DOE Office of Scientific and Technical Information (OSTI.GOV)

Crowder, Stephen V.

This document outlines a statistical framework for establishing a shelf-life program for components whose performance is measured by the value of a continuous variable such as voltage or function time. The approach applies to both single measurement devices and repeated measurement devices, although additional process control charts may be useful in the case of repeated measurements. The approach is to choose a sample size that protects the margin associated with a particular variable over the life of the component. Deviations from expected performance of the measured variable are detected prior to the complete loss of margin. This ensures the reliabilitymore » of the component over its lifetime.« less

A comparison between three different pit and fissure sealants with regard to marginal integrity.

PubMed

Fernandes, Kristlee Sabrin; Chalakkal, Paul; de Ataide, Ida de Noronha; Pavaskar, Rajdeep; Fernandes, Precylia Philo; Soni, Harleen

2012-04-01

THE AIM OF THIS STUDY IS TO COMPARE THE OCCURRENCE OF ENAMEL FRACTURES, SEALANT FRACTURES AND MARGINAL FISSURES AFTER PLACEMENT OF THREE SEALANTS: Helioseal F, Conseal F and Clinpro. Thirty individuals between 13 and 15 years of age, diagnosed with pit and fissure caries by visual and DIAGNOdent examination, were chosen for sealant placement on their mandibular molars. The sealants were placed at random, after which, impressions were made with polyvinyl siloxane and casts were fabricated. Dies were prepared, each of which were sputter coated with gold in order to be examined under a scanning electron microscope. The following morphologies were analyzed from dies from each of the sealant groups: Continuous margins, sealant fractures, marginal fissures and enamel fractures. After six months, they were recalled for impression making. Dies were prepared and microscopically analyzed as mentioned. Based on the time of evaluation, there were two groups: Initial group (soon after placement) and final group (after six months). Statistical analysis was done using the paired 't' test and One-way analysis of variance (ANOVA). Clinpro had the greatest fracture resistance, followed by Conseal F and Helioseal F. The occurrence of marginal fissure was found to be least with Clinpro.

41 CFR 102-80.115 - Is there more than one option for establishing that an equivalent level of safety exists?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., complete sprinkler protection can be expected to prevent flashover in the room of fire origin, limit fire... the times required for egress. If a combination of fire protection systems provides a margin of safety... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

41 CFR 102-80.115 - Is there more than one option for establishing that an equivalent level of safety exists?

Code of Federal Regulations, 2012 CFR

2012-01-01

..., complete sprinkler protection can be expected to prevent flashover in the room of fire origin, limit fire... the times required for egress. If a combination of fire protection systems provides a margin of safety... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

41 CFR 102-80.115 - Is there more than one option for establishing that an equivalent level of safety exists?

Code of Federal Regulations, 2014 CFR

2014-01-01

..., complete sprinkler protection can be expected to prevent flashover in the room of fire origin, limit fire... the times required for egress. If a combination of fire protection systems provides a margin of safety... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

41 CFR 102-80.115 - Is there more than one option for establishing that an equivalent level of safety exists?

Code of Federal Regulations, 2011 CFR

2011-01-01

..., complete sprinkler protection can be expected to prevent flashover in the room of fire origin, limit fire... the times required for egress. If a combination of fire protection systems provides a margin of safety... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL...

Applied Time Domain Stability Margin Assessment for Nonlinear Time-Varying Systems

NASA Technical Reports Server (NTRS)

Kiefer, J. M.; Johnson, M. D.; Wall, J. H.; Dominguez, A.

2016-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation. This technique was implemented by using the Stability Aerospace Vehicle Analysis Tool (SAVANT) computer simulation to evaluate the stability of the SLS system with the Adaptive Augmenting Control (AAC) active and inactive along its ascent trajectory. The gains for which the vehicle maintains apparent time-domain stability defines the gain margins, and the time delay similarly defines the phase margin. This method of extracting the control stability margins from the time-domain simulation is relatively straightforward and the resultant margins can be compared to the linearized system results. The sections herein describe the techniques employed to extract the time-domain margins, compare the results between these nonlinear and the linear methods, and provide explanations for observed discrepancies. The SLS ascent trajectory was simulated with SAVANT and the classical linear stability margins were evaluated at one second intervals. The linear analysis was performed with the AAC algorithm disabled to attain baseline stability margins. At each time point, the system was linearized about the current operating point using Simulink's built-in solver. Each linearized system in time was evaluated for its rigid-body gain margin (high frequency gain margin), rigid-body phase margin, and aero gain margin (low frequency gain margin) for each control axis. Using the stability margins derived from the baseline linearization approach, the time domain derived stability margins were determined by executing time domain simulations in which axis-specific incremental gain and phase adjustments were made to the nominal system about the expected neutral stability point at specific flight times. The baseline stability margin time histories were used to shift the system gain to various values around the zero margin point such that a precise amount of expected gain margin was maintained throughout flight. When assessing the gain margins, the gain was applied starting at the time point under consideration, thereafter following the variation in the margin found in the linear analysis. When assessing the rigid-body phase margin, a constant time delay was applied to the system starting at the time point under consideration. If the baseline stability margins were correctly determined via the linear analysis, the time domain simulation results should contain unstable behavior at certain gain and phase values. Examples will be shown from repeated simulations with variable added gain and phase lag. Faithfulness of margins calculated from the linear analysis to the nonlinear system will be demonstrated.

Effective Thermodynamics for a Marginal Observer

NASA Astrophysics Data System (ADS)

Polettini, Matteo; Esposito, Massimiliano

2017-12-01

Thermodynamics is usually formulated on the presumption that the observer has complete information about the system he or she deals with: no parasitic current, exact evaluation of the forces that drive the system. For example, the acclaimed fluctuation relation (FR), relating the probability of time-forward and time-reversed trajectories, assumes that the measurable transitions suffice to characterize the process as Markovian (in our case, a continuous-time jump process). However, most often the observer only measures a marginal current. We show that he or she will nonetheless produce an effective description that does not dispense with the fundamentals of thermodynamics, including the FR and the 2nd law. Our results stand on the mathematical construction of a hidden time reversal of the dynamics, and on the physical requirement that the observed current only accounts for a single transition in the configuration space of the system. We employ a simple abstract example to illustrate our results and to discuss the feasibility of generalizations.

Role of tumour-free margin distance for loco-regional control in vulvar cancer-a subset analysis of the Arbeitsgemeinschaft Gynäkologische Onkologie CaRE-1 multicenter study.

PubMed

Woelber, Linn; Griebel, Lis-Femke; Eulenburg, Christine; Sehouli, Jalid; Jueckstock, Julia; Hilpert, Felix; de Gregorio, Nikolaus; Hasenburg, Annette; Ignatov, Atanas; Hillemanns, Peter; Fuerst, Sophie; Strauss, Hans-Georg; Baumann, Klaus H; Thiel, Falk C; Mustea, Alexander; Meier, Werner; Harter, Philipp; Wimberger, Pauline; Hanker, Lars Christian; Schmalfeldt, Barbara; Canzler, Ulrich; Fehm, Tanja; Luyten, Alexander; Hellriegel, Martin; Kosse, Jens; Heiss, Christoph; Hantschmann, Peer; Mallmann, Peter; Tanner, Berno; Pfisterer, Jacobus; Richter, Barbara; Neuser, Petra; Mahner, Sven

2016-12-01

A tumour-free pathological resection margin of ≥8 mm is considered state-of-the-art. Available evidence is based on heterogeneous cohorts. This study was designed to clarify the relevance of the resection margin for loco-regional control in vulvar cancer. AGO-CaRE-1 is a large retrospective study. Patients (n = 1618) with vulvar cancer ≥ FIGO stage IB treated at 29 German gynecologic-cancer-centres 1998-2008 were included. This subgroup analysis focuses on solely surgically treated node-negative patients with complete tumour resection (n = 289). Of the 289 analysed patients, 141 (48.8%) had pT1b, 140 (48.4%) pT2 and 8 (2.8%) pT3 tumours. One hundred twenty-five (43.3%) underwent complete vulvectomy, 127 (43.9%) partial vulvectomy and 37 (12.8%) radical local excision. The median minimal resection margin was 5 mm (1 mm-33 mm); all patients received groin staging, in 86.5% with full dissection. Median follow-up was 35.1 months. 46 (15.9%) patients developed recurrence, thereof 34 (11.8%) at the vulva, after a median of 18.3 months. Vulvar recurrence rates were 12.6% in patients with a margin <8 mm and 10.2% in patients with a margin ≥8 mm. When analysed as a continuous variable, the margin distance had no statistically significant impact on local recurrence (HR per mm increase: 0.930, 95% CI: 0.849-1.020; p = 0.125). Multivariate analyses did also not reveal a significant association between the margin and local recurrence neither when analysed as continuous variable nor categorically based on the 8 mm cutoff. Results were consistent when looking at disease-free-survival and time-to-recurrence at any site (HR per mm increase: 0.949, 95% CI: 0.864-1.041; p = 0.267). The need for a minimal margin of 8 mm could not be confirmed in the large and homogeneous node-negative cohort of the AGO-CaRE database. Copyright © 2016 Elsevier Ltd. All rights reserved.

Dynamic frailty models based on compound birth-death processes.

PubMed

Putter, Hein; van Houwelingen, Hans C

2015-07-01

Frailty models are used in survival analysis to model unobserved heterogeneity. They accommodate such heterogeneity by the inclusion of a random term, the frailty, which is assumed to multiply the hazard of a subject (individual frailty) or the hazards of all subjects in a cluster (shared frailty). Typically, the frailty term is assumed to be constant over time. This is a restrictive assumption and extensions to allow for time-varying or dynamic frailties are of interest. In this paper, we extend the auto-correlated frailty models of Henderson and Shimakura and of Fiocco, Putter and van Houwelingen, developed for longitudinal count data and discrete survival data, to continuous survival data. We present a rigorous construction of the frailty processes in continuous time based on compound birth-death processes. When the frailty processes are used as mixtures in models for survival data, we derive the marginal hazards and survival functions and the marginal bivariate survival functions and cross-ratio function. We derive distributional properties of the processes, conditional on observed data, and show how to obtain the maximum likelihood estimators of the parameters of the model using a (stochastic) expectation-maximization algorithm. The methods are applied to a publicly available data set. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Non-inferiority tests for anti-infective drugs using control group quantiles.

PubMed

Fay, Michael P; Follmann, Dean A

2016-12-01

In testing for non-inferiority of anti-infective drugs, the primary endpoint is often the difference in the proportion of failures between the test and control group at a landmark time. The landmark time is chosen to approximately correspond to the qth historic quantile of the control group, and the non-inferiority margin is selected to be reasonable for the target level q. For designing these studies, a troubling issue is that the landmark time must be pre-specified, but there is no guarantee that the proportion of control failures at the landmark time will be close to the target level q. If the landmark time is far from the target control quantile, then the pre-specified non-inferiority margin may not longer be reasonable. Exact variable margin tests have been developed by Röhmel and Kieser to address this problem, but these tests can have poor power if the observed control failure rate at the landmark time is far from its historic value. We develop a new variable margin non-inferiority test where we continue sampling until a pre-specified proportion of failures, q, have occurred in the control group, where q is the target quantile level. The test does not require any assumptions on the failure time distributions, and hence, no knowledge of the true [Formula: see text] control quantile for the study is needed. Our new test is exact and has power comparable to (or greater than) its competitors when the true control quantile from the study equals (or differs moderately from) its historic value. Our nivm R package performs the test and gives confidence intervals on the difference in failure rates at the true target control quantile. The tests can be applied to time to cure or other numeric variables as well. A substantial proportion of new anti-infective drugs being developed use non-inferiority tests in their development, and typically, a pre-specified landmark time and its associated difference margin are set at the design stage to match a specific target control quantile. If through changing standard of care or selection of a different population the target quantile for the control group changes from its historic value, then the appropriateness of the pre-specified margin at the landmark time may be questionable. Our proposed test avoids this problem by sampling until a pre-specified proportion of the controls have failed. © The Author(s) 2016.

Continuous monitoring and intrafraction target position correction during treatment improves target coverage for patients undergoing SBRT prostate therapy.

PubMed

Lovelock, D Michael; Messineo, Alessandra P; Cox, Brett W; Kollmeier, Marisa A; Zelefsky, Michael J

2015-03-01

To compare the potential benefits of continuous monitoring of prostate position and intervention (CMI) using 2-mm displacement thresholds during stereotactic body radiation therapy (SBRT) treatment to those of a conventional image-guided procedure involving single localization prior to treatment. Eighty-nine patients accrued to a prostate SBRT dose escalation protocol were implanted with radiofrequency transponder beacons. The planning target volume (PTV) margin was 5 mm in all directions, except for 3 mm in the posterior direction. The prostate was kept within 2 mm of its planned position by the therapists halting dose delivery and, if necessary, correcting the couch position. We computed the number, type, and time required for interventions and where the prostate would have been during dose delivery had there been, instead, a single image-guided setup procedure prior to each treatment. Distributions of prostate displacements were computed as a function of time. After the initial setup, 1.7 interventions per fraction were required, with a concomitant increase in time for dose delivery of approximately 65 seconds. Small systematic drifts in prostate position in the posterior and inferior directions were observed in the study patients. Without CMI, intrafractional motion would have resulted in approximately 10% of patients having a delivered dose that did not meet our clinical coverage requirement, that is, a PTV D95 of >90%. The posterior PTV margin required for 95% of the dose to be delivered with the target positioned within the PTV was computed as a function of time. The margin necessary was found to increase by 2 mm every 5 minutes, starting from the time of the imaging procedure. CMI using a tight 2-mm displacement threshold was not only feasible but was found to deliver superior PTV coverage compared with the conventional image-guided procedure in the SBRT setting. Copyright © 2015 Elsevier Inc. All rights reserved.

Continuous Monitoring and Intrafraction Target Position Correction During Treatment Improves Target Coverage for Patients Undergoing SBRT Prostate Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lovelock, D. Michael, E-mail: lovelocm@mskcc.org; Messineo, Alessandra P.; Cox, Brett W.

2015-03-01

Purpose: To compare the potential benefits of continuous monitoring of prostate position and intervention (CMI) using 2-mm displacement thresholds during stereotactic body radiation therapy (SBRT) treatment to those of a conventional image-guided procedure involving single localization prior to treatment. Methods and Materials: Eighty-nine patients accrued to a prostate SBRT dose escalation protocol were implanted with radiofrequency transponder beacons. The planning target volume (PTV) margin was 5 mm in all directions, except for 3 mm in the posterior direction. The prostate was kept within 2 mm of its planned position by the therapists halting dose delivery and, if necessary, correcting themore » couch position. We computed the number, type, and time required for interventions and where the prostate would have been during dose delivery had there been, instead, a single image-guided setup procedure prior to each treatment. Distributions of prostate displacements were computed as a function of time. Results: After the initial setup, 1.7 interventions per fraction were required, with a concomitant increase in time for dose delivery of approximately 65 seconds. Small systematic drifts in prostate position in the posterior and inferior directions were observed in the study patients. Without CMI, intrafractional motion would have resulted in approximately 10% of patients having a delivered dose that did not meet our clinical coverage requirement, that is, a PTV D95 of >90%. The posterior PTV margin required for 95% of the dose to be delivered with the target positioned within the PTV was computed as a function of time. The margin necessary was found to increase by 2 mm every 5 minutes, starting from the time of the imaging procedure. Conclusions: CMI using a tight 2-mm displacement threshold was not only feasible but was found to deliver superior PTV coverage compared with the conventional image-guided procedure in the SBRT setting.« less

Holistic Approach Offers Potential to Quantify Mass Fluxes Across Continental Margins

NASA Astrophysics Data System (ADS)

Kuehl, Steven; Carter, Lionel; Gomez, Basil; Trustrum, Noel

Most humans live on and utilize the continental margin, the surface of which changes continually in response to environmental perturbations such as weather, climate change, tectonism, earthquakes, volcanism, sea level, and human settlement and land use. Part of the margin is above sea level and the rest is submarine, but these land and seascape components are contiguous, and material transport from source to sink occurs as a seamless cascade. The margin responds to environmental perturbations by changing the nature and magnitude of a variety of important functions, including the distribution of soil formation and erosion; biogeochemical functioning (especially the storage and release of water, limiting nutrients and contaminants); and the form and behavior of geomorphic components from hill slopes and floodplains through the coastal zone to the continental rise. While some areas of the margin are eroding-for example, hill slopes-others accumulate sediment, such as tectonic basins and continental slope and rise. These areas record the history of surface changes. A major goal of the Earth science community is to provide quantitative explanations and predictions of the effects of environmental perturbations on surface changes and preserved sedimentary strata of continental margins. In past decades, margins have been investigated piecemeal by researchers who have tended to focus on a particular segment from one disciplinary perspective while eschewing the broader perspective of the margin as an interconnected whole. Recognizing this shortcoming, the U.S. National Science Foundation (NSF) has initiated the MARGINS Source-to-Sink (S2S) program, which, for the first time, will attempt to understand the functioning of entire margin systems through dedicated observational and community modeling studies. Following input from the Earth science community, the Waipaoa Sedimentary System (WSS) of the North Island, New Zealand, was chosen as one of the focus sites for possible study (see MARGINS Source-to-Sink science plan for selection criteria and rationale: http://www.ldeo.columbia.edu/margins/S2S/S2Ssciplan02.html).

Post-breakup faulting of the outer Vøring Margin

NASA Astrophysics Data System (ADS)

Planke, S.; Millett, J.; Jerram, D. A.; Maharjan, D.; Hafeez, A.; Abdelmalak, M. M.; Zastrozhnov, D.; Faleide, J. I.

2017-12-01

Tectonic activity on passive margins may continue for a long time after the main phase of continental breakup. On the southern Vøring Margin, offshore Norway, new high-quality 3D seismic data reveal the presence of extensive normal faults offsetting the Top basalt horizon, along with overlying lower Eocene age sediments. We have completed a detailed seismic interpretation of the new data using a combination of conventional seismic horizon interpretation and igneous seismic geomorphological techniques. The seismic data have been tied to scientific and industry wells to constrain the age of the interpreted horizons and the age and duration of the faulting. The Top basalt horizon displays a dominantly subaerial lava field, on the Vøring Marginal High, with well-defined lava flow morphologies including inflated flow lobes and surface pressure ridges. The prominent kilometer-high Vøring Escarpment was developed when landward flowing lava met the ocean, developing an extensive foreset bedded hyaloclastite delta. Later, a pitted surface was developed in the west during lava emplacement in a wet environment during subsidence of the central rift valley. Earliest Eocene sediments were subsequently deposited on the marginal high. Well-defined northeast trending faults are imaged on the marginal high, cutting across the escarpment. Spacing of the faults is ca. 400-500 m, and offsets are typically of ca. 30-50 m, often defining graben structures. The faults further offset the overlying earliest Eocene sequences in a number of examples. Based on the well ties, faulting mainly took place 5-10 m.y. after continental breakup near the Paleocene-Eocene boundary. Our hypothesis is that the faulting is related to strain partitioning across the developing Vøring Transform Margin. Plate tectonic constraints show that there was an active continent-continent transform in this region also for 10-15 m.y. after breakup. The transform margin is a linear, northwest trending structure, with a well-developed transform marginal high, the Mimir High, along its central part. The transform margin extends into the southwestern segment of the Jan Mayen Fracture Zone to the northwest. We speculate that the ocean basin separating the Vøring Spur from the Vøring Marginal High was formed by a rift propagation event during the same time period.

46 CFR 171.015 - Location of margin line.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Location of margin line. 171.015 Section 171.015 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS General § 171.015 Location of margin line. (a) A vessel with a...

Tracking channel bed resiliency in forested mountain catchments using high temporal resolution channel bed movement

NASA Astrophysics Data System (ADS)

Conklin, M. H.; Martin, S.

2017-12-01

This study uses continuous-recording load cell pressure sensors in four, high-elevation (1500-1800 m), Sierra Nevada, headwater streams, to collect high temporal resolution, bedload-movement data for investigating the channel bed movement patterns within these streams for water years 2012-2014. Data show an annual pattern where channel bed material in the thalweg starts to build up in early fall, peaks around peak snow melt, and scours back to baseline levels during hydrograph drawdown and baseflow. This pattern is punctuated by disturbance and recovery of channel bed material associated with short-term, storm events. We propose conceptual model, linking sediment sources at the channel margins to patterns of channel bed fill and scour in the thalweg, based on this and earlier work showing in-stream sources for bedload material. The material in the thalweg represents a balance between sediment supply from the channel margins and sporadic, conveyor-belt-like, downstream transport in the thalweg. The conceptual model highlights not only the importance of production and transport rates but also that seasonal connectedness between the margins and thalweg is a key sediment control, determining both the accumulation rate of sediment stores at the margins, and the redistribution of sediment from margins to thalweg that "feeds" the conveyor-belt. Disturbance and recovery cycles are observed at multiple temporal scales, but long term, the channel beds are stable, suggesting the beds act as short-term storage for sediment, but are in equilibrium interannually. The feasibility of use for these sensors in forested mountain stream environments is tested. Despite a high failure rate (50%), load cell pressure sensors show potential for high-temporal-resolution bedload measurements, allowing for the collection of channel bed movement data to move beyond time-integrated change measurements - where many of the subtleties of bedload movement patterns may be missed - to continuous and/or real-time measurements. This type of high-temporal-resolution data provides insight into short term cycles of bedload movement in high gradient, forested, mountain streams.

Tracking channel bed resiliency in forested mountain catchments using high temporal resolution channel bed movement

NASA Astrophysics Data System (ADS)

Martin, Sarah E.; Conklin, Martha H.

2018-01-01

This study uses continuous-recording load cell pressure sensors in four, high-elevation (1500-1800 m), Sierra Nevada headwater streams to collect high-temporal-resolution, bedload-movement data for investigating the channel bed movement patterns within these streams for water years 2012-2014. Data show an annual pattern where channel bed material in the thalweg starts to build up in early fall, peaks around peak snow melt, and scours back to baseline levels during hydrograph drawdown and base flow. This pattern is punctuated by disturbance and recovery of channel bed material associated with short-term storm events. A conceptual model, linking sediment sources at the channel margins to patterns of channel bed fill and scour in the thalweg, is proposed building on the results of Martin et al. (2014). The material in the thalweg represents a balance between sediment supply from the channel margins and sporadic, conveyor-belt-like downstream transport in the thalweg. The conceptual model highlights not only the importance of production and transport rates but also that seasonal connectedness between the margins and thalweg is a key sediment control, determining the accumulation rate of sediment stores at the margins and the redistribution of sediment from margins to thalweg that feeds the conveyor belt. Disturbance and recovery cycles are observed at multiple temporal scales; but long term, the channel beds are stable, suggesting that the beds act as short-term storage for sediment but are in equilibrium interannually. The feasibility of use for these sensors in forested mountain stream environments is tested. Despite a high failure rate (50%), load cell pressure sensors show potential for high-temporal-resolution bedload measurements, allowing for the collection of channel bed movement data to move beyond time-integrated change measurements - where many of the subtleties of bedload movement patterns may be missed - to continuous and/or real-time measurements. This type of high-temporal-resolution data provides insight into short-term cycles of bedload movement in high gradient, forested mountain streams.

A theoretically consistent stochastic cascade for temporal disaggregation of intermittent rainfall

NASA Astrophysics Data System (ADS)

Lombardo, F.; Volpi, E.; Koutsoyiannis, D.; Serinaldi, F.

2017-06-01

Generating fine-scale time series of intermittent rainfall that are fully consistent with any given coarse-scale totals is a key and open issue in many hydrological problems. We propose a stationary disaggregation method that simulates rainfall time series with given dependence structure, wet/dry probability, and marginal distribution at a target finer (lower-level) time scale, preserving full consistency with variables at a parent coarser (higher-level) time scale. We account for the intermittent character of rainfall at fine time scales by merging a discrete stochastic representation of intermittency and a continuous one of rainfall depths. This approach yields a unique and parsimonious mathematical framework providing general analytical formulations of mean, variance, and autocorrelation function (ACF) for a mixed-type stochastic process in terms of mean, variance, and ACFs of both continuous and discrete components, respectively. To achieve the full consistency between variables at finer and coarser time scales in terms of marginal distribution and coarse-scale totals, the generated lower-level series are adjusted according to a procedure that does not affect the stochastic structure implied by the original model. To assess model performance, we study rainfall process as intermittent with both independent and dependent occurrences, where dependence is quantified by the probability that two consecutive time intervals are dry. In either case, we provide analytical formulations of main statistics of our mixed-type disaggregation model and show their clear accordance with Monte Carlo simulations. An application to rainfall time series from real world is shown as a proof of concept.

47 CFR 63.53 - Form.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) EXTENSION OF LINES, NEW... more than 35.6 cm (14 in) long with a left-hand margin of 4 cm (1.5 in). This requirement shall not... than 21.6 cm (8.5 in) wide and not more than 35.6 cm (14 in) long with a left-hand margin of 4 cm (1.5...

47 CFR 63.53 - Form.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) EXTENSION OF LINES, NEW... more than 35.6 cm (14 in) long with a left-hand margin of 4 cm (1.5 in). This requirement shall not... than 21.6 cm (8.5 in) wide and not more than 35.6 cm (14 in) long with a left-hand margin of 4 cm (1.5...

Turbine Engine Clearance Control Systems: Current Practices and Future Directions

NASA Astrophysics Data System (ADS)

Lattime, Scott B.; Steinetz, Bruce M.

2002-09-01

Improved blade tip sealing in the high pressure compressor (HPC) and high pressure turbine (HPT) can provide dramatic reductions in specific fuel consumption (SFC), time-on-wing, compressor stall margin, and engine efficiency as well as increased payload and mission range capabilities. Maintenance costs to overhaul large commercial gas turbine engines can easily exceed 1M. Engine removal from service is primarily due to spent exhaust gas temperature (EGT) margin caused mainly by the deterioration of HPT components. Increased blade tip clearance is a major factor in hot section component degradation. As engine designs continue to push the performance envelope with fewer parts and the market drives manufacturers to increase service life, the need for advanced sealing continues to grow. A review of aero gas turbine engine HPT performance degradation and the mechanisms that promote these losses are discussed. Benefits to the HPT due to improved clearance management are identified. Past and present sealing technologies are presented along with specifications for next generation engine clearance control systems.

Turbine Engine Clearance Control Systems: Current Practices and Future Directions

NASA Technical Reports Server (NTRS)

Lattime, Scott B.; Steinetz, Bruce M.

2002-01-01

Improved blade tip sealing in the high pressure compressor (HPC) and high pressure turbine (HPT) can provide dramatic reductions in specific fuel consumption (SFC), time-on-wing, compressor stall margin, and engine efficiency as well as increased payload and mission range capabilities. Maintenance costs to overhaul large commercial gas turbine engines can easily exceed $1M. Engine removal from service is primarily due to spent exhaust gas temperature (EGT) margin caused mainly by the deterioration of HPT components. Increased blade tip clearance is a major factor in hot section component degradation. As engine designs continue to push the performance envelope with fewer parts and the market drives manufacturers to increase service life, the need for advanced sealing continues to grow. A review of aero gas turbine engine HPT performance degradation and the mechanisms that promote these losses are discussed. Benefits to the HPT due to improved clearance management are identified. Past and present sealing technologies are presented along with specifications for next generation engine clearance control systems.

A Very Slow Recovery: The Annual Report on the Economic Status of the Profession, 2011-12

ERIC Educational Resources Information Center

Thornton, Saranna; Curtis, John W.

2012-01-01

This article presents the annual report on the economic status of the profession. Although the results of this year's survey of full-time faculty compensation are marginally better than they have been the last two years, 2011-12 represents the continuation of a historic low period for faculty salaries. The overall average salary for full-time…

Basins in ARC-continental collisions

USGS Publications Warehouse

Draut, Amy E.; Clift, Peter D.; Busby, Cathy; Azor, Antonio

2012-01-01

Arc-continent collisions occur commonly in the plate-tectonic cycle and result in rapidly formed and rapidly collapsing orogens, often spanning just 5-15 My. Growth of continental masses through arc-continent collision is widely thought to be a major process governing the structural and geochemical evolution of the continental crust over geologic time. Collisions of intra-oceanic arcs with passive continental margins (a situation in which the arc, on the upper plate, faces the continent) involve a substantially different geometry than collisions of intra-oceanic arcs with active continental margins (a situation requiring more than one convergence zone and in which the arc, on the lower plate, backs into the continent), with variable preservation potential for basins in each case. Substantial differences also occur between trench and forearc evolution in tectonically erosive versus tectonically accreting margins, both before and after collision. We examine the evolution of trenches, trench-slope basins, forearc basins, intra-arc basins, and backarc basins during arc-continent collision. The preservation potential of trench-slope basins is low; in collision they are rapidly uplifted and eroded, and at erosive margins they are progressively destroyed by subduction erosion. Post-collisional preservation of trench sediment and trench-slope basins is biased toward margins that were tectonically accreting for a substantial length of time before collision. Forearc basins in erosive margins are usually floored by strong lithosphere and may survive collision with a passive margin, sometimes continuing sedimentation throughout collision and orogeny. The low flexural rigidity of intra-arc basins makes them deep and, if preserved, potentially long records of arc and collisional tectonism. Backarc basins, in contrast, are typically subducted and their sediment either lost or preserved only as fragments in melange sequences. A substantial proportion of the sediment derived from collisional orogenesis ends up in the foreland basin that forms as a result of collision, and may be preserved largely undeformed. Compared to continent-continent collisional foreland basins, arc-continent collisional foreland basins are short-lived and may undergo partial inversion after collision as a new, active continental margin forms outboard of the collision zone and the orogen whose load forms the basin collapses in extension.

Factors That Influence Surgical Margin State in Patients Undergoing Cold Knife Conization - A Single Center Experience.

