astronomy: A Self-Teaching Guide, 6th Edition

NASA Astrophysics Data System (ADS)

Marigza, R. N., Jr.

2009-03-01

The sixth edition of Moche's book is up-to-date with the latest in astronomy. It contains accurate astronomical data on stars and constellations. The topics are incorporated with web site addresses for the reader to expand his/her knowledge and see high-resolution images of the celestial targets. This edition incorporates new discoveries and suggestions made prior to the first editions. Among the new developments is the twenty-first-century research into black holes, active galaxies and quasars, searches for life in space, origin and structure of our universe, and the latest in ground and space telescopes.

Introduction to United States Government Information Sources. Sixth Edition. Library and Information Science Text Series.

ERIC Educational Resources Information Center

Morehead, Joe

This book provides an account of the general and specialized sources, in print and non-print formats, that make up the bibliographic and textual structure of federal government information. This edition has been revised to reflect the many changes that have occurred in the production and dissemination of government products within the last five…

22. This is an image from the special edition of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. This is an image from the special edition of the Terre Haute Tribune, Thursday, September 17, 1925. Page size is 14" x 19". This is a reproduction of a pen and ink rendering of the building from the southeast. On microfilm in the Vigo Country Public Library. - John T. Beasley Building, 632 Cherry Street (between Sixth & Seventh Streets), Terre Haute, Vigo County, IN

Secondary School Mathematics Special Edition, Chapter 12. Similarity, Chapter 13. More About Rational Numbers, Chapter 14. Perpendiculars, Student's Text.

ERIC Educational Resources Information Center

DeVenney, William S.; And Others

This text is one of the sequence of textbooks produced for low achievers in the seventh and eighth grades by the School Mathematics Study Group (SMSG). There are eight texts in the sequence, of which this is the sixth. This set of volumes differs from the regular editions of SMSG junior high school texts in that very little reading is required.…

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM TECHNOLOGY PROFILES: SIXTH EDITION

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program evaluates new and promising treatment and monitoring and measurement technologies for cleanup of hazardous waste sites. The program was created to encourage the development and routine use of innovative treatment techn...

Advanced Hepatocellular Carcinoma: Which Staging Systems Best Predict Prognosis?

PubMed Central

Huitzil-Melendez, Fidel-David; Capanu, Marinela; O'Reilly, Eileen M.; Duffy, Austin; Gansukh, Bolorsukh; Saltz, Leonard L.; Abou-Alfa, Ghassan K.

2010-01-01

Purpose The purpose of cancer staging systems is to accurately predict patient prognosis. The outcome of advanced hepatocellular carcinoma (HCC) depends on both the cancer stage and the extent of liver dysfunction. Many staging systems that include both aspects have been developed. It remains unknown, however, which of these systems is optimal for predicting patient survival. Patients and Methods Patients with advanced HCC treated over a 5-year period at Memorial Sloan-Kettering Cancer Center were identified from an electronic medical record database. Patients with sufficient data for utilization in all staging systems were included. TNM sixth edition, Okuda, Barcelona Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), Chinese University Prognostic Index (CUPI), Japan Integrated Staging (JIS), and Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire (GETCH) systems were ranked on the basis of their accuracy at predicting survival by using concordance index (c-index). Other independent prognostic variables were also identified. Results Overall, 187 eligible patients were identified and were staged by using the seven staging systems. CLIP, CUPI, and GETCH were the three top-ranking staging systems. BCLC and TNM sixth edition lacked any meaningful prognostic discrimination. Performance status, AST, abdominal pain, and esophageal varices improved the discriminatory ability of CLIP. Conclusion In our selected patient population, CLIP, CUPI, and GETCH were the most informative staging systems in predicting survival in patients with advanced HCC. Prospective validation is required to determine if they can be accurately used to stratify patients in clinical trials and to direct the appropriate need for systemic therapy versus best supportive care. BCLC and TNM sixth edition were not helpful in predicting survival outcome, and their use is not supported by our data. PMID:20458042

Proceedings of the Sixth General Meeting of the International VLBI Service for Geodesy and Astrometry

NASA Technical Reports Server (NTRS)

Behrend, Dirk (Editor); Baver, Karen D. (Editor)

2010-01-01

This volume is the proceedings of the sixth General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Hobart, Tasmania, Australia, February 7-13, 2010. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2010. The keynote of the sixth GM was the new perspectives of the next generation VLBI system under the theme "VLBI2010: From Vision to Reality". The goal of the meeting was to provide an interesting and informative program for a wide cross-section of IVS members, including station operators, program managers, and analysts. This volume contains 88 papers. All papers were edited by the editors for usage of the English language, form, and minor content-related issues.

A Matrix for Processing Descriptive and Judgmental Data for Use with the Learning Area Sections of the "Evaluative Criteria," Sixth Edition.

ERIC Educational Resources Information Center

Pace, Vernon D.; Buser, Robert L.

1990-01-01

Presents a matrix that can be used by accreditation team members to gather, organize, analyze, and report descriptive and evaluative information about instructional support components, teacher observations/interviews, and curriculum evaluation. (DMM)

[Indian Education Curriculum Guide.] Revised Edition.

ERIC Educational Resources Information Center

McCluskey, Murton L.

This guide contains information and suggestions intended for the teacher planning an Indian unit or American Indian Heritage Day activities. The first five chapters describe American Indian contributions and influences in foods, design, language, government, pharmaceuticals, art, and sports. The sixth chapter contains 24 sources for these…

10 CFR 431.15 - Materials incorporated by reference.

Code of Federal Regulations, 2013 CFR

2013-01-01

... INDUSTRIAL EQUIPMENT Electric Motors Test Procedures, Materials Incorporated and Methods of Determining... of Energy, Office of Energy Efficiency and Renewable Energy, Building Technologies Program, Sixth.... (1) IEC 60034-1 Edition 12.0 2010-02, (“IEC 60034-1”), Rotating Electrical Machines, Part 1: Rating...

The School and Community Relations. Sixth Edition.

ERIC Educational Resources Information Center

Gallagher, Donald R.; Bagin, Don; Kindred, Leslie W.

Ways in which educators can communicate well, and subsequently gain support for programs, curriculum, and discipline, are presented. The book is divided into four parts: "Essential Considerations,""Relations with Special Publics,""Communication Tools," and "Evaluation." In part 1, some of the topics discussed include the importance of public…

Hamilton and Hardy for the 21st Century

PubMed Central

Ogden, Trevor

2016-01-01

Hamilton and Hardy’s Industrial Toxicology is now 80 years old, and the new sixth edition links us with a pioneer era. This is an impressive book, but the usefulness of the hardback version as a reference book is unfortunately limited by its poor index. There is now an ebook version, and for the practitioner on the move this has the great advantages of searchability and portability. However, Wiley ebooks can apparently only be downloaded when first purchased, so their lifetime is limited to that of the device. The Kindle edition should avoid this shortcoming.

Administration of High School Athletics. Sixth Edition.

ERIC Educational Resources Information Center

Forsythe, Charles A.; Keller, Irvin A.

This text was prepared to aid three groups of people: those who expect to become teachers, supervisors, or directors of physical education and athletics; those already in the field administering high school physical education programs; and those whose primary interest is coaching but who need suggestions and guidance in handling attendant…

Communication. Listen, Speak, Write, Use.

ERIC Educational Resources Information Center

University of Northern Iowa, Cedar Falls. School of Business.

This instructional unit is intended for use in helping secondary and postsecondary business students develop their communications skills. The course is designed to be taught in six weeks in conjunction with the sixth edition of "Business English and Communication," a textbook published by McGraw-Hill. Chapters addressing listening, speaking,…

Facts & Figures, 1999: A Compendium of Statistics on Ontario Universities.

ERIC Educational Resources Information Center

Council of Ontario Universities, Toronto.

This is the sixth edition of statistical and graphical information on the Ontario (Canada) university system. The report contains six sections: (1) Ontario population data, which includes population projections to 2021, income and employment rates by educational attainment, and university participation rates; (2) applicant/registrant data, which…

Technician Education Yearbook 1973-1974.

ERIC Educational Resources Information Center

Prakken, Lawrence D., Ed.

In this sixth (1973-74) edition of the Technician Education Yearbook, the current status in the development of community/junior colleges and technical institutes is presented on the basis of information gathered from replies to more than 3,000 questionnaires. Nine articles relating to new issues, problems, and proposals are compiled in the first…

WITHDRAWN: Kee, J, Hayes E. and McCuistion L (2009) Pharmacology: A Nursing Process Approach, Sixth Edition (and accompanying study guide), Saunders Elsevier, St. Louis.

PubMed

Keogh, Brian

2009-08-22

The Publisher regrets that this article is an accidental duplication of a Book Review that has already been published, doi: 10.1016/j.nepr.2009.07.002. The duplicate article has therefore been withdrawn.

Manual for Librarians in Small Hospitals. Sixth Edition.

ERIC Educational Resources Information Center

Graham, Elaine, Ed.; Kesti, Julie, Ed.

This manual is designed to aid the inexperienced person assigned to a hospital library and given the responsibility of ordering library materials, organizing the collection, borrowing from other libraries, and seeking information. Following a brief introduction, the manual is divided into 10 chapters: (1) Organization and Administration of the…

Student Preparation Workbook for the Multnomah Outdoor School. Teacher Edition. Revised.

ERIC Educational Resources Information Center

Bohm, Rudy; Cole, Wally

Designed for use by sixth grade teachers in preparing their classes for the Multnomah County (Oregon) Outdoor School experience, the guide to the Student Preparation Workbook provides general information, descriptions, game materials, and answers to the exercises and puzzles. Beginning with an introduction to environmental manners (rules for…

Counseling and Psychotherapy: Theories and Interventions, Sixth Edition

ERIC Educational Resources Information Center

Capuzzi, David, Ed.; Stauffer, Mark D., Ed.

2016-01-01

Featuring important theories and trends not covered in other foundational texts, this book is designed to equip the next generation of counselors with the tools they need for understanding the core dimensions of the helping relationship. Topical experts provide contemporary information and insight on the following theories: psychoanalytic,…

Oregon School Bond Manual. Sixth Edition.

ERIC Educational Resources Information Center

Oregon State Dept. of Education, Salem. Office of School District Services.

Given that purchasers of Oregon school bonds rely on recommendations of accredited bond attorneys, this document is designed to assist school districts in complying with state statutes regulating the issuance of school bond issues in order that attorney opinions may be favorable. Six initial steps toward a bond sale and Oregon laws regarding bonds…

Californians & Education. PPIC Statewide Survey

ERIC Educational Resources Information Center

Baldassare, Mark; Bonner, Dean; Petek, Sonja; Willcoxon, Nicole

2010-01-01

This edition of the PPIC (Public Policy Institute of California) Statewide Survey is the sixth in a series of surveys funded by The William and Flora Hewlett Foundation focusing on K-12 education issues. Its goal is to inform state policymakers, encourage discussion, and raise public awareness about a variety of K-12, higher education,…

School Health Practice. Sixth Edition.

ERIC Educational Resources Information Center

Anderson, C. L.; Creswell, William H.

This text provides core subject matter relating to health services, health education, and healthful living for teachers, health educators, school nurses, administrators, and any others who have a role in the school health program. Its six parts focus on the what, how, and why of a functional school health program today. To start, the history of…

Who's Involved with Hunger: An Organization Guide for Education and Advocacy. Sixth Edition.

ERIC Educational Resources Information Center

Kutzner, Patricia L.; And Others

This directory provides key information on agencies and organizations instrumental in the fight against hunger. The guide is divided into three parts. Part 1, "Governmental Organizations and Agencies," lists: (1) "U.S. Congress"; (2) "U.S. Federal Government Agencies"; and (3) "United Nations Intergovernmental Organizations." Part 2, "World…

Leadership: Theory and Practice. Sixth Edition

ERIC Educational Resources Information Center

Northouse, Peter G.

2012-01-01

Adopted at more than 1,000 colleges and universities worldwide, the market-leading text owes its success to the unique way in which it combines an academically robust account of the major theories and models of leadership with an accessible style and practical exercises that help students apply what they learn. Each chapter of Peter…

Science for Society: A Bibliography, Sixth Edition.

ERIC Educational Resources Information Center

Dasbach, Joseph M.

Presented is an annotated bibliography of selected books published from 1972-75 and articles appearing from July 1974 to July 1975 with topics focusing on the interrelationship of humankind, the environment, science, and technology. For students and teachers in the natural and social sciences at both secondary and college levels, the listings are…

From Teacher to Writer: How Does It Happen?

ERIC Educational Resources Information Center

Lewis, Barbara A.

1992-01-01

Discusses a sixth grade teacher's experience in turning a classroom project into a book. Offers advice for teachers on becoming writers. Explores obstacles, benefits, and suggestions on writing, editing, and publishing work. Describes a class project that resulted in the cleanup of a toxic waste site and the publication of "The Kid's Guide to…

Student Preparation Workbook for the Multnomah Outdoor School. Revised Edition.

ERIC Educational Resources Information Center

Bohm, Rudy; Cole, Wally

Designed for sixth grade students to help them prepare for the Multnomah County (Oregon) Outdoor School experience, the workbook provides fundamental information about soil, water, plant, and animal resources. The workbook begins with an introduction to environmental manners (rules for working in the woods). A section devoted to each resource area…

Human Resources Administration in Education: A Management Approach. Sixth Edition.

ERIC Educational Resources Information Center

Rebore, Ronald W.

This book reflects the changing aspects of school human-resources management. Current concerns include the impact of new laws related to disabilities, civil rights, family and medical leave, and the testing of school bus drivers for alcohol and controlled substances. Also examined are human resources' responsibilities to military reservists and…

Fire and the Design of Educational Buildings. Building Bulletin 7. Sixth Edition.

ERIC Educational Resources Information Center

Department of Education and Science, London (England).

This bulletin offers guidance on English school premises regulations applying to safety protection against fires in the following general areas: means of escape in case of fire; precautionary measures to prevent fire; fire warning systems and fire fighting; fire spreading speed; structures and materials resistant to fires; and damage control. It…

Financing Education in a Climate of Change. Sixth Edition.

ERIC Educational Resources Information Center

Burrup, Percy E.; Brimley, Vern, Jr.; Garfield, Rulon R.

As the United States prepares for the 21st century, questions regarding the high cost of education have increased in volume. Many of these questions and issues are addressed in this textbook. The text is intended for a beginning course in school finance, but school administrators, teachers, school board members, legislators, and others interested…

Testing Confounds to a Developmental Theory of Children's Learning from Television.

ERIC Educational Resources Information Center

Lometti, Guy E.

Children's learning from television was studied in 343 fourth, sixth, seventh, and eighth grade students who viewed an edited version of a television program and took a posttest. It was hypothesized that children would learn more plot-relevant information (central learning material) as they moved from concrete operational to formal operational…

Advancing Integrated STEM Learning through Engineering Design: Sixth-Grade Students' Design and Construction of Earthquake Resistant Buildings

ERIC Educational Resources Information Center

English, Lyn D.; King, Donna; Smeed, Joanna

2017-01-01

As part of a 3-year longitudinal study, 136 sixth-grade students completed an engineering-based problem on earthquakes involving integrated STEM learning. Students employed engineering design processes and STEM disciplinary knowledge to plan, sketch, then construct a building designed to withstand earthquake damage, taking into account a number of…

Assessment of CPA Candidates' Education: Part Two

ERIC Educational Resources Information Center

Giffin, Richard B.; Geddie, Mary; Moser, Ernest; Griffin, B. Wynne

2012-01-01

This paper is the second of a two part study comparing The Sixth Edition of the Uniform Accountancy Act as prepared and adopted by the National Association of State Boards of Accountancy (NASBA)with the actual regulatory practice of the various jurisdictional boards of accountancy in place just prior to the release of the most recent NASBA…

Reflections on Classroom Thinking Strategies: Practical Strategies to Encourage Thinking in Your Classroom. Sixth Edition

ERIC Educational Resources Information Center

Frangenheim, Eric

2005-01-01

The major purpose of this book is to introduce teachers (and by that the author means all types of teachers-classroom teachers, administrators, teacher aids, parents and coaches) to various individual and group thinking strategies related to specific questions and activities. This guide is a personal interpretation and critique of those strategies…

Characteristics of Emotional and Behavioral Disorders of Children and Youth. Sixth Edition.

ERIC Educational Resources Information Center

Kauffman, James M.

This book is designed as an introductory text on special education for children and youth with emotional and behavioral disorders. Part 1 addresses the problems in the definition of emotional and behavioral disorders, the prevalence of the disorders, the growth of the field of emotional and behavior disorders, and major current trends. Part 2…

Suggestions for Teaching Mathematics Using Laboratory Approaches. 6. Probability. Experimental Edition.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Bureau of Elementary Curriculum Development.

This guide is the sixth in a series of publications to assist teachers in using a laboratory approach to mathematics. Twenty activities on probability and statistics for the elementary grades are described in terms of purpose, materials needed, and procedures to be used. Objectives of these activities include basic probability concepts; gathering,…

Biological Science: An Ecological Approach. BSCS Green Version. Teacher's Resource Book and Test Item Bank. Sixth Edition.

ERIC Educational Resources Information Center

Biological Sciences Curriculum Study, Colorado Springs.

This book consists of four sections: (1) "Supplemental Materials"; (2) "Supplemental Investigations"; (3) "Test Item Bank"; and (4) "Blackline Masters." The first section provides additional background material related to selected chapters and investigations in the student book. Included are a periodic table of the elements, genetics problems and…

Requirements for Certification For Elementary Schools, Secondary Schools, and Junior Colleges. Teachers, Counselors, Librarians, Administrators. Forty-Sixth Edition.

ERIC Educational Resources Information Center

Woellner, Elizabeth H.

This book lists certification standards for teachers, school librarians, school counselors, and administrators in each of the fifty states and the District of Columbia. Types of degrees and specializations required, duration of the certification, and application procedures are outlined. The certification recommendations of the Middle States…

Requirements for Certification of Teachers, Counselors, Librarians, Administrators for Elementary and Secondary Schools. Seventy-Sixth Edition, 2011-2012

ERIC Educational Resources Information Center

Kaye, Elizabeth A., Ed.

2011-01-01

This annual volume offers the most complete and current listings of the requirements for certification of a wide range of educational professionals at the elementary and secondary levels. "Requirements for Certification" is a valuable resource, making much-needed knowledge available in one straightforward volume. [For "Requirements…

Alternatives to the Peace Corps: A Directory of Third World & U.S. Volunteer Opportunities. Sixth Edition.

ERIC Educational Resources Information Center

Olson, Annette, Ed.

Some returned Peace Corps volunteers believe that U.S. foreign policy has been more damaging than helpful in the Third World. They question the links between U.S. foreign and military policy and the Peace Corps. This book addresses such questions and brings together resources and information that will help the prospective volunteer find an…

Kids Count Data Book. State Profiles of Child Well-Being. 1995.

ERIC Educational Resources Information Center

Annie E. Casey Foundation, Baltimore, MD.

Kids Count is a national and state-by-state effort to track the status of children in the United States. By providing policy-makers and citizens with benchmarks of child well-being, the project attempts to enrich discussions about ways to secure better futures for all children. This year's data book, the sixth annual edition, places a special…

The Playing Field. A Curriculum Guide to Pesticide Education for Fourth, Fifth, and Sixth Grades. First Edition.

ERIC Educational Resources Information Center

Bellissemo, Diane; Garcia, Deliana

A pesticide safety video for children 9-12 years old, "The Playing Field," draws children into the lives of a migrant farmworker family while teaching them about the dangers of pesticides. The video and the lessons are not limited to migrant education, but open a multicultural window for all children, migrant or nonmigrant. Teaching elements for…

Bibliography: NIE Publications. More Than 100 Teacher Guides and Curriculum Materials To Aid the Classroom Use of Newspapers. Sixth Edition.

ERIC Educational Resources Information Center

American Newspaper Publishers Association Foundation, Washington, DC.

This bibliography lists 124 publications designed to answer the question of how to use the newspaper in the school curriculum. The bibliography is one facet of a continuing effort to assist hundreds of newspapers and school systems sponsoring Newspaper in Education programs. Most of the materials in the bibliography are published by newspapers, in…

Trash Treasures. Operation Waste Watch: The New Three Rs for Elementary School. Grade 5. [Second Edition.

ERIC Educational Resources Information Center

Virginia State Dept. of Waste Management, Richmond. Div. of Litter & Recycling.

This publication, the sixth in a series of seven for elementary schools, is an environmental education curriculum guide with a focus on waste management issues. While children may be unable to resolve other environmental problems litter is cited as one pollutant that they can comprehend and solve. They can learn to dispose of waste properly, help…

Community Solutions to Solid Waste Pollution. Operation Waste Watch: The New Three Rs for Elementary School. Grade 6. [Second Edition.

ERIC Educational Resources Information Center

Virginia State Dept. of Waste Management, Richmond. Div. of Litter & Recycling.

This publication, the last in a series of seven for elementary schools, is an environmental education curriculum guide with a focus on waste management issues. It contains a unit of exercises selected for sixth grade students focusing on community solutions to solid waste pollution. Waste management activities included in this unit seek to…

Fundamentals of Physics, 6th Edition Enhanced Problems Version

NASA Astrophysics Data System (ADS)

Halliday, David; Resnick, Robert; Walker, Jearl

2002-04-01

No other text on the market today can match the success of Halliday, Resnick and Walker's Fundamentals of Physics. This text continues to outperform the competition year after year, and the new edition will be no exception. Intended for Calculus-based Physics courses, the 6th edition of this extraordinary text is a major redesign of the best-selling 5th edition, which still maintains many of the elements that led to its enormous success. Jearl Walker adds his unique style to this edition with the addition of new problems designed to capture, and keep, students' attention. Nearly all changes are based on suggestions from instructors and students using the 5th edition, from reviewer comments, and from research done on the process of learning. The primary goal of this text is to provide students with a solid understanding of fundamental physics concepts, and to help them apply this conceptual understanding to quantitative problem solving. The principal goal of Halliday-Resnick-Walker is to provide instructors with a tool by which they can teach students how to effectively read scientific material and successfully reason through scientific questions. To sharpen this tool, the Enhanced Problems Version of the sixth edition of Fundamentals of Physics contains over 1000 new, high-quality problems that require thought and reasoning rather than simplistic plugging of data into formulas.

Lymph node density vs. the American Joint Committee on Cancer TNM nodal staging system in node-positive bladder cancer in patients undergoing extended or super-extended pelvic lymphadenectomy.

PubMed

Lee, Donghyun; Yoo, Sangjun; You, Dalsan; Hong, Bumsik; Cho, Yong Mee; Hong, Jun Hyuk; Kim, Choung-Soo; Ahn, Hanjonh; Ro, Jae Y; Jeong, In Gab

2017-04-01

We compared the prognostic value of the American Joint Committee on Cancer (AJCC) TNM nodal staging system with that of lymph node (LN) density in patients with LN-positive bladder cancer who received extended or super-extended pelvic lymphadenectomy. Of the 1,018 patients, who underwent radical cystectomy and pelvic lymphadenectomy between February 2005 and August 2014, 110 patients with LN metastases with extended (n = 68) or super-extended (n = 42) pelvic lymphadenectomy were included. All patients were staged using the 2002 (sixth edition) and 2010 (seventh edition) AJCC TNM staging systems. The association of several variables with recurrence-free survival (RFS) and overall survival (OS) was evaluated. The median number of total LNs removed was 29 (6-118) and the median LN density was 12.5% (1.6%-100%). RFS and OS were not significantly different between the 2002 (pN1-pM1) and 2010 (pN1-N3) AJCC TNM nodal staging systems (sixth edition: P = 0.512 and P = 0.519; seventh edition: P = 0.676 and P = 0.671, respectively). The 2-year RFS and OS rates according to the LN density quartiles were 58.5% and 76.9% in Q1, 39.1% and 70.8% in Q2, 28.8% and 50.1% in Q3, and 12.7% and 20.8% in Q4 (P = 0.001 and P = 0.001, respectively). Multivariate analysis adjusted for the 2010 AJCC TNM staging system showed that LN density was associated with a decreased OS (HR = 1.024; 95% CI: 1.010-1.039; P = 0.001). The nodal staging system (2002 or 2010) was not associated with the RFS and OS. LN density shows a better prognostic value than the AJCC TNM nodal staging system in patients with LN-positive bladder cancer receiving extended or super-extended pelvic lymphadenectomy. Copyright © 2017 Elsevier Inc. All rights reserved.

The Monthly Sky Guide: Sixth Edition

NASA Astrophysics Data System (ADS)

Ridpath, Ian; Tirion, Wil

2003-06-01

The latest edition of Ian Ridpath and Wil Tirion's popular guide to the night sky is updated for planet positions and forthcoming eclipses up to the end of the year 2007. With one chapter for each month of the year, this is an easy-to-use handbook for anyone wanting to identify constellations, star clusters, nebulae, to plot the movement of planets, or witness solar and lunar eclipses. Most of the features discussed are visible to the naked eye and all can be seen with a small telescope or binoculars. Ian Ridpath has been a full-time writer, broadcaster and lecturer on astronomy and space for more than twenty-five years. He has written and edited more than 40 books, including A Comet Called Haley (Cambridge, 1985). Wil Tirion made his first star map in 1977. It showed stars to the magnitude of 6.5 and was issued as a set of maps by the British Astronomical Association in 1981. He has illustrated numerous books and magazines, including The Cambridge Star Atlas (Cambridge, 2001). Previous Edition Pb (1999): 0-521-66771-2

Life-Cycle Costs of Alternative ICBM Second Stage Designs

DTIC Science & Technology

1992-09-01

of Logistics, Air Force Institute of Technology (AU), Wright-Patterson AFB OH, 1992. 34. Horngren , Charles T. and George Foster. Cost Accounting ; A...Managerial Emphasis (Sixth Edition). Englewood Cliffs NJ: Prentice-Hall, Inc., 1987. 35. Horngren , Charles T. and George Foster. Cost Accounting ; A...our research. We would also like to thank those involved with the 1991 Small ICBM Operations and Support cost estimate. Your assistance with the O& S

Peterson's College Money Handbook 1989. The Only Complete Guide to Scholarships, Costs, and Financial Aid at U.S. Colleges. Sixth Edition.

ERIC Educational Resources Information Center

Lehman, Andrea E., Ed.; Suber, Eric A., Ed.

A comprehensive guide to the cost of a college education today and the ways colleges and other sources can help people meet that cost is presented. All accredited institutions in the United States and U.S. territories offering full 4- or 5-year baccalaureate degree programs are included except institutions with primarily part-time, correspondence,…

Shipboard Tests of Halon 1301 Test Gas Simulants

DTIC Science & Technology

1990-08-22

Halon 1301 Test Gas Simulants," Memo Report, Naval Research Laboratory, Washington, DC, 1989. 8. Air Products and Chemicals , Inc ., "SF6 , An... Products and Chemicals , Inc ., "Specialty Gas Material Safety Data Sheet, Sulfur Hexafluoride " Air Products and Chemicals, Specialty Gas Department...34 Washington, DC, 1978. 11. N.I. Sax, Dangerous Properties of Industrial Materials, Sixth Edition, Van Nostrand Reinhold Company, New York, NY, 1984. 12. Air

Servant Leadership in English Sixth Form Colleges: What Do Teachers Tell Us?

ERIC Educational Resources Information Center

Stoten, David William

2013-01-01

Purpose: The purpose of this paper is to investigate whether servant leadership can be applied to college management. The research methodology involved questionnaire and co-constructed discussion eliciting the views of teachers on how they interpret leadership in a sixth form college. Three other models of leadership were discussed along with…

The Responses of Economically Advantaged and Economically Disadvantaged Sixth Grade Pupils to Science Demonstrations.

ERIC Educational Resources Information Center

Wagner, Bartlett Adam

Compared were written, oral, and construction responses to science demonstrations of economically advantaged and disadvantaged sixth grade students. The study was designed to gain a greater understanding of academic performance of disadvantaged pupils in elementary school science. Five demonstrations were presented to each pupil, who then wrote…

Design and Implementation of a Three-Tiered Web-Based Inventory Ordering and Tracking System Prototype Using CORBA and Java

DTIC Science & Technology

2000-03-01

languages yet still be able to access the legacy relational databases that businesses have huge investments in. JDBC is a low-level API designed for...consider the return of investment . The system requirements, discussed in Chapter II, are the main source of input to developing the relational...1996. Inprise, Gatekeeper Guide, Inprise Corporation, 1999. Kroenke, D., Database Processing Fundementals , Design, and Implementation, Sixth Edition

United States Air Force Summary, Sixth Edition

DTIC Science & Technology

1980-04-01

Schweiker, Richard S. (PA) Republicans Chiles, Lawton (FL) Johnston, J. Bennett, Jr. (IA) Huddleston, Walter D. (D") Burdick, Quentin N. (ND) Leahy...Stevens, Ted (AR) Schweiker, Richard s. (PA) Bellrron, Henry (OK) Republicans Chiles, Lawton (FL) Johnston, J. Bennett, Jr. (IA) Huddleston, ~7alter D...Janes R. (TN) Iaxalt, Paul (NV) • AF/ACBME/48no HOUSE APPROPRIATIONS COMMITTEE Darocrats REF 3 Whitten, Jamie L. (MS) Chai.rm3n Boland, Edward P. (MA

Std 598, valve inspection and testing, sixth edition, September 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-01-01

This book covers inspection, supplementary examination, and pressure test requirements for both resilient-seated and metal-to-metal-seated gate, globe, plug, ball, check, and butterfly valves for the petroleum refinery service. The inspection requirements pertain to inspection by the purchaser and to any supplementary examinations the purchaser may require at the valve manufacturer's plant. The testing requirements cover both required and optional pressure tests by the valve manufacturer at his plant.

Brain Development and the Education of Children from Birth to Age Three. West Virginia KIDS COUNT Data Book: 1997 County Profiles of Child Well-Being.

ERIC Educational Resources Information Center

West Virginia Kids Count Fund, Charleston.

This sixth annual edition of the West Virginia Kids Count data book examines county and statewide trends in the well-being of West Virginia's children, focusing on brain development and educational initiatives for children from birth to 3 years of age. The statistical portrait is based on 11 well-being indicators: (1) percent low birthweight…

Fifty-sixth supplement to the American Ornithologists' Union: Check-list of North American Birds

USGS Publications Warehouse

Chesser, R. Terry; Banks, Richard C.; Burns, Kevin J; Cicero, Carla; Dunn, Jon L.; Kratter, Andrew W.; Lovette, Irby J.; Navarro-Siguenza, Adolfo G.; Rasmussen, Pamela C.; Remsen, J V; Rising, James D.; Stotz, Douglas F.; Winker, Kevin

2015-01-01

This is the 15th supplement since publication of the 7th edition of the Check-list of North American Birds (American Ornithologists' Union [AOU] 1998). It summarizes decisions made between May 15, 2014, and April 15, 2015, by the AOU's Committee on Classification and Nomenclature - North and Middle America. The Committee has continued to operate in the manner outlined in the 42nd Supplement (AOU 2000).

Recruiting Trends 1996-97. A National Study of Job Market Trends for New College Graduates among 508 Businesses, Industries, and Governmental Agencies. Twenty-Sixth Edition.

ERIC Educational Resources Information Center

Scheetz, L. Patrick

This study examined recruiting trends of business, industry, and government among new college graduates. Questionnaires were mailed to 4,890 employers, of which 489 returned complete responses. The survey found that new college graduates of 1996-97 can expect growth in job opportunities. An increase of 6.2 percent in job prospects and an increase…

A Study on Sixth Grade Students' Misconceptions and Errors in Spatial Measurement: Length, Area, and Volume

ERIC Educational Resources Information Center

Tan Sisman, Gulcin; Aksu, Meral

2016-01-01

The purpose of the present study was to portray students' misconceptions and errors while solving conceptually and procedurally oriented tasks involving length, area, and volume measurement. The data were collected from 445 sixth grade students attending public primary schools in Ankara, Türkiye via a test composed of 16 constructed-response…

Oliver Bloodstein: reflections on a career. Interview by Mark Onslow.

PubMed

Onslow, Mark

2007-01-01

Oliver Bloodstein arrived at the University of Iowa in 1941 to study under Wendell Johnson. There he began an influential career that included a seminal documentation of the development of stuttering, the development of the continuity hypothesis and the anticipatory struggle hypothesis, and the writing of five editions of the influential text "A Handbook on Stuttering." In this interview Dr. Bloodstein reflects on his remarkable and inspiring career, which continues today with his involvement in the preparation of a sixth edition of this text. The reader will: (1) describe the contribution to the field of stuttering made by Dr. Bloodstein; (2) discuss the career influences that led to his achievements; (3) know Dr. Bloodstein's current views on the cause of stuttering; and (4) identify the locations at which he worked during his career.

2. TYPICAL OVERHEAD WIRE CONSTRUCTION CURVE GUY WIRE ARRANGEMENT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. TYPICAL OVERHEAD WIRE CONSTRUCTION - CURVE GUY WIRE ARRANGEMENT (ABANDONED WEST LEG OF WYE AT SIXTH AVENUE AND PINE STREET) - Yakima Valley Transportation Company Interurban Railroad, Trackage, Yakima, Yakima County, WA

The relation between children’s constructive play activities, spatial ability, and mathematical word problem-solving performance: a mediation analysis in sixth-grade students

PubMed Central

Oostermeijer, Meike; Boonen, Anton J. H.; Jolles, Jelle

2014-01-01

The scientific literature shows that constructive play activities are positively related to children’s spatial ability. Likewise, a close positive relation is found between spatial ability and mathematical word problem-solving performances. The relation between children’s constructive play and their performance on mathematical word problems is, however, not reported yet. The aim of the present study was to investigate whether spatial ability acted as a mediator in the relation between constructive play and mathematical word problem-solving performance in 128 sixth-grade elementary school children. This mediating role of spatial ability was tested by utilizing the current mediation approaches suggested by Preacher and Hayes (2008). Results showed that 38.16% of the variance in mathematical word problem-solving performance is explained by children’s constructive play activities and spatial ability. More specifically, spatial ability acted as a partial mediator, explaining 31.58% of the relation between constructive play and mathematical word problem-solving performance. PMID:25101038

Polyhedron Models for the Classroom. Second Edition.

ERIC Educational Resources Information Center

Wenninger, Magnus J.

This second edition explains the historical background and techniques for constructing various types of polyhedra. Seven center-fold sheets are included, containing full-scale drawings from which nets or templates may be made to construct the models shown and described in the text. Details are provided for construction of the five Platonic solids,…

Comparing Science Achievement Constructs: Targeted and Achieved

ERIC Educational Resources Information Center

Ferrara, Steve; Duncan, Teresa

2011-01-01

This article illustrates how test specifications based solely on academic content standards, without attention to other cognitive skills and item response demands, can fall short of their targeted constructs. First, the authors inductively describe the science achievement construct represented by a statewide sixth-grade science proficiency test.…

Constructs and methods for genome editing and genetic engineering of fungi and protists

DOEpatents

Hittinger, Christopher Todd; Alexander, William Gerald

2018-01-30

Provided herein are constructs for genome editing or genetic engineering in fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. The constructs may also include selectable markers for use in selecting recombinations.

Modelling in Primary School: Constructing Conceptual Models and Making Sense of Fractions

ERIC Educational Resources Information Center

Shahbari, Juhaina Awawdeh; Peled, Irit

2017-01-01

This article describes sixth-grade students' engagement in two model-eliciting activities offering students the opportunity to construct mathematical models. The findings show that students utilized their knowledge of fractions including conceptual and procedural knowledge in constructing mathematical models for the given situations. Some students…

12th Annual School Construction Report, 2007

ERIC Educational Resources Information Center

Abramson, Paul

2007-01-01

School construction completed in 2006 totaled just more than $20 billion, a drop of seven percent from the record $21.6 billion put in place in 2005. Even so, it was the sixth year in the last seven that annual construction exceeded $20 billion. During the seven years of the present century, school districts have completed construction projects…

Research notes : exploratory study of hot-in-place recycling of asphalt pavements.

DOT National Transportation Integrated Search

1995-06-01

In 1992, the Oregon Department of Transportation (ODOT) contracted for six hot in-place recycling (HIR) projects for rehabilitation of asphalt concrete pavements. Five projects were constructed in 1992; the sixth was constructed in 1993.

Orthogonal-blendshape-based editing system for facial motion capture data.

PubMed

Li, Qing; Deng, Zhigang

2008-01-01

The authors present a novel data-driven 3D facial motion capture data editing system using automated construction of an orthogonal blendshape face model and constrained weight propagation, aiming to bridge the popular facial motion capture technique and blendshape approach. In this work, a 3D facial-motion-capture-editing problem is transformed to a blendshape-animation-editing problem. Given a collected facial motion capture data set, we construct a truncated PCA space spanned by the greatest retained eigenvectors and a corresponding blendshape face model for each anatomical region of the human face. As such, modifying blendshape weights (PCA coefficients) is equivalent to editing their corresponding motion capture sequence. In addition, a constrained weight propagation technique allows animators to balance automation and flexible controls.

