Sample records for continuous mixed simplified

  1. Simplified stock markets described by number operators

    NASA Astrophysics Data System (ADS)

    Bagarello, F.

    2009-06-01

    In this paper we continue our systematic analysis of the operatorial approach previously proposed in an economical context and we discuss a mixed toy model of a simplified stock market, i.e. a model in which the price of the shares is given as an input. We deduce the time evolution of the portfolio of the various traders of the market, as well as of other observable quantities. As in a previous paper, we solve the equations of motion by means of a fixed point like approximation.

  2. A Depth-Averaged 2-D Simulation for Coastal Barrier Breaching Processes

    DTIC Science & Technology

    2011-05-01

    including bed change and variable flow density in the flow continuity and momentum equations. The model adopts the HLL approximate Riemann solver to handle...flow density in the flow continuity and momentum equations. The model adopts the HLL approximate Riemann solver to handle the mixed-regime flows near...18 547 Keulegan equation or the Bernoulli equation, and the breach morphological change is determined using simplified sediment transport models

  3. A method for fitting regression splines with varying polynomial order in the linear mixed model.

    PubMed

    Edwards, Lloyd J; Stewart, Paul W; MacDougall, James E; Helms, Ronald W

    2006-02-15

    The linear mixed model has become a widely used tool for longitudinal analysis of continuous variables. The use of regression splines in these models offers the analyst additional flexibility in the formulation of descriptive analyses, exploratory analyses and hypothesis-driven confirmatory analyses. We propose a method for fitting piecewise polynomial regression splines with varying polynomial order in the fixed effects and/or random effects of the linear mixed model. The polynomial segments are explicitly constrained by side conditions for continuity and some smoothness at the points where they join. By using a reparameterization of this explicitly constrained linear mixed model, an implicitly constrained linear mixed model is constructed that simplifies implementation of fixed-knot regression splines. The proposed approach is relatively simple, handles splines in one variable or multiple variables, and can be easily programmed using existing commercial software such as SAS or S-plus. The method is illustrated using two examples: an analysis of longitudinal viral load data from a study of subjects with acute HIV-1 infection and an analysis of 24-hour ambulatory blood pressure profiles.

  4. Existence and stability, and discrete BB and rank conditions, for general mixed-hybrid finite elements in elasticity

    NASA Technical Reports Server (NTRS)

    Xue, W.-M.; Atluri, S. N.

    1985-01-01

    In this paper, all possible forms of mixed-hybrid finite element methods that are based on multi-field variational principles are examined as to the conditions for existence, stability, and uniqueness of their solutions. The reasons as to why certain 'simplified hybrid-mixed methods' in general, and the so-called 'simplified hybrid-displacement method' in particular (based on the so-called simplified variational principles), become unstable, are discussed. A comprehensive discussion of the 'discrete' BB-conditions, and the rank conditions, of the matrices arising in mixed-hybrid methods, is given. Some recent studies aimed at the assurance of such rank conditions, and the related problem of the avoidance of spurious kinematic modes, are presented.

  5. Optimisation of strain selection in evolutionary continuous culture

    NASA Astrophysics Data System (ADS)

    Bayen, T.; Mairet, F.

    2017-12-01

    In this work, we study a minimal time control problem for a perfectly mixed continuous culture with n ≥ 2 species and one limiting resource. The model that we consider includes a mutation factor for the microorganisms. Our aim is to provide optimal feedback control laws to optimise the selection of the species of interest. Thanks to Pontryagin's Principle, we derive optimality conditions on optimal controls and introduce a sub-optimal control law based on a most rapid approach to a singular arc that depends on the initial condition. Using adaptive dynamics theory, we also study a simplified version of this model which allows to introduce a near optimal strategy.

  6. Investigation of the Mixing Behavior and the Generation of Contact-Area in a Continuous Twin-Shaft Kneader

    NASA Astrophysics Data System (ADS)

    Seck, Oliver; Maxisch, Tobias; Bothe, Dieter; Warnecke, Hans-Joachim

    2010-03-01

    The technical synthesis and processing of polymer materials is the basis for major branches of the chemical industry. Well introduced for high-viscosity processes are screw extruders. However, in case of large residence times, a kneader with its large volume is more appropriate, but the latter still requires further understanding for intensification purposes. First, the axial mixing behavior is characterized by studying the residence time distribution under continuous operation. For this purpose silicone oil of high viscosity is used as kneading material. At the inlet dye tracer is injected and detected at the outlet via photometry. The response functions show that the classical dispersion model leads to an appropriate description of the experimental data. By means of a fast chemical reaction of second order the radial mixing behavior including transport on the molecular scale is studied. The generation of contact-area between two fluid elements, each one charged with one of the educts is the characteristic quantity since the two reactants cannot coexist and, hence, react directly at the interface. Thus the amount of detected product is a measure for the contact-area produced by kneading. Based on these data, a simplified model for the mixing process in the kneader is developed.

  7. Combined Microfluidic-Eectric Diffused Mixing of Living Cells in Continuous Flow

    NASA Astrophysics Data System (ADS)

    Ming-Wen Wang,

    2010-02-01

    The mixing process is a crucially important stage in the operation of biological and chemical microfluidic devices. If the mixing is inadequate, reactants do not fully interact with each other, and the device may not operate properly. This paper describes a simplified microfluidic mixer (different from a chaotic mixer) which can uniformly mix a buffer solution with living cells by applying an AC electric charge. Diffusion of the living cells into the buffer solution occurs rapidly following the interface of the flow stream with the electric charge; no further agitating step is needed. To accomplish this, an asymmetric pair of electrodes was integrated at the inlets of the buffer solution and the cells fluid. When the buffer solution and the cells fluid were introduced into one flow path, they remained limited to that flow stream. When the electrodes were charged, however, the cells in a short distance were efficiently moved into the solution flow, and the original fluids were mixed. The mixing efficiency depends on the polarizability of the cells, and this in turn is governed by the dielectric properties of the cells, the medium, and the solvent. This micro device, capable of efficiently mixing living cells with a buffer solution, may potentially allow biological mixing to be done outside of hospitals, in facilities without biological analyzing instruments.

  8. Realistic simplified gaugino-higgsino models in the MSSM

    NASA Astrophysics Data System (ADS)

    Fuks, Benjamin; Klasen, Michael; Schmiemann, Saskia; Sunder, Marthijn

    2018-03-01

    We present simplified MSSM models for light neutralinos and charginos with realistic mass spectra and realistic gaugino-higgsino mixing, that can be used in experimental searches at the LHC. The formerly used naive approach of defining mass spectra and mixing matrix elements manually and independently of each other does not yield genuine MSSM benchmarks. We suggest the use of less simplified, but realistic MSSM models, whose mass spectra and mixing matrix elements are the result of a proper matrix diagonalisation. We propose a novel strategy targeting the design of such benchmark scenarios, accounting for user-defined constraints in terms of masses and particle mixing. We apply it to the higgsino case and implement a scan in the four relevant underlying parameters {μ , tan β , M1, M2} for a given set of light neutralino and chargino masses. We define a measure for the quality of the obtained benchmarks, that also includes criteria to assess the higgsino content of the resulting charginos and neutralinos. We finally discuss the distribution of the resulting models in the MSSM parameter space as well as their implications for supersymmetric dark matter phenomenology.

  9. The Effect of Simplified Bonding Agents on the Bond Strength to Dentin of Self-Activated Dual-Cure Resin Cements

    DTIC Science & Technology

    2013-04-26

    versions of the self-etch adhesives on the market are one-step systems where the acidified primer and adhesive monomer are mixed together and placed in a...Figure 3 - Adhesive Classification B. Effects of Simplification at the Microscopic level Using restorative systems with simplified...bonding failures when self-cured “build-up” composites were bonded with simplified adhesive systems (Swift, 1999). They were alerted to potential

  10. Four-Wave-Mixing Oscillations in a simplified Boltzmannian semiconductor model with LO-phonons

    NASA Astrophysics Data System (ADS)

    Tamborenea, P. I.; Bányai, L.; Haug, H.

    1996-03-01

    The recently discovered(L. Bányai, D. B. Tran Thoai, E. Reitsamer, H. Haug, D. Steinbach, M. U. Wehner, M. Wegener, T. Marschner and W. Stolz, Phys. Rev. Lett. 75), 2188 (1995). oscillations of the integrated four-wave-mixing signal in semiconductors due to electron-LO-phonon scattering are studied within a simplified Boltzmann-type model. Although several aspects of the experimental results require a description within the framework of non-Markovian quantum-kinetic theory, our simplified Boltzmannian model is well suited to analyze the origin of the observed novel oscillations of frequency (1+m_e/m_h) hbarω_LO. To this end, we developed a third-order, analytic solution of the semiconductor Bloch equations (SBE) with Boltzmann-type, LO-phonon collision terms. Results of this theory along with numerical solutions of the SBE will be presented.

  11. Text-Based Recall and Extra-Textual Generations Resulting from Simplified and Authentic Texts

    ERIC Educational Resources Information Center

    Crossley, Scott A.; McNamara, Danielle S.

    2016-01-01

    This study uses a moving windows self-paced reading task to assess text comprehension of beginning and intermediate-level simplified texts and authentic texts by L2 learners engaged in a text-retelling task. Linear mixed effects (LME) models revealed statistically significant main effects for reading proficiency and text level on the number of…

  12. Interactions between marine biota and ENSO: a conceptual model analysis

    NASA Astrophysics Data System (ADS)

    Heinemann, M.; Timmermann, A.; Feudel, U.

    2011-01-01

    We develop a conceptual coupled atmosphere-ocean-ecosystem model for the tropical Pacific to investigate the interaction between marine biota and the El Niño-Southern Oscillation (ENSO). Ocean and atmosphere are represented by a two-box model for the equatorial Pacific cold tongue and the warm pool, including a simplified mixed layer scheme. Marine biota are represented by a three-component (nutrient, phytoplankton, and zooplankton) ecosystem model. The atmosphere-ocean model exhibits an oscillatory state which qualitatively captures the main physics of ENSO. During an ENSO cycle, the variation of nutrient upwelling, and, to a small extent, the variation of photosynthetically available radiation force an ecosystem oscillation. The simplified ecosystem in turn, due to the effect of phytoplankton on the absorption of shortwave radiation in the water column, leads to (1) a warming of the tropical Pacific, (2) a reduction of the ENSO amplitude, and (3) a prolongation of the ENSO period. We qualitatively investigate these bio-physical coupling mechanisms using continuation methods. It is demonstrated that bio-physical coupling may play a considerable role in modulating ENSO variability.

  13. Periodontal disease detection in primary and mixed dentitions.

    PubMed

    Nobre, C M Guimarães; Fernandes-Costa, A N; de Melo Soares, M S; Pugliesi, D M Carvalho; de Vasconcelos Gurgel, B C

    2016-10-01

    This was to compare the periodontal status of children with primary and mixed dentition at the time of their first consultation. Children (200), aged 0-12 years (156 with mixed and 44 with primary dentition), were examined by assessing their simplified plaque index (PI) and simplified periodontal record (PSR). Statistical analysis (Chi-square test) was performed with appropriate software to find any significant associations between sex, type of dentition and PI with the PSR codes (0, 1, 2, 3 and 4). There was no statistically significant difference with regard to gender (p = 0.82). Generalised PI was associated more significantly with mixed dentition (p = 0.025 and higher PSR scores (p < 0.001). There was no significant relationship between sex and PSR codes (p = 0.82). Children presenting with a mixed dentition had worse PI values and PSR scores. It is important to perform periodontal examination in children to diagnose and prevent future periodontal disease and maintain their dentition as well as to identify any associated systemic conditions.

  14. Ill-posedness in modeling mixed sediment river morphodynamics

    NASA Astrophysics Data System (ADS)

    Chavarrías, Víctor; Stecca, Guglielmo; Blom, Astrid

    2018-04-01

    In this paper we analyze the Hirano active layer model used in mixed sediment river morphodynamics concerning its ill-posedness. Ill-posedness causes the solution to be unstable to short-wave perturbations. This implies that the solution presents spurious oscillations, the amplitude of which depends on the domain discretization. Ill-posedness not only produces physically unrealistic results but may also cause failure of numerical simulations. By considering a two-fraction sediment mixture we obtain analytical expressions for the mathematical characterization of the model. Using these we show that the ill-posed domain is larger than what was found in previous analyses, not only comprising cases of bed degradation into a substrate finer than the active layer but also in aggradational cases. Furthermore, by analyzing a three-fraction model we observe ill-posedness under conditions of bed degradation into a coarse substrate. We observe that oscillations in the numerical solution of ill-posed simulations grow until the model becomes well-posed, as the spurious mixing of the active layer sediment and substrate sediment acts as a regularization mechanism. Finally we conduct an eigenstructure analysis of a simplified vertically continuous model for mixed sediment for which we show that ill-posedness occurs in a wider range of conditions than the active layer model.

  15. Towards optimization of an organotypic assay system that imitates human hair follicle-like epithelial-mesenchymal interactions.

    PubMed

    Havlickova, B; Bíró, T; Mescalchin, A; Arenberger, P; Paus, R

    2004-10-01

    Human hair growth can currently be studied in vitro by the use of organ-cultured scalp hair follicles (HFs). However, simplified organotypic systems are needed for dissecting the underlying epithelial-mesenchymal interactions and as screening tools for candidate hair growth-modulatory agents. To optimize the design and culture conditions of previously published organotypic systems that imitate epithelial-mesenchymal interactions in the human HF as closely as possible. Continuous submerged organotypic 'sandwich' cultures were established. These consist of a pseudodermis (collagen I mixed with and contracted by human interfollicular dermal fibroblasts) on which one of two upper layers is placed: either a mixture of Matrigel basement membrane matrix (BD Biosciences, Bedford, MA, U.S.A.) and follicular dermal papilla fibroblasts (DPC), with outer root sheath keratinocytes (ORSK) layered on the top ('layered' system), or a mixture of Matrigel, DPC and ORSK ('mixed' system). Morphological and functional characteristics of these 'folliculoid sandwiches' were then assessed by routine histology, histomorphometry and immunohistochemistry. In both 'layered' and 'mixed' systems, the ORSK formed spheroid epithelial cell aggregates, which retained their characteristic keratin expression pattern (i.e. cytokeratin 6). In the 'mixed' sandwich model the size of the epithelial cell aggregates was smaller, but the numbers of ORSK were significantly higher than in the 'layered' model at day 14 in the culture. ORSK proliferated better in the 'mixed' than in the 'layered' sandwich system, regardless of the calcium or serum content of the media, whereas apoptosis of ORSK was lowest in the 'mixed' system in serum-free, low calcium medium. The kinetics of proliferation and apoptosis of DPC, which retained their characteristic expression of versican, were similar in both systems. However, proliferation and apoptosis of DPC were higher in the presence of serum and/or under high calcium conditions. Our results underscore the importance of structural design and medium composition for epithelial-mesenchymal interactions as they occur in the human HF. Specifically, we report a new organotypic submerged 'folliculoid sandwich' system with serum-free, low calcium medium and a mixture of interacting human DPC and ORSK, which offers several advantages over previously available assays. This system allows the standardized assessment of the effects of a test agent on the proliferation, apoptosis and key marker expression of human ORSK and DPC under substantially simplified in vitro conditions which approximate the in vivo situation.

  16. 7 CFR 273.25 - Simplified Food Stamp Program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Simplified Food Stamp Program. 273.25 Section 273.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS § 273.25 Simplified...

  17. 29 CFR 2700.103 - Party request for simplified proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Party request for simplified proceedings. 2700.103 Section 2700.103 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW... request for Simplified Proceedings is denied, the period for filing an answer will begin to run upon...

  18. [Simplified laparoscopic gastric bypass. Initial experience].

    PubMed

    Hernández-Miguelena, Luis; Maldonado-Vázquez, Angélica; Cortes-Romano, Pablo; Ríos-Cruz, Daniel; Marín-Domínguez, Raúl; Castillo-González, Armando

    2014-01-01

    Obesity surgery includes various gastrointestinal procedures. Roux-en-Y gastric bypass is the prototype of mixed procedures being the most practiced worldwide. A similar and novel technique has been adopted by Dr. Almino Cardoso Ramos and Dr. Manoel Galvao called "simplified bypass," which has been accepted due to the greater ease and very similar results to the conventional technique. The aim of this study is to describe the results of the simplified gastric bypass for treatment of morbid obesity in our institution. We performed a descriptive, retrospective study of all patients undergoing simplified gastric bypass from January 2008 to July 2012 in the obesity clinic of a private hospital in Mexico City. A total of 90 patients diagnosed with morbid obesity underwent simplified gastric bypass. Complications occurred in 10% of patients; these were more frequent bleeding and internal hernia. Mortality in the study period was 0%. The average weight loss at 12 months was 72.7%. Simplified gastric bypass surgery is safe with good mid-term results and a loss of adequate weight in 71% of cases.

  19. An Ecological Context for Regenerating Mult-cohort, Mixed-species Red Pine Forests

    Treesearch

    Brian Palik; John Zasada

    2003-01-01

    Human disturbances have simplified the structure and composition of red pine forest, relative to historical conditions. A greater understanding of natureal disturbances and their role in generating complex stand structures, and their associated benefits, has increased interest in managing for mixed-species, multi-aged stands. We outline a conceptual approach for...

  20. Self-consistent Dark Matter simplified models with an s-channel scalar mediator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bell, Nicole F.; Busoni, Giorgio; Sanderson, Isaac W., E-mail: n.bell@unimelb.edu.au, E-mail: giorgio.busoni@unimelb.edu.au, E-mail: isanderson@student.unimelb.edu.au

    We examine Simplified Models in which fermionic DM interacts with Standard Model (SM) fermions via the exchange of an s -channel scalar mediator. The single-mediator version of this model is not gauge invariant, and instead we must consider models with two scalar mediators which mix and interfere. The minimal gauge invariant scenario involves the mixing of a new singlet scalar with the Standard Model Higgs boson, and is tightly constrained. We construct two Higgs doublet model (2HDM) extensions of this scenario, where the singlet mixes with the 2nd Higgs doublet. Compared with the one doublet model, this provides greater freedommore » for the masses and mixing angle of the scalar mediators, and their coupling to SM fermions. We outline constraints on these models, and discuss Yukawa structures that allow enhanced couplings, yet keep potentially dangerous flavour violating processes under control. We examine the direct detection phenomenology of these models, accounting for interference of the scalar mediators, and interference of different quarks in the nucleus. Regions of parameter space consistent with direct detection measurements are determined.« less

  1. A Randomized Multicenter Clinical Trial of RPH With the Simplified Milligan-Morgan Hemorrhoidectomy in the Treatment of Mixed Hemorrhoids.

    PubMed

    He, Yong-Heng; Tang, Zhi-Jun; Xu, Xiang-Tong; Huang, De-Quan; Zhang, Li-Shun; Tang, Qing-Zhu; Fan, Zhi-Min; Zou, Xian-Jun; Zou, Guo-Jun; Zhang, Chong-Yang; Hu, Fan; Xie, Biao; Li, Yan-Hua; Tong, Yao; Liu, Hong-Chang; Li, Ke; Luo, Yu-Lian; Liu, Fei; Situ, Guang-Wei; Liu, Zuo-Long

    2017-12-01

    To explore the safety and efficacy of Ruiyun procedure for hemorrhoids (RPH) or RPH with the simplified Milligan-Morgan hemorrhoidectomy (sMMH) in the treatment of mixed hemorrhoids. This is a randomized, controlled, balanced, multicenter study of 3000 patients with mixed hemorrhoids. The outcomes and postoperative complications were compared between 5 types of surgeries. The efficacy rate was the highest in patients who received RPH+sMMH and decreased in the following order: patients who received RPH alone, MMH alone, procedure for prolapse and hemorrhoids (PPH) alone, and PPH+sMMH ( P < .05). The operation time was the shortest in patients who received RPH alone and increased in the following order: patients who received RPH+sMMH, PPH alone, MMH alone, and PPH+sMMH ( P < .01). The duration of postoperative hospitalization stay was the shortest in patients who received RPH alone and increased in the following order: PPH alone, RPH+sMMH, PPH+sMMH, and MMH alone ( P < .01). The incidence of postoperative hemorrhage, uroschesis, anal fissure, crissum hematoma or thrombosis, and anorectal stenosis was significantly lower in patients who received RPH+sMMH than in patients who received the other 4 types of surgical treatments ( P < .05, P < .01). No significant differences in postoperative rectovaginal fistula and anal incontinence were observed between the 5 groups of patients. RPH with or without simplified MMH can reduce the incidence of postoperative complications and improve the curative efficacy in the treatment of patients with mixed hemorrhoids.

  2. Mixed-species forest ecosystems in the Great Lakes region: A bibliography

    Treesearch

    John P. Gerlach; Daniel W. Gilmore; Klaus J. Puettmann; John C. Zasada

    2002-01-01

    Most of the world?s forests are dominated by mixed species stands but until recently, most forest management activities have focused on the development of single-species stands. To maximize fiber production, monoculture plantations were preferred because management and growth and yield prediction were simplified. This model of forest management developed because the...

  3. A solid ceramic electrolyte system for measuring redox conditions in high temperature gas mixing studies

    NASA Technical Reports Server (NTRS)

    Williams, R. J.

    1972-01-01

    The details of the construction and operation of a gas mixing furnace are presented. A solid ceramic oxygen electrolyte cell is used to monitor the oxygen fugacity in the furnace. The system consists of a standard vertical-quench, gas mixing furnace with heads designed for mounting the electrolyte cell and with facilities for inserting and removing the samples. The system also contains the highinput impedance electronics necessary for measurements and a simplified version of standard gas mixing apparatus. The calibration and maintenance of the system are discussed.

  4. Towards the next generation of simplified Dark Matter models

    NASA Astrophysics Data System (ADS)

    Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

    2017-06-01

    This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

  5. Transforce lingual appliances pre-adjusted invisible appliances simplify treatment.

    PubMed

    Clark, William John

    2011-01-01

    Transforce lingual appliances are designed to be used in conjunction with conventional fixed appliances. Lingual arch development is normally followed by bonded fixed appliances to detail the occlusion. Alternatively Transforce appliance treatment is an efficient method of preparing complex malocclusions prior to a finishing stage with invisible appliances. This approach is ideal for adult treatment, using light continuous forces for arch development with appliances that are comfortable to wear. Sagittal and Transverse appliances are designed for arch development in a range of sizes for contracted arches. They can be used to treat all classes of malocclusion and are pre-adjusted fixed/removable devices for non-compliance treatment. Force modules with nickel titanium coil springs enclosed in a tube deliver a gentle, biocompatible continuous force with a long range of action. They are excellent for mixed dentition and ideal for adult arch development. There are multiple sizes for upper and lower arch development and a sizing chart may be placed over a study model for correct selection, eliminating the need for laboratory work.

  6. Theory of Genuine Tripartite Nonlocality of Gaussian States

    NASA Astrophysics Data System (ADS)

    Adesso, Gerardo; Piano, Samanta

    2014-01-01

    We investigate the genuine multipartite nonlocality of three-mode Gaussian states of continuous variable systems. For pure states, we present a simplified procedure to obtain the maximum violation of the Svetlichny inequality based on displaced parity measurements, and we analyze its interplay with genuine tripartite entanglement measured via Rényi-2 entropy. The maximum Svetlichny violation admits tight upper and lower bounds at fixed tripartite entanglement. For mixed states, no violation is possible when the purity falls below 0.86. We also explore a set of recently derived weaker inequalities for three-way nonlocality, finding violations for all tested pure states. Our results provide a strong signature for the nonclassical and nonlocal nature of Gaussian states despite their positive Wigner function, and lead to precise recipes for its experimental verification.

  7. The influence of a wind tunnel on helicopter rotational noise: Formulation of analysis

    NASA Technical Reports Server (NTRS)

    Mosher, M.

    1984-01-01

    An analytical model is discussed that can be used to examine the effects of wind tunnel walls on helicopter rotational noise. A complete physical model of an acoustic source in a wind tunnel is described and a simplified version is then developed. This simplified model retains the important physical processes involved, yet it is more amenable to analysis. The simplified physical model is then modeled as a mathematical problem. An inhomogeneous partial differential equation with mixed boundary conditions is set up and then transformed into an integral equation. Details of generating a suitable Green's function and integral equation are included and the equation is discussed and also given for a two-dimensional case.

  8. Microfluidic mixing through oscillatory transverse perturbations

    NASA Astrophysics Data System (ADS)

    Wu, J. W.; Xia, H. M.; Zhang, Y. Y.; Zhu, P.

    2018-05-01

    Fluid mixing in miniaturized fluidic devices is a challenging task. In this work, the mixing enhancement through oscillatory transverse perturbations coupling with divergent circular chambers is studied. To simplify the design, an autonomous microfluidic oscillator is used to produce the oscillatory flow. It is then applied to four side-channels that intersect with a central channel of constant flow. The mixing performance is tested at high fluid viscosities of up to 16 cP. Results show that the oscillatory flow can cause strong transverse perturbations which effectively enhance the mixing. The influence of a fluidic capacitor in the central channel is also examined, which at low viscosities can intensify the perturbations and further improve the mixing.

  9. A Simplified Approach to Job Analysis. Part 2. The Means of Validation

    ERIC Educational Resources Information Center

    Thomas, D. B.; Costley, J. M.

    1969-01-01

    A representative of the Royal Air Force School of Education and a Field Training Advisor to the Civil Air Transport Industry Training Board continue the description of their simplified approach to job analysis. (LY)

  10. Peristaltic transport and mixing of cytosol through the whole body of Physarum plasmodium.

    PubMed

    Iima, Makoto; Nakagaki, Toshiyuki

    2012-09-01

    We study how the net transport and mixing of chemicals occur in a relatively large amoeba, the true slime mold Physarum polycephalum. The shuttle streaming of the amoeba is characterized by a rhythmic flow of the order of 1 μm/s in which the protoplasm streams back and forth. To explain the experimentally observed transport of chemicals, we formulate a simplified model to consider the mechanism by which net transport can be induced by shuttle (or periodic) motion inside the amoeba. This model is independent from the details of fluid property as it is based on the mass conservation law only. Even in such a simplified model, we demonstrate that sectional oscillations play an important role in net transport and discuss the effects of the sectional boundary motion on net transport in the microorganism.

  11. Microfluidic magnetic fluidized bed for DNA analysis in continuous flow mode.

    PubMed

    Hernández-Neuta, Iván; Pereiro, Iago; Ahlford, Annika; Ferraro, Davide; Zhang, Qiongdi; Viovy, Jean-Louis; Descroix, Stéphanie; Nilsson, Mats

    2018-04-15

    Magnetic solid phase substrates for biomolecule manipulation have become a valuable tool for simplification and automation of molecular biology protocols. However, the handling of magnetic particles inside microfluidic chips for miniaturized assays is often challenging due to inefficient mixing, aggregation, and the advanced instrumentation required for effective actuation. Here, we describe the use of a microfluidic magnetic fluidized bed approach that enables dynamic, highly efficient and simplified magnetic bead actuation for DNA analysis in a continuous flow platform with minimal technical requirements. We evaluate the performance of this approach by testing the efficiency of individual steps of a DNA assay based on padlock probes and rolling circle amplification. This assay comprises common nucleic acid analysis principles, such as hybridization, ligation, amplification and restriction digestion. We obtained efficiencies of up to 90% for these reactions with high throughput processing up to 120μL of DNA dilution at flow rates ranging from 1 to 5μL/min without compromising performance. The fluidized bed was 20-50% more efficient than a commercially available solution for microfluidic manipulation of magnetic beads. Moreover, to demonstrate the potential of this approach for integration into micro-total analysis systems, we optimized the production of a low-cost polymer based microarray and tested its analytical performance for integrated single-molecule digital read-out. Finally, we provide the proof-of-concept for a single-chamber microfluidic chip that combines the fluidized bed with the polymer microarray for a highly simplified and integrated magnetic bead-based DNA analyzer, with potential applications in diagnostics. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Dry forests and wildland fires of the inland Northwest USA: contrasting the landscape ecology of the pre-settlement and modern eras.

    Treesearch

    Paul F. Hessburg; James K. Agee; Jerry F. Franklin

    2005-01-01

    Prior to Euro-American settlement, dry ponderosa pine and mixed conifer forests (hereafter, the "dry forests") of the Inland Northwest were burned by frequent low- or mixed-severity fires. These mostly surface fires maintained low and variable tree densities, light and patchy ground fuels, simplified forest structure, and favored fire-tolerant trees, such as...

  13. Easy-to-learn cardiopulmonary resuscitation training programme: a randomised controlled trial on laypeople’s resuscitation performance

    PubMed Central

    Ko, Rachel Jia Min; Lim, Swee Han; Wu, Vivien Xi; Leong, Tak Yam; Liaw, Sok Ying

    2018-01-01

    INTRODUCTION Simplifying the learning of cardiopulmonary resuscitation (CPR) is advocated to improve skill acquisition and retention. A simplified CPR training programme focusing on continuous chest compression, with a simple landmark tracing technique, was introduced to laypeople. The study aimed to examine the effectiveness of the simplified CPR training in improving lay rescuers’ CPR performance as compared to standard CPR. METHODS A total of 85 laypeople (aged 21–60 years) were recruited and randomly assigned to undertake either a two-hour simplified or standard CPR training session. They were tested two months after the training on a simulated cardiac arrest scenario. Participants’ performance on the sequence of CPR steps was observed and evaluated using a validated CPR algorithm checklist. The quality of chest compression and ventilation was assessed from the recording manikins. RESULTS The simplified CPR group performed significantly better on the CPR algorithm when compared to the standard CPR group (p < 0.01). No significant difference was found between the groups in time taken to initiate CPR. However, a significantly higher number of compressions and proportion of adequate compressions was demonstrated by the simplified group than the standard group (p < 0.01). Hands-off time was significantly shorter in the simplified CPR group than in the standard CPR group (p < 0.001). CONCLUSION Simplifying the learning of CPR by focusing on continuous chest compressions, with simple hand placement for chest compression, could lead to better acquisition and retention of CPR algorithms, and better quality of chest compressions than standard CPR. PMID:29167910

  14. Easy-to-learn cardiopulmonary resuscitation training programme: a randomised controlled trial on laypeople's resuscitation performance.

    PubMed

    Ko, Rachel Jia Min; Lim, Swee Han; Wu, Vivien Xi; Leong, Tak Yam; Liaw, Sok Ying

    2018-04-01

    Simplifying the learning of cardiopulmonary resuscitation (CPR) is advocated to improve skill acquisition and retention. A simplified CPR training programme focusing on continuous chest compression, with a simple landmark tracing technique, was introduced to laypeople. The study aimed to examine the effectiveness of the simplified CPR training in improving lay rescuers' CPR performance as compared to standard CPR. A total of 85 laypeople (aged 21-60 years) were recruited and randomly assigned to undertake either a two-hour simplified or standard CPR training session. They were tested two months after the training on a simulated cardiac arrest scenario. Participants' performance on the sequence of CPR steps was observed and evaluated using a validated CPR algorithm checklist. The quality of chest compression and ventilation was assessed from the recording manikins. The simplified CPR group performed significantly better on the CPR algorithm when compared to the standard CPR group (p < 0.01). No significant difference was found between the groups in time taken to initiate CPR. However, a significantly higher number of compressions and proportion of adequate compressions was demonstrated by the simplified group than the standard group (p < 0.01). Hands-off time was significantly shorter in the simplified CPR group than in the standard CPR group (p < 0.001). Simplifying the learning of CPR by focusing on continuous chest compressions, with simple hand placement for chest compression, could lead to better acquisition and retention of CPR algorithms, and better quality of chest compressions than standard CPR. Copyright: © Singapore Medical Association.

  15. The influence of wind-tunnel walls on discrete frequency noise

    NASA Technical Reports Server (NTRS)

    Mosher, M.

    1984-01-01

    This paper describes an analytical model that can be used to examine the effects of wind-tunnel walls on discrete frequency noise. First, a complete physical model of an acoustic source in a wind tunnel is described, and a simplified version is then developed. This simplified model retains the important physical processes involved, yet it is more amenable to analysis. Second, the simplified physical model is formulated as a mathematical problem. An inhomogeneous partial differential equation with mixed boundary conditions is set up and then transformed into an integral equation. The integral equation has been solved with a panel program on a computer. Preliminary results from a simple model problem will be shown and compared with the approximate analytic solution.

  16. A multifluid model extended for strong temperature nonequilibrium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chang, Chong

    2016-08-08

    We present a multifluid model in which the material temperature is strongly affected by the degree of segregation of each material. In order to track temperatures of segregated form and mixed form of the same material, they are defined as different materials with their own energy. This extension makes it necessary to extend multifluid models to the case in which each form is defined as a separate material. Statistical variations associated with the morphology of the mixture have to be simplified. Simplifications introduced include combining all molecularly mixed species into a single composite material, which is treated as another segregatedmore » material. Relative motion within the composite material, diffusion, is represented by material velocity of each component in the composite material. Compression work, momentum and energy exchange, virtual mass forces, and dissipation of the unresolved kinetic energy have been generalized to the heterogeneous mixture in temperature nonequilibrium. The present model can be further simplified by combining all mixed forms of materials into a composite material. Molecular diffusion in this case is modeled by the Stefan-Maxwell equations.« less

  17. Enhanced H-filter based on Fåhræus-Lindqvist effect for efficient and robust dialysis without membrane

    PubMed Central

    Zheng, Wei-Chao; Xie, Rui; He, Li-Qun; Xi, Yue-Heng; Liu, Ying-Mei; Meng, Zhi-Jun; Wang, Wei; Ju, Xiao-Jie; Chen, Gang; Chu, Liang-Yin

    2015-01-01

    A novel microfluidic device for highly efficient and robust dialysis without membrane is highly desired for the development of portable or wearable microdialyzer. Here we report an enhanced H-filter with pillar array based on Fåhræus-Lindqvist effect (F-L effect) for highly efficient and robust membraneless dialysis of simplified blood for the first time. The H-filter employs two fluids laminarly flowing in the microchannel for continuously membraneless dialysis. With pillar array in the microchannel, the two laminar flows, with one containing blood cells and small molecules and another containing dialyzate solution, can form a cell-free layer at the interface as selective zones for separation. This provides enhanced mixing yet extremely low shear for extraction of small molecules from the blood-cell-containing flow into the dialyzate flow, resulting in robust separation with reduced cell loss and improved efficiency. We demonstrate this by first using Chlorella pyrenoidosa as model cells to quantitatively study the separation performances, and then using simplified human blood for dialysis. The advanced H-filter, with highly efficient and robust performance for membraneless dialysis, shows great potential as promising candidate for rapid blood analysis/separation, and as fundamental structure for portable dialyzer. PMID:26339313

  18. Enhanced H-filter based on Fåhræus-Lindqvist effect for efficient and robust dialysis without membrane.

    PubMed

    Zheng, Wei-Chao; Xie, Rui; He, Li-Qun; Xi, Yue-Heng; Liu, Ying-Mei; Meng, Zhi-Jun; Wang, Wei; Ju, Xiao-Jie; Chen, Gang; Chu, Liang-Yin

    2015-07-01

    A novel microfluidic device for highly efficient and robust dialysis without membrane is highly desired for the development of portable or wearable microdialyzer. Here we report an enhanced H-filter with pillar array based on Fåhræus-Lindqvist effect (F-L effect) for highly efficient and robust membraneless dialysis of simplified blood for the first time. The H-filter employs two fluids laminarly flowing in the microchannel for continuously membraneless dialysis. With pillar array in the microchannel, the two laminar flows, with one containing blood cells and small molecules and another containing dialyzate solution, can form a cell-free layer at the interface as selective zones for separation. This provides enhanced mixing yet extremely low shear for extraction of small molecules from the blood-cell-containing flow into the dialyzate flow, resulting in robust separation with reduced cell loss and improved efficiency. We demonstrate this by first using Chlorella pyrenoidosa as model cells to quantitatively study the separation performances, and then using simplified human blood for dialysis. The advanced H-filter, with highly efficient and robust performance for membraneless dialysis, shows great potential as promising candidate for rapid blood analysis/separation, and as fundamental structure for portable dialyzer.

  19. Mixed monofunctional extractants for trivalent actinide/lanthanide separations: TALSPEAK-MME

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johnson, Aaron T.; Nash, Kenneth L.

    The basic features of an f-element extraction process based on a solvent composed of equimolar mixtures of Cyanex-923 (a mixed trialkyl phosphine oxide) and 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) extractants in n-dodecane are investigated in this report. This system, which combines features of the TRPO and TALSPEAK processes, is based on co-extraction of trivalent lanthanides and actinides from 0.1 to 1.0 M HNO 3 followed by application of a buffered aminopolycarboxylate solution strip to accomplish a Reverse TALSPEAK selective removal of actinides. This mixed-extractant medium could enable a simplified approach to selective trivalent f-element extraction and actinide partitioning in amore » single process. As compared with other combined process applications in development for more compact actinide partitioning processes (DIAMEX-SANEX, GANEX, TRUSPEAK, ALSEP), this combination features only monofunctional extractants with high solubility limits and comparatively low molar mass. Selective actinide stripping from the loaded extractant phase is done using a glycine-buffered solution containing N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) or triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid (TTHA). Lastly, the results reported provide evidence for simplified interactions between the two extractants and demonstrate a pathway toward using mixed monofunctional extractants to separate trivalent actinides (An) from fission product lanthanides (Ln).« less

  20. Mixed monofunctional extractants for trivalent actinide/lanthanide separations: TALSPEAK-MME

    DOE PAGES

    Johnson, Aaron T.; Nash, Kenneth L.

    2015-08-20

    The basic features of an f-element extraction process based on a solvent composed of equimolar mixtures of Cyanex-923 (a mixed trialkyl phosphine oxide) and 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (HEH[EHP]) extractants in n-dodecane are investigated in this report. This system, which combines features of the TRPO and TALSPEAK processes, is based on co-extraction of trivalent lanthanides and actinides from 0.1 to 1.0 M HNO 3 followed by application of a buffered aminopolycarboxylate solution strip to accomplish a Reverse TALSPEAK selective removal of actinides. This mixed-extractant medium could enable a simplified approach to selective trivalent f-element extraction and actinide partitioning in amore » single process. As compared with other combined process applications in development for more compact actinide partitioning processes (DIAMEX-SANEX, GANEX, TRUSPEAK, ALSEP), this combination features only monofunctional extractants with high solubility limits and comparatively low molar mass. Selective actinide stripping from the loaded extractant phase is done using a glycine-buffered solution containing N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) or triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetic acid (TTHA). Lastly, the results reported provide evidence for simplified interactions between the two extractants and demonstrate a pathway toward using mixed monofunctional extractants to separate trivalent actinides (An) from fission product lanthanides (Ln).« less

  1. Simplified approach to the mixed time-averaging semiclassical initial value representation for the calculation of dense vibrational spectra

    NASA Astrophysics Data System (ADS)

    Buchholz, Max; Grossmann, Frank; Ceotto, Michele

    2018-03-01

    We present and test an approximate method for the semiclassical calculation of vibrational spectra. The approach is based on the mixed time-averaging semiclassical initial value representation method, which is simplified to a form that contains a filter to remove contributions from approximately harmonic environmental degrees of freedom. This filter comes at no additional numerical cost, and it has no negative effect on the accuracy of peaks from the anharmonic system of interest. The method is successfully tested for a model Hamiltonian and then applied to the study of the frequency shift of iodine in a krypton matrix. Using a hierarchic model with up to 108 normal modes included in the calculation, we show how the dynamical interaction between iodine and krypton yields results for the lowest excited iodine peaks that reproduce experimental findings to a high degree of accuracy.

  2. 7 CFR 273.25 - Simplified Food Stamp Program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 4 2014-01-01 2014-01-01 false Simplified Food Stamp Program. 273.25 Section 273.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS Program Alternatives...

  3. 7 CFR 273.25 - Simplified Food Stamp Program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 4 2012-01-01 2012-01-01 false Simplified Food Stamp Program. 273.25 Section 273.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS Program Alternatives...

  4. 7 CFR 273.25 - Simplified Food Stamp Program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Simplified Food Stamp Program. 273.25 Section 273.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS Program Alternatives...

  5. 7 CFR 273.25 - Simplified Food Stamp Program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Simplified Food Stamp Program. 273.25 Section 273.25 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS Program Alternatives...

  6. Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(-) Ketamine Concentrations.

    PubMed

    Henthorn, Thomas K; Avram, Michael J; Dahan, Albert; Gustafsson, Lars L; Persson, Jan; Krejcie, Tom C; Olofsen, Erik

    2018-05-16

    The pharmacokinetics of infused drugs have been modeled without regard for recirculatory or mixing kinetics. We used a unique ketamine dataset with simultaneous arterial and venous blood sampling, during and after separate S(+) and R(-) ketamine infusions, to develop a simplified recirculatory model of arterial and venous plasma drug concentrations. S(+) or R(-) ketamine was infused over 30 min on two occasions to 10 healthy male volunteers. Frequent, simultaneous arterial and forearm venous blood samples were obtained for up to 11 h. A multicompartmental pharmacokinetic model with front-end arterial mixing and venous blood components was developed using nonlinear mixed effects analyses. A three-compartment base pharmacokinetic model with additional arterial mixing and arm venous compartments and with shared S(+)/R(-) distribution kinetics proved superior to standard compartmental modeling approaches. Total pharmacokinetic flow was estimated to be 7.59 ± 0.36 l/min (mean ± standard error of the estimate), and S(+) and R(-) elimination clearances were 1.23 ± 0.04 and 1.06 ± 0.03 l/min, respectively. The arm-tissue link rate constant was 0.18 ± 0.01 min and the fraction of arm blood flow estimated to exchange with arm tissue was 0.04 ± 0.01. Arterial drug concentrations measured during drug infusion have two kinetically distinct components: partially or lung-mixed drug and fully mixed-recirculated drug. Front-end kinetics suggest the partially mixed concentration is proportional to the ratio of infusion rate and total pharmacokinetic flow. This simplified modeling approach could lead to more generalizable models for target-controlled infusions and improved methods for analyzing pharmacokinetic-pharmacodynamic data.

  7. Development of a design methodology for asphalt treated mixtures.

    DOT National Transportation Integrated Search

    2013-12-01

    This report summarizes the results of a study that was conducted to develop a simplified design methodology for asphalt : treated mixtures that are durable, stable, constructible, and cost effective through the examination of the performance of : mix...

  8. 29 CFR 2200.203 - Commencing Simplified Proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....203 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION... Proceedings, the times for filing a complaint or answer will not run. If a request for Simplified Proceedings is denied, the period for filing a complaint or answer will begin to run upon issuance of the notice...

  9. 29 CFR 2200.203 - Commencing Simplified Proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....203 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION... Proceedings, the times for filing a complaint or answer will not run. If a request for Simplified Proceedings is denied, the period for filing a complaint or answer will begin to run upon issuance of the notice...

  10. Gasdynamic model of turbulent combustion in an explosion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kuhl, A.L.; Ferguson, R.E.; Chien, K.Y.

    1994-08-31

    Proposed here is a gasdynamic model of turbulent combustion in explosions. It is used to investigate turbulent mixing aspects of afterburning found in TNT charges detonated in air. Evolution of the turbulent velocity field was calculated by a high-order Godunov solution of the gasdynamic equations. Adaptive Mesh Refinement (AMR) was used to follow convective-mixing processes on the computational grid. Combustion was then taken into account by a simplified sub-grid model, demonstrating that it was controlled by turbulent mixing. The rate of fuel consumption decayed inversely with time, and was shown to be insensitive to grid resolution.

  11. Representation of Arctic mixed-phase clouds and the Wegener-Bergeron-Findeisen process in climate models: Perspectives from a cloud-resolving study

    NASA Astrophysics Data System (ADS)

    Fan, Jiwen; Ghan, Steven; Ovchinnikov, Mikhail; Liu, Xiaohong; Rasch, Philip J.; Korolev, Alexei

    2011-01-01

    Two types of Arctic mixed-phase clouds observed during the ISDAC and M-PACE field campaigns are simulated using a 3-dimensional cloud-resolving model (CRM) with size-resolved cloud microphysics. The modeled cloud properties agree reasonably well with aircraft measurements and surface-based retrievals. Cloud properties such as the probability density function (PDF) of vertical velocity (w), cloud liquid and ice, regimes of cloud particle growth, including the Wegener-Bergeron-Findeisen (WBF) process, and the relationships among properties/processes in mixed-phase clouds are examined to gain insights for improving their representation in General Circulation Models (GCMs). The PDF of the simulated w is well represented by a Gaussian function, validating, at least for arctic clouds, the subgrid treatment used in GCMs. The PDFs of liquid and ice water contents can be approximated by Gamma functions, and a Gaussian function can describe the total water distribution, but a fixed variance assumption should be avoided in both cases. The CRM results support the assumption frequently used in GCMs that mixed phase clouds maintain water vapor near liquid saturation. Thus, ice continues to grow throughout the stratiform cloud but the WBF process occurs in about 50% of cloud volume where liquid and ice co-exist, predominantly in downdrafts. In updrafts, liquid and ice particles grow simultaneously. The relationship between the ice depositional growth rate and cloud ice strongly depends on the capacitance of ice particles. The simplified size-independent capacitance of ice particles used in GCMs could lead to large deviations in ice depositional growth.

  12. A Simplified Model for Detonation Based Pressure-Gain Combustors

    NASA Technical Reports Server (NTRS)

    Paxson, Daniel E.

    2010-01-01

    A time-dependent model is presented which simulates the essential physics of a detonative or otherwise constant volume, pressure-gain combustor for gas turbine applications. The model utilizes simple, global thermodynamic relations to determine an assumed instantaneous and uniform post-combustion state in one of many envisioned tubes comprising the device. A simple, second order, non-upwinding computational fluid dynamic algorithm is then used to compute the (continuous) flowfield properties during the blowdown and refill stages of the periodic cycle which each tube undergoes. The exhausted flow is averaged to provide mixed total pressure and enthalpy which may be used as a cycle performance metric for benefits analysis. The simplicity of the model allows for nearly instantaneous results when implemented on a personal computer. The results compare favorably with higher resolution numerical codes which are more difficult to configure, and more time consuming to operate.

  13. Simplified models for Higgs physics: singlet scalar and vector-like quark phenomenology

    DOE PAGES

    Dolan, Matthew J.; Hewett, J. L.; Krämer, M.; ...

    2016-07-08

    Simplified models provide a useful tool to conduct the search and exploration of physics beyond the Standard Model in a model-independent fashion. In this study, we consider the complementarity of indirect searches for new physics in Higgs couplings and distributions with direct searches for new particles, using a simplified model which includes a new singlet scalar resonance and vector-like fermions that can mix with the SM top-quark. We fit this model to the combined ATLAS and CMS 125 GeV Higgs production and coupling measurements and other precision electroweak constraints, and explore in detail the effects of the new matter contentmore » upon Higgs production and kinematics. Finally, we highlight some novel features and decay modes of the top partner phenomenology, and discuss prospects for Run II.« less

  14. Predicting Flowering Behavior and Exploring Its Genetic Determinism in an Apple Multi-family Population Based on Statistical Indices and Simplified Phenotyping.

    PubMed

    Durand, Jean-Baptiste; Allard, Alix; Guitton, Baptiste; van de Weg, Eric; Bink, Marco C A M; Costes, Evelyne

    2017-01-01

    Irregular flowering over years is commonly observed in fruit trees. The early prediction of tree behavior is highly desirable in breeding programmes. This study aims at performing such predictions, combining simplified phenotyping and statistics methods. Sequences of vegetative vs. floral annual shoots (AS) were observed along axes in trees belonging to five apple related full-sib families. Sequences were analyzed using Markovian and linear mixed models including year and site effects. Indices of flowering irregularity, periodicity and synchronicity were estimated, at tree and axis scales. They were used to predict tree behavior and detect QTL with a Bayesian pedigree-based analysis, using an integrated genetic map containing 6,849 SNPs. The combination of a Biennial Bearing Index (BBI) with an autoregressive coefficient (γ g ) efficiently predicted and classified the genotype behaviors, despite few misclassifications. Four QTLs common to BBIs and γ g and one for synchronicity were highlighted and revealed the complex genetic architecture of the traits. Irregularity resulted from high AS synchronism, whereas regularity resulted from either asynchronous locally alternating or continual regular AS flowering. A relevant and time-saving method, based on a posteriori sampling of axes and statistical indices is proposed, which is efficient to evaluate the tree breeding values for flowering regularity and could be transferred to other species.

  15. Two extreme types of mixing of dust with urban aerosols observed in Kosa particles: ‘After’ mixing and ‘on-the-way’ mixing

    NASA Astrophysics Data System (ADS)

    Suzuki, Issei; Igarashi, Yasuhito; Dokiya, Yukiko; Akagi, Tasuku

    2010-02-01

    Besides well-known episodic Kosa during spring, high concentrations of Ca 2+ in aerosols were observed early in summer as well as in the semi-continuous data of the aerosols at the summit of Mt. Fuji. We further analysed the data to study the chemical characteristics of the high calcium event during early summer. The back trajectory analyses of the event indicated that Ca was transported from arid and semi-arid regions (e.g. the Taklamakan desert) through the westerly-dominated troposphere higher than the height of the summit of Fuji. The amount of SO 42- was always equivalent to that of NH 4+ unlike the case of the normal Kosa period where SO 42- is in excess with respect to NH 4+. This shows the 'after' mixing of unreacted CaCO 3 of Kosa origin with (NH 4) 2SO 4, which was only realized by the downward injection of Kosa particles from higher altitudes to the air masses of different origin. In the case of normal Kosa, the air bearing Kosa particles passed through the polluted area to absorb unneutralized acids ('on-the-way' mixing), whereas in the case of the Kosa-like phenomena in summer, the acids from the polluted area have been neutralized by NH 4+ and become inactive before mixing with CaCO 3 ("after" mixing). We have simplified the chemistry of aerosols using their three major components, Ca 2+, SO 42- and NH 4+, and introduced a new triangle diagram with the three assumed end-members of CaCO 3, CaSO 4 and (NH 4) 2SO 4 to quantify the contribution of the 'after' mixing to the aerosols (AMI; 'after' mixing index). Based on the back trajectories of some high AMI cases, CaCO 3 in Kosa particles was transported through the middle troposphere (5000-7000 m) and descended to meet another air mass where SO 42- had been already neutralized by NH 3.

  16. Criteria for personal dosimetry in mixed radiation fields in space. [analyzing trapped protons, tissue disintegration stars, and neutrons

    NASA Technical Reports Server (NTRS)

    Schaefer, H. J.

    1974-01-01

    The complexity of direct reading and passive dosimeters for monitoring radiation is studied to strike the right balance of compromise to simplify the monitoring procedure. Trapped protons, tissue disintegration stars, and neutrons are analyzed.

  17. Research study on stabilization and control: Modern sampled-data control theory. Continuous and discrete describing function analysis of the LST system. [with emphasis on the control moment gyroscope control loop

    NASA Technical Reports Server (NTRS)

    Kuo, B. C.; Singh, G.

    1974-01-01

    The dynamics of the Large Space Telescope (LST) control system were studied in order to arrive at a simplified model for computer simulation without loss of accuracy. The frictional nonlinearity of the Control Moment Gyroscope (CMG) Control Loop was analyzed in a model to obtain data for the following: (1) a continuous describing function for the gimbal friction nonlinearity; (2) a describing function of the CMG nonlinearity using an analytical torque equation; and (3) the discrete describing function and function plots for CMG functional linearity. Preliminary computer simulations are shown for the simplified LST system, first without, and then with analytical torque expressions. Transfer functions of the sampled-data LST system are also described. A final computer simulation is presented which uses elements of the simplified sampled-data LST system with analytical CMG frictional torque expressions.

  18. Managing malocclusion in the mixed dentition: six keys to success. Part 1.

    PubMed

    Fleming, Padhraig S; Johal, Ama; DiBiase, Andrew T

    2008-11-01

    Indications of developing malocclusion are often present in the mixed dentition.With judicious supervision and timely intervention their effects can be minimized. The general dental practitioner is ideally placed to recognize, manage and correct many such incipient problems. This first of two papers considers three keys to success involving, normal dental development, deviations from normal eruption patterns, crossbite correction and habit cessation. The appropriate management of developing malocclusion may simplify later orthodontic management or indeed make such intervention unnecessary.

  19. Numerical study of terrain-induced mesoscale motions and hydrostatic form drag in a heated, growing mixed layer

    NASA Technical Reports Server (NTRS)

    Deardorff, J. W.; Ueyoshi, K.; Han, Y.-J.