PubMed

Aluloski, Igor; Tanturovski, Mile; Petrusevska, Gordana; Jovanovic, Rubens; Kostadinova-Kunovska, Slavica

2017-12-01

To evaluate the factors that influence the surgical margin state in patients undergoing cold knife conization at the University Clinic of Gynecology and Obstetrics in Skopje, Republic of Macedonia Materials and methods: We have retrospectively analyzed the medical records of all patients that underwent a cold knife conization at our Clinic in 2015. We cross-referenced the surgical margin state with the histopathological diagnosis (LSIL, HSIL or micro-invasive/invasive cancer), menopausal status of the patients, number of pregnancies, surgeon experience, operating time and cone depth. The data was analyzed with the Chi square test, Fisher's exact test for categorical data and Student's T test for continuous data and univariate and multivariate logistical regressions were performed. A total of 246 medical records have neen analyzed, out of which 29 (11.79%) patients had LSIL, 194 (78.86%) had HSIL and 23 (9.34%) patients suffered micro-invasive/invasive cervical cancer. The surgical margins were positive in 78 (31.7%) of the patients. The average age of the patients was 41.13 and 35 (14.23%) of the patients were menopausal. The multivariate logistic regression identified preoperative forceps biopsy of micro-invasive SCC, HSIL or higher cone specimen histology and shorter cone depth as independent predictors of surgical margin involvement in patients undergoing cold knife conization. In the current study, we have found no association between the inherent characteristics of the patient and the surgeon and the surgical margin state after a CKC. The most important predictors for positive margins were the severity of the lesion and the cone depth.

Stigma Experiences in Marginalized People Living With HIV Seeking Health Services and Resources in Canada.

PubMed

Donnelly, Leeann R; Bailey, Lauren; Jessani, Abbas; Postnikoff, Jonathan; Kerston, Paul; Brondani, Mario

HIV stigma may prevent people from obtaining a timely diagnosis and engaging in life-saving care. It may also prevent those who are HIV infected from seeking health and education resources, particularly if they are from marginalized communities. We inductively explored the roots of stigma and its impact on health services and resource seeking as experienced by HIV-infected members of marginalized communities in Vancouver, British Columbia, Canada, using a community-based participatory research framework. Five peer-facilitated focus groups were conducted with 33 Aboriginal, Latino, Asian, and African participants. Thematic analysis of the experiences revealed four dominant themes: beginnings of stigma, tensions related to disclosure, experiences of service seeking, and beyond HIV stigma and discrimination. Persons living with HIV from Aboriginal and refugee communities continue to experience disproportionate rates of stigma and discrimination. Fear remains a prime obstacle influencing these groups' abilities and willingness to access care in various settings. Copyright © 2016 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.

On the initiation of subduction zones

NASA Astrophysics Data System (ADS)

Cloetingh, Sierd; Wortel, Rinus; Vlaar, N. J.

1989-03-01

Analysis of the relation between intraplate stress fields and lithospheric rheology leads to greater insight into the role that initiation of subduction plays in the tectonic evolution of the lithosphere. Numerical model studies show that if after a short evolution of a passive margin (time span a few tens of million years) subduction has not yet started, continued aging of the passive margin alone does not result in conditions more favorable for transformation into an active margin. Although much geological evidence is available in supporting the key role small ocean basins play in orogeny and ophiolite emplacement, evolutionary frameworks of the Wilson cycle usually are cast in terms of opening and closing of wide ocean basins. We propose a more limited role for large oceans in the Wilson cycle concept. In general, initiation of subduction at passive margins requires the action of external plate-tectonic forces, which will be most effective for young passive margins prestressed by thick sedimentary loads. It is not clear how major subduction zones (such as those presently ringing the Pacific Basin) form but it is unlikely they form merely by aging of oceanic lithosphere. Conditions likely to exist in very young oceanic regions are quite favorable for the development of subduction zones, which might explain the lack of preservation of back-arc basins and marginal seas. Plate reorganizations probably occur predominantly by the formation of new spreading ridges, because stress relaxation in the lithosphere takes place much more efficiently through this process than through the formation of new subduction zones.

Unintended consequences of expensive cancer therapeutics—the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: the John Conley Lecture.

PubMed

Fojo, Tito; Mailankody, Sham; Lo, Andrew

2014-12-01

Cancer is expected to continue as a major health and economic problem worldwide. Several factors are contributing to the increasing economic burden imposed by cancer, with the cost of cancer drugs an undeniably important variable. The use of expensive therapies with marginal benefits for their approved indications and for unproven indications is contributing to the rising cost of cancer care. We believe that expensive therapies are stifling progress by (1) encouraging enormous expenditures of time, money, and resources on marginal therapeutic indications and (2) promoting a me-too mentality that is stifling innovation and creativity. The modest gains of Food and Drug Administration-approved therapies and the limited progress against major cancers is evidence of a lowering of the efficacy bar that, together with high drug prices, has inadvertently incentivized the pursuit of marginal outcomes and a me-too mentality evidenced by the duplication of effort and redundant pharmaceutical pipelines. We discuss the economic realities that are driving this process and provide suggestions for radical changes to reengineer our collective cancer ecosystem to achieve better outcomes for society.

Detection of high-energy gamma-ray emission during the X-ray flaring activity in GRB 100728A

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2011-05-26

Here, we present the simultaneous Swift and Fermi observations of the bright GRB 100728A and its afterglow. The early X-ray emission is dominated by a vigorous flaring activity continuing until 1 ks after the burst. In the same time interval, high-energy emission is significantly detected by the Fermi/Large Area Telescope. Marginal evidence of GeV emission is observed up to later times. As a result, we discuss the broadband properties of this burst within both the internal and external shock scenarios, with a particular emphasis on the relation between X-ray flares, the GeV emission, and a continued long-duration central engine activitymore » as their power source.« less

The Deafening Silence: Discussing Children's Drawings for Understanding and Addressing Marginalization

ERIC Educational Resources Information Center

Angelides, Panayiotis; Michaelidou, Antonia

2009-01-01

Researchers who deal with inclusive education have made great efforts to listen to the voices of children in order to understand marginalization. Despite the fact that these efforts take place, the voices of many children fail to be heard and hence many children continue to be marginalized. In this article we will develop and implement a technique…

Improved Nazca slab structure from teleseismic P-wave tomography along the Andean margin

NASA Astrophysics Data System (ADS)

Portner, D. E.; Beck, S. L.; Scire, A. C.; Zandt, G.

2017-12-01

South America marks the longest continuous ocean-continent subduction zone. As such, there is significant along-strike variability in the subducting Nazca slab structure and the tectonics of the South American margin. Most notably two gaps in the otherwise continuous volcanic arc are correlated with regions of flat slab subduction, indicating that the structure of the Nazca slab plays a controlling role in South American tectonics. Traditionally in subduction zones, our knowledge of slab structure is defined by Wadati-Benioff zone earthquakes. While this method allows for the determination of large-scale variations in Nazca slab structure such as regions of flat slab subduction, a scarcity of intermediate-depth earthquakes hinders our ability to observe the smaller-scale structural variations in the slab that may be critical to our understanding of the geologic record. We use an updated, larger dataset for finite-frequency teleseismic P-wave tomography including relative arrival times from >700 seismic stations along the Andean margin to image the detailed Nazca slab structure throughout the upper mantle and uppermost lower mantle between latitudes 5°S and 45°S. Our results show prominent variations in slab character along the margin. Slab dip varies significantly, from sub-vertical inboard of the Peruvian flat slab segment to 30° dip south of the Pampean flat slab, while the slab's velocity anomaly amplitude changes dramatically near the Pampean flat slab region. High slab velocities north of the Pampean region relative to the south indicate variable slab thermal structures that correspond roughly with the locations of deep (>500 km depth) earthquakes that also occur exclusively north of the Pampean region. Additionally, a wider regional footprint increases our sampling of the upper-lower mantle boundary, improving constraints on the slab's interaction with the 660 km discontinuity along strike. We see that the Nazca slab appears to penetrate into the lower mantle along the majority of the margin.

Ductile extension of syn-magmatic lower crusts, with application to volcanic passive margins: the Ivrea Zone (Southern Alps, Italy)

NASA Astrophysics Data System (ADS)

Bidault, Marie; Geoffroy, Laurent; Arbaret, Laurent; Aubourg, Charles

2017-04-01

Deep seismic reflection profiles of present-day volcanic passive margins often show a 2-layered lower crust, from top to bottom: an apparently ductile 12 km-thick middle-lower layer (LC1) of strong folded reflectors and a 4 km-thick supra-Moho layer (LC2) of horizontal and parallel reflectors. Those layers appear to be structurally disconnected and to develop at the early stages of margins evolution. A magmatic origin has been suggested by several studies to explain those strong reflectors, favoring mafic sills intrusion hypothesis. Overlying mafic and acidic extrusives (Seaward Dipping Reflectors sequences) are bounded by continentward-dipping detachment faults rooting in, and co-structurated with, the ductile part of the lower crust (LC1). Consequently the syn-rift to post-rift evolution of volcanic passive margins (and passive margins in general) largely depends on the nature and the properties of the lower crust, yet poorly understood. We propose to investigate the properties and rheology of a magma-injected extensional lower crust with a field analogue, the Ivrea Zone (Southern Alps, Italy). The Ivrea Zone displays a complete back-thrusted section of a Variscan continental lower crust that first underwent gravitational collapse, and then lithospheric extension. This Late Paleozoic extension was apparently associated with the continuous intrusion of a large volume of mafic to acid magma. Both the magma timing and volume, and the structure of the Ivrea lower crust suggest that this section represents an adequate analogue of a syn-magmatic in-extension mafic rift zone which aborted at the end of the Permian. Notably, we may recognize the 2 layers LC1 and LC2. From a number of tectonic observations, we reconstitute the whole tectonic history of the area, focusing on the strain field evolution with time, in connection with mafic magma injection. We compare those results with available data from extensional mafic lower crusts at rifts and margins.

Continuous Shear Wave Signals from around a Subducted Seamount Following 2014 Mw 6.8 Slow-slip Event in the Hikurangi Subduction Margin Offshore New Zealand

NASA Astrophysics Data System (ADS)

Iwasaki, Y.; Mochizuki, K.; Ishise, M.; Todd, E. K.; Schwartz, S. Y.; Henrys, S. A.; Savage, M. K.; Sheehan, A.; Ito, Y.; Wallace, L.; Webb, S. C.; Zal, H. J.; Yamada, T.; Shinohara, M.

2017-12-01

From May 2014 to June 2015 a marine seismic and geodetic experiment was conducted at the Hikurangi subduction margin. During this experiment, a slow-slip event (SSE) with equivalent moment magnitude of Mw 6.8 occurred for two weeks starting in late September 2014, directly beneath the ocean bottom seismometer (OBS) network (Wallace et al., 2016). In this study, we used the continuous waveform data recorded by these OBSs. We calculated a cross correlation coefficient between the two horizontal components and applied a polarization analysis every 10 seconds for 30 second-long OBS waveform records. As a result, we detected the continuous arrival of S-wave signals that appeared to have started in the latter half of the SSE. This continuous signal was identified as tremor and its source location was determined by the envelope cross-correlation method (Todd et al., 2017, in prep). Our result, however, suggests that these signals occur continuously rather than as sporadic individual events, and that they last for more than two weeks. Polarization directions changed at the same time and then remained stable through the two week duration. Such stable polarized directions can only be identified during this period. Our analysis requires fewer OBS than other methods for monitoring such S-wave signals, which may enable us to detect as yet unidentified signals in the Hikurangi margin where seismic attenuation has been shown to be large. The continuous signals with a stable polarization direction were only observed at OBS stations in a limited region, which suggests that the signals were generated near the up-dip edge of the slow slip area and surrounding a subducted seamount. Sources of the continuous signals appear to have migrated from south to north . This observation is consistent with the location of individual tremors identified with envelope cross-correlation methods (Todd et al., 2017, in prep). The slow slip along the plate interface circumvented the subducted seamount (Wallace et al., 2016). By comparing our result with the slip distribution, we can put more constraints on relationship between frictional properties along the plate interface and subducting topographic features such as seamounts. Migration of the sources of the continuous signal may further provide us with information on rupture propagation of the slow slip.

The crustal structure of the southern Argentine margin

NASA Astrophysics Data System (ADS)

Becker, Katharina; Franke, Dieter; Schnabel, Michael; Schreckenberger, Bernd; Heyde, Ingo; Krawczyk, Charlotte M.

2012-06-01

Multichannel reflection seismic profiles, combined with gravimetric and magnetic data provide insight into the crustal structure of the southernmost Argentine margin, at the transition from a rifted to a transform margin and outline the extent of the North Falkland Graben. Based on these data, we establish a regional stratigraphic model for the post-rift sediments, comprising six marker horizons with a new formation in the Barremian/Lower Cretaceous. Our observations support that a N-S trending subsidiary branch of the North Falkland Graben continues along the continental shelf and slope to the Argentine basin. During the rift phase, a wide shelf area was affected by the E-W extension, subsequently forming the North Falkland Graben and the subsidiary branch along which finally breakup occurred. We propose the division of the margin in two segments: a N-S trending rifted margin and an E-W trending transform margin. This is further underpinned by crustal scale gravity modelling. Three different tectono-dynamic processes shaped the study area. (1) The Triassic/Early Jurassic extensional phase resulting in the formation of the North Falkland Graben and additional narrower rift grabens ended synchronously with the breakup of the South Atlantic in the early Valanginian. (2) Extensional phase related to the opening of the South Atlantic. (3) The transform margin was active in the study area from about Hauterivian times and activity lasted until late Cretaceous/early Cenozoic. Both, the rifted margin and the transform margin are magma-poor. Very limited structures may have a volcanic origin but are suggested to be post-rift. The oceanic crust was found to be unusually thin, indicating a deficit in magma supply during formation. These findings in combination with the proposed breakup age in the early Valanginian that considerably predates the formation of the Paraná-Etendeka continental flood basalt provinces in Brazil and Namibia question the influence of the Tristan da Cunha hotspot during the initial formation of the South Atlantic.

Analysis of Longitudinal Studies With Repeated Outcome Measures: Adjusting for Time-Dependent Confounding Using Conventional Methods.

PubMed

Keogh, Ruth H; Daniel, Rhian M; VanderWeele, Tyler J; Vansteelandt, Stijn

2018-05-01

Estimation of causal effects of time-varying exposures using longitudinal data is a common problem in epidemiology. When there are time-varying confounders, which may include past outcomes, affected by prior exposure, standard regression methods can lead to bias. Methods such as inverse probability weighted estimation of marginal structural models have been developed to address this problem. However, in this paper we show how standard regression methods can be used, even in the presence of time-dependent confounding, to estimate the total effect of an exposure on a subsequent outcome by controlling appropriately for prior exposures, outcomes, and time-varying covariates. We refer to the resulting estimation approach as sequential conditional mean models (SCMMs), which can be fitted using generalized estimating equations. We outline this approach and describe how including propensity score adjustment is advantageous. We compare the causal effects being estimated using SCMMs and marginal structural models, and we compare the two approaches using simulations. SCMMs enable more precise inferences, with greater robustness against model misspecification via propensity score adjustment, and easily accommodate continuous exposures and interactions. A new test for direct effects of past exposures on a subsequent outcome is described.

78 FR 72639 - Non-Malleable Cast Iron Pipe Fittings From the People's Republic of China: Final Results of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-03

... dumping margins likely to prevail is indicated in the ``Final Results of Sunset Review'' section of this... likelihood of continuation or recurrence of dumping and the magnitude of the margins likely to prevail if the... dumping margin likely to prevail [FR Doc. 2013-28952 Filed 12-2-13; 8:45 am] BILLING CODE 3510-DS-P ...

Herbivory at marginal populations: Consequences for maternal fitness and vegetative differentiation

NASA Astrophysics Data System (ADS)

Castilla, Antonio R.; Alonso, Conchita; Herrera, Carlos M.

2013-05-01

Margins of distribution of plant species constitute natural areas where the impact of the antagonistic interactions is expected to be higher and where changes in the dynamics of plant-herbivore coevolution could promote intraspecific differentiation in (co)evolving plant traits. In the present study, we investigated how differences in the average herbivory level affect maternal fitness in core continuous and marginal disjunct populations of Daphne laureola in an effort to assess the role of herbivores limiting plant distribution. Furthermore, we investigated intraspecific differentiation in vegetative traits and their potential connection to divergent selection by herbivores in both groups of populations. Our results did not support increased herbivory at the species margin but did support a difference in the effect of herbivory on maternal fitness between core continuous and marginal disjunct populations of D. laureola. In addition, herbivores did not exert phenotypic selection consistent with the geographic variation in studied plant traits. Therefore, the geographic variation of vegetative traits of D. laureola seems to be consequence of environmental heterogeneity more than result of geographically divergent selection by herbivores.

Magnetospheric State of Sawtooth Events

NASA Technical Reports Server (NTRS)

Fung, Shing F.; Tepper, Julia A.; Cai, Xia

2016-01-01

Magnetospheric sawtooth events, first identified in the early 1990s, are named for their characteristic appearance of multiple quasiperiodic intervals of slow decrease followed by sharp increase of proton differential energy fluxes in the geosynchronous region. The successive proton flux oscillations have been interpreted as recurrences of stretching and dipolarization of the nightside geomagnetic field. Due to their often extended intervals with 210 cycles, sawteeth occurrences are sometimes referred to as a magnetospheric mode. While studies of sawtooth events over the past two decades have yielded a wealth of information about such events, the magnetospheric state conditions for the occurrence of sawtooth events and how sawtooth oscillations may depend on the magnetospheric state conditions remain unclear. In this study, we investigate the characteristic magnetospheric state conditions (specified by Psw interplanetary magnetic field (IMF) Btot, IMF Bz Vsw, AE, Kp and Dst, all time shifted with respect to one another) associated with the intervals before, during, and after sawteeth occurrences. Applying a previously developed statistical technique, we have determined the most probable magnetospheric states propitious for the development and occurrence of sawtooth events, respectively. The statistically determined sawtooth magnetospheric state has also been validated by using out-of-sample events, confirming the notion that sawtooth intervals might represent a particular global state of the magnetosphere. We propose that the sawtooth state of the magnetosphere may be a state of marginal stability in which a slight enhancement in the loading rate of an otherwise continuous loading process can send the magnetosphere into the marginally unstable regime, causing it to shed limited amount of energy quickly and return to the marginally stable regime with the loading process continuing. Sawtooth oscillations result as the magnetosphere switches between the marginally stable (loading) and unstable (unloading) phases.

Alpine inversion of the North African margin and delamination of its continental lithosphere

NASA Astrophysics Data System (ADS)

Roure, FrançOis; Casero, Piero; Addoum, Belkacem

2012-06-01

This paper aims at summarizing the current extent and architecture of the former Mesozoic passive margin of North Africa from North Algeria in the west up to the Ionian-Calabrian arc and adjacent Mediterranean Ridge in the east. Despite that most paleogeographic models consider that the Eastern Mediterranean Basin as a whole is still underlain by remnants of the Permo-Triassic or a younger Cretaceous Tethyan-Mesogean ocean, the strong similarities documented here in structural styles and timing of inversion between the Saharan Atlas, Sicilian Channel and the Ionian abyssal plain evidence that this portion of the Eastern Mediterranean Basin still belongs to the distal portion of the North African continental margin. A rim of Tethyan ophiolitic units can be also traced more or less continuously from Turkey and Cyprus in the east, in onshore Crete, in the Pindos in Greece and Mirdita in Albania, as well as in the Western Alps, Corsica and the Southern Apennines in the west, supporting the hypothesis that both the Apulia/Adriatic domain and the Eastern Mediterranean Basin still belong to the former southern continental margin of the Tethys. Because there is no clear evidence of crustal-scale fault offsetting the Moho, but more likely a continuous yet folded Moho extending between the foreland and the hinterland beneath the Mediterranean arcs, we propose here a new model of delamination of the continental lithosphere for the Apennines and the Aegean arcs. In this model, only the mantle lithosphere of Apulia and the Eastern Mediterranean is still locally subducted and recycled in the asthenosphere, most if not all the northern portion of the African crust and coeval Moho being currently decoupled from its former, currently delaminated and subducted mantle lithosphere.

Acceptance Testing of a Satellite SCADA Photovoltaic-Diesel Hybrid System

NASA Technical Reports Server (NTRS)

Kalu, A.; Emrich, C.; Ventre, G.; Wilson, W.; Acosta, Roberto (Technical Monitor)

2000-01-01

Satellite Supervisory Control and Data Acquisition (SCADA) of a Photovoltaic (PV)/diesel hybrid system was tested using NASA's Advanced Communication Technology Satellite (ACTS) and Ultra Small Aperture Terminal (USAT) ground stations. The setup consisted of a custom-designed PV/diesel hybrid system, located at the Florida Solar Energy Center (FSEC), which was controlled and monitored at a "remote" hub via Ka-band satellite link connecting two 1/4 Watt USATs in a SCADA arrangement. The robustness of the communications link was tested for remote monitoring of the health and performance of a PV/diesel hybrid system, and for investigating load control and battery charging strategies to maximize battery capacity and lifetime, and minimize loss of critical load probability. Baseline hardware performance test results demonstrated that continuous two-second data transfers can be accomplished under clear sky conditions with an error rate of less than 1%. The delay introduced by the satellite (1/4 sec) was transparent to synchronization of satellite modem as well as to the PV/diesel-hybrid computer. End-to-end communications link recovery times were less than 36 seconds for loss of power and less than one second for loss of link. The system recovered by resuming operation without any manual intervention, which is important since the 4 dB margin is not sufficient to prevent loss of the satellite link during moderate to heavy rain. Hybrid operations during loss of communications link continued seamlessly but real-time monitoring was interrupted. For this sub-tropical region, the estimated amount of time that the signal fade will exceed the 4 dB margin is about 10%. These results suggest that data rates of 4800 bps and a link margin of 4 dB with a 1/4 Watt transmitter are sufficient for end-to-end operation in this SCADA application.

Assessment of Surgical Learning Curves in Transoral Robotic Surgery for Squamous Cell Carcinoma of the Oropharynx

PubMed Central

Albergotti, William G.; Gooding, William E.; Kubik, Mark W.; Geltzeiler, Mathew; Kim, Seungwon; Duvvuri, Umamaheswar; Ferris, Robert L.

2017-01-01

IMPORTANCE Transoral robotic surgery (TORS) is increasingly employed as a treatment option for squamous cell carcinoma of the oropharynx (OPSCC). Measures of surgical learning curves are needed particularly as clinical trials using this technology continue to evolve. OBJECTIVE To assess learning curves for the oncologic TORS surgeon and to identify the number of cases needed to identify the learning phase. DESIGN, SETTING, AND PARTICIPANTS A retrospective review of all patients who underwent TORS for OPSCC at the University of Pittsburgh Medical Center between March 2010 and March 2016. Cases were excluded for involvement of a subsite outside of the oropharynx, for nonmalignant abnormality or nonsquamous histology, unknown primary, no tumor in the main specimen, free flap reconstruction, and for an inability to define margin status. EXPOSURES Transoral robotic surgery for OPSCC. MAIN OUTCOMES AND MEASURES Primary learning measures defined by the authors include the initial and final margin status and time to resection of main surgical specimen. A cumulative sum learning curve was developed for each surgeon for each of the study variables. The inflection point of each surgeon’s curve was considered to be the point signaling the completion of the learning phase. RESULTS There were 382 transoral robotic procedures identified. Of 382 cases, 160 met our inclusion criteria: 68 for surgeon A, 37 for surgeon B, and 55 for surgeon C. Of the 160 included patients, 125 were men and 35 were women. The mean (SD) age of participants was 59.4 (9.5) years. Mean (SD) time to resection including robot set-up was 79 (36) minutes. The inflection points for the final margin status learning curves were 27 cases (surgeon A) and 25 cases (surgeon C). There was no inflection point for surgeon B for final margin status. Inflection points for mean time to resection were: 39 cases (surgeon A), 30 cases (surgeon B), and 27 cases (surgeon C). CONCLUSIONS AND RELEVANCE Using metrics of positive margin rate and time to resection of the main surgical specimen, the learning curve for TORS for OPSCC is surgeon-specific. Inflection points for most learning curves peak between 20 and 30 cases. PMID:28196200

The End of Tethys: Opening and Closing of Oceans between Australia, India and SE Asia

NASA Astrophysics Data System (ADS)

Hall, R.

2008-12-01

SE Asia has grown by closure of Tethyan oceans south of Asia, principally by addition of fragments rifted from the Gondwana margins, resulting in a mosaic of continental crust and arc/ophiolite sutures. A new reconstruction identifies the blocks rifted from West and NW Australia in the Late Jurassic. They are now in Borneo, Java and Sulawesi, not West Burma as often assumed. Rifting in the Banda and Argo regions began at about 160 Ma, possibly due to south-directed subduction at the north Gondwana margin. Greater India is proposed to have extended north to the northern edge of the Exmouth Plateau and began to separate from Australia at about 140 Ma. The Banda and Argo blocks collided with the SE Asian margin between 110 and 90 Ma. At 90 Ma the Woyla intra-oceanic arc also collided with the Sumatra margin. This terminated subduction beneath Sundaland. The Indian and Australian plates were separated by a leaky transform from about 90 to 75 Ma which became a slightly convergent transform from about 75 to 55 Ma. This transform boundary is considered the eastern end of Tethys from the mid Cretaceous. There was a completely different history of subduction north of India compared to that north of Australia. The subduction history is recorded in the deep mantle by distinctive velocity anomalies which change from east to west abruptly at about 110°E. Between 90 and 45 Ma, India moved rapidly north with north-directed subduction within Tethys and at the Asian margin. It collided with an intra-oceanic arc at about 57 Ma, west of Sumatra, but continued to move north. The first contact of India with Asia was probably about 45 Ma, an estimate dependent on the shape of Greater India and the Asian margin; final ocean closure was later. North of Australia, between 90 and 45 Ma, there was no subduction beneath Sumatra and Java. During this interval south Sundaland was a mainly passive margin with some strike-slip deformation and extension. At 45 Ma Australia began to move north and subduction resumed beneath Indonesia. This was a time of major changes in lengths of subduction boundaries which may be of global importance. Subduction has continued to the present. The structure of the now-subducted ocean floor south of Indonesia, and the rifted NW Australian margin, subsequently influenced the Cenozoic development of SE Asia.

Climate change threatens the world's marine protected areas

NASA Astrophysics Data System (ADS)

Bruno, John F.; Bates, Amanda E.; Cacciapaglia, Chris; Pike, Elizabeth P.; Amstrup, Steven C.; van Hooidonk, Ruben; Henson, Stephanie A.; Aronson, Richard B.

2018-06-01

Marine protected areas (MPAs) are a primary management tool for mitigating threats to marine biodiversity1,2. MPAs and the species they protect, however, are increasingly being impacted by climate change. Here we show that, despite local protections, the warming associated with continued business-as-usual emissions (RCP8.5)3 will likely result in further habitat and species losses throughout low-latitude and tropical MPAs4,5. With continued business-as-usual emissions, mean sea-surface temperatures within MPAs are projected to increase 0.035 °C per year and warm an additional 2.8 °C by 2100. Under these conditions, the time of emergence (the year when sea-surface temperature and oxygen concentration exceed natural variability) is mid-century in 42% of 309 no-take marine reserves. Moreover, projected warming rates and the existing `community thermal safety margin' (the inherent buffer against warming based on the thermal sensitivity of constituent species) both vary among ecoregions and with latitude. The community thermal safety margin will be exceeded by 2050 in the tropics and by 2150 for many higher latitude MPAs. Importantly, the spatial distribution of emergence is stressor-specific. Hence, rearranging MPAs to minimize exposure to one stressor could well increase exposure to another. Continued business-as-usual emissions will likely disrupt many marine ecosystems, reducing the benefits of MPAs.

Subsea ice-bearing permafrost on the U.S. Beaufort Margin: 1. Minimum seaward extent defined from multichannel seismic reflection data

USGS Publications Warehouse

Brothers, Laura; Herman, Bruce M.; Hart, Patrick E.; Ruppel, Carolyn D.

2016-01-01

Subsea ice-bearing permafrost (IBPF) and associated gas hydrate in the Arctic have been subject to a warming climate and saline intrusion since the last transgression at the end of the Pleistocene. The consequent degradation of IBPF is potentially associated with significant degassing of dissociating gas hydrate deposits. Previous studies interpreted the distribution of subsea permafrost on the U.S. Beaufort continental shelf based on geographically sparse data sets and modeling of expected thermal history. The most cited work projects subsea permafrost to the shelf edge (∼100 m isobath). This study uses a compilation of stacking velocity analyses from ∼100,000 line-km of industry-collected multichannel seismic reflection data acquired over 57,000 km2 of the U.S. Beaufort shelf to delineate continuous subsea IBPF. Gridded average velocities of the uppermost 750 ms two-way travel time range from 1475 to 3110 m s−1. The monotonic, cross-shore pattern in velocity distribution suggests that the seaward extent of continuous IBPF is within 37 km of the modern shoreline at water depths < 25 m. These interpretations corroborate recent Beaufort seismic refraction studies and provide the best, margin-scale evidence that continuous subsea IBPF does not currently extend to the northern limits of the continental shelf.

Influence of artificial aging in marginal adaptation of mixed class V cavities.

PubMed

Tonetto, Mateus Rodrigues; Bandéca, Matheus Coelho; Barud, Hélida Gomes de Oliveira; Pinto, Shelon Cristina Souza; Lima, Darlon Martins; Borges, Alvaro Henrique; de Campos, Edson Alves; de Andrade, Marcelo Ferrarezi

2013-03-01

The aim of this study was to investigate whether the artificial aging by thermal cycling had influenced the marginal adaptation of class V restorations with/without chlorhexidine application in the bond process. Twelve intact human third molars were used. Class V cavity preparations were performed on the buccal surface and the teeth received 35% phosphoric acid-etching procedure (Ultradent Products Inc., South Jordan, Utah, USA). Subsequently, the samples were divided in two groups: Untreated acid-etched dentin and chlorhexidine application as an adjunct in the bond process. The adhesive Single Bond 2 (3M ESPE, St. Paul, MN, USA) was used after 2% chlorhexidine application, and the restorations were performed with Filtek™ Z350 XT (3M ESPE) composite resin. The specimens were submitted to artificial aging by thermal cycling with 3,000 cycles. Analyzes were performed on scanning electron microscopy using replicas of marginal adaptation in percentage of continuous margin before and after the artificial aging. The data were analyzed by paired test and the results showed statistically significant differences in the percentage of continuous margin with/without chlorhexidine treatment before and after thermal cycling. This study concluded that the artificial aging by thermal cycling influenced the marginal adaptation of mixed class V composite restorations.