Effect of Electronic Editing on Error Rate of Newspaper.

ERIC Educational Resources Information Center

Randall, Starr D.

1979-01-01

A study of a North Carolina newspaper indicates that newspapers using fully integrated electronic editing systems have fewer errors in spelling, punctuation, sentence construction, hyphenation, and typography than newspapers not using electronic editing. (GT)

"...If We Were Cavemen We'd Be Fine": Facebook as a Catalyst for Critical Literacy Learning by Dyslexic Sixth-Form Students

ERIC Educational Resources Information Center

Barden, Owen

2012-01-01

This article is derived from a study of the use of Facebook as an educational resource by five dyslexic students at a sixth form college in north-west England. Through a project in which teacher-researcher and student-participants co-constructed a group Facebook page about the students' scaffolded research into dyslexia, the study examined the…

Integers as Transformations.

ERIC Educational Resources Information Center

Thompson, Patrick W.; Dreyfus, Tommy

1988-01-01

Investigates whether elementary school students can construct operations of thought for integers and integer addition crucial for understanding elementary algebra. Two sixth graders were taught using a computer. Results included both students being able to construct mental operations for negating arbitrary integers and determining sign and…

Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan

ERIC Educational Resources Information Center

Des Jardin, Molly Catherine

2012-01-01

"Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan" problematizes widespread acceptance of anthologies of authors' "complete works" as both transparent and authoritative compendia of Japanese literature. In the Meiji period (1868-1912), they enjoyed a sudden boom in popularity and have…

Power Product Equipment Technician: Construction Equipment. Teacher Edition. Student Edition.

ERIC Educational Resources Information Center

Hilley, Robert

The instructor's guide in this package, which is one in a series of new publications developed to replace the Multistate Academic and Vocational Curriculum Consortium's previous small-engine curricula, contains the materials required to teach a competency-based course in repairing construction equipment. The guide begins with an introduction…

Update on fly ash technology relating to highway construction : January 1983.

DOT National Transportation Integrated Search

1983-01-01

This report abstracts the information concerning the use of fly ash in highway construction contained in the Proceedings of the Sixth International Ash Utilization Symposium held March 7-10, 1982, at Reno, Nevada. The Proceedings include 54 papers, o...

[Wikipedia and wikinutrition: key tools for the global promotion of nutrition].

PubMed

Sanz-Valero, J; Wanden-Berghe, C; Culebras-Fernández, J M; Gil, A; Ruiz, M D; Luengo, L M; Veiga, J

2012-01-01

Wikipedia is an encyclopedia collaboratively edited by volunteers from around the world built on the Web since 2003. Today is the sixth most visited site on the Internet, making it the biggest hit of participatory democracy in the field of information dissemination. The English edition, with more than 3 million items, has become an indispensable part of the Internet and the largest and most popular reference work. In this context, it could be argued that Wikipedia is a valuable tool for the general knowledge of the nutritional sciences terminology. At the same time, it does not only facilitate access to knowledge but also can generate it. It also permits to socialize these spaces for collaboration and development, contributing therefore to disclose science to the society. Consequently, in this article we present and discuss the main features of Wikipedia, emphasizing above all its role in food science and nutrition.

Sexism in Two Editions of a Primary Reading Series.

ERIC Educational Resources Information Center

Garrity, Kathleen

A study compared the 1975 and 1983 editions of the "Macmillan Reading Program Series" primary readers in order to examine sex role portrayals. It was hypothesized that the 1983 edition would show an increase in portrayals of non-sexist roles when compared with the 1975 edition. A checklist was constructed to record instances of sexism…

United States Air Force Statistical Digest, Fiscal Year 1951. Sixth Edition

DTIC Science & Technology

1952-11-18

2 2 2 Mili tary Air Transport Service Squadron - Total 2 2 g 2 g g 2 s 1 ! 1 ! , curce a Qrganhat10n geccr- de (AFASC-6F)j oenerea orden from Major...STATISTICAL SERVICES DeS COMPTROLLER", USAF WASHINGTON, DC .J DEPARTMENT OF THE AIR FORCE WASHINGTON, 20 SEPTEMBER 1948 Am FORCE REGULATION) NO. 5-24...AND LUBES. 223 PART V III STOCKPILING •. 235 PART IX INDUSTRIAL RESERVE’ 241 PART X TRANSPORTATION ..• Z8S PART X I RESEARCH AND DEVELOPMENT 2𔄁 t

A Study of the Effect of Hydrocarbon Structure on the Induction of Male Rat Nephropathy and Metabolic Structure

DTIC Science & Technology

1993-08-31

rats yield the molecules 1 - indanol and 1 -indanone from the kidney homogenate extracts [421. Tetralin, which produced more renal damage than indan, did...G.B.. 1955. The oxidation of ketones to esters. I. Am. Chem. Soc. 77, 2287-2290.I 14. Finar, I.L. 1986. In Organic Chemistry Vol 1 , sixth edition...substituted at carbon-3. The only metabolic products which show no oxidation at3 carbon-2, carbon-3 or carbon-6 of 3-MH were 1 , 2, 8, 12 and 16. However

Children's Social Constructions of Popularity.

ERIC Educational Resources Information Center

Lease, A. Michele; Kennedy, Charlotte A.; Axelrod, Jennifer L.

2002-01-01

Assessed fourth, fifth- and sixth-graders' social constructions of popularity using perceived popularity nominations and sociometric measures. Found that perceived popularity is related to sociometric popularity and social dominance. Examined correlations with popularity for perceived popular girls and boys who were liked and not well-liked. Found…

Fuel oil and kerosene sales 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-09-27

This publication contains the 1994 survey results of the ``Annual Fuel Oil and Kerosene Sales Report`` (Form EIA-821). This is the sixth year that the survey data have appeared in a separate publication. Prior to the 1989 report, the statistics appeared in the Petroleum Marketing Annual (PMA)for reference year 1988 and the Petroleum Marketing Monthly (PMM) for reference years 1984 through 1987. The 1994 edition marks the 11th annual presentation of the results of the ongoing ``Annual Fuel Oil and Kerosene Sales Report`` survey. Distillate and residual fuel oil sales continued to move in opposite directions during 1994. Distillate salesmore » rose for the third year in a row, due to a growing economy. Residual fuel oil sales, on the other hand, declined for the sixth year in a row, due to competitive natural gas prices, and a warmer heating season than in 1993. Distillate fuel oil sales increased 4.4 percent while residual fuel oil sales declined 1.6 percent. Kerosene sales decreased 1.4 percent in 1994.« less

A simple Gateway-assisted construction system of TALEN genes for plant genome editing.

PubMed

Kusano, Hiroaki; Onodera, Hitomi; Kihira, Miho; Aoki, Hiromi; Matsuzaki, Hikaru; Shimada, Hiroaki

2016-07-25

TALEN is an artificial nuclease being applied for sequence-specific genome editing. For the plant genome editing, a pair of TALEN genes is expressed in the cells, and a binary plasmid for Agrobacterium-mediated transformation should be assembled. We developed a novel procedure using the Gateway-assisted plasmids, named Emerald-Gateway TALEN system. We constructed entry vectors, pPlat plasmids, for construction of a desired TALEN gene using Platinum Gate TALEN kit. We also created destination plasmid, pDual35SGw1301, which allowed two TALEN genes to both DNA strands to recruit using Gateway technology. Resultant TALEN genes were evaluated by the single-strand annealing (SSA) assay in E. coli cells. By this assay, the TALENs recognized the corresponding targets in the divided luciferase gene, and induced a specific recombination to generate an active luciferase gene. Using the TALEN genes constructed, we created a transformant potato cells in which a site-specific mutation occurred at the target site of the GBSS gene. This suggested that our system worked effectively and was applicable as a convenient tool for the plant genome editing.

Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

PubMed

Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

2011-03-01

Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

A Process Approach to Literacy Using Dialogue Journals and Literature Logs with Second Language Learners.

ERIC Educational Resources Information Center

Reyes, Maria de la Luz

1991-01-01

Examines the ability of 10 sixth grade Hispanic bilingual students to construct meaning in dialogue journals and literature logs in their first and second languages. Finds that students are more effective in constructing meaning in dialogue journals than in literature logs. (MG)

Assessing Knowledge of Mathematical Equivalence: A Construct-Modeling Approach

ERIC Educational Resources Information Center

Rittle-Johnson, Bethany; Matthews, Percival G.; Taylor, Roger S.; McEldoon, Katherine L.

2011-01-01

Knowledge of mathematical equivalence, the principle that 2 sides of an equation represent the same value, is a foundational concept in algebra, and this knowledge develops throughout elementary and middle school. Using a construct-modeling approach, we developed an assessment of equivalence knowledge. Second through sixth graders (N = 175)…

Construct Validity of the Kaufman Brief Intelligence Test, Wechsler Intelligence Scale for Children-Third Edition, and Adjustment Scales for Children and Adolescents

ERIC Educational Resources Information Center

Canivez, Gary L.; Neitzel, Ryan; Martin, Blake E.

2005-01-01

The present study reports data supporting the construct validity of the Kaufman Brief Intelligence Test (K-BIT; Kaufman & Kaufman, 1990), the Wechsler Intelligence Scale for Children-Third Edition (WISC-III; Wechsler, 1991), and the Adjustment Scales for Children and Adolescents (ASCA; McDermott, Marston, & Stott, 1993) through convergent…

Joint Confirmatory Factor Analysis of the Woodcock-Johnson Tests of Cognitive Abilities, Third Edition, and the Stanford-Binet Intelligence Scales, Fifth Edition, with a Preschool Population

ERIC Educational Resources Information Center

Chang, Mei; Paulson, Sharon E.; Finch, W. Holmes; Mcintosh, David E.; Rothlisberg, Barbara A.

2014-01-01

This study examined the underlying constructs measured by the Woodcock-Johnson Tests of Cognitive Abilities, Third Edition (WJ-III COG) and the Stanford-Binet Intelligence Scales, Fifth Edition (SB5), based on the Cattell-Horn-Carrol (CHC) theory of cognitive abilities. This study reports the results of the first joint confirmatory factor analysis…

Colorimetric analysis of three editions of the Velhagen-Broschmann pseudoisochromatic colour plates.

PubMed

Kuchenbecker, Jörn; Nicklas, Sven; Behrens-Baumann, Wolfgang

2010-01-01

Chromatic variations across different copies and different editions of pseudoisochromatic tests and violation of underlying principles of construction for individual plates can influence test results. We analysed the colorimetric characteristics of three different editions of Velhagen-Broschmann pseudoisochromatic plates (30th edition printed in 1995, 31st edition printed in 1997, 32nd edition printed in 2000). One hundred and twelve coloured dots of 18 plates were chosen from each edition. We measured RGB and CIE XYZ values using a spectrophotometer. Differences in lightness and chromaticity between corresponding dots of different editions were analysed in terms of Delta L* and Delta u'v', respectively. For each plate deviations from dichromatic confusion lines were analysed. Furthermore, we determined the relative luminance of a target compared to its background in terms of the Weber contrast. The mean Delta L* across editions was 2.05 (+/-1.4) and the mean Delta u'v' was 0.0078 (+/-0.0029). For two plates the deviations of targets from dichromatic confusion lines exceeded suggested values. For a number of plates, the lightness contrast between the symbol and its background was high. Comparison with psychophysical data showed that these colour plates are easily detectable by colour-deficient observers. Lightness and chromatic variation across the three editions was moderate except for a small number of plates perhaps due to inaccuracies in the printing process. The design of several plates should be revised according to standard principles of construction of colour deficiency tests. (c) 2009 S. Karger AG, Basel.

Units Coordination and the Construction of Improper Fractions: A Revision of the Splitting Hypothesis

ERIC Educational Resources Information Center

Hackenberg, Amy J.

2007-01-01

This article communicates findings from a year-long constructivist teaching experiment about the relationship between four sixth-grade students' multiplicative structures and their construction of improper fractions. Students' multiplicative structures are the units coordinations that they can take as given prior to activity--i.e., the units…

Flaws in Flynn Effect Research with the Wechsler Scales

ERIC Educational Resources Information Center

Weiss, Lawrence G.; Gregoire, Jacques; Zhu, Jianjun

2016-01-01

Many Flynn effect (FE) studies compare scores across different editions of Wechsler's IQ tests. When construct changes are introduced by the test developers in the new edition, however, the presumed generational effects are difficult to untangle from changes due to test content. To remove this confound, we use the same edition of Wechsler…

An automated system for terrain database construction

NASA Technical Reports Server (NTRS)

Johnson, L. F.; Fretz, R. K.; Logan, T. L.; Bryant, N. A.

1987-01-01

An automated Terrain Database Preparation System (TDPS) for the construction and editing of terrain databases used in computerized wargaming simulation exercises has been developed. The TDPS system operates under the TAE executive, and it integrates VICAR/IBIS image processing and Geographic Information System software with CAD/CAM data capture and editing capabilities. The terrain database includes such features as roads, rivers, vegetation, and terrain roughness.

Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-to-inosine RNA editing

PubMed Central

Fukuda, Masatora; Kurihara, Kei; Yamaguchi, Shota; Oyama, Yui; Deshimaru, Masanobu

2014-01-01

Adenosine-to-inosine (A-to-I) RNA editing is an endogenous regulatory mechanism involved in various biological processes. Site-specific, editing-state–dependent degradation of target RNA may be a powerful tool both for analyzing the mechanism of RNA editing and for regulating biological processes. Previously, we designed an artificial hammerhead ribozyme (HHR) for selective, site-specific RNA cleavage dependent on the A-to-I RNA editing state. In the present work, we developed an improved strategy for constructing a trans-acting HHR that specifically cleaves target editing sites in the adenosine but not the inosine state. Specificity for unedited sites was achieved by utilizing a sequence encoding the intrinsic cleavage specificity of a natural HHR. We used in vitro selection methods in an HHR library to select for an extended HHR containing a tertiary stabilization motif that facilitates HHR folding into an active conformation. By using this method, we successfully constructed highly active HHRs with unedited-specific cleavage. Moreover, using HHR cleavage followed by direct sequencing, we demonstrated that this ribozyme could cleave serotonin 2C receptor (HTR2C) mRNA extracted from mouse brain, depending on the site-specific editing state. This unedited-specific cleavage also enabled us to analyze the effect of editing state at the E and C sites on editing at other sites by using direct sequencing for the simultaneous quantification of the editing ratio at multiple sites. Our approach has the potential to elucidate the mechanism underlying the interdependencies of different editing states in substrate RNA with multiple editing sites. PMID:24448449

The Health of the Public Charter School Movement: A State-by-State Analysis. Second Edition

ERIC Educational Resources Information Center

Ziebarth, Todd; Bierlein Palmer, Louann

2016-01-01

In October 2014, the first edition of "The Health of the Public Charter School Movement: A State-by-State Analysis" was released. Both encouraging words and constructive criticism for how to improve the report going forward were received. This second edition builds on the solid foundation of the inaugural version, while making…

Using Written Work to Investigate Stages in Sixth-Grade Students' Construction and Coordination of Units

ERIC Educational Resources Information Center

Ulrich, Catherine; Wilkins, Jesse L. M.

2017-01-01

Background: Students' ability to construct and coordinate units has been found to have far-reaching implications for their ability to develop sophisticated understandings of key middle-grade mathematical topics such as fractions, ratios, proportions, and algebra, topics that form the base of understanding for most STEM-related fields. Most of the…

Environmental Studies. The Construction of an 'A' Level Syllabus.

ERIC Educational Resources Information Center

Carson, S. McB.

In response to the increasing social concern for the quality of the environment and its conservation, and the need to ensure that all pupils in their final years of schooling be brought to share that concern, teachers in Hertfordshire, England, have constructed an 'A' level curriculum or syllabus of environmental studies for the sixth form. Based…

76 FR 20287 - No Child Left Behind School Facilities and Construction Negotiated Rulemaking Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs 25 CFR Chapter I No Child Left Behind School... Indian Affairs is announcing that the No Child Left Behind School Facilities and Construction Negotiated Rulemaking Committee will hold its sixth meeting in Albuquerque, New Mexico. The purpose of the meeting is to...

Construct Validity of the Wechsler Intelligence Scale for Children-Fourth UK Edition with a Referred Irish Sample: Wechsler and Cattell-Horn-Carroll Model Comparisons with 15 Subtests

ERIC Educational Resources Information Center

Canivez, Gary L.; Watkins, Marley W.; Good, Rebecca; James, Kate; James, Trevor

2017-01-01

Background: Irish educational psychologists frequently use the Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004, Wechsler Intelligence Scale for Children-Fourth UK Edition, London, UK, Harcourt Assessment) in clinical assessments of children with learning difficulties. Unfortunately, reliability…

241-AP Tank Farm Construction Extent of Condition Review for Tank Integrity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnes, Travis J.; Gunter, Jason R.; Reeploeg, Gretchen E.

2014-04-04

This report provides the results of an extent of condition construction history review for the 241-AP tank farm. The construction history of the 241-AP tank farm has been reviewed to identify issues similar to those experienced during tank AY-102 construction. Those issues and others impacting integrity are discussed based on information found in available construction records, using tank AY-102 as the comparison benchmark. In the 241-AP tank farm, the sixth double-shell tank farm constructed, tank bottom flatness, refractory material quality, post-weld stress relieving, and primary tank bottom weld rejection were improved.

Raising voices: How sixth graders construct authority and knowledge in argumentative essays

NASA Astrophysics Data System (ADS)

Monahan, Mary Elizabeth

This qualitative classroom-based study documents one teacher-researcher's response to the "voice" debate in composition studies and to the opposing views expressed by Elbow and Bartholomae. The author uses Bakhtin's principle of dialogism, Hymes's theory of communicative competence, as well as Ivanic's discussion of discoursally constructed identities to reconceptualize voice and to redesign writing instruction in her sixth grade classroom. This study shows how students, by redefining and then acting on that voice pedagogy in terms that made sense to them, shaped the author's understanding of what counts as "voiced" writing in non-narrative discourse. Based on a grounded-theory analysis of the twenty-six sixth graders' argumentative essays in science, the author explains voice, not as a property of writers or of texts, but as a process of "knowing together"---a collaborative, but not entirely congenial, exercise of establishing one's authority by talking with, against, and through other voices on the issue. As the results of this study show, the students' "I-Ness" or authorial presence within their texts, was born in a nexus of relationships with "rivals," "allies" and "readers." Given their teacher's injunctions to project confidence and authority in argumentative writing, the students assumed fairly adversarial stances toward these conversational partners throughout their essays. Exaggerating the terms for voiced writing built into the curriculum, the sixth graders produced essays that read more like caricatures than examples of argumentation. Their displays of rhetorical bravado and intellectual aggressiveness, however offsetting to the reader, still enabled these sixth graders to composed voiced essays. This study raises doubts about the value of urging students to sound like their "true selves" or to adopt the formal registers of academe. Students, it seems clear, stand to gain by experimenting with a range of textual identities. The author suggests that voice, as a dialogic process, involves a struggle for meaning---in concert, but also very much in conflict with---other speakers and their intentions.

Students' Whole Number Multiplicative Concepts: A Critical Constructive Resource for Fraction Composition Schemes

ERIC Educational Resources Information Center

Hackenberg, Amy J.; Tillema, Erik S.

2009-01-01

This article reports on the activity of two pairs of sixth grade students who participated in an 8-month teaching experiment that investigated the students' construction of fraction composition schemes. A fraction composition scheme consists of the operations and concepts used to determine, for example, the size of 1/3 of 1/5 of a whole in…

2002 Construction manual

DOT National Transportation Integrated Search

2002-01-01

The Illinois Department of Transportation's Highway Construction Manual has been updated from its previous version. All previous editions of this manual are now obsolete and changes in content have been marked. The Construction Manual provides inform...

Non-Linear Editing for the Smaller College-Level Production Program, Rev. 2.0.

ERIC Educational Resources Information Center

Tetzlaff, David

This paper focuses on a specific topic and contention: Non-linear editing earns its place in a liberal arts setting because it is a superior tool to teach the concepts of how moving picture discourse is constructed through editing. The paper first points out that most students at small liberal arts colleges are not going to wind up working…

The Cognitive Abilities Scale--Second Edition Preschool Form: Studies of Concurrent Criterion-Related, Construct, and Predictive Criterion-Related Validity

ERIC Educational Resources Information Center

Swanson, Jennifer R.; Bradley-Johnson, Sharon; Johnson, C. Merle; O'Dell, Anna Rubenaker

2009-01-01

Three studies examine the validity of the Preschool Form of the Cognitive Abilities Scale--Second Edition (CAS-2). Significant high concurrent criterion-related validity correlations, corrected for restricted range, are found between the CAS-2 and the Detroit Test of Learning Ability--Primary: Third Edition for 26 three-year-olds (r[subscript c] =…

Targeted ENO schemes with tailored resolution property for hyperbolic conservation laws

NASA Astrophysics Data System (ADS)

Fu, Lin; Hu, Xiangyu Y.; Adams, Nikolaus A.

2017-11-01

In this paper, we extend the range of targeted ENO (TENO) schemes (Fu et al. (2016) [18]) by proposing an eighth-order TENO8 scheme. A general formulation to construct the high-order undivided difference τK within the weighting strategy is proposed. With the underlying scale-separation strategy, sixth-order accuracy for τK in the smooth solution regions is designed for good performance and robustness. Furthermore, a unified framework to optimize independently the dispersion and dissipation properties of high-order finite-difference schemes is proposed. The new framework enables tailoring of dispersion and dissipation as function of wavenumber. The optimal linear scheme has minimum dispersion error and a dissipation error that satisfies a dispersion-dissipation relation. Employing the optimal linear scheme, a sixth-order TENO8-opt scheme is constructed. A set of benchmark cases involving strong discontinuities and broadband fluctuations is computed to demonstrate the high-resolution properties of the new schemes.

Fundamentals of Construction. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in the fundamentals of construction to students who have chosen to explore careers in construction. The following topics are covered in the course's 10 instructional units: industry orientation (exploring the construction industry and starting a…

Mojo Hand, a TALEN design tool for genome editing applications.

PubMed

Neff, Kevin L; Argue, David P; Ma, Alvin C; Lee, Han B; Clark, Karl J; Ekker, Stephen C

2013-01-16

Recent studies of transcription activator-like (TAL) effector domains fused to nucleases (TALENs) demonstrate enormous potential for genome editing. Effective design of TALENs requires a combination of selecting appropriate genetic features, finding pairs of binding sites based on a consensus sequence, and, in some cases, identifying endogenous restriction sites for downstream molecular genetic applications. We present the web-based program Mojo Hand for designing TAL and TALEN constructs for genome editing applications (http://www.talendesign.org). We describe the algorithm and its implementation. The features of Mojo Hand include (1) automatic download of genomic data from the National Center for Biotechnology Information, (2) analysis of any DNA sequence to reveal pairs of binding sites based on a user-defined template, (3) selection of restriction-enzyme recognition sites in the spacer between the TAL monomer binding sites including options for the selection of restriction enzyme suppliers, and (4) output files designed for subsequent TALEN construction using the Golden Gate assembly method. Mojo Hand enables the rapid identification of TAL binding sites for use in TALEN design. The assembly of TALEN constructs, is also simplified by using the TAL-site prediction program in conjunction with a spreadsheet management aid of reagent concentrations and TALEN formulation. Mojo Hand enables scientists to more rapidly deploy TALENs for genome editing applications.

About crystal lattices and quasilattices in Euclidean space

NASA Astrophysics Data System (ADS)

Prokhoda, A. S.

2017-07-01

Definitions are given, based on which algorithms have been developed for constructing computer models of two-dimensional quasilattices and the corresponding quasiperiodic tilings in plane, the point symmetry groups of which are dihedral groups D m ( m = 5, 7, 8, 9, 10, 12, 14, 18), and the translation subgroups are free Abelian groups of the fourth or sixth rank. The angles at the tile vertices in the constructed tilings are calculated.

ONSITE WASTEWATER TREATMENT AND DISPOSAL SYSTEMS (1980 EDITION) AND ONSITE WASTEWATER TREATMENT SYSTEMS MANUAL (2002 EDITION)

EPA Science Inventory

The U.S. Environmental Protection Agency (USEPA) first issued detailed guidance on the design, construction, and operation of onsite wastewater treatment systems (OWTSs) in 1980. Design Manual: Onsite Wastewater Treatment and Disposal Systems (USEPA.1980) was the most comprehens...

Contribution of High-Order Rainbows to the Scattering of a Gaussian Laser Beam by a Spherical Particle

NASA Technical Reports Server (NTRS)

Lock, James A.

1993-01-01

I review the theory of the scattering of a Gaussian laser beam by a dielectric spherical particle and give the details for constructing a computer program to implement the theory. Computational results indicate that if the width of the laser beam is much less than the diameter of the particle and if the axis of the beam is incident near the edge of the particle, the fifth-, sixth-, and ninth-order rainbows should be evident in the far-field scattered intensity. I performed an experiment that yielded tentative evidence for the presence of the sixth- order rainbow.

38 CFR 39.63 - Architectural design standards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Association Life Safety Code and Errata (NFPA 101), the 2003 edition of the NFPA 5000, Building Construction... section, all applicable local and State building codes and regulations must be observed. In areas not subject to local or State building codes, the recommendations contained in the 2003 edition of the NFPA...

Improving the readability of online foot and ankle patient education materials.

PubMed

Sheppard, Evan D; Hyde, Zane; Florence, Mason N; McGwin, Gerald; Kirchner, John S; Ponce, Brent A

2014-12-01

Previous studies have shown the need for improving the readability of many patient education materials to increase patient comprehension. This study's purpose was to determine the readability of foot and ankle patient education materials and to determine the extent readability can be improved. We hypothesized that the reading levels would be above the recommended guidelines and that decreasing the sentence length would also decrease the reading level of these patient educational materials. Patient education materials from online public sources were collected. The readability of these articles was assessed by a readability software program. The detailed instructions provided by the National Institutes of Health (NIH) were then used as a guideline for performing edits to help improve the readability of selected articles. The most quantitative guideline, lowering all sentences to less than 15 words, was chosen to show the effect of following the NIH recommendations. The reading levels of the sampled articles were above the sixth to seventh grade recommendations of the NIH. The MedlinePlus website, which is a part of the NIH website, had the lowest reading level (8.1). The articles edited had an average reduction of 1.41 grade levels, with the lowest reduction in the Medline articles of 0.65. Providing detailed instructions to the authors writing these patient education articles and implementing editing techniques based on previous recommendations could lead to an improvement in the readability of patient education materials. This study provides authors of patient education materials with simple editing techniques that will allow for the improvement in the readability of online patient educational materials. The improvement in readability will provide patients with more comprehendible education materials that can strengthen patient awareness of medical problems and treatments. © The Author(s) 2014.

Sequence-Based Mapping and Genome Editing Reveal Mutations in Stickleback Hps5 Cause Oculocutaneous Albinism and the casper Phenotype.

PubMed

Hart, James C; Miller, Craig T

2017-09-07

Here, we present and characterize the spontaneous X-linked recessive mutation casper , which causes oculocutaneous albinism in threespine sticklebacks ( Gasterosteus aculeatus ). In humans, Hermansky-Pudlak syndrome results in pigmentation defects due to disrupted formation of the melanin-containing lysosomal-related organelle (LRO), the melanosome. casper mutants display not only reduced pigmentation of melanosomes in melanophores, but also reductions in the iridescent silver color from iridophores, while the yellow pigmentation from xanthophores appears unaffected. We mapped casper using high-throughput sequencing of genomic DNA from bulked casper mutants to a region of the stickleback X chromosome (chromosome 19) near the stickleback ortholog of Hermansky-Pudlak syndrome 5 ( Hps5 ). casper mutants have an insertion of a single nucleotide in the sixth exon of Hps5 , predicted to generate an early frameshift. Genome editing using CRISPR/Cas9 induced lesions in Hps5 and phenocopied the casper mutation. Injecting single or paired Hps5 guide RNAs revealed higher incidences of genomic deletions from paired guide RNAs compared to single gRNAs. Stickleback Hps5 provides a genetic system where a hemizygous locus in XY males and a diploid locus in XX females can be used to generate an easily scored visible phenotype, facilitating quantitative studies of different genome editing approaches. Lastly, we show the ability to better visualize patterns of fluorescent transgenic reporters in Hps5 mutant fish. Thus, Hps5 mutations present an opportunity to study pigmented LROs in the emerging stickleback model system, as well as a tool to aid in assaying genome editing and visualizing enhancer activity in transgenic fish. Copyright © 2017 Hart and Milller.

Investigating the Effects of the Classroom Learning Environment on Students' Motivation in Social Studies.

ERIC Educational Resources Information Center

Knight, Stephanie L.; Waxman, Hersholt C.

1990-01-01

Investigates the relationship between social studies classroom environment and student motivation. Correlates several environmental variables with three motivational constructs (academic motivation, academic self-concept, and social self-concept) among 157 sixth grade, predominantly Hispanic students. Finds student satisfaction significantly…

Introduction to Construction Welding. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in construction welding to students who have chosen to explore careers in construction. It contains three units: welding materials, welding tools, and applied skills. Each instructional unit includes some or all of the basic components of a unit…

Construct Validity of Selected Measures of Physical Activity Beliefs and Motives in Fifth and Sixth Grade Boys and Girls

PubMed Central

Saunders, Ruth P.; McIver, Kerry L.; Dowda, Marsha; Pate, Russell R.

2013-01-01

Objective Scales used to measure selected social-cognitive beliefs and motives for physical activity were tested among boys and girls. Methods Covariance modeling was applied to responses obtained from large multi-ethnic samples of students in the fifth and sixth grades. Results Theoretically and statistically sound models were developed, supporting the factorial validity of the scales in all groups. Multi-group longitudinal invariance was confirmed between boys and girls, overweight and normal weight students, and non-Hispanic black and white children. The construct validity of the scales was supported by hypothesized convergent and discriminant relationships within a measurement model that included correlations with physical activity (MET • min/day) measured by an accelerometer. Conclusions Scores from the scales provide valid assessments of selected beliefs and motives that are putative mediators of change in physical activity among boys and girls, as they begin the understudied transition from the fifth grade into middle school, when physical activity naturally declines. PMID:23459310

Construct validity of selected measures of physical activity beliefs and motives in fifth and sixth grade boys and girls.

PubMed

Dishman, Rod K; Saunders, Ruth P; McIver, Kerry L; Dowda, Marsha; Pate, Russell R

2013-06-01

Scales used to measure selected social-cognitive beliefs and motives for physical activity were tested among boys and girls. Covariance modeling was applied to responses obtained from large multi-ethnic samples of students in the fifth and sixth grades. Theoretically and statistically sound models were developed, supporting the factorial validity of the scales in all groups. Multi-group longitudinal invariance was confirmed between boys and girls, overweight and normal weight students, and non-Hispanic black and white children. The construct validity of the scales was supported by hypothesized convergent and discriminant relationships within a measurement model that included correlations with physical activity (MET • min/day) measured by an accelerometer. Scores from the scales provide valid assessments of selected beliefs and motives that are putative mediators of change in physical activity among boys and girls, as they begin the understudied transition from the fifth grade into middle school, when physical activity naturally declines.

Sixth- and eighth-order Hermite integrator for N-body simulations

NASA Astrophysics Data System (ADS)

Nitadori, Keigo; Makino, Junichiro

2008-10-01

We present sixth- and eighth-order Hermite integrators for astrophysical N-body simulations, which use the derivatives of accelerations up to second-order ( snap) and third-order ( crackle). These schemes do not require previous values for the corrector, and require only one previous value to construct the predictor. Thus, they are fairly easy to implement. The additional cost of the calculation of the higher-order derivatives is not very high. Even for the eighth-order scheme, the number of floating-point operations for force calculation is only about two times larger than that for traditional fourth-order Hermite scheme. The sixth-order scheme is better than the traditional fourth-order scheme for most cases. When the required accuracy is very high, the eighth-order one is the best. These high-order schemes have several practical advantages. For example, they allow a larger number of particles to be integrated in parallel than the fourth-order scheme does, resulting in higher execution efficiency in both general-purpose parallel computers and GRAPE systems.

49 CFR 171.7 - Reference material.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., 1988, into § 174.55; 174.63. (3) AAR Specifications for Design, Fabrication and Construction of Freight... Edition), into § 172.400a. (8) CGA Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design... Compressed Gas Cylinders at Time of Manufacture, 2001, Third Edition, into § 178.35. (10) CGA Pamphlet C-12...

The Third Edition of the Test of Understanding in College Economics.

ERIC Educational Resources Information Center

Saunders, Phillip

1991-01-01

Discusses the content and cognitive specification of the third edition of the Test of Understanding in College Economics. Presents examples of the construction and sampling criteria employed in the latest and previous versions of the test. Explains that the test emphasizes recognition and understanding of basic terms, concepts, and principles with…

Baculovirus-based genome editing in primary cells.

PubMed

Mansouri, Maysam; Ehsaei, Zahra; Taylor, Verdon; Berger, Philipp

2017-03-01

Genome editing in eukaryotes became easier in the last years with the development of nucleases that induce double strand breaks in DNA at user-defined sites. CRISPR/Cas9-based genome editing is currently one of the most powerful strategies. In the easiest case, a nuclease (e.g. Cas9) and a target defining guide RNA (gRNA) are transferred into a target cell. Non-homologous end joining (NHEJ) repair of the DNA break following Cas9 cleavage can lead to inactivation of the target gene. Specific repair or insertion of DNA with Homology Directed Repair (HDR) needs the simultaneous delivery of a repair template. Recombinant Lentivirus or Adenovirus genomes have enough capacity for a nuclease coding sequence and the gRNA but are usually too small to also carry large targeting constructs. We recently showed that a baculovirus-based multigene expression system (MultiPrime) can be used for genome editing in primary cells since it possesses the necessary capacity to carry the nuclease and gRNA expression constructs and the HDR targeting sequences. Here we present new Acceptor plasmids for MultiPrime that allow simplified cloning of baculoviruses for genome editing and we show their functionality in primary cells with limited life span and induced pluripotent stem cells (iPS). Copyright © 2017 Elsevier Inc. All rights reserved.

7 CFR 1942.18 - Community facilities-Planning, bidding, contracting, constructing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... which will contribute to the preservation and enhancement of sites, structures, and objects of...-96-1, “Guidelines for Construction and Equipment of Hospital and Medical Facilities,” 1987 Edition.... Owners may accomplish construction by using their own personnel and equipment provided the owners possess...

[Genome editing of industrial microorganism].

PubMed

Zhu, Linjiang; Li, Qi

2015-03-01

Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

Fundamentals of Construction. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide begins the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in mind. This guide contains 3 sections and 15…

Keys to soil taxonomy by soil survey staff (sixth edition)

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-12-31

This publication, Keys to Soil Taxonomy, serves two purposes. It provides the taxonomic keys necessary for the classification of soils according to Soil Taxonomy in a form that can be used easily in the field, and it also acquaints users of Soil Taxonomy with recent changes in the classification system. This volume includes all revisions of the keys that have so far been approved, replacing the original keys in Soil Taxonomy: A Basic System of Soil Classification for Making and Interpreting Soil Surveys (1975), the work on which this abridged version, first published in 1983, is based. This publication incorporatesmore » all amendments approved to date and published in National Soil Taxonomy Handbook (NSTH) Issues 1-17.« less

RNA editing site recognition in heterologous plant mitochondria.

PubMed

Choury, David; Araya, Alejandro

2006-12-01

RNA editing is a process that modifies the information content of mitochondrial messenger RNAs in flowering plants changing specific cytosine residues into uridine. To gain insight into editing site recognition, we used electroporation to introduce engineered wheat (Triticum aestivum) or potato (Solanum tuberosum) mitochondrial cox2 genes, and an atp9-containing chimeric gene, into non-cognate mitochondria, and observed the efficiency of editing in these contexts. Both wheat and potato mitochondria were able to express "foreign" constructs, and their products were properly spliced. Seventeen and twelve editing sites are present in the coding regions of wheat and potato cox2 transcripts, respectively. Eight are common to both plants, whereas nine are specific to wheat, and four to potato. An analogous situation is found for the atp9 mRNA coding regions from these species. We found that both mitochondria were able to recognize sites that are already present as T at the genomic level, making RNA editing unnecessary for that specific residue in the cognate organelle. Our results demonstrate that non-cognate mitochondria are able to edit residues that are not edited in their own transcripts, and support the hypothesis that the same trans-acting factor may recognize several editing sites.

Making Toys through Teamwork.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. Center for Vocational and Technical Education.