    1984-01-01

    Han et al. (1982) have found in a previous numerical study of terrain-induced mesoscale motions that the orography caused a steady-state flow pattern to occur. The study was concerned with a simplified case in which no surface heating occurred. The present investigation considers an extension of this study to the more realistic case of a heated, growing daytime mixed layer containing horizontal variations of potential temperature as well as velocity. The model is also extended to include three layers above the mixed layer. It is found for a heated, growing mixed layer, that the mesoscale form drag is a thermal-anomaly or buoyancy effect associated with horizontal variations of potential temperature within the layer.

  20. Simplified filtered Smith predictor for MIMO processes with multiple time delays.

    PubMed

    Santos, Tito L M; Torrico, Bismark C; Normey-Rico, Julio E

    2016-11-01

    This paper proposes a simplified tuning strategy for the multivariable filtered Smith predictor. It is shown that offset-free control can be achieved with step references and disturbances regardless of the poles of the primary controller, i.e., integral action is not explicitly required. This strategy reduces the number of design parameters and simplifies tuning procedure because the implicit integrative poles are not considered for design purposes. The simplified approach can be used to design continuous-time or discrete-time controllers. Three case studies are used to illustrate the advantages of the proposed strategy if compared with the standard approach, which is based on the explicit integrative action. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  1. Hypersonic Vehicle Propulsion System Simplified Model Development

    NASA Technical Reports Server (NTRS)

    Stueber, Thomas J.; Raitano, Paul; Le, Dzu K.; Ouzts, Peter

    2007-01-01

    This document addresses the modeling task plan for the hypersonic GN&C GRC team members. The overall propulsion system modeling task plan is a multi-step process and the task plan identified in this document addresses the first steps (short term modeling goals). The procedures and tools produced from this effort will be useful for creating simplified dynamic models applicable to a hypersonic vehicle propulsion system. The document continues with the GRC short term modeling goal. Next, a general description of the desired simplified model is presented along with simulations that are available to varying degrees. The simulations may be available in electronic form (FORTRAN, CFD, MatLab,...) or in paper form in published documents. Finally, roadmaps outlining possible avenues towards realizing simplified model are presented.

  2. Development and evaluation of a simplified superpave IDT testing system for implementation in mix design and control : final report, March 2008.

    DOT National Transportation Integrated Search

    2009-08-01

    Asphalt mixtures designed using modern conventional methods, whether Marshall or Superpave methodologies, fail to address the cracking performance of these mixtures. Research previously conducted at the University of Florida for the Florida Departmen...

  3. Energy and water vapor transport across a simplified cloud-clear air interface

    NASA Astrophysics Data System (ADS)

    Gallana, L.; Di Savino, S.; De Santi, F.; Iovieno, M.; Tordella, D.

    2014-11-01

    We consider a simplified physics of the could interface where condensation, evaporation and radiation are neglected and momentum, thermal energy and water vapor transport is represented in terms of the Boussinesq model coupled to a passive scalar transport equation for the vapor. The interface is modeled as a layer separating two isotropic turbulent regions with different kinetic energy and vapor concentration. In particular, we focus on the small scale part of the inertial range of the atmospheric boundary layer as well as on the dissipative range of scales which are important to the micro-physics of warm clouds. We have numerically investigated stably stratified interfaces by locally perturbing at an initial instant the standard temperature lapse rate at the cloud interface and then observing the temporal evolution of the system. When the buoyancy term becomes of the same order of the inertial one, we observe a spatial redistribution of the kinetic energy which produce a concomitant pit of kinetic energy within the mixing layer. In this situation, the mixing layer contains two interfacial regions with opposite kinetic energy gradient, which in turn produces two intermittent sublayers in the velocity fluctuations field. This changes the structure of the field with respect to the corresponding non-stratified shearless mixing: the communication between the two turbulent region is weak, and the growth of the mixing layer stops. These results are discussed with respect to Large Eddy Simulations data for the Planetary Boundary Layers.

  4. Effective pore-scale dispersion upscaling with a correlated continuous time random walk approach

    NASA Astrophysics Data System (ADS)

    Le Borgne, T.; Bolster, D.; Dentz, M.; de Anna, P.; Tartakovsky, A.

    2011-12-01

    We investigate the upscaling of dispersion from a pore-scale analysis of Lagrangian velocities. A key challenge in the upscaling procedure is to relate the temporal evolution of spreading to the pore-scale velocity field properties. We test the hypothesis that one can represent Lagrangian velocities at the pore scale as a Markov process in space. The resulting effective transport model is a continuous time random walk (CTRW) characterized by a correlated random time increment, here denoted as correlated CTRW. We consider a simplified sinusoidal wavy channel model as well as a more complex heterogeneous pore space. For both systems, the predictions of the correlated CTRW model, with parameters defined from the velocity field properties (both distribution and correlation), are found to be in good agreement with results from direct pore-scale simulations over preasymptotic and asymptotic times. In this framework, the nontrivial dependence of dispersion on the pore boundary fluctuations is shown to be related to the competition between distribution and correlation effects. In particular, explicit inclusion of spatial velocity correlation in the effective CTRW model is found to be important to represent incomplete mixing in the pore throats.

  5. 26 CFR 1.263A-0 - Outline of regulations under section 263A.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Utilities. (O) Repairs and maintenance. (P) Engineering and design costs. (Q) Spoilage. (R) Tools and...) Engineering and design services. (F) Safety engineering services. (v) Accounting method change. (h) Simplified... mixed service costs. (7) Costs allocable to more than one business. (8) De minimis rule. (9) Separate...

  6. 26 CFR 1.263A-0 - Outline of regulations under section 263A.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Utilities. (O) Repairs and maintenance. (P) Engineering and design costs. (Q) Spoilage. (R) Tools and...) Engineering and design services. (F) Safety engineering services. (v) Accounting method change. (h) Simplified... mixed service costs. (7) Costs allocable to more than one business. (8) De minimis rule. (9) Separate...

  7. 26 CFR 1.263A-0 - Outline of regulations under section 263A.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Utilities. (O) Repairs and maintenance. (P) Engineering and design costs. (Q) Spoilage. (R) Tools and...) Engineering and design services. (F) Safety engineering services. (v) Accounting method change. (h) Simplified... mixed service costs. (7) Costs allocable to more than one business. (8) De minimis rule. (9) Separate...

  8. 26 CFR 1.263A-0 - Outline of regulations under section 263A.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Utilities. (O) Repairs and maintenance. (P) Engineering and design costs. (Q) Spoilage. (R) Tools and...) Engineering and design services. (F) Safety engineering services. (v) Accounting method change. (h) Simplified... mixed service costs. (7) Costs allocable to more than one business. (8) De minimis rule. (9) Separate...

  9. Distributed Planning in a Mixed-Initiative Environment: Collaborative Technologies for Network Centric Operations

    DTIC Science & Technology

    2008-10-01

    Agents in the DEEP architecture extend and use the Java Agent Development (JADE) framework. DEEP requires a distributed multi-agent system and a...framework to help simplify the implementation of this system. JADE was chosen because it is fully implemented in Java , and supports these requirements

  10. Approximate analytical solution to diurnal atmospheric boundary-layer growth under well-watered conditions

    USDA-ARS?s Scientific Manuscript database

    The system of governing equations of a simplified slab model of the uniformly-mixed, purely convective, diurnal atmospheric boundary layer (ABL) is shown to allow immediate solutions for the potential temperature and specific humidity as functions of the ABL height and net radiation when expressed i...

  11. Operational Control Procedures for the Activated Sludge Process, Part III-A: Calculation Procedures.

    ERIC Educational Resources Information Center

    West, Alfred W.

    This is the second in a series of documents developed by the National Training and Operational Technology Center describing operational control procedures for the activated sludge process used in wastewater treatment. This document deals exclusively with the calculation procedures, including simplified mixing formulas, aeration tank…

  12. MINOR FLUX ADJUSTMENT NEAR MIXING RATIO EXTREMES FOR SIMPLIFIED YET HIGHLY ACCURATE MONOTONIC CALCULATION OF TRACER ADVECTION. (R827929)

    EPA Science Inventory

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  13. Design and simulation of stratified probability digital receiver with application to the multipath communication

    NASA Technical Reports Server (NTRS)

    Deal, J. H.

    1975-01-01

    One approach to the problem of simplifying complex nonlinear filtering algorithms is through using stratified probability approximations where the continuous probability density functions of certain random variables are represented by discrete mass approximations. This technique is developed in this paper and used to simplify the filtering algorithms developed for the optimum receiver for signals corrupted by both additive and multiplicative noise.

  14. A system using solid ceramic oxygen electrolyte cells to measure oxygen fugacities in gas-mixing systems

    NASA Technical Reports Server (NTRS)

    Williams, R. J.; Mullins, O.

    1976-01-01

    Details are given for the construction and operation of a 101.3 kN/sq m (1 atmosphere) redox control system. A solid ceramic oxygen electrolyte cell is used to monitor the oxygen fugacity in the furnace. The system consists of a vertical quench, gas mixing furnace with heads designed for mounting the electrolyte cell and with facilities for inserting and removing the samples. The system also contains the high input impedance electronics necessary for measurements, a simplified version of a gas mixing apparatus, and devices for experiments under controlled rates of change relative to temperature and redox state. The calibration and maintenance of the system are discussed.

  15. A simplified design of the staggered herringbone micromixer for practical applications

    PubMed Central

    Du, Yan; Zhang, Zhiyi; Yim, ChaeHo; Lin, Min; Cao, Xudong

    2010-01-01

    We demonstrated a simple method for the device design of a staggered herringbone micromixer (SHM) using numerical simulation. By correlating the simulated concentrations with channel length, we obtained a series of concentration versus channel length profiles, and used mixing completion length Lm as the only parameter to evaluate the performance of device structure on mixing. Fluorescence quenching experiments were subsequently conducted to verify the optimized SHM structure for a specific application. Good agreement was found between the optimization and the experimental data. Since Lm is straightforward, easily defined and calculated parameter for characterization of mixing performance, this method for designing micromixers is simple and effective for practical applications. PMID:20697584

  16. A simplified design of the staggered herringbone micromixer for practical applications.

    PubMed

    Du, Yan; Zhang, Zhiyi; Yim, Chaeho; Lin, Min; Cao, Xudong

    2010-05-07

    We demonstrated a simple method for the device design of a staggered herringbone micromixer (SHM) using numerical simulation. By correlating the simulated concentrations with channel length, we obtained a series of concentration versus channel length profiles, and used mixing completion length L(m) as the only parameter to evaluate the performance of device structure on mixing. Fluorescence quenching experiments were subsequently conducted to verify the optimized SHM structure for a specific application. Good agreement was found between the optimization and the experimental data. Since L(m) is straightforward, easily defined and calculated parameter for characterization of mixing performance, this method for designing micromixers is simple and effective for practical applications.

  17. JSC systems using solid ceramic oxygen electrolyte cells to measure oxygen fugacites in gas-mixing systems

    NASA Technical Reports Server (NTRS)

    Williams, R. J.; Mullins, O.

    1981-01-01

    Details are given for the construction and operation of a 101.3 KN/sq meter (1 atmosphere) redox control system. A solid ceramic oxygen electrolyte cell is used to monitor the oxygen fugacity in the furnace. The system consists of a vertical quench gas mixing furnace with heads designed for mounting the electrolyte cell and with facilities for inserting and removing the samples, a simplified version of a gas mixing apparatus, and devices for experiments under controlled rates of change of temperature. A thermogravimetric analysis system employing these techniques of redox control and measurement is also described. The calibration and maintenance of the system are discussed.

  18. Stripped-Down Poker: A Classroom Game with Signaling and Bluffing

    ERIC Educational Resources Information Center

    Reiley, David H.; Urbancic, Michael B.; Walker, Mark

    2008-01-01

    The authors present a simplified, "stripped-down" version of poker as an instructional classroom game. Although Stripped-Down Poker is extremely simple, it nevertheless provides an excellent illustration of a number of topics: signaling, bluffing, mixed strategies, the value of information, and Bayes's Rule. The authors begin with a description of…

  19. Simplifying the circuit of Josephson parametric converters

    NASA Astrophysics Data System (ADS)

    Abdo, Baleegh; Brink, Markus; Chavez-Garcia, Jose; Keefe, George

    Josephson parametric converters (JPCs) are quantum-limited three-wave mixing devices that can play various important roles in quantum information processing in the microwave domain, including amplification of quantum signals, transduction of quantum information, remote entanglement of qubits, nonreciprocal amplification, and circulation of signals. However, the input-output and biasing circuit of a state-of-the-art JPC consists of bulky components, i.e. two commercial off-chip broadband 180-degree hybrids, four phase-matched short coax cables, and one superconducting magnetic coil. Such bulky hardware significantly hinders the integration of JPCs in scalable quantum computing architectures. In my talk, I will present ideas on how to simplify the JPC circuit and show preliminary experimental results

  20. Using probabilistic theory to develop interpretation guidelines for Y-STR profiles.

    PubMed

    Taylor, Duncan; Bright, Jo-Anne; Buckleton, John

    2016-03-01

    Y-STR profiling makes up a small but important proportion of forensic DNA casework. Often Y-STR profiles are used when autosomal profiling has failed to yield an informative result. Consequently Y-STR profiles are often from the most challenging samples. In addition to these points, Y-STR loci are linked, meaning that evaluation of haplotype probabilities are either based on overly simplified counting methods or computationally costly genetic models, neither of which extend well to the evaluation of mixed Y-STR data. For all of these reasons Y-STR data analysis has not seen the same advances as autosomal STR data. We present here a probabilistic model for the interpretation of Y-STR data. Due to the fact that probabilistic systems for Y-STR data are still some way from reaching active casework, we also describe how data can be analysed in a continuous way to generate interpretational thresholds and guidelines. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. Hybrid micro-particles as a magnetically-guidable decontaminant for cesium-eluted ash slurry

    NASA Astrophysics Data System (ADS)

    Namiki, Yoshihisa; Ueyama, Toshihiko; Yoshida, Takayuki; Watanabe, Ryoei; Koido, Shigeo; Namiki, Tamami

    2014-09-01

    Decontamination of the radioactive cesium that is widely dispersed owing to a nuclear power station accident and concentrated in fly ash requires an effective elimination system. Radioactive fly ash contains large amounts of water-soluble cesium that can cause severe secondary contamination and represents a serious health risk, yet its complete removal is complicated and difficult. Here it is shown that a new fine-powder formulation can be magnetically guided to eliminate cesium after being mixed with the ash slurry. This formulation, termed MagCE, consists of a ferromagnetic porous structure and alkaline- and salt-resistant nickel ferrocyanide. It has potent cesium-adsorption- and magnetic-separation-properties. Because of its resistance against physical and chemical attack such as with ash particles, as well as with the high pH and salt concentration of the ash slurry, MagCE simplifies the decontamination process without the need of the continued presence of the hazardous water-soluble cesium in the treated ash.

  2. Hybrid micro-particles as a magnetically-guidable decontaminant for cesium-eluted ash slurry

    PubMed Central

    Namiki, Yoshihisa; Ueyama, Toshihiko; Yoshida, Takayuki; Watanabe, Ryoei; Koido, Shigeo; Namiki, Tamami

    2014-01-01

    Decontamination of the radioactive cesium that is widely dispersed owing to a nuclear power station accident and concentrated in fly ash requires an effective elimination system. Radioactive fly ash contains large amounts of water-soluble cesium that can cause severe secondary contamination and represents a serious health risk, yet its complete removal is complicated and difficult. Here it is shown that a new fine-powder formulation can be magnetically guided to eliminate cesium after being mixed with the ash slurry. This formulation, termed MagCE, consists of a ferromagnetic porous structure and alkaline- and salt-resistant nickel ferrocyanide. It has potent cesium-adsorption- and magnetic-separation-properties. Because of its resistance against physical and chemical attack such as with ash particles, as well as with the high pH and salt concentration of the ash slurry, MagCE simplifies the decontamination process without the need of the continued presence of the hazardous water-soluble cesium in the treated ash. PMID:25192495

  3. Hybrid micro-particles as a magnetically-guidable decontaminant for cesium-eluted ash slurry.

    PubMed

    Namiki, Yoshihisa; Ueyama, Toshihiko; Yoshida, Takayuki; Watanabe, Ryoei; Koido, Shigeo; Namiki, Tamami

    2014-09-05

    Decontamination of the radioactive cesium that is widely dispersed owing to a nuclear power station accident and concentrated in fly ash requires an effective elimination system. Radioactive fly ash contains large amounts of water-soluble cesium that can cause severe secondary contamination and represents a serious health risk, yet its complete removal is complicated and difficult. Here it is shown that a new fine-powder formulation can be magnetically guided to eliminate cesium after being mixed with the ash slurry. This formulation, termed MagCE, consists of a ferromagnetic porous structure and alkaline- and salt-resistant nickel ferrocyanide. It has potent cesium-adsorption- and magnetic-separation-properties. Because of its resistance against physical and chemical attack such as with ash particles, as well as with the high pH and salt concentration of the ash slurry, MagCE simplifies the decontamination process without the need of the continued presence of the hazardous water-soluble cesium in the treated ash.

  4. PLC based automatic control of pasteurize mix in ice cream production

    NASA Astrophysics Data System (ADS)

    Yao, Xudong; Liang, Kai

    2013-03-01

    This paper describes the automatic control device of pasteurized mix in the ice cream production process.We design a scheme of control system using FBD program language and develop the programmer in the STEP 7-Micro/WIN software, check for any bugs before downloading into PLC .These developed devices will able to provide flexibility and accuracy to control the step of pasteurized mix. The operator just Input the duration and temperature of pasteurized mix through control panel. All the steps will finish automatically without any intervention in a preprogrammed sequence stored in programmable logic controller (PLC). With the help of this equipment we not only can control the quality of ice cream for various conditions, but also can simplify the production process. This control system is inexpensive and can be widely used in ice cream production industry.

  5. Estimation of effective population size in continuously distributed populations: There goes the neighborhood

    Treesearch

    M. C. Neel; K. McKelvey; N. Ryman; M. W. Lloyd; R. Short Bull; F. W. Allendorf; M. K. Schwartz; R. S. Waples

    2013-01-01

    Use of genetic methods to estimate effective population size (Ne) is rapidly increasing, but all approaches make simplifying assumptions unlikely to be met in real populations. In particular, all assume a single, unstructured population, and none has been evaluated for use with continuously distributed species. We simulated continuous populations with local mating...

  6. DEVELOPMENT OF A MODEL FOR REAL TIME CO CONCENTRATIONS NEAR ROADWAYS

    EPA Science Inventory

    Although emission standards for mobile sources continue to be tightened, tailpipe emissions in urban areas continue to be a major source of human exposure to air toxics. Current human exposure models using simplified assumptions based on fixed air monitoring stations and region...

  7. Stained-Glass Pastels

    ERIC Educational Resources Information Center

    Laird, Shirley

    2009-01-01

    The author has always liked the look of stained-glass windows. Usually the designs are simplified and the shapes are easier for younger students to draw. This technique seemed to be the perfect place for her fifth-graders to try their hand at color mixing. The smaller spaces and simple shapes were just what she needed for this group. Her students…

  8. Probabilistic Gait Classification in Children with Cerebral Palsy: A Bayesian Approach

    ERIC Educational Resources Information Center

    Van Gestel, Leen; De Laet, Tinne; Di Lello, Enrico; Bruyninckx, Herman; Molenaers, Guy; Van Campenhout, Anja; Aertbelien, Erwin; Schwartz, Mike; Wambacq, Hans; De Cock, Paul; Desloovere, Kaat

    2011-01-01

    Three-dimensional gait analysis (3DGA) generates a wealth of highly variable data. Gait classifications help to reduce, simplify and interpret this vast amount of 3DGA data and thereby assist and facilitate clinical decision making in the treatment of CP. CP gait is often a mix of several clinically accepted distinct gait patterns. Therefore,…

  9. A Comparative Study of Language Reforms in China and Japan. Skidmore College Faculty Research Lecture 1969.

    ERIC Educational Resources Information Center

    Chu, Yu-Kuang; Nishimoto, Koji

    1969-01-01

    Chinese and Japanese, although they are unrelated languages, nevertheless have similar writing systems, since Japanese writing employs a mixed system of Chinese characters and phonetic script. Because Chinese characters are difficult to learn, however, reform movements to simplify the writing system to make the task of learning easier for a…

  10. A control-volume method for analysis of unsteady thrust augmenting ejector flows

    NASA Technical Reports Server (NTRS)

    Drummond, Colin K.

    1988-01-01

    A method for predicting transient thrust augmenting ejector characteristics is presented. The analysis blends classic self-similar turbulent jet descriptions with a control volume mixing region discretization to solicit transient effects in a new way. Division of the ejector into an inlet, diffuser, and mixing region corresponds with the assumption of viscous-dominated phenomenon in the latter. Inlet and diffuser analyses are simplified by a quasi-steady analysis, justified by the assumptions that pressure is the forcing function in those regions. Details of the theoretical foundation, the solution algorithm, and sample calculations are given.

  11. A continuous mixing model for pdf simulations and its applications to combusting shear flows

    NASA Technical Reports Server (NTRS)

    Hsu, A. T.; Chen, J.-Y.

    1991-01-01

    The problem of time discontinuity (or jump condition) in the coalescence/dispersion (C/D) mixing model is addressed in this work. A C/D mixing model continuous in time is introduced. With the continuous mixing model, the process of chemical reaction can be fully coupled with mixing. In the case of homogeneous turbulence decay, the new model predicts a pdf very close to a Gaussian distribution, with finite higher moments also close to that of a Gaussian distribution. Results from the continuous mixing model are compared with both experimental data and numerical results from conventional C/D models.

  12. Research study on IPS digital controller design

    NASA Technical Reports Server (NTRS)

    Kuo, B. C.; Folkerts, C.

    1976-01-01

    The performance is investigated of the simplified continuous-data model of the Instrument Pointing System (IPS). Although the ultimate objective is to study the digital model of the system, knowledge on the performance of the continuous-data model is important in the sense that the characteristics of the digital system should approach those of the continuous-data system as the sampling period approaches zero.

  13. Efficient construction of unified continuous and discontinuous Galerkin formulations for the 3D Euler equations

    NASA Astrophysics Data System (ADS)

    Abdi, Daniel S.; Giraldo, Francis X.

    2016-09-01

    A unified approach for the numerical solution of the 3D hyperbolic Euler equations using high order methods, namely continuous Galerkin (CG) and discontinuous Galerkin (DG) methods, is presented. First, we examine how classical CG that uses a global storage scheme can be constructed within the DG framework using constraint imposition techniques commonly used in the finite element literature. Then, we implement and test a simplified version in the Non-hydrostatic Unified Model of the Atmosphere (NUMA) for the case of explicit time integration and a diagonal mass matrix. Constructing CG within the DG framework allows CG to benefit from the desirable properties of DG such as, easier hp-refinement, better stability etc. Moreover, this representation allows for regional mixing of CG and DG depending on the flow regime in an area. The different flavors of CG and DG in the unified implementation are then tested for accuracy and performance using a suite of benchmark problems representative of cloud-resolving scale, meso-scale and global-scale atmospheric dynamics. The value of our unified approach is that we are able to show how to carry both CG and DG methods within the same code and also offer a simple recipe for modifying an existing CG code to DG and vice versa.

  14. The role of boundary variability in polycrystalline grain-boundary diffusion

    NASA Astrophysics Data System (ADS)

    Moghadam, M. M.; Rickman, J. M.; Harmer, M. P.; Chan, H. M.

    2015-01-01

    We investigate the impact of grain-boundary variability on mass transport in a polycrystal. More specifically, we perform both numerical and analytical studies of steady-state diffusion in prototypical microstructures in which there is either a discrete spectrum of grain-boundary activation energies or else a complex distribution of grain-boundary character, and hence a continuous spectrum of boundary activation energies. An effective diffusivity is calculated for these structures using simplified multi-state models and, for the case of a continuous spectrum, employing experimentally obtained grain-boundary energy data. We identify different diffusive regimes for these cases and quantify deviations from Arrhenius behavior using effective medium theory. Finally, we examine the diffusion kinetics of a simplified model of an interfacial layering (i.e., complexion) transition.

  15. Versatile composite resins simplifying the practice of restorative dentistry.

    PubMed

    Margeas, Robert

    2014-01-01

    After decades of technical development and refinement, composite resins continue to simplify the practice of restorative dentistry, offering clinicians versatility, predictability, and enhanced physical properties. With a wide range of products available today, composite resins are a reliable, conservative, multi-functional restorative material option. As manufacturers strive to improve such properties as compression strength, flexural strength, elastic modulus, coefficient of thermal expansion, water sorption, and wear resistance, several classification systems of composite resins have been developed.

  16. Simplified pipe gun

    NASA Astrophysics Data System (ADS)

    Sørensen, H.; Nordskov, A.; Sass, B.; Visler, T.

    1987-12-01

    A simplified version of a deuterium pellet gun based on the pipe gun principle is described. The pipe gun is made from a continuous tube of stainless steel and gas is fed in from the muzzle end only. It is indicated that the pellet length is determined by the temperature gradient along the barrel right outside the freezing cell. Velocities of around 1000 m/s with a scatter of ±2% are obtained with a propellant gas pressure of 40 bar.

  17. Development of a global aerosol model using a two-dimensional sectional method: 1. Model design

    NASA Astrophysics Data System (ADS)

    Matsui, H.

    2017-08-01

    This study develops an aerosol module, the Aerosol Two-dimensional bin module for foRmation and Aging Simulation version 2 (ATRAS2), and implements the module into a global climate model, Community Atmosphere Model. The ATRAS2 module uses a two-dimensional (2-D) sectional representation with 12 size bins for particles from 1 nm to 10 μm in dry diameter and 8 black carbon (BC) mixing state bins. The module can explicitly calculate the enhancement of absorption and cloud condensation nuclei activity of BC-containing particles by aging processes. The ATRAS2 module is an extension of a 2-D sectional aerosol module ATRAS used in our previous studies within a framework of a regional three-dimensional model. Compared with ATRAS, the computational cost of the aerosol module is reduced by more than a factor of 10 by simplifying the treatment of aerosol processes and 2-D sectional representation, while maintaining good accuracy of aerosol parameters in the simulations. Aerosol processes are simplified for condensation of sulfate, ammonium, and nitrate, organic aerosol formation, coagulation, and new particle formation processes, and box model simulations show that these simplifications do not substantially change the predicted aerosol number and mass concentrations and their mixing states. The 2-D sectional representation is simplified (the number of advected species is reduced) primarily by the treatment of chemical compositions using two interactive bin representations. The simplifications do not change the accuracy of global aerosol simulations. In part 2, comparisons with measurements and the results focused on aerosol processes such as BC aging processes are shown.

  18. Binary Phase Behavior of Saturated-Unsaturated Mixed-Acid Triacylglycerols-A Review.

    PubMed

    Zhang, Lu; Ueno, Satoru; Sato, Kiyotaka

    2018-06-01

    Most natural lipids contain a complex mixture of individual triacylglycerols (TAGs). An in-depth knowledge of the mixing behavior of TAGs is necessary for the rational design and engineering of food materials. The binary phase diagram of TAGs is a simplified model that can be explored to help foster an understanding of the phase behavior of complex fats and oils. This article reviews recent research on the binary phase behavior of saturated-unsaturated mixed-acid TAGs, with special emphasis on the stearicunsaturated and palmitic-unsaturated diacid TAGs. The occurrence of polymorphic forms and mutual solubility of TAG mixtures are strongly related to the glycerol conformation of the saturated-oleic diacid TAGs; it appears to be most influenced by the chain-length mismatch in saturated-elaidic diacid TAGs. In addition, the polymorphism of pure enantiomers and racemic mixture of chiral TAGs was also reviewed, while the effect of chirality on mixing behavior was discussed.

  19. A microchip laser source with stable intensity and frequency used for self-mixing interferometry.

    PubMed

    Zhang, Shaohui; Zhang, Shulian; Tan, Yidong; Sun, Liqun

    2016-05-01

    We present a stable 40 × 40 × 30 mm(3) Laser-diode (LD)-pumped-microchip laser (ML) laser source used for self-mixing interferometry which can measure non-cooperative targets. We simplify the coupling process of pump light in order to make its polarization and intensity robust against environmental disturbance. Thermal frequency stabilization technology is used to stabilize the laser frequency of both LD and ML. Frequency stability of about 1 × 10(-7) and short-term intensity fluctuation of 0.1% are achieved. The theoretical long-term displacement accuracy limited by frequency and intensity fluctuation is about 10 nm when the measuring range is 0.1 m. The line-width of this laser is about 25 kHz corresponding to 12 km coherent length and 6 km measurement range for self-mixing interference. The laser source has been equipped to a self-mixing interferometer, and it works very well.

  20. (Energetics of silicate melts from thermal diffusion studies)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1989-01-01

    Research during the past year has been concentrated in four major areas. We are continuing work initiated during the first two years on modelling thermal diffusion on multicomponent silicate liquids. We have derived appropriate relations for ternary and quaternary systems and reanalyzed experimental thermal diffusion data for the ternary system fayalite-leucite-silica. In our manuscript entitled Thermal Diffusion in Petrology'', to be published in Adv. in Phy. Geochem., we show that these model results independently recover the compositional extent and temperature of liquid immiscibility in this system. Such retrieval provides a rigorous test of our theoretical predictions and simplified treatment ofmore » complex silicate liquids reported in Geochimica Cosmochimica Acta in 1986. The usefulness of our Soret research in providing mixing energies of silicate liquids has been recently confirmed by Ghiorso (1987, Cont. Min. Pet.). This demonstration provides a strategy for incorporating Soret data into the calibration of phase equilibrium-based solution models such as the one developed by Ghiorso. During the past year we also have resumed our studies of thermal diffusion in borosilicate glasses which also exhibit liquid immiscibility. Our objectives in studying these systems are (1) to further test of our multicomponent thermal diffusion model and (2) to provide quantitative constraints on the mixing properties of these glass-forming systems which are important for evaluating their suitability for storage of high-level nuclear waste. 16 refs.« less

  1. A simplified experimental model for clearance of some pathogenic bacteria using common bacterivorous ciliated spp. in Tigris river

    NASA Astrophysics Data System (ADS)

    Ali, Talib Hassan; Saleh, Dhuha Saad

    2014-03-01

    Bacteria-specific uptake rates of three different protozoan taxa on a pure and mixed bacterial community was studied by means of a simplified and functionally reproducible experimental model. The bacterial species Shigella flexneri, Escherichia coli and Salmonella typhi were isolated and classified from stool samples of patients suffering from diarrhea. Paramecium caudatum, Tetrahymena pyriformis and Halteria grandinella, free living ciliate Protozoans, were isolated and identified from Tigris river water. Pure and mixed ( E. coli + S. typhi), ( E. coli + Sh. flexneri) bacterial cultures were used with each ciliate genera to evaluate the following: predator duplication rate, prey reduction rate, clearance rate and net grazing rate. We used selective lactose fermentation phenomena of enteric bacteria on MacConkey medium for the quantification of bacteria cultural characteristics. The final bacteria concentration was reduced by growing protozoa of 98-99.9 % compared to protozoa-free controls. It showed that Tetrahymena pyriformis had the highest duplication rate (4.13 time/day) in both types of cultures (pure and mixed), followed by Paramecium caudatum and Halteria grandinella, respectively. Paramecium caudatum had the highest rate of ingestion in both types of cultures (26 × 103 bacteria/organism/hr) and yielded the longest time required for 90 % bacterial reduction in a pure suspension of S. typhi (166 h). Clearance rates of pathogenic bacteria by ciliates ranged between 106 nanoliter/organism/h by P. caudatum to S. typhi and 1.92 nanoliter/organism/h seen in T. pyriformis in ( E. coli + S. typhi) mixed culture. We used aquatic experimental microcosms under controlled conditions to explore bacteria-dependent ciliate growth and examined whether these ciliates could discriminate between equally sized bacterial preys in a mixture.

  2. Simplified process for leaching precious metals from fuel cell membrane electrode assemblies

    DOEpatents

    Shore, Lawrence [Edison, NJ; Matlin, Ramail [Berkeley Heights, NJ

    2009-12-22

    The membrane electrode assemblies of fuel cells are recycled to recover the catalyst precious metals from the assemblies. The assemblies are cryogenically embrittled and pulverized to form a powder. The pulverized assemblies are then mixed with a surfactant to form a paste which is contacted with an acid solution to leach precious metals from the pulverized membranes.

  3. Benzene destruction in aqueous waste—I. Bench-scale gamma irradiation experiments

    NASA Astrophysics Data System (ADS)

    Cooper, William J.; Dougal, Roger A.; Nickelsen, Michael G.; Waite, Thomas D.; Kurucz, Charles N.; Lin, Kaijin; Bibler, Jane P.

    1996-07-01

    Destruction of the benzene component of a simulated low-level mixed aqueous waste stream by high energy irradiation was explored. This work was motivated by the fact that mixed waste, containing both radionuclides and regulated (non-radioactive) chemicals, is more difficult and more expensive to dispose of than only radioactive waste. After the benzene is destroyed, the waste can then be listed only as radiological waste instead of mixed waste, simplifying its disposal. This study quantifies the removal of benzene, and the formation and destruction of reaction products in a relatively complex waste stream matrix consisting of NO 3-, SO 42-, PO 43-, Fe 2+ and detergent at a pH of 3. All of the experiments were conducted at a bench scale using a 60Co gamma source.

  4. Dynamically rich, yet parameter-sparse models for spatial epidemiology. Comment on "Coupled disease-behavior dynamics on complex networks: A review" by Z. Wang et al.

    NASA Astrophysics Data System (ADS)

    Jusup, Marko; Iwami, Shingo; Podobnik, Boris; Stanley, H. Eugene

    2015-12-01

    Since the very inception of mathematical modeling in epidemiology, scientists exploited the simplicity ingrained in the assumption of a well-mixed population. For example, perhaps the earliest susceptible-infectious-recovered (SIR) model developed by L. Reed and W.H. Frost in the 1920s [1], included the well-mixed assumption such that any two individuals in the population could meet each other. The problem was that, unlike many other simplifying assumptions used in epidemiological modeling whose validity holds in one situation or the other, well-mixed populations are almost non-existent in reality because the nature of human socio-economic interactions is, for the most part, highly heterogeneous (e.g. [2-6]).

  5. Simplifying the complexity of resistance heterogeneity in metastasis

    PubMed Central

    Lavi, Orit; Greene, James M.; Levy, Doron; Gottesman, Michael M.

    2014-01-01

    The main goal of treatment regimens for metastasis is to control growth rates, not eradicate all cancer cells. Mathematical models offer methodologies that incorporate high-throughput data with dynamic effects on net growth. The ideal approach would simplify, but not over-simplify, a complex problem into meaningful and manageable estimators that predict a patient’s response to specific treatments. Here, we explore three fundamental approaches with different assumptions concerning resistance mechanisms, in which the cells are categorized into either discrete compartments or described by a continuous range of resistance levels. We argue in favor of modeling resistance as a continuum and demonstrate how integrating cellular growth rates, density-dependent versus exponential growth, and intratumoral heterogeneity improves predictions concerning the resistance heterogeneity of metastases. PMID:24491979

  6. Higgs-flavon mixing and LHC phenomenology in a simplified model of broken flavor symmetry [Higgs boson physics and broken flavor symmetry - LHC phenomenology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Berger, Edmond L.; Giddings, Steven B.; Wang, Haichen

    2014-10-10

    Here, the LHC phenomenology of a low-scale gauged flavor symmetry model with inverted hierarchy is studied, through introduction of a simplified model of broken flavor symmetry. A new scalar (a flavon) and a new neutral top-philic massive gauge boson emerge with mass in the TeV range, along with a new heavy fermion associated with the standard model top quark. After checking constraints from electroweak precision observables, we investigate the influence of the model on Higgs boson physics, notably on its production cross section and decay branching fractions. Limits on the flavon φ from heavy Higgs boson searches at the LHCmore » at 7 and 8 TeV are presented. The branching fractions of the flavon are computed as a function of the flavon mass and the Higgs-flavon mixing angle. We also explore possible discovery of the flavon at 14 TeV, particularly via the φ → Z 0Z 0 decay channel in the 2ℓ2ℓ' final state, and through standard model Higgs boson pair production φ → hh in the b¯bγγ final state. We conclude that the flavon mass range up to 500 GeV could be probed down to quite small values of the Higgs-flavon mixing angle with 100 fb –1 of integrated luminosity at 14 TeV.« less

  7. Comparison between a typical and a simplified model for blast load-induced structural response

    NASA Astrophysics Data System (ADS)

    Abd-Elhamed, A.; Mahmoud, S.

    2017-02-01

    As explosive blasts continue to cause severe damage as well as victims in both civil and military environments. There is a bad need for understanding the behavior of structural elements to such extremely short duration dynamic loads where it is of great concern nowadays. Due to the complexity of the typical blast pressure profile model and in order to reduce the modelling and computational efforts, the simplified triangle model for blast loads profile is used to analyze structural response. This simplified model considers only the positive phase and ignores the suction phase which characterizes the typical one in simulating blast loads. The closed from solution for the equation of motion under blast load as a forcing term modelled either typical or simplified models has been derived. The considered herein two approaches have been compared using the obtained results from simulation response analysis of a building structure under an applied blast load. The computed error in simulating response using the simplified model with respect to the typical one has been computed. In general, both simplified and typical models can perform the dynamic blast-load induced response of building structures. However, the simplified one shows a remarkably different response behavior as compared to the typical one despite its simplicity and the use of only positive phase for simulating the explosive loads. The prediction of the dynamic system responses using the simplified model is not satisfactory due to the obtained larger errors as compared to the system responses obtained using the typical one.

  8. Simplified formulations with high drug loads for continuous twin-screw granulation.

    PubMed

    Meier, R; Thommes, M; Rasenack, N; Krumme, M; Moll, K-P; Kleinebudde, P

    2015-12-30

    As different batches of the same excipients will be intermixed during continuous processes, the traceability of batches is complicated. Simplified formulations may help to reduce problems related to batch intermixing and traceability. Twin-screw granulation with subsequent tableting was used to produce granules and tablets, containing drug, disintegrant and binder (binary and ternary mixtures), only. Drug loads up to 90% were achieved and five different disintegrants were screened for keeping their disintegration suitability after wetting. Granule size distributions were consistently mono-modal and narrow. Granule strength reached higher values, using ternary mixtures. Tablets containing croscarmellose-Na as disintegrant displayed tensile strengths up to 3.1MPa and disintegration times from 400 to 466s, resulting in the most robust disintegrant. Dissolution was overall complete and above 96% within 30 min. Na-starch glycolate offers tensile strengths up to 2.8MPa at disintegration times from 25s to 1031s, providing the broadest application window, as it corresponds in some parts to different definitions of orodispersible tablets. Tablets containing micronized crospovidone are not suitable for immediate release, but showed possibilities to produce highly drug loaded, prolonged release tablets. Tablets and granules from simplified formulations offer great opportunities to improve continuous processes, present performances comparable to more complicated formulations and are able to correspond to requirements of the authorities. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. State space approach to mixed boundary value problems.

    NASA Technical Reports Server (NTRS)

    Chen, C. F.; Chen, M. M.

    1973-01-01

    A state-space procedure for the formulation and solution of mixed boundary value problems is established. This procedure is a natural extension of the method used in initial value problems; however, certain special theorems and rules must be developed. The scope of the applications of the approach includes beam, arch, and axisymmetric shell problems in structural analysis, boundary layer problems in fluid mechanics, and eigenvalue problems for deformable bodies. Many classical methods in these fields developed by Holzer, Prohl, Myklestad, Thomson, Love-Meissner, and others can be either simplified or unified under new light shed by the state-variable approach. A beam problem is included as an illustration.

  10. Three-dimensional turbulent-mixing-length modeling for discrete-hole coolant injection into a crossflow

    NASA Technical Reports Server (NTRS)

    Wang, C. R.; Papell, S. S.

    1983-01-01

    Three dimensional mixing length models of a flow field immediately downstream of coolant injection through a discrete circular hole at a 30 deg angle into a crossflow were derived from the measurements of turbulence intensity. To verify their effectiveness, the models were used to estimate the anisotropic turbulent effects in a simplified theoretical and numerical analysis to compute the velocity and temperature fields. With small coolant injection mass flow rate and constant surface temperature, numerical results of the local crossflow streamwise velocity component and surface heat transfer rate are consistent with the velocity measurement and the surface film cooling effectiveness distributions reported in previous studies.

  11. Three-dimensional turbulent-mixing-length modeling for discrete-hole coolant injection into a crossflow

    NASA Astrophysics Data System (ADS)

    Wang, C. R.; Papell, S. S.

    1983-09-01

    Three dimensional mixing length models of a flow field immediately downstream of coolant injection through a discrete circular hole at a 30 deg angle into a crossflow were derived from the measurements of turbulence intensity. To verify their effectiveness, the models were used to estimate the anisotropic turbulent effects in a simplified theoretical and numerical analysis to compute the velocity and temperature fields. With small coolant injection mass flow rate and constant surface temperature, numerical results of the local crossflow streamwise velocity component and surface heat transfer rate are consistent with the velocity measurement and the surface film cooling effectiveness distributions reported in previous studies.

  12. Efficiency gain from elastic optical networks

    NASA Astrophysics Data System (ADS)

    Morea, Annalisa; Rival, Olivier

    2011-12-01

    We compare the cost-efficiency of optical networks based on mixed datarates (10, 40, 100Gb/s) and datarateelastic technologies. A European backbone network is examined under various traffic assumptions (volume of transported data per demand and total number of demands) to better understand the impact of traffic characteristics on cost-efficiency. Network dimensioning is performed for static and restorable networks (resilient to one-link failure). In this paper we will investigate the trade-offs between price of interfaces, reach and reconfigurability, showing that elastic solutions can be more cost-efficient than mixed-rate solutions because of the better compatibility between different datarates, increased reach of channels and simplified wavelength allocation.

  13. A practical method of determining water current velocities and diffusion coefficients in coastal waters by remote sensing techniques

    NASA Technical Reports Server (NTRS)

    James, W. P.

    1971-01-01

    A simplified procedure is presented for determining water current velocities and diffusion coefficients. Dye drops which form dye patches in the receiving water are made from an aircraft. The changes in position and size of the patches are recorded from two flights over the area. The simplified data processing procedure requires only that the ground coordinates about the dye patches be determined at the time of each flight. With an automatic recording coordinatograph for measuring coordinates and a computer for processing the data, this technique provides a practical method of determining circulation patterns and mixing characteristics of large aquatic systems. This information is useful in assessing the environmental impact of waste water discharges and for industrial plant siting.

  14. Multiple diseases impact survival of pine species planted in red spine stands harvested in spatially variable retention patterns

    Treesearch

    M.E. Ostry; M.J. Moore; C.C. Kern; R.C. Venette; B.J. Palik

    2012-01-01

    Increasing the diversity of species and structure of red pine (Pinus resinosa) is often a management goal in stands simplified by practices such as fire suppression and plantation management in many areas of the Great Lakes Region. One approach to diversification is to convert predominantly even-aged, pure red pine stands to multi-cohort, mixed-...

  15. Weighing up the weighted case mix tool (WCMT): a psychometric investigation using confirmatory factor analysis.

    PubMed

    Duane, B G; Humphris, G; Richards, D; Okeefe, E J; Gordon, K; Freeman, R

    2014-12-01

    To assess the use of the WCMT in two Scottish health boards and to consider the impact of simplifying the tool to improve efficient use. A retrospective analysis of routine WCMT data (47,276 cases). Public Dental Service (PDS) within NHS Lothian and Highland. The WCMT consists of six criteria. Each criterion is measured independently on a four-point scale to assess patient complexity and the dental care for the disabled/impaired patient. Psychometric analyses on the data-set were conducted. Conventional internal consistency coefficients were calculated. Latent variable modelling was performed to assess the 'fit' of the raw data to a pre-specified measurement model. A Confirmatory Factor Analysis (CFA) was used to test three potential changes to the existing WCMT that included, the removal of the oral risk factor question, the removal of original weightings for scoring the Tool, and collapsing the 4-point rating scale to three categories. The removal of the oral risk factor question had little impact on the reliability of the proposed simplified CMT to discriminate between levels of patient complexity. The removal of weighting and collapsing each item's rating scale to three categories had limited impact on reliability of the revised tool. The CFA analysis provided strong evidence that a new, proposed simplified Case Mix Tool (sCMT) would operate closely to the pre-specified measurement model (the WMCT). A modified sCMT can demonstrate, without reducing reliability, a useful measure of the complexity of patient care. The proposed sCMT may be implemented within primary care dentistry to record patient complexity as part of an oral health assessment.

  16. Proceedings of Interservice/Industry Training Systems and Education Conference (16th) Held on 28 November -1 December 1994.

    DTIC Science & Technology

    1994-12-01

    be INTRODUCTION familiar: best value source selection, processes and metrics In simplified terms, acquisition and continuous improvement ; of a training ...pro- continuous improvement , MIL-STD- posed processes and metrics are 1379D, the systems approach to placed in the contract in a training , concurrent...identification and 5 Continuous Process Improvement correction of errors are critical to software product 6 Training correctness and quality. Correcting

  17. Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts.

    PubMed

    Chang, Shun-Chiao; Glymour, M Maria; Rewak, Marissa; Cornelis, Marilyn C; Walter, Stefan; Koenen, Karestan C; Kawachi, Ichiro; Liang, Liming; Tchetgen Tchetgen, Eric J; Kubzansky, Laura D

    2014-01-01

    Some evidence suggests that genetic polymorphisms in oxytocin pathway genes influence various social behaviors, but findings thus far have been mixed. Many studies have been based in small samples and there is possibility of publication bias. Using data from 2 large U.S. prospective cohorts with over 11,000 individuals, we investigated 88 SNPs in OXTR, AVPR1A, and CD38, in relation to social integration (measured as social connectedness in both binary and continuous forms and being continuously married). After correction for multiple testing only one SNP in CD38 (rs12644506) was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness (adjusted p=0.02), but not a continuous measure of social connectedness or the continuously married outcome. A significant gender-heterogeneous effect was identified in one OXTR SNP on dichotomized social connectedness; specifically, rs4686302 T allele was nominally associated with social connectedness in men, whereas the association direction was opposite in women (adjusted gender heterogeneity p=0.02). Furthermore, the rs53576 A allele was significantly associated with social connectedness only in women, and the effect magnitude was stronger in a dominant genetic model (adjusted p=0.003). In summary, our findings suggested that common genetic variants of OXTR, CD38, and AVPR1A are not associated with social integration as measured in this study using the simplified Berkman-Syme Social Network Index, but these findings and other work hint that effects may be modified by gender or other social experiences. Further work considering genetic pathways in relation to social integration may be more fruitful if these additional factors can be more comprehensively evaluated. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts

    PubMed Central

    Chang, Shun-Chiao; Glymour, M Maria; Rewak, Marissa; Cornelis, Marilyn; Walter, Stefan; Koenen, Karestan C; Kawachi, Ichiro; Liang, Liming; Tchetgen, Eric Tchetgen; Kubzansky, Laura D.

    2013-01-01

    Some evidence suggests that genetic polymorphisms in oxytocin pathway genes influence various social behaviors, but findings thus far have been mixed. Many studies have been based in small samples and there is possibility of publication bias. Using data from 2 large U.S. prospective cohorts with over 11,000 individuals, we investigated 88 SNPs in OXTR, AVPR1A, and CD38, in relation to social integration (measured as social connectedness in both binary and continuous forms and being continuously married). After correction for multiple testing only one SNP in CD38 (rs12644506) was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness (adjusted p=0.02), but not a continuous measure of social connectedness or the continuously married outcome. A significant gender-heterogeneous effect was identified in one OXTR SNP on dichotomized social connectedness; specifically, rs4686302 T allele was nominally associated with social connectedness in men, whereas the association direction was opposite in women (adjusted gender heterogeneity p=0.02). Furthermore, the rs53576 A allele was significantly associated with social connectedness only in women, and the effect magnitude was stronger in a dominant genetic model (adjusted p=0.003). In summary, our findings suggested that common genetic variants of OXTR, CD38, and AVPR1A are not associated with social integration as measured in this study using the simplified Berkman-Syme Social Network Index, but these findings and other work hint that effects may be modified by gender or other social experiences. Further work considering genetic pathways in relation to social integration may be more fruitful if these additional factors can be more comprehensively evaluated. PMID:24209975

  19. Investigating the Metallicity–Mixing-length Relation

    NASA Astrophysics Data System (ADS)

    Viani, Lucas S.; Basu, Sarbani; Joel Ong J., M.; Bonaca, Ana; Chaplin, William J.

    2018-05-01

    Stellar models typically use the mixing-length approximation as a way to implement convection in a simplified manner. While conventionally the value of the mixing-length parameter, α, used is the solar-calibrated value, many studies have shown that other values of α are needed to properly model stars. This uncertainty in the value of the mixing-length parameter is a major source of error in stellar models and isochrones. Using asteroseismic data, we determine the value of the mixing-length parameter required to properly model a set of about 450 stars ranging in log g, {T}eff}, and [{Fe}/{{H}}]. The relationship between the value of α required and the properties of the star is then investigated. For Eddington atmosphere, non-diffusion models, we find that the value of α can be approximated by a linear model, in the form of α /{α }ȯ =5.426{--}0.101 {log}(g)-1.071 {log}({T}eff}) +0.437([{Fe}/{{H}}]). This process is repeated using a variety of model physics, as well as compared with previous studies and results from 3D convective simulations.

  20. Application of FTA technology to extraction of sperm DNA from mixed body fluids containing semen.

    PubMed

    Fujita, Yoshihiko; Kubo, Shin-ichi

    2006-01-01

    FTA technology is a novel method designed to simplify the collection, shipment, archiving and purification of nucleic acids from a wide variety of biological sources. In this study, we report a rapid and simple method of extracting DNA from sperm when body fluids mixed with semen were collected using FTA cards. After proteinase K digestion of the sperm and body fluid mixture, the washed pellet suspension as the sperm fraction and the concentrated supernatant as the epithelial cell fraction were respectively applied to FTA cards containing DTT. The FTA cards were dried, then directly added to a polymerase chain reaction (PCR) mix and processed by PCR. The time required from separation of the mixed fluid into sperm and epithelial origin DNA extractions was only about 2.5-3h. Furthermore, the procedure was extremely simple. It is considered that our designed DNA extraction procedure using an FTA card is available for application to routine work.

  1. Update on Area Production in Mixing of Supercritical Fluids

    NASA Technical Reports Server (NTRS)

    Okongo, Nora; Bellan, Josette

    2003-01-01

    The focus of this research is on supercritical C7H16/N2 and O2/H2 mixing layers undergoing transitions to turbulence. The C7H16/N2 system serves as a simplified model of hydrocarbon/air systems in gas-turbine and diesel engines; the O2/H2 system is representative of liquid rocket engines. One goal of this research is to identify ways of controlling area production to increase disintegration of fluids and enhance combustion in such engines. As used in this research, "area production" signifies the fractional rate of change of surface area oriented perpendicular to the mass-fraction gradient of a mixing layer. In the study, a database of transitional states obtained from direct numerical simulations of the aforementioned mixing layers was analyzed to investigate global layer characteristics, phenomena in regions of high density-gradient magnitude (HDGM), irreversible entropy production and its relationship to the HDGM regions, and mechanisms leading to area production.

  2. The computation of standard solar models

    NASA Technical Reports Server (NTRS)

    Ulrich, Roger K.; Cox, Arthur N.

    1991-01-01

    Procedures for calculating standard solar models with the usual simplifying approximations of spherical symmetry, no mixing except in the surface convection zone, no mass loss or gain during the solar lifetime, and no separation of elements by diffusion are described. The standard network of nuclear reactions among the light elements is discussed including rates, energy production and abundance changes. Several of the equation of state and opacity formulations required for the basic equations of mass, momentum and energy conservation are presented. The usual mixing-length convection theory is used for these results. Numerical procedures for calculating the solar evolution, and current evolution and oscillation frequency results for the present sun by some recent authors are given.

  3. The effects of different mixing intensities during anaerobic digestion of the organic fraction of municipal solid waste.

    PubMed

    Lindmark, Johan; Eriksson, Per; Thorin, Eva

    2014-08-01

    Mixing inside an anaerobic digester is often continuous and is not actively controlled. The selected mixing regime can however affect both gas production and the energy efficiency of the biogas plant. This study aims to evaluate these effects and compare three different mixing regimes, 150 RPM and 25 RPM continuous mixing and minimally intermittent mixing for both digestion of fresh substrate and post-digestion of the organic fraction of municipal solid waste. The results show that a lower mixing intensity leads to a higher biogas production rate and higher total biogas production in both cases. 25 RPM continuous mixing and minimally intermittent mixing resulted in similar biogas production after process stabilization, while 150 RPM continuous mixing resulted in lower production throughout the experiment. The lower gas production at 150 RPM could not be explained by the inhibition of volatile fatty acids. Cumulative biogas production until day 31 was 295 ± 2.9, 317 ± 1.9 and 304 ± 2.8N ml/g VS added during digestion of fresh feed and 113 ± 1.3, 134 ± 1.1 and 130 ± 2.3N ml/g VS added during post digestion for the 150 RPM, 25 RPM and minimally mixed intensities respectively. As well as increasing gas production, optimal mixing can improve the energy efficiency of the anaerobic digestion process. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marinov, N.M.; Westbrook, C.K.; Cloutman, L.D.

