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Sample records for construction sixth edition

  1. Aerospace Bibliography. Sixth Edition.

    ERIC Educational Resources Information Center

    National Aerospace Education Council, Washington, DC.

    This sixth edition of the National Aeronautics and Space Administration's (NASA) bibliography presents an updated list of books, references, periodicals, and other educational materials related to space flight and space science. To find materials on a particular subject and for a specific reading level, users are advised to refer first to Part…

  2. Teachers and the Law. Sixth Edition.

    ERIC Educational Resources Information Center

    Fischer, Louis; Schimmel, David; Stellman, Leslie

    This book is about teachers and the laws that affect them. New to this sixth edition are new court cases and a chapter that highlights likely controversies in the coming years, including school choice, high-stakes testing, control of the Internet, and gang clothing. The book is divided into two parts. Part I, "The Legal Aspects of Teaching,"…

  3. [The meaning of the sixth edition of "Organon der Heilkunst"].

    PubMed

    Schmidt, Josef M

    2002-01-01

    Like any artist, the paractitioner of the healing art should exactly know his tools, i.e. his medicines and the directions for their application. In addition, he should be able to rely on their genuineness. Regarding the tool "Organon", considerable uncertainty has been expressed by some physicians about the authenticity of Hahnemann's instructions for preparing and applying Q-potencies, as described in the sixth edition of the Organon of Medicine published by Richard Haehl in 1921. Since 1992, however, the first text-critical edition of the sixth edition of the Organonis available. Unlike Haehl's edition this one is exclusively based on Hahnemann's original manuscript and precisely transcribing all its handwriting, vouches for its authenticity. Hence there is no reason left to ignore Hahnemanns instructions concerning Q-potencies. This paper presents the history of the reception of Q-potencies as well as their prerequisites and evolution up to Hahnemann's final modifications of his earlier directions. As it turns out, these late instructions of Hahnemann do not mean complete change of all his previous opinions. Rather they are the logical completion of a course followed by him for ten years already. Q-potencies were Hahnemann's solution of the following therapeutic dilemma: on the one side physicians are inclined to repeat the dose of a high potency as often as possible in order to accelerate the process of healing; on the other side they should refrain from repeating the dose to avoid violent aggravations of the state of the patient.

  4. American College of Physicians Ethics Manual: sixth edition.

    PubMed

    Snyder, Lois

    2012-01-03

    Medicine, law, and social values are not static. Reexamining the ethical tenets of medicine and their application in new circumstances is a necessary exercise. The sixth edition of the American College of Physicians (ACP) Ethics Manual covers emerging issues in medical ethics and revisits older ones that are still very pertinent. It reflects on many of the ethical tensions in medicine and attempts to shed light on how existing principles extend to emerging concerns. In addition, by reiterating ethical principles that have provided guidance in resolving past ethical problems, the Manual may help physicians avert future problems. The Manual is not a substitute for the experience and integrity of individual physicians, but it may serve as a reminder of the shared duties of the medical profession.

  5. Test Scores and What They Mean. Sixth Edition.

    ERIC Educational Resources Information Center

    Lyman, Howard B.

    The first edition of this book was written to give information about testing to people whose work gave them access to test results, but whose training included little or nothing about the use and interpretation of tests. Later editions have been intended for a broader audience as the need for understanding what test scores really mean has…

  6. How to Conduct Surveys: A Step-by-Step Guide. Sixth Edition

    ERIC Educational Resources Information Center

    Fink, Arlene

    2016-01-01

    Packed with new topics that reflect today's challenges, the Sixth Edition of the bestselling "How to Conduct Surveys" guides readers through the process of developing their own rigorous surveys and evaluating the credibility and transparency of surveys created by others. Offering practical, step-by-step advice and written in the same…

  7. Educators Guide to Free Films. Thirty-Sixth Edition.

    ERIC Educational Resources Information Center

    Horkheimer, Mary Foley, Comp.; Diffor, John C., Comp.

    This edition lists more than 4000 films available free of cost throughout the United States generally, with those available in Australia and Canada indicated separately. Listings are organized according to curriculum categories. Each listing includes title, description of the contents, date of release, size, whether sound or silent, running time,…

  8. Biological Science: An Ecological Approach. BSCS Green Version. Teacher's Edition. Sixth Edition.

    ERIC Educational Resources Information Center

    Biological Sciences Curriculum Study, Colorado Springs.

    This book is the teacher's edition to the 1987 edition of the Biological Sciences Curriculum Study Green Version textbook. It contains directions for teaching with this version, a description of the accompanying materials, teaching strategies by chapters, lists of useful software, safety guidelines, a materials list, chemical safety information,…

  9. The Impact of Fast ForWord[R] on Sixth Grade Students' Use of Standard Edited American English

    ERIC Educational Resources Information Center

    Rogowsky, Beth A.

    2010-01-01

    This study investigated the impact of Fast ForWord[R] products, specifically Fast ForWord[R] Literacy (FFL) and Fast ForWord[R] Reading Level 2 (FFR2), on sixth grade students' use of Standard Edited American English (SEAE). Fast ForWord[R] is a computer-based program that focuses on phonological awareness and makes use of modeled…

  10. What We Can Learn from the Sixth Edition of "The American Community College": CSCC Awards Luncheon Address

    ERIC Educational Resources Information Center

    Kisker, Carrie B.

    2015-01-01

    This speech, given at the 2014 Council for the Study of Community Colleges annual Awards Luncheon, describes three of the major changes in the sixth edition of "The American Community College". The speech also describes what those changes can tell us about the directions in which our colleges are moving and the ways in which community…

  11. Experiences in Language: Tools and Techniques for Language Arts Methods. Sixth Edition.

    ERIC Educational Resources Information Center

    Petty, Walter T.; And Others

    Continuing an emphasis from earlier editions on such areas as early education and the use of electronic teaching aids as an integral aspect of the classroom program, this book views language arts instruction as based on a comprehensive instruction plan composed of many different teaching strategies and types of materials. This edition of the book…

  12. Evaluation of the DIBELS (Sixth Edition) Diagnostic System for the Selection of Native and Proficient English Speakers at Risk of Reading Difficulties

    ERIC Educational Resources Information Center

    Smolkowski, Keith; Cummings, Kelli D.

    2016-01-01

    This comprehensive evaluation of the Dynamic Indicators of Basic Early Literacy Skills Sixth Edition (DIBELS6) set of measures gives a practical illustration of signal detection methods, the methods used to determine the value of screening and diagnostic systems, and offers an updated set of cut scores (decision thresholds). Data were drawn from a…

  13. Your Reading: A Booklist for Junior High and Middle School Students. Sixth Edition.

    ERIC Educational Resources Information Center

    Christensen, Jane, Ed.

    With many annotations written or edited by students, this booklist contains 3,100 citations of fiction and nonfiction publications for adolescents. Most entries were published within the past few years, although well-written older books are also included. The annotations, which include appropriate age ranges, are categorized as follows:…

  14. Introduction to United States Government Information Sources. Sixth Edition. Library and Information Science Text Series.

    ERIC Educational Resources Information Center

    Morehead, Joe

    This book provides an account of the general and specialized sources, in print and non-print formats, that make up the bibliographic and textual structure of federal government information. This edition has been revised to reflect the many changes that have occurred in the production and dissemination of government products within the last five…

  15. Educators Guide to Free Health, Physical Education and Recreation Materials; A Multimedia Guide. Sixth Annual Edition.

    ERIC Educational Resources Information Center

    Horkheimer, Foley A.; Alley, Louis E.

    The guide lists 2,955 free items, of which 1,336 are new in this edition, relevant to health, physical education, and recreation. Each item is listed under one of the categories, and is provided with information about type of medium, specifications of the product, a brief description of the product, and its cost and distributor. A title index, a…

  16. Guidelines for the Administration and Accreditation of the Standardized Craft Training Process. Sixth Edition.

    ERIC Educational Resources Information Center

    National Center for Construction Education and Research, Gainesville, FL.

    This document contains guidelines for the administration and accreditation of the standardized craft training process that was developed by the National Center for Construction Education and Research (NCCER) in partnership with various sectors of the construction and maintenance industries. The following are among the topics discussed in Chapters…

  17. Power Product Equipment Technician: Construction Equipment. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    The instructor's guide in this package, which is one in a series of new publications developed to replace the Multistate Academic and Vocational Curriculum Consortium's previous small-engine curricula, contains the materials required to teach a competency-based course in repairing construction equipment. The guide begins with an introduction…

  18. Raising voices: How sixth graders construct authority and knowledge in argumentative essays

    NASA Astrophysics Data System (ADS)

    Monahan, Mary Elizabeth

    This qualitative classroom-based study documents one teacher-researcher's response to the "voice" debate in composition studies and to the opposing views expressed by Elbow and Bartholomae. The author uses Bakhtin's principle of dialogism, Hymes's theory of communicative competence, as well as Ivanic's discussion of discoursally constructed identities to reconceptualize voice and to redesign writing instruction in her sixth grade classroom. This study shows how students, by redefining and then acting on that voice pedagogy in terms that made sense to them, shaped the author's understanding of what counts as "voiced" writing in non-narrative discourse. Based on a grounded-theory analysis of the twenty-six sixth graders' argumentative essays in science, the author explains voice, not as a property of writers or of texts, but as a process of "knowing together"---a collaborative, but not entirely congenial, exercise of establishing one's authority by talking with, against, and through other voices on the issue. As the results of this study show, the students' "I-Ness" or authorial presence within their texts, was born in a nexus of relationships with "rivals," "allies" and "readers." Given their teacher's injunctions to project confidence and authority in argumentative writing, the students assumed fairly adversarial stances toward these conversational partners throughout their essays. Exaggerating the terms for voiced writing built into the curriculum, the sixth graders produced essays that read more like caricatures than examples of argumentation. Their displays of rhetorical bravado and intellectual aggressiveness, however offsetting to the reader, still enabled these sixth graders to composed voiced essays. This study raises doubts about the value of urging students to sound like their "true selves" or to adopt the formal registers of academe. Students, it seems clear, stand to gain by experimenting with a range of textual identities. The author suggests that voice

  19. Children & Books. Sixth Edition.

    ERIC Educational Resources Information Center

    Sutherland, Zena; And Others

    Designed for classes in children's literature in English and education departments and in library schools, the emphases in this book are on understanding children and their needs, on perspectives and background, on criteria and types of literature, and on artists and authors. The first part provides an overview of children's needs and interests,…

  20. Guidelines for structural bolting in accordance with the AISC (American Institute of Steel Construction) eighth edition manual of steel construction''

    SciTech Connect

    Western, J.L.; Johns, D.M.

    1990-05-11

    This paper specifies the usage of structural bolts in terms of their design, selection and application, in accordance with the American Institute of Steel Construction (AISC) Eighth Edition. Manual of Steel Construction.'' 1 tab.

  1. Construct Validity of Selected Measures of Physical Activity Beliefs and Motives in Fifth and Sixth Grade Boys and Girls

    PubMed Central

    Saunders, Ruth P.; McIver, Kerry L.; Dowda, Marsha; Pate, Russell R.

    2013-01-01

    Objective Scales used to measure selected social-cognitive beliefs and motives for physical activity were tested among boys and girls. Methods Covariance modeling was applied to responses obtained from large multi-ethnic samples of students in the fifth and sixth grades. Results Theoretically and statistically sound models were developed, supporting the factorial validity of the scales in all groups. Multi-group longitudinal invariance was confirmed between boys and girls, overweight and normal weight students, and non-Hispanic black and white children. The construct validity of the scales was supported by hypothesized convergent and discriminant relationships within a measurement model that included correlations with physical activity (MET • min/day) measured by an accelerometer. Conclusions Scores from the scales provide valid assessments of selected beliefs and motives that are putative mediators of change in physical activity among boys and girls, as they begin the understudied transition from the fifth grade into middle school, when physical activity naturally declines. PMID:23459310

  2. Airfield construction (3rd revised and enlarged edition)

    NASA Astrophysics Data System (ADS)

    Goretskii, Leonid I.; Boguslavskii, Adol'f. M.; Serebrenikov, Vadim A.; Barzdo, V. I.; Leshchitskaia, T. P.; Polosin-Nikitin, S. M.

    The principal engineering aspects of airfield construction are discussed. In particular, attention is given to the fundamental principles and organizational aspects of airfield construction; excavation work and airfield layout; construction of drainage systems; foundations and pavements; and quality control and safety engineering. The discussion also covers the operation of various support plants, including concrete production and mixing, production of asphalt-concrete mixtures and organic binders, production of structural steel and reinforced concrete components, and operation of stone quarries and gravel pits.

  3. Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan

    ERIC Educational Resources Information Center

    Des Jardin, Molly Catherine

    2012-01-01

    "Editing Identity: Literary Anthologies and the Construction of the Author in Meiji Japan" problematizes widespread acceptance of anthologies of authors' "complete works" as both transparent and authoritative compendia of Japanese literature. In the Meiji period (1868-1912), they enjoyed a sudden boom in popularity and have…

  4. Introduction to Drywall. Instructor Edition. Introduction to Construction Series.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide contains the materials required to teach a competency-based introductory course in drywalling to students who have chosen to explore careers in construction. It contains three units: drywall materials, drywall tools, and applied skills. Each instructional unit includes some or all of the basic components of a unit of…

  5. Introduction to Drywall. Introduction to Construction Series. Instructor Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This competency-based curriculum guide on the specialty area of drywall is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in mind.…

  6. Introduction to Sheet Metal. Instructor Edition. Introduction to Construction Series.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide contains the materials required to teach a competency-based introductory course in sheet metal work to students who have chosen to explore careers in construction. The following topics are covered in the course's three instructional units: sheet metal materials, sheet metal tools, and applied skills. Each unit contains some…

  7. Introduction to Insulation. Instructor Edition. Introduction to Construction Series.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide contains the materials required to teach a competency-based introductory course in insulation to students who have chosen to explore careers in construction. It contains three units: instructional unit includes some or all of the basic components of a unit of instruction: performance objectives, suggested activities for the…

  8. A Model Framework for Course Materials Construction. Third Edition.

    ERIC Educational Resources Information Center

    Schlenker, Richard M.

    A model framework for course materials construction is presented as an aid to Coast Guard course writers and coordinators, curriculum developers, and instructors who must modify a course or draft a new one. The model assumes that the instructor or other designated person has: (1) completed a task analysis which identifies the competencies, skills…

  9. Energy considerations for hospital construction and equipment, 1984 edition

    SciTech Connect

    Not Available

    1984-07-01

    The intent of this document is to promote energy conservation without reducing indoor environmental quality below the acceptable levels set forth in Guidelines for Construction and Equipment of Hospital and Medical Facilities. The Guidelines currently describe acceptable performances that are considered minimums and direct the designer to conserve energy to the extent practical. This companion document provides guidance on conservation measures. Specifically, it provides general directions for: Technical Feasibility--implications of design solutions; Life Cycle Cost Procedures--economic justification for systems and procedures; Operational Manageability--assuring quality performance during the lifetime of the building. By using the Guidelines as the basis, this guidance allows for maximum freedom of design and flexibility within which the designer, architect, engineer, and administrative staff can work together in a unified design process to resolve special problems.

  10. A simple Gateway-assisted construction system of TALEN genes for plant genome editing

    PubMed Central

    Kusano, Hiroaki; Onodera, Hitomi; Kihira, Miho; Aoki, Hiromi; Matsuzaki, Hikaru; Shimada, Hiroaki

    2016-01-01

    TALEN is an artificial nuclease being applied for sequence-specific genome editing. For the plant genome editing, a pair of TALEN genes is expressed in the cells, and a binary plasmid for Agrobacterium-mediated transformation should be assembled. We developed a novel procedure using the Gateway-assisted plasmids, named Emerald–Gateway TALEN system. We constructed entry vectors, pPlat plasmids, for construction of a desired TALEN gene using Platinum Gate TALEN kit. We also created destination plasmid, pDual35SGw1301, which allowed two TALEN genes to both DNA strands to recruit using Gateway technology. Resultant TALEN genes were evaluated by the single-strand annealing (SSA) assay in E. coli cells. By this assay, the TALENs recognized the corresponding targets in the divided luciferase gene, and induced a specific recombination to generate an active luciferase gene. Using the TALEN genes constructed, we created a transformant potato cells in which a site-specific mutation occurred at the target site of the GBSS gene. This suggested that our system worked effectively and was applicable as a convenient tool for the plant genome editing. PMID:27452606

  11. A simple Gateway-assisted construction system of TALEN genes for plant genome editing.

    PubMed

    Kusano, Hiroaki; Onodera, Hitomi; Kihira, Miho; Aoki, Hiromi; Matsuzaki, Hikaru; Shimada, Hiroaki

    2016-07-25

    TALEN is an artificial nuclease being applied for sequence-specific genome editing. For the plant genome editing, a pair of TALEN genes is expressed in the cells, and a binary plasmid for Agrobacterium-mediated transformation should be assembled. We developed a novel procedure using the Gateway-assisted plasmids, named Emerald-Gateway TALEN system. We constructed entry vectors, pPlat plasmids, for construction of a desired TALEN gene using Platinum Gate TALEN kit. We also created destination plasmid, pDual35SGw1301, which allowed two TALEN genes to both DNA strands to recruit using Gateway technology. Resultant TALEN genes were evaluated by the single-strand annealing (SSA) assay in E. coli cells. By this assay, the TALENs recognized the corresponding targets in the divided luciferase gene, and induced a specific recombination to generate an active luciferase gene. Using the TALEN genes constructed, we created a transformant potato cells in which a site-specific mutation occurred at the target site of the GBSS gene. This suggested that our system worked effectively and was applicable as a convenient tool for the plant genome editing.

  12. High‑efficiency system for construction and evaluation of customized TALENs for silkworm genome editing.

    PubMed

    Wang, Feng; Ma, Sanyuan; Xu, Hanfu; Duan, Jianping; Wang, Yuancheng; Ding, Huan; Liu, Yuanyuan; Wang, Xiaogang; Zhao, Ping; Xia, Qingyou

    2013-12-01

    Transcription activator-like effector nuclease (TALEN) possesses the characteristics of ease design and precise DNA targeting. In the silkworm Bombyx mori, TALEN has been successfully used to knockout an endogenous Bombyx gene, and shown the huge potential in functional genes research and improvement of the economical characteristics of silkworm. Thus, there is an urgent need to develop an applicable system that permits the efficient construction of customized TALEN with high activity that could efficiently induce the hereditable mutagenesis in the silkworm. In this study, we constructed an efficient assembly and evaluation system of the customized TALEN especiallly for silkworm genome editing by combination of a modified Golden Gate ligation strategy, a luciferase (LUC) reporter system in insect cell culture for binding activity and a surveyor nuclease assay system in silkworm embryos for cleavage efficiency. We showed the reliability of this system by assembling a pair of TALENs targeting a silkworm genome locus and assaying their binding and cleavage activities. The assembly strategy was convenient and efficient which allows the rapid construction of customized TALEN in less than 1 week, and the evaluation system was reliable and necessary for screening of the customized TALEN pair with high binding and cleavage activities. The results showed this system is a reliable and efficient tool for the construction of customized TALEN with high activity for gene targeting of silkworm, and will contribute to the wide application of TALEN technology in the functional gene research of silkworm.

  13. Program Demand Cost Model for Alaskan Schools. 6th Edition. Revised.

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau.

    The Program Demand Cost Model for Alaskan Schools (Cost Model) is a tool for use by school districts and their consultants in estimating school construction costs in the planning phase of a project. This document sets out the sixth edition of the demand-cost model, a rewrite of the whole system. The model can be used to establish a complete budget…

  14. Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

    PubMed

    Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

    2011-03-01

    Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

  15. The School and Community Relations. Sixth Edition.

    ERIC Educational Resources Information Center

    Gallagher, Donald R.; Bagin, Don; Kindred, Leslie W.

    Ways in which educators can communicate well, and subsequently gain support for programs, curriculum, and discipline, are presented. The book is divided into four parts: "Essential Considerations,""Relations with Special Publics,""Communication Tools," and "Evaluation." In part 1, some of the topics discussed include the importance of public…

  16. United States Air Force Summary, Sixth Edition

    DTIC Science & Technology

    1980-04-01

    AGE MDS 0-2 1=.2. 6-8 -.2=11. 12-14 l2.:l1. 18-20 21- 23 24+ NUMBER YRS/MOS A-7 9 68 11 88 7/1 A-lO 198 14 212 1/ 5 A-37 1 2 1 4 7/8 B-1 1 2 1/7. B-52 58...211 80 349 19/10 FB-111 42 24 66 8/11 C- 5 2 60 15 77 8/0 C-6 1 13/10 C-9 3 9 11 23 8/6 C-12 4 11 15 3/ 5 C-130 10 61 26 43 86 135 8 2 371 12/0 C-131 1...1,363 10/6 F- 5 8 78 20 106 4/1 F-15 319 105 4 428 2/1 F-16 49 1 50 0/8 F-101 20 20 19/8 F-105 22 23 15/4 F-106 126 19 145 19/8 F-111 22 192 149 364 8

  17. Specifications and Construction Methods for Asphalt Concrete and Other Plant-Mix Types, 3rd Edition.

    ERIC Educational Resources Information Center

    Asphalt Inst., College Park, MD.

    The purpose of this publication is to assist engineers in the analysis, design and control of paving projects that use asphalt concrete and other asphalt plant-mixes. The scope of this new third edition has been enlarged, and changes necessitated by advances in asphalt technology have been incorporated. Chapters I and II and Appendices A and B…

  18. Construct Validity Evidence for Bracken School Readiness Assessment, Third Edition, Spanish Form Scores

    ERIC Educational Resources Information Center

    Ortiz, Arlene; Clinton, Amanda; Schaefer, Barbara A.

    2015-01-01

    Convergent and discriminant validity evidence was examined for scores on the Spanish Record Form of the Bracken School Readiness Assessment, Third Edition (BSRA-3). Participants included a sample of 68 Hispanic, Spanish-speaking children ages 4 to 5 years enrolled in preschool programs in Puerto Rico. Scores obtained from the BSRA-3 Spanish Record…

  19. Sixth Form Examining Methods.

    ERIC Educational Resources Information Center

    Schools Council, London (England).

    The methods of examining in the sixth form of secondary education in England and Wales is the basis for discussion by subject committees of the Schools Council. Special reference is made to internal examinations, oral assessments, teacher's assessments, the relaxing of the time limits for examination, and the use of aids during examinations. The…

  20. Computational methods for the construction, editing, and error correction of DNA molecules and their libraries.

    PubMed

    Raz, Ofir; Ben Yehezkel, Tuval

    2015-01-01

    The field of synthetic biology is fueled by steady advances in our ability to produce designer genetic material on demand. This relatively new technological capability stems from advancements in DNA construction biochemistry as well as supporting computational technologies such as tools for specifying large DNA libraries, as well as planning and optimizing their actual physical construction. In particular, the design, planning, and construction of user specified, combinatorial DNA libraries are of increasing interest. Here we present some of the computational tools we have built over the past decade to support the multidisciplinary task of constructing DNA molecules and their libraries. These technologies encompass computational methods for [1] planning and optimizing the construction of DNA molecules and libraries, [2] the utilization of existing natural or synthetic fragments, [3] identification of shared fragments, [4] planning primers and overlaps, [5] minimizing the number of assembly steps required, and (6) correcting erroneous constructs. Other computational technologies that are important in the overall process of DNA construction, such as [1] computational tools for efficient specification and intuitive visualization of large DNA libraries (which aid in debugging library design pre-construction) and [2] automated liquid handling robotic programming [Linshiz et al., Mol Syst Biol 4:191, 2008; Shabi et al., Syst Synth Biol 4:227-236, 2010], which aid in the construction process itself, have been omitted due to length limitations.

  1. [Application of CRISPR-Cas9 genome editing for constructing animal models of human diseases].

    PubMed

    Ou, Zhanhui; Sun, Xiaofang

    2016-08-01

    The CRISPR-Cas9 system is a new targeted nuclease for genome editing, which can directly introduce modifications at the targeted genomic locus. The system utilizes a short single guide RNA (sgRNA) to direct the endonuclease Cas9 in the genome. Upon targeting, Cas9 can generate DNA double-strand breaks (DSBs). As such DSBs are repaired by non-homologous end joining (NHEJ) or homology directed repair (HDR), therefore facilitates introduction of random or specific mutations, repair of endogenous mutations, or insertion of DNA elements. The system has been successfully used to generate gene targeted cell lines including those of human, animals and plants. This article reviews recent advances made in this rapidly evolving technique for the generation of animal models for human diseases.

  2. Sixth Graders' Co-construction of Explanations of a Disturbance in an Ecosystem: Exploring relationships between grouping, reflective scaffolding, and evidence-based explanations

    NASA Astrophysics Data System (ADS)

    Kyza, Eleni A.; Constantinou, Costas P.; Spanoudis, George

    2011-12-01

    We report on a study investigating the relationship between cognitive ability grouping, reflective inquiry scaffolding, and students' collaborative explanations of an ecosystem disturbance which took place when a number of flamingo birds died in a salt lake because of nearby intensive human activities. Twenty-six pairs of students from two intact sixth-grade classes participated in the study. All students investigated scientific data relating to the ecosystem problem using a web-based learning environment. One class was provided with web-based reflective inquiry scaffolding (WorkSpace), while the other class used PowerPoint. The main data analyzed for this study consisted of each pair's written explanation and task-related artifacts. Findings show that the web-based reflective scaffolding supported students in providing valid evidence in support of their explanations. The analyses of the students' collaborative explanations showed no statistically significant differences that could be attributed to prior achievement between students in the WorkSpace condition, while differences were found between the different cognitive ability pairs in the PowerPoint class. These findings suggest that the WorkSpace scaffolding may have provided more influential support to lower cognitive ability pairs in creating evidence-based explanations.

  3. Academic Bias in Language Testing: A Construct Validity Critique of the IPT I Oral Grades K-6 Spanish Second Edition (IPT Spanish)

    ERIC Educational Resources Information Center

    MacSwan, Jeff; Mahoney, Kate

    2008-01-01

    Construct validity concerns for the IPT I Oral Grades K-6 Spanish Second Edition (IPT-S) as a measure of native oral language proficiency are examined. The examination included describing a subset of items that contributes most to overall score and native-language proficiency designation. Correlations between this subset of items and the overall…

  4. VisANT 3.0: new modules for pathway visualization, editing, prediction and construction.

    PubMed

    Hu, Zhenjun; Ng, David M; Yamada, Takuji; Chen, Chunnuan; Kawashima, Shuichi; Mellor, Joe; Linghu, Bolan; Kanehisa, Minoru; Stuart, Joshua M; DeLisi, Charles

    2007-07-01

    With the integration of the KEGG and Predictome databases as well as two search engines for coexpressed genes/proteins using data sets obtained from the Stanford Microarray Database (SMD) and Gene Expression Omnibus (GEO) database, VisANT 3.0 supports exploratory pathway analysis, which includes multi-scale visualization of multiple pathways, editing and annotating pathways using a KEGG compatible visual notation and visualization of expression data in the context of pathways. Expression levels are represented either by color intensity or by nodes with an embedded expression profile. Multiple experiments can be navigated or animated. Known KEGG pathways can be enriched by querying either coexpressed components of known pathway members or proteins with known physical interactions. Predicted pathways for genes/proteins with unknown functions can be inferred from coexpression or physical interaction data. Pathways produced in VisANT can be saved as computer-readable XML format (VisML), graphic images or high-resolution Scalable Vector Graphics (SVG). Pathways in the format of VisML can be securely shared within an interested group or published online using a simple Web link. VisANT is freely available at http://visant.bu.edu.

  5. Understanding Physics, First Edition

    NASA Astrophysics Data System (ADS)

    Cummings, Karen; Laws, Priscilla W.; Redish, Edward F.; Cooney, Patrick J.

    2004-03-01

    Built on the foundations of Halliday, Resnick, and Walker's Fundamentals of Physics Sixth Edition, this text is designed to work with interactive learning strategies that are increasingly being used in physics instruction (for example, microcomputer-based labs, interactive lectures, etc. ). In doing so, it incorporates new approaches based upon Physics Education Research (PER), aligns with courses that use computer-based laboratory tools, and promotes Activity Based Physics in lectures, labs, and recitations.

  6. Introduction to Heating, Ventilation and Air Conditioning (HVAC). Instructor Edition. Introduction to Construction Series.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide contains the materials required to teach a competency-based introductory course in heating, ventilating, and air conditioning (HVAC) to students who have chosen to explore careers in construction. It contains three units: HVAC materials, HVAC tools, and applied skills. Each instructional unit includes some or all of the…

  7. Construction Occupations--Finishing. Reprinted from the Occupational Outlook Handbook, 1978-79 Edition.

    ERIC Educational Resources Information Center

    Bureau of Labor Statistics (DOL), Washington, DC.

    Focusing on finishing construction occupations, this document is one in a series of forty-one reprints from the Occupational Outlook Handbook providing current information and employment projections for individual occupations and industries through 1985. The specific occupations covered in this document include air…

  8. Understanding and producing the reduced relative construction: Evidence from ratings, editing and corpora

    PubMed Central

    Hare, Mary; Tanenhaus, Michael K.; McRae, Ken

    2011-01-01

    Tworating studies demonstrate that English speakers willingly produce reduced relatives with internal cause verbs (e.g., Whisky fermented in oak barrels can have a woody taste), and judge their acceptability based on factors known to influence ambiguity resolution, rather than on the internal/external cause distinction. Regression analyses demonstrate that frequency of passive usage predicts reduced relative frequency in corpora, but internal/external cause status does not. The authors conclude that reduced relatives with internal cause verbs are rare because few of these verbs occur in the passive. This contrasts with the claim in McKoon and Ratcliff (McKoon, G., & Ratcliff, R. (2003). Meaning through syntax: Language comprehension and the reduced relative clause construction. Psychological Review, 110, 490–525) that reduced relatives like The horse raced past the barn fell are rare and, when they occur, incomprehensible, because the meaning of the reduced relative construction prohibits the use of a verb with an internal cause event template. PMID:22162904

  9. Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing.

    PubMed

    Fukuda, Masatora; Umeno, Hiromitsu; Nose, Kanako; Nishitarumizu, Azusa; Noguchi, Ryoma; Nakagawa, Hiroyuki

    2017-02-02

    As an alternative to DNA mutagenesis, RNA mutagenesis can potentially become a powerful gene-regulation method for fundamental research and applied life sciences. Adenosine-to-inosine (A-to-I) RNA editing alters genetic information at the transcript level and is an important biological process that is commonly conserved in metazoans. Therefore, a versatile RNA-mutagenesis method can be achieved by utilising the intracellular RNA-editing mechanism. Here, we report novel guide RNAs capable of inducing A-to-I mutations by guiding the editing enzyme, human adenosine deaminase acting on RNA (ADAR). These guide RNAs successfully introduced A-to-I mutations into the target-site, which was determined by the reprogrammable antisense region. In ADAR2-over expressing cells, site-directed RNA editing could also be performed by simply introducing the guide RNA. Our guide RNA framework provides basic insights into establishing a generally applicable RNA-mutagenesis method.

  10. Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing

    PubMed Central

    Fukuda, Masatora; Umeno, Hiromitsu; Nose, Kanako; Nishitarumizu, Azusa; Noguchi, Ryoma; Nakagawa, Hiroyuki

    2017-01-01

    As an alternative to DNA mutagenesis, RNA mutagenesis can potentially become a powerful gene-regulation method for fundamental research and applied life sciences. Adenosine-to-inosine (A-to-I) RNA editing alters genetic information at the transcript level and is an important biological process that is commonly conserved in metazoans. Therefore, a versatile RNA-mutagenesis method can be achieved by utilising the intracellular RNA-editing mechanism. Here, we report novel guide RNAs capable of inducing A-to-I mutations by guiding the editing enzyme, human adenosine deaminase acting on RNA (ADAR). These guide RNAs successfully introduced A-to-I mutations into the target-site, which was determined by the reprogrammable antisense region. In ADAR2-over expressing cells, site-directed RNA editing could also be performed by simply introducing the guide RNA. Our guide RNA framework provides basic insights into establishing a generally applicable RNA-mutagenesis method. PMID:28148949

  11. Twist and Shout? Developing Sixth-Form Students' Thinking about Historical Interpretation

    ERIC Educational Resources Information Center

    Chapman, Arthur

    2011-01-01

    Understanding historical interpretation involves understanding how historical knowledge is constructed. How do sixth formers model historical epistemology? In this article Arthur Chapman examines a small sample of data relating to sixth form students' ideas about why historians construct differing interpretations of the past. He argues that…

  12. The Diagnostic Accuracy and Construct Validity of the Structured Photographic Expressive Language Test-Preschool: Second Edition

    ERIC Educational Resources Information Center

    Greenslade, Kathryn J.; Plante, Elena; Vance, Rebecca

    2009-01-01

    Purpose: In order to support evidence-based practice, this study served to evaluate the diagnostic accuracy, convergent validity, and divergent validity of the Structured Photographic Expressive Language Test-Preschool: Second Edition (SPELT-P2; J. Dawson, J. A. Eyer, J. Fonkalsrud, 2005) in order to determine whether it can be used as a valid…

  13. Helping Children through Books: A Selected Booklist. Third Revised Edition.

    ERIC Educational Resources Information Center

    Pearl, Patricia

    An update of a bibliotherapy bibliography compiled by the Church and Synagogue Library Association (CSLA) a decade ago, this list includes books intended for children from a preschool to a sixth-grade reading level. Although the first edition included works concerning religion, this edition does not, since those works are already covered in other…

  14. SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM TECHNOLOGY PROFILES: SIXTH EDITION

    EPA Science Inventory

    The Superfund Innovative Technology Evaluation (SITE) Program evaluates new and promising treatment and monitoring and measurement technologies for cleanup of hazardous waste sites. The program was created to encourage the development and routine use of innovative treatment techn...

  15. MOPAC Manual. Sixth Edition. A General Molecular Orbital Package

    DTIC Science & Technology

    1990-11-01

    THERMOCHEMISTRY ...... .. 6-9 6.11 REACTION COORDINATES . . . . . . ........ 6-17 6.12 SPARKLES . . . . . . . ...... . ......... 6-31 6.13 MECHANISM OF THE...the component of spin for every microstate must be the same, except for teaching purposes. Two microstates of different components of spin will have a...zero matrix element connecting them. No warning will be given as this is a reasonable operation in a teaching situation. For example, if all states

  16. Keys to soil taxonomy by soil survey staff (sixth edition)

    SciTech Connect

    1994-12-31

    This publication, Keys to Soil Taxonomy, serves two purposes. It provides the taxonomic keys necessary for the classification of soils according to Soil Taxonomy in a form that can be used easily in the field, and it also acquaints users of Soil Taxonomy with recent changes in the classification system. This volume includes all revisions of the keys that have so far been approved, replacing the original keys in Soil Taxonomy: A Basic System of Soil Classification for Making and Interpreting Soil Surveys (1975), the work on which this abridged version, first published in 1983, is based. This publication incorporates all amendments approved to date and published in National Soil Taxonomy Handbook (NSTH) Issues 1-17.

  17. The College Cost Book, 1985-86. Sixth Edition.

    ERIC Educational Resources Information Center

    College Entrance Examination Board, New York, NY. Coll. Scholarship Service.

    Expenses at 3,500 schools and colleges are identified, and information is presented on student financial aid, estimating financial need, and managing money. College costs are based on the following: tuition and fees, books and supplies, room and board, personal expenses, and transportation. The following financial aid sources are examined: Pell…

  18. Financing Education in a Climate of Change. Sixth Edition.

    ERIC Educational Resources Information Center

    Burrup, Percy E.; Brimley, Vern, Jr.; Garfield, Rulon R.

    As the United States prepares for the 21st century, questions regarding the high cost of education have increased in volume. Many of these questions and issues are addressed in this textbook. The text is intended for a beginning course in school finance, but school administrators, teachers, school board members, legislators, and others interested…

  19. Manual for Librarians in Small Hospitals. Sixth Edition.

    ERIC Educational Resources Information Center

    Graham, Elaine, Ed.; Kesti, Julie, Ed.

    This manual is designed to aid the inexperienced person assigned to a hospital library and given the responsibility of ordering library materials, organizing the collection, borrowing from other libraries, and seeking information. Following a brief introduction, the manual is divided into 10 chapters: (1) Organization and Administration of the…

  20. Human Resources Administration in Education: A Management Approach. Sixth Edition.

    ERIC Educational Resources Information Center

    Rebore, Ronald W.

    This book reflects the changing aspects of school human-resources management. Current concerns include the impact of new laws related to disabilities, civil rights, family and medical leave, and the testing of school bus drivers for alcohol and controlled substances. Also examined are human resources' responsibilities to military reservists and…

  1. Indicators of School Crime and Safety, 2003. Sixth Edition.

    ERIC Educational Resources Information Center

    DeVoe, Jill F.; Peter, Katharin; Kaufman, Phillip; Ruddy, Sally A.; Miller, Amanda K.; Planty, Mike; Snyder, Thomas D.; Rand, Michael R.

    This publication provides the most recent national indicators on school crime and safety. These indicators demonstrate that sizable improvements have occurred in the safety of students: between 1992 and 2001, the violent crime victimization rate at school declined from 48 violent victimizations per 1,000 students in 1992 to 20 such victimizations…

  2. Rock mechanics. Second edition

    SciTech Connect

    Jumikis, A.R.

    1983-01-01

    Rock Mechanics, 2nd Edition deals with rock as an engineering construction material-a material with which, upon which, and within which civil engineers build structures. It thus pertains to hydraulic structures engineering; to highway, railway, canal, foundation, and tunnel engineering; and to all kinds of rock earthworks and to substructures in rock. Major changes in this new edition include: rock classification, rock types and description, rock testing equipment, rock properties, stability effects of discontinuity and gouge, grouting, gunite and shotcrete, and Lugeon's water test. This new edition also covers rock bolting and prestressing, pressure-grouted soil anchors, and rock slope stabilization.

  3. The Sixth "P"--Politics

    ERIC Educational Resources Information Center

    Fink, Dean

    2013-01-01

    Invitational theory presents the concept of invitations as related to five factors: people, places, policies, programs, and processes (Purkey & Schmidt, 1990). In this article, the author proposes the addition of a sixth "P," politics. The assumption is that without addressing the political aspect of schools and school systems,…

  4. The Sixth Great Mass Extinction

    ERIC Educational Resources Information Center

    Wagler, Ron

    2012-01-01

    Five past great mass extinctions have occurred during Earth's history. Humanity is currently in the midst of a sixth, human-induced great mass extinction of plant and animal life (e.g., Alroy 2008; Jackson 2008; Lewis 2006; McDaniel and Borton 2002; Rockstrom et al. 2009; Rohr et al. 2008; Steffen, Crutzen, and McNeill 2007; Thomas et al. 2004;…

  5. Marihuana and Health. Sixth Annual Report to the U.S. Congress from the Secretary of Health, Education, and Welfare, 1976.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD.