The guide is designed to engage fifth and sixth grade students in learning experiences intended to acquaint them with wood construction and mass production. In addition to developing carpentry skills, students learn the safe use of tools, equipment, and materials. While simulating a toy company, they inductively develop processes for the mass…

General Physics as a Major

ERIC Educational Resources Information Center

Peckham, Donald C.; Romer, Alfred

1976-01-01

A three-year general physics program which uses a single text from which a sequence of one-year courses have been constructed is described. It is organized on a modified spiral approach and requires laboratory work culminating in an experimental project during the sixth semester. Discussion includes implementation and administration of the…

Becoming Something Different: Learning from Esme

ERIC Educational Resources Information Center

Fairbanks, Colleen M.; Crooks, Penny Mason; Ariail, Mary

2011-01-01

In this article, Fairbanks, Crooks, and Ariail followed Esme Martinez, a Spanish-speaking Latina, from the sixth grade to the eleventh grade, focusing on her perspectives of schooling and her shifting identities related to home, school, friendships, and future. Drawing on the construct of artifacts, a sociohistorical concept that understands…

Tessellating with Logo: Effects on Visual Literacy.

ERIC Educational Resources Information Center

Knupfer, Nancy Nelson; Clark, Barbara I.

This investigation of the potential of a Logo environment to develop visual literacy skills in elementary school students focused on the recognition of Escher-type geometric constructions by second and sixth grade students. Four research questions were addressed: (1) whether students can use higher-order and creative thinking skills in using…

Woodworking & housing: impacts & actions

Treesearch

Matt Bumgardner; Urs Buehlmann; Karen Koenig

2015-01-01

The woodworking industry relies heavily on the construction-based markets, particularly those companies involved in cabinetry, furniture, millwork and components. Market conditions, trends and investments all have an impact. It's against this backdrop, that the sixth annual housing market study was conducted in early 2015. A joint effort by Virginia Tech, the U.S...

Constructing a Coherent Problem Model to Facilitate Algebra Problem Solving in a Chemistry Context

ERIC Educational Resources Information Center

Ngu, Bing Hiong; Yeung, Alexander Seeshing; Phan, Huy P.

2015-01-01

An experiment using a sample of 11th graders compared text editing and worked examples approaches in learning to solve dilution and molarity algebra word problems in a chemistry context. Text editing requires students to assess the structure of a word problem by specifying whether the problem text contains sufficient, missing, or irrelevant…

Algebra Word Problem Solving Approaches in a Chemistry Context: Equation Worked Examples versus Text Editing

ERIC Educational Resources Information Center

Ngu, Bing Hiong; Yeung, Alexander Seeshing

2013-01-01

Text editing directs students' attention to the problem structure as they classify whether the texts of word problems contain sufficient, missing or irrelevant information for working out a solution. Equation worked examples emphasize the formation of a coherent problem structure to generate a solution. Its focus is on the construction of three…

Construct Validity Evidence for Bracken School Readiness Assessment, Third Edition, Spanish Form Scores

ERIC Educational Resources Information Center

Ortiz, Arlene; Clinton, Amanda; Schaefer, Barbara A.

2015-01-01

Convergent and discriminant validity evidence was examined for scores on the Spanish Record Form of the Bracken School Readiness Assessment, Third Edition (BSRA-3). Participants included a sample of 68 Hispanic, Spanish-speaking children ages 4 to 5 years enrolled in preschool programs in Puerto Rico. Scores obtained from the BSRA-3 Spanish Record…

Generation of Stable Knockout Mammalian Cells by TALEN-Mediated Locus-Specific Gene Editing.

PubMed

Mahata, Barun; Biswas, Kaushik

2017-01-01

Precise and targeted genome editing using Transcription Activator-Like Effector Endonucleases (TALENs) has been widely used and proven to be an extremely effective and specific knockout strategy in both cultured cells and animal models. The current chapter describes a protocol for the construction and generation of TALENs using serial and hierarchical digestion and ligation steps, and using the synthesized TALEN pairs to achieve locus-specific targeted gene editing in mammalian cell lines using a modified clonal selection strategy in an easy and cost-efficient manner.

Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice.

PubMed

Shen, Lan; Hua, Yufeng; Fu, Yaping; Li, Jian; Liu, Qing; Jiao, Xiaozhen; Xin, Gaowei; Wang, Junjie; Wang, Xingchun; Yan, Changjie; Wang, Kejian

2017-05-01

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease 9 (CRISPR/Cas9) system has emerged as a promising technology for specific genome editing in many species. Here we constructed one vector targeting eight agronomic genes in rice using the CRISPR/Cas9 multiplex genome editing system. By subsequent genetic transformation and DNA sequencing, we found that the eight target genes have high mutation efficiencies in the T 0 generation. Both heterozygous and homozygous mutations of all editing genes were obtained in T 0 plants. In addition, homozygous sextuple, septuple, and octuple mutants were identified. As the abundant genotypes in T 0 transgenic plants, various phenotypes related to the editing genes were observed. The findings demonstrate the potential of the CRISPR/Cas9 system for rapid introduction of genetic diversity during crop breeding.

Some Considerations in Maintaining Adaptive Test Item Pools.

ERIC Educational Resources Information Center

Stocking, Martha L.

The construction of parallel editions of conventional tests for purposes of test security while maintaining score comparability has always been a recognized and difficult problem in psychometrics and test construction. The introduction of new modes of test construction, e.g., adaptive testing, changes the nature of the problem, but does not make…

Cusp-Gun Sixth-Harmonic Slotted Gyrotron

NASA Astrophysics Data System (ADS)

Stutzman, R. C.; McDermott, D. B.; Hirata Luhmann, Y., Jr.; Gallagher, D. A.; Spencer, T. A.

2000-10-01

A high-harmonic slotted gyrotron has been constructed at UC Davis to be driven by a 70 kV, 3.5 A, axis-encircling electron beam from a Northrop Grumman Cusp gun. The 94 GHz, slotted sixth-harmonic gyrotron is predicted to generate 50 kW with an efficiency of 20%. Using the profile of the adiabatic field reversal from the UC Davis superconducting test-magnet, EGUN simulations predict that an axis-encircling electron beam will be generated with an axial velocity spread of Δ v_z/v_z=10% for the desired velocity ratio of α =v_z/v_z=1.5. The design will also be presented for an 8th-harmonic W-band gyrotron whose magnetic field can be supplied by a lightweight permanent magnet.

Geometric description of a discrete power function associated with the sixth Painlevé equation.

PubMed

Joshi, Nalini; Kajiwara, Kenji; Masuda, Tetsu; Nakazono, Nobutaka; Shi, Yang

2017-11-01

In this paper, we consider the discrete power function associated with the sixth Painlevé equation. This function is a special solution of the so-called cross-ratio equation with a similarity constraint. We show in this paper that this system is embedded in a cubic lattice with [Formula: see text] symmetry. By constructing the action of [Formula: see text] as a subgroup of [Formula: see text], i.e. the symmetry group of P VI , we show how to relate [Formula: see text] to the symmetry group of the lattice. Moreover, by using translations in [Formula: see text], we explain the odd-even structure appearing in previously known explicit formulae in terms of the τ function.

Self-Esteem and Adjusting with Blindness: The Process of Responding to Life's Demands. Third Edition

ERIC Educational Resources Information Center

Tuttle, Dean W.; Tuttle, Naomi R.

2004-01-01

This new and expanded Third Edition analyzes blindness within the context of two overlapping theoretical constructs: the development of self-esteem and the process of adjusting to social and/or physical trauma. The book is divided into four sections. The first section, provides an overview of blindness and the essential background for subsequent…

REQUIREMENTS FOR HAZARDOUS WASTE LANDFILL DESIGN, CONSTRUCTION AND CLOSURE

EPA Science Inventory

This publication contains edited versions of the material presented at ten Technology Transfer seminars conducted in 1988 on this subject. Sections are included on design of clay and flexible membrane liners, leachate collector systems, and landfill covers. Construction quality a...

Collaborative Practice of Science Construction in a Computer-Based Multimedia Environment.

ERIC Educational Resources Information Center

Kumpulainen, Kristiina; Mutanen, Mika

1998-01-01

Examines the ways in which the collaborative use of a multimedia-based CD-ROM encyclopedia in a sixth-grade Finnish classroom fosters science learning. Results show that students' activities during task-processing were highly procedural and product-oriented. Students had inefficient skills in accessing and retrieving information from the…

Parenting the Young Handicapped Child: ECI-6. Early Childhood Intervention Catalog Module.

ERIC Educational Resources Information Center

Evans, Joyce; Bricker, Donna

The sixth of seven monographs on early intervention for young (birth to age 3) handicapped children is intended for parents and other family members. Materials which focus on five topics appropriate for parent groups (overcoming communication barriers, legal rights and responsibility, self concept and their children, toy construction for learning,…

Social Constructivism: Botanical Classification Schemes of Elementary School Children.

ERIC Educational Resources Information Center

Tull, Delena

The assertion that there is a social component to children's construction of knowledge about natural phenomena is supported by evidence from an examination of children's classification schemes for plants. An ethnographic study was conducted with nine sixth grade children in central Texas. The children classified plants in the outdoors, in a…

Environmental Education in Sparsely Populated Areas: Conflicting Attitudes in Student's Conception of Environmental Issues.

ERIC Educational Resources Information Center

Chaib, Mohamed

1988-01-01

Two studies in southeastern Sweden examined rural children's conflicting attitudes toward environmental change in the local community. Following a yearlong curriculum in environmental studies, 14 fifth and sixth graders in Ramkvilla were presented with an imaginary scenario involving the construction of a new factory. Their small, somewhat idyllic…

SCCR Digital Learning System for Scientific Conceptual Change and Scientific Reasoning

ERIC Educational Resources Information Center

She, H. C.; Lee, C. Q.

2008-01-01

This study reports an adaptive digital learning project, scientific concept construction and reconstruction (SCCR), that was developed based on the theories of Dual Situated Learning Model (DSLM) and scientific reasoning. In addition, the authors investigated the effects of an SCCR related to a "combustion" topic for sixth grade students…

Multimodal Teacher Input and Science Learning in a Middle School Sheltered Classroom

ERIC Educational Resources Information Center

Zhang, Ying

2016-01-01

This article reports the results of an ethnographic research about the multimodal science discourse in a sixth-grade sheltered classroom involving English Language Learners (ELLs) only. Drawing from the perspective of multimodality, this study examines how science learning is constructed in science lectures through multiple semiotic resources,…

The Carbon Cycle: Teaching Youth about Natural Resource Sustainability

ERIC Educational Resources Information Center

Warren, William A.

2015-01-01

The carbon cycle was used as a conceptual construct for organizing the curriculum for a youth summer camp on natural resource use and sustainability. Several studies have indicated the importance of non-traditional youth education settings for science education and understanding responsible natural resource use. The Sixth Grade Forestry Tour, a…

World commercial aircraft accidents. Second edition, 1946--1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kimura, C.Y.

1993-01-01

This report is a compilation of all accidents world-wide involving aircraft in commercial service which resulted in the loss of the airframe or one or more fatality, or both. This information has been gathered in order to present a complete inventory of commercial aircraft accidents. Events involving military action, sabotage, terrorist bombings, hijackings, suicides, and industrial ground accidents are included within this list. Included are: accidents involving world commercial jet aircraft, world commercial turboprop aircraft, world commercial pistonprop aircraft with four or more engines and world commercial pistonprop aircraft with two or three engines from 1946 to 1992. Each accidentmore » is presented with information in the following categories: date of the accident, airline and its flight numbers, type of flight, type of aircraft, aircraft registration number, construction number/manufacturers serial number, aircraft damage, accident flight phase, accident location, number of fatalities, number of occupants, cause, remarks, or description (brief) of the accident, and finally references used. The sixth chapter presents a summary of the world commercial aircraft accidents by major aircraft class (e.g. jet, turboprop, and pistonprop) and by flight phase. The seventh chapter presents several special studies including a list of world commercial aircraft accidents for all aircraft types with 100 or more fatalities in order of decreasing number of fatalities, a list of collision accidents involving commercial aircrafts, and a list of world commercial aircraft accidents for all aircraft types involving military action, sabotage, terrorist bombings, and hijackings.« less

Validity aspects of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, narcissistic personality disorder construct.

PubMed

Karterud, Sigmund; Øien, Maria; Pedersen, Geir

2011-01-01

The Diagnostic and Statistical Manual of Mental Disorders (DSM), Fourth Edition, narcissistic personality disorder (NPD) construct has been criticized for being too narrowly defined, for example, by focusing on overt grandiosity at the expense of exhibitionism and narcissistic vulnerability and thus covering only parts of the domain of narcissism. The purpose of this study was to elucidate several validity aspects of the NPD construct. The material consisted of data from 2277 patients (80% of whom had a personality disorder [PD]) who were admitted to units connected to The Norwegian Network of Psychotherapeutic Day Hospitals. The Axis II diagnoses were assessed by Structured Clinical Interview for DSM, Fourth Edition, Axis II Personality Disorders. The frequency of NPD was very low (0.8%). Male patients were overrepresented both on a diagnostic level and on criteria levels. The NPD category was positively associated with other cluster B disorders and negatively associated with avoidant PD. The criteria "demands excessive admiration" and "fantasies of unlimited success" correlated almost as highly with the histrionic PD category and loaded primarily on a histrionic factor. The dominant NPD factor also included the antisocial criterion of "showing no regret having injured others." The major part of the patients' personality pathology could be attributed to other PD criteria. The results challenge the notion of NPD as a distinct diagnostic category. Rather, narcissism should be conceived as personality dimensions pertinent to the whole range of PDs. The results support the views put forward by Russ et al (Refining the construct of narcissistic personality disorder: diagnostic criteria and subtypes. Am J Psychiatry 2008;11:1473-1481) that what clinicians conceive as narcissism consists of several subtypes (dimensions). Our data support the existence of a grandiose/malignant type and an exhibitionistic type. Unfortunately, there was no measure of hypersensitivity. The proposal to delete NPD as a prototype category in the DSM, Fifth Edition, seems well justified. However, the proposed trait domain of antagonism in the DSM, Fifth Edition, seems to account better for the grandiose/malignant dimension than the exhibitionistic/histrionic dimension. Copyright © 2011 Elsevier Inc. All rights reserved.

POLLUX: a program for simulated cloning, mutagenesis and database searching of DNA constructs.

PubMed

Dayringer, H E; Sammons, S A

1991-04-01

Computer support for research in biotechnology has developed rapidly and has provided several tools to aid the researcher. This report describes the capabilities of new computer software developed in this laboratory to aid in the documentation and planning of experiments in molecular biology. The program, POLLUX, provides a graphical medium for the entry, edit and manipulation of DNA constructs and a textual format for display and edit of construct descriptive data. Program operation and procedures are designed to mimic the actual laboratory experiments with respect to capability and the order in which they are performed. Flexible control over the content of the computer-generated displays and program facilities is provided by a mouse-driven menu interface. Programmed facilities for mutagenesis, simulated cloning and searching of the database from networked workstations are described.

Specifications and Construction Methods for Asphalt Concrete and Other Plant-Mix Types, 3rd Edition.

ERIC Educational Resources Information Center

Asphalt Inst., College Park, MD.

The purpose of this publication is to assist engineers in the analysis, design and control of paving projects that use asphalt concrete and other asphalt plant-mixes. The scope of this new third edition has been enlarged, and changes necessitated by advances in asphalt technology have been incorporated. Chapters I and II and Appendices A and B…

Confirmatory Factor Structure of the Kaufman Assessment Battery for Children-Second Edition with Preschool Children: Too Young for Differentiation?

ERIC Educational Resources Information Center

Potvin, Deborah C. H.; Keith, Timothy Z.; Caemmerer, Jacqueline M.; Trundt, Katherine M.

2015-01-01

With an age range from 3 to 13 years, the Kaufman Assessment Battery for Children-Second Edition (KABC-II) offers an appealing option for the assessment of cognitive abilities for children. Although independent research has provided evidence of the construct validity of the KABC-II for school-age children, previous studies have rarely included an…

38 CFR 39.63 - Architectural design standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 5000, Building Construction and Safety Code, and the 2002 edition of the National Electrical Code, NFPA... 5000, Building Construction and Safety Code. Where the adopted codes state conflicting requirements... the standards set forth in this section, all applicable local and State building codes and regulations...

38 CFR 39.63 - Architectural design standards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 5000, Building Construction and Safety Code, and the 2002 edition of the National Electrical Code, NFPA... 5000, Building Construction and Safety Code. Where the adopted codes state conflicting requirements... the standards set forth in this section, all applicable local and State building codes and regulations...

38 CFR 39.63 - Architectural design standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 5000, Building Construction and Safety Code, and the 2002 edition of the National Electrical Code, NFPA... 5000, Building Construction and Safety Code. Where the adopted codes state conflicting requirements... the standards set forth in this section, all applicable local and State building codes and regulations...

EXPERIMENTAL DEVELOPMENT OF VARIABILITY IN READING RATE IN GRADES FOUR, FIVE AND SIX.

ERIC Educational Resources Information Center

HARRIS, THEODORE L.; AND OTHERS

METHODS OF TESTING, EVALUATING, AND TEACHING READING IN THE FOURTH, FIFTH AND SIXTH GRADES ARE DESCRIBED. CONSTRUCTION AND DESIGN OF EXPERIMENTAL TESTS OF VARIABILITY IN READING SPEED ARE DISCUSSED. DESIGN WAS BASED ON THE RATIONALE THAT A MEANINGFUL READING-TIME SCORE DIRECTLY RELATED TO THE SUBJECT'S PURPOSE FOR READING. WHILE READING SPEED MAY…

Middle Grades Students' Situation Definitions: Development of a Knowledge-Linking Inventory

ERIC Educational Resources Information Center

Schuh, Kathy L.; Kuo, Yi-Lung; Knupp, Tawnya L.

2013-01-01

The purpose of this study was to develop the Student Knowledge Linking Instrument (SKLI), an inventory for middle grades students that seeks to understand student knowledge construction processes. This study included 461 fifth and sixth grade students and follows from a series of qualitative studies that were used as a foundation for development…

Predicting Middle School Students' Use of Web 2.0 Technologies out of School Using Home and School Technological Variables

ERIC Educational Resources Information Center

Hughes, Joan E.; Read, Michelle F.; Jones, Sara; Mahometa, Michael

2015-01-01

This study used multiple regression to identify predictors of middle school students' Web 2.0 activities out of school, a construct composed of 15 technology activities. Three middle schools participated, where sixth- and seventh-grade students completed a questionnaire. Independent predictor variables included three demographic and five computer…

The Construction of Children's Character. Ninety-Sixth Yearbook of the National Society for the Study of Education. Part II.

ERIC Educational Resources Information Center

Molnar, Alex, Ed.

1997-01-01

This book presents a comprehensive and critical assessment of contemporary character education theory and practice from a variety of perspectives: historical, cultural, philosophical, psychological, empirical, political, and ethical. The essays in this book are divided into five sections intended to help develop a well-grounded understanding of…

Factor Analytic Study of Cognitive Processing and Self Perception of Learning Disabilities among the Elementary Inclusive School Children

ERIC Educational Resources Information Center

Rijumol, K. C.; Thangarajathi, S.; Ananthasayanam, R.

2011-01-01

The present investigation was an attempt to explore the underlying construct of cognitive processing and self-perception of learning disabilities in elementary inclusive school children. A cognitive assessment test battery and self-perception of disabilities inventory was developed by the investigator and administered to 100 elementary sixth and…

The Impact of Using Multi-Sensory Approach for Teaching Students with Learning Disabilities

ERIC Educational Resources Information Center

Obaid, Majeda Al Sayyed

2013-01-01

The purpose of this study is to investigate the effect of using the Multi-Sensory Approach for teaching students with learning disabilities on the sixth grade students' achievement in mathematics at Jordanian public schools. To achieve the purpose of the study, a pre/post-test was constructed to measure students' achievement in mathematics. The…

Construction Occupations--Finishing. Reprinted from the Occupational Outlook Handbook, 1978-79 Edition.

ERIC Educational Resources Information Center

Bureau of Labor Statistics (DOL), Washington, DC.

Focusing on finishing construction occupations, this document is one in a series of forty-one reprints from the Occupational Outlook Handbook providing current information and employment projections for individual occupations and industries through 1985. The specific occupations covered in this document include air…

Introduction to Carpentry. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide on the specialty area of carpentry is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in…

Introduction to Bricklaying. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide on the specialty area of bricklaying is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in…

Development of Commercial Thermo-sensitive Genic Male Sterile Rice Accelerates Hybrid Rice Breeding Using the CRISPR/Cas9-mediated TMS5 Editing System.

PubMed

Zhou, Hai; He, Ming; Li, Jing; Chen, Liang; Huang, Zhifeng; Zheng, Shaoyan; Zhu, Liya; Ni, Erdong; Jiang, Dagang; Zhao, Bingran; Zhuang, Chuxiong

2016-11-22

Hybrid rice breeding offers an important strategy to improve rice production, in which the cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 systems have been widely used in target-site genome editing, whereas their application for crop genetic improvement has been rarely reported. Here, using the CRISPR/Cas9 system, we induced specific mutations in TMS5, which is the most widely applied thermo-sensitive genic male sterility (TGMS) gene in China, and developed new "transgene clean" TGMS lines. We designed 10 target sites in the coding region of TMS5 for targeted mutagenesis using the CRISPR/Cas9 system and assessed the potential rates of on- and off-target effects. Finally, we established the most efficient construct, the TMS5ab construct, for breeding potentially applicable "transgene clean" TGMS lines. We also discussed factors that affect the editing efficiency according to the characteristics of different target sequences. Notably, using the TMS5ab construct, we developed 11 new "transgene clean" TGMS lines with potential applications in hybrid breeding within only one year in both rice subspecies. The application of our system not only significantly accelerates the breeding of sterile lines but also facilitates the exploitation of heterosis.

Introduction to Drywall. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide on the specialty area of drywall is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in mind.…

Using Wikis to Develop Collaborative Communities in an Environmental Chemistry Course

ERIC Educational Resources Information Center

Pence, Laura E.; Pence, Harry E.

2015-01-01

Group construction of wikis in an environmental chemistry course provided an effective framework for students to develop and to manage collaborative communities, characterized by interactive projects designed to deepen learning. A sequence of assignments facilitated improvement of the students' wiki construction and editing skills and these…

Introduction to Bricklaying. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in bricklaying to students who have chosen to explore careers in construction. The following topics are covered in the course's three instructional units: bricklaying materials, bricklaying tools, and applied skills. Each unit contains some or…

Introduction to Concrete Masonry. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide on the specialty area of concrete masonry is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs…

Introduction to Plumbing. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide on the specialty area of plumbing is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in mind.…

Introduction to Sheet Metal. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This competency-based curriculum guide on the specialty area of sheet metal is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in…

Design and assessment of engineered CRISPR-Cpf1 and its use for genome editing.

PubMed

Li, Bin; Zeng, Chunxi; Dong, Yizhou

2018-05-01

Cpf1, a CRISPR endonuclease discovered in Prevotella and Francisella 1 bacteria, offers an alternative platform for CRISPR-based genome editing beyond the commonly used CRISPR-Cas9 system originally discovered in Streptococcus pyogenes. This protocol enables the design of engineered CRISPR-Cpf1 components, both CRISPR RNAs (crRNAs) to guide the endonuclease and Cpf1 mRNAs to express the endonuclease protein, and provides experimental procedures for effective genome editing using this system. We also describe quantification of genome-editing activity and off-target effects of the engineered CRISPR-Cpf1 in human cell lines using both T7 endonuclease I (T7E1) assay and targeted deep sequencing. This protocol enables rapid construction and identification of engineered crRNAs and Cpf1 mRNAs to enhance genome-editing efficiency using the CRISPR-Cpf1 system, as well as assessment of target specificity within 2 months. This protocol may also be appropriate for fine-tuning other types of CRISPR systems.

Multiplexed precision genome editing with trackable genomic barcodes in yeast.

PubMed

Roy, Kevin R; Smith, Justin D; Vonesch, Sibylle C; Lin, Gen; Tu, Chelsea Szu; Lederer, Alex R; Chu, Angela; Suresh, Sundari; Nguyen, Michelle; Horecka, Joe; Tripathi, Ashutosh; Burnett, Wallace T; Morgan, Maddison A; Schulz, Julia; Orsley, Kevin M; Wei, Wu; Aiyar, Raeka S; Davis, Ronald W; Bankaitis, Vytas A; Haber, James E; Salit, Marc L; St Onge, Robert P; Steinmetz, Lars M

2018-07-01

Our understanding of how genotype controls phenotype is limited by the scale at which we can precisely alter the genome and assess the phenotypic consequences of each perturbation. Here we describe a CRISPR-Cas9-based method for multiplexed accurate genome editing with short, trackable, integrated cellular barcodes (MAGESTIC) in Saccharomyces cerevisiae. MAGESTIC uses array-synthesized guide-donor oligos for plasmid-based high-throughput editing and features genomic barcode integration to prevent plasmid barcode loss and to enable robust phenotyping. We demonstrate that editing efficiency can be increased more than fivefold by recruiting donor DNA to the site of breaks using the LexA-Fkh1p fusion protein. We performed saturation editing of the essential gene SEC14 and identified amino acids critical for chemical inhibition of lipid signaling. We also constructed thousands of natural genetic variants, characterized guide mismatch tolerance at the genome scale, and ascertained that cryptic Pol III termination elements substantially reduce guide efficacy. MAGESTIC will be broadly useful to uncover the genetic basis of phenotypes in yeast.

What Does the Cognitive Assessment System (CAS) Measure? Joint Confirmatory Factor Analysis of the CAS and the Woodcock-Johnson Tests of Cognitive Ability (3rd Edition).

ERIC Educational Resources Information Center

Keith, Timothy Z.; Kranzler, John H.; Flanagan, Dawn P.

2001-01-01

Reports the results of the first joint confirmatory factor analysis (CFA) of the Cognitive Assessment System (CAS) and the Woodcock-Johnson Tests of Cognitive Abilities-3rd Edition (WJ III). Results of these analyses do not support the construct validity of the CAS as a measure of the PASS (planning, attention, simultaneous, and sequential)…

Design Experiments in Japanese Elementary Science Education with Computer Support for Collaborative Learning: Hypothesis Testing and Collaborative Construction

ERIC Educational Resources Information Center

Oshima, Jun; Oshima, Ritsuko; Murayama, Isao; Inagaki, Shigenori; Takenaka, Makiko; Nakayama, Hayashi; Yamaguchi, Etsuji

2004-01-01

This paper reports design experiments on two Japanese elementary science lesson units in a sixth-grade classroom supported by computer support for collaborative learning (CSCL) technology as a collaborative reflection tool. We took different approaches in the experiments depending on their instructional goals. In the unit 'air and how things…

Josh's Operational Conjectures: Abductions of a Splitting Operation and the Construction of New Fractional Schemes

ERIC Educational Resources Information Center

Norton, Anderson

2008-01-01

This article reports on students' learning through conjecturing, by drawing on a semester-long teaching experiment with 6 sixth-grade students. It focuses on 1 of the students, Josh, who developed especially powerful ways of operating over the course of the teaching experiment. Through a fine-grained analysis of Josh's actions, this article…

Visual Thinking in Teaching History: Reading the Visual Thinking Skills of 12 Year-Old Pupils in Istanbul

ERIC Educational Resources Information Center

Dilek, Gulcin

2010-01-01

This study aims to explore the visual thinking skills of some sixth grade (12-13 year-old) primary pupils who created visual interpretations during history courses. Pupils drew pictures describing historical scenes or events based on visual sources. They constructed these illustrations by using visual and written primary and secondary sources in…

The Museum Connection, Grade Six: Early Harmonist Life and Construction Techniques. Unit V, Draft #2.

ERIC Educational Resources Information Center

Chastain, Marsha; Glendenning, Owen

This third project of "The Museum Connection" is designed for sixth grade students and is devoted to New Harmony, Indiana's first utopian community (1814-24). Eight lesson plans include information on materials needed and activities. Goals include: (1) to compare and contrast modern-day New Harmony to Harmonie, Indiana in 1816; (2) to…

Does Socio-Economic Status Moderate the Associations between Psychosocial Predictors and Fruit Intake in Schoolchildren? The Pro Children Study

ERIC Educational Resources Information Center

Sandvik, C.; Gjestad, R.; Samdal, O.; Brug, J.; Klepp, K. -I.

2010-01-01

This study tested whether socio-economic status (SES) moderated the association between the psychosocial constructs included in the attitude-social influence-self-efficacy (ASE) model and fruit intake in Norwegian schoolchildren. The sample consisted of 962 Norwegian sixth graders, mean age 11.3 years. They were split into three SES groups, and…

Construction of an evidence-based, graduated training curriculum for D-box, a webcam-based laparoscopic basic skills trainer box.

PubMed

Debes, Anders J; Aggarwal, Rajesh; Balasundaram, Indran; Jacobsen, Morten B J

2012-06-01

Surgical training programs are now including simulators as training tools for teaching laparoscopic surgery. The aim of this study was to develop a standardized, graduated, and evidence-based curriculum for the newly developed D-box (D-box Medical, Lier, Norway) for training basic laparoscopic skills. Eighteen interns with no laparoscopic experience completed a training program on the D-box consisting of 8 sessions of 5 tasks with assessment on a sixth task. Performance was measured by the use of 3-dimensional electromagnetic tracking of hand movements, path length, and time taken. Ten experienced surgeons (>100 laparoscopic surgeries, median 250) were recruited for establishing benchmark criteria. Significant learning curves were obtained for all construct valid parameters for tasks 4 (P < .005) and 5 (P < .005) and reached plateau levels between the fifth and sixth session. Within the 8 sessions of this study, between 50% and 89% of the interns reached benchmark criteria on tasks 4 and 5. Benchmark criteria and an evidence-based curriculum have been developed for the D-box. The curriculum is aimed at training and assessing surgical novices in basic laparoscopic skills. Copyright © 2012 Elsevier Inc. All rights reserved.

Construction of an easy-to-use CRISPR-Cas9 system by patching a newly designed EXIT circuit.

PubMed

Tang, Qiang; Lou, Chunbo; Liu, Shuang-Jiang

2017-01-01

Plasmid-borne genetic editing tools, including the widely used CRISPR-Cas9 system, have greatly facilitated bacterial programming to obtain novel functionalities. However, the lack of effective post-editing plasmid elimination methods impedes follow-up genetic manipulation or application. Conventional strategies including exposure to physical and chemical treatments, or exploiting temperature-sensitive replication origins have several drawbacks (e.g., they are limited for efficiency and are time-consuming). Therefore, the demand is apparent for easy and rapid elimination of the tool plasmids from their bacterial hosts after genetic manipulation. To bridge this gap, we designed a novel EXIT circuit with the homing endonuclease, which can be exploited for rapid and efficient elimination of various plasmids with diverse replication origins. As a proof of concept, we validated the EXIT circuit in Escherichia coli by harnessing homing endonuclease I- Sce I and its cleavage site. When integrated into multiple plasmids with different origins, the EXIT circuit allowed them to be eliminated from the host cells, simultaneously. By combining the widely used plasmid-borne CRISPR-Cas9 system and the EXIT circuit, we constructed an easy-to-use CRISPR-Cas9 system that eliminated the Cas9- and the single-guide RNA (sgRNA)-encoding plasmids in one-step. Within 3 days, we successfully constructed an atrazine-degrading E. coli strain, thus further demonstrating the advantage of this new CRISPR-Cas9 system for bacterial genome editing. Our novel EXIT circuit, which exploits the homing endonuclease I- Sce I, enables plasmid(s) with different replication origins to be eliminated from their host cells rapidly and efficiently. We also developed an easy-to-use CRISPR-Cas9 system with the EXIT circuit, and this new system can be widely applied to bacterial genome editing.

Beyond refractory obsessions and anxiety states: toward remission.

PubMed

Hollander, Eric; Zohar, Joseph

2004-01-01

At the Sixth International Obsessive-Compulsive Disorder Conference (IOCDC), held November 13-15, 2003, in Lanzarote, Spain, 2 issues were discussed that are of great importance to future research on obsessive-compulsive disorder (OCD). The first of these is the possible inclusion of obsessive-compulsive spectrum disorders (OCSD) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. OCSD resemble OCD in their clinical symptoms, associated features, comorbidity, family/genetics, etiology, and neurocircuitry, as well as their selective response to treatment with serotonin reuptake inhibitors. The second issue is considering remission as the ultimate goal of treatment for OCD instead of just symptom reduction, as has been suggested in other disorders. These and other issues should be discussed at future meetings of the IOCDC and influence how we conceptualize the disorder and design future treatment trials.

CRISPR/Cas9-Based Multiplex Genome Editing in Monocot and Dicot Plants.

PubMed

Ma, Xingliang; Liu, Yao-Guang

2016-07-01

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome targeting system has been applied to a variety of organisms, including plants. Compared to other genome-targeting technologies such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), the CRISPR/Cas9 system is easier to use and has much higher editing efficiency. In addition, multiple "single guide RNAs" (sgRNAs) with different target sequences can be designed to direct the Cas9 protein to multiple genomic sites for simultaneous multiplex editing. Here, we present a procedure for highly efficient multiplex genome targeting in monocot and dicot plants using a versatile and robust CRISPR/Cas9 vector system, emphasizing the construction of binary constructs with multiple sgRNA expression cassettes in one round of cloning using Golden Gate ligation. We also describe the genotyping of targeted mutations in transgenic plants by direct Sanger sequencing followed by decoding of superimposed sequencing chromatograms containing biallelic or heterozygous mutations using the Web-based tool DSDecode. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Evaluation of Sixth Edition of AJCC Staging System for Nasopharyngeal Carcinoma and Proposed Improvement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Mengzhong; Tang Linglong; Zong Jingfeng

2008-03-15

Purpose: To evaluate the 6th edition of the International Union Against Cancer/American Joint Committee on Cancer staging system for nasopharyngeal carcinoma and to search for ways to improve the system. Methods and Materials: We performed a retrospective review of data from 749 biopsy-proven nonmetastatic nasopharyngeal carcinoma patients. All patients had undergone contrast-enhanced computed tomography and had received radiotherapy as their primary treatment. Results: The T stage, N stage, and stage group were significant, independent predictors for disease-specific death. No significant differences were found between Stage T2a and T1 in local failure-free survival or between Stage N3a and N2 in distantmore » failure-free survival. Survival curves of the different T/N subsets showed a better segregation when T2a and N3a were downstaged to T1 and N2, respectively. The hazard ratio of disease-specific deaths for patients with T2N0 disease was similar to that of patients with T1N0 disease; the same result was found for the T3N0 and T4N0 subsets. Downstaging the T2N0 subset to Stage I, T3N0 to Stage II, and T4N0 to Stage III resulted in a more balanced patient distribution, better hazard consistency among subgroups, and improved hazard discrimination between overall stages. Conclusion: Using the 6th edition of the American Joint Committee on Cancer staging system produced an acceptable distribution of patient numbers and segregation of survival curves among the different stage groups. The prognostic accuracy of the staging system could be improved by recategorization of the T, N, and group stage criteria.« less

Building a List of Journals with Constructed Impact Factors.

ERIC Educational Resources Information Center

Stegmann, Johannes

1999-01-01

Describes the building of a list of constructed-impact factors (CIF) for biomedical journals not included in the 1996 editions of the "Journal Citation Reports." The online retrieval from the host DIMDI of the data needed for impact-factor calculation is described. The top 100 (of 338 titles, ranked according to their CIFs) are…

Introduction to Drywall. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in drywalling to students who have chosen to explore careers in construction. It contains three units: drywall materials, drywall tools, and applied skills. Each instructional unit includes some or all of the basic components of a unit of…

Construct and Concurrent Validity of a Prototype Questionnaire to Survey Public Attitudes toward Stuttering

ERIC Educational Resources Information Center

St. Louis, Kenneth O.; Reichel, Isabella K.; Yaruss, J. Scott; Lubker, Bobbie Boyd

2009-01-01

Purpose: Construct validity and concurrent validity were investigated in a prototype survey instrument, the "Public Opinion Survey of Human Attributes-Experimental Edition" (POSHA-E). The POSHA-E was designed to measure public attitudes toward stuttering within the context of eight other attributes, or "anchors," assumed to range from negative…

Introduction to Insulation. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in insulation to students who have chosen to explore careers in construction. It contains three units: instructional unit includes some or all of the basic components of a unit of instruction: performance objectives, suggested activities for the…

Introduction to Concrete Finishing. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in concrete finishing to students who have chosen to explore careers in construction. The following topics are covered in the course's three instructional units: concrete materials, concrete tools, and applied skills. Each unit contains some or…

Introduction to Carpentry. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in carpentry to students who have chosen to explore careers in construction. The following topics are covered in the course's three instructional units: carpentry materials, carpentry tools, and applied skills. Each unit contains some or all of…

Introduction to Sheet Metal. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in sheet metal work to students who have chosen to explore careers in construction. The following topics are covered in the course's three instructional units: sheet metal materials, sheet metal tools, and applied skills. Each unit contains some…

Residential Construction. Technology Learning Activity. Teacher Edition. Technology Education Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This packet of technology learning activity (TLA) materials for residential construction for students in grades 6-10 consists of an instructor's section and student materials. The instructor's section contains background information, suggested activities, and a list of suggested resources. A lesson plan for the 10-day module includes assignments;…

Editing wild points in isolation - Fast agreement for reliable systems (Preliminary version)

NASA Technical Reports Server (NTRS)

Kearns, Phil; Evans, Carol

1989-01-01

Consideration is given to the intuitively appealing notion of discarding sensor values which are strongly suspected of being erroneous in a modified approximate agreement protocol. Approximate agreement with editing imposes a time bound upon the convergence of the protocol - no such bound was possible for the original approximate agreement protocol. This new approach is potentially useful in the construction of asynchronous fault tolerant systems. The main result is that a wild-point replacement technique called t-worst editing can be shown to guarantee convergence of the approximate agreement protocol to a valid agreement value. Results are presented for a four-processor synchronous system in which a single processor may be faulty.