    Work being carried out at LLNL has concentrated on studies of the role of chemical kinetics in a variety of problems related to hydrogen combustion in practical combustion systems, with an emphasis on vehicle propulsion. Use of hydrogen offers significant advantages over fossil fuels, and computer modeling provides advantages when used in concert with experimental studies. Many numerical {open_quotes}experiments{close_quotes} can be carried out quickly and efficiently, reducing the cost and time of system development, and many new and speculative concepts can be screened to identify those with sufficient promise to pursue experimentally. This project uses chemical kinetic and fluid dynamicmore » computational modeling to examine the combustion characteristics of systems burning hydrogen, either as the only fuel or mixed with natural gas. Oxidation kinetics are combined with pollutant formation kinetics, including formation of oxides of nitrogen but also including air toxics in natural gas combustion. We have refined many of the elementary kinetic reaction steps in the detailed reaction mechanism for hydrogen oxidation. To extend the model to pressures characteristic of internal combustion engines, it was necessary to apply theoretical pressure falloff formalisms for several key steps in the reaction mechanism. We have continued development of simplified reaction mechanisms for hydrogen oxidation, we have implemented those mechanisms into multidimensional computational fluid dynamics models, and we have used models of chemistry and fluid dynamics to address selected application problems. At the present time, we are using computed high pressure flame, and auto-ignition data to further refine the simplified kinetics models that are then to be used in multidimensional fluid mechanics models. Detailed kinetics studies have investigated hydrogen flames and ignition of hydrogen behind shock waves, intended to refine the detailed reactions mechanisms.« less

  5. Using a tracer technique to identify the extent of non-ideal flows in the continuous mixing of non-Newtonian fluids

    NASA Astrophysics Data System (ADS)

    Patel, D.; Ein-Mozaffari, F.; Mehrvar, M.

    2013-05-01

    The identification of non-ideal flows in a continuous-flow mixing of non-Newtonian fluids is a challenging task for various chemical industries: plastic manufacturing, water and wastewater treatment, and pulp and paper manufacturing. Non-ideal flows such as channelling, recirculation, and dead zones significantly affect the performance of continuous-flow mixing systems. Therefore, the main objective of this paper was to develop an identification protocol to measure non-ideal flows in the continuous-flow mixing system. The extent of non-ideal flows was quantified using a dynamic model that incorporated channelling, recirculation, and dead volume in the mixing vessel. To estimate the dynamic model parameters, the system was excited using a frequency-modulated random binary input by injecting the saline solution (as a tracer) into the fresh feed stream prior to being pumped into the mixing vessel. The injection of the tracer was controlled by a computer-controlled on-off solenoid valve. Using the trace technique, the extent of channelling and the effective mixed volume were successfully determined and used as mixing quality criteria. Such identification procedures can be applied at various areas of chemical engineering in order to improve the mixing quality.

  6. Parametric Study of a Mixer/Ejector Nozzle with Mixing Enhancement Devices

    NASA Technical Reports Server (NTRS)

    DalBello, T.; Steffen, C. J., Jr.

    2001-01-01

    A numerical study employing a simplified model of the High Speed Civil Transport mixer/ejector nozzle has been conducted to investigate the effect of tabs (vortex generators) on the mixing process. More complete mixing of the primary and secondary flows within the confined ejector lowers peak exit velocity resulting in reduced jet noise. Tabs were modeled as vortex pairs and inserted into the computational model. The location, size, and number of tabs were varied and its effect on the mixing process is presented here both quantitatively and qualitatively. A baseline case (no tabs) along with six other cases involving two different vortex strengths at three different orientations have been computed and analyzed. The case with the highest vorticity (six vortices representing large tabs) gives the best mixing. It is shown that the influence of the vorticity acts primarily in the forward or middle portions of the duct, significantly alters the flow structure, and promotes some mixing in the lateral direction. Unmixed pockets were found at the top and bottom of the lobe, and more clever placement of tabs improved mixing in the vertical direction. The technique of replacing tabs with vortices shows promise as an efficient tool for quickly optimizing tab placement in lobed mixers.

  7. Mode Reduction and Upscaling of Reactive Transport Under Incomplete Mixing

    NASA Astrophysics Data System (ADS)

    Lester, D. R.; Bandopadhyay, A.; Dentz, M.; Le Borgne, T.

    2016-12-01

    Upscaling of chemical reactions in partially-mixed fluid environments is a challenging problem due to the detailed interactions between inherently nonlinear reaction kinetics and complex spatio-temporal concentration distributions under incomplete mixing. We address this challenge via the development of an order reduction method for the advection-diffusion-reaction equation (ADRE) via projection of the reaction kinetics onto a small number N of leading eigenmodes of the advection-diffusion operator (the so-called "strange eigenmodes" of the flow) as an N-by-N nonlinear system, whilst mixing dynamics only are projected onto the remaining modes. For simple kinetics and moderate Péclet and Damkhöler numbers, this approach yields analytic solutions for the concentration mean, evolving spatio-temporal distribution and PDF in terms of the well-mixed reaction kinetics and mixing dynamics. For more complex kinetics or large Péclet or Damkhöler numbers only a small number of modes are required to accurately quantify the mixing and reaction dynamics in terms of the concentration field and PDF, facilitating greatly simplified approximation and analysis of reactive transport. Approximate solutions of this low-order nonlinear system provide quantiative predictions of the evolving concentration PDF. We demonstrate application of this method to a simple random flow and various mass-action reaction kinetics.

  8. Continuous Precipitation of Ceria Nanoparticles from a Continuous Flow Micromixer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tseng, Chih Heng; Paul, Brian; Chang, Chih-hung

    2013-01-01

    Cerium oxide nanoparticles were continuously precipitated from a solution of cerium(III) nitrate and ammonium hydroxide using a micro-scale T-mixer. Findings show that the method of mixing is important in the ceria precipitation process. In batch mixing and deposition, disintegration and agglomeration dominates the deposited film. In T-mixing and deposition, more uniform nanorod particles are attainable. In addition, it was found that the micromixing approach reduced the exposure of the Ce(OH)3 precipates to oxygen, yielding hydroxide precipates in place of CeO2 precipitates. Advantages of the micro-scale T-mixing approach include shorter mixing times, better control of nanoparticle shape and less agglomeration.

  9. 24 CFR 5.518 - Types of preservation assistance available to mixed families and other families.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... available to mixed families and other families. 5.518 Section 5.518 Housing and Urban Development Office of... Restrictions on Assistance to Noncitizens § 5.518 Types of preservation assistance available to mixed families and other families. (a) Continued assistance—(1) General. A mixed family may receive continued housing...

  10. 24 CFR 5.518 - Types of preservation assistance available to mixed families and other families.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... available to mixed families and other families. 5.518 Section 5.518 Housing and Urban Development Office of... Restrictions on Assistance to Noncitizens § 5.518 Types of preservation assistance available to mixed families and other families. (a) Continued assistance—(1) General. A mixed family may receive continued housing...

  11. 24 CFR 5.518 - Types of preservation assistance available to mixed families and other families.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... available to mixed families and other families. 5.518 Section 5.518 Housing and Urban Development Office of... Restrictions on Assistance to Noncitizens § 5.518 Types of preservation assistance available to mixed families and other families. (a) Continued assistance—(1) General. A mixed family may receive continued housing...

  12. 24 CFR 5.518 - Types of preservation assistance available to mixed families and other families.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... available to mixed families and other families. 5.518 Section 5.518 Housing and Urban Development Office of... Restrictions on Assistance to Noncitizens § 5.518 Types of preservation assistance available to mixed families and other families. (a) Continued assistance—(1) General. A mixed family may receive continued housing...

  13. An Optimal Order Nonnested Mixed Multigrid Method for Generalized Stokes Problems

    NASA Technical Reports Server (NTRS)

    Deng, Qingping

    1996-01-01

    A multigrid algorithm is developed and analyzed for generalized Stokes problems discretized by various nonnested mixed finite elements within a unified framework. It is abstractly proved by an element-independent analysis that the multigrid algorithm converges with an optimal order if there exists a 'good' prolongation operator. A technique to construct a 'good' prolongation operator for nonnested multilevel finite element spaces is proposed. Its basic idea is to introduce a sequence of auxiliary nested multilevel finite element spaces and define a prolongation operator as a composite operator of two single grid level operators. This makes not only the construction of a prolongation operator much easier (the final explicit forms of such prolongation operators are fairly simple), but the verification of the approximate properties for prolongation operators is also simplified. Finally, as an application, the framework and technique is applied to seven typical nonnested mixed finite elements.

  14. A Priori Analysis of Subgrid-Scale Models for Large Eddy Simulations of Supercritical Binary-Species Mixing Layers

    NASA Technical Reports Server (NTRS)

    Okong'o, Nora; Bellan, Josette

    2005-01-01

    Models for large eddy simulation (LES) are assessed on a database obtained from direct numerical simulations (DNS) of supercritical binary-species temporal mixing layers. The analysis is performed at the DNS transitional states for heptane/nitrogen, oxygen/hydrogen and oxygen/helium mixing layers. The incorporation of simplifying assumptions that are validated on the DNS database leads to a set of LES equations that requires only models for the subgrid scale (SGS) fluxes, which arise from filtering the convective terms in the DNS equations. Constant-coefficient versions of three different models for the SGS fluxes are assessed and calibrated. The Smagorinsky SGS-flux model shows poor correlations with the SGS fluxes, while the Gradient and Similarity models have high correlations, as well as good quantitative agreement with the SGS fluxes when the calibrated coefficients are used.

  15. Nitrogen removal from digested slurries using a simplified ammonia stripping technique.

    PubMed

    Provolo, Giorgio; Perazzolo, Francesca; Mattachini, Gabriele; Finzi, Alberto; Naldi, Ezio; Riva, Elisabetta

    2017-11-01

    This study assessed a novel technique for removing nitrogen from digested organic waste based on a slow release of ammonia that was promoted by continuous mixing of the digestate and delivering a continuous air stream across the surface of the liquid. Three 10-day experiments were conducted using two 50-L reactors. In the first two, nitrogen removal efficiencies were evaluated from identical digestates maintained at different temperatures (30°C and 40°C). At the start of the first experiment, the digestates were adjusted to pH 9 using sodium hydroxide, while in the second experiment pH was not adjusted. The highest ammonia removal efficiency (87%) was obtained at 40°C with pH adjustment. However at 40°C without pH adjustment, removal efficiencies of 69% for ammonia and 47% for total nitrogen were obtained. In the third experiment two different digestates were tested at 50°C without pH adjustment. Although the initial chemical characteristics of the digestates were different in this experiment, the ammonia removal efficiencies were very similar (approximately 85%). Despite ammonia removal, the pH increased in all experiments, most likely due to carbon dioxide stripping that was promoted by temperature and mixing. The technique proved to be suitable for removing nitrogen following anaerobic digestion of livestock manure because effective removal was obtained at natural pH (≈8) and 40°C, common operating conditions at typical biogas plants that process manure. Furthermore, the electrical energy requirement to operate the process is limited (estimated to be 3.8kWhm -3 digestate). Further improvements may increase the efficiency and reduce the processing time of this treatment technique. Even without these advances slow-rate air stripping of ammonia is a viable option for reducing the environmental impact associated with animal manure management. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Simplifying Effective Treatment of Chronic Hives in Children

    MedlinePlus

    ... the AAAAI Foundation Donate Utility navigation Español Journals Pollen Counts Annual Meeting Member Login / My Membership Search ... navigation Donate Annual meeting Browse your conditions Check pollen counts Continuing education center Find an allergist / immunologist ...

  17. Facility design consideration for continuous mix production of class 1.3 propellant

    NASA Technical Reports Server (NTRS)

    Williamson, K. L.; Schirk, P. G.

    1994-01-01

    In November of 1989, NASA awarded the Advanced Solid Rocket Motor (ASRM) contract to Lockheed Missiles and Space Company (LMSC) for production of advanced solid rocket motors using the continuous mix process. Aerojet ASRM division (AAD) was selected as the facility operator and RUST International Corporation provided the engineering, procurement, and construction management services. The continuous mix process mandates that the mix and cast facilities be 'close-coupled' along with the premix facilities, creating unique and challenging requirements for the facility designer. The classical approach to handling energetic materials-division into manageable quantities, segregation, and isolation-was not available due to these process requirements and quantities involved. This paper provides a description of the physical facilities, the continuous mix process, and discusses the monitoring and detection techniques used to mitigate hazards and prevent an incident.

  18. Design of simplified maximum-likelihood receivers for multiuser CPM systems.

    PubMed

    Bing, Li; Bai, Baoming

    2014-01-01

    A class of simplified maximum-likelihood receivers designed for continuous phase modulation based multiuser systems is proposed. The presented receiver is built upon a front end employing mismatched filters and a maximum-likelihood detector defined in a low-dimensional signal space. The performance of the proposed receivers is analyzed and compared to some existing receivers. Some schemes are designed to implement the proposed receivers and to reveal the roles of different system parameters. Analysis and numerical results show that the proposed receivers can approach the optimum multiuser receivers with significantly (even exponentially in some cases) reduced complexity and marginal performance degradation.

  19. Lift Recovery for AFC-Enabled High Lift System

    NASA Technical Reports Server (NTRS)

    Shmilovich, Arvin; Yadlin, Yoram; Dickey, Eric D.; Gissen, Abraham N.; Whalen, Edward A.

    2017-01-01

    This project is a continuation of the NASA AFC-Enabled Simplified High-Lift System Integration Study contract (NNL10AA05B) performed by Boeing under the Fixed Wing Project. This task is motivated by the simplified high-lift system, which is advantageous due to the simpler mechanical system, reduced actuation power and lower maintenance costs. Additionally, the removal of the flap track fairings associated with conventional high-lift systems renders a more efficient aerodynamic configuration. Potentially, these benefits translate to a approx. 2.25% net reduction in fuel burn for a twin-engine, long-range airplane.

  20. Mode 2 fatigue crack growth specimen development

    NASA Technical Reports Server (NTRS)

    Buzzard, R. J.; Gross, B.; Srawley, J. E.

    1983-01-01

    A Mode II test specimen was developed which has potential application in understanding phemonena associated with mixed mode fatigue failures in high performance aircraft engine bearing races. The attributes of the specimen are: it contains one single ended notch, which simplifiers data gathering and reduction; the fatigue crack grous in-line with the direction of load application; a single axis test machine is sufficient to perform testing; and the Mode I component is vanishingly small.

  1. On the cross-sensitivity between water vapor mixing ratio and stable isotope measurements of in-situ analyzers

    NASA Astrophysics Data System (ADS)

    Parkes, Stephen; Wang, Lixin; McCabe, Matthew

    2015-04-01

    In recent years there has been an increasing amount of water vapor stable isotope data collected using in-situ instrumentation. A number of papers have characterized the performance of these in-situ analyzers and suggested methods for calibrating raw measurements. The cross-sensitivity of the isotopic measurements on the mixing ratio has been shown to be a major uncertainty and a variety of techniques have been suggested to characterize this inaccuracy. However, most of these are based on relating isotopic ratios to water vapor mixing ratios from in-situ analyzers when the mixing ratio is varied and the isotopic composition kept constant. An additional correction for the span of the isotopic ratio scale is then applied by measuring different isotopic standards. Here we argue that the water vapor cross-sensitivity arises from different instrument responses (span and offset) of the parent H2O isotope and the heavier isotopes, rather than spectral overlap that could cause a true variation in the isotopic ratio with mixing ratio. This is especially relevant for commercial laser optical instruments where absorption lines are well resolved. Thus, the cross-sensitivity determined using more conventional techniques is dependent on the isotopic ratio of the standard used for the characterization, although errors are expected to be small. Consequently, the cross-sensitivity should be determined by characterizing the span and zero offset of each isotope mixing ratio. In fact, this technique makes the span correction for the isotopic ratio redundant. In this work we model the impact of changes in the span and offset of the heavy and light isotopes and illustrate the impact on the cross-sensitivity of the isotopic ratios on water vapor. This clearly shows the importance of determining the zero offset for the two isotopes. The cross-sensitivity of the isotopic ratios on water vapor is then characterized by determining the instrument response for the individual isotopes for a number of different in-situ analyzers that employ different optical methods. We compare this simplified calibration technique to more conventional characterization of both the cross-sensitivity determined in isotopic ratio space and the isotopic ratio span. Utilizing this simplified calibration approach with improved software control can lead to a significant reduction in time spent calibrating in-situ instrumentation or enable an increase in calibration frequency as required to minimize measurement uncertainty.

  2. A simplified real time method to forecast semi-enclosed basins storm surge

    NASA Astrophysics Data System (ADS)

    Pasquali, D.; Di Risio, M.; De Girolamo, P.

    2015-11-01

    Semi-enclosed basins are often prone to storm surge events. Indeed, their meteorological exposition, the presence of large continental shelf and their shape can lead to strong sea level set-up. A real time system aimed at forecasting storm surge may be of great help to protect human activities (i.e. to forecast flooding due to storm surge events), to manage ports and to safeguard coasts safety. This paper aims at illustrating a simple method able to forecast storm surge events in semi-enclosed basins in real time. The method is based on a mixed approach in which the results obtained by means of a simplified physics based model with low computational costs are corrected by means of statistical techniques. The proposed method is applied to a point of interest located in the Northern part of the Adriatic Sea. The comparison of forecasted levels against observed values shows the satisfactory reliability of the forecasts.

  3. A simplified technique of orthograde MTA obturation on the elected canals of posterior teeth: Two case reports.

    PubMed

    Wahengbam, Brucelee; Wahengbam, Pragya; Tikku, Aseem Prakash

    2014-01-01

    This article suggests a simplified technique of orthograde MTA obturation in less accessible canal(s) of posteriors teeth without using costly ultrasonics or specialised carrier. Essentially few finger pluggers, absorbent points and a simple canal projection method were used. The orifice(s) of the elected canal(s) to be obturated with MTA were projected onto the external occlusal surface for easy delivery and predictive instrumentation. The idea was based on 'easy access', 'working one canal with one mix at one time', 'thorough condensation' and 'removal of excess moisture'. In case I, palatal canal of tooth no. 2 with gross apical perforation and suspected VRF was obturated with MTA. And in Case II, tooth no. 19 presented with incomplete furcal fracture extending into the canal was obturated with MTA in all 3 canals unitarily. Dense homogenous MTA obturation was achieved and both cases healed uneventfully.

  4. A simplified scheme for computing radiation transfer in the troposphere

    NASA Technical Reports Server (NTRS)

    Katayama, A.

    1973-01-01

    A scheme is presented, for the heating of clear and cloudy air by solar and infrared radiation transfer, designed for use in tropospheric general circulation models with coarse vertical resolution. A bulk transmission function is defined for the infrared transfer. The interpolation factors, required for computing the bulk transmission function, are parameterized as functions of such physical parameters as the thickness of the layer, the pressure, and the mixing ratio at a reference level. The computation procedure for solar radiation is significantly simplified by the introduction of two basic concepts. The first is that the solar radiation spectrum can be divided into a scattered part, for which Rayleigh scattering is significant but absorption by water vapor is negligible, and an absorbed part for which absorption by water vapor is significant but Rayleigh scattering is negligible. The second concept is that of an equivalent cloud water vapor amount which absorbs the same amount of radiation as the cloud.

  5. 45 CFR 1152.12 - How may a state simplify, consolidate, or substitute federally required state plans?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS INTERGOVERNMENTAL REVIEW OF NATIONAL ENDOWMENT FOR THE ARTS PROGRAMS AND ACTIVITIES § 1152.12 How...

  6. 45 CFR 1152.12 - How may a state simplify, consolidate, or substitute federally required state plans?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE ARTS INTERGOVERNMENTAL REVIEW OF NATIONAL ENDOWMENT FOR THE ARTS PROGRAMS AND ACTIVITIES § 1152.12 How...

  7. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Hazardous waste mixing. 279.21 Section 279.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing...

  8. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Hazardous waste mixing. 279.21 Section 279.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing...

  9. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Hazardous waste mixing. 279.21 Section 279.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing...

  10. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Hazardous waste mixing. 279.21 Section 279.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing...

  11. 40 CFR 279.21 - Hazardous waste mixing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Hazardous waste mixing. 279.21 Section 279.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF USED OIL Standards for Used Oil Generators § 279.21 Hazardous waste mixing...

  12. Analysis for predicting adiabatic wall temperatures with single hole coolant injection into a low speed crossflow

    NASA Astrophysics Data System (ADS)

    Wang, C. R.; Papell, S. S.; Graham, R. W.

    Assuming the local adiabatic wall temperature equals the local total temperature in a low speed coolant mixing layer, integral conservation equations with and without the boundary layer effects are formulated for the mixing layer downstream of a single coolant injection hole oriented at a 30 degree angle to the crossflow. These equations are solved numerically to determine the center line local adiabatic wall temperature and the effective coolant coverage area. Comparison of the numerical results with an existing film cooling experiment indicates that the present analysis permits a simplified but reasonably accurate prediction of the centerline effectiveness and coolant coverage area downstream of a single hole crossflow streamwise injection at 30 degree inclination angle.

  13. Analysis for predicting adiabatic wall temperatures with single hole coolant injection into a low speed crossflow

    NASA Technical Reports Server (NTRS)

    Wang, C. R.; Papell, S. S.; Graham, R. W.

    1981-01-01

    Assuming the local adiabatic wall temperature equals the local total temperature in a low speed coolant mixing layer, integral conservation equations with and without the boundary layer effects are formulated for the mixing layer downstream of a single coolant injection hole oriented at a 30 degree angle to the crossflow. These equations are solved numerically to determine the center line local adiabatic wall temperature and the effective coolant coverage area. Comparison of the numerical results with an existing film cooling experiment indicates that the present analysis permits a simplified but reasonably accurate prediction of the centerline effectiveness and coolant coverage area downstream of a single hole crossflow streamwise injection at 30 degree inclination angle.

  14. Analysis for predicting adiabatic wall temperatures with single hole coolant injection into a low speed crossflow

    NASA Astrophysics Data System (ADS)

    Wang, C. R.; Papell, S. S.; Graham, R. W.

    1981-03-01

    Assuming the local adiabatic wall temperature equals the local total temperature in a low speed coolant mixing layer, integral conservation equations with and without the boundary layer effects are formulated for the mixing layer downstream of a single coolant injection hole oriented at a 30 degree angle to the crossflow. These equations are solved numerically to determine the center-line local adiabatic wall temperature and the effective coolant coverage area. Comparison of the numerical results with an existing film cooling experiment indicates that the present analysis permits a simplified but reasonably accurate prediction of the centerline effectiveness and coolant coverage area downstream of a single hole crossflow streamwise injection at 30-deg inclination angle.

  15. Analysis for predicting adiabatic wall temperatures with single hole coolant injection into a low speed crossflow

    NASA Technical Reports Server (NTRS)

    Wang, C. R.; Papell, S. S.; Graham, R. W.

    1981-01-01

    Assuming the local adiabatic wall temperature equals the local total temperature in a low speed coolant mixing layer, integral conservation equations with and without the boundary layer effects are formulated for the mixing layer downstream of a single coolant injection hole oriented at a 30 degree angle to the crossflow. These equations are solved numerically to determine the center-line local adiabatic wall temperature and the effective coolant coverage area. Comparison of the numerical results with an existing film cooling experiment indicates that the present analysis permits a simplified but reasonably accurate prediction of the centerline effectiveness and coolant coverage area downstream of a single hole crossflow streamwise injection at 30-deg inclination angle.

  16. Experimental testing and modeling analysis of solute mixing at water distribution pipe junctions.

    PubMed

    Shao, Yu; Jeffrey Yang, Y; Jiang, Lijie; Yu, Tingchao; Shen, Cheng

    2014-06-01

    Flow dynamics at a pipe junction controls particle trajectories, solute mixing and concentrations in downstream pipes. The effect can lead to different outcomes of water quality modeling and, hence, drinking water management in a distribution network. Here we have investigated solute mixing behavior in pipe junctions of five hydraulic types, for which flow distribution factors and analytical equations for network modeling are proposed. First, based on experiments, the degree of mixing at a cross is found to be a function of flow momentum ratio that defines a junction flow distribution pattern and the degree of departure from complete mixing. Corresponding analytical solutions are also validated using computational-fluid-dynamics (CFD) simulations. Second, the analytical mixing model is further extended to double-Tee junctions. Correspondingly the flow distribution factor is modified to account for hydraulic departure from a cross configuration. For a double-Tee(A) junction, CFD simulations show that the solute mixing depends on flow momentum ratio and connection pipe length, whereas the mixing at double-Tee(B) is well represented by two independent single-Tee junctions with a potential water stagnation zone in between. Notably, double-Tee junctions differ significantly from a cross in solute mixing and transport. However, it is noted that these pipe connections are widely, but incorrectly, simplified as cross junctions of assumed complete solute mixing in network skeletonization and water quality modeling. For the studied pipe junction types, analytical solutions are proposed to characterize the incomplete mixing and hence may allow better water quality simulation in a distribution network. Published by Elsevier Ltd.

  17. Self-Calibration Approach for Mixed Signal Circuits in Systems-on-Chip

    NASA Astrophysics Data System (ADS)

    Jung, In-Seok

    MOSFET scaling has served industry very well for a few decades by proving improvements in transistor performance, power, and cost. However, they require high test complexity and cost due to several issues such as limited pin count and integration of analog and digital mixed circuits. Therefore, self-calibration is an excellent and promising method to improve yield and to reduce manufacturing cost by simplifying the test complexity, because it is possible to address the process variation effects by means of self-calibration technique. Since the prior published calibration techniques were developed for a specific targeted application, it is not easy to be utilized for other applications. In order to solve the aforementioned issues, in this dissertation, several novel self-calibration design techniques in mixed-signal mode circuits are proposed for an analog to digital converter (ADC) to reduce mismatch error and improve performance. These are essential components in SOCs and the proposed self-calibration approach also compensates the process variations. The proposed novel self-calibration approach targets the successive approximation (SA) ADC. First of all, the offset error of the comparator in the SA-ADC is reduced using the proposed approach by enabling the capacitor array in the input nodes for better matching. In addition, the auxiliary capacitors for each capacitor of DAC in the SA-ADC are controlled by using synthesized digital controller to minimize the mismatch error of the DAC. Since the proposed technique is applied during foreground operation, the power overhead in SA-ADC case is minimal because the calibration circuit is deactivated during normal operation time. Another benefit of the proposed technique is that the offset voltage of the comparator is continuously adjusted for every step to decide one-bit code, because not only the inherit offset voltage of the comparator but also the mismatch of DAC are compensated simultaneously. Synthesized digital calibration control circuit operates as fore-ground mode, and the controller has been highly optimized for low power and better performance with simplified structure. In addition, in order to increase the sampling clock frequency of proposed self-calibration approach, novel variable clock period method is proposed. To achieve high speed SAR operation, a variable clock time technique is used to reduce not only peak current but also die area. The technique removes conversion time waste and extends the SAR operation speed easily. To verify and demonstrate the proposed techniques, a prototype charge-redistribution SA-ADCs with the proposed self-calibration is implemented in a 130nm standard CMOS process. The prototype circuit's silicon area is 0.0715 mm 2 and consumers 4.62mW with 1.2V power supply.

  18. Development of Mix Design Method in Efforts to Increase Concrete Performance Using Portland Pozzolana Cement (PPC)

    NASA Astrophysics Data System (ADS)

    Krisnamurti; Soehardjono, A.; Zacoeb, A.; Wibowo, A.

    2018-01-01

    Earthquake disaster can cause infrastructure damage. Prevention of human casualties from disasters should do. Prevention efforts can do through improving the mechanical performance of building materials. To achieve high-performance concrete (HPC), usually used Ordinary Portland Cement (OPC). However, the most widely circulating cement types today are Portland Pozzolana Cement (PPC) or Portland Composite Cement (PCC). Therefore, the proportion of materials used in the HPC mix design needs to adjust to achieve the expected performance. This study aims to develop a concrete mix design method using PPC to fulfil the criteria of HPC. The study refers to the code/regulation of concrete mixtures that use OPC based on the results of laboratory testing. This research uses PPC material, gravel from Malang area, Lumajang sand, water, silica fume and superplasticizer of a polycarboxylate copolymer. The analyzed information includes the investigation results of aggregate properties, concrete mixed composition, water-binder ratio variation, specimen dimension, compressive strength and elasticity modulus of the specimen. The test results show that the concrete compressive strength achieves value between 25 MPa to 55 MPa. The mix design method that has developed can simplify the process of concrete mix design using PPC to achieve the certain desired performance of concrete.

  19. Clinical review: Continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest

    PubMed Central

    2013-01-01

    There has been a dramatic change in hospital care of cardiac arrest survivors in recent years, including the use of target temperature management (hypothermia). Clinical signs of recovery or deterioration, which previously could be observed, are now concealed by sedation, analgesia, and muscle paralysis. Seizures are common after cardiac arrest, but few centers can offer high-quality electroencephalography (EEG) monitoring around the clock. This is due primarily to its complexity and lack of resources but also to uncertainty regarding the clinical value of monitoring EEG and of treating post-ischemic electrographic seizures. Thanks to technical advances in recent years, EEG monitoring has become more available. Large amounts of EEG data can be linked within a hospital or between neighboring hospitals for expert opinion. Continuous EEG (cEEG) monitoring provides dynamic information and can be used to assess the evolution of EEG patterns and to detect seizures. cEEG can be made more simple by reducing the number of electrodes and by adding trend analysis to the original EEG curves. In our version of simplified cEEG, we combine a reduced montage, displaying two channels of the original EEG, with amplitude-integrated EEG trend curves (aEEG). This is a convenient method to monitor cerebral function in comatose patients after cardiac arrest but has yet to be validated against the gold standard, a multichannel cEEG. We recently proposed a simplified system for interpreting EEG rhythms after cardiac arrest, defining four major EEG patterns. In this topical review, we will discuss cEEG to monitor brain function after cardiac arrest in general and how a simplified cEEG, with a reduced number of electrodes and trend analysis, may facilitate and improve care. PMID:23876221

  20. 46 CFR 170.160 - Specific applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) A vessel that performs one of the simplified stability proof tests described in subpart C of part... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Intact Stability Criteria § 170.160 Specific applicability. (a) Except...

  1. 46 CFR 170.160 - Specific applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) A vessel that performs one of the simplified stability proof tests described in subpart C of part... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Intact Stability Criteria § 170.160 Specific applicability. (a) Except...

  2. 46 CFR 170.160 - Specific applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) A vessel that performs one of the simplified stability proof tests described in subpart C of part... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Intact Stability Criteria § 170.160 Specific applicability. (a) Except...

  3. 46 CFR 170.160 - Specific applicability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) A vessel that performs one of the simplified stability proof tests described in subpart C of part... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY STABILITY REQUIREMENTS FOR ALL INSPECTED VESSELS Intact Stability Criteria § 170.160 Specific applicability. (a) Except...

  4. Life extending control for rocket engines

    NASA Technical Reports Server (NTRS)

    Lorenzo, C. F.; Saus, J. R.; Ray, A.; Carpino, M.; Wu, M.-K.

    1992-01-01

    The concept of life extending control is defined. A brief discussion of current fatigue life prediction methods is given and the need for an alternative life prediction model based on a continuous functional relationship is established. Two approaches to life extending control are considered: (1) the implicit approach which uses cyclic fatigue life prediction as a basis for control design; and (2) the continuous life prediction approach which requires a continuous damage law. Progress on an initial formulation of a continuous (in time) fatigue model is presented. Finally, nonlinear programming is used to develop initial results for life extension for a simplified rocket engine (model).

  5. Comparison of an Agent-based Model of Disease Propagation with the Generalised SIR Epidemic Model

    DTIC Science & Technology

    2009-08-01

    has become a practical method for conducting Epidemiological Modelling. In the agent- based approach the whole township can be modelled as a system of...SIR system was initially developed based on a very simplified model of social interaction. For instance an assumption of uniform population mixing was...simulating the progress of a disease within a host and of transmission between hosts is based upon Transportation Analysis and Simulation System

  6. Quantum standard clocks in the primordial trispectrum

    NASA Astrophysics Data System (ADS)

    Chen, Xingang; Zhen Chua, Wan; Guo, Yuxun; Wang, Yi; Xianyu, Zhong-Zhi; Xie, Tianyou

    2018-05-01

    We calculate the primordial trispectrum of curvature perturbation in quasi-single field inflation, with general sound speeds for both the inflaton and the massive scalar. Special attention is paid to various soft limits of the trispectrum, where the shape function shows characteristic oscillatory pattern (known as the quantum primordial standard clock signal) as a function of the momentum ratio. Our calculation is greatly simplified by using the "mixed propagator" developed under a diagrammatic representation of the in-in formalism.

  7. Using the simplified case mix tool (sCMT) to identify cost in special care dental services to support commissioning.

    PubMed

    Duane, B G; Freeman, R; Richards, D; Crosbie, S; Patel, P; White, S; Humphris, G

    2017-03-01

    To commission dental services for vulnerable (special care) patient groups effectively, consistently and fairly an evidence base is needed of the costs involved. The simplified Case Mixed Tool (sCMT) can assess treatment mode complexity for these patient groups. To determine if the sCMT can be used to identify costs of service provision. Patients (n=495) attending the Sussex Community NHS Trust Special Care Dental Service for care were assessed using the sCMT. sCMT score and costs (staffing, laboratory fees, etc.) besides patient age, whether a new patient and use of general anaesthetic/intravenous sedation. Statistical analysis (adjusted linear regression modelling) compared sCMT score and costs then sensitivity analyses of the costings to age, being a new patient and sedation use were undertaken. Regression tables were produced to present estimates of service costs. Costs increased with sCMT total scale and single item values in a predictable manner in all analyses except for 'cooperation'. Costs increased with the use of IV sedation; with each rising level of the sCMT, and with complexity in every sCMT category, except cooperation. Costs increased with increase in complexity of treatment mode as measured by sCMT scores. Measures such as the sCMT can provide predictions of the resource allocations required when commissioning special care dental services. Copyright© 2017 Dennis Barber Ltd.

  8. 21 CFR 226.102 - Master-formula and batch-production records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...(s) produced on a batch or continuous operation basis, including mixing steps and mixing times that have been determined to yield an adequately mixed Type A medicated article(s); and in the case of Type... batch size, or of appropriate size in the case of continuous systems to be produced from the master...

  9. 26 CFR 1.1092(b)-6T - Mixed straddles; accrued gain and loss associated with a position that becomes part of a section...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 11 2014-04-01 2014-04-01 false Mixed straddles; accrued gain and loss associated with a position that becomes part of a section 1092(b)(2) identified mixed straddle. 1.1092(b)-6T...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Wash Sales of Stock Or Securities § 1.1092(b)-6T Mixed...

  10. Optical analysis for simplified astigmatic correction of non-imaging focusing heliostat

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chong, K.K.

    2010-08-15

    In the previous work, non-imaging focusing heliostat that consists of m x n facet mirrors can carry out continuous astigmatic correction during sun-tracking with the use of only (m + n - 2) controllers. For this paper, a simplified astigmatic correction of non-imaging focusing heliostat is proposed for reducing the number of controllers from (m + n - 2) to only two. Furthermore, a detailed optical analysis of the new proposal has been carried out and the simulated result has shown that the two-controller system can perform comparably well in astigmatic correction with a much simpler and more cost effectivemore » design. (author)« less

  11. 29 CFR 2200.208 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...

  12. 29 CFR 2200.208 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...

  13. 29 CFR 2200.208 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...

  14. 29 CFR 2200.208 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...

  15. 29 CFR 2200.208 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...

  16. Culturing Chick Embryos--A Simplification of New's Method.

    ERIC Educational Resources Information Center

    Downie, J. R.

    1979-01-01

    Describes a simplified version of New's method for culturing early chick embryos. The technique allows continuous observation of the critical first three days of development and the conditions for setting up successful cultures are also presented to help both teachers and students. (HM)

  17. Semi-abelian Z-theory: NLSM+ ϕ 3 from the open string

    NASA Astrophysics Data System (ADS)

    Carrasco, John Joseph M.; Mafra, Carlos R.; Schlotterer, Oliver

    2017-08-01

    We continue our investigation of Z-theory, the second double-copy component of open-string tree-level interactions besides super-Yang-Mills (sYM). We show that the amplitudes of the extended non-linear sigma model (NLSM) recently considered by Cachazo, Cha, and Mizera are reproduced by the leading α '-order of Z-theory amplitudes in the semi-abelian case. The extension refers to a coupling of NLSM pions to bi-adjoint scalars, and the semi-abelian case involves to a partial symmetrization over one of the color orderings that characterize the Z-theory amplitudes. Alternatively, the partial symmetrization corresponds to a mixed interaction among abelian and non-abelian states in the underlying open-superstring amplitude. We simplify these permutation sums via monodromy relations which greatly increase the efficiency in extracting the α '-expansion of these amplitudes. Their α '-corrections encode higher-derivative interactions between NLSM pions and bi-colored scalars all of which obey the duality between color and kinematics. Through double-copy, these results can be used to generate the predictions of supersymmetric Dirac-Born-Infeld-Volkov-Akulov theory coupled with sYM as well as a complete tower of higher-order α '-corrections.

  18. Navier-Stokes computations with finite-rate chemistry for LO2/LH2 rocket engine plume flow studies

    NASA Technical Reports Server (NTRS)

    Dougherty, N. Sam; Liu, Baw-Lin

    1991-01-01

    Computational fluid dynamics methods have been developed and applied to Space Shuttle Main Engine LO2/LH2 plume flow simulation/analysis of airloading and convective base heating effects on the vehicle at high flight velocities and altitudes. New methods are described which were applied to the simulation of a Return-to-Launch-Site abort where the vehicle would fly briefly at negative angles of attack into its own plume. A simplified two-perfect-gases-mixing approach is used where one gas is the plume and the other is air at 180-deg and 135-deg flight angle of attack. Related research has resulted in real gas multiple-plume interaction methods with finite-rate chemistry described herein which are applied to the same high-altitude-flight conditions of 0 deg angle of attack. Continuing research plans are to study Orbiter wake/plume flows at several Mach numbers and altitudes during ascent and then to merge this model with the Shuttle 'nose-to-tail' aerodynamic and SRB plume models for an overall 'nose-to-plume' capability. These new methods are also applicable to future launch vehicles using clustered-engine LO2/LH2 propulsion.

  19. Efficient computation of optimal actions.

    PubMed

    Todorov, Emanuel

    2009-07-14

    Optimal choice of actions is a fundamental problem relevant to fields as diverse as neuroscience, psychology, economics, computer science, and control engineering. Despite this broad relevance the abstract setting is similar: we have an agent choosing actions over time, an uncertain dynamical system whose state is affected by those actions, and a performance criterion that the agent seeks to optimize. Solving problems of this kind remains hard, in part, because of overly generic formulations. Here, we propose a more structured formulation that greatly simplifies the construction of optimal control laws in both discrete and continuous domains. An exhaustive search over actions is avoided and the problem becomes linear. This yields algorithms that outperform Dynamic Programming and Reinforcement Learning, and thereby solve traditional problems more efficiently. Our framework also enables computations that were not possible before: composing optimal control laws by mixing primitives, applying deterministic methods to stochastic systems, quantifying the benefits of error tolerance, and inferring goals from behavioral data via convex optimization. Development of a general class of easily solvable problems tends to accelerate progress--as linear systems theory has done, for example. Our framework may have similar impact in fields where optimal choice of actions is relevant.

  20. Heteroepitaxial Writing of Silicon-on-Sapphire Nanowires.

    PubMed

    Xu, Mingkun; Xue, Zhaoguo; Wang, Jimmy; Zhao, Yaolong; Duan, Yao; Zhu, Guangyao; Yu, Linwei; Xu, Jun; Wang, Junzhuan; Shi, Yi; Chen, Kunji; Roca I Cabarrocas, Pere

    2016-12-14

    The heteroepitaxial growth of crystal silicon thin films on sapphire, usually referred to as SoS, has been a key technology for high-speed mixed-signal integrated circuits and processors. Here, we report a novel nanoscale SoS heteroepitaxial growth that resembles the in-plane writing of self-aligned silicon nanowires (SiNWs) on R-plane sapphire. During a low-temperature growth at <350 °C, compared to that required for conventional SoS fabrication at >900 °C, the bottom heterointerface cultivates crystalline Si pyramid seeds within the catalyst droplet, while the vertical SiNW/catalyst interface subsequently threads the seeds into continuous nanowires, producing self-oriented in-plane SiNWs that follow a set of crystallographic directions of the sapphire substrate. Despite the low-temperature fabrication process, the field effect transistors built on the SoS-SiNWs demonstrate a high on/off ratio of >5 × 10 4 and a peak hole mobility of >50 cm 2 /V·s. These results indicate the novel potential of deploying in-plane SoS nanowire channels in places that require high-performance nanoelectronics and optoelectronics with a drastically reduced thermal budget and a simplified manufacturing procedure.

  1. Unsteady processes in the vicinity of the heliopause: Are we in the LISM yet?

    DOE PAGES

    Pogorelov, N. V.; Borovikov, S. N.; Burlaga, L. F.; ...

    2013-06-13

    As the twin Voyager spacecraft approach the boundary of the heliosphere, they continue returning new and unexplained measurements of the solar wind (SW) protons, energetic particles, and magnetic field that often differ markedly between the two spacecraft. Our recent studies show that time-dependent effects play a crucial role in understanding and interpreting the observational data. Since the SW is unsteady on many different time scales, its interaction with the local interstellar medium (LISM) should reflect the solar rotation and cycle, as well as merged interplanetary disturbances. Even a simplified solar cycle model allowed us to predict in 2009 the possibilitymore » of a negative radial velocity component in the SWas the heliopause is approached. Further analysis shows a nearly vanishing latitudinal velocity component, while the longitudinal component becomes comparable substantial. Here we discuss the change of the magnetic field and plasma properties across the heliopause, which is important for the identification of its spacecraft crossing. In conclusion, we discuss the effects of heliopause instabilities and corotating interaction regions, and demonstrate that Voyagers are unlikely to see a sharp boundary between the SW and the LISM, but rather a mixing layer of varying width.« less

  2. Pursuit-evasion games with information uncertainties for elusive orbital maneuver and space object tracking

    NASA Astrophysics Data System (ADS)

    Shen, Dan; Jia, Bin; Chen, Genshe; Blasch, Erik; Pham, Khanh

    2015-05-01

    This paper develops and evaluates a pursuit-evasion (PE) game approach for elusive orbital maneuver and space object tracking. Unlike the PE games in the literature, where the assumption is that either both players have perfect knowledge of the opponents' positions or use primitive sensing models, the proposed PE approach solves the realistic space situation awareness (SSA) problem with imperfect information, where the evaders will exploit the pursuers' sensing and tracking models to confuse their opponents by maneuvering their orbits to increase the uncertainties, which the pursuers perform orbital maneuvers to minimize. In the game setup, each game player P (pursuer) and E (evader) has its own motion equations with a small continuous low-thrust. The magnitude of the low thrust is fixed and the direction can be controlled by the associated game player. The entropic uncertainty is used to generate the cost functions of game players. The Nash or mixed Nash equilibrium is composed of the directional controls of low-thrusts. Numerical simulations are emulated to demonstrate the performance. Simplified perturbations models (SGP4/SDP4) are exploited to calculate the ground truth of the satellite states (position and speed).

  3. Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

    PubMed Central

    Thayer, Patrick Scott; Orrhult, Linnea Stridh; Martínez, Héctor

    2018-01-01

    Bioprinting is a powerful technique for the rapid and reproducible fabrication of constructs for tissue engineering applications. In this study, both cartilage and skin analogs were fabricated after bioink pre-cellularization utilizing a novel passive mixing unit technique. This technique was developed with the aim to simplify the steps involved in the mixing of a cell suspension into a highly viscous bioink. The resolution of filaments deposited through bioprinting necessitates the assurance of uniformity in cell distribution prior to printing to avoid the deposition of regions without cells or retention of large cell clumps that can clog the needle. We demonstrate the ability to rapidly blend a cell suspension with a bioink prior to bioprinting of both cartilage and skin analogs. Both tissue analogs could be cultured for up to 4 weeks. Histological analysis demonstrated both cell viability and deposition of tissue specific extracellular matrix (ECM) markers such as glycosaminoglycans (GAGs) and collagen I respectively. PMID:29364216

  4. Long-range parametric amplification of THz wave with absorption loss exceeding parametric gain.

    PubMed

    Wang, Tsong-Dong; Huang, Yen-Chieh; Chuang, Ming-Yun; Lin, Yen-Hou; Lee, Ching-Han; Lin, Yen-Yin; Lin, Fan-Yi; Kitaeva, Galiya Kh

    2013-01-28

    Optical parametric mixing is a popular scheme to generate an idler wave at THz frequencies, although the THz wave is often absorbing in the nonlinear optical material. It is widely suggested that the useful material length for co-directional parametric mixing with strong THz-wave absorption is comparable to the THz-wave absorption length in the material. Here we show that, even in the limit of the absorption loss exceeding parametric gain, the THz idler wave can grows monotonically from optical parametric amplification over a much longer distance in a nonlinear optical material until pump depletion. The coherent production of the non-absorbing signal wave can assist the growth of the highly absorbing idler wave. We also show that, for the case of an equal input pump and signal in difference frequency generation, the quick saturation of the THz idler wave predicted from a much simplified and yet popular plane-wave model fails when fast diffraction of the THz wave from the co-propagating optical mixing waves is considered.

  5. Two- and three-dimensional natural and mixed convection simulation using modular zonal models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wurtz, E.; Nataf, J.M.; Winkelmann, F.

    We demonstrate the use of the zonal model approach, which is a simplified method for calculating natural and mixed convection in rooms. Zonal models use a coarse grid and use balance equations, state equations, hydrostatic pressure drop equations and power law equations of the form {ital m} = {ital C}{Delta}{sup {ital n}}. The advantage of the zonal approach and its modular implementation are discussed. The zonal model resolution of nonlinear equation systems is demonstrated for three cases: a 2-D room, a 3-D room and a pair of 3-D rooms separated by a partition with an opening. A sensitivity analysis withmore » respect to physical parameters and grid coarseness is presented. Results are compared to computational fluid dynamics (CFD) calculations and experimental data.« less

  6. Mixed Convective Peristaltic Flow of Water Based Nanofluids with Joule Heating and Convective Boundary Conditions

    PubMed Central

    Hayat, Tasawar; Nawaz, Sadaf; Alsaedi, Ahmed; Rafiq, Maimona

    2016-01-01

    Main objective of present study is to analyze the mixed convective peristaltic transport of water based nanofluids using five different nanoparticles i.e. (Al2O3, CuO, Cu, Ag and TiO2). Two thermal conductivity models namely the Maxwell's and Hamilton-Crosser's are used in this study. Hall and Joule heating effects are also given consideration. Convection boundary conditions are employed. Furthermore, viscous dissipation and heat generation/absorption are used to model the energy equation. Problem is simplified by employing lubrication approach. System of equations are solved numerically. Influence of pertinent parameters on the velocity and temperature are discussed. Also the heat transfer rate at the wall is observed for considered five nanofluids using the two phase models via graphs. PMID:27104596

  7. A simplified method for prediction of long-term prestress loss in post-tensioned concrete bridges.

    DOT National Transportation Integrated Search

    2006-07-01

    Creep and shrinkage of concrete and relaxation of prestressing steel cause time-dependent changes in : the stresses and strains of concrete structures. These changes result in continuous reduction in the : concrete compression stresses and in the ten...

  8. 45 CFR 672.6 - Appearances.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Appearances. 672.6 Section 672.6 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND HEARING... questions of fact or law; (2) consolidation would expedite and simplify consideration of the issues; and (3...

  9. 45 CFR 672.6 - Appearances.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Appearances. 672.6 Section 672.6 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND HEARING... questions of fact or law; (2) consolidation would expedite and simplify consideration of the issues; and (3...

  10. 45 CFR 672.6 - Appearances.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Appearances. 672.6 Section 672.6 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND HEARING... questions of fact or law; (2) consolidation would expedite and simplify consideration of the issues; and (3...

  11. 45 CFR 672.6 - Appearances.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Appearances. 672.6 Section 672.6 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND HEARING... questions of fact or law; (2) consolidation would expedite and simplify consideration of the issues; and (3...

  12. 45 CFR 672.6 - Appearances.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Appearances. 672.6 Section 672.6 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND HEARING... questions of fact or law; (2) consolidation would expedite and simplify consideration of the issues; and (3...

  13. Alcohol impairment of performance on steering and discrete tasks in a driving simulator

    DOT National Transportation Integrated Search

    1974-12-01

    In this program a simplified laboratory simulator was developed to test two types of tasks used in driving on the open road: a continuous "steering task" to regulate against gust induced disturbances and an intermittent "discrete response task" requi...

  14. Further Studies of the Response of Single Rotor Helicopters to Vortex Encounters

    DOT National Transportation Integrated Search

    1985-09-01

    This report is a continuation of the studies described in Reference where a simplified approach to the problem of predicting the uncontrolled response of a single rotor helicopter to an encounter with the wing tip vortex of a large transport aircraft...

  15. Generic Friedberg-Lee symmetry of Dirac neutrinos

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Luo Shu; Xing Zhizhong; Li Xin

    2008-12-01

    We write out the generic Dirac neutrino mass operator which possesses the Friedberg-Lee symmetry and find that its corresponding neutrino mass matrix is asymmetric. Following a simple way to break the Friedberg-Lee symmetry, we calculate the neutrino mass eigenvalues and show that the resultant neutrino mixing pattern is nearly tri-bimaximal. Imposing the Hermitian condition on the neutrino mass matrix, we also show that the simplified ansatz is consistent with current experimental data and favors the normal neutrino mass hierarchy.

  16. [Application of continuous mixing technology in ethanol precipitation process of Salvia miltiorrhiza by using micromixer].

    PubMed

    Gong, Xing-Chu; Shen, Ji-Chen; Qu, Hai-Bin

    2016-12-01

    Continuous pharmaceutical manufacturing is one of the development directions in international pharmaceutical technology. In this study, a continuous mixing technology of ethanol and concentrated extract in the ethanol precipitation of Salvia miltiorrhiza was realized by using a membrane dispersion method. The effects of ethanol flowrate, concentrated extract flowrate, and flowrate ratio on ethanol precipitation results were investigated. With the increase of the flowrates of ethanol and concentrated extract, retention rate of active phenolic acids components was increased, and the total solid removal rate was decreased. The purity of active components in supernatants was mainly affected by the ratio of ethanol flowrate and concentrated extract flowrate. The mixing efficiency of adding ethanol under continuous flow mixing mode in this study was comparable to that of industrial ethanol precipitation. Continuous adding ethanol by using a membrane dispersion mixer is a promising technology with many advantages such as easy enlargement, large production per unit volume, and easy control. Copyright© by the Chinese Pharmaceutical Association.

  17. Application of Synchrotron Techniques in Environmental Science

    EPA Science Inventory

    The complexity of metal contaminated sites has and continues to be simplified to a measure of the total metal content. While total metal content is a critical measure in assessing risk of a contaminated site, total metal content alone does not provide predictive insights on the b...

  18. Health center streamlines use of audiovisual aids.

    PubMed

    Brantz, M H

    1978-09-01

    Audiovisual aids and programs can be used to help provide effective and efficient in-hospital continuing education programs. The cost of audiovisual equipment can be minimized and use can be maximized by implementing standardization policies that identify and simplify the number and types of equipment to be purchased.

  19. 46 CFR 179.212 - Watertight bulkheads for subdivision and damage stability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... this chapter, a monohull vessel which undergoes a simplified stability proof test in accordance with... stability. 179.212 Section 179.212 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) SUBDIVISION, DAMAGE STABILITY, AND WATERTIGHT INTEGRITY Subdivision...

  20. 46 CFR 179.212 - Watertight bulkheads for subdivision and damage stability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... this chapter, a monohull vessel which undergoes a simplified stability proof test in accordance with... stability. 179.212 Section 179.212 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) SUBDIVISION, DAMAGE STABILITY, AND WATERTIGHT INTEGRITY Subdivision...

  1. 46 CFR 179.212 - Watertight bulkheads for subdivision and damage stability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... this chapter, a monohull vessel which undergoes a simplified stability proof test in accordance with... stability. 179.212 Section 179.212 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) SUBDIVISION, DAMAGE STABILITY, AND WATERTIGHT INTEGRITY Subdivision...