    This edition, the sixth in the series of annual reports, is a nontechnical summary updating developments in marihuana research with selected references from the fifth edition. Areas of discussion include: (1) nature and extent of marihuana use in the United States; (2) marihuana use among high school seniors; (3) an overview of use trends; (4)…

  6. The Diagnostic Accuracy and Construct Validity of the Structured Photographic Expressive Language Test—Preschool: Second Edition

    PubMed Central

    Greenslade, Kathryn J.; Plante, Elena; Vance, Rebecca

    2009-01-01

    Purpose In order to support evidence-based practice, this study served to evaluate the diagnostic accuracy, convergent validity, and divergent validity of the Structured Photographic Expressive Language Test—Preschool: Second Edition (SPELT–P2; J. Dawson, J. A. Eyer, J. Fonkalsrud, 2005) in order to determine whether it can be used as a valid measure for identifying language impairment in preschoolers. Method The SPELT–P2 was administered to 54 children with typically developing language and 42 children with specific language impairment. Results A discriminant analysis revealed good sensitivity (90.6%), good specificity (100%), and good positive and negative likelihood ratios, with a standard score cutoff point of 87 used to determine group membership. Analyses of convergent and divergent validity also supported use of the SPELT–P2 for identifying language impairment in preschoolers. Implications The empirical evidence supports use of the SPELT–P2 as a valid measure for correctly identifying the presence or absence of language impairment in 4- and 5-year-old preschool children. PMID:18840676

  7. Construct Validity of the Chinese Version of the Psycho-Educational Profile-3rd Edition (CPEP-3)

    ERIC Educational Resources Information Center

    Shek, Daniel Tan Lei; Yu, Lu

    2014-01-01

    Objective behavioral assessment of autism spectrum disorder (ASD) in early childhood is essential for guiding appropriate treatment and intervention. In contrast to Western societies, validated measures of ASD are very limited in different Chinese contexts. The present study attempted to examine the construct validity of the Chinese version of…

  8. Using Appleworks V1.3 To Construct Spreadsheet Files for the Apple IIe Computer. First Edition.

    ERIC Educational Resources Information Center

    Schlenker, Richard M.; Schlenker, Deborah S.

    This guide was developed as a "how to" training device for constructing spreadsheet files using AppleWorks on the Apple IIe computer with a Duodisk or two disk drives. Step-by-step instructions are provided for program loading, selecting the spreadsheet option, setting column widths, naming columns and fields, justifying labels and…

  9. Sixth International Microgravity Combustion Workshop

    NASA Technical Reports Server (NTRS)

    Sacksteder, Kurt (Compiler)

    2001-01-01

    This conference proceedings document is a compilation of papers presented orally or as poster displays to the Sixth International Microgravity Combustion Workshop held in Cleveland, Ohio on May 22-24, 2001. The purpose of the workshop is to present and exchange research results from theoretical and experimental work in combustion science using the reduced-gravity environment as a research tool. The results are contributed by researchers funded by NASA throughout the United States at universities, industry and government research agencies, and by researchers from international partner countries that are also participating in the microgravity combustion science research discipline. These research results are intended for use by public and private sector organizations for academic purposes, for the development of technologies needed for Human Exploration and Development of Space, and to improve Earth-bound combustion and fire-safety related technologies.

  10. Exploring Quality Assurance in Sixth Form Colleges

    ERIC Educational Resources Information Center

    Stoten, David William

    2012-01-01

    Purpose: This paper aims to focus on the changing nature of quality assurance systems within the sixth form college sector. Design/methodology/approach: Ten sixth form colleges were surveyed across England and staff from varying levels within college hierarchies questioned about how quality assurance systems were implemented. Research involved…

  11. The CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitro.

    PubMed

    Lei, Chao; Li, Shi-Yuan; Liu, Jia-Kun; Zheng, Xuan; Zhao, Guo-Ping; Wang, Jin

    2017-01-23

    As Cpf1 cleaves double-stranded DNA in a staggered way, it can be used in DNA assembly. However, the Cpf1 cleavage was found to be inaccurate, which may cause errors in DNA assembly. Here, the Cpf1 cleavage sites were precisely characterized, where the cleavage site on the target strand was around the 22nd base relative to the protospacer adjacent motif site, but the cleavage on the non-target strand was affected by the spacer length. When the spacer length was 20 nt or longer, Cpf1 mainly cleaved around the 14th and the 18th bases on the non-target strand; otherwise, with a shorter spacer (i.e. 17-19 nt), Cpf1 mainly cleaved after the 14th base, generating 8-nt sticky ends. With this finding, Cpf1 with a 17-nt spacer crRNA were employed for in vitro substitution of the actII-orf4 promoter in the actinorhodin biosynthetic cluster with a constitutively expressing promoter. The engineered cluster yielded more actinorhodin and produced actinorhodin from an earlier phase. Moreover, Taq DNA ligase was further employed to increase both the ligation efficiency and the ligation accuracy of the method. We expect this CCTL (Cpf1-assisted Cutting and Taq DNA ligase-mediated Ligation) method can be widely used in in vitro editing of large DNA constructs.

  12. Understanding Physics, First Edition, Study Guide

    NASA Astrophysics Data System (ADS)

    Cummings, Karen; Laws, Priscilla W.; Redish, Edward F.; Cooney, Patrick J.

    2004-04-01

    Built on the foundations of Halliday, Resnick, and Walker's Fundamentals of Physics Sixth Edition, this text is designed to work with interactive learning strategies that are increasingly being used in physics instruction (for example, microcomputer-based labs, interactive lectures, etc. ). In doing so, it incorporates new approaches based upon Physics Education Research (PER), aligns with courses that use computer-based laboratory tools, and promotes Activity Based Physics in lectures, labs, and recitations.

  13. 22. This is an image from the special edition of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. This is an image from the special edition of the Terre Haute Tribune, Thursday, September 17, 1925. Page size is 14" x 19". This is a reproduction of a pen and ink rendering of the building from the southeast. On microfilm in the Vigo Country Public Library. - John T. Beasley Building, 632 Cherry Street (between Sixth & Seventh Streets), Terre Haute, Vigo County, IN

  14. Effect of Electronic Editing on Error Rate of Newspaper.

    ERIC Educational Resources Information Center

    Randall, Starr D.

    1979-01-01

    A study of a North Carolina newspaper indicates that newspapers using fully integrated electronic editing systems have fewer errors in spelling, punctuation, sentence construction, hyphenation, and typography than newspapers not using electronic editing. (GT)

  15. An investigation of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder construct as a prototype category and the psychometric properties of the diagnostic criteria.

    PubMed

    Hummelen, Benjamin; Wilberg, Theresa; Pedersen, Geir; Karterud, Sigmund

    2006-01-01

    This study investigated several aspects of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder (APD) construct, with emphasis on the psychometric properties of the diagnostic criteria and the prototype nature of the construct. A sample of 1,058 patients from the Norwegian Network of Psychotherapeutic Day Hospitals was examined by means of exploratory factor analysis, correlation, and diagnostic efficiency statistics, chi(2) analysis, and frequency distribution. The results indicated that APD is a 1-dimensional construct with good internal consistency. The criteria had acceptable diagnostic efficiency; criterion 3 performed poorest. Number of APD criteria showed no distinct threshold between No-APD and patients with APD. Sixty-two different combinations of any 4 APD criteria occurred. It can be concluded that the prototype model fitted the data well and that the APD diagnostic criteria perform well in the current classification system. The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition hierarchy of criteria was not supported.

  16. Proceedings of the Sixth General Meeting of the International VLBI Service for Geodesy and Astrometry

    NASA Technical Reports Server (NTRS)

    Behrend, Dirk (Editor); Baver, Karen D. (Editor)

    2010-01-01

    This volume is the proceedings of the sixth General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Hobart, Tasmania, Australia, February 7-13, 2010. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2010. The keynote of the sixth GM was the new perspectives of the next generation VLBI system under the theme "VLBI2010: From Vision to Reality". The goal of the meeting was to provide an interesting and informative program for a wide cross-section of IVS members, including station operators, program managers, and analysts. This volume contains 88 papers. All papers were edited by the editors for usage of the English language, form, and minor content-related issues.

  17. A Study on Sixth Grade Students' Misconceptions and Errors in Spatial Measurement: Length, Area, and Volume

    ERIC Educational Resources Information Center

    Tan Sisman, Gulcin; Aksu, Meral

    2016-01-01

    The purpose of the present study was to portray students' misconceptions and errors while solving conceptually and procedurally oriented tasks involving length, area, and volume measurement. The data were collected from 445 sixth grade students attending public primary schools in Ankara, Türkiye via a test composed of 16 constructed-response…

  18. A Comparison of Reliabilities of Graphic and Semantic Differential Factors among Sixth Grade Pupils.

    ERIC Educational Resources Information Center

    Pierson, Ellery M.

    It was wished to determine the relative reliabilities of graphic and semantic differential factors to evaluate applicability of two rival models to the measurement of pupil attitudes. Data was collected from a sample of sixth grade pupils on both abstract graphic and typical semantic differential scales. Reliability estimates were constructed from…

  19. Servant Leadership in English Sixth Form Colleges: What Do Teachers Tell Us?

    ERIC Educational Resources Information Center

    Stoten, David William

    2013-01-01

    Purpose: The purpose of this paper is to investigate whether servant leadership can be applied to college management. The research methodology involved questionnaire and co-constructed discussion eliciting the views of teachers on how they interpret leadership in a sixth form college. Three other models of leadership were discussed along with…

  20. Doing Science Their Way: An Ethnographic Study of Sixth Grade Girls' Engagement with School Science

    ERIC Educational Resources Information Center

    Giuriceo, Carol M.

    2011-01-01

    This study focuses on the experiences and perspectives of sixth grade girls in a moderately-sized East Coast city as they construct meaning through active engagement in a science classroom and analyzes the ways in which girls change roles and incorporate social interaction during science activities to create their own unique engagement in science.…

  1. Latin Vibes Curriculum: Sixth and Seventh Grades.

    ERIC Educational Resources Information Center

    Lederer, Debra; And Others

    A sixth- and seventh-grade program "Latin Vibes," developed in response to a rising demand within the community for more student understanding of the evolution of the English language, is outlined. The courses for each grade chronicle the influences of Latin and the romance languages on the development of English over the centuries. The program…

  2. Sixth Grade: Fall and Winter Curriculum Guide.

    ERIC Educational Resources Information Center

    Jacobs, Joel Robert, Ed.

    Activity plans for sixth grade outdoor education experiences comprise the bulk of this curriculum guide. Many of the outlines have been developed through practical application and experimentation by staff members of the Outdoor and Environmental Education Center (OEEC) of the Harrisburg, Pennsylvania, City Schools. Activities and studies for the…

  3. Sixth Grade Readover: A Recipe for Success.

    ERIC Educational Resources Information Center

    Krapp, JoAnn Vergona

    1995-01-01

    Discusses the planning and implementation of a sixth-grade sleepover in a school library to celebrate National Library Week and to provide literature enrichment. Topics include student selection criteria; preparation; schedule and sample of activities; commentary and evaluation of event. Sidebars offer information on items to bring for overnight…

  4. Health, United States, 1981. [Sixth Annual Report].

    ERIC Educational Resources Information Center

    National Center for Health Services Research (DHHS/PHS), Hyattsville, MD.

    This document provides the sixth annual report on the health status of the citizens of the United States. Submitted by the Secretary of Health and Human Services to the President and Congress in compliance with Section 308 of the Public Health Services Act, the report presents statistics concerning recent trends in the health care sector along…

  5. 75 FR 23823 - Sixth Northwest Electric Power and Conservation Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... POWER AND CONSERVATION PLANNING COUNCIL Sixth Northwest Electric Power and Conservation Plan AGENCY: Pacific Northwest Electric Power and Conservation Planning Council (Northwest Power and Conservation Council; the Council). ACTION: Notice of adoption of the Sixth Northwest Electric Power and...

  6. Sixth Grade Students Who Use Alcohol

    PubMed Central

    Pasch, Keryn E.; Perry, Cheryl L.; Stigler, Melissa H.; Komro, Kelli A.

    2008-01-01

    Young adolescent alcohol users drink at higher rates than their peers throughout adolescence and appear to be less amenable to intervention. This study compares those who reported alcohol use in the past year to those who reported no use in a multiethnic, urban sample of sixth graders in 61 schools in Chicago in 2002 (N = 4,150). Demographic, behavioral, intrapersonal, and socioenvironmental factors were identified based on behavioral theories and potential mediators of the Project Northland Chicago intervention. Single and multiple regression models were created for users and nonusers to determine associations between these factors and alcohol use behavior and intentions. The multiple regression models explained 35% and 56% of the variance in alcohol use behavior and intentions between students for nonusers and users, respectively. Results suggest that primary prevention programs for alcohol use should occur prior to sixth grade, particularly for the substantial group at high risk for early use. PMID:18303109

  7. Sixth underground coal-conversion symposium

    SciTech Connect

    Not Available

    1980-01-01

    The sixth annual underground coal conversion symposium was held at Shangri-la near Afton, Oklahoma, July 13 to 17, 1980. Sessions were developed to: Doe Field Programs, Major Industry Activity, Mathematical Modeling, Laboratory Studies, Environmental Studies, Economics, Instruments and Controls, and General Topics. Fifty-two papers from the proceedings have been entered individually into EDB and ERA. Thirteen papers had been entered previously from other sources. (LTN)

  8. [Genome editing of industrial microorganism].

    PubMed

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  9. Physics, Laboratory Manual-Student Version , 6th Edition

    NASA Astrophysics Data System (ADS)

    Cutnell, John D.; Johnson, Kenneth W.

    2004-01-01

    This Sixth Edition helps readers understand the interrelationships among basic physics concepts and how they fit together to describe our physical world. Throughout the book, the authors emphasize the relevance of physics to our everyday lives. Real-world physics applications, including many biomedical applications, show how physics principles come into play over and over again in our lives. Problem Solving Insights explain each calculation in detail, guiding readers through the quantitative process Includes a CD containing physics simulations

  10. Physics, AP Student Study Guide, 6th Edition

    NASA Astrophysics Data System (ADS)

    Cutnell, John D.; Johnson, Kenneth W.

    2003-11-01

    This Sixth Edition helps readers understand the interrelationships among basic physics concepts and how they fit together to describe our physical world. Throughout the book, the authors emphasize the relevance of physics to our everyday lives. Real-world physics applications, including many biomedical applications, show how physics principles come into play over and over again in our lives. Problem Solving Insights explain each calculation in detail, guiding readers through the quantitative process Includes a CD containing physics simulations

  11. A systematic study of genetic algorithms with genotype editing

    SciTech Connect

    Huang, C. F.; Rocha, L. M.

    2004-01-01

    This paper presents our systematic study on an RNA-editing computational model of Genetic Algorithms (GA). This model is constructed based on several genetic editing characteristics that are gleaned from the RNA editing system as observed in several organisms. We have expanded the traditional Genetic Algorithm with artificial editing mechanisms as proposed by [15]. The incorporation of editing mechanisms provides a means for artificial agents with genetic descriptions to gain greater phenotypic plasticity, which may be environmentally regulated. The systematic study of this RNA-editing model has shed some light into the evolutionary implications of RNA editing and how to select proper RNA editors for design of more robust GAS. The results will also show promising applications to complex real-world problems. We expect that the framework proposed will both facilitate determining the evolutionary role of RNA editing in biology, and advance the current state of research in Evolutionary Computation.

  12. Fundamentals of Physics, Extended 7th Edition

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl

    2004-05-01

    No other book on the market today can match the 30-year success of Halliday, Resnick and Walker's Fundamentals of Physics! Fundamentals of Physics, 7th Edition and the Extended Version, 7th Edition offer a solid understanding of fundamental physics concepts, helping readers apply this conceptual understanding to quantitative problem solving, in a breezy, easy-to-understand style. A unique combination of authoritative content and stimulating applications. * Numerous improvements in the text, based on feedback from the many users of the sixth edition (both instructors and students) * Several thousand end-of-chapter problems have been rewritten to streamline both the presentations and answers * 'Chapter Puzzlers' open each chapter with an intriguing application or question that is explained or answered in the chapter * Problem-solving tactics are provided to help beginning Physics students solve problems and avoid common error * The first section in every chapter introduces the subject of the chapter by asking and answering, "What is Physics?" as the question pertains to the chapter * Numerous supplements available to aid teachers and students The extended edition provides coverage of developments in Physics in the last 100 years, including: Einstein and Relativity, Bohr and others and Quantum Theory, and the more recent theoretical developments like String Theory.

  13. Construction

    DTIC Science & Technology

    2002-01-01

    Harbor Deepening Project, Jacksonville, FL Palm Valley Bridge Project, Jacksonville, FL Rotary Club of San Juan, San Juan, PR Tren Urbano Subway...David. What is nanotechnology? What are its implications for construction?, Foresight/CRISP Workshop on Nanotechnology, Royal Society of Arts

  14. Construction

    DTIC Science & Technology

    2002-01-01

    San Juan, PR Tren Urbano Subway Project, San Juan, PR U.S. Army South, San Juan, PR U.S. Coast Guard Housing Project, San Juan, PR U.S. Coast Guard...construction?, Foresight/CRISP Workshop on Nanotechnology, Royal Society of Arts . Cheltenham, England: 2001, p.5. 56 Concrete Proposals, Economist, July 24

  15. Basic Wiring. Third Edition. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Kaltwasser, Stan; Flowers, Gary; Blasingame, Don; Batson, Larry; Ipock, Dan; Carroll, Charles; Friesen, Wade; Fleming, Glenn

    This publication contains both a teacher edition and a student edition of materials for a foundation course in an electrical wiring program. The course introduces basic concepts and skills that are prerequisites to residential wiring and commercial and industrial wiring courses. The contents of the materials are tied to measurable and observable…

  16. Major Appliance Repair. Teacher Edition and Student Edition. Second Edition.

    ERIC Educational Resources Information Center

    Smreker, Gene; Calvert, King

    This second edition contains teacher and student guides for 14 units of instruction in major appliance repair. Each unit in the teacher edition includes some or all of the following basic components: objective sheet, suggested activities, answers to assignment sheets, answers to the written test, written test, a unit evaluation form, teacher…

  17. Diesel Technology: Introduction. Teacher Edition [and] Student Edition. Second Edition.

    ERIC Educational Resources Information Center

    Joerschke, John D.; Eichhorn, Lane

    This complete teacher edition of a diesel technology course consists of introductory pages, teacher pages, and the student edition. The introductory pages provide these tools: training and competency profile; National Automotive Technicians Education Foundation Crosswalk; instructional/task analysis; basic skills icons and classifications; basic…

  18. The levels of edit, second edition

    NASA Technical Reports Server (NTRS)

    Vanburen, R.; Buehler, M. F.

    1980-01-01

    The editorial process is analyzed, and five levels of edit are identified. These levels represent cumulative combinations of nine types of edit: Coordination, Policy, Integrity, Screening, Copy Clarification, Format, Mechanical Style, Language, and Substantive. The levels and types of edit, although developed for specific use with external reports at the Jet Propulsion Laboratory, cover the general range of technical editing, especially as it applies to an in-house technical publications organization. Each type of edit is set forth in terms of groups of actions to be performed by editor. The edit-level concept has enhanced understanding and communication among editors, authors, and publications managers concerning the specific editorial work to be done on each manuscript. It has also proved useful as a management tool for estimating and monitoring cost.

  19. The role of RNA editing in dynamic environments

    SciTech Connect

    Rocha, L. M.; Huang, C. F.

    2004-01-01

    This paper presents a computational methodology based on Genetic Algorithms with Genotype Editing (GAE) for investigating the role of RNA editing in dynamic environments. This model is constructed based on several genetic editing characteristics that are gleaned from the RNA editing system as observed in several organisms. We have previously expanded the traditional Genetic Algorithm (GA) with artificial editing mechanisms (Rocha, 1995, 1997), and studied the benefits of including straightforward Genotype Editing in GA for several machine learning problems (Huang and Rocha, 2003, 2004). We show that the incorporation of genotype editing provides a means for artificial agents with genetic descriptions to gain greater phenotypic plasticity. Artificial agents use genotype edition to their advantage by linking it to environmental context. The ability to link changes in the environment with editing parameters gives organisms an adaptive advantage as genotype expression can become contextually regulated. The study of this RNA editing model in changing environments has shed some light into the evolutionary implications of RNA editing. We expect that our methodology will both facilitate determining the evolutionary role of RNA editing in biology, and advance the current state of research in Evolutionary Computation and Artificial Life.

  20. Book Review: Astronomy: A Self-Teaching Guide, 6th Edition

    NASA Astrophysics Data System (ADS)

    Marigza, R. N., Jr.

    2009-03-01

    The sixth edition of Moche's book is up-to-date with the latest in astronomy. It contains accurate astronomical data on stars and constellations. The topics are incorporated with web site addresses for the reader to expand his/her knowledge and see high-resolution images of the celestial targets. This edition incorporates new discoveries and suggestions made prior to the first editions. Among the new developments is the twenty-first-century research into black holes, active galaxies and quasars, searches for life in space, origin and structure of our universe, and the latest in ground and space telescopes.

  1. Life experience of sixth-grade students in analog domains of sixth-grade science textbooks

    NASA Astrophysics Data System (ADS)

    Wagamon, Barbara J.

    This study was conducted to determine if analog domains in sixth grade science textbooks were common to the life experience of sixth grade students and if experience differed according to moderating variables. The researcher reviewed three sixth grade general science textbooks and selected analogies that were unsupported by extended text, photos, or diagrams. Analogies were limited to ones which were unsupported because the intent was to identify students who were ready by virtue of life experience to confront analogies unaided by contextual clues. The researcher designed the Life Experiences in Analog Domains (LEAD) Questionnaire to survey students in 50 analog domains. Subjects of the study were 331 sixth grade students from an urban school district. Thirty were tested with the instrument one year later. Data on age, gender, ethnicity and income were analyzed for variance. Standardized achievement test scores were correlated to the LEAD Questionnaire. Results revealed sharp contrasts of experience by analog domain. Experience in analog domains was indicated 52% of the time overall. There were significant differences in the experience of students grouped by moderating variables. Younger students reported more experience than older students. The higher income group reported more experience than the lower income group. Caucasian students reported more experience overall than African American students. Chi-square tests revealed that differences in scores by ethnicity were not controlled by income. of three skills, reading comprehension, mathematics, and science, reading comprehension was most closely correlated to questionnaire score. Results suggest that many of the sixth grade students in the study may be without experience in analog domains when they encounter analogies in a textbook. Assuming subsequent implementations of the Questionnaire confirm these results, teachers should survey life experience of students and help them develop experiences that complement

  2. Fundamentals of Physics, 6th Edition Enhanced Problems Version

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl

    2002-04-01

    No other text on the market today can match the success of Halliday, Resnick and Walker's Fundamentals of Physics. This text continues to outperform the competition year after year, and the new edition will be no exception. Intended for Calculus-based Physics courses, the 6th edition of this extraordinary text is a major redesign of the best-selling 5th edition, which still maintains many of the elements that led to its enormous success. Jearl Walker adds his unique style to this edition with the addition of new problems designed to capture, and keep, students' attention. Nearly all changes are based on suggestions from instructors and students using the 5th edition, from reviewer comments, and from research done on the process of learning. The primary goal of this text is to provide students with a solid understanding of fundamental physics concepts, and to help them apply this conceptual understanding to quantitative problem solving. The principal goal of Halliday-Resnick-Walker is to provide instructors with a tool by which they can teach students how to effectively read scientific material and successfully reason through scientific questions. To sharpen this tool, the Enhanced Problems Version of the sixth edition of Fundamentals of Physics contains over 1000 new, high-quality problems that require thought and reasoning rather than simplistic plugging of data into formulas.

  3. Relativistic effects on sixth group hydrides

    NASA Astrophysics Data System (ADS)

    Pisani, L.; Clementi, E.

    1994-08-01

    Dirac-Fock (DF) and Hartree-Fock (HF) calculations have been performed for the ground state configuration of the H2O, H2S, H2Se, H2Te, and H2Po molecules. Equilibrium geometries, atomization energies, and molecular orbitals energies are evaluated with both methods, compared and discussed with the help of population analysis and atomic orbital energies. Particular attention has been given to a qualitative understanding of the relativistic effects. Molecular spin-orbits corrections appear to be essential to a description of some in the sixth group hydrides set. A description of the relativistic computer program is presented elsewhere [L. Pisani and E. Clementi, J. Comput. Chem. (in press)].

  4. Minutes of the Sixth CEOS Plenary Meeting

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Committee on Earth Observations Satellites (CEOS) minutes for the sixth plenary meeting held in London, December 9-11, 1992 are presented. Attending as prospective members were the Russian Space Agency (RSA), the Committee for Hydrometeorology and Environmental Monitoring of the Ministry for Ecology and Natural resources of the Russian Federation (ROSCOMGIDROMET), the Chinese Academy of Space Technology (CAST) and the National Remote Sensing Center of China (NRSCC). Actions taken at the meeting included membership issues, CEOS proposals, data policy, and working group reports. Data requirements of CEOS affiliates were also reported on. Additional summations and statements as well as lists of participants and future meetings are included. In general, topics covered related to remote sensing and global change.

  5. The sixth generation robot in space

    NASA Technical Reports Server (NTRS)

    Butcher, A.; Das, A.; Reddy, Y. V.; Singh, H.

    1990-01-01

    The knowledge based simulator developed in the artificial intelligence laboratory has become a working test bed for experimenting with intelligent reasoning architectures. With this simulator, recently, small experiments have been done with an aim to simulate robot behavior to avoid colliding paths. An automatic extension of such experiments to intelligently planning robots in space demands advanced reasoning architectures. One such architecture for general purpose problem solving is explored. The robot, seen as a knowledge base machine, goes via predesigned abstraction mechanism for problem understanding and response generation. The three phases in one such abstraction scheme are: abstraction for representation, abstraction for evaluation, and abstraction for resolution. Such abstractions require multimodality. This multimodality requires the use of intensional variables to deal with beliefs in the system. Abstraction mechanisms help in synthesizing possible propagating lattices for such beliefs. The machine controller enters into a sixth generation paradigm.

  6. 9. SANDSORTING BUILDING, SIXTH (TOP) FLOOR, VIEW OF ELECTRIC MOTOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. SAND-SORTING BUILDING, SIXTH (TOP) FLOOR, VIEW OF ELECTRIC MOTOR THAT POWERS ELEVATOR No. (ELEVATOR No. 2 EXTENDS FROM THE THIRD TO THE SIXTH FLOOR) AND WOODEN CHUTE, LOOKING NORTHWEST - Mill "C" Complex, Sand-Sorting Building, South of Dee Bennet Road, near Illinois River, Ottawa, La Salle County, IL

  7. Newspapers in Science Education: A Study Involving Sixth Grade Students

    ERIC Educational Resources Information Center

    Lai, Ching-San; Wang, Yun-Fei

    2016-01-01

    The purpose of this study was to explore the learning performance of sixth grade elementary school students using newspapers in science teaching. A quasi-experimental design with a single group was used in this study. Thirty-three sixth grade elementary school students participated in this study. The research instruments consisted of three…

  8. REORGANIZED SCIENCE CURRICULUM, 6A, SIXTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE NINTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SIXTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THE SIXTH GRADE SUPPLEMENT IS IN THREE VOLUMES. VOLUME 6A HAS A DETAILED OUTLINE OF THE SUBJECT MATTER FOR…

  9. The Interdependence of Sixth Graders' School Attitudes and Academic Performance.

    ERIC Educational Resources Information Center

    Glick, Oren

    In this study, data were obtained from sixth grade students on attitudes toward each of four aspects of the school experience and on academic achievement. Data were available from 159 males and 199 females from 17 sixth grade classrooms in 17 schools within the Kansas City school district. Attitudes toward school were measured with the Pupil…

  10. Teaching Literacy in Sixth Grade. Tools for Teaching Literacy Series

    ERIC Educational Resources Information Center

    Wood, Karen; Mraz, Maryann

    2005-01-01

    Sixth grade marks the transition to middle school and, for many students, the transition to early adolescence. The sixth-grade classroom is a place where problem-solving and abstract thinking skills can flourish as teachers devise creative ways to integrate language arts with effective content-area instruction. This book walks the reader through…

  11. Green Power Marketing in the United States: A Status Report, Sixth Edition

    SciTech Connect

    Bird, L.; Swezey, B.

    2003-10-01

    Voluntary consumer decisions to purchase electricity supplied from renewable energy sources represent a powerful market support mechanism for renewable energy development. Beginning in the early 1990s, a small number of U.S. utilities began offering''green power'' options to their customers. Since then, these products have become more prevalent both from utilities and in states that have introduced competition into their retail electricity markets. Today, nearly 50% of all U.S. consumers have an option to purchase some type of green power product from a retail electricity provider. Currently, more than 350 investor-owned utilities, rural electric cooperatives, and other publicly owned utilities in 33 states offer green power programs. This report provides an overview of green power marketing activity in the United States. It describes green power product offerings, consumer response, and recent industry trends. The three distinct markets for green power are discussed in turn.

  12. United States Air Force Statistical Digest, Fiscal Year 1951. Sixth Edition

    DTIC Science & Technology

    1952-11-18

    Capacit1’ No"""- Occupied Dot in Norma ’- Occupied lormaJ. Ocoupbd No"""- Oooupied lormaJ. OCcupied 10"""- Oocupl.d Capll.cltT or Uss tor Cllp801tJ’ or...e. 13 8,853 - 13 8,853 - - - Panoramic Adaptor, APA -41 •• "•••••• " ••• •• 6 17,456 - 6 17,456 . - - Radio Ccapasll, AN/crP.P-7...191 4,735,995 - 191 4,735,995 - - - A1rbOl’Dll DF :Ju1pmtent, AN/ APA -24 •••••••• •• 6 75,848 - 6 75,846 - - - Radar Set, All APQ-43 and

  13. Who's Involved with Hunger: An Organization Guide for Education and Advocacy. Sixth Edition.

    ERIC Educational Resources Information Center

    Kutzner, Patricia L.; And Others

    This directory provides key information on agencies and organizations instrumental in the fight against hunger. The guide is divided into three parts. Part 1, "Governmental Organizations and Agencies," lists: (1) "U.S. Congress"; (2) "U.S. Federal Government Agencies"; and (3) "United Nations Intergovernmental Organizations." Part 2, "World…

  14. Characteristics of Emotional and Behavioral Disorders of Children and Youth. Sixth Edition.

    ERIC Educational Resources Information Center

    Kauffman, James M.

    This book is designed as an introductory text on special education for children and youth with emotional and behavioral disorders. Part 1 addresses the problems in the definition of emotional and behavioral disorders, the prevalence of the disorders, the growth of the field of emotional and behavior disorders, and major current trends. Part 2…

  15. A Network of Knowledge: Directory of Criminal Justice Information Sources. Sixth Edition.

    ERIC Educational Resources Information Center

    Goldberg, Paula R., Comp.

    This directory of over 170 criminal justice information sources is based on a 1986 survey of more than 400 criminal justice agencies. The following guidelines were used to select organizations/information resources: (1) the organization's service area is national or regional in scope; (2) the provision of criminal justice-related information is a…

  16. Lifelong Learning Trends: A Profile of Continuing Higher Education. Sixth Edition.

    ERIC Educational Resources Information Center

    Gwynn, Peter, Ed.

    This publication presents national data on trends and participation in continuing higher education. Section 1, "An Expanding Demand for Lifelong Learning," discusses how the supply of new entrants will be insufficient for future labor needs; more women are participating in the workforce; and more high school graduates plan to enroll in…

  17. Sixth national stakeholder workshop summary report

    SciTech Connect

    1999-03-01

    On June 17--18, 1998, the Department of Energy`s (DOE) Office of Worker and Community Transition convened its sixth National Stakeholder Workshop at the Ramada Plaza Hotel Old Town in Alexandria, Virginia. Approximately 325 stakeholders attended representing DOE headquarters and field offices, contractors, labor organizations, state and local government, education and community interest groups. The meeting addressed the progress made on the issues and challenges identified at the last stakeholder`s meeting in Oakland, California on April 9--11, 1997. Also discussed were the full range of the Department`s work force issues and creative solutions to the inherent challenges of simultaneously implementing the Department`s post Cold-War mission, work force restructuring guidance, contract reform objectives, asset disposition, performance-based management requirements, and business process improvement policies. The format of the Workshop included several plenary sessions and a number of small group discussion sessions. The small group sessions focused on topics related to labor issues, work force restructuring, work force planning, community transition, and employee concerns. The sessions provided a wide range of views on worker and community transition issues. The plenary sessions of the Workshop included presentations on the following topics: welcome and introductions; opening remarks; building a better labor-management relationship; keynote speech from Secretary of Energy Federico Pena; meeting tomorrow`s challenges (early site closures); harnessing the contracting process to encourage local growth; and, the British experience in economic conversion.

  18. Taste of Fat: A Sixth Taste Modality?

    PubMed

    Besnard, Philippe; Passilly-Degrace, Patricia; Khan, Naim A

    2016-01-01

    An attraction for palatable foods rich in lipids is shared by rodents and humans. Over the last decade, the mechanisms responsible for this specific eating behavior have been actively studied, and compelling evidence implicates a taste component in the orosensory detection of dietary lipids [i.e., long-chain fatty acids (LCFA)], in addition to textural, olfactory, and postingestive cues. The interactions between LCFA and specific receptors in taste bud cells (TBC) elicit physiological changes that affect both food intake and digestive functions. After a short overview of the gustatory pathway, this review brings together the key findings consistent with the existence of a sixth taste modality devoted to the perception of lipids. The main steps leading to this new paradigm (i.e., chemoreception of LCFA in TBC, cell signaling cascade, transfer of lipid signals throughout the gustatory nervous pathway, and their physiological consequences) will be critically analyzed. The limitations to this concept will also be discussed in the light of our current knowledge of the sense of taste. Finally, we will analyze the recent literature on obesity-related dysfunctions in the orosensory detection of lipids ("fatty" taste?), in relation to the overconsumption of fat-rich foods and the associated health risks.

  19. Sixth workshop on geothermal reservoir engineering: Proceedings

    SciTech Connect

    Ramey, H.J. Jr.; Kruger, P.

    1980-12-18

    INTRODUCTION TO THE PROCEEDINGS OF THE SIXTH GEOTHERMAL RESERVOIR ENGINEERING WORKSHOP, STANFORD GEOTHERMAL PROGRAM Henry J. Ramey, Jr., and Paul Kruger Co-Principal Investigators Ian G. Donaldson Program Manager Stanford Geothermal Program The Sixth Workshop on Geothermal Reservoir Engineering convened at Stanford University on December 16, 1980. As with previous Workshops the attendance was around 100 with a significant participation from countries other than the United States (18 attendees from 6 countries). In addition, there were a number of papers from foreign contributors not able to attend. Because of the success of all the earlier workshops there was only one format change, a new scheduling of Tuesday to Thursday rather than the earlier Wednesday through Friday. This change was in general considered for the better and will be retained for the Seventh Workshop. Papers were presented on two and a half of the three days, the panel session, this year on the numerical modeling intercomparison study sponsored by the Department of Energy, being held on the second afternoon. This panel discussion is described in a separate Stanford Geothermal Program Report (SGP-TR42). This year there was a shift in subject of the papers. There was a reduction in the number of papers offered on pressure transients and well testing and an introduction of several new subjects. After overviews by Bob Gray of the Department of Energy and Jack Howard of Lawrence Berkeley Laboratory, we had papers on field development, geopressured systems, production engineering, well testing, modeling, reservoir physics, reservoir chemistry, and risk analysis. A total of 51 papers were contributed and are printed in these Proceedings. It was, however, necessary to restrict the presentations and not all papers printed were presented. Although the content of the Workshop has changed over the years, the format to date has proved to be satisfactory. The objectives of the Workshop, the bringing together of

  20. Sixth Nerve Palsy from Cholesterol Granuloma of the Petrous Apex

    PubMed Central

    Roemer, Ségolène; Maeder, Philippe; Daniel, Roy Thomas; Kawasaki, Aki

    2017-01-01

    Herein, we report a patient who had an isolated sixth nerve palsy due to a petrous apex cholesterol granuloma. The sixth nerve palsy appeared acutely and then spontaneously resolved over several months, initially suggesting a microvascular origin of the palsy. Subsequent recurrences of the palsy indicated a different pathophysiologic etiology and MRI revealed the lesion at the petrous apex. Surgical resection improved the compressive effect of the lesion at Dorello’s canal and clinical improvement was observed. A relapsing–remitting sixth nerve palsy is an unusual presentation of this rare lesion. PMID:28261154

  1. Developing new levels of edit

    SciTech Connect

    Prono, J.; DeLanoy, M.; Deupree, R.; Skiby, J.; Thompson, B.

    1998-07-01

    In 1985, the writing and editing group at Los Alamos National Laboratory established four levels of edit for technical reports. When a survey in 1994 showed that both authors and editors felt the levels were not meeting author needs, the authors set about revising them. Their goals were to simplify the editing process, focus editing on improving technical clarity, and ensure that value was added in editing. This paper describes the revision process and product -- three author-based levels of edit.

  2. Classroom Applications of Educational Measurement. Third Edition.

    ERIC Educational Resources Information Center

    Oosterhof, Albert

    This book, designed as an introductory text in educational measurement, presents comprehensive and balanced coverage of all aspects of assessment relevant to classroom teachers, including construction and use of paper-and-pencil and alternative assessments. This edition expands the coverage of alternative assessments and includes a chapter on the…

  3. Digital Video Editing

    ERIC Educational Resources Information Center

    McConnell, Terry

    2004-01-01

    Monica Adams, head librarian at Robinson Secondary in Fairfax country, Virginia, states that librarians should have the technical knowledge to support projects related to digital video editing. The process of digital video editing and the cables, storage issues and the computer system with software is described.

  4. Transcultural Counseling. Second edition.

    ERIC Educational Resources Information Center

    McFadden, John, Ed.

    New trends in transcultural theory, expanded cultural paradigms, innovative counseling techniques for working with diverse ethnic groups, and a comprehensive discussion of professional issues are presented in this second edition of a popular text. This edition is designed to support curriculum changes in counselor education programs to maximize…

  5. Sixth Nerve Palsy in Paediatric Intracranial Hypertension

    PubMed Central

    Reid, Julia E.; Reem, Rachel E.; Aylward, Shawn C.; Rogers, David L.