High-Efficiency Genome Editing of Streptomyces Species by an Engineered CRISPR/Cas System.

PubMed

Wang, Y; Cobb, R E; Zhao, H

2016-01-01

Next-generation sequencing technologies have rapidly expanded the genomic information of numerous organisms and revealed a rich reservoir of natural product gene clusters from microbial genomes, especially from Streptomyces, the largest genus of known actinobacteria at present. However, genetic engineering of these bacteria is often time consuming and labor intensive, if even possible. In this chapter, we describe the design and construction of pCRISPomyces, an engineered Type II CRISPR/Cas system, for targeted multiplex gene deletions in Streptomyces lividans, Streptomyces albus, and Streptomyces viridochromogenes with editing efficiency ranging from 70% to 100%. We demonstrate pCRISPomyces as a powerful tool for genome editing in Streptomyces. © 2016 Elsevier Inc. All rights reserved.

Airfield construction (3rd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Goretskii, Leonid I.; Boguslavskii, Adol'f. M.; Serebrenikov, Vadim A.; Barzdo, V. I.; Leshchitskaia, T. P.; Polosin-Nikitin, S. M.

The principal engineering aspects of airfield construction are discussed. In particular, attention is given to the fundamental principles and organizational aspects of airfield construction; excavation work and airfield layout; construction of drainage systems; foundations and pavements; and quality control and safety engineering. The discussion also covers the operation of various support plants, including concrete production and mixing, production of asphalt-concrete mixtures and organic binders, production of structural steel and reinforced concrete components, and operation of stone quarries and gravel pits.

Development of a genome editing technique using the CRISPR/Cas9 system in the industrial filamentous fungus Aspergillus oryzae.

PubMed

Katayama, Takuya; Tanaka, Yuki; Okabe, Tomoya; Nakamura, Hidetoshi; Fujii, Wataru; Kitamoto, Katsuhiko; Maruyama, Jun-Ichi

2016-04-01

To develop a genome editing method using the CRISPR/Cas9 system in Aspergillus oryzae, the industrial filamentous fungus used in Japanese traditional fermentation and for the production of enzymes and heterologous proteins. To develop the CRISPR/Cas9 system as a genome editing technique for A. oryzae, we constructed plasmids expressing the gene encoding Cas9 nuclease and single guide RNAs for the mutagenesis of target genes. We introduced these into an A. oryzae strain and obtained transformants containing mutations within each target gene that exhibited expected phenotypes. The mutational rates ranged from 10 to 20 %, and 1 bp deletions or insertions were the most commonly induced mutations. We developed a functional and versatile genome editing method using the CRISPR/Cas9 system in A. oryzae. This technique will contribute to the use of efficient targeted mutagenesis in many A. oryzae industrial strains.

Development of Commercial Thermo-sensitive Genic Male Sterile Rice Accelerates Hybrid Rice Breeding Using the CRISPR/Cas9-mediated TMS5 Editing System

PubMed Central

Zhou, Hai; He, Ming; Li, Jing; Chen, Liang; Huang, Zhifeng; Zheng, Shaoyan; Zhu, Liya; Ni, Erdong; Jiang, Dagang; Zhao, Bingran; Zhuang, Chuxiong

2016-01-01

Hybrid rice breeding offers an important strategy to improve rice production, in which the cultivation of a male sterile line is the key to the success of cross-breeding. CRISPR/Cas9 systems have been widely used in target-site genome editing, whereas their application for crop genetic improvement has been rarely reported. Here, using the CRISPR/Cas9 system, we induced specific mutations in TMS5, which is the most widely applied thermo-sensitive genic male sterility (TGMS) gene in China, and developed new “transgene clean” TGMS lines. We designed 10 target sites in the coding region of TMS5 for targeted mutagenesis using the CRISPR/Cas9 system and assessed the potential rates of on- and off-target effects. Finally, we established the most efficient construct, the TMS5ab construct, for breeding potentially applicable “transgene clean” TGMS lines. We also discussed factors that affect the editing efficiency according to the characteristics of different target sequences. Notably, using the TMS5ab construct, we developed 11 new “transgene clean” TGMS lines with potential applications in hybrid breeding within only one year in both rice subspecies. The application of our system not only significantly accelerates the breeding of sterile lines but also facilitates the exploitation of heterosis. PMID:27874087

"Are You Gonna Show This to White People?": Chicana/o and Latina/o Students' Counter-Narratives on Race, Place, and Representation

ERIC Educational Resources Information Center

Martínez, Ramón Antonio

2017-01-01

This article explores the recurring narratives on race, place and representation that emerged in the talk of Chicana/o and Latina/o sixth-graders at a middle school in East Los Angeles, California. Discourse analytic methods are used to closely examine how these narratives were constructed within the contexts of everyday classroom interactions.…

Sixth Graders' Co-Construction of Explanations of a Disturbance in an Ecosystem: Exploring Relationships between Grouping, Reflective Scaffolding, and Evidence-Based Explanations

ERIC Educational Resources Information Center

Kyza, Eleni A.; Constantinou, Costas P.; Spanoudis, George

2011-01-01

We report on a study investigating the relationship between cognitive ability grouping, reflective inquiry scaffolding, and students' collaborative explanations of an ecosystem disturbance which took place when a number of flamingo birds died in a salt lake because of nearby intensive human activities. Twenty-six pairs of students from two intact…

Construct Validity of the WISC-IV with a Referred Sample: Direct versus Indirect Hierarchical Structures

ERIC Educational Resources Information Center

Canivez, Gary L.

2014-01-01

The Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) is one of the most frequently used intelligence tests in clinical assessments of children with learning difficulties. Construct validity studies of the WISC-IV have generally supported the higher order structure with four correlated first-order factors and one higher-order…

Correct Interpretation of Latent Versus Observed Abilities: "Implications From Structural Equation Modeling Applied to the WISC-III and WIAT Linking Sample"

ERIC Educational Resources Information Center

Oh, Hyeon-Joo; Glutting, Joseph J.; Watkins, Marley W.; Youngstrom, Eric A.; McDermott, Paul A.

2004-01-01

In this study, the authors used structural equation modeling to investigate relationships between ability constructs from the "Wechsler Intelligence Scale for Children-Third Edition" (WISC-III; Wechsler, 1991) in explaining reading and mathematics achievement constructs on the "Wechsler Individual Achievement Test" (WIAT;…

Introduction to Heating, Ventilation and Air Conditioning (HVAC). Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This instructor's guide contains the materials required to teach a competency-based introductory course in heating, ventilating, and air conditioning (HVAC) to students who have chosen to explore careers in construction. It contains three units: HVAC materials, HVAC tools, and applied skills. Each instructional unit includes some or all of the…

"You Don't Look Like Your Profile Picture": The Ethical Implications of Researching Online Identities in Higher Education

ERIC Educational Resources Information Center

Blanco Ramírez, Gerardo; Palu-ay, Lyssa

2015-01-01

Social media sites and other contemporary technologies open the possibility for the construction of online identities that are loosely connected to physical bodies; this construction allows individuals to edit their identities constantly, in a continuous process of self-recreation. In parallel, universities utilise printed and electronic media to…

Efficient genome editing of differentiated renal epithelial cells.

PubMed

Hofherr, Alexis; Busch, Tilman; Huber, Nora; Nold, Andreas; Bohn, Albert; Viau, Amandine; Bienaimé, Frank; Kuehn, E Wolfgang; Arnold, Sebastian J; Köttgen, Michael

2017-02-01

Recent advances in genome editing technologies have enabled the rapid and precise manipulation of genomes, including the targeted introduction, alteration, and removal of genomic sequences. However, respective methods have been described mainly in non-differentiated or haploid cell types. Genome editing of well-differentiated renal epithelial cells has been hampered by a range of technological issues, including optimal design, efficient expression of multiple genome editing constructs, attainable mutation rates, and best screening strategies. Here, we present an easily implementable workflow for the rapid generation of targeted heterozygous and homozygous genomic sequence alterations in renal cells using transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeat (CRISPR) system. We demonstrate the versatility of established protocols by generating novel cellular models for studying autosomal dominant polycystic kidney disease (ADPKD). Furthermore, we show that cell culture-validated genetic modifications can be readily applied to mouse embryonic stem cells (mESCs) for the generation of corresponding mouse models. The described procedure for efficient genome editing can be applied to any cell type to study physiological and pathophysiological functions in the context of precisely engineered genotypes.

A comprehensive overview of computational resources to aid in precision genome editing with engineered nucleases.

PubMed

Periwal, Vinita

2017-07-01

Genome editing with engineered nucleases (zinc finger nucleases, TAL effector nucleases s and Clustered regularly inter-spaced short palindromic repeats/CRISPR-associated) has recently been shown to have great promise in a variety of therapeutic and biotechnological applications. However, their exploitation in genetic analysis and clinical settings largely depends on their specificity for the intended genomic target. Large and complex genomes often contain highly homologous/repetitive sequences, which limits the specificity of genome editing tools and could result in off-target activity. Over the past few years, various computational approaches have been developed to assist the design process and predict/reduce the off-target activity of these nucleases. These tools could be efficiently used to guide the design of constructs for engineered nucleases and evaluate results after genome editing. This review provides a comprehensive overview of various databases, tools, web servers and resources for genome editing and compares their features and functionalities. Additionally, it also describes tools that have been developed to analyse post-genome editing results. The article also discusses important design parameters that could be considered while designing these nucleases. This review is intended to be a quick reference guide for experimentalists as well as computational biologists working in the field of genome editing with engineered nucleases. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Virginia Henderson and her timeless writings.

PubMed

Halloran, E J

1996-01-01

This paper provides a reflection on the written works of Miss Virginia Avenel Henderson. Miss Henderson is a nurse, a scientist, an artist and a quintessential human being--all traits which informed her written output. Nursing practice, research and education were all subjects of her extensive chronicle. The four-volume Nursing Studies Index is her contribution to nursing research. The Index was sandwiched between two revisions of Principles and Practice of Nursing (5th and 6th eds), the placement of which caused the Index to focus on practice and the Principles (6th ed.) to be based on research. The sixth edition of Principles, written with Gladys Nite and 17 contributors, is considered the most important single professional document written in the twentieth century. The book synthesizes nursing practice, education, theory and research in an age when many nurses are challenged by the seeming incongruity in these essential professional functions.

Balance outcomes following a tap dance program for a child with congenital myotonic muscular dystrophy.

PubMed

Biricocchi, Charlanne; Drake, JaimeLynn; Svien, Lana

2014-01-01

This case report describes the effects of a 6-week progressive tap dance program on static and dynamic balance for a child with type 1 congenital myotonic muscular dystrophy (congenital MMD1). A 6-year-old girl with congenital MMD1 participated in a 1-hour progressive tap dance program. Classes were held once a week for 6 consecutive weeks and included 3 children with adaptive needs and 1 peer with typical development. The Bruininks-Oseretsky Test of Motor Proficiency, second edition (BOT-2) balance subsection and the Pediatric Balance Scale were completed at the beginning of the first class and the sixth class. The participant's BOT-2 score improved from 3 to 14. Her Pediatric Balance Scale score did not change. Participation in a progressive tap dance class by a child with congenital MMD1 may facilitate improvements in static and dynamic balance.

The art and science of patient storytelling-harnessing narrative communication for behavioral interventions: the ACCE project.

PubMed

Houston, Thomas K; Cherrington, Andrea; Coley, Heather L; Robinson, Kimberly M; Trobaugh, John A; Williams, Jessica H; Foster, Pamela H; Ford, Daniel E; Gerber, Ben S; Shewchuk, Richard M; Allison, Jeroan J

2011-08-01

Narrative communication is an emerging form of persuasive communication used in health education to solicit actual patient stories. Eliciting a narrative is an open-ended process and may or may not map to desired intervention objectives or underlying behavioral constructs. In addition, incorporating actual, unscripted narratives into multimedia interventions is challenging. The authors evaluated a protocol of editing narratives for a multimedia intervention to promote smoking cessation in the African American community that maintains fidelity to the original message and was related to behavioral constructs from social cognitive theory. The authors used four steps: (a) narrative collection (videotaping), (b) narrative review (rating of content), (c) narrative editing (documentary style), and (d) pilot testing (usability and assessment of transportation). The authors videotaped 50 personal smoking cessation narratives. After coding for presence of theoretical constructs, perceived risks of smoking (present in 53% of narratives) was the most common related behavioral construct. Four narratives were chosen for inclusion in the DVD. Pilot testing showed viewers reported high level of transportation into the narrative. The authors found that some behavioral constructs were rare and difficult to solicit in this population but that the final product was engaging to the viewers. Lessons learned may be useful for other video-based behavioral interventions that incorporate personal narratives.

The Reconstruction of the Past through Images: An Iconographic Analysis on the Historical Imagination Usage Skills of Primary School Pupils

ERIC Educational Resources Information Center

Dilek, Dursun

2009-01-01

The aim of this research is to understand how sixth grade students use their imagination skills in the historical thinking process and, by doing so, how they construct the past. In this respect, first, an exhibition/museum was visited in the context of social studies during history lessons in a primary school in Kadikoy district in Istanbul. Then,…

Ambiguities in the definition of quasilocal mass

NASA Technical Reports Server (NTRS)

Woodhouse, N. M. J.

1987-01-01

For a small surface in a vacuum spacetime, some components of the kinematic twistor are nonzero at the fifth order in the diameter of the surface even though, according to Penrose's (1986) modified construction, the leading term in the quasi-local mass m(p) is sixth order (or higher). This implies that the leading term in m(p) cannot be defined independently of higher-order terms in the twistor norm.

A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation.

PubMed

Lowder, Levi G; Zhang, Dengwei; Baltes, Nicholas J; Paul, Joseph W; Tang, Xu; Zheng, Xuelian; Voytas, Daniel F; Hsieh, Tzung-Fu; Zhang, Yong; Qi, Yiping

2015-10-01

The relative ease, speed, and biological scope of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated Protein9 (Cas9)-based reagents for genomic manipulations are revolutionizing virtually all areas of molecular biosciences, including functional genomics, genetics, applied biomedical research, and agricultural biotechnology. In plant systems, however, a number of hurdles currently exist that limit this technology from reaching its full potential. For example, significant plant molecular biology expertise and effort is still required to generate functional expression constructs that allow simultaneous editing, and especially transcriptional regulation, of multiple different genomic loci or multiplexing, which is a significant advantage of CRISPR/Cas9 versus other genome-editing systems. To streamline and facilitate rapid and wide-scale use of CRISPR/Cas9-based technologies for plant research, we developed and implemented a comprehensive molecular toolbox for multifaceted CRISPR/Cas9 applications in plants. This toolbox provides researchers with a protocol and reagents to quickly and efficiently assemble functional CRISPR/Cas9 transfer DNA constructs for monocots and dicots using Golden Gate and Gateway cloning methods. It comes with a full suite of capabilities, including multiplexed gene editing and transcriptional activation or repression of plant endogenous genes. We report the functionality and effectiveness of this toolbox in model plants such as tobacco (Nicotiana benthamiana), Arabidopsis (Arabidopsis thaliana), and rice (Oryza sativa), demonstrating its utility for basic and applied plant research. © 2015 American Society of Plant Biologists. All Rights Reserved.

Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, paranoid personality disorder diagnosis: a unitary or a two-dimensional construct?

PubMed

Falkum, Erik; Pedersen, Geir; Karterud, Sigmund

2009-01-01

This article examines reliability and validity aspects of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) paranoid personality disorder (PPD) diagnosis. Patients with personality disorders (n = 930) from the Norwegian network of psychotherapeutic day hospitals, of which 114 had PPD, were included in the study. Frequency distribution, chi(2), correlations, reliability statistics, exploratory, and confirmatory factor analyses were performed. The distribution of PPD criteria revealed no distinct boundary between patients with and without PPD. Diagnostic category membership was obtained in 37 of 64 theoretically possible ways. The PPD criteria formed a separate factor in a principal component analysis, whereas a confirmatory factor analysis indicated that the DSM-IV PPD construct consists of 2 separate dimensions as follows: suspiciousness and hostility. The reliability of the unitary PPD scale was only 0.70, probably partly due to the apparent 2-dimensionality of the construct. Persistent unwarranted doubts about the loyalty of friends had the highest diagnostic efficiency, whereas unwarranted accusations of infidelity of partner had particularly poor indicator properties. The reliability and validity of the unitary PPD construct may be questioned. The 2-dimensional PPD model should be further explored.

Sixth Warren K. Sinclair keynote address: The role of a strong regulator in safe and secure nuclear energy.

PubMed

Lyons, Peter B

2011-01-01

The history of nuclear regulation is briefly reviewed to underscore the early recognition that independence of the regulator was essential in achieving and maintaining public credibility. The current licensing process is reviewed along with the status of applications. Challenges faced by both the NRC and the industry are reviewed, such as new construction techniques involving modular construction, digital controls replacing analog circuitry, globalization of the entire supply chain, and increased security requirements. The vital area of safety culture is discussed in some detail, and its importance is emphasized. Copyright © 2010 Health Physics Society

Variability of cement-treated layers in MDOT road projects.

DOT National Transportation Integrated Search

2011-12-01

The Mississippi Department of Transportation revised the specifications for cement-treated : bases between the 1990 and 2004 editions of Mississippi Standard Specifications for Road and Bridge : Construction. The required compressive strength o...

Updating OSHA Standards Based on National Consensus Standards; Eye and Face Protection. Final rule.

PubMed

2016-03-25

On March 13, 2015, OSHA published in the Federal Register a notice of proposed rulemaking (NPRM) to revise its eye and face protection standards for general industry, shipyard employment, marine terminals, longshoring, and construction by updating the references to national consensus standards approved by the American National Standards Institute (ANSI). OSHA received no significant objections from commenters and therefore is adopting the amendments as proposed. This final rule updates the references in OSHA's eye and face standards to reflect the most recent edition of the ANSI/International Safety Equipment Association (ISEA) eye and face protection standard. It removes the oldest-referenced edition of the same ANSI standard. It also amends other provisions of the construction eye and face protection standard to bring them into alignment with OSHA's general industry and maritime standards.

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.

PubMed

Yumlu, Saniye; Stumm, Jürgen; Bashir, Sanum; Dreyer, Anne-Kathrin; Lisowski, Pawel; Danner, Eric; Kühn, Ralf

2017-05-15

Human induced pluripotent stem cells (hiPSCs) represent an ideal in vitro platform to study human genetics and biology. The recent advent of programmable nucleases makes also the human genome amenable to experimental genetics through either the correction of mutations in patient-derived iPSC lines or the de novo introduction of mutations into otherwise healthy iPSCs. The production of specific and sometimes complex genotypes in multiple cell lines requires efficient and streamlined gene editing technologies. In this article we provide protocols for gene editing in hiPSCs. We presently achieve high rates of gene editing at up to three loci using a modified iCRISPR system. This system includes a doxycycline inducible Cas9 and sgRNA/reporter plasmids for the enrichment of transfected cells by fluorescence-activated cell sorting (FACS). Here we cover the selection of target sites, vector construction, transfection, and isolation and genotyping of modified hiPSC clones. Copyright © 2017 Elsevier Inc. All rights reserved.

CRISPR-Cas9 vectors for genome editing and host engineering in the baculovirus-insect cell system.

PubMed

Mabashi-Asazuma, Hideaki; Jarvis, Donald L

2017-08-22

The baculovirus-insect cell system (BICS) has been widely used to produce many different recombinant proteins for basic research and is being used to produce several biologics approved for use in human or veterinary medicine. Early BICS were technically complex and constrained by the relatively primordial nature of insect cell protein glycosylation pathways. Since then, recombination has been used to modify baculovirus vectors-which has simplified the system-and transform insect cells, which has enhanced its protein glycosylation capabilities. Now, CRISPR-Cas9 tools for site-specific genome editing are needed to facilitate further improvements in the BICS. Thus, in this study, we used various insect U6 promoters to construct CRISPR-Cas9 vectors and assessed their utility for site-specific genome editing in two insect cell lines commonly used as hosts in the BICS. We demonstrate the use of CRISPR-Cas9 to edit an endogenous insect cell gene and alter protein glycosylation in the BICS.

A Taxometric Investigation of "DSM-IV" Major Depression in a Large Outpatient Sample: Interpretable Structural Results Depend on the Mode of Assessment

ERIC Educational Resources Information Center

Ruscio, John; Brown, Timothy A.; Ruscio, Ayelet Meron

2009-01-01

Most taxometric studies of depressive constructs have drawn indicators from self-report instruments that do not bear directly on the "Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV)" diagnostic construct of major depressive disorder (MDD). The present study examined the latent structure of MDD using indicator sets…

An introduction to niche construction theory.

PubMed

Laland, Kevin; Matthews, Blake; Feldman, Marcus W

Niche construction refers to the modification of selective environments by organisms. Theoretical and empirical studies of niche construction are increasing in importance as foci in evolutionary ecology. This special edition presents theoretical and empirical research that illustrates the significance of niche construction to the field. Here we set the scene for the following papers by (1) discussing the history of niche construction research, (2) providing clear definitions that distinguish niche construction from related concepts such as ecosystem engineering and the extended phenotype, (3) providing a brief summary of the findings of niche construction research, (4) discussing the contribution of niche construction and ecological inheritance to (a) expanded notions of inheritance, and (b) the extended evolutionary synthesis, and (5) briefly touching on some of the issues that underlie the controversies over niche construction.

Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules.

PubMed

Gozu, Hulya; Avsar, Melike; Bircan, Rifat; Claus, Maren; Sahin, Serap; Sezgin, Ozlem; Deyneli, Oguzhan; Paschke, Ralf; Cirakoglu, Beyazit; Akalin, Sema

2005-04-01

Autonomously functioning thyroid nodules (AFTNs) can present as hyperfunctioning adenomas or toxic multinodular goiters. In the last decade, a large number of activating mutations have been identified in the thyrotropin receptor (TSHR) gene in autonomously functioning thyroid nodules. Most have been situated close to, or within the sixth transmembrane segment and third intracellular loop of the TSHR where the receptor interacts with the Gs protein. In this study we describe two novel mutations in the sixth transmembrane segment of the TSHR causing hyperfunctioning thyroid nodules. Genomic DNAs were isolated from four hyperfunctioning thyroid nodules, normal tissues and peripheral leukocytes of two patients with toxic multinodular goiter. After amplifying the related regions, TSHR and G(s)alpha genes were analyzed by single-strand conformation polymorphism (SSCP) analysis. The precise localization of the mutations was identified by automatic DNA sequence analysis. Functional studies were done by site-directed mutagenesis and transfection of a mutant construct into COS-7 cells. We identified two novel TSHR mutations in two hyperfunctioning thyroid nodules: Phe631Val in the first patient and Iso630Met in the second patient. Both mutant receptors display an increase in constitutive stimulation of basal cyclic adenosine monophosphate (cAMP) levels compared to the wild-type receptor. This confirms that these mutant receptors cause hyperfunctioning thyroid nodules.

CRISPR/Cas9-Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development.

PubMed

Okoli, Arinze; Okeke, Malachy I; Tryland, Morten; Moens, Ugo

2018-01-22

The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector Nucleases) and ZFNs (Zinc Finger Nucleases) in genome editing of viruses. CRISPR/Cas9 is presently being applied in constructing viral mutants, preventing virus infections, eradicating proviral DNA, and inhibiting viral replication in infected cells. The successful adaptation of CRISPR/Cas9 to editing the genome of Vaccinia virus paves the way for its application in editing other vaccine/vector-relevant orthopoxvirus (OPXV) strains. Thus, CRISPR/Cas9 can be used to resolve some of the major hindrances to the development of OPXV-based recombinant vaccines and vectors, including sub-optimal immunogenicity; transgene and genome instability; reversion of attenuation; potential of spread of transgenes to wildtype strains and close contacts, which are important biosafety and risk assessment considerations. In this article, we review the published literature on the application of CRISPR/Cas9 in virus genome editing and discuss the potentials of CRISPR/Cas9 in advancing OPXV-based recombinant vaccines and vectors. We also discuss the application of CRISPR/Cas9 in combating viruses of clinical relevance, the limitations of CRISPR/Cas9 and the current strategies to overcome them.

An independent confirmatory factor analysis of the Wechsler Intelligence Scale for Children-fourth Edition (WISC-IV) integrated: what do the process approach subtests measure?

PubMed

Benson, Nicholas; Hulac, David M; Bernstein, Joshua D

2013-09-01

The Wechsler intelligence scale for children--fourth edition (WISC-IV) Integrated contains the WISC-IV core and supplemental subtests along with process approach subtests designed to facilitate a process-oriented approach to score interpretation. The purpose of this study was to examine the extent to which WISC-IV Integrated subtests measure the constructs they are purported to measure. In addition to examining the measurement and scoring model provided in the manual, this study also tested hypotheses regarding Cattell-Horn-Carroll abilities that might be measured along with other substantive questions regarding the factor structure of the WISC-IV Integrated and the nature of abilities measured by process approach subtests. Results provide insight regarding the constructs measured by these subtests. Many subtests appear to be good to excellent measures of psychometric g (i.e., the general factor presumed to cause the positive correlation of mental tasks). Other abilities measured by subtests are described. For some subtests, the majority of variance is not accounted for by theoretical constructs included in the scoring model. Modifications made to remove demands such as memory recall and verbal expression were found to reduce construct-irrelevant variance. The WISC-IV Integrated subtests appear to measure similar constructs across ages 6-16, although strict factorial invariance was not supported.

Vacuum polarization of the quantized massive fields in Friedman-Robertson-Walker spacetime

NASA Astrophysics Data System (ADS)

Matyjasek, Jerzy; Sadurski, Paweł; Telecka, Małgorzata

2014-04-01

The stress-energy tensor of the quantized massive fields in a spatially open, flat, and closed Friedman-Robertson-Walker universe is constructed using the adiabatic regularization (for the scalar field) and the Schwinger-DeWitt approach (for the scalar, spinor, and vector fields). It is shown that the stress-energy tensor calculated in the sixth adiabatic order coincides with the result obtained from the regularized effective action, constructed from the heat kernel coefficient a3. The behavior of the tensor is examined in the power-law cosmological models, and the semiclassical Einstein field equations are solved exactly in a few physically interesting cases, such as the generalized Starobinsky models.

Kazachstania Zubkova (1971)

USDA-ARS?s Scientific Manuscript database

This chapter describes the ascomycete yeast genus Kazachstania and is to be published in "The Yeasts, A Taxonomic Study, 5th edition." The genus Kazachstania is newly described and was constructed from certain species previously assigned to the genera Saccharomyces, Kluyveromyces and Arxozyma follo...

Supporting inquiry learning by promoting normative understanding of multivariable causality

NASA Astrophysics Data System (ADS)

Keselman, Alla

2003-11-01

Early adolescents may lack the cognitive and metacognitive skills necessary for effective inquiry learning. In particular, they are likely to have a nonnormative mental model of multivariable causality in which effects of individual variables are neither additive nor consistent. Described here is a software-based intervention designed to facilitate students' metalevel and performance-level inquiry skills by enhancing their understanding of multivariable causality. Relative to an exploration-only group, sixth graders who practiced predicting an outcome (earthquake risk) based on multiple factors demonstrated increased attention to evidence, improved metalevel appreciation of effective strategies, and a trend toward consistent use of a controlled comparison strategy. Sixth graders who also received explicit instruction in making predictions based on multiple factors showed additional improvement in their ability to compare multiple instances as a basis for inferences and constructed the most accurate knowledge of the system. Gains were maintained in transfer tasks. The cognitive skills and metalevel understanding examined here are essential to inquiry learning.

Knowledge Acquisition for Expert Systems in Construction.

DTIC Science & Technology

1988-02-01

Trmble R J Aliwood A E Bryman C N Cooper -. Sixth interim report 4r " -Contract DAJA 45-85-C-0033 February 1988 i i 88 3 09 124 "I...Wheeler, has developed a experienced knowlae engineer Successful applications of expert sys- system for material selection of boier researching at...wanted to try engineer who may suddexiy become very also benefitted from application of artifi- the technology for some time, and his busy on a

Wechsler Intelligence Scale for Children-V: Test Review.

PubMed

Na, Sabrina D; Burns, Thomas G

2016-01-01

Changes from the fourth edition of the Wechsler Intelligence Scale for Children (WISC) to the fifth edition are discussed, with particular emphasis on how the electronic administration facilitated assessment. The hierarchical organization and conceptualization of primary indices have been adjusted, based on recent theory and research on the construct of intelligence. Changes also include updates to psychometric properties and consideration of cultural bias. The scoring program allows intelligence scores to be linked statistically to achievement measures to aid in diagnoses of learning disabilities. Electronic assessment was clunky at times but overall delivered on its promise of quicker and more accurate administration and scoring.

A professional and cost effective digital video editing and image storage system for the operating room.

PubMed

Scollato, A; Perrini, P; Benedetto, N; Di Lorenzo, N

2007-06-01

We propose an easy-to-construct digital video editing system ideal to produce video documentation and still images. A digital video editing system applicable to many video sources in the operating room is described in detail. The proposed system has proved easy to use and permits one to obtain videography quickly and easily. Mixing different streams of video input from all the devices in use in the operating room, the application of filters and effects produces a final, professional end-product. Recording on a DVD provides an inexpensive, portable and easy-to-use medium to store or re-edit or tape at a later time. From stored videography it is easy to extract high-quality, still images useful for teaching, presentations and publications. In conclusion digital videography and still photography can easily be recorded by the proposed system, producing high-quality video recording. The use of firewire ports provides good compatibility with next-generation hardware and software. The high standard of quality makes the proposed system one of the lowest priced products available today.

CRISPR-Cas9 Toolkit for Actinomycete Genome Editing.

PubMed

Tong, Yaojun; Robertsen, Helene Lunde; Blin, Kai; Weber, Tilmann; Lee, Sang Yup

2018-01-01

Bacteria of the order Actinomycetales are one of the most important sources of bioactive natural products, which are the source of many drugs. However, many of them still lack efficient genome editing methods, some strains even cannot be manipulated at all. This restricts systematic metabolic engineering approaches for boosting known and discovering novel natural products. In order to facilitate the genome editing for actinomycetes, we developed a CRISPR-Cas9 toolkit with high efficiency for actinomyces genome editing. This basic toolkit includes a software for spacer (sgRNA) identification, a system for in-frame gene/gene cluster knockout, a system for gene loss-of-function study, a system for generating a random size deletion library, and a system for gene knockdown. For the latter, a uracil-specific excision reagent (USER) cloning technology was adapted to simplify the CRISPR vector construction process. The application of this toolkit was successfully demonstrated by perturbation of genomes of Streptomyces coelicolor A3(2) and Streptomyces collinus Tü 365. The CRISPR-Cas9 toolkit and related protocol described here can be widely used for metabolic engineering of actinomycetes.

Interactions of cultures and top people of Wikipedia from ranking of 24 language editions.

PubMed

Eom, Young-Ho; Aragón, Pablo; Laniado, David; Kaltenbrunner, Andreas; Vigna, Sebastiano; Shepelyansky, Dima L

2015-01-01

Wikipedia is a huge global repository of human knowledge that can be leveraged to investigate interwinements between cultures. With this aim, we apply methods of Markov chains and Google matrix for the analysis of the hyperlink networks of 24 Wikipedia language editions, and rank all their articles by PageRank, 2DRank and CheiRank algorithms. Using automatic extraction of people names, we obtain the top 100 historical figures, for each edition and for each algorithm. We investigate their spatial, temporal, and gender distributions in dependence of their cultural origins. Our study demonstrates not only the existence of skewness with local figures, mainly recognized only in their own cultures, but also the existence of global historical figures appearing in a large number of editions. By determining the birth time and place of these persons, we perform an analysis of the evolution of such figures through 35 centuries of human history for each language, thus recovering interactions and entanglement of cultures over time. We also obtain the distributions of historical figures over world countries, highlighting geographical aspects of cross-cultural links. Considering historical figures who appear in multiple editions as interactions between cultures, we construct a network of cultures and identify the most influential cultures according to this network.

Interactions of Cultures and Top People of Wikipedia from Ranking of 24 Language Editions

PubMed Central

Eom, Young-Ho; Aragón, Pablo; Laniado, David; Kaltenbrunner, Andreas; Vigna, Sebastiano; Shepelyansky, Dima L.

2015-01-01

Wikipedia is a huge global repository of human knowledge that can be leveraged to investigate interwinements between cultures. With this aim, we apply methods of Markov chains and Google matrix for the analysis of the hyperlink networks of 24 Wikipedia language editions, and rank all their articles by PageRank, 2DRank and CheiRank algorithms. Using automatic extraction of people names, we obtain the top 100 historical figures, for each edition and for each algorithm. We investigate their spatial, temporal, and gender distributions in dependence of their cultural origins. Our study demonstrates not only the existence of skewness with local figures, mainly recognized only in their own cultures, but also the existence of global historical figures appearing in a large number of editions. By determining the birth time and place of these persons, we perform an analysis of the evolution of such figures through 35 centuries of human history for each language, thus recovering interactions and entanglement of cultures over time. We also obtain the distributions of historical figures over world countries, highlighting geographical aspects of cross-cultural links. Considering historical figures who appear in multiple editions as interactions between cultures, we construct a network of cultures and identify the most influential cultures according to this network. PMID:25738291

Journal of Special Operations Medicine, Volume 3, Edition 3

DTIC Science & Technology

2003-01-01

focuses on the basic design, construction, uti - lization, components, and nomenclature associated with the ICS. Objectives: 1. Maximize the overall...TX 76134 9. American Society of Health-System Pharmacists : AHFS Drug Information. Bethesda, Maryland; 2002:1305 Journal of Special Operations

CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development

PubMed Central

Okoli, Arinze; Okeke, Malachy I.; Tryland, Morten; Moens, Ugo

2018-01-01

The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector Nucleases) and ZFNs (Zinc Finger Nucleases) in genome editing of viruses. CRISPR/Cas9 is presently being applied in constructing viral mutants, preventing virus infections, eradicating proviral DNA, and inhibiting viral replication in infected cells. The successful adaptation of CRISPR/Cas9 to editing the genome of Vaccinia virus paves the way for its application in editing other vaccine/vector-relevant orthopoxvirus (OPXV) strains. Thus, CRISPR/Cas9 can be used to resolve some of the major hindrances to the development of OPXV-based recombinant vaccines and vectors, including sub-optimal immunogenicity; transgene and genome instability; reversion of attenuation; potential of spread of transgenes to wildtype strains and close contacts, which are important biosafety and risk assessment considerations. In this article, we review the published literature on the application of CRISPR/Cas9 in virus genome editing and discuss the potentials of CRISPR/Cas9 in advancing OPXV-based recombinant vaccines and vectors. We also discuss the application of CRISPR/Cas9 in combating viruses of clinical relevance, the limitations of CRISPR/Cas9 and the current strategies to overcome them. PMID:29361752

Mutagenesis and Genome Engineering of Epstein-Barr Virus in Cultured Human Cells by CRISPR/Cas9.

PubMed

Yuen, Kit-San; Chan, Chi-Ping; Kok, Kin-Hang; Jin, Dong-Yan

2017-01-01

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 nuclease (Cas9) system is a powerful genome-editing tool for both chromosomal and extrachromosomal DNA. DNA viruses such as Epstein-Barr virus (EBV), which undergoes episomal replication in human cells, can be effectively edited by CRISPR/Cas9. We have demonstrated targeted editing of the EBV genome by CRISPR/Cas9 in several lines of EBV-infected cells. CRISPR/Cas9-based mutagenesis and genome engineering of EBV provides a new method for genetic analysis, which has some advantages over bacterial artificial chromosome-based recombineering. This approach might also prove useful in the cure of EBV infection. In this chapter, we use the knockout of the BART promoter as an example to detail the experimental procedures for construction of recombinant EBV in human cells.

Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.