  2. 46 CFR 179.212 - Watertight bulkheads for subdivision and damage stability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... this chapter, a monohull vessel which undergoes a simplified stability proof test in accordance with... stability. 179.212 Section 179.212 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) SUBDIVISION, DAMAGE STABILITY, AND WATERTIGHT INTEGRITY Subdivision...

  3. 7 CFR 3015.311 - Simplification, consolidation, or substitution of State plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Simplification, consolidation, or substitution of... (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE UNIFORM FEDERAL ASSISTANCE... Simplification, consolidation, or substitution of State plans. (a) As used in this section: (1) Simplify means...

  4. 29 CFR 2700.107 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Discovery. 2700.107 Section 2700.107 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Simplified Proceedings § 2700.107 Discovery. Discovery is not permitted except as ordered by the Administrative Law Judge. ...

  5. 29 CFR 2700.107 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Discovery. 2700.107 Section 2700.107 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Simplified Proceedings § 2700.107 Discovery. Discovery is not permitted except as ordered by the Administrative Law Judge. ...

  6. 29 CFR 2700.107 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Discovery. 2700.107 Section 2700.107 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Simplified Proceedings § 2700.107 Discovery. Discovery is not permitted except as ordered by the Administrative Law Judge. ...

  7. 29 CFR 2700.107 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Discovery. 2700.107 Section 2700.107 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Simplified Proceedings § 2700.107 Discovery. Discovery is not permitted except as ordered by the Administrative Law Judge. ...

  8. Minimizing mixing intensity to improve the performance of rice straw anaerobic digestion via enhanced development of microbe-substrate aggregates.

    PubMed

    Kim, Moonkyung; Kim, Byung-Chul; Choi, Yongju; Nam, Kyoungphile

    2017-12-01

    The aim of this work was to study the effect of the differential development of microbe-substrate aggregates at different mixing intensities on the performance of anaerobic digestion of rice straw. Batch and semi-continuous reactors were operated for up to 50 and 300days, respectively, under different mixing intensities. In both batch and semi-continuous reactors, minimal mixing conditions exhibited maximum methane production and lignocellulose biodegradability, which both had strong correlations with the development of microbe-substrate aggregates. The results implied that the aggregated microorganisms on the particulate substrate played a key role in rice straw hydrolysis, determining the performance of anaerobic digestion. Increasing the mixing speed from 50 to 150rpm significantly reduced the methane production rate by disintegrating the microbe-substrate aggregates in the semi-continuous reactor. A temporary stress of high-speed mixing fundamentally affected the microbial communities, increasing the possibility of chronic reactor failure. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Continuous/Batch Mg/MgH2/H2O-Based Hydrogen Generator

    NASA Technical Reports Server (NTRS)

    Kindler, Andrew; Huang, Yuhong

    2010-01-01

    A proposed apparatus for generating hydrogen by means of chemical reactions of magnesium and magnesium hydride with steam would exploit the same basic principles as those discussed in the immediately preceding article, but would be designed to implement a hybrid continuous/batch mode of operation. The design concept would simplify the problem of optimizing thermal management and would help to minimize the size and weight necessary for generating a given amount of hydrogen.

  10. The Kineticist’s Workbench: Combining Symbolic and Numerical Methods in the Simulation of Chemical Reaction Mechanisms

    DTIC Science & Technology

    1991-06-01

    algorithms (for the analysis of mechanisms), traditional numerical simulation methods, and algorithms that examine the (continued on back) 14. SUBJECT TERMS ...7540-01-280.S500 )doo’c -O• 98 (; : 89) 2YB 󈧆 Block 13 continued: simulation results and reinterpret them in qualitative terms . Moreover...simulation results and reinterpret them in qualitative terms . Moreover, the Workbench can use symbolic procedures to help guide or simplify the task

  11. The effects of different mixing intensities during anaerobic digestion of the organic fraction of municipal solid waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lindmark, Johan, E-mail: Johan.lindmark@mdh.se; Eriksson, Per; Thorin, Eva, E-mail: Eva.Thorin@mdh.se

    2014-08-15

    Highlights: • Effects of mixing on the anaerobic digestion of municipal solid waste. • Digestion of fresh substrate and post-digestion at three mixing intensities were evaluated. • Mixing performed at 150 RPM, 25 RPM and minimally intermittently. • Increased biogas production rates and yields at lower mixing intensities. - Abstract: Mixing inside an anaerobic digester is often continuous and is not actively controlled. The selected mixing regime can however affect both gas production and the energy efficiency of the biogas plant. This study aims to evaluate these effects and compare three different mixing regimes, 150 RPM and 25 RPM continuousmore » mixing and minimally intermittent mixing for both digestion of fresh substrate and post-digestion of the organic fraction of municipal solid waste. The results show that a lower mixing intensity leads to a higher biogas production rate and higher total biogas production in both cases. 25 RPM continuous mixing and minimally intermittent mixing resulted in similar biogas production after process stabilization, while 150 RPM continuous mixing resulted in lower production throughout the experiment. The lower gas production at 150 RPM could not be explained by the inhibition of volatile fatty acids. Cumulative biogas production until day 31 was 295 ± 2.9, 317 ± 1.9 and 304 ± 2.8 N ml/g VS added during digestion of fresh feed and 113 ± 1.3, 134 ± 1.1 and 130 ± 2.3 N ml/g VS added during post digestion for the 150 RPM, 25 RPM and minimally mixed intensities respectively. As well as increasing gas production, optimal mixing can improve the energy efficiency of the anaerobic digestion process.« less

  12. Lifetime improvement mechanism in organic light-emitting diodes with mixed materials at a heterojunction interface

    NASA Astrophysics Data System (ADS)

    Minagawa, Masahiro; Takahashi, Noriko

    2016-02-01

    To investigate the lifetime improvement mechanism caused by mixing at the heterojunction interface, organic light-emitting diodes (OLEDs) with stacked and mixed 4,4‧-bis[N-(1-naphthyl)-N-phenyl-amino]-biphenyl (α-NPD)/tris(8-hydroxyquinoline)aluminum (Alq3) interfaces were fabricated, and changes in their displacement current due to continuous operation were measured. A decrease in accumulated holes at the α-NPD/Alq3 interface was observed in the stacked configuration devices over longer operations. These results indicate that the injected hole density was reduced during continuous operation, implying that the carrier balance became uneven in the emission region. However, few accumulated holes and changes in the displacement current due to continuous operation were observed in the devices having the mixed layer. Therefore, it was deduced that the number of holes concentrated between the α-NPD and Alq3 layers was decreased by mixing at the heterojunction interface, and that the change in the number of holes was smaller during continuous operation, resulting in less degradation.

  13. Progress in color reflection holography

    NASA Astrophysics Data System (ADS)

    Bjelkhagen, Hans I.; Huang, Qiang; Jeong, Tung H.

    1998-02-01

    The recording technique of Denisyuk color reflection holograms has been simplified by using `white' laser light. The Slavich red-green-blue (RGB) sensitized ultra-high resolution silver halide emulsion was used for the hologram recording. The employed laser wavelengths were 633 nm, 531 nm, and 476 nm, generated by a helium-neon, a mixed argon- krypton ion, and an argon ion laser, respectively. A beam combination mechanism with dichroic filters enabled a simultaneously RGB exposure, which made the color balance and overall exposure energy easy to control as well as simplifying the recording procedure. Various approaches have been investigated in generating color hologram which have sufficiently high diffraction efficiency combined with improved color saturation. A specially designed test object consisting of the 1931 CIE chromaticity diagram, a rainbow ribbon cable, pure yellow dots, and a cloisonne elephant was used for color recording experiments. In addition, the Macbeth Color Checker chart was used. Both colorimetric evaluation and scattering noise measurements were performed using the PR-650 Photo Research SpectraScan SpectraCalorimeter.

  14. Efficient parallel resolution of the simplified transport equations in mixed-dual formulation

    NASA Astrophysics Data System (ADS)

    Barrault, M.; Lathuilière, B.; Ramet, P.; Roman, J.

    2011-03-01

    A reactivity computation consists of computing the highest eigenvalue of a generalized eigenvalue problem, for which an inverse power algorithm is commonly used. Very fine modelizations are difficult to treat for our sequential solver, based on the simplified transport equations, in terms of memory consumption and computational time. A first implementation of a Lagrangian based domain decomposition method brings to a poor parallel efficiency because of an increase in the power iterations [1]. In order to obtain a high parallel efficiency, we improve the parallelization scheme by changing the location of the loop over the subdomains in the overall algorithm and by benefiting from the characteristics of the Raviart-Thomas finite element. The new parallel algorithm still allows us to locally adapt the numerical scheme (mesh, finite element order). However, it can be significantly optimized for the matching grid case. The good behavior of the new parallelization scheme is demonstrated for the matching grid case on several hundreds of nodes for computations based on a pin-by-pin discretization.

  15. Environmental and human monitoring of Americium-241 utilizing extraction chromatography and alpha-spectrometry.

    PubMed

    Goldstein, S J; Hensley, C A; Armenta, C E; Peters, R J

    1997-03-01

    Recent developments in extraction chromatography have simplified the separation of americium from complex matrices in preparation for alpha-spectroscopy relative to traditional methods. Here we present results of procedures developed/adapted for water, air, and bioassay samples with less than 1 g of inorganic residue. Prior analytical methods required the use of a complex, multistage procedure for separation of americium from these matrices. The newer, simplified procedure requires only a single 2 mL extraction chromatographic separation for isolation of Am and lanthanides from other components of the sample. This method has been implemented on an extensive variety of "real" environmental and bioassay samples from the Los Alamos area, and consistently reliable and accurate results with appropriate detection limits have been obtained. The new method increases analytical throughput by a factor of approximately 2 and decreases environmental hazards from acid and mixed-waste generation relative to the prior technique. Analytical accuracy, reproducibility, and reliability are also significantly improved over the more complex and laborious method used previously.

  16. Segregation of asphalt mixes caused by surge silos : final report.

    DOT National Transportation Integrated Search

    1982-01-01

    Segregation of asphalt mixes continues to be a problem in Virginia, particularly with base mixes and coarse surface mixes. Although the problem is encountered primarily on jobs using surge silos, it has been related to other factors such as mix desig...

  17. Strategic enzyme patterning for microfluidic biofuel cells

    NASA Astrophysics Data System (ADS)

    Kjeang, E.; Sinton, D.; Harrington, D. A.

    The specific character of biological enzyme catalysts enables combined fuel and oxidant channels and simplified non-compartmentalized fuel cell assemblies. In this work, a microstructured enzymatic biofuel cell architecture is proposed, and species transport phenomena combined with consecutive chemical reactions are studied computationally in order to provide guidelines for optimization. This is the first computational study of this technology, and a 2D CFD model for species transport coupled with laminar fluid flow and Michaelis-Menten enzyme kinetics is established. It is shown that the system is reaction rate limited, indicating that enzyme specific turnover numbers are key parameters for biofuel cell performance. Separated and mixed enzyme patterns in different proportions are analyzed for various Peclet numbers. High fuel utilization is achieved in the diffusion dominated and mixed species transport regimes with separated enzymes arranged in relation to individual turnover rates. However, the Peclet number has to be above a certain threshold value to obtain satisfying current densities. The mixed transport regime is particularly attractive while current densities are maintained close to maximum levels. Optimum performance is achieved by mixed enzyme patterning tailored with respect to individual turnover rates, enabling high current densities combined with nearly complete fuel utilization.

  18. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens.

    PubMed

    Sidiq, Mohsin; Yousuf, Asif; Bhat, Manohar; Sharma, Rajesh; Bhargava, Neha; Ganta, Shravani

    2015-01-01

    The aim of this case study was to report a potentially convenient approach instead of a conventional orthodontic procedure for correcting severe rotation of anterior tooth of an 11-year-old Indian boy, with a mixed dentition class I malocclusion. The child reported seeking treatment for severely rotated upper right central incisor with mesiodens and a single tooth crossbite. The supernumerary tooth was first extracted and bondable buttons were placed on the rotated tooth, an appliance composed of a removable plate with Adam's clasp with distal extension and a loop for engagement of elastics was delivered. Circumferential supracrestal fibrotomy was performed on the corrected derotated tooth. Then, Hawley's appliance with a z-spring and posterior bite plane was fabricated and placed for correction of crossbite. Thus, this removable appliance can be a simplified and a cost-effective treatment alternative for derotation of anterior tooth, especially during the mixed dentition period. How to cite this article: Sidiq M, Yousuf A, Bhat M, Sharma R, Bhargava N, Ganta S. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens. Int J Clin Pediatr Dent 2015;8(3):234-238.

  19. An Investigation of Fully Modulated, Turbulent Diffusion Flames in Reduced Gravity

    NASA Technical Reports Server (NTRS)

    Hermanson, J. C.; Johari, H.; Usowicz, J. E.; Sangras, R.; Stocker, D. P.; Hegde, U. G.; Nagashima, T.; Obata, S.

    2001-01-01

    Pulsed combustion appears to have the potential to provide for rapid fuel/air mixing, compact and economical combustors, and reduced exhaust emissions. The objective of this Flight-Definition experiment (PuFF, for Pulsed-Fully Flames) is to increase the fundamental understanding of the fuel/air mixing and combustion behavior of pulsed, turbulent diffusion flames by conducting experiments in microgravity. In this research the fuel jet is fully modulated (i.e., completely shut off between pulses) by an externally controlled valve system. This gives rise to drastic modification of the combustion and flow characteristics of flames, leading to enhanced fuel/air mixing mechanisms not operative for the case of acoustically excited or partially-modulated jets. The fully-modulated injection approach also simplifies the combustion process by avoiding the acoustic forcing generally present in pulsed combustors. Relatively little is known about the behavior of turbulent flames in reduced-gravity conditions, even in the absence of pulsing. Fundamental issues addressed in this experiment include the impact of buoyancy on the fuel/air mixing and combustion characteristics of fully-modulated flames. It is also important for the planned space experiments to establish the effects of confinement and oxidizer co-flow on these flames.

  20. The evaporatively driven cloud-top mixing layer

    NASA Astrophysics Data System (ADS)

    Mellado, Juan Pedro

    2010-11-01

    Turbulent mixing caused by the local evaporative cooling at the top cloud-boundary of stratocumuli will be discussed. This research is motivated by the lack of a complete understanding of several phenomena in that important region, which translates into an unacceptable variability of order one in current models, including those employed in climate research. The cloud-top mixing layer is a simplified surrogate to investigate, locally, particular aspects of the fluid dynamics at the boundary between the stratocumulus clouds and the upper cloud-free air. In this work, direct numerical simulations have been used to study latent heat effects. The problem is the following: When the cloud mixes with the upper cloud-free layer, relatively warm and dry, evaporation tends to cool the mixture and, if strong enough, the buoyancy reversal instability develops. This instability leads to a turbulent convection layer growing next to the upper boundary of the cloud, which is, in several aspects, similar to free convection below a cold horizontal surface. In particular, results show an approximately self-preserving behavior that is characterized by the molecular buoyancy flux at the inversion base, fact that helps to explain the difficulties found when doing large-eddy simulations of this problem using classical subgrid closures.

  1. Modelling exhaust plume mixing in the near field of an aircraft

    NASA Astrophysics Data System (ADS)

    Garnier, F.; Brunet, S.; Jacquin, L.

    1997-11-01

    A simplified approach has been applied to analyse the mixing and entrainment processes of the engine exhaust through their interaction with the vortex wake of an aircraft. Our investigation is focused on the near field, extending from the exit nozzle until about 30 s after the wake is generated, in the vortex phase. This study was performed by using an integral model and a numerical simulation for two large civil aircraft: a two-engine Airbus 330 and a four-engine Boeing 747. The influence of the wing-tip vortices on the dilution ratio (defined as a tracer concentration) shown. The mixing process is also affected by the buoyancy effect, but only after the jet regime, when the trapping in the vortex core has occurred. In the early wake, the engine jet location (i.e. inboard or outboard engine jet) has an important influence on the mixing rate. The plume streamlines inside the vortices are subject to distortion and stretching, and the role of the descent of the vortices on the maximum tracer concentration is discussed. Qualitative comparison with contrail photograph shows similar features. Finally, tracer concentration of inboard engine centreline of B-747 are compared with other theoretical analyses and measured data.

  2. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens

    PubMed Central

    Sidiq, Mohsin; Bhat, Manohar; Sharma, Rajesh; Bhargava, Neha; Ganta, Shravani

    2015-01-01

    ABSTRACT The aim of this case study was to report a potentially convenient approach instead of a conventional orthodontic procedure for correcting severe rotation of anterior tooth of an 11-year-old Indian boy, with a mixed dentition class I malocclusion. The child reported seeking treatment for severely rotated upper right central incisor with mesiodens and a single tooth crossbite. The supernumerary tooth was first extracted and bondable buttons were placed on the rotated tooth, an appliance composed of a removable plate with Adam’s clasp with distal extension and a loop for engagement of elastics was delivered. Circumferential supracrestal fibrotomy was performed on the corrected derotated tooth. Then, Hawley’s appliance with a z-spring and posterior bite plane was fabricated and placed for correction of crossbite. Thus, this removable appliance can be a simplified and a cost-effective treatment alternative for derotation of anterior tooth, especially during the mixed dentition period. How to cite this article: Sidiq M, Yousuf A, Bhat M, Sharma R, Bhargava N, Ganta S. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens. Int J Clin Pediatr Dent 2015;8(3):234-238. PMID:26604544

  3. Quantum-like dynamics applied to cognition: a consideration of available options

    NASA Astrophysics Data System (ADS)

    Broekaert, Jan; Basieva, Irina; Blasiak, Pawel; Pothos, Emmanuel M.

    2017-10-01

    Quantum probability theory (QPT) has provided a novel, rich mathematical framework for cognitive modelling, especially for situations which appear paradoxical from classical perspectives. This work concerns the dynamical aspects of QPT, as relevant to cognitive modelling. We aspire to shed light on how the mind's driving potentials (encoded in Hamiltonian and Lindbladian operators) impact the evolution of a mental state. Some existing QPT cognitive models do employ dynamical aspects when considering how a mental state changes with time, but it is often the case that several simplifying assumptions are introduced. What kind of modelling flexibility does QPT dynamics offer without any simplifying assumptions and is it likely that such flexibility will be relevant in cognitive modelling? We consider a series of nested QPT dynamical models, constructed with a view to accommodate results from a simple, hypothetical experimental paradigm on decision-making. We consider Hamiltonians more complex than the ones which have traditionally been employed with a view to explore the putative explanatory value of this additional complexity. We then proceed to compare simple models with extensions regarding both the initial state (e.g. a mixed state with a specific orthogonal decomposition; a general mixed state) and the dynamics (by introducing Hamiltonians which destroy the separability of the initial structure and by considering an open-system extension). We illustrate the relations between these models mathematically and numerically. This article is part of the themed issue `Second quantum revolution: foundational questions'.

  4. The EMC Informationist Chair: 2009 A Year in Review

    DTIC Science & Technology

    2010-01-31

    the right level or at the right volume: Is the information necessary or nice to have? Is it value added? Current political ‘ cloak & dagger ’ (an...their efforts to systematically attack these challenges and continue to work within our own government channels to simplify our processes to reduce

  5. 46 CFR 47.100 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Purpose. 47.100 Section 47.100 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LOAD LINES COMBINATION LOAD LINES General § 47.100 Purpose. (a) The purpose of the regulations in this part is to set forth simplified alternative marking schemes for...

  6. 7 CFR 58.619 - Mix processing room.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Mix processing room. 58.619 Section 58.619 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards....619 Mix processing room. The rooms used for combining mix ingredients and processing the mix shall...

  7. 7 CFR 58.619 - Mix processing room.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Mix processing room. 58.619 Section 58.619 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards....619 Mix processing room. The rooms used for combining mix ingredients and processing the mix shall...

  8. 7 CFR 58.619 - Mix processing room.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Mix processing room. 58.619 Section 58.619 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards....619 Mix processing room. The rooms used for combining mix ingredients and processing the mix shall...

  9. 7 CFR 58.637 - Cooling the mix.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Cooling the mix. 58.637 Section 58.637 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  10. 7 CFR 58.638 - Freezing the mix.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Freezing the mix. 58.638 Section 58.638 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  11. 7 CFR 58.638 - Freezing the mix.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Freezing the mix. 58.638 Section 58.638 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  12. 7 CFR 58.619 - Mix processing room.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Mix processing room. 58.619 Section 58.619 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  13. 7 CFR 58.619 - Mix processing room.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Mix processing room. 58.619 Section 58.619 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  14. 7 CFR 58.634 - Assembling and combining mix ingredients.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Assembling and combining mix ingredients. 58.634 Section 58.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS...

  15. 7 CFR 58.634 - Assembling and combining mix ingredients.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Assembling and combining mix ingredients. 58.634 Section 58.634 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS...

  16. 7 CFR 58.637 - Cooling the mix.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Cooling the mix. 58.637 Section 58.637 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  17. 29 CFR 1926.1086 - Mixed-gas diving.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Diving Specific Operations Procedures § 1926.1086 Mixed-gas diving. Note: The requirements applicable to construction work under this section are...

  18. A weak Hamiltonian finite element method for optimal guidance of an advanced launch vehicle

    NASA Technical Reports Server (NTRS)

    Hodges, Dewey H.; Calise, Anthony J.; Bless, Robert R.; Leung, Martin

    1989-01-01

    A temporal finite-element method based on a mixed form of the Hamiltonian weak principle is presented for optimal control problems. The mixed form of this principle contains both states and costates as primary variables, which are expanded in terms of nodal values and simple shape functions. Time derivatives of the states and costates do not appear in the governing variational equation; the only quantities whose time derivatives appear therein are virtual states and virtual costates. Numerical results are presented for an elementary trajectory optimization problem; they show very good agreement with the exact solution along with excellent computational efficiency and self-starting capability. The feasibility of this approach for real-time guidance applications is evaluated. A simplified model for an advanced launch vehicle application that is suitable for finite-element solution is presented.

  19. Dynamics and Hall-edge-state mixing of localized electrons in a two-channel Mach-Zehnder interferometer

    NASA Astrophysics Data System (ADS)

    Bellentani, Laura; Beggi, Andrea; Bordone, Paolo; Bertoni, Andrea

    2018-05-01

    We present a numerical study of a multichannel electronic Mach-Zehnder interferometer, based on magnetically driven noninteracting edge states. The electron path is defined by a full-scale potential landscape on the two-dimensional electron gas at filling factor 2, assuming initially only the first Landau level as filled. We tailor the two beamsplitters with 50 % interchannel mixing and measure Aharonov-Bohm oscillations in the transmission probability of the second channel. We perform time-dependent simulations by solving the electron Schrödinger equation through a parallel implementation of the split-step Fourier method, and we describe the charge-carrier wave function as a Gaussian wave packet of edge states. We finally develop a simplified theoretical model to explain the features observed in the transmission probability, and we propose possible strategies to optimize gate performances.

  20. Impact of Resolution in Multi-Conjugate Adaptive Optics Systems Using Segmented Mirrors (Preprint)

    DTIC Science & Technology

    2009-06-01

    and 100 percent fill factor. The DM1 influence function for each subaperture is modelled as a rectangle. As the apparent resolution of DM1 in the...modelled as a continuous facesheet. To account for the impact of adjoining actuators, an influence function is applied which essentially smoothes out...continuous DMs.20 Lukin’s influence function is closer to that of Jagourel and Gafford,21 or more simplified than the general higher order Gaussian function

  1. Computational Model Prediction and Biological Validation Using Simplified Mixed Field Exposures for the Development of a GCR Reference Field

    NASA Technical Reports Server (NTRS)

    Hada, M.; Rhone, J.; Beitman, A.; Saganti, P.; Plante, I.; Ponomarev, A.; Slaba, T.; Patel, Z.

    2018-01-01

    The yield of chromosomal aberrations has been shown to increase in the lymphocytes of astronauts after long-duration missions of several months in space. Chromosome exchanges, especially translocations, are positively correlated with many cancers and are therefore a potential biomarker of cancer risk associated with radiation exposure. Although extensive studies have been carried out on the induction of chromosomal aberrations by low- and high-LET radiation in human lymphocytes, fibroblasts, and epithelial cells exposed in vitro, there is a lack of data on chromosome aberrations induced by low dose-rate chronic exposure and mixed field beams such as those expected in space. Chromosome aberration studies at NSRL will provide the biological validation needed to extend the computational models over a broader range of experimental conditions (more complicated mixed fields leading up to the galactic cosmic rays (GCR) simulator), helping to reduce uncertainties in radiation quality effects and dose-rate dependence in cancer risk models. These models can then be used to answer some of the open questions regarding requirements for a full GCR reference field, including particle type and number, energy, dose rate, and delivery order. In this study, we designed a simplified mixed field beam with a combination of proton, helium, oxygen, and iron ions with shielding or proton, helium, oxygen, and titanium without shielding. Human fibroblasts cells were irradiated with these mixed field beam as well as each single beam with acute and chronic dose rate, and chromosome aberrations (CA) were measured with 3-color fluorescent in situ hybridization (FISH) chromosome painting methods. Frequency and type of CA induced with acute dose rate and chronic dose rates with single and mixed field beam will be discussed. A computational chromosome and radiation-induced DNA damage model, BDSTRACKS (Biological Damage by Stochastic Tracks), was updated to simulate various types of CA induced by acute exposures of the mixed field beams used for the experiments. The chromosomes were simulated by a polymer random walk algorithm with restrictions to their respective domains in the nucleus [1]. The stochastic dose to the nucleus was calculated with the code RITRACKS [2]. Irradiation of a target volume by a mixed field of ions was implemented within RITRACKs, and the fields of ions can be delivered over specific periods of time, allowing the simulation of dose-rate effects. Similarly, particles of various types and energies extracted from a pre-calculated spectra of galactic cosmic rays (GCR) can be used in RITRACKS. The number and spatial location of DSBs (DNA double-strand breaks) were calculated in BDSTRACKS using the simulated chromosomes and local (voxel) dose. Assuming that DSBs led to chromosome breaks, and simulating the rejoining of damaged chromosomes occurring during repair, BDSTRACKS produces the yield of various types of chromosome aberrations as a function of time (only final yields are presented). A comparison between experimental and simulation results will be shown.

  2. 7 CFR 58.635 - Pasteurization of the mix.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Pasteurization of the mix. 58.635 Section 58.635 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  3. 7 CFR 58.635 - Pasteurization of the mix.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Pasteurization of the mix. 58.635 Section 58.635 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  4. Kinetic multi-layer model of aerosol surface and bulk chemistry (KM-SUB): the influence of interfacial transport and bulk diffusion on the oxidation of oleic acid by ozone

    NASA Astrophysics Data System (ADS)

    Shiraiwa, Manabu; Pfrang, Christian; Pöschl, Ulrich

    2010-05-01

    Aerosols are ubiquitous in the atmosphere and have strong effects on climate and public health. Gas-particle interactions can significantly change the physical and chemical properties of aerosols such as toxicity, reactivity, hygroscopicity and radiative properties. Chemical reactions and mass transport lead to continuous transformation and changes in the composition of atmospheric aerosols ("chemical aging"). Resistor model formulations are widely used to describe and investigate heterogeneous reactions and multiphase processes in laboratory, field and model studies of atmospheric chemistry. The traditional resistor models, however, are usually based on simplifying assumptions such as steady state conditions, homogeneous mixing, and limited numbers of non-interacting species and processes. In order to overcome these limitations, Pöschl, Rudich and Ammann have developed a kinetic model framework (PRA framework) with a double-layer surface concept and universally applicable rate equations and parameters for mass transport and chemical reactions at the gas-particle interface of aerosols and clouds [1]. Based on the PRA framework, we present a novel kinetic multi-layer model that explicitly resolves mass transport and chemical reaction at the surface and in the bulk of aerosol particles (KM-SUB) [2]. The model includes reversible adsorption, surface reactions and surface-bulk exchange as well as bulk diffusion and reaction. Unlike earlier models, KM-SUB does not require simplifying assumptions about steady-state conditions and radial mixing. The temporal evolution and concentration profiles of volatile and non-volatile species at the gas-particle interface and in the particle bulk can be modeled along with surface concentrations and gas uptake coefficients. In this study we explore and exemplify the effects of bulk diffusion on the rate of reactive gas uptake for a simple reference system, the ozonolysis of oleic acid particles, in comparison to experimental data and earlier model studies. We demonstrate how KM-SUB can be used to interpret and analyze experimental data from laboratory studies, and how the results can be extrapolated to atmospheric conditions. In particular, we show how interfacial transport and bulk transport, i.e., surface accommodation, bulk accommodation and bulk diffusion, influence the kinetics of the chemical reaction. Sensitivity studies suggest that in fine air particulate matter oleic acid and compounds with similar reactivity against ozone (C=C double bonds) can reach chemical life-times of multiple hours only if they are embedded in a (semi-)solid matrix with very low diffusion coefficients (~10-10 cm2 s-1). Depending on the complexity of the investigated system, unlimited numbers of volatile and non-volatile species and chemical reactions can be flexibly added and treated with KM-SUB. We propose and intend to pursue the application of KM-SUB as a basis for the development of a detailed master mechanism of aerosol chemistry as well as for the derivation of simplified but realistic parameterizations for large-scale atmospheric and climate models. References [1] Pöschl et al., Atmos. Chem. and Phys., 7, 5989-6023 (2007). [2] Shiraiwa et al., Atmos. Chem. Phys. Discuss., 10, 281-326 (2010).

  5. A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut+/pAOX1-lacZ strain

    PubMed Central

    2013-01-01

    Background One of the main challenges for heterologous protein production by the methylotrophic yeast Pichia pastoris at large-scale is related to its high oxygen demand. A promising solution is a co-feeding strategy based on a methanol/sorbitol mixture during the induction phase. Nonetheless, a deep understanding of the cellular physiology and the regulation of the AOX1 promoter, used to govern heterologous protein production, during this co-feeding strategy is still scarce. Results Transient continuous cultures with a dilution rate of 0.023 h-1 at 25°C were performed to quantitatively assess the benefits of a methanol/sorbitol co-feeding process with a Mut+ strain in which the pAOX1-lacZ construct served as a reporter gene. Cell growth and metabolism, including O2 consumption together with CO2 and heat production were analyzed with regard to a linear change of methanol fraction in the mixed feeding media. In addition, the regulation of the promoter AOX1 was investigated by means of β-galactosidase measurements. Our results demonstrated that the cell-specific oxygen consumption (qO2) could be reduced by decreasing the methanol fraction in the feeding media. More interestingly, maximal β-galactosidase cell-specific activity (>7500 Miller unit) and thus, optimal pAOX1 induction, was achieved and maintained in the range of 0.45 ~ 0.75 C-mol/C-mol of methanol fraction. In addition, the qO2 was reduced by 30% at most in those conditions. Based on a simplified metabolic network, metabolic flux analysis (MFA) was performed to quantify intracellular metabolic flux distributions during the transient continuous cultures, which further shed light on the advantages of methanol/sorbitol co-feeding process. Finally, our observations were further validated in fed-batch cultures. Conclusion This study brings quantitative insight into the co-feeding process, which provides valuable data for the control of methanol/sorbitol co-feeding, aiming at enhancing biomass and heterologous protein productivities under given oxygen supply. According to our results, β-galactosidase productivity could be improved about 40% using the optimally mixed feed. PMID:23565774

  6. A quantitative study of methanol/sorbitol co-feeding process of a Pichia pastoris Mut⁺/pAOX1-lacZ strain.

    PubMed

    Niu, Hongxing; Jost, Laurent; Pirlot, Nathalie; Sassi, Hosni; Daukandt, Marc; Rodriguez, Christian; Fickers, Patrick

    2013-04-08

    One of the main challenges for heterologous protein production by the methylotrophic yeast Pichia pastoris at large-scale is related to its high oxygen demand. A promising solution is a co-feeding strategy based on a methanol/sorbitol mixture during the induction phase. Nonetheless, a deep understanding of the cellular physiology and the regulation of the AOX1 promoter, used to govern heterologous protein production, during this co-feeding strategy is still scarce. Transient continuous cultures with a dilution rate of 0.023 h(-1) at 25°C were performed to quantitatively assess the benefits of a methanol/sorbitol co-feeding process with a Mut+ strain in which the pAOX1-lacZ construct served as a reporter gene. Cell growth and metabolism, including O2 consumption together with CO2 and heat production were analyzed with regard to a linear change of methanol fraction in the mixed feeding media. In addition, the regulation of the promoter AOX1 was investigated by means of β-galactosidase measurements. Our results demonstrated that the cell-specific oxygen consumption (qO2) could be reduced by decreasing the methanol fraction in the feeding media. More interestingly, maximal β-galactosidase cell-specific activity (>7500 Miller unit) and thus, optimal pAOX1 induction, was achieved and maintained in the range of 0.45 ~ 0.75 C-mol/C-mol of methanol fraction. In addition, the qO2 was reduced by 30% at most in those conditions. Based on a simplified metabolic network, metabolic flux analysis (MFA) was performed to quantify intracellular metabolic flux distributions during the transient continuous cultures, which further shed light on the advantages of methanol/sorbitol co-feeding process. Finally, our observations were further validated in fed-batch cultures. This study brings quantitative insight into the co-feeding process, which provides valuable data for the control of methanol/sorbitol co-feeding, aiming at enhancing biomass and heterologous protein productivities under given oxygen supply. According to our results, β-galactosidase productivity could be improved about 40% using the optimally mixed feed.

  7. Cluster analysis and prediction of treatment outcomes for chronic rhinosinusitis.

    PubMed

    Soler, Zachary M; Hyer, J Madison; Rudmik, Luke; Ramakrishnan, Viswanathan; Smith, Timothy L; Schlosser, Rodney J

    2016-04-01

    Current clinical classifications of chronic rhinosinusitis (CRS) have weak prognostic utility regarding treatment outcomes. Simplified discriminant analysis based on unsupervised clustering has identified novel phenotypic subgroups of CRS, but prognostic utility is unknown. We sought to determine whether discriminant analysis allows prognostication in patients choosing surgery versus continued medical management. A multi-institutional prospective study of patients with CRS in whom initial medical therapy failed who then self-selected continued medical management or surgical treatment was used to separate patients into 5 clusters based on a previously described discriminant analysis using total Sino-Nasal Outcome Test-22 (SNOT-22) score, age, and missed productivity. Patients completed the SNOT-22 at baseline and for 18 months of follow-up. Baseline demographic and objective measures included olfactory testing, computed tomography, and endoscopy scoring. SNOT-22 outcomes for surgical versus continued medical treatment were compared across clusters. Data were available on 690 patients. Baseline differences in demographics, comorbidities, objective disease measures, and patient-reported outcomes were similar to previous clustering reports. Three of 5 clusters identified by means of discriminant analysis had improved SNOT-22 outcomes with surgical intervention when compared with continued medical management (surgery was a mean of 21.2 points better across these 3 clusters at 6 months, P < .05). These differences were sustained at 18 months of follow-up. Two of 5 clusters had similar outcomes when comparing surgery with continued medical management. A simplified discriminant analysis based on 3 common clinical variables is able to cluster patients and provide prognostic information regarding surgical treatment versus continued medical management in patients with CRS. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  8. Numerical solution of a non-linear conservation law applicable to the interior dynamics of partially molten planets

    NASA Astrophysics Data System (ADS)

    Bower, Dan J.; Sanan, Patrick; Wolf, Aaron S.

    2018-01-01

    The energy balance of a partially molten rocky planet can be expressed as a non-linear diffusion equation using mixing length theory to quantify heat transport by both convection and mixing of the melt and solid phases. Crucially, in this formulation the effective or eddy diffusivity depends on the entropy gradient, ∂S / ∂r , as well as entropy itself. First we present a simplified model with semi-analytical solutions that highlights the large dynamic range of ∂S / ∂r -around 12 orders of magnitude-for physically-relevant parameters. It also elucidates the thermal structure of a magma ocean during the earliest stage of crystal formation. This motivates the development of a simple yet stable numerical scheme able to capture the large dynamic range of ∂S / ∂r and hence provide a flexible and robust method for time-integrating the energy equation. Using insight gained from the simplified model, we consider a full model, which includes energy fluxes associated with convection, mixing, gravitational separation, and conduction that all depend on the thermophysical properties of the melt and solid phases. This model is discretised and evolved by applying the finite volume method (FVM), allowing for extended precision calculations and using ∂S / ∂r as the solution variable. The FVM is well-suited to this problem since it is naturally energy conserving, flexible, and intuitive to incorporate arbitrary non-linear fluxes that rely on lookup data. Special attention is given to the numerically challenging scenario in which crystals first form in the centre of a magma ocean. The computational framework we devise is immediately applicable to modelling high melt fraction phenomena in Earth and planetary science research. Furthermore, it provides a template for solving similar non-linear diffusion equations that arise in other science and engineering disciplines, particularly for non-linear functional forms of the diffusion coefficient.

  9. 7 CFR 160.85 - Sale of mixed turpentine not lawful.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Sale of mixed turpentine not lawful. 160.85 Section 160.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) NAVAL STORES...

  10. 7 CFR 160.85 - Sale of mixed turpentine not lawful.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Sale of mixed turpentine not lawful. 160.85 Section 160.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) NAVAL STORES...

  11. runDM: Running couplings of Dark Matter to the Standard Model

    NASA Astrophysics Data System (ADS)

    D'Eramo, Francesco; Kavanagh, Bradley J.; Panci, Paolo

    2018-02-01

    runDM calculates the running of the couplings of Dark Matter (DM) to the Standard Model (SM) in simplified models with vector mediators. By specifying the mass of the mediator and the couplings of the mediator to SM fields at high energy, the code can calculate the couplings at low energy, taking into account the mixing of all dimension-6 operators. runDM can also extract the operator coefficients relevant for direct detection, namely low energy couplings to up, down and strange quarks and to protons and neutrons.

  12. A fluctuating quantum model of the CO vibration in carboxyhemoglobin.

    PubMed

    Falvo, Cyril; Meier, Christoph

    2011-06-07

    In this paper, we present a theoretical approach to construct a fluctuating quantum model of the CO vibration in heme-CO proteins and its interaction with external laser fields. The methodology consists of mixed quantum-classical calculations for a restricted number of snapshots, which are then used to construct a parametrized quantum model. As an example, we calculate the infrared absorption spectrum of carboxy-hemoglobin, based on a simplified protein model, and found the absorption linewidth in good agreement with the experimental results. © 2011 American Institute of Physics

  13. Progressive Damage Analyses of Skin/Stringer Debonding

    NASA Technical Reports Server (NTRS)

    Daville, Carlos G.; Camanho, Pedro P.; deMoura, Marcelo F.

    2004-01-01

    The debonding of skin/stringer constructions is analyzed using a step-by-step simulation of material degradation based on strain softening decohesion elements and a ply degradation procedure. Decohesion elements with mixed-mode capability are placed at the interface between the skin and the flange to simulate the initiation and propagation of the delamination. In addition, the initiation and accumulation of fiber failure and matrix damage is modeled using Hashin-type failure criteria and their corresponding material degradation schedules. The debonding predictions using simplified three-dimensional models correlate well with test results.

  14. Structural considerations for solar installers : an approach for small, simplified solar installations or retrofits.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Richards, Elizabeth H.; Schindel, Kay; Bosiljevac, Tom

    2011-12-01

    Structural Considerations for Solar Installers provides a comprehensive outline of structural considerations associated with simplified solar installations and recommends a set of best practices installers can follow when assessing such considerations. Information in the manual comes from engineering and solar experts as well as case studies. The objectives of the manual are to ensure safety and structural durability for rooftop solar installations and to potentially accelerate the permitting process by identifying and remedying structural issues prior to installation. The purpose of this document is to provide tools and guidelines for installers to help ensure that residential photovoltaic (PV) power systemsmore » are properly specified and installed with respect to the continuing structural integrity of the building.« less

  15. Calculation of the Full Scattering Amplitude without Partial Wave Decomposition. 2; Inclusion of Exchange

    NASA Technical Reports Server (NTRS)

    Shertzer, Janine; Temkin, Aaron

    2004-01-01

    The development of a practical method of accurately calculating the full scattering amplitude, without making a partial wave decomposition is continued. The method is developed in the context of electron-hydrogen scattering, and here exchange is dealt with by considering e-H scattering in the static exchange approximation. The Schroedinger equation in this approximation can be simplified to a set of coupled integro-differential equations. The equations are solved numerically for the full scattering wave function. The scattering amplitude can most accurately be calculated from an integral expression for the amplitude; that integral can be formally simplified, and then evaluated using the numerically determined wave function. The results are essentially identical to converged partial wave results.

  16. The Tuition/Financial Aid Equation and Its Impact on Access.

    ERIC Educational Resources Information Center

    Bowen, Raymond C.

    The complex rules and regulations of the student financial aid industry have alienated and confused both students and parents, especially those from lower income families. Unless simplified, the financial aid application process will continue to act as a deterrent to participation in the U.S. educational system. Families managing to overcome the…

  17. Continuous spin fields of mixed-symmetry type

    NASA Astrophysics Data System (ADS)

    Alkalaev, Konstantin; Grigoriev, Maxim

    2018-03-01

    We propose a description of continuous spin massless fields of mixed-symmetry type in Minkowski space at the level of equations of motion. It is based on the appropriately modified version of the constrained system originally used to describe massless bosonic fields of mixed-symmetry type. The description is shown to produce generalized versions of triplet, metric-like, and light-cone formulations. In particular, for scalar continuous spin fields we reproduce the Bekaert-Mourad formulation and the Schuster-Toro formulation. Because a continuous spin system inevitably involves infinite number of fields, specification of the allowed class of field configurations becomes a part of its definition. We show that the naive choice leads to an empty system and propose a suitable class resulting in the correct degrees of freedom. We also demonstrate that the gauge symmetries present in the formulation are all Stueckelberg-like so that the continuous spin system is not a genuine gauge theory.

  18. An Experiment Investigation of Fully-Modulated, Turbulent Diffusion Flames in Reduced Gravity

    NASA Technical Reports Server (NTRS)

    Hermanson, J. C.; Johari, H.; Usowicz, J. E.; Stocker, D. P.; Nagashima, T.; Obata, S.

    1999-01-01

    Pulsed combustion appears to have the potential to provide for rapid fuel/air mixing, compact and economical combustors, and reduced exhaust emissions. The ultimate objective of this program is to increase the fundamental understanding of the fuel/air mixing and combustion behavior of pulsed, turbulent diffusion flames by conducting experiments in microgravity. In this research the fuel jet is fully-modulated (i.e., completely shut off between pulses) by an externally controlled valve system. This can give rise to drastic modification of the combustion and flow characteristics of flames, leading to enhanced fuel/air mixing mechanisms not operative for the case of acoustically excited or partially-modulated jets. In addition, the fully-modulated injection approach avoids the strong acoustic forcing present in pulsed combustion devices, significantly simplifying the mixing and combustion processes. Relatively little is known of the behavior of turbulent flames in reduced-gravity conditions, even in the absence of pulsing. The goal of this Flight-Definition experiment (PUFF, for PUlsed-Fully Flames) is to establish the behavior of fully-modulated, turbulent diffusion flames under microgravity conditions. Fundamental issues to be addressed in this experiment include the mechanisms responsible for the flame length decrease for fully-modulated, turbulent diffusion flames compared with steady flames, the impact of buoyancy on the mixing and combustion characteristics of these flames, and the characteristics of turbulent flame puffs under fully momentum-dominated conditions.

  19. Applications of Analytical Self-Similar Solutions of Reynolds-Averaged Models for Instability-Induced Turbulent Mixing

    NASA Astrophysics Data System (ADS)

    Hartland, Tucker; Schilling, Oleg

    2017-11-01

    Analytical self-similar solutions to several families of single- and two-scale, eddy viscosity and Reynolds stress turbulence models are presented for Rayleigh-Taylor, Richtmyer-Meshkov, and Kelvin-Helmholtz instability-induced turbulent mixing. The use of algebraic relationships between model coefficients and physical observables (e.g., experimental growth rates) following from the self-similar solutions to calibrate a member of a given family of turbulence models is shown. It is demonstrated numerically that the algebraic relations accurately predict the value and variation of physical outputs of a Reynolds-averaged simulation in flow regimes that are consistent with the simplifying assumptions used to derive the solutions. The use of experimental and numerical simulation data on Reynolds stress anisotropy ratios to calibrate a Reynolds stress model is briefly illustrated. The implications of the analytical solutions for future Reynolds-averaged modeling of hydrodynamic instability-induced mixing are briefly discussed. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  20. Rich-burn, flame-assisted fuel cell, quick-mix, lean-burn (RFQL) combustor and power generation

    NASA Astrophysics Data System (ADS)

    Milcarek, Ryan J.; Ahn, Jeongmin

    2018-03-01

    Micro-tubular flame-assisted fuel cells (mT-FFC) were recently proposed as a modified version of the direct flame fuel cell (DFFC) operating in a dual chamber configuration. In this work, a rich-burn, quick-mix, lean-burn (RQL) combustor is combined with a micro-tubular solid oxide fuel cell (mT-SOFC) stack to create a rich-burn, flame-assisted fuel cell, quick-mix, lean-burn (RFQL) combustor and power generation system. The system is tested for rapid startup and achieves peak power densities after only 35 min of testing. The mT-FFC power density and voltage are affected by changes in the fuel-lean and fuel-rich combustion equivalence ratio. Optimal mT-FFC performance favors high fuel-rich equivalence ratios and a fuel-lean combustion equivalence ratio around 0.80. The electrical efficiency increases by 150% by using an intermediate temperature cathode material and improving the insulation. The RFQL combustor and power generation system achieves rapid startup, a simplified balance of plant and may have applications for reduced NOx formation and combined heat and power.

  1. Buoyancy Effects in Fully-Modulated, Turbulent Diffusion Flames

    NASA Technical Reports Server (NTRS)

    Hermanson, J. C.; Johari, H.; Ghaem-Maghami, E.; Stocker, D. P.; Hegde, U. G.; Page, K. L.

    2003-01-01

    Pulsed combustion appears to have the potential to provide for rapid fuel/air mixing, compact and economical combustors, and reduced exhaust emissions. The objective of this experiment (PuFF, for Pulsed-Fully Flames) is to increase the fundamental understanding of the fuel/air mixing and combustion behavior of pulsed, turbulent diffusion flames by conducting experiments in microgravity. In this research the fuel jet is fully-modulated (i.e., completely shut off between pulses) by an externally controlled valve system. This gives rise to drastic modification of the combustion and flow characteristics of flames, leading to enhanced fuel/air mixing compared to acoustically excited or partially-modulated jets. Normal-gravity experiments suggest that the fully-modulated technique also has the potential for producing turbulent jet flames significantly more compact than steady flames with no increase in exhaust emissions. The technique also simplifies the combustion process by avoiding the acoustic forcing generally present in pulsed combustors. Fundamental issues addressed in this experiment include the impact of buoyancy on the structure and flame length, temperatures, radiation, and emissions of fully-modulated flames.

  2. Transient Ejector Analysis (TEA) code user's guide

    NASA Technical Reports Server (NTRS)

    Drummond, Colin K.

    1993-01-01

    A FORTRAN computer program for the semi analytic prediction of unsteady thrust augmenting ejector performance has been developed, based on a theoretical analysis for ejectors. That analysis blends classic self-similar turbulent jet descriptions with control-volume mixing region elements. Division of the ejector into an inlet, diffuser, and mixing region allowed flexibility in the modeling of the physics for each region. In particular, the inlet and diffuser analyses are simplified by a quasi-steady-analysis, justified by the assumption that pressure is the forcing function in those regions. Only the mixing region is assumed to be dominated by viscous effects. The present work provides an overview of the code structure, a description of the required input and output data file formats, and the results for a test case. Since there are limitations to the code for applications outside the bounds of the test case, the user should consider TEA as a research code (not as a production code), designed specifically as an implementation of the proposed ejector theory. Program error flags are discussed, and some diagnostic routines are presented.

  3. Electric Field Generation and Control of Bipartite Quantum Entanglement between Electronic Spins in Mixed Valence Polyoxovanadate [GeV14O40]8.

    PubMed

    Palii, Andrew; Aldoshin, Sergey; Tsukerblat, Boris; Borràs-Almenar, Juan José; Clemente-Juan, Juan Modesto; Cardona-Serra, Salvador; Coronado, Eugenio

    2017-08-21

    As part of the search for systems in which control of quantum entanglement can be achieved, here we consider the paramagnetic mixed valence polyoxometalate K 2 Na 6 [GeV 14 O 40 ]·10H 2 O in which two electrons are delocalized over the 14 vanadium ions. Applying a homogeneous electric field can induce an antiferromagnetic coupling between the two delocalized electronic spins that behave independently in the absence of the field. On the basis of the proposed theoretical model, we show that the external field can be used to generate controllable quantum entanglement between the two electronic spins traveling over a vanadium network of mixed valence polyoxoanion [GeV 14 O 40 ] 8- . Within a simplified two-level picture of the energy pattern of the electronic pair based on the previous ab initio analysis, we evaluate the temperature and field dependencies of concurrence and thus indicate that the entanglement can be controlled via the temperature, magnitude, and orientation of the electric field with respect to molecular axes of [GeV 14 O 40 ] 8- .

  4. 12 CFR 268.302 - Mixed case complaints.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Mixed case complaints. 268.302 Section 268.302... (CONTINUED) RULES REGARDING EQUAL OPPORTUNITY Related Processes § 268.302 Mixed case complaints. A mixed case... discrimination or it may contain additional allegations that the MSPB has jurisdiction to address. A mixed case...

  5. 12 CFR 268.302 - Mixed case complaints.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Mixed case complaints. 268.302 Section 268.302... (CONTINUED) RULES REGARDING EQUAL OPPORTUNITY Related Processes § 268.302 Mixed case complaints. A mixed case... discrimination or it may contain additional allegations that the MSPB has jurisdiction to address. A mixed case...

  6. 12 CFR 268.302 - Mixed case complaints.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Mixed case complaints. 268.302 Section 268.302... (CONTINUED) RULES REGARDING EQUAL OPPORTUNITY Related Processes § 268.302 Mixed case complaints. A mixed case... discrimination or it may contain additional allegations that the MSPB has jurisdiction to address. A mixed case...

  7. Determination of the Shear Stress Distribution in a Laminate from the Applied Shear Resultant--A Simplified Shear Solution

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Aboudi, Jacob; Yarrington, Phillip W.

    2007-01-01

    The simplified shear solution method is presented for approximating the through-thickness shear stress distribution within a composite laminate based on laminated beam theory. The method does not consider the solution of a particular boundary value problem, rather it requires only knowledge of the global shear loading, geometry, and material properties of the laminate or panel. It is thus analogous to lamination theory in that ply level stresses can be efficiently determined from global load resultants (as determined, for instance, by finite element analysis) at a given location in a structure and used to evaluate the margin of safety on a ply by ply basis. The simplified shear solution stress distribution is zero at free surfaces, continuous at ply boundaries, and integrates to the applied shear load. Comparisons to existing theories are made for a variety of laminates, and design examples are provided illustrating the use of the method for determining through-thickness shear stress margins in several types of composite panels and in the context of a finite element structural analysis.

  8. Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating.

    PubMed

    Loeffler, Dirk; Wang, Weijia; Hopf, Alois; Hilsenbeck, Oliver; Bourgine, Paul E; Rudolf, Fabian; Martin, Ivan; Schroeder, Timm

    2018-03-29

    Keeping track of individual cell identifications is imperative to the study of dynamic single-cell behavior over time. Highly motile hematopoietic stem and progenitor cells (HSPCs) migrate quickly and do not adhere, and thus must be imaged very frequently to keep cell identifications. Even worse, they are also flushed away during medium exchange. To overcome these limitations, we tested antibody coating for reducing HSPC motility in vitro. Anti-CD43- and anti-CD44-antibody coating reduced the cell motility of mouse and human HSPCs in a concentration-dependent manner. This enables 2-dimensional (2D) colony formation without cell mixing in liquid cultures, massively increases time-lapse imaging throughput, and also maintains cell positions during media exchange. Anti-CD43 but not anti-CD44 coating reduces mouse HSPC proliferation with increasing concentrations. No relevant effects on cell survival or myeloid and megakaryocyte differentiation of hematopoietic stem cells and multipotent progenitors 1-5 were detected. Human umbilical cord hematopoietic CD34 + cell survival, proliferation, and differentiation were not affected by either coating. This approach both massively simplifies and accelerates continuous analysis of suspension cells, and enables the study of their behavior in dynamic rather than static culture conditions over time. © 2018 by The American Society of Hematology.

  9. Modifications of a Device for Maintenance of the Rumen Microbial Population in Continuous Culture

    PubMed Central

    Slyter, L. L.; Nelson, W. O.; Wolin, M. J.