Estimation of Inherent Safety Margins in Loaded Commercial Spent Nuclear Fuel Casks

DOE PAGES

Banerjee, Kaushik; Robb, Kevin R.; Radulescu, Georgeta; ...

2016-06-15

We completed a novel assessment to determine the unquantified and uncredited safety margins (i.e., the difference between the licensing basis and as-loaded calculations) available in as-loaded spent nuclear fuel (SNF) casks. This assessment was performed as part of a broader effort to assess issues and uncertainties related to the continued safety of casks during extended storage and transportability following extended storage periods. Detailed analyses crediting the actual as-loaded cask inventory were performed for each of the casks at three decommissioned pressurized water reactor (PWR) sites to determine their characteristics relative to regulatory safety criteria for criticality, thermal, and shielding performance.more » These detailed analyses were performed in an automated fashion by employing a comprehensive and integrated data and analysis tool—Used Nuclear Fuel-Storage, Transportation & Disposal Analysis Resource and Data System (UNF-ST&DARDS). Calculated uncredited criticality margins from 0.07 to almost 0.30 Δk eff were observed; calculated decay heat margins ranged from 4 to almost 22 kW (as of 2014); and significant uncredited transportation dose rate margins were also observed. The results demonstrate that, at least for the casks analyzed here, significant uncredited safety margins are available that could potentially be used to compensate for SNF assembly and canister structural performance related uncertainties associated with long-term storage and subsequent transportation. The results also suggest that these inherent margins associated with how casks are loaded could support future changes in cask licensing to directly or indirectly credit the margins. Work continues to quantify the uncredited safety margins in the SNF casks loaded at other nuclear reactor sites.« less

17 CFR 242.402 - General provisions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false General provisions. 242.402 Section 242.402 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer Margin...

A comparison of the South China Sea and Canada Basin: two small marginal ocean basins with hyper-extended margins and central zones of sea-floor spreading.

NASA Astrophysics Data System (ADS)

Li, L.

2015-12-01

Both the South China Sea and Canada Basin preserve oceanic spreading centres and adjacent passive continental margins characterized by broad COT zones with hyper-extended continental crust. We have investigated the nature of strain accommodation in the regions immediately adjacent to the oceanic spreading centres in these two basins using 2-D backstripping subsidence reconstructions, coupled with forward modelling constrained by estimates of upper crustal extensional faulting. Modelling is better constrained in the South China Sea but our results for the Beaufort Sea are analogous. Depth-dependent extension is required to explain the great depth of both basins because only modest upper crustal faulting is observed. A weak lower crust in the presence of high heat flow is suggested for both basins. Extension in the COT may continue even after sea-floor spreading has ceased. The analogous results for the two basins considered are discussed in terms of (1) constraining the timing and distribution of crustal thinning along the respective continental margins, (2) defining the processes leading to hyper-extension of continental crust in the respective tectonic settings and (3) illuminating the processes that control hyper-extension in these basins and more generally.

Low post-Cenomanian denudation depths across the Brazilian Northeast: Implications for long-term landscape evolution at a transform continental margin

NASA Astrophysics Data System (ADS)

Peulvast, Jean-Pierre; Claudino Sales, Vanda; Bétard, François; Gunnell, Yanni

2008-05-01

The Brazilian Northeast affords good opportunities for obtaining reliable timings and rates of landscape evolution based on stratigraphic correlations across a vast region. The landscape formed in the context of an episodically fluctuating but continuously falling base level since the Cenomanian. After formation of the transform passive margin in Aptian times, landscape development was further driven by a swell-like uplift with its crest situated ˜ 300 km from the coastline. The seaward flank of this swell or broad monocline between the interior Araripe and coastal Potiguar basins was eroded, and currently forms a deeply embayed plain bordered by a semi-circular, north-facing erosional escarpment. The post-Cenomanian uplift caused an inversion of the Cretaceous basins and generated a landscape in which the most elevated landforms correspond either to resistant Mesozoic sedimentary caprock, or to eroded stumps of syn-rift Cretaceous footwall uplands. Denudation in the last 90 My never exceeded mean rates of 10 m·My - 1 and exhumed a number of Cretaceous stratigraphic unconformities. As a result, some topographic surfaces at low elevations are effectively Mesozoic land surfaces that became re-exposed in Cenozoic times. The Neogene Barreiras Formation forms a continuous and mostly clastic apron near the coast. It testifies to the last peak of erosion in the hinterland and coincided with the onset of more arid climates at ˜ 13 Ma or earlier. The semi-circular escarpment is not directly related to the initial breakup rift flanks, which had been mostly eroded before the end of the Mesozoic, but the cause and exact timing of post-Cenomanian crustal upwarping are poorly constrained. It could perhaps have been a flexural response of the low-rigidity lithosphere to sediment loads on the margin, and thus a slowly ongoing process since the late Cretaceous. Uplift could instead be the consequence of a more discrete dynamic event related either to Oligocene magmatism in the region, or to continental-scale far-field stresses determined by Andean convergence.

After Saddam: Prewar Planning and the Occupation of Iraq

DTIC Science & Technology

2008-01-01

or capitulated” and “regime leaders dead, apprehended, or marginalized .” Finally, Franks briefed his overarching concept for Phase IV, “post...State Depart- ment officials believed that they were marginalized because State was seen as not supporting the possible war with Iraq.41 Whatever the...Future of Iraq project continued its work throughout 2002 and early 2003, the State Department as a whole remained on the margins of the postwar

Bounded Linear Stability Analysis - A Time Delay Margin Estimation Approach for Adaptive Control

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.; Ishihara, Abraham K.; Krishnakumar, Kalmanje Srinlvas; Bakhtiari-Nejad, Maryam

2009-01-01

This paper presents a method for estimating time delay margin for model-reference adaptive control of systems with almost linear structured uncertainty. The bounded linear stability analysis method seeks to represent the conventional model-reference adaptive law by a locally bounded linear approximation within a small time window using the comparison lemma. The locally bounded linear approximation of the combined adaptive system is cast in a form of an input-time-delay differential equation over a small time window. The time delay margin of this system represents a local stability measure and is computed analytically by a matrix measure method, which provides a simple analytical technique for estimating an upper bound of time delay margin. Based on simulation results for a scalar model-reference adaptive control system, both the bounded linear stability method and the matrix measure method are seen to provide a reasonably accurate and yet not too conservative time delay margin estimation.

Margins Associated with Loss of Assured Safety for Systems with Multiple Time-Dependent Failure Modes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helton, Jon C.; Brooks, Dusty Marie; Sallaberry, Cedric Jean-Marie.

Representations for margins associated with loss of assured safety (LOAS) for weak link (WL)/strong link (SL) systems involving multiple time-dependent failure modes are developed. The following topics are described: (i) defining properties for WLs and SLs, (ii) background on cumulative distribution functions (CDFs) for link failure time, link property value at link failure, and time at which LOAS occurs, (iii) CDFs for failure time margins defined by (time at which SL system fails) – (time at which WL system fails), (iv) CDFs for SL system property values at LOAS, (v) CDFs for WL/SL property value margins defined by (property valuemore » at which SL system fails) – (property value at which WL system fails), and (vi) CDFs for SL property value margins defined by (property value of failing SL at time of SL system failure) – (property value of this SL at time of WL system failure). Included in this presentation is a demonstration of a verification strategy based on defining and approximating the indicated margin results with (i) procedures based on formal integral representations and associated quadrature approximations and (ii) procedures based on algorithms for sampling-based approximations.« less

An environmental chamber system for prolonged metabolic studies on small animals

NASA Technical Reports Server (NTRS)

Jordan, J. P.; Huston, L. J.; Simmons, J. B., II; Clarkson, D. P.; Martz, W. W.; Schatte, C. L.

1973-01-01

Measurement of metabolic adaptation to marginally stressful environments requires both precise regulation of a variety of atmospheric factors for extended periods of time and the capacity to employ sensitive parameters in an undisturbed subject. This paper describes a metabolic chamber system which can simultaneously maintain groups of small animals in two completely separate closed environments having different pressures, temperatures and gas compositions for an indefinite period. Oxygen consumption, carbon dioxide production, food and water consumption and animal activity cycles can be continuously monitored and quantified 24 h per day while the animals are in an unrestrained state. Each chamber can be serviced and the animals handled, injected and sacrificed without subjecting them to barometric stress. Several unique electrical and mechanical components allow semi-automated data collection on a continuous basis for indefinite periods of time.

Influence of Cavity Margin Design and Restorative Material on Marginal Quality and Seal of Extended Class II Resin Composite Restorations In Vitro.

PubMed

Soliman, Sebastian; Preidl, Reinhard; Karl, Sabine; Hofmann, Norbert; Krastl, Gabriel; Klaiber, Bernd

2016-01-01

To investigate the influence of three cavity designs on the marginal seal of large Class II cavities restored with low-shrinkage resin composite limited to the enamel. One hundred twenty (120) intact human molars were randomly divided into 12 groups, with three different cavity designs: 1. undermined enamel, 2. box-shaped, and 3. proximal bevel. The teeth were restored with 1. an extra-low shrinkage (ELS) composite free of diluent monomers, 2. microhybrid composite (Herculite XRV), 3. nanohybrid composite (Filtek Supreme XTE), and 4. silorane-based composite (Filtek Silorane). After artificial aging by thermocycling and storage in physiological saline, epoxy resin replicas were prepared. To determine the integrity of the restorations' approximal margins, two methods were sequentially employed: 1. replicas were made of the 120 specimens and examined using SEM, and 2. the same 120 specimens were immersed in AgNO3 solution, and the dye penetration depth was observed with a light microscope. Statistical analysis was performed using the Kruskal-Wallis and the Dunn-Bonferroni tests. After bevel preparation, SEM observations showed that restorations did not exhibit a higher percentage of continuous margin (SEM-analysis; p>0.05), but more leakage was found than with the other cavity designs (p<0.05). The lowest percentage of continuous margin was observed in ELS restorations (p<0.05). More fractured margins were observed in the undermined enamel cavity design groups (p<0.05). Bevel preparation failed to improve margin quality in large Class II composite restorations and is no longer recommended. However, undermined enamel should be removed to prevent enamel fractures.

Gamma knife radiosurgery for vestibular schwannomas: tumor control and functional preservation in 70 patients.

PubMed

Arthurs, Benjamin J; Lamoreaux, Wayne T; Mackay, Alexander R; Demakas, John J; Giddings, Neil A; Fairbanks, Robert K; Cooke, Barton S; Elaimy, Ameer L; Peressini, Ben; Lee, Christopher M

2011-06-01

We present the previously unreported outcomes of 70 patients treated with Gamma knife radiosurgery for vestibular schwannoma (VS), including comprehensive analysis of clinical outcomes and the effects of lower marginal doses. We performed a retrospective study of patients treated for VS at Gamma knife of Spokane between 2003 and 2008. Endpoints measured include tumor control, hearing preservation, and facial nerve preservation, including the effect of tumor size and marginal dose. Statistical analysis was performed with Wilcoxon signed-rank test, paired Student t test, Mann-Whitney U test, Kendall's rank correlation, Fisher exact test, and Liddell's exact χ(2) test for matched pairs. With a mean follow-up of 26 months, 93.8% of tumors either shrank or remained static after receiving a mean marginal dose of 12.7 Gy. Tumor control was independent of marginal dose or tumor size. Hearing preservation was achieved in 64% of patients with serviceable function before the treatment. Hearing changes were independent of dose or tumor size. Preservation of good facial nerve function was achieved in 95% of patients. Post-treatment hydrocephalus occurred in 4.4% of patients, but no other significant morbidities were elucidated. In the treatment of VS, contemporary radiosurgical techniques and the use of marginal doses below 13 Gy offer excellent tumor control, at high rates relative to surgical intervention. These findings are independent of marginal dose and tumor size. Patients should be informed about the benefits and risks of radiosurgery and microsurgery before choosing an intervention. Further analysis of post-treatment outcomes should be encouraged as follow-up times increase and the treatment protocols continue to evolve.

The George V Land Continental Margin (East Antarctica): new Insights Into Bottom Water Production and Quaternary Glacial Processes from the WEGA project

NASA Astrophysics Data System (ADS)

Caburlotto, A.; de Santis, L.; Lucchi, R. G.; Giorgetti, G.; Damiani, D.; Macri', P.; Tolotti, R.; Presti, M.; Armand, L.; Harris, P.

2004-12-01

The George Vth Land represents the ending of one of the largest subglacial basin (Wilkes Basin) of the East Antarctic Ice Sheet (EAIS). Furthermore, its coastal areas are zone of significant production of High Salinity Shelf Water (HSSW). Piston and gravity cores and high resolution echo-sounding (3.5 kHz) and Chirp profiles collected in the frame of the joint Australian and Italian WEGA (WilkEs Basin GlAcial History) project provide new insights into the Quaternary history of the EAIS and the HSSW across this margin: from the sediment record filling and draping valleys and banks along the continental shelf, to the continuous sedimentary section of the mound-channel system on the continental rise. The discovery of a current-lain sediment drift (Mertz Drift, MD) provides clues to understanding the age of the last glacial erosive events, as well as to infer flow-pathways of bottom-water masses changes. The MD shows disrupted, fluted reflectors due to glacial advance during the LGM (Last Glacial Maximum) in shallow water, while undisturbed sediment drift deposited at greater water depth, indicates that during the LGM the ice shelf was floating over the deep sector of the basin. The main sedimentary environment characterising the modern conditions of the continental rise is dominated by the turbiditic processes with a minor contribution of contour currents action. Nevertheless, some areas (WEGA Channel) are currently characterised by transport and settling of sediment through HSSW, originating in the shelf area. This particular environment likely persisted since pre-LGM times. It could indicate a continuous supply of sedimentary material from HSSW during the most recent both glacial and interglacial cycles. This would be consistent with the results obtained in the continental shelf suggesting that the Ice Sheet was not grounding over some parts of the continental shelf. Furthermore, the comparison of the studied area with other Antarctic margins indicate that, contrary to what happens on the Antarctic Peninsula margin, the relation between the Quaternary sedimentation and the glacial - interglacial cycles are less evident in the lithofacies observed on the continental rise area. This characteristic suggests a different glacial dynamic along the Wilkes Land continental margin that is less sensitive to the small climatic changes, with respect to the western (Antarctic Peninsula) margin.

Effect of Cements at Different Temperatures on the Clinical Performance and Marginal Adaptation of Inlay-Onlay Restorations In Vivo.

PubMed

Aygün Emiroğlu, Şeyda; Evren, Buket; Kulak Özkan, Yasemin

2016-06-01

To evaluate the clinical performance of inlays and onlays luted with two different resin cements, mixed at different temperatures and to evaluate the marginal adaptation of the restorations. One hundred IPS e.max restorations (82 onlays, 18 inlays; 84 molars, 16 premolars) were placed in 50 patients (28 females, 22 males, mean age, 33 years). The restorations were assigned to six groups according to the luting agent temperature (25°C, 37°C, and 54°C) and cement type (Variolink N high viscosity or G-Cem Automix). All restorations were evaluated after 1 week and 1 year by two examiners using modified USPHS criteria. Replicas of 30 selected onlay restorations (5 per group) were assessed for marginal quality under a scanning electron microscope (SEM) at 200×. Marginal adaptation was quantitatively evaluated in terms of percentage of gap formation, and marginal gap width was measured. After 1 year, the total survival rates of the Variolink N high viscosity group and G-Cem Automix group were 100% and 93.8%, respectively. Three debondings occurred with the G-Cem Automix group, one from each temperature group. For 1-year clinical service time, no significant difference was noticed in the marginal adaptation of Variolink N high viscosity groups and the 37°C G-Cem Automix group, while 25°C and 54°C G-Cem Automix groups' marginal adaptation scores decreased (p < 0.05). Regarding the SEM evaluations, Variolink N high viscosity cement groups showed better marginal adaptation than G-Cem Automix cement groups (p < 0.05). Cementation with the cements preheated to 37°C increased continuous margins in both enamel-cement and cement-ceramic interfaces, but these results were not statistically significant (p > 0.05). Cements at different temperatures did not have significant effects on marginal gap widths of the restorations. The restorations cemented with Variolink N high viscosity cement mixed at the three tested temperatures exhibited better treatment options than the self-adhesive groups. Preheating the self-adhesive cement (G-Cem Automix) to 37°C can be an effective method to have better marginal adaptation than the other self-adhesive groups (25°C, 54°C) tested in this study. © 2015 by the American College of Prosthodontists.

Quantification of the effects of eustasy, subsidence, and sediment supply on Miocene sequences, mid-Atlantic margin of the United States

USGS Publications Warehouse

Browning, J.V.; Miller, K.G.; McLaughlin, P.P.; Kominz, M.A.; Sugarman, P.J.; Monteverde, D.; Feigenson, M.D.; Hernandez, J.C.

2006-01-01

We use backstripping to quantify the roles of variations in global sea level (eustasy), subsidence, and sediment supply on the development of the Miocene stratigraphic record of the mid-Atlantic continental margin of the United States (New Jersey, Delaware, and Maryland). Eustasy is a primary influence on sequence patterns, determining the global template of sequences (i.e., times when sequences can be preserved) and explaining similarities in Miocene sequence architecture on margins throughout the world. Sequences can be correlated throughout the mid-Atlantic region with Sr-isotopic chronology (??0.6 m.y. to ??1.2 m.y.). Eight Miocene sequences correlate regionally and can be correlated to global ??18O increases, indicating glacioeustatic control. This margin is dominated by passive subsidence with little evidence for active tectonic overprints, except possibly in Maryland during the early Miocene. However, early Miocene sequences in New Jersey and Delaware display a patchwork distribution that is attributable to minor (tens of meters) intervals of excess subsidence. Backstripping quantifies that excess subsidence began in Delaware at ca. 21 Ma and continued until 12 Ma, with maximum rates from ca. 21-16 Ma. We attribute this enhanced subsidence to local flexural response to the progradation of thick sequences offshore and adjacent to this area. Removing this excess subsidence in Delaware yields a record that is remarkably similar to New Jersey eustatic estimates. We conclude that sea-level rise and fall is a first-order control on accommodation providing similar timing on all margins to the sequence record. Tectonic changes due to movement of the crust can overprint the record, resulting in large gaps in the stratigraphic record. Smaller differences in sequences can be attributed to local flexural loading effects, particularly in regions experiencing large-scale progradation. ?? 2006 Geological Society of America.

Tectonic evolution of the Paranoá basin: New evidence from gravimetric and stratigraphic data

NASA Astrophysics Data System (ADS)

Martins-Ferreira, Marco Antonio Caçador; Campos, José Eloi Guimarães; Von Huelsen, Monica Giannoccaro

2018-06-01

Field gravimetric and stratigraphic surveys were conducted with the aim to constraint the mechanisms responsible for the initiation of the Stenian-Tonian Paranoá basin, central Brazil, a subject not yet studied in detail. The Paranoá Group crops out in the external zone of the Brasília Belt, a Neoproterozoic orogen in the western margin of the São Francisco Craton. Detailed geological mapping confirmed the existence of a regional scale fault that controlled sedimentation of the Paranoá Group during the deposition of its basal formations, revealing important details about basin initiation and early evolution. Gravimetric modeling indicates the existence of paleorift structures beneath the Paranoá sequence in the study area. Results from both stratigraphic and gravimetric surveys show strong evidence of mechanical subsidence by faulting during basin initiation. Unsorted, angular, clasts cut by quartz veins and brecciated boulders present in the basal conglomerate, support this hypothesis. Basin initiation faults coincide with deeper paleorift faults and are thus interpreted as reactivations of the older Statherian Araí Rift. The reactivations favored an initial regime of mechanical subsidence, dominated by the development of epirogenic arches subsiding at different rates. Apart from faulting activity, the post-basal sequence presents no evidence of rift environment in the strict sense. Besides, the great lateral continuity and relatively constant thickness of facies, indicate that an initial mechanic subsidence rapidly gave way to flexural subsidence during subsequent stages of basin evolution. The Paranoá Group do not present reliable characteristics that would allow its strict classification as a passive margin. Its main stratigraphic characteristics, tectonic location and basement architecture, indicate that the Paranoá Group was deposited in a cratonic margin basin, and may have been either connected to a passive margin basin at times of sea level rise, or evolved to a passive margin later in time.

The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue.

PubMed

Wan, Yinan; Almeida, Alexandra D; Rulands, Steffen; Chalour, Naima; Muresan, Leila; Wu, Yunmin; Simons, Benjamin D; He, Jie; Harris, William A

2016-04-01

Clonal analysis is helping us understand the dynamics of cell replacement in homeostatic adult tissues (Simons and Clevers, 2011). Such an analysis, however, has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called the ciliary marginal zone (CMZ). Here, we show that RSCs reside in a niche at the extreme periphery of the CMZ and divide asymmetrically along a radial (peripheral to central) axis, leaving one daughter in the peripheral RSC niche and the other more central where it becomes an RPC. We also show that RPCs of the CMZ have clonal sizes and compositions that are statistically similar to progenitor cells of the embryonic retina and fit the same stochastic model of proliferation. These results link embryonic and postembryonic cell behaviour, and help to explain the constancy of tissue architecture that has been generated over a lifetime. © 2016. Published by The Company of Biologists Ltd.

Personal Control and Service Connection as Paths to Improved Mental Health and Exiting Homelessness among Severely Marginalized Homeless Youth.

PubMed

Slesnick, Natasha; Zhang, Jing; Brakenhoff, Brittany

2017-02-01

Non-service connected, continuously homeless youth are arguably one of the most vulnerable populations in the U.S. These youth reside at society's margins experiencing an accumulation of risks over time. Research concludes that as vulnerabilities increase so do poor long-term outcomes. This study tested the mediating effects of service connection and personal control as mediators of cumulative risk and housing, health and mental health outcomes. By understanding the processes associated with therapeutic change among those with the most vulnerabilities, service providers and researchers can target those factors to enhance positive outcomes. Seventy-nine, non-service connected, substance using homeless youth were offered a strengths-based outreach and engagement intervention and were assessed at baseline 3, 6 and 9 months post-baseline. Personal control mediated the effects of cumulative risk on housing stability, and service utilization mediated the effects of cumulative risk on mental health. This study specifies important targets of intervention for a population at high risk for continuing homelessness. In particular, service providers should target youths' sense of personal control and link them to needed community-based services in order to help them exit street life and improve mental health outcomes.

On Time Delay Margin Estimation for Adaptive Control and Optimal Control Modification

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.

2011-01-01

This paper presents methods for estimating time delay margin for adaptive control of input delay systems with almost linear structured uncertainty. The bounded linear stability analysis method seeks to represent an adaptive law by a locally bounded linear approximation within a small time window. The time delay margin of this input delay system represents a local stability measure and is computed analytically by three methods: Pade approximation, Lyapunov-Krasovskii method, and the matrix measure method. These methods are applied to the standard model-reference adaptive control, s-modification adaptive law, and optimal control modification adaptive law. The windowing analysis results in non-unique estimates of the time delay margin since it is dependent on the length of a time window and parameters which vary from one time window to the next. The optimal control modification adaptive law overcomes this limitation in that, as the adaptive gain tends to infinity and if the matched uncertainty is linear, then the closed-loop input delay system tends to a LTI system. A lower bound of the time delay margin of this system can then be estimated uniquely without the need for the windowing analysis. Simulation results demonstrates the feasibility of the bounded linear stability method for time delay margin estimation.

Adspots and Green Eyes: 'National' Identity in Irish TV Commercials and Other 'Marginal' Areas of Irish Television.

ERIC Educational Resources Information Center

McBride, Stephanie

This paper discusses the relationship between national identity and the so-called "marginal" areas of Irish television, i.e., advertisements, continuity announcements, and promotional trailers. The following issues are considered: (1) how these "spaces" between television programs compare in terms of use and influence to…

Aboriginal Business Capacity Building Programs in the Central Interior of British Columbia: A Collaborative Project between the University and Communities

ERIC Educational Resources Information Center

Kunkel, Titi; Schorcht, Blanca; Brazzoni, Randall

2011-01-01

Aboriginal communities in Canada are typically marginalized, have very low employment participation rates, and have limited economic infrastructure. The downturn in global economies further marginalized these communities. The University of Northern British Columbia's (UNBC) Continuing Studies department piloted an Aboriginal and Small Business…

Globalization on the Margins: Education and Post-Socialist Transformations in Central Asia

ERIC Educational Resources Information Center

Silova, Iveta

2010-01-01

The essays in "Globalization on the Margins" explore the continuities and changes in Central Asian education development since the collapse of the Soviet Union in 1991. Reflecting on two decades of post-socialist transformations, they reveal that education systems in Central Asia responded to the rapidly changing political, economic, and…

Unfolding the arc: The use of pre-orogenic constraints to assess the evolution of the Variscan belt in Western Europe

NASA Astrophysics Data System (ADS)

Casas, Josep M.; Brendan Murphy, J.

2018-06-01

We present a pre-orogenic, early Paleozoic, palinspastic reconstruction of the northern Gondwana margin that was subsequently involved in the Late Paleozoic Variscan orogeny in central and Western Europe. Our reconstruction is based on two pre-orogenic data sets, the age and distribution of Cambrian-Ordovician magmatism and the detrital zircon age signature of late Neoproterozoic-early Paleozoic clastic rocks. We obtain this reconstruction by unfolding the Ibero-Armorican arc and by restoring the movement of the large-scale dextral strike-slip faults that transect the different tectono-stratigraphic units. Our results favour an irregular shape for this part of the northern Gondwana margin with a N-S central segment linking two E-W oriented segments. The proposed reconstruction and the structural restoration of the main features of Variscan deformation is in accordance with some aspects of previously proposed structural models, such as the curved geometry of the Gondwanan margin required by the indentor model for continental collision, the role played by the large strike-slip faults in dispersing formerly juxtaposed units, and the regional-scale oroclinal folding of part of this margin during late Carboniferous-Early Permian times. The combined use of the pre-orogenic geological constraints and palinspastic restoration is a useful approach that may provide a foundation for continual refinement of reconstructions as more data become available.

Kaizen method for esophagectomy patients: improved quality control, outcomes, and decreased costs.

PubMed

Iannettoni, Mark D; Lynch, William R; Parekh, Kalpaj R; McLaughlin, Kelley A

2011-04-01

The majority of costs associated with esophagectomy are related to the initial 3 days of hospital stay requiring intensive care unit stays, ventilator support, and intraoperative time. Additional costs arise from hospital-based services. The major cost increases are related to complications associated with the procedure. We attempted to define these costs and identify expense management by streamlining care through strict adherence to patient care maps, operative standardization, and rapid discharge planning to reduce variability. Utilizing methods of Kaizen philosophy we evaluated all processes related to the entire experience of esophageal resection. This process has taken over 5 years to achieve, with quality and cost being tracked over this time period. Cost analysis included expenses related to intensive care unit, anesthesia, disposables, and hospital services. Quality improvement measures were related to intraoperative complications, in-hospital complications, and postoperative outcomes. The Institutional Review Board approved the use of anonymous data from standard clinical practice because no additional treatment was planned (observational study). Utilizing a continuous process improvement methodology, a 43% reduction in cost per case has been achieved with a significant increase in contribution margin for esophagectomy. The length of stay has been reduced from 14 days to 5. With intraoperative and postoperative standardization the leak rate has dropped from 12% to less than 3% to no leaks in our current Kaizen modification of care in our last 64 patients. Utilizing lean manufacturing techniques and continuous process evaluation we have attempted to eliminate variability, standardized the phases of care resulting in improved outcomes, decreased length of stay, and improved contribution margins. These Kaizen improvements require continuous interventions, strict adherence to care maps, and input from all levels for quality improvements. Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Duration of convergence at the Pacific-Gondwana plate margin: insights from accessory phase petrochronology of the Alpine Schist, New Zealand

NASA Astrophysics Data System (ADS)

Briggs, S. I.; Cottle, J. M.; Smit, M. A.; Arnush, N. F.

2016-12-01

The timing, duration and along-strike synchroneity of metamorphism and anataxis in the Alpine Schist of New Zealand is a matter of considerable debate. Our preliminary data indicate that metamorphism resulting in garnet growth occurred from 97 - 75 Ma, and anatectic melting occurred from 80 - 51 Ma. These events are contemporaneous with rifting of Zealandia from East Gondwana, and Tasman Sea spreading from 83 - 52 Ma. An important implication of these results is that Late Cretaceous convergence along the Zealandia segment of the Pacific-Gondwana plate margin may have persisted much later than previously thought, and that convergence and extension occurred coevally in adjacent areas. This poses the question: for how long did convergence continue along the Pacific-Gondwana plate margin during East Gondwana breakup? To fully decipher the multiple stages of the complex metamorphic history recorded in the Alpine Schist, we combine Lu-Hf garnet geochronology with U-Th/Pb and REE analyses of zircon and monazite. We use the newly developed `single-shot laser ablation split stream' (SS-LASS) analysis method to obtain depth profiles through 5-10 µm metamorphic zircon overgrowths at 100 nm depth resolution to constrain both the timing and petrological context of discrete metamorphic zircon (re-)crystallization events recorded in the Alpine Schist. We also employ high spatial resolution LASS analysis to target rare 5 - 20 µm monazite in thin section to augment garnet and zircon data. Our multi-accessory phase petrochronology approach is capable of resolving discrete short-duration thermal events, strengthening the geological interpretation of `mean' Lu-Hf garnet ages and discerning between an episodic versus a prolonged history of metamorphism. In addition, comparison with geochronology from anatectic pegmatites clarifies the temporal relationship between metamorphism and melting in the Alpine Schist, while providing direct constraints on the timing and duration of convergence along the Zealandia segment of the Pacific-Gondwana margin.