    2016-01-01

    ABSTRACT The purpose of this study was to report the incidence and describe the characteristics of sixth cranial nerve (CN VI) palsy in paediatric patients with intracranial hypertension (IH). A retrospective chart review of central Ohio children diagnosed with IH over the 3-year period from 2010 to 2013 was conducted. IH without identifiable cause was defined as idiopathic intracranial hypertension (IIH), whereas IH with identifiable pathologic aetiology was deemed secondary intracranial hypertension (SIH). A subset of patients with CN VI palsy was identified. Data collected included patient age, gender, past medical history, aetiology of SIH, ophthalmic examination, lumbar puncture results, neuroimaging results, and response to treatment. Seventy-eight children with intracranial hypertension were included in the study. Nine (11.5%) children (four males, five females; median age 14, range: 3–18) were found to have a unilateral (n = 2) or bilateral (n = 7) CN VI palsy. Five children had IIH; the remaining four had SIH from cerebral venous sinus thrombosis (n = 2) and infection (n = 2). The mean lumbar puncture opening pressure for the nine patients with CN VI palsy was 40 cm H2O (range: 21–65 cm H2O). Papilloedema was present in 8/9 (89%) patients. One patient required a lumboperitoneal shunt, and two others required optic nerve sheath fenestrations in addition to medical management. All cases of CN VI palsy resolved with treatment. In our primary service area, the incidence of CN VI palsy is approximately 12% among paediatric IH patients. The majority of cases with CN VI palsy presented with papilloedema and all cases resolved with treatment of intracranial hypertension. PMID:27928378

  6. 130. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, ROOM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    130. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, ROOM 6156, OFFICE OF THE SECRETARY OF THE INTERIOR, BRONZE WALL CLOCK - U.S. Department of the Interior, Eighteenth & C Streets Northwest, Washington, District of Columbia, DC

  7. 124. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, ROOM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    124. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, ROOM 6154, SUPPORT STAFF ROOM (FORMERLY STUDY) (4' x 5' negative; 8' x 10' print) - U.S. Department of the Interior, Eighteenth & C Streets Northwest, Washington, District of Columbia, DC

  8. 117. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, RECEPTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    117. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, RECEPTION AREA, DETAIL OF BUFFALO DOORKNOB (FRONTAL VIEW) - U.S. Department of the Interior, Eighteenth & C Streets Northwest, Washington, District of Columbia, DC

  9. 115. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, RECEPTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    115. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, RECEPTION AREA, DETAIL OF GRAINED RADIATOR CABINET - U.S. Department of the Interior, Eighteenth & C Streets Northwest, Washington, District of Columbia, DC

  10. 5. DETAIL OF WINDOWS AND CORBELING ON SIXTH FLOOR AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. DETAIL OF WINDOWS AND CORBELING ON SIXTH FLOOR AND CUPOLA OF SOUTH FRONT ELEVATION, LOOKING NORTH - Lembeck & Betz Eagle Brewery, Lager Brew House, 164-170 Ninth Street, Jersey City, Hudson County, NJ

  11. 4. DETAIL OF WINDOWS AND CORBELING ON FIFTH AND SIXTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. DETAIL OF WINDOWS AND CORBELING ON FIFTH AND SIXTH FLOORS OF SOUTH FRONT AND EAST ELEVATIONS, LOOKING NORTHWEST - Lembeck & Betz Eagle Brewery, Lager Brew House, 164-170 Ninth Street, Jersey City, Hudson County, NJ

  12. 3. SIXTH FLOOR VIEW TO WEST, WITH FACE POWDER MAKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SIXTH FLOOR VIEW TO WEST, WITH FACE POWDER MAKING UNIT: CHARGE HOPPER (CENTER FOREGROUND), PERFUME MIXER (LEFT), AND DUST COLLECTOR (REAR CENTER) - Colgate & Company Jersey City Plant, G Block, 81-95 Greene Street, Jersey City, Hudson County, NJ

  13. Implicit learning of fifth- and sixth-order sequential probabilities.

    PubMed

    Remillard, Gilbert

    2010-10-01

    Serial reaction time (SRT) task studies have established that people can implicitly learn sequential contingencies as complex as fourth-order probabilities. The present study examined people's ability to learn fifth-order (Experiment 1) and sixth-order (Experiment 2) probabilities. Remarkably, people learned fifth- and sixth-order probabilities. This suggests that the implicit sequence learning mechanism can operate over a range of at least seven sequence elements.

  14. Anthropology. Teacher Edition. Revised [and] Student Edition.

    ERIC Educational Resources Information Center

    Stark, Rebecca

    The teacher and student editions of this book introduce students to the subject of anthropology and the subfields into which it is divided. Students learn about the beginnings of anthropology as an outgrowth of the curiosity stimulated by the Age of Exploration and how it grew into the basic field it is today. Students examine the origins and…

  15. Construction measurements

    SciTech Connect

    Barry, B.A.

    1988-01-01

    This text/reference on construction measurements contains material concerning electronic surveying and remote sensing. New to this edition is coverage of the GPS satellite positioning system, electronic distance measurement (EDM), laser sweep, calculator techniques, radial surveying and tracking, Loran-C, inertial navigation surveying, 3-point resection, computer software, and electronic fieldbooks. It covers the difference of elevation, angle measurements and directions, coordinate surveying and layout, offshore measurements, and random field and office techniques.

  16. Literacy: Helping Children Construct Meaning. Fourth Edition.

    ERIC Educational Resources Information Center

    Cooper, J. David

    Written to help all teachers provide balanced literacy instruction for all students, this book provides strategies and sample lessons for both direct and indirect literacy instruction. Four complete pieces of literature are provided with updated sample lessons: "Jamaica Tag-Along"; "Mummies, Tombs, and Treasure"; "My Brown…

  17. CRISPR Genome Editing

    Cancer.gov

    A research article about a technique for gene editing known as CRISPR-Cas9. The technique has made it much easier and faster for cancer researchers to study mutations and test new therapeutic targets.

  18. Developing new levels of edit

    SciTech Connect

    Prono, J.K.

    1997-06-01

    Since 1985, Los Alamos National Laboratory (LANL) staff have had four levels of edit to choose from for technical reports. When a CQI survey showed that both authors and editors felt the levels were not meeting author needs, LANL set about revising them. The goals were to simplify the editing process, focus editing on improving technical clarity, and ensure value added in editing. This paper describes the revision process and product--three author-based levels of edit.

  19. Fundamentals of Physics, Student Study Guide, Extended 7th Edition

    NASA Astrophysics Data System (ADS)

    Halliday, David; Resnick, Robert; Walker, Jearl

    2004-06-01

    No other book on the market today can match the 30-year success of Halliday, Resnick and Walker's Fundamentals of Physics! Fundamentals of Physics, 7th Edition and the Extended Version, 7th Edition offer a solid understanding of fundamental physics concepts, helping readers apply this conceptual understanding to quantitative problem solving, in a breezy, easy-to-understand style. A unique combination of authoritative content and stimulating applications. * Numerous improvements in the text, based on feedback from the many users of the sixth edition (both instructors and students) * Several thousand end-of-chapter problems have been rewritten to streamline both the presentations and answers * 'Chapter Puzzlers' open each chapter with an intriguing application or question that is explained or answered in the chapter * Problem-solving tactics are provided to help beginning Physics students solve problems and avoid common error * The first section in every chapter introduces the subject of the chapter by asking and answering, "What is Physics?" as the question pertains to the chapter * Numerous supplements available to aid teachers and students The extended edition provides coverage of developments in Physics in the last 100 years, including: Einstein and Relativity, Bohr and others and Quantum Theory, and the more recent theoretical developments like String Theory.

  20. RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation.

    PubMed Central

    Hanrahan, C J; Palladino, M J; Ganetzky, B; Reenan, R A

    2000-01-01

    Post-transcriptional editing of pre-mRNAs through the action of dsRNA adenosine deaminases results in the modification of particular adenosine (A) residues to inosine (I), which can alter the coding potential of the modified transcripts. We describe here three sites in the para transcript, which encodes the major voltage-activated Na(+) channel polypeptide in Drosophila, where RNA editing occurs. The occurrence of RNA editing at the three sites was found to be developmentally regulated. Editing at two of these sites was also conserved across species between the D. melanogaster and D. virilis. In each case, a highly conserved region was found in the intron downstream of the editing site and this region was shown to be complementary to the region of the exonic editing site. Thus, editing at these sites would appear to involve a mechanism whereby the edited exon forms a base-paired secondary structure with the distant conserved noncoding sequences located in adjacent downstream introns, similar to the mechanism shown for A-to-I RNA editing of mammalian glutamate receptor subunits (GluRs). For the third site, neither RNA editing nor the predicted RNA secondary structures were evolutionarily conserved. Transcripts from transgenic Drosophila expressing a minimal editing site construct for this site were shown to faithfully undergo RNA editing. These results demonstrate that Na(+) channel diversity in Drosophila is increased by RNA editing via a mechanism analogous to that described for transcripts encoding mammalian GluRs. PMID:10880477

  1. United States Army, Sixth Army Field Order 74

    DTIC Science & Technology

    1945-01-01

    Sixth Amy Reserve; _!. llth Airborne Division: a.. Commander: -Major General Joseph M. Swing,’U.S.A. b_. Units and Staging: Annex 3h_« (i) Army...HEADQUARTERS SIXTH AMY . APO-442 - 19301 28 July 1945 ANNEX 3f to FO 74 , Troop List, 40th Infantry Division, reinforced (tentative) COMBAT UNITS Unit 40th’ inf...route SHIBUSHI - KA3DYA - TAKASU. • (4) The 281st signal Pigeon Compan;,’- will: (a) provide I, IX, and XI Corps-with, one combat section each prior to

  2. 12th Annual School Construction Report, 2007

    ERIC Educational Resources Information Center

    Abramson, Paul

    2007-01-01

    School construction completed in 2006 totaled just more than $20 billion, a drop of seven percent from the record $21.6 billion put in place in 2005. Even so, it was the sixth year in the last seven that annual construction exceeded $20 billion. During the seven years of the present century, school districts have completed construction projects…

  3. "...If We Were Cavemen We'd Be Fine": Facebook as a Catalyst for Critical Literacy Learning by Dyslexic Sixth-Form Students

    ERIC Educational Resources Information Center

    Barden, Owen

    2012-01-01

    This article is derived from a study of the use of Facebook as an educational resource by five dyslexic students at a sixth form college in north-west England. Through a project in which teacher-researcher and student-participants co-constructed a group Facebook page about the students' scaffolded research into dyslexia, the study examined the…

  4. Sixth Grade Outdoor Education Program. Outdoor Curriculum Guide.

    ERIC Educational Resources Information Center

    Densmore, Tom, Comp.; And Others

    Compiled for teachers whose sixth grade students participate in the resident camping program of the Dixon Public Schools (Dixon, Illinois), this guide offers extensive and detailed information for use in planning the camp curriculum. Activities are suggested for environmental study, group socialization, and recreation. Environmental study units…

  5. DETAIL OF AN EXTERNAL TANK SUPPORT ARM, SIXTH LEVEL OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF AN EXTERNAL TANK SUPPORT ARM, SIXTH LEVEL OF THE EXTERNAL TANK CHECK-OUT CELLS, HB-2, FACING NORTHEAST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  6. Netbooks in Sixth-Grade English Language Classrooms

    ERIC Educational Resources Information Center

    Lin, Janet Mei-Chuen; Wu, Yi-Jiun

    2010-01-01

    As netbook computers are becoming an attractive option for K-12 educators, they have the potential to be a more integral part of language learning. In this study 45 sixth graders in two classes used netbooks to learn English as a second language. Forty-four students in two other classes served as the control group who received traditional…

  7. The Teaching of Electromagnetic Induction at Sixth Form Level

    ERIC Educational Resources Information Center

    Archenhold, W. F.

    1974-01-01

    Presents some ideas about teaching electromagnetic induction at sixth form level, including educational objectives, learning difficulties, syllabus requirements, selection of unit system, and sequence of material presentation. Suggests the Education Group of the Institute of Physics hold further discussions on these aspects before including the…

  8. VIEW OF THE EAST CHECKOUT CELL, SIXTH LEVEL OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE EAST CHECK-OUT CELL, SIXTH LEVEL OF THE EXTERNAL TANK CHECK-OUT CELLS, HB-2, FACING NORTHEAST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  9. VIEW OF THE WEST CHECKOUT CELL, SIXTH LEVEL OF THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE WEST CHECK-OUT CELL, SIXTH LEVEL OF THE EXTERNAL TANK CHECK-OUT CELLS, HB-2, FACING NORTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

  10. Dear Cesar Chavez: Writing Persuasive Letters in the Sixth Grade

    ERIC Educational Resources Information Center

    Beddow, Maggie

    2012-01-01

    Cesar Chavez, who co-founded the United Farm Workers (UFW) with Dolores Huerta in 1962, dedicated his life to grassroots organizing to persuade lawmakers and the public to help improve the working conditions of migrant farm workers. In October 1992, the author had been teaching a unit of study on civics to her sixth grade bilingual students in…

  11. An Ecological Energetics Field Course for Sixth Forms.

    ERIC Educational Resources Information Center

    Wells, Phillip

    1982-01-01

    Describes a sixth-form field course consisting of written materials for students and a teacher's booklet giving necessary techniques, lists of apparatus, and practical hints. The course aims to estimate energy flows in a woodland ecosystem by means of a series of practical sessions involving field/laboratory investigations and calculations.…

  12. Eating Attitudes in Fourth-, Sixth-, and Eighth-Grade Girls.

    ERIC Educational Resources Information Center

    Rhyne-Winkler, Martha C.

    1994-01-01

    Examined eating attitudes of fourth-, sixth-, and eighth-grade girls (n=379) and relationship between those attitudes and achievement scores, school ability, absenteeism, family income, grade level, family size, age, height/weight ratio, diet history, weight satisfaction, appearance satisfaction, and school anxiety. Found that eating-disordered…

  13. Western deck plate girder span of Bridge No. 1413, Sixth ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Western deck plate girder span of Bridge No. 1413, Sixth Potomac Crossing, passing over MD 51, with "WESTERN MARYLAND RAILWAY" painted on the girder panels, looking northwest. - Western Maryland Railway, Cumberland Extension, Pearre to North Branch, from WM milepost 125 to 160, Pearre, Washington County, MD

  14. 25. SIXTH FLOOR BLDG. 28B LOOKING EAST. Fafnir Bearing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. SIXTH FLOOR BLDG. 28B LOOKING EAST. - Fafnir Bearing Plant, Bounded on North side by Myrtle Street, on South side by Orange Street, on East side by Booth Street & on West side by Grove Street, New Britain, Hartford County, CT

  15. Melissa's Year in Sixth Grade: A Technology Integration Vignette.

    ERIC Educational Resources Information Center

    Hemmer, Jeanie

    1998-01-01

    In 1995, rather than require seventh-grade computer literacy classes, Texas allowed school districts to integrate technology skills into curricula. This article, the first of three, describes technology integration for sixth grade. Includes unit ideas on nations; the Holocaust; Olympic diving; Christmas; probability; organisms; Antarctica;…

  16. Sixth-Form Projects in Biology: A Case History.

    ERIC Educational Resources Information Center

    Robinson, P. M.; Parker, R. E.

    1981-01-01

    Some of the problems encountered in devising sixth-form projects are discussed and a detailed account given of one project in which a study was made of the effect of onion bulb volatiles on the germination of lettuce seed. (Author)

  17. Computers and Problem Solving for Sixth-Grade.

    ERIC Educational Resources Information Center

    Oughton, John M.

    1995-01-01

    Presents a curriculum unit designed for average sixth-grade students intended to engage them in problem-solving experiences and to teach them problem-solving strategies. The curriculum consists of 20 sessions in which students engage in various activities using the following software packages: The Adventures of Jasper Woodbury, Rescue at Boone's…

  18. African Unit. An Instructional Unit for Sixth Grade.

    ERIC Educational Resources Information Center

    Lewis, Elaine

    This teaching guide presents objectives, activities, pre and posttests, and handouts to help sixth grade classroom teachers as they develop and implement educational programs about Africa. The major purpose is to help students develop positive attitudes toward other cultures, particularly African cultures. Specific objectives are to help students…

  19. 87. SIXTH FLOOR BLDG. 19 "CLEAN ROOM" LOOKING WEST. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    87. SIXTH FLOOR BLDG. 19 "CLEAN ROOM" LOOKING WEST. - Fafnir Bearing Plant, Bounded on North side by Myrtle Street, on South side by Orange Street, on East side by Booth Street & on West side by Grove Street, New Britain, Hartford County, CT

  20. Perspectives on the Teaching of Mathematics (Sixty-Sixth Yearbook)

    ERIC Educational Resources Information Center

    Rubenstein, Rheta N., Ed.; Bright, George W., Ed.

    2004-01-01

    Teaching is a complex, ongoing endeavor that involves a myriad of decisions. NCTM's Sixty-Sixth Yearbook is organized around three aspects of teaching: foundations for teaching, the enactment of teaching, and the support of teaching nurtured in preservice education and strengthened throughout a teacher's career. The accompanying professional…

  1. The People of the Soviet Union. Sixth Grade.

    ERIC Educational Resources Information Center

    Reikofski, Joyce

    This sixth grade teaching unit covers Soviet propaganda, communism, relations with the United States, Soviet geography, Soviet arts, and Soviet life. Unit goals address the above content areas, map skills, and an attitudinal goal of helping students to develop a sense of respect for the life of Soviet citizens. Behavioral objectives are keyed to…

  2. Sights, Sounds, Senses in Step with Reading. Sixth Grade.

    ERIC Educational Resources Information Center

    Norris, Mildred W.; Messerli, John H.

    This ESEA Title III bibliography presents books, films, filmstrips, and records that can be used on the sixth-grade level. The list of books is prepared from the suggested lists of the Ginn, Houghton Mifflin, Lippincott, and Scott, Foresman reading series. The bibliography includes sections about animals, poetry, fiction, science fiction,…

  3. Speculation and Historical Interpretation for Fifth and Sixth Graders.

    ERIC Educational Resources Information Center

    Schneider, Elizabeth; Gregory, Leslie A.

    2000-01-01

    Describes a unit for fifth- and sixth-grade students that helps develop critical thinking skills. Explains that students read the book, "Leonardo da Vinci" (Diane Stanley), to develop their historical interpretation skills and demonstrate that there is not just one right answer in history. (CMK)

  4. [Sixth nerve palsies in children. Presentation of four cases].

    PubMed

    Zimmermann-Paiz, Martin A; Fang-Sung, Jen Wen

    2008-10-01

    The etiology of the sixth nerve palsy in children includes multiple causes, being the acquired ones the most frequent. Due to the importance of the adequate management and possible implications of this pathology, four patients are presented for analysis and discussion.

  5. 132. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, ROOM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    132. INTERIOR, SIXTH FLOOR, WING 6100 WEST, SUITE 6000, ROOM 6156, OFFICE OF THE SECRETARY OF THE INTERIOR, PLASTER CEILING MEDALLION AND BRONZE CHANDELIER (4' x 5' negative; 8' x 10' print) - U.S. Department of the Interior, Eighteenth & C Streets Northwest, Washington, District of Columbia, DC

  6. Sixth-Form Colleges: An Endangered Organisational Form?

    ERIC Educational Resources Information Center

    Stoten, David William

    2014-01-01

    The sixth-form college sector is often marginalised in policy and academic discourse, where the much larger school and further education sectors dominate. This paper sets out to describe the sector's key features, assess its position within the wider education system and consider its future in an increasingly competitive education market. The…

  7. Joint Confirmatory Factor Analysis of the Woodcock-Johnson Tests of Cognitive Abilities, Third Edition, and the Stanford-Binet Intelligence Scales, Fifth Edition, with a Preschool Population

    ERIC Educational Resources Information Center

    Chang, Mei; Paulson, Sharon E.; Finch, W. Holmes; Mcintosh, David E.; Rothlisberg, Barbara A.

    2014-01-01

    This study examined the underlying constructs measured by the Woodcock-Johnson Tests of Cognitive Abilities, Third Edition (WJ-III COG) and the Stanford-Binet Intelligence Scales, Fifth Edition (SB5), based on the Cattell-Horn-Carrol (CHC) theory of cognitive abilities. This study reports the results of the first joint confirmatory factor analysis…

  8. Authoritative Online Editions

    ERIC Educational Resources Information Center

    Benton, Thomas H.

    2007-01-01

    In this article, the author discusses how it is now very easy for anyone to find formerly hard-to-find books such as the works of Walt Whitman with the help of online booksellers. The author also describes the efforts made by various institutions to produce online editions of the works of major writers. One such prominent project is the archive…

  9. Aerospace Bibliography, Third Edition.

    ERIC Educational Resources Information Center

    National Aeronautics and Space Administration, Washington, DC.

    This third edition bibliography lists books and teaching aids related to aeronautics and space. Aeronautics titles are limited to aerospace-related research subjects, and books on astronomy to those directly related to space exploration. Also listed are pertinent references like pamphlets, films, film strips, booklets, charts, pictures,…

  10. Beginning to edit physics

    SciTech Connect

    Murphy, P.W.

    1995-02-01

    A physicist-turned-editor shows you the basics required for copyediting physics papers (physical quantities, symbols, units, scientific notation, the structure of mathematical expressions, the nature of graphs), and points the way to learning enough ``editorial physics`` to begin substantive editing.

  11. MENTAL DEFICIENCY. SECOND EDITION.

    ERIC Educational Resources Information Center

    HILLIARD, L.T.; KIRMAN, BRIAN H.

    REVISED TO INCLUDE LEGISLATIVE AND ADMINISTRATIVE PROCEDURES NEW IN BRITAIN SINCE THE 1957 EDITION, THE TEXT INCLUDES RECENT ADVANCES IN ETIOLOGY, PATHOLOGY, AND TREATMENT OF MENTAL DEFICIENCY. CONSIDERATION OF THE BACKGROUND OF MENTAL DEFICIENCY INCLUDES HISTORICAL AND LEGAL ASPECTS, THE SOCIAL BACKGROUND OF MENTAL DEFECT, PRENATAL CAUSES OF…

  12. Headlines Previous Editions

    Science.gov Websites

    Previous Editions: Volume 17 Volume 16 Volume 15 Volume 14 Volume 13 FEB 2017 JAN 2017 DEC 2016 NOV 2016 OCT 2016 SEP 2016 AUG 2016 JUL 2016 JUN 2016 MAY 2016 APR 2016 MAR 2016 FEB ...

  13. 77 FR 8325 - Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium Batteries and Battery Systems...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... TRANSPORTATION Federal Aviation Administration Sixth Meeting: RTCA Special Committee 225, Rechargeable Lithium.... Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 225, Rechargeable Lithium... public of the sixth meeting of RTCA Special Committee 225, Rechargeable Lithium Batteries and...

  14. Pre-Service Elementary Teachers' Mathematics Content Knowledge: A Predictor of Sixth Graders' Mathematics Performance

    ERIC Educational Resources Information Center

    Shirvani, Hosin

    2015-01-01

    This study examined the knowledge of mathematics content of elementary pre-service teachers at a sixth grade level. The researcher administered a mathematics test for sixth graders mandated by the Texas Education Agency to pre-service teachers; the same test was given to sixth graders in Texas. The study found that pre-service teachers performed…

  15. 2. TYPICAL OVERHEAD WIRE CONSTRUCTION CURVE GUY WIRE ARRANGEMENT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. TYPICAL OVERHEAD WIRE CONSTRUCTION - CURVE GUY WIRE ARRANGEMENT (ABANDONED WEST LEG OF WYE AT SIXTH AVENUE AND PINE STREET) - Yakima Valley Transportation Company Interurban Railroad, Trackage, Yakima, Yakima County, WA

  16. [From random mutagenesis to precise genome editing: the development and evolution of genome editing techniques in Drosophila].

    PubMed

    Su, Fang; Huang, Zongliang; Guo, Yawen; Jiao, Renjie; Zi, Li; Chen, Jianming; Liu, Jiyong

    2016-01-01

    Drosophila melanogaster, an important model organism for studying life science, has contributed more to the research of genetics, developmental biology and biomedicine with the development of genome editing techniques. Drosophila genome-editing techniques have evolved from random mutagenesis to precise genome editing and from simple mutant construction to diverse genome editing methods since the 20th century. Chemical mutagenesis, using Ethyl methanesulfonate (EMS), is an important technique to study gene function in forward genetics, however, the precise knockout of Drosophila genes could not be achieved. The gene targeting technology, based on homologous recombination, has accomplished the precise editing of Drosophila genome for the first time, but with low efficiency. The CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein)-mediated precise genome editing is simple, fast and highly efficient compared with the gene targeting technology in Drosophila. In this review, we focus on Drosophila gene knockout, and summarize the evolution of genome editing techniques in Drosophila, emphasizing the development and applications of gene targeting, zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and CRISPR/Cas9 techniques.

  17. Coal production and transportation: sixth annual conference, 1980

    SciTech Connect

    Not Available

    1980-01-01

    The Sixth Annual Conference, Coal Production and Transportation was held April 2-3, 1980 at the Fairmont Hotel, San Francisco, CA. It was sponsored by PLM, Inc. The papers involved mainly: coal's future, EPRI's projection of electrical energy, coal transport on land and on sea, coal car design and manufacturing, and a review of synthetic fuels and coal gasification. Fourteen papers have been entered individually into EDB and ERA. (LTN)

  18. The Sixth Annual Thermal and Fluids Analysis Workshop

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Sixth Annual Thermal and Fluids Analysis Workshop consisted of classes, vendor demonstrations, and paper sessions. The classes and vendor demonstrations provided participants with the information on widely used tools for thermal and fluids analysis. The paper sessions provided a forum for the exchange of information and ideas among thermal and fluids analysis. Paper topics included advances an uses of established thermal and fluids computer codes (such as SINDA and TRASYS) as well as unique modeling techniques and applications.

  19. Sixth blind test of organic crystal-structure prediction methods.

    PubMed

    Groom, Colin R; Reilly, Anthony M

    2014-08-01

    Over the past 15 years progress in predicting crystal structures of small organic molecules has been charted by a series of blind tests hosted by the Cambridge Crystallographic Data Centre. This letter announces a sixth blind test to take place between September 2014 and August 2015, giving details of the target systems and the revised procedure. We hope that as many methods as possible will be assessed and benchmarked in this new blind test.

  20. 5. VIEW LOOKING SOUTH DOWN SIXTH STREET AT THE INTERSECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW LOOKING SOUTH DOWN SIXTH STREET AT THE INTERSECTION WITH CENTRAL AVENUE. AS PART OF THE INITIAL SITE DEVELOPMENT, A RAILROAD SPUR, ACCESS ROADS, POWER LINES, AND TELEPHONE LINES WERE BUILT. ALL FACILITIES WERE HEATED BY STEAM GENERATED IN BUILDING 443 AND PIPED THROUGHOUT THE SITE. THE BUILDING IN THE BACKGROUND OF THE PHOTOGRAPH IS BUILDING 664, A LOW - LEVEL WASTE STORAGE FACILITY. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  1. Comparing Science Achievement Constructs: Targeted and Achieved

    ERIC Educational Resources Information Center

    Ferrara, Steve; Duncan, Teresa

    2011-01-01

    This article illustrates how test specifications based solely on academic content standards, without attention to other cognitive skills and item response demands, can fall short of their targeted constructs. First, the authors inductively describe the science achievement construct represented by a statewide sixth-grade science proficiency test.…

  2. The Health of the Public Charter School Movement: A State-by-State Analysis. Second Edition

    ERIC Educational Resources Information Center

    Ziebarth, Todd; Bierlein Palmer, Louann

    2016-01-01

    In October 2014, the first edition of "The Health of the Public Charter School Movement: A State-by-State Analysis" was released. Both encouraging words and constructive criticism for how to improve the report going forward were received. This second edition builds on the solid foundation of the inaugural version, while making…

  3. REDIdb: the RNA editing database.

    PubMed

    Picardi, Ernesto; Regina, Teresa Maria Rosaria; Brennicke, Axel; Quagliariello, Carla

    2007-01-01

    The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by experimental inspection (in vitro) or by computational detection (in silico). Each record of REDIdb is organized in a specific flat-file containing a description of the main characteristics of the entry, a feature table with the editing events and related details and a sequence zone with both the genomic sequence and the corresponding edited transcript. REDIdb is a relational database in which the browsing and identification of editing sites has been simplified by means of two facilities to either graphically display genomic or cDNA sequences or to show the corresponding alignment. In both cases, all editing sites are highlighted in colour and their relative positions are detailed by mousing over. New editing positions can be directly submitted to REDIdb after a user-specific registration to obtain authorized secure access. This first version of REDIdb database stores 9964 editing events and can be freely queried at http://biologia.unical.it/py_script/search.html.

  4. Exposure Factors Handbook (2011 Edition)

    EPA Pesticide Factsheets

    Exposure Factors Handbook: 2011 Edition. The Exposure Factors Handbook provides information on various physiological and behavioral factors commonly used in assessing exposure to environmental chemicals.

  5. Genetic map of Salmonella typhimurium, edition VIII.

    PubMed Central

    Sanderson, K E; Hessel, A; Rudd, K E

    1995-01-01

    We present edition VIII of the genetic map of Salmonella typhimurium LT2. We list a total of 1,159 genes, 1,080 of which have been located on the circular chromosome and 29 of which are on pSLT, the 90-kb plasmid usually found in LT2 lines. The remaining 50 genes are not yet mapped. The coordinate system used in this edition is neither minutes of transfer time in conjugation crosses nor units representing "phage lengths" of DNA of the transducing phage P22, as used in earlier editions, but centisomes and kilobases based on physical analysis of the lengths of DNA segments between genes. Some of these lengths have been determined by digestion of DNA by rare-cutting endonucleases and separation of fragments by pulsed-field gel electrophoresis. Other lengths have been determined by analysis of DNA sequences in GenBank. We have constructed StySeq1, which incorporates all Salmonella DNA sequence data known to us. StySeq1 comprises over 548 kb of nonredundant chromosomal genomic sequences, representing 11.4% of the chromosome, which is estimated to be just over 4,800 kb in length. Most of these sequences were assigned locations on the chromosome, in some cases by analogy with mapped Escherichia coli sequences. PMID:7603411

  6. Genome editing for human gene therapy.

    PubMed

    Meissner, Torsten B; Mandal, Pankaj K; Ferreira, Leonardo M R; Rossi, Derrick J; Cowan, Chad A

    2014-01-01

    The rapid advancement of genome-editing techniques holds much promise for the field of human gene therapy. From bacteria to model organisms and human cells, genome editing tools such as zinc-finger nucleases (ZNFs), TALENs, and CRISPR/Cas9 have been successfully used to manipulate the respective genomes with unprecedented precision. With regard to human gene therapy, it is of great interest to test the feasibility of genome editing in primary human hematopoietic cells that could potentially be used to treat a variety of human genetic disorders such as hemoglobinopathies, primary immunodeficiencies, and cancer. In this chapter, we explore the use of the CRISPR/Cas9 system for the efficient ablation of genes in two clinically relevant primary human cell types, CD4+ T cells and CD34+ hematopoietic stem and progenitor cells. By using two guide RNAs directed at a single locus, we achieve highly efficient and predictable deletions that ablate gene function. The use of a Cas9-2A-GFP fusion protein allows FACS-based enrichment of the transfected cells. The ease of designing, constructing, and testing guide RNAs makes this dual guide strategy an attractive approach for the efficient deletion of clinically relevant genes in primary human hematopoietic stem and effector cells and enables the use of CRISPR/Cas9 for gene therapy.

  7. Sixth International Conference on X-ray Microscopy

    SciTech Connect

    Robinson, Arthur L.

    1999-08-23

    More than 180 participants from around the world crowded the Clark Kerr Campus of the University of California, Berkeley, from August 1-6, 1999 for the Sixth International Conference on X-Ray Microscopy (XRM99). Held every three years since 1983, the XRM conferences have become the primary international forum for the presentation and discussion of advances in high-spatial-resolution x-ray imaging and applications (including the use of x-ray spectroscopic and analytical techniques) in biological and medical sciences, environmental and soil sciences, and materials and surface sciences.

  8. Has the Earth's sixth mass extinction already arrived?

    PubMed

    Barnosky, Anthony D; Matzke, Nicholas; Tomiya, Susumu; Wogan, Guinevere O U; Swartz, Brian; Quental, Tiago B; Marshall, Charles; McGuire, Jenny L; Lindsey, Emily L; Maguire, Kaitlin C; Mersey, Ben; Ferrer, Elizabeth A

    2011-03-03

    Palaeontologists characterize mass extinctions as times when the Earth loses more than three-quarters of its species in a geologically short interval, as has happened only five times in the past 540 million years or so. Biologists now suggest that a sixth mass extinction may be under way, given the known species losses over the past few centuries and millennia. Here we review how differences between fossil and modern data and the addition of recently available palaeontological information influence our understanding of the current extinction crisis. Our results confirm that current extinction rates are higher than would be expected from the fossil record, highlighting the need for effective conservation measures.

  9. Text Editing in Chemistry Instruction.

    ERIC Educational Resources Information Center

    Ngu, Bing Hiong; Low, Renae; Sweller, John

    2002-01-01

    Describes experiments with Australian high school students that investigated differences in performance on chemistry word problems between two learning strategies: text editing, and conventional problem solving. Concluded that text editing had no advantage over problem solving in stoichiometry problems, and that the suitability of a text editing…

  10. Graphic Arts: Orientation, Composition, and Paste-Up. Fourth Edition. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Licklider, Cheryl

    This teacher and student edition, the first in a series of instructional materials on graphic communication, consists of orientation information, teacher pages, and student worksheets. The teacher edition contains these introductory pages: use of this publication; training and competency profile; PrintED crosswalk; instructional/task analysis;…

  11. Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    ERIC Educational Resources Information Center

    Knapp, John; Harper, Eddie

    This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

  12. Introduction to Surgical Technology. Third Edition. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Bushey, Vicki; Hildebrand, Bob; Hildebrand, Dinah; Johnson, Dave; Sikes, John; Tahah, Ann; Walker, Susan; Zielsdorf, Lani

    These teacher and student editions provide instructional materials for an introduction to surgical technology course. Introductory materials in the teacher edition include information on use, instructional/task analysis, academic and workplace skill classifications and definitions, related academic and workplace skill list, and crosswalk to…

  13. Graphic Arts: Process Camera, Stripping, and Platemaking. Fourth Edition. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Multistate Academic and Vocational Curriculum Consortium, Stillwater, OK.

    This publication contains both a teacher edition and a student edition of materials for a course in graphic arts that covers the process camera, stripping, and platemaking. The course introduces basic concepts and skills necessary for entry-level employment in a graphic communication occupation. The contents of the materials are tied to measurable…

  14. Residential and Light Commercial HVAC. Teacher Edition and Student Edition. Second Edition.

    ERIC Educational Resources Information Center

    Stephenson, David

    This package contains teacher and student editions of a residential and light commercial heating, ventilation, and air conditioning (HVAC) course of study. The teacher edition contains information on the following: using the publication; national competencies; competency profile; related academic and workplace skills list; tools, equipment, and…

  15. Fundamentals of Welding. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    ERIC Educational Resources Information Center

    Fortney, Clarence; Gregory, Mike; New, Larry

    Teacher and student editions and a student workbook for fundamentals of welding comprise the first of six in a series of competency-based instructional materials for welding programs. Introductory pages in the teacher edition are training and competency profile, instructional/task analysis, basic skills icons and classifications, basic skills…

  16. Infant Stimulation Curriculum. Revised Edition.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Herschel W. Nisonger Center.

    Presented is the Infant Stimulation Curriculum (developed by the Developmentally Delayed Infant Outreach Project) for parents and teachers to use with children who are developmentally between birth and 36 months of age. Published in a card format at a sixth grade readability level, the curriculum includes introductory cards providing information…

  17. Requirements for Certification of Teachers, Counselors, Librarians, Administrators for Elementary and Secondary Schools. Seventy-Sixth Edition, 2011-2012

    ERIC Educational Resources Information Center

    Kaye, Elizabeth A., Ed.

    2011-01-01

    This annual volume offers the most complete and current listings of the requirements for certification of a wide range of educational professionals at the elementary and secondary levels. "Requirements for Certification" is a valuable resource, making much-needed knowledge available in one straightforward volume. [For "Requirements…

  18. School Health in America: An Assessment of State Policies To Protect and Improve the Health of Students. Sixth Edition.

    ERIC Educational Resources Information Center

    American School Health Association, Kent, OH.

    This report presents state-level data collected by mail from March-June 1994 via the School Health Program and Policies Study, which was designed to measure success in meeting school-specific items among the Healthy People 2000 national objectives as well as one of the National Education Goals. Five chapters on health education, health services,…

  19. Alternatives to the Peace Corps: A Directory of Third World & U.S. Volunteer Opportunities. Sixth Edition.

    ERIC Educational Resources Information Center

    Olson, Annette, Ed.

    Some returned Peace Corps volunteers believe that U.S. foreign policy has been more damaging than helpful in the Third World. They question the links between U.S. foreign and military policy and the Peace Corps. This book addresses such questions and brings together resources and information that will help the prospective volunteer find an…

  20. High Interest--Easy Reading: A Booklist for Junior and Senior High School Students. Sixth Edition. NCTE Bibliography Series.

    ERIC Educational Resources Information Center

    McBride, William G., Ed.

    Designed to encourage students in grades 7-12 to make reading a habit, this annotated booklist contains over 400 titles of fiction and nonfiction books published between 1987 and 1989. It is intended for students who are able to read but lack the motivation to do so because they have not encountered books that speak to their interests and…

  1. The Playing Field. A Curriculum Guide to Pesticide Education for Fourth, Fifth, and Sixth Grades. First Edition.

    ERIC Educational Resources Information Center

    Bellissemo, Diane; Garcia, Deliana

    A pesticide safety video for children 9-12 years old, "The Playing Field," draws children into the lives of a migrant farmworker family while teaching them about the dangers of pesticides. The video and the lessons are not limited to migrant education, but open a multicultural window for all children, migrant or nonmigrant. Teaching elements for…

  2. Biological Science: An Ecological Approach. BSCS Green Version. Teacher's Resource Book and Test Item Bank. Sixth Edition.

    ERIC Educational Resources Information Center

    Biological Sciences Curriculum Study, Colorado Springs.

    This book consists of four sections: (1) "Supplemental Materials"; (2) "Supplemental Investigations"; (3) "Test Item Bank"; and (4) "Blackline Masters." The first section provides additional background material related to selected chapters and investigations in the student book. Included are a periodic table of the elements, genetics problems and…

  3. Energy Support for Global Missions. Defense Energy Support Center Fact Book, Fiscal Year 2003, Twenty-Sixth Edition

    DTIC Science & Technology

    2003-01-01

    Research and Analysis Office. Contract prices are adjusted upward or downward as indicators rise or fall. DESC pays the contract price in effect on the...adjustment clauses. Contract prices are indexed to market price indicators. All indicators are carefully selected and tested by the DESC Market

  4. Tools of Radio Astronomy, 5th edition

    NASA Astrophysics Data System (ADS)

    Wilson, Thomas L.; Rohlfs, Kristian; Huttemeister, Susanne

    2012-12-01

    New 5th corrected edition of the book http://adsabs.harvard.edu/abs/2009tra..book.....W in Russian, translated by O. Verkhodanov and S. Trushkin, editing S.A. Trushkin from Special astrophysical observatory RAS. This edition contains the translation of the 5th Springer edition of 2009 and new additional chapter (wrote by authors) of Solutions of the problems.

  5. An Assessment of Computerized Text Editing Programs.

    ERIC Educational Resources Information Center

    Scheibal, William J.; Kohut, Gary F.

    1991-01-01

    Addresses the question of whether text editing programs are successful in taking over the traditional functions of an editor. Compares the editing suggestions made by two of the most popular text editing programs ("RightWriter" and "Punctuation + Style") with those of an experienced editor. Finds that text editing programs are…

  6. When genres meet: Inquiry into a sixth-grade urban science class

    NASA Astrophysics Data System (ADS)

    Varelas, Maria; Becker, Joe; Luster, Barbara; Wenzel, Stacy

    2002-09-01

    In this study, we explore oral and written work (plays and rap songs) of students in a sixth-grade all African-American urban science class to reveal ways affective and social aspects are intertwined with students' cognition. We interpret students' work in terms of the meeting of various genres brought by the students and teachers to the classroom. Students bring youth genres, classroom genres that they have constructed from previous schooling, and perhaps their own science genres. Teachers bring their favored classroom and science genres. We show how students' affective reactions were an integral part of their constructed scientific knowledge. Their knowledge building emerged as a social process involving a range of transactions among students and between students and teacher, some transactions being relatively smooth and others having more friction. Along with their developing science genre, students portrayed elements of classroom genres that did not exist in the classroom genre that the teacher sought to bring to the class. Students' work offered us a glimpse of students' interpretations of gender dynamics in their classrooms. Gender also was related to the particular ways that students in that class included disagreement in their developing science genre.