PubMed

Nuñez, James K; Harrington, Lucas B; Doudna, Jennifer A

2016-03-18

The application of the CRISPR-Cas9 system for genome engineering has revolutionized the ability to interrogate genomes of mammalian cells. Programming the Cas9 endonuclease to induce DNA breaks at specified sites is achieved by simply modifying the sequence of its cognate guide RNA. Although Cas9-mediated genome editing has been shown to be highly specific, cleavage events at off-target sites have also been reported. Minimizing, and eventually abolishing, unwanted off-target cleavage remains a major goal of the CRISPR-Cas9 technology before its implementation for therapeutic use. Recent efforts have turned to chemical biology and biophysical approaches to engineer inducible genome editing systems for controlling Cas9 activity at the transcriptional and protein levels. Here, we review recent advancements to modulate Cas9-mediated genome editing by engineering split-Cas9 constructs, inteins, small molecules, protein-based dimerizing domains, and light-inducible systems.

TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection.

PubMed

Hendriks, William T; Jiang, Xin; Daheron, Laurence; Cowan, Chad A

2015-08-03

Using custom-engineered nuclease-mediated genome editing, such as Transcription Activator-Like Effector Nucleases (TALENs) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) RNA-guided Cas9 nucleases, human pluripotent stem cell (hPSC) lines with knockout or mutant alleles can be generated and differentiated into various cell types. This strategy of genome engineering in hPSCs will prove invaluable for studying human biology and disease. Here, we provide a detailed protocol for design and construction of TALEN and CRISPR vectors, testing of their nuclease activity, and delivery of TALEN or CRISPR vectors into hPSCs. In addition, we describe the use of single-stranded oligodeoxynucleotides (ssODNs) to introduce or repair point mutations. Next, we describe the identification of edited hPSC clones without antibiotic selection, including their clonal selection, genotyping, and expansion for downstream applications. Copyright © 2015 John Wiley & Sons, Inc.

Developmental history and application of CRISPR in human disease.

PubMed

Liang, Puping; Zhang, Xiya; Chen, Yuxi; Huang, Junjiu

2017-06-01

Genome-editing tools are programmable artificial nucleases, mainly including zinc-finger nucleases, transcription activator-like effector nucleases and clustered regularly interspaced short palindromic repeat (CRISPR). By recognizing and cleaving specific DNA sequences, genome-editing tools make it possible to generate site-specific DNA double-strand breaks (DSBs) in the genome. DSBs will then be repaired by either error-prone nonhomologous end joining or high-fidelity homologous recombination mechanisms. Through these two different mechanisms, endogenous genes can be knocked out or precisely repaired/modified. Rapid developments in genome-editing tools, especially CRISPR, have revolutionized human disease models generation, for example, various zebrafish, mouse, rat, pig, monkey and human cell lines have been constructed. Here, we review the developmental history of CRISPR and its application in studies of human diseases. In addition, we also briefly discussed the therapeutic application of CRISPR in the near future. Copyright © 2017 John Wiley & Sons, Ltd.

KSC-00dig067

NASA Image and Video Library

2000-10-31

After repair of a cracked cleat on the crawler-transporter, Space Shuttle Endeavour finally rests on Launch Pad 39B. To the left is the Rotating Service Structure. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig104

NASA Image and Video Library

2000-11-28

STS-97 Mission Specialist Carlos Noriega gets help with his boots from suit technician Shelly Grick-Agrella during pre-pack and fit check. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig108

NASA Image and Video Library

2000-11-28

During pre-pack and fit check in the Operations and Checkout Building, STS-97 Commander Brent Jett gets help with his gloves from suit technician Bill Todd. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig103

NASA Image and Video Library

2000-11-28

STS-97 Mission Specialist Joseph Tanner gets help with his boots from suit technician Erin Canlon during check pre-pack and fit check. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig106

NASA Image and Video Library

2000-11-28

STS-97 Pilot Michael Bloomfield gets help with his boots from suit technician Steve Clendenin during pre-pack and fit check. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

ERTS-1 data as a teaching and research tool in the Department of Geology

NASA Technical Reports Server (NTRS)

Grybeck, D. (Principal Investigator)

1973-01-01

The author has identified the following significant results. During the sixth bi-monthly period, a mosaic was constructed in MSS band 6 of the southeastern one-half of Alaska. A mosaic of the whole state awaits additional coverage to fill in some gaps. In addition, new material is being monitored as it arrived at the Geophysical Institute and from the NASA Indices for inclusion into the departmental collections. No geology courses are being taught during the summer.

Mediator Deathwork

ERIC Educational Resources Information Center

Walter, Tony

2005-01-01

The most discussed and analyzed form of deathwork is the dyadic "therapist" [double arrow] "client" relationship, but this far from exhausts the various types of professional work involving the dead. Mediator deathwork is where the professional gleans or constructs information about the dead, edits and polishes it, and publicly…

Guidance for Preparing a Facility Plan. Revised Edition.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC. Office of Water Programs.

This document provides information to assist with preparing a preliminary facility plan for construction of municipal sewage treatment works. The text describes the requirements in the applicable laws and regulations and suggests a planning process by which they can be met. (CS)

Epistemologies of Ignorance in Education

ERIC Educational Resources Information Center

Malewski, Erik; Jaramillo, Nathalia

2011-01-01

Epistemologies of Ignorance provide educators a distinct epistemological view on questions of marginalization, oppression, relations of power and dominance, difference, philosophy, and even death among our youth. The authors of this edited collection challenge the ambivalence--ignorance--found in the construction of curriculum, teaching practices,…

Residential Construction Trends in America's Metropolitan Regions: 2010 and 2009 Editions

EPA Pesticide Factsheets

These two reports examine residential building permits in the 50 largest U.S. metropolitan regions at the county or jurisdictional level to determine whether there has been a shift toward redevelopment and which regions have seen the most change.

Information-seeking strategies and science content understandings of sixth-grade students using on-line learning environments

NASA Astrophysics Data System (ADS)

Hoffman, Joseph Loris

1999-11-01

This study examined the information-seeking strategies and science content understandings learners developed as a result of using on-line resources in the University of Michigan Digital Library and on the World Wide Web. Eight pairs of sixth grade students from two teachers' classrooms were observed during inquiries for astronomy, ecology, geology, and weather, and a final transfer task assessed learners' capabilities at the end of the school year. Data included video recordings of students' screen activity and conversations, journals and completed activity sheets, final artifacts, and semi-structured interviews. Learners' information-seeking strategies included activities related to asking, planning, tool usage, searching, assessing, synthesizing, writing, and creating. Analysis of data found a majority of learners posed meaningful, openended questions, used technological tools appropriately, developed pertinent search topics, were thoughtful in queries to the digital library, browsed sites purposefully to locate information, and constructed artifacts with novel formats. Students faced challenges when planning activities, assessing resources, and synthesizing information. Possible explanations were posed linking pedagogical practices with learners' growth and use of inquiry strategies. Data from classroom-lab video and teacher interviews showed varying degrees of student scaffolding: development and critique of initial questions, utilization of search tools, use of journals for reflection on activities, and requirements for final artifacts. Science content understandings included recalling information, offering explanations, articulating relationships, and extending explanations. A majority of learners constructed partial understandings limited to information recall and simple explanations, and these occasionally contained inaccurate conceptualizations. Web site design features had some influence on the construction of learners' content understandings. Analysis of data suggests sites with high quality general design, navigation, and content helped to foster the construction of broad and accurate understandings, while context and interactivity had less impact. However, student engagement with inquiry strategies had a greater impact on the construction of understandings. Gaining accurate and in-depth understandings from on-line resources is a complex process for young learners. Teachers can support students by helping them engage in all phases of the information-seeking process, locate useful information with prescreened resources, build background understanding with off-line instruction, and process new information deeply through extending writing and conversation.

Pilot ejection, parachute, and helicopter crash injuries.

PubMed

McBratney, Colleen M; Rush, Stephen; Kharod, Chetan U

2014-01-01

USAF Pararescuemen (PJs) respond to downed aircrew as a fundamental mission for personnel recovery (PR), one of the Air Force's core functions. In addition to responding to these in Military settings, the PJs from the 212 Rescue Squadron routinely respond to small plane crashes in remote regions of Alaska. While there is a paucity of information on the latter, there have been articles detailing injuries sustained from helicopter crashes and while ejecting or parachuting from fixed wing aircraft. The following represents a new chapter added to the Pararescue Medical Operations Handbook, Sixth Edition (2014, editors Matt Wolf, MD, and Stephen Rush, MD, in press). It was designed to be a quick reference for PJs and their Special Operations flight surgeons to help with understanding of mechanism of injury with regard to pilot ejection, parachute, and helicopter accident injuries. It outlines the nature of the injuries sustained in such mishaps and provides an epidemiologic framework from which to approach the problem. 2014.

Students' perceptions of Roundhouse diagramming: a middle-school viewpoint

NASA Astrophysics Data System (ADS)

Ward, Robin E.; Wandersee, James H.

2002-02-01

This multiple case study explored the effects of Roundhouse diagram construction and use on meaningful learning of science concepts in a sixth-grade classroom. The investigation examined three issues: (1) the transformation of students' science conceptions as they become more proficient in constructing Roundhouse diagrams; (2) problems students encountered using this technique; and (3) the effect of choices of iconic images on their progress toward meaningfully learning science concepts. A Roundhouse diagram is a graphic representation of a learner's conceptual understanding regarding a predetermined science topic. This method involves recognizing the main ideas within a science lesson, breaking down the information into interrelated segments, and then linking each portion to an iconic image. These students typically gained a greater understanding of science explanations by constructing the diagrams. Student's science scores improved over the 10-week diagramming period and a positive relationship existed between students' choices and drawings of iconic images and the meaningful learning of science topics.

Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9.

PubMed

Everman, Jamie L; Rios, Cydney; Seibold, Max A

2018-01-01

The adaptation of the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated endonuclease 9 (CRISPR-Cas9) machinery from prokaryotic organisms has resulted in a gene editing system that is highly versatile, easily constructed, and can be leveraged to generate human cells knocked out (KO) for a specific gene. While standard transfection techniques can be used for the introduction of CRISPR-Cas9 expression cassettes to many cell types, delivery by this method is not efficient in many primary cell types, including primary human airway epithelial cells (AECs). More efficient delivery in AECs can be achieved through lentiviral-mediated transduction, allowing the CRISPR-Cas9 system to be integrated into the genome of the cell, resulting in stable expression of the nuclease machinery and increasing editing rates. In parallel, advancements have been made in the culture, expansion, selection, and differentiation of AECs, which allow the robust generation of a bulk edited AEC population from transduced cells. Applying these methods, we detail here our latest protocol to generate mucociliary epithelial cultures knocked out for a specific gene from donor-isolated primary human basal airway epithelial cells. This protocol includes methods to: (1) design and generate lentivirus which targets a specific gene for KO with CRISPR-Cas9 machinery, (2) efficiently transduce AECs, (3) culture and select for a bulk edited AEC population, (4) molecularly screen AECs for Cas9 cutting and specific sequence edits, and (5) further expand and differentiate edited cells to a mucociliary airway epithelial culture. The AEC knockouts generated using this protocol provide an excellent primary cell model system with which to characterize the function of genes involved in airway dysfunction and disease.

TALEN-Mediated Homologous Recombination Produces Site-Directed DNA Base Change and Herbicide-Resistant Rice.

PubMed

Li, Ting; Liu, Bo; Chen, Chih Ying; Yang, Bing

2016-05-20

Over the last decades, much endeavor has been made to advance genome editing technology due to its promising role in both basic and synthetic biology. The breakthrough has been made in recent years with the advent of sequence-specific endonucleases, especially zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPRs) guided nucleases (e.g., Cas9). In higher eukaryotic organisms, site-directed mutagenesis usually can be achieved through non-homologous end-joining (NHEJ) repair to the DNA double-strand breaks (DSBs) caused by the exogenously applied nucleases. However, site-specific gene replacement or genuine genome editing through homologous recombination (HR) repair to DSBs remains a challenge. As a proof of concept gene replacement through TALEN-based HR in rice (Oryza sativa), we successfully produced double point mutations in rice acetolactate synthase gene (OsALS) and generated herbicide resistant rice lines by using TALENs and donor DNA carrying the desired mutations. After ballistic delivery into rice calli of TALEN construct and donor DNA, nine HR events with different genotypes of OsALS were obtained in T0 generation at the efficiency of 1.4%-6.3% from three experiments. The HR-mediated gene edits were heritable to the progeny of T1 generation. The edited T1 plants were as morphologically normal as the control plants while displayed strong herbicide resistance. The results demonstrate the feasibility of TALEN-mediated genome editing in rice and provide useful information for further genome editing by other nuclease-based genome editing platforms. Copyright © 2016 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Efficient genome editing of wild strawberry genes, vector development and validation.

PubMed

Zhou, Junhui; Wang, Guoming; Liu, Zhongchi

2018-03-25

The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is an effective genome editing tool for plant and animal genomes. However, there are still few reports on the successful application of CRISPR-Cas9 to horticultural plants, especially with regard to germ-line transmission of targeted mutations. Here, we report high-efficiency genome editing in the wild strawberry Fragaria vesca and its successful application to mutate the auxin biosynthesis gene TAA1 and auxin response factor 8 (ARF8). In our CRISPR system, the Arabidopsis U6 promoter AtU6-26 and the wild strawberry U6 promoter FveU6-2 were each used to drive the expression of sgRNA, and both promoters were shown to lead to high-efficiency genome editing in strawberry. To test germ-line transmission of the edited mutations and new mutations induced in the next generation, the progeny of the primary (T0) transgenic plants carrying the CRISPR construct was analysed. New mutations were detected in the progeny plants at a high efficiency, including large deletions between the two PAM sites. Further, T1 plants harbouring arf8 homozygous knockout mutations grew considerably faster than wild-type plants. The results indicate that our CRISPR vectors can be used to edit the wild strawberry genome at a high efficiency and that both sgRNA design and appropriate U6 promoters contribute to the success of genomic editing. Our results open up exciting opportunities for engineering strawberry and related horticultural crops to improve traits of economic importance. © 2018 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

Analysis of Low Bidding and Change Order Rates for Navy Facilities Construction Contracts.

DTIC Science & Technology

1984-06-01

examine his motives and strategies prior to bidding. Several measures of " level cf competitiveness" are introduced from bidding theory literature that...bidders of fixed-price Government construction contracts have on contract prices when the level FORM, 1473 EDITION OF INOV 6 o IS OBSOLETE S N 0 102...conventional measures of the . level of competition intensity are applied in regression and variance analyses. en, z e ., . , 144 , UNCLASSIFIED 2 SgCURITlY

Pathological Gambling Subtypes

ERIC Educational Resources Information Center

Vachon, David D.; Bagby, R. Michael

2009-01-01

Although pathological gambling (PG) is regarded in the 4th edition of the "Diagnostic and Statistical Manual of Mental Disorders" (American Psychiatric Association, 1994) as a unitary diagnostic construct, it is likely composed of distinct subtypes. In the current report, the authors used cluster analyses of personality traits with a…

Commercial Carpentry. Instructor Edition.

ERIC Educational Resources Information Center

Hendrix, Laborn J.

This teaching guide is intended to combine practical experience in the construction industry with the teaching methods of vocational education for instruction in carpentry. Instructional material in this manual is written in terms of student performance, using measurable behavioral objectives. This guide contains 4 sections organized in 24…

In vivo and in vitro disease modeling with CRISPR/Cas9.

PubMed

Kato, Tomoko; Takada, Shuji

2017-01-01

In the past few years, extensive progress has been made in the development of genome-editing technology. Among several genome-editing tools, the clustered regularly interspaced short palindrome repeat-associated Cas9 nuclease (CRISPR/Cas9) system is particularly widely used owing to the ease of sequence-specific nuclease construction and the highly efficient introduction of mutations. The CRISPR/Cas9 system was originally constructed to induce small insertion and deletion mutations, but various methods have been developed to introduce point mutations, deletions, insertions, chromosomal translocations and so on. These methods should be useful for the reconstruction of disease-causing mutations in cultured cell lines and living organisms to elucidate disease pathogenesis and for disease prevention, treatment and drug discovery. This review summarizes the current technical aspects of the CRISPR/Cas9 system for disease modeling in cultured cells and living organisms, mainly mice. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

View of substructure of Sixth Street Bridge overcrossing of Los ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of substructure of Sixth Street Bridge overcrossing of Los Angeles River. Looking west. Note dark hole at lower with is access ramp to river channel seen in HAER CA-176-56 - Sixth Street Bridge, Spanning 101 Freeway at Sixth Street, Los Angeles, Los Angeles County, CA

8 CFR 212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

Code of Federal Regulations, 2011 CFR

2011-01-01

... certain derivative third and sixth preference and nonpreference immigrants. 212.9 Section 212.9 Aliens and... certain derivative third and sixth preference and nonpreference immigrants. A derivative beneficiary who... medical profession. Therefore, a derivative third or sixth preference or nonpreference immigrant under...

A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1.

PubMed

Wang, Yuru; Havel, Jocelyn; Beal, Peter A

2015-11-20

Adenosine deaminases acting on RNA (ADARs) are RNA-editing enzymes responsible for the conversion of adenosine to inosine at specific locations in cellular RNAs. ADAR1 and ADAR2 are two members of the family that have been shown to be catalytically active. Earlier, we reported a phenotypic screen for the study of human ADAR2 using budding yeast S. cerevisiae as the host system. While this screen has been successfully applied to the study of ADAR2, it failed with ADAR1. Here, we report a new reporter that uses a novel editing substrate and is suitable for the study of ADAR1. We screened plasmid libraries with randomized codons for two important residues in human ADAR1 (G1007 and E1008). The screening results combined with in vitro deamination assays led to the identification of mutants that are more active than the wild type protein. Furthermore, a screen of the ADAR1 E1008X library with a reporter construct bearing an A•G mismatch at the editing site suggests one role for the residue at position 1008 is to sense the identity of the base pairing partner for the editing site adenosine. This work has provided a starting point for future in vitro evolution studies of ADAR1 and led to new insight into ADAR's editing site selectivity.

Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid.

PubMed

Juergens, Hannes; Varela, Javier A; Gorter de Vries, Arthur R; Perli, Thomas; Gast, Veronica J M; Gyurchev, Nikola Y; Rajkumar, Arun S; Mans, Robert; Pronk, Jack T; Morrissey, John P; Daran, Jean-Marc G

2018-05-01

While CRISPR-Cas9-mediated genome editing has transformed yeast research, current plasmids and cassettes for Cas9 and guide-RNA expression are species specific. CRISPR tools that function in multiple yeast species could contribute to the intensifying research on non-conventional yeasts. A plasmid carrying a pangenomic origin of replication and two constitutive expression cassettes for Cas9 and ribozyme-flanked gRNAs was constructed. Its functionality was tested by analyzing inactivation of the ADE2 gene in four yeast species. In two Kluyveromyces species, near-perfect targeting (≥96%) and homologous repair (HR) were observed in at least 24% of transformants. In two Ogataea species, Ade- mutants were not observed directly after transformation, but prolonged incubation of transformed cells resulted in targeting efficiencies of 9% to 63% mediated by non-homologous end joining (NHEJ). In an Ogataea parapolymorpha ku80 mutant, deletion of OpADE2 mediated by HR was achieved, albeit at low efficiencies (<1%). Furthermore the expression of a dual polycistronic gRNA array enabled simultaneous interruption of OpADE2 and OpYNR1 demonstrating flexibility of ribozyme-flanked gRNA design for multiplexing. While prevalence of NHEJ prevented HR-mediated editing in Ogataea, such targeted editing was possible in Kluyveromyces. This broad-host-range CRISPR/gRNA system may contribute to exploration of Cas9-mediated genome editing in other Saccharomycotina yeasts.

Depressive Personality Disorder: A Comparison of Three Self-Report Measures

ERIC Educational Resources Information Center

Miller, Joshua D.; Tant, Adam; Bagby, R. Michael

2010-01-01

Depressive personality disorder (DPD) was included in the appendix of the "Diagnostic and Statistical Manual of Mental Disorders", Fourth Edition ("DSM-IV") for further study. Questions abound regarding this disorder in terms of its distinctiveness from extant diagnostic constructs and clinical significance.This study examines…

A Model Framework for Course Materials Construction (Second Edition).

ERIC Educational Resources Information Center

Schlenker, Richard M.

Designed for use by Coast Guard course writers, curriculum developers, course coordinators, and instructors as a decision-support system, this publication presents a model that translates the Intraservices Procedures for Instructional Systems Development curriculum design model into materials usable by classroom teachers and students. Although…

The Asphalt Handbook.

ERIC Educational Resources Information Center

Asphalt Inst., College Park, MD.

The new and completely revised edition of the Asphalt Handbook, a standard reference work in the field of asphalt technology and construction, summarizes with reference the information contained in other Asphalt Institute technical manuals. Major areas discussed include the following--(1) uses of asphalt, (2) terms relating to asphalt and its…

LSCA Final Reports: Second Series.

ERIC Educational Resources Information Center

Clark, Collin, Ed.

This document includes final summary reports from recent federally funded Library Services and Construction Act (LSCA) demonstration projects in California. While some projects reported at length and others provided the bare facts, reports are excerpted but published as received, without editing beyond a uniform first page. The Summary Report Form…

Two Distinct Approaches for CRISPR-Cas9-Mediated Gene Editing in Cryptococcus neoformans and Related Species.

PubMed

Wang, Ping

2018-06-27

Cryptococcus neoformans and related species are encapsulated basidiomycetous fungi that cause meningoencephalitis in individuals with immune deficiency. This pathogen has a tractable genetic system; however, gene disruption via electroporation remains difficult, while biolistic transformation is often limited by lack of multiple genetic markers and the high initial cost of equipment. The approach using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) has become the technology of choice for gene editing in many organisms due to its simplicity, efficiency, and versatility. The technique has been successfully demonstrated in C. neoformans and Cryptococcus deneoformans in which two DNA plasmids expressing either the Streptococcus pyogenes CAS9 gene or the guide RNA (gRNA) were employed. However, potential adverse effects due to constitutive expression and the time-consuming process of constructing vectors to express each gRNA remain as a primary barrier for wide adaptation. This report describes the delivery of preassembled CRISPR-Cas9-gRNA ribonucleoproteins (RNPs) via electroporation that is able to generate edited mutant alleles. RNP-mediated CRISPR-Cas9 was used to replace the wild-type GIB2 gene encoding a Gβ-like/RACK1 Gib2 protein with a gib2 :: NAT allele via homologous recombination in both C. neoformans and C. deneoformans In addition, a DNA plasmid (pCnCas9:U6-gRNA) that expresses both Cas9 and gRNA, allowing for convenient yet low-cost DNA-mediated gene editing, is described. pCnCas9:U6-gRNA contains an endogenous U6 promoter for gRNA expression and restriction sites for one-step insertion of a gRNA. These approaches and resources provide new opportunities to accelerate genetic studies of Cryptococcus species. IMPORTANCE For genetic studies of the Cryptococcus genus, generation of mutant strains is often hampered by a limited number of selectable genetic markers, the tedious process of vector construction, side effects, and other limitations, such as the high cost of acquiring a particle delivery system. CRISPR-Cas9 technology has been demonstrated in Cryptococcus for genome editing. However, it remains labor-intensive and time-consuming since it requires the identification of a suitable type III RNA polymerase promoter for gRNA expression. In addition, there may be potential adverse effects caused by constitutive expressions of Cas9 and gRNA. Here, I report the use of a ribonucleoprotein-mediated CRISPR-Cas9 technique for genome editing of C. neoformans and related species. Together with the custom-constructed pCnCas9:U6-gRNA vector that allows low-cost and time-saving DNA-based CRISPR-Cas9, my approach adds to the molecular toolbox for dissecting the molecular mechanism of pathogenesis in this important group of fungal pathogens. Copyright © 2018 Wang.

Efficient CRISPR/Cas9 Genome Editing of Phytoene desaturase in Cassava.

PubMed

Odipio, John; Alicai, Titus; Ingelbrecht, Ivan; Nusinow, Dmitri A; Bart, Rebecca; Taylor, Nigel J

2017-01-01

CRISPR/Cas9 has become a powerful genome-editing tool for introducing genetic changes into crop species. In order to develop capacity for CRISPR/Cas9 technology in the tropical staple cassava ( Manihot esculenta ), the Phytoene desaturase ( MePDS ) gene was targeted in two cultivars using constructs carrying gRNAs targeting two sequences within MePDS exon 13. After Agrobacterium -mediated delivery of CRISPR/Cas9 reagents into cassava cells, both constructs induced visible albino phenotypes within cotyledon-stage somatic embryos regenerating on selection medium and the plants regenerated therefrom. A total of 58 (cv. 60444) and 25 (cv. TME 204) plant lines were recovered, of which 38 plant lines (19 from each cultivar) were analyzed for mutagenesis. The frequency of plant lines showing albino phenotype was high, ranging from 90 to 100% in cv. TME 204. Observed albino phenotypes were comprised of full albinos devoid of green tissue and chimeras containing a mixture of white and green tissues. Sequence analysis revealed that 38/38 (100%) of the plant lines examined carried mutations at the targeted MePDS site, with insertions, deletions, and substitutions recorded. One putatively mono-allelic homozygous line (1/19) was found from cv. 60444, while 1 (1/19) and 4 (4/19) putatively bi-allelic homozygous lines were found in 60444 and TME204, respectively. The remaining plant lines, comprised mostly of the chimeras, were found to be putatively heterozygous. We observed minor (1 bp) nucleotide substitutions and or deletions upstream of the 5' and or downstream of the 3' targeted MePDS region. The data reported demonstrates that CRISPR/Cas9-mediated genome editing of cassava is highly efficient and relatively simple, generating multi-allelic mutations in both cultivars studied. Modification of MePDS described here generates visually detectable mutated events in a relatively short time frame of 6-8 weeks, and does not require sequencing to confirm editing at the target. It therefore provides a valuable platform to facilitate rapid assessment and optimization of CRISPR/Cas9 and other genome-editing technologies in cassava.

8 CFR 212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

Code of Federal Regulations, 2010 CFR

2010-01-01

... certain derivative third and sixth preference and nonpreference immigrants. 212.9 Section 212.9 Aliens and... certain derivative third and sixth preference and nonpreference immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who is...

8 CFR 1212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

Code of Federal Regulations, 2011 CFR

2011-01-01

... certain derivative third and sixth preference and nonpreference immigrants. 1212.9 Section 1212.9 Aliens... Applicability of section 212(a)(32) to certain derivative third and sixth preference and nonpreference immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or...

Prospective Mathematics Teachers' Ability to Identify Mistakes Related to Angle Concept of Sixth Grade Students

ERIC Educational Resources Information Center

Arslan, Cigdem; Erbay, Hatice Nur; Guner, Pinar

2017-01-01

In the present study we try to highlight prospective mathematics teachers' ability to identify mistakes of sixth grade students related to angle concept. And also we examined prospective mathematics teachers' knowledge of angle concept. Study was carried out with 30 sixth-grade students and 38 prospective mathematics teachers. Sixth grade students…

RSRA sixth scale wind tunnel test. [of scale model of Sikorsky Whirlwind Helicopter

NASA Technical Reports Server (NTRS)

Flemming, R.; Ruddell, A.

1974-01-01

The sixth scale model of the Sikorsky/NASA/Army rotor systems research aircraft was tested in an 18-foot section of a large subsonic wind tunnel for the purpose of obtaining basic data in the areas of performance, stability, and body surface loads. The model was mounted in the tunnel on the struts arranged in tandem. Basic testing was limited to forward flight with angles of yaw from -20 to +20 degrees and angles of attack from -20 to +25 degrees. Tunnel test speeds were varied up to 172 knots (q = 96 psf). Test data were monitored through a high speed static data acquisition system, linked to a PDP-6 computer. This system provided immediate records of angle of attack, angle of yaw, six component force and moment data, and static and total pressure information. The wind tunnel model was constructed of aluminum structural members with aluminum, fiberglass, and wood skins. Tabulated force and moment data, flow visualization photographs, tabulated surface pressure data are presented for the basic helicopter and compound configurations. Limited discussions of the results of the test are included.

Environmental Assessment for Tower Construction at the Brandywine Communication Receiver Site, Prince George’s County, Maryland

DTIC Science & Technology

2005-05-01

mobilization . • Place1nent of tower guy wires will be adjusted to avoid construction and disturbance to any wetlands or small tributaries through on...include combustion emissions (VOC, NOx, CO, SO2) and fugitive dust (PM10) from mobile heavy-duty diesel- and gasoline-powered equipment and soil...Pollutant Factors, Mobile Sources (AP 42). 4th Edition, U.S. Environmental Protection Agency, Ann Arbor, Michigan. Total estimated emissions for VOC and

A Practical Guide to the Design and Construction of a Single Wire Beverage Antenna.

DTIC Science & Technology

1980-09-01

THEORETICAL PATTERNS 5 5 DESIGN PARAMETERS 7 6 ANTENNA CONSTRUCTION 8 7 ASSESSMENT OF PERFORMANCE 9 8 CONCLUSIONS 9 Tables 1-4 11 References 14...on the main RAE 1906S computer. > The results show the effect at two frequencies of varying the main parameters of antenna height, antenna length...programmes are stored on the main RAE 1906S computer and can be edited prior to running to take into account desired changes in parameters , principally

Central Florida Film Production Technology Training Program. Curriculum.

ERIC Educational Resources Information Center

Valencia Community Coll., Orlando, FL.

The Central Florida Film Production Technology Training program provided training to prepare 134 persons for employment in the motion picture industry. Students were trained in stagecraft, sound, set construction, camera/editing, and post production. The project also developed a curriculum model that could be used for establishing an Associate in…

Bridges. A Physics Unit for 14/15 Year Old Students. Experimental Edition.

ERIC Educational Resources Information Center

Utrecht State Univ., (Netherlands).

Bridges and similar constructions are highlighted in this book of guided lessons and activities for secondary school physics students. This program was developed by the Physics Curriculum Development Project under the auspices of the Physics Curriculum Innovation Committee. Contents include: (1) "Introduction" (presenting a rationale for…

Mountain Plains Learning Experience Guide: Drafting. Course: Basic Drawing. Revised Edition.

ERIC Educational Resources Information Center

Wetterling, C.; Wheatley, J.

One of two individualized courses included in a drafting curriculum, this course is designed to develop the fundamental skills of drafting using mechanical instruments. The course is comprised of thirteen units: (1) Mechanical Drawing, (2) Lettering, (3) Geometric Construction, (4) Shape Description, (5) Multiview Projection and Drawing…

Annotated Bibliography for Water Quality Management, Fifth Edition.

ERIC Educational Resources Information Center

Environmental Protection Agency, Washington, DC. Office of Water Programs.

The references included in this bibliography have been selected by the Environmental Protection Agency for their applicability to 208 planning and for their availability. Each reference is followed by a short abstract and when possible by detailed price and ordering information. Topic areas include: agriculture, construction, economics, impact…

Towards an Intelligent Planning Knowledge Base Development Environment

NASA Technical Reports Server (NTRS)

Chien, S.

1994-01-01

ract describes work in developing knowledge base editing and debugging tools for the Multimission VICAR Planner (MVP) system. MVP uses artificial intelligence planning techniques to automatically construct executable complex image processing procedures (using models of the smaller constituent image processing requests made to the JPL Multimission Image Processing Laboratory.

42 CFR 416.44 - Condition for coverage-Environment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Condition for coverage-Environment. 416.44 Section... constructed, equipped, and maintained to protect the health and safety of patients. (a) Standard: Physical... Health Care Centers of the 2000 edition of the Life Safety Code of the National Fire Protection...

42 CFR 416.44 - Condition for coverage-Environment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 3 2012-10-01 2012-10-01 false Condition for coverage-Environment. 416.44 Section... constructed, equipped, and maintained to protect the health and safety of patients. (a) Standard: Physical... Health Care Centers of the 2000 edition of the Life Safety Code of the National Fire Protection...

The RSZ BASIC programming language manual

NASA Technical Reports Server (NTRS)

Stattel, R. J.; Niswander, J. K.; Kochhar, A. K.

1980-01-01

The RSZ BASIC interactive language is described. The RSZ BASIC interpreter is resident in the Telemetry Data Processor, a system dedicated to the processing and displaying of PCM telemetry data. A series of working examples teaches the fundamentals of RSZ BASIC and shows how to construct, edit, and manage storage of programs.

Math: Figure and Object Characteristics. Measurement and Geometry. Grades K-9. Revised Edition.

ERIC Educational Resources Information Center

Instructional Objectives Exchange, Los Angeles, CA.

To help classroom teachers construct mathematics tests, thirty-seven general objectives, corresponding sub-objectives, sample test items, and answers are presented. In general, sub-objectives are arranged in increasing order of difficulty. The objectives were written to comprehensively cover two categories: measurement and geometry. Measurement…

An Assessment of the Dimensionality of SAT-Mathematical.

ERIC Educational Resources Information Center

Lawrence, Ida M.; Dorans, Neil J.

Six editions of Scholastic Aptitude Test-Mathematical (SAT-M) were factor analyzed using confirmatory and exploratory methods. Confirmatory factor analyses (using the LISREL VI program) were conducted on correlation matrices among item parcels--sums of scores on a small subset of items. Item parcels were constructed to yield correlation matrices…

76 FR 32867 - Hazardous Materials: Requirements for Storage of Explosives During Transportation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... from release into the environment. This final rule does not prohibit or promote the development of safe... Association Standard (NFPA) 498--Standard for Safe Havens and Interchange Lots for Vehicles Transporting Explosives (2010 Edition) for the construction and maintenance of safe havens used for unattended storage of...

Life Cycle Cost Analysis Handbook. First Edition.

ERIC Educational Resources Information Center

Alaska State Dept. of Education and Early Development, Juneau.

This handbook presents guidelines on the Life Cycle Cost Analysis (LCCA) of building operations over the life of a building to assist school districts and consultants with evaluating proposed educational facility construction projects. It defines the terminology found in an LCCA, such as initial and future expenses, residual value, real discount…

Education and the Mountain Centres. Second Edition.

ERIC Educational Resources Information Center

Drasdo, Harold

The outdoor education literature reveals little on the values of outdoor education activities. The values of aesthetic education can readily be ascribed to values of an outdoor mountain experience--visual, plastic, musical, kinetic, verbal, and constructive. These values are related through senses, muscles, speech, and thought to form expression.…

Pre-Service Elementary Teachers' Mathematics Content Knowledge: A Predictor of Sixth Graders' Mathematics Performance

ERIC Educational Resources Information Center

Shirvani, Hosin

2015-01-01

This study examined the knowledge of mathematics content of elementary pre-service teachers at a sixth grade level. The researcher administered a mathematics test for sixth graders mandated by the Texas Education Agency to pre-service teachers; the same test was given to sixth graders in Texas. The study found that pre-service teachers performed…

The Sixth Grade: Caught in the Middle.

ERIC Educational Resources Information Center

Lounsbury, John H.

A comparative investigation of the place of the sixth grade in public education used a shadow study technique to address three questions: (1) What is a sixth grader's day in school like? (2) In what ways do programs provided for sixth graders differ, depending on where the grade is located in the school system? (3) How does what is known of the…

Effects of Contributor Experience on the Quality of Health-Related Wikipedia Articles

PubMed Central

Fetahu, Besnik; Kimmerle, Joachim

2018-01-01

Background Consulting the Internet for health-related information is a common and widespread phenomenon, and Wikipedia is arguably one of the most important resources for health-related information. Therefore, it is relevant to identify factors that have an impact on the quality of health-related Wikipedia articles. Objective In our study we have hypothesized a positive effect of contributor experience on the quality of health-related Wikipedia articles. Methods We mined the edit history of all (as of February 2017) 18,805 articles that were listed in the categories on the portal health & fitness in the English language version of Wikipedia. We identified tags within the articles’ edit histories, which indicated potential issues with regard to the respective article’s quality or neutrality. Of all of the sampled articles, 99 (99/18,805, 0.53%) articles had at some point received at least one such tag. In our analysis we only considered those articles with a minimum of 10 edits (10,265 articles in total; 96 tagged articles, 0.94%). Additionally, to test our hypothesis, we constructed contributor profiles, where a profile consisted of all the articles edited by a contributor and the corresponding number of edits contributed. We did not differentiate between rollbacks and edits with novel content. Results Nonparametric Mann-Whitney U-tests indicated a higher number of previously edited articles for editors of the nontagged articles (mean rank tagged 2348.23, mean rank nontagged 5159.29; U=9.25, P<.001). However, we did not find a significant difference for the contributors’ total number of edits (mean rank tagged 4872.85, mean rank nontagged 5135.48; U=0.87, P=.39). Using logistic regression analysis with the respective article’s number of edits and number of editors as covariates, only the number of edited articles yielded a significant effect on the article’s status as tagged versus nontagged (dummy-coded; Nagelkerke R2 for the full model=.17; B [SE B]=-0.001 [0.00]; Wald c2 [1]=19.70; P<.001), whereas we again found no significant effect for the mere number of edits (Nagelkerke R2 for the full model=.15; B [SE B]=0.000 [0.01]; Wald c2 [1]=0.01; P=.94). Conclusions Our findings indicate an effect of contributor experience on the quality of health-related Wikipedia articles. However, only the number of previously edited articles was a predictor of the articles’ quality but not the mere volume of edits. More research is needed to disentangle the different aspects of contributor experience. We have discussed the implications of our findings with respect to ensuring the quality of health-related information in collaborative knowledge-building platforms. PMID:29748161

Ivins examines Destiny with the processing team in the SSPF

NASA Technical Reports Server (NTRS)

1999-01-01

In the Space Station Processing Facility, Marsha Ivins, a mission specialist on the STS-98 crew, inspects the U.S. Laboratory with members of the laboratory's processing team. The laboratory module, considered the centerpiece of the International Space Station (ISS), has been named 'Destiny' in honor of its prominent role in the world's largest science and technology effort. It is planned for launch aboard Space Shuttle Endeavour on the sixth ISS construction flight currently targeted for March 2000. From left to right are Ivins, Jerry Hopkins, Danny Whittington, Melissa Orozco, and Suzanne Fase.