Quantitative description of solid breast nodules by ultrasound imaging

NASA Astrophysics Data System (ADS)

Sehgal, Chandra M.; Kangas, Sarah A.; Cary, Ted W.; Weinstein, Susan P.; Schultz, Susan M.; Arger, Peter H.; Conant, Emily F.

2004-04-01

Various features based on qualitative description of shape, contour, margin and echogenicity of solid breast nodules are used clinically to classify them as benign or malignant. However, there continues to be considerable overlap in the sonographic findings for the two types of lesions. This is related to the lack of precise definition of the various features as well as to the lack of agreement among observers, among other factors. The goal of this investigation is to define clinical features quantitatively and evaluate if they differ significantly in malignant and benign cases. Features based on margin sharpness and continuity, shadowing, and attenuation were defined and calculated from the images. These features were tested on digital phantoms. Following the evaluation, the features were measured on 116 breast sonograms of 58 biopsy-proven masses. Biopsy had been recommended for all of these breast lesions based on physical exams and conventional diagnostic imaging of ultrasound and/or mammography. Of the 58 masses, 20 were identified as malignant and 38 as benign histologically. Margin sharpness, margin echogenicity, and angular margin variation were significantly different for the two groups (p<0.03, two-tailed student t-test). Shadowing and attenuation of ultrasound did not show significant difference. The results of this preliminary study show that quantitative margin characteristics measured for the malignant and benign masses from the ultrasound images are different and could potentially be useful in identifying a subgroup of solid breast nodules that have low risk of being malignant.

The stochastic system approach for estimating dynamic treatments effect.

PubMed

Commenges, Daniel; Gégout-Petit, Anne

2015-10-01

The problem of assessing the effect of a treatment on a marker in observational studies raises the difficulty that attribution of the treatment may depend on the observed marker values. As an example, we focus on the analysis of the effect of a HAART on CD4 counts, where attribution of the treatment may depend on the observed marker values. This problem has been treated using marginal structural models relying on the counterfactual/potential response formalism. Another approach to causality is based on dynamical models, and causal influence has been formalized in the framework of the Doob-Meyer decomposition of stochastic processes. Causal inference however needs assumptions that we detail in this paper and we call this approach to causality the "stochastic system" approach. First we treat this problem in discrete time, then in continuous time. This approach allows incorporating biological knowledge naturally. When working in continuous time, the mechanistic approach involves distinguishing the model for the system and the model for the observations. Indeed, biological systems live in continuous time, and mechanisms can be expressed in the form of a system of differential equations, while observations are taken at discrete times. Inference in mechanistic models is challenging, particularly from a numerical point of view, but these models can yield much richer and reliable results.

Lacustrine Records of Holocene Mountain Glacier Fluctuations from Western Greenland

NASA Astrophysics Data System (ADS)

Schweinsberg, A.; Briner, J. P.; Bennike, O.

2014-12-01

Recent studies have focused on documenting fluctuations of the Greenland Ice Sheet margin throughout the Holocene but few data exist that constrain past changes of local glaciers independent of the ice sheet. Our research combines proglacial lake sediment analysis with cosmogenic 10Be dating of Holocene moraines and radiocarbon dating of ice-cap-killed vegetation with an overall objective to use this multi-proxy approach to generate a detailed record of the coupled climate-glacier system through the Holocene. Here, we present lacustrine records of mountain glacier variability from continuous pro-glacial lake sediment sequences recovered from two glaciated catchments in northeastern Nuussuaq, western Greenland. We use radiocarbon-dated sediments from Sikuiui and Pauiaivik lakes to reconstruct the timing of advance and retreat of local glaciers. Sediments were characterized with magnetic susceptibility (MS), gamma density, Itrax XRF and visible reflectance spectroscopy at 0.2 cm intervals and sediment organic matter at 0.5 cm intervals. Basal radiocarbon ages provide minimum-age constraints on deglaciation from Sikuiui and Pauiaivik lakes of ~9.6 and 8.7 ka, respectively. Organic-rich gyttja from deglaciation until ~5.0 ka in Pauiaivik Lake suggests minimal glacial extent there while slightly elevated MS values from ~9.0 - 7.0 ka in Sikuiui Lake may reflect early Holocene glacial advances. Minerogenic sediment input gradually increases starting at ~5.0 ka in Pauiaivik Lake, which we interpret as the onset of Neoglaciation in the catchment. Furthermore, a distinct episode of enhanced glacial activity from ~4.0 - 2.2 ka in Sikuiui Lake may be correlative to a period of persistent snowline lowering evidenced by radiocarbon dates of ice-killed vegetation from nearby ice cap margins. Results from these lacustrine records and our ice-killed vegetation dataset suggest a middle Holocene onset of Neoglaciation ~5.0 - 4.0 ka in this region. We are supplementing these records with cosmogenic 10Be exposure dating to further constrain the timing of deglaciation. In addition, these sedimentary archives will continue to be compared to radiocarbon dates of ice-killed vegetation along adjacent ice cap margins to determine if times of persistent snowline lowering are correlative to periods of glacier advance.

Time Safety Margin: Theory and Practice

DTIC Science & Technology

2016-09-01

Basic Dive Recovery Terminology The Simplest Definition of TSM: Time Safety Margin is the time to directly travel from the worst-case vector to an...Safety Margin (TSM). TSM is defined as the time in seconds to directly travel from the worst case vector (i.e. worst case combination of parameters...invoked by this AFI, base recovery planning and risk management upon the calculated TSM. TSM is the time in seconds to di- rectly travel from the worst case

Lithosphere structure and subsidence evolution of the conjugate S-African and Argentine margins

NASA Astrophysics Data System (ADS)

Dressel, Ingo; Scheck-Wenderoth, Magdalena; Cacace, Mauro; Götze, Hans-Jürgen; Franke, Dieter

2016-04-01

The bathymetric evolution of the South Atlantic passive continental margins is a matter of debate. Though it is commonly accepted that passive margins experience thermal subsidence as a result of lithospheric cooling as well as load induced subsidence in response to sediment deposition it is disputed if the South Atlantic passive margins were affected by additional processes affecting the subsidence history after continental breakup. We present a subsidence analysis along the SW African margin and offshore Argentina and restore paleobathymetries to assess the subsidence evolution of the margin. These results are discussed with respect to mechanisms behind margin evolution. Therefore, we use available information about the lithosphere-scale present-day structural configuration of these margins as a starting point for the subsidence analysis. A multi 1D backward modelling method is applied to separate individual subsidence components such as the thermal- as well as the load induced subsidence and to restore paleobathymetries for the conjugate margins. The comparison of the restored paleobathymetries shows that the conjugate margins evolve differently: Continuous subsidence is obtained offshore Argentina whereas the subsidence history of the SW African margin is interrupted by phases of uplift. This differing results for both margins correlate also with different structural configurations of the subcrustal mantle. In the light of these results we discuss possible implications for uplift mechanisms.

Automated tracking of lava lake level using thermal images at Kīlauea Volcano, Hawai’i

USGS Publications Warehouse

Patrick, Matthew R.; Swanson, Don; Orr, Tim R.

2016-01-01

Tracking the level of the lava lake in Halema‘uma‘u Crater, at the summit of Kīlauea Volcano, Hawai’i, is an essential part of monitoring the ongoing eruption and forecasting potentially hazardous changes in activity. We describe a simple automated image processing routine that analyzes continuously-acquired thermal images of the lava lake and measures lava level. The method uses three image segmentation approaches, based on edge detection, short-term change analysis, and composite temperature thresholding, to identify and track the lake margin in the images. These relative measurements from the images are periodically calibrated with laser rangefinder measurements to produce real-time estimates of lake elevation. Continuous, automated tracking of the lava level has been an important tool used by the U.S. Geological Survey’s Hawaiian Volcano Observatory since 2012 in real-time operational monitoring of the volcano and its hazard potential.

Edge-driven microplate kinematics

USGS Publications Warehouse

Schouten, Hans; Klitgord, Kim D.; Gallo, David G.

1993-01-01

It is known from plate tectonic reconstructions that oceanic microplates undergo rapid rotation about a vertical axis and that the instantaneous rotation axes describing the microplate's motion relative to the bounding major plates are frequently located close to its margins with those plates, close to the tips of propagating rifts. We propose a class of edge-driven block models to illustrate how slip across the microplate margins, block rotation, and propagation of rifting may be related to the relative motion of the plates on either side. An important feature of these edge-driven models is that the instantaneous rotation axes are always located on the margins between block and two bounding plates. According to those models the pseudofaults or traces of disrupted seafloor resulting from the propagation of rifting between microplate and major plates may be used independently to approximately trace the continuous kinematic evolution of the microplate back in time. Pseudofault geometries and matching rotations of the Easter microplate show that for most of its 5 m.y. history, block rotation could be driven by the drag of the Nazca and Pacific plates on the microplate's edges rather than by a shear flow of mantle underneath.

Deep Stucture of the Northwestern Atlantic Moroccan Margin Studied by OBS and Deep Multichannel Seismic Reflection.

NASA Astrophysics Data System (ADS)

MALOD, J. A.; Réhault, J.; Sahabi, M.; Géli, L.; Matias, L.; Diaz, J.; Zitellini, N.

2001-12-01

The Northwestern Atlantic Moroccan margin, a conjugate of the New Scotland margin, is one of the oldest passive margin of the world. Continental break up occurred at early Liassic time and the deep margin is characterized by a large salt basin. A good knowledge of this basin is of major interest to improve the initial reconstruction between Africa, North America and Iberia (Eurasia). It is also a good opportunity to study a mature passive margin and model its structure and evolution.Moreover, there is a need to assess the geological hazards linked to the neotectonic activity within the Africa-Eurasia plate boundary. These topics have been adressed during the SISMAR cruise carried out from April 9th to May 4th 2001.During this cruise, 3667 km of multichannel seismic reflection (360 channels, 4500 m long streamer, 4800 ci array of air guns) were recorded together with refraction records by means of 48 OBH/OBS drops. Simultaneously, some of the marine profiles have been extended onshore with 16 portable seismic land stations. We present the initial results of this study. Off El Jadida, the Moho and structures within the thinned continental crust are well imaged on both the reflection and refraction records. In the northern area, off Casablanca, we follow the deepening of the moroccan margin beneath the up to 9 sec (twtt) allochtonous series forming a prism at the front the Rif-Betic chain. Sismar cruise has been also the opportunity to record long seismic profiles making the junction between the Portuguese margin and the Moroccan one, and crossing the Iberian-African plate boundary. This allows to observe the continuity of the sedimentary sequence after the end of the large inter-plate motion in Early Cretaceous. In addition to the authors, SISMAR Group includes: AMRHAR Mostafa, BERMUDEZ VASQUEZ Antoni, CAMURRI Francesca, CONTRUCCI Isabelle, CORELA Carlos, DIAZ Jordi, DORVAL Philippe, EL ARCHI Abdelkrim, EL ATTARI Ahmed, GONZALEZ Raquel, HARMEGNIES Francois, JAFFAL Mohamed, KLINGELÖFER Fraucke, LANDURÉ Jean Yves, LEGALL Bernard, MAILLARD-LENOIR Agnès, MARTIN Christophe, MEHDI Khalid, MERCIER Eric, MOULIN Maryline, OUAJHAIN Brahim, PERROT Julie, ROLET Joël, RUELLAN Etienne, TEIXIRA Fernando, TERRINHA Pedro, ZOURARAH Bendehhou.

A Longitudinal View of the Relationship Between Social Marginalization and Obesity

NASA Astrophysics Data System (ADS)

Apolloni, Andrea; Marathe, Achla; Pan, Zhengzheng

We use 3 Waves of the Add Health data collected between 1994 and 2002 to conduct a longitudinal study of the relationship between social marginalization and the weight status of adolescents and young adults. Past studies have shown that overweight and obese children are socially marginalized. This research tests (1) if this is true when we account for the sample size of each group, (2) does this phenomenon hold over time and (3) is it obesity or social marginalization that precedes in time. Our results show that when the sample size for each group is considered, the share of friendship is conforming to the size of the group. This conformity seems to increase over time as the population becomes more obese. Finally, we find that obesity precedes social marginalization which lends credence to the notion that obesity causes social marginalization and not vice versa.

Habitable Zone Evolution

NASA Astrophysics Data System (ADS)

Waltham, D.; Lota, J.

2012-12-01

The location of the habitable zone around a star depends upon stellar luminosity and upon the properties of a potentially habitable planet such as its mass and near-surface volatile inventory. Stellar luminosity generally increases as a star ages whilst planetary properties change through time as a consequence of biological and geological evolution. Hence, the location of the habitable zone changes through time as a result of both stellar evolution and planetary evolution. Using the Earth's Phanerozoic temperature history as a constraint, it is shown that changes in our own habitable zone over the last 540 My have been dominated by planetary evolution rather than solar evolution. Furthermore, sparse data from earlier times suggests that planetary evolution may have dominated habitable zone development throughout our biosphere's history. Hence, the existence of a continuously habitable zone depends upon accidents of complex bio-geochemical evolution more than it does upon relatively simple stellar-evolution. Evolution of the inner margin of the habitable zone through time using three different estimates for climate sensitivity. The dashed line shows a typical predicted evolution assuming this was driven simply by a steady increase in solar luminosity. Solar evolution does not account for the observations. Evolution of the outer margin of the habitable zone through time using three different estimates for climate sensitivity. The dashed line shows a typical predicted evolution assuming this was driven simply by a steady increase in solar luminosity. Solar evolution does not account for the observations.

Devonian brachiopods of southwesternmost laurentia: Biogeographic affinities and tectonic significance

USGS Publications Warehouse

Boucot, A.J.; Poole, F.G.; Amaya-Martinez, R.; Harris, A.G.; Sandberg, C.A.; Page, W.R.

2008-01-01

Three brachiopod faunas discussed herein record different depositional and tectonic settings along the southwestern margin of Laurentia (North America) during Devonian time. Depositional settings include inner continental shelf (Cerros de Los Murcielagos), medial continental shelf (Rancho Placeritos), and offshelf continental rise (Rancho Los Chinos). Ages of Devonian brachiopod faunas include middle Early (Pragian) at Rancho Placeritos in west-central Sonora, late Middle (Givetian) at Cerros de Los Murcielagos in northwestern Sonora, and late Late (Famennian) at Rancho Los Chinos in central Sonora. The brachiopods of these three faunas, as well as the gastropod Orecopia, are easily recognized in outcrop and thus are useful for local and regional correlations. Pragian brachiopods dominated by Acrospirifer and Meristella in the "San Miguel Formation" at Rancho Placeritos represent the widespread Appohimchi Subprovince of eastern and southern Laurentia. Conodonts of the early to middle Pragian sulcatus to kindlei Zones associated with the brachiopods confirm the ages indicated by the brachiopod fauna and provide additional information on the depositional setting of the Devonian strata. Biostratigraphic distribution of the Appohimchi brachiopod fauna indicates continuous Early Devonian shelf deposition along the entire southern margin of Laurentia. The largely emergent southwest-trending Transcontinental arch apparently formed a barrier preventing migration and mixing of many genera and species of brachiopods from the southern shelf of Laurentia in northern Mexico to the western shelf (Cordilleran mio-geocline) in the western United States. Middle Devonian Stringocephalus brachiopods and Late Devonian Orecopia gastropods in the "Los Murcielagos Formation" in northwest Sonora represent the southwest-ernmost occurrence of these genera in North America and date the host rocks as Givetian and Frasnian, respectively. Rhynchonelloid brachiopods (Dzieduszyckia sonora) and associated worm tubes in the Los Pozos Formation of the Sonora allochthon in central Sonora are also found in strati-form-barite facies in the upper Upper Devonian (Famennian) part of the Slaven Chert in the Roberts Mountains allochthon (upper plate) of central and western Nevada. Although these brachiopods and worm tubes occur in similar depositional settings along the margin of Laurentia in Mexico, they occur in allochthons that exhibit different tectonic styles and times of emplacement. Thus, the allochthons containing the brachiopods and worm tubes in Sonora and Nevada are parts of separate orogenic belts and have different geographic settings and tectonic histories. Devonian facies belts and faunas in northern Mexico indicate a continuous continental shelf along the entire southern margin of Laurentia. These data, in addition to the continuity of the late Paleozoic Ouachita-Marathon-Sonora orogen across northern Mexico, contradict the early Late Jurassic Mojave-Sonora megashear as a viable hypothesis for large-magnitude offset (600-1100 km) of Proterozoic through Middle Jurassic rocks from California to Sonora. ?? 2008 The Geological Society of America.

Rapid and continuous magnetic separation in droplet microfluidic devices.

PubMed

Brouzes, Eric; Kruse, Travis; Kimmerling, Robert; Strey, Helmut H

2015-02-07

We present a droplet microfluidic method to extract molecules of interest from a droplet in a rapid and continuous fashion. We accomplish this by first marginalizing functionalized super-paramagnetic beads within the droplet using a magnetic field, and then splitting the droplet into one droplet containing the majority of magnetic beads and one droplet containing the minority fraction. We quantitatively analysed the factors which affect the efficiency of marginalization and droplet splitting to optimize the enrichment of magnetic beads. We first characterized the interplay between the droplet velocity and the strength of the magnetic field and its effect on marginalization. We found that marginalization is optimal at the midline of the magnet and that marginalization is a good predictor of bead enrichment through splitting at low to moderate droplet velocities. Finally, we focused our efforts on manipulating the splitting profile to improve the enrichment provided by asymmetric splitting. We designed asymmetric splitting forks that employ capillary effects to preferentially extract the bead-rich regions of the droplets. Our strategy represents a framework to optimize magnetic bead enrichment methods tailored to the requirements of specific droplet-based applications. We anticipate that our separation technology is well suited for applications in single-cell genomics and proteomics. In particular, our method could be used to separate mRNA bound to poly-dT functionalized magnetic microparticles from single cell lysates to prepare single-cell cDNA libraries.

Rapid and continuous magnetic separation in droplet microfluidic devices

PubMed Central

Brouzes, Eric; Kruse, Travis; Kimmerling, Robert; Strey, Helmut H.

2015-01-01

We present a droplet microfluidic method to extract molecules of interest from a droplet in a rapid and continuous fashion. We accomplish this by first marginalizing functionalized super-paramagnetic beads within the droplet using a magnetic field, and then splitting the droplet into one droplet containing the majority of magnetic beads and one droplet containing the minority fraction. We quantitatively analysed the factors which affect the efficiency of marginalization and droplet splitting to optimize the enrichment of magnetic beads. We first characterized the interplay between the droplet velocity and the strength of the magnetic field and its effect on marginalization. We found that marginalization is optimal at the midline of the magnet and that marginalization is a good predictor of bead enrichment through splitting at low to moderate droplet velocities. Finally, we focused our efforts on manipulating the splitting profile to improve the enrichment provided by asymmetric splitting. We designed asymmetric splitting forks that employ capillary effects to preferentially extract the bead-rich regions of the droplets. Our strategy represents a framework to optimize magnetic bead enrichment methods tailored to the requirements of specific droplet-based applications. We anticipate that our separation technology is well suited for applications in single-cell genomics and proteomics. In particular, our method could be used to separate mRNA bound to poly-dT functionalized magnetic microparticles from single cell lysates to prepare single-cell cDNA libraries. PMID:25501881

Breakup of Pangaea and plate kinematics of the central Atlantic and Atlas regions

NASA Astrophysics Data System (ADS)

Schettino, Antonio; Turco, Eugenio

2009-08-01

A new central Pangaea fit (type A) is proposed for the late Ladinian (230 Ma), together with a plate motions model for the subsequent phases of rifting, continental breakup and initial spreading in the central Atlantic. This model is based on: (1) a reinterpretation of the process of formation of the East Coast Magnetic Anomaly along the eastern margin of North America and the corresponding magnetic anomalies at the conjugate margins of northwest Africa and the Moroccan Meseta; (2) an analysis of major rifting events in the central Atlantic, Atlas and central Mediterranean and (3) a crustal balancing of the stretched margins of North America, Moroccan Meseta and northwest Africa. The process of fragmentation of central Pangaea can be described by three major phases spanning the time interval from the late Ladinian (230 Ma) to the Tithonian (147.7 Ma). During the first phase, from the late Ladinian (230 Ma) to the latest Rhaetian (200 Ma), rifting proceeded along the eastern margin of North America, the northwest African margin and the High, Saharan and Tunisian Atlas, determining the formation of a separate Moroccan microplate at the interface between Gondwana and Laurasia. During the second phase, from the latest Rhaetian (200 Ma) to the late Pliensbachian (185 Ma), oceanic crust started forming between the East Coast and Blake Spur magnetic anomalies, whereas the Morrocan Meseta simply continued to rift away from North America. During this time interval, the Atlas rift reached its maximum extent. Finally, the third phase, encompassing the time interval from the late Pliensbachian (185 Ma) to chron M21 (147.7 Ma), was triggered by the northward jump of the main plate boundary connecting the central Atlantic with the Tethys area. Therefore, as soon as rifting in the Atlas zone ceased, plate motion started along complex fault systems between Morocco and Iberia, whereas a rift/drift transition occurred in the northern segment of the central Atlantic, between Morocco and the conjugate margin of Nova Scotia. The inversion of the Atlas rift and the subsequent formation of the Atlas mountain belt occurred during the Oligocene-early Miocene time interval. In the central Atlantic, this event was associated with higher spreading rates of the ridge segments north of the Atlantis FZ. An estimate of 170 km of dextral offset of Morocco relative to northwest Africa, in the central Atlantic, is required by an analysis of marine magnetic anomalies. Five plate tectonic reconstructions and a computer animation are proposed to illustrate the late Triassic and Jurassic process of breakup of Pangaea in the central Atlantic and Atlas regions.

New Insight Into The Crustal Structure of The Continental Margin Off NW Sabah/borneo

NASA Astrophysics Data System (ADS)

Barckhausen, U.; Franke, D.; Behain, D.; Meyer, H.

The continental margin offshore NW Sabah/Borneo (Malaysia) has been investigated with reflection and refraction seismics, magnetics, and gravity during the recent cruise BGR01-POPSCOMS. A total of 4000 km of geophysical profiles has been acquired, thereof 2900 km with reflection seismics. Like in major parts of the South China Sea, the area seaward of the Sabah Trough consists of extended continental lithosphere. We found evidence that the continental crust also underlies the continental slope land- ward of the Trough, a fact that raises many questions about the tectonic history and development of this margin. The characteristic pattern of rotated fault blocks and half grabens and the carbon- ates which are observed all over the Dangerous Grounds can be traced a long way landward of the Sabah Trough beneath the sedimentary succession of the upper plate. The magnetic anomalies which are dominated by the magnetic signatures of relatively young volcanic features also continue under the continental slope. The sedimentary rocks of the upper plate, in contrast, seem to generate hardly any magnetic anoma- lies. We suspect that the volcanic activity coincided with the collision of Borneo and the Dangerous Grounds in middle or late Miocene time. The emplacement of an al- lochtonous terrane on top of the extended continental lithosphere could be explained by overthrusting as a result of the collision or it could be related to gravity sliding following a broad uplift of NW Borneo at the same time.

Advancing land-terminating ice margin in North Greenland - characteristics, evolution, and first field measurements

NASA Astrophysics Data System (ADS)

Steiner, J. F.; Prinz, R.; Abermann, J.

2017-12-01

More than 40% of the ice sheet in North Greenland terminate on land, however the characteristics of this ice margin and response to a changing climate have so far received little attention. While land-terminating ice cliffs are a feature commonly found and studied in other regions, detailed investigations in Greenland were only carried out more than six decades ago in the Thule area (Red Rock, Northwest Greenland). These studies showed a continuous advance at one location over multiple years, while the local mass balance was reported negative. The purpose of our study is to revisit the location previously studied and extend the analysis to the complete Northern ice margin employing newly available high-resolution digital terrain models (Arctic DEM). First results show that the advance at Red Rock is indeed long-term, continuing unabated today at rates of up to several meter per year. Similar magnitudes were found for large other stretches along the ice margin. With our study we aim to show (a) the main characteristics of the land-terminating ice margin in Northern Greenland, namely its slope and aspect distribution and comparison to spatial datasets of flow velocity and mass balance and (b) to provide further explanations of physical processes driving the advance. We have therefore mapped the complete ice margin and present the first results of this analysis. First field work provides new data on energy fluxes and ice temperatures at the Red Rock site as well as high resolution DEMs obtained with the use of UAVs.

The South China sea margins: Implications for rifting contrasts

USGS Publications Warehouse

Hayes, D.E.; Nissen, S.S.

2005-01-01

Implications regarding spatially complex continental rifting, crustal extension, and the subsequent evolution to seafloor spreading are re-examined for the northern and southern-rifted margins of the South China Sea. Previous seismic studies have shown dramatic differences in the present-day crustal thicknesses as the manifestations of the strain experienced during the rifting of the margin of south China. Although the total crustal extension is presumed to be the same along the margin and adjacent ocean basin, the amount of continental crustal extension that occurred is much less along the east and central segments of the margin than along the western segment. This difference was accommodated by the early formation of oceanic crust (creating the present-day South China Sea basin) adjacent to the eastern margin segment while continued extension of continental crust was sustained to the west. Using the observed cross-sectional areas of extended continental crust derived from deep penetration seismics, two end-member models of varying rift zone widths and varying initial crustal thicknesses are qualitatively examined for three transects. Each model implies a time difference in the initiation of seafloor spreading inferred for different segments along the margin. The two models examined predict that the oceanic crust of the South China Sea basin toward the west did not begin forming until sometime between 6-12 my after its initial formation (???32 Ma) toward the east. These results are compatible with crustal age interpretations of marine magnetic anomalies. Assuming rifting symmetry with conjugate margin segments now residing along the southern portions of the South China Sea basin implies that the total width of the zone of rifting in the west was greater than in the east by about a factor of two. We suggest the most likely causes of the rifting differences were east-west variations in the rheology of the pre-rift crust and associated east-west variations in the thermal structure of the pre-rift lithosphere. The calculated widths of rifted continental crust for the northern and southern margins, when combined with the differential widths of seafloor generated during the seafloor spreading phase, indicate the total crustal extension that occurred is about 1100 km and is remarkably consistent to within ???10% for all three (eastern, central, western) segments examined. ?? 2005 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Everett, J.R.; Russell, O.R.; Staskowski, R.J.

Analysis of 38 contiguous Landsat Multispectral Scanner scenes acquired over Myanmar (Burma) reveals numerous large-scale features associated with margins of the Burman plate, previously unidentified northeast-southwest-trending discontinuities, important extensions of previously mapped fault trends, and numerous structural features that appear favorable for petroleum exploration. A mosaic of these scenes at 1:1,000,000 scale shows a large number of tectonic elements and their spatial relationships. Within the area of investigation are portions of the Indian, Burman, Lhasa, and Shan-Thai plates, and perhaps other, smaller plates. The Himalayan front and Indo-Burman Ranges manifest effects of current and recently past plate movement. The complexitymore » of the kinematic history accounts for the diversity of structural features in the area. The last major event in this long and violent saga, which began in middle Miocene (approximately 11 Ma) time and continues to the present, is the recent change from a collisional to a right-lateral strike-slip transform margin between the Indian and Burman plates. The complexity of the structures visible is the product of multiple plate collisions, rotation of the Indian plate and parts of the Asian plate, and long-continued convergence that changed velocity and direction tbrough time. The most obvious evidence of this complexity, which is immediately apparent on geologic maps or the Landsat mosaic of the region, is the almost right-angle relationship of the folds of the Indo-Burman Ranges and the frontal thrusts and suture zones of the Himalaya. These two sets of compressive features imply maximum compressive stress axes that lie at right angles to each other. The implications are either that the orientation of the stress field changes rapidly over a short distance or that the stress field has changed through time. Both occurrences seem to be true.« less

An integrated geophysical study on the Mesozoic strata distribution and hydrocarbon potential in the South China Sea

NASA Astrophysics Data System (ADS)

Hu, Weijian; Hao, Tianyao; Jiang, Weiwei; Xu, Ya; Zhao, Baimin; Jiang, Didi

2015-11-01

A series of drilling, dredge, and seismic investigations indicate that Mesozoic sediments exist in the South China Sea (SCS) which shows a bright prospect for oil and gas exploration. In order to study the distribution of Mesozoic strata and their residual thicknesses in the SCS, we carried out an integrated geophysical study based mainly on gravity data, gravity basement depth and distribution of residual Mesozoic thickness in the SCS were obtained using gravity inversion constrained with high-precision drilling and seismic data. In addition, the fine deep crustal structures and distribution characteristics of Mesozoic thicknesses of three typical profiles were obtained by gravity fitting inversion. Mesozoic strata in the SCS are mainly distributed in the south and north continental margins, and have been reformed by the later tectonic activities. They extend in NE-trending stripes are macro-controlled by the deep and large NE-trending faults, and cut by the NW-trending faults which were active in later times. The offset in NW direction of Mesozoic strata in Nansha area of the southern margin are more obvious as compared to the north margin. In the Pearl River Mouth Basin and Southwest Taiwan Basin of the north continental margin the Mesozoic sediments are continuously distributed with a relatively large thickness. In the Nansha area of the south margin the Mesozoic strata are discontinuous and their thicknesses vary considerably. According to the characteristics of Mesozoic thickness distribution and hydrocarbon potential analyses from drilling and other data, Dongsha Uplift-Chaoshan Depression, Southwest Taiwan Basin-Peikang Uplift and Liyue Bank have large thickness of the Mesozoic residual strata, have good hydrocarbon genesis capability and complete source-reservoir-cap combinations, show a bright prospect of Mesozoic oil/gas resources.

Length of positive surgical margin after radical prostatectomy as a predictor of biochemical recurrence.