  7. ICENES '91:Sixth international conference on emerging nuclear energy systems

    SciTech Connect

    Not Available

    1991-01-01

    This document contains the program and abstracts of the sessions at the Sixth International Conference on Emerging Nuclear Energy Systems held June 16--21, 1991 at Monterey, California. These sessions included: The plenary session, fission session, fission and nonelectric session, poster session 1P; (space propulsion, space nuclear power, electrostatic confined fusion, fusion miscellaneous, inertial confinement fusion, [mu]-catalyzed fusion, and cold fusion); Advanced fusion session, space nuclear session, poster session 2P, (nuclear reactions/data, isotope separation, direct energy conversion and exotic concepts, fusion-fission hybrids, nuclear desalting, accelerator waste-transmutation, and fusion-based chemical recycling); energy policy session, poster session 3P (energy policy, magnetic fusion reactors, fission reactors, magnetically insulated inertial fusion, and nuclear explosives for power generation); exotic energy storage and conversion session; and exotic energy storage and conversion; review and closing session.

  8. Sixth Microgravity Fluid Physics and Transport Phenomena Conference Abstracts

    NASA Technical Reports Server (NTRS)

    Singh, Bhim (Compiler)

    2002-01-01

    The Sixth Microgravity Fluid Physics and Transport Phenomena Conference provides the scientific community the opportunity to view the current scope of the Microgravity Fluid Physics and Transport Phenomena Program, current research opportunities, and plans for the near future. The conference focuses not only on fundamental research but also on applications of this knowledge towards enabling future space exploration missions. A whole session dedicated to biological fluid physics shows increased emphasis that the program has placed on interdisciplinary research. The conference includes invited plenary talks, technical paper presentations, poster presentations, and exhibits. This TM is a compilation of abstracts of the papers and the posters presented at the conference. Web-based proceedings, including the charts used by the presenters, will be posted on the web shortly after the conference.

  9. Identifying features in biological sequences: Sixth workshop report

    SciTech Connect

    Burks, C.; Myers, E.; Pearson, W.R.

    1995-12-31

    This report covers the sixth of an annual series of workshops held at the Aspen Center for Physics concentrating particularly on the identification of features in DNA sequence, and more broadly on related topics in computational molecular biology. The workshop series originally focused primarily on discussion of current needs and future strategies for identifying and predicting the presence of complex functional units on sequenced, but otherwise uncharacterized, genomic DNA. We addressed the need for computationally-based, automatic tools for synthesizing available data about individual consensus sequences and local compositional patterns into the composite objects (e.g., genes) that are -- as composite entities -- the true object of interest when scanning DNA sequences. The workshop was structured to promote sustained informal contact and exchange of expertise between molecular biologists, computer scientists, and mathematicians.

  10. The Sixth Copper Mountain Conference on Multigrid Methods, part 2

    NASA Technical Reports Server (NTRS)

    Melson, N. Duane (Editor); Mccormick, Steve F. (Editor); Manteuffel, Thomas A. (Editor)

    1993-01-01

    The Sixth Copper Mountain Conference on Multigrid Methods was held on April 4-9, 1993, at Copper Mountain, Colorado. This book is a collection of many of the papers presented at the conference and so represents the conference proceedings. NASA Langley graciously provided printing of this document so that all of the papers could be presented in a single forum. Each paper was reviewed by a member of the conference organizing committee under the coordination of the editors. The multigrid discipline continues to expand and mature, as is evident from these proceedings. The vibrancy in this field is amply expressed in these important papers, and the collection clearly shows its rapid trend to further diversity and depth.

  11. A report from the Sixth International Mouse Genome Conference

    SciTech Connect

    Brown, S.

    1992-12-31

    The Sixth Annual Mouse Genome Conference was held in October, 1992 at Buffalo, USA. The mouse is one of the primary model organisms in the Human Genome Project. Through the use of gene targeting studies the mouse has become a powerful biological model for the study of gene function and, in addition, the comparison of the many homologous mutations identified in human and mouse have widened our understanding of the biology of these two organisms. A primary goal in the mouse genome program has been to create a genetic map of STSs of high resolution (<1cM) that would form the basis for the physical mapping of the whole mouse genome. Buffalo saw substantial new progress towards the goal of a very high density genetic map and the beginnings of substantive efforts towards physical mapping in chromosome regions with a high density of genetic markers.

  12. The Sixth Copper Mountain Conference on Multigrid Methods, part 1

    NASA Technical Reports Server (NTRS)

    Melson, N. Duane (Editor); Manteuffel, T. A. (Editor); Mccormick, S. F. (Editor)

    1993-01-01

    The Sixth Copper Mountain Conference on Multigrid Methods was held on 4-9 Apr. 1993, at Copper Mountain, CO. This book is a collection of many of the papers presented at the conference and as such represents the conference proceedings. NASA LaRC graciously provided printing of this document so that all of the papers could be presented in a single forum. Each paper was reviewed by a member of the conference organizing committee under the coordination of the editors. The multigrid discipline continues to expand and mature, as is evident from these proceedings. The vibrancy in this field is amply expressed in these important papers, and the collection clearly shows its rapid trend to further diversity and depth.

  13. The Sixth Omega Laser Facility Users Group Workshop

    SciTech Connect

    Petrasso, R. D.

    2014-10-01

    A capacity gathering of over 100 researchers from 25 universities and laboratories met at the Laboratory for Laser Energetics (LLE) for the Sixth Omega Laser Facility Users Group (OLUG) workshop. The purpose of the 2.5-day workshop was to facilitate communications and exchanges among individual OMEGA users, and between users and the LLE management; to present ongoing and proposed research; to encourage research opportunities and collaborations that could be undertaken at the Omega Laser Facility and in a complementary fashion at other facilities [such as the National Ignition Facility (NIF) or the Laboratoire pour l’Utilisation des Lasers Intenses (LULI)]; to provide an opportunity for students, postdoctoral fellows, and young researchers to present their research in an informal setting; and to provide feedback from the users to LLE management about ways to improve and keep the facility and future experimental campaigns at the cutting edge.

  14. Water quality management library. 2. edition

    SciTech Connect

    Eckenfelder, W.W.; Malina, J.F.; Patterson, J.W.

    1998-12-31

    A series of ten books offered in conjunction with Water Quality International, the Biennial Conference and Exposition of the International Association on Water Pollution Research and Control (IAWPRC). Volume 1, Activated Sludge Process, Design and Control, 2nd edition, 1998: Volume 2, Upgrading Wastewater Treatment Plants, 2nd edition, 1998: Volume 3, Toxicity Reduction, 2nd edition, 1998: Volume 4, Municipal Sewage Sludge Management, 2nd edition, 1998: Volume 5, Design and Retrofit of Wastewater Treatment Plants for Biological Nutrient Removal, 1st edition, 1992: Volume 6, Dynamics and Control of the Activated Sludge Process, 2nd edition, 1998: Volume 7: Design of Anaerobic Processes for the Treatment of Industrial and Municipal Wastes, 1st edition, 1992: Volume 8, Groundwater Remediation, 1st edition, 1992: Volume 9, Nonpoint Pollution and Urban Stormwater Management, 1st edition, 1995: Volume 10, Wastewater Reclamation and Reuse, 1st edition, 1998.

  15. Site-specific factor involved in the editing of the psbL mRNA in tobacco plastids.

    PubMed Central

    Chaudhuri, S; Carrer, H; Maliga, P

    1995-01-01

    In tobacco plastids, functional psbL mRNA is created by editing an ACG codon to an AUG translation initiation codon. To determine if editing may occur in a chimeric mRNA, the N-terminal part of psbL containing the editing site was translationally fused with the aadA and kan bacterial genes. The chimeric constructs were introduced into the tobacco plastid genome by targeted gene insertion. Editing of the chimeric mRNAs indicated that the 98 nt fragment spanning the psbL editing site contains all cis information required for editing. Expression of the chimeric gene transcripts led to a significant decrease in the editing efficiency of the endogenous psbL mRNA. However, the efficiency of editing in the transplastomic lines was unchanged for four sites in the rpoB and ndhB mRNAs. Reduced efficiency of psbL editing, but not of the other four sites, in the transplastomic lines indicates depletion of psbL-specific editing factor(s). This finding implicates the involvement of site-specific factors in editing of plastid mRNAs in higher plants. Images PMID:7796820

  16. Heat pump manual. Second edition

    SciTech Connect

    Not Available

    1997-11-01

    Since publication of the first edition of the Heat Pump Manual, heat pump technology has evolved and broadened its market appeal, with shipments topping one million units three years in a row. As research reveals new ways to utilize the efficient heat pump cycle, energy efficiency regulations and environmental regulations evolve, and new products enter the market, utilities need to know the basics and keep abreast of the latest. The Heat Pump Manual, Second Edition represents a comprehensive information source on electric heat pump technology, applications, and markets. The first edition of the Heat Pump Manual, published in 1985, set a new standard for technical literature by providing comprehensive information in terms understandable to a broad audience. The expanded second edition brings readers up-to-date with heat pump systems for residential and small commercial buildings and includes 75 new technical illustrations plus tables and charts. 65 figs., 24 tabs.

  17. Modern Physics, 4th edition

    NASA Astrophysics Data System (ADS)

    Tipler, Paul A.; Llewellyn, Ralph

    The new edition of the classic text for the intermediate-level modern physics course, revised and updated to take students to the forefront of contemporary research and applications across the full spectrum of science and technology."

  18. Teaching University Modules in Sixth Forms: The Shifting Boundaries of Post-Compulsory Education?

    ERIC Educational Resources Information Center

    Hall, David; Thomas, Harold

    2004-01-01

    Post-compulsory education in the UK is growing in complexity. A little explored feature of this complexity is the development of collaborative arrangements between higher education institutions and providers of sixth form education under which students can study university modules whilst pursuing their sixth form studies. This article reports the…

  19. View of South TwentySixth Street looking towards Cutting Boulevard at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Sixth Street looking towards Cutting Boulevard at center distance. Sports field on left, Building Nos. 35 & 36 on right and right rear, looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  20. View of intersection of Foothill Avenue and South TwentySixth Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of intersection of Foothill Avenue and South Twenty-Sixth Street. Note sports field at center rear. Seen from Foothill Avenue at Parking Area No. 34, looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  1. View of South TwentySixth Street. Stairs to sports field on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of South Twenty-Sixth Street. Stairs to sports field on right which are seen in photo no. HABS CA-2783-3. Buildings No. 25, 26, 27, seen left to right at rear, looking south - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  2. Favorite Newbery Books of Sixth Grade Students, Teachers, and Library Media Specialists.

    ERIC Educational Resources Information Center

    Kerby, Ramona N.

    1999-01-01

    Identifies Newbery books most frequently chosen as favorites by 2,211 sixth-grade students, sixth-grade teachers, and school library media specialists. FInds that boys chose "Maniac Magee" (Jerry Spinelli), girls chose "Number the Stars" (Lois Lowry), and adults chose "The Giver" (Lois Lowry). (RS)

  3. Fire Safety Power. Sixth Grade. Fire Safety for Texans: Fire and Burn Prevention Curriculum Guide.

    ERIC Educational Resources Information Center

    Texas State Commission on Fire Protection, Austin.

    This booklet comprises the sixth grade component of a series of curriculum guides on fire and burn prevention. Designed to meet the age-specific needs of sixth grade students, its objectives include: (1) developing a comprehensive understanding of fire physics, (2) evaluating electrical hazards and how to respond to those hazards, and (3)…

  4. Connecting Content, Context, and Communication in a Sixth-Grade Social Studies Class through Political Cartoons

    ERIC Educational Resources Information Center

    Gallavan, Nancy P.; Webster-Smith, Angela; Dean, Sheila S.

    2012-01-01

    Sixth-grade students are challenged in understanding social studies content relevant to particular contexts, then connecting the content and context to their contemporary lives while communicating new knowledge to peers and teachers. Using political cartoons published after September 11, 2001, one sixth-grade social studies teacher designed…

  5. Growing Up Strong: A Mental Wellness and Life Skills Development Program for Fifth and Sixth Graders.

    ERIC Educational Resources Information Center

    Hammer, Judith McGowan; O'Bar, Angelina Merenda

    Growing Up Strong (GUS) is a curriculum designed to develop strong mental and physical health in kindergarten through sixth grade students, with the objective of preventing subsequent substance abuse. This document contains a teacher's guide for using GUS in fifth and sixth grade classrooms (GUS 5-6) and duplication masters of materials that can…

  6. Middle-Class Struggle? Identity-Work and Leisure among Sixth Formers in the United Kingdom

    ERIC Educational Resources Information Center

    Kehily, Mary Jane; Pattman, Rob

    2006-01-01

    This paper explores the ways in which sixth-form students in Milton Keynes negotiate their identities and the symbolic significance they attach to leisure activities in the process of doing this. The paper draws upon qualitative, young-person-centred interviews with sixth formers in state and private schools. It addresses the investments of sixth…

  7. Genome edited sheep and cattle.

    PubMed

    Proudfoot, Chris; Carlson, Daniel F; Huddart, Rachel; Long, Charles R; Pryor, Jane H; King, Tim J; Lillico, Simon G; Mileham, Alan J; McLaren, David G; Whitelaw, C Bruce A; Fahrenkrug, Scott C

    2015-02-01

    Genome editing tools enable efficient and accurate genome manipulation. An enhanced ability to modify the genomes of livestock species could be utilized to improve disease resistance, productivity or breeding capability as well as the generation of new biomedical models. To date, with respect to the direct injection of genome editor mRNA into livestock zygotes, this technology has been limited to the generation of pigs with edited genomes. To capture the far-reaching applications of gene-editing, from disease modelling to agricultural improvement, the technology must be easily applied to a number of species using a variety of approaches. In this study, we demonstrate zygote injection of TALEN mRNA can also produce gene-edited cattle and sheep. In both species we have targeted the myostatin (MSTN) gene. In addition, we report a critical innovation for application of gene-editing to the cattle industry whereby gene-edited calves can be produced with specified genetics by ovum pickup, in vitro fertilization and zygote microinjection (OPU-IVF-ZM). This provides a practical alternative to somatic cell nuclear transfer for gene knockout or introgression of desirable alleles into a target breed/genetic line.

  8. Genome editing in cardiovascular diseases.

    PubMed

    Strong, Alanna; Musunuru, Kiran

    2017-01-01

    Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems, have emerged as an invaluable technology to achieve somatic and germline genomic manipulation in cells and model organisms for multiple applications, including the creation of knockout alleles, introducing desired mutations into genomic DNA, and inserting novel transgenes. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this Review, we discuss the applications of genome-editing technology throughout cardiovascular disease research and the prospect of in vivo genome-editing therapies in the future. We also describe some of the existing limitations of genome-editing tools that will need to be addressed if cardiovascular genome editing is to achieve its full scientific and therapeutic potential.

  9. Marine botany. Second edition

    SciTech Connect

    Dawes, C.J.

    1998-12-01

    Marine plants are a diverse group that include unicellular algae, seaweeds, seagrasses, salt marshes, and mangrove forests. They carry out a variety of ecological functions and serve as the primary producers in coastal wetlands and oceanic waters. The theme that connects such a wide variety of plants is their ecology, which was also emphasized in the 1981 edition. The goal of this revision is to present taxonomic, physiological, chemical, and ecological aspects of marine plants, their adaptations, and how abiotic and biotic factors interact in their communities. The data are presented in a concise, comparative manner in order to identify similarities and differences between communities such as salt marsh and mangroves or subtidal seaweeds and seagrasses. To accomplish this, the text is organized into five chapters that introduce the marine habitats, consider abiotic and biotic factors, and anthropogenic influences on the communities followed by seven chapters that deal with microalgae, seaweeds, salt marshes, mangroves, seagrasses, and coral reefs. Two appendixes are included; one presents simple field techniques and the other is a summary of seaweed uses.

  10. Announcement: Release of CDC's 2016 Model Aquatic Health Code, Second Edition and Revised Hyperchlorination and Fecal Incident Response Recommendations.

    PubMed

    2016-07-22

    The 2016 Model Aquatic Health Code (MAHC), Second Edition was released on July 15, 2016 (http://www.cdc.gov/mahc/editions/current.html). MAHC is national guidance that can be voluntarily adopted by state and local jurisdictions to minimize the risk for illness and injury at public aquatic facilities through facility design, construction, operation, maintenance, and management.

  11. Baculovirus-based genome editing in primary cells.

    PubMed

    Mansouri, Maysam; Ehsaei, Zahra; Taylor, Verdon; Berger, Philipp

    2017-01-22

    Genome editing in eukaryotes became easier in the last years with the development of nucleases that induce double strand breaks in DNA at user-defined sites. CRISPR/Cas9-based genome editing is currently one of the most powerful strategies. In the easiest case, a nuclease (e.g. Cas9) and a target defining guide RNA (gRNA) are transferred into a target cell. Non-homologous end joining (NHEJ) repair of the DNA break following Cas9 cleavage can lead to inactivation of the target gene. Specific repair or insertion of DNA with Homology Directed Repair (HDR) needs the simultaneous delivery of a repair template. Recombinant Lentivirus or Adenovirus genomes have enough capacity for a nuclease coding sequence and the gRNA but are usually too small to also carry large targeting constructs. We recently showed that a baculovirus-based multigene expression system (MultiPrime) can be used for genome editing in primary cells since it possesses the necessary capacity to carry the nuclease and gRNA expression constructs and the HDR targeting sequences. Here we present new Acceptor plasmids for MultiPrime that allow simplified cloning of baculoviruses for genome editing and we show their functionality in primary cells with limited life span and induced pluripotent stem cells (iPS).

  12. Biological significance of RNA editing in cells.

    PubMed

    Tang, Wei; Fei, Yongjun; Page, Michael

    2012-09-01

    RNA editing is one of the post-transcriptional RNA processes. RNA editing generates RNA and protein diversity in eukaryotes and results in specific amino acid substitutions, deletions, and changes in gene expression levels. Adenosine-to-inosine RNA editing represents the most important class of editing in human and affects function of many genes. The importance of balancing RNA modification levels across time and space is becoming increasingly evident. In this review, we overview the biological significance of RNA editing including RNA editing in tumorigenesis, RNA editing in neuronal tissues, RNA editing as a regulator of gene expression, and RNA editing in dsRNA-mediated gene silencing, which may increase our understanding of RNA biology.

  13. Talking Food, Doing Gender: The Social Construction of Femininity among Sixth-Grade Girls.

    ERIC Educational Resources Information Center

    Marecek, Jeanne; Arcuri, Lauren

    Two questions serve as the focus in this study on factors affecting perception of femininity among pre-adolescent girls: (1) What are the meanings that girls themselves invested in gender and feminity? and (2) Through what social processes do girls negotiate meanings of gender and femininity? Researchers used a participant-observation study in…

  14. CTD writing and editing standards

    NASA Astrophysics Data System (ADS)

    Caruthers, C. M.

    1991-03-01

    The Computer and Telecommunication Division (CTD) recognizes that the communication of clear, accurate, reasonably complete information is essential to the success of its Laboratory mission. CTD therefore encourages all Division personnel to adhere to the principles of good writing and to the standards for grammar, usage, style, formats, and publication procedures that are described in CTD Writing and Editing Standards. We encourage CTD personnel to read CTD Writing and Editing Standards and to use it continually as a desktop reference. It will help CTD writers to produce better documents consistent with CTD standards in less time. Applying the principles specified in this document on how to write and organize technical information will speed up the editing, review, and revision processes. CTD Writing and Editing Standards complements the Argonne National Laboratory Technical Publications Guide, which serves as the basic Argonne documentation reference on issues concerning DOE orders and guidelines, NRC directives, and other sponsor requirements. However, this Laboratory-wide document does not address matters of grammar or style. Documents recommended in CTD Writing and Editing Standards are usually available for purchase at the Document Distribution Counter (Building 221, Room A-134) or through the mail (by calling extension 2-5405 and ordering copies).

  15. 8 CFR 212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 212.9 Section 212.9 Aliens and... certain derivative third and sixth preference and nonpreference immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who...

  16. 8 CFR 212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 212.9 Section 212.9 Aliens and... certain derivative third and sixth preference and nonpreference immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who...

  17. Proceedings of the sixth annual conference on fossil energy materials

    SciTech Connect

    Cole, N.C.; Judkins, R.R.

    1992-07-01

    The Sixth Annual Conference on Fossil Energy Materials was held in Oak Ridge, Tennessee, on May 12--14, 1992. The meeting was sponsored by the US Department of Energy's Office of Fossil Energy through the Advanced Research and Technology Development (AR TD) Materials Program, and ASM International. The objective of the AR TD Materials Program is to conduct research and development on materials for longer-term fossil energy applications as well as for generic needs of various fossil fuel technologies. The management of the Program has been decentralized to the DOE Field Office, Oak Ridge with Oak Ridge National Laboratory (ORNL) as the technical support contractor. The research is performed by staff members at ORNL and by a substantial number of researchers at other national laboratories, universities, and in private industry. The work is divided into the following categories: (1) ceramics, (2) development and corrosion resistance of iron aluminide, advanced austenitic and chromium-niobium alloys, and (3) technology assessment and technology transfer. This conference is held each year to review the work on all of the projects of the Program. The agenda for the meeting is given in Appendix A, and a list of attendees is presented in Appendix B. ASM International cosponsored the conference, for which we are especially grateful.

  18. Proceedings of the Sixth NASA Langley Formal Methods (LFM) Workshop

    NASA Technical Reports Server (NTRS)

    Rozier, Kristin Yvonne (Editor)

    2008-01-01

    Today's verification techniques are hard-pressed to scale with the ever-increasing complexity of safety critical systems. Within the field of aeronautics alone, we find the need for verification of algorithms for separation assurance, air traffic control, auto-pilot, Unmanned Aerial Vehicles (UAVs), adaptive avionics, automated decision authority, and much more. Recent advances in formal methods have made verifying more of these problems realistic. Thus we need to continually re-assess what we can solve now and identify the next barriers to overcome. Only through an exchange of ideas between theoreticians and practitioners from academia to industry can we extend formal methods for the verification of ever more challenging problem domains. This volume contains the extended abstracts of the talks presented at LFM 2008: The Sixth NASA Langley Formal Methods Workshop held on April 30 - May 2, 2008 in Newport News, Virginia, USA. The topics of interest that were listed in the call for abstracts were: advances in formal verification techniques; formal models of distributed computing; planning and scheduling; automated air traffic management; fault tolerance; hybrid systems/hybrid automata; embedded systems; safety critical applications; safety cases; accident/safety analysis.

  19. The Sixth Alumni Conference of the International Space University

    NASA Technical Reports Server (NTRS)

    Berry, Steve (Editor)

    1997-01-01

    These proceedings cover the sixth alumni conference of the International Space University, coordinated by the ISU U.S. Alumni Organization, which was held at Rice University in Houston, Texas, on July 11, 1997. The alumni conference gives graduates of the International Space University's interdisciplinary, international, and intercultural program a forum in which they may present and exchange technical ideas, and keep abreast of the wide variety of work in which the ever-growing body of alumni is engaged. The diversity that is characteristic of ISU is reflected in the subject matter of the papers published in this proceedings. This proceedings preserves the order of the alumni presentations given at the 1997 ISU Alumni Conference. As in previous years, a special effort was made to solicit papers with a strong connection to the two ISU 1997 Summer Session Program design projects: (1) Transfer of Technology, Spin-Offs, Spin-Ins; and (2) Strategies for the Exploration of Mars. Papers in the remaining ten sessions cover the departmental areas traditional to the ISU summer session program.

  20. Fitness portfolio calibration for first- through sixth-grade children.

    PubMed

    Kulinna, P H; Zhu, W

    2001-12-01

    The purpose of this study was to develop and calibrate health-relatedfitness portfolios for 1st-6th grade students using the many-faceted Rasch model, and examine advantages and disadvantages of a portfolio assessment system based on Rasch calibration. Nine hundred ninety-five studentsfrom 23 schools infirst-sixth grade, who completed three-six of nine health-related fitness portfolios, participated in this study. Ten physical education teachers performed the grading across various portfolios and grade levels. Students'portfolios were rated using 23 predeveloped rubrics, and their scores linked through several common portfolios that were used across schools. The rating scores were analyzed using the many-faceted Rasch model, with four defined facets: portfolio, rubric, student, and rater The model-data fit was very good, and a consistent grade difference wasfound, that is, older students scored higher in fitness knowledge than younger ones. With Rasch calibration, measurement problems in conventional portfolio assessments can be eliminated, and a valid and reliable assessment system can be developed. In addition, several other measurement advantages are provided by Rasch calibration (e.g., related facets can be examined and controlled simultaneously). A large sample size and a more complex process, however, are required in the calibration stage of developing such a system using the Rasch model.

  1. Understanding Editing Behaviors in Multilingual Wikipedia

    PubMed Central

    Hale, Scott A.; Kim, Sooyoung; Byun, Jeongmin; Oh, Alice H.

    2016-01-01

    Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary) languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language. PMID:27171158

  2. Advances in targeted genome editing.

    PubMed

    Perez-Pinera, Pablo; Ousterout, David G; Gersbach, Charles A

    2012-08-01

    New technologies have recently emerged that enable targeted editing of genomes in diverse systems. This includes precise manipulation of gene sequences in their natural chromosomal context and addition of transgenes to specific genomic loci. This progress has been facilitated by advances in engineering targeted nucleases with programmable, site-specific DNA-binding domains, including zinc finger proteins and transcription activator-like effectors (TALEs). Recent improvements have enhanced nuclease performance, accelerated nuclease assembly, and lowered the cost of genome editing. These advances are driving new approaches to many areas of biotechnology, including biopharmaceutical production, agriculture, creation of transgenic organisms and cell lines, and studies of genome structure, regulation, and function. Genome editing is also being investigated in preclinical and clinical gene therapies for many diseases.

  3. Gas Tungsten Arc Welding and Plasma Arc Cutting. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    ERIC Educational Resources Information Center

    Harper, Eddie; Knapp, John

    This packet of instructional materials for a gas tungsten arc welding (GTAW) and plasma arc cutting course is comprised of a teacher edition, student edition, and student workbook. The teacher edition consists of introductory pages and teacher pages. Introductory pages include training and competency profile, state duty/task crosswalk,…

  4. Gas Metal Arc Welding and Flux-Cored Arc Welding. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    ERIC Educational Resources Information Center

    Knapp, John; Harper, Eddie

    This packet, containing a teacher's edition, a student edition, and a student workbook, introduces students to high deposition welding and processes for "shielding" a weld. In addition to general information, the teacher edition consists of introductory pages and teacher pages, as well as unit information that corresponds to the…

  5. CMS Software Notebook. First Edition.

    DTIC Science & Technology

    1979-07-01

    For example, one of my file managing procedures will permit a user to enter the CMS subset to look for a missing file when it is not possible to...Box 17186 Washington, D.C. 20041 CMS userid: ORGASS Please specify if you want the user’s manual or the systems manual. The latter is designed for...8217 CMS SOFTWARE NOTEBOOK*t (First Edition) edited by Richard J. Orgass DT ’ Technical Memorandum No. 79-6 K. July 31, 1979 . ABSTRACT A brief description

  6. Language Editing at Astronomy & Astrophysics

    NASA Astrophysics Data System (ADS)

    Adams, J.

    2011-07-01

    In 2002, the A&A Board of Directors voted that all articles must be written in English and decided to improve the overall quality of the language in the articles with the help of a team of language editors. This article reviews the general advantages of editing the English expression and describes both the aims of this effort and its place in the full publication process. This is followed by the Guide to language editing that has been available on the Journal's website for several years now.

  7. Genome editing comes of age.

    PubMed

    Kim, Jin-Soo

    2016-09-01

    Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field.

  8. Delivery technologies for genome editing.

    PubMed

    Yin, Hao; Kauffman, Kevin J; Anderson, Daniel G

    2017-03-24

    With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems based on CRISPR, as well as transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs), are becoming valuable tools for biomedical research, drug discovery and development, and even gene therapy. However, for each of these systems to effectively enter cells of interest and perform their function, efficient and safe delivery technologies are needed. This Review discusses the principles of biomacromolecule delivery and gene editing, examines recent advances and challenges in non-viral and viral delivery methods, and highlights the status of related clinical trials.

  9. Investigating RNA editing factors from trypanosome mitochondria

    PubMed Central

    Aphasizheva, Inna; Zhang, Liye; Aphasizhev, Ruslan

    2016-01-01

    Mitochondrial U-insertion/deletion mRNA editing is carried out by two principal multiprotein assemblies, enzymatic RNA editing core (RECC) and RNA editing substrate binding (RESC) complexes, and a plethora of auxiliary factors. An integral part of mitochondrial gene expression, editing receives inputs from primary mRNA and gRNA precursor processing pathways, and generates substrates for mRNA polyadenylation and translation. Although nearly all RECC-embedded enzymes have been implicated in specific editing reactions, the majority of proteins that populate the RESC are also essential for generating edited mRNAs. However, lack of recognizable motifs in RESC subunits limits the prowess of bioinformatics in guiding biochemical experiments and elucidating their specific biological functions. In this chapter, we describe a generic workflow for investigating mitochondrial mRNA editing in Trypanosoma brucei and focus on several methods that proved instrumental is assigning definitive functions to editing factors lacking known signature sequences. PMID:27020893

  10. Civil Technology Applications. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Schertz, Karen

    Teacher and student editions of Civil Technology Applications are one in a series of competency-based instructional materials for drafting and civil technology programs. It includes the technical content and tasks necessary for a student to be employed as a drafter or civil technician in a civil engineering firm. Introductory pages in the teacher…

  11. Diesel Technology: Workplace Skills. Teacher Edition and Student Edition.

    ERIC Educational Resources Information Center

    Kellum, Mary

    This publication consists of instructional materials to provide secondary and postsecondary students with skills useful in pursuing a career in the diesel industry. Introductory materials in the teacher edition include information on use of the publication, competency profile, instructional/task analysis, related academic and workplace skills…

  12. Shielded Metal Arc Pipe Welding. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Fortney, Clarence; And Others

    This second edition of the shielded metal arc pipe welding curriculum guide presents both basic and advanced pipe welding skills. All specifications for procedure and welder qualification are presented according to national standards. The standards also include the test position for both groove and fillet pipe welding. The guide contains three…

  13. Power Product Equipment Technician: Equipment Systems. Teacher Edition. Student Edition.

    ERIC Educational Resources Information Center

    Hilley, Robert

    This packet contains teacher and student editions on the topic of equipment systems, intended for the preparation of power product equipment technicians. This publication contains seven units: (1) principles of power transmission; (2) mechanical drive systems; (3) principles of fluid power; (4) hydraulic and pneumatic drive systems; (5) wheel and…

  14. Controlled flexibility in technical editing - The levels-of-edit concept at JPL

    NASA Technical Reports Server (NTRS)

    Buehler, M. F.

    1977-01-01

    The levels-of-edit concept, which can be used to specify the amount of editorial effort involved in the preparation of a manuscript for publication, is discussed. Nine types of editing are identified and described. These include coordination edit (preparing estimates, gathering cost data, monitoring production processes), policy edit, integrity edit (making sure that parts of a publication match in a physical or numerical sense), screening edit (ensuring that the quality of camera-ready copy is sufficient for external publication), copy clarification edit, format edit, mechanical style edit, language edit, and substantive edit (reviewing the manuscript for content coherence, emphasis, subordination and parallelism). These functions are grouped into five levels of edit. An edit-level number is assigned to each manuscript, providing a quantitative and qualitative indicator of the editing to be done which is clearly understood by authors, managers, and editors alike. In addition, clear boundaries are drawn between normal and extraordinary editing tasks. Individual organizations will group various edits in different ways to reflect their needs and priorities; the essential element of the system is unambiguous definition and coding of the types and amount of work to be done.

  15. Human Genome Editing and Ethical Considerations.

    PubMed

    Krishan, Kewal; Kanchan, Tanuj; Singh, Bahadur

    2016-04-01

    Editing human germline genes may act as boon in some genetic and other disorders. Recent editing of the genome of the human embryo with the CRISPR/Cas9 editing tool generated a debate amongst top scientists of the world for the ethical considerations regarding its effect on the future generations. It needs to be seen as to what transformation human gene editing brings to humankind in the times to come.

  16. 48 CFR 53.102 - Current editions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Current editions. 53.102... AND FORMS FORMS General 53.102 Current editions. The form prescriptions in subpart 53.2 and the illustrations in subpart 53.3 contain current edition dates. Contracting officers shall use the current...

  17. Strategies of Qualitative Inquiry. Third Edition

    ERIC Educational Resources Information Center

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    2007-01-01

    "Strategies of Qualitative Inquiry, Third Edition," the second volume in the paperback version of "The SAGE Handbook of Qualitative Research, 3rd Edition," consists of Part III of the handbook ("Strategies of Inquiry"). "Strategies of Qualitative Inquiry, Third Edition" presents the major tactics--historically, the research methods--that…

  18. American Reference Books Annual 1974. Fifth Edition.

    ERIC Educational Resources Information Center

    Wynar, Bohdan S., Ed.; And Others

    The fifth edition of American Reference Books Annual (ARBA 74) provides a comprehensive listing of reference books published or distributed in the United States with 1973 imprints, plus those published too late in 1972 to be included in the fourth edition. Like other editions of ARBA, ARBA 74 reviews library science publications, reprints, and…

  19. Sixth International Conference on Squeezed States and Uncertainty Relations

    NASA Technical Reports Server (NTRS)

    Han, D. (Editor); Kim, Y. S. (Editor); Solimento, S. (Editor)

    2000-01-01

    These proceedings contain contributions from about 200 participants to the 6th International Conference on Squeezed States and Uncertainty Relations (ICSSUR'99) held in Naples May 24-29, 1999, and organized jointly by the University of Naples "Federico II," the University of Maryland at College Park, and the Lebedev Institute, Moscow. This was the sixth of a series of very successful meetings started in 1990 at the College Park Campus of the University of Maryland. The other meetings in the series were held in Moscow (1992), Baltimore (1993), Taiyuan P.R.C. (1995) and Balatonfuered, Hungary (1997). The present one was held at the campus Monte Sant'Angelo of the University "Federico II" of Naples. The meeting sought to provide a forum for updating and reviewing a wide range of quantum optics disciplines, including device developments and applications, and related areas of quantum measurements and quantum noise. Over the years, the ICSSUR Conference evolved from a meeting on quantum measurement sector of quantum optics, to a wide range of quantum optics themes, including multifacet aspects of generation, measurement, and applications of nonclassical light (squeezed and Schrodinger cat radiation fields, etc.), and encompassing several related areas, ranging from quantum measurement to quantum noise. ICSSUR'99 brought together about 250 people active in the field of quantum optics, with special emphasis on nonclassical light sources and related areas. The Conference was organized in 8 Sections: Squeezed states and uncertainty relations; Harmonic oscillators and squeeze transformations; Methods of quantum interference and correlations; Quantum measurements; Generation and characterisation of non-classical light; Quantum noise; Quantum communication and information; and Quantum-like systems.

  20. Force fields, floating frogs and levitating trains: a sixth-form project in computational physics

    NASA Astrophysics Data System (ADS)

    Phillips, C. J.; Evans, S.; Roy, W.; Chantrell, M.; Bradbury, A.; Llewellyn, P.; Chantrell, R. W.

    1999-07-01

    A short course for sixth-form students introducing the concept of computational physics is described. The course was found to be effective in introducing computational physics as a discipline and in highlighting some important mathematical and physical concepts.

  1. Relationship of Trait Anxiety, Peer Presence, Task Difficulty, and Skill Acquisition of Sixth-Grade Boys

    ERIC Educational Resources Information Center

    Kieffer, Leigh F.

    1977-01-01

    The effect of audience and task difficulty on the learning and performance of forty, high-anxious, sixth-grade students was examined, with data favoring the hypothesis that a spectator reduces drive and reassures the learner. (MJB)

  2. A Social-Cognitive Developmental Intervention with Sixth and First Graders

    ERIC Educational Resources Information Center

    Enright, Robert D.; And Others

    1977-01-01

    This paper focuses on a cross-age intervention program in which sixth graders led discussion groups with first graders using Selman's (1974) levels of interpersonal conceptions as the content area. Presented at the American Psychological Association, Chicago, 1975. (Author)

  3. 78 FR 61445 - Seventy-Sixth Meeting: RTCA Special Committee 147, Minimum Operational Performance Standards for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... Performance Standards for Traffic Alert and Collision Avoidance Systems Airborne Equipment AGENCY: Federal... Special Committee 147, Minimum Operational Performance Standards for Traffic Alert and Collision Avoidance...-Sixth meeting of RTCA Special Committee 147, Minimum Operational Performance Standards for Traffic...

  4. 78 FR 66419 - Seventy Sixth Meeting: RTCA Special Committee 147, Minimum Operational Performance Standards for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... Performance Standards for Traffic Alert and Collision Avoidance Systems Airborne Equipment AGENCY: Federal... Special Committee 147, Minimum Operational Performance Standards for Traffic Alert and Collision Avoidance... Sixth meeting of RTCA Special Committee 147, Minimum Operational Performance Standards for Traffic...

  5. Teaching Population Concepts. Revised Edition.

    ERIC Educational Resources Information Center

    King, Pat; Landahl, John

    This edition is designed to help teachers provide their students with some basic population concepts with stress placed on the elements of decision making. In the first section of the pamphlet, some of the basic concepts of population study are presented. These include populations, growth rates, birth and death rates, doubling time, migration, age…

  6. Nuclear Electricity. 5th Edition.

    ERIC Educational Resources Information Center

    Hore-Lacy, Ian

    Educators must address the need for young people to be informed about both the scientific concepts and the reasons for controversy when dealing with controversial issues. Young people must be given the opportunity to form their own opinions when presented with evidence for conflicting arguments. Previous editions of "Nuclear Electricity" have…

  7. The Horizon Report. 2006 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2006

    2006-01-01

    This third edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing discussions…

  8. Veterinary Microbiology, 3rd Edition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  9. The Horizon Report. 2005 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2005

    2005-01-01

    This second edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series…

  10. The Horizon Report. 2007 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2007

    2007-01-01

    This fourth edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing…

  11. Modern Indian Psychology. Revised Edition.

    ERIC Educational Resources Information Center

    Bryde, John F.

    Written on the basis of senior Indian verbal relatings collected over a 23-year span, this revised edition on modern Indian psychology incorporates suggestions from Indian students and their teachers, Indian and non-Indian social studies experts, and other Indian people. The book contains 6 major divisions: (1) "Culture and Indian…

  12. Resident Care Guide. Third Edition.

    ERIC Educational Resources Information Center

    Woodbridge State School, NJ.