    1964-01-01

    An improved and simplified apparatus for maintaining the rumen microbial population in continuous culture was constructed. All components were easily obtained from commercial sources or were simple to construct. Mechanical difficulties were minimal, and little attention was needed on the part of the operator. The deoxyribonucleic acid (DNA) content of the cultures (100 to 150 μg/ml) varied little during 7 days of continuous culture, and protozoal concentration decreased from 105 per ml to a steady-state level of 2 × 103 per ml in 4 days. Volatile fatty acid and methane production followed the normal in vivo pattern for 7 days of continuous culture. DNA, protozoal concentrations, and fermentation patterns did not significantly change between 4 and 21 days of continuous culture. PMID:14201093

  10. 40 CFR 266.220 - What does a storage and treatment conditional exemption do?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Conditional Exemption for Low-Level Mixed Waste Storage... exemption exempts your low-level mixed waste from the regulatory definition of hazardous waste in 40 CFR 261...

  11. A Bayesian Semiparametric Latent Variable Model for Mixed Responses

    ERIC Educational Resources Information Center

    Fahrmeir, Ludwig; Raach, Alexander

    2007-01-01

    In this paper we introduce a latent variable model (LVM) for mixed ordinal and continuous responses, where covariate effects on the continuous latent variables are modelled through a flexible semiparametric Gaussian regression model. We extend existing LVMs with the usual linear covariate effects by including nonparametric components for nonlinear…

  12. Impact of computerized order entry and pre-mixed dialysis solutions for continuous veno-venous hemodiafiltration on selection of therapy for acute renal failure.

    PubMed

    Saadulla, Lawand; Reeves, W Brian; Irey, Brittany; Ghahramani, Nasrollah

    2012-02-01

    To investigate the impacts of availability of pre-mixed solutions and computerized order entry on nephrologists' choice of the initial mode of renal replacement therapy in acute renal failure. We studied 898 patients with acute renal failure in 3 consecutive eras: era 1 (custom-mixed solution; n = 309), era 2 (pre-mixed commercial solution; n = 324), and era 3 (post-computerized order entry; n = 265). The proportion of patients treated with renal replacement therapy and the time from consult to initiation of continuous renal replacement therapy was similar in the 3 eras. Following introduction of the pre-mixed solution, the proportion of patients treated with continuous renal replacement therapy increased (20% vs. 33%; p < 0.05), it was initiated at a lower serum creatinine (353 ± 123 μmol/L vs. 300 ± 80 μmol/L; p < 0.05) and in older patients (53 ± 12 vs. 61 ± 14 years; p < 0.05). There was a progressive increase in the use of continuous veno-venous hemodialysis (18% vs. 79% vs. 100%; p < 0.05) and in the total prescribed flow rate (1,382 ± 546 vs. 2,324 ± 737 vs. 2,900 ± 305 mL/hr 3; p < 0.05). There was no significant impact on mortality. The availability of a pre-mixed solution increases the likelihood of initiating continuous renal replacement therapy in acute renal failure, initiating it at a lower creatinine and for older patients, use of continuous veno-venous hemodialysis and higher prescribed continuous renal replacement therapy dose. Computerized order entry implementation is associated with an additional increase in the use of continuous veno-venous hemodialysis, higher total prescribed dialysis dose, and use of CRRT among an increasing number of patients not on mechanical ventilation. The effect of these changes on patient survival is not significant.

  13. Covariant diagrams for one-loop matching

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Zhengkang

    Here, we present a diagrammatic formulation of recently-revived covariant functional approaches to one-loop matching from an ultraviolet (UV) theory to a low-energy effective field theory. Various terms following from a covariant derivative expansion (CDE) are represented by diagrams which, unlike conventional Feynman diagrams, involve gauge-covariant quantities and are thus dubbed "covariant diagrams." The use of covariant diagrams helps organize and simplify one-loop matching calculations, which we illustrate with examples. Of particular interest is the derivation of UV model-independent universal results, which reduce matching calculations of specific UV models to applications of master formulas. We also show how such derivation canmore » be done in a more concise manner than the previous literature, and discuss how additional structures that are not directly captured by existing universal results, including mixed heavy-light loops, open covariant derivatives, and mixed statistics, can be easily accounted for.« less

  14. Covariant diagrams for one-loop matching

    DOE PAGES

    Zhang, Zhengkang

    2017-05-30

    Here, we present a diagrammatic formulation of recently-revived covariant functional approaches to one-loop matching from an ultraviolet (UV) theory to a low-energy effective field theory. Various terms following from a covariant derivative expansion (CDE) are represented by diagrams which, unlike conventional Feynman diagrams, involve gauge-covariant quantities and are thus dubbed "covariant diagrams." The use of covariant diagrams helps organize and simplify one-loop matching calculations, which we illustrate with examples. Of particular interest is the derivation of UV model-independent universal results, which reduce matching calculations of specific UV models to applications of master formulas. We also show how such derivation canmore » be done in a more concise manner than the previous literature, and discuss how additional structures that are not directly captured by existing universal results, including mixed heavy-light loops, open covariant derivatives, and mixed statistics, can be easily accounted for.« less

  15. The very low frequency power spectrum of Centaurus X-3

    NASA Technical Reports Server (NTRS)

    Gruber, D. E.

    1988-01-01

    The long-term variability of Cen X-3 on time scales ranging from days to years has been examined by combining data obtained by the HEAO 1 A-4 instrument with data from Vela 5B. A simple interpretation of the data is made in terms of the standard alpha-disk model of accretion disk structure and dynamics. Assuming that the low-frequency variance represents the inherent variability of the mass transfer from the companion, the decline in power at higher frequencies results from the leveling of radial structure in the accretion disk through viscous mixing. The shape of the observed power spectrum is shown to be in excellent agreement with a calculation based on a simplified form of this model. The observed low-frequency power spectrum of Cen X-3 is consistent with a disk in which viscous mixing occurs about as rapidly as possible and on the largest scale possible.

  16. Hybrid multiphase CFD simulation for liquid-liquid interfacial area prediction in annular centrifugal contactors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wardle, K.E.

    2013-07-01

    Liquid-liquid contacting equipment used in solvent extraction processes has the dual purpose of mixing and separating two immiscible fluids. Consequently, such devices inherently encompass a wide variety of multiphase flow regimes. A hybrid multiphase computational fluid dynamics (CFD) solver which combines the Eulerian multi-fluid method with VOF (volume of fluid) sharp interface capturing has been developed for application to annular centrifugal contactors. This solver has been extended to enable prediction of mean droplet size and liquid-liquid interfacial area through a single moment population balance method. Simulations of liquid-liquid mixing in a simplified geometry and a model annular centrifugal contactor aremore » reported with droplet breakup/coalescence models being calibrated versus available experimental data. Quantitative comparison is made for two different housing vane geometries and it is found that the predicted droplet size is significantly smaller for vane geometries which result in higher annular liquid holdup.« less

  17. Hunting Down Massless Dark Photons in Kaon Physics

    NASA Astrophysics Data System (ADS)

    Fabbrichesi, M.; Gabrielli, E.; Mele, B.

    2017-07-01

    If dark photons are massless, they couple to standard-model particles only via higher dimensional operators, while direct (renormalizable) interactions induced by kinetic mixing, which motivates most of the current experimental searches, are absent. We consider the effect of possible flavor-changing magnetic-dipole couplings of massless dark photons in kaon physics. In particular, we study the branching ratio for the process K+→π+π0γ ¯ with a simplified-model approach, assuming the chiral quark model to evaluate the hadronic matrix element. Possible effects in the K0-K¯ 0 mixing are taken into account. We find that branching ratios up to O (10-7) are allowed—depending on the dark-sector masses and couplings. Such large branching ratios for K+→π+π0γ ¯ could be of interest for experiments dedicated to rare K+ decays like NA62 at CERN, where γ ¯ can be detected as a massless invisible system.

  18. A microfluidic galvanic cell on a single layer of paper

    NASA Astrophysics Data System (ADS)

    Purohit, Krutarth H.; Emrani, Saina; Rodriguez, Sandra; Liaw, Shi-Shen; Pham, Linda; Galvan, Vicente; Domalaon, Kryls; Gomez, Frank A.; Haan, John L.

    2016-06-01

    Paper microfluidics is used to produce single layer galvanic and hybrid cells to produce energy that could power paper-based analytical sensors. When two aqueous streams are absorbed onto paper to establish co-laminar flow, the streams stay in contact with each other with limited mixing. The interface at which mixing occurs acts as a charge-transfer region, eliminating the need for a salt bridge. We designed a Cusbnd Zn galvanic cell that powers an LED when two are placed in series. We also used more powerful redox couples (formate and silver, formate and permanganate) to produce higher power density (18 and 3.1 mW mg-1 Pd). These power densities are greater than previously reported paper microfluidic fuel cells using formate or methanol. The single layer design is much more simplified than previous reports of multi-layer galvanic cells on paper.

  19. Novel phased isolation ditch system for enhanced nutrient removal and its optimal operating strategy.

    PubMed

    Hong, K i-Ho; Chang, Duk; Hur, Joon-Moo; Han, Sang-Bae

    2003-01-01

    Phased isolation ditch system with intrachannel clarifier is a simplified novel oxidation ditch system enhancing simultaneous removal of biological nitrogen and phosphorus in municipal wastewater. The system employs two ditches with intra-clarifier, and eliminates external final clarifier, additional preanaerobic reactor, and recycle of sludge and nitrified effluent. Separation of anoxic, anaerobic, and aerobic phases can be accomplished by alternating flow and intermittent aeration. Its pilot-scale system operated at HRTs of 10-21 h, SRTs of 15-41 days, and a cycle times of 2-8 h showed removals of BOD, TN, and TP in the range of mixed liquor temperature above 10 degrees C as high as 88-97, 70-84, and 65-90%, respectively. As the SRTs became longer, the effluent TN decreased dramatically, whereas the effluent TP increased. Higher nitrogen removal was accomplished at shorter cycle times, while better phosphorus removal was achieved in longer cycle times. Optimal system operating strategies maximizing the performance and satisfying both the best nitrogen and phosphorus removals included HRTs ranged 10-14 h, SRTs ranged 25-30 days, and a cycle time of 4 h at the mixed liquor temperature above 10 degrees C. Thus, complete phase separation in a cycle maximizing phosphorus release and uptake as well as nitrification and denitrification was accomplished by scheduling of alternating flow and intermittent aeration in the simplified process scheme. Especially, temporal phase separation for phosphorus release without additional anaerobic reactor was successfully accomplished during anaerobic period without any nitrate interference and carbon-limiting.

  20. Continuous-spin mixed-symmetry fields in AdS(5)

    NASA Astrophysics Data System (ADS)

    Metsaev, R. R.

    2018-05-01

    Free mixed-symmetry continuous-spin fields propagating in AdS(5) space and flat R(4,1) space are studied. In the framework of a light-cone gauge formulation of relativistic dynamics, we build simple actions for such fields. The realization of relativistic symmetries on the space of light-cone gauge mixed-symmetry continuous-spin fields is also found. Interrelations between constant parameters entering the light-cone gauge actions and eigenvalues of the Casimir operators of space-time symmetry algebras are obtained. Using these interrelations and requiring that the field dynamics in AdS(5) be irreducible and classically unitary, we derive restrictions on the constant parameters and eigenvalues of the second-order Casimir operator of the algebra.

  1. Process for blending coal with water immiscible liquid

    DOEpatents

    Heavin, Leonard J.; King, Edward E.; Milliron, Dennis L.

    1982-10-26

    A continuous process for blending coal with a water immiscible liquid produces a uniform, pumpable slurry. Pulverized raw feed coal and preferably a coal derived, water immiscible liquid are continuously fed to a blending zone (12 and 18) in which coal particles and liquid are intimately admixed and advanced in substantially plug flow to form a first slurry. The first slurry is withdrawn from the blending zone (12 and 18) and fed to a mixing zone (24) where it is mixed with a hot slurry to form the pumpable slurry. A portion of the pumpable slurry is continuously recycled to the blending zone (12 and 18) for mixing with the feed coal.

  2. Simulation of air-droplet mixed phase flow in icing wind-tunnel

    NASA Astrophysics Data System (ADS)

    Mengyao, Leng; Shinan, Chang; Menglong, Wu; Yunhang, Li

    2013-07-01

    Icing wind-tunnel is the main ground facility for the research of aircraft icing, which is different from normal wind-tunnel for its refrigeration system and spraying system. In stable section of icing wind-tunnel, the original parameters of droplets and air are different, for example, to keep the nozzles from freezing, the droplets are heated while the temperature of air is low. It means that complex mass and heat transfer as well as dynamic interactive force would happen between droplets and air, and the parameters of droplet will acutely change along the passageway. Therefore, the prediction of droplet-air mixed phase flow is necessary in the evaluation of icing researching wind-tunnel. In this paper, a simplified droplet-air mixed phase flow model based on Lagrangian method was built. The variation of temperature, diameter and velocity of droplet, as well as the air flow field, during the flow process were obtained under different condition. With calculating three-dimensional air flow field by FLUENT, the droplet could be traced and the droplet distribution could also be achieved. Furthermore, the patterns about how initial parameters affect the parameters in test section were achieved. The numerical simulation solving the flow and heat and mass transfer characteristics in the mixing process is valuable for the optimization of experimental parameters design and equipment adjustment.

  3. Apparatus and method for continuous production of materials

    DOEpatents

    Chang, Chih-hung; Jin, Hyungdae

    2014-08-12

    Embodiments of a continuous-flow injection reactor and a method for continuous material synthesis are disclosed. The reactor includes a mixing zone unit and a residence time unit removably coupled to the mixing zone unit. The mixing zone unit includes at least one top inlet, a side inlet, and a bottom outlet. An injection tube, or plurality of injection tubes, is inserted through the top inlet and extends past the side inlet while terminating above the bottom outlet. A first reactant solution flows in through the side inlet, and a second reactant solution flows in through the injection tube(s). With reference to nanoparticle synthesis, the reactant solutions combine in a mixing zone and form nucleated nanoparticles. The nucleated nanoparticles flow through the residence time unit. The residence time unit may be a single conduit, or it may include an outer housing and a plurality of inner tubes within the outer housing.

  4. Simplified HCC-ART score for highly sensitive detection of small-sized and early-stage hepatocellular carcinoma in the widely used Okuda, CLIP, and BCLC staging systems.

    PubMed

    Attallah, Abdelfattah M; Omran, Mohamed M; Attallah, Ahmed A; Abdelrazek, Mohamed A; Farid, Khaled; El-Dosoky, Ibrahim

    2017-04-01

    Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC. Different HCC-ART cutoffs were set for the detection of different tumor sizes. The HCC-ART (AUC = 0.871, 70% sensitivity, 97% specificity) and the simplified HCC-ART (AUC = 0.934, 82% sensitivity, 100% specificity) were found to have high predictive power when attempting to separate cirrhotic patients from those with small-sized HCC. The simplified HCC-ART score was superior to AFP for determining stages according to the early Okuda (0.950 AUC, 84% sensitivity, 99% specificity), CLIP (0.945 AUC, 84% sensitivity, 99% specificity), and BCLC (1.000 AUC, 100% sensitivity, 99% specificity) staging systems. The simplified HCC-ART score was more strongly correlated than AFP and other staging systems with HCC tumor size (P < 0.0001; r = 0.8). The HCC-ART is superior to AFP for diagnosing early-stage HCC. Due to its advantages of minimal variability and a wide continuous scale for assessing HCC severity, the simplified HCC-ART has the potential to be more widely used than the original HCC-ART.

  5. Random walk, diffusion and mixing in simulations of scalar transport in fluid flows

    NASA Astrophysics Data System (ADS)

    Klimenko, A. Y.

    2008-12-01

    Physical similarity and mathematical equivalence of continuous diffusion and particle random walk form one of the cornerstones of modern physics and the theory of stochastic processes. In many applied models used in simulation of turbulent transport and turbulent combustion, mixing between particles is used to reflect the influence of the continuous diffusion terms in the transport equations. We show that the continuous scalar transport and diffusion can be accurately specified by means of mixing between randomly walking Lagrangian particles with scalar properties and assess errors associated with this scheme. This gives an alternative formulation for the stochastic process which is selected to represent the continuous diffusion. This paper focuses on statistical errors and deals with relatively simple cases, where one-particle distributions are sufficient for a complete description of the problem.

  6. Continuous determination of gaseous ammonia in the ambient atmosphere using fluorescence derivatization

    NASA Astrophysics Data System (ADS)

    Abbas, Rana; Tanner, Roger L.

    A method for continuous determination of ambient ammonia levels employing o-phthalaldehyde fluorescence derivatization is described. A simplified Venturi scrubber and gas-liquid separator have been employed for reproducible measurements of ⩾ 0.1 ppb ambient ammonia with less than 2 min time resolution. The scrubbing efficiency of the ammonia gas collection system was determined to be 29 ± 1 %. During 4 d in August 1979 ambient ammonia levels at the Brookhaven National Laboratory site averaged about 1.5 ± 1.1 ppb during afternoon daylight hours.

  7. Teaching the Research Paper through Inquiry-Based Instruction

    ERIC Educational Resources Information Center

    Zeek, Sara

    2011-01-01

    The freshman research paper can be a labor for both the teacher and the student with its many layers of skills and expectations. While academia has moved beyond note cards and simplified documentation models, students continue to get lost in the research process, often to the point that instructors may even wonder if they had been teaching in an…

  8. Sex Stereotyping Versus Perceived Value as the Mediator of Sex Differentiated Math Participation.

    ERIC Educational Resources Information Center

    Parsons, Jacquelynne Eccles

    Students' stereotyping of mathematics as a male domain and their ratings of themselves on a simplified version of the PAQ was correlated with a battery of measures designed to assess student attitudes toward mathematics and their plans to continue taking mathematics courses. This was done to evaluate both sex-typed personality characteristics and…

  9. 7 CFR 58.638 - Freezing the mix.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Freezing the mix. 58.638 Section 58.638 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.638 Freezing the mix. After the mix enters the freezer, it shall be frozen as rapidly as...

  10. 7 CFR 58.638 - Freezing the mix.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Freezing the mix. 58.638 Section 58.638 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.638 Freezing the mix. After the mix enters the freezer, it shall be frozen as rapidly as...

  11. 7 CFR 810.801 - Definition of mixed grain.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Definition of mixed grain. 810.801 Section 810.801 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... GRAIN United States Standards for Mixed Grain Terms Defined § 810.801 Definition of mixed grain. Any...

  12. 7 CFR 58.638 - Freezing the mix.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Freezing the mix. 58.638 Section 58.638 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.638 Freezing the mix. After the mix enters the freezer, it shall be frozen as rapidly as...

  13. 7 CFR 58.637 - Cooling the mix.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Cooling the mix. 58.637 Section 58.637 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.637 Cooling the mix. The mix shall be immediately cooled to a temperature of 45 °F. or lower...

  14. 7 CFR 810.801 - Definition of mixed grain.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Definition of mixed grain. 810.801 Section 810.801 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... GRAIN United States Standards for Mixed Grain Terms Defined § 810.801 Definition of mixed grain. Any...

  15. 7 CFR 810.801 - Definition of mixed grain.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Definition of mixed grain. 810.801 Section 810.801 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... GRAIN United States Standards for Mixed Grain Terms Defined § 810.801 Definition of mixed grain. Any...

  16. 7 CFR 58.635 - Pasteurization of the mix.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Pasteurization of the mix. 58.635 Section 58.635 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.635 Pasteurization of the mix. Every particle of the mix, except added flavoring ingredients...

  17. 7 CFR 58.637 - Cooling the mix.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Cooling the mix. 58.637 Section 58.637 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.637 Cooling the mix. The mix shall be immediately cooled to a temperature of 45 °F. or lower...

  18. 7 CFR 58.637 - Cooling the mix.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Cooling the mix. 58.637 Section 58.637 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.637 Cooling the mix. The mix shall be immediately cooled to a temperature of 45 °F. or lower...

  19. 7 CFR 58.635 - Pasteurization of the mix.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Pasteurization of the mix. 58.635 Section 58.635 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.635 Pasteurization of the mix. Every particle of the mix, except added flavoring ingredients...

  20. 7 CFR 810.801 - Definition of mixed grain.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Definition of mixed grain. 810.801 Section 810.801 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... GRAIN United States Standards for Mixed Grain Terms Defined § 810.801 Definition of mixed grain. Any...

  1. 7 CFR 58.635 - Pasteurization of the mix.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Pasteurization of the mix. 58.635 Section 58.635 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Procedures § 58.635 Pasteurization of the mix. Every particle of the mix, except added flavoring ingredients...

  2. 7 CFR 810.801 - Definition of mixed grain.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Definition of mixed grain. 810.801 Section 810.801 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... GRAIN United States Standards for Mixed Grain Terms Defined § 810.801 Definition of mixed grain. Any...

  3. Emerald: an object-based language for distributed programming

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hutchinson, N.C.

    1987-01-01

    Distributed systems have become more common, however constructing distributed applications remains a very difficult task. Numerous operating systems and programming languages have been proposed that attempt to simplify the programming of distributed applications. Here a programing language called Emerald is presented that simplifies distributed programming by extending the concepts of object-based languages to the distributed environment. Emerald supports a single model of computation: the object. Emerald objects include private entities such as integers and Booleans, as well as shared, distributed entities such as compilers, directories, and entire file systems. Emerald objects may move between machines in the system, but objectmore » invocation is location independent. The uniform semantic model used for describing all Emerald objects makes the construction of distributed applications in Emerald much simpler than in systems where the differences in implementation between local and remote entities are visible in the language semantics. Emerald incorporates a type system that deals only with the specification of objects - ignoring differences in implementation. Thus, two different implementations of the same abstraction may be freely mixed.« less

  4. ☆DNA assembly technique simplifies the construction of infectious clone of fowl adenovirus.

    PubMed

    Zou, Xiao-Hui; Bi, Zhi-Xiang; Guo, Xiao-Juan; Zhang, Zun; Zhao, Yang; Wang, Min; Zhu, Ya-Lu; Jie, Hong-Ying; Yu, Yang; Hung, Tao; Lu, Zhuo-Zhuang

    2018-07-01

    Plasmid bearing adenovirus genome is generally constructed with the method of homologous recombination in E. coli BJ5183 strain. Here, we utilized Gibson gene assembly technique to generate infectious clone of fowl adenovirus 4 (FAdV-4). Primers flanked with partial inverted terminal repeat (ITR) sequence of FAdV-4 were synthesized to amplify a plasmid backbone containing kanamycin-resistant gene and pBR322 origin (KAN-ORI). DNA assembly was carried out by combining the KAN-ORI fragment, virus genomic DNA and DNA assembly master mix. E. coli competent cells were transformed with the assembled product, and plasmids (pKFAV4) were extracted and confirmed to contain viral genome by restriction analysis and sequencing. Virus was successfully rescued from linear pKFAV4-transfected chicken LMH cells. This approach was further verified in cloning of human adenovirus 5 genome. Our results indicated that DNA assembly technique simplified the construction of infectious clone of adenovirus, suggesting its possible application in virus traditional or reverse genetics. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Computational study of single-expansion-ramp nozzles with external burning

    NASA Astrophysics Data System (ADS)

    Yungster, Shaye; Trefny, Charles J.

    1992-04-01

    A computational investigation of the effects of external burning on the performance of single expansion ramp nozzles (SERN) operating at transonic speeds is presented. The study focuses on the effects of external heat addition and introduces a simplified injection and mixing model based on a control volume analysis. This simplified model permits parametric and scaling studies that would have been impossible to conduct with a detailed CFD analysis. The CFD model is validated by comparing the computed pressure distribution and thrust forces, for several nozzle configurations, with experimental data. Specific impulse calculations are also presented which indicate that external burning performance can be superior to other methods of thrust augmentation at transonic speeds. The effects of injection fuel pressure and nozzle pressure ratio on the performance of SERN nozzles with external burning are described. The results show trends similar to those reported in the experimental study, and provide additional information that complements the experimental data, improving our understanding of external burning flowfields. A study of the effect of scale is also presented. The results indicate that combustion kinetics do not make the flowfield sensitive to scale.

  6. Environmental and human monitoring of Americium-241 utilizing extraction chromatography and {alpha}-Spectrometry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goldstein, S.J.; Hensley, C.A.; Armenta, C.E.

    1997-03-01

    Recent developments in extraction chromatography have simplified the separation of americium from complex matrices in preparation for {alpha}-spectroscopy relative to traditional methods. Here we present results of procedures developed/adapted for water, air, and bioassay samples with less than 1 g of inorganic residue. Prior analytical methods required the use of a complex, multistage procedure for separation of americium from these matrices. The newer, simplified procedure requires only a single 2 mL extraction chromatographic separation for isolation of Am and lanthanides from other components of the sample. This method has been implemented on an extensive variety of `real` environmental and bioassaymore » samples from the Los Alamos area, and consistently reliable and accurate results with appropriate detection limits have been obtained. The new method increases analytical throughput by a factor of {approx}2 and decreases environmental hazards from acid and mixed-waste generation relative to the prior technique. Analytical accuracy, reproducibility, and reliability are also significantly improved over the more complex and laborious method used previously. 24 refs., 2 figs., 2 tabs.« less

  7. Computational study of single-expansion-ramp nozzles with external burning

    NASA Technical Reports Server (NTRS)

    Yungster, Shaye; Trefny, Charles J.

    1992-01-01

    A computational investigation of the effects of external burning on the performance of single expansion ramp nozzles (SERN) operating at transonic speeds is presented. The study focuses on the effects of external heat addition and introduces a simplified injection and mixing model based on a control volume analysis. This simplified model permits parametric and scaling studies that would have been impossible to conduct with a detailed CFD analysis. The CFD model is validated by comparing the computed pressure distribution and thrust forces, for several nozzle configurations, with experimental data. Specific impulse calculations are also presented which indicate that external burning performance can be superior to other methods of thrust augmentation at transonic speeds. The effects of injection fuel pressure and nozzle pressure ratio on the performance of SERN nozzles with external burning are described. The results show trends similar to those reported in the experimental study, and provide additional information that complements the experimental data, improving our understanding of external burning flowfields. A study of the effect of scale is also presented. The results indicate that combustion kinetics do not make the flowfield sensitive to scale.

  8. Soft-output decoding algorithms in iterative decoding of turbo codes

    NASA Technical Reports Server (NTRS)

    Benedetto, S.; Montorsi, G.; Divsalar, D.; Pollara, F.

    1996-01-01

    In this article, we present two versions of a simplified maximum a posteriori decoding algorithm. The algorithms work in a sliding window form, like the Viterbi algorithm, and can thus be used to decode continuously transmitted sequences obtained by parallel concatenated codes, without requiring code trellis termination. A heuristic explanation is also given of how to embed the maximum a posteriori algorithms into the iterative decoding of parallel concatenated codes (turbo codes). The performances of the two algorithms are compared on the basis of a powerful rate 1/3 parallel concatenated code. Basic circuits to implement the simplified a posteriori decoding algorithm using lookup tables, and two further approximations (linear and threshold), with a very small penalty, to eliminate the need for lookup tables are proposed.

  9. 40 CFR 439.41 - Special definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STANDARDS (CONTINUED) PHARMACEUTICAL MANUFACTURING POINT SOURCE CATEGORY Mixing/Compounding and Formulation § 439.41 Special definitions. For the purpose of this subpart: (a) Mixing, compounding, and formulating... pharmaceutical product manufactured by blending, mixing, compounding, and formulating pharmaceutical ingredients...

  10. Foundations of chaotic mixing.

    PubMed

    Wiggins, Stephen; Ottino, Julio M

    2004-05-15

    The simplest mixing problem corresponds to the mixing of a fluid with itself; this case provides a foundation on which the subject rests. The objective here is to study mixing independently of the mechanisms used to create the motion and review elements of theory focusing mostly on mathematical foundations and minimal models. The flows under consideration will be of two types: two-dimensional (2D) 'blinking flows', or three-dimensional (3D) duct flows. Given that mixing in continuous 3D duct flows depends critically on cross-sectional mixing, and that many microfluidic applications involve continuous flows, we focus on the essential aspects of mixing in 2D flows, as they provide a foundation from which to base our understanding of more complex cases. The baker's transformation is taken as the centrepiece for describing the dynamical systems framework. In particular, a hierarchy of characterizations of mixing exist, Bernoulli --> mixing --> ergodic, ordered according to the quality of mixing (the strongest first). Most importantly for the design process, we show how the so-called linked twist maps function as a minimal picture of mixing, provide a mathematical structure for understanding the type of 2D flows that arise in many micromixers already built, and give conditions guaranteeing the best quality mixing. Extensions of these concepts lead to first-principle-based designs without resorting to lengthy computations.

  11. [Design and Optimization of Microfluidic Chips Used for Mixing Cryoprotectants].

    PubMed

    Zhou, Xinli; Yi, Xingyue; Zhou, Nanfeng; Yang, Yun

    2016-06-01

    Microfluidic chips can be used to realize continuous cryoprotectants(CPA)loading/unloading for oocytes,reducing osmotic damage and chemical toxicity of CPA.In this study,five different Y-shape microfluidic chips were fabricated to realize the continuous CPA loading/unloading.The effects of flow rate,entrance angle,aspect ratio and turning radius of microchannels on the mixing efficiency of microfluidic chips were analyzed quantitatively.The experimental results showed that with the decrease of flow rates,the increase of aspect ratios and the decrease of turning raradius of microchannel,the mixing length decreased and the mixing velocity was promoted,while the entrance angle had little effect on the mixing efficiency.However,the operating conditions and structural parameters of the chips in practical application should be determined based on an overall consideration of CPA loading/unloading time and machining accuracy.These results would provide a reference to the application of microfluidic chip in CPA mixing.

  12. Effects of e-Learning and m-Learning on Nursing Care in a Continuing Education Context: An Overview of Mixed Method Systematic Reviews (Protocol).

    PubMed

    Rouleau, Geneviève; Gagnon, Marie-Pierre; Côté, José; Hudson, Emilie; Payne-Gagnon, Julie; Bouix-Picasso, Julien; Duboi, Carl-Ardy

    2017-01-01

    Continuing education is an imperative for professional nursing. e-Learning is one modality to support education and it has been extensively examined in a nursing academic context. An overview of quantitative, qualitative, and mixed-method systematic reviews were conducted to draw a broad picture of the effects of e-Learning and m-Learning used by registered nurses in a continuing education context.

  13. The development of mixer machine for organic animal feed production: Proposed study

    NASA Astrophysics Data System (ADS)

    Leman, A. M.; Wahab, R. Abdul; Zakaria, Supaat; Feriyanto, Dafit; Nor, M. I. F. Che Mohd; Muzarpar, Syafiq

    2017-09-01

    Mixer machine plays a major role in producing homogenous composition of animal feed. Long time production, inhomogeneous and minor agglomeration has been observed by existing mixer. Therefore, this paper proposed continuous mixer to enhance mixing efficiency with shorter time of mixing process in order to abbreviate the whole process in animal feed production. Through calculation of torque, torsion, bending, power and energy consumption will perform in mixer machine process. Proposed mixer machine is designed by two layer buckets with purpose for continuity of mixing process. Mixing process was performed by 4 blades which consists of various arm length such as 50, 100,150 and 225 mm in 60 rpm velocity clockwise rotation. Therefore by using this machine will produce the homogenous composition of animal feed through nutrition analysis and short operation time of mixing process approximately of 5 minutes. Therefore, the production of animal feed will suitable for various animals including poultry and aquatic fish. This mixer will available for various organic material in animal feed production. Therefore, this paper will highlights some areas such as continues animal feed supply chain and bio-based animal feed.

  14. Mixing-controlled uncertainty in long-term predictions of acid rock drainage from heterogeneous waste-rock piles

    NASA Astrophysics Data System (ADS)

    Pedretti, D.; Beckie, R. D.; Mayer, K. U.

    2015-12-01

    The chemistry of drainage from waste-rock piles at mine sites is difficult to predict because of a number of uncertainties including heterogeneous reactive mineral content, distribution of minerals, weathering rates and physical flow properties. In this presentation, we examine the effects of mixing on drainage chemistry over timescales of 100s of years. We use a 1-D streamtube conceptualization of flow in waste rocks and multicomponent reactive transport modeling. We simplify the reactive system to consist of acid-producing sulfide minerals and acid-neutralizing carbonate minerals and secondary sulfate and iron oxide minerals. We create multiple realizations of waste-rock piles with distinct distributions of reactive minerals along each flow path and examine the uncertainty of drainage geochemistry through time. The limited mixing of streamtubes that is characteristic of the vertical unsaturated flow in many waste-rock piles, allows individual flowpaths to sustain acid or neutral conditions to the base of the pile, where the streamtubes mix. Consequently, mixing and the acidity/alkalinity balance of the streamtube waters, and not the overall acid- and base-producing mineral contents, control the instantaneous discharge chemistry. Our results show that the limited mixing implied by preferential flow and the heterogeneous distribution of mineral contents lead to large uncertainty in drainage chemistry over short and medium time scales. However, over longer timescales when one of either the acid-producing or neutralizing primary phases is depleted, the drainage chemistry becomes less controlled by mixing and in turn less uncertain. A correct understanding of the temporal variability of uncertainty is key to make informed long-term decisions in mining settings regarding the management of waste material.

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Speetjens, M. F. M.; Demissie, E. A.; Metcalfe, G.

    Laminar mixing by the inline-mixing principle is a key to many industrial fluids-engineering systems of size extending from micrometers to meters. However, insight into fundamental transport phenomena particularly under the realistic conditions of three-dimensionality (3D) and fluid inertia remains limited. This study addresses these issues for inline mixers with cylindrical geometries and adopts the Rotated Arc Mixer (RAM) as a representative system. Transport is investigated from a Lagrangian perspective by identifying and examining coherent structures that form in the 3D streamline portrait. 3D effects and fluid inertia introduce three key features that are not found in simplified configurations: transition zonesmore » between consecutive mixing cells of the inline-mixing flow; local upstream flow (in certain parameter regimes); transition/inertia-induced breaking of symmetries in the Lagrangian equations of motion (causing topological changes in coherent structures). Topological considerations strongly suggest that there nonetheless always exists a net throughflow region between inlet and outlet of the inline-mixing flow that is strictly separated from possible internal regions. The Lagrangian dynamics in this region admits representation by a 2D time-periodic Hamiltonian system. This establishes one fundamental kinematic structure for the present class of inline-mixing flows and implies universal behavior in that all states follow from the Hamiltonian breakdown of one common integrable state. A so-called period-doubling bifurcation is the only way to eliminate transport barriers originating from this state and thus is a necessary (yet not sufficient) condition for global chaos. Important in a practical context is that a common simplification in literature, i.e., cell-wise fully-developed Stokes flow (“2.5D approach”), retains these fundamental kinematic properties and deviates from the generic 3D inertial case only in a quantitative sense. This substantiates its suitability for (at least first exploratory) studies on (qualitative) mixing properties.« less

  16. High liquid yield process for retorting various organic materials including oil shale

    DOEpatents

    Coburn, Thomas T.

    1990-01-01

    This invention is a continuous retorting process for various high molecular weight organic materials, including oil shale, that yields an enhanced output of liquid product. The organic material, mineral matter, and an acidic catalyst, that appreciably adsorbs alkenes on surface sites at prescribed temperatures, are mixed and introduced into a pyrolyzer. A circulating stream of olefin enriched pyrolysis gas is continuously swept through the organic material and catalyst, whereupon, as the result of pyrolysis, the enhanced liquid product output is provided. Mixed spent organic material, mineral matter, and cool catalyst are continuously withdrawn from the pyrolyzer. Combustion of the spent organic material and mineral matter serves to reheat the catalyst. Olefin depleted pyrolysis gas, from the pyrolyzer, is enriched in olefins and recycled into the pyrolyzer. The reheated acidic catalyst is separated from the mineral matter and again mixed with fresh organic material, to maintain the continuously cyclic process.

  17. A high liquid yield process for retorting various organic materials including oil shale

    DOEpatents

    Coburn, T.T.

    1988-07-26

    This invention is a continuous retorting process for various high molecular weight organic materials, including oil shale, that yields an enhanced output of liquid product. The organic material, mineral matter, and an acidic catalyst, that appreciably adsorbs alkenes on surface sites at prescribed temperatures, are mixed and introduced into a pyrolyzer. A circulating stream of olefin enriched pyrolysis gas is continuously swept through the organic material and catalyst, whereupon, as the result of pyrolysis, the enhanced liquid product output is provided. Mixed spent organic material, mineral matter, and cool catalyst are continuously withdrawn from the pyrolyzer. Combustion of the spent organic material and mineral matter serves to reheat the catalyst. Olefin depleted pyrolysis gas, from the pyrolyzer, is enriched in olefins and recycled into the pyrolyzer. The reheated acidic catalyst is separated from the mineral matter and again mixed with fresh organic material, to maintain the continuously cyclic process. 2 figs.

  18. Contribution to the theory of stationary separation areas

    NASA Technical Reports Server (NTRS)

    Taganov, G. I.

    1985-01-01

    An attempt is made to determine the region of existence of possible steady flows with a closed separation area in a range of Reynolds numbers such that flow in the viscous mixing area can be described by the Prandtl's equations. The boundary conditions for the flow in the separation region are selected so as to simplify the flow pattern in this region, making it possible to use the methods of hydrodynamic analysis. A rule for determining stable steady flows with separation areas is formulated which is well suited for analyzing laminar flows and can be applied to turbulent flows in some areas.

  19. Monte Carlo PDF method for turbulent reacting flow in a jet-stirred reactor

    NASA Astrophysics Data System (ADS)

    Roekaerts, D.

    1992-01-01

    A stochastic algorithm for the solution of the modeled scalar probability density function (PDF) transport equation for single-phase turbulent reacting flow is described. Cylindrical symmetry is assumed. The PDF is represented by ensembles of N representative values of the thermochemical variables in each cell of a nonuniform finite-difference grid and operations on these elements representing convection, diffusion, mixing and reaction are derived. A simplified model and solution algorithm which neglects the influence of turbulent fluctuations on mean reaction rates is also described. Both algorithms are applied to a selectivity problem in a real reactor.

  20. Thermal effectiveness of multiple shell and tube pass TEMA E heat exchangers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pignotti, A.; Tamborenea, P.I.

    1988-02-01

    The thermal effectiveness of a TEMAE shell-and-tube heat exchanger, with one shell pass and an arbitrary number of tube passes, is determined under the usual simplifying assumptions of perfect transverse mixing of the shell fluid, no phase change, and temperature independence of the heat capacity rates and the heat transfer coefficient. A purely algebraic solution is obtained for the effectiveness as a functions of the heat capacity rate ratio and the number of heat transfer units. The case with M shell passes and N tube passes is easily expressed in terms of the single-shell-pass case.

  1. Using mixed reality, force feedback and tactile augmentation to improve the realism of medical simulation.

    PubMed

    Fisher, J Brian; Porter, Susan M

    2002-01-01

    This paper describes an application of a display approach which uses chromakey techniques to composite real and computer-generated images allowing a user to see his hands and medical instruments collocated with the display of virtual objects during a medical training simulation. Haptic feedback is provided through the use of a PHANTOM force feedback device in addition to tactile augmentation, which allows the user to touch virtual objects by introducing corresponding real objects in the workspace. A simplified catheter introducer insertion simulation was developed to demonstrate the capabilities of this approach.

  2. GAMBIT: A Parameterless Model-Based Evolutionary Algorithm for Mixed-Integer Problems.

    PubMed

    Sadowski, Krzysztof L; Thierens, Dirk; Bosman, Peter A N

    2018-01-01

    Learning and exploiting problem structure is one of the key challenges in optimization. This is especially important for black-box optimization (BBO) where prior structural knowledge of a problem is not available. Existing model-based Evolutionary Algorithms (EAs) are very efficient at learning structure in both the discrete, and in the continuous domain. In this article, discrete and continuous model-building mechanisms are integrated for the Mixed-Integer (MI) domain, comprising discrete and continuous variables. We revisit a recently introduced model-based evolutionary algorithm for the MI domain, the Genetic Algorithm for Model-Based mixed-Integer opTimization (GAMBIT). We extend GAMBIT with a parameterless scheme that allows for practical use of the algorithm without the need to explicitly specify any parameters. We furthermore contrast GAMBIT with other model-based alternatives. The ultimate goal of processing mixed dependences explicitly in GAMBIT is also addressed by introducing a new mechanism for the explicit exploitation of mixed dependences. We find that processing mixed dependences with this novel mechanism allows for more efficient optimization. We further contrast the parameterless GAMBIT with Mixed-Integer Evolution Strategies (MIES) and other state-of-the-art MI optimization algorithms from the General Algebraic Modeling System (GAMS) commercial algorithm suite on problems with and without constraints, and show that GAMBIT is capable of solving problems where variable dependences prevent many algorithms from successfully optimizing them.

  3. 40 CFR Appendix 3 to Subpart A of... - Procedure for Mixing Base Fluids With Sediments (EPA Method 1646)

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Procedure for Mixing Base Fluids With Sediments (EPA Method 1646) 3 Appendix 3 to Subpart A of Part 435 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS (CONTINUED) OIL AND GAS EXTRACTION POINT...

  4. Fast Mix Table Construction for Material Discretization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johnson, Seth R

    2013-01-01

    An effective hybrid Monte Carlo--deterministic implementation typically requires the approximation of a continuous geometry description with a discretized piecewise-constant material field. The inherent geometry discretization error can be reduced somewhat by using material mixing, where multiple materials inside a discrete mesh voxel are homogenized. Material mixing requires the construction of a ``mix table,'' which stores the volume fractions in every mixture so that multiple voxels with similar compositions can reference the same mixture. Mix table construction is a potentially expensive serial operation for large problems with many materials and voxels. We formulate an efficient algorithm to construct a sparse mix table inmore » $$O(\\text{number of voxels}\\times \\log \\text{number of mixtures})$$ time. The new algorithm is implemented in ADVANTG and used to discretize continuous geometries onto a structured Cartesian grid. When applied to an end-of-life MCNP model of the High Flux Isotope Reactor with 270 distinct materials, the new method improves the material mixing time by a factor of 100 compared to a naive mix table implementation.« less

  5. Performance of mixed formulations for the particle finite element method in soil mechanics problems

    NASA Astrophysics Data System (ADS)

    Monforte, Lluís; Carbonell, Josep Maria; Arroyo, Marcos; Gens, Antonio

    2017-07-01

    This paper presents a computational framework for the numerical analysis of fluid-saturated porous media at large strains. The proposal relies, on one hand, on the particle finite element method (PFEM), known for its capability to tackle large deformations and rapid changing boundaries, and, on the other hand, on constitutive descriptions well established in current geotechnical analyses (Darcy's law; Modified Cam Clay; Houlsby hyperelasticity). An important feature of this kind of problem is that incompressibility may arise either from undrained conditions or as a consequence of material behaviour; incompressibility may lead to volumetric locking of the low-order elements that are typically used in PFEM. In this work, two different three-field mixed formulations for the coupled hydromechanical problem are presented, in which either the effective pressure or the Jacobian are considered as nodal variables, in addition to the solid skeleton displacement and water pressure. Additionally, several mixed formulations are described for the simplified single-phase problem due to its formal similitude to the poromechanical case and its relevance in geotechnics, since it may approximate the saturated soil behaviour under undrained conditions. In order to use equal-order interpolants in displacements and scalar fields, stabilization techniques are used in the mass conservation equation of the biphasic medium and in the rest of scalar equations. Finally, all mixed formulations are assessed in some benchmark problems and their performances are compared. It is found that mixed formulations that have the Jacobian as a nodal variable perform better.

  6. Speed of evolution on graphs

    NASA Astrophysics Data System (ADS)

    Sui, Xiukai; Wu, Bin; Wang, Long

    2015-12-01

    The likelihood that a mutant fixates in the wild population, i.e., fixation probability, has been intensively studied in evolutionary game theory, where individuals' fitness is frequency dependent. However, it is of limited interest when it takes long to take over. Thus the speed of evolution becomes an important issue. In general, it is still unclear how fixation times are affected by the population structure, although the fixation times have already been addressed in the well-mixed populations. Here we theoretically address this issue by pair approximation and diffusion approximation on regular graphs. It is shown (i) that under neutral selection, both unconditional and conditional fixation time are shortened by increasing the number of neighbors; (ii) that under weak selection, for the simplified prisoner's dilemma game, if benefit-to-cost ratio exceeds the degree of the graph, then the unconditional fixation time of a single cooperator is slower than that in the neutral case; and (iii) that under weak selection, for the conditional fixation time, limited neighbor size dilutes the counterintuitive stochastic slowdown which was found in well-mixed populations. Interestingly, we find that all of our results can be interpreted as that in the well-mixed population with a transformed payoff matrix. This interpretation is also valid for both death-birth and birth-death processes on graphs. This interpretation bridges the fixation time in the structured population and that in the well-mixed population. Thus it opens the avenue to investigate the challenging fixation time in structured populations by the known results in well-mixed populations.

  7. The role of feedbacks in Antarctic sea ice change

    NASA Astrophysics Data System (ADS)

    Feltham, D. L.; Frew, R. C.; Holland, P.

    2017-12-01

    The changes in Antarctic sea ice over the last thirty years have a strong seasonal dependence, and the way these changes grow in spring and decay in autumn suggests that feedbacks are strongly involved. The changes may ultimately be caused by atmospheric warming, the winds, snowfall changes, etc., but we cannot understand these forcings without first untangling the feedbacks. A highly simplified coupled sea ice -mixed layer model has been developed to investigate the importance of feedbacks on the evolution of sea ice in two contrasting regions in the Southern Ocean; the Amundsen Sea where sea ice extent has been decreasing, and the Weddell Sea where it has been expanding. The change in mixed layer depth in response to changes in the atmosphere to ocean energy flux is implicit in a strong negative feedback on ice cover changes in the Amundsen Sea, with atmospheric cooling leading to a deeper mixed layer resulting in greater entrainment of warm Circumpolar Deep Water, causing increased basal melting of sea ice. This strong negative feedback produces counter intuitive responses to changes in forcings in the Amundsen Sea. This feedback is absent in the Weddell due to the complete destratification and strong water column cooling that occurs each winter in simulations. The impact of other feedbacks, including the albedo feedback, changes in insulation due to ice thickness and changes in the freezing temperature of the mixed layer, were found to be of secondary importance compared to changes in the mixed layer depth.

  8. Impact of Missing Physiologic Data on Performance of the Simplified Acute Physiology Score 3 Risk-Prediction Model.

    PubMed

    Engerström, Lars; Nolin, Thomas; Mårdh, Caroline; Sjöberg, Folke; Karlström, Göran; Fredrikson, Mats; Walther, Sten M

    2017-12-01

    The Simplified Acute Physiology 3 outcome prediction model has a narrow time window for recording physiologic measurements. Our objective was to examine the prevalence and impact of missing physiologic data on the Simplified Acute Physiology 3 model's performance. Retrospective analysis of prospectively collected data. Sixty-three ICUs in the Swedish Intensive Care Registry. Patients admitted during 2011-2014 (n = 107,310). None. Model performance was analyzed using the area under the receiver operating curve, scaled Brier's score, and standardized mortality rate. We used a recalibrated Simplified Acute Physiology 3 model and examined model performance in the original dataset and in a dataset of complete records where missing data were generated (simulated dataset). One or more data were missing in 40.9% of the admissions, more common in survivors and low-risk admissions than in nonsurvivors and high-risk admissions. Discrimination did not decrease with one to two missing variables, but accuracy was highest with no missing data. Calibration was best in the original dataset with a mix of full records and records with some missing values (area under the receiver operating curve was 0.85, scaled Brier 27%, and standardized mortality rate 0.99). With zero, one, and two data missing, the scaled Brier was 31%, 26%, and 21%; area under the receiver operating curve was 0.84, 0.87, and 0.89; and standardized mortality rate was 0.92, 1.05 and 1.10, respectively. Datasets where the missing data were simulated for oxygenation or oxygenation and hydrogen ion concentration together performed worse than datasets with these data originally missing. There is a coupling between missing physiologic data, admission type, low risk, and survival. Increased loss of physiologic data reduced model performance and will deflate mortality risk, resulting in falsely high standardized mortality rates.

  9. 26 CFR 1.401(a)(26)-7 - Testing methods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Testing methods. 1.401(a)(26)-7 Section 1.401(a... (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401(a)(26)-7 Testing methods... the rules in § 1.401(a)(26)-5. (b) Simplified testing method. A plan is treated as satisfying the...

  10. Transient Electromagnetic Wave Propagation in a Plasma Waveguide

    DTIC Science & Technology

    2011-10-24

    dielectric. The calculation of the propagation characteristics is based upon tangential continuity of the electric and magnetic field components...filament as a time-dependent resistance , we have determined the electron density, the kinetic parameters for electron attachment and recombination, and...wall conductivity simplifies the imposition of the boundary conditions. The tangential component of the electric field and the normal component of the

  11. Transmutation Scoping Studies for a Chloride Molten Salt Reactor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Heidet, Florent; Feng, Bo; Kim, Taek

    2016-01-01

    Over the past few years, there has been strong renewed interest from private industry, mostly from start-up enterprises, in molten salt reactor (MSR) technologies because of the unique properties of this class of reactors. These are reactors in which the fuel is homogeneously mixed with the coolant in the form of liquid salts and is circulated continuously into and out of the active core region with on-line fuel management, salt treatment, and salt processing. In response to such wide-spread interest, Argonne National Laboratory is expanding its well-established reactor modelling and simulation expertise and infrastructure to enable detailed analysis and designmore » of MSRs. The tools being developed are able to simulate the continuous fuel flow, the complex on-line fuel management and elemental removal processes (e.g., fission product removal) using depletion steps representative of a real MSR system. Leveraging these capabilities, a parametric study on the transmutation performance of a simplified actinide-burning MSR concept that uses a chloride-based salt was performed. This type of salt has attracted attention over the more commonly discussed fluoride-based salts since no tritium is produced as a result of irradiation and it is compatible with a fast neutron spectrum. The studies discussed in this paper examine the performance of a burner MSR design with a fixed core size and power density over a range of possible fuel salt molar ratios with NaCl-MgCl2 as the carrier salt. The intent is to quantify the impact on the required transuranics content of the make-up fuel, the actinide transmutation rates, and other performance characteristics for typical burner MSR designs.« less

  12. Orthogonal projection approach and continuous wavelet transform-feed forward neural networks for simultaneous spectrophotometric determination of some heavy metals in diet samples.

    PubMed

    Abbasi Tarighat, Maryam

    2016-02-01

    Simultaneous spectrophotometric determination of a mixture of overlapped complexes of Fe(3+), Mn(2+), Cu(2+), and Zn(2+) ions with 2-(3-hydroxy-1-phenyl-but-2-enylideneamino) pyridine-3-ol(HPEP) by orthogonal projection approach-feed forward neural network (OPA-FFNN) and continuous wavelet transform-feed forward neural network (CWT-FFNN) is discussed. Ionic complexes HPEP were formulated with varying reagent concentration, pH and time of color formation for completion of complexation reactions. It was found that, at 5.0 × 10(-4) mol L(-1) of HPEP, pH 9.5 and 10 min after mixing the complexation reactions were completed. The spectral data were analyzed using partial response plots, and identified non-linearity modeled using FFNN. Reducing the number of OPA-FFNN and CWT-FFNN inputs were simplified using dissimilarity pure spectra of OPA and selected wavelet coefficients. Once the pure dissimilarity plots ad optimal wavelet coefficients are selected, different ANN models were employed for the calculation of the final calibration models. The performance of these two approaches were tested with regard to root mean square errors of prediction (RMSE %) values, using synthetic solutions. Under the working conditions, the proposed methods were successfully applied to the simultaneous determination of metal ions in different vegetable and foodstuff samples. The results show that, OPA-FFNN and CWT-FFNN were effective in simultaneously determining Fe(3+), Mn(2+), Cu(2+), and Zn(2+) concentration. Also, concentrations of metal ions in the samples were determined by flame atomic absorption spectrometry (FAAS). The amounts of metal ions obtained by the proposed methods were in good agreement with those obtained by FAAS. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Generalized continuity equations from two-field Schrödinger Lagrangians

    NASA Astrophysics Data System (ADS)

    Spourdalakis, A. G. B.; Pappas, G.; Morfonios, C. Â. V.; Kalozoumis, P. A.; Diakonos, F. K.; Schmelcher, P.

    2016-11-01

    A variational scheme for the derivation of generalized, symmetry-induced continuity equations for Hermitian and non-Hermitian quantum mechanical systems is developed. We introduce a Lagrangian which involves two complex wave fields and whose global invariance under dilation and phase variations leads to a mixed continuity equation for the two fields. In combination with discrete spatial symmetries of the underlying Hamiltonian, the mixed continuity equation is shown to produce bilocal conservation laws for a single field. This leads to generalized conserved charges for vanishing boundary currents and to divergenceless bilocal currents for stationary states. The formalism reproduces the bilocal continuity equation obtained in the special case of P T -symmetric quantum mechanics and paraxial optics.