Ivins examines Destiny with the processing team in the SSPF

NASA Technical Reports Server (NTRS)

1999-01-01

In the Space Station Processing Facility, Marsha Ivins (left), a mission specialist on the STS-98 crew, discusses the U.S. Laboratory with members of the laboratory's processing team, (left to right) James Thews, Suzanne Fase, and Danny Whittington. The laboratory module, considered the centerpiece of the International Space Station (ISS), has been named 'Destiny' in honor of its prominent role in the world's largest science and technology effort. It is planned for launch aboard Space Shuttle Endeavour on the sixth ISS construction flight currently targeted for March 2000.

KSC-2012-6383

NASA Image and Video Library

2012-12-04

CAPE CANAVERAL, Fla. – At the Kennedy Space Center Visitor Complex in Florida teams of five students are using kits with identical plastic pieces to build a space station-like truss. Following construction, weights were added to determine its strength and points were awarded based on how much weight their truss would support. Between Nov. 26 and Dec. 7, 2012, about 5,300 sixth-graders in Brevard County, Florida were bused to Kennedy's Visitor Complex for Brevard Space Week, an educational program designed to encourage interest in science, technology, engineering and mathematics STEM careers. Photo credit: NASA/Tim Jacobs

KSC-00padig107

NASA Image and Video Library

2000-11-28

During pre-pack and fit check in the Operations and Checkout Building, STS-97 Mission Specialist Marc Garneau waves after getting his helmet on. Garneau is with the Canadian Space Agency. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00pp1426

NASA Image and Video Library

2000-09-16

During the STS-97 Crew Equipment Interface Test (CEIT), Mission Specialist Carlos Noriega (right) gets hands-on experience with parts of the Orbital Docking System in Endeavour’s payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00pp1758

NASA Image and Video Library

2000-11-27

After arriving at the Shuttle Landing Facility, the STS-97 crew gather to address the media. At the microphone is Pilot Michael Bloomfield. Behind him can be seen Mission Specialists Joseph Tanner and Carlos Noriega. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig055

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Perched atop the Mobile Launcher Platform, Space Shuttle Endeavour approaches the gate to Launch Pad 39B. To the right of the pad is a 290-foot tall water tower. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig055

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Perched atop the Mobile Launcher Platform, Space Shuttle Endeavour approaches the gate to Launch Pad 39B. To the right of the pad is a 290-foot tall water tower. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1426

NASA Image and Video Library

2000-09-16

During the STS-97 Crew Equipment Interface Test (CEIT), Mission Specialist Carlos Noriega (right) gets hands-on experience with parts of the Orbital Docking System in Endeavour’s payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00padig105

NASA Image and Video Library

2000-11-28

STS-97 Mission Specialist Marc Garneau gets help with his boots from suit technician Tommy McDonald during pre-pack and fit check. Garneau is with the Canadian Space Agency. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

Beltzville Lake, Lehigh River Basin, Pohopoco Creek, Pennsylvania, Condition Report. Dam Outlet Works and Spillway

DTIC Science & Technology

1977-07-01

Paragraph Title Page SECTION 1 INTRODUCTION 1-01 Authority and Scope 1 1-02 Construction History 1 ’ 1-03 Inspection and Evaluation 1 SECTION 2 SIXTH...Report No. 6 SECTION 1 INTRODUCTION 1-01. AUTHORITY AND SCOPE. This report has been prepared in accordance with Engineer Regulation 1110-2-100 entitled...DATA ___________.. ... ..._____1975-1976 PLATE 4 t iZ .. .4 7 ....T . . jAUG . - SEPT - OCT’ NOV DE( -AN . FED MAR i’- o~y d!1 I -4 WEI IIi OZ [ 011. u

STS-97 Mission Specialist Tanner during pre-pack and fit check

NASA Technical Reports Server (NTRS)

2000-01-01

STS-97 Mission Specialist Joseph Tanner gets help with his boots from suit technician Erin Canlon during check pre-pack and fit check. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST.

STS-97 Mission Specialist Noriega during pre-pack and fit check

NASA Technical Reports Server (NTRS)

2000-01-01

STS-97 Mission Specialist Carlos Noriega gets help with his boots from suit technician Shelly Grick-Agrella during pre-pack and fit check. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST.

The development of a computer assisted instruction and assessment system in pharmacology.

PubMed

Madsen, B W; Bell, R C

1977-01-01

We describe the construction of a computer based system for instruction and assessment in pharmacology, utilizing a large bank of multiple choice questions. Items were collected from many sources, edited and coded for student suitability, topic, taxonomy and difficulty and text references. Students reserve a time during the day, specify the type of test desired and questions are presented randomly from the subset satisfying their criteria. Answers are scored after each question and a summary given at the end of every test; details on item performance are recorded automatically. The biggest hurdle in implementation was the assembly, review, classification and editing of items, while the programming was relatively straight-forward. A number of modifications had to be made to the initial plans and changes will undoubtedly continue with further experience. When fully operational the system will possess a number of advantages including: elimination of test preparation, editing and marking; facilitated item review opportunities; increased objectivity, feedback, flexibility and descreased anxiety in students.

[Chromosomal large fragment deletion induced by CRISPR/Cas9 gene editing system].

PubMed

Cheng, L H; Liu, Y; Niu, T

2017-05-14

Objective: Using CRISPR-Cas9 gene editing technology to achieve a number of genes co-deletion on the same chromosome. Methods: CRISPR-Cas9 lentiviral plasmid that could induce deletion of Aloxe3-Alox12b-Alox8 cluster genes located on mouse 11B3 chromosome was constructed via molecular clone. HEK293T cells were transfected to package lentivirus of CRISPR or Cas9 cDNA, then mouse NIH3T3 cells were infected by lentivirus and genomic DNA of these cells was extracted. The deleted fragment was amplified by PCR, TA clone, Sanger sequencing and other techniques were used to confirm the deletion of Aloxe3-Alox12b-Alox8 cluster genes. Results: The CRISPR-Cas9 lentiviral plasmid, which could induce deletion of Aloxe3-Alox12b-Alox8 cluster genes, was successfully constructed. Deletion of target chromosome fragment (Aloxe3-Alox12b-Alox8 cluster genes) was verified by PCR. The deletion of Aloxe3-Alox12b-Alox8 cluster genes was affirmed by TA clone, Sanger sequencing, and the breakpoint junctions of the CRISPR-Cas9 system mediate cutting events were accurately recombined, insertion mutation did not occur between two cleavage sites at all. Conclusion: Large fragment deletion of Aloxe3-Alox12b-Alox8 cluster genes located on mouse chromosome 11B3 was successfully induced by CRISPR-Cas9 gene editing system.

A Quantitative Study on the Correlation between Grade Span Configuration of Sixth Grade Students in Private Florida Schools and Academic Achievement on Standardized Achievement Scores

ERIC Educational Resources Information Center

Rantin, Deborah

2017-01-01

The applied dissertation was designed to investigate the three models of grade span configurations of sixth grade and the effects grade span configuration has on results of the standardized achievement scores of sixth grade students in private, Florida schools. Studies that have been conducted on sixth grade students and grade span configuration…

On Improving CRISPR for Editing Plant Genes: Ribozyme-Mediated Guide RNA Production and Fluorescence-Based Technology for Isolating Transgene-Free Mutants Generated by CRISPR.

PubMed

He, Yubing; Wang, Rongchen; Dai, Xinhua; Zhao, Yunde

2017-01-01

CRISPR/Cas9-mediated genome editing technology has been used to successfully edit numerous genes in various organisms including plants. There are still two major challenges in using CRISPR/Cas9 technology for gene editing in plants. First, there are very limited choices of promoters that are suitable for in vivo production of single-guide RNAs (sgRNAs), which is complementary to the target sequence and which guides Cas9 to generate double-strand breaks at the target site. It is especially difficult to produce sgRNA molecules with temporal and spatial precision. Second, there is a lack of efficient methods for identifying plants that (1) contain heritable and stable mutations generated by CRISPR/Cas9, and (2) no longer harbor the CRISPR/Cas9 construct and other transgenes. In this chapter, we describe the development of a ribozyme-based strategy that enables the production of sgRNA molecules from any chosen promoter. More importantly, the ribozyme-based technology makes it feasible to produce sgRNAs with temporal and spatial precision, greatly expanding the scope and applications of CRISPR/Cas9 technology. We also developed a fluorescence-based technology that allows us to efficiently and reliably isolate Cas9-free stable Arabidopsis mutants. Thus, we provide effective protocols to overcome two important obstacles in using CRISPR/Cas9 for editing genes in plants. © 2017 Elsevier Inc. All rights reserved.

Parenting Styles of Military and Civilian Families: The Impact of Deployment, Mood, and Marital Satisfaction

DTIC Science & Technology

2012-09-12

Psychology, 15 (4), 407-408. Freud , S. (1960). The psychopathology of everyday life. The standard edition of the Complete works of Sigmund Freud (Vol. 6...At about 5         the same time, Freud (1960), using a psychodynamic approach, focused on the construct of nurturance (Darling

Successful School Board Meetings. A Special Edition for New Jersey School Boards.

ERIC Educational Resources Information Center

Anderson, Stuart A.

This handbook was written to help school boards conduct routine business meetings more efficiently, and thereby improve their ability to reach constructive decisions and solve problems. After a brief introduction, the first chapter focuses on organizing the new school board, electing officers, adopting policies, and appointing committees. The…

Introduction to Insulation. Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Associated General Contractors of America, Washington, DC.

This module on introductory insulation is one of a series of modules designed to teach basic skills necessary for entry-level employment in this field. The instructor's guide contains three instructional units that cover the following topics: (1) insulation materials; (2) insulation tools; and (3) insulation layout and basic skills. Each…

Inventory and Evaluation of Cultural Resources, Bolsa Chica Mesa and Huntington Beach Mesa, Orange County, California

DTIC Science & Technology

1989-09-30

Excelentisimo Conde de Monterey, Virrey Que Era dela Nueva Espana. In Monarchia Indiana, edited by J. de Torquemada, pp. 693-725. Madrid. 101 102 Baumhoff, M...biological bacterias , this includes the destruction of canyons, hills, mountains and the flora and fauna in these areas. Road construction, real

College and University Budgeting: An Introduction for Faculty and Academic Administrators. Second Edition.

ERIC Educational Resources Information Center

Meisinger, Richard J., Jr.

This book is designed to help college/university faculty and academic administrators become more constructive and knowledgeable participants in the budgetary process. Chapter 1 introduces budgets and the budgetary process, with an explanation of the importance of budgeting in policy making, Chapter 2 discusses economic and political contexts of…

Challenges in Social Communication in Asperger Syndrome and High-Functioning Autism

ERIC Educational Resources Information Center

Rubin, Emily; Lennon, Laurie

2004-01-01

Despite the inclusion of Asperger syndrome in the Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition (DSM-IV) American Psychiatric Association [APA], 1994) 10 years ago, there is ongoing debate regarding its validity as a diagnostic construct, particularly relative to the diagnosis of autistic disorder when it is not accompanied…

Bibliography of Assessment Alternatives: Mathematics. January 1998 Edition. Innovative Assessment.

ERIC Educational Resources Information Center

Northwest Regional Educational Lab., Portland, OR.

Mathematics alternative assessment continues to be a hot topic with much activity on development, standards setting, and relation to reform. This document defines alternative assessment as any assessment in which students construct a response to a question rather than choosing a response from a list. This annotated bibliography contains the…

Life Behind the Wall: Palestinian Students Online

ERIC Educational Resources Information Center

Hart, Doug

2007-01-01

In this article, the author discusses an online youth magazine that his Palestinian students developed. In April of 2006, they launched the inaugural edition of their teen e-zine, "Behind the Wall." With the help of his brother-in-law, students, along with a computer programmer, the "Behind the Wall" website was constructed.…

Literacy through the Book Arts.

ERIC Educational Resources Information Center

Johnson, Paul

This book, a guide for adults to help children create their own original and creative books, demonstrates how constructing (writing and editing) their own books can be an engaging and highly educational experience for children. The book uses simple, easy-to-follow instructions to demonstrate how scores of different book forms can be made from a…

Same Constructs, Different Results: Examining the Consistency of Two Behavior-Rating Scales with Referred Preschoolers

ERIC Educational Resources Information Center

Myers, Carl L.; Bour, Jennifer L.; Sidebottom, Kristina J.; Murphy, Sara B.; Hakman, Melissa

2010-01-01

Broad-band or multidimensional behavior-rating scales are common tools for evaluating children. Two popular behavior-rating scales, the Behavior Assessment System for Children, Second Edition (BASC-2; Reynolds & Kamphaus, 2004) and the Child Behavior Checklist (CBCL; Achenbach & Rescorla, 2000), have undergone downward extensions so that…

Introduction to Welding. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This document contains the materials necessary to teach four instructional units on welding that are designed to prepare learners for entry-level employment. The following instructional units are presented: (1) welding materials; (2) welding tools; (3) welding layout and basic skills; and (4) oxyacetylene cutting. The document begins with a copy…

49 CFR 393.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... waste, recycling, construction/demolition and scrap industries, which is used in conjunction with... requirements of § 571.224 in effect on the date of manufacture, or a subsequent edition. (2) A motor vehicle... surface requirements of § 571.224 (paragraphs S5.1.1 through S5.1.3), in effect on the date of manufacture...

49 CFR 393.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... waste, recycling, construction/demolition and scrap industries, which is used in conjunction with... requirements of § 571.224 in effect on the date of manufacture, or a subsequent edition. (2) A motor vehicle... surface requirements of § 571.224 (paragraphs S5.1.1 through S5.1.3), in effect on the date of manufacture...

49 CFR 393.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... waste, recycling, construction/demolition and scrap industries, which is used in conjunction with... requirements of § 571.224 in effect on the date of manufacture, or a subsequent edition. (2) A motor vehicle... surface requirements of § 571.224 (paragraphs S5.1.1 through S5.1.3), in effect on the date of manufacture...

Control Robotics Programming Technology. Technology Learning Activity. Teacher Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This Technology Learning Activity (TLA) for control robotics programming technology in grades 6-10 is designed to teach students to construct and program computer-controlled devices using a LEGO DACTA set and computer interface and to help them understand how control technology and robotics affect them and their lifestyle. The suggested time for…

Disaster Response and Planning for Libraries, Third Edition

ERIC Educational Resources Information Center

Kahn, Miriam B.

2012-01-01

Fire, water, mold, construction problems, power-outages--mishaps like these can not only bring library services to a grinding halt, but can also destroy collections and even endanger employees. Preparing for the unexpected is the foundation of a library's best response. Expert Kahn comes to the rescue with this timely update of the best…

Construct Validity of the WISC-IV[superscript UK] with a Large Referred Irish Sample

ERIC Educational Resources Information Center

Watkins, Marley W.; Canivez, Gary L.; James, Trevor; James, Kate; Good, Rebecca

2013-01-01

Irish educational psychologists frequently use the Wechsler Intelligence Scale for Children-Fourth U.K. Edition (WISC-IV[superscript UK]) in clinical assessments of children with learning difficulties. Unfortunately, reliability and validity studies of the WISC-IV[superscript UK] have not yet been reported. This study examined the construct…

Introduction to Concrete Reinforcing. Instructor Edition. Introduction to Construction Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This module on concrete reinforcing is one of a series of modules designed to teach basic skills necessary for entry-level employment in this field. This module contains three instructional units that cover the following topics: (1) concrete reinforcing materials; (2) concrete reinforcing tools; and (3) concrete reinforcing basic skills. Each…

The Trisection Problem.

ERIC Educational Resources Information Center

Yates, Robert C.

This book, photographically reproduced from its original 1942 edition, is an extended essay on one of the three problems of the ancients. The first chapter reduces the problem of trisecting an angle to the solution of a cubic equation, shows that straightedge and compasses constructions can only give lengths of a certain form, and then proves that…

Computer-Aided Authoring System (AUTHOR) User's Guide. Volume I. Final Report.

ERIC Educational Resources Information Center

Guitard, Charles R.

This user's guide for AUTHOR, an automatic authoring system which produces programmed texts for teaching symbol recognition, provides detailed instructions to help the user construct and enter the information needed to create the programmed text, run the AUTHOR program, and edit the automatically composed paper. Major sections describe steps in…

Thermodynamic framework for information in nanoscale systems with memory

NASA Astrophysics Data System (ADS)

Arias-Gonzalez, J. Ricardo

2017-11-01

Information is represented by linear strings of symbols with memory that carry errors as a result of their stochastic nature. Proofreading and edition are assumed to improve certainty although such processes may not be effective. Here, we develop a thermodynamic theory for material chains made up of nanoscopic subunits with symbolic meaning in the presence of memory. This framework is based on the characterization of single sequences of symbols constructed under a protocol and is used to derive the behavior of ensembles of sequences similarly constructed. We then analyze the role of proofreading and edition in the presence of memory finding conditions to make revision an effective process, namely, to decrease the entropy of the chain. Finally, we apply our formalism to DNA replication and RNA transcription finding that Watson and Crick hybridization energies with which nucleotides are branched to the template strand during the copying process are optimal to regulate the fidelity in proofreading. These results are important in applications of information theory to a variety of solid-state physical systems and other biomolecular processes.

Independent examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): what does the WAIS-IV measure?

PubMed

Benson, Nicholas; Hulac, David M; Kranzler, John H

2010-03-01

Published empirical evidence for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs measured and (b) determine whether the same constructs are measured across ages. Results suggest that a Cattell-Horn-Carroll (CHC)-inspired structure provides a better description of test performance than the published scoring structure does. Broad CHC abilities measured by the WAIS-IV include crystallized ability (Gc), fluid reasoning (Gf), visual processing (Gv), short-term memory (Gsm), and processing speed (Gs), although some of these abilities are measured more comprehensively than are others. Additionally, the WAIS-IV provides a measure of quantitative reasoning (QR). Results also suggest a lack of cross-age invariance resulting from age-related differences in factor loadings. Formulas for calculating CHC indexes and suggestions for interpretation are provided. PsycINFO Database Record (c) 2010 APA, all rights reserved.

Thermodynamic framework for information in nanoscale systems with memory.

PubMed

Arias-Gonzalez, J Ricardo

2017-11-28

Information is represented by linear strings of symbols with memory that carry errors as a result of their stochastic nature. Proofreading and edition are assumed to improve certainty although such processes may not be effective. Here, we develop a thermodynamic theory for material chains made up of nanoscopic subunits with symbolic meaning in the presence of memory. This framework is based on the characterization of single sequences of symbols constructed under a protocol and is used to derive the behavior of ensembles of sequences similarly constructed. We then analyze the role of proofreading and edition in the presence of memory finding conditions to make revision an effective process, namely, to decrease the entropy of the chain. Finally, we apply our formalism to DNA replication and RNA transcription finding that Watson and Crick hybridization energies with which nucleotides are branched to the template strand during the copying process are optimal to regulate the fidelity in proofreading. These results are important in applications of information theory to a variety of solid-state physical systems and other biomolecular processes.

Genome editing for human gene therapy.

PubMed

Meissner, Torsten B; Mandal, Pankaj K; Ferreira, Leonardo M R; Rossi, Derrick J; Cowan, Chad A

2014-01-01

The rapid advancement of genome-editing techniques holds much promise for the field of human gene therapy. From bacteria to model organisms and human cells, genome editing tools such as zinc-finger nucleases (ZNFs), TALENs, and CRISPR/Cas9 have been successfully used to manipulate the respective genomes with unprecedented precision. With regard to human gene therapy, it is of great interest to test the feasibility of genome editing in primary human hematopoietic cells that could potentially be used to treat a variety of human genetic disorders such as hemoglobinopathies, primary immunodeficiencies, and cancer. In this chapter, we explore the use of the CRISPR/Cas9 system for the efficient ablation of genes in two clinically relevant primary human cell types, CD4+ T cells and CD34+ hematopoietic stem and progenitor cells. By using two guide RNAs directed at a single locus, we achieve highly efficient and predictable deletions that ablate gene function. The use of a Cas9-2A-GFP fusion protein allows FACS-based enrichment of the transfected cells. The ease of designing, constructing, and testing guide RNAs makes this dual guide strategy an attractive approach for the efficient deletion of clinically relevant genes in primary human hematopoietic stem and effector cells and enables the use of CRISPR/Cas9 for gene therapy.

CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973.

PubMed

Wendt, Kristen E; Ungerer, Justin; Cobb, Ryan E; Zhao, Huimin; Pakrasi, Himadri B

2016-06-23

As autotrophic prokaryotes, cyanobacteria are ideal chassis organisms for sustainable production of various useful compounds. The newly characterized cyanobacterium Synechococcus elongatus UTEX 2973 is a promising candidate for serving as a microbial cell factory because of its unusually rapid growth rate. Here, we seek to develop a genetic toolkit that enables extensive genomic engineering of Synechococcus 2973 by implementing a CRISPR/Cas9 editing system. We targeted the nblA gene because of its important role in biological response to nitrogen deprivation conditions. First, we determined that the Streptococcus pyogenes Cas9 enzyme is toxic in cyanobacteria, and conjugational transfer of stable, replicating constructs containing the cas9 gene resulted in lethality. However, after switching to a vector that permitted transient expression of the cas9 gene, we achieved markerless editing in 100 % of cyanobacterial exconjugants after the first patch. Moreover, we could readily cure the organisms of antibiotic resistance, resulting in a markerless deletion strain. High expression levels of the Cas9 protein in Synechococcus 2973 appear to be toxic and result in cell death. However, introduction of a CRISPR/Cas9 genome editing system on a plasmid backbone that leads to transient cas9 expression allowed for efficient markerless genome editing in a wild type genetic background.

Non-coding RNA may be associated with cytoplasmic male sterility in Silene vulgaris

PubMed Central

Stone, James D.; Koloušková, Pavla; Sloan, Daniel B.

2017-01-01

Abstract Cytoplasmic male sterility (CMS) is a widespread phenomenon in flowering plants caused by mitochondrial (mt) genes. CMS genes typically encode novel proteins that interfere with mt functions and can be silenced by nuclear fertility-restorer genes. Although the molecular basis of CMS is well established in a number of crop systems, our understanding of it in natural populations is far more limited. To identify CMS genes in a gynodioecious plant, Silene vulgaris, we constructed mt transcriptomes and compared transcript levels and RNA editing patterns in floral bud tissue from female and hermaphrodite full siblings. The transcriptomes from female and hermaphrodite individuals were very similar overall with respect to variation in levels of transcript abundance across the genome, the extent of RNA editing, and the order in which RNA editing and intron splicing events occurred. We found only a single genomic region that was highly overexpressed and differentially edited in females relative to hermaphrodites. This region is not located near any other transcribed elements and lacks an open-reading frame (ORF) of even moderate size. To our knowledge, this transcript would represent the first non-coding mt RNA associated with CMS in plants and is, therefore, an important target for future functional validation studies. PMID:28369520

LUMIS: Land Use Management and Information Systems; coordinate oriented program documentation

NASA Technical Reports Server (NTRS)

1976-01-01

An integrated geographic information system to assist program managers and planning groups in metropolitan regions is presented. The series of computer software programs and procedures involved in data base construction uses the census DIME file and point-in-polygon architectures. The system is described in two parts: (1) instructions to operators with regard to digitizing and editing procedures, and (2) application of data base construction algorithms to achieve map registration, assure the topological integrity of polygon files, and tabulate land use acreages within administrative districts.

Ride With Astronauts In Flyby Salute to Marshall Center Test Stand Construction Teams

NASA Image and Video Library

2016-09-27

NASA astronaut Don Pettit captured this video from the cockpit with Victor Glover as they and fellow astronauts Barry "Butch” Wilmore and Stephanie Wilson banked low over Marshall Space Flight Center at Huntsville, Alabama, saluting to teams finishing construction of Test Stand 4697. In the short video edited by Pettit, viewers fly along from the astronauts' takeoff in two NASA T-38 jets from Ellington Field Joint Reserve Base in Houston to their landing at Huntsville International Airport for meetings at Marshall. (NASA/Don Pettit)

Effects of Contributor Experience on the Quality of Health-Related Wikipedia Articles.

PubMed

Holtz, Peter; Fetahu, Besnik; Kimmerle, Joachim

2018-05-10

Consulting the Internet for health-related information is a common and widespread phenomenon, and Wikipedia is arguably one of the most important resources for health-related information. Therefore, it is relevant to identify factors that have an impact on the quality of health-related Wikipedia articles. In our study we have hypothesized a positive effect of contributor experience on the quality of health-related Wikipedia articles. We mined the edit history of all (as of February 2017) 18,805 articles that were listed in the categories on the portal health & fitness in the English language version of Wikipedia. We identified tags within the articles' edit histories, which indicated potential issues with regard to the respective article's quality or neutrality. Of all of the sampled articles, 99 (99/18,805, 0.53%) articles had at some point received at least one such tag. In our analysis we only considered those articles with a minimum of 10 edits (10,265 articles in total; 96 tagged articles, 0.94%). Additionally, to test our hypothesis, we constructed contributor profiles, where a profile consisted of all the articles edited by a contributor and the corresponding number of edits contributed. We did not differentiate between rollbacks and edits with novel content. Nonparametric Mann-Whitney U-tests indicated a higher number of previously edited articles for editors of the nontagged articles (mean rank tagged 2348.23, mean rank nontagged 5159.29; U=9.25, P<.001). However, we did not find a significant difference for the contributors' total number of edits (mean rank tagged 4872.85, mean rank nontagged 5135.48; U=0.87, P=.39). Using logistic regression analysis with the respective article's number of edits and number of editors as covariates, only the number of edited articles yielded a significant effect on the article's status as tagged versus nontagged (dummy-coded; Nagelkerke R 2 for the full model=.17; B [SE B]=-0.001 [0.00]; Wald c 2 [1]=19.70; P<.001), whereas we again found no significant effect for the mere number of edits (Nagelkerke R 2 for the full model=.15; B [SE B]=0.000 [0.01]; Wald c 2 [1]=0.01; P=.94). Our findings indicate an effect of contributor experience on the quality of health-related Wikipedia articles. However, only the number of previously edited articles was a predictor of the articles' quality but not the mere volume of edits. More research is needed to disentangle the different aspects of contributor experience. We have discussed the implications of our findings with respect to ensuring the quality of health-related information in collaborative knowledge-building platforms. ©Peter Holtz, Besnik Fetahu, Joachim Kimmerle. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 10.05.2018.

Fatty acid profile comparisons in human milk sampled from the same mothers at the sixth week and the sixth month of lactation.

PubMed

Szabó, Eva; Boehm, Günther; Beermann, Christopher; Weyermann, Maria; Brenner, Hermann; Rothenbacher, Dietrich; Decsi, Tamás

2010-03-01

To compare fatty acid composition of human milk at 2 different stages of lactation and investigate the relation between trans isomeric and long-chain polyunsaturated fatty acids (LCPUFAs) in human milk at the sixth month of lactation. We investigated human milk samples obtained at the sixth week and sixth month of lactation from 462 mothers who participated in a large birth cohort study. Fatty acid composition of human milk lipids was determined by high-resolution capillary gas-liquid chromatography. Fat contents of human milk increased significantly between the sixth week and sixth month of lactation (1.63 [2.06] and 3.19 [3.14], g/100 mL; median [interquartile range], P < 0.001). Percentage contributions to human milk fatty acid composition of nearly all polyunsaturated fatty acids also increased significantly (linoleic acid: 10.09 [4.41] and 11.01 [4.53], arachidonic acid: 0.46 [0.32] and 0.48 [0.23], alpha-linolenic acid: 0.69 [0.42] and 0.75 [0.41], and docosahexaenoic acid: 0.17 [0.23] and 0.23 [0.15], % wt/wt, P < 0.001). Values of the 18-carbon trans octadecenoic acid (C18:1n-7/9t) significantly inversely correlated to linoleic acid (r = -0.24, P < 0.001), alpha-linolenic acid (r = -0.19, P < 0.001), and arachidonic acid (r = -0.43, P < 0.001). In contrast, we found no correlation between the 16-carbon trans hexadecenoic acid (C16:1n-7t) and the same LCPUFAs. Data obtained in the present study indicate increasing fat contents with stable or increasing percentage contribution of LCPUFAs in human milk samples between the sixth week and at the sixth month of lactation, and the availability of 18-carbon trans isomeric fatty acids is inversely associated to the availability of several LCPUFAs in human milk at the sixth month of lactation.

KSC00spn002

NASA Image and Video Library

2001-07-26

KENNEDY SPACE CENTER, FLA. -- Day in the Life page 2. Preparing the pad. Workers maintain Pad A at Kennedy Space Center’s Launch Complex 39. Robert Lust of IVEY Construction pauses on his way to install a safety handrail. This photograph was taken for a special color edition of Spaceport News designed to portray in photographs a single day at KSC, July 26, 2000. The special edition, published Aug. 25, 2000, was created to give readers a look at KSC’s diverse workforce and the critical roles workers play in the nation’s space program. Spaceport News is an official publication of the Kennedy Space Center and is published on alternate Fridays by the Public Affairs Office in the interest of KSC civil service and contractor employees

78 FR 67168 - Sixth Annual Sentinel Initiative; Public Workshop

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

...] Sixth Annual Sentinel Initiative; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION... workshop entitled ``Sixth Annual Sentinel Initiative.'' Convened by the Engelberg Center for Health Care... product surveillance. Topics will include an overview of the status of FDA's Sentinel Initiative and...

Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy.

PubMed

Akbari, Mohammadreza; Shomali, Setareh; Mirmohammadsadeghi, Arash; Fard, Masoud Aghsaei

2018-05-01

Superior rectus transposition (SRT) with medial rectus recession has been used for the treatment of sixth nerve palsy and esotropic Duane retraction syndrome (DRS). The purpose of this study was to compare the results of augmented SRT (with scleral fixation) without medial rectus recession in DRS and sixth nerve palsy. Patients with unilateral esotropic DRS (DRS group) and sixth nerve palsy were included in this prospective, comparative study and underwent SRT. Preoperative forced duction testing was negative or slightly positive in both groups. Prospective measurements were compared between the two groups. There were 11 patients in the DRS group and 11 patients in the sixth nerve palsy group. The mean preoperative esotropia decreased from 20.9 ± 6.0 prism diopter (PD) at far to 13.2 ± 5.8 PD in the DRS group (P = 0.003). The same measurement improved from 28.0 ± 8.5 PD to 8.4 ± 7.3 PD in the sixth nerve palsy group (P = 0.003). In the sixth nerve palsy group, the improvement in primary gaze esotropia and abnormal head posture was more than the DRS group (Both P < 0.001).The average dose effect for SRT was 7.8 ± 2.2 PD in the DRS group and 19.2 ± 4.6 PD in the sixth nerve palsy group. Although objective intorsion was significantly induced after SRT, subjective torsion was not significant after surgery in both groups. SRT appears to be more effective in improving primary gaze deviation and head posture in sixth nerve palsy compared with DRS. Subjective torsional and vertical diplopia were rare in both groups.

Writing Assignments in Disguise: Lessons Learned Using Video Projects in the Classroom

NASA Astrophysics Data System (ADS)

Wade, P.; Courtney, A.

2012-12-01

This study describes the instructional approach of using student-created video documentaries as projects in an undergraduate non-science majors' Energy Perspectives science course. Four years of teaching this course provided many reflective teaching moments from which we have enhanced our instructional approach to teaching students how to construct a quality Ken Burn's style science video. Fundamental to a good video documentary is the story told via a narrative which involves significant writing, editing and rewriting. Many students primarily associate a video documentary with visual imagery and do not realize the importance of writing in the production of the video. Required components of the student-created video include: 1) select a topic, 2) conduct research, 3) write an outline, 4) write a narrative, 5) construct a project storyboard, 6) shoot or acquire video and photos (from legal sources), 7) record the narrative, 8) construct the video documentary, 9) edit and 10) finalize the project. Two knowledge survey instruments (administered pre- and post) were used for assessment purposes. One survey focused on the skills necessary to research and produce video documentaries and the second survey assessed students' content knowledge acquired from each documentary. This talk will focus on the components necessary for video documentaries and the instructional lessons learned over the years. Additionally, results from both surveys and student reflections of the video project will be shared.

Prolonged grief: where to after Diagnostic and Statistical Manual of Mental Disorders, 5th Edition?

PubMed

Bryant, Richard A

2014-01-01

Although there is much evidence for the construct of prolonged grief, there was much controversy over the proposal to introduce a prolonged grief diagnosis into Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), and it was finally rejected as a diagnosis in DSM-5. This review outlines the evidence for and against the diagnosis, and highlights the implications of the DSM-5 decision. Convergent evidence indicates that prolonged grief characterized by persistently severe yearning for the deceased is a distinct construct from bereavement-related depression and anxiety, is associated with marked functional impairment, is responsive to targeted treatments for prolonged grief, and has been validated across different cultures, age groups, and types of bereavement. Although DSM-5 has rejected the construct as a formal diagnosis, evidence continues to emerge on related mechanisms, including maladaptive appraisals, memory and attentional processes, immunological and arousal responses, and neural circuitry. It is most likely that the International Classification of Diseases (ICD-11) will introduce a diagnosis to recognize prolonged grief, even though DSM-5 has decided against this option. It is probable that the DSM-5 decision may result in more prolonged grief patients being incorrectly diagnosed with depression after bereavement and possibly incorrectly treated. The DSM-5 decision is unlikely to impact on future research agendas.

Can we improve the clinical assessment of working memory? An evaluation of the Wechsler Adult Intelligence Scale-Third Edition using a working memory criterion construct.

PubMed

Hill, B D; Elliott, Emily M; Shelton, Jill T; Pella, Russell D; O'Jile, Judith R; Gouvier, W Drew

2010-03-01

Working memory is the cognitive ability to hold a discrete amount of information in mind in an accessible state for utilization in mental tasks. This cognitive ability is impaired in many clinical populations typically assessed by clinical neuropsychologists. Recently, there have been a number of theoretical shifts in the way that working memory is conceptualized and assessed in the experimental literature. This study sought to determine to what extent the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) Working Memory Index (WMI) measures the construct studied in the cognitive working memory literature, whether an improved WMI could be derived from the subtests that comprise the WAIS-III, and what percentage of variance in individual WAIS-III subtests is explained by working memory. It was hypothesized that subtests beyond those currently used to form the WAIS-III WMI would be able to account for a greater percentage of variance in a working memory criterion construct than the current WMI. Multiple regression analyses (n = 180) revealed that the best predictor model of subtests for assessing working memory was composed of the Digit Span, Letter-Number Sequencing, Matrix Reasoning, and Vocabulary. The Arithmetic subtest was not a significant contributor to the model. These results are discussed in the context of how they relate to Unsworth and Engle's (2006, 2007) new conceptualization of working memory mechanisms.