    The third edition of the Woodbridge State School Cottage Life Department Resident Care Guide is explained to be a developmental status scale devised in 1969 as part of a 5-year study for the purposes of measuring the entire population's self-help training abilities. The department is said to serve 954 residents; 424 are non-ambulatory and 530 are…

  13. Direct Instruction Reading. Third Edition.

    ERIC Educational Resources Information Center

    Carnine, Douglas W.; And Others

    Creating a learning and instructional environment for teaching students in a "humane and efficient" manner, this book is designed to empower teachers by providing them with specific suggestions for problems they will encounter as they provide students with direct, explicit instruction in reading. As in earlier editions, the book devotes…

  14. How Adults Learn. Revised Edition.

    ERIC Educational Resources Information Center

    Kidd, J. R.

    The book's emphasis is on learning during the years of adulthood and examines present-day practice of adult education for practitioners. This revised edition brings up to date advances in such areas of learning as controversial theory; the effects of environment; sensory processes; intellectual capacities; motivation and attitude; transactional…

  15. Unlocking Mathematics Teaching. Second Edition

    ERIC Educational Resources Information Center

    Koshy, Valsa, Ed.; Murray, Jean, Ed.

    2011-01-01

    Now in a fully updated second edition, "Unlocking Mathematics Teaching" is a comprehensive guide to teaching mathematics in the primary school. Combining theory and practice, selected experts outline the current context of mathematics education. They suggest strategies, activities and examples to help develop readers understanding and confidence…

  16. Money and Schools. Fifth Edition

    ERIC Educational Resources Information Center

    Thompson, David C.; Crampton, Faith E.; Wood, R. Craig

    2012-01-01

    In the new edition of this essential, all-inclusive text, the authors provide more important research for future principals and others enrolled in graduate-level school finance courses. Written in a style that is highly readable, the book offers strong connections to real-world experiences. Readers get both a broad overview of funding concepts and…

  17. The Horizon Report. 2004 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2004

    2004-01-01

    This first edition of the New Media Consortium's (NMC) annual "Horizon Report" details findings of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series of interviews…

  18. Strengthening Family Resilience, Second Edition

    ERIC Educational Resources Information Center

    Walsh, Froma

    2006-01-01

    In a fully revised, updated, and expanded second edition, this informative clinical resource and text presents Froma Walsh's family resilience framework for intervention and prevention with clients dealing with adversity. Drawing on extensive research and clinical experience, the author describes key processes in resilience for practitioners to…

  19. Teaching Reading Sourcebook, Second Edition

    ERIC Educational Resources Information Center

    Honig, Bill; Diamond, Linda; Gutlohn, Linda

    2008-01-01

    The "Teaching Reading Sourcebook, Second Edition" is a comprehensive reference about reading instruction. Organized according to the elements of explicit instruction (what? why? when? and how?), the "Sourcebook" includes both a research-informed knowledge base and practical sample lesson models. It teaches the key elements of an effective reading…

  20. Fluency: Strategies & Assessments. Third Edition

    ERIC Educational Resources Information Center

    Johns, Jerry L.; Berglund, Roberta L.

    2006-01-01

    This book presents numerous practical strategies and assessment tools teachers can use immediately to strengthen students' fluency skills in regular classrooms and in resource rooms. This new third edition offers: (1) Concise answers to teachers' questions; (2) Evidence-based strategies; (3) Practical activities; (4) Resources to develop students'…

  1. Toxic Substances List. 1972 Edition.

    ERIC Educational Resources Information Center

    Christensen, Herbert E., Ed.; And Others

    The second edition of the Toxic Substances List, containing some 13,000 entries, is prepared annually by the National Institute for Occupational Safety and Health (NIOSH) in compliance with the Occupational Safety and Health Act of 1970. The purpose of the List is to identify all known toxic substances but not to quantitate the hazard. The List…

  2. Isolated sixth cranial nerve aplasia visualized with Fast Imaging Employing Steady-State Acquisition (FIESTA) MRI.

    PubMed

    Pilyugina, Svetlana A; Fischbein, Nancy J; Liao, Y Joyce; McCulley, Timothy J

    2007-06-01

    An otherwise healthy 12-month-old girl presented for evaluation of reduced abduction of the left eye detected at 6 months of age. The remainder of the examination was unremarkable. A special MRI sequence-fast imaging employing steady-state acquisition (FIESTA)-visualized the right but not the left sixth nerve cisternal segment. This is the first reported use of the MRI FIESTA sequence to diagnose aplasia of the sixth cranial nerve.

  3. Summaries of the Sixth Annual JPL Airborne Earth Science Workshop. Volume 2; AIRSAR Workshop

    NASA Technical Reports Server (NTRS)

    Kim, Yun-Jin (Editor)

    1996-01-01

    The Sixth Annual JPL Airborne Earth Science Workshop, held in Pasadena, California, on March 4-8, 1996, was divided into two smaller workshops:(1) The Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) workshop, and The Airborne Synthetic Aperture Radar (AIRSAR) workshop. This current paper, Volume 2 of the Summaries of the Sixth Annual JPL Airborne Earth Science Workshop, presents the summaries for The Airborne Synthetic Aperture Radar (AIRSAR) workshop.

  4. Summary of the Sixth Persh Workshop: Corrosion Policy Guiding Science and Technology

    DTIC Science & Technology

    2016-01-01

    CPO and chartered with a directive to find “out of the box” research directions . The primary focus of this published study was to address how science ...ARL-TR-7571 ● JAN 2016 US Army Research Laboratory Summary of the Sixth Persh Workshop: Corrosion Policy Guiding Science and...Sixth Persh Workshop: Corrosion Policy Guiding Science and Technology by Pauline M Smith Weapons and Materials Research Directorate, ARL

  5. Basics and applications of genome editing technology.

    PubMed

    Yamamoto, Takashi; Sakamoto, Naoaki

    Genome editing with programmable site-specific nucleases is an emerging technology that enables the manipulation of targeted genes in many organisms and cell lines. Since the development of the CRISPR-Cas9 system in 2012, genome editing has rapidly become an indispensable technology for all life science researchers, applicable in various fields. In this seminar, we will introduce the basics of genome editing and focus on the recent development of genome editing tools and technologies for the modification of various organisms and discuss future directions of the genome editing research field, from basic to medical applications.

  6. Diesel Technology: Steering and Suspension. Second Edition. Teacher Edition [and] Student Edition.

    ERIC Educational Resources Information Center

    Miller, Roger; Scarberry, Terry; Tesch, Carl; Kellum, Mary

    These teacher and student editions on steering and suspension are part of the diesel mechanics series of instructional materials. The series aligns with the medium/heavy duty truck task list developed by the National Automotive Technicians Education Foundation and used by the National Institute for Automotive Service Excellence in the…

  7. Diesel Technology: Safety Skills. Teacher Edition [and] Student Edition. Second Edition.

    ERIC Educational Resources Information Center

    Kellum, Mary

    Teacher and student editions of this document are one in a series of competency-based instructional materials for diesel technology programs. The series aligns with the medium/heavy diesel duty truck task list used by the National Institute for Automotive Service Excellence in the certification of medium/heavy duty truck technicians. Introductory…

  8. PREFACE: The Sixth International Conference on Gravitation & Cosmology

    NASA Astrophysics Data System (ADS)

    Date, Ghanashyam; Souradeep, Tarun

    2008-07-01

    The sixth International Conference on Gravitation & Cosmology (ICGC-2007) was organized at IUCAA, Pune, 17-21 December 2007. This series of international meetings, held every four years under the auspices of the Indian Association for General Relativity and Gravitation (IAGRG), has now spanned two decades. Previous ICGC meetings were held at Cochin University of Science and Technology (2004), Indian Institute of Technology, Kharagpur (2000), IUCAA, Pune (1995), Physical Research Laboratory, Ahmedabad (1991) & Goa (1987). These meetings have broad international participation and feature leading experts in the field of Cosmology, gravitational waves and quantum gravity. The frontier of research in Gravitation and Cosmology has seen remarkable progress in the past decades. On the theoretical front, black holes and cosmological singularities continue to challenge and attract quantum gravity researchers. The quest for the detection of Gravitational waves and the promise of gravitational wave astronomy continues to grow and breakthroughs of the past couple of years indicate that numerical relativity is catching up too. The past few years have also seen very ambitious experimental efforts to verify general relativity as the theory of gravitation. Cosmology has been veritably transformed into a precision science with the tremendous improvement in the quantity and quality of cosmological observations. The exquisite measurements not only allow refinement of the cosmological model parameters but have begun to allow observational tests of underlying fundamental assumptions and hunt for subtle deviations that could be the key to understanding the early universe. The sixth meeting brought together active scientists from all over the globe to present the state of the art at the frontiers of research. It also offered younger Indian researchers an opportunity for interaction with experts from within India and abroad. The meeting was attended by over 160 participants. The scientific

  9. Deciphering the functions and regulation of brain-enriched A-to-I RNA editing.

    PubMed

    Li, Jin Billy; Church, George M

    2013-11-01

    Adenosine-to-inosine (A-to-I) RNA editing, in which genomically encoded adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on RNA (ADAR). This fine-tuning mechanism is critical during normal development and diseases, particularly in relation to brain functions. A-to-I RNA editing has also been hypothesized to be a driving force in human brain evolution. A large number of RNA editing sites have recently been identified, mostly as a result of the development of deep sequencing and bioinformatic analyses. Deciphering the functional consequences of RNA editing events is challenging, but emerging genome engineering approaches may expedite new discoveries. To understand how RNA editing is dynamically regulated, it is imperative to construct a spatiotemporal atlas at the species, tissue and cell levels. Future studies will need to identify the cis and trans regulatory factors that drive the selectivity and frequency of RNA editing. We anticipate that recent technological advancements will aid researchers in acquiring a much deeper understanding of the functions and regulation of RNA editing.

  10. An automated system for terrain database construction

    NASA Technical Reports Server (NTRS)

    Johnson, L. F.; Fretz, R. K.; Logan, T. L.; Bryant, N. A.

    1987-01-01

    An automated Terrain Database Preparation System (TDPS) for the construction and editing of terrain databases used in computerized wargaming simulation exercises has been developed. The TDPS system operates under the TAE executive, and it integrates VICAR/IBIS image processing and Geographic Information System software with CAD/CAM data capture and editing capabilities. The terrain database includes such features as roads, rivers, vegetation, and terrain roughness.

  11. Selection of highly efficient sgRNAs for CRISPR/Cas9-based plant genome editing.

    PubMed

    Liang, Gang; Zhang, Huimin; Lou, Dengji; Yu, Diqiu

    2016-02-19

    The CRISPR/Cas9-sgRNA system has been developed to mediate genome editing and become a powerful tool for biological research. Employing the CRISPR/Cas9-sgRNA system for genome editing and manipulation has accelerated research and expanded researchers' ability to generate genetic models. However, the method evaluating the efficiency of sgRNAs is lacking in plants. Based on the nucleotide compositions and secondary structures of sgRNAs which have been experimentally validated in plants, we instituted criteria to design efficient sgRNAs. To facilitate the assembly of multiple sgRNA cassettes, we also developed a new strategy to rapidly construct CRISPR/Cas9-sgRNA system for multiplex editing in plants. In theory, up to ten single guide RNA (sgRNA) cassettes can be simultaneously assembled into the final binary vectors. As a proof of concept, 21 sgRNAs complying with the criteria were designed and the corresponding Cas9/sgRNAs expression vectors were constructed. Sequencing analysis of transgenic rice plants suggested that 82% of the desired target sites were edited with deletion, insertion, substitution, and inversion, displaying high editing efficiency. This work provides a convenient approach to select efficient sgRNAs for target editing.

  12. [Application Progress of CRISPR/Cas9 System for Gene Editing in Tumor Research].

    PubMed

    Liu, Chao; Li, Zhiwei; Zhang, Yanqiao

    2015-09-20

    TCRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-associated nuclease 9) gene editing system is a new type of gene editing technology developed based on the immune mechanism of archaea resisting the invasion of exogenous nucleic acid. Compared with traditional gene editing system, CRISPR/Cas9 system is more efficient, easier operating, and less cytotoxic. Currently, CRISPR/Cas9 gene editing technology has been applied to many aspects of cancer research, including research on cancer genes, constructing animal tumor models, screening tumor resistance-associated and phenotypic-related genes and cancer gene therapy. In this review, the application of the CRISPR/Cas9 system in tumor research were introduced.

  13. EDITORIAL: Sixth World Congress on Industrial Process Tomography (WCIPT6) Sixth World Congress on Industrial Process Tomography (WCIPT6)

    NASA Astrophysics Data System (ADS)

    Takei, Masahiro; Xu, Lijun

    2011-10-01

    We are pleased to publish this special feature on the Sixth World Congress on Industrial Process Tomography (WCIPT6) in Measurement Science and Technology. The international congress was successfully held in the campus of Beihang University, Beijing, China, from 6-9 September 2010. It was jointly organized by International Society for Industrial Process Tomography (ISIPT), North China Electric Power University (NCEPU) and Beihang University (BUAA). Process tomography is a tangible tool to visualize and determine the material distribution inside a process non-intrusively in real time. The internal features that can be monitored by process tomography are frequently encountered and required in the design of processes and industrial plants in the fields of chemical, oil, power and metallurgical engineering as well as many other activities such as food, material handling and combustion systems. One of the key characteristics of process tomography is to provide a direct impression and instant and clear understanding of a complex phenomenon. From the viewpoint of practical applications, industries all over the world are currently facing a number of daunting challenges including many wide-range and complex technical problems. The innovative technology of process tomography consistently contributes to providing better and better solutions to the problems as 'seeing is believing'. As a regular event, WCIPT is playing a more and more important role in addressing the challenges to overcome these problems. We are glad to see that this special feature provides a great opportunity for world-wide top-level researchers to discuss and make further developments in process tomography and its applications. The 20 articles included in this issue cover a wide range of relevant topics including sensors and sensing mechanisms, data acquisition systems and instrumentation, electrical, optical, acoustic and hybrid systems, image reconstruction and system evaluation, data and sensor fusion

  14. Sedimentary petrology. 2nd edition

    SciTech Connect

    Blatt, H.

    1992-01-01

    The second edition of Sedimentary Petrology is extensively revised and updated; much effort has been expended to strengthen the weaknesses of the earlier edition, and much of this effort has been successful. It consists of sixteen chapters. Following two introductory chapters (occurrence of sedimentary rocks; weathering and soils), eleven chapters cover the various sedimentary rock types. Coverage is allocated in proportion to their relative abundance and relative ease of study -- three chapters on conglomerates and sandstones (textures and structures, composition, and diagenesis); one on mud rocks; three on carbonates (limestone textures, structures, and environments; limestone mineralogy and diagenesis; and dolostones); and one each on evaporites, cherts, iron-rich rocks, and phosphorites. A novel and useful chapter on paleogeothermometry rounds out the discussion of rocks, followed by chapters on The Development of a Research Project'' and common laboratory methods.

  15. Strategic Leadership Primer (Third Edition)

    DTIC Science & Technology

    2010-01-01

    Meinhart, while also acknowledging previous edition contributions from Dr� Lenny Wong, Dr� Craig Bullis , and Colonel (Ret) George Reed� 1 CHAPTER 1...the cyber war� Although the strategies are different between commercial and government entities, at the end of the day both seek competitive...and everyone else—to 140 characters per tweet, and he tweets once or more almost daily�4 400 million people have established accounts on Facebook �5

  16. Electromagnetic Fields, 2nd Edition

    NASA Astrophysics Data System (ADS)

    Wangsness, Roald K.

    1986-07-01

    This revised edition provides patient guidance in its clear and organized presentation of problems. It is rich in variety, large in number and provides very careful treatment of relativity. One outstanding feature is the inclusion of simple, standard examples demonstrated in different methods that will allow students to enhance and understand their calculating abilities. There are over 145 worked examples; virtually all of the standard problems are included.

  17. The evolution of chloroplast RNA editing.

    PubMed

    Tillich, Michael; Lehwark, Pascal; Morton, Brian R; Maier, Uwe G

    2006-10-01

    RNA editing alters the nucleotide sequence of an RNA molecule so that it deviates from the sequence of its DNA template. Different RNA-editing systems are found in the major eukaryotic lineages, and these systems are thought to have evolved independently. In this study, we provide a detailed analysis of data on C-to-U editing sites in land plant chloroplasts and propose a model for the evolution of RNA editing in land plants. First, our data suggest that the limited RNA-editing system of seed plants and the much more extensive systems found in hornworts and ferns are of monophyletic origin. Further, although some eukaryotic editing systems appear to have evolved to regulate gene expression, or at least are now involved in gene regulation, there is no evidence that RNA editing plays a role in gene regulation in land plant chloroplasts. Instead, our results suggest that land plant chloroplast C-to-U RNA editing originated as a mechanism to generate variation at the RNA level, which could complement variation at the DNA level. Under this model, many of the original sites, particularly in seed plants, have been subsequently lost due to mutation at the DNA level, and the function of extant sites is merely to conserve certain codons. This is the first comprehensive model for the evolution of the chloroplast RNA-editing system of land plants and may also be applicable to the evolution of RNA editing in plant mitochondria.

  18. RNA editing in plant mitochondria.

    PubMed

    Hiesel, R; Wissinger, B; Schuster, W; Brennicke, A

    1989-12-22

    Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.

  19. Editing as a psychological practice.

    PubMed

    Beebe, John

    2006-06-01

    The experience of the Jungian analyst in the role of editor of manuscripts by creative colleagues is examined. Historical precedents include Michael Fordham's editorial correspondence with Jung around the latter's synchronicity essay; Jung's handling of manuscripts submitted by Sabina Spielrein to the Jahrbuch für psychoanalytische und psychopathologische Forschungen and various authors to the Zentralblatt für Psychotherapie und ihre Grenzgebiete, and the author's close editing of a paper submitted by Andrew Samuels to the Journal of Analytical Psychology. In addition to mustering an adequate amount of generosity, erudition, and availability, the analytic editor must know how to clarify a psychological argument and to gauge the psychological impact of the written text. Notwithstanding transference/countertransference phenomena that can emerge around issues of competition, envy, and territoriality when author and editor are also fellow-authors working in the same field, the editor needs to be comfortable about serving as the author's selfobject and midwife. From an analytic perspective, although communicating decisions about the best way to put ideas into words can sometimes attract transference to the editor, the more profound transference that analysts experience in the editing situation is toward the text being edited, which helps to motivate donated time spent caring for journal manuscripts.

  20. RNA Editing in Plant Mitochondria

    NASA Astrophysics Data System (ADS)

    Hiesel, Rudolf; Wissinger, Bernd; Schuster, Wolfgang; Brennicke, Axel

    1989-12-01

    Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.

  1. Learning to write in science: A study of English language learners' writing experience in sixth-grade science classrooms

    NASA Astrophysics Data System (ADS)

    Qi, Yang

    Writing is a predictor of academic achievement and is essential for student success in content area learning. Despite its importance, many students, including English language learners (ELLs), struggle with writing. There is thus a need to study students' writing experience in content area classrooms. Informed by systemic functional linguistics, this study examined 11 ELL students' writing experience in two sixth grade science classrooms in a southeastern state of the United States, including what they wrote, how they wrote, and why they wrote in the way they did. The written products produced by these students over one semester were collected. Also collected were teacher interviews, field notes from classroom observations, and classroom artifacts. Student writing samples were first categorized into extended and nonextended writing categories, and each extended essay was then analyzed with respect to its schematic structure and grammatical features. Teacher interviews and classroom observation notes were analyzed thematically to identify teacher expectations, beliefs, and practices regarding writing instruction for ELLs. It was found that the sixth-grade ELLs engaged in mostly non-extended writing in the science classroom, with extended writing (defined as writing a paragraph or longer) constituting roughly 11% of all writing assignments. Linguistic analysis of extended writing shows that the students (a) conveyed information through nouns, verbs, adjectives, adverbial groups and prepositional phrases; (b) constructed interpersonal context through choices of mood, modality, and verb tense; and (c) structured text through thematic choices and conjunctions. The appropriateness of these lexicogrammatical choices for particular writing tasks was related to the students' English language proficiency levels. The linguistic analysis also uncovered several grammatical problems in the students' writing, including a limited range of word choices, inappropriate use of mood

  2. REQUIREMENTS FOR HAZARDOUS WASTE LANDFILL DESIGN, CONSTRUCTION AND CLOSURE

    EPA Science Inventory

    This publication contains edited versions of the material presented at ten Technology Transfer seminars conducted in 1988 on this subject. Sections are included on design of clay and flexible membrane liners, leachate collector systems, and landfill covers. Construction quality a...

  3. An agent based model of genotype editing

    SciTech Connect

    Rocha, L. M.; Huang, C. F.

    2004-01-01

    This paper presents our investigation on an agent-based model of Genotype Editing. This model is based on several characteristics that are gleaned from the RNA editing system as observed in several organisms. The incorporation of editing mechanisms in an evolutionary agent-based model provides a means for evolving agents with heterogenous post-transcriptional processes. The study of this agent-based genotype-editing model has shed some light into the evolutionary implications of RNA editing as well as established an advantageous evolutionary computation algorithm for machine learning. We expect that our proposed model may both facilitate determining the evolutionary role of RNA editing in biology, and advance the current state of research in agent-based optimization.

  4. Two DYW subclass PPR proteins are involved in RNA editing of ccmFc and atp9 transcripts in the moss Physcomitrella patens: first complete set of PPR editing factors in plant mitochondria.

    PubMed

    Ichinose, Mizuho; Sugita, Chieko; Yagi, Yusuke; Nakamura, Takahiro; Sugita, Mamoru

    2013-11-01

    The moss Physcomitrella patens has 11 RNA editing sites in mitochondrial transcripts. We previously identified six DYW subclass pentatricopeptide repeat (PPR) proteins as RNA editing factors for nine out of 11 sites. In this study, we identified two novel DYW subclass PPR proteins, PpPPR_65 and PpPPR_98, as RNA editing factors. Disruption of the PpPPR_65 gene resulted in a complete loss of RNA editing at two neighboring sites, ccmFc-C103 and ccmFc-C122, in the mitochondrial ccmFc transcript. To confirm this result, we further generated PpPPR_65 knockdown (KD) mutants by an inducible RNA interference (RNAi) system. The generated RNAi lines displayed reduced levels of RNA editing at both ccmFc-C103 and ccmFc-C122 sites. Next, we characterized the function of PpPPR_98 by constructing a KD mutant of PpPPR_98 expression. The KD mutant showed a 30% reduction in the level of atp9-C92 editing. When PpPPR_98 cDNA was introduced into the KD mutant, RNA editing levels were restored to the wild-type level. This indicates that PpPPR_98 is an editing factor for the atp9-C92 site. The recombinant PpPPR_98 protein bound to the upstream sequence of the editing site that was created by splicing of atp9 transcript. This suggests that atp9 RNA editing occurs after splicing of atp9 transcript. Our present and previous data provide the first evidence that all 11 known editing events require at least eight DYW subclass PPR proteins in the moss mitochondria.

  5. Introduction to Insulation. Introduction to Construction Series. Instructor Edition.

    ERIC Educational Resources Information Center

    Associated General Contractors of America, Washington, DC.

    This module on introductory insulation is one of a series of modules designed to teach basic skills necessary for entry-level employment in this field. The instructor's guide contains three instructional units that cover the following topics: (1) insulation materials; (2) insulation tools; and (3) insulation layout and basic skills. Each…

  6. A Model Framework for Course Materials Construction (Second Edition).

    ERIC Educational Resources Information Center

    Schlenker, Richard M.

    Designed for use by Coast Guard course writers, curriculum developers, course coordinators, and instructors as a decision-support system, this publication presents a model that translates the Intraservices Procedures for Instructional Systems Development curriculum design model into materials usable by classroom teachers and students. Although…

  7. Image Editing Via Searching Source Image

    NASA Astrophysics Data System (ADS)

    Yu, Han; Deng, Liang-Jian

    Image editing has important applications by changing the image texture, illumination, target location, etc. As an important application of Poisson equation, Poisson image editing processes images on the gradient domain and has been applied to seamless clone, selection editing, image denoising, etc. In this paper, we present a new application of Poisson image editing, which is based on searching source image. The main feature of the new application is all modifying information comes from the source image. Experimental results show that the proposed application performs well.

  8. Editing in Technical Communication: Theory and Practice in Editing Processes at the Graduate Level.

    ERIC Educational Resources Information Center

    Masse, Roger E.

    At New Mexico State University, technical communication teachers have developed a course to teach editing processes to graduate students who take the advanced workshop in technical and professional communication. In this seminar group, students work on writing processes; editing processes; written, edited, and tested products; and oral processes…

  9. Environmental Studies. The Construction of an 'A' Level Syllabus.

    ERIC Educational Resources Information Center

    Carson, S. McB.

    In response to the increasing social concern for the quality of the environment and its conservation, and the need to ensure that all pupils in their final years of schooling be brought to share that concern, teachers in Hertfordshire, England, have constructed an 'A' level curriculum or syllabus of environmental studies for the sixth form. Based…

  10. Single-edition quadrangle maps

    USGS Publications Warehouse

    ,

    1998-01-01

    In August 1993, the U.S. Geological Survey's (USGS) National Mapping Division and the U.S. Department of Agriculture's Forest Service signed an Interagency Agreement to begin a single-edition joint mapping program. This agreement established the coordination for producing and maintaining single-edition primary series topographic maps for quadrangles containing National Forest System lands. The joint mapping program saves money by eliminating duplication of effort by the agencies and results in a more frequent revision cycle for quadrangles containing national forests. Maps are revised on the basis of jointly developed standards and contain normal features mapped by the USGS, as well as additional features required for efficient management of National Forest System lands. Single-edition maps look slightly different but meet the content, accuracy, and quality criteria of other USGS products. The Forest Service is responsible for the land management of more than 191 million acres of land throughout the continental United States, Alaska, and Puerto Rico, including 155 national forests and 20 national grasslands. These areas make up the National Forest System lands and comprise more than 10,600 of the 56,000 primary series 7.5-minute quadrangle maps (15-minute in Alaska) covering the United States. The Forest Service has assumed responsibility for maintaining these maps, and the USGS remains responsible for printing and distributing them. Before the agreement, both agencies published similar maps of the same areas. The maps were used for different purposes, but had comparable types of features that were revised at different times. Now, the two products have been combined into one so that the revision cycle is stabilized and only one agency revises the maps, thus increasing the number of current maps available for National Forest System lands. This agreement has improved service to the public by requiring that the agencies share the same maps and that the maps meet a

  11. Fuel Cell Handbook, Fourth Edition

    SciTech Connect

    Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

    1998-11-01

    Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

  12. NASA Pocket Statistics: 1997 Edition

    NASA Technical Reports Server (NTRS)

    1997-01-01

    POCKET STATISTICS is published by the NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (NASA). Included in each edition is Administrative and Organizational information, summaries of Space Flight Activity including the NASA Major Launch Record, Aeronautics and Space Transportation and NASA Procurement, Financial and Workforce data. The NASA Major Launch Record includes all launches of Scout class and larger vehicles. Vehicle and spacecraft development flights are also included in the Major Launch Record. Shuttle missions are counted as one launch and one payload, where free flying payloads are not involved. All Satellites deployed from the cargo bay of the Shuttle and placed in a separate orbit or trajectory are counted as an additional payload.

  13. Biocommunication and natural genome editing

    PubMed Central

    Witzany, Guenther

    2010-01-01

    The biocommunicative approach investigates communication processes within and among cells, tissues, organs and organisms as sign-mediated interactions, and nucleotide sequences as code, i.e. language-like text, which follows in parallel three kinds of rules: combinatorial (syntactic), context-sensitive (pragmatic), and content-specific (semantic). Natural genome editing from a biocommunicative perspective is competent agent-driven generation and integration of meaningful nucleotide sequences into pre-existing genomic content arrangements and the ability to (re-)combine and (re-)regulate them according to context-dependent (i.e. adaptational) purposes of the host organism. PMID:21537469

  14. Pediatric surgical pathology. Second edition

    SciTech Connect

    Dehner, L.P.

    1987-01-01

    The edition provides view of congenital, hereditary, infectious, and inflammatory neoplastic diseases occurring during the first two decades of life, with special reference to clinical, laboratory, and roentgenographic features. Material includes observations from some of the major national studies on Wilms' tumor and rhabdomyosarcomas, the new classification of pediatric malignant lymphomas, a discussion of the role of immunocytochemistry as it applies to the diagnosis of childhood infections and neoplasms, an examination of graft-versus-host disease in the liver and intestinal tract and more.

  15. A comprehensive overview of computational resources to aid in precision genome editing with engineered nucleases.

    PubMed

    Periwal, Vinita

    2016-07-03

    Genome editing with engineered nucleases (zinc finger nucleases, TAL effector nucleases s and Clustered regularly inter-spaced short palindromic repeats/CRISPR-associated) has recently been shown to have great promise in a variety of therapeutic and biotechnological applications. However, their exploitation in genetic analysis and clinical settings largely depends on their specificity for the intended genomic target. Large and complex genomes often contain highly homologous/repetitive sequences, which limits the specificity of genome editing tools and could result in off-target activity. Over the past few years, various computational approaches have been developed to assist the design process and predict/reduce the off-target activity of these nucleases. These tools could be efficiently used to guide the design of constructs for engineered nucleases and evaluate results after genome editing. This review provides a comprehensive overview of various databases, tools, web servers and resources for genome editing and compares their features and functionalities. Additionally, it also describes tools that have been developed to analyse post-genome editing results. The article also discusses important design parameters that could be considered while designing these nucleases. This review is intended to be a quick reference guide for experimentalists as well as computational biologists working in the field of genome editing with engineered nucleases.

  16. Algebra Readiness Outcomes of Sixth-Grade Boys and Girls Placed in Challenge Math Based on Measured Math Ability Compared to Sixth-Grade Boys and Girls Placed in Challenge Math Based on Teachers' Recommendations

    ERIC Educational Resources Information Center

    Hemphill, David C.

    2011-01-01

    The first pretest-posttest hypothesis was tested using the dependent t test. Null hypotheses for test score improvement over time were rejected for the end of fifth-grade pretest compared to ending sixth-grade posttest math Essential Learner Outcome scores converted to standard scores for randomly selected sixth-grade girls meeting measured test…

  17. Self-Esteem and Adjusting with Blindness: The Process of Responding to Life's Demands. Third Edition

    ERIC Educational Resources Information Center

    Tuttle, Dean W.; Tuttle, Naomi R.

    2004-01-01

    This new and expanded Third Edition analyzes blindness within the context of two overlapping theoretical constructs: the development of self-esteem and the process of adjusting to social and/or physical trauma. The book is divided into four sections. The first section, provides an overview of blindness and the essential background for subsequent…

  18. Algebra Word Problem Solving Approaches in a Chemistry Context: Equation Worked Examples versus Text Editing

    ERIC Educational Resources Information Center

    Ngu, Bing Hiong; Yeung, Alexander Seeshing

    2013-01-01

    Text editing directs students' attention to the problem structure as they classify whether the texts of word problems contain sufficient, missing or irrelevant information for working out a solution. Equation worked examples emphasize the formation of a coherent problem structure to generate a solution. Its focus is on the construction of three…

  19. Psychometric Properties of the Chinese Self-Directed Search (1994 Edition)

    ERIC Educational Resources Information Center

    Yang, Weiwei; Lance, Charles E.; Hui, Harry C.

    2006-01-01

    In this study, we (a) examined the measurement equivalence/invariance (ME/I) of the Chinese Self-Directed Search (SDS; 1994 edition) across gender and geographic regions (Mainland China vs. Hong Kong); (b) assessed the construct validity of the Chinese SDS using Widaman's (1985, 1992) MTMM framework; and (c) determined whether vocational interests…

  20. Confirmatory Factor Analysis of the Stanford-Binet Fourth Edition: Testing the Theory-Test Match.

    ERIC Educational Resources Information Center

    Keith, Timothy Z.; And Others

    1988-01-01

    Studied whether Stanford-Binet Intelligence Scale: Fourth Edition corresponds to theory that guided its construction, using first-order confirmatory factor analysis with entire standardization sample and three age groups. Results generally support the four factors as reflecting the underlying structure of the new Binet, but were less supportive of…

  1. Confirmatory Factor Structure of the Kaufman Assessment Battery for Children-Second Edition: Consistency with Cattell-Horn-Carroll Theory

    ERIC Educational Resources Information Center

    Reynolds, Matthew R.; Keith, Timothy Z.; Fine, Jodene Goldenring; Fisher, Melissa E.; Low, Justin A.

    2007-01-01

    The Kaufman Assessment Battery for Children-Second Edition (KABC-II) is a departure from the original KABC in that it allows for interpretation via two theoretical models of intelligence. This study had two purposes: to determine whether the KABC-II measures the same constructs across ages and to investigate whether those constructs are…

  2. Environmental law handbook. Fifteenth edition

    SciTech Connect

    Sullivan, T.F.P.

    1999-04-01

    Written by 15 nationally recognized environmental legal experts, this new edition maintains the first edition's original goal to provide users with reliable, accurate, and practical compliance information by addressing all changes made to the laws in the past two years. Using clear language with a minimum of legal jargon, this essential 700-page reference provides readers with a foundation for understanding the obligations of the laws. This book also explains and details noncompliance penalties, including administrative fines and criminal prosecution for violation of all acts and newly increased fines for negligent violations of the Clean Water Act. The authors focus, however, on the 14 major environmental, health, and safety laws affecting US businesses and organizations and detail, in over 90 new pages, and all recent changes made to those laws. Such changes include explanations of the Joint EPA/State Innovations agreement, which the EPA and senior state environmental officials established and signed in 1998; the revised TSCA Model Reporting Rule, which took effect June 30, 1998; and RCRA's conditional regulation of waste military munitions, which went into effect August 12, 1997. In addition, this new handbook details the revised national ambient air quality standards for ozone and fine particles and the new and revised air toxics control requirements. Environmental managers, engineers, professionals, and students nationwide will benefit from the professional expertise, sample and cited cases, and straightforward explanations found in the pages of this comprehensive environmental law book, the industry standard for 26 years.

  3. CRISPR-Mediated Epigenome Editing

    PubMed Central

    Enríquez, Paul

    2016-01-01

    Mounting evidence has called into question our understanding of the role that the central dogma of molecular biology plays in human pathology. The conventional view that elucidating the mechanisms for translating genes into proteins can account for a panoply of diseases has proven incomplete. Landmark studies point to epigenetics as a missing piece of the puzzle. However, technological limitations have hindered the study of specific roles for histone post-translational modifications, DNA modifications, and non-coding RNAs in regulation of the epigenome and chromatin structure. This feature highlights CRISPR systems, including CRISPR-Cas9, as novel tools for targeted epigenome editing. It summarizes recent developments in the field, including integration of optogenetic and functional genomic approaches to explore new therapeutic opportunities, and underscores the importance of mitigating current limitations in the field. This comprehensive, analytical assessment identifies current research gaps, forecasts future research opportunities, and argues that as epigenome editing technologies mature, overcoming critical challenges in delivery, specificity, and fidelity should clear the path to bring these technologies into the clinic. PMID:28018139

  4. Urban Teaching: The Essentials. Third Edition

    ERIC Educational Resources Information Center

    Weiner, Lois; Jerome, Daniel

    2016-01-01

    This significantly revised edition will help prospective and new city teachers navigate the realities of city teaching. Now the classic introduction to urban teaching, this book explains how global, national, state, and local reforms have impacted what teachers need to know to not only survive, but to do their jobs well. The Third Edition melds…

  5. Non-GMO genetically edited crop plants.

    PubMed

    Kanchiswamy, Chidananda Nagamangala; Malnoy, Mickael; Velasco, Riccardo; Kim, Jin-Soo; Viola, Roberto

    2015-09-01

    Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome editing complex is degraded in the recipient cells.

  6. Exposure Factors Handbook 2011 Edition (Final Report) ...

    EPA Pesticide Factsheets

    EPA announced the release of the final report, Exposure Factors Handbook: 2011 Edition (EPA/600/R-09/052F), prepared by the Office of Research and Development's National Center for Environmental Assessments (NCEA). This updated edition of the handbook provides the most up-to-date data on the various human factors used in assessing exposure. The Exposure Factors Handbook (EFH or

  7. Automatic data editing: a brief introduction

    SciTech Connect

    Liepins, G.E.

    1982-01-01

    This paper briefly discusses the automatic data editing process: (1) check the data records for consistency, (2) analyze the inconsistent records to determine the inconsistent variables. It is stated that the application of automatic data editing is broad, and two specific examples are cited. One example, that of a vehicle maintenance data base is used to illustrate the process.

  8. Teaching Visually Impaired Children. 3rd Edition

    ERIC Educational Resources Information Center

    Bishop, Virginia E.

    2004-01-01

    In this exceptional new third edition, the author has retained much of the practical "how to" approach of the previous editions, but adds depth in two dimensions: learning theory and the educational process. This book is "so comprehensive in scope and complete in detail that it would be the most likely recommended" (from the foreword by Dr.…

  9. Exposure Factors Handbook 2011 Edition (Final Report)

    EPA Science Inventory

    EPA announced the release of the final report, Exposure Factors Handbook: 2011 Edition (EPA/600/R-09/052F), prepared by the Office of Research and Development's National Center for Environmental Assessments (NCEA). This updated edition of the handbook provides the most up...

  10. Managing the Incompetent Teacher. Second Edition.

    ERIC Educational Resources Information Center

    Bridges, Edwin M.

    Featuring the same practical guidelines for ridding schools of incompetent teachers as the 1984 edition, this new edition incorporates substantially revised material on three topics: criteria and information sources for evaluating teaching effectiveness, remediation procedures, and grounds for dismissal. The book presents an eight-step systematic,…

  11. Program For Editing Graphical Displays Of Schedules

    NASA Technical Reports Server (NTRS)

    Mulnix, Cassie L.; Miller, Kevin

    1995-01-01

    XOPPS is window-based software tool from graphics providing easy and fast "what you see is what you get" (WYSIWYG) on-screen editing capabilities. Provides area, analogous to canvas, displaying full image of schedule being edited. Canvas contains header area (for test) and schedule area (for plotting graphical representations of milestone objects in flexible time line). Written in C language.

  12. Applications of genome editing in insects

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Insect genome editing was first reported 1991 in Drosophila melanogaster but the technology used was not portable to other species. Not until the recent development of facile, engineered DNA endonuclease systems has gene editing become widely available to insect scientists. Most applications in inse...

  13. Novel modes of RNA editing in mitochondria

    PubMed Central

    Moreira, Sandrine; Valach, Matus; Aoulad-Aissa, Mohamed; Otto, Christian; Burger, Gertraud

    2016-01-01

    Gene structure and expression in diplonemid mitochondria are unparalleled. Genes are fragmented in pieces (modules) that are separately transcribed, followed by the joining of module transcripts to contiguous RNAs. Some instances of unique uridine insertion RNA editing at module boundaries were noted, but the extent and potential occurrence of other editing types remained unknown. Comparative analysis of deep transcriptome and genome data from Diplonema papillatum mitochondria reveals ∼220 post-transcriptional insertions of uridines, but no insertions of other nucleotides nor deletions. In addition, we detect in total 114 substitutions of cytosine by uridine and adenosine by inosine, amassed into unusually compact clusters. Inosines in transcripts were confirmed experimentally. This is the first report of adenosine-to-inosine editing of mRNAs and ribosomal RNAs in mitochondria. In mRNAs, editing causes mostly amino-acid additions and non-synonymous substitutions; in ribosomal RNAs, it permits formation of canonical secondary structures. Two extensively edited transcripts were compared across four diplonemids. The pattern of uridine-insertion editing is strictly conserved, whereas substitution editing has diverged dramatically, but still rendering diplonemid proteins more similar to other eukaryotic orthologs. We posit that RNA editing not only compensates but also sustains, or even accelerates, ultra-rapid evolution of genome structure and sequence in diplonemid mitochondria. PMID:27001515

  14. Exposure Factors Handbook 2011 Edition (Final)

    EPA Science Inventory

    edition_cover.jpg" vspace = "5" hspace="5" align="right" border="2" alt="Cover of the Exposure Factors Handbook: 2011 Edition"> The mission of National Center for Environmental Assessment (NCEA) of EPA's ...