  14. Development and validation of a simplified titration method for monitoring volatile fatty acids in anaerobic digestion.

    PubMed

    Sun, Hao; Guo, Jianbin; Wu, Shubiao; Liu, Fang; Dong, Renjie

    2017-09-01

    The volatile fatty acids (VFAs) concentration has been considered as one of the most sensitive process performance indicators in anaerobic digestion (AD) process. However, the accurate determination of VFAs concentration in AD processes normally requires advanced equipment and complex pretreatment procedures. A simplified method with fewer sample pretreatment procedures and improved accuracy is greatly needed, particularly for on-site application. This report outlines improvements to the Nordmann method, one of the most popular titrations used for VFA monitoring. The influence of ion and solid interfering subsystems in titrated samples on results accuracy was discussed. The total solid content in titrated samples was the main factor affecting accuracy in VFA monitoring. Moreover, a high linear correlation was established between the total solids contents and VFA measurement differences between the traditional Nordmann equation and gas chromatography (GC). Accordingly, a simplified titration method was developed and validated using a semi-continuous experiment of chicken manure anaerobic digestion with various organic loading rates. The good fitting of the results obtained by this method in comparison with GC results strongly supported the potential application of this method to VFA monitoring. Copyright © 2017. Published by Elsevier Ltd.

  15. Continuous production of ethanol from hexoses and pentoses using immobilized mixed cultures of Escherichia coli strains

    PubMed Central

    Unrean, Pornkamol; Srienc, Friedrich

    2010-01-01

    We have developed highly efficient ethanologenic E. coli strains that selectively consume pentoses and/or hexoses. Mixed cultures of these strains can be used to selectively adjust the sugar utilization kinetics in ethanol fermentations. Based on the kinetics of sugar utilization, we have designed and implemented an immobilized cell system for the optimized continuous conversion of sugars into ethanol. The results confirm that immobilized mixed cultures support a simultaneous conversion of hexoses and pentoses into ethanol at high yield and at a faster rate than immobilized homogenous cells. Continuous ethanol production has been maintained for several weeks at high productivity with near complete sugar utilization. The control of sugar utilization using immobilized mixed cultures can be adapted to any composition of hexoses and pentoses by adjusting the strain distribution of immobilized cells. The approach, therefore, holds promise for ethanol fermentation from lignocellulosic hydrolysates where the feedstock varies in sugar composition. PMID:20699108

  16. Senstitivity analysis of horizontal heat and vapor transfer coefficients for a cloud-topped marine boundary layer during cold-air outbreaks. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Chang, Y. V.

    1986-01-01

    The effects of external parameters on the surface heat and vapor fluxes into the marine atmospheric boundary layer (MABL) during cold-air outbreaks are investigated using the numerical model of Stage and Businger (1981a). These fluxes are nondimensionalized using the horizontal heat (g1) and vapor (g2) transfer coefficient method first suggested by Chou and Atlas (1982) and further formulated by Stage (1983a). In order to simplify the problem, the boundary layer is assumed to be well mixed and horizontally homogeneous, and to have linear shoreline soundings of equivalent potential temperature and mixing ratio. Modifications of initial surface flux estimates, time step limitation, and termination conditions are made to the MABL model to obtain accurate computations. The dependence of g1 and g2 in the cloud topped boundary layer on the external parameters (wind speed, divergence, sea surface temperature, radiative sky temperature, cloud top radiation cooling, and initial shoreline soundings of temperature, and mixing ratio) is studied by a sensitivity analysis, which shows that the uncertainties of horizontal transfer coefficients caused by changes in the parameters are reasonably small.

  17. Broadband Shock Noise in Internally-Mixed Dual-Stream Jets

    NASA Technical Reports Server (NTRS)

    Bridges, James E.

    2009-01-01

    Broadband shock noise (BBSN) has been studied in some detail in single-flow jets and recently in dual-stream jets with separate flow exhaust systems. Shock noise is of great concern in these latter cases because of the noise created for the aircraft cabin by the underexpanded nozzle flow at cruise. Another case where shock noise is of concern is in the case of future supersonic aircraft that are expected to have bypass ratios small enough to justify internally mixed exhaust systems, and whose mission will push cycles to the point of imperfectly expanded flows. Dual-stream jets with internally mixed plume have some simplifying aspects relative to the separate flow jets, having a single shock structure given by the common nozzle pressure. This is used to separate the contribution of the turbulent shear layer to the broadband shock noise. Shock structure is held constant while the geometry and strength of the inner and merged shear layers are varying by changing splitter area ratio and core stream temperature. Flow and noise measurements are presented which document the efforts at separating the contribution of the inner shear layer to the broadband shock noise.

  18. Modeling of surface temperature effects on mixed material migration in NSTX-U

    NASA Astrophysics Data System (ADS)

    Nichols, J. H.; Jaworski, M. A.; Schmid, K.

    2016-10-01

    NSTX-U will initially operate with graphite walls, periodically coated with thin lithium films to improve plasma performance. However, the spatial and temporal evolution of these films during and after plasma exposure is poorly understood. The WallDYN global mixed-material surface evolution model has recently been applied to the NSTX-U geometry to simulate the evolution of poloidally inhomogenous mixed C/Li/O plasma-facing surfaces. The WallDYN model couples local erosion and deposition processes with plasma impurity transport in a non-iterative, self-consistent manner that maintains overall material balance. Temperature-dependent sputtering of lithium has been added to WallDYN, utilizing an adatom sputtering model developed from test stand experimental data. Additionally, a simplified temperature-dependent diffusion model has been added to WallDYN so as to capture the intercalation of lithium into a graphite bulk matrix. The sensitivity of global lithium migration patterns to changes in surface temperature magnitude and distribution will be examined. The effect of intra-discharge increases in surface temperature due to plasma heating, such as those observed during NSTX Liquid Lithium Divertor experiments, will also be examined. Work supported by US DOE contract DE-AC02-09CH11466.

  19. The Facilitators and Barriers to Nurses’ Participation in Continuing Education Programs: A Mixed Method Explanatory Sequential Study

    PubMed Central

    Shahhosseini, Zohreh; Hamzehgardeshi, Zeinab

    2015-01-01

    Background: Since several factors affect nurses’ participation in Continuing Education, and that nurses’ Continuing Education affects patients’ and community health status, it is essential to know facilitators and barriers of participation in Continuing Education programs and plan accordingly. This mixed approach study aimed to investigate the facilitators and barriers of nurses’ participation, to explore nurses’ perception of the most common facilitators and barriers. Methods: An explanatory sequential mixed methods design with follow up explanations variant were used, and it involved collecting quantitative data (361 nurses) first and then explaining the quantitative results with in-depth interviews during a qualitative study. Results: The results showed that the mean score of facilitators to nurses’ participation in Continuing Education was significantly higher than the mean score of barriers (61.99±10.85 versus 51.17±12.83; p<0.001, t=12.23). The highest mean score of facilitators of nurses’ participation in Continuing Education was related to “Update my knowledge”. By reviewing the handwritings in qualitative phase, two main levels of updating information and professional skills were extracted as the most common facilitators and lack of support as the most common barrier to nurses’ participation in continuing education program. Conclusion: According to important role Continuing Education on professional skills, nurse managers should facilitate the nurse’ participation in the Continues Education. PMID:25948439

  20. The facilitators and barriers to nurses' participation in continuing education programs: a mixed method explanatory sequential study.

    PubMed

    Shahhosseini, Zohreh; Hamzehgardeshi, Zeinab

    2014-11-30

    Since several factors affect nurses' participation in Continuing Education, and that nurses' Continuing Education affects patients' and community health status, it is essential to know facilitators and barriers of participation in Continuing Education programs and plan accordingly. This mixed approach study aimed to investigate the facilitators and barriers of nurses' participation, to explore nurses' perception of the most common facilitators and barriers. An explanatory sequential mixed methods design with follow up explanations variant were used, and it involved collecting quantitative data (361 nurses) first and then explaining the quantitative results with in-depth interviews during a qualitative study. The results showed that the mean score of facilitators to nurses' participation in Continuing Education was significantly higher than the mean score of barriers (61.99 ± 10.85 versus 51.17 ± 12.83; p<0.001, t=12.23). The highest mean score of facilitators of nurses' participation in Continuing Education was related to "Update my knowledge". By reviewing the handwritings in qualitative phase, two main levels of updating information and professional skills were extracted as the most common facilitators and lack of support as the most common barrier to nurses' participation in continuing education program. According to important role Continuing Education on professional skills, nurse managers should facilitate the nurse' participation in the Continues Education.

  1. Lagrangian particles with mixing. I. Simulating scalar transport

    NASA Astrophysics Data System (ADS)

    Klimenko, A. Y.

    2009-06-01

    The physical similarity and mathematical equivalence of continuous diffusion and particle random walk forms one of the cornerstones of modern physics and the theory of stochastic processes. The randomly walking particles do not need to posses any properties other than location in physical space. However, particles used in many models dealing with simulating turbulent transport and turbulent combustion do posses a set of scalar properties and mixing between particle properties is performed to reflect the dissipative nature of the diffusion processes. We show that the continuous scalar transport and diffusion can be accurately specified by means of localized mixing between randomly walking Lagrangian particles with scalar properties and assess errors associated with this scheme. Particles with scalar properties and localized mixing represent an alternative formulation for the process, which is selected to represent the continuous diffusion. Simulating diffusion by Lagrangian particles with mixing involves three main competing requirements: minimizing stochastic uncertainty, minimizing bias introduced by numerical diffusion, and preserving independence of particles. These requirements are analyzed for two limited cases of mixing between two particles and mixing between a large number of particles. The problem of possible dependences between particles is most complicated. This problem is analyzed using a coupled chain of equations that has similarities with Bogolubov-Born-Green-Kirkwood-Yvon chain in statistical physics. Dependences between particles can be significant in close proximity of the particles resulting in a reduced rate of mixing. This work develops further ideas introduced in the previously published letter [Phys. Fluids 19, 031702 (2007)]. Paper I of this work is followed by Paper II [Phys. Fluids 19, 065102 (2009)] where modeling of turbulent reacting flows by Lagrangian particles with localized mixing is specifically considered.

  2. Teleportation of a Kind of Three-Mode Entangled States of Continuous Variables

    NASA Astrophysics Data System (ADS)

    Fan, Hong-Yi; Liang, Xian-Ting

    2005-11-01

    A quantum teleportation scheme to teleport a kind of tripartite entangled states of continuous variables by using a quantum channel composed of three bipartite entangled states is proposed. The joint Bell measurement is feasible because the bipartite entangled states are complete and the squeezed state has a natural representation in the entangled state basis. The calculation is greatly simplified by using the Schmidt decomposition of the entangled states. The project supported by the President Funds of the Chinese Academy of Sciences and National Natural Science Foundation of China under Grant No. 10475056

  3. Modeling of Radiative Heat Transfer in an Electric Arc Furnace

    NASA Astrophysics Data System (ADS)

    Opitz, Florian; Treffinger, Peter; Wöllenstein, Jürgen

    2017-12-01

    Radiation is an important means of heat transfer inside an electric arc furnace (EAF). To gain insight into the complex processes of heat transfer inside the EAF vessel, not only radiation from the surfaces but also emission and absorption of the gas phase and the dust cloud need to be considered. Furthermore, the radiative heat exchange depends on the geometrical configuration which is continuously changing throughout the process. The present paper introduces a system model of the EAF which takes into account the radiative heat transfer between the surfaces and the participating medium. This is attained by the development of a simplified geometrical model, the use of a weighted-sum-of-gray-gases model, and a simplified consideration of dust radiation. The simulation results were compared with the data of real EAF plants available in literature.

  4. 40 CFR 439.40 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) PHARMACEUTICAL MANUFACTURING POINT SOURCE CATEGORY Mixing/Compounding and Formulation § 439.40... pharmaceutical products by mixing, compounding and formulating operations. [63 FR 50435, Sept. 21, 1998] ...

  5. Solving the small-scale structure puzzles with dissipative dark matter

    NASA Astrophysics Data System (ADS)

    Foot, Robert; Vagnozzi, Sunny

    2016-07-01

    Small-scale structure is studied in the context of dissipative dark matter, arising for instance in models with a hidden unbroken Abelian sector, so that dark matter couples to a massless dark photon. The dark sector interacts with ordinary matter via gravity and photon-dark photon kinetic mixing. Mirror dark matter is a theoretically constrained special case where all parameters are fixed except for the kinetic mixing strength, epsilon. In these models, the dark matter halo around spiral and irregular galaxies takes the form of a dissipative plasma which evolves in response to various heating and cooling processes. It has been argued previously that such dynamics can account for the inferred cored density profiles of galaxies and other related structural features. Here we focus on the apparent deficit of nearby small galaxies (``missing satellite problem"), which these dissipative models have the potential to address through small-scale power suppression by acoustic and diffusion damping. Using a variant of the extended Press-Schechter formalism, we evaluate the halo mass function for the special case of mirror dark matter. Considering a simplified model where Mbaryons propto Mhalo, we relate the halo mass function to more directly observable quantities, and find that for epsilon ≈ 2 × 10-10 such a simplified description is compatible with the measured galaxy luminosity and velocity functions. On scales Mhalo lesssim 108 Msolar, diffusion damping exponentially suppresses the halo mass function, suggesting a nonprimordial origin for dwarf spheroidal satellite galaxies, which we speculate were formed via a top-down fragmentation process as the result of nonlinear dissipative collapse of larger density perturbations. This could explain the planar orientation of satellite galaxies around Andromeda and the Milky Way.

  6. 29 CFR 1926.1086 - Mixed-gas diving.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 8 2011-07-01 2011-07-01 false Mixed-gas diving. 1926.1086 Section 1926.1086 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Mixed-gas diving. Note: The requirements applicable to construction work under this section are...

  7. 29 CFR 1926.1086 - Mixed-gas diving.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 8 2013-07-01 2013-07-01 false Mixed-gas diving. 1926.1086 Section 1926.1086 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Mixed-gas diving. Note: The requirements applicable to construction work under this section are...

  8. 29 CFR 1926.1086 - Mixed-gas diving.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 8 2014-07-01 2014-07-01 false Mixed-gas diving. 1926.1086 Section 1926.1086 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Mixed-gas diving. Note: The requirements applicable to construction work under this section are...

  9. 29 CFR 1926.1086 - Mixed-gas diving.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 8 2012-07-01 2012-07-01 false Mixed-gas diving. 1926.1086 Section 1926.1086 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... Mixed-gas diving. Note: The requirements applicable to construction work under this section are...

  10. Fast mix table construction for material discretization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Johnson, S. R.

    2013-07-01

    An effective hybrid Monte Carlo-deterministic implementation typically requires the approximation of a continuous geometry description with a discretized piecewise-constant material field. The inherent geometry discretization error can be reduced somewhat by using material mixing, where multiple materials inside a discrete mesh voxel are homogenized. Material mixing requires the construction of a 'mix table,' which stores the volume fractions in every mixture so that multiple voxels with similar compositions can reference the same mixture. Mix table construction is a potentially expensive serial operation for large problems with many materials and voxels. We formulate an efficient algorithm to construct a sparse mixmore » table in O(number of voxels x log number of mixtures) time. The new algorithm is implemented in ADVANTG and used to discretize continuous geometries onto a structured Cartesian grid. When applied to an end-of-life MCNP model of the High Flux Isotope Reactor with 270 distinct materials, the new method improves the material mixing time by a factor of 100 compared to a naive mix table implementation. (authors)« less

  11. Mixing behavior of the rhombic micromixers over a wide Reynolds number range using Taguchi method and 3D numerical simulations.

    PubMed

    Chung, C K; Shih, T R; Chen, T C; Wu, B H

    2008-10-01

    A planar micromixer with rhombic microchannels and a converging-diverging element has been systematically investigated by the Taguchi method, CFD-ACE simulations and experiments. To reduce the footprint and extend the operation range of Reynolds number, Taguchi method was used to numerically study the performance of the micromixer in a L(9) orthogonal array. Mixing efficiency is prominently influenced by geometrical parameters and Reynolds number (Re). The four factors in a L(9) orthogonal array are number of rhombi, turning angle, width of the rhombic channel and width of the throat. The degree of sensitivity by Taguchi method can be ranked as: Number of rhombi > Width of the rhombic channel > Width of the throat > Turning angle of the rhombic channel. Increasing the number of rhombi, reducing the width of the rhombic channel and throat and lowering the turning angle resulted in better fluid mixing efficiency. The optimal design of the micromixer in simulations indicates over 90% mixing efficiency at both Re > or = 80 and Re < or = 0.1. Experimental results in the optimal simulations are consistent with the simulated one. This planar rhombic micromixer has simplified the complex fabrication process of the multi-layer or three-dimensional micromixers and improved the performance of a previous rhombic micromixer at a reduced footprint and lower Re.

  12. Acoustic⁻Seismic Mixed Feature Extraction Based on Wavelet Transform for Vehicle Classification in Wireless Sensor Networks.

    PubMed

    Zhang, Heng; Pan, Zhongming; Zhang, Wenna

    2018-06-07

    An acoustic⁻seismic mixed feature extraction method based on the wavelet coefficient energy ratio (WCER) of the target signal is proposed in this study for classifying vehicle targets in wireless sensor networks. The signal was decomposed into a set of wavelet coefficients using the à trous algorithm, which is a concise method used to implement the wavelet transform of a discrete signal sequence. After the wavelet coefficients of the target acoustic and seismic signals were obtained, the energy ratio of each layer coefficient was calculated as the feature vector of the target signals. Subsequently, the acoustic and seismic features were merged into an acoustic⁻seismic mixed feature to improve the target classification accuracy after the acoustic and seismic WCER features of the target signal were simplified using the hierarchical clustering method. We selected the support vector machine method for classification and utilized the data acquired from a real-world experiment to validate the proposed method. The calculated results show that the WCER feature extraction method can effectively extract the target features from target signals. Feature simplification can reduce the time consumption of feature extraction and classification, with no effect on the target classification accuracy. The use of acoustic⁻seismic mixed features effectively improved target classification accuracy by approximately 12% compared with either acoustic signal or seismic signal alone.

  13. Effect of supplementing orchardgrass herbage with a total mixed ration or flaxseed fermentation profile and bacterial protein synthesis in continuous culture

    USDA-ARS?s Scientific Manuscript database

    A 4-unit dual-flow continuous culture fermentor system was used to evaluate the effects of herbage, a total mixed ration (TMR) and flaxseed on nutrient digestibility and microbial N synthesis. Treatments were randomly assigned to fermentors in a 4 x 4 Latin square design. Each fermentor was fed a to...

  14. Flowmeter determines mix ratio for viscous adhesives

    NASA Technical Reports Server (NTRS)

    Lemons, C. R.

    1967-01-01

    Flowmeter determines mix ratio for continuous flow mixing machine used to produce an adhesive from a high viscosity resin and aliphatic amine hardener pumped through separate lines to a rotary blender. The flowmeter uses strain gages in the two flow paths and monitors their outputs with appropriate instrumentation.

  15. A simplified ingestion procedure for esophageal capsule endoscopy: initial evaluation in healthy volunteers.

    PubMed

    Gralnek, I M; Rabinovitz, R; Afik, D; Eliakim, R

    2006-09-01

    Initial studies on esophageal capsule endoscopy (PillCam ESO) reported excellent sensitivity and specificity, but these were followed by mixed results in several subsequent studies, probably due to deviations from the recommended ingestion protocol and the inconvenience of capsule ingestion in the supine position. The aim of this study was therefore to test a simplified ingestion procedure (SIP) for PillCam ESO. Using a cross-over study design, the SIP was prospectively compared with the original ingestion procedure for PillCam ESO in 24 healthy volunteers (15 men, nine women; mean age 44, range 27 - 70) and evaluated for: bubbles/saliva interference at the Z-line, Z-line circumferential visualization (quadrants), and convenience and ease of the ingestion procedure. All Rapid 4 videos were reviewed in a randomized manner and read by an experienced PillCam ESO reader blinded to the ingestion procedure used. It was found that the SIP significantly improved visualization in comparison with the original ingestion procedure, with less interference due to bubbles/saliva observed at the gastroesophageal junction ( P = 0.002) and improved visualization of the Z-line ( P = 0.025). Although the esophageal transit time was significantly faster with the SIP (3 : 45 min vs. 0 : 38 min; P = 0.0001), there were no differences in the number of Z-line frames/images captured. This new, simplified ingestion procedure for PillCam ESO provides significantly improved visualization of the Z-line in healthy volunteers. The overall test characteristics of PillCam ESO using SIP should be tested in patients with esophageal disease.

  16. Form and Function of Linguistic Elements

    DTIC Science & Technology

    2009-02-20

    Chomsky (1957) and continued into the frameworks from around Chomsky’s Aspects (1965). The main thrust was to move from grammars centered on covering...Miminalist Program Grammars Work by Chomsky , starting around 1995 ( Chomsky 1995) represents a move toward radically simplified systems. A...particular theories can be formulated as choices within such a general scheme or metatheory. 14 We take Richard Montague’s Universal Grammar

  17. Application of computer graphics in the design of custom orthopedic implants.

    PubMed

    Bechtold, J E

    1986-10-01

    Implementation of newly developed computer modelling techniques and computer graphics displays and software have greatly aided the orthopedic design engineer and physician in creating a custom implant with good anatomic conformity in a short turnaround time. Further advances in computerized design and manufacturing will continue to simplify the development of custom prostheses and enlarge their niche in the joint replacement market.

  18. Three Proposals to Simplify the Federal Student Aid System: A Critical Reply from Financial Aid Administrators at Historically Black Colleges and Universities

    ERIC Educational Resources Information Center

    Boyd, Marcia D.

    2014-01-01

    Financial aid programs are supposed to improve access and affordability in higher education (Gillen, 2009). The effectiveness of these programs is increasingly being questioned as college attainment figures stagnate and the financial burden on students and families continues to climb year after year. The purpose of this study was to examine the…

  19. The Graded Alluvial River: Variable Flow and the Dominant Discharge

    NASA Astrophysics Data System (ADS)

    Blom, A.; Arkesteijn, L.; Viparelli, E.

    2016-12-01

    We derive analytical formulations for the graded or equilibrium longitudinal profile of a mixed-sediment alluvial river under variable flow. The formulations are applicable to reaches upstream from the backwater zone. The model is based on the conservation equations for the mass of two distinct sediment modes, sand and gravel, at the bed surface to account for the effects of grain size selective transport and abrasion of gravel particles. The effects of a variable flow rate are included by (a) treating the flow as a continuously changing yet steady water discharge (i.e. here termed an alternating steady discharge) and (b) assuming the time scale of changes in channel slope and bed surface texture to be much larger than the one of changes in flow rate. The equations are simplified realizing that at equilibrium the river profile finds itself in a dynamic steady state with oscillations around constant mean values of channel slope and bed surface texture. A generalized sediment transport relation representing the stochastic nature of sediment transport allows for explicit or analytical solutions to the streamwise decrease of both the channel slope and the bed surface mean grain size under variable flow for reaches unaffected by backwater effects. This modelling approach also provides a definition of a channel-forming or dominant water discharge, i.e., that steady water discharge that is equivalent in its effect on the equilibrium channel slope to the full hydrograph.

  20. Compaction of Ductile and Fragile Grains

    NASA Astrophysics Data System (ADS)

    Creissac, S.; Pouliquen, O.; Dalloz-Dubrujeaud, B.

    2009-06-01

    The compaction of powders into tablets is widely used in several industries (cosmetics, food, pharmaceutics…). In all these industries, the composition of the initial powder is complex, and the behaviour under compaction is not well known, also the mechanical behaviour of the tablets. The aim of this paper is to understand the behaviour (pressure vs density) of a simplified media made of fragile and ductile powders, varying the relative ratio of each powder. Some compaction experiments were carried out with glass beads (fragile) and Polyethylen Glycol powder (ductile). We observe two typical behaviours, depending on the relative volumic fraction of each component. A transition is pointed out, observing the evolution of the slope of the curve pressure/density. This transition is explained by geometrical considerations during compaction. A model is proposed, based on the assumption that the studied media can be compare to a diphasic material with a continuous phase (the ductile powder) and a discrete phase (the fragile powder). The result of this model is compare to the experimental results of compaction, and give a good prediction of the behaviour of the different mixing, knowing the behaviour of the ductile and the fragile phase separately. These results were also interpreted in terms of Heckel parameter which characterizes the ability of the powder to deform plastically under compaction. Some mechanical tests were also performed to compare the mechanical resitance of the obtained tablets.

  1. Transverse mixing of conservative and reactive tracers in porous media: Quantification through the concepts of flux-related and critical dilution indices

    NASA Astrophysics Data System (ADS)

    Chiogna, Gabriele; Cirpka, Olaf A.; Grathwohl, Peter; Rolle, Massimo

    2011-02-01

    The correct quantification of mixing is of utmost importance for modeling reactive transport in porous media and for assessing the fate and transport of contaminants in the subsurface. An appropriate measure of mixing in heterogeneous porous formations should correctly capture the effects on mixing intensity of various processes at different scales, such as local dispersion and the mixing enhancement due to heterogeneities. In this work, we use the concept of flux-related dilution index as a measure of transverse mixing. This quantity expresses the dilution of the mass flux of a conservative tracer solution over the total discharge of the system, and is particularly suited to address problems where a compound is continuously injected into the domain. We focus our attention on two-dimensional systems under steady state flow conditions and investigate both conservative and reactive transport in homogeneous and heterogeneous porous media at different scales. For mixing-controlled reactive systems, we introduce and illustrate the concept of critical dilution index, which represents the amount of mixing required for complete degradation of a continuously emitted plume undergoing decay upon mixing with ambient water. We perform two-dimensional numerical experiments at bench and field scales in homogeneous and heterogeneous conductivity fields. These numerical simulations show that the flux-related dilution index quantifies mixing and that the concept of critical dilution index is a useful measure to relate the mixing of conservative tracers to mixing-controlled degradation of reactive compounds.

  2. EuroForMix: An open source software based on a continuous model to evaluate STR DNA profiles from a mixture of contributors with artefacts.

    PubMed

    Bleka, Øyvind; Storvik, Geir; Gill, Peter

    2016-03-01

    We have released a software named EuroForMix to analyze STR DNA profiles in a user-friendly graphical user interface. The software implements a model to explain the allelic peak height on a continuous scale in order to carry out weight-of-evidence calculations for profiles which could be from a mixture of contributors. Through a properly parameterized model we are able to do inference on mixture proportions, the peak height properties, stutter proportion and degradation. In addition, EuroForMix includes models for allele drop-out, allele drop-in and sub-population structure. EuroForMix supports two inference approaches for likelihood ratio calculations. The first approach uses maximum likelihood estimation of the unknown parameters. The second approach is Bayesian based which requires prior distributions to be specified for the parameters involved. The user may specify any number of known and unknown contributors in the model, however we find that there is a practical computing time limit which restricts the model to a maximum of four unknown contributors. EuroForMix is the first freely open source, continuous model (accommodating peak height, stutter, drop-in, drop-out, population substructure and degradation), to be reported in the literature. It therefore serves an important purpose to act as an unrestricted platform to compare different solutions that are available. The implementation of the continuous model used in the software showed close to identical results to the R-package DNAmixtures, which requires a HUGIN Expert license to be used. An additional feature in EuroForMix is the ability for the user to adapt the Bayesian inference framework by incorporating their own prior information. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  3. 19 CFR 151.25 - Mixing classes of sugar.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Mixing classes of sugar. 151.25 Section 151.25... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Sugars, Sirups, and Molasses § 151.25 Mixing classes of sugar. No regulations relative to the weighing, taring, sampling, classifying...

  4. 19 CFR 151.25 - Mixing classes of sugar.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Mixing classes of sugar. 151.25 Section 151.25... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Sugars, Sirups, and Molasses § 151.25 Mixing classes of sugar. No regulations relative to the weighing, taring, sampling, classifying...

  5. 19 CFR 151.25 - Mixing classes of sugar.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Mixing classes of sugar. 151.25 Section 151.25... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Sugars, Sirups, and Molasses § 151.25 Mixing classes of sugar. No regulations relative to the weighing, taring, sampling, classifying...

  6. 19 CFR 151.25 - Mixing classes of sugar.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Mixing classes of sugar. 151.25 Section 151.25... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Sugars, Sirups, and Molasses § 151.25 Mixing classes of sugar. No regulations relative to the weighing, taring, sampling, classifying...

  7. 19 CFR 151.25 - Mixing classes of sugar.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Mixing classes of sugar. 151.25 Section 151.25... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Sugars, Sirups, and Molasses § 151.25 Mixing classes of sugar. No regulations relative to the weighing, taring, sampling, classifying...

  8. A novel formulation for unsteady counterflow flames using a thermal-conductivity-weighted coordinate

    NASA Astrophysics Data System (ADS)

    Weiss, Adam D.; Vera, Marcos; Liñán, Amable; Sánchez, Antonio L.; Williams, Forman A.

    2018-01-01

    A general formulation is given for the description of reacting mixing layers in stagnation-type flows subject to both time-varying strain and pressure. The salient feature of the formulation is the introduction of a thermal-conductivity-weighted transverse coordinate that leads to a compact transport operator that facilitates numerical integration and theoretical analysis. For steady counterflow mixing layers, the associated transverse mass flux is shown to be effectively linear in terms of the new coordinate, so that the conservation equations for energy and chemical species uncouple from the mass and momentum conservation equations, thereby greatly simplifying the solution. Comparisons are shown with computations of diffusion flames with infinitely fast reaction using both the classic Howarth-Dorodnitzyn density-weighted coordinate and the new thermal-conductivity-weighted coordinate, illustrating the advantages of the latter. Also, as an illustrative application of the formulation to the computation of unsteady counterflows, the flame response to harmonically varying strain is examined in the linear limit.

  9. Can Condensing Organic Aerosols Lead to Less Cloud Particles?

    NASA Astrophysics Data System (ADS)

    Gao, C. Y.; Tsigaridis, K.; Bauer, S.

    2017-12-01

    We examined the impact of condensing organic aerosols on activated cloud number concentration in a new aerosol microphysics box model, MATRIX-VBS. The model includes the volatility-basis set (VBS) framework in an aerosol microphysical scheme MATRIX (Multiconfiguration Aerosol TRacker of mIXing state) that resolves aerosol mass and number concentrations and aerosol mixing state. Preliminary results show that by including the condensation of organic aerosols, the new model (MATRIX-VBS) has less activated particles compared to the original model (MATRIX), which treats organic aerosols as non-volatile. Parameters such as aerosol chemical composition, mass and number concentrations, and particle sizes which affect activated cloud number concentration are thoroughly evaluated via a suite of Monte-Carlo simulations. The Monte-Carlo simulations also provide information on which climate-relevant parameters play a critical role in the aerosol evolution in the atmosphere. This study also helps simplifying the newly developed box model which will soon be implemented in the global model GISS ModelE as a module.

  10. Refracted arrival waves in a zone of silence from a finite thickness mixing layer.

    PubMed

    Suzuki, Takao; Lele, Sanjiva K

    2002-02-01

    Refracted arrival waves which propagate in the zone of silence of a finite thickness mixing layer are analyzed using geometrical acoustics in two dimensions. Here, two simplifying assumptions are made: (i) the mean flow field is transversely sheared, and (ii) the mean velocity and temperature profiles approach the free-stream conditions exponentially. Under these assumptions, ray trajectories are analytically solved, and a formula for acoustic pressure amplitude in the far field is derived in the high-frequency limit. This formula is compared with the existing theory based on a vortex sheet corresponding to the low-frequency limit. The analysis covers the dependence on the Mach number as well as on the temperature ratio. The results show that both limits have some qualitative similarities, but the amplitude in the zone of silence at high frequencies is proportional to omega(-1/2), while that at low frequencies is proportional to omega(-3/2), omega being the angular frequency of the source.

  11. Hunting Down Massless Dark Photons in Kaon Physics.

    PubMed

    Fabbrichesi, M; Gabrielli, E; Mele, B

    2017-07-21

    If dark photons are massless, they couple to standard-model particles only via higher dimensional operators, while direct (renormalizable) interactions induced by kinetic mixing, which motivates most of the current experimental searches, are absent. We consider the effect of possible flavor-changing magnetic-dipole couplings of massless dark photons in kaon physics. In particular, we study the branching ratio for the process K^{+}→π^{+}π^{0}γ[over ¯] with a simplified-model approach, assuming the chiral quark model to evaluate the hadronic matrix element. Possible effects in the K^{0}-K[over ¯]^{0} mixing are taken into account. We find that branching ratios up to O(10^{-7}) are allowed-depending on the dark-sector masses and couplings. Such large branching ratios for K^{+}→π^{+}π^{0}γ[over ¯] could be of interest for experiments dedicated to rare K^{+} decays like NA62 at CERN, where γ[over ¯] can be detected as a massless invisible system.

  12. Sintering Process and Mechanical Property of MWCNTs/HDPE Bulk Composite.

    PubMed

    Ming-Wen, Wang; Tze-Chi, Hsu; Jie-Ren, Zheng

    2009-08-01

    Studies have proved that increasing polymer matrices by carbon nanotubes to form structural reinforcement and electrical conductivity have significantly improved mechanical and electrical properties at very low carbon nanotubes loading. In other words, increasing polymer matrices by carbon nanotubes to form structural reinforcement can reduce friction coefficient and enhance anti-wear property. However, producing traditional MWCNTs in polymeric materix is an extremely complicated process. Using melt-mixing process or in situ polymerization leads to better dispersion effect on composite materials. In this study, therefore, to simplify MWCNTs /HDPE composite process and increase dispersion, powder was used directly to replace pellet to mix and sinter with MWCNTs. The composite bulks with 0, 0.5, 1, 2 and 4% nanotube content by weight was analyzed under SEM to observe nanotubes dispersion. At this rate, a MWCNTs/HDPE composite bulk with uniformly dispersed MWCNTs was achieved, and through the wear bench (Pin-on-Disk), the wear experiment has accomplished. Accordingly, the result suggests the sintered MWCNTs/HDPE composites amplify the hardness and wear-resist property.

  13. Alignment-free, all-spliced fiber laser source for CARS microscopy based on four-wave-mixing.

    PubMed

    Baumgartl, Martin; Gottschall, Thomas; Abreu-Afonso, Javier; Díez, Antonio; Meyer, Tobias; Dietzek, Benjamin; Rothhardt, Manfred; Popp, Jürgen; Limpert, Jens; Tünnermann, Andreas

    2012-09-10

    An environmentally-stable low-repetition rate fiber oscillator is developed to produce narrow-bandwidth pulses with several tens of picoseconds duration. Based on this oscillator an alignment-free all-fiber laser for multi-photon microscopy is realized using in-fiber frequency conversion based on four-wave-mixing. Both pump and Stokes pulses for coherent anti-Stokes Raman scattering (CARS) microscopy are readily available from one fiber end, intrinsically overlapped in space and time, which drastically simplifies the experimental handling for the user. The complete laser setup is mounted on a home-built laser scanning microscope with small footprint. High-quality multimodal microscope images of biological tissue are presented probing the CH-stretching resonance of lipids at an anti-Stokes Raman-shift of 2845 cm(-1) and second-harmonic generation of collagen. Due to its simplicity, compactness, maintenance-free operation, and ease-of-use the presented low-cost laser is an ideal source for bio-medical applications outside laser laboratories and in particular inside clinics.

  14. Combining cationic and anionic mixed-mode sorbents in a single cartridge to extract basic and acidic pharmaceuticals simultaneously from environmental waters.

    PubMed

    Salas, Daniela; Borrull, Francesc; Fontanals, Núria; Marcé, Rosa Maria

    2018-01-01

    The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.

  15. Modeling and parameters identification of 2-keto-L-gulonic acid fed-batch fermentation.

    PubMed

    Wang, Tao; Sun, Jibin; Yuan, Jingqi

    2015-04-01

    This article presents a modeling approach for industrial 2-keto-L-gulonic acid (2-KGA) fed-batch fermentation by the mixed culture of Ketogulonicigenium vulgare (K. vulgare) and Bacillus megaterium (B. megaterium). A macrokinetic model of K. vulgare is constructed based on the simplified metabolic pathways. The reaction rates obtained from the macrokinetic model are then coupled into a bioreactor model such that the relationship between substrate feeding rates and the main state variables, e.g., the concentrations of the biomass, substrate and product, is constructed. A differential evolution algorithm using the Lozi map as the random number generator is utilized to perform the model parameters identification, with the industrial data of 2-KGA fed-batch fermentation. Validation results demonstrate that the model simulations of substrate and product concentrations are well in coincidence with the measurements. Furthermore, the model simulations of biomass concentrations reflect principally the growth kinetics of the two microbes in the mixed culture.

  16. TEMPEST code modifications and testing for erosion-resisting sludge simulations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Onishi, Y.; Trent, D.S.

    The TEMPEST computer code has been used to address many waste retrieval operational and safety questions regarding waste mobilization, mixing, and gas retention. Because the amount of sludge retrieved from the tank is directly related to the sludge yield strength and the shear stress acting upon it, it is important to incorporate the sludge yield strength into simulations of erosion-resisting tank waste retrieval operations. This report describes current efforts to modify the TEMPEST code to simulate pump jet mixing of erosion-resisting tank wastes and the models used to test for erosion of waste sludge with yield strength. Test results formore » solid deposition and diluent/slurry jet injection into sludge layers in simplified tank conditions show that the modified TEMPEST code has a basic ability to simulate both the mobility and immobility of the sludges with yield strength. Further testing, modification, calibration, and verification of the sludge mobilization/immobilization model are planned using erosion data as they apply to waste tank sludges.« less

  17. 26 CFR 1.1092(b)-3T - Mixed straddles; straddle-by-straddle identification under section 1092(b)(2)(A)(i)(I) (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 11 2014-04-01 2014-04-01 false Mixed straddles; straddle-by-straddle... (CONTINUED) Wash Sales of Stock Or Securities § 1.1092(b)-3T Mixed straddles; straddle-by-straddle... are part of a mixed straddle for which the taxpayer has made an election under paragraph (d) of this...

  18. 26 CFR 1.1092(b)-3T - Mixed straddles; straddle-by-straddle identification under section 1092(b)(2)(A)(i)(I) (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 11 2013-04-01 2013-04-01 false Mixed straddles; straddle-by-straddle... (CONTINUED) Wash Sales of Stock Or Securities § 1.1092(b)-3T Mixed straddles; straddle-by-straddle... are part of a mixed straddle for which the taxpayer has made an election under paragraph (d) of this...

  19. 26 CFR 1.1092(b)-3T - Mixed straddles; straddle-by-straddle identification under section 1092(b)(2)(A)(i)(I) (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Mixed straddles; straddle-by-straddle... (CONTINUED) Wash Sales of Stock Or Securities § 1.1092(b)-3T Mixed straddles; straddle-by-straddle... are part of a mixed straddle for which the taxpayer has made an election under paragraph (d) of this...

  20. 26 CFR 1.1092(b)-3T - Mixed straddles; straddle-by-straddle identification under section 1092(b)(2)(A)(i)(I) (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Mixed straddles; straddle-by-straddle... (CONTINUED) Wash Sales of Stock Or Securities § 1.1092(b)-3T Mixed straddles; straddle-by-straddle... are part of a mixed straddle for which the taxpayer has made an election under paragraph (d) of this...

  1. The FODA-TDMA satellite access scheme - Presentation, study of the system, and results

    NASA Astrophysics Data System (ADS)

    Celandroni, Nedo; Ferro, Erina

    1991-12-01

    A description is given of FODA-TDMA, a satellite access scheme designed for mixed traffic. The study of the system is presented and the choice of some parameters is justified. A simplified analytic solution is found, describing the steady-state behavior of the system. Some results of the simulation tests for an already existing hardware environment are also presented for the channel speeds of 2 and 8 Mb/s, considering both the stationary and the transient cases. The results of the experimentation at 2 Mb/s on the satellite Eutelsat-F2 are also presented and compared with the results of the simulation.

  2. Estimation of cardiac reserve by peak power: validation and initial application of a simplified index

    NASA Technical Reports Server (NTRS)

    Armstrong, G. P.; Carlier, S. G.; Fukamachi, K.; Thomas, J. D.; Marwick, T. H.

    1999-01-01

    OBJECTIVES: To validate a simplified estimate of peak power (SPP) against true (invasively measured) peak instantaneous power (TPP), to assess the feasibility of measuring SPP during exercise and to correlate this with functional capacity. DESIGN: Development of a simplified method of measurement and observational study. SETTING: Tertiary referral centre for cardiothoracic disease. SUBJECTS: For validation of SPP with TPP, seven normal dogs and four dogs with dilated cardiomyopathy were studied. To assess feasibility and clinical significance in humans, 40 subjects were studied (26 patients; 14 normal controls). METHODS: In the animal validation study, TPP was derived from ascending aortic pressure and flow probe, and from Doppler measurements of flow. SPP, calculated using the different flow measures, was compared with peak instantaneous power under different loading conditions. For the assessment in humans, SPP was measured at rest and during maximum exercise. Peak aortic flow was measured with transthoracic continuous wave Doppler, and systolic and diastolic blood pressures were derived from brachial sphygmomanometry. The difference between exercise and rest simplified peak power (Delta SPP) was compared with maximum oxygen uptake (VO(2)max), measured from expired gas analysis. RESULTS: SPP estimates using peak flow measures correlated well with true peak instantaneous power (r = 0.89 to 0.97), despite marked changes in systemic pressure and flow induced by manipulation of loading conditions. In the human study, VO(2)max correlated with Delta SPP (r = 0.78) better than Delta ejection fraction (r = 0.18) and Delta rate-pressure product (r = 0.59). CONCLUSIONS: The simple product of mean arterial pressure and peak aortic flow (simplified peak power, SPP) correlates with peak instantaneous power over a range of loading conditions in dogs. In humans, it can be estimated during exercise echocardiography, and correlates with maximum oxygen uptake better than ejection fraction or rate-pressure product.

  3. Similarity theory of the buoyantly interactive planetary boundary layer with entrainment

    NASA Technical Reports Server (NTRS)

    Hoffert, M. I.; Sud, Y. C.

    1976-01-01

    A similarity model is developed for the vertical profiles of turbulent flow variables in an entraining turbulent boundary layer of arbitrary buoyant stability. In the general formulation the vertical profiles, internal rotation of the velocity vector, discontinuities or jumps at a capping inversion and bulk aerodynamic coefficients of the boundary layer are given by solutions to a system of ordinary differential equations in the similarity variable. To close the system, a formulation for buoyantly interactive eddy diffusivity in the boundary layer is introduced which recovers Monin-Obukhov similarity near the surface and incorporates a hypothesis accounting for the observed variation of mixing length throughout the boundary layer. The model is tested in simplified versions which depend only on roughness, surface buoyancy, and Coriolis effects by comparison with planetary-boundary-layer wind- and temperature-profile observations, measurements of flat-plate boundary layers in a thermally stratified wind tunnel and observations of profiles of terms in the turbulent kinetic-energy budget of convective planetary boundary layers. On balance, the simplified model reproduced the trend of these various observations and experiments reasonably well, suggesting that the full similarity formulation be pursued further.

  4. Simplified DFT methods for consistent structures and energies of large systems

    NASA Astrophysics Data System (ADS)

    Caldeweyher, Eike; Gerit Brandenburg, Jan

    2018-05-01

    Kohn–Sham density functional theory (DFT) is routinely used for the fast electronic structure computation of large systems and will most likely continue to be the method of choice for the generation of reliable geometries in the foreseeable future. Here, we present a hierarchy of simplified DFT methods designed for consistent structures and non-covalent interactions of large systems with particular focus on molecular crystals. The covered methods are a minimal basis set Hartree–Fock (HF-3c), a small basis set screened exchange hybrid functional (HSE-3c), and a generalized gradient approximated functional evaluated in a medium-sized basis set (B97-3c), all augmented with semi-classical correction potentials. We give an overview on the methods design, a comprehensive evaluation on established benchmark sets for geometries and lattice energies of molecular crystals, and highlight some realistic applications on large organic crystals with several hundreds of atoms in the primitive unit cell.

  5. Evaluation of Several Approximate Methods for Calculating the Symmetrical Bending-Moment Response of Flexible Airplanes to Isotropic Atmospheric Turbulence

    NASA Technical Reports Server (NTRS)

    Bennett, Floyd V.; Yntema, Robert T.

    1959-01-01

    Several approximate procedures for calculating the bending-moment response of flexible airplanes to continuous isotropic turbulence are presented and evaluated. The modal methods (the mode-displacement and force-summation methods) and a matrix method (segmented-wing method) are considered. These approximate procedures are applied to a simplified airplane for which an exact solution to the equation of motion can be obtained. The simplified airplane consists of a uniform beam with a concentrated fuselage mass at the center. Airplane motions are limited to vertical rigid-body translation and symmetrical wing bending deflections. Output power spectra of wing bending moments based on the exact transfer-function solutions are used as a basis for the evaluation of the approximate methods. It is shown that the force-summation and the matrix methods give satisfactory accuracy and that the mode-displacement method gives unsatisfactory accuracy.

  6. Large-scale production of lipoplexes with long shelf-life.

    PubMed

    Clement, Jule; Kiefer, Karin; Kimpfler, Andrea; Garidel, Patrick; Peschka-Süss, Regine

    2005-01-01

    The instability of lipoplex formulations is a major obstacle to overcome before their commercial application in gene therapy. In this study, a continuous mixing technique for the large-scale preparation of lipoplexes followed by lyophilisation for increased stability and shelf-life has been developed. Lipoplexes were analysed for transfection efficiency and cytotoxicity in human aorta smooth muscle cells (HASMC) and a rat smooth muscle cell line (A-10 SMC). Homogeneity of lipid/DNA-products was investigated by photon correlation spectroscopy (PCS) and cryotransmission electron microscopy (cryo-TEM). Studies have been undertaken with DAC-30, a composition of 3beta-[N-(N,N'-dimethylaminoethane)-carbamoyl]-cholesterol (DAC-Chol) and dioleylphosphatidylethanolamine (DOPE) and a green fluorescent protein (GFP) expressing marker plasmid. A continuous mixing technique was compared to the small-scale preparation of lipoplexes by pipetting. Individual steps of the continuous mixing process were evaluated in order to optimise the manufacturing technique: lipid/plasmid ratio, composition of transfection medium, pre-treatment of the lipid, size of the mixing device, mixing procedure and the influence of the lyophilisation process. It could be shown that the method developed for production of lipoplexes on a large scale under sterile conditions led to lipoplexes with good transfection efficiencies combined with low cytotoxicity, improved characteristics and long shelf-life.

  7. Space Shuttle propulsion parameter estimation using optimal estimation techniques

    NASA Technical Reports Server (NTRS)

    1983-01-01

    This fourth monthly progress report again contains corrections and additions to the previously submitted reports. The additions include a simplified SRB model that is directly incorporated into the estimation algorithm and provides the required partial derivatives. The resulting partial derivatives are analytical rather than numerical as would be the case using the SOBER routines. The filter and smoother routine developments have continued. These routines are being checked out.

  8. Nuclear cardiac

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Slutsky, R.; Ashburn, W.L.

    1982-01-01

    The relationship between nuclear medicine and cardiology has continued to produce a surfeit of interesting, illuminating, and important reports involving the analysis of cardiac function, perfusion, and metabolism. To simplify the presentation, this review is broken down into three major subheadings: analysis of myocardial perfusion; imaging of the recent myocardial infarction; and the evaluation of myocardial function. There appears to be an increasingly important relationship between cardiology, particularly cardiac physiology, and nuclear imaging techniques. (KRM)

  9. Research study on stabilization and control: Modern sampled data control theory

    NASA Technical Reports Server (NTRS)

    Kuo, B. C.; Singh, G.; Yackel, R. A.

    1973-01-01

    A numerical analysis of spacecraft stability parameters was conducted. The analysis is based on a digital approximation by point by point state comparison. The technique used is that of approximating a continuous data system by a sampled data model by comparison of the states of the two systems. Application of the method to the digital redesign of the simplified one axis dynamics of the Skylab is presented.

  10. Automatic flexible endoscope reprocessors.

    PubMed

    Muscarella, L F

    2000-04-01

    Reprocessing medical instruments is a complex and controversial discipline. If all instruments were constructed of materials not damaged by heat, pressure, and moisture, instrument reprocessing would be greatly simplified. As the number of novel and complex instruments entering the market continues to increase, periodic review of the health care facility's instrument reprocessing protocols to ensure their safety and effectiveness is important. This article reviews the advantages and the limitations of automatic flexible endoscope reprocessors.

  11. Fluid mechanics of continuous flow electrophoresis

    NASA Technical Reports Server (NTRS)

    Saville, D. A.; Ostrach, S.

    1978-01-01

    The following aspects of continuous flow electrophoresis were studied: (1) flow and temperature fields; (2) hydrodynamic stability; (3) separation efficiency, and (4) characteristics of wide gap chambers (the SPAR apparatus). Simplified mathematical models were developed so as to furnish a basis for understanding the phenomena and comparison of different chambers and operating conditions. Studies of the hydrodynamic stability disclosed that a wide gap chamber may be particularly sensitive to axial temperature variations which could be due to uneven heating or cooling. The mathematical model of the separation process includes effects due to the axial velocity, electro-osmotic cross flow and electrophoretic migration, all including the effects of temperature dependent properties.

  12. Accurate Simulation of Parametrically Excited Micromirrors via Direct Computation of the Electrostatic Stiffness

    PubMed Central

    Frangi, Attilio; Guerrieri, Andrea; Boni, Nicoló

    2017-01-01

    Electrostatically actuated torsional micromirrors are key elements in Micro-Opto-Electro- Mechanical-Systems. When forced by means of in-plane comb-fingers, the dynamics of the main torsional response is known to be strongly non-linear and governed by parametric resonance. Here, in order to also trace unstable branches of the mirror response, we implement a simplified continuation method with arc-length control and propose an innovative technique based on Finite Elements and the concepts of material derivative in order to compute the electrostatic stiffness; i.e., the derivative of the torque with respect to the torsional angle, as required by the continuation approach. PMID:28383483

  13. Accurate Simulation of Parametrically Excited Micromirrors via Direct Computation of the Electrostatic Stiffness.

    PubMed

    Frangi, Attilio; Guerrieri, Andrea; Boni, Nicoló

    2017-04-06

    Electrostatically actuated torsional micromirrors are key elements in Micro-Opto-Electro- Mechanical-Systems. When forced by means of in-plane comb-fingers, the dynamics of the main torsional response is known to be strongly non-linear and governed by parametric resonance. Here, in order to also trace unstable branches of the mirror response, we implement a simplified continuation method with arc-length control and propose an innovative technique based on Finite Elements and the concepts of material derivative in order to compute the electrostatic stiffness; i.e., the derivative of the torque with respect to the torsional angle, as required by the continuation approach.

  14. Mixed Beam Murine Harderian Gland Tumorigenesis: Predicted Dose-Effect Relationships if neither Synergism nor Antagonism Occurs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siranart, Nopphon; Blakely, Eleanor A.; Cheng, Alden

    Complex mixed radiation fields exist in interplanetary space, and not much is known about their latent effects on space travelers. In silico synergy analysis default predictions are useful when planning relevant mixed-ion-beam experiments and interpreting their results. These predictions are based on individual dose-effect relationships (IDER) for each component of the mixed-ion beam, assuming no synergy or antagonism. For example, a default hypothesis of simple effect additivity has often been used throughout the study of biology. However, for more than a century pharmacologists interested in mixtures of therapeutic drugs have analyzed conceptual, mathematical and practical questions similar to those thatmore » arise when analyzing mixed radiation fields, and have shown that simple effect additivity often gives unreasonable predictions when the IDER are curvilinear. Various alternatives to simple effect additivity proposed in radiobiology, pharmacometrics, toxicology and other fields are also known to have important limitations. In this work, we analyze upcoming murine Harderian gland (HG) tumor prevalence mixed-beam experiments, using customized open-source software and published IDER from past single-ion experiments. The upcoming experiments will use acute irradiation and the mixed beam will include components of high atomic number and energy (HZE). We introduce a new alternative to simple effect additivity, "incremental effect additivity", which is more suitable for the HG analysis and perhaps for other end points. We use incremental effect additivity to calculate default predictions for mixture dose-effect relationships, including 95% confidence intervals. We have drawn three main conclusions from this work. 1. It is important to supplement mixed-beam experiments with single-ion experiments, with matching end point(s), shielding and dose timing. 2. For HG tumorigenesis due to a mixed beam, simple effect additivity and incremental effect additivity sometimes give default predictions that are numerically close. However, if nontargeted effects are important and the mixed beam includes a number of different HZE components, simple effect additivity becomes unusable and another method is needed such as incremental effect additivity. 3. Eventually, synergy analysis default predictions of the effects of mixed radiation fields will be replaced by more mechanistic, biophysically-based predictions. However, optimizing synergy analyses is an important first step. If mixed-beam experiments indicate little synergy or antagonism, plans by NASA for further experiments and possible missions beyond low earth orbit will be substantially simplified.« less

  15. Oscillations in the reduction of permanganate by hydrogen peroxide or by ninhydrin in a batch reactor and mixed-mode oscillations in a continuous-flow stirred tank reactor

    NASA Astrophysics Data System (ADS)

    Tóthová, Mária; Nagy, Arpád; Treindl, Ľudovít.