Preventing Youths' Use of Inhalants and Other Harmful Legal Products in Frontier Alaskan Communities: A Randomized Trial

PubMed Central

Shamblen, Stephen R.; Ogilvie, Kristen A.; Collins, David; Saylor, Brian

2013-01-01

This study tests for the efficacy of a school-based drug prevention curriculum (Think Smart) that was designed to reduce use of Harmful Legal Products (HLPs, such as inhalants and over-the-counter drugs), alcohol, tobacco, and other drugs among fifth- and sixth-grade students in frontier Alaska. The curriculum consisted of 12 core sessions and 3 booster sessions administered 2 to 3 months later, and was an adaptation of the Schinke life skills training curriculum for Native Americans. Fourteen communities, which represented a mixture of Caucasian and Alaska Native populations in various regions of the state, were randomly assigned to intervention or control conditions. Single items measuring 30-day substance use and multi-item scales measuring the mediators under study were taken from prior studies. Scales for the mediators demonstrated satisfactory construct validity and internal reliability. A pre-intervention survey was administered in classrooms in each school in the fall semester of the fifth and sixth grades prior to implementing the Think Smart curriculum, and again in the spring semester immediately following the booster session. A follow-up survey was administered 6 months later in the fall semester of the sixth and seventh grades. A multi-level analysis found that the Think Smart curriculum produced a decrease (medium size effect) in the proportion of students who used HLPs over a 30-day period at the 6 month follow-up assessment. There were no effects on other drug use. Further, the direct effect of HLPs use was not mediated by the measured risk and protective factors that have been promoted in the prevention field. Alternative explanations and implications of these results are discussed. PMID:19440837

Teaching Language in Context. Second Edition

ERIC Educational Resources Information Center

Derewianka, Beverly; Jones, Pauline

2016-01-01

Language is at the heart of the learning process. We learn through language. Our knowledge about the world is constructed in language-the worlds of home and the community, the worlds of school subjects, the worlds of literature, the worlds of the workplace, and so on. It is through language that we interact with others and build our identities.…

Validity of the Mayer-Salovey-Caruso Emotional Intelligence Test: Youth Version-Research Edition

ERIC Educational Resources Information Center

Peters, Christine; Kranzler, John H.; Rossen, Eric

2009-01-01

This study examines the criterion-related validity evidence of scores on the Mayer-Salovey-Caruso Emotional Intelligence Test: Youth Version-Research Version. The authors also investigate the relationship between scores on the MSCEIT-YV and chronological age. Results provide initial support for the construct validity of the MSCEIT-YV but also…

A Framework for Teaching Basic Economic Concepts with Scope and Sequence Guidelines K-12.

ERIC Educational Resources Information Center

Saunders, Phillip, Ed.; Gilliard, June V., Ed.

This publication is an updated, edited merger of two earlier National Council on Economic Education documents: "A Framework for Teaching the Basic Concepts" and "Economics: What and When." The combined publication is designed to aid those who construct curricula or who provide economics instruction in U.S. schools. The book…

WAIS-IV and Clinical Validation of the Four- and Five-Factor Interpretative Approaches

ERIC Educational Resources Information Center

Weiss, Lawrence G.; Keith, Timothy Z.; Zhu, Jianjun; Chen, Hsinyi

2013-01-01

The fourth edition of the Wechsler Adult Intelligence Scale (WAIS-IV) is a revised and substantially updated version of its predecessor. The purposes of this research were to determine the constructs measured by the test and the consistency of measurement across large normative and clinical samples. Competing higher order WAIS-IV four- and…

Concurrent and Construct Validity of Oral Language Measures with School-Age Children with Specific Language Impairment

ERIC Educational Resources Information Center

Hoffman, LaVae M.; Loeb, Diane Frome; Brandel, Jayne; Gillam, Ronald B.

2011-01-01

Purpose: This study investigated the psychometric properties of 2 oral language measures that are commonly used for diagnostic purposes with school-age children who have language impairments. Method: Two hundred sixteen children with specific language impairment were assessed with the Test of Language Development--Primary, Third Edition (TOLD-P:3;…

Act Your Age! A Cultural Construction of Adolescence. Critical Social Thought. Second Edition

ERIC Educational Resources Information Center

Lesko, Nancy

2012-01-01

Are our current ways of talking about "the problem of adolescence" really that different than those of past generations? For the past decade, Act Your Age! has provided a provocative and now classic analysis of the accepted ways of viewing teens. By employing a groundbreaking "history of the present" methodology that resists traditional…

Math: Data Relationships. Graphs, Ratios and Proportions, Statistics and Probability. Grades K-9. Revised Edition.

ERIC Educational Resources Information Center

Instructional Objectives Exchange, Los Angeles, CA.

To help classroom teachers in grades K-9 construct mathematics tests, fifteen general objectives, corresponding sub-objectives, sample test items, and answers are presented. In general, sub-objectives are arranged in increasing order of difficulty. The objectives were written to comprehensively cover three categories. The first, graphs, covers the…

Guidelines for the Establishment and Development of Monolingual Thesauri. Second Revised Edition.

ERIC Educational Resources Information Center

Austin, Derek; Dale, Peter

Intended to facilitate the preparation of thesauri for the indexing of documents in any subject field, this report presents a set of rules pertaining to the complex issues and questions involved in indexing vocabulary development and construction. After a brief discussion of the nature, functions, and components of indexing vocabularies, a set of…

Automobile Ignition System Minicourse, Career Oriented Pre-Technical Physics. Preliminary Edition.

ERIC Educational Resources Information Center

Bullock, Bob; And Others

This minicourse was prepared for use with secondary physics students in the Dallas Independent School District and is one option in a physics program which provides for the selection of topics on the basis of student career needs and interests. This minicourse was aimed at providing the student with a basic understanding of the construction and…

Access to Vocational Training in Three Sectors of the European Economy. Comparative Analysis. 2nd Edition. CEDEFOP Panorama.

ERIC Educational Resources Information Center

Lassibille, Gerard; Paul, Jean-Jacques

This report presents findings of a study of the theoretical and practical methods of access to continuing vocational training. It summarizes six reports that compare the following: the construction sector in Spain, France, Italy, and Luxembourg; the banking, insurance, commerce, and administration sectors in Germany, Ireland, the Netherlands, and…

Higher-Order Factor Structure of the Differential Ability Scales-II: Consistency across Ages 4 to 17

ERIC Educational Resources Information Center

Keith, Timothy Z.; Low, Justin A.; Reynolds, Matthew R.; Patel, Puja G.; Ridley, Kristen P.

2010-01-01

The recently published second edition of the Differential Abilities Scale (DAS-II) is designed to measure multiple broad and general abilities from Cattell-Horn-Carroll (CHC) theory. Although the technical manual presents information supporting the test's structure, additional research is needed to determine the constructs measured by the test and…

The Role of a Language Scale for Infant and Preschool Assessment

ERIC Educational Resources Information Center

Zimmerman, Irla Lee; Castilleja, Nancy Flores

2005-01-01

The PLS-4 (Preschool Language Scale, 4th edition) is a psychometrically sound instrument constructed to assess language skills in children from birth to 6 years 11 months. It is a useful diagnostic and research tool that can be used to identify current comprehension and expressive language skills and can measure changes in language skills over…

Rockets Away! A Fun Approach to Exploring the Science of Rocketry. Teacher's Edition.

ERIC Educational Resources Information Center

Horton, Robert L.; And Others

This unit is designed to stimulate interest in math, engineering, aerospace, and physics through the exploration of rocketry science. It serves as a ready source of information dealing with the subject of rocketry and provides directions for completing a variety of hands-on rocketry science experiments, including the design, construction, and…

Ivins examines Destiny with the processing team in the SSPF

NASA Technical Reports Server (NTRS)

1999-01-01

In the Space Station Processing Facility, Marsha Ivins, a mission specialist on the STS-98 crew, inspects the U.S. Laboratory with members of the laboratory's processing team. The laboratory module, considered the centerpiece of the International Space Station (ISS), has been named 'Destiny' in honor of its prominent role in the world's largest science and technology effort. It is planned for launch aboard Space Shuttle Endeavour on the sixth ISS construction flight currently targeted for March 2000. From left to right are Ivins, Jerry Hopkins, Danny Whittington, Melissa Orozco, Vicki Reese and Suzanne Fase.

Ivins examines Destiny with the processing team in the SSPF

NASA Technical Reports Server (NTRS)

1999-01-01

In the Space Station Processing Facility, Marsha Ivins, a mission specialist on the STS-98 crew, inspects the U.S. Laboratory with members of the laboratory's processing team. The laboratory module, considered the centerpiece of the International Space Station (ISS), has been named 'Destiny' in honor of its prominent role in the world's largest science and technology effort. It is planned for launch aboard Space Shuttle Endeavour on the sixth ISS construction flight currently targeted for March 2000. From left to right are Ivins, Danny Whittington (face not visible), Melissa Orozco, Jerry Hopkins, and Suzanne Fase.

KSC-00padig063

NASA Image and Video Library

2000-10-31

A repair crew works to repair the broken cleat on the crawler-transporter, found as it was moving up the incline on Launch Pad 39B. The Shuttle retreated to level ground so the broken cleat could be repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1622

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is ready to move from the Vehicle Assembly Building into the light of early morning on its rollout to Launch Pad 39B. The Space Shuttle sits atop the Mobile Launcher Platform (MLP). Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1425

NASA Image and Video Library

2000-09-16

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility (OPF) bay 2 during Crew Equipment Interface Test (CEIT), Mission Specialists Joe Tanner (left) and Carlos Noriega (right) practice working parts of the Orbital Docking System (ODS) in Endeavour’s payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC00pp1420

NASA Image and Video Library

2000-09-16

In Orbiter Processing Facility bay 2 during a Crew Equipment Interface Test (CEIT), STS-97 Pilot Michael Bloomfied (left) and Commander Brent Jett (right) check out the cockpit of orbiter Endeavour as part of preflight preparations. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00pp1630

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- A repair crew works to remove a broken cleat (shoe) on the crawler-transporter moving the Space Shuttle Endeavour to Launch Pad 39B. The crack was noticed as the crawler-transporter started up the incline to the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1420

NASA Image and Video Library

2000-09-16

In Orbiter Processing Facility bay 2 during a Crew Equipment Interface Test (CEIT), STS-97 Pilot Michael Bloomfied (left) and Commander Brent Jett (right) check out the cockpit of orbiter Endeavour as part of preflight preparations. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC00pp1632

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Workers stand by while the broken cleat (shoe) on the crawler-transporter is removed. The crack was noticed as the crawler-transporter, moving Space Shuttle Endeavour to Launch Pad 39B, started up the incline to the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1631

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- A worker adjusts equipment to remove a broken cleat (shoe) on the crawler-transporter moving the Space Shuttle Endeavour to Launch Pad 39B. The crack was noticed as the crawler-transporter started up the incline to the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1421

NASA Image and Video Library

2000-09-16

In Orbiter Processing Facility bay 2 during a Crew Equipment Interface Test (CEIT), STS-97 Commander Brent Jett (left) and Pilot Michael Bloomfied (right) check out the cockpit of orbiter Endeavour as part of preflight preparations. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC00pp1630

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- A repair crew works to remove a broken cleat (shoe) on the crawler-transporter moving the Space Shuttle Endeavour to Launch Pad 39B. The crack was noticed as the crawler-transporter started up the incline to the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1632

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Workers stand by while the broken cleat (shoe) on the crawler-transporter is removed. The crack was noticed as the crawler-transporter, moving Space Shuttle Endeavour to Launch Pad 39B, started up the incline to the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1622

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is ready to move from the Vehicle Assembly Building into the light of early morning on its rollout to Launch Pad 39B. The Space Shuttle sits atop the Mobile Launcher Platform (MLP). Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1422

NASA Image and Video Library

2000-09-16

During a Crew Equipment Interface Test (CEIT), STS-97 Commander Brent Jett (left) and Pilot Michael Bloomfied (right) check out the cockpit of orbiter Endeavour in Orbiter Processing Facility bay 2 as part of preflight preparations. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC00pp1425

NASA Image and Video Library

2000-09-16

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility (OPF) bay 2 during Crew Equipment Interface Test (CEIT), Mission Specialists Joe Tanner (left) and Carlos Noriega (right) practice working parts of the Orbital Docking System (ODS) in Endeavour’s payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00pp1422

NASA Image and Video Library

2000-09-16

During a Crew Equipment Interface Test (CEIT), STS-97 Commander Brent Jett (left) and Pilot Michael Bloomfied (right) check out the cockpit of orbiter Endeavour in Orbiter Processing Facility bay 2 as part of preflight preparations. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00pp1421

NASA Image and Video Library

2000-09-16

In Orbiter Processing Facility bay 2 during a Crew Equipment Interface Test (CEIT), STS-97 Commander Brent Jett (left) and Pilot Michael Bloomfied (right) check out the cockpit of orbiter Endeavour as part of preflight preparations. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00pp1631

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- A worker adjusts equipment to remove a broken cleat (shoe) on the crawler-transporter moving the Space Shuttle Endeavour to Launch Pad 39B. The crack was noticed as the crawler-transporter started up the incline to the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

A repair crew works on crawler-transporter

NASA Technical Reports Server (NTRS)

2000-01-01

A repair crew works to repair the broken cleat on the crawler- transporter, found as it was moving up the incline on Launch Pad 39B. The Shuttle retreated to level ground so the broken cleat could be repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections.

STS-97 Mission Specialist Garneau with full launch and entry suit during pre-pack and fit check

NASA Technical Reports Server (NTRS)

2000-01-01

During pre-pack and fit check in the Operations and Checkout Building, STS-97 Commander Brent Jett gets help with his gloves from suit technician Bill Todd. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST.

STS-97 Mission Specialist Garneau during pre-pack and fit check

NASA Technical Reports Server (NTRS)

2000-01-01

STS-97 Mission Specialist Marc Garneau gets help with his boots from suit technician Tommy McDonald during pre-pack and fit check. Garneau is with the Canadian Space Agency. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST.

The STS-97 crew take part in CEIT

NASA Technical Reports Server (NTRS)

2000-01-01

In Orbiter Processing Facility (OPF) bay 2 during Crew Equipment Interface Test (CEIT), Mission Specialists Joe Tanner (left) and Carlos Noriega (right) practice working parts of the Orbital Docking System (ODS) in Endeavour's payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission.

[Tale nucleases--new tool for genome editing].

PubMed

Glazkova, D V; Shipulin, G A

2014-01-01

The ability to introduce targeted changes in the genome of living cells or entire organisms enables researchers to meet the challenges of basic life sciences, biotechnology and medicine. Knockdown of target genes in the zygotes gives the opportunity to investigate the functions of these genes in different organisms. Replacement of single nucleotide in the DNA sequence allows to correct mutations in genes and thus to cure hereditary diseases. Adding transgene to specific genomic.loci can be used in biotechnology for generation of organisms with certain properties or cell lines for biopharmaceutical production. Such manipulations of gene sequences in their natural chromosomal context became possible after the emergence of the technology called "genome editing". This technology is based on the induction of a double-strand break in a specific genomic target DNA using endonucleases that recognize the unique sequences in the genome and on subsequent recovery of DNA integrity through the use of cellular repair mechanisms. A necessary tool for the genome editing is a custom-designed endonuclease which is able to recognize selected sequences. The emergence of a new type of programmable endonucleases, which were constructed on the basis of bacterial proteins--TAL-effectors (Transcription activators like effector), has become an important stage in the development of technology and promoted wide spread of the genome editing. This article reviews the history of the discovery of TAL effectors and creation of TALE nucleases, and describes their advantages over zinc finger endonucleases that appeared earlier. A large section is devoted to description of genetic modifications that can be performed using the genome editing.

High-efficiency targeted editing of large viral genomes by RNA-guided nucleases.

PubMed

Bi, Yanwei; Sun, Le; Gao, Dandan; Ding, Chen; Li, Zhihua; Li, Yadong; Cun, Wei; Li, Qihan

2014-05-01

A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)) RNA-guided nuclease system can be introduced into host cells during viral replication. The CRISPR-Cas9 system robustly stimulates targeted double-stranded breaks in the genomes of DNA viruses, where the non-homologous end joining (NHEJ) and homology-directed repair (HDR) pathways can be exploited to introduce site-specific indels or insert heterologous genes with high frequency. Furthermore, CRISPR-Cas9 can specifically inhibit the replication of the original virus, thereby significantly increasing the abundance of the recombinant virus among progeny virus. As a result, purified recombinant virus can be obtained with only a single round of selection. In this study, we used recombinant adenovirus and type I herpes simplex virus as examples to demonstrate that the CRISPR-Cas9 system is a valuable tool for editing the genomes of large DNA viruses.

High-Efficiency Targeted Editing of Large Viral Genomes by RNA-Guided Nucleases

PubMed Central

Gao, Dandan; Ding, Chen; Li, Zhihua; Li, Yadong; Cun, Wei; Li, Qihan

2014-01-01

A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)) RNA-guided nuclease system can be introduced into host cells during viral replication. The CRISPR-Cas9 system robustly stimulates targeted double-stranded breaks in the genomes of DNA viruses, where the non-homologous end joining (NHEJ) and homology-directed repair (HDR) pathways can be exploited to introduce site-specific indels or insert heterologous genes with high frequency. Furthermore, CRISPR-Cas9 can specifically inhibit the replication of the original virus, thereby significantly increasing the abundance of the recombinant virus among progeny virus. As a result, purified recombinant virus can be obtained with only a single round of selection. In this study, we used recombinant adenovirus and type I herpes simplex virus as examples to demonstrate that the CRISPR-Cas9 system is a valuable tool for editing the genomes of large DNA viruses. PMID:24788700

Self-Cloning CRISPR.

PubMed

Arbab, Mandana; Sherwood, Richard I

2016-08-17

CRISPR/Cas9-gene editing has emerged as a revolutionary technology to easily modify specific genomic loci by designing complementary sgRNA sequences and introducing these into cells along with Cas9. Self-cloning CRISPR/Cas9 (scCRISPR) uses a self-cleaving palindromic sgRNA plasmid (sgPal) that recombines with short PCR-amplified site-specific sgRNA sequences within the target cell by homologous recombination to circumvent the process of sgRNA plasmid construction. Through this mechanism, scCRISPR enables gene editing within 2 hr once sgRNA oligos are available, with high efficiency equivalent to conventional sgRNA targeting: >90% gene knockout in both mouse and human embryonic stem cells and cancer cell lines. Furthermore, using PCR-based addition of short homology arms, we achieve efficient site-specific knock-in of transgenes such as GFP without traditional plasmid cloning or genome-integrated selection cassette (2% to 4% knock-in rate). The methods in this paper describe the most rapid and efficient means of CRISPR gene editing. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Exploring Quality Assurance in Sixth Form Colleges

ERIC Educational Resources Information Center

Stoten, David William

2012-01-01

Purpose: This paper aims to focus on the changing nature of quality assurance systems within the sixth form college sector. Design/methodology/approach: Ten sixth form colleges were surveyed across England and staff from varying levels within college hierarchies questioned about how quality assurance systems were implemented. Research involved…

An integrated CRISPR Bombyx mori genome editing system with improved efficiency and expanded target sites.

PubMed

Ma, Sanyuan; Liu, Yue; Liu, Yuanyuan; Chang, Jiasong; Zhang, Tong; Wang, Xiaogang; Shi, Run; Lu, Wei; Xia, Xiaojuan; Zhao, Ping; Xia, Qingyou

2017-04-01

Genome editing enabled unprecedented new opportunities for targeted genomic engineering of a wide variety of organisms ranging from microbes, plants, animals and even human embryos. The serial establishing and rapid applications of genome editing tools significantly accelerated Bombyx mori (B. mori) research during the past years. However, the only CRISPR system in B. mori was the commonly used SpCas9, which only recognize target sites containing NGG PAM sequence. In the present study, we first improve the efficiency of our previous established SpCas9 system by 3.5 folds. The improved high efficiency was also observed at several loci in both BmNs cells and B. mori embryos. Then to expand the target sites, we showed that two newly discovered CRISPR system, SaCas9 and AsCpf1, could also induce highly efficient site-specific genome editing in BmNs cells, and constructed an integrated CRISPR system. Genome-wide analysis of targetable sites was further conducted and showed that the integrated system cover 69,144,399 sites in B. mori genome, and one site could be found in every 6.5 bp. The efficiency and resolution of this CRISPR platform will probably accelerate both fundamental researches and applicable studies in B. mori, and perhaps other insects. Copyright © 2017 Elsevier Ltd. All rights reserved.

Using Stress Balls to Focus the Attention of Sixth-Grade Learners

ERIC Educational Resources Information Center

Stalvey, Sheryl; Brasell, Heather

2006-01-01

This pilot study investigated the effects of allowing sixth-grade students in a rural south Georgia school to use stress balls during direct instruction and independent practice. Data from learning style inventories, surveys, journals, teacher observations, and formal assessments were collected for 29 sixth-grade students in a language arts class.…

Prediction and Stability of Reading Problems in Middle Childhood

ERIC Educational Resources Information Center

Ritchey, Kristen D.; Silverman, Rebecca D.; Schatschneider, Christopher; Speece, Deborah L.

2015-01-01

The longitudinal prediction of reading problems from fourth grade to sixth grade was investigated with a sample of 173 students. Reading problems at the end of sixth grade were defined by significantly below average performance (= 15th percentile) on reading factors defining word reading, fluency, and reading comprehension. Sixth grade poor reader…

Factors Influencing Mathematic Problem-Solving Ability of Sixth Grade Students

ERIC Educational Resources Information Center

Pimta, Sakorn; Tayraukham, Sombat; Nuangchalerm, Prasart

2009-01-01

Problem statement: This study aims to investigate factors influencing mathematic problem-solving ability of sixth grade students. One thousand and twenty eight of sixth grade students, studying in the second semester of academic year 2007 were sampled by stratified random sampling technique. Approach: The research instruments used in the study…

The Content Analysis of Sixth Grade Computer Textbooks

ERIC Educational Resources Information Center

Keser, Hafize; Aydin, Burcu

2007-01-01

In this study, the content analysis' categories and sub topics were drawn up for sixth and seventh grade computer textbooks in order to compare visual and verbal contents of these textbooks. Totally nine sixth and seventh grade computer textbooks which were chosen by Ministry of National Education were included in this study. These nine textbooks…

Newspapers in Science Education: A Study Involving Sixth Grade Students

ERIC Educational Resources Information Center

Lai, Ching-San; Wang, Yun-Fei

2016-01-01

The purpose of this study was to explore the learning performance of sixth grade elementary school students using newspapers in science teaching. A quasi-experimental design with a single group was used in this study. Thirty-three sixth grade elementary school students participated in this study. The research instruments consisted of three…

75 FR 20556 - Announcement of the Sixth and Final Dietary Guidelines Advisory Committee Meeting and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... Economics (REE); and U.S. Department of Health and Human Services (HHS), Office of Public Health and Science... DEPARTMENT OF AGRICULTURE DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of the Sixth and... Human Services (HHS) (a) provide notice of the sixth and final meeting of the Dietary Guidelines...

Connecting Content, Context, and Communication in a Sixth-Grade Social Studies Class through Political Cartoons

ERIC Educational Resources Information Center

Gallavan, Nancy P.; Webster-Smith, Angela; Dean, Sheila S.

2012-01-01

Sixth-grade students are challenged in understanding social studies content relevant to particular contexts, then connecting the content and context to their contemporary lives while communicating new knowledge to peers and teachers. Using political cartoons published after September 11, 2001, one sixth-grade social studies teacher designed…

Greening Federal Facilities: An Energy, Environmental, and Economic Resource Guide for Federal Facility Managers and Designers; Second Edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilson, A.

2001-05-16

Greening Federal Facilities, Second Edition, is a nuts-and-bolts resource guide compiled to increase energy and resource efficiency, cut waste, and improve the performance of Federal buildings and facilities. The guide highlights practical actions that facility managers, design and construction staff, procurement officials, and facility planners can take to save energy and money, improve the comfort and productivity of employees, and benefit the environment. It supports a national effort to promote energy and environmental efficiency in the nation's 500,000 Federal buildings and facilities. Topics covered include current Federal regulations; environmental and energy decision-making; site and landscape issues; building design; energy systems;more » water and wastewater; materials; waste management, and recycling; indoor environmental quality; and managing buildings.« less

How To Eliminate Narcissism Overnight: DSM-V and the Death of Narcissistic Personality Disorder.

PubMed

Pies, Ronald

2011-02-01

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition appears likely to eliminate the diagnosis of narcissistic personality disorder. There are significant problems with the discriminant validity of the current narcissistic personality disorder critiera set; furthermore, the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition's narrow focus on "grandiosity" probably contributes to the wide disparity between low narcissistic personality disorder prevalence rates in epidemiological studies and high rates of narcissistic personality disorder in clinical practice. Nevertheless, the best course of action may be to refine the narcissistic personality disorder criteria, followed by careful field testing and a search for biomarkers, rather than wholesale elimination of the narcissistic personality disorder category. The construct of "malignant narcissism" is also worthy of more intense empirical investigation.

Confirmatory factor analysis of the School Refusal Assessment Scale – Revised in an African American community sample

PubMed Central

Lyon, Aaron R.

2010-01-01

The current study used confirmatory factor analysis techniques to investigate the construct validity of the child version of the School Refusal Assessment Scale – Revised (SRAS-R) in a community sample of low socioeconomic status, urban, African American fifth and sixth graders (n = 174). The SRAS-R is the best-researched measure of school refusal behavior in youth and typically yields four functional dimensions. Results of the investigation suggested that a modified version of the four-factor model, in which three items from the tangible reinforcement dimension are removed, may have construct validity in the current sample of youth. In addition, youth endorsement of the dimension measuring avoidance of social and/or evaluative situations was positively associated with unexcused absences. Implications for further psychometric research and early identification and prevention of problematic absenteeism in low-SES, ethnic minority community samples are highlighted. PMID:20567603

Precision Magnetic Bearing Six Degree of Freedom Stage

NASA Technical Reports Server (NTRS)

Williams, M. E.; Trumper, David L.

1996-01-01

Magnetic bearings are capable of applying force and torque to a suspended object without rigidly constraining any degrees of freedom. Additionally, the resolution of magnetic bearings is limited only by sensors and control, and not by the finish of a bearing surface. For these reasons, magnetic bearings appear to be ideal for precision wafer positioning in lithography systems. To demonstrate this capability a linear magnetic bearing has been constructed which uses variable reluctance actuators to control the motion of a 14.5 kg suspended platen in five degrees of freedom. A Lorentz type linear motor of our own design and construction is used to provide motion and position control in the sixth degree of freedom. The stage performance results verify that the positioning requirements of photolithography can be met with a system of this type. This paper describes the design, control, and performance of the linear magnetic bearing.

The effect of gravity on plant germination

NASA Astrophysics Data System (ADS)

Takakura, T.; Goto, E.; Tanaka, M.

1996-01-01

An axis clinostat was constructed to create micro and negative gravity also a rotated flat disk was constructed with different rotation rates to give increased gravity, by centrifugal force up to 48g. Rice seeds were grown on agar in tubes at the constant air temperature of 20 degC under an average light condition of 110 mumol/m^2/sec(PPF). Humidity was not controlled but was maintained above 90%. Since the tube containers were not large enough for long cultivation, shoot and root growth were observed every 12 hours until the sixth day from seeding. The lengths of shoots and roots for each individual plant were measured on the last day. The stem lengths were increased by microgravity but the root lengths were not. Under the negative gravity, negative orthogeotropism and under micro gravity, diageotropism was observed. No significant effect of increased gravity was observed on shoot and root growth.

KSC-00pp1568

NASA Image and Video Library

2000-10-11

STS-92 Mission Specialist Leroy Chiao waves while waiting for suit check in the White Room. Behind him is Commander Brian Duffy. The White Room is an environmentally controlled area at the end of the Orbiter Access Arm that provides entry to the orbiter as well as emergency egress if needed. The arm remains in the extended position until 7 minutes 24 seconds before launch. Chiao, Duffy and the rest of the crew are undertaking the fifth flight to the International Space Station for construction. Discovery carries a payload that includes the Integrated Truss Structure Z-1, first of 10 trusses that will form the backbone of the Space Station, and the third Pressurized Mating Adapter that will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. The mission includes four spacewalks for the construction activities. Discovery’s landing is expected Oct. 22 at 2:10 p.m. EDT

KSC-00pp1563

NASA Image and Video Library

2000-10-11

STS-92 Mission Specialist William S. McArthur Jr. undergoes final suit check in the White Room before entering Discovery. The White Room is an environmentally controlled area at the end of the Orbiter Access Arm that provides entry to the orbiter as well as emergency egress if needed. The arm remains in the extended position until 7 minutes 24 seconds before launch. McArthur and the rest of the crew are making the fifth flight to the International Space Station for construction. Discovery carries a payload that includes the Integrated Truss Structure Z-1, first of 10 trusses that will form the backbone of the Space Station, and the third Pressurized Mating Adapter that will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. The mission includes four spacewalks for the construction activities. Discovery’s landing is expected Oct. 22 at 2:10 p.m. EDT

KSC-00pp1569

NASA Image and Video Library

2000-10-11

STS-92 Commander Brian Duffy is helped with final suit check in the White Room before entering Discovery. The White Room is an environmentally controlled area at the end of the Orbiter Access Arm that provides entry to the orbiter as well as emergency egress if needed. The arm remains in the extended position until 7 minutes 24 seconds before launch. Duffy and the rest of the crew are undertaking the fifth flight to the International Space Station for construction. Discovery carries a payload that includes the Integrated Truss Structure Z-1, first of 10 trusses that will form the backbone of the Space Station, and the third Pressurized Mating Adapter that will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. The mission includes four spacewalks for the construction activities. Discovery’s landing is expected Oct. 22 at 2:10 p.m. EDT

KSC-00pp1567

NASA Image and Video Library

2000-10-11

STS-92 Pilot Pamela Ann Melroy has a final check on her launch and entry suit in the White Room before entering Discovery. The White Room is an environmentally controlled area at the end of the Orbiter Access Arm that provides entry to the orbiter as well as emergency egress if needed. The arm remains in the extended position until 7 minutes 24 seconds before launch. Melroy and the rest of the crew are undertaking the fifth flight to the International Space Station for construction. Discovery carries a payload that includes the Integrated Truss Structure Z-1, first of 10 trusses that will form the backbone of the Space Station, and the third Pressurized Mating Adapter that will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. The mission includes four spacewalks for the construction activities. Discovery’s landing is expected Oct. 22 at 2:10 p.m. EDT

Benchmarking of TALE- and CRISPR/dCas9-Based Transcriptional Regulators in Mammalian Cells for the Construction of Synthetic Genetic Circuits.

PubMed

Lebar, Tina; Jerala, Roman

2016-10-21

Transcriptional activator-like effector (TALE)- and CRISPR/Cas9-based designable recognition domains represent a technological breakthrough not only for genome editing but also for building designed genetic circuits. Both platforms are able to target rarely occurring DNA segments, even within complex genomes. TALE and dCas9 domains, genetically fused to transcriptional regulatory domains, can be used for the construction of engineered logic circuits. Here we benchmarked the performance of the two platforms, targeting the same DNA sequences, to compare their advantages for the construction of designed circuits in mammalian cells. Optimal targeting strands for repression and activation of dCas9-based designed transcription factors were identified; both platforms exhibited good orthogonality and were used to construct functionally complete NOR gates. Although the CRISPR/dCas9 system is clearly easier to construct, TALE-based activators were significantly stronger, and the TALE-based platform performed better, especially for the construction of layered circuits.

Introduction to Heating, Ventilation and Air Conditioning (HVAC). Introduction to Construction Series. Instructor Edition.

ERIC Educational Resources Information Center

Associated General Contractors of America, Washington, DC.

This module on introductory heating, ventilating, and air conditioning (HVAC) is one of a series of modules designed to teach basic skills necessary for entry-level employment in this field. The module contains four instructional units that cover the following topics: (1) HVAC materials; (2) HVAC tools; (3) HVAC layout; and (4) HVAC basic skills.…

Matematica Para La Escuela Secundaria: Geometria (Parte 1). Traduccion Preliminar de la Edicion Inglesa Revisada. (Mathematics for High School: Geometry, Part 1. Preliminary Translation of the Revised English Edition).

ERIC Educational Resources Information Center

Allen, Frank B.; And Others

This is part one of a two-part SMSG mathematics text for high school students. Topics include plane geometry, real numbers, triangles and angles, congruence, construction, parallel lines, perpendicular lines, and parallelograms. The text is written in Spanish. (RH)

Educational Issues in Utah: Governance, Legislation, Technology, and Finance. 1994-95 Conditions of Education in Utah Yearbook.

ERIC Educational Resources Information Center

Galvin, Patrick F., Ed.; Johnson, Bob L., Jr., Ed.

This document is the third edition of "Conditions of Education in Utah," covering the 1994-95 academic year. The first three chapters analyze issues relative to distance education and the Internet. Chapters 1 and 2 examine the pros and cons of distance education, and chapter 3 describes the construction, maintenance, and staffing costs…

Automated Scoring for the "TOEFL Junior"® Comprehensive Writing and Speaking Test. Research Report. ETS RR-15-09

ERIC Educational Resources Information Center

Evanini, Keelan; Heilman, Michael; Wang, Xinhao; Blanchard, Daniel

2015-01-01

This report describes the initial automated scoring results that were obtained using the constructed responses from the Writing and Speaking sections of the pilot forms of the "TOEFL Junior"® Comprehensive test administered in late 2011. For all of the items except one (the edit item in the Writing section), existing automated scoring…

CRISPR/Cas9-mediated targeted mutagenesis in grape

PubMed Central

Ban, Yusuke; Azuma, Akifumi; Onoue, Noriyuki; Moriguchi, Takaya; Yamamoto, Toshiya; Toki, Seiichi

2017-01-01

RNA-guided genome editing using the CRISPR/Cas9 CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) system has been applied successfully in several plant species. However, to date, there are few reports on the use of any of the current genome editing approaches in grape—an important fruit crop with a large market not only for table grapes but also for wine. Here, we report successful targeted mutagenesis in grape (Vitis vinifera L., cv. Neo Muscat) using the CRISPR/Cas9 system. When a Cas9 expression construct was transformed to embryonic calli along with a synthetic sgRNA expression construct targeting the Vitis vinifera phytoene desaturase (VvPDS) gene, regenerated plants with albino leaves were obtained. DNA sequencing confirmed that the VvPDS gene was mutated at the target site in regenerated grape plants. Interestingly, the ratio of mutated cells was higher in lower, older, leaves compared to that in newly appearing upper leaves. This result might suggest either that the proportion of targeted mutagenized cells is higher in older leaves due to the repeated induction of DNA double strand breaks (DSBs), or that the efficiency of precise DSBs repair in cells of old grape leaves is decreased. PMID:28542349

High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of NCED4 in Lettuce (Lactuca sativa).

PubMed

Bertier, Lien D; Ron, Mily; Huo, Heqiang; Bradford, Kent J; Britt, Anne B; Michelmore, Richard W

2018-05-04

CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary transformants. However, many of the mutations analyzed were somatic and therefore not heritable. To provide more insights into the efficiency of creating stable homozygous mutants using CRISPR/Cas9, we targeted LsNCED4 ( 9-cis-EPOXYCAROTENOID DIOXYGENASE4) , a gene conditioning thermoinhibition of seed germination in lettuce. Three constructs, each capable of expressing Cas9 and a single gRNA targeting different sites in LsNCED4 , were stably transformed into lettuce (Lactuca sativa) cvs. Salinas and Cobham Green. Analysis of 47 primary transformants (T 1 ) and 368 T 2 plants by deep amplicon sequencing revealed that 57% of T 1 plants contained events at the target site: 28% of plants had germline mutations in one allele indicative of an early editing event (mono-allelic), 8% of plants had germline mutations in both alleles indicative of two early editing events (bi-allelic), and the remaining 21% of plants had multiple low frequency mutations indicative of late events (chimeric plants). Editing efficiency was similar in both genotypes, while the different gRNAs varied in efficiency. Amplicon sequencing of 20 T 1 and more than 100 T 2 plants for each of the three gRNAs showed that repair outcomes were not random, but reproducible and characteristic for each gRNA. Knockouts of NCED4 resulted in large increases in the maximum temperature for seed germination, with seeds of both cultivars capable of germinating >70% at 37°. Knockouts of NCED4 provide a whole-plant selectable phenotype that has minimal pleiotropic consequences. Targeting NCED4 in a co-editing strategy could therefore be used to enrich for germline-edited events simply by germinating seeds at high temperature. Copyright © 2018 Bertier et al.

High-Resolution Analysis of the Efficiency, Heritability, and Editing Outcomes of CRISPR/Cas9-Induced Modifications of NCED4 in Lettuce (Lactuca sativa)

PubMed Central

Bertier, Lien D.; Ron, Mily; Huo, Heqiang; Bradford, Kent J.; Britt, Anne B.; Michelmore, Richard W.