  15. Sex Differences in Cognitive Abilities. Fourth Edition

    ERIC Educational Resources Information Center

    Halpern, Diane F.

    2011-01-01

    The fourth edition of "Sex Differences in Cognitive Abilities" critically examines the breadth of research on this complex and controversial topic, with the principal aim of helping the reader to understand where sex differences are found--and where they are not. Since the publication of the third edition, there have been many exciting and…

  16. Accounting for Independent Schools. Second Edition.

    ERIC Educational Resources Information Center

    National Association of Independent Schools, Boston, MA.

    This is a thoroughly revised edition of the 1969 publication, "Accounting for Independent Schools," a guide that attempted to codify basic accounting principles and practices for specific application to independent schools. The focus of the second edition is more on refining practices than on initiating them, and more on extending the managerial…

  17. Editing Technical Proposals (The Friendly Editor).

    ERIC Educational Resources Information Center

    Bush, Don

    1994-01-01

    Makes suggestions for editing technical proposals. Discusses the marketeers, the hierarchy of hype, how to save days, managing story boards, expediting a laborious process, teaching engineers to write, writing incrementally, the art group, and the editing task. Argues that the best proposals come from starting to write early. (SR)

  18. America's Children and the Environment, Third Edition

    EPA Science Inventory

    America's Children and the Environment is the U.S. EPA's report of children's environmental health indicators. Two editions of the report have been published, in 2000 and 2003, and a website is maintained with updated values for the indicators. The new Third Edition of America'...

  19. Vertical Hegelianism and Beyond: Digital Cinema Editing.

    ERIC Educational Resources Information Center

    Wyatt, Roger B.

    Cinema as an art and communication form is entering its second century of development. Sergei Eisenstein conceived of editing in horizontal and vertical terms. He saw vertical editing patterns primarily as the synchronization of simultaneous image and sound elements, particularly music, no create cinematic meaning by means of the relationship…

  20. Educational Assessment of Students. Third Edition.

    ERIC Educational Resources Information Center

    Nitko, Anthony J.

    This text offers teachers and education majors practical, step-by-step guidance on how to create and use assessments. It can serve as the textbook for an undergraduate or first graduate course in educational assessment. This third edition focuses more clearly on classroom assessment than the previous editions. Each chapter has been revised with…

  1. FYI: For Your Improvement, Fourth Edition

    ERIC Educational Resources Information Center

    Lombardo, Michael M.; Eichinger, Robert W.

    2004-01-01

    FYI For Your Improvement (4th Edition) provides step-by-step guidance for anyone who wants to develop new competencies or for anyone working with another person on their development. This edition contains: Introduction; Strategies for Improvement; General Development Plan; Organization for "FYI For Your Improvement"; Competencies; Performance…

  2. Web Thermo Tables (WTT) - Professional Edition

    National Institute of Standards and Technology Data Gateway

    SRD 203 NIST/TRC Web Thermo Tables (WTT) - Professional Edition (Online Subscription)   WTT - Professional Edition, a Web version of the TRC Thermodynamic Tables, represents a complete collection of critically evaluated thermodynamic property data primarily for pure organic compounds. As of Nov. 2011, WTT contains information on 23999 compounds.

  3. Web Thermo Tables (WTT) - Lite Edition

    National Institute of Standards and Technology Data Gateway

    SRD 202 NIST/TRC Web Thermo Tables (WTT) - Lite Edition (Online Subscription)   WTT - Lite Edition, a Web version of the TRC Thermodynamic Tables, represents a collection of critically evaluated thermodynamic property data for 150 commonly-used (primarily organic) pure compounds.

  4. Genetic Architectures of Quantitative Variation in RNA Editing Pathways.

    PubMed

    Gu, Tongjun; Gatti, Daniel M; Srivastava, Anuj; Snyder, Elizabeth M; Raghupathy, Narayanan; Simecek, Petr; Svenson, Karen L; Dotu, Ivan; Chuang, Jeffrey H; Keller, Mark P; Attie, Alan D; Braun, Robert E; Churchill, Gary A

    2016-02-01

    RNA editing refers to post-transcriptional processes that alter the base sequence of RNA. Recently, hundreds of new RNA editing targets have been reported. However, the mechanisms that determine the specificity and degree of editing are not well understood. We examined quantitative variation of site-specific editing in a genetically diverse multiparent population, Diversity Outbred mice, and mapped polymorphic loci that alter editing ratios globally for C-to-U editing and at specific sites for A-to-I editing. An allelic series in the C-to-U editing enzyme Apobec1 influences the editing efficiency of Apob and 58 additional C-to-U editing targets. We identified 49 A-to-I editing sites with polymorphisms in the edited transcript that alter editing efficiency. In contrast to the shared genetic control of C-to-U editing, most of the variable A-to-I editing sites were determined by local nucleotide polymorphisms in proximity to the editing site in the RNA secondary structure. Our results indicate that RNA editing is a quantitative trait subject to genetic variation and that evolutionary constraints have given rise to distinct genetic architectures in the two canonical types of RNA editing.

  5. RNA editing and drug discovery for cancer therapy.

    PubMed

    Huang, Wei-Hsuan; Tseng, Chao-Neng; Tang, Jen-Yang; Yang, Cheng-Hong; Liang, Shih-Shin; Chang, Hsueh-Wei

    2013-01-01

    RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.

  6. [Tale nucleases--new tool for genome editing].

    PubMed

    Glazkova, D V; Shipulin, G A

    2014-01-01

    The ability to introduce targeted changes in the genome of living cells or entire organisms enables researchers to meet the challenges of basic life sciences, biotechnology and medicine. Knockdown of target genes in the zygotes gives the opportunity to investigate the functions of these genes in different organisms. Replacement of single nucleotide in the DNA sequence allows to correct mutations in genes and thus to cure hereditary diseases. Adding transgene to specific genomic.loci can be used in biotechnology for generation of organisms with certain properties or cell lines for biopharmaceutical production. Such manipulations of gene sequences in their natural chromosomal context became possible after the emergence of the technology called "genome editing". This technology is based on the induction of a double-strand break in a specific genomic target DNA using endonucleases that recognize the unique sequences in the genome and on subsequent recovery of DNA integrity through the use of cellular repair mechanisms. A necessary tool for the genome editing is a custom-designed endonuclease which is able to recognize selected sequences. The emergence of a new type of programmable endonucleases, which were constructed on the basis of bacterial proteins--TAL-effectors (Transcription activators like effector), has become an important stage in the development of technology and promoted wide spread of the genome editing. This article reviews the history of the discovery of TAL effectors and creation of TALE nucleases, and describes their advantages over zinc finger endonucleases that appeared earlier. A large section is devoted to description of genetic modifications that can be performed using the genome editing.

  7. Physical Activity of Fifth to Sixth Graders during School Hours According to School Race/Ethnicity: Suburban Cook County, Illinois

    ERIC Educational Resources Information Center

    Kwon, Soyang; Mason, Maryann; Welch, Sarah

    2015-01-01

    Background: We compared moderate-to-vigorous intensity physical activity (MVPA) and inactivity levels among fifth and sixth graders during school hours according to school-level race/ethnicity and income attributes to inform school-based obesity interventions in Illinois Suburban Cook County (SCC). Methods: Fifth- and sixth-grade students…

  8. Examining Sixth Grade Students' Reading Attitudes and Perceptions of Teacher Read Aloud: Are All Students on the Same Page?

    ERIC Educational Resources Information Center

    Clark, Sarah K.; Andreasen, Lindi

    2014-01-01

    The purpose of this embedded mixed methods study was to examine how sixth graders with high and low reading attitudes perceive teacher read aloud. We utilized quantitative data by surveying sixth graders (N = 87) about their reading attitudes and then collected qualitative data by interviewing five students, interviewing the teacher, conducting…

  9. An Investigation of Play: From the Voices of Fifth- and Sixth-Grade Talented and Gifted Students

    ERIC Educational Resources Information Center

    Beisser, Sally Rapp; Gillespie, Catherine Wilson; Thacker, Valerie Marsh

    2013-01-01

    The purpose of this study was to explore the concept of play through the eyes of talented and gifted (TAG) fifth- and sixth-grade students. Three focus groups consisting of fifth- and sixth-grade TAG students were conducted in one urban, one suburban, and one rural school district in the Midwest. Students were asked to describe the value of play…

  10. Development of a Multidimensional Thinking Styles Scale Based on Theory of Mental Self-Government for Sixth Grade Students

    ERIC Educational Resources Information Center

    Chaiyapornpattana, Niorn; Wongwanich, Suwimon

    2013-01-01

    This study designed 1) to develop a multidimensional thinking styles scale based on theory of mental self-government for sixth grade student 2) to investigate quality of the developed scale 3) to study profile of styles of sixth grade student and a relation of profile of styles of student in each dimension and background of gender and grade with…

  11. Investigation of the Relationship between the Spatial Visualization Success and Visual/Spatial Intelligence Capabilities of Sixth Grade Students

    ERIC Educational Resources Information Center

    Yenilmez, Kursat; Kakmaci, Ozlem

    2015-01-01

    The main aim of this research was to examine the relationship between the spatial visualization success and visual/spatial intelligence capabilities of sixth grade students. The sample of the research consists of 1011 sixth grade students who were randomly selected from the primary schools in Eskisehir. In this correlational study, data were…

  12. 8 CFR 1212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 1212.9 Section 1212.9 Aliens... immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who is also a graduate of a medical school as defined by section 101(a)(41) of...

  13. 8 CFR 1212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 1212.9 Section 1212.9 Aliens... immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who is also a graduate of a medical school as defined by section 101(a)(41) of...

  14. 8 CFR 1212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 1212.9 Section 1212.9 Aliens... immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who is also a graduate of a medical school as defined by section 101(a)(41) of...

  15. 8 CFR 1212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 1212.9 Section 1212.9 Aliens... immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who is also a graduate of a medical school as defined by section 101(a)(41) of...

  16. 8 CFR 1212.9 - Applicability of section 212(a)(32) to certain derivative third and sixth preference and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certain derivative third and sixth preference and nonpreference immigrants. 1212.9 Section 1212.9 Aliens... immigrants. A derivative beneficiary who is the spouse or child of a qualified third or sixth preference or nonpreference immigrant and who is also a graduate of a medical school as defined by section 101(a)(41) of...

  17. RNA editing in human cancer: review.

    PubMed

    Skarda, Jozef; Amariglio, Ninette; Rechavi, Gideon

    2009-08-01

    In eukaryotes mRNA transcripts are extensively processed by different post-transcriptional events such as alternative splicing and RNA editing in order to generate many different mRNAs from the same gene, increasing the transcriptome and then the proteome diversity. The most frequent RNA editing mechanism in mammals involves the conversion of specific adenosines into inosines by the ADAR family of enzymes. This editing event can alter the sequence and the secondary structure of RNA molecules, with consequences for final proteins and regulatory RNAs. Alteration in RNA editing has been connected to tumor progression and many other important human diseases. Analysis of many editing sites in various cancer types is expected to provide new diagnostic and prognostic markers and might contribute to early detection of cancer, the monitoring of response to therapy, and to the detection of minimal residual disease.

  18. Chickscope Realized: A Situated Evaluation of a Sixth-Grade Classroom.

    ERIC Educational Resources Information Center

    Hogan, Maureen P.

    2000-01-01

    This is a case study of two sixth-grade teachers from Illinois who participated in a semester-long inservice to learn about Chickscope, a supercomputing application that allows students and teachers remote access to magnetic resonance images of chicken embryos. Shows how they produced an inquiry-based unit on chicken weight and measurement.…

  19. Improving Motivation of Sixth Grade Music Students through Curriculum Interventions and Teaching Practices.

    ERIC Educational Resources Information Center

    Outis, Janet

    This report describes a program for improving the motivation of sixth grade students in the music class and for increasing their understanding of the relevancy of music in their total curriculum. The students are part of a low to middle class suburban community located in northeastern Illinois. The problem was noted originally by the music teacher…

  20. Mission US and Historical Empathy: A Qualitative Case Study of Sixth-Grade Students' Experiences

    ERIC Educational Resources Information Center

    Maxlow, James Richard

    2015-01-01

    This study investigated the potential development and use of historical empathy in sixth-grade students while using the colonial-era historical education game "Mission US" and its associated learning activities. A collective case study was developed to describe and interpret students' experiences. The gathered data included the students'…

  1. 77 FR 25524 - Sixth Meeting: RTCA, NextGen Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... Federal Aviation Administration Sixth Meeting: RTCA, NextGen Advisory Committee AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of a meeting of RTCA, NextGen... RTCA, NextGen Advisory Committee. DATES: The meeting will be held May 24, 2012, from 9:00 a.m.-3:00...

  2. Derivational Morphological Awareness, Academic Vocabulary, and Reading Comprehension in Linguistically Diverse Sixth Graders

    ERIC Educational Resources Information Center

    Kieffer, Michael J.; Box, Catherine DiFelice

    2013-01-01

    This study investigated the multiple roles of morphological awareness in reading comprehension for Spanish-speaking language minority (LM) learners and their native English-speaking (NE) peers. Sixth-grade students (N = 137; 82 LM, 55 NE) were assessed on English measures of derivational morphological awareness, morphologically complex academic…

  3. Two Studies of Tier II Literacy Development: Throwing Sixth Graders a Lifeline

    ERIC Educational Resources Information Center

    Graves, Anne W.; Duesbery, Luke; Pyle, Nicole B.; Brandon, Regina R.; McIntosh, Angela S.

    2011-01-01

    Two experimental studies at one urban middle school investigated the effects of the combination of Tier I and Tier II evidence-based reading instruction compared to Tier I alone on struggling sixth-grade readers (N = 109). All participants received free or reduced-price lunch, and 95% were considered English learners at some point in their school…

  4. An Evaluation of the Cooperative Learning Process by Sixth-Grade Students

    ERIC Educational Resources Information Center

    Genç, Murat

    2016-01-01

    The purpose of this study is to investigate the effectiveness of cooperative learning on the science lessons achievement of primary school students and to designate their views on cooperative learning process. 135 sixth-grade students attending the same school took part in the study. The model of this study was the Solomon four-group model. In the…

  5. Water: A Vital Resource. Environmental Education Supplementary Instructional Guide. Sixth Grade Level.

    ERIC Educational Resources Information Center

    Young, Donald B.; And Others

    Water related activities for sixth-grade students are presented as one possible way to incorporate environmental education into the existing curriculum of Hawaii schools. Designed as an interdisciplinary approach, the activities integrate numerous thematic and subject areas to teach that fresh water is a limited but vital natural resource. Topics…

  6. STS-6 sixth Space Shuttle mission. First flight of the Challenger

    NASA Technical Reports Server (NTRS)

    1983-01-01

    A prelaunch summary of the sixth Space Shuttle mission is provided. The Challenger orbiter; launching; uprated engines; lighter weight boosters; lightweight tank; external tank reduction; landing; the tracking and data relay satellite system (TDRSS), TDRS-1 deployment; the inertial upper stage (IUS), the spacewalk;electrophoresis, monodisperse latex reactor, night time/day time optical survey of lightning, and getaway special experiments are described.

  7. Anxiety, Intelligence, and Classroom Structure Effects on Reading Achievement in Sixth and Seventh Grade.

    ERIC Educational Resources Information Center

    Binder, Barry

    Hypotheses derived from Hull-Spence learning theory were tested in an investigation of the interactions of anxiety, intelligence, and classroom structure. After pretesting using the Lorge-Thorndike Intelligence Test and the Children's Manifest Anxiety Scale (CMAS), the 324 sixth graders and seventh graders were assigned to one of the eight…

  8. Advances in berry research: the sixth biennial berry health benefits symposium

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Studies to advance the potential health benefits of berries continue to increase as was evident at the sixth biennial meeting of the Berry Health Benefits Symposium (BHBS). The two and a half-day symposium was held on October 13-15, 2015, in Madison, Wisconsin, United States. The 2015 BHBS feature...

  9. 75 FR 61756 - Sixth Meeting of the Advisory Committee for the 2012 World Radiocommunication Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... COMMISSION Sixth Meeting of the Advisory Committee for the 2012 World Radiocommunication Conference AGENCY... continue preparations for the 2012 World Radiocommunication Conference. The WRC- 12 Advisory Committee will... recommendations relating to the preparation of United States proposals and positions for the 2012...

  10. Reading Comprehension of Sixth Grade, Good and Poor Readers: A Developmental and Methodological Investigation.

    ERIC Educational Resources Information Center

    Sawyer, Myrtie L.; And Others

    To understand better how readers learn and recall text information, a study examined one prose learning approach--the selective attention strategy (SAS)--in which text elements are processed, given various degrees of attention, and learned according to their perceived importance. Fifty sixth grade students from an inner city school in a large…

  11. The Effects of a Water Conservation Instructional Unit on the Values Held by Sixth Grade Students

    ERIC Educational Resources Information Center

    Aird, Andrew; Tomera, Audrey

    1977-01-01

    Sixth grade students were divided into two groups. Students in one group received instruction on water conservation using expository and discovery activities. The students in the control group received none. Results gave evidence that students' values could be changed by this mode of water conservation instruction. (MA)

  12. A Study of Sixth-graders Energy Attitudes: Evaluation of an Energy Module.

    ERIC Educational Resources Information Center

    Barrow, Lloyd H.

    Reported is a study of sixth-graders' attitudes towards electrical energy. Students in Catawba County, North Carolina schools, which field-tested the Energy for Today and Tomorrow (EFTT) module, completed a 17-item attitude test, the Environmental Opinion Scale. This instrument measured opinions regarding nuclear power, electrical power…

  13. Destination Graduation: Sixth Grade Early Warning Indicators for Baltimore City Schools. Their Prevalence and Impact

    ERIC Educational Resources Information Center

    Baltimore Education Research Consortium, 2011

    2011-01-01

    Even with the declining number of dropouts in Baltimore City, a focus on dropout prevention is essential. Recent research has emphasized the utility of an early warning system to inform prevention efforts. With this in mind, the Baltimore Education Research Consortium examined the 2000-01 cohort of sixth grade students (Class of 2007) from the…

  14. A Stitch in Time: Gender Issues Explored through Contemporary Textiles Practice in a Sixth Form College

    ERIC Educational Resources Information Center

    Hyde, Wendy

    2007-01-01

    This article discusses, contextualises and locates in contemporary theory, an autobiographical case study of an artist-teacher in the "learning community" of a Sixth Form College art department. It reflects on the educational potential of enabling teachers of art and their students to investigate issues of culture and identity through engaging…

  15. VIEW OF THE ARENA STAGE/KREEGER THEATER AT 1101 SIXTH STREET; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE ARENA STAGE/KREEGER THEATER AT 1101 SIXTH STREET; HARRY WEESE & ASSOCIATES DESIGNED THE ARENA STAGE IN 1961 AND THE KREEGER THEATER IN 1970 - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  16. Mathematical Communications: Elementary Pre-Service Teachers' E-Mail Exchanges with Sixth Grade Students

    ERIC Educational Resources Information Center

    Tunc-Pekkan, Zelha; D'Ambrosio, Beatriz S.

    2009-01-01

    This study examines the communication between pre-service teachers and sixth grade students in a project in which email was used for communication as students learned about fractions and were supported by the pre-service teachers. Specifically, the study investigated how the pre-service teachers applied their mathematical knowledge to understand…

  17. Effects of Reading Technology Integration on Sixth Grade Test and Reading Scores

    ERIC Educational Resources Information Center

    Thomas, P. Ann

    2012-01-01

    The focus of the investigation is on a sixth grade population not performing reading on grade level and not achieving high-stakes test score proficiency causing the school to fail adequate yearly progress (AYP). The lack of reading skills causes the students to repeat grades in middle school and high school. Reading technology instruction is the…

  18. Negotiating Discourses: Sixth-Grade Students' Use of Multiple Science Discourses during a Science Fair Presentation

    ERIC Educational Resources Information Center

    Gomez, Kimberley

    2007-01-01

    This study offers important insights into the coexistence of multiple discourses and the link between these discourses and science understanding. It offers concrete examples of students' movement between multiple discourses in sixth-grade science fair presentations, and shows how those multiple discourses in science practices illuminate students'…

  19. Looking Out Is In: 12 Lesson Television Series for Sixth Grade Anthropology. Teacher Guides.

    ERIC Educational Resources Information Center

    Cooperative Educational Service Agency 13, Waupun, WI.

    Teacher developed guides for a twelve-unit series on anthropology at the sixth grade level are outlined. Although these materials were designed to accompany a lesson on a state instructional television network they can be utilized to a degree without the video experience. Topics of the units consist of what is anthropology; what is culture; why is…

  20. Instructional Television: Inquiry Method of Instruction in Fifth- and Sixth-Grade Science.

    ERIC Educational Resources Information Center

    Beets, Mary Mitchell

    The primary purpose of this study was to evaluate television as an instructional medium for teaching creative thinking to fifth and sixth grade students by use of the "inquiry" method of instruction in the area of science. A secondary purpose was to determine the effect of student involvement in the live telecasts on their performance on a test…

  1. A Social-Cognitive Developmental Intervention with Sixth and First Graders.

    ERIC Educational Resources Information Center

    Enright, Robert D.; And Others

    This study examined the effects of a cross-age training program on the interpersonal conceptions of the students serving as trainers. A total of 24 sixth graders participated in the study, 12 in the training group and 12 in the control group which received no training. The training group met twice a week, once to lead dilemma discussion groups…

  2. Science Achievement of Costa Rican Sixth Grade Students and Its Relationship with Selected Variables.

    ERIC Educational Resources Information Center

    Esquivel-Alfaro, Juan Manuel; Diaz-Solis, Sofia Maria

    This study had three purposes. First, to develop and validate a criterion-referenced test to measure science knowledge of students who finished the second cycle of the Basic General Education (6th grade). Second, to assess the performance of the entire Costa Rican population of sixth graders and, third, to analyze the results according to some…

  3. All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting.

    PubMed

    Weller, Caroline E; Chatterjee, Champak

    2015-11-01

    Endless potential: The sixth Chemical Protein Synthesis Meeting, held recently in St. Augustine, Florida, showed the potential of peptide and protein chemistry when applied toward understanding and controlling complex biological processes. This report highlights the diverse and cutting-edge protein chemistry presented at the meeting.

  4. Galveston Elementary School: A Study of a Sixth Grade Literature-Based Reading Program. Final Report.

    ERIC Educational Resources Information Center

    Robbins, Edward L.; Thompson, Linda W.

    A study examined the effectiveness of a pilot literature-based reading program. Subjects, sixth grade students at Galveston Elementary School, were grouped into high, middle, and low ability groups containing 20, 25, and 13 students respectively. Reading instruction was provided during 45-minute class periods 5 times each week. Instruction…

  5. An Investigation of Mathematics Anxiety among Sixth through Eighth Grade Students in Turkey

    ERIC Educational Resources Information Center

    Birgin, Osman; Baloglu, Mustafa; Catlioglu, Hakan; Gurbuz, Ramazan

    2010-01-01

    The purpose of the present study is to investigate mathematics anxiety among 220 sixth through eighth grade Turkish students in terms of mathematics achievement levels, perceived enjoyment of the mathematics teaching method, perceived enjoyment of mathematics, and perceived help with mathematics from parents. The Mathematics Anxiety Scale for…

  6. Comparison of Writing Anxiety and Writing Dispositions of Sixth, Seventh and Eighth Grade Students

    ERIC Educational Resources Information Center

    Berk, Rifat Ramazan; Ünal, Emre

    2017-01-01

    The purpose of this study is to determine sixth, seventh and eighth grade students' writing anxiety and dispositions and to examine to what extent they predict each other. The basis of this study is to determine whether writing disposition is the significant predictor of writing anxiety or not and whether students' grade levels and genders are…

  7. Will Words Ever Harm Me? Escalation from Verbal to Physical Abuse in Sixth-Grade Classrooms

    ERIC Educational Resources Information Center

    Geiger, Brenda; Fischer, Michael

    2006-01-01

    Based on in-depth qualitative interviews, this article gives the opportunity to 145 sixth graders to tell, in their own words, how they felt and reacted when verbally and emotionally abused by their classmates. Content analysis of interviews revealed gender differences in students reactions to verbal aggression. Another interesting finding was the…

  8. Egg-citing Sixth Graders in Science: A Creative Activity in Cell Structure

    ERIC Educational Resources Information Center

    Mersch, Margaret; Bryant, Napolean, Jr.

    1976-01-01

    Sixth-grade pupils at St. Vivian's school recently studied a science lesson on distinguishing between plant and animal cells. Observation of pupils indicated that learning was occurring, but the enthusiasm they had exhibited in earlier science lessons was obviously lacking. Article discussed a model, designed to stimulate learning processes, from…

  9. The Influences of the Sixth Graders' Parents' Internet Literacy and Parenting Style on Internet Parenting

    ERIC Educational Resources Information Center

    Lou, Shi-Jer; Shih, Ru-Chu; Liu, Hung-Tzu; Guo, Yuan-Chang; Tseng, Kuo-Hung

    2010-01-01

    This study aims to explore the sixth grade students' parents' Internet literacy and parenting style on Internet parenting in Kaohsiung County in Taiwan. Upon stratified cluster sampling, a total of 822 parents from 34 classes in 28 schools participated in this study. The descriptive statistics and chi-square test were used to analyze the responses…

  10. A Study of Teaching and Learning Number Sense for Sixth Grade Students in Taiwan

    ERIC Educational Resources Information Center

    Yang, Der-Ching; Hsu, Chun-Jen; Huang, Ming-Chiang

    2004-01-01

    Two public schools (A and B) from two cities in southern Taiwan were selected to participate in this study. In each school, two sixth grade classes (an experimental and a control class) were studied. Number sense activities were conducted in the experimental classes through process-oriented teaching model to help children develop number sense,…

  11. Perspectives on the Teaching of Mathematics. Sixty-Sixth Yearbook [with Companion Guidebook

    ERIC Educational Resources Information Center

    Rubenstein, Rheta N., Ed.

    2004-01-01

    Teaching is a complex, ongoing endeavor that involves a myriad of decisions. The National Council of Teachers of Mathematics' (NCTM's) Sixty-Sixth Yearbook is organized around three aspects of teaching: foundations for teaching, the enactment of teaching, and the support of teaching nurtured in preservice education and strengthened throughout a…

  12. Environmental Quality, the Sixth Annual Report of the Council on Environmental Quality.

    ERIC Educational Resources Information Center

    Council on Environmental Quality, Washington, DC.

    This sixth annual report discusses the state of the environment and progress accomplished in meeting the goals and objectives established for an improved environment. Each of the seven chapters deals with an important environmental parameter. Chapter one is devoted to carcinogens in the environment. Chapter two presents perspectives on the…

  13. An Exploratory Study of Face-to-Face and Cyberbullying in Sixth Grade Students

    ERIC Educational Resources Information Center

    Accordino, Denise B.; Accordino, Michael P.

    2011-01-01

    In a pilot study, sixth grade students (N = 124) completed a questionnaire assessing students' experience with bullying and cyberbullying, demographic information, quality of parent-child relationship, and ways they have dealt with bullying/cyberbullying in the past. Two multiple regression analyses were conducted. The multiple regression analysis…

  14. Career Education English: Units for Career Exploration in Sixth, Seventh or Eighth Grade.

    ERIC Educational Resources Information Center

    Robinson, Mary

    The guide, designed for sixth, seventh, or eighth grade teachers and students presents six English instructional units for career exploration related to the occupational clusters transportation, communication (2), manufacturing, health, and business and office occupations. The units deal specifically with: the world of travel, the world of…

  15. The Effect of Shared Reading on Sixth Grade Students' Motivation to Read and Reading Comprehension

    ERIC Educational Resources Information Center

    Hollimon, Deborah Neal

    2008-01-01

    The purpose of this study was to examine whether there are changes in student motivation to read and reading comprehension when the instructional strategy of shared reading is used with sixth grade students. The quasi-experimental design for the study was based on the pretest-posttest nonequivalent control group design. The sample for the study…

  16. Collision of the First and Sixth Amendments: Direct Restraints vs. Alternative Remedies. An Update.

    ERIC Educational Resources Information Center

    Cohodas, Nadine

    The clash between the First and Sixth Amendments continues to be a major concern for both journalists and the courts. This paper reviews the major cases in the evolution of the "fair trial/free press" controversy from the "Irvin vs. Dowd" decision in 1961 to the Blackmun decision in 1975. The attempt is made to answer the…

  17. A Structural Equation Model of the Writing Process in Typically-Developing Sixth Grade Children

    ERIC Educational Resources Information Center

    Koutsoftas, Anthony D.; Gray, Shelley

    2013-01-01

    The purpose of this study was to evaluate how sixth grade children planned, translated, and revised written narrative stories using a task reflecting current instructional and assessment practices. A modified version of the Hayes and Flower (1980) writing process model was used as the theoretical framework for the study. Two hundred one…

  18. Problem Solving, Recall, and Isomorphic Transfer among Third-Grade and Sixth-Grade Children.

    ERIC Educational Resources Information Center

    Gholson, Barry; And Others

    1987-01-01

    Explores third and sixth grade children's acquisition and analogical transfer of the base of a relatively complex problem. One group at each grade level received two analogs of a scheduling problem; other groups received only one analog or a transfer task. After criterial performance, all children were transferred to an isomorphic analog and…

  19. The Effects of Two Outdoor Education Programs on Knowledge and Attitudes of Selected Sixth Graders.

    ERIC Educational Resources Information Center

    Ford, Phyllis M.; Payne, Philip G.

    1986-01-01

    Compares effect of two different outdoor education programs (Van Matre's Sunship Earth and a traditional nature study program focusing on plants, animals, water, and soil) on attitudes and knowledge of 266 selected Washington County (Oregon) sixth graders attending a five-day residential outdoor school program. (NEC)

  20. Integrating the Fulbright Mexico Summer Seminar into Sixth Grade Social Studies and Language Arts.

    ERIC Educational Resources Information Center

    Hetzler, H. Jeannine

    These lessons on Mexico have been taught in an integrated fashion within a sixth grade language arts and social studies classroom. Lessons are intended to be easy to pick up and use by any teacher. The material includes: (1) Rationale; (2) "Lesson 1 - I'll Bet You Can Map the Western Hemisphere in a Minute!"; (3) "Lesson 2 -…

  1. Relationships between Sixth-Graders' Reading Comprehension and Two Different Measures of Print Exposure

    ERIC Educational Resources Information Center

    Spear-Swerling, Louise; Brucker, Pamela O.; Alfano, Michael P.

    2010-01-01

    This study examined sixth-graders' reading comprehension and component reading abilities in relation to two measures of print exposure: an author recognition test (ART) involving fiction authors and a reading habits questionnaire (RHQ) about children's voluntary reading for enjoyment across various genres. The ART correlated only with children's…

  2. Sixth BHD Symposium and First International Upstate Kidney Cancer Symposium: latest scientific and clinical discoveries.

    PubMed

    Bratslavsky, Gennady; Woodford, Mark R; Daneshvar, Michael; Mollapour, Mehdi

    2016-03-29

    The Sixth BHD Symposium and First International Upstate Kidney Cancer Symposium concluded in September 2015, in Syracuse, NY, USA. The program highlighted recent findings in a variety of areas, including drug development, therapeutics and surgical management of patients with BHD and multi-focal renal tumors, as well as multidisciplinary approaches for patients with localized, locally advanced and metastatic renal cell carcinoma.

  3. Academic Achievement of Ugandan Sixth Grade Students: Influence of Parents' Education Levels

    ERIC Educational Resources Information Center

    Wamala, Robert; Kizito, Omala Saint; Jjemba, Evans

    2013-01-01

    The study investigates the influence of a father and mother's education on the academic achievement of their child. The investigation is based on data sourced from the 2009 Southern African Consortium for Monitoring Education Quality survey comprising 5,148 records of sixth grade students enrolled in Ugandan primary schools. Students' percentage…

  4. Proceedings of the sixth international symposium on methodologies for intelligent systems (Poster Session)

    SciTech Connect

    Harber, K.S.

    1991-09-01

    This volume contains papers which have been selected for the poster Session at the Sixth International Symposium for Intelligent Systems held October 1991, The following major areas were covered: expert systems; intelligent databases; knowledge representation; learning and adaptive systems; and logic for artificial intelligence. Nineteen full papers are included. (GHH)

  5. Distributing Leadership in English Sixth Form Colleges: Liberation or Another Form of Managerial Control?

    ERIC Educational Resources Information Center

    Stoten, David William

    2015-01-01

    Purpose: The purpose of this paper is to explore the distribution of leadership practices in Sixth Form Colleges (SFCs). This is an area where very little research has been undertaken and the intention was to investigate the topic from a critical perspective using social constructionist methodology. Design/methodology/approach: The research…

  6. 78 FR 16031 - Sixth Meeting: RTCA Special Committee 227, Standards of Navigation Performance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... TRANSPORTATION Federal Aviation Administration Sixth Meeting: RTCA Special Committee 227, Standards of Navigation...: Meeting Notice of RTCA Special Committee 227, Standards of Navigation Performance. SUMMARY: The FAA is..., Standards of Navigation Performance. DATES: The meeting will be held April 8-17, 2013 from 9:00 a.m.-5:00...

  7. An Analysis of Global Problems Issues in Sixth and Seventh Grade Science Textbooks.

    ERIC Educational Resources Information Center

    Hamm, Mary; Adams, Dennis

    The study examines the extent to which the global issues of population growth, world hunger, air quality and atmosphere, and water resources were treated in sixth and seventh grade science textbooks. Ten textbooks were examined by five raters to determine the amount of content presented by different textbooks on global issues, the number of pages…

  8. Playing It Safe: The Sixth Nationwide Safety Survey of Public Playgrounds.

    ERIC Educational Resources Information Center

    Weintraub, Rachel; Cassady, Alison

    The sixth nationwide investigation of public playgrounds by the Consumer Federation ofAmerica (CFA) and the State Public Interest Research Groups (PIRGs) found that amajority of U.S. playgrounds pose hidden threats to youngsters. From March-May 2002, the State PIRGs and other CFA member organizations investigated 1,037 playgrounds in 36 states…

  9. Exploring Music Practice among Sixth-Grade Band and Orchestra Students

    ERIC Educational Resources Information Center

    Austin, James R.; Berg, Margaret Haefner

    2006-01-01

    The purpose of this study was to describe the practice motivation and regulation of sixth-grade instrumentalists (11-12 years of age). A sample of 224 US band and orchestra students, representing 85 elementary schools, completed a 36-item practice inventory and produced two narratives depicting a typical practice session and a practice episode…

  10. Sixth Graders and Non-Routine Problems: Which Strategies Are Decisive for Success?

    ERIC Educational Resources Information Center

    Yazgan, Yeliz

    2015-01-01

    This study investigated the role of each strategy in explaining sixth graders' (12-13 years old students') non-routine problem solving success and discriminating between successful and unsuccessful students. Twelve non-routine problems were given to 123 pupils. Answers were scored between 0 and 10. Bottom and top segments of 27% were then…

  11. Problem Solving vs. Troubleshooting Tasks: The Case of Sixth-Grade Students Studying Simple Electric Circuits

    ERIC Educational Resources Information Center

    Safadi, Rafi'; Yerushalmi, Edit

    2014-01-01

    We compared the materialization of knowledge integration processes in class discussions that followed troubleshooting (TS) and problem-solving (PS) tasks and examined the impact of these tasks on students' conceptual understanding. The study was conducted in two sixth-grade classes taught by the same teacher, in six lessons that constituted a…

  12. Sixth Annual Conference on Computers, Freedom, and Privacy: The RealAudio Proceedings.

    ERIC Educational Resources Information Center

    Glover, Barbara; Meernik, Mary

    1996-01-01

    Reviews the sixth Conference on Computers, Freedom, and Privacy (CFP) held in March 1996. Highlights include the Communications Decency Act, part of the 1996 Telecommunications Reform Act; European views; Internet service providers; limiting online speech on campus; cryptography; the global information infrastructure; copyright; and China and the…

  13. Encouraging Sixth-Grade Students' Problem-Solving Performance by Teaching through Problem Solving

    ERIC Educational Resources Information Center

    Bostic, Jonathan D.; Pape, Stephen J.; Jacobbe, Tim

    2016-01-01

    This teaching experiment provided students with continuous engagement in a problem-solving based instructional approach during one mathematics unit. Three sections of sixth-grade mathematics were sampled from a school in Florida, U.S.A. and one section was randomly assigned to experience teaching through problem solving. Students' problem-solving…

  14. Developmental Growth Trajectories in Understanding of Fraction Magnitude from Fourth through Sixth Grade

    ERIC Educational Resources Information Center

    Resnick, Ilyse; Jordan, Nancy C.; Hansen, Nicole; Rajan, Vinaya; Rodrigues, Jessica; Siegler, Robert S.; Fuchs, Lynn S.

    2016-01-01

    Development of fraction number line estimation was assessed longitudinally over five time points between fourth and sixth grades. Although students showed positive linear growth overall, latent class growth analyses revealed three distinct growth trajectory classes: Students who were highly accurate from the start and became even more accurate (n…

  15. Promoting Sixth Graders' Number Sense and Learning Attitudes via Technology-Based Environment

    ERIC Educational Resources Information Center

    Yang, Der Ching; Tsai, Yi Fang

    2010-01-01

    A quasi-experimental design was adopted to investigate the effect of integrating technology into mathematics teaching on students' number sense and their learning attitudes. Two sixth-grade classes were selected from an elementary school in Taiwan for participation in this study. The control group with 32 students followed their usual mathematics…

  16. A Multi-Sensory Approach to Teaching Poetry to Sixth Grade Students.

    ERIC Educational Resources Information Center

    Huettenmueller, Elizabeth Renee

    This study investigated the influence of two approaches to teaching poetry, an aural-visual discussion program and an aural discussion program, on the understanding of and attitudes toward poetry among sixth grade students. The schools, teachers, and 10 classrooms (divided into 20 experimental treatment groups and 5 control groups) were selected…

  17. Indian River County Environmental Education Instructional Guide. Language Arts and Social Studies, Sixth Grade.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee.

    The guide is one in a series for teachers, students, and community members to help them utilize community resources in developing and teaching environmental concepts, responsibility, and problem solving. This particular guide focuses on social studies and language arts aspects of environmental education for sixth graders. Background information…

  18. 76 FR 16470 - Sixth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... Federal Aviation Administration Sixth Meeting: RTCA Special Committee 224: Airport Security Access Control... meeting: Airport Security Access Control Systems (Update to DO-230B). SUMMARY: The FAA is issuing this notice to advise the public of a meeting of RTCA Special Committee 224: Airport Security Access...