    1999-01-01

    The periodical reduction of permanganate by hydrogen peroxide or by ninhydrin with transient oscillations in a closed system has been observed and discussed in relation to the first two permanganate oscillators described earlier. The mixed-mode oscillations of the permanganate-H 2O 2 oscillating system in a continuous-flow stirred tank reactor have been described.

  16. Multiwatt-level continuous-wave midwave infrared generation using difference frequency mixing in periodically poled MgO-doped lithium niobate.

    PubMed

    Guha, Shekhar; Barnes, Jacob O; Gonzalez, Leonel P

    2014-09-01

    Over 3.5 W of continuous-wave power at 3.4 μm was obtained by single-pass difference frequency mixing of 1.064 and 1.55 μm fiber lasers in a 5 cm long periodically poled lithium niobate crystal. Good agreement was obtained between the observed temperature dependence of the generated power and the prediction from focused Gaussian beam theory.

  17. New deconvolution method for microscopic images based on the continuous Gaussian radial basis function interpolation model.

    PubMed

    Chen, Zhaoxue; Chen, Hao

    2014-01-01

    A deconvolution method based on the Gaussian radial basis function (GRBF) interpolation is proposed. Both the original image and Gaussian point spread function are expressed as the same continuous GRBF model, thus image degradation is simplified as convolution of two continuous Gaussian functions, and image deconvolution is converted to calculate the weighted coefficients of two-dimensional control points. Compared with Wiener filter and Lucy-Richardson algorithm, the GRBF method has an obvious advantage in the quality of restored images. In order to overcome such a defect of long-time computing, the method of graphic processing unit multithreading or increasing space interval of control points is adopted, respectively, to speed up the implementation of GRBF method. The experiments show that based on the continuous GRBF model, the image deconvolution can be efficiently implemented by the method, which also has a considerable reference value for the study of three-dimensional microscopic image deconvolution.

  18. Universal Quantum Computing with Arbitrary Continuous-Variable Encoding.

    PubMed

    Lau, Hoi-Kwan; Plenio, Martin B

    2016-09-02

    Implementing a qubit quantum computer in continuous-variable systems conventionally requires the engineering of specific interactions according to the encoding basis states. In this work, we present a unified formalism to conduct universal quantum computation with a fixed set of operations but arbitrary encoding. By storing a qubit in the parity of two or four qumodes, all computing processes can be implemented by basis state preparations, continuous-variable exponential-swap operations, and swap tests. Our formalism inherits the advantages that the quantum information is decoupled from collective noise, and logical qubits with different encodings can be brought to interact without decoding. We also propose a possible implementation of the required operations by using interactions that are available in a variety of continuous-variable systems. Our work separates the "hardware" problem of engineering quantum-computing-universal interactions, from the "software" problem of designing encodings for specific purposes. The development of quantum computer architecture could hence be simplified.

  19. Universal Quantum Computing with Arbitrary Continuous-Variable Encoding

    NASA Astrophysics Data System (ADS)

    Lau, Hoi-Kwan; Plenio, Martin B.

    2016-09-01

    Implementing a qubit quantum computer in continuous-variable systems conventionally requires the engineering of specific interactions according to the encoding basis states. In this work, we present a unified formalism to conduct universal quantum computation with a fixed set of operations but arbitrary encoding. By storing a qubit in the parity of two or four qumodes, all computing processes can be implemented by basis state preparations, continuous-variable exponential-swap operations, and swap tests. Our formalism inherits the advantages that the quantum information is decoupled from collective noise, and logical qubits with different encodings can be brought to interact without decoding. We also propose a possible implementation of the required operations by using interactions that are available in a variety of continuous-variable systems. Our work separates the "hardware" problem of engineering quantum-computing-universal interactions, from the "software" problem of designing encodings for specific purposes. The development of quantum computer architecture could hence be simplified.

  20. Optimization and cost estimation of novel wheat biorefining for continuous production of fermentation feedstock.

    PubMed

    Arifeen, Najmul; Wang, Ruohang; Kookos, Ioannis; Webb, Colin; Koutinas, Apostolis A

    2007-01-01

    A wheat-based continuous process for the production of a nutrient-complete feedstock for bioethanol production by yeast fermentation has been cost-optimized. This process could substitute for the current wheat dry milling process employed in industry for bioethanol production. Each major wheat component (bran, gluten, starch) is extracted and processed for different end-uses. The separate stages, liquefaction and saccharification, used currently in industry for starch hydrolysis have been integrated into a simplified continuous process by exploiting the complex enzymatic consortium produced by on-site fungal bioconversions. A process producing 120 m3 h-1 nutrient-complete feedstock for bioethanol production containing 250 g L-1 glucose and 0.85 g L-1 free amino nitrogen would result in a production cost of $0.126/kg glucose.

  1. Recalibrating disease parameters for increasing realism in modeling epidemics in closed settings.

    PubMed

    Bioglio, Livio; Génois, Mathieu; Vestergaard, Christian L; Poletto, Chiara; Barrat, Alain; Colizza, Vittoria

    2016-11-14

    The homogeneous mixing assumption is widely adopted in epidemic modelling for its parsimony and represents the building block of more complex approaches, including very detailed agent-based models. The latter assume homogeneous mixing within schools, workplaces and households, mostly for the lack of detailed information on human contact behaviour within these settings. The recent data availability on high-resolution face-to-face interactions makes it now possible to assess the goodness of this simplified scheme in reproducing relevant aspects of the infection dynamics. We consider empirical contact networks gathered in different contexts, as well as synthetic data obtained through realistic models of contacts in structured populations. We perform stochastic spreading simulations on these contact networks and in populations of the same size under a homogeneous mixing hypothesis. We adjust the epidemiological parameters of the latter in order to fit the prevalence curve of the contact epidemic model. We quantify the agreement by comparing epidemic peak times, peak values, and epidemic sizes. Good approximations of the peak times and peak values are obtained with the homogeneous mixing approach, with a median relative difference smaller than 20 % in all cases investigated. Accuracy in reproducing the peak time depends on the setting under study, while for the peak value it is independent of the setting. Recalibration is found to be linear in the epidemic parameters used in the contact data simulations, showing changes across empirical settings but robustness across groups and population sizes. An adequate rescaling of the epidemiological parameters can yield a good agreement between the epidemic curves obtained with a real contact network and a homogeneous mixing approach in a population of the same size. The use of such recalibrated homogeneous mixing approximations would enhance the accuracy and realism of agent-based simulations and limit the intrinsic biases of the homogeneous mixing.

  2. Wastewater microalgal production, nutrient removal and physiological adaptation in response to changes in mixing frequency.

    PubMed

    Sutherland, Donna L; Turnbull, Matthew H; Broady, Paul A; Craggs, Rupert J

    2014-09-15

    Laminar flows are a common problem in high rate algal ponds (HRAP) due to their long channels and gentle mixing by a single paddlewheel. Sustained laminar flows may modify the amount of light microalgal cells are exposed to, increase the boundary layer between the cell and the environment and increase settling out of cells onto the pond bottom. To date, there has been little focus on the effects of the time between mixing events (frequency of mixing) on the performance of microalgae in wastewater treatment HRAPs. This paper investigates the performance of three morphologically distinct microalgae in wastewater treatment high rate algal mesocosms operated at four different mixing frequencies (continuous, mixed every 45 min, mixed every 90 min and no mixing). Microalgal performance was measured in terms of biomass concentration, nutrient removal efficiency, light utilisation and photosynthetic performance. Microalgal biomass increased significantly with increasing mixing frequency for the two colonial species but did not differ for the single celled species. All three species were more efficient at NH4-N uptake as the frequency of mixing increased. Increased frequency of mixing supported larger colonies with improved harvest-ability by gravity but at the expense of efficient light absorption and maximum rate of photosynthesis. However, maximum quantum yield was highest in the continuously mixed cultures due to higher efficiency of photosynthesis under light limited conditions. Based on these results, higher microalgal productivity, improved wastewater treatment and better gravity based harvest-ability can be achieved with the inclusion of more mixing points and reduced laminar flows in full-scale HRAP. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. The robust model predictive control based on mixed H2/H∞ approach with separated performance formulations and its ISpS analysis

    NASA Astrophysics Data System (ADS)

    Li, Dewei; Li, Jiwei; Xi, Yugeng; Gao, Furong

    2017-12-01

    In practical applications, systems are always influenced by parameter uncertainties and external disturbance. Both the H2 performance and the H∞ performance are important for the real applications. For a constrained system, the previous designs of mixed H2/H∞ robust model predictive control (RMPC) optimise one performance with the other performance requirement as a constraint. But the two performances cannot be optimised at the same time. In this paper, an improved design of mixed H2/H∞ RMPC for polytopic uncertain systems with external disturbances is proposed to optimise them simultaneously. In the proposed design, the original uncertain system is decomposed into two subsystems by the additive character of linear systems. Two different Lyapunov functions are used to separately formulate the two performance indices for the two subsystems. Then, the proposed RMPC is designed to optimise both the two performances by the weighting method with the satisfaction of the H∞ performance requirement. Meanwhile, to make the design more practical, a simplified design is also developed. The recursive feasible conditions of the proposed RMPC are discussed and the closed-loop input state practical stable is proven. The numerical examples reflect the enlarged feasible region and the improved performance of the proposed design.

  4. Counting on the mental number line to make a move: sensorimotor ('pen') control and numerical processing.

    PubMed

    Sheridan, Rebecca; van Rooijen, Maaike; Giles, Oscar; Mushtaq, Faisal; Steenbergen, Bert; Mon-Williams, Mark; Waterman, Amanda

    2017-10-01

    Mathematics is often conducted with a writing implement. But is there a relationship between numerical processing and sensorimotor 'pen' control? We asked participants to move a stylus so it crossed an unmarked line at a location specified by a symbolic number (1-9), where number colour indicated whether the line ran left-right ('normal') or vice versa ('reversed'). The task could be simplified through the use of a 'mental number line' (MNL). Many modern societies use number lines in mathematical education and the brain's representation of number appears to follow a culturally determined spatial organisation (so better task performance is associated with this culturally normal orientation-the MNL effect). Participants (counter-balanced) completed two consistent blocks of trials, 'normal' and 'reversed', followed by a mixed block where line direction varied randomly. Experiment 1 established that the MNL effect was robust, and showed that the cognitive load associated with reversing the MNL not only affected response selection but also the actual movement execution (indexed by duration) within the mixed trials. Experiment 2 showed that an individual's motor abilities predicted performance in the difficult (mixed) condition but not the easier blocks. These results suggest that numerical processing is not isolated from motor capabilities-a finding with applied consequences.

  5. A mixed finite-element method for solving the poroelastic Biot equations with electrokinetic coupling

    NASA Astrophysics Data System (ADS)

    Pain, C. C.; Saunders, J. H.; Worthington, M. H.; Singer, J. M.; Stuart-Bruges, W.; Mason, G.; Goddard, A.

    2005-02-01

    In this paper, a numerical method for solving the Biot poroelastic equations is developed. These equations comprise acoustic (typically water) and elastic (porous medium frame) equations, which are coupled mainly through fluid/solid drag terms. This wave solution is coupled to a simplified form of Maxwell's equations, which is solved for the streaming potential resulting from electrokinesis. The ultimate aim is to use the generated electrical signals to provide porosity, permeability and other information about the formation surrounding a borehole. The electrical signals are generated through electrokinesis by seismic waves causing movement of the fluid through pores or fractures of a porous medium. The focus of this paper is the numerical solution of the Biot equations in displacement form, which is achieved using a mixed finite-element formulation with a different finite-element representation for displacements and stresses. The mixed formulation is used in order to reduce spurious displacement modes and fluid shear waves in the numerical solutions. These equations are solved in the time domain using an implicit unconditionally stable time-stepping method using iterative solution methods amenable to solving large systems of equations. The resulting model is embodied in the MODELLING OF ACOUSTICS, POROELASTICS AND ELECTROKINETICS (MAPEK) computer model for electroseismic analysis.

  6. Brownian dynamics simulation of amphiphilic block copolymers with different tail lengths, comparison with theory and comicelles.

    PubMed

    Hafezi, Mohammad-Javad; Sharif, Farhad

    2015-11-01

    Study on the effect of amphiphilic copolymers structure on their self assembly is an interesting subject, with important applications in the area of drug delivery and biological system treatments. Brownian dynamics simulations were performed to study self-assembly of the linear amphiphilic block copolymers with the same hydrophilic head, but hydrophobic tails of different lengths. Critical micelle concentration (CMC), gyration radius distribution, micelle size distribution, density profiles of micelles, shape anisotropy, and dynamics of micellization were investigated as a function of tail length. Simulation results were compared with predictions from theory and simulation for mixed systems of block copolymers with long and short hydrophobic tail, reported in our previous work. Interestingly, the equilibrium structural and dynamic parameters of pure and mixed block copolymers were similarly dependant on the intrinsic/apparent hydrophobic block length. Log (CMC) was, however; proportional to the tail length and had a different behavior compared to the mixed system. The power law scaling relation of equilibrium structural parameters for amphiphilic block copolymers predicts the same dependence for similar hydrophobic tail lengths, but the power law prediction of CMC is different, which is due to its simplifying assumptions as discussed here. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Laboratory accelerated stripping simulator for hot mix asphalt.

    DOT National Transportation Integrated Search

    2005-01-18

    Moisture susceptibility of hot mix asphalt (HMA) pavements continues to be a major pavement distress. Past research : has primarily focused on HMA stripping prevention through material component evaluation/testing and addition of : preventative addit...

  8. Can We Mix Jocks and Jills?

    ERIC Educational Resources Information Center

    Freedman, Ira

    1979-01-01

    Since Title IX was enacted in 1975, schools have been liberalizing physical education in both elementary and secondary grades. Despite some initial wariness and low participation rates, mixed physical education classes continue to grow and improve. (EB)

  9. Sensitivity of the ocean overturning circulation to wind and mixing: theoretical scalings and global ocean models

    NASA Astrophysics Data System (ADS)

    Nikurashin, Maxim; Gunn, Andrew

    2017-04-01

    The meridional overturning circulation (MOC) is a planetary-scale oceanic flow which is of direct importance to the climate system: it transports heat meridionally and regulates the exchange of CO2 with the atmosphere. The MOC is forced by wind and heat and freshwater fluxes at the surface and turbulent mixing in the ocean interior. A number of conceptual theories for the sensitivity of the MOC to changes in forcing have recently been developed and tested with idealized numerical models. However, the skill of the simple conceptual theories to describe the MOC simulated with higher complexity global models remains largely unknown. In this study, we present a systematic comparison of theoretical and modelled sensitivity of the MOC and associated deep ocean stratification to vertical mixing and southern hemisphere westerlies. The results show that theories that simplify the ocean into a single-basin, zonally-symmetric box are generally in a good agreement with a realistic, global ocean circulation model. Some disagreement occurs in the abyssal ocean, where complex bottom topography is not taken into account by simple theories. Distinct regimes, where the MOC has a different sensitivity to wind or mixing, as predicted by simple theories, are also clearly shown by the global ocean model. The sensitivity of the Indo-Pacific, Atlantic, and global basins is analysed separately to validate the conceptual understanding of the upper and lower overturning cells in the theory.

  10. 29 CFR 780.711 - Exemption of mixed business applies only to country elevators.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Exemption of mixed business applies only to country elevators. 780.711 Section 780.711 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... Elevator § 780.711 Exemption of mixed business applies only to country elevators. The language of section...

  11. 29 CFR 780.711 - Exemption of mixed business applies only to country elevators.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Exemption of mixed business applies only to country elevators. 780.711 Section 780.711 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... Elevator § 780.711 Exemption of mixed business applies only to country elevators. The language of section...

  12. 29 CFR 780.711 - Exemption of mixed business applies only to country elevators.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Exemption of mixed business applies only to country elevators. 780.711 Section 780.711 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION... Elevator § 780.711 Exemption of mixed business applies only to country elevators. The language of section...

  13. CGBayesNets: Conditional Gaussian Bayesian Network Learning and Inference with Mixed Discrete and Continuous Data

    PubMed Central

    Weiss, Scott T.

    2014-01-01

    Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous variables. Existing free BN software packages either discretize continuous variables, which can lead to information loss, or do not include inference routines, which makes prediction with the BN impossible. We present CGBayesNets, a BN package focused around prediction of a clinical phenotype from mixed discrete and continuous variables, which fills these gaps. CGBayesNets implements Bayesian likelihood and inference algorithms for the conditional Gaussian Bayesian network (CGBNs) formalism, one appropriate for predicting an outcome of interest from, e.g., multimodal genomic data. We provide four different network learning algorithms, each making a different tradeoff between computational cost and network likelihood. CGBayesNets provides a full suite of functions for model exploration and verification, including cross validation, bootstrapping, and AUC manipulation. We highlight several results obtained previously with CGBayesNets, including predictive models of wood properties from tree genomics, leukemia subtype classification from mixed genomic data, and robust prediction of intensive care unit mortality outcomes from metabolomic profiles. We also provide detailed example analysis on public metabolomic and gene expression datasets. CGBayesNets is implemented in MATLAB and available as MATLAB source code, under an Open Source license and anonymous download at http://www.cgbayesnets.com. PMID:24922310

  14. CGBayesNets: conditional Gaussian Bayesian network learning and inference with mixed discrete and continuous data.

    PubMed

    McGeachie, Michael J; Chang, Hsun-Hsien; Weiss, Scott T

    2014-06-01

    Bayesian Networks (BN) have been a popular predictive modeling formalism in bioinformatics, but their application in modern genomics has been slowed by an inability to cleanly handle domains with mixed discrete and continuous variables. Existing free BN software packages either discretize continuous variables, which can lead to information loss, or do not include inference routines, which makes prediction with the BN impossible. We present CGBayesNets, a BN package focused around prediction of a clinical phenotype from mixed discrete and continuous variables, which fills these gaps. CGBayesNets implements Bayesian likelihood and inference algorithms for the conditional Gaussian Bayesian network (CGBNs) formalism, one appropriate for predicting an outcome of interest from, e.g., multimodal genomic data. We provide four different network learning algorithms, each making a different tradeoff between computational cost and network likelihood. CGBayesNets provides a full suite of functions for model exploration and verification, including cross validation, bootstrapping, and AUC manipulation. We highlight several results obtained previously with CGBayesNets, including predictive models of wood properties from tree genomics, leukemia subtype classification from mixed genomic data, and robust prediction of intensive care unit mortality outcomes from metabolomic profiles. We also provide detailed example analysis on public metabolomic and gene expression datasets. CGBayesNets is implemented in MATLAB and available as MATLAB source code, under an Open Source license and anonymous download at http://www.cgbayesnets.com.

  15. Bell-Curve Genetic Algorithm for Mixed Continuous and Discrete Optimization Problems

    NASA Technical Reports Server (NTRS)

    Kincaid, Rex K.; Griffith, Michelle; Sykes, Ruth; Sobieszczanski-Sobieski, Jaroslaw

    2002-01-01

    In this manuscript we have examined an extension of BCB that encompasses a mix of continuous and quasi-discrete, as well as truly-discrete applications. FVe began by testing two refinements to the discrete version of BCB. The testing of midpoint versus fitness (Tables 1 and 2) proved inconclusive. The testing of discrete normal tails versus standard mutation showed was conclusive and demonstrated that the discrete normal tails are better. Next, we implemented these refinements in a combined continuous and discrete BCB and compared the performance of two discrete distance on the hub problem. Here we found when "order does matter" it pays to take it into account.

  16. Geochemistry of the Madison and Minnelusa aquifers in the Black Hills area, South Dakota

    USGS Publications Warehouse

    Naus, Cheryl A.; Driscoll, Daniel G.; Carter, Janet M.

    2001-01-01

    The Madison and Minnelusa aquifers are two of the most important aquifers in the Black Hills area because of utilization for water supplies and important influences on surface-water resources resulting from large springs and streamflow- loss zones. Examination of geochemical information provides a better understanding of the complex flow systems within these aquifers and interactions between the aquifers. Major-ion chemistry in both aquifers is dominated by calcium and bicarbonate near outcrop areas, with basinward evolution towards various other water types. The most notable differences in major-ion chemistry between the Madison and Minnelusa aquifers are in concentrations of sulfate within the Minnelusa aquifer. Sulfate concentrations increase dramatically near a transition zone where dissolution of anhydrite is actively occurring. Water chemistry for the Madison and Minnelusa aquifers is controlled by reactions among calcite, dolomite, and anhydrite. Saturation indices for gypsum, calcite, and dolomite for most samples in both the Madison and Minnelusa aquifers are indicative of the occurrence of dedolomitization. Because water in the Madison aquifer remains undersaturated with respect to gypsum, even at the highest sulfate concentrations, upward leakage into the overlying Minnelusa aquifer has potential to drive increased dissolution of anhydrite in the Minnelusa Formation. Isotopic information is used to evaluate ground-water flowpaths, ages, and mixing conditions for the Madison and Minnelusa aquifers. Distinctive patterns exist in the distribution of stable isotopes of oxygen and hydrogen in precipitation for the Black Hills area, with isotopically lighter precipitation generally occurring at higher elevations and latitudes. Distributions of 18O in ground water are consistent with spatial patterns in recharge areas, with isotopically lighter 18O values in the Madison aquifer resulting from generally higher elevation recharge sources, relative to the Minnelusa aquifer. Three conceptual models, which are simplifications of lumped-parameter models, are considered for evaluation of mixing conditions and general ground-water ages. For a simple slug-flow model, which assumes no mixing, measured tritium concentrations in ground water can be related through a first-order decay equation to estimated concentrations at the time of recharge. Two simplified mixing models that assume equal proportions of annual recharge over a range of years also are considered. An ?immediate-arrival? model is used to conceptually represent conditions in outcrop areas and a ?time-delay? model is used for locations removed from outcrops, where delay times for earliest arrival of ground water generally would be expected. Because of limitations associated with estimating tritium input and gross simplifying assumptions of equal annual recharge and thorough mixing conditions, the conceptual models are used only for general evaluation of mixing conditions and approximation of age ranges. Headwater springs, which are located in or near outcrop areas, have the highest tritium concentrations, which is consistent with the immediate-arrival mixing model. Tritium concentrations for many wells are very low, or nondetectable, indicating general applicability of the timedelay conceptual model for locations beyond outcrop areas, where artesian conditions generally occur. Concentrations for artesian springs generally are higher than for wells, which indicates generally shorter delay times resulting from preferential flowpaths that typically are associated with artesian springs. In the Rapid City area, a distinct division of isotopic values for the Madison aquifer corresponds with distinguishing 18O signatures for nearby streams, where large streamflow recharge occurs. Previous dye testing in this area documented rapid ground-water flow (timeframe of weeks) from a streamflow loss zone to sites located several miles away. These results are used to ill

  17. Observations on SOFIA Observation Scheduling: Search and Inference in the Face of Discrete and Continuous Constraints

    NASA Technical Reports Server (NTRS)

    Frank, Jeremy; Gross, Michael; Kuerklu, Elif

    2003-01-01

    We did cool stuff to reduce the number of IVPs and BVPs needed to schedule SOFIA by restricting the problem. The restriction costs us little in terms of the value of the flight plans we can build. The restriction allowed us to reformulate part of the search problem as a zero-finding problem. The result is a simplified planning model and significant savings in computation time.

  18. Ammonia photolysis and the greenhouse effect in the primordial atmosphere of the earth

    NASA Technical Reports Server (NTRS)

    Kuhn, W. R.; Atreya, S. K.

    1979-01-01

    Photochemical calculations indicate that in the prebiotic atmosphere of earth ammonia would have been irreversibly converted to N2 in less than 40 years if the ammonia surface mixing ratio were no more than 0.0001. However, if a continuous outgassing of ammonia were maintained, radiative-equilibrium calculations indicate that a surface mixing ratio of ammonia of 0.0001 or greater would provide a sufficient greenhouse effect to keep the surface temperature above freezing. With a 0.0001 mixing ratio of ammonia, 60% to 70% of the present-day solar luminosity would be adequate to maintain surface temperatures above freezing. A lower limit to the time constant for accumulation of an amount of nitrogen equivalent to the present day value is 10 my if the outgassing were such as to provide a continuous surface mixing ratio of ammonia of at least 0.00001.

  19. Development of a new continuous process for mixing of complex non-Newtonian fluids

    NASA Astrophysics Data System (ADS)

    Migliozzi, Simona; Mazzei, Luca; Sochon, Bob; Angeli, Panagiota; Thames Multiphase Team; Coral Project Collaboration

    2017-11-01

    Design of new continuous mixing operations poses many challenges, especially when dealing with highly viscous non-Newtonian fluids. Knowledge of complex rheological behaviour of the working mixture is crucial for development of an efficient process. In this work, we investigate the mixing performance of two different static mixers and the effects of the mixture rheology on the manufacturing of novel non-aqueous-based oral care products using experimental and computational fluid dynamic methods. The two liquid phases employed, i.e. a carbomer suspension in polyethylene glycol and glycerol, start to form a gel when they mix. We studied the structure evolution of the liquid mixture using time-resolved rheometry and we obtained viscosity rheograms at different phase ratios from pressure drop measurements in a customized mini-channel. The numerical results and rheological model were validated with experimental measurements carried out in a specifically designed setup. EPSRS-CORAL.

  20. Broadband multi-wavelength Brillouin lasers with an operating wavelength range of 1500–1600 nm generated by four-wave mixing in a dual wavelength Brillouin fiber laser cavity

    NASA Astrophysics Data System (ADS)

    Li, Q.; Jia, Z. X.; Weng, H. Z.; Li, Z. R.; Yang, Y. D.; Xiao, J. L.; Chen, S. W.; Huang, Y. Z.; Qin, W. P.; Qin, G. S.

    2018-05-01

    We demonstrate broadband multi-wavelength Brillouin lasers with an operating wavelength range of 1500–1600 nm and a frequency separation of ~9.28 GHz generated by four-wave mixing in a dual wavelength Brillouin fiber laser cavity. By using one continuous-wave laser as the pump source, multi-wavelength Brillouin lasers with an operating wavelength range of 1554–1574 nm were generated via cascaded Brillouin scattering and four-wave mixing. Interestingly, when pumped by two continuous-wave lasers with an appropriate frequency separation, the operating wavelength range of the multi-wavelength Brillouin lasers was increased to 1500–1600 nm due to cavity-enhanced cascaded four-wave mixing among the frequency components generated by two pump lasers in the dual wavelength Brillouin laser cavity.

  1. PDF turbulence modeling and DNS

    NASA Technical Reports Server (NTRS)

    Hsu, A. T.

    1992-01-01

    The problem of time discontinuity (or jump condition) in the coalescence/dispersion (C/D) mixing model is addressed in probability density function (pdf). A C/D mixing model continuous in time is introduced. With the continuous mixing model, the process of chemical reaction can be fully coupled with mixing. In the case of homogeneous turbulence decay, the new model predicts a pdf very close to a Gaussian distribution, with finite higher moments also close to that of a Gaussian distribution. Results from the continuous mixing model are compared with both experimental data and numerical results from conventional C/D models. The effect of Coriolis forces on compressible homogeneous turbulence is studied using direct numerical simulation (DNS). The numerical method used in this study is an eight order compact difference scheme. Contrary to the conclusions reached by previous DNS studies on incompressible isotropic turbulence, the present results show that the Coriolis force increases the dissipation rate of turbulent kinetic energy, and that anisotropy develops as the Coriolis force increases. The Taylor-Proudman theory does apply since the derivatives in the direction of the rotation axis vanishes rapidly. A closer analysis reveals that the dissipation rate of the incompressible component of the turbulent kinetic energy indeed decreases with a higher rotation rate, consistent with incompressible flow simulations (Bardina), while the dissipation rate of the compressible part increases; the net gain is positive. Inertial waves are observed in the simulation results.

  2. Method for continuous synthesis of metal oxide powders

    DOEpatents

    Berry, David A.; Haynes, Daniel J.; Shekhawat, Dushyant; Smith, Mark W.

    2015-09-08

    A method for the rapid and continuous production of crystalline mixed-metal oxides from a precursor solution comprised of a polymerizing agent, chelated metal ions, and a solvent. The method discharges solution droplets of less than 500 .mu.m diameter using an atomizing or spray-type process into a reactor having multiple temperature zones. Rapid evaporation occurs in a first zone, followed by mixed-metal organic foam formation in a second zone, followed by amorphous and partially crystalline oxide precursor formation in a third zone, followed by formation of the substantially crystalline mixed-metal oxide in a fourth zone. The method operates in a continuous rather than batch manner and the use of small droplets as the starting material for the temperature-based process allows relatively high temperature processing. In a particular embodiment, the first zone operates at 100-300.degree. C., the second zone operates at 300-700.degree. C., and the third operates at 700-1000.degree. C., and fourth zone operates at at least 700.degree. C. The resulting crystalline mixed-metal oxides display a high degree of crystallinity and sphericity with typical diameters on the order of 50 .mu.m or less.

  3. Calculation of free turbulent mixing by interaction approach.

    NASA Technical Reports Server (NTRS)

    Morel, T.; Torda, T. P.

    1973-01-01

    The applicability of Bradshaw's interaction hypothesis to two-dimensional free shear flows was investigated. According to it, flows with velocity extrema may be considered to consist of several interacting layers. The hypothesis leads to a new expression for the shear stress which removes the usual restriction that shear stress vanishes at the velocity extremum. The approach is based on kinetic energy and the length scale equations. The compressible flow equations are simplified by restriction to low Mach numbers, and the range of their applicability is discussed. The empirical functions of the turbulence model are found here to be correlated with the spreading rate of the shear layer. The analysis demonstrates that the interaction hypothesis is a workable concept.

  4. Dissipation in the superconducting mixed state in the presence of a small oscillatory magnetic-field component

    NASA Astrophysics Data System (ADS)

    Risse, M. P.; Aikele, M. G.; Doettinger, S. G.; Huebener, R. P.; Tsuei, C. C.; Naito, M.

    1997-06-01

    We have studied the electric resistivity in superconducting amorphous Mo3Si films in a perpendicular magnetic field B0+B1 sin ωt with B1<0 we observed perfectly Ohmic behavior at currents I<

  5. Simplified, inverse, ejector design tool

    NASA Technical Reports Server (NTRS)

    Dechant, Lawrence J.

    1993-01-01

    A simple lumped parameter based inverse design tool has been developed which provides flow path geometry and entrainment estimates subject to operational, acoustic, and design constraints. These constraints are manifested through specification of primary mass flow rate or ejector thrust, fully-mixed exit velocity, and static pressure matching. Fundamentally, integral forms of the conservation equations coupled with the specified design constraints are combined to yield an easily invertible linear system in terms of the flow path cross-sectional areas. Entrainment is computed by back substitution. Initial comparison with experimental and analogous one-dimensional methods show good agreement. Thus, this simple inverse design code provides an analytically based, preliminary design tool with direct application to High Speed Civil Transport (HSCT) design studies.

  6. Simplified jet fuel reaction mechanism for lean burn combustion application

    NASA Technical Reports Server (NTRS)

    Lee, Chi-Ming; Kundu, Krishna; Ghorashi, Bahman

    1993-01-01

    Successful modeling of combustion and emissions in gas turbine engine combustors requires an adequate description of the reaction mechanism. Detailed mechanisms contain a large number of chemical species participating simultaneously in many elementary kinetic steps. Current computational fluid dynamic models must include fuel vaporization, fuel-air mixing, chemical reactions, and complicated boundary geometries. A five-step Jet-A fuel mechanism which involves pyrolysis and subsequent oxidation of paraffin and aromatic compounds is presented. This mechanism is verified by comparing with Jet-A fuel ignition delay time experimental data, and species concentrations obtained from flametube experiments. This five-step mechanism appears to be better than the current one- and two-step mechanisms.

  7. Optical properties of light absorbing carbon aggregates mixed with sulfate: assessment of different model geometries for climate forcing calculations.

    PubMed

    Kahnert, Michael; Nousiainen, Timo; Lindqvist, Hannakaisa; Ebert, Martin

    2012-04-23

    Light scattering by light absorbing carbon (LAC) aggregates encapsulated into sulfate shells is computed by use of the discrete dipole method. Computations are performed for a UV, visible, and IR wavelength, different particle sizes, and volume fractions. Reference computations are compared to three classes of simplified model particles that have been proposed for climate modeling purposes. Neither model matches the reference results sufficiently well. Remarkably, more realistic core-shell geometries fall behind homogeneous mixture models. An extended model based on a core-shell-shell geometry is proposed and tested. Good agreement is found for total optical cross sections and the asymmetry parameter. © 2012 Optical Society of America

  8. Ultrasonic Doppler measurement of renal artery blood flow

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Implantable pulsed Doppler ultrasonic flowmeter development has resulted in designs for application to the aortas of dogs and humans, and to human renal and coronary arteries. A figure of merit was derived for each design, indicating the degree of its precision. An H-array design for transcutaneous observation of blood flow was developed and tested in vitro. Two other simplified designs for the same purpose obviate the need to determine vessel orientation. One of these will be developed in the next time period. Techniques for intraoperative use and for implantation have had mixed success. While satisfactory on large vessels, higher ultrasonic frequencies and alteration of transducer design are required for satisfactory operation of pulsed Doppler flowmeters with small vessels.

  9. The Critically Ill Infant with Congenital Heart Disease.

    PubMed

    Strobel, Ashley M; Lu, Le N

    2015-08-01

    This article presents an approach for identification of infants with congenital heart disorders. These disorders are difficult to diagnose because of the complexity and variety of cardiac malformations; additionally presentation can be complicated by age-dependent physiology. By compiling data from the history and the physical examination, the emergency physician can identify lesion category and initiate stabilization procedures. Critical congenital cardiac lesions can be classified as left-sided obstructive ductal dependent, right-sided obstructive ductal dependent, and shunting or mixing. The simplified approach categorizes infants with these lesions respectively as "pink," "blue," or "gray." The emergency provider can provide life-saving stabilization until specialized care can be obtained. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. The technology of grating laser Doppler velocimeter for measuring transverse velocity of objects

    NASA Astrophysics Data System (ADS)

    Zhang, Shu; Lu, Guangfeng; Fan, Zhenfang; Luo, Hui

    2014-12-01

    In order to lower production cost of Laser Doppler velocimeter (LDV) and simplify the system structure, a grating Doppler detection system has been designed. This LDV was carried out by differential measurement mode. Two beams of diffracted light from the grating are mixed, and the beat frequency will be detected by a detector when the grating is moving. Fundamentals also have been introduced and partial experiment results of this system are given out. The result indicates the experimental value is agreement with the theoretical value. Errors have been analyzed and the main factors affecting the accuracy were discussed. Upon inspection, the inexpensive and ease LDV is efficient to administer and feasible.

  11. Mixer-Ejector Wind Turbine: Breakthrough High Efficiency Shrouded Wind Turbine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2010-02-22

    Broad Funding Opportunity Announcement Project: FloDesign Wind Turbine’s innovative wind turbine, inspired by the design of jet engines, could deliver 300% more power than existing wind turbines of the same rotor diameter by extracting more energy over a larger area. FloDesign Wind Turbine’s unique shrouded design expands the wind capture area, and the mixing vortex downstream allows more energy to flow through the rotor without stalling the turbine. The unique rotor and shrouded design also provide significant opportunity for mass production and simplified assembly, enabling mid-scale turbines (approximately 100 kW) to produce power at a cost that is comparable tomore » larger-scale conventional turbines.« less

  12. Memory-Intensive Benchmarks: IRAM vs. Cache-Based Machines

    NASA Technical Reports Server (NTRS)

    Biswas, Rupak; Gaeke, Brian R.; Husbands, Parry; Li, Xiaoye S.; Oliker, Leonid; Yelick, Katherine A.; Biegel, Bryan (Technical Monitor)

    2002-01-01

    The increasing gap between processor and memory performance has lead to new architectural models for memory-intensive applications. In this paper, we explore the performance of a set of memory-intensive benchmarks and use them to compare the performance of conventional cache-based microprocessors to a mixed logic and DRAM processor called VIRAM. The benchmarks are based on problem statements, rather than specific implementations, and in each case we explore the fundamental hardware requirements of the problem, as well as alternative algorithms and data structures that can help expose fine-grained parallelism or simplify memory access patterns. The benchmarks are characterized by their memory access patterns, their basic control structures, and the ratio of computation to memory operation.

  13. Intermixing in Cu/Ni multilayers induced by cold rolling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Z.; Perepezko, J. H., E-mail: perepezk@engr.wisc.edu; Larson, D.

    2015-04-28

    Repeated cold rolling was performed on multilayers of Cu60/Ni40 and Cu40/Ni60 foil arrays to study the details of driven atomic scale interfacial mixing. With increasing deformation, there is a significant layer refinement down to the nm level that leads to the formation of a solid solution phase from the elemental end members. Intriguingly, the composition of the solid solution is revealed by an oscillation in the composition profile across the multilayers, which is different from the smoothly varying profile due to thermally activated diffusion. During the reaction, Cu mixed into Ni preferentially compared to Ni mixing into Cu, which ismore » also in contrast to the thermal diffusion behavior. This is confirmed by observations from X-ray diffraction, electron energy loss spectrum and atom probe tomography. The diffusion coefficient induced by cold rolling is estimated as 1.7 × 10{sup −17} m{sup 2}/s, which cannot be attributed to any thermal effect. The effective temperature due to the deformation induced mixing is estimated as 1093 K and an intrinsic diffusivity d{sub b}, which quantifies the tendency towards equilibrium in the absence of thermal diffusion, is estimated as 6.38 × 10{sup −18} m{sup 2}/s. The fraction of the solid solution phase formed is illustrated by examining the layer thickness distribution and is described by using an error function representation. The evolution of mixing in the solid solution phase is described by a simplified sinusoid model, in which the amplitude decays with increased deformation level. The promoted diffusion coefficient could be related to the effective temperature concept, but the establishment of an oscillation in the composition profile is a characteristic behavior that develops due to deformation.« less

  14. 29 CFR 1614.303 - Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 4 2012-07-01 2012-07-01 false Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. 1614.303 Section 1614.303 Labor Regulations Relating to Labor (Continued) EQUAL... Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. (a) Who may file...

  15. 29 CFR 1614.303 - Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. 1614.303 Section 1614.303 Labor Regulations Relating to Labor (Continued) EQUAL... Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. (a) Who may file...

  16. 29 CFR 1614.303 - Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 4 2013-07-01 2013-07-01 false Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. 1614.303 Section 1614.303 Labor Regulations Relating to Labor (Continued) EQUAL... Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. (a) Who may file...

  17. 29 CFR 1614.303 - Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 4 2014-07-01 2014-07-01 false Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. 1614.303 Section 1614.303 Labor Regulations Relating to Labor (Continued) EQUAL... Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. (a) Who may file...

  18. 29 CFR 1614.303 - Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 4 2011-07-01 2011-07-01 false Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. 1614.303 Section 1614.303 Labor Regulations Relating to Labor (Continued) EQUAL... Petitions to the EEOC from MSPB decisions on mixed case appeals and complaints. (a) Who may file...

  19. A corrected formulation for marginal inference derived from two-part mixed models for longitudinal semi-continuous data

    PubMed Central

    Su, Li; Farewell, Vernon T

    2013-01-01

    For semi-continuous data which are a mixture of true zeros and continuously distributed positive values, the use of two-part mixed models provides a convenient modelling framework. However, deriving population-averaged (marginal) effects from such models is not always straightforward. Su et al. presented a model that provided convenient estimation of marginal effects for the logistic component of the two-part model but the specification of marginal effects for the continuous part of the model presented in that paper was based on an incorrect formulation. We present a corrected formulation and additionally explore the use of the two-part model for inferences on the overall marginal mean, which may be of more practical relevance in our application and more generally. PMID:24201470

  20. Calibrating binary lumped parameter models

    NASA Astrophysics Data System (ADS)

    Morgenstern, Uwe; Stewart, Mike

    2017-04-01

    Groundwater at its discharge point is a mixture of water from short and long flowlines, and therefore has a distribution of ages rather than a single age. Various transfer functions describe the distribution of ages within the water sample. Lumped parameter models (LPMs), which are mathematical models of water transport based on simplified aquifer geometry and flow configuration can account for such mixing of groundwater of different age, usually representing the age distribution with two parameters, the mean residence time, and the mixing parameter. Simple lumped parameter models can often match well the measured time varying age tracer concentrations, and therefore are a good representation of the groundwater mixing at these sites. Usually a few tracer data (time series and/or multi-tracer) can constrain both parameters. With the building of larger data sets of age tracer data throughout New Zealand, including tritium, SF6, CFCs, and recently Halon-1301, and time series of these tracers, we realised that for a number of wells the groundwater ages using a simple lumped parameter model were inconsistent between the different tracer methods. Contamination or degradation of individual tracers is unlikely because the different tracers show consistent trends over years and decades. This points toward a more complex mixing of groundwaters with different ages for such wells than represented by the simple lumped parameter models. Binary (or compound) mixing models are able to represent a more complex mixing, with mixing of water of two different age distributions. The problem related to these models is that they usually have 5 parameters which makes them data-hungry and therefore difficult to constrain all parameters. Two or more age tracers with different input functions, with multiple measurements over time, can provide the required information to constrain the parameters of the binary mixing model. We obtained excellent results using tritium time series encompassing the passage of the bomb-tritium through the aquifer, and SF6 with its steep gradient currently in the input. We will show age tracer data from drinking water wells that enabled identification of young water ingression into wells, which poses the risk of bacteriological contamination from the surface into the drinking water.

  1. Encouraging resilience within SMEs: the Cabinet Office's proposed approach.

    PubMed

    Sterling, Stuart

    2011-06-01

    This paper introduces the Cabinet Office's Civil Contingencies Secretariat (CCS). It explains how the National Risk Assessment, produced within the CCS, is created and used. As part of the recent Strategic Defence and Security Review, the Government made a commitment to improve the business continuity of small and medium-sized enterprises (SMEs).This paper describes the CCS's approach to achieving this, and explains why the resilience of SMEs is important to both local communities, at a time of disruption or crisis, and the essential services sectors, such as energy, food and transport. It provides an outline of a strategic approach that will seek to simplify business continuity by making it accessible, achievable and affordable, and, in partnership with the organisations that SMEs turn to for advice, promotes the benefits of business continuity and encourages its use.

  2. Method of chaotic mixing and improved stirred tank reactors

    DOEpatents

    Muzzio, F.J.; Lamberto, D.J.

    1999-07-13

    The invention provides a method and apparatus for efficiently achieving a homogeneous mixture of fluid components by introducing said components having a Reynolds number of between about [le]1 to about 500 into a vessel and continuously perturbing the mixing flow by altering the flow speed and mixing time until homogeneity is reached. This method prevents the components from aggregating into non-homogeneous segregated regions within said vessel during mixing and substantially reduces the time the admixed components reach homogeneity. 19 figs.

  3. Method of chaotic mixing and improved stirred tank reactors

    DOEpatents

    Muzzio, Fernando J.; Lamberto, David J.

    1999-01-01

    The invention provides a method and apparatus for efficiently achieving a homogeneous mixture of fluid components by introducing said components having a Reynolds number of between about .ltoreq.1 to about 500 into a vessel and continuously perturbing the mixing flow by altering the flow speed and mixing time until homogeniety is reached. This method prevents the components from aggregating into non-homogeneous segregated regions within said vessel during mixing and substantially reduces the time the admixed components reach homogeneity.

  4. 3D nanomolding and fluid mixing in micromixers with micro-patterned microchannel walls

    NASA Astrophysics Data System (ADS)

    Farshchian, Bahador; Amirsadeghi, Alborz; Choi, Junseo; Park, Daniel S.; Kim, Namwon; Park, Sunggook

    2017-03-01

    Microfluidic devices where the microchannel walls were decorated with micro and nanostructures were fabricated using 3D nanomolding. Using 3D molded microfluidic devices with microchannel walls decorated with microscale gratings, the fluid mixing behavior was investigated through experiments and numerical simulation. The use of microscale gratings in the micromixer was predicated by the fact that large obstacles in a microchannel enhances the mixing performance. Slanted ratchet gratings on the channel walls resulted in a helical flow along the microchannel, thus increasing the interfacial area between fluids and cutting down the diffusion length. Increasing the number of walls decorated with continuous ratchet gratings intensified the strength of the helical flow, enhancing mixing further. When ratchet gratings on the surface of the top cover plate were aligned in a direction to break the continuity of gratings from the other three walls, a stack of two helical flows was formed one above each other. This work concludes that the 3D nanomolding process can be a cost-effective tool for scaling-up the fabrication of microfluidic mixers with improved mixing efficiencies.[Figure not available: see fulltext.

  5. Continuous nanoparticle production by microfluidic-based emulsion, mixing and crystallization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Su, Y.-F.; Kim, H.; Kovenklioglu, S.

    2007-09-15

    BaSO{sub 4} and 2,2'-dipyridylamine (DPA) nanoparticles were synthesized as reactive crystallization and anti-solvent recrystallization examples, respectively, of using the microfluidic-based emulsion and mixing approach as a new avenue of continuously producing inorganic and organic nanoparticles. BaSO{sub 4} nanoparticles in the size range of 15-100 nm were reactively precipitated within the confinement of an aqueous droplet which was coalesced from two separate aqueous droplets containing BaCl{sub 2} and (NH{sub 4}){sub 2}SO{sub 4} using a three T-junction micromixer configuration constructed with commercially available simple tubing and fitting supplies. Also, DPA nanoparticles of about 200 nm were crystallized by combining DPA+ethanol and watermore » droplets using the same micromixer configuration. - Graphical abstract: BaSO{sub 4} and 2,2'-dipyridylamine (DPA) nanoparticles were synthesized as reactive crystallization and anti-solvent recrystallization examples, respectively, of using the microfluidic-based emulsion and mixing approach as a new avenue of continuously producing inorganic and organic nanoparticles.« less

  6. Productivity Measures Associated With a Patient Access Initiative

    PubMed Central

    Gable, William H.; Pappas, Theodore N.; Jacobs, Danny O.; Cutler, Desmond A.; Kuo, Paul C.

    2006-01-01

    Objective: To assess financial performance associated with a patient 7-day access initiative. Background Data: Patient access to clinical services is frequently an obstacle at academic medical centers. Conflicting surgeon priorities among academic, clinical, educational, and leadership duties often create difficulties for patient entry into the “system.” Methods: The scope and objectives were identified to be: design of a standard, simple new patient appointment process, design of a standard process in cases where an appointment is not available in 7 days, use subspecialty team search capabilities, minimize/eliminate prescheduling requirements, centralize appointment scheduling, and creation and reporting of 7-day access metrics. Following maturation of the process, the 7-day access metrics from the period July 2004 to December 2004 and January 2005 to June 2005 were compared with corresponding time periods from calendar years 2001, 2002, and 2003. Results: Payor mix was unaltered. The median waiting time for a new patient appointment decreased from 21 days to 10 days. When compared with calendar years 2001, 2002, and 2003, respectively, the 2 periods of the 7-day access initiative in calendar years 2004 and 2005 were associated with significantly increased visits, new patients, operative procedures, hospital charges, and physician charges. Conclusions: Implementation of a 7-day access initiative can significantly increase financial productivity of general surgery groups in academic medical centers. We conclude that simplifying access to services can benefit academic surgical practices. Sustaining this level of productivity will continue to prove challenging. PMID:16632994

  7. Exploring the use of I/O nodes for computation in a MIMD multiprocessor

    NASA Technical Reports Server (NTRS)

    Kotz, David; Cai, Ting

    1995-01-01

    As parallel systems move into the production scientific-computing world, the emphasis will be on cost-effective solutions that provide high throughput for a mix of applications. Cost effective solutions demand that a system make effective use of all of its resources. Many MIMD multiprocessors today, however, distinguish between 'compute' and 'I/O' nodes, the latter having attached disks and being dedicated to running the file-system server. This static division of responsibilities simplifies system management but does not necessarily lead to the best performance in workloads that need a different balance of computation and I/O. Of course, computational processes sharing a node with a file-system service may receive less CPU time, network bandwidth, and memory bandwidth than they would on a computation-only node. In this paper we begin to examine this issue experimentally. We found that high performance I/O does not necessarily require substantial CPU time, leaving plenty of time for application computation. There were some complex file-system requests, however, which left little CPU time available to the application. (The impact on network and memory bandwidth still needs to be determined.) For applications (or users) that cannot tolerate an occasional interruption, we recommend that they continue to use only compute nodes. For tolerant applications needing more cycles than those provided by the compute nodes, we recommend that they take full advantage of both compute and I/O nodes for computation, and that operating systems should make this possible.

  8. Waste Management Improvement Initiatives at Atomic Energy of Canada Limited - 13091

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chan, Nicholas; Adams, Lynne; Wong, Pierre

    2013-07-01

    Atomic Energy of Canada Limited's (AECL) Chalk River Laboratories (CRL) has been in operation for over 60 years. Radioactive, mixed, hazardous and non-hazardous wastes have been and continue to be generated at CRL as a result of research and development, radioisotope production, reactor operation and facility decommissioning activities. AECL has implemented several improvement initiatives at CRL to simplify the interface between waste generators and waste receivers: - Introduction of trained Waste Officers representing their facilities or activities at CRL; - Establishment of a Waste Management Customer Support Service as a Single-Point of Contact to provide guidance to waste generators formore » all waste management processes; and - Implementation of a streamlined approach for waste identification with emphasis on early identification of waste types and potential disposition paths. As a result of implementing these improvement initiatives, improvements in waste management and waste transfer efficiencies have been realized at CRL. These included: 1) waste generators contacting the Customer Support Service for information or guidance instead of various waste receivers; 2) more clear and consistent guidance provided to waste generators for waste management through the Customer Support Service; 3) more consistent and correct waste information provided to waste receivers through Waste Officers, resulting in reduced time and resources required for waste management (i.e., overall cost); 4) improved waste minimization and segregation approaches, as identified by in-house Waste Officers; and 5) enhanced communication between waste generators and waste management groups. (authors)« less

  9. A constitutive law for continuous fiber reinforced brittle matrix composites with fiber fragmentation and stress recovery

    NASA Astrophysics Data System (ADS)

    Neumeister, Jonas M.

    1993-08-01

    THE TENSILE BEHAVIOR of a brittle matrix composite is studied for post matrix crack saturation conditions. Scatter of fiber strength following the Weibull distribution as well as the influence of the major microstructural variables is considered. The stress in a fiber is assumed to recover linearly around a failure due to a fiber-matrix interface behavior mainly ruled by friction. The constitutive behavior for such a composite is analysed. Results are given for a simplified and a refined approximate description and compared with an analysis resulting from the exact analytical theory of fiber fragmentation. It is shown that the stress-strain relation for the refined model excellently follows the exact solution and gives the location of the maximum to within 1% in both stress and strain; for most materials the agreement is even better. Also it is shown that all relations can be normalized to depend on only two variables; a stress reference and the Weibull exponent. For systems with low scatter in fiber strength the simplified model is sufficient to determine the stress maximum but not the postcritical behavior. In addition, the simplified model gives explicit analytical expressions for the maximum stress and corresponding strain. None of the models contain any volume dependence or statistical scatter, but the maximum stress given by the stress-strain relation constitutes an upper bound for the ultimate tensile strength of the composite.

  10. Simplifying informed consent for biorepositories: stakeholder perspectives.

    PubMed

    Beskow, Laura M; Friedman, Joëlle Y; Hardy, N Chantelle; Lin, Li; Weinfurt, Kevin P

    2010-09-01

    Complex and sometimes controversial information must be conveyed during the consent process for participation in biorepositories, and studies suggest that consent documents in general are growing in length and complexity. As a first step toward creating a simplified biorepository consent form, we gathered data from multiple stakeholders about what information was most important for prospective participants to know when making a decision about taking part in a biorepository. We recruited 52 research participants, 12 researchers, and 20 institutional review board representatives from Durham and Kannapolis, NC. These subjects were asked to read a model biorepository consent form and highlight sentences they deemed most important. On average, institutional review board representatives identified 72.3% of the sentences as important; researchers selected 53.0%, and participants 40.4% (P = 0.0004). Participants most often selected sentences about the kinds of individual research results that might be offered, privacy risks, and large-scale data sharing. Researchers highlighted sentences about the biorepository's purpose, privacy protections, costs, and participant access to individual results. Institutional review board representatives highlighted sentences about collection of basic personal information, medical record access, and duration of storage. The differing mandates of these three groups can translate into widely divergent opinions about what information is important and appropriate to include a consent form. These differences could frustrate efforts to move simplified forms--for biobanking as well as for other kinds of research--into actual use, despite continued calls for such forms.