PubMed

Shikanov, Sergey; Song, Jie; Royce, Cassandra; Al-Ahmadie, Hikmat; Zorn, Kevin; Steinberg, Gary; Zagaja, Gregory; Shalhav, Arieh; Eggener, Scott

2009-07-01

Length and location of positive surgical margins are independent predictors of biochemical recurrence after open radical prostatectomy. We assessed their impact on biochemical recurrence in a large robotic prostatectomy series. Data were collected prospectively from 1,398 men undergoing robotic radical prostatectomy for clinically localized prostate cancer from 2003 to 2008 at a single institution. The associations of preoperative prostate specific antigen, pathological Gleason score, pathological stage and positive surgical margin parameters (location, length and focality) with biochemical recurrence rate were evaluated. Margin status and length were measured by a single uropathologist. Biochemical recurrence was defined as serum prostate specific antigen greater than 0.1 ng/ml on 2 consecutive tests. Cox regression models were constructed to evaluate predictors of biochemical recurrence. Of 1,398 consecutive patients who underwent robotic prostatectomy positive margins were present in 243 (17%) (11% of pathological T2 and 41% of T3). Preoperative prostate specific antigen, pathological stage, Gleason score, margin status, and margin length as a continuous and categorical variable (less than 1, 1 to 3, more than 3 mm) were independent predictors of biochemical recurrence. Patients with negative margins and those with a positive margin less than 1 mm had similar rates of biochemical recurrence (log rank test p = 0.18). Surgical margin location was not independently associated with biochemical recurrence. Margin status and length are independent predictors of biochemical recurrence following robotic radical prostatectomy. Although longer followup and validation studies are necessary for confirmation, patients with a positive margin less than 1 mm appear to have similar recurrence rates as those with negative margins.

The Effect of Sintering Time on the Marginal Fit of Zirconia Copings.

PubMed

Khaledi, Amir Ali Reza; Vojdani, Mahroo; Farzin, Mitra; Pirouzi, Sudabeh; Orandi, Sepideh

2018-01-03

This study analyzed the effect of different sintering times on the marginal adaptation of zirconia ceramic copings. Thirty copings of pre-sintered 3Y-TZP blanks were milled and subsequently sintered in a special furnace for three different durations (n = 10 per group). The sintering time was 1 hour, 15 minutes for IPS e.max ZirCAD, 4 hours 20 minutes for Speed ZrO 2, and 7 hours 20 minutes for the conventional ZrO 2 group. The marginal gaps of specimens were measured at 18 spots on the master die by employing a digital microscope. One-way ANOVA test compared the mean differences among the 3 groups (α = 0.05). The mean values for the marginal gap of the IPS e.max ZirCAD, Speed ZrO 2 , and conventional ZrO 2 groups were 41.06 ± 14.03, 43.03 ± 11.67, and 39.88 ± 15.23 μm, respectively. There was no statistically significant difference among the groups regarding the marginal gap. Different sintering times did not alter the marginal fit of the zirconia copings. The mean values of the marginal gap were within the clinically acceptable level for all three groups. © 2018 by the American College of Prosthodontists.

Mass spectrometry in the palm of your hand: future applications of in vivo tissue analysis.

PubMed

Fox, Simon A; Farah, Camile S

2018-05-21

Assessment and diagnosis of oral mucosal disorders continues to present clinical challenges with conventional methodologies being time consuming and hampered by subjectivity. These considerations also apply to surgical excision of malignant and potentially malignant lesions where accurate assessment of margins is critical to patient outcomes. These clinical needs are driving the development of new technologies which can enable rapid diagnosis based upon characteristic molecular profiles identified through clinical science. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Intraoperative ultrasound control of surgical margins during partial nephrectomy.

PubMed

Alharbi, Feras M; Chahwan, Charles K; Le Gal, Sophie G; Guleryuz, Kerem M; Tillou, Xavier P; Doerfler, Arnaud P

2016-01-01

To evaluate a simple and fast technique to ensure negative surgical margins on partial nephrectomies, while correlating margin statuses with the final pathology report. This study was conducted for patients undergoing partial nephrectomy (PN) with T1-T2 renal tumors from January 2010 to the end of December 2015. Before tumor removal, intraoperative ultrasound (US) localization was performed. After tumor removal and before performing hemostasis of the kidney, the specimens were placed in a saline solution and a US was performed to evaluate if the tumor's capsule were intact, and then compared to the final pathology results. In 177 PN(s) (147 open procedures and 30 laparoscopic procedures) were performed on 147 patients. Arterial clamping was done for 32 patients and the mean warm ischemia time was 19 ± 6 min. The mean US examination time was 41 ± 7 s. The US analysis of surgical margins was negative in 172 cases, positive in four, and in only one case it was not possible to conclude. The final pathology results revealed one false positive surgical margin and one false negative surgical margin, while all other margins were in concert with US results. The mean tumor size was 3.53 ± 1.43 cm, and the mean surgical margin was 2.8 ± 1.5 mm. The intraoperative US control of resection margins in PN is a simple, efficient, and effective method for ensuring negative surgical margins with a small increase in warm ischemia time and can be conducted by the operating urologist.

A quantitative comparison of the safety margins in the european indicative occupational exposure limits and the derived no-effect levels for workers under REACH.

PubMed

Schenk, Linda; Johanson, Gunnar

2011-06-01

The new European Union (EU) REACH legislation requires derived no-effect levels (DNELs) to be calculated for substances produced in quantities above 10 tonnes/year. Meanwhile, the setting of occupational exposure limits (OELs) continues both at the member state and the EU levels. According to REACH, indicative OEL values (IOELVs) from the Commission may under some circumstances be used as worker-DNELs. On the other hand, worker-DNELs will be derived for several thousand substances, far more than the approximately 100 substances for which IOELVs have been established. Thus, the procedure to set health-based OELs may become influential on that of DNELs and vice versa. In this study, we compare the safety margins of 88 Scientific Committee on OELs (SCOEL) recommendations with those of the corresponding worker-DNELs, derived according to the default approach as described in the REACH guidance document. Overall, the REACH safety margins were approximately six times higher than those derived from the SCOEL documentation but varied widely with REACH/SCOEL safety margin ratios ranging by two orders of magnitude, from 0.3 to 58 (n = 88). The discrepancies may create confusion in terms of legal compliance, risk management, and risk communication. We also found that the REACH guidance document, although encompassing detailed advice on many issues, including default assessment factors for species and route extrapolation, gives little quantitative guidance on when and how to depart from defaults.

Safety margins in older adults increase with improved control of a dynamic object

PubMed Central

Hasson, Christopher J.; Sternad, Dagmar

2014-01-01

Older adults face decreasing motor capabilities due to pervasive neuromuscular degradations. As a consequence, errors in movement control increase. Thus, older individuals should maintain larger safety margins than younger adults. While this has been shown for object manipulation tasks, several reports on whole-body activities, such as posture and locomotion, demonstrate age-related reductions in safety margins. This is despite increased costs for control errors, such as a fall. We posit that this paradox could be explained by the dynamic challenge presented by the body or also an external object, and that age-related reductions in safety margins are in part due to a decreased ability to control dynamics. To test this conjecture we used a virtual ball-in-cup task that had challenging dynamics, yet afforded an explicit rendering of the physics and safety margin. The hypotheses were: (1) When manipulating an object with challenging dynamics, older adults have smaller safety margins than younger adults. (2) Older adults increase their safety margins with practice. Nine young and 10 healthy older adults practiced moving the virtual ball-in-cup to a target location in exactly 2 s. The accuracy and precision of the timing error quantified skill, and the ball energy relative to an escape threshold quantified the safety margin. Compared to the young adults, older adults had increased timing errors, greater variability, and decreased safety margins. With practice, both young and older adults improved their ability to control the object with decreased timing errors and variability, and increased their safety margins. These results suggest that safety margins are related to the ability to control dynamics, and may explain why in tasks with simple dynamics older adults use adequate safety margins, but in more complex tasks, safety margins may be inadequate. Further, the results indicate that task-specific training may improve safety margins in older adults. PMID:25071566

Syn- and post-rift anomalous vertical movements in the eastern Central Atlantic passive margin: a transect across the Moroccan passive continental margin.

NASA Astrophysics Data System (ADS)

Charton, Remi; Bertotti, Giovanni; Arantegui, Angel; Luber, Tim; Redfern, Jonathan

2017-04-01

Traditional models of passive margin evolution suggesting generalised regional subsidence with rates decreasing after the break-up have been questioned in the last decade by a number of detailed studies. The occurrence of episodic km-scale exhumation well within the post-rift stage, possibly associated with significant erosion, have been documented along the Atlantic continental margins. Despite the wide-spread and increasing body of evidence supporting post-rift exhumation, there is still limited understanding of the mechanism or scale of these phenomena. Most of these enigmatic vertical movements have been discovered using low-temperature geochronology and time-temperature modelling along strike of passive margins. As proposed in previous work, anomalous upward movements in the exhuming domain are coeval with higher-than-normal downward movements in the subsiding domain. These observations call for an integrated analysis of the entire source-to-sink system as a pre-requisite for a full understanding of the involved tectonics. We reconstruct the geological evolution of a 50km long transect across the Moroccan passive margin from the Western Anti-Atlas (Ifni area) to the offshore passive margin basin. Extending the presently available low-temperature geochronology database and using a new stratigraphic control of the Mesozoic sediments, we present a reconstruction of vertical movements in the area. Further, we integrate this with the analysis of an offshore seismic line and the pattern of vertical movements in the Anti-Atlas as documented in Gouiza et al. (2016). The results based on sampled rocks indicate exhumation by circa 6km after the Variscan orogeny until the Middle Jurassic. During the Late Jurassic to Early Cretaceous the region was subsequently buried by 1-2km, and later exhumed by 1-2km from late Early/Late Cretaceous onwards. From the Permian to present day, the Ifni region is the link between the generally exhuming Anti Atlas and continually subsiding offshore basins. Along strike, the rifted margin exhibits significant variability in the architecture of the Mesozoic deposits onshore and present day offshore shelf. North of the High Atlas, the ca. 2km thick Mesozoic succession is characterized by continuous sedimentation. South of the High Atlas the thickness increases to 6km in the offshore Tarfaya basin, where the Jurassic succession may be separated by a regional unconformity. Further south, close to the border with Mauritania, the Triassic to Jurassic succession is missing and the Cretaceous attains less than a kilometre of strata. In the Meseta and High Atlas, studies documented a similar kinematic Mesozoic evolution, whereas in the Anti-Atlas Gouiza et al. (2016) and this study document a different evolution. In addition, the kinematic evolution of the Reguibate domain to the south is also different from the other segments, showing post-Variscan exhumation with amplitudes lower than the ones observed in the Anti-Atlas. These observations highlight changes in the pattern of enigmatic movements along the same passive continental margin thereby showing that passive continental margins are more complex than expected only a few years ago. Gouiza, M., Charton, R., Bertotti, G., Andriessen, P. and Storms, J.E.A., 2016. Post-Variscan evolution of the Anti-Atlas belt of Morocco constrained from low-temperature geochronology: International Journal of Earth Sciences.

US refining margin trend: austerity continues

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Should crude oil prices hold near current levels in 1988, US refining margins might improve little, if at all. If crude oil prices rise, margins could blush pink or worse. If they drop, US refiners would still probably not see much margin improvement. In fact, if crude prices fall, they could set off another free fall in products markets and threaten refiner survival. Volatility in refined products markets and low product demand growth are the underlying reasons for caution or pessimism as the new year approaches. Recent directional patterns in refining margins are scrutinized in this issue. This issue alsomore » contains the following: (1) the ED refining netback data for the US Gulf and West Coasts, Rotterdam, and Singapore for late November, 1987; and (2) the ED fuel price/tax series for countries of the Eastern Hemisphere, November, 1987 edition. 4 figures, 6 tables.« less

Comparison of marginal accuracy of castings fabricated by conventional casting technique and accelerated casting technique: an in vitro study.

PubMed

Reddy, S Srikanth; Revathi, Kakkirala; Reddy, S Kranthikumar

2013-01-01

Conventional casting technique is time consuming when compared to accelerated casting technique. In this study, marginal accuracy of castings fabricated using accelerated and conventional casting technique was compared. 20 wax patterns were fabricated and the marginal discrepancy between the die and patterns were measured using Optical stereomicroscope. Ten wax patterns were used for Conventional casting and the rest for Accelerated casting. A Nickel-Chromium alloy was used for the casting. The castings were measured for marginal discrepancies and compared. Castings fabricated using Conventional casting technique showed less vertical marginal discrepancy than the castings fabricated by Accelerated casting technique. The values were statistically highly significant. Conventional casting technique produced better marginal accuracy when compared to Accelerated casting. The vertical marginal discrepancy produced by the Accelerated casting technique was well within the maximum clinical tolerance limits. Accelerated casting technique can be used to save lab time to fabricate clinical crowns with acceptable vertical marginal discrepancy.

Adult Continuing Education in Small States and Islands: Concept Paper.

ERIC Educational Resources Information Center

Rogers, Alan

1996-01-01

Small states and islands have strengths and weaknesses that affect adult continuing education: marginalization and threats to their legitimacy from economic globalization; educational globalization, with increasing credentialism and sectoralization; and limited resources for technology and teacher development. (SK)

Association Between Peri-implant Bone Morphology and Marginal Bone Loss: A Retrospective Study on Implant-Supported Mandibular Overdentures.

PubMed

Ding, Qian; Zhang, Lei; Geraets, Wil; Wu, Wuqing; Zhou, Yongsheng; Wismeijer, Daniel; Xie, Qiufei

The present study aimed to explore the association between marginal bone loss and type of peri-implant bony defect determined using a new peri-implant bony defect classification system. A total of 110 patients with implant-supported mandibular overdentures were involved. Clinical information was collected, including gender, age, smoking habit, and the overdenture attachment system used. Peri-implant bony defect types and marginal distances (ie, distance between the marginal bone level and the top of the implant shoulder) of all sites were identified on panoramic radiographs by a single experienced observer. The associations between marginal distance and peri-implant bony defect type, gender, age, smoking habit, attachment system, and time after implantation were investigated using marginal generalized linear models and regression analysis. A total of 83 participants were included in the final sample with a total of 224 implants involving 3,124 implant sites. The mean observation time was 10.7 years. All peri-implant bony defect types except Type 5 (slit-like) were significantly related to marginal distance in all models (P < .01). Smoking and time after implantation were significantly related to marginal distance while gender, age, and the overdenture attachment system used were not. The peri-implant bony defect type, determined using the new classification system, is associated with the extent of marginal bone loss.

The Thermal Evolution of the Southeast Baffin Island Continental Margin: An Integrated Apatite Fission Track and Apatite (U-Th)/He Study

NASA Astrophysics Data System (ADS)

Jess, S.; Stephenson, R.; Brown, R. W.

2017-12-01

The elevated continental margins of the North Atlantic continue to be a focus of considerable geological and geomorphological debate, as the timing of major tectonic events and the age of topographic relief remain controversial. The West Greenland margin, on the eastern flank of Baffin Bay, is believed by some authors to have experienced tectonic rejuvenation and uplift during the Neogene. However, the opposing flank, Baffin Island, is considered to have experienced a protracted erosional regime with little tectonic activity since the Cretaceous. This work examines the thermal evolution of the Cumberland Peninsula, SE Baffin Island, using published apatite fission track (AFT) data with the addition of 103 apatite (U-Th)/He (AHe) ages. This expansion of available thermochronological data introduces a higher resolution of thermal modelling, whilst the application of the newly developed `Broken Crystals' technique provides a greater number of thermal constraints for an area dominated by AHe age dispersion. Results of joint thermal modelling of the AFT and AHe data exhibit two significant periods of cooling across the Cumberland Peninsula: Devonian/Carboniferous to the Triassic and Late Cretaceous to present. The earliest phase of cooling is interpreted as the result of major fluvial systems present throughout the Paleozoic that flowed across the Canadian Shield to basins in the north and south. The later stage of cooling is believed to result from rift controlled fluvial systems that flowed into Baffin Bay during the Mesozoic and Cenozoic during the early stages and culmination of rifting along the Labrador-Baffin margins. Glaciation in the Late Cenozoic has likely overprinted these later river systems creating a complex fjordal distribution that has shaped the modern elevated topography. This work demonstrates how surface processes, and not tectonism, can explain the formation of elevated continental margins and that recent methodological developments in the field of low temperature thermochronology are improving our understanding of onshore passive margin development.

Recent sediment transport and deposition in the Cap-Ferret Canyon, South-East margin of Bay of Biscay

NASA Astrophysics Data System (ADS)

Schmidt, Sabine; Howa, Hélène; Diallo, Amy; Martín, Jacobo; Cremer, Michel; Duros, Pauline; Fontanier, Christophe; Deflandre, Bruno; Metzger, Edouard; Mulder, Thierry

2014-06-01

The Cap-Ferret Canyon (CFC), a major morphologic feature of the eastern margin of the Bay of Biscay, occupies a deep structural depression that opens about 60 km southwest of the Gironde Estuary. Detailed depth profiles of the particle-reactive radionuclides 234Th and 210Pb in interface sediments were used to characterise the present sedimentation (bioturbation, sediment mass accumulation, and focusing) in the CFC region. Two bathymetric transects were sampled along the CFC axis and the southern adjacent margin. Particle fluxes were recorded from the nearby Landes Plateau by means of sediment traps in 2006 and 2007. This dataset provides a new and comprehensive view of particulate matter transfer in the Cap-Ferret Canyon region, through a direct comparison of the canyon with the adjacent southern margin. Radionuclide profiles (234Th and 210Pb) and mass fluxes demonstrate that significant particle dynamics occur on the SE Aquitanian margin in comparison with nearby margins. The results also suggest show three distinct areas in terms of sedimentary activity. In the upper canyon (<500 m), there is little net sediment accumulation, suggesting a by-pass area. Sediment focusing is apparent at the middle canyon (500-1500 m), that therefore acts as a depocenter for particles from the shelf and the upper canyon. The lower canyon (>2000 m) can be considered inactive at annual or decadal scales. In contrast with the slow and continuous accumulation of relatively fresh material that characterises the middle canyon, the lower canyon receives pulses of sediment via gravity flows on longer time scales. At decadal scale, the CFC can be considered as a relatively quiescent canyon. The disconnection of the CFC from major sources of sediment delivery seems to limit its efficiency in particle transfer from coastal areas to the adjacent ocean basin.

Local adaptations to frost in marginal and central populations of the dominant forest tree Fagus sylvatica L. as affected by temperature and extreme drought in common garden experiments.

PubMed

Kreyling, Juergen; Buhk, Constanze; Backhaus, Sabrina; Hallinger, Martin; Huber, Gerhard; Huber, Lukas; Jentsch, Anke; Konnert, Monika; Thiel, Daniel; Wilmking, Martin; Beierkuhnlein, Carl

2014-03-01

Local adaptations to environmental conditions are of high ecological importance as they determine distribution ranges and likely affect species responses to climate change. Increased environmental stress (warming, extreme drought) due to climate change in combination with decreased genetic mixing due to isolation may lead to stronger local adaptations of geographically marginal than central populations. We experimentally observed local adaptations of three marginal and four central populations of Fagus sylvaticaL., the dominant native forest tree, to frost over winter and in spring (late frost). We determined frost hardiness of buds and roots by the relative electrolyte leakage in two common garden experiments. The experiment at the cold site included a continuous warming treatment; the experiment at the warm site included a preceding summer drought manipulation. In both experiments, we found evidence for local adaptation to frost, with stronger signs of local adaptation in marginal populations. Winter frost killed many of the potted individuals at the cold site, with higher survival in the warming treatment and in those populations originating from colder environments. However, we found no difference in winter frost tolerance of buds among populations, implying that bud survival was not the main cue for mortality. Bud late frost tolerance in April differed between populations at the warm site, mainly because of phenological differences in bud break. Increased spring frost tolerance of plants which had experienced drought stress in the preceding summer could also be explained by shifts in phenology. Stronger local adaptations to climate in geographically marginal than central populations imply the potential for adaptation to climate at range edges. In times of climate change, however, it needs to be tested whether locally adapted populations at range margins can successfully adapt further to changing conditions.

Dynamic topography of the southern Central Anatolian Plateau, Turkey, and geodynamic driving mechanisms

NASA Astrophysics Data System (ADS)

Schildgen, T. F.; Cosentino, D.; Dudas, F. O.; Niedermann, S.; Strecker, M. R.; Echler, H.; Yildirim, C.

2010-12-01

Collision between Eurasia and Arabia and subsequent westward extrusion of the Anatolian microplate explains the development of major intracontinental fault systems in Anatolia that have remained active to the present-day. Concurrent, and probable episodic uplift of the Central and Eastern Anatolian plateaus (CAP and EAP), however, suggests that additional geodynamic mechanisms have contributed to the late Cenozoic morphologic development of the region. Sedimentary basins spanning the southern margin of the CAP provide insights on the timing and rates of different phases of surface uplift, giving constraints to test which geodynamic processes have contributed to surface uplift, orogenic plateau growth, and coupled landscape/climate evolution. Stratigraphic and geomorphic records of uplift and subsidence in the Mut Basin at the southern CAP margin and along the Göksu River record dynamic topographic development. Biostratigraphy and Sr isotope stratigraphy on the highest (ca. 2 km) uplifted marine sediments of the Mut basin furnish a maximum age of ca. 8 Ma for the onset of late Cenozoic uplift of the region. A Pliocene to early Pleistocene marine section, inset within the older stratigraphy at ca. 0.2 to 1.2 km elevation, reveals a history of subsidence and renewed uplift, following the initial uplift that occurred between ca. 8 Ma and Pliocene time. The most recent phase of uplift continued with possibly minor interruptions during the Quaternary, and is recorded by a series of fluvial terraces preserved between 30 and 143 m above the modern Göksu River. One terrace (143 m) reveals a 21Ne model exposure age of ca. 160 ka; ongoing exposure age determination will further constrain the uplift history. Different geodynamic mechanisms have likely contributed to surface uplift along the southern CAP margin. Initial uplift may have been associated with the predominantly sinistral Ecemis fault system that spans the southern and southeastern CAP margin. Neogene counter-clockwise rotation of Central Anatolia and changes in regional fault kinematics, which likely caused local compression along structures with previous sinistral strike-slip kinematics, may have contributed to early deformation and uplift of the region. Our stratigraphic and field data, together with regional geophysical anomalies, suggest that more recent uplift may be related to upwelling asthenosphere through a slab window, which formed when the initial slab detachment associated with the Bitlis-Zagros collision zone (southern margin of the EAP) propagated to the southwest. The intervening Pliocene to early Pleistocene subsidence was likely related to E-W stretching of the southern margin, possibly driven by oroclinal bending of the margin.

Long-Term Geochemical and Geodynamic Segmentation of the Paleo-Pacific Margin of Gondwana: Insight From the Antarctic and Adjacent Sectors

NASA Astrophysics Data System (ADS)

Nelson, D. A.; Cottle, J. M.

2017-12-01

Combined zircon geochemistry and geochronology of Mesozoic volcaniclastic sediments of the central Transantarctic Mountains, Antarctica, yield a comprehensive record of both the timing and geochemical evolution of the magmatic arc along the Antarctic sector of the paleo-Pacific margin of Gondwana. Zircon age populations at 266-183 Ma, 367-328 Ma, and 550-490 Ma correspond to episodic arc activity from the Ediacaran to the Jurassic. Zircon trace element geochemistry indicates a temporal shift from granitoid-dominated source(s) during Ediacaran to Early Ordovician times to mafic sources in the Devonian through Early Jurassic. Zircon initial ɛHf shifts to more radiogenic Hf isotope compositions following the Ross Orogeny and is inferred to reflect juvenile crustal growth within an extensional arc system during progressive slab rollback. These new ages and Hf isotopic record are similar to those from the Australian sector, indicating that these regions constituted an 3,000 km laterally continuous extensional arc from at least the Carboniferous to the Permian. Conversely, the South American sector records enriched zircon Hf isotopic compositions and compressional/advancing arc tectonics during the same time period. Our new data constrain the location of this profound along-arc geochemical and geodynamic "switch" to the vicinity of the Thurston Island block of West Antarctica.

Exploring local borders of distribution in the shrub Daphne laureola: Individual and populations traits

NASA Astrophysics Data System (ADS)

Castilla, Antonio R.; Alonso, Conchita; Herrera, Carlos M.

2011-05-01

Biogeographic models predict that marginal populations should be more geographically isolated and smaller than central populations, linked to more stressful conditions and likely also to a reduction in density of individuals, individual growth, survival and reproductive output. This variation in population features could have important consequences for different aspects of plant ecology such as individual reproductive success, population genetic structure or plant-animal interactions. In this study, we analyze if individuals of the evergreen shrub Daphne laureola at disjunt populations in a local border of its distribution area in southern Iberian Peninsula differ in individual size, shoot growth, reproductive output and the pollination environment from central continuous populations within the area. Plants of central continuous populations were larger and produced more flowers and fruits than plants of marginal disjunct populations suggesting more optimal conditions, although they had lower annual shoot growth. In contrast, fruit set was higher in plants at the local border, suggesting a more efficient pollinator service in these populations where the main pollinator in central continuous populations, the pollen beetle Meligethes elongatus, was not present. Our results do not support strong differences in the ecological stress between marginal disjunct and central continuous populations of D. laureola in the south of the Iberian Peninsula but indicate some changes in plant-pollinator interactions that could be relevant for the sexual polymorphism in this gynodioecious species.

Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer

NASA Astrophysics Data System (ADS)

Nguyen, Freddy T.; Zysk, Adam M.; Kotynek, Jan G.; Bellafiore, Frank J.; Rowland, Kendrith M.; Johnson, Patricia A.; Chaney, J. Eric; Boppart, Stephen A.

2007-02-01

Breast cancer continues to be one of the most widely diagnosed forms of cancer amongst women and the second leading type of cancer deaths amongst women. The recurrence rate of breast cancer is highly dependent on several factors including the complete removal of the primary tumor and the presence of cancer cells in involved lymph nodes. The metastatic spread and staging of breast cancer is also evaluated through the nodal assessment of the regional lymphatic system. A portable real-time spectral domain optical coherence tomography system is being presented as a clinical diagnostic tool in the intraoperative delineation of tumor margins as well as for real time lymph node assessment. The system employs a super luminescent diode centered at 1310 nm with a bandwidth of 92 nm. Using a spectral domain detection system, the data is acquired at a rate of 5 KHz / axial scan. The sample arm is a galvanometer scanning telecentric probe with an objective lens (f = 60 mm, confocal parameter = 1.5 mm) yielding an axial resolution of 8.3 μm and a transverse resolution of 35.0 μm. Images of tumor margins are acquired in the operating room ex vivo on freshly excised human tissue specimen. This data shows the potential of the use of OCT in defining the structural tumor margins in breast cancer. Images taken from ex-vivo samples on the bench system clearly delineate the differences between clusters of tumor cells and nearby adipose cells. In addition, the data shows the potential for OCT as a diagnostic tool in the staging of cancer metastasis through locoregional lymph node assessment.

The financial experience of hospitals with HMO contracts: evidence from Florida.

PubMed

Young, Gary J; Burgess, James F; Desai, Kamal R; Valley, Danielle

2002-01-01

In this paper, we report results from the first study to systematically examine trends in the financial experience of hospitals with health maintenance organization (HMO) contracts. The longitudinal analysis (1990 through 1997) focused on hospitals in Florida. Hospital operating margins for HMO contracts grew tighter toward the end of the study period when the median margin was less than 1%. Teaching hospitals had operating margins that on average were below that of their nonteaching counterparts. The continued growth of HMOs and other managed care entities may have important implications for the future financial viability of U.S. hospitals.

Late Palaeozoic-Cenozoic assembly of the Tethyan orogen in the light of evidence from Greece and Albania

NASA Astrophysics Data System (ADS)

Robertson, A. H. F.