2018-01-01

CRISPR/Cas9 is a transformative tool for making targeted genetic alterations. In plants, high mutation efficiencies have been reported in primary transformants. However, many of the mutations analyzed were somatic and therefore not heritable. To provide more insights into the efficiency of creating stable homozygous mutants using CRISPR/Cas9, we targeted LsNCED4 (9-cis-EPOXYCAROTENOID DIOXYGENASE4), a gene conditioning thermoinhibition of seed germination in lettuce. Three constructs, each capable of expressing Cas9 and a single gRNA targeting different sites in LsNCED4, were stably transformed into lettuce (Lactuca sativa) cvs. Salinas and Cobham Green. Analysis of 47 primary transformants (T1) and 368 T2 plants by deep amplicon sequencing revealed that 57% of T1 plants contained events at the target site: 28% of plants had germline mutations in one allele indicative of an early editing event (mono-allelic), 8% of plants had germline mutations in both alleles indicative of two early editing events (bi-allelic), and the remaining 21% of plants had multiple low frequency mutations indicative of late events (chimeric plants). Editing efficiency was similar in both genotypes, while the different gRNAs varied in efficiency. Amplicon sequencing of 20 T1 and more than 100 T2 plants for each of the three gRNAs showed that repair outcomes were not random, but reproducible and characteristic for each gRNA. Knockouts of NCED4 resulted in large increases in the maximum temperature for seed germination, with seeds of both cultivars capable of germinating >70% at 37°. Knockouts of NCED4 provide a whole-plant selectable phenotype that has minimal pleiotropic consequences. Targeting NCED4 in a co-editing strategy could therefore be used to enrich for germline-edited events simply by germinating seeds at high temperature. PMID:29511025

Readability of arthroscopy-related patient education materials from the American Academy of Orthopaedic Surgeons and Arthroscopy Association of North America Web sites.

PubMed

Yi, Paul H; Ganta, Abhishek; Hussein, Khalil I; Frank, Rachel M; Jawa, Andrew

2013-06-01

We sought to assess the readability levels of arthroscopy-related patient education materials available on the Web sites of the American Academy of Orthopaedic Surgeons (AAOS) and the Arthroscopy Association of North America (AANA). We identified all articles related to arthroscopy available in 2012 from the online patient education libraries of AAOS and AANA. After performing follow-up editing, we assessed each article with the Flesch-Kincaid (FK) readability test. Mean readability levels of the articles from the AAOS Web site and the AANA Web site were compared. We also determined the number of articles with readability levels at or below the eighth-grade level (the average reading ability of the US adult population) and sixth-grade level (the widely recommended level for patient education materials). Intraobserver reliability and interobserver reliability of FK grade assessment were evaluated. A total of 62 articles were reviewed (43 from AAOS and 19 from AANA). The mean overall FK grade level was 10.2 (range, 5.2 to 12). The AAOS articles had a mean FK grade level of 9.6 (range, 5.2 to 12), whereas the AANA articles had a mean FK grade level of 11.4 (range, 8.7 to 12); the difference was significant (P < .0001). Only 3 articles had a readability level at or below the eighth-grade level and only 1 was at or below the sixth-grade level; all were from AAOS. Intraobserver reliability and interobserver reliability were excellent (intraclass correlation coefficient of 1 for both). Online patient education materials related to arthroscopy from AAOS and AANA may be written at a level too difficult for a large portion of the patient population to comprehend. Copyright © 2013 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Assessing the Readability of Online Information About Hip Arthroscopy.

PubMed

Mehta, Manish P; Swindell, Hasani W; Westermann, Robert W; Rosneck, James T; Lynch, T Sean

2018-04-06

To investigate the current readability of online information pertaining to hip arthroscopy. The terms "hip arthroscopy" and "hip scope" were entered into the advanced search functions of Google, Yahoo!, and Bing on March 25, 2017, and results from the first 3 pages were analyzed. Results were required to be unique, accessible websites with information about hip arthroscopy conveyed primarily via analyzable text. Two reviewers applied inclusion criteria to the initial 97 results, discussing to reach consensus in cases of disagreement. Overall, 60 unique results were reviewed with 48 meeting inclusion criteria. Websites were categorized as physician-sponsored, academic, commercial, governmental and nonprofit organization (NPO), or unspecified. Readability was measured via 6 different indices: the Flesch-Kincaid grade level (FKGL), Flesch Reading Ease (FRE), Gunning Fog Score, SMOG Index, Coleman-Liau Index (CLI), and Automated Readability Index (ARI) along with an average grade level and readability classification score. Forty-eight unique websites were assessed for readability, with physician-sponsored webpages composing the majority (47.92%) followed by academic sources (35.42%). The webpages' average grade level, incorporating information from all 6 metrics, was 12.79 ± 1.98. The current readability of online information pertaining to hip arthroscopy is at an inappropriately high reading level compared with the sixth-grade level recommended by the American Medical Association and National Institutes of Health, thus introducing significant barriers to understanding for many patients. Online materials should be edited to reduce word and sentence length and complexity, use simpler terms, and minimize use of passive voice to facilitate patient knowledge acquisition and understanding of online information about hip arthroscopy. This study shows that the current readability of online information on hip arthroscopy exceeds the suggested sixth-grade reading level. It also emphasizes the need for simplifying written materials and offers specific suggestions on doing so to increase accessibility of information for patients. Copyright © 2018 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Reform-Based Curriculum & Acquisition of the Levels

ERIC Educational Resources Information Center

Halat, Erdogan

2007-01-01

The aim of this study was to compare the acquisition of the van Hiele levels of sixth-grade students engaged in instruction using a reform-based curriculum with sixth-grade students engaged in instruction using a traditional curriculum. There were 273 sixth-grade mathematics students, 123 in the control group and 150 in the treatment group,…

Teacher Competence and the Academic Achievement of Sixth Grade Students in Uganda

ERIC Educational Resources Information Center

Wamala, Robert; Seruwagi, Gerald

2013-01-01

The study investigates the influence of teacher competence on the academic achievement of sixth grade students in Uganda. The investigation is based on data sourced from the 2009 Southern African Consortium for Monitoring Education Quality (SACMEQ) survey comprising 5,148 records of sixth grade students enrolled in primary schools in Uganda. The…

The Interdependence of Sixth Graders' School Attitudes and Academic Performance.

ERIC Educational Resources Information Center

Glick, Oren

In this study, data were obtained from sixth grade students on attitudes toward each of four aspects of the school experience and on academic achievement. Data were available from 159 males and 199 females from 17 sixth grade classrooms in 17 schools within the Kansas City school district. Attitudes toward school were measured with the Pupil…

Finding Their Voices: A Narrative Inquiry of Sixth-Grade Lumbee Males Who Struggle with Reading

ERIC Educational Resources Information Center

Fletcher, Michael Shane

2016-01-01

This narrative inquiry collective case study investigated the experiences of six sixth grade American Indian males of the Lumbee tribe who struggle with reading. Bounded within an asynchronous closed wiki site, students from three sixth grade classes participated in online threaded discussions and created, posted, and viewed multimedia projects…

Physical Activity of Fifth to Sixth Graders during School Hours According to School Race/Ethnicity: Suburban Cook County, Illinois

ERIC Educational Resources Information Center

Kwon, Soyang; Mason, Maryann; Welch, Sarah

2015-01-01

Background: We compared moderate-to-vigorous intensity physical activity (MVPA) and inactivity levels among fifth and sixth graders during school hours according to school-level race/ethnicity and income attributes to inform school-based obesity interventions in Illinois Suburban Cook County (SCC). Methods: Fifth- and sixth-grade students…

The Effect of Self-Regulated Learning on Sixth-Grade Turkish Students' Mathematics Achievements and Motivational Beliefs

ERIC Educational Resources Information Center

Yidizli, Hülya; Saban, Ahmet

2016-01-01

This study examined the effect of self-regulated learning on sixth-grade Turkish students' mathematics achievements and motivational beliefs. Both quantitative and qualitative research methods were used in the study. Participants included sixth-grade students attending at TOKI 125. Year Middle School in Nevsehir (Turkey) during the 2014-2015…

A Novel Prokaryotic Green Fluorescent Protein Expression System for Testing Gene Editing Tools Activity Like Zinc Finger Nuclease.

PubMed

Sabzehei, Faezeh; Kouhpayeh, Shirin; Dastjerdeh, Mansoureh Shahbazi; Khanahmad, Hossein; Salehi, Rasoul; Naderi, Shamsi; Taghizadeh, Razieh; Rabiei, Parisa; Hejazi, Zahra; Shariati, Laleh

2017-01-01

Gene editing technology has created a revolution in the field of genome editing. The three of the most famous tools in gene editing technology are zinc finger nucleases (ZFNs), transcription activator-like effector nucleases, clustered regularly interspaced short palindromic repeats (CRISPR), and CRISPR-associated systems. As their predictable nature, it is necessary to assess their efficiency. There are some methods for this purpose, but most of them are time labor and complicated. Here, we introduce a new prokaryotic reporter system, which makes it possible to evaluate the efficiency of gene editing tools faster, cheaper, and simpler than previous methods. At first, the target sites of a custom ZFN, which is designed against a segment of ampicillin resistance gene, were cloned on both sides of green fluorescent protein (GFP) gene to construct pPRO-GFP. Then pPRO-GFP was transformed into Escherichia coli TOP10F' that contains pZFN (contains expression cassette of a ZFN against ampicillin resistant gene), or p15A-KanaR as a negative control. The transformed bacteria were cultured on three separate media that contained ampicillin, kanamycin, and ampicillin + kanamycin; then the resulted colonies were assessed by flow cytometry. The results of flow cytometry showed a significant difference between the case (bacteria contain pZFN) and control (bacteria contain p15A, KanaR) in MFI (Mean Fluorescence Intensity) ( P < 0.0001). According to ZFN efficiency, it can bind and cut the target sites, the bilateral cutting can affect the intensity of GFP fluorescence. Our flow cytometry results showed that this ZFN could reduce the intensity of GFP color and colony count of bacteria in media containing amp + kana versus control sample.

First-in-human Phase 1 CRISPR Gene Editing Cancer Trials: Are We Ready?

PubMed

Baylis, Francoise; McLeod, Marcus

2017-01-01

A prospective first-in-human Phase 1 CRISPR gene editing trial in the United States for patients with melanoma, synovial sarcoma, and multiple myeloma offers hope that gene editing tools may usefully treat human disease. An overarching ethical challenge with first-in-human Phase 1 clinical trials, however, is knowing when it is ethically acceptable to initiate such trials on the basis of safety and efficacy data obtained from pre-clinical studies. If the pre-clinical studies that inform trial design are themselves poorly designed - as a result of which the quality of pre-clinical evidence is deficient - then the ethical requirement of scientific validity for clinical research may not be satisfied. In turn, this could mean that the Phase 1 clinical trial will be unsafe and that trial participants will be exposed to risk for no potential benefit. To assist sponsors, researchers, clinical investigators and reviewers in deciding when it is ethically acceptable to initiate first-in-human Phase 1 CRISPR gene editing clinical trials, structured processes have been developed to assess and minimize translational distance between pre-clinical and clinical research. These processes draw attention to various features of internal validity, construct validity, and external validity. As well, the credibility of supporting evidence is to be critically assessed with particular attention to optimism bias, financial conflicts of interest and publication bias. We critically examine the pre-clinical evidence used to justify the first-inhuman Phase 1 CRISPR gene editing cancer trial in the United States using these tools. We conclude that the proposed trial cannot satisfy the ethical requirement of scientific validity because the supporting pre-clinical evidence used to inform trial design is deficient. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

A Novel Prokaryotic Green Fluorescent Protein Expression System for Testing Gene Editing Tools Activity Like Zinc Finger Nuclease

PubMed Central

Sabzehei, Faezeh; Kouhpayeh, Shirin; Dastjerdeh, Mansoureh Shahbazi; Khanahmad, Hossein; Salehi, Rasoul; Naderi, Shamsi; Taghizadeh, Razieh; Rabiei, Parisa; Hejazi, Zahra; Shariati, Laleh

2017-01-01

Background: Gene editing technology has created a revolution in the field of genome editing. The three of the most famous tools in gene editing technology are zinc finger nucleases (ZFNs), transcription activator-like effector nucleases, clustered regularly interspaced short palindromic repeats (CRISPR), and CRISPR-associated systems. As their predictable nature, it is necessary to assess their efficiency. There are some methods for this purpose, but most of them are time labor and complicated. Here, we introduce a new prokaryotic reporter system, which makes it possible to evaluate the efficiency of gene editing tools faster, cheaper, and simpler than previous methods. Materials and Methods: At first, the target sites of a custom ZFN, which is designed against a segment of ampicillin resistance gene, were cloned on both sides of green fluorescent protein (GFP) gene to construct pPRO-GFP. Then pPRO-GFP was transformed into Escherichia coli TOP10F’ that contains pZFN (contains expression cassette of a ZFN against ampicillin resistant gene), or p15A-KanaR as a negative control. The transformed bacteria were cultured on three separate media that contained ampicillin, kanamycin, and ampicillin + kanamycin; then the resulted colonies were assessed by flow cytometry. Results: The results of flow cytometry showed a significant difference between the case (bacteria contain pZFN) and control (bacteria contain p15A, KanaR) in MFI (Mean Fluorescence Intensity) (P < 0.0001). Conclusion: According to ZFN efficiency, it can bind and cut the target sites, the bilateral cutting can affect the intensity of GFP fluorescence. Our flow cytometry results showed that this ZFN could reduce the intensity of GFP color and colony count of bacteria in media containing amp + kana versus control sample. PMID:29285485

Hepatitis D virus RNA editing is inhibited by a GFP fusion protein containing a C-terminally deleted delta antigen.

PubMed

Shih, Ko-Nien; Chuang, Ya-Ting; Liu, Hsuan; Lo, Szecheng J

2004-04-01

During its life cycle, hepatitis D virus (HDV) produces two forms of delta antigen (HDAg), small delta antigen (SDAg) and large delta antigen (LDAg), which differ in their C-terminal 19 amino acids. Host enzymes termed ADARs (adenosine deaminases that act on double-stranded RNA) are required for LDAg production. These enzymes change the stop codon (UAG) of SDAg to a tryptophan codon (UGG). However, the temporal and spatial regulation of HDV RNA editing is largely unknown. In this study, we constructed three GFP fusion proteins containing different lengths of SDAg and characterized their cellular localization and effects on HDV replication. One of these fusion proteins, designated D(1-88)-GFP, inhibited LDAg but not SDAg production, suggesting that D(1-88)-GFP inhibits HDV RNA editing. Two experiments further supported this supposition: (i). RT-PCR analysis combined with NcoI restriction enzyme digestion revealed that HDV RNA editing was reduced by 42% in HeLa-D(1-88)-GFP when compared with HeLa cells; and (ii). the ratio of SDAg/LDAg production from the reporter RNAs was reduced in cells co-transfected with ADAR-expressing and reporter plasmids in the presence of D(1-88)-GFP. Double fluorescence microscopy found that D(1-88)-GFP was either associated with SC-35 or was adjacent to PML (premyelocytic leukaemia antigen) at nuclear speckles, but D(1-88)-GFP was not co-localized with ADAR, which was mainly located in the nucleolus. In situ hybridization showing co-localization of HDV RNA with D(1-88)-GFP at nuclear speckles suggested that HDV RNA editing might occur in the nuclear speckles and require other nuclear factor(s), in addition to ADAR.

Ground-water conditions in Utah, spring of 1999

USGS Publications Warehouse

Burden, Carole B.; Spangler, L.E.; Sory, J.D.; Eacret, Robert J.; Kenney, T.A.; Johnson, K.K.; Loving, B.L.; Brockner, S.J.; Danner, M.R.; Downhour, Paul; Slaugh, B.A.; Swenson, R.L.; Howells, J.H.; Christiansen, H.K.; Fisher, M.J.

1999-01-01

This is the thirty-sixth in a series of annual reports that describe ground-water conditions in Utah. Reports in this series, published cooperatively by the U.S. Geological Survey and the Utah Department of Natural Resources, Division of Water Resources and Division of Water Rights, provide data to enable interested parties to maintain awareness of changing ground-water conditions.This report, like the others in the series, contains information on well construction, ground-water withdrawal from wells, water-level changes, precipitation, streamflow, and chemical quality of water. Information on well construction included in this report refers only to wells constructed for new appropriations of ground water. Supplementary data are included in reports of this series only for those years or areas which are important to a discussion of changing ground-water conditions and for which applicable data are available.This report includes individual discussions of selected significant areas of ground-water development in the State for calendar year 1998. Most of the reported data were collected by the U.S. Geological Survey in cooperation with the Utah Department of Natural Resources, Divisions of Water Rights and Water Resources.

Use of a modified Comprehensive Pain Evaluation Questionnaire: Characteristics and functional status of patients on entry to a tertiary care pain clinic

PubMed Central

Nelli, Jennifer M; Nicholson, Keith; Lakha, S Fatima; Louffat, Ada F; Chapparo, Luis; Furlan, Julio; Mailis-Gagnon, Angela

2012-01-01

BACKGROUND: With increasing knowledge of chronic pain, clinicians have attempted to assess chronic pain patients with lengthy assessment tools. OBJECTIVES: To describe the functional and emotional status of patients presenting to a tertiary care pain clinic; to assess the reliability and validity of a diagnostic classification system for chronic pain patients modelled after the Multidimensional Pain Inventory; to provide psychometric data on a modified Comprehensive Pain Evaluation Questionnaire (CPEQ); and to evaluate the relationship between the modified CPEQ construct scores and clusters with Diagnostic and Statistical Manual, Fourth Edition – Text Revision Pain Disorder diagnoses. METHODS: Data on 300 new patients over the course of nine months were collected using standardized assessment procedures plus a modified CPEQ at the Comprehensive Pain Program, Toronto Western Hospital, Toronto, Ontario. RESULTS: Cluster analysis of the modified CPEQ revealed three patient profiles, labelled Adaptive Copers, Dysfunctional, and Interpersonally Distressed, which closely resembled those previously reported. The distribution of modified CPEQ construct T scores across profile subtypes was similar to that previously reported for the original CPEQ. A novel finding was that of a strong relationship between the modified CPEQ clusters and constructs with Diagnostic and Statistical Manual, Fourth Edition – Text Revision Pain Disorder diagnoses. DISCUSSION AND CONCLUSIONS: The CPEQ, either the original or modified version, yields reproducible results consistent with the results of other studies. This technique may usefully classify chronic pain patients, but more work is needed to determine the meaning of the CPEQ clusters, what psychological or biomedical variables are associated with CPEQ constructs or clusters, and whether this instrument may assist in treatment planning or predict response to treatment. PMID:22518368

Middle-Class Struggle? Identity-Work and Leisure among Sixth Formers in the United Kingdom

ERIC Educational Resources Information Center

Kehily, Mary Jane; Pattman, Rob

2006-01-01

This paper explores the ways in which sixth-form students in Milton Keynes negotiate their identities and the symbolic significance they attach to leisure activities in the process of doing this. The paper draws upon qualitative, young-person-centred interviews with sixth formers in state and private schools. It addresses the investments of sixth…

Examining Sixth Grade Students' Reading Attitudes and Perceptions of Teacher Read Aloud: Are All Students on the Same Page?

ERIC Educational Resources Information Center

Clark, Sarah K.; Andreasen, Lindi

2014-01-01

The purpose of this embedded mixed methods study was to examine how sixth graders with high and low reading attitudes perceive teacher read aloud. We utilized quantitative data by surveying sixth graders (N = 87) about their reading attitudes and then collected qualitative data by interviewing five students, interviewing the teacher, conducting…

A Case Study on the Spatial Conceptualization Abilities for Sixth Grade Elementary Students from Urban, Suburban and Remote Schools

ERIC Educational Resources Information Center

Chao, Jen Yi; Liu, Chuan Hsi

2017-01-01

The main objective of this study was to investigate and compare the spatial conceptualization performance for sixth grade elementary school students from urban, suburban and remote schools in Taiwan. This study involved 27, 25, and 26 sixth grade students from one remote indigenous school in eastern Taiwan, one suburban indigenous school in…

8. Historic American Buildings Survey, From page 5, volume 26 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey, From page 5, volume 26 of the Castner Collection in the Print Room of the Free Library of Philadelphia, COPY OF c.1870 PHOTOGRAPH SHOWING NORTHEAST CORNER OF SIXTH AND ARCH STREETS-THE LEE HOUSE SIXTH FROM LEFT. - Robert M. Lee House & Law Office, 109-111 North Sixth Street, Philadelphia, Philadelphia County, PA

Growing Up Strong: A Mental Wellness and Life Skills Development Program for Fifth and Sixth Graders.

ERIC Educational Resources Information Center

Hammer, Judith McGowan; O'Bar, Angelina Merenda

Growing Up Strong (GUS) is a curriculum designed to develop strong mental and physical health in kindergarten through sixth grade students, with the objective of preventing subsequent substance abuse. This document contains a teacher's guide for using GUS in fifth and sixth grade classrooms (GUS 5-6) and duplication masters of materials that can…

The Effectiveness of Scaffolding Interactive Activities in Developing the English Listening Comprehension Skills of the Sixth Grade Elementary Schoolgirls in Jeddah

ERIC Educational Resources Information Center

Al-Yami, Salwa Ahmed

2008-01-01

The present study aims to investigate the effectiveness of scaffolding interactive activities in developing the English listening comprehension skills of sixth grade elementary schoolgirls in Jeddah. The subjects in this study were 50 sixth grade pupils at an elementary school in Jeddah. They were assigned to two groups--control and…

Computational Proficiency and Algorithmic Learning of Sixth-Graders Using DMP Materials: A Formative Evaluation. Technical Report No. 401.

ERIC Educational Resources Information Center

Wiles, Clyde

Two questions were investigated in this study: (1) How did the computational proficiency of sixth graders who had one year's experience with Developing Mathematical Processes (DMP) materials compare with an equivalent group of students who used the usual textbook program; and (2) What occurs when sixth graders study algorithms as sequences of rule…

Fire Safety Power. Sixth Grade. Fire Safety for Texans: Fire and Burn Prevention Curriculum Guide.

ERIC Educational Resources Information Center

Texas State Commission on Fire Protection, Austin.

This booklet comprises the sixth grade component of a series of curriculum guides on fire and burn prevention. Designed to meet the age-specific needs of sixth grade students, its objectives include: (1) developing a comprehensive understanding of fire physics, (2) evaluating electrical hazards and how to respond to those hazards, and (3)…

Investigation of the Relationship between the Spatial Visualization Success and Visual/Spatial Intelligence Capabilities of Sixth Grade Students

ERIC Educational Resources Information Center

Yenilmez, Kursat; Kakmaci, Ozlem

2015-01-01

The main aim of this research was to examine the relationship between the spatial visualization success and visual/spatial intelligence capabilities of sixth grade students. The sample of the research consists of 1011 sixth grade students who were randomly selected from the primary schools in Eskisehir. In this correlational study, data were…

The weight and use of schoolbags in New Zealand secondary schools.

PubMed

Whittfield, J K; Legg, S J; Hedderley, D I

2001-07-15

The weight and use of schoolbags amongst 140 students (70 third form students comprising 35 females and 35 males, and 70 sixth form students comprising 35 females and 35 males) from five New Zealand secondary schools was investigated. Third form students, who were smaller in stature and weight than sixth form students, were found to carry 13.2% of their body weight in schoolbags, while sixth form students carried 10.3% of their body weight. Third form students reported carrying their schoolbags for a longer period of time than sixth form students. Third form students also had less access to lockers to store their schoolbooks and supplies as only one of the five schools investigated provided lockers for third form students, whereas four of the five schools provided lockers for sixth form students. Most students used backpacks to transport their supplies, and these were predominantly carried on two shoulders. Heavy schoolbags, long carriage durations and lack of access to lockers amongst third formers, could contribute to the production or maintenance of musculoskeletal symptoms. This study suggests that third form students may be at a higher risk of developing musculoskeletal symptoms than sixth form students.

KSC-00pp1427

NASA Image and Video Library

2000-09-16

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility (OPF) bay 2 during Crew Equipment Interface Test (CEIT), Mission Specialist Joe Tanner (left) gets instruction from a worker while Mission Specialist Carlos Noriega (right) practices working latches on the Orbital Docking System in Endeavour’s payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00dig069

NASA Image and Video Library

2000-10-31

Space Shuttle Endeavour finally rests on Launch Pad 39B after its rollout was stalled several hours to fix a broken cleat on the crawler-transporter. At the far left is the Rotating Service Structure. From the Fixed Service Structure, the Orbiter Access Arm is already extended to the orbiter. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig057

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Perched atop the Mobile Launcher Platform, Space Shuttle Endeavour passes through the gate to Launch Pad 39B. To the right of the pad is a 290-foot tall water tower. To the left is the Fixed Service Structure and Rotating Service Structure. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig100

NASA Image and Video Library

2000-11-27

After their arrival at the Shuttle Landing Facility, the STS-97 crew gather to address the media. At the microphone is Mission Specialist Carlos Noriega. Behind him stand Commander Brent Jett, Pilot Michael Bloomfield and Mission Specialists Joseph Tanner and Marc Garneau, who is with the Canadian Space Agency. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00pp1633

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Removal and replacement of the cracked cleat (shoe) on the crawler-transporter (seen here with the Mobile Launcher Platform and Space Shuttle Endeavour on top) is nearly complete. The cracked cleat was noticed during rollout of Endeavour to Launch Pad 39B. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig056

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Perched atop the Mobile Launcher Platform, Space Shuttle Endeavour is nearly through the gate to Launch Pad 39B. To the right of the pad is a 290-foot tall water tower. To the left is the Fixed Service Structure and Rotating Service Structure. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00pp1753

NASA Image and Video Library

2000-11-27

At the Shuttle Landing Facility, Center Director Roy Bridges (left) greets STS-97 Commander Brent Jett on his arrival at KSC for the mission launch. At right is Mission Specialist Carlos Noriega. Jett and Noriega traveled from Johnson Space Center, Houston, Texas, in the T-38 jet aircraft behind them. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig064

NASA Image and Video Library

2000-10-31

This close-up shows the crawler-transporter’s broken cleat (center left, with a yellow ribbon around it) that caused the backward trek of Space Shuttle Endeavour from Launch Pad 39B. The Shuttle retreated to level ground so the broken cleat could be repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1753

NASA Image and Video Library

2000-11-27

At the Shuttle Landing Facility, Center Director Roy Bridges (left) greets STS-97 Commander Brent Jett on his arrival at KSC for the mission launch. At right is Mission Specialist Carlos Noriega. Jett and Noriega traveled from Johnson Space Center, Houston, Texas, in the T-38 jet aircraft behind them. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC00padig060

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Endeavour is nearly through the gate on its backward trek from Launch Pad 39B. A broken cleat on the crawler-transporter forced the reverse movement so the cleat could be repaired before moving up the incline to the top of the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00pp1759

NASA Image and Video Library

2000-11-27

After arriving at the Shuttle Landing Facility, the STS-97 crew gather to address the media. At the microphone is Mission Specialist Marc Garneau, who is with the Canadian Space Agency. Behind him can be seen Mission Specialists Joseph Tanner (left) and Carlos Noriega. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00dig068

NASA Image and Video Library

2000-10-31

Space Shuttle Endeavour finally rests on Launch Pad 39B after its rollout was stalled several hours to fix a broken cleat on the crawler-transporter. To the left is the Rotating Service Structure. The Orbiter Access Arm is already extended from the Fixed Service Structure to the orbiter. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig062

NASA Image and Video Library

2000-10-31

This close-up shows the crawler-transporter’s broken cleat (center foreground, with a yellow ribbon around it) that caused the backward trek of Space Shuttle Endeavour from Launch Pad 39B. The Shuttle retreated to level ground so the broken cleat could be repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig102

NASA Image and Video Library

2000-11-27

After their arrival at the Shuttle Landing Facility, the STS-97 crew gather to address the media. At the microphone is Mission Specialist Marc Garneau, who is with the Canadian Space Agency. Behind him stand Commander Brent Jett, Pilot Michael Bloomfield and Mission Specialists Joseph Tanner and Carlos Noriega. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC00pp1427

NASA Image and Video Library

2000-09-16

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility (OPF) bay 2 during Crew Equipment Interface Test (CEIT), Mission Specialist Joe Tanner (left) gets instruction from a worker while Mission Specialist Carlos Noriega (right) practices working latches on the Orbital Docking System in Endeavour’s payload bay. The CEIT provides an opportunity for crew members to check equipment and facilities that will be on board the orbiter during their mission. The STS-97 mission will be the sixth construction flight to the International Space Station. The payload includes a photovoltaic (PV) module, providing solar power to the Station. STS-97 is scheduled to launch Nov. 30 from KSC for the 10-day mission

KSC-00padig101

NASA Image and Video Library

2000-11-27

After their arrival at the Shuttle Landing Facility, the STS-97 crew gather to address the media. At the microphone is Mission Specialist Joseph Tanner. Behind him stand Commander Brent Jett, Pilot Michael Bloomfield and Mission Specialists Marc Garneau, who is with the Canadian Space Agency, and Carlos Noriega. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig061

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is again on level ground after its backward trek from Launch Pad 39B. A broken cleat on the crawler-transporter forced the reverse movement so the cleat could be repaired before moving up the incline to the top of the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig057

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Perched atop the Mobile Launcher Platform, Space Shuttle Endeavour passes through the gate to Launch Pad 39B. To the right of the pad is a 290-foot tall water tower. To the left is the Fixed Service Structure and Rotating Service Structure. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig099

NASA Image and Video Library

2000-11-27

After their arrival at the Shuttle Landing Facility, the STS-97 crew gather to address the media. At the microphone is Pilot Michael Bloomfield. Behind him stand Commander Brent Jett and Mission Specialists Joseph Tanner, Carolos Noriega and Marc Garneau, who is with the Canadian Space Agency. Mission STS-97is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at about 10:06 p.m. EST

KSC-00padig089

NASA Image and Video Library

2000-11-08

STS-97 Mission Specialist Joe Tanner settles into his seat in Space Shuttle Endeavour on Launch Pad 39B. He and the rest of the crew are taking part in a simulated launch countdown, part of Terminal Countdown Demonstration Test activities that also include emergency egress training and familiarization with the payload. Mission STS-97 is the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections. STS-97 is scheduled to launch Nov. 30 at 10:05 p.m. EST

KSC00pp1633

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Removal and replacement of the cracked cleat (shoe) on the crawler-transporter (seen here with the Mobile Launcher Platform and Space Shuttle Endeavour on top) is nearly complete. The cracked cleat was noticed during rollout of Endeavour to Launch Pad 39B. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig056

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Perched atop the Mobile Launcher Platform, Space Shuttle Endeavour is nearly through the gate to Launch Pad 39B. To the right of the pad is a 290-foot tall water tower. To the left is the Fixed Service Structure and Rotating Service Structure. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC00padig061

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour is again on level ground after its backward trek from Launch Pad 39B. A broken cleat on the crawler-transporter forced the reverse movement so the cleat could be repaired before moving up the incline to the top of the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

KSC-00padig060

NASA Image and Video Library

2000-10-31

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Endeavour is nearly through the gate on its backward trek from Launch Pad 39B. A broken cleat on the crawler-transporter forced the reverse movement so the cleat could be repaired before moving up the incline to the top of the pad. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections

Congressman Dave Weldon enjoys viewing the STS-97 launch

NASA Technical Reports Server (NTRS)

2000-01-01

Florida Congressman Dave Weldon enjoys the on-time launch of Space Shuttle Endeavour on the sixth construction flight to the International Space Station. Weldon and other guests of NASA viewed the launch from the Banana Creek VIP viewing site. Liftoff of Endeavour occurred at 10:06:01 p.m. EST. Endeavour is transporting the P6 Integrated Truss Structure that comprises Solar Array Wing-3 and the Integrated Electronic Assembly, to provide power to the Space Station. The 11-day mission includes two spacewalks to complete the solar array connections. Endeavour is expected to land Dec. 11 at 6:19 p.m. EST.

Solar heating and cooling system design and development

NASA Technical Reports Server (NTRS)

1978-01-01

The progress of the program during the sixth program quarter is reported. The program calls for the development and delivery of eight prototype solar heating and cooling systems for installation and operational test. The William O'Brien single-family heating system was installed and is operational. The New Castle single-family heating residence is under construction. The Kansas University (KU) system is in the final design stages. The 25 ton cooling subsystem for KU is the debugging stage. Pressure drops that were greater than anticipated were encountered. The 3 ton simulation work is being finalized and the design parameters for the Rankine system were determined from simulation output.

A closeup of the broken cleat on the crawler-transporter

NASA Technical Reports Server (NTRS)

2000-01-01

This closeup shows the crawler-transporter's broken cleat (center foreground, with a yellow ribbon around it) that caused the backward trek of Space Shuttle Endeavour from Launch Pad 39B. The Shuttle retreated to level ground so the broken cleat could be repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections.

A closeup of the broken cleat on the crawler-transporter

NASA Technical Reports Server (NTRS)

2000-01-01

This closeup shows the crawler-transporter's broken cleat (center left, with a yellow ribbon around it) that caused the backward trek of Space Shuttle Endeavour from Launch Pad 39B. The Shuttle retreated to level ground so the broken cleat could be repaired. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections.

General design, construction, and operation guidelines: Constructed wetlands wastewater treatment systems for small users including individual residences. Second edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steiner, G.R.; Watson, J.T.

1993-05-01

One of the Tennessee Valley Authority`s (TVA`s) major goals is cleanup and protection of the waters of the Tennessee River system. Although great strides have been made, point source and nonpoint source pollution still affect the surface water and groundwater quality in the Tennessee Valley and nationally. Causes of this pollution are poorly operating wastewater treatment systems or the lack of them. Practical solutions are needed, and there is great interest and desire to abate water pollution with effective, simple, reliable and affordable wastewater treatment processes. In recognition of this need, TVA began demonstration of the constructed wetlands technology inmore » 1986 as an alternative to conventional, mechanical processes, especially for small communities. Constructed wetlands can be downsized from municipal systems to small systems, such as for schools, camps and even individual homes.« less

Water-Quality Monitoring and Studies of the Formation and Fate of Trihalomethanes During the Third Injection, Storage, and Recovery Test at Lancaster, Antelope Valley, California, March 1998 Through April 1999

DTIC Science & Technology

2002-01-01

during preparation of this report, and reviews by Darnella Murphy, Greg Mendez , Rick Iwatsubo, and Peter Martin contributed immensely to this work...Mary Gibson and Carol Sanchez edited the report, and Cathy Munday constructed figure 1. WATER-QUALITY MONITORING AT WELLS Water samples were

SOLCOST. Solar Hot Water Handbook. A Simplified Design Method for Sizing and Costing Residential and Commercial Solar Service Hot Water Systems. Second Edition.

ERIC Educational Resources Information Center

Energy Research and Development Administration, Washington, DC. Div. of Solar Energy.

This pamphlet offers a preview of information services available from Solcost, a research and development project. The first section explains that Solcost calculates system and costs performance for solar heated and cooled new and retrofit constructions, such as residential buildings and single zone commercial buildings. For a typical analysis,…

A Call for National Security System Transformation

DTIC Science & Technology

2012-06-01

Gabriel Marcella . Carlisle, PA: Strategic Studies Institute, U.S. Army War College, 2008. Fox News Corporation. “Last American Troops Leave Iraq...by Gabriel Marcella . Carlisle, PA: Strategic Studies Institute, U.S. Army War College, 2008. Stewart, Douglas. “Constructing the Iron Cage: The...1947 National Security Act.” In Affairs of State: The Interagency and National Security. Edited by Gabriel Marcella . Carlisle, PA: Strategic

Fundamental CRISPR-Cas9 tools and current applications in microbial systems.

PubMed

Tian, Pingfang; Wang, Jia; Shen, Xiaolin; Rey, Justin Forrest; Yuan, Qipeng; Yan, Yajun

2017-09-01

Derived from the bacterial adaptive immune system, CRISPR technology has revolutionized conventional genetic engineering methods and unprecedentedly facilitated strain engineering. In this review, we outline the fundamental CRISPR tools that have been employed for strain optimization. These tools include CRISPR editing, CRISPR interference, CRISPR activation and protein imaging. To further characterize the CRISPR technology, we present current applications of these tools in microbial systems, including model- and non-model industrial microorganisms. Specially, we point out the major challenges of the CRISPR tools when utilized for multiplex genome editing and sophisticated expression regulation. To address these challenges, we came up with strategies that place emphasis on the amelioration of DNA repair efficiency through CRISPR-Cas9-assisted recombineering. Lastly, multiple promising research directions were proposed, mainly focusing on CRISPR-based construction of microbial ecosystems toward high production of desired chemicals.

Opportunities and Challenges for the Emerging Field of Positive Emotion Regulation: A Commentary on the Special Edition on Positive Emotions and Cognitions in Clinical Psychology.

PubMed

Dunn, Barnaby D

2017-01-01

The importance of developing a better understanding of positive emotion regulation in both healthy and clinical populations is now recognised. This special edition brings together leading figures in the positive emotion regulation field and has contributions characterizing positive phenomena, differentiating them from negative phenomena, and evaluating underlying psychological mechanisms that drive these phenomena. This commentary reviews these articles to highlight challenges and opportunities for this emerging field, including the need to better characterize positive phenomena, to be more explicit about how the links between negative and positive phenomena are conceptualised, to evaluate more robustly underlying mechanisms, to standardize measurement of positive constructs, and to ensure that these scientific findings lead to meaningful changes in real-world policy and practice.