  19. The Responses of Fourth, Fifth, and Sixth Grade Black Urban Children to Selected Stories.

    ERIC Educational Resources Information Center

    Howard, Mary Virginia Brown

    The purpose of this investigation was to analyze the preferences of fourth, fifth, and sixth grade urban black children with regard to characters, type of setting and story in books and the relationship between these preferences and grade level, sex, and socioeconomic status. Three hundred seven black students were read to from 15 books of five…

  20. Independent Reading in the Sixth Grade: Free Choice and Access to Material.

    ERIC Educational Resources Information Center

    Coy-Shaffer, Joye; Pettit, Shirley

    A study conducted in the Orange County Public Schools in central Florida investigated the reading interests of sixth-grade students. The study also gathered information from teachers regarding the nature and source of reading materials used for independent reading in their classrooms and on the implementation of sustained silent reading practices.…

  1. Relationships between gifted selection criteria and performance in sixth-grade gifted science

    NASA Astrophysics Data System (ADS)

    Miller, Roxanne Greitz

    This study examined the relationships between gifted selection criteria used in the Dade County Public Schools of Miami, Florida and performance in sixth grade gifted science classes. The goal of the study was to identify significant predictors of performance in sixth grade gifted science classes. Group comparisons of performance were also made. Performance in sixth grade gifted science was defined as the numeric average of nine weeks' grades earned in sixth grade gifted science classes. The sample consisted of 100 subjects who were formerly enrolled in sixth grade gifted science classes over two years at a large, multiethnic public middle school in Dade County. The predictors analyzed were I.Q. score (all scales combined), full scale I.Q. score, verbal scale I.Q. score, performance scale I.Q. score, combined Stanford Achievement Test (SAT) score (Reading Comprehension plus Math Applications), SAT Reading Comprehension score, and SAT Math Applications score. Combined SAT score and SAT Math Applications score were significantly positively correlated to performance in sixth grade gifted science. Performance scale I.Q. score was significantly negatively correlated to performance in sixth grade gifted science. The other predictors examined were not significantly correlated to performance. Group comparison results showed the mean average of nine weeks grades for the full scale I.Q. group was greater than the verbal and performance scale I.Q. groups. Females outperformed males to a highly significant level. Mean g.p.a. for ethnic groups was greatest for Asian students, followed by white non-Hispanic, Hispanic, and black. Students not receiving a lunch subsidy outperformed those receiving subsidies. Comparisons of performance based on gifted qualification plan showed the mean g.p.a. for traditional plan and Plan B groups were not different. Mean g.p.a. for students who qualified for gifted using automatic Math Applications criteria was highest, followed by automatic

  2. Effects of LEGO Mindstorms on convergent and divergent problem-solving and spatial abilities in fifth and sixth grade students

    NASA Astrophysics Data System (ADS)

    Gibbon, Lance W.

    In this quasi-experimental study, 142 fifth and sixth grade students at a suburban elementary school in Northwest Washington State participated in a week-long, 10-hour project using the LEGO Mindstorms Robotics Invention System (RIS). Partners constructed and programmed one robot from visually-based LEGO instructions and a second of their own creation and then shared them at a culminating event. The study is built upon on the constructionist philosophy of Seymour Papert (1980; 1990; 1993; 1999) and an investigation of problem-solving and LEGO robotics by Debra and David Palumbo (1993). A modified switching-replications design provided 3 complete replications within the study and allowed all participants to receive the treatment. Pre and posttests were given. Convergent problem-solving and spatial ability were measured by the Ravens Progressive Matrices (RPM) and divergent problem-solving ability was measured by the Fluency and Flexibility Measure (FFM). The FFM was constructed by the researcher. The development process, piloting, and implementation of this instrument are reported. Overall, Mindstorms did not have a significant effect on convergent problem-solving and spatial reasoning as measured by the RPM. However, infrequent LEGO's users made greater gains on the RPM during the treatment than frequent users, but frequent LEGO users made notable gains during the comparison condition. The multiplicative interaction effect of Testing, Group, and LEGO Use across replications on the RPM is significant, p<.001 ( p=.264 x p=.620 x p=.001). The FFM provides two scores: Fluency, or the number of responses, and Flexibility, or the number of categories into which those responses fit. The findings for Fluency were strong in two replications, p<.005, and frequent LEGO users scored higher than the comparison group on Fluency for all three replications (p=.384, p=.035, p=.090). There was no clear pattern of gender differences on the RPM or FFM. This study provides tentative

  3. Modelling in Primary School: Constructing Conceptual Models and Making Sense of Fractions

    ERIC Educational Resources Information Center

    Shahbari, Juhaina Awawdeh; Peled, Irit

    2017-01-01

    This article describes sixth-grade students' engagement in two model-eliciting activities offering students the opportunity to construct mathematical models. The findings show that students utilized their knowledge of fractions including conceptual and procedural knowledge in constructing mathematical models for the given situations. Some students…

  4. Fuel Cell Handbook, Fifth Edition

    SciTech Connect

    Energy and Environmental Solutions

    2000-10-31

    Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed

  5. Computational and molecular tools for scalable rAAV-mediated genome editing

    PubMed Central

    Stoimenov, Ivaylo; Ali, Muhammad Akhtar; Pandzic, Tatjana; Sjöblom, Tobias

    2015-01-01

    The rapid discovery of potential driver mutations through large-scale mutational analyses of human cancers generates a need to characterize their cellular phenotypes. Among the techniques for genome editing, recombinant adeno-associated virus (rAAV)-mediated gene targeting is suited for knock-in of single nucleotide substitutions and to a lesser degree for gene knock-outs. However, the generation of gene targeting constructs and the targeting process is time-consuming and labor-intense. To facilitate rAAV-mediated gene targeting, we developed the first software and complementary automation-friendly vector tools to generate optimized targeting constructs for editing human protein encoding genes. By computational approaches, rAAV constructs for editing ∼71% of bases in protein-coding exons were designed. Similarly, ∼81% of genes were predicted to be targetable by rAAV-mediated knock-out. A Gateway-based cloning system for facile generation of rAAV constructs suitable for robotic automation was developed and used in successful generation of targeting constructs. Together, these tools enable automated rAAV targeting construct design, generation as well as enrichment and expansion of targeted cells with desired integrations. PMID:25488813

  6. Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing.

    PubMed

    Mout, Rubul; Ray, Moumita; Yesilbag Tonga, Gulen; Lee, Yi-Wei; Tay, Tristan; Sasaki, Kanae; Rotello, Vincent M

    2017-03-28

    Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP) reduces unwanted gene targeting and avoids integrational mutagenesis that can occur through gene delivery strategies. Direct and efficient delivery of Cas9-RNP into the cytosol followed by translocation to the nucleus remains a challenge. Here, we report a remarkably highly efficient (∼90%) direct cytoplasmic/nuclear delivery of Cas9 protein complexed with a guide RNA (sgRNA) through the coengineering of Cas9 protein and carrier nanoparticles. This construct provides effective (∼30%) gene editing efficiency and opens up opportunities in studying genome dynamics.

  7. Generation of Stable Knockout Mammalian Cells by TALEN-Mediated Locus-Specific Gene Editing.

    PubMed

    Mahata, Barun; Biswas, Kaushik

    2017-01-01

    Precise and targeted genome editing using Transcription Activator-Like Effector Endonucleases (TALENs) has been widely used and proven to be an extremely effective and specific knockout strategy in both cultured cells and animal models. The current chapter describes a protocol for the construction and generation of TALENs using serial and hierarchical digestion and ligation steps, and using the synthesized TALEN pairs to achieve locus-specific targeted gene editing in mammalian cell lines using a modified clonal selection strategy in an easy and cost-efficient manner.

  8. RBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction

    PubMed Central

    Miller, Melissa M.; Halbig, Kari; Cruz-Reyes, Jorge; Read, Laurie K.

    2006-01-01

    RBP16 is an abundant RNA binding protein from Trypanosoma brucei mitochondria that affects both RNA editing and stability. We report here experiments aimed at elucidating the mechanism of RBP16 function in RNA editing. In in vitro RNA editing assays, recombinant RBP16 is able to significantly stimulate insertion editing of both CYb and A6 pre-mRNAs. Enhancement of in vitro editing activity occurs at, or prior to, the step of pre-mRNA cleavage, as evidenced by increased accumulation of pre-mRNA 3′ cleavage products in the presence of RBP16. Mutated RBP16 that is severely compromised in cold shock domain (CSD)-mediated RNA binding was able to enhance editing to levels comparable to the wild-type protein in some assays at the highest RBP16 levels tested. However, at low RBP16 concentrations or in assays with native, oligo(U)-tail-bearing gRNAs, editing stimulation by mutant RBP16 was somewhat compromised. Together, these results indicate that both the N-terminal CSD and C-terminal RGG RNA binding domains of RBP16 are required for maximal editing stimulation. Finally, the relaxed specificity of RBP16 for stimulation of both CYb and A6 editing in vitro implicates additional specificity factors that account for the strict CYb specificity of RBP16 action in editing in vivo. Our results constitute the first report of any putative RNA editing accessory factor eliciting an effect on editing in vitro. Overall, these results support a novel accessory role for RBP16 in U insertion editing. PMID:16691000

  9. RBP16 stimulates trypanosome RNA editing in vitro at an early step in the editing reaction.

    PubMed

    Miller, Melissa M; Halbig, Kari; Cruz-Reyes, Jorge; Read, Laurie K

    2006-07-01

    RBP16 is an abundant RNA binding protein from Trypanosoma brucei mitochondria that affects both RNA editing and stability. We report here experiments aimed at elucidating the mechanism of RBP16 function in RNA editing. In in vitro RNA editing assays, recombinant RBP16 is able to significantly stimulate insertion editing of both CYb and A6 pre-mRNAs. Enhancement of in vitro editing activity occurs at, or prior to, the step of pre-mRNA cleavage, as evidenced by increased accumulation of pre-mRNA 3' cleavage products in the presence of RBP16. Mutated RBP16 that is severely compromised in cold shock domain (CSD)-mediated RNA binding was able to enhance editing to levels comparable to the wild-type protein in some assays at the highest RBP16 levels tested. However, at low RBP16 concentrations or in assays with native, oligo(U)-tail-bearing gRNAs, editing stimulation by mutant RBP16 was somewhat compromised. Together, these results indicate that both the N-terminal CSD and C-terminal RGG RNA binding domains of RBP16 are required for maximal editing stimulation. Finally, the relaxed specificity of RBP16 for stimulation of both CYb and A6 editing in vitro implicates additional specificity factors that account for the strict CYb specificity of RBP16 action in editing in vivo. Our results constitute the first report of any putative RNA editing accessory factor eliciting an effect on editing in vitro. Overall, these results support a novel accessory role for RBP16 in U insertion editing.

  10. Changing genetic information through RNA editing

    NASA Technical Reports Server (NTRS)

    Maas, S.; Rich, A.

    2000-01-01

    RNA editing, the post-transcriptional alteration of a gene-encoded sequence, is a widespread phenomenon in eukaryotes. As a consequence of RNA editing, functionally distinct proteins can be produced from a single gene. The molecular mechanisms involved include single or multiple base insertions or deletions as well as base substitutions. In mammals, one type of substitutional RNA editing, characterized by site-specific base-modification, was shown to modulate important physiological processes. The underlying reaction mechanism of substitutional RNA editing involves hydrolytic deamination of cytosine or adenosine bases to uracil or inosine, respectively. Protein factors have been characterized that are able to induce RNA editing in vitro. A supergene family of RNA-dependent deaminases has emerged with the recent addition of adenosine deaminases specific for tRNA. Here we review the developments that have substantially increased our understanding of base-modification RNA editing over the past few years, with an emphasis on mechanistic differences, evolutionary aspects and the first insights into the regulation of editing activity.

  11. Gateways to Readable Books. Fifth Edition.

    ERIC Educational Resources Information Center

    Withrow, Dorothy E.; And Others

    This bibliography of more than 1,000 titles for retarded and reluctant adolescent readers notes the grade level of difficulty of each book (the majority are of fifth-grade and sixth-grade level of difficulty) and includes annotations to indicate the nature of the books and to arouse interest in them. The categories under which the books are listed…

  12. NRP 7th Edition: Are You Prepared?

    PubMed

    Zaichkin, Jeanette; Mccarney, Linda; Weiner, Gary

    2016-01-01

    The seventh edition of the American Academy of Pediatrics/American Heart Association Neonatal Resuscitation Program (NRP) materials must be in use by January 1, 2017. As in previous editions, changes in resuscitation science are based on an international review and consensus of current resuscitation science. The seventh edition NRP materials also include enhancements to training materials aimed at improving the quality of NRP instruction and providing the opportunity for ongoing education. A standardized approach to instructor training, an online Instructor Toolkit, eSim cases, and a new learning management system are among the new resources.

  13. Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-to-inosine RNA editing.

    PubMed

    Fukuda, Masatora; Kurihara, Kei; Yamaguchi, Shota; Oyama, Yui; Deshimaru, Masanobu

    2014-03-01

    Adenosine-to-inosine (A-to-I) RNA editing is an endogenous regulatory mechanism involved in various biological processes. Site-specific, editing-state-dependent degradation of target RNA may be a powerful tool both for analyzing the mechanism of RNA editing and for regulating biological processes. Previously, we designed an artificial hammerhead ribozyme (HHR) for selective, site-specific RNA cleavage dependent on the A-to-I RNA editing state. In the present work, we developed an improved strategy for constructing a trans-acting HHR that specifically cleaves target editing sites in the adenosine but not the inosine state. Specificity for unedited sites was achieved by utilizing a sequence encoding the intrinsic cleavage specificity of a natural HHR. We used in vitro selection methods in an HHR library to select for an extended HHR containing a tertiary stabilization motif that facilitates HHR folding into an active conformation. By using this method, we successfully constructed highly active HHRs with unedited-specific cleavage. Moreover, using HHR cleavage followed by direct sequencing, we demonstrated that this ribozyme could cleave serotonin 2C receptor (HTR2C) mRNA extracted from mouse brain, depending on the site-specific editing state. This unedited-specific cleavage also enabled us to analyze the effect of editing state at the E and C sites on editing at other sites by using direct sequencing for the simultaneous quantification of the editing ratio at multiple sites. Our approach has the potential to elucidate the mechanism underlying the interdependencies of different editing states in substrate RNA with multiple editing sites.

  14. Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-to-inosine RNA editing

    PubMed Central

    Fukuda, Masatora; Kurihara, Kei; Yamaguchi, Shota; Oyama, Yui; Deshimaru, Masanobu

    2014-01-01

    Adenosine-to-inosine (A-to-I) RNA editing is an endogenous regulatory mechanism involved in various biological processes. Site-specific, editing-state–dependent degradation of target RNA may be a powerful tool both for analyzing the mechanism of RNA editing and for regulating biological processes. Previously, we designed an artificial hammerhead ribozyme (HHR) for selective, site-specific RNA cleavage dependent on the A-to-I RNA editing state. In the present work, we developed an improved strategy for constructing a trans-acting HHR that specifically cleaves target editing sites in the adenosine but not the inosine state. Specificity for unedited sites was achieved by utilizing a sequence encoding the intrinsic cleavage specificity of a natural HHR. We used in vitro selection methods in an HHR library to select for an extended HHR containing a tertiary stabilization motif that facilitates HHR folding into an active conformation. By using this method, we successfully constructed highly active HHRs with unedited-specific cleavage. Moreover, using HHR cleavage followed by direct sequencing, we demonstrated that this ribozyme could cleave serotonin 2C receptor (HTR2C) mRNA extracted from mouse brain, depending on the site-specific editing state. This unedited-specific cleavage also enabled us to analyze the effect of editing state at the E and C sites on editing at other sites by using direct sequencing for the simultaneous quantification of the editing ratio at multiple sites. Our approach has the potential to elucidate the mechanism underlying the interdependencies of different editing states in substrate RNA with multiple editing sites. PMID:24448449

  15. Marketing/Planning Library and Information Services. Second Edition.

    ERIC Educational Resources Information Center

    Weingand, Darlene E.

    In the first edition of this book, the concepts of marketing and planning library and information services were presented as effective managerial strategies. Several paragraphs from the introduction to the first edition are reproduced, with author commentary, in this edition as an affirmation that the message is still true. In this second edition,…

  16. RNA editing generates cellular subsets with diverse sequence within populations

    PubMed Central

    Harjanto, Dewi; Papamarkou, Theodore; Oates, Chris J.; Rayon-Estrada, Violeta; Papavasiliou, F. Nina; Papavasiliou, Anastasia

    2016-01-01

    RNA editing is a mutational mechanism that specifically alters the nucleotide content in transcribed RNA. However, editing rates vary widely, and could result from equivalent editing amongst individual cells, or represent an average of variable editing within a population. Here we present a hierarchical Bayesian model that quantifies the variance of editing rates at specific sites using RNA-seq data from both single cells, and a cognate bulk sample to distinguish between these two possibilities. The model predicts high variance for specific edited sites in murine macrophages and dendritic cells, findings that we validated experimentally by using targeted amplification of specific editable transcripts from single cells. The model also predicts changes in variance in editing rates for specific sites in dendritic cells during the course of LPS stimulation. Our data demonstrate substantial variance in editing signatures amongst single cells, supporting the notion that RNA editing generates diversity within cellular populations. PMID:27418407

  17. Karlsruhe nuclide chart - new 9. edition 2015

    SciTech Connect

    Soti, Zsolt; Magill, Joseph; Pfennig, Gerda; Derher, Raymond

    2015-07-01

    Following the success of the 8. Edition of the Karlsruhe Nuclide Chart 2012, a new edition is planned for 2015. Since the 2012 edition, more than 100 nuclides have been discovered and about 1400 nuclides have been updated. In summary, the new 9. edition contains decay and radiation data on approximately 3230 ground state nuclides and 740 isomers from 118 chemical elements. The accompanying booklet provides a detailed explanation of the nuclide box structure used in the Chart. An expanded section contains many additional nuclide decay schemes to aid the user to interpret the highly condensed information in the nuclide boxes. The booklet contains - in addition to the latest values of the physical constants and physical properties - a periodic table of the elements, tables of new and updated nuclides, and a difference chart showing the main changes in the Chart graphically. (authors)

  18. Research Review: Magazine Editors and Editing Practices.

    ERIC Educational Resources Information Center

    Jolliffe, Lee

    1994-01-01

    Reviews and critiques literature in the subfield of magazine editing research, chiefly biographical studies of individual editors and various types of studies of editorial practices, including surveys, magazine content analyses, and close qualitative examinations of editors' relationships with others. (SR)

  19. America's Children and the Environment, Third Edition ...

    EPA Pesticide Factsheets

    America's Children and the Environment is the U.S. EPA's report of children's environmental health indicators. Two editions of the report have been published, in 2000 and 2003, and a website is maintained with updated values for the indicators. The new Third Edition of America's Children and the Environment incorporates updates and revisions to previous content as well as several new indicators. America's Children and the Environment is the U.S. EPA's report of children's environmental health indicators. Two editions of the report have been published, in 2000 and 2003, and a website is maintained with updated values for the indicators. The new Third Edition of America's Children and the Environment incorporates updates and revisions to previous content as well as several new indicators.

  20. An automatic editing algorithm for GPS data

    NASA Technical Reports Server (NTRS)

    Blewitt, Geoffrey

    1990-01-01

    An algorithm has been developed to edit automatically Global Positioning System data such that outlier deletion, cycle slip identification, and correction are independent of clock instability, selective availability, receiver-satellite kinematics, and tropospheric conditions. This algorithm, called TurboEdit, operates on undifferenced, dual frequency carrier phase data, and requires the use of P code pseudorange data and a smoothly varying ionospheric electron content. TurboEdit was tested on the large data set from the CASA Uno experiment, which contained over 2500 cycle slips.Analyst intervention was required on 1 percent of the station-satellite passes, almost all of these problems being due to difficulties in extrapolating variations in the ionospheric delay. The algorithm is presently being adapted for real time data editing in the Rogue receiver for continuous monitoring applications.

  1. Editing soft shadows in a digital photograph.

    PubMed

    Mohan, Ankit; Tumblin, Jack; Choudhury, Prasun

    2007-01-01

    This technique for modeling, editing, and rendering shadow edges in a photograph or a synthetic image lets users separate the shadow from the rest of the image and make arbitrary adjustments to its position, sharpness, and intensity.

  2. Applications of genome editing by programmable nucleases to the metabolic engineering of secondary metabolites.

    PubMed

    Leitão, Ana Lúcia; Costa, Marina C; Enguita, Francisco J

    2017-01-10

    Genome engineering is a branch of modern biotechnology composed of a cohort of protocols designed to construct and modify a genotype with the main objective of giving rise to a desired phenotype. Conceptually, genome engineering is based on the so called genome editing technologies, a group of genetic techniques that allow either to delete or to insert genetic information in a particular genomic locus. Ten years ago, genome editing tools were limited to virus-driven integration and homologous DNA recombination. However, nowadays the uprising of programmable nucleases is rapidly changing this paradigm. There are two main families of modern tools for genome editing depending on the molecule that controls the specificity of the system and drives the editor machinery to its place of action. Enzymes such as Zn-finger and TALEN nucleases are protein-driven genome editors; while CRISPR system is a nucleic acid-guided editing system. Genome editing techniques are still not widely applied for the design of new compounds with pharmacological activity, but they are starting to be considered as promising tools for rational genome manipulation in biotechnology applications. In this review we will discuss the potential applications of programmable nucleases for the metabolic engineering of secondary metabolites with biological activity.

  3. Editing the UMLS Metathesaurus: Review and Enhancement of a Computed Knowledge Source

    PubMed Central

    Sperzel, David; Erlbaum, Mark; Fuller, Lloyd; Sherertz, David; Olson, Nels; Schuyler, Peri; Hole, William; Savage, Allan; Passarelli, Philip; Tuttle, Mark

    1990-01-01

    This paper describes the editing of Meta-1, the first official version of the National Library of Medicine's (NLM) Unified Medical Language System (UMLS) Metathesaurus. After a preliminary version of Meta-1 was generated by automated techniques, it was edited by domain experts. The goal of editing was to enhance approximately 30,000 Metathesaurus entries and to correct “errors of commission” introduced by the automated techniques. Enhancements were made by assigning semantic types (such as “Disease or Syndrome” or “Virus”) and lexical tags (such as “eponym”) to the Meta-1 entries. The production of Meta-1 required balancing the costs of human and computational resources appropriately, and it may illustrate a paradigm for the construction of large biomedical information resources. The tool-supported process of editing Meta-1, as well as some of the issues that arose during this endeavor, are presented. Despite its large scale, the Meta-1 editing task was accomplished within the specified constraints. The work was completed through the part-time efforts of twenty-six editors and project managers over a one-year period.

  4. Looking forward to genetically edited fruit crops.

    PubMed

    Nagamangala Kanchiswamy, Chidananda; Sargent, Daniel James; Velasco, Riccardo; Maffei, Massimo E; Malnoy, Mickael

    2015-02-01

    The availability of genome sequences for many fruit crops has redefined the boundaries of genetic engineering and genetically modified (GM) crop plants. However commercialization of GM crops is hindered by numerous regulatory and social hurdles. Here, we focus on recently developed genome-editing tools for fruit crop improvement and their importance from the consumer perspective. Challenges and opportunities for the deployment of new genome-editing tools for fruit plants are also discussed.

  5. Proceedings of the sixth international conference on fluidized bed combustion. Volume III. Technical sessions

    SciTech Connect

    1980-08-01

    The Sixth International Conference on Fluidized Bed Combustion was held April 9-11, 1980, at the Atlanta Hilton, Atlanta, Georgia. It was sponsored by the US Department of Energy, the Electric Power Research Institute, the US Environmental Protection Agency, and the Tennessee Valley Authority. Forty-five papers from Vol. III of the proceedings have been entered individually into EDB and ERA. Two papers had been entered previously from other sources. (LTN)

  6. Controlling maternal feeding practices associated with decreased dieting behavior in sixth-grade children.

    PubMed

    Rhee, Kyung E; Appugliese, Danielle P; Prisco, Alicia; Kaciroti, Niko A; Corwyn, Robert F; Bradley, Robert H; Lumeng, Julie C

    2010-04-01

    Controlling maternal feeding practices have been linked to increased caloric intake, disinhibited eating, and obesity in children. Its relationship to child dieting behavior, however, is unknown. Using the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, this study examined whether controlling feeding practices are associated with increased or decreased dieting behavior in children. Controlling maternal feeding practices were assessed in third grade with the question, "Do you let your child eat what he/she feels like eating?" Answers ranged from 1 to 4; higher scores were reverse-coded to indicate greater control. Child dieting behavior was assessed in sixth grade and dichotomized into "any dieting behaviors" vs "none." Multiple logistic regression was used to investigate the relationship between controlling maternal feeding practices and dieting behavior and included the covariates of sex, race, maternal education, maternal weight status, child weight status in third grade, and change in body mass index z score between third and sixth grade. In sixth grade (n=776), 41.5% of children engaged in dieting behavior. In the multivariate analysis, greater maternal control over child eating predicted lower odds of child dieting in sixth grade (odds ratio=0.79; 95% confidence interval: 0.64 to 0.97). There was no interaction between controlling maternal feeding practices and child's sex or baseline obesity status. Exerting more control over what a child eats in third grade may protect against future dieting behavior in children, independent of child's weight status or rate of weight gain. Further work is needed to better define which controlling feeding practices are beneficial for the child.

  7. Cranial Sixth-Nerve Palsy and Eosinophilia in an Outbreak of Mycoplasma Pneumonia

    PubMed Central

    Wing, Howard J.; Lindzon, Martin

    1987-01-01

    The authors discuss a case in which three siblings presented with Mycoplasma pneumonia. All three had a typical rise in complement fixation antibody titres. However, the sibling with the highest titre also developed cranial sixth-nerve palsy; in addition, she was the only one of the three who did not have an eosinophilia. The authors review the symptomatology of Mycoplasma pneumonia and the involvement of the central nervous system. PMID:21263943

  8. CHRONICLE: Sixth International School on Coherent Optics, Ustron, Poland, September 19-26, 1985

    NASA Astrophysics Data System (ADS)

    Novikov, V. D.; Pestov, E. G.

    1986-06-01

    A summary is given of the lectures and papers presented at the Sixth International School on Coherent Optics (Quantum Optics '85), Ustron, Poland, on September 19-26, 1985. Recent progress in theoretical and experimental quantum optics is reported under the headings of quantum statistical properties of optical fields, appearance and properties of chaos in quantum systems, influence of high-power radiation on the relaxation processes, nonlinear and multiphoton processes.

  9. Proceedings of the Sixth International Conference on Fluidized Bed Combustion. Volume 1. Plenary sessions

    SciTech Connect

    1980-08-01

    The Sixth International Conference on Fluidized Bed Combustion was held at the Atlanta Hilton, Atlanta, Georgia, April 9-11, 1980. The papers in this volume involved presentation of the research and development programs of the US (US DOE, TVA, EPRI and US EPA), United Kingdom, Federal Republic of Germany and the People's Republic of China. Eight papers from Vol. 1 (Plenary Sessions) of the proceedings have been entered individually into EDB and ERA. (LTN)

  10. Summaries of the Sixth Annual JPL Airborne Earth Science Workshop. Volume 1; AVIRIS Workshop

    NASA Technical Reports Server (NTRS)

    Green, Robert O. (Editor)

    1996-01-01

    This publication contains the summaries for the Sixth Annual JPL Airborne Earth Science Workshop, held in Pasadena, California, on March 4-8, 1996. The main workshop is divided into two smaller workshops as follows: (1) The Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) workshop, on March 4-6. The summaries for this workshop appear in Volume 1; (2) The Airborne Synthetic Aperture Radar (AIRSAR) workshop, on March 6-8. The summaries for this workshop appear in Volume 2.

  11. Genome editing with engineered nucleases in plants.

    PubMed

    Osakabe, Yuriko; Osakabe, Keishi

    2015-03-01

    Numerous examples of successful 'genome editing' now exist. Genome editing uses engineered nucleases as powerful tools to target specific DNA sequences to edit genes precisely in the genomes of both model and crop plants, as well as a variety of other organisms. The DNA-binding domains of zinc finger (ZF) proteins were the first to be used as genome editing tools, in the form of designed ZF nucleases (ZFNs). More recently, transcription activator-like effector nucleases (TALENs), as well as the clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, which utilizes RNA-DNA interactions, have proved useful. A key step in genome editing is the generation of a double-stranded DNA break that is specific to the target gene. This is achieved by custom-designed endonucleases, which enable site-directed mutagenesis via a non-homologous end-joining (NHEJ) repair pathway and/or gene targeting via homologous recombination (HR) to occur efficiently at specific sites in the genome. This review provides an overview of recent advances in genome editing technologies in plants, and discusses how these can provide insights into current plant molecular biology research and molecular breeding technology.

  12. Precise genome editing by homologous recombination

    PubMed Central

    Hoshijima, K.; Jurynec, M.J.; Grunwald, D.J.

    2016-01-01

    Simple and efficient methods are presented for creating precise modifications of the zebrafish genome. Edited alleles are generated by homologous recombination between the host genome and double-stranded DNA (dsDNA) donor molecules, stimulated by the induction of double-strand breaks at targeted loci in the host genome. Because several kilobase-long tracts of sequence can be exchanged, multiple genome modifications can be generated simultaneously at a single locus. Methods are described for creating: (1) alleles with simple sequence changes or in-frame additions, (2) knockin/knockout alleles that express a reporter protein from an endogenous locus, and (3) conditional alleles in which exons are flanked by recombinogenic loxP sites. Significantly, our approach to genome editing allows the incorporation of a linked reporter gene into the donor sequences so that successfully edited alleles can be identified by virtue of expression of the reporter. Factors affecting the efficiency of genome editing are discussed, including the finding that dsDNA products of I-SceI meganuclease enzyme digestion are particularly effective as donor molecules for gene-editing events. Reagents and procedures are described for accomplishing efficient genome editing in the zebrafish. PMID:27443923

  13. Approximate Graph Edit Distance in Quadratic Time.

    PubMed

    Riesen, Kaspar; Ferrer, Miquel; Bunke, Horst

    2015-09-14

    Graph edit distance is one of the most flexible and general graph matching models available. The major drawback of graph edit distance, however, is its computational complexity that restricts its applicability to graphs of rather small size. Recently the authors of the present paper introduced a general approximation framework for the graph edit distance problem. The basic idea of this specific algorithm is to first compute an optimal assignment of independent local graph structures (including substitutions, deletions, and insertions of nodes and edges). This optimal assignment is complete and consistent with respect to the involved nodes of both graphs and can thus be used to instantly derive an admissible (yet suboptimal) solution for the original graph edit distance problem in O(n3) time. For large scale graphs or graph sets, however, the cubic time complexity may still be too high. Therefore, we propose to use suboptimal algorithms with quadratic rather than cubic time for solving the basic assignment problem. In particular, the present paper introduces five different greedy assignment algorithms in the context of graph edit distance approximation. In an experimental evaluation we show that these methods have great potential for further speeding up the computation of graph edit distance while the approximated distances remain sufficiently accurate for graph based pattern classification.

  14. Genome editing systems in novel therapies.

    PubMed

    Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui

    2016-01-01

    Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in human cells, however, had prevented its clinical application until the recent advancements in designer endonuclease technologies. The significantly improved genome editing efficiencies aided by ZFN, TALEN, and CRISPR systems provide unprecedented opportunities not only for biomedical research, but also for developing novel therapies. Applications based on these genome editing tools to disrupt deleterious genes, correct genetic mutations, deliver functional transgenes more effectively or even modify the epigenetic landscape are being actively investigated for gene and cell therapy purposes. Encouraging results have been obtained in limited clinical trials in the past two years. While most of the applications are still in proof-of-principle or preclinical development stages, it is anticipated that the coming years will see increasing clinical success in novel therapies based on the modern genome editing technologies. It should be noted that critical issues still remain before the technologies can be translated into more reliable therapies. These key issues include off-target evaluation, establishing appropriate preclinical models and improving the currently low efficiency of homology-based precise gene replacement. In this review we discuss the preclinical and clinical studies aiming at translating the genome editing technologies as well as the issues that are important for more successful translation.

  15. Precise genome editing by homologous recombination.

    PubMed

    Hoshijima, K; Jurynec, M J; Grunwald, D J

    2016-01-01

    Simple and efficient methods are presented for creating precise modifications of the zebrafish genome. Edited alleles are generated by homologous recombination between the host genome and double-stranded DNA (dsDNA) donor molecules, stimulated by the induction of double-strand breaks at targeted loci in the host genome. Because several kilobase-long tracts of sequence can be exchanged, multiple genome modifications can be generated simultaneously at a single locus. Methods are described for creating: (1) alleles with simple sequence changes or in-frame additions, (2) knockin/knockout alleles that express a reporter protein from an endogenous locus, and (3) conditional alleles in which exons are flanked by recombinogenic loxP sites. Significantly, our approach to genome editing allows the incorporation of a linked reporter gene into the donor sequences so that successfully edited alleles can be identified by virtue of expression of the reporter. Factors affecting the efficiency of genome editing are discussed, including the finding that dsDNA products of I-SceI meganuclease enzyme digestion are particularly effective as donor molecules for gene-editing events. Reagents and procedures are described for accomplishing efficient genome editing in the zebrafish.

  16. The commercialization of genome-editing technologies.

    PubMed

    Brinegar, Katelyn; K Yetisen, Ali; Choi, Sun; Vallillo, Emily; Ruiz-Esparza, Guillermo U; Prabhakar, Anand M; Khademhosseini, Ali; Yun, Seok-Hyun

    2017-01-18

    The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational medicine. In our analyses, we evaluated the patent landscape of gene-editing technologies and found that in comparison to earlier gene-editing techniques, CRISPR has gained significant traction and this has established dominance. Although most of the gene-editing technologies originated from the industry, CRISPR has been pioneered by academic research institutions. The spinout of CRISPR biotechnology companies from academic institutions demonstrates a shift in entrepreneurship strategies that were previously led by the industry. These academic institutions, and their subsequent companies, are competing to generate comprehensive intellectual property portfolios to rapidly commercialize CRISPR products. Our analysis shows that the emergence of CRISPR has resulted in a fivefold increase in genome-editing bioenterprise investment over the last year. This entrepreneurial movement has spurred a global biotechnology revolution in the realization of novel gene-editing technologies. This global shift in bioenterprise will continue to grow as the demand for personalized medicine, genetically modified crops and environmentally sustainable biofuels increases. However, the monopolization of intellectual property, negative public perception of genetic engineering and ambiguous regulatory policies may limit the growth of these market segments.

  17. The effects of collaborative video production on the attitudes and science knowledge of sixth graders

    NASA Astrophysics Data System (ADS)

    Gaston, Joseph Pickett

    This quantitative study examined the effects of collaborative video production (CVP) on the attitudes and conceptual understanding of sixth-grade science students at a public middle school in the Southeastern United States. This study followed the nonequivalent control group design, as described by Campbell and Stanley (1963). The study involved four classes of sixth-grade students. The two control classes were taught the science concept by the cooperating teacher through direct instruction, and the two experimental classes learned the science concept through the CVP project. Pre- and posttests were administered to all students, as well as two pre- and post-surveys measuring student attitudes towards science and technology. Analysis of covariance (ANCOVA) with the pretest scores as the covariate (Xc) was conducted with the posttest and post-survey data to determine if a significant difference existed in scores between the two groups. In each case, no significant difference was found. The results of this study suggest that CVP was as effective at conveying conceptual understanding to sixth-grade science students as direct instruction. Although not significant, the study also showed that mean scores of students' attitudes towards science and technology increased from pre-surveys to post-surveys for those who participated in the CVP activity. These findings suggest that the treatment contributed to an increase in participants' attitudes and towards technology and the academic subject. No such increase in mean post-survey scores existed for students receiving direct instruction.

  18. A High-Coverage Yersinia pestis Genome from a Sixth-Century Justinianic Plague Victim

    PubMed Central

    Feldman, Michal; Harbeck, Michaela; Keller, Marcel; Spyrou, Maria A.; Rott, Andreas; Trautmann, Bernd; Scholz, Holger C.; Päffgen, Bernd; Peters, Joris; McCormick, Michael; Bos, Kirsten; Herbig, Alexander; Krause, Johannes

    2016-01-01

    The Justinianic Plague, which started in the sixth century and lasted to the mid eighth century, is thought to be the first of three historically documented plague pandemics causing massive casualties. Historical accounts and molecular data suggest the bacterium Yersinia pestis as its etiological agent. Here we present a new high-coverage (17.9-fold) Y. pestis genome obtained from a sixth-century skeleton recovered from a southern German burial site close to Munich. The reconstructed genome enabled the detection of 30 unique substitutions as well as structural differences that have not been previously described. We report indels affecting a lacl family transcription regulator gene as well as nonsynonymous substitutions in the nrdE, fadJ, and pcp genes, that have been suggested as plague virulence determinants or have been shown to be upregulated in different models of plague infection. In addition, we identify 19 false positive substitutions in a previously published lower-coverage Y. pestis genome from another archaeological site of the same time period and geographical region that is otherwise genetically identical to the high-coverage genome sequence reported here, suggesting low-genetic diversity of the plague during the sixth century in rural southern Germany. PMID:27578768

  19. Book Review: New Perspectives on Technical Editing

    NASA Astrophysics Data System (ADS)

    Murphy, A. J. (Ed.); Sterken, Christiaan

    2012-08-01

    New Perspectives on Technical Editing by Avon J. Murphy (ed.) ISBN : 978-0895033949 (2010) Baywood Publishing Company Inc, Hardcover, 210 pages, 35.5 GBP This book presents a collection of 10 chapters dealing with diverse aspects of technical editing (ie, editorial planning, and analysis and structural changes made to other people's technological documents): research in technical editing, trends and teaching of technical editing, copyediting, and technical journal editing. The role and function of the modern journal and book editor is also dealt with in detail. Each chapter is written by an expert in the field: senior editors, university professors in technical communication, technical writers and linguists. The ever-evolving role of the editor is clearly elucidated in several historical reviews, and in the descriptions of the expectations for the future. A very striking aspect of this book is its extensive collection of bibliographic resources: every chapter lists dozens of very useful references, and the closing chapter, and annotated bibliography, contain many not so well known references, and are most useful. All in all, the book is a treasure trove listing more than 400 references, in addition to numerous webpage URLs embedded in the texts. The book is designed to help the reader to understand current practices and norms in technical editing, and to help to take action in editing as well as in teaching and educating would-be editors. The audience for this book thus includes editors and teachers, but also writers, researchers and students. A deep reading of this book will result in a better understanding of the difference between full technical editing and its much narrower component so well known as copyediting, and will convince any prospective editor that editing should not be undertaken if the people involved do not master the art of precision and accuracy in technical (as well as in human) communication, do not possess the technical know how and computer

  20. Cas9-mediated genome editing in the methanogenic archaeon Methanosarcina acetivorans.

    PubMed

    Nayak, Dipti D; Metcalf, William W

    2017-03-14

    Although Cas9-mediated genome editing has proven to be a powerful genetic tool in eukaryotes, its application in Bacteria has been limited because of inefficient targeting or repair; and its application to Archaea has yet to be reported. Here we describe the development of a Cas9-mediated genome-editing tool that allows facile genetic manipulation of the slow-growing methanogenic archaeon Methanosarcina acetivorans Introduction of both insertions and deletions by homology-directed repair was remarkably efficient and precise, occurring at a frequency of approximately 20% relative to the transformation efficiency, with the desired mutation being found in essentially all transformants examined. Off-target activity was not observed. We also observed that multiple single-guide RNAs could be expressed in the same transcript, reducing the size of mutagenic plasmids and simultaneously simplifying their design. Cas9-mediated genome editing reduces the time needed to construct mutants by more than half (3 vs. 8 wk) and allows simultaneous construction of double mutants with high efficiency, exponentially decreasing the time needed for complex strain constructions. Furthermore, coexpression the nonhomologous end-joining (NHEJ) machinery from the closely related archaeon, Methanocella paludicola, allowed efficient Cas9-mediated genome editing without the need for a repair template. The NHEJ-dependent mutations included deletions ranging from 75 to 2.7 kb in length, most of which appear to have occurred at regions of naturally occurring microhomology. The combination of homology-directed repair-dependent and NHEJ-dependent genome-editing tools comprises a powerful genetic system that enables facile insertion and deletion of genes, rational modification of gene expression, and testing of gene essentiality.