2012-04-01

The objective here is to use the geology and tectonics of a critical part of the Tethyan orogen, represented by Greece and Albania, to shed light on the tectonic development of Tethys on a regional, to global scale, particularly the history of convergence during Late Palaeozoic to Cenozoic time. For Carboniferous time much evidence suggests that the Korabi-Pelagonian crustal unit as exposed in Albania and Greece formed above a northward-dipping subduction zone along the Eurasia continental margin, with Palaeotethys to the south. However, there is also some evidence of southward subduction beneath Gondwana especially from southern Greece and central southern Turkey. Palaeotethys is inferred to have closed in Europe as far to the east as the longitude of Libya, while remaining open beyond this. There is still uncertainty about the Pangea A-type reconstruction that would restore all of the present units in the area to within the E Mediterranean region, versus the Pangea B-type reconstruction that would require right-lateral displacement of exotic terranes, by up to 3,500 km eastwards. In either reconstruction, fragments of the Variscan collisional orogen are likely to have been displaced eastwards (variable distances) in the Balkan region prior to Late Permian-Early Triassic time. From ~Late Permian, the Greece-Albania crustal units were located in their present relative position within Tethys as a whole. From the mid-Permian, onwards the northern margin of Gondwana was affected by crustal extension. A Mesozoic ocean (Pindos-Mirdita ocean) then rifted during Early-Middle Triassic time, culminating in final continental break-up and seafloor spreading during the Late Triassic (Carnian-Norian). Subduction-influenced volcanics of mainly Early-Middle Triassic age probably reflect the extraction of magma from sub-continental lithosphere that was enriched in subduction-related fluids and volatiles during an earlier, ?Variscan subduction event. The existence of Upper Triassic mid-ocean ridge-type igneous rocks, known locally in Albania and Greece, points to rifting of a Red Sea-type oceanic basin rather than a back-arc basin related to contemporaneous subduction. After initial, inferred slow spreading at an Upper Triassic, rifted ocean ridge and spreading during the Early Jurassic, the ocean basin underwent regional convergence. Subduction was initiated at, or near, a spreading axis perhaps adjacent to an oceanic fracture zone. The Jurassic supra-subduction zone-type ophiolites of both Greece and Albania largely relate to melting of rising asthenosphere in the presence of volatiles (water) that originated from subducting oceanic lithosphere. High-magnesian boninite-type magmas that are present in both the Albanian and Greece ophiolites and some underlying melanges reflect remelting of previously depleted oceanic upper mantle. Localised MOR-type ophiolites of Late Middle Jurassic age, mainly exposed in NE Albania, were created at a rifted spreading axis. The amphibolite-facies metamorphic sole of the ophiolites was mainly derived from oceanic crust (including within-plate type seamounts), whereas the underlying lower-grade, greenschist facies sole was mainly sourced from the rifted continental margin. The melange, dismembered thrust sheets and polymict debris flows ("olistostromes") beneath the ophiolites formed by accretion and gravity reworking of continental margin units. The in situ radiolarian chert cover of the ophiolites in northern Albania is overlain by polymict debris flows ("olistostromes"). Pelagic carbonate deposition followed during Tithonian-Berriasian time and then restoration of a regional carbonate platform during the Cretaceous. Exhumation of deeply buried parts of the over-ridden continental margin probably took place during the Early Cretaceous. Structural evidence, mainly from northern Greece (Vourinos, Pindos and Othris areas), indicates that the ophiolites, the metamorphic sole, the accretionary melange, and the underlying continental margin units were all deformed by top-to-the-northeast thrusting during Late Middle-Early Late Jurassic time. However, such kinematic evidence is not obviously replicated in Albania, where there are reports of ~southwest-directed (or variable) emplacement. Remaining Pindos-Mirdita oceanic crust subducted ~southwestwards during Late Cretaceous-Eocene time, while oceanic crust continued to form in the south-Aegean region at least locally during Late Cretaceous time. During Early Cenozoic time the Pindos-Mirdita ocean closed progressively southwards, triggering mainly southward progradation of turbidites derived from the over-riding Korabi-Pelagonian microcontinent. Smaller volumes of sediment were also derived from the Apulia (Adria) continent. The Mesohellenic Trough of Greece and its counterpart in Albania evolved from an Eocene fore-arc-type basin above subducting oceanic lithosphere to a thrust-top basin as continental crust continued to underthrust during the Oligocene after final closure of the Pindos-Mirdita ocean. Miocene and Plio-Quaternary successor flexural foredeeps developed in response to continuing regional plate convergence. The preferred tectonic alternatives are assembled into a new overall tectonic model, which in turn needs to be tested and developed in the light of future studies. Reference: Robertson, A.H.F. Tectonic development of Greece and Albania in the context of alternative reconstructions of Tethys in the Eastern Mediterranean region during Late Palaeozoic-Cenozoic time. International Geological Review, in press.

Preliminary assessment of a Cretaceous-Paleogene Atlantic passive margin, Serrania del Interior and Central Ranges, Venezuela/Trinidad

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pindell, J.L.; Drake, C.L.; Pitman, W.C.

1991-03-01

For several decades, Cretaceous arc collision was assumed along northern Venezuela based on isotopic ages of metamorphic minerals. From subsidence histories in Venezuelan/Trinidadian basins, however, it is now clear that the Cretaceous metamorphic rocks were emplaced southeastward as allochthons above an autochthonous suite of rocks in the Cenozoic, and that the pre-Cenozoic autochthonous rocks represent a Mesozoic passive margin. The passive margin rocks have been metamorphosed separately during overthrusting by the allochthons in central Venezuela, but they are uplifted but not significantly metamorphosed in Eastern Venezuela and Trinidad. There, in the Serrania del Interior and Central Ranges of Venezuela/Trinidad, Mesozoic-Paleogenemore » passive margin sequences were uplifted in Neogene time, when the Caribbean Plate arrived from the west and transpressionally inverted the passive margin. Thus, this portion of South America's Atlantic margin subsided thermally without tectonism from Jurassic to Eocene time, and these sections comprise the only Mesozoic-Cenozoic truly passive Atlantic margin in the Western Hemisphere that is now exposed for direct study. Direct assessments of sedimentological, depositional and faunal features indicative of, and changes in, water depth for Cretaceous and Paleogene time may be made here relative to a thermally subsiding passive margin without the complications of tectonism. Work is underway, and preliminary assessments presented here suggest that sea level changes of Cretaceous-Paleogene time are not as pronounced as the frequent large and rapid sea level falls and rises that are promoted by some.« less

Methods of defining the non-inferiority margin in randomized, double-blind controlled trials: a systematic review.

PubMed

Althunian, Turki A; de Boer, Anthonius; Klungel, Olaf H; Insani, Widya N; Groenwold, Rolf H H

2017-03-07

There is no consensus on the preferred method for defining the non-inferiority margin in non-inferiority trials, and previous studies showed that the rationale for its choice is often not reported. This study investigated how the non-inferiority margin is defined in the published literature, and whether its reporting has changed over time. A systematic PubMed search was conducted for all published randomized, double-blind, non-inferiority trials from January 1, 1966, to February 6, 2015. The primary outcome was the number of margins that were defined by methods other than the historical evidence of the active comparator. This was evaluated for a time trend. We also assessed the under-reporting of the methods of defining the margin as a secondary outcome, and whether this changed over time. Both outcomes were analyzed using a Poisson log-linear model. Predictors for better reporting of the methods, and the use of the fixed-margin method (one of the historical evidence methods) were also analyzed using logistic regression. Two hundred seventy-three articles were included, which account for 273 non-inferiority margins. There was no statistically significant difference in the number of margins that were defined by other methods compared to those defined based on the historical evidence (ratio 2.17, 95% CI 0.86 to 5.82, p = 0.11), and this did not change over time. The number of margins for which methods were unreported was similar to those with reported methods (ratio 1.35, 95% CI 0.76 to 2.43, p = 0.31), with no change over time. The method of defining the margin was less often reported in journals with low-impact factors compared to journals with high-impact factors (OR 0.20; 95% CI 0.10 to 0.37, p < 0.0001). The publication of the FDA draft guidance in 2010 was associated with increased reporting of the fixed-margin method (after versus before 2010) (OR 3.54; 95% CI 1.12 to 13.35, p = 0.04). Non-inferiority margins are not commonly defined based on the historical evidence of the active comparator, and they are poorly reported. Authors, reviewers, and editors need to take notice of reporting this critical information to allow for better judgment of non-inferiority trials.

Holocene reef growth over irregular Pleistocene karst confirms major influence of hydrodynamic factors on Holocene reef development

NASA Astrophysics Data System (ADS)

Salas-Saavedra, Marcos; Dechnik, Belinda; Webb, Gregory E.; Webster, Jody M.; Zhao, Jian-xin; Nothdurft, Luke D.; Clark, Tara R.; Graham, Trevor; Duce, Stephanie

2018-01-01

Many factors govern reef growth through time, but their relative contributions are commonly poorly known. A prime example is the degree to which modern reef morphology is controlled by contemporary hydrodynamic settings or antecedent topography. Fortunately, reefs record essential information for interpreting palaeoclimate and palaeoenvironment within their structure as they accrete in response to environmental change. Five new cores recovered from the margin of Heron Reef, southern Great Barrier Reef (GBR), provide new insights into Holocene reef development and relationships between Holocene reefs and Pleistocene antecedent topography, suggesting much more irregular underlying topography than expected based on the configuration of the overlying modern reef margin. Cores were recovered to depths of 30 m and 94 new 230Th ages document growth between 8408 ± 24 and 2222 ± 16 yrs. BP. One core penetrated Pleistocene basement at ∼15.3 m with Holocene reef growth initiated by ∼8.4 ka BP. However, 1.83 km west along the same smooth margin, four cores failed to penetrate Pleistocene basement at depths between 20 and 30 m, suggesting that the margin at this location overlies a karst valley, or alternatively, the antecedent platform does not extend there. A 48 m-long margin-perpendicular transect of three cores documents the filling of this topographic low, at least 30 m beneath the current reef top, with seaward lateral accretion at a rate of 34.3 m/ka. Cores indicate steady vertical and lateral accretion between 3.2 and 1.8 ka BP with no evidence of the hiatus in reef flat progradation seen in most other offshore reefs of the GBR at that time. These cores suggest that the relative protection afforded by the valley allowed for unconsolidated sediment to accumulate, enabling continuous progradation even when other areas of the reef flat appear to have 'turned off'. Additionally, the cores suggest that although reefs in the southern GBR clearly owe their location to Pleistocene antecedent topography, modern reef morphology at sea level primarily reflects the interaction of Holocene reef communities with contemporary hydrodynamics.

Transition from magma dominant to magma poor rifting along the Nova Scotia Continental Margin

NASA Astrophysics Data System (ADS)

Lau, K. H.; Louden, K. E.; Nedimović, M. R.; Whitehead, M.; Farkas, A.; Watremez, L.; Dehler, S. A.

2011-12-01

Passive margins have been characterized as magma-dominant (volcanic) or magma-poor (non-volcanic). However, the conditions under which margins might switch states are not well understood as they typically have been studied as end member examples in isolation to each other. The Nova Scotia (NS) continental margin, however, offers an opportunity to study the nature of such a transition between the magma-dominant US East Coast margin to the south and the magma-poor Newfoundland margin to the north within a single rift segment. This transition is evidenced by a clear along-strike reduction in features characteristic of syn-rift volcanism from south-to-north along the NS margin, such as the weakening of the East Coast Magnetic Anomaly (ECMA) and the coincident disappearance of seaward dipping reflector sequences (SDRS) on multichannel seismic (MCS) reflection profiles. Results from recent industry MCS profiles along and across the margin suggest a potentially narrow magma-dominant to magma-poor along-strike transition between the southern and the central NS margin. Such a transition is broadly consistent with results of several widely-spaced, across-strike ocean bottom seismometer (OBS) wide-angle profiles. In the southern region, the crustal structure exhibits a narrow (~120-km wide) ocean-continent transition (OCT) with a high velocity (7.2 km/s) lower crust, interpreted as a gabbro-rich underplated melt, beneath the SDRS and the ECMA, similar to crustal models across the US East Coast. In contrast, profiles across the central and northern margin contain a much wider OCT (150-200-km wide) underlain by a low velocity mantle layer (7.3-7.9 km/s), interpreted as partially serpentinized olivine, which is similar to the magma-poor Newfoundland margin to the north. However, the central-to-northern OBS profiles also exhibit significant variations within the OCT and the along-strike continuity of these OCT structures is not yet clear. In November 2010, we acquired, in the OCTOPUS survey, wide-angle seismic data along a 240-km-long margin parallel profile extending from the central to the northern margin segments along an existing industry MCS profile (Ion/GX Technology NovaSPAN 5100). Twenty OBSs at 10-km spacing were analysed. A preliminary p-wave velocity model along the profile indicates that the cross-strike structures are continuous within the OCT. However, a substantial anisotropy in velocity (~8% lower parallel to the margin) is observed within the OCT. This result is consistent with an interpretation of partially serpentinized mantle that flowed perpendicular to the margin during its extension. In addition, along strike variations are also observed along the profile, which suggest a higher degree of volcanism and a thinner layer of serpentinized mantle to the southwest. These results provide a framework for future studies to the southwest to further investigate the transition to a magma-dominant regime towards the US East Coast.

Negev: Land, Water, and Life in a Desert Environment

NASA Astrophysics Data System (ADS)

Back, William

In view of the continuing increased concern about the extreme fragility of deserts and desert margins, Negev provides a timely discussion of land-use practices compatible with the often conflicting goals of preservation and development. The success o f agricultural and hydrologic experiments in the Negev desert of Israel offers hope to the large percentage of the world's population that lives with an unacceptably low quality of life in desert margins. Deserts are the one remaining type of open space that, with proper use, has the potential for alleviating the misery often associated with expanding population.In addition to the science in the book, the author repeatedly reinforces the concept that “western civilization is inextricably bound to the Negev and its environs, from which it has drawn, via its desert-born religions—Judasium, Christianity, and Islam—many of the mores and concepts, and much of the imagery and love of the desert, including man's relation to nature and to ‘God’.” Deserts often are erroneously perceived to be areas of no water: In reality, these are areas in which a little rainfall occurs sporadically and unpredictably over time. This meager water supply can be meticulously garnered to produce nutritious crops and forage.

The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an in vivo confocal and histological study

PubMed Central

Knop, Erich; Knop, Nadja; Zhivov, Andrey; Kraak, Robert; Korb, Donald R; Blackie, Caroline; Greiner, Jack V; Guthoff, Rudolf

2011-01-01

The inner border of the eyelid margin is critically important for ocular surface integrity because it guarantees the thin spread of the tear film. Its exact morphology in the human is still insufficiently known. The histology in serial sections of upper and lower lid margins in whole-mount specimens from 10 human body donors was compared to in vivo confocal microscopy of eight eyes with a Heidelberg retina-tomograph (HRT II) and attached Rostock cornea module. Behind the posterior margin of the Meibomian orifices, the cornified epidermis stopped abruptly and was replaced by a continuous layer of para-keratinized (pk) cells followed by discontinuous pk cells. The pk cells covered the muco-cutaneous junction (MCJ), the surface of which corresponded to the line of Marx (0.2–0.3 mm wide). Then a stratified epithelium with a conjunctival structure of cuboidal cells, some pk cells, and goblet cells formed an epithelial elevation of typically about 100 μm initial thickness (lid wiper). This continued for 0.3–1.5 mm and formed a slope. The MCJ and lid wiper extended all along the lid margin from nasal to temporal positions in the upper and lower lids. Details of the epithelium and connective tissue were also detectable using the Rostock cornea module. The human inner lid border has distinct zones. Due to its location and morphology, the epithelial lip of the lid wiper appears a suitable structure to spread the tear film and is distinct from the MCJ/line of Marx. Better knowledge of the lid margin appears important for understanding dry eye disease and its morphology can be analysed clinically by in vivo confocal microscopy. PMID:21413985

Tectonics of the Western Gulf of Oman

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, R.S.; Ross, D.A.

1979-07-10

The Oman line, running northward from the Strait of Hormuz separates a continent-continent plate boundary to the northwest (Persian Gulf region) from an ocean-continent plate boundary to the southeast (Gulf of Oman region). A large basement ridge detected on multichannel seismic reflection and gravity profiles to the west of the Oman line is probably a subsurface continuation of the Musandam peninsula beneath the Strait of Hormuz. Collision and underthrusting beneath Iran of the Arabian plate on which this ridge lies has caused many of the large earthquakes that have occurred in this region. Convergence between the oceanic crust of themore » Arabian plate beneath the Gulf of Oman and the continental Eurasian plate beneath Iran to the north is accommodated by northward dipping subduction. A deformed sediment prism which forms the offshore Makran continental margin and which extends onto land in the Iranian Makran has accumulated above the descending plate. In the western part of the Gulf of Oman, continued convergence has brought the opposing continental margin of Oman into contact with the Makran continental margin. This is an example of the initial stages of a continent-continent type collision. A model of imbricate thrusting is proposed to explain the development of the fold ridges and basins on the Makran continental margin. Sediments from the subducting plate are buckled and incorporated into the edge of the Makran continental margin in deformed wedges and subsequently uplifted along major faults that penetrate the accretionary prism further to the north.« less

Rapid and continuous magnetic separation in droplet microfluidic devices

DOE PAGES

Brouzes, Eric; Kruse, Travis; Kimmerling, Robert; ...

2014-12-03

Here, we present a droplet microfluidic method to extract molecules of interest from a droplet in a rapid and continuous fashion. We accomplish this by first marginalizing functionalized super-paramagnetic beads within the droplet using a magnetic field, and then splitting the droplet into one droplet containing the majority of magnetic beads and one droplet containing the minority fraction. We quantitatively analysed the factors which affect the efficiency of marginalization and droplet splitting to optimize the enrichment of magnetic beads. We first characterized the interplay between the droplet velocity and the strength of the magnetic field and its effect on marginalization.more » We found that marginalization is optimal at the midline of the magnet and that marginalization is a good predictor of bead enrichment through splitting at low to moderate droplet velocities. Finally, we focused our efforts on manipulating the splitting profile to improve the enrichment provided by asymmetric splitting. We designed asymmetric splitting forks that employ capillary effects to preferentially extract the bead-rich regions of the droplets. Our strategy represents a framework to optimize magnetic bead enrichment methods tailored to the requirements of specific droplet-based applications. We anticipate that our separation technology is well suited for applications in single-cell genomics and proteomics. In particular, our method could be used to separate mRNA bound to poly-dT functionalized magnetic microparticles from single cell lysates to prepare single-cell cDNA libraries.« less

Great earthquakes along the Western United States continental margin: implications for hazards, stratigraphy and turbidite lithology

NASA Astrophysics Data System (ADS)

Nelson, C. H.; Gutiérrez Pastor, J.; Goldfinger, C.; Escutia, C.

2012-11-01

We summarize the importance of great earthquakes (Mw ≳ 8) for hazards, stratigraphy of basin floors, and turbidite lithology along the active tectonic continental margins of the Cascadia subduction zone and the northern San Andreas Transform Fault by utilizing studies of swath bathymetry visual core descriptions, grain size analysis, X-ray radiographs and physical properties. Recurrence times of Holocene turbidites as proxies for earthquakes on the Cascadia and northern California margins are analyzed using two methods: (1) radiometric dating (14C method), and (2) relative dating, using hemipelagic sediment thickness and sedimentation rates (H method). The H method provides (1) the best estimate of minimum recurrence times, which are the most important for seismic hazards risk analysis, and (2) the most complete dataset of recurrence times, which shows a normal distribution pattern for paleoseismic turbidite frequencies. We observe that, on these tectonically active continental margins, during the sea-level highstand of Holocene time, triggering of turbidity currents is controlled dominantly by earthquakes, and paleoseismic turbidites have an average recurrence time of ~550 yr in northern Cascadia Basin and ~200 yr along northern California margin. The minimum recurrence times for great earthquakes are approximately 300 yr for the Cascadia subduction zone and 130 yr for the northern San Andreas Fault, which indicates both fault systems are in (Cascadia) or very close (San Andreas) to the early window for another great earthquake. On active tectonic margins with great earthquakes, the volumes of mass transport deposits (MTDs) are limited on basin floors along the margins. The maximum run-out distances of MTD sheets across abyssal-basin floors along active margins are an order of magnitude less (~100 km) than on passive margins (~1000 km). The great earthquakes along the Cascadia and northern California margins cause seismic strengthening of the sediment, which results in a margin stratigraphy of minor MTDs compared to the turbidite-system deposits. In contrast, the MTDs and turbidites are equally intermixed on basin floors along passive margins with a mud-rich continental slope, such as the northern Gulf of Mexico. Great earthquakes also result in characteristic seismo-turbidite lithology. Along the Cascadia margin, the number and character of multiple coarse pulses for correlative individual turbidites generally remain constant both upstream and downstream in different channel systems for 600 km along the margin. This suggests that the earthquake shaking or aftershock signature is normally preserved, for the stronger (Mw ≥ 9) Cascadia earthquakes. In contrast, the generally weaker (Mw = or <8) California earthquakes result in upstream simple fining-up turbidites in single tributary canyons and channels; however, downstream mainly stacked turbidites result from synchronously triggered multiple turbidity currents that deposit in channels below confluences of the tributaries. Consequently, both downstream channel confluences and the strongest (Mw ≥ 9) great earthquakes contribute to multi-pulsed and stacked turbidites that are typical for seismo-turbidites generated by a single great earthquake. Earthquake triggering and multi-pulsed or stacked turbidites also become an alternative explanation for amalgamated turbidite beds in active tectonic margins, in addition to other classic explanations. The sedimentologic characteristics of turbidites triggered by great earthquakes along the Cascadia and northern California margins provide criteria to help distinguish seismo-turbidites in other active tectonic margins.

Highly integrated digital engine control system on an F-15 airplane

NASA Technical Reports Server (NTRS)

Burcham, F. W., Jr.; Haering, E. A., Jr.

1984-01-01

The Highly Integrated Digital Electronic Control (HIDEC) program will demonstrate and evaluate the improvements in performance and mission effectiveness that result from integrated engine/airframe control systems. This system is being used on the F-15 airplane. An integrated flightpath management mode and an integrated adaptive engine stall margin mode are implemented into the system. The adaptive stall margin mode is a highly integrated mode in which the airplane flight conditions, the resulting inlet distortion, and the engine stall margin are continuously computed; the excess stall margin is used to uptrim the engine for more thrust. The integrated flightpath management mode optimizes the flightpath and throttle setting to reach a desired flight condition. The increase in thrust and the improvement in airplane performance is discussed.

Gravity fluctuations induced by magma convection at Kilauea Volcano, Hawai'i

USGS Publications Warehouse

Carbone, Daniele; Poland, Michael P.

2012-01-01

Convection in magma chambers is thought to play a key role in the activity of persistently active volcanoes, but has only been inferred indirectly from geochemical observations or simulated numerically. Continuous microgravity measurements, which track changes in subsurface mass distribution over time, provide a potential method for characterizing convection in magma reservoirs. We recorded gravity oscillations with a period of ~150 s at two continuous gravity stations at the summit of Kīlauea Volcano, Hawai‘i. The oscillations are not related to inertial accelerations caused by seismic activity, but instead indicate variations in subsurface mass. Source modeling suggests that the oscillations are caused by density inversions in a magma reservoir located ~1 km beneath the east margin of Halema‘uma‘u Crater in Kīlauea Caldera—a location of known magma storage.

Geophysical evidence for a transform margin offshore Western Algeria: a witness of a subduction-transform edge propagator?

NASA Astrophysics Data System (ADS)

Badji, Rabia; Charvis, Philippe; Bracene, Rabah; Galve, Audrey; Badsi, Madjid; Ribodetti, Alessandra; Benaissa, Zahia; Klingelhoefer, Frauke; Medaouri, Mourad; Beslier, Marie-Odile

2015-02-01

For the first time, a deep seismic data set acquired in the frame of the Algerian-French SPIRAL program provides new insights regarding the origin of the westernmost Algerian margin and basin. We performed a tomographic inversion of traveltimes along a 100-km-long wide-angle seismic profile shot over 40 ocean bottom seismometers offshore Mostaganem (Northwestern Algeria). The resulting velocity model and multichannel seismic reflection profiles show a thin (3-4 km thick) oceanic crust. The narrow ocean-continent transition (less than 10 km wide) is bounded by vertical faults and surmounted by a narrow almost continuous basin filled with Miocene to Quaternary sediments. This fault system, as well as the faults organized in a negative-flower structure on the continent side, marks a major strike-slip fault system. The extremely sharp variation of the Moho depth (up to 45 ± 3°) beneath the continental border underscores the absence of continental extension in this area. All these features support the hypothesis that this part of the margin from Oran to Tenes, trending N65-N70°E, is a fossil subduction-transform edge propagator fault, vestige of the propagation of the edge of the Gibraltar subduction zone during the westward migration of the Alborán domain.

Geology of continental margins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

With continued high interest in offshore petroleum exploration, the 1977 AAPG Short Course presents the latest interpretations of new data bearing on the geology and geophysics of continental margins. Seven well-known earth scientists have organized an integrated program covering major topics involved in the development of ocean basins and continental margins with emphasis on the slopes and rises. The discussion of plate tectonics and evolution of continental margins is followed by presentations on the stratigraphy and structure of pull-apart and compressional margins. Prospective petroleum source rocks, their organic content, rate of burial, and distribution on slopes and rises of differentmore » margin types is covered. Prospective reservoir rock patterns are related to depositional processes and to the sedimentary and structural histories for different types of continental margins. Finally, the seismic recognition of depositional facies on slopes and rises for different margin types with varying rates of sediment supply during eustatic sea-level changes are discussed. The course with this syllabus offers an invaluable opportunity for explorationists to refresh their understanding of the geology associated with an important petroleum frontier. In addition, the course sets forth a technical frame of reference for the case-histoy papers to be presented later in the AAPG Research Symposium on the Petroleum Potential of Slopes, Rises, and Plateaus.« less

Subduction and exhumation of a continental margin in the Scandinavian Caledonides: Insights from ultrahigh pressure metamorphism, late orogenic basins and 3D numerical modelling

NASA Astrophysics Data System (ADS)

Cuthbert, Simon

2017-04-01

The Scandinavian Caledonides (SC) represents a plate collision zone of Himalayan style and scale. Three fundamental characteristics of this orogen are: (1) early foreland-directed, tectonic transport and stacking of nappes; (2) late, wholesale reversal of tectonic transport; (3) ultrahigh pressure metamorphism of felsic crust derived from the underthrusting plate at several levels in the orogenic wedge and below the main thrust surface, indicating subduction of continental crust into the mantle. The significance of this for crustal evolution is the profound remodeling of continental crust, direct geochemical interaction of such crust and the mantle and the opening of accommodation space trapping large volumes of clastic detritus within the orogen. The orogenic wedge of the SC was derived from the upper crust of the Baltica continental margin (a hyper-extended passive margin), plus terranes derived from an assemblage of outboard arcs and intra-oceanic basins and, at the highest structural level, elements of the Laurentian margin. Nappe emplacement was driven by Scandian ( 430Ma) collision of Baltica with Laurentia, but emerging Middle Ordovician ages for diamond-facies metamorphism for the most outboard (or rifted) elements of Baltica suggest prior collision with an arc or microcontinent. Nappes derived from Baltica continental crust were subducted, in some cases to depths sufficient to form diamond. These then detached from the upper part of the down-going plate along major thrust faults, at which time they ceased to descend and possibly rose along the subduction channel. Subduction of the remaining continental margin continued below these nappes, possibly driven by slab-pull of the previously subducted Iapetus oceanic lithosphere and metamorphic densification of subducted felsic continental margin. 3D numerical modelling based upon a Caledonide-like plate scenario shows that if a continental corner or promontory enters the subduction zone, the continental margin descends to greater depths than for a simple orthogonal collision and its modelled thermal evolution is consistent with UHP metamorphic assemblages recorded in the southern part of the SC. Furthermore, a tear initiates at the promontary tip along the ocean-continent junction and propagates rapidly along the orogen. The buoyant upthrust of the subducted margin can then lead to reversal of the motion vector of the entire subducting continent, which withdraws the subducted lithospheric margin out of the subduction channel ("eduction"). Because of the diachroneity of slab failure, the continent also rotates, which causes the eduction vector to change azimuth over time. These model behaviours are consistent with the late orogenic structural evolution of the southern SC. However, during the final exhumation stage the crust may not have acted entirely coherently, as some eduction models propose: There is evidence that some inboard Baltica crust experienced late, shallow subduction before detaching as giant "flakes" that carried the orogenic wedge piggyback, forelandwards. Eduction and flake-tectonics could have operated coevally; the model system does not preclude this. Finally, the traction of a large educting (or extruding) mass of continental margin against the overlying orogenic wedge may have stretched and ruptured the wedge, resulting in opening of the late-orogenic Old Red Sandstone molasse basins.

Evidence for coral island formation during rising sea level in the central Pacific Ocean

NASA Astrophysics Data System (ADS)

Kench, Paul S.; Owen, Susan D.; Ford, Murray R.

2014-02-01

The timing and evolution of Jabat Island, Marshall Islands, was investigated using morphostratigraphic analysis and radiometric dating. Results show the first evidence of island building in the Pacific during latter stages of Holocene sea level rise. A three-phase model of development of Jabat is presented. Initially, rapid accumulation of coarse sediments on Jabat occurred 4800-4000 years B.P. across a reef flat higher than present level, as sea level continued to rise. During the highstand, island margins and particularly the western margin accreted vertically to 2.5-3.0 m above contemporary ridge elevations. This accumulation phase was dominated by sand-size sediments. Phase three involved deposition of gravel ridges on the northern reef, as sea level fell to present position. Jabat has remained geomorphically stable for the past 2000 years. Findings suggest reef platforms may accommodate the oldest reef islands in atoll systems, which may have profound implications for questions of prehistoric migration through Pacific archipelagos.

Metallogenesis and tectonics of the Russian Far East, Alaska, and the Canadian Cordillera

USGS Publications Warehouse

Nokleberg, Warren J.; Bundtzen, Thomas K.; Eremin, Roman A.; Ratkin, Vladimir V.; Dawson, Kenneth M.; Shpikerman, Vladimir I.; Goryachev, Nikolai A.; Byalobzhesky, Stanislav G.; Frolov, Yuri F.; Khanchuk, Alexander I.; Koch, Richard D.; Monger, James W.H.; Pozdeev, Anany I.; Rozenblum, Ilya S.; Rodionov, Sergey M.; Parfenov, Leonid M.; Scotese, Christopher R.; Sidorov, Anatoly A.