  11. Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips

    PubMed Central

    Jung, Woo-Chul; Heo, Young-Moo; Yoon, Gil-Sang; Shin, Kwang-Ho; Chang, Sung-Ho; Kim, Gun-Hee; Cho, Myeong-Woo

    2007-01-01

    Recently, the polymeric micro-fluidic biochip, often called LOC (lab-on-a-chip), has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. It becomes possible to form miniaturized lab functionalities on a chip with the development of MEMS technologies. The micro-fluidic chips contain many micro-channels for the flow of sample and reagents, mixing, and detection tasks. Typical substrate materials for the chip are glass and polymers. Typical techniques for microfluidic chip fabrication are utilizing various micro pattern forming methods, such as wet-etching, micro-contact printing, and hot-embossing, micro injection molding, LIGA, and micro powder blasting processes, etc. In this study, to establish the basis of the micro pattern fabrication and mass production of polymeric micro-fluidic chips using injection molding process, micro machining method was applied to form micro-channels on the LOC molds. In the research, a series of machining experiments using micro end-mills were performed to determine optimum machining conditions to improve surface roughness and shape accuracy of designed simplified micro-channels. Obtained conditions were used to machine required mold inserts for micro-channels using micro end-mills. Test injection processes using machined molds and COC polymer were performed, and then the results were investigated.

  12. Quantitative Real-Time PCR using the Thermo Scientific Solaris qPCR Assay

    PubMed Central

    Ogrean, Christy; Jackson, Ben; Covino, James

    2010-01-01

    The Solaris qPCR Gene Expression Assay is a novel type of primer/probe set, designed to simplify the qPCR process while maintaining the sensitivity and accuracy of the assay. These primer/probe sets are pre-designed to >98% of the human and mouse genomes and feature significant improvements from previously available technologies. These improvements were made possible by virtue of a novel design algorithm, developed by Thermo Scientific bioinformatics experts. Several convenient features have been incorporated into the Solaris qPCR Assay to streamline the process of performing quantitative real-time PCR. First, the protocol is similar to commonly employed alternatives, so the methods used during qPCR are likely to be familiar. Second, the master mix is blue, which makes setting the qPCR reactions easier to track. Third, the thermal cycling conditions are the same for all assays (genes), making it possible to run many samples at a time and reducing the potential for error. Finally, the probe and primer sequence information are provided, simplifying the publication process. Here, we demonstrate how to obtain the appropriate Solaris reagents using the GENEius product search feature found on the ordering web site (www.thermo.com/solaris) and how to use the Solaris reagents for performing qPCR using the standard curve method. PMID:20567213

  13. Tuning of quantum entanglement in molecular quantum cellular automata based on mixed-valence tetrameric units.

    PubMed

    Palii, Andrew; Tsukerblat, Boris

    2016-10-25

    In this article we consider two coupled tetrameric mixed-valence (MV) units accommodating electron pairs, which play the role of cells in molecular quantum cellular automata. It is supposed that the Coulombic interaction between instantly localized electrons within the cell markedly inhibits the transfer processes between the redox centers. Under this condition, as well as due to the vibronic localization of the electron pair, the cell can encode binary information, which is controlled by neighboring cells. We show that under certain conditions the two low-lying vibronic spin levels of the cell (ground and first excited states) can be regarded as originating from an effective spin-spin interaction. This is shown to depend on the internal parameters of the cell as well as on the induced polarization. Within this simplified two-level picture we evaluate the quantum entanglement in the system represented by the two electrons in the cell and show how the entanglement within the cell and concurrence can be controlled via polarization of the neighboring cells and temperature.

  14. Sintering Process and Mechanical Property of MWCNTs/HDPE Bulk Composite

    PubMed Central

    Tze-Chi, Hsu; Jie-Ren, Zheng

    2009-01-01

    Studies have proved that increasing polymer matrices by carbon nanotubes to form structural reinforcement and electrical conductivity have significantly improved mechanical and electrical properties at very low carbon nanotubes loading. In other words, increasing polymer matrices by carbon nanotubes to form structural reinforcement can reduce friction coefficient and enhance anti-wear property. However, producing traditional MWCNTs in polymeric materix is an extremely complicated process. Using melt-mixing process or in situ polymerization leads to better dispersion effect on composite materials. In this study, therefore, to simplify MWCNTs /HDPE composite process and increase dispersion, powder was used directly to replace pellet to mix and sinter with MWCNTs. The composite bulks with 0, 0.5, 1, 2 and 4% nanotube content by weight was analyzed under SEM to observe nanotubes dispersion. At this rate, a MWCNTs/HDPE composite bulk with uniformly dispersed MWCNTs was achieved, and through the wear bench (Pin-on-Disk), the wear experiment has accomplished. Accordingly, the result suggests the sintered MWCNTs/HDPE composites amplify the hardness and wear-resist property. PMID:19730688

  15. Effects of moving-vehicle wakes on pollutant dispersion inside a highway road tunnel.

    PubMed

    Bhautmage, Utkarsh; Gokhale, Sharad

    2016-11-01

    This study investigates the pollutant dispersion in a highway road tunnel in the presence of moving-vehicle wakes by a relative-velocity approach using 3-D CFD (3-Dimensional Computational Fluid Dynamics). The turbulent behavior of airflow around different-shaped vehicles and its impact on the pollutant dispersion have been studied. The different-shaped vehicle geometries were extracted, and simplified and dimensioned basing the typical vehicles on Indian roads. The model has been verified with the literature data of static pressure around a moving vehicle body before applying to simulate concentrations, and validated with on-site data at two locations. The results showed that wakes varied with the size, shape and speed of vehicles. The mixed-traffic flow produced higher near-field wakes and accelerated the piston effect, pushing pollutants toward the tunnel roof and out of exit portal in short-time. The findings have particular significance in the studies related to dispersion inside the tunnels having a mixed traffic of different dimensions and shape. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Isoniazid Preventive Therapy among Children Living with Tuberculosis Patients: Is It Working? A Mixed-Method Study from Bhopal, India

    PubMed Central

    Singh, Akash Ranjan; Kharate, Atul; Bhat, Prashant; Kokane, Arun M; Bali, Surya; Sahu, Swaroop; Verma, Manoj; Nagar, Mukesh; Kumar, Ajay MV

    2017-01-01

    Abstract Objective We assessed uptake of isoniazid preventive therapy (IPT) among child contacts of smear-positive tuberculosis (TB) patients and its implementation challenges from healthcare providers’ and parents’ perspectives in Bhopal, India. Methods A mixed-method study design: quantitative phase (review of programme records and house-to-house survey of smear-positive TB patients) followed by qualitative phase (interviews of healthcare providers and parents). Results Of 59 child contacts (<6 years) of 129 index patients, 51 were contacted. Among them, 19 of 51 (37%) were screened for TB and one had TB. Only 11 of 50 (22%) children were started and 10 of 50 (20%) completed IPT. Content analysis of interviews revealed lack of awareness, risk perception among parents, cumbersome screening process, isoniazid stock-outs, inadequate knowledge among healthcare providers and poor programmatic monitoring as main barriers to IPT implementation. Conclusion National TB programme should counsel parents, train healthcare providers, simplify screening procedures, ensure regular drug supply and introduce an indicator to strengthen monitoring and uptake of IPT. PMID:28082666

  17. A novel approach to mixing qualitative and quantitative methods in HIV and STI prevention research.

    PubMed

    Penman-Aguilar, Ana; Macaluso, Maurizio; Peacock, Nadine; Snead, M Christine; Posner, Samuel F

    2014-04-01

    Mixed-method designs are increasingly used in sexually transmitted infection (STI) and HIV prevention research. The authors designed a mixedmethod approach and applied it to estimate and evaluate a predictor of continued female condom use (6+ uses, among those who used it at least once) in a 6-month prospective cohort study. The analysis included 402 women who received an intervention promoting use of female and male condoms for STI prevention and completed monthly quantitative surveys; 33 also completed a semistructured qualitative interview. The authors identified a qualitative theme (couples' female condom enjoyment [CFCE]), applied discriminant analysis techniques to estimate CFCE for all participants, and added CFCE to a multivariable logistic regression model of continued female condom use. CFCE related to comfort, naturalness, pleasure, feeling protected, playfulness, ease of use, intimacy, and feeling in control of protection. CFCE was associated with continued female condom use (adjusted odds ratio: 2.8, 95% confidence interval: 1.4-5.6) and significantly improved model fit (p < .001). CFCE predicted continued female condom use. Mixed-method approaches for "scaling up" qualitative findings from small samples to larger numbers of participants can benefit HIV and STI prevention research.

  18. Maximum-Likelihood Detection Of Noncoherent CPM

    NASA Technical Reports Server (NTRS)

    Divsalar, Dariush; Simon, Marvin K.

    1993-01-01

    Simplified detectors proposed for use in maximum-likelihood-sequence detection of symbols in alphabet of size M transmitted by uncoded, full-response continuous phase modulation over radio channel with additive white Gaussian noise. Structures of receivers derived from particular interpretation of maximum-likelihood metrics. Receivers include front ends, structures of which depends only on M, analogous to those in receivers of coherent CPM. Parts of receivers following front ends have structures, complexity of which would depend on N.

  19. Neural Network Classifies Teleoperation Data

    NASA Technical Reports Server (NTRS)

    Fiorini, Paolo; Giancaspro, Antonio; Losito, Sergio; Pasquariello, Guido

    1994-01-01

    Prototype artificial neural network, implemented in software, identifies phases of telemanipulator tasks in real time by analyzing feedback signals from force sensors on manipulator hand. Prototype is early, subsystem-level product of continuing effort to develop automated system that assists in training and supervising human control operator: provides symbolic feedback (e.g., warnings of impending collisions or evaluations of performance) to operator in real time during successive executions of same task. Also simplifies transition between teleoperation and autonomous modes of telerobotic system.

  20. Impact of a simplified in situ protocol on enamel loss after erosive challenge

    PubMed Central

    Buzalaf, Marília Afonso Rabelo; Oliveira, Thais Marchini; Honório, Heitor Marques; Cruvinel, Thiago

    2018-01-01

    This study investigated the effect of the period of use and location of intraoral appliances on enamel surface loss. This randomized, single blind in situ study was conducted in 2 crossover phases based on the period of use, in which maxillary and mandibular appliances were simultaneously worn. Bovine enamel blocks (n = 120) were randomly divided among the studied groups by surface hardness. In each phase, fifteen volunteers used one maxillary appliance and two mandibular appliances for 5 days. Erosive challenge was performed 4X/day by immersion in 0.01 M HCL for 2 minutes. In the continuous phase, the intraoral appliances were worn for 20 hours. In the intermittent phase the appliances were worn for 8 hours and 30 minutes. Enamel loss was determined profilometrically. The discomfort of use of the appliances were evaluated in a questionnaire. Data were analyzed by two-way ANOVA/Tukey’s test and chi-square test (p<0.05). The maxillary appliance promoted higher enamel loss compared to the mandibular one (p<0.001). Intermittent use of appliances resulted in similar enamel loss to the continuous one (p = 0.686). All volunteers preferred to use the maxillary appliance in an intermittent regimen. The intermittent use of maxillary appliance is a simplified reliable protocol appropriated for in situ erosion studies in enamel. PMID:29734362

  1. Integrodifferential formulations of the continuous-time random walk for solute transport subject to bimolecular A +B →0 reactions: From micro- to mesoscopic

    NASA Astrophysics Data System (ADS)

    Hansen, Scott K.; Berkowitz, Brian

    2015-03-01

    We develop continuous-time random walk (CTRW) equations governing the transport of two species that annihilate when in proximity to one another. In comparison with catalytic or spontaneous transformation reactions that have been previously considered in concert with CTRW, both species have spatially variant concentrations that require consideration. We develop two distinct formulations. The first treats transport and reaction microscopically, potentially capturing behavior at sharp fronts, but at the cost of being strongly nonlinear. The second, mesoscopic, formulation relies on a separation-of-scales technique we develop to separate microscopic-scale reaction and upscaled transport. This simplifies the governing equations and allows treatment of more general reaction dynamics, but requires stronger smoothness assumptions of the solution. The mesoscopic formulation is easily tractable using an existing solution from the literature (we also provide an alternative derivation), and the generalized master equation (GME) for particles undergoing A +B →0 reactions is presented. We show that this GME simplifies, under appropriate circumstances, to both the GME for the unreactive CTRW and to the advection-dispersion-reaction equation. An additional major contribution of this work is on the numerical side: to corroborate our development, we develop an indirect particle-tracking-partial-integro-differential-equation (PIDE) hybrid verification technique which could be applicable widely in reactive anomalous transport. Numerical simulations support the mesoscopic analysis.

  2. On Displacement Height, from Classical to Practical Formulation: Stress, Turbulent Transport and Vorticity Considerations

    NASA Astrophysics Data System (ADS)

    Sogachev, Andrey; Kelly, Mark

    2016-03-01

    Displacement height ( d) is an important parameter in the simple modelling of wind speed and vertical fluxes above vegetative canopies, such as forests. Here we show that, aside from implicit definition through a (displaced) logarithmic profile, accepted formulations for d do not consistently predict flow properties above a forest. Turbulent transport can affect the displacement height, and is an integral part of what is called the roughness sublayer. We develop a more general approach for estimation of d, through production of turbulent kinetic energy and turbulent transport, and show how previous stress-based formulations for displacement height can be seen as simplified cases of a more general definition including turbulent transport. Further, we also give a simplified and practical form for d that is in agreement with the general approach, exploiting the concept of vortex thickness scale from mixing-layer theory. We assess the new and previous displacement height formulations by using flow statistics derived from the atmospheric boundary-layer Reynolds-averaged Navier-Stokes model SCADIS as well as from wind-tunnel observations, for different vegetation types and flow regimes in neutral conditions. The new formulations tend to produce smaller d than stress-based forms, falling closer to the classic logarithmically-defined displacement height. The new, more generally defined, displacement height appears to be more compatible with profiles of components of the turbulent kinetic energy budget, accounting for the combined effects of turbulent transport and shear production. The Coriolis force also plays a role, introducing wind-speed dependence into the behaviour of the roughness sublayer; this affects the turbulent transport, shear production, stress, and wind speed, as well as the displacement height, depending on the character of the forest. We further show how our practical (`mixing-layer') form for d matches the new turbulence-based relation, as well as correspondence to previous (stress-based) formulations.

  3. A new method to identify the foot of continental slope based on an integrated profile analysis

    NASA Astrophysics Data System (ADS)

    Wu, Ziyin; Li, Jiabiao; Li, Shoujun; Shang, Jihong; Jin, Xiaobin

    2017-06-01

    A new method is proposed to identify automatically the foot of the continental slope (FOS) based on the integrated analysis of topographic profiles. Based on the extremum points of the second derivative and the Douglas-Peucker algorithm, it simplifies the topographic profiles, then calculates the second derivative of the original profiles and the D-P profiles. Seven steps are proposed to simplify the original profiles. Meanwhile, multiple identification methods are proposed to determine the FOS points, including gradient, water depth and second derivative values of data points, as well as the concave and convex, continuity and segmentation of the topographic profiles. This method can comprehensively and intelligently analyze the topographic profiles and their derived slopes, second derivatives and D-P profiles, based on which, it is capable to analyze the essential properties of every single data point in the profile. Furthermore, it is proposed to remove the concave points of the curve and in addition, to implement six FOS judgment criteria.

  4. Simplified Computation for Nonparametric Windows Method of Probability Density Function Estimation.

    PubMed

    Joshi, Niranjan; Kadir, Timor; Brady, Michael

    2011-08-01

    Recently, Kadir and Brady proposed a method for estimating probability density functions (PDFs) for digital signals which they call the Nonparametric (NP) Windows method. The method involves constructing a continuous space representation of the discrete space and sampled signal by using a suitable interpolation method. NP Windows requires only a small number of observed signal samples to estimate the PDF and is completely data driven. In this short paper, we first develop analytical formulae to obtain the NP Windows PDF estimates for 1D, 2D, and 3D signals, for different interpolation methods. We then show that the original procedure to calculate the PDF estimate can be significantly simplified and made computationally more efficient by a judicious choice of the frame of reference. We have also outlined specific algorithmic details of the procedures enabling quick implementation. Our reformulation of the original concept has directly demonstrated a close link between the NP Windows method and the Kernel Density Estimator.

  5. A simplified procedure for correcting both errors and erasures of a Reed-Solomon code using the Euclidean algorithm

    NASA Technical Reports Server (NTRS)

    Truong, T. K.; Hsu, I. S.; Eastman, W. L.; Reed, I. S.

    1987-01-01

    It is well known that the Euclidean algorithm or its equivalent, continued fractions, can be used to find the error locator polynomial and the error evaluator polynomial in Berlekamp's key equation needed to decode a Reed-Solomon (RS) code. A simplified procedure is developed and proved to correct erasures as well as errors by replacing the initial condition of the Euclidean algorithm by the erasure locator polynomial and the Forney syndrome polynomial. By this means, the errata locator polynomial and the errata evaluator polynomial can be obtained, simultaneously and simply, by the Euclidean algorithm only. With this improved technique the complexity of time domain RS decoders for correcting both errors and erasures is reduced substantially from previous approaches. As a consequence, decoders for correcting both errors and erasures of RS codes can be made more modular, regular, simple, and naturally suitable for both VLSI and software implementation. An example illustrating this modified decoding procedure is given for a (15, 9) RS code.

  6. Influence of backup bearings and support structure dynamics on the behavior of rotors with active supports

    NASA Technical Reports Server (NTRS)

    Flowers, George T.

    1994-01-01

    Progress over the past year includes the following: A simplified rotor model with a flexible shaft and backup bearings has been developed. A simple rotor model which includes a flexible disk and bearings with clearance has been developed and the dynamics of the model investigated. A rotor model based upon the T-501 engine has been developed which includes backup bearing effects. Parallel simulation runs are being conducted using an ANSYS based finite element model of the T-501. The magnetic bearing test rig is currently floating and dynamics/control tests are being conducted. A paper has been written that documents the work using the T-501 engine model. Work has continued with the simplified model. The finite element model is currently being modified to include the effects of foundation dynamics. A literature search for material on foil bearings has been conducted. A finite element model is being developed for a magnetic bearing in series with a foil backup bearing.

  7. Rationale for the Use of CAD/CAM Technology in Implant Prosthodontics

    PubMed Central

    Abduo, Jaafar; Lyons, Karl

    2013-01-01

    Despite the predictable longevity of implant prosthesis, there is an ongoing interest to continue to improve implant prosthodontic treatment and outcomes. One of the developments is the application of computer-aided design and computer-aided manufacturing (CAD/CAM) to produce implant abutments and frameworks from metal or ceramic materials. The aim of this narrative review is to critically evaluate the rationale of CAD/CAM utilization for implant prosthodontics. To date, CAD/CAM allows simplified production of precise and durable implant components. The precision of fit has been proven in several laboratory experiments and has been attributed to the design of implants. Milling also facilitates component fabrication from durable and aesthetic materials. With further development, it is expected that the CAD/CAM protocol will be further simplified. Although compelling clinical evidence supporting the superiority of CAD/CAM implant restorations is still lacking, it is envisioned that CAD/CAM may become the main stream for implant component fabrication. PMID:23690778

  8. Agile green process design for the intensified Kolbe-Schmitt synthesis by accompanying (simplified) life cycle assessment.

    PubMed

    Kressirer, Sabine; Kralisch, Dana; Stark, Annegret; Krtschil, Ulrich; Hessel, Volker

    2013-05-21

    In order to investigate the potential for process intensification, various reaction conditions were applied to the Kolbe-Schmitt synthesis starting from resorcinol. Different CO₂ precursors such as aqueous potassium hydrogencarbonate, hydrogencarbonate-based ionic liquids, DIMCARB, or sc-CO₂, the application of microwave irradiation for fast volumetric heating of the reaction mixture, and the effect of harsh reaction conditions were investigated. The experiments, carried out in conventional batch-wise as well as in continuously operated microstructured reactors, aimed at the development of an environmentally benign process for the preparation of 2,4-dihydroxybenzoic acid. To provide decision support toward a green process design, a research-accompanying simplified life cycle assessment (SLCA) was performed throughout the whole investigation. Following this approach, it was found that convective heating methods such as oil bath or electrical heating were more beneficial than the application of microwave irradiation. Furthermore, the consideration of workup procedures was crucial for a holistic view on the environmental burdens.

  9. Flux-related and Critical Dilution Indices: Quantitative Indicators of Mixing and Mixing-controlled Reactions in Heterogeneous Porous Media

    NASA Astrophysics Data System (ADS)

    Chiogna, G.; Cirpka, O. A.; Grathwohl, P.; Rolle, M.

    2010-12-01

    The correct quantification of mixing is of utmost importance for modeling reactive transport in porous media and, thereby assessing the fate and transport of contaminants in the subsurface. An appropriate measure of mixing in heterogeneous porous formations should correctly capture the effects on mixing intensity of various processes at different scales, such as local dispersion and the effect of mixing enhancement due to heterogeneities. In this work, we use the concept of the flux-related dilution index as a measure of transverse mixing. This quantity expresses the dilution of the mass flux of a tracer solution over the total discharge of the system and is particularly suited to address problems where a compound is continuously injected into the domain. We focus our attention on two-dimensional systems under steady-state flow conditions and investigate both conservative and reactive transport in both homogeneous and heterogeneous porous media at different scales. For mixing-controlled reactive systems, we introduce and illustrate the concept of the critical dilution index, which represents the amount of mixing required for complete degradation of a continuously emitted plume undergoing decay upon mixing with ambient water. We perform two-dimensional numerical experiments at bench and field scales in homogeneous and heterogeneous conductivity fields. These numerical simulations show that the flux-related dilution index quantifies mixing and that the concept of the critical dilution index is a useful measure to relate the mixing of conservative tracers to mixing-controlled turnover of reactive compounds. In the end we define an effective transverse dispersion coefficient which is able to capture the main characteristics of the physical mechanisms controlling reactive transport at the field scale. Furthermore we investigated the influence of compound specific local transverse dispersion coefficients on the flux related dilution index and on the critical dilution index.

  10. 7 CFR 205.270 - Organic handling requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT..., heating, drying, mixing, grinding, churning, separating, distilling, extracting, slaughtering, cutting...

  11. 7 CFR 205.270 - Organic handling requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT..., heating, drying, mixing, grinding, churning, separating, distilling, extracting, slaughtering, cutting...

  12. A corrected formulation for marginal inference derived from two-part mixed models for longitudinal semi-continuous data.

    PubMed

    Tom, Brian Dm; Su, Li; Farewell, Vernon T

    2016-10-01

    For semi-continuous data which are a mixture of true zeros and continuously distributed positive values, the use of two-part mixed models provides a convenient modelling framework. However, deriving population-averaged (marginal) effects from such models is not always straightforward. Su et al. presented a model that provided convenient estimation of marginal effects for the logistic component of the two-part model but the specification of marginal effects for the continuous part of the model presented in that paper was based on an incorrect formulation. We present a corrected formulation and additionally explore the use of the two-part model for inferences on the overall marginal mean, which may be of more practical relevance in our application and more generally. © The Author(s) 2013.

  13. An Amino Acid Code for Irregular and Mixed Protein Packing

    PubMed Central

    Joo, Hyun; Chavan, Archana; Fraga, Keith; Tsai, Jerry

    2015-01-01

    To advance our understanding of protein tertiary structure, the development of the knob-socket model is completed in an analysis of the packing in irregular coil and turn secondary structure packing as well as between mixed secondary structure. The knob-socket model simplifies packing based on repeated patterns of 2 motifs: a 3 residue socket for packing within 2° structure and a 4 residue knob-socket for 3° packing. For coil and turn secondary structure, knob-sockets allow identification of a correlation between amino acid composition and tertiary arrangements in space. Coil contributes almost as much as α-helices to tertiary packing. Irregular secondary structure involves 3 residue cliques of consecutive contacting residues or XYZ sockets. In irregular sockets, Gly, Pro, Asp and Ser are favored, while Cys, His, Met and Trp are not. For irregular knobs, the preference order is Arg, Asp, Pro, Asn, Thr, Leu, and Gly, while Cys, His, Met and Trp are not. In mixed packing, the knob amino acid preferences are a function of the socket that they are packing into, whereas the amino acid composition of the sockets does not depend on the secondary structure of the knob. A unique motif of a coil knob with an XYZ β-sheet socket may potentially function to inhibit β-sheet extension. In addition, analysis of the preferred crossing angles for strands within a β-sheet and mixed α-helices/β-sheets identifies canonical packing patterns useful in protein design. Lastly, the knob-socket model abstracts the complexity of protein tertiary structure into an intuitive packing surface topology map. PMID:26370334

  14. Cold Electrons as the Drivers of Parallel, Electrostatic Waves in Asymmetric Reconnection

    NASA Astrophysics Data System (ADS)

    Holmes, J.; Ergun, R.; Newman, D. L.; Wilder, F. D.; Schwartz, S. J.; Goodrich, K.; Eriksson, S.; Torbert, R. B.; Russell, C. T.; Lindqvist, P. A.; Giles, B. L.; Pollock, C. J.; Le Contel, O.; Strangeway, R. J.; Burch, J. L.

    2016-12-01

    The Magnetospheric MultiScale mission (MMS) has observed several instances of asymmetric reconnection at Earth's magnetopause, where plasma from the magnetosheath encounters that of the magnetosphere. On Earth's dayside, the magnetosphere is often made up of a two-component distribution of cold (<< 10 eV) and hot ( 1 keV) plasma, sometimes including the cold ion plume. Magnetosheath plasma is primarily warm ( 100 eV) post-shock solar wind. Where they meet, magnetopause reconnection alters the magnetic topology such that these two populations are left cohabiting a field line and rapidly mix. There have been several events observed by MMS where the Fast Plasma Instrument (FPI) clearly shows cold ions near the diffusion region impinging upon the warm magnetosheath population. In many of these, we also see patches of strong electrostatic waves parallel to the magnetic field - a smoking gun for rapid mixing via nonlinear processes. Cold ions alone are too slow to create the same waves; solving for roots of a simplified dispersion relation shows the electron population damps out the ion modes. From this, we infer the presence of cold electrons; in one notable case found by Wilder et al. 2016 (in review), they have been observed directly by FPI. Vlasov simulations of plasma mixing for a number of these events closely reproduce the observed electric field signatures. We conclude from numerical analysis and direct MMS observations that cold plasma mixing, including cold electrons, is the primary driver of parallel electrostatic waves observed near the electron diffusion region in asymmetric magnetic reconnection.

  15. Random effects coefficient of determination for mixed and meta-analysis models

    PubMed Central

    Demidenko, Eugene; Sargent, James; Onega, Tracy

    2011-01-01

    The key feature of a mixed model is the presence of random effects. We have developed a coefficient, called the random effects coefficient of determination, Rr2, that estimates the proportion of the conditional variance of the dependent variable explained by random effects. This coefficient takes values from 0 to 1 and indicates how strong the random effects are. The difference from the earlier suggested fixed effects coefficient of determination is emphasized. If Rr2 is close to 0, there is weak support for random effects in the model because the reduction of the variance of the dependent variable due to random effects is small; consequently, random effects may be ignored and the model simplifies to standard linear regression. The value of Rr2 apart from 0 indicates the evidence of the variance reduction in support of the mixed model. If random effects coefficient of determination is close to 1 the variance of random effects is very large and random effects turn into free fixed effects—the model can be estimated using the dummy variable approach. We derive explicit formulas for Rr2 in three special cases: the random intercept model, the growth curve model, and meta-analysis model. Theoretical results are illustrated with three mixed model examples: (1) travel time to the nearest cancer center for women with breast cancer in the U.S., (2) cumulative time watching alcohol related scenes in movies among young U.S. teens, as a risk factor for early drinking onset, and (3) the classic example of the meta-analysis model for combination of 13 studies on tuberculosis vaccine. PMID:23750070

  16. Detecting single-trial EEG evoked potential using a wavelet domain linear mixed model: application to error potentials classification.

    PubMed

    Spinnato, J; Roubaud, M-C; Burle, B; Torrésani, B

    2015-06-01

    The main goal of this work is to develop a model for multisensor signals, such as magnetoencephalography or electroencephalography (EEG) signals that account for inter-trial variability, suitable for corresponding binary classification problems. An important constraint is that the model be simple enough to handle small size and unbalanced datasets, as often encountered in BCI-type experiments. The method involves the linear mixed effects statistical model, wavelet transform, and spatial filtering, and aims at the characterization of localized discriminant features in multisensor signals. After discrete wavelet transform and spatial filtering, a projection onto the relevant wavelet and spatial channels subspaces is used for dimension reduction. The projected signals are then decomposed as the sum of a signal of interest (i.e., discriminant) and background noise, using a very simple Gaussian linear mixed model. Thanks to the simplicity of the model, the corresponding parameter estimation problem is simplified. Robust estimates of class-covariance matrices are obtained from small sample sizes and an effective Bayes plug-in classifier is derived. The approach is applied to the detection of error potentials in multichannel EEG data in a very unbalanced situation (detection of rare events). Classification results prove the relevance of the proposed approach in such a context. The combination of the linear mixed model, wavelet transform and spatial filtering for EEG classification is, to the best of our knowledge, an original approach, which is proven to be effective. This paper improves upon earlier results on similar problems, and the three main ingredients all play an important role.

  17. Continuous Flow Science in an Undergraduate Teaching Laboratory: Bleach-Mediated Oxidation in a Biphasic System

    ERIC Educational Resources Information Center

    Kairouz, Vanessa; Collins, Shawn K.

    2018-01-01

    An undergraduate teaching laboratory experiment involving a continuous flow, bleach-mediated oxidation of aldehydes under biphasic conditions was developed that allowed students to explore concepts of mixing or mass transport, solvent sustainability, biphasic reactions, phase transfer catalysis, and continuous flow chemistry.

  18. Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing

    PubMed Central

    Ortiz de Solorzano, Isabel; Uson, Laura; Larrea, Ane; Miana, Mario; Sebastian, Victor; Arruebo, Manuel

    2016-01-01

    By using interdigital microfluidic reactors, monodisperse poly(d,l lactic-co-glycolic acid) nanoparticles (NPs) can be produced in a continuous manner and at a large scale (~10 g/h). An optimized synthesis protocol was obtained by selecting the appropriated passive mixer and fluid flow conditions to produce monodisperse NPs. A reduced NP polydispersity was obtained when using the microfluidic platform compared with the one obtained with NPs produced in a conventional discontinuous batch reactor. Cyclosporin, an immunosuppressant drug, was used as a model to validate the efficiency of the microfluidic platform to produce drug-loaded monodisperse poly(d,l lactic-co-glycolic acid) NPs. The influence of the mixer geometries and temperatures were analyzed, and the experimental results were corroborated by using computational fluid dynamic three-dimensional simulations. Flow patterns, mixing times, and mixing efficiencies were calculated, and the model supported with experimental results. The progress of mixing in the interdigital mixer was quantified by using the volume fractions of the organic and aqueous phases used during the emulsification–evaporation process. The developed model and methods were applied to determine the required time for achieving a complete mixing in each microreactor at different fluid flow conditions, temperatures, and mixing rates. PMID:27524896

  19. 3D nanomolding and fluid mixing in micromixers with micro-patterned microchannel walls.

    PubMed

    Farshchian, Bahador; Amirsadeghi, Alborz; Choi, Junseo; Park, Daniel S; Kim, Namwon; Park, Sunggook

    2017-01-01

    Microfluidic devices where the microchannel walls were decorated with micro and nanostructures were fabricated using 3D nanomolding. Using 3D molded microfluidic devices with microchannel walls decorated with microscale gratings, the fluid mixing behavior was investigated through experiments and numerical simulation. The use of microscale gratings in the micromixer was predicated by the fact that large obstacles in a microchannel enhances the mixing performance. Slanted ratchet gratings on the channel walls resulted in a helical flow along the microchannel, thus increasing the interfacial area between fluids and cutting down the diffusion length. Increasing the number of walls decorated with continuous ratchet gratings intensified the strength of the helical flow, enhancing mixing further. When ratchet gratings on the surface of the top cover plate were aligned in a direction to break the continuity of gratings from the other three walls, a stack of two helical flows was formed one above each other. This work concludes that the 3D nanomolding process can be a cost-effective tool for scaling-up the fabrication of microfluidic mixers with improved mixing efficiencies.Graphical abstractIn this paper we show that a micromixer with patterned walls can be fabricated using 3D nanomolding and solvent-assisted bonding to manipulate the flow patterns to improve mixing.

  20. Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing.

    PubMed

    Ortiz de Solorzano, Isabel; Uson, Laura; Larrea, Ane; Miana, Mario; Sebastian, Victor; Arruebo, Manuel

    2016-01-01

    By using interdigital microfluidic reactors, monodisperse poly(d,l lactic-co-glycolic acid) nanoparticles (NPs) can be produced in a continuous manner and at a large scale (~10 g/h). An optimized synthesis protocol was obtained by selecting the appropriated passive mixer and fluid flow conditions to produce monodisperse NPs. A reduced NP polydispersity was obtained when using the microfluidic platform compared with the one obtained with NPs produced in a conventional discontinuous batch reactor. Cyclosporin, an immunosuppressant drug, was used as a model to validate the efficiency of the microfluidic platform to produce drug-loaded monodisperse poly(d,l lactic-co-glycolic acid) NPs. The influence of the mixer geometries and temperatures were analyzed, and the experimental results were corroborated by using computational fluid dynamic three-dimensional simulations. Flow patterns, mixing times, and mixing efficiencies were calculated, and the model supported with experimental results. The progress of mixing in the interdigital mixer was quantified by using the volume fractions of the organic and aqueous phases used during the emulsification-evaporation process. The developed model and methods were applied to determine the required time for achieving a complete mixing in each microreactor at different fluid flow conditions, temperatures, and mixing rates.

  1. 40 CFR 721.10006 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mixed metal oxide (generic). 721.10006 Section 721.10006 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES...) of this section. (2) The significant new uses are: (i) Industrial, commercial, and consumer...

  2. Fluid dynamic analysis of a continuous stirred tank reactor for technical optimization of wastewater digestion.

    PubMed

    Hurtado, F J; Kaiser, A S; Zamora, B

    2015-03-15

    Continuous stirred tank reactors (CSTR) are widely used in wastewater treatment plants to reduce the organic matter and microorganism present in sludge by anaerobic digestion. The present study carries out a numerical analysis of the fluid dynamic behaviour of a CSTR in order to optimize the process energetically. The characterization of the sludge flow inside the digester tank, the residence time distribution and the active volume of the reactor under different criteria are determined. The effects of design and power of the mixing system on the active volume of the CSTR are analyzed. The numerical model is solved under non-steady conditions by examining the evolution of the flow during the stop and restart of the mixing system. An intermittent regime of the mixing system, which kept the active volume between 94% and 99%, is achieved. The results obtained can lead to the eventual energy optimization of the mixing system of the CSTR. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Calculation of Disease Dynamics in a Population of Households

    PubMed Central

    Ross, Joshua V.; House, Thomas; Keeling, Matt J.

    2010-01-01

    Early mathematical representations of infectious disease dynamics assumed a single, large, homogeneously mixing population. Over the past decade there has been growing interest in models consisting of multiple smaller subpopulations (households, workplaces, schools, communities), with the natural assumption of strong homogeneous mixing within each subpopulation, and weaker transmission between subpopulations. Here we consider a model of SIRS (susceptible-infectious-recovered-susceptible) infection dynamics in a very large (assumed infinite) population of households, with the simplifying assumption that each household is of the same size (although all methods may be extended to a population with a heterogeneous distribution of household sizes). For this households model we present efficient methods for studying several quantities of epidemiological interest: (i) the threshold for invasion; (ii) the early growth rate; (iii) the household offspring distribution; (iv) the endemic prevalence of infection; and (v) the transient dynamics of the process. We utilize these methods to explore a wide region of parameter space appropriate for human infectious diseases. We then extend these results to consider the effects of more realistic gamma-distributed infectious periods. We discuss how all these results differ from standard homogeneous-mixing models and assess the implications for the invasion, transmission and persistence of infection. The computational efficiency of the methodology presented here will hopefully aid in the parameterisation of structured models and in the evaluation of appropriate responses for future disease outbreaks. PMID:20305791

  4. High yield of recombinant human Apolipoprotein A-I expressed in Pichia pastoris by using mixed-mode chromatography.

    PubMed

    Narasimhan Janakiraman, Vignesh; Noubhani, Abdelmajid; Venkataraman, Krishnan; Vijayalakshmi, Mookambeswaran; Santarelli, Xavier

    2016-01-01

    A vast majority of the cardioprotective properties exhibited by High-Density Lipoprotein (HDL) is mediated by its major protein component Apolipoprotein A-I (ApoA1). In order to develop a simplified bioprocess for producing recombinant human Apolipoprotein A-I (rhApoA1) in its near-native form, rhApoA1was expressed without the use of an affinity tag in view of its potential therapeutic applications. Expressed in Pichia pastoris at expression levels of 58.2 mg ApoA1 per litre of culture in a reproducible manner, the target protein was purified by mixed-mode chromatography using Capto™ MMC ligand with a purity and recovery of 84% and 68%, respectively. ApoA1 purification was scaled up to Mixed-mode Expanded Bed Adsorption chromatography to establish an 'on-line' process for the efficient capture of rhApoA1 directly from the P. pastoris expression broth. A polishing step using anion exchange chromatography enabled the recovery of ApoA1 up to 96% purity. Purified ApoA1 was identified and verified by RPLC-ESI-Q-TOF mass spectrometry. This two-step process would reduce processing times and therefore costs in comparison to the twelve-step procedure currently used for recovering rhApoA1 from P. pastoris. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Sensitivity and diagnosticity of NASA-TLX and simplified SWAT to assess the mental workload associated with operating an agricultural sprayer.

    PubMed

    Dey, Asit; Mann, Danny D

    2010-07-01

    The objectives of the present study were: a) to investigate three continuous variants of the NASA-Task Load Index (TLX) (standard NASA (CNASA), average NASA (C1NASA) and principal component NASA (PCNASA)) and five different variants of the simplified subjective workload assessment technique (SSWAT) (continuous standard SSWAT (CSSWAT), continuous average SSWAT (C1SSWAT), continuous principal component SSWAT (PCSSWAT), discrete event-based SSWAT (D1SSWAT) and discrete standard SSWAT (DSSWAT)) in terms of their sensitivity and diagnosticity to assess the mental workload associated with agricultural spraying; b) to compare and select the best variants of NASA-TLX and SSWAT for future mental workload research in the agricultural domain. A total of 16 male university students (mean 30.4 +/- 12.5 years) participated in this study. All the participants were trained to drive an agricultural spraying simulator. Sensitivity was assessed by the ability of the scales to report the maximum change in workload ratings due to the change in illumination and difficulty levels. In addition, the factor loading method was used to quantify sensitivity. The diagnosticity was assessed by the ability of the scale to diagnose the change in task levels from single to dual. Among all the variants of NASA-TLX and SSWAT, PCNASA and discrete variants of SSWAT showed the highest sensitivity and diagnosticity. Moreover, among all the variants of NASA and SSWAT, the discrete variants of SSWAT showed the highest sensitivity and diagnosticity but also high between-subject variability. The continuous variants of both scales had relatively low sensitivity and diagnosticity and also low between-subject variability. Hence, when selecting a scale for future mental workload research in the agricultural domain, a researcher should decide what to compromise: 1) between-subject variability or 2) sensitivity and diagnosticity. STATEMENT OF RELEVANCE: The use of subjective workload scales is very popular in mental workload research. The present study investigated the different variants of two popular workload rating scales (i.e. NASA-TLX and SSWAT) in terms of their sensitivity and diagnositicity and selected the best variants of each scale for future mental workload research.

  6. [Evaluation of a new medium, eggplant (Solanum melongena) agar as a screening medium for Cryptococcus neoformans in environmental samples].

    PubMed

    Sengul, Mustafa; Ergin, Cağrı; Kartal, Tuğba

    2014-04-01

    Cryptococcus neofomans is an encapsulated yeast-like fungus that causes life-threatening infections, especially in immunosuppresive patients. C.neoformans infection is believed to be acquired via inhalation of aerosolized particles from the environment. Avian guano, decaying tree hollows and soil are the related known environmental niches. Brown pigmented yeast growth from the precursors in growth media is an important step for the identification and isolation of C.neoformans. Seeds of plants in nature are preferred owing to easy accessibility and low costs for the preparation of such media. Guizotia abysinicca (Niger seed) as Staib agar, Helianthus annus (Sunflower) as Pal's medium, Brassica nigra (Mustard) agar, tobacco agar, Mucuna pruriens (Velvet bean) seed agar, Perilla frutescens (Beefsteak plant) seed agar, Rubus fruticosus (Blackberry) agar and ground red hot pepper agar are pigment-based selective media for the differentiation of C.neoformans. The aim of this study was to observe the pigment production of C.neoformans in a new medium based on eggplant (Solanum melongena) and also to compare its performance with the simplified Staib, Pal's and tobacco agar for isolation from the environment. Three different eggplant-based medium (S.melongena Melanzaza viserba, S.melongena Pinstripe F1 and S.ovigerum Ivory F1) were included in the study. Pigment-forming eggplant medium, simplified Staib agar, Pal's agar and tobacco agar were used for the cultivation of the environmental swabbed samples from 19 Eucalyptus camaldulensis trunk hollows in continuous colonization region. While pigment formation were observed with S.melongena Melanzaza viserba and S.melongena Pinstripe F1 containing media, S.ovigerum Ivory F1 medium was found to be non-reactive. In colonization area (Gökova-Akyaka, Turkey), 11 (57.9%) out of 19 E.camaldulensis samples were positive with simplified Staib agar, Pal's agar and eggplant agar while 10 (52.6%) of them are positive with tobacco agar. C.neoformans colony forming unit (cfu) per plate were found as 51, 57 and 48 (median values) on simplified Staib agar, Pal's agar and eggplant agar, respectively, while tobacco agar has lower performance with 33 cfu/petri. No statistically significant difference were found between simplified Staib agar, Pal's agar and eggplant agar's performances for C.neoformans isolations from the nature (p=0.71). In conclusion, easily prepared eggplant agar is as functional as widely used media such as simplified Staib agar and Pal's agar for the isolation of C.neoformans from the natural environment.

  7. Improvement of two-way continuous-variable quantum key distribution with virtual photon subtraction

    NASA Astrophysics Data System (ADS)

    Zhao, Yijia; Zhang, Yichen; Li, Zhengyu; Yu, Song; Guo, Hong

    2017-08-01

    We propose a method to improve the performance of two-way continuous-variable quantum key distribution protocol by virtual photon subtraction. The virtual photon subtraction implemented via non-Gaussian post-selection not only enhances the entanglement of two-mode squeezed vacuum state but also has advantages in simplifying physical operation and promoting efficiency. In two-way protocol, virtual photon subtraction could be applied on two sources independently. Numerical simulations show that the optimal performance of renovated two-way protocol is obtained with photon subtraction only used by Alice. The transmission distance and tolerable excess noise are improved by using the virtual photon subtraction with appropriate parameters. Moreover, the tolerable excess noise maintains a high value with the increase in distance so that the robustness of two-way continuous-variable quantum key distribution system is significantly improved, especially at long transmission distance.

  8. Some properties of correlations of quantum lattice systems in thermal equilibrium

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fröhlich, Jürg, E-mail: juerg@phys.ethz.ch; Ueltschi, Daniel, E-mail: daniel@ueltschi.org

    Simple proofs of uniqueness of the thermodynamic limit of KMS states and of the decay of equilibrium correlations are presented for a large class of quantum lattice systems at high temperatures. New quantum correlation inequalities for general Heisenberg models are described. Finally, a simplified derivation of a general result on power-law decay of correlations in 2D quantum lattice systems with continuous symmetries is given, extending results of McBryan and Spencer for the 2D classical XY model.

  9. Simplified Resiliency Analysis of U.S. Army TOE (Table of Organization and Equipment) Units

    DTIC Science & Technology

    1988-03-01

    leadership , fire support, and comnunications assets are all key factors in determining a military unit’s ability to continue its mission. [Ref 5] A...significantly related to combat effectiveness. The perception of the soldier’s possibility of’ survival, competent leadership , and the soldier’s belief that what...good leadership , high morale and esprit de corps. The second may be ineffective due to the lack of one or all of these same qualities. The second

  10. Form and Function of Linguistic Elements. Formal Systems for Representing Changing Situations. Dynamic Information Systems: Notes on some systems of grammar and interpretation

    DTIC Science & Technology

    2009-02-20

    Chomsky (1957) and continued into the frameworks from around Chomsky’s Aspects (1965). The main thrust was to move from grammars centered on covering...Miminalist Program Grammars Work by Chomsky , starting around 1995 ( Chomsky 1995) represents a move toward radically simplified systems. A number...particular theories can be formulated as choices within such a general scheme or metatheory. 14 We take Richard Montague’s Universal Grammar

  11. REPRESENTATIONS OF WEAK AND STRONG INTEGRALS IN BANACH SPACES

    PubMed Central

    Brooks, James K.

    1969-01-01

    We establish a representation of the Gelfand-Pettis (weak) integral in terms of unconditionally convergent series. Moreover, absolute convergence of the series is a necessary and sufficient condition in order that the weak integral coincide with the Bochner integral. Two applications of the representation are given. The first is a simplified proof of the countable additivity and absolute continuity of the indefinite weak integral. The second application is to probability theory; we characterize the conditional expectation of a weakly integrable function. PMID:16591755

  12. BI-RADS update.

    PubMed

    Mercado, Cecilia L

    2014-05-01

    The updated American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) has been newly released. This article summarizes the changes and updates that have been made to BI-RADS. The goal of the revised edition continues to be the same: to improve clarification in image interpretation, maintain reporting standardization, and simplify the monitoring of outcomes. The new BI-RADS also introduces new terminology to provide a more universal lexicon across all 3 imaging modalities. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. Simplifying sun safety: a guide to the new FDA sunscreen monograph.

    PubMed

    Bronfenbrener, Roman

    2014-04-01

    Dermatologists are instrumental in educating their patients about safe sun practices. As residents, we should begin to instill this teaching point into our daily patient encounters. The new US Food and Drug Administration sunscreen guidelines, instituted fully in December 2012, help consumers make more educated decisions about sunscreens they purchase but also introduce new classifications and claims with which dermatologists should be intimately familiar. This article aims to concisely summarize the revisions as well as any continued controversies with the guidelines.

  14. Jet mixing in low gravity - Results of the Tank Pressure Control Experiment

    NASA Technical Reports Server (NTRS)

    Bentz, M. D.; Meserole, J. S.; Knoll, R. H.

    1992-01-01

    The Tank Pressure Control Experiment (TPCE) is discussed with attention given to the results for controlling storage-tank pressures by forced-convective mixing in microgravitational environments. The fluid dynamics of cryogenic fluids in space is simulated with freon-113 during axial-jet-induced mixing. The experimental flow-pattern data are found to confirm previous data as well as existing mixing correlations. Thermal nonuniformities and tank pressure can be reduced by employing low-energy mixing jets which are useful for enhancing heat/mass transfer between phases. It is found that space cryogenic systems based on the principle of active mixing can be more reliable and predictable than other methods, and continuous or periodic mixing can be accomplished with only minor energy addition to the fluid.

  15. Lorentz force effect on mixed convection micropolar flow in a vertical conduit

    NASA Astrophysics Data System (ADS)

    Abdel-wahed, Mohamed S.

    2017-05-01

    The present work provides a simulation of control and filtration process of hydromagnetic blood flow with Hall current under the effect of heat source or sink through a vertical conduit (pipe). This work meets other engineering applications, such as nuclear reactors cooled during emergency shutdown, geophysical transport in electrically conducting and heat exchangers at low velocity conditions. The problem is modeled by a system of partial differential equations taking the effect of viscous dissipation, and these equations are simplified and solved analytically as a series solution using the Differential Transformation Method (DTM). The velocities and temperature profiles of the flow are plotted and discussed. Moreover, the conduit wall shear stress and heat flux are deduced and explained.

  16. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.

    PubMed

    De Savi, Chris; Pape, Andrew; Sawyer, Yvonne; Milne, David; Davies, Chris; Cumming, John G; Ting, Attilla; Lamont, Scott; Smith, Peter D; Tart, Jonathon; Page, Ken; Moore, Peter

    2011-06-01

    A new achiral class of N-hydroxyformamide inhibitor of both ADAM-TS4 and ADAM-TS5, 2 has been discovered through modification of the complex P1 group present in historical inhibitors 1. This structural change improved the DMPK properties and greatly simplified the synthesis whilst maintaining excellent cross-MMP selectivity profiles. Investigation of structure-activity and structure-property relationships in the P1 group resulted in both ADAM-TS4 selective and mixed ADAM-TS4/5 inhibitors. This led to the identification of a pre-clinical candidate with excellent bioavailability across three species and predicting once daily dosing kinetics. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Self-rated health: small area large area comparisons amongst older adults at the state, district and sub-district level in India.

    PubMed

    Hirve, Siddhivinayak; Vounatsou, Penelope; Juvekar, Sanjay; Blomstedt, Yulia; Wall, Stig; Chatterji, Somnath; Ng, Nawi

    2014-03-01

    We compared prevalence estimates of self-rated health (SRH) derived indirectly using four different small area estimation methods for the Vadu (small) area from the national Study on Global AGEing (SAGE) survey with estimates derived directly from the Vadu SAGE survey. The indirect synthetic estimate for Vadu was 24% whereas the model based estimates were 45.6% and 45.7% with smaller prediction errors and comparable to the direct survey estimate of 50%. The model based techniques were better suited to estimate the prevalence of SRH than the indirect synthetic method. We conclude that a simplified mixed effects regression model can produce valid small area estimates of SRH. © 2013 Published by Elsevier Ltd.

  18. Verification of Orthogrid Finite Element Modeling Techniques

    NASA Technical Reports Server (NTRS)

    Steeve, B. E.

    1996-01-01

    The stress analysis of orthogrid structures, specifically with I-beam sections, is regularly performed using finite elements. Various modeling techniques are often used to simplify the modeling process but still adequately capture the actual hardware behavior. The accuracy of such 'Oshort cutso' is sometimes in question. This report compares three modeling techniques to actual test results from a loaded orthogrid panel. The finite element models include a beam, shell, and mixed beam and shell element model. Results show that the shell element model performs the best, but that the simpler beam and beam and shell element models provide reasonable to conservative results for a stress analysis. When deflection and stiffness is critical, it is important to capture the effect of the orthogrid nodes in the model.

  19. Facile MALDI-MS analysis of neutral glycans in NaOH-doped matrixes: microwave-assisted deglycosylation and one-step purification with diamond nanoparticles.

    PubMed

    Tzeng, Yan-Kai; Chang, Cheng-Chun; Huang, Chien-Ning; Wu, Chih-Che; Han, Chau-Chung; Chang, Huan-Cheng

    2008-09-01

    A streamlined protocol has been developed to accelerate, simplify, and enhance matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) of neutral underivatized glycans released from glycoproteins. It involved microwave-assisted enzymatic digestion and release of glycans, followed by rapid removal of proteins and peptides with carboxylated/oxidized diamond nanoparticles, and finally treating the analytes with NaOH before mixing them with acidic matrix (such as 2,5-dihydroxybenzoic acid) to suppress the formation of both peptide and potassiated oligosaccharide ions in MS analysis. The advantages of this protocol were demonstrated with MALDI-TOF-MS of N-linked glycans released from ovalbumin and ribonuclease B.

  20. Thermochemical generation of hydrogen and carbon dioxide

    NASA Technical Reports Server (NTRS)

    Lawson, Daniel D. (Inventor); England, Christopher (Inventor)

    1984-01-01

    Mixing of carbon in the form of high sulfur coal with sulfuric acid reduces the temperature of sulfuric acid decomposition from 830.degree. C. to between 300.degree. C. and 400.degree. C. The low temperature sulfuric acid decomposition is particularly useful in thermal chemical cycles for splitting water to produce hydrogen. Carbon dioxide is produced as a commercially desirable byproduct. Lowering of the temperature for the sulfuric acid decomposition or oxygen release step simplifies equipment requirements, lowers thermal energy input and reduces corrosion problems presented by sulfuric acid at conventional cracking temperatures. Use of high sulfur coal as the source of carbon for the sulfuric acid decomposition provides an environmentally safe and energy efficient utilization of this normally polluting fuel.

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