  1. Microinjection for transgenesis and genome editing in threespine sticklebacks

    PubMed Central

    Erickson, Priscilla A.; Ellis, Nicholas A.

    2017-01-01

    SHORT ABSTRACT Transgenic manipulations and genome editing are critical for functionally testing the roles of genes and cis-regulatory elements. Here a detailed microinjection protocol for the generation of genomic modifications (including Tol2-mediated fluorescent reporter transgene constructs, TALENs, and CRISPRs) is presented for the emergent model fish, the threespine stickleback. LONG ABSTRACT The threespine stickleback fish has emerged as a powerful system to study the genetic basis of a wide variety of morphological, physiological, and behavioral phenotypes. The remarkably diverse phenotypes that have evolved as marine populations adapt to countless freshwater environments, combined with the ability to cross marine and freshwater forms, provide a rare vertebrate system in which genetics can be used to map genomic regions controlling evolved traits. Excellent genomic resources are now available, facilitating molecular genetic dissection of evolved changes. While mapping experiments generate lists of interesting candidate genes, functional genetic manipulations are required to test the roles of these genes. Gene regulation can be studied with transgenic reporter plasmids and BACs integrated into the genome using the Tol2 transposase. Functions of specific candidate genes and cis-regulatory elements can be assessed by inducing targeted mutations with TALEN and CRISPR/Cas9 genome editing reagents. All methods require introducing nucleic acids into fertilized one-cell stickleback embryos, a task made challenging by the thick chorion of stickleback embryos and the relatively small and thin blastomere. Here, a detailed protocol for microinjection of nucleic acids into stickleback embryos is described for transgenic and genome editing applications to study gene expression and function, as well as techniques to assess the success of transgenesis and recover stable lines. PMID:27214565

  2. Residential Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook.

    ERIC Educational Resources Information Center

    Taylor, Mark

    Residential Wiring, the second publication in a series of three wiring publications, prepares students for entry-level employment in the residential wiring trade. Instructional materials include a teacher edition, student guide, and student workbook. The teacher edition begins with introductory pages, including a training and competency profile,…

  3. Learn Sparse Dictionaries for Edit Propagation.

    PubMed

    Xiaowu Chen; Jianwei Li; Dongqing Zou; Qinping Zhao

    2016-04-01

    With the increasing availability of high-resolution images, videos, and 3D models, the demand for scalable large data processing techniques increases. We introduce a method of sparse dictionary learning for edit propagation of large input data. Previous approaches for edit propagation typically employ a global optimization over the whole set of pixels (or vertexes), incurring a prohibitively high memory and time-consumption for large input data. Rather than propagating an edit pixel by pixel, we follow the principle of sparse representation to obtain a representative and compact dictionary and perform edit propagation on the dictionary instead. The sparse dictionary provides an intrinsic basis for input data, and the coding coefficients capture the linear relationship between all pixels and the dictionary atoms. The learned dictionary is then optimized by a novel scheme, which maximizes the Kullback-Leibler divergence between each atom pair to remove redundant atoms. To enable local edit propagation for images or videos with similar appearance, a dictionary learning strategy is proposed by considering range constraint to better account for the global distribution of pixels in their feature space. We show several applications of the sparsity-based edit propagation, including video recoloring, theme editing, and seamless cloning, operating on both color and texture features. Our approach can also be applied to computer graphics tasks, such as 3D surface deformation. We demonstrate that with an atom-to-pixel ratio in the order of 0.01% signifying a significant reduction on memory consumption, our method still maintains a high degree of visual fidelity.

  4. Behavior and finite-size effects of the sixth order cumulant in the three-dimensional Ising universality class

    NASA Astrophysics Data System (ADS)

    Pan, Xue; Chen, Li-Zhu; Wu, Yuan-Fang

    2016-09-01

    The high-order cumulants of conserved charges are suggested to be sensitive observables to search for the critical point of Quantum Chromodynamics (QCD). This has been calculated to the sixth order in experiments. Corresponding theoretical studies on the sixth order cumulant are necessary. Based on the universality of the critical behavior, we study the temperature dependence of the sixth order cumulant of the order parameter using the parametric representation of the three-dimensional Ising model, which is expected to be in the same universality class as QCD. The density plot of the sign of the sixth order cumulant is shown on the temperature and external magnetic field plane. We found that at non-zero external magnetic field, when the critical point is approached from the crossover side, the sixth order cumulant has a negative valley. The width of the negative valley narrows with decreasing external field. Qualitatively, the trend is similar to the result of Monte Carlo simulation on a finite-size system. Quantitatively, the temperature of the sign change is different. Through Monte Carlo simulation of the Ising model, we calculated the sixth order cumulant of different sizes of systems. We discuss the finite-size effects on the temperature at which the cumulant changes sign. Supported by Fund Project of Sichuan Provincial Department of Education (16ZB0339), Fund Project of Chengdu Technological University for Doctor (2016RC004), Major State Basic Research Development Program of China (2014CB845402) and National Natural Science Foundation of China (11405088, 11221504)

  5. FLASH assembly of TALENs for high-throughput genome editing.

    PubMed

    Reyon, Deepak; Tsai, Shengdar Q; Khayter, Cyd; Foden, Jennifer A; Sander, Jeffry D; Joung, J Keith

    2012-05-01

    Engineered transcription activator–like effector nucleases (TALENs) have shown promise as facile and broadly applicable genome editing tools. However, no publicly available high-throughput method for constructing TALENs has been published, and large-scale assessments of the success rate and targeting range of the technology remain lacking. Here we describe the fast ligation-based automatable solid-phase high-throughput (FLASH) system, a rapid and cost-effective method for large-scale assembly of TALENs. We tested 48 FLASH-assembled TALEN pairs in a human cell–based EGFP reporter system and found that all 48 possessed efficient gene-modification activities. We also used FLASH to assemble TALENs for 96 endogenous human genes implicated in cancer and/or epigenetic regulation and found that 84 pairs were able to efficiently introduce targeted alterations. Our results establish the robustness of TALEN technology and demonstrate that FLASH facilitates high-throughput genome editing at a scale not currently possible with other genome modification technologies.

  6. Designed nucleases for targeted genome editing.

    PubMed

    Lee, Junwon; Chung, Jae-Hee; Kim, Ho Min; Kim, Dong-Wook; Kim, Hyongbum

    2016-02-01

    Targeted genome-editing technology using designed nucleases has been evolving rapidly, and its applications are widely expanding in research, medicine and biotechnology. Using this genome-modifying technology, researchers can precisely and efficiently insert, remove or change specific sequences in various cultured cells, micro-organisms, animals and plants. This genome editing is based on the generation of double-strand breaks (DSBs), repair of which modifies the genome through nonhomologous end-joining (NHEJ) or homology-directed repair (HDR). In addition, designed nickase-induced generation of single-strand breaks can also lead to precise genome editing through HDR, albeit at relatively lower efficiencies than that induced by nucleases. Three kinds of designed nucleases have been used for targeted DSB formation: zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system. A growing number of researchers are using genome-editing technologies, which have become more accessible and affordable since the discovery and adaptation of CRISPR-Cas9. Here, the repair mechanism and outcomes of DSBs are reviewed and the three types of designed nucleases are discussed with the hope that such understanding will facilitate applications to genome editing.

  7. WITHDRAWN: Kee, J, Hayes E. and McCuistion L (2009) Pharmacology: A Nursing Process Approach, Sixth Edition (and accompanying study guide), Saunders Elsevier, St. Louis.

    PubMed

    Keogh, Brian

    2009-08-22

    The Publisher regrets that this article is an accidental duplication of a Book Review that has already been published, doi: 10.1016/j.nepr.2009.07.002. The duplicate article has therefore been withdrawn.

  8. Recruiting Trends 1996-97. A National Study of Job Market Trends for New College Graduates among 508 Businesses, Industries, and Governmental Agencies. Twenty-Sixth Edition.

    ERIC Educational Resources Information Center

    Scheetz, L. Patrick

    This study examined recruiting trends of business, industry, and government among new college graduates. Questionnaires were mailed to 4,890 employers, of which 489 returned complete responses. The survey found that new college graduates of 1996-97 can expect growth in job opportunities. An increase of 6.2 percent in job prospects and an increase…

  9. Parents Can Be the Key: A Handbook on Rights and Responsibilities in Special Education for Parents of Children with Disabilities. Sixth Edition.

    ERIC Educational Resources Information Center

    PACER Center, Inc., Minneapolis, MN.

    This booklet for Minnesota parents of children with disabilities provides an overview of special education services. Information is provided on: (1) the purpose of special education; (2) disabilities that are covered under the Individuals with Disabilities Education Act; (3) eligibility age; (4) types of special education and related services; (5)…

  10. BOOK REVIEW: Quantum Gravity: third edition Quantum Gravity: third edition

    NASA Astrophysics Data System (ADS)

    Rovelli, Carlo

    2012-09-01

    The request by Classical and Quantum Gravity to review the third edition of Claus Kiefer's 'Quantum Gravity' puts me in a slightly awkward position. This is a remarkably good book, which every person working in quantum gravity should have on the shelf. But in my opinion quantum gravity has undergone some dramatic advances in the last few years, of which the book makes no mention. Perhaps the omission only attests to the current vitality of the field, where progress is happening fast, but it is strange for me to review a thoughtful, knowledgeable and comprehensive book on my own field of research, which ignores what I myself consider the most interesting results to date. Kiefer's book is unique as a broad introduction and a reliable overview of quantum gravity. There are numerous books in the field which (often notwithstanding titles) focus on a single approach. There are also countless conference proceedings and article collections aiming to be encyclopaedic, but offering disorganized patchworks. Kiefer's book is a careful and thoughtful presentation of all aspects of the immense problem of quantum gravity. Kiefer is very learned, and brings together three rare qualities: he is pedagogical, he is capable of simplifying matter to the bones and capturing the essential, and he offers a serious and balanced evaluation of views and ideas. In a fractured field based on a major problem that does not yet have a solution, these qualities are precious. I recommend Kiefer's book to my students entering the field: to work in quantum gravity one needs a vast amount of technical knowledge as well as a grasp of different ideas, and Kiefer's book offers this with remarkable clarity. This novel third edition simplifies and improves the presentation of several topics, but also adds very valuable new material on quantum gravity phenomenology, loop quantum cosmology, asymptotic safety, Horava-Lifshitz gravity, analogue gravity, the holographic principle, and more. This is a testament

  11. Constructed Wetlands

    EPA Pesticide Factsheets

    these systems can improve water quality, engineers and scientists construct systems that replicate the functions of natural wetlands. Constructed wetlands are treatment systems that use natural processes

  12. Nucleotide specificity of the RNA editing reaction in pea chloroplasts.

    PubMed

    Nakajima, Yuki; Mulligan, R Michael

    2005-12-01

    A sensitive in vitro editing assay for the pea chloroplast petB editing site has been developed and utilized to study the mechanism of C-to-U editing in chloroplast extracts. The in vitro editing assay was characterized by several criteria including: linearity with extract amount; linearity over time; dependence on assay components; and specificity of editing site conversion. The increase in the extent C-to-U conversion of the petB editing site was nearly linear with the amount chloroplast protein extract added, although the reaction appeared to decline in rate after approximately 30 min. The assay was tested for the importance of various assay components, and the omission of protease inhibitor and ATP was shown to dramatically reduce the extent of the editing reaction. Sequence analysis of cDNA clones obtained after an in vitro editing reaction demonstrated that 12 of 17 (71%) clones were edited, and that no other nucleotide changes in these cDNAs were detected. Thus, the fidelity and specificity of the in vitro editing system appears to be excellent, and this system should be suitable to study both mechanism of the editing reaction and editing site selection. The in vitro editing reaction was strongly stimulated by the addition of ATP, and all four NTPs and dNTPs stimulated the editing reaction except for rGTP, which had no effect. Thus, the nucleotide specificity of the editing reaction is broad, and is similar in this respect to the mitochondrial editing system. Most enzyme or processes specifically utilize ATP or GTP for phosphorylation and the ability to substitute other NTPs and dNTPs is unusual. RNA helicases have a similar broad nucleotide specificity and this may reflect the involvement of an RNA helicase in plant organelle editing.

  13. Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system.

    PubMed

    Zhou, Yan; Liu, Yong; Hussmann, Dianna; Brøgger, Peter; Al-Saaidi, Rasha Abdelkadhem; Tan, Shuang; Lin, Lin; Petersen, Trine Skov; Zhou, Guang Qian; Bross, Peter; Aagaard, Lars; Klein, Tino; Rønn, Sif Groth; Pedersen, Henrik Duelund; Bolund, Lars; Nielsen, Anders Lade; Sørensen, Charlotte Brandt; Luo, Yonglun

    2016-07-01

    Programmable DNA nucleases such as TALENs and CRISPR/Cas9 are emerging as powerful tools for genome editing. Dual-fluorescent surrogate systems have been demonstrated by several studies to recapitulate DNA nuclease activity and enrich for genetically edited cells. In this study, we created a single-strand annealing-directed, dual-fluorescent surrogate reporter system, referred to as C-Check. We opted for the Golden Gate Cloning strategy to simplify C-Check construction. To demonstrate the utility of the C-Check system, we used the C-Check in combination with TALENs or CRISPR/Cas9 in different scenarios of gene editing experiments. First, we disrupted the endogenous pIAPP gene (3.0 % efficiency) by C-Check-validated TALENs in primary porcine fibroblasts (PPFs). Next, we achieved gene-editing efficiencies of 9.0-20.3 and 4.9 % when performing single- and double-gene targeting (MAPT and SORL1), respectively, in PPFs using C-Check-validated CRISPR/Cas9 vectors. Third, fluorescent tagging of endogenous genes (MYH6 and COL2A1, up to 10.0 % frequency) was achieved in human fibroblasts with C-Check-validated CRISPR/Cas9 vectors. We further demonstrated that the C-Check system could be applied to enrich for IGF1R null HEK293T cells and CBX5 null MCF-7 cells with frequencies of nearly 100.0 and 86.9 %, respectively. Most importantly, we further showed that the C-Check system is compatible with multiplexing and for studying CRISPR/Cas9 sgRNA specificity. The C-Check system may serve as an alternative dual-fluorescent surrogate tool for measuring DNA nuclease activity and enrichment of gene-edited cells, and may thereby aid in streamlining programmable DNA nuclease-mediated genome editing and biological research.

  14. A Comprehensive Toolbox for Genome Editing in Cultured Drosophila melanogaster Cells.

    PubMed

    Kunzelmann, Stefan; Böttcher, Romy; Schmidts, Ines; Förstemann, Klaus

    2016-06-01

    Custom genome editing has become an essential element of molecular biology. In particular, the generation of fusion constructs with epitope tags or fluorescent proteins at the genomic locus facilitates the analysis of protein expression, localization, and interaction partners at physiologic levels. Following up on our initial publication, we now describe a considerably simplified, more efficient, and readily scalable experimental workflow for PCR-based genome editing in cultured Drosophila melanogaster cells. Our analysis at the act5C locus suggests that PCR-based homology arms of 60 bp are sufficient to reach targeting efficiencies of up to 80% after selection; extension to 80 bp (PCR) or 500 bp (targeting vector) did not further improve the yield. We have expanded our targeting system to N-terminal epitope tags; this also allows the generation of cell populations with heterologous expression control of the tagged locus via the copper-inducible mtnDE promoter. We present detailed, quantitative data on editing efficiencies for several genomic loci that may serve as positive controls or benchmarks in other laboratories. While our first PCR-based editing approach offered only blasticidin-resistance for selection, we now introduce puromycin-resistance as a second, independent selection marker; it is thus possible to edit two loci (e.g., for coimmunoprecipitation) without marker removal. Finally, we describe a modified FLP recombinase expression plasmid that improves the efficiency of marker cassette FLP-out. In summary, our technique and reagents enable a flexible, robust, and cloning-free genome editing approach that can be parallelized for scale-up.

  15. RNA Editing and Its Molecular Mechanism in Plant Organelles.

    PubMed

    Ichinose, Mizuho; Sugita, Mamoru

    2016-12-23

    RNA editing by cytidine (C) to uridine (U) conversions is widespread in plant mitochondria and chloroplasts. In some plant taxa, "reverse" U-to-C editing also occurs. However, to date, no instance of RNA editing has yet been reported in green algae and the complex thalloid liverworts. RNA editing may have evolved in early land plants 450 million years ago. However, in some plant species, including the liverwort, Marchantia polymorpha, editing may have been lost during evolution. Most RNA editing events can restore the evolutionarily conserved amino acid residues in mRNAs or create translation start and stop codons. Therefore, RNA editing is an essential process to maintain genetic information at the RNA level. Individual RNA editing sites are recognized by plant-specific pentatricopeptide repeat (PPR) proteins that are encoded in the nuclear genome. These PPR proteins are characterized by repeat elements that bind specifically to RNA sequences upstream of target editing sites. In flowering plants, non-PPR proteins also participate in multiple RNA editing events as auxiliary factors. C-to-U editing can be explained by cytidine deamination. The proteins discovered to date are important factors for RNA editing but a bona fide RNA editing enzyme has yet to be identified.

  16. RNA Editing and Its Molecular Mechanism in Plant Organelles

    PubMed Central

    Ichinose, Mizuho; Sugita, Mamoru

    2016-01-01

    RNA editing by cytidine (C) to uridine (U) conversions is widespread in plant mitochondria and chloroplasts. In some plant taxa, “reverse” U-to-C editing also occurs. However, to date, no instance of RNA editing has yet been reported in green algae and the complex thalloid liverworts. RNA editing may have evolved in early land plants 450 million years ago. However, in some plant species, including the liverwort, Marchantia polymorpha, editing may have been lost during evolution. Most RNA editing events can restore the evolutionarily conserved amino acid residues in mRNAs or create translation start and stop codons. Therefore, RNA editing is an essential process to maintain genetic information at the RNA level. Individual RNA editing sites are recognized by plant-specific pentatricopeptide repeat (PPR) proteins that are encoded in the nuclear genome. These PPR proteins are characterized by repeat elements that bind specifically to RNA sequences upstream of target editing sites. In flowering plants, non-PPR proteins also participate in multiple RNA editing events as auxiliary factors. C-to-U editing can be explained by cytidine deamination. The proteins discovered to date are important factors for RNA editing but a bona fide RNA editing enzyme has yet to be identified. PMID:28025543

  17. The Construction of Children's Character. Ninety-Sixth Yearbook of the National Society for the Study of Education. Part II.

    ERIC Educational Resources Information Center

    Molnar, Alex, Ed.

    1997-01-01

    This book presents a comprehensive and critical assessment of contemporary character education theory and practice from a variety of perspectives: historical, cultural, philosophical, psychological, empirical, political, and ethical. The essays in this book are divided into five sections intended to help develop a well-grounded understanding of…

  18. Refugee Students in Global Schools, Constructing Citizenship: A Comparative Case Study of Sixth Grade Classrooms in Two Public IB Schools

    ERIC Educational Resources Information Center

    Quaynor, Laura J.

    2012-01-01

    Although the United States resettles more refugee students than any other country, little research examines the ways that schools in the United States prepare these students to participate in their political community. At the same time, a growing number of schools serving refugee students are adopting curricula with a global focus. This research…

  19. Quantum Field Theory, Revised Edition

    NASA Astrophysics Data System (ADS)

    Mandl, F.; Shaw, G.

    1994-01-01

    Quantum Field Theory Revised Edition F. Mandl and G. Shaw, Department of Theoretical Physics, The Schuster Laboratory, The University, Manchester, UK When this book first appeared in 1984, only a handful of W± and Z° bosons had been observed and the experimental investigation of high energy electro-weak interactions was in its infancy. Nowadays, W± bosons and especially Z° bosons can be produced by the thousand and the study of their properties is a precise science. We have revised the text of the later chapters to incorporate these developments and discuss their implications. We have also taken this opportunity to update the references throughout and to make some improvements in the treatment of dimen-sional regularization. Finally, we have corrected some minor errors and are grateful to various people for pointing these out. This book is designed as a short and simple introduction to quantum field theory for students beginning research in theoretical and experimental physics. The three main objectives are to explain the basic physics and formalism of quantum field theory, to make the reader fully proficient in theory calculations using Feynman diagrams, and to introduce the reader to gauge theories, which play such a central role in elementary particle physics. The theory is applied to quantum electrodynamics (QED), where quantum field theory had its early triumphs, and to weak interactions where the standard electro-weak theory has had many impressive successes. The treatment is based on the canonical quantization method, because readers will be familiar with this, because it brings out lucidly the connection between invariance and conservation laws, and because it leads directly to the Feynman diagram techniques which are so important in many branches of physics. In order to help inexperienced research students grasp the meaning of the theory and learn to handle it confidently, the mathematical formalism is developed from first principles, its physical

  20. Gauge Field Theories, 2nd Edition

    NASA Astrophysics Data System (ADS)

    Frampton, Paul H.

    2000-08-01

    The first edition of Gauge Field Theories, published in 1985, quickly became widely used in universities and other institutions of higher learning around the world. Written by well-known physicist Paul Frampton, the new edition continues to offer a first-rate mathematical treatment of gauge field theories, while thoroughly updating all chapters to keep pace with developments in the field. Frampton emphasizes formalism rather than experiments and provides sufficient detail for readers wishing to do their own calculations or pursue theoretical physics research. Special features of the Second Edition include: * Improved, logical organization of the material on gauge invariance, quantization, and renormalization * Major revision of the chapter on electroweak interactions, incorporating the latest precision data and discovery of the top quark * Discussions of renormalization group and quantum chromodynamics * A completely new chapter on model building

  1. JICST Thesaurus : Compilation of the 1987 Edition

    NASA Astrophysics Data System (ADS)

    Saito, Kazuo; Sakagami, Yasuhiko; Totsuka, Takayuki; Okano, Hiroyuki; Shirayama, Kunihiko; Gomibuchi, Takeshi

    We had requests such as enlargement of terms to be covered in the Thesaurus, description of term history and so on through the questionnaires to JOIS users specifically conducted on the occasion of preparing 1987 edition of JICST Thesaurus. Based on them the following measures were taken : addition of new terms by referring natural words stored in JICST database, addition of some Chinese characters used for it, addition of priority data among synonyms and others, and improvement of term relations by using English translated Japanese keywords. How the Thesaurus was edited, and measures against problems associated with editing are described. Necessity of the routine maintenance and subjects to be solved from now on are also described.

  2. The Prospective Association Between Sipping Alcohol by the Sixth Grade and Later Substance Use

    PubMed Central

    Jackson, Kristina M.; Barnett, Nancy P.; Colby, Suzanne M.; Rogers, Michelle L.

    2015-01-01

    Objective: Although there is a clear association between early use of alcohol and short- and long-term adverse outcomes, it is unclear whether consumption of minor amounts of alcohol (less than a full drink) at a young age is prognostic of risk behaviors in later adolescence. Method: Data were taken from 561 students enrolled in an ongoing prospective web-based study on alcohol initiation and progression (55% female; 25% White non-Hispanic). Based on a combination of monthly and semiannual surveys, we coded whether participants sipped alcohol before sixth grade and examined associations between early sipping and alcohol consumption by fall of ninth grade, as well as other indices of problem behavior. Participants also reported on the context of the first sipping event. Results: The prevalence of sipping alcohol by fall of sixth grade was 29.5%. Most participants indicated that their first sip took place at their own home, and the primary source of alcohol was an adult, usually a parent. Youth who sipped alcohol by sixth grade had significantly greater odds of consuming a full drink, getting drunk, and drinking heavily by ninth grade than nonsippers. These associations held even when we controlled for temperamental, behavioral, and environmental factors that contribute to proneness for problem behavior, which suggests that sipping is not simply a marker of underlying risk. Conclusions: Our findings that early sipping is associated with elevated odds of risky behaviors at high school entry dispute the idea of sipping as a protective factor. Offering even just a sip of alcohol may undermine messages about the unacceptability of alcohol consumption for youth. PMID:25785796

  3. The impact of environmental education on sixth-grade students' science achievement

    NASA Astrophysics Data System (ADS)

    Clavijo, Katherine Gillespie

    This study investigated the relationship between student involvement in environmental education (EE) and science achievement. The performance of students engaged in fifth and sixth grade classrooms identified as incorporating environmental education into science instruction was compared to that of students from similar classrooms that use traditional science instruction. Data from 4655 sixth grade students were analyzed using hierarchical multiple regression model to determine if environmental education improves prediction of science achievement beyond that afforded by differences in socioeconomic status and previous science achievement. The results indicated that environmental education, when integrated into science instruction, does not improve prediction of CTBS science scores beyond that afforded by differences in previous achievement in science and socioeconomic status. Previous achievement and socioeconomic status were the only two variables that predicted CTBS science subtest scores. The variable previous achievement (Score on fourth grade KIRIS test) explained 27.6% of the variance in CTBS test scores. The variable socioeconomic status (participation in free and reduced lunch program) explained 7.1% of the variance in CTBS science test scores. Participation in a fifth, sixth or both grades environmental education classroom did not add to the prediction of CTBS scores. This study illustrates that environmental education, while not correlated with high science achievement, does not correlate with low science achievement. Environmental education research may benefit from similar studies, which utilize alternative forms of student assessment. This study has implications for researchers interested in examining the impact of environmental education on science achievement, as it provides evidence for the importance of including background characteristics, such as socioeconomic status and previous achievement, in research models. This study provides an example of

  4. Concurrent Validity of the Stanford-Binet Fourth Edition and K-ABC for Head Start Children.

    ERIC Educational Resources Information Center

    Krohn, Emily J.; Lamp, Robert E.

    1989-01-01

    Investigated validity of Stanford-Binet Intelligence Scale-Fourth Edition and Kaufman Assessment Battery for Children with 89 preschool Head Start children from low-income families, using Stanford-Binet Intelligence Scale-Form LM as criterion measure. Found some support for concurrent and construct validity of both instruments for use with…

  5. Confirmatory Factor Structure of the Kaufman Assessment Battery for Children-Second Edition with Preschool Children: Too Young for Differentiation?

    ERIC Educational Resources Information Center

    Potvin, Deborah C. H.; Keith, Timothy Z.; Caemmerer, Jacqueline M.; Trundt, Katherine M.

    2015-01-01

    With an age range from 3 to 13 years, the Kaufman Assessment Battery for Children-Second Edition (KABC-II) offers an appealing option for the assessment of cognitive abilities for children. Although independent research has provided evidence of the construct validity of the KABC-II for school-age children, previous studies have rarely included an…

  6. Pipe line rules of thumb handbook. Fourth edition

    SciTech Connect

    McAllister, E.W.

    1998-12-01

    This revised fourth edition contains an updated collection of straightforward, common-sense techniques that provide quick solutions to pipeline problems. This book is the foundation of the pipeline library with its hundreds of shortcuts, calculations, and practical how-to methods. Whether concerned with design, construction, or engineering for oil, gas, or products pipelines, one will find fast answers here. This easy-to-read book provides new conversion tables and valuable new information on basic mathematical formulas (areas, surfaces, and volumes), stress in guy wires, land descriptions, polypipe design data, floodlighting concepts, marine hose data, rotary screw pumps, and much more. One will learn how to estimate leakage and determine batch injection rates. The chapters on electrical design, liquids, and economics have been significantly expanded.

  7. Interactive applications for sketch-based editable polycube map.

    PubMed

    Garcia, Ismael; Xia, Jiazhi; He, Ying; Xin, Shi-Qing; Patow, Gustavo

    2013-07-01

    In this paper, we propose a sketch-based editable polycube mapping method that, given a general mesh and a simple polycube that coarsely resembles the shape of the object, plus sketched features indicating relevant correspondences between the two, provides a uniform, regular, and user-controllable quads-only mesh that can be used as a basis structure for subdivision. Large scale models with complex geometry and topology can be processed efficiently with simple, intuitive operations. We show that the simple, intuitive nature of the polycube map is a substantial advantage from the point of view of the interface by demonstrating a series of applications, including kit-basing, shape morphing, painting over the parameterization domain, and GPU-friendly tessellated subdivision displacement, where the user is also able to control the number of patches in the base mesh by the construction of the base polycube.

  8. Sixth Microgravity Fluid Physics and Transport Phenomena Conference: Exposition Topical Areas 1-6. Volume 2

    NASA Technical Reports Server (NTRS)

    Singh, Bhim (Compiler)

    2002-01-01

    The Sixth Microgravity Fluid Physics and Transport Phenomena Conference provides the scientific community the opportunity to view the current scope of the Microgravity Fluid Physics and Transport Phenomena Program, current research opportunities, and plans for the near future. The conference focuses not only on fundamental research but also on applications of this knowledge towards enabling future space exploration missions. A whole session dedicated to biological fluid physics shows increased emphasis that the program has placed on interdisciplinary research. The conference includes invited plenary talks, technical paper presentations, poster presentations, and exhibits. This CP (conference proceeding) is a compilation of the abstracts, presentations, and posters presented at the conference.

  9. Proceedings of the sixth international conference on electronics for particle physics

    SciTech Connect

    Blanar, G.J.; Sumner, R.L.

    1997-12-31

    The Sixth Conference on Electronics for Particle Physics continued the LeCroy tradition of providing a unique forum for the leaders in the field to meet, report and compare notes on what has become one of the most important (and expensive) components of a particle physics physics experiments today. As our field continues to depend on special electronics developed for particle physics to even make the experiments possible, this conference, along with the IEEE National Science Symposium and the LHC Electronics Conference have become essential if we are to meet the experiment`s severe time and financial commitments.

  10. Sixth International Conference on Precipitation: Predictability of Rainfall at the Various Scales. Abstracts

    SciTech Connect

    1998-06-29

    This volume contains abstracts of the papers presented at the Sixth International Conference on Precipitation: Predictability of Rainfall at the various scales, held at the Mauna Lani Bay and Bungalows, Hawaii, June 29 - July 1, 1998. The main goal of the conference was to bring together meteorologists, hydrologists, mathematicians, physicists, statisticians, and all others who are interested in fundamental principles governing the physical processes of precipitation. The results of the previous conferences have been published in issues of the Journal of Geophysical Research and Journal of Applied Meteorology. A similar format is planned for papers of this conference.

  11. Sixth grade students' perceptions of science and scientists following a field-based science investigation

    NASA Astrophysics Data System (ADS)

    Kielborn, Terrie Leigh

    The purpose of this study was to better understand the influences of field-based investigations on sixth graders' perceptions of science and scientists. I chose to do this study due to my desire for middle grade students to have the opportunity to learn science as scientists, to increase their interest in science, and to create a positive attitude about science at the middle school level. The implications of the findings are directed toward the future of middle school science education. Thirty-five students from two sixth grade classes drew their perceptions of a scientist using the Draw-A-Scientists Test (DAST), before and after their participation in a field-based science investigation. Three students were interviewed prior to, between each, and after the field-based investigations. Using the pre-DAST and post-DAST drawings along with the conversations of the students, I found three significant differences that indicated a change in the students' perception of scientists: (1) youth; (2) outdoors; and (3) symbols of research. Prior to the study, 74% of the sixth graders viewed scientists as middle-aged or elderly as compared to 43% after the stream investigations. The stream as "the site" for the field-based investigations, influenced 57% of the students to include the outdoors in their post-DAST drawings as compared to 26% in the pre-DAST. Students drew symbols of research 43% on the pre-DAST but increased to 69% on the post-DAST. Many of the drawings and conversations from the confirm the notion that these sixth graders preferred to learn science outside and using scientific tools. These students felt that they were doing real science, and real science is what scientists do. By using field-based science investigations regularly, I believe there is the potential for putting students on the frontier of science. This goal aligns with the National Science Education Standards that call for students to have opportunities for "inquiry into authentic questions

  12. The Sixth SeaWiFS/SIMBIOS Intercalibration Round-Robin Experiment (SIRREX-6)

    NASA Technical Reports Server (NTRS)

    Riley, Thomas; Bailey, Sean

    1998-01-01

    For the sixth Sea-Viewing Wide Field-of-View Sensor (SeaWiFS) Intercalibration Round-Robin Experiment (SIRREX-6), NASA personnel carried the same four Satlantic in-water radiometers to nine separate laboratories and calibrated them. Two of the sensors were seven-channel radiance heads and two were seven-channel irradiance heads. The calibration and data reduction procedures used at each site followed that laboratory's normal procedures. The reference lamps normally used for the calibration of these types of instruments by the various laboratories were also used for this experiment. NASA personnel processed the data to produce calibration parameters from the various laboratories

  13. Therapeutic Genome Editing: Prospects and Challenges

    PubMed Central

    Cox, David Benjamin Turitz; Platt, Randall Jeffrey; Zhang, Feng

    2015-01-01

    Recent advances in the development of genome editing technologies based on programmable nucleases have significantly improved our ability to make precise changes in the genomes of eukaryotic cells. Genome editing is already broadening our ability to elucidate the contribution of genetics to disease by facilitating the creation of more accurate cellular and animal models of pathological processes. A particularly tantalizing application of programmable nucleases is the potential to directly correct genetic mutations in affected tissues and cells to treat diseases that are refractory to traditional therapies. Here we discuss current progress towards developing programmable nuclease-based therapies as well as future prospects and challenges. PMID:25654603

  14. Astronomy For Dummies, 2nd Edition

    NASA Astrophysics Data System (ADS)

    Maran, Stephen P.

    2005-04-01

    An accessible guide to the wonders of the night sky, now updated From asteroids to black holes, from quasars to white dwarfs, this new edition of Astronomy For Dummies takes backyard stargazers on a grand tour of the universe. Featuring star maps, charts, gorgeous full-color photographs, and easy-to-follow explanations, this fact-filled guide gives readers a leg up on the basic principles of astronomy and shows how to get the most out of binoculars, telescopes, planetarium visits, and other fun astronomical activities. This updated edition includes an updated color signature and covers the many discoveries made in recent years, as well as new astronomy Web sites.

  15. Transportation Energy Data Book, Edition 19

    SciTech Connect

    Davis, S.C.

    1999-09-01

    The Transportation Energy Data Book: Edition 19 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (http://www-cta.ornl.gov/data/tedb.htm).

  16. Shielded Metal Arc Welding and Carbon Arc Cutting--Air. Teacher Edition [and] Student Edition [and] Student Workbook. Third Edition.

    ERIC Educational Resources Information Center

    Harper, Eddie; Knapp, John

    This document contains the teacher and student texts and student workbook for a secondary-level course in shielded metal arc welding (SMAW) and carbon arc cutting that consists of units on the following topics: SMAW safety; SMAW equipment, applications, and techniques; hardfacing; and carbon arc cutting--air. The teacher edition includes the…

  17. Construction aggregates

    USGS Publications Warehouse

    Tepordei, V.V.

    1995-01-01

    Part of the 1994 Industrial Minerals Review. The production, consumption, and applications of construction aggregates are reviewed. In 1994, the production of construction aggregates, which includes crushed stone and construction sand and gravel combined, increased 7.7 percent to 2.14 Gt compared with the previous year. These record production levels are mostly a result of funding for highway construction work provided by the Intermodal Surface Transportation Efficiency Act of 1991. Demand is expected to increase for construction aggregates in 1995.

  18. TALENs Construction: Slowly but Surely.

    PubMed

    Hegazy, Wael Abdel Halim; Youns, Mahmoud

    2016-01-01

    Cancer is thought to be a direct result of transcriptional misregulation. Broad analysis of transcriptional regulatory elements in healthy and cancer cells is needed to understand cancer development. Nucleases regulatory domains are recruited to bind and manipulate a specific genomic locus with high efficacy and specificity. TALENs (transcription activatorlike effector nuclease) fused to endonuclease FokI have been used widely to target specific sequences to edit several genes in healthy and cancer cells. This approach is promising to target specific cancer genes and for this purpose it is needed to pack such TALENs into viral vectors. There are some considerations which control the success of this approach, targeting appropriate sequences with efficient construction of TALENs being crucial factors. We face some obstacles in construction of TALENs; in this study we made a modification to the method of Cermk et al 2011 and added one step to make it easier and increase the availability of constructs.

  19. The Chloroplast Genome of Pellia endiviifolia: Gene Content, RNA-Editing Pattern, and the Origin of Chloroplast Editing

    PubMed Central

    Grosche, Christopher; Funk, Helena T.; Maier, Uwe G.; Zauner, Stefan

    2012-01-01

    RNA editing is a post-transcriptional process that can act upon transcripts from mitochondrial, nuclear, and chloroplast genomes. In chloroplasts, single-nucleotide conversions in mRNAs via RNA editing occur at different frequencies across the plant kingdom. These range from several hundred edited sites in some mosses and ferns to lower frequencies in seed plants and the complete lack of RNA editing in the liverwort Marchantia polymorpha. Here, we report the sequence and edited sites of the chloroplast genome from the liverwort Pellia endiviifolia. The type and frequency of chloroplast RNA editing display a pattern highly similar to that in seed plants. Analyses of the C to U conversions and the genomic context in which the editing sites are embedded provide evidence in favor of the hypothesis that chloroplast RNA editing evolved to compensate mutations in the first land plants. PMID:23221608

  20. The chloroplast genome of Pellia endiviifolia: gene content, RNA-editing pattern, and the origin of chloroplast editing.

    PubMed

    Grosche, Christopher; Funk, Helena T; Maier, Uwe G; Zauner, Stefan

    2012-01-01

    RNA editing is a post-transcriptional process that can act upon transcripts from mitochondrial, nuclear, and chloroplast genomes. In chloroplasts, single-nucleotide conversions in mRNAs via RNA editing occur at different frequencies across the plant kingdom. These range from several hundred edited sites in some mosses and ferns to lower frequencies in seed plants and the complete lack of RNA editing in the liverwort Marchantia polymorpha. Here, we report the sequence and edited sites of the chloroplast genome from the liverwort Pellia endiviifolia. The type and frequency of chloroplast RNA editing display a pattern highly similar to that in seed plants. Analyses of the C to U conversions and the genomic context in which the editing sites are embedded provide evidence in favor of the hypothesis that chloroplast RNA editing evolved to compensate mutations in the first land plants.