2005-01-01

The Proterozoic and Phanerozoic metallogenic and tectonic evolution of the Russian Far East, Alaska, and the Canadian Cordillera is recorded in the cratons, craton margins, and orogenic collages of the Circum-North Pacific mountain belts that separate the North Pacific from the eastern North Asian and western North American Cratons. The collages consist of tectonostratigraphic terranes and contained metallogenic belts, which are composed of fragments of igneous arcs, accretionary-wedge and subduction-zone complexes, passive continental margins, and cratons. The terranes are overlapped by continental-margin-arc and sedimentary-basin assemblages and contained metallogenic belts. The metallogenic and geologic history of terranes, overlap assemblages, cratons, and craton margins has been complicated by postaccretion dismemberment and translation during strike-slip faulting that occurred subparallel to continental margins. Seven processes overlapping in time were responsible for most of metallogenic and geologic complexities of the region (1) In the Early and Middle Proterozoic, marine sedimentary basins developed on major cratons and were the loci for ironstone (Superior Fe) deposits and sediment-hosted Cu deposits that occur along both the North Asia Craton and North American Craton Margin. (2) In the Late Proterozoic, Late Devonian, and Early Carboniferous, major periods of rifting occurred along the ancestral margins of present-day Northeast Asia and northwestern North America. The rifting resulted in fragmentation of each continent, and formation of cratonal and passive continental-margin terranes that eventually migrated and accreted to other sites along the evolving margins of the original or adjacent continents. The rifting also resulted in formation of various massive-sulfide metallogenic belts. (3) From about the late Paleozoic through the mid-Cretaceous, a succession of island arcs and contained igneous-arc-related metallogenic belts and tectonically paired subduction zones formed near continental margins. (4) From about mainly the mid-Cretaceous through the present, a succession of continental-margin igneous arcs (some extending offshore into island arcs) and contained metallogenic belts, and tectonically paired subduction zones formed along the continental margins. (5) From about the Jurassic to the present, oblique convergence and rotations caused orogen-parallel sinistral, and then dextral displacements within the plate margins of the Northeast Asian and North American Cratons. The oblique convergences and rotations resulted in the fragmentation, displacement, and duplication of formerly more continuous arcs, subduction zones, passive continental margins, and contained metallogenic belts. These fragments were subsequently accreted along the margins of the expanding continental margins. (6) From the Early Jurassic through Tertiary, movement of the upper continental plates toward subduction zones resulted in strong plate coupling and accretion of the former island arcs, subduction zones, and contained metallogenic belts to continental margins. In this region, the multiple arc accretions were accompanied and followed by crustal thickening, anatexis, metamorphism, formation of collision-related metallogenic belts, and uplift; this resulted in the substantial growth of the North Asian and North American continents. (7) In the middle and late Cenozoic, oblique to orthogonal convergence of the Pacific Plate with present-day Alaska and Northeast Asia resulted in formation of the present ring of volcanoes and contained metallogenic belts around the Circum-North Pacific. Oblique convergence between the Pacific Plate and Alaska also resulted in major dextral-slip faulting in interior and southern Alaska and along the western part of the Aleutian- Wrangell arc. Associated with dextral-slip faulting was crustal extrusion of terranes from western Alaska into the Bering Sea.

Petrology and tectonics of Phanerozoic continent formation: From island arcs to accretion and continental arc magmatism

USGS Publications Warehouse

Lee, C.-T.A.; Morton, D.M.; Kistler, R.W.; Baird, A.K.

2007-01-01

Mesozoic continental arcs in the North American Cordillera were examined here to establish a baseline model for Phanerozoic continent formation. We combine new trace-element data on lower crustal xenoliths from the Mesozoic Sierra Nevada Batholith with an extensive grid-based geochemical map of the Peninsular Ranges Batholith, the southern equivalent of the Sierras. Collectively, these observations give a three-dimensional view of the crust, which permits the petrogenesis and tectonics of Phanerozoic crust formation to be linked in space and time. Subduction of the Farallon plate beneath North America during the Triassic to early Cretaceous was characterized by trench retreat and slab rollback because old and cold oceanic lithosphere was being subducted. This generated an extensional subduction zone, which created fringing island arcs just off the Paleozoic continental margin. However, as the age of the Farallon plate at the time of subduction decreased, the extensional environment waned, allowing the fringing island arc to accrete onto the continental margin. With continued subduction, a continental arc was born and a progressively more compressional environment developed as the age of subducting slab continued to young. Refinement into a felsic crust occurred after accretion, that is, during the continental arc stage, wherein a thickened crustal and lithospheric column permitted a longer differentiation column. New basaltic arc magmas underplate and intrude the accreted terrane, suture, and former continental margin. Interaction of these basaltic magmas with pre-existing crust and lithospheric mantle created garnet pyroxenitic mafic cumulates by fractional crystallization at depth as well as gabbroic and garnet pyroxenitic restites at shallower levels by melting of pre-existing lower crust. The complementary felsic plutons formed by these deep-seated differentiation processes rose into the upper crust, stitching together the accreted terrane, suture and former continental margin. The mafic cumulates and restites, owing to their high densities, eventually foundered into the mantle, leaving behind a more felsic crust. Our grid-based sampling allows us to estimate an unbiased average upper crustal composition for the Peninsular Ranges Batholith. Major and trace-element compositions are very similar to global continental crust averaged over space and time, but in detail, the Peninsular Ranges are slightly lower in compatible to mildly incompatible elements, MgO, Mg#, V, Sc, Co, and Cr. The compositional similarities suggest a strong arc component in global continental crust, but the slight discrepancies suggest that additional crust formation processes are also important in continent formation as a whole. Finally, the delaminated Sierran garnet pyroxenites have some of the lowest U/Pb ratios ever measured for silicate rocks. Such material, if recycled and stored in the deep mantle, would generate a reservoir with very unradiogenic Pb, providing one solution to the global Pb isotope paradox. ?? 2007 Elsevier B.V. All rights reserved.

The Application of Margin in Life Theory in Regard to Attrition and Remediation among Emergency Medicine Residents

ERIC Educational Resources Information Center

Kalynych, Colleen J.

2010-01-01

Medical residency is a time of high stress, long hours, high case loads, fatigue, and lack of free time. Burnout rates among residents have been reported to be between 25-76%. Scant literature exists in regard to resident stress and its impact on learning and attrition during residency. The theory of margin posits that a healthy margin is…

Apparent episodicity of magmatic activity based on radiometric age determination: A section in The United States Geological Survey in Alaska: Accomplishments during 1980

USGS Publications Warehouse

Wilson, Frederic H.; Shew, Nora B.

1982-01-01

Results of recent potassium-argon age studies in the Chignik region, Alaska, (Wilson, 1980; Wilson and others, 1982) have suggested a distinct episodicity in igneous activity during Tertiary time. To date work on the Aleutian magmatic arc indicates that plutonic activity took place along the present outer Pacific margin and in the northern Alaska-Aleutian Range batholith (Reed and Lanphere, 1973; Kienle and Turner, 1976; DeLong and others, 1978) in latest Cretaceous and earliest Tertiary time (70-58 m.y.) and was followed by a hiatus lasting until late Eocene ( 45 m.y~) time. Late Eocene to earliest Miocene ( 45-20 m.y.) magmatic activity was followed by a middle Miocene hiatus (10 m.y.). Since that time, magmatic activity in the Aleutian arc has been continuous.

Progress in using real-time GPS for seismic monitoring of the Cascadia megathrust

NASA Astrophysics Data System (ADS)

Szeliga, W. M.; Melbourne, T. I.; Santillan, V. M.; Scrivner, C.; Webb, F.

2014-12-01

We report on progress in our development of a comprehensive real-time GPS-based seismic monitoring system for the Cascadia subduction zone. This system is based on 1 Hz point position estimates computed in the ITRF08 reference frame. Convergence from phase and range observables to point position estimates is accelerated using a Kalman filter based, on-line stream editor. Positions are estimated using a short-arc approach and algorithms from JPL's GIPSY-OASIS software with satellite clock and orbit products from the International GNSS Service (IGS). The resulting positions show typical RMS scatter of 2.5 cm in the horizontal and 5 cm in the vertical with latencies below 2 seconds. To facilitate the use of these point position streams for applications such as seismic monitoring, we broadcast real-time positions and covariances using custom-built streaming software. This software is capable of buffering 24-hour streams for hundreds of stations and providing them through a REST-ful web interface. To demonstrate the power of this approach, we have developed a Java-based front-end that provides a real-time visual display of time-series, vector displacement, and contoured peak ground displacement. We have also implemented continuous estimation of finite fault slip along the Cascadia megathrust using an NIF approach. The resulting continuous slip distributions are combined with pre-computed tsunami Green's functions to generate real-time tsunami run-up estimates for the entire Cascadia coastal margin. This Java-based front-end is available for download through the PANGA website. We currently analyze 80 PBO and PANGA stations along the Cascadia margin and are gearing up to process all 400+ real-time stations operating in the Pacific Northwest, many of which are currently telemetered in real-time to CWU. These will serve as milestones towards our over-arching goal of extending our processing to include all of the available real-time streams from the Pacific rim. In addition, we are developing methodologies to combine our real-time solutions with those from Scripps Institute of Oceanography's PPP-AR real-time solutions as well as real-time solutions from the USGS. These combined products should improve the robustness and reliability of real-time point-position streams in the near future.

Marginal integrity of resin composite restorations restored with PPD initiatorcontaining resin composite cured by QTH, monowave and polywave LED units.

PubMed

Bortolotto, Tissiana; Betancourt, Francisco; Krejci, Ivo

2016-12-01

This study evaluated the influence of curing devices on marginal adaptation of cavities restored with self-etching adhesive containing CQ and PPD initiators and hybrid composite. Twenty-four class V (3 groups, n=8) with margins located on enamel and dentin were restored with Clearfil S3 Bond and Clearfil APX PLT, light-cured with a monowave LED, multiwave LED and halogen light-curing unit (LCU). Marginal adaptation was evaluated with SEM before/after thermo-mechanical loading (TML). On enamel, significantly lower % continuous margins (74.5±12.6) were found in group cured by multiwave LED when compared to monowave LED (87.6±9.5) and halogen LCU (94.4±9.1). The presence of enamel and composite fractures was significantly higher in the group light-cured with multiwave LED, probably due to an increased materials' friability resulted from an improved degree of cure. The clinician should aware that due to a distinct activation of both initiators, marginal quality may be influenced on the long-term.

On solid ground. Revenue gains continue to outpace growth in expenses, allowing U.S. hospitals to enjoy record profit and margin.

PubMed

Evans, Melanie

2007-10-29

Hospitals enjoyed a surge in profits last year, reporting an aggregate profit margin of 6%. Executives at financially strong systems credit long-term efforts to improve performance for the results. Elizabeth Concordia, left, of the University of Pittsburgh Medical Center system, says its efforts stressed ongoing consolidation and integration to wipe out waste and errors.

The nature, meaning and measurement of health and illness: an economic viewpoint.

PubMed

Williams, A

1985-01-01

Health can be seen as a capital asset, subject to depreciation due both to the passage of time (ageing) and to 'wear and tear'. It is valued for the flow of pain-free time and energy it offers us, and we can increase the quantity and quality of this 'flow' by appropriate care and maintenance, which may take the form of adopting a healthy life style or in seeking health care. The valuation of health (as a capital stock) can then be seen as the valuation of the time profile of the stream of pain-free time and energy we expect to get out of it. This in turn depends on the uses to which this time and energy can be put. Its use in paid work is relatively easily valued but unpaid work (especially work in the home) continues to be a source of difficulty, both in principle and in practice, in the search for appropriate money values. Leisure time is still more difficult, though for those in paid work whose remuneration is sensitive to the work/leisure balance, foregone net earnings at that margin may be used in the marginal value of leisure time. But the appropriateness of any valuation depends on the use to which it is to be put, and it is important to distinguish whether it is to reflect 'individual' or 'group' values, and whether it is for ex post compensation associated with some particular event, or for use in ex ante decision making where it is not known who the particular gainers and losers will be.

Miocene-Recent sediment flux in the south-central Alaskan fore-arc basin governed by flat-slab subduction

NASA Astrophysics Data System (ADS)

Finzel, Emily S.; Enkelmann, Eva

2017-04-01

The Cook Inlet in south-central Alaska contains the early Oligocene to Recent stratigraphic record of a fore-arc basin adjacent to a shallowly subducting oceanic plateau. Our new measured stratigraphic sections and detrital zircon U-Pb geochronology and Hf isotopes from Neogene strata and modern rivers illustrate the effects of flat-slab subduction on the depositional environments, provenance, and subsidence in fore-arc sedimentary systems. During the middle Miocene, fluvial systems emerged from the eastern, western, and northern margins of the basin. The axis of maximum subsidence was near the center of the basin, suggesting equal contributions from subsidence drivers on both margins. By the late Miocene, the axis of maximum subsidence had shifted westward and fluvial systems originating on the eastern margin of the basin above the flat-slab traversed the entire width of the basin. These mud-dominated systems reflect increased sediment flux from recycling of accretionary prism strata. Fluvial systems with headwaters above the flat-slab region continued to cross the basin during Pliocene time, but a change to sandstone-dominated strata with abundant volcanogenic grains signals a reactivation of the volcanic arc. The axis of maximum basin subsidence during late Miocene to Pliocene time is parallel to the strike of the subducting slab. Our data suggest that the character and strike-orientation of the down-going slab may provide a fundamental control on the nature of depositional systems, location of dominant provenance regions, and areas of maximum subsidence in fore-arc basins.

Lateral spread of heat during thyroidectomy using different haemostatic devices.

PubMed

Adamczewski, Zbigniew; Król, Aleksander; Kałużna-Markowska, Karolina; Brzeziński, Jan; Lewiński, Andrzej; Dedecjus, Marek

2015-01-01

The presented study is an attempt to comprehensively analyze the lateral spread of heat during thyroidectomy. Obtained results may be valuable in other surgical disciplines in which thermal analysis is difficult or impossible. The aim of the study was to evaluate the temperature distribution in the operating field during thyroidectomy performed with the use of modern haemostatic instruments, and to define the safety margin for the investigated devices. Ninety-three patients were thyroidectomised due to thyroid neoplasm. During all the operations the thermovisual measurements were carried out along with continuous intraoperative neuromonitoring of the recurrent laryngeal nerve (CIONM). Investigated patients were divided into 5 groups, named according to the applied haemostatic technique: LigaSure (N=17); ThermoStapler (N=20); Focus (N=19); SonoSurg (N=17) and Monopolar (N=20). At maximal performance settings, the highest working temperature was observed for the ThermoStapler, while the lowest temperature was recorded for the Monopolar. Safety margin and working time were increased in Focus and SonoSurg, compared to LigaSure and ThermoStapler. The differences in the necrosis thickness were negligible. The largest distance of the midline of the active blade from isotherm of 42ºC observed in the study was 5.51 mm; none of investigated devices used at a bigger distance had influence on the morphology of the electric signal of CIONM. The thermo-visual camera allows non-invasive, safe, and real-time monitoring and analysis of temperature distribution in the operation area during thyroidectomy. Proposed minimal safety margin for the analysed devices is 5.51 mm.

Adopting Disruptive Technologies in Traditional Universities: Continuing Education as an Incubator for Innovation.

ERIC Educational Resources Information Center

Archer, Walter; Anderson, Terry; Garrison, Randy

1999-01-01

Traditional universities are feeling the impact of "disruptive technologies" such as distance education. Seeing how businesses have responded to such disruptions, universities should "incubate" innovations in a semiautonomous unit such as continuing education, which can address new markets with low margins. (SK)

Weibull mixture regression for marginal inference in zero-heavy continuous outcomes.

PubMed

Gebregziabher, Mulugeta; Voronca, Delia; Teklehaimanot, Abeba; Santa Ana, Elizabeth J

2017-06-01

Continuous outcomes with preponderance of zero values are ubiquitous in data that arise from biomedical studies, for example studies of addictive disorders. This is known to lead to violation of standard assumptions in parametric inference and enhances the risk of misleading conclusions unless managed properly. Two-part models are commonly used to deal with this problem. However, standard two-part models have limitations with respect to obtaining parameter estimates that have marginal interpretation of covariate effects which are important in many biomedical applications. Recently marginalized two-part models are proposed but their development is limited to log-normal and log-skew-normal distributions. Thus, in this paper, we propose a finite mixture approach, with Weibull mixture regression as a special case, to deal with the problem. We use extensive simulation study to assess the performance of the proposed model in finite samples and to make comparisons with other family of models via statistical information and mean squared error criteria. We demonstrate its application on real data from a randomized controlled trial of addictive disorders. Our results show that a two-component Weibull mixture model is preferred for modeling zero-heavy continuous data when the non-zero part are simulated from Weibull or similar distributions such as Gamma or truncated Gauss.

Time-lagged response of carabid species richness and composition to past management practices and landscape context of semi-natural field margins.

PubMed

Alignier, Audrey; Aviron, Stéphanie

2017-12-15

Field margins are key features for the maintenance of biodiversity and associated ecosystem services in agricultural landscapes. Little is known about the effects of management practices of old semi-natural field margins, and their historical dimension regarding past management practices and landscape context is rarely considered. In this paper, the relative influence of recent and past management practices and landscape context (during the last five years) were assessed on the local biodiversity (species richness and composition) of carabid assemblages of field margins in agricultural landscapes of northwestern France. The results showed that recent patterns of carabid species richness and composition were best explained by management practices and landscape context measured four or five years ago. It suggests the existence of a time lag in the response of carabid assemblages to past environmental conditions of field margins. The relative contribution of past management practices and past landscape context varied depending on the spatial scale at which landscape context was taken into account. Carabid species richness was higher in grazed or sprayed field margins probably due to increased heterogeneity in habitat conditions. Field margins surrounded by grasslands and crops harbored species associated with open habitats whilst forest species dominated field margins surrounded by woodland. Landscape effect was higher at fine spatial scale, within 50 m around field margins. The present study highlights the importance of considering time-lagged responses of biodiversity when managing environment. It also suggests that old semi-natural field margins should not be considered as undisturbed habitats but more as management units being part of farming activities in agricultural landscapes, as for arable fields. Copyright © 2017 Elsevier Ltd. All rights reserved.

Read margin analysis of crossbar arrays using the cell-variability-aware simulation method

NASA Astrophysics Data System (ADS)

Sun, Wookyung; Choi, Sujin; Shin, Hyungsoon

2018-02-01

This paper proposes a new concept of read margin analysis of crossbar arrays using cell-variability-aware simulation. The size of the crossbar array should be considered to predict the read margin characteristic of the crossbar array because the read margin depends on the number of word lines and bit lines. However, an excessively high-CPU time is required to simulate large arrays using a commercial circuit simulator. A variability-aware MATLAB simulator that considers independent variability sources is developed to analyze the characteristics of the read margin according to the array size. The developed MATLAB simulator provides an effective method for reducing the simulation time while maintaining the accuracy of the read margin estimation in the crossbar array. The simulation is also highly efficient in analyzing the characteristic of the crossbar memory array considering the statistical variations in the cell characteristics.

[Microtubules suppress blebbing and stimulate lamellae extension in spreading fibroblasts].

PubMed

Tvorogova, A V; Vorob'ev, I A

2012-01-01

We compared spreading of Vero fibroblasts when microtubules were depolymerized or stabilized. After initial attachment cells start blebbing that continues for different time and abruptly transfers into spreading. After spreading initiation, most cells spread in an anisotropic manner through stochastic formation of lamellipodia. A second mode was rapid, isotropic spreading via formation of circular lamellum that occurs in 15% of cells. The rate of spreading was maximal at the beginning and decreased during the first hour according to logarithmic law. After 60 min many cells formed stable efges and started migrating on the substrate. However, cell area slowly continued to increase. Actin bundles are formed 20 min after cell attachment and they first run along cell boundary. This system disassembles within 20-40 min and is substituted with stress fibers crossing the cell. In the isotropically spread cells no actin bunbles are seen. Microtubules in the spreading cells enter into large blebs and all nascent lamella and later form radial array. When MTs has been depolymerized or stabilized blebbing started before cells attached to the substrate and continue much longer than in control cells. In both cases the initial rate of spreading decrease several fold, and remains constant for many hours. After 24 h the mean area occupied by cells with altered MT system was the same as in control. Alteration of MT system had moderate effect on actin system--formation of actin cables started at the same time as in control (within 20 min upon cell attachment), however, they grew even in cells undergoing prolonged blebbing. Actin cables running along cell margin were similar to tat in control cells, but they did not disappear up to 1 h. When stabilized, microtubules form chaotic array: they do not enter blebs and in spread cells run parallel to the cell margin at a distance of 3-5 microm. We conclude that dynamic microtubules speed up completion of blebbing and promote early stages of fibroblasts spreading.

SU-E-J-194: Continuous Patient Surface Monitoring and Motion Analysis During Lung SBRT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, E; Rioux, A; Benedict, S

2015-06-15

Purpose: Continuous monitoring of the SBRT lung patient motion during delivery is critical for ensuring adequate target volume margins in stereotactic body radiotherapy (SBRT). This work assesses the deviation of the patient surface motion using a real-time surface tracking system throughout treatment delivery. Methods: Our SBRT protocol employs abdominal compression to reduce the diaphragm movement to within 1 cm, and this is confirmed daily with fluoroscopy. Most patients are prescribed 3–5 fractions, and on treatment day a repeat motion analysis with fluoroscopy is performed, followed by a kV CBCT is aligned with the original planning CT image for 3D setupmore » confirmation. During this entire process a patient surface data restricted to whole chest or the sternum at the middle of the breathing cycle was captured using AlignRT optical surface tracking system and defined as a reference surface. For 10 patients, the deviation of the patient position from the reference surface was recorded during the SBRT delivery in the anterior-posterior (AP) direction at 3–6 measurements per second. Results: On average, the patient position deviated from the reference surface more than 4 mm, 3 mm and 2 mm in the AP direction for 0.95%, 3.7% and 11.1% of the total treatment time, respectively. Only one of the 10 patients showed that the maximum deviation of the patient surface during the SBRT delivery was greater than 1 cm. The average deviation of the patient surface from the reference surface during the SBRT delivery was not greater than 1.6 mm for any patient. Conclusion: This investigation indicates that AP motion can be significant even though the frequency is low. Continuous monitoring during SBRT has demonstrated value in monitoring patient motion ensuring that margins selected for SBRT are appropriate, and the use of non-ionizing and high-frequency imaging can provide useful indicators of motion during treatment.« less

Continental Margins of the Arctic Ocean: Implications for Law of the Sea

NASA Astrophysics Data System (ADS)

Mosher, David

2016-04-01

A coastal State must define the outer edge of its continental margin in order to be entitled to extend the outer limits of its continental shelf beyond 200 M, according to article 76 of the UN Convention on the Law of the Sea. The article prescribes the methods with which to make this definition and includes such metrics as water depth, seafloor gradient and thickness of sediment. Note the distinction between the "outer edge of the continental margin", which is the extent of the margin after application of the formula of article 76, and the "outer limit of the continental shelf", which is the limit after constraint criteria of article 76 are applied. For a relatively small ocean basin, the Arctic Ocean reveals a plethora of continental margin types reflecting both its complex tectonic origins and its diverse sedimentation history. These factors play important roles in determining the extended continental shelves of Arctic coastal States. This study highlights the critical factors that might determine the outer edge of continental margins in the Arctic Ocean as prescribed by article 76. Norway is the only Arctic coastal State that has had recommendations rendered by the Commission on the Limits of the Continental Shelf (CLCS). Russia and Denmark (Greenland) have made submissions to the CLCS to support their extended continental shelves in the Arctic and are awaiting recommendations. Canada has yet to make its submission and the US has not yet ratified the Convention. The various criteria that each coastal State has utilized or potentially can utilize to determine the outer edge of the continental margin are considered. Important criteria in the Arctic include, 1) morphological continuity of undersea features, such as the various ridges and spurs, with the landmass, 2) the tectonic origins and geologic affinities with the adjacent land masses of the margins and various ridges, 3) sedimentary processes, particularly along continental slopes, and 4) thickness and continuity of the sediment stratigraphy within the basins. The enclosed nature of the Arctic basin and the undersea ridges that transect the width of the basin result in complex geographies for the coastal States. The relevant fact, therefore, is that the five coastal States surrounding the ocean should have a common understanding of the geological and morphological features and the use of these features in determining the outer edge of the continental margin.

Flow of material under compression in weak lower continental crust can cause post-rift uplift of passive continental margins

NASA Astrophysics Data System (ADS)

Chalmers, James

2014-05-01

There are mountain ranges up to more than 2 km high along many passive continental margins (e.g. Norway, eastern Australia, eastern Brazil, SE and SW Africa, east and west Greenland etc.), dubbed Elevated Passive Continental Margins (EPCMs). EPCMs contain several features in common and observations indicate that uplift of these margins took place after continental break-up. There are many explanations for their formation but none that satisfy all the observations. Lack of a geodynamical mechanism has meant that there has been difficulty in getting the community to accept the observational evidence. Formation of a passive continental margin must take place under conditions of tension. After rifting ceases, however, the margin can come under compression from forces originating elsewhere on or below its plate, e.g. orogeny elsewhere in the plate or sub-lithospheric drag. The World Stress Map (www.world-stress-mp.org) shows that, where data exists, all EPCMs are currently under compression. Under sufficient compression, crust and/or lithosphere can fold, and Cloetingh & Burov (2010) showed that many continental areas may have folded in this way. The wavelengths of folding observed by Cloetingh & Burov (2010) imply that the lower crust is likely to be of intermediate composition; granitic lower crust would fold with a shorter wavelength and basic lower crust would mean that the whole lithosphere would have to fold as a unit resulting in a much longer wavelength. Continental crust more than 20 km thick would be separated from the mantle by a weak layer. However, crust less thick than that would contain no weak layers would become effectively annealed to the underlying strong mantle. Under sufficient horizontal compression stress, material can flow in the lower weak layer towards a continental margin from the continental side. The annealed extended crust and mantle under the rift means, however, that flow cannot continue towards the ocean. Mid- and lower crustal material therefore accumulates in the proximal rift and rift margin, thickening them and lifting them by isostatic response to the thickening. Flow into the rift margin is opposed by uplift and folding of the upper, strong crust, which imposes an additional normal stress, until crust thickens no more. However, flow continues through this thickened crust, thickening and uplifting the area "downstream", so widening the thickened area. Flow and uplift can continue until a reduction in imposed far-field compressive stress causes a consequent large reduction in inflow, thereby 'freezing' the thickened crust in place. Erosion of the uplifted area will lead to further uplift of the uneroded material because of the isostatic response to the erosion. Reference Cloetingh, S. & Burov, E. 2010: Lithospheric folding and sedimentary basin evolution: a review and analysis of formation mechanisms. Basin Research 22, 1365-2117. doi:10.1111/j.1365-2117.2010.00490.x.

Highly integrated digital engine control system on an F-15 airplane

NASA Technical Reports Server (NTRS)

Burcham, F. W., Jr.; Haering, E. A., Jr.

1984-01-01

The highly integrated digital electronic control (HIDEC) program will demonstrate and evaluate the improvements in performance and mission effectiveness that result from integrated engine-airframe control systems. This system is being used on the F-15 airplane at the Dryden Flight Research Facility of NASA Ames Research Center. An integrated flightpath management mode and an integrated adaptive engine stall margin mode are being implemented into the system. The adaptive stall margin mode is a highly integrated mode in which the airplane flight conditions, the resulting inlet distortion, and the engine stall margin are continuously computed; the excess stall margin is used to uptrim the engine for more thrust. The integrated flightpath management mode optimizes the flightpath and throttle setting to reach a desired flight condition. The increase in thrust and the improvement in airplane performance is discussed in this paper.

Marginal states in a cubic autocatalytic reaction

NASA Astrophysics Data System (ADS)

Das, Debojyoti; Ghosh, Pushpita; Ray, Deb Shankar

2011-09-01

Marginal steady state belongs to a special class of states in nonlinear dynamics. To realize this state we consider a cubic autocatalytic reaction A + 2B → 3B in a continuous-stirred-tank-reactor, where the flow rate of the reactant A can be controlled to manipulate the dynamical behavior of the open system. We demonstrate that when the flow rate is weakly noisy the autocatalytic reaction admits of a steady state which is marginal in nature and is surrounded by infinite number of periodic trajectories. When the uncatalyzed reaction A → B is included in the reaction scheme, there exists a marginal steady state which is a critical state corresponding to the point of transition between the flow branch and the equilibrium branch, similar to gas-liquid critical point of transition. This state loses its stability in the weak noise limit.

Institutionalizing Continuing Professional Education (CPE): Toward a Definition of the University Situation.

ERIC Educational Resources Information Center

Toombs, William; Lindsay, Carl A.

Issues related to the institutionalization of continuing professional education (CPE) within the university are considered. The components of marginality, the possible obstacles and incentives to institutionalization, and some of the support necessities are addressed, along with insights gained by a Pennsylvania State University effort to link the…

SU-D-18A-07: Towards 6-Degree-Of-Freedom Real-Time Motion Management in Cancer Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, C.Y.; Keall, P; Nasehi Tehrani, J

2014-06-01

Purpose: Lung tumor motion has been identified as a major issue that deteriorates treatment efficacy for radiotherapy, especially for SBRT. As tighter PTV margins are applied due to translational compensation, tumor rotation will become the dominant factor limiting tumor targeting accuracy. This is the world-first study quantifies lung tumor rotation by utilizing kV images with fiducial markers and a step towards 6-degree-of-freedom real-time cancer radiotherapy. Methods: Three or four gold coils were implanted as tumor surrogates in 3 lung cancer patients. 50 fractions of 8- minute, 10 Hz 4D CBCT projections were acquired for the patients immediately prior or aftermore » radiotherapy. The fiducial marker positions are segmented, reconstructed and used to determine tumour rotation by the iterative closest point algorithm. Different data acceptance and filtering methods were applied to accept data or smooth the marker trajectory. Results: The average rotation angles around the left/ right (LR), superior/inferior (SI), anterior/posterior (AP) rotations were found to be 0.8±4.2, -0.8±4.5 and 1.7±3.1 degrees respectively. For 28% of the treatment time, the lung tumors rotated more than 5° around the SI axis. Respiration-induced rotational motion was detected in 2 of the 3 lung patients. This can be explained by the patient developed atelectasis during the treatment period. Interestingly, no heart beating component of rotation was observed in the power spectrum. Different rotational types were observed within the patient cohort with large variations in the magnitude of the rotation between patients. Conclusions: For the first time, continuous tumor rotation has been measured for lung patients with gold fiducial markers. Tumors were found to undergo rotations of more than 5° for almost a third of the total treatment time. The study also demonstrated the feasibility of using continuously kV images for real-time lung tumour motion adaptive radiotherapy which can potentially reduce treatment margins and side effects. The authors acknowledge the financial support of an NHMRC Australia Fellowship.« less

Intrafraction Prostate Translations and Rotations During Hypofractionated Robotic Radiation Surgery: Dosimetric Impact of Correction Strategies and Margins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Water, Steven van de, E-mail: s.vandewater@erasmusmc.nl; Valli, Lorella; Alma Mater Studiorum, Department of Physics and Astronomy, Bologna University, Bologna

Purpose: To investigate the dosimetric impact of intrafraction prostate motion and the effect of robot correction strategies for hypofractionated CyberKnife treatments with a simultaneously integrated boost. Methods and Materials: A total of 548 real-time prostate motion tracks from 17 patients were available for dosimetric simulations of CyberKnife treatments, in which various correction strategies were included. Fixed time intervals between imaging/correction (15, 60, 180, and 360 seconds) were simulated, as well as adaptive timing (ie, the time interval reduced from 60 to 15 seconds in case prostate motion exceeded 3 mm or 2° in consecutive images). The simulated extent of robot corrections was alsomore » varied: no corrections, translational corrections only, and translational corrections combined with rotational corrections up to 5°, 10°, and perfect rotational correction. The correction strategies were evaluated for treatment plans with a 0-mm or 3-mm margin around the clinical target volume (CTV). We recorded CTV coverage (V{sub 100%}) and dose-volume parameters of the peripheral zone (boost), rectum, bladder, and urethra. Results: Planned dose parameters were increasingly preserved with larger extents of robot corrections. A time interval between corrections of 60 to 180 seconds provided optimal preservation of CTV coverage. To achieve 98% CTV coverage in 98% of the treatments, translational and rotational corrections up to 10° were required for the 0-mm margin plans, whereas translational and rotational corrections up to 5° were required for the 3-mm margin plans. Rectum and bladder were spared considerably better in the 0-mm margin plans. Adaptive timing did not improve delivered dose. Conclusions: Intrafraction prostate motion substantially affected the delivered dose but was compensated for effectively by robot corrections using a time interval of 60 to 180 seconds. A 0-mm margin required larger extents of additional rotational corrections than a 3-mm margin but resulted in lower doses to rectum and bladder.« less

Margins: a status report from the Annual Meeting of the American Society of Breast Surgeons.

PubMed

Harness, Jay K; Giuliano, Armando E; Pockaj, Barbara A; Downs-Kelly, Erinn

2014-10-01

Since the emergence of breast conserving surgery (BCS) as an alternative to mastectomy in the 1980's, there has been little consensus on what constitutes acceptable margins for cases of invasive breast cancer, how best to evaluate margins in the operating room, or an understanding of the challenging process of margin assessment by pathologists. The program committee for the 15th Annual Meeting of The American Society of Breast Surgeons organized a plenary session to discuss the latest thinking and guidelines for these important issues. The SSO/ASTRO Consensus Guideline on Margins for BCS was an important focus of discussion. The SSO/ASTRO consensus panelists concluded that "no ink on tumor" is an adequate surgical margin for BCS in patients with invasive breast cancers. Intraoperative strategies to decrease the incidence of positive margins include intraoperative localization techniques (wire-localization, ultrasound, radioactive seed) and intraoperative margin assessments with specimen radiography, imprint cytology, and frozen section. Studies also demonstrate the positive effect of shave margins with or without intraoperative margin assessment. The College of American Pathologists protocols for breast specimen margin evaluation consider multiple variables that can impact the proper assessment of margins. These variables include: tissue fixation time, specimen orientation, cold ischemia time, leaking ink, specimen pancaking and others that surgeons need to be aware of. Determining when "enough is enough" should not only be the application of guidelines and national standards, but also a multidisciplinary discussion between breast cancer specialists for what is right for the individual patient's unique circumstances.

Faster Trees: Strategies for Accelerated Training and Prediction of Random Forests for Classification of Polsar Images

NASA Astrophysics Data System (ADS)

Hänsch, Ronny; Hellwich, Olaf

2018-04-01

Random Forests have continuously proven to be one of the most accurate, robust, as well as efficient methods for the supervised classification of images in general and polarimetric synthetic aperture radar data in particular. While the majority of previous work focus on improving classification accuracy, we aim for accelerating the training of the classifier as well as its usage during prediction while maintaining its accuracy. Unlike other approaches we mainly consider algorithmic changes to stay as much as possible independent of platform and programming language. The final model achieves an approximately 60 times faster training and a 500 times faster prediction, while the accuracy is only marginally decreased by roughly 1 %.

Effect of gingival fluid on marginal adaptation of Class II resin-based composite restorations.

PubMed

Spahr, A; Schön, F; Haller, B

2000-10-01

To evaluate in vitro the marginal quality of Class II composite restorations at the gingival enamel margins as affected by contamination of the cavities with gingival fluid (GF) during different steps of resin bonding procedures. 70 Class II cavities were prepared in extracted human molars and restored with composite using a multi-component bonding system (OptiBond FL/Herculite XRV; OPTI) or a single-bottle adhesive (Syntac Sprint/Tetric Ceram; SYN). The cavities were contaminated with human GF: C1 after acid etching, C2 after application of the primer (OPTI) or light-curing of the primer-adhesive (SYN), and C3 after light-curing of the resin adhesive (OPTI). Uncontaminated cavities were used as the control (C0). The restored teeth were subjected to thermocycling (TC) and replicated for SEM analysis of marginal gap formation. Microleakage at the gingival margins was determined by dye penetration with basic fuchsin. non-parametric tests (Kruskal-Wallis test, Mann-Whitney test with Bonferroni correction). In both bonding systems, contamination with GF after acid etching (C1) did not impair the marginal quality; the mean percentages of continuous margin/mean depths of dye penetration were: OPTI: C0: 88.5%/0.10 mm, C1: 95.6%/0.04 mm; SYN: C0: 90.9%/0.08 mm, C1: 97.0%/0.05 mm. Marginal adaptation was adversely affected when GF contamination was performed after

Multiscale nonlinear microscopy and widefield white light imaging enables rapid histological imaging of surgical specimen margins

PubMed Central

Giacomelli, Michael G.; Yoshitake, Tadayuki; Cahill, Lucas C.; Vardeh, Hilde; Quintana, Liza M.; Faulkner-Jones, Beverly E.; Brooker, Jeff; Connolly, James L.; Fujimoto, James G.

2018-01-01

The ability to histologically assess surgical specimens in real-time is a long-standing challenge in cancer surgery, including applications such as breast conserving therapy (BCT). Up to 40% of women treated with BCT for breast cancer require a repeat surgery due to postoperative histological findings of close or positive surgical margins using conventional formalin fixed paraffin embedded histology. Imaging technologies such as nonlinear microscopy (NLM), combined with exogenous fluorophores can rapidly provide virtual H&E imaging of surgical specimens without requiring microtome sectioning, facilitating intraoperative assessment of margin status. However, the large volume of typical surgical excisions combined with the need for rapid assessment, make comprehensive cellular resolution margin assessment during surgery challenging. To address this limitation, we developed a multiscale, real-time microscope with variable magnification NLM and real-time, co-registered position display using a widefield white light imaging system. Margin assessment can be performed rapidly under operator guidance to image specific regions of interest located using widefield imaging. Using simulated surgical margins dissected from human breast excisions, we demonstrate that multi-centimeter margins can be comprehensively imaged at cellular resolution, enabling intraoperative margin assessment. These methods are consistent with pathology assessment performed using frozen section analysis (FSA), however NLM enables faster and more comprehensive assessment of surgical specimens because imaging can be performed without freezing and cryo-sectioning. Therefore, NLM methods have the potential to be applied to a wide range of intra-operative applications. PMID:29761001

Marginal Bone Loss Around Early-Loaded SLA and SLActive Implants: Radiological Follow-Up Evaluation Up to 6.5 Years.

PubMed

Şener-Yamaner, Işil Damla; Yamaner, Gökhan; Sertgöz, Atilla; Çanakçi, Cenk Fatih; Özcan, Mutlu

2017-08-01

The aim of this study was to compare marginal bone loss around early-loaded SLA and SLActive tissue-level implants (Straumann Dental Implants; Institut Straumann AG, Basel, Switzerland) after a mean of 81-month follow-up period. One hundred seven SLA and 68 SLActive implants were placed in 55 patients and loaded with final restoration after 8 and 3 weeks of healing time, respectively. Marginal bone loss around implants was determined radiographically at initial and after a mean observation time ranging between 20 and 81 months. The effect of location (mandible vs maxilla), smoking habit, sex, implant length and diameter, and the type of prosthesis on the marginal bone loss was evaluated. The overall cumulative survival rate was 98.2% being 99% for SLA implants and 97% for SLActive implants. After 20-month follow-up period, mean marginal bone loss values for the SLA and SLActive implants were 0.24 and 0.17 mm, respectively. After 81 months, mean marginal bone loss for the SLA and SLActive implants reached 0.71 and 0.53 mm, respectively. Marginal bone loss was affected by the length and type of implant and patients' smoking habit after a mean observation time of 20 months. However, none of the parameters had any significant effect on the marginal bone loss after a follow-up period of 81 months. With both SLA and SLActive implants, successful clinical results could be achieved up to 6.5 years of follow-up period.

Effect of flowable composite liner and glass ionomer liner on class II gingival marginal adaptation of direct composite restorations with different bonding strategies.

PubMed

Aggarwal, Vivek; Singla, Mamta; Yadav, Suman; Yadav, Harish

2014-05-01

The purpose of the present study was to comparatively evaluate the effect of flowable composite resin liner and resin modified glass ionomer liner on gingival marginal adaptation of class II cavities restored using three bonding agents (Single Bond 3M ESPE, One Coat Self Etching Bond Coltene Whaledent; Adper Easy Bond Self-Etch Adhesive 3M ESPE) and respective composite resins, under cyclic loading. The marginal adaptation was evaluated in terms of 'continuous margin' (CM) at the gingival margin. Ninety class II cavities with margins extending 1mm below the cement-enamel junction were prepared in extracted mandibular third molars. The samples were divided into three groups: no liner placement; 0.5-1mm thick flowable resin liner placement (Filtek Z350 XT flowable resin) on gingival floor and; light cure glass ionomer (Ketac N100) liner. The groups were further subdivided into three sub-groups on the basis of the bonding agents used. Cavities were restored with composite resins (Z350 for Single Bond and Adper Easy Bond; and Synergy D6 Universal, for One Coat Self Etching Bond) in 2mm increments and the samples were mechanically loaded (60N, 1,50,000 cycles). Marginal adaptation was evaluated using a low vacuum scanning electron microscope. Statistical analysis was done with two way ANOVA with Holm-Sidak's correction for multiple comparisons. Placement of flowable composite liner significantly improved the CM values of Single Bond (78±11%) and One Coat Self Etching Bond (77±9%) compared with no liner group, but the values of CM of Adper Easy Bond were not improved (61±12%). Placement of glass ionomer liner significantly improved the values of CM in all the sub-groups (78±9%, 72±10% and 77±10% for Single Bond, One Coat Self Etching Bond & Adper Easy Bond respectively) compared with no liner group. Placement of liners improved the values of 'continuous margin' in the gingival floor of the proximal cavities restored with composite resins using different bonding agent. Placement of flowable composite liner or glass ionomer liner will improve the marginal integrity of composite restorations using etch-and-rinse and two bottle-two step self etch adhesives. To improve the marginal integrity of a single bottle adhesive, glass ionomer liner should be applied. Copyright © 2014 Elsevier Ltd. All rights reserved.

Digital Timing Recovery for High Speed Optical Drives

NASA Astrophysics Data System (ADS)

Ko, Seok Jun; Kim, Pan Soo; Choi, Hyung Jin; Lee, Jae-Wook

2002-03-01

A new digital timing recovery scheme for the optical drive system is presented. By comparative simulations using digital versatile disc (DVD) patterns with marginal input conditions, the proposed algorithm shows enhanced performances in jitter variance and signal-to-noise ratio (SNR) margin by four times and 3 [dB], respectively.

A comparative evaluation of the marginal adaptation of a thermoplastic resin, a light cured wax and an inlay casting wax on stone dies: An in vitro study.

PubMed

Gopalan, Reji P; Nair, Vivek V; Harshakumar, K; Ravichandran, R; Lylajam, S; Viswambaran, Prasanth

2018-01-01

Different pattern materials do not produce copings with satisfactory, marginal accuracy when used on stone dies at varying time intervals. The purpose of this study was to evaluate and compare the vertical marginal accuracy of patterns formed from three materials, namely, thermoplastic resin, light cured wax and inlay casting wax at three-time intervals of 1, 12, and 24 h. A master die (zirconia abutment mimicking a prepared permanent maxillary central incisor) and metal sleeve (direct metal laser sintering crown #11) were fabricated. A total of 30 stone dies were obtained from the master die. Ten patterns were made each from the three materials and stored off the die at room temperature. The vertical marginal gaps were measured using digital microscope at 1, 12, and 24 h after reseating with gentle finger pressure. The results revealed a significant statistical difference in the marginal adaptation of three materials at all the three-time intervals. Light cured wax was found to be most accurate at all time intervals, followed by thermoplastic resin and inlay casting wax. Furthermore, there was a significant difference between all pairs of materials. The change in vertical marginal gap from 1 to 24 h between thermoplastic resin and light cured wax was not statistically significant. The marginal adaptation of all the three materials used, was well within the acceptable range of 25-70 μm. The resin pattern materials studied revealed significantly less dimensional change than inlay casting wax on storage at 1, 12, and 24 h time intervals. They may be employed in situations where high precision and delayed investing is expected.

Reduced change blindness suggests enhanced attention to detail in individuals with autism.

PubMed

Smith, Hayley; Milne, Elizabeth

2009-03-01

The phenomenon of change blindness illustrates that a limited number of items within the visual scene are attended to at any one time. It has been suggested that individuals with autism focus attention on less contextually relevant aspects of the visual scene, show superior perceptual discrimination and notice details which are often ignored by typical observers. In this study we investigated change blindness in autism by asking participants to detect continuity errors deliberately introduced into a short film. Whether the continuity errors involved central/marginal or social/non-social aspects of the visual scene was varied. Thirty adolescent participants, 15 with autistic spectrum disorder (ASD) and 15 typically developing (TD) controls participated. The participants with ASD detected significantly more errors than the TD participants. Both groups identified more errors involving central rather than marginal aspects of the scene, although this effect was larger in the TD participants. There was no difference in the number of social or non-social errors detected by either group of participants. In line with previous data suggesting an abnormally broad attentional spotlight and enhanced perceptual function in individuals with ASD, the results of this study suggest enhanced awareness of the visual scene in ASD. The results of this study could reflect superior top-down control of visual search in autism, enhanced perceptual function, or inefficient filtering of visual information in ASD.

A Singular Perturbation Approach for Time-Domain Assessment of Phase Margin

NASA Technical Reports Server (NTRS)

Zhu, J. Jim; Yang, Xiaojing; Hodel, A Scottedward

2010-01-01

This paper considers the problem of time-domain assessment of the Phase Margin (PM) of a Single Input Single Output (SISO) Linear Time-Invariant (LTI) system using a singular perturbation approach, where a SISO LTI fast loop system, whose phase lag increases monotonically with frequency, is introduced into the loop as a singular perturbation with a singular perturbation (time-scale separation) parameter Epsilon. First, a bijective relationship between the Singular Perturbation Margin (SPM) max and the PM of the nominal (slow) system is established with an approximation error on the order of Epsilon(exp 2). In proving this result, relationships between the singular perturbation parameter Epsilon, PM of the perturbed system, PM and SPM of the nominal system, and the (monotonically increasing) phase of the fast system are also revealed. These results make it possible to assess the PM of the nominal system in the time-domain for SISO LTI systems using the SPM with a standardized testing system called "PM-gauge," as demonstrated by examples. PM is a widely used stability margin for LTI control system design and certification. Unfortunately, it is not applicable to Linear Time-Varying (LTV) and Nonlinear Time-Varying (NLTV) systems. The approach developed here can be used to establish a theoretical as well as practical metric of stability margin for LTV and NLTV systems using a standardized SPM that is backward compatible with PM.

The Impact of Preradiation Residual Disease Volume on Time to Locoregional Failure in Cutaneous Merkel Cell Carcinoma—A TROG Substudy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finnigan, Renee; Hruby, George; Wratten, Chris

2013-05-01

Purpose: This study evaluated the impact of margin status and gross residual disease in patients treated with chemoradiation therapy for high-risk stage I and II Merkel cell cancer (MCC). Methods and Materials: Data were pooled from 3 prospective trials in which patients were treated with 50 Gy in 25 fractions to the primary lesion and draining lymph nodes and 2 schedules of carboplatin based chemotherapy. Time to locoregional failure was analyzed according to the burden of disease at the time of radiation therapy, comparing patients with negative margins, involved margins, or macroscopic disease. Results: Analysis was performed on 88 patients,more » of whom 9 had microscopically positive resection margins and 26 had macroscopic residual disease. The majority of gross disease was confined to nodal regions. The 5-year time to locoregional failure, time to distant failure, time to progression, and disease-specific survival rates for the whole group were 73%, 69%, 62%, and 66% respectively. The hazard ratio for macroscopic disease at the primary site or the nodes was 1.25 (95% confidence interval 0.57-2.77), P=.58. Conclusions: No statistically significant differences in time to locoregional failure were identified between patients with negative margins and those with microscopic or gross residual disease. These results must, however, be interpreted with caution because of the limited sample size.« less

Natural resources and their prospects in the closed basins of rift valley marginal grabens in northern Ethiopia

NASA Astrophysics Data System (ADS)

Meaza, Hailemariam; Frankl, Amaury; Poesen, Jean; Zenebe, Amanuel; Deckers, Jozef; Vaneetvelde, Veerle; Lanckriet, Sil; Nyssen, Jan

2016-04-01

With increasing population, producing more food and fibers has led to an expansion of the area under cultivation. For this, much attention is given to low-lying flat areas in search of suitable agricultural lands. The objectives of this paper are therefore: (1) to review the opportunities and challenges of natural resources in the marginal grabens for rural development; (2) to highlight the knowledge gaps and priorities in research and development in the marginal grabens, and (3) to supplement the literature review through repeat transect walks, focus group discussions and interviews across the western rift valley of northern Ethiopia. The paper shows that marginal grabens along the rift valleys are rich both in blue and green water resources due to their topographical and geological characteristics. Spate irrigation has been a growing water management practice to respond to soil moisture deficit. Besides, marginal grabens are fertile plains as a result of alluvial deposition that could be suitable for agricultural development. However, rainfall variability and groundwater withdrawal lead to graben basin closure and salinization. Notably, riverbed incisions and sediment deposition affects drainage systems and water supply in the marginal grabens. As a result, socioeconomic and natural capital of the marginal graben farmers are continuously threatened. Thus, the benefits of natural resources for rural development in the marginal grabens along the rift valley can be optimized if the current bottlenecks are converted into opportunities. A better understanding of the complex marginal graben system via a robust land evaluation framework will improve livelihoods of the communities that live in the (closed) marginal grabens. Keywords: population pressure, marginal grabens, endorheic lakes, salinization, Ethiopia

WZ Cygni: A Marginal Contact Binary in a Triple System?

NASA Astrophysics Data System (ADS)

Lee, Jae Woo; Kim, Seung-Lee; Lee, Chung-Uk; Kim, Ho-Il; Park, Jang-Ho; Hinse, Tobias Cornelius

2011-07-01

We present new multiband CCD photometry for WZ Cyg made on 22 nights in two observing seasons of 2007 and 2008. Our light-curve synthesis indicates that the system is in poor thermal contact with a fill-out factor of 4.8% and a temperature difference of 1447 K. Including our 40 timing measurements, a total of 371 times of minimum light spanning more than 112 yr were used for a period study. Detailed analysis of the O-C diagram showed that the orbital period has varied by a combination of an upward parabola and a sinusoid. The upward parabola means continuous period increase and indicates that some stellar masses are thermally transferred to the more massive primary star at a rate of about 5.80 × 10-8 M sun yr-1. The sinusoidal variation with a period of 47.9 yr and a semi-amplitude of 0.008 days can most likely be interpreted as the light-travel-time effect due to the existence of a low-mass M-type tertiary companion with a projected mass of M 3sin i 3 = 0.26 M sun. We examined the evolutionary status of WZ Cyg from the absolute dimensions of the eclipsing pair. It belongs to the marginal contact binary systems before the broken contact phase, consisting of a massive primary star with spectral type F4 and a secondary star with type K1.

Carbon Processing in Aquatic Critical Zones: A Source-to-Sink Perspective

NASA Astrophysics Data System (ADS)

Bianchi, T. S.

2017-12-01

The majority of organic carbon (OC) in the global ocean is buried in the coastal margin. In particular, river delta and non-deltaic shelf regions bury an estimated 114 Tg C year-1 and 70 Tg C year-1, respectively, with only ca. 6 Tg C year-1 buried in the open ocean. While there has long standing general agreement that continental selves represent the largest sink of both terrestrial (OCterr) and marine (OCmari) OC in the global ocean, our understanding of the spatial and temporal complexity of this region continues to evolve. For example, fjords are now more recognized as "hotspots"of carbon burial with recent estimates suggesting fjord surface area-normalized OC burial rates are at least five times greater than other marine systems and one hundred times greater than the entire ocean average. Here, I will compare and contrast some of the key molecular biomarkers that have been used to date to track OC across different depositional environments (e.g., large river deltas and fjords) and explore how margin-type, residence time of transport, reservoir dams, redox, priming effects, and molecular stability, impact the utility of using different biomarkers in coastal OC cycling. Finally, I will focus on important critical zones within the aquatic continuum from land-to-sea and examine how more attention is needed better understand OC cycling in these new dynamic interfaces in the Anthropocene.

Evaluation of marginal gap of Ni-Cr copings made with conventional and accelerated casting techniques.

PubMed

Tannamala, Pavan Kumar; Azhagarasan, Nagarasampatti Sivaprakasam; Shankar, K Chitra

2013-01-01

Conventional casting techniques following the manufacturers' recommendations are time consuming. Accelerated casting techniques have been reported, but their accuracy with base metal alloys has not been adequately studied. We measured the vertical marginal gap of nickel-chromium copings made by conventional and accelerated casting techniques and determined the clinical acceptability of the cast copings in this study. Experimental design, in vitro study, lab settings. Ten copings each were cast by conventional and accelerated casting techniques. All copings were identical, only their mold preparation schedules differed. Microscopic measurements were recorded at ×80 magnification on the perpendicular to the axial wall at four predetermined sites. The marginal gap values were evaluated by paired t test. The mean marginal gap by conventional technique (34.02 μm) is approximately 10 μm lesser than that of accelerated casting technique (44.62 μm). As the P value is less than 0.0001, there is highly significant difference between the two techniques with regard to vertical marginal gap. The accelerated casting technique is time saving and the marginal gap measured was within the clinically acceptable limits and could be an alternative to time-consuming conventional techniques.

A psychiatrist's role in “coming out” process: Context and controversies post-377

PubMed Central

Kalra, Gurvinder

2012-01-01

After the Delhi High Court judgment on reading down Section 377 Indian penal code, many individuals of alternate sexuality are wanting to come out to themselves and significant others in their lives. In this process, they often turn to psychiatrists seeking help. However the past of this specialty wherein homosexuality and other sexualities were considered a disease still haunts it with anecdotal reports of reorienting treatments continuing in certain parts of the country. While it is important to not continue with this unethical practice, at the same time, it is also important to be supportive to the issues that this and various other marginalized sexualities in our country face. This viewpoint is an attempt to reiterate certain steps that are to be followed by psychiatrists who find themselves in such clinical consultations. PMID:22556443

Phanerozoic tectonic evolution of the Circum-North Pacific

USGS Publications Warehouse

Nokleberg, Warren J.; Parfenov, Leonid M.; Monger, James W.H.; Norton, Ian O.; Khanchuk, Alexander I.; Stone, David B.; Scotese, Christopher R.; Scholl, David W.; Fujita, Kazuya

2000-01-01

The Phanerozoic tectonic evolution of the Circum-North Pacific is recorded mainly in the orogenic collages of the Circum-North Pacific mountain belts that separate the North Pacific from the eastern part of the North Asian Craton and the western part of the North American Craton. These collages consist of tectonostratigraphic terranes that are composed of fragments of igneous arcs, accretionary-wedge and subduction-zone complexes, passive continental margins, and cratons; they are overlapped by continental-margin-arc and sedimentary-basin assemblages. The geologic history of the terranes and overlap assemblages is highly complex because of postaccretionary dismemberment and translation during strike-slip faulting that occurred subparallel to continental margins.We analyze the complex tectonics of this region by the following steps. (1) We assign tectonic environments for the orogenic collages from regional compilation and synthesis of stratigraphic and faunal data. The types of tectonic environments include cratonal, passive continental margin, metamorphosed continental margin, continental-margin arc, island arc, oceanic crust, seamount, ophiolite, accretionary wedge, subduction zone, turbidite basin, and metamorphic. (2) We make correlations between terranes. (3) We group coeval terranes into a single tectonic origin, for example, a single island arc or subduction zone. (4) We group igneous-arc and subduction- zone terranes, which are interpreted as being tectonically linked, into coeval, curvilinear arc/subduction-zone complexes. (5) We interpret the original positions of terranes, using geologic, faunal, and paleomagnetic data. (6) We construct the paths of tectonic migration. Six processes overlapping in time were responsible for most of the complexities of the collage of terranes and overlap assemblages around the Circum-North Pacific, as follows. (1) During the Late Proterozoic, Late Devonian, and Early Carboniferous, major periods of rifting occurred along the ancestral margins of present-day Northeast Asia and northwestern North America. The rifting resulted in the fragmentation of each continent and the formation of cratonal and passive continental-margin terranes that eventually migrated and accreted to other sites along the evolving margins of the original or adjacent continents. (2) From about the Late Triassic through the mid-Cretaceous, a succession of island arcs and tectonically paired subduction zones formed near the continental margins. (3) From about mainly the mid-Cretaceous through the present, a succession of igneous arcs and tectonically paired subduction zones formed along the continental margins. (4) From about the Jurassic to the present, oblique convergence and rotations caused orogenparallel sinistral and then dextral displacements within the upper-plate margins of cratons that have become Northeast Asia and North America. The oblique convergences and rotations resulted in the fragmentation, displacement, and duplication of formerly more nearly continuous arcs, subduction zones, and passive continental margins. These fragments were subsequently accreted along the expanding continental margins. (5) From the Early Jurassic through Tertiary, movement of the upper continental plates toward subduction zones resulted in strong plate coupling and accretion of the former island arcs and subduction zones to the continental margins. Accretions were accompanied and followed by crustal thickening, anatexis, metamorphism, and uplift. The accretions resulted in substantial growth of the North Asian and North American Continents. (6) During the middle and late Cenozoic, oblique to orthogonal convergence of the Pacifi c plate with present-day Alaska and Northeast Asia resulted in formation of the modern-day ring of volcanoes around the Circum-North Pacific. Oblique convergence between the Pacific plate and Alaska also resulted in major dextral-slip faulting in interior and southern Alaska and along the western p

Re-appraisal of the Magma-rich versus Magma-poor Paradigm at Rifted Margins: consequences for breakup processes

NASA Astrophysics Data System (ADS)

Tugend, J.; Gillard, M.; Manatschal, G.; Nirrengarten, M.; Harkin, C. J.; Epin, M. E.; Sauter, D.; Autin, J.; Kusznir, N. J.; McDermott, K.

2017-12-01

Rifted margins are often classified based on their magmatic budget only. Magma-rich margins are commonly considered to have excess decompression melting at lithospheric breakup compared with steady state seafloor spreading while magma-poor margins have suppressed melting. New observations derived from high quality geophysical data sets and drill-hole data have revealed the diversity of rifted margin architecture and variable distribution of magmatism. Recent studies suggest, however, that rifted margins have more complex and polyphase tectono-magmatic evolutions than previously assumed and cannot be characterized based on the observed volume of magma alone. We compare the magmatic budget related to lithospheric breakup along two high-resolution long-offset deep reflection seismic profiles across the SE-Indian (magma-poor) and Uruguayan (magma-rich) rifted margins. Resolving the volume of magmatic additions is difficult. Interpretations are non-unique and several of them appear plausible for each case involving variable magmatic volumes and mechanisms to achieve lithospheric breakup. A supposedly 'magma-poor' rifted margin (SE-India) may show a 'magma-rich' lithospheric breakup whereas a 'magma-rich' rifted margin (Uruguay) does not necessarily show excess magmatism at lithospheric breakup compared with steady-state seafloor spreading. This questions the paradigm that rifted margins can be subdivided in either magma-poor or magma-rich margins. The Uruguayan and other magma-rich rifted margins appear characterized by an early onset of decompression melting relative to crustal breakup. For the converse, where the onset of decompression melting is late compared with the timing of crustal breakup, mantle exhumation can occur (e.g. SE-India). Our work highlights the difficulty in determining a magmatic budget at rifted margins based on seismic reflection data alone, showing the limitations of margin classification based solely on magmatic volumes. The timing of decompression melting onset and melting rates (magmatic processes) relative to crustal thinning (tectonic processes) appear equally, if not more important, than the magmatic budget for unravelling the evolution of rifted margins.

ARMA models for earthquake ground motions. Seismic safety margins research program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, M. K.; Kwiatkowski, J. W.; Nau, R. F.

1981-02-01

Four major California earthquake records were analyzed by use of a class of discrete linear time-domain processes commonly referred to as ARMA (Autoregressive/Moving-Average) models. It was possible to analyze these different earthquakes, identify the order of the appropriate ARMA model(s), estimate parameters, and test the residuals generated by these models. It was also possible to show the connections, similarities, and differences between the traditional continuous models (with parameter estimates based on spectral analyses) and the discrete models with parameters estimated by various maximum-likelihood techniques applied to digitized acceleration data in the time domain. The methodology proposed is suitable for simulatingmore » earthquake ground motions in the time domain, and appears to be easily adapted to serve as inputs for nonlinear discrete time models of structural motions. 60 references, 19 figures, 9 tables.« less

Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control.

PubMed

Maxwell, Jessica H; Thompson, Lester D R; Brandwein-Gensler, Margaret S; Weiss, Bernhard G; Canis, Martin; Purgina, Bibianna; Prabhu, Arpan V; Lai, Chi; Shuai, Yongli; Carroll, William R; Morlandt, Anthony; Duvvuri, Umamaheswar; Kim, Seungwon; Johnson, Jonas T; Ferris, Robert L; Seethala, Raja; Chiosea, Simion I

2015-12-01

Positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma (SCC). However, wide variation exists in the margin sampling technique. To determine the effect of the margin sampling technique on local recurrence (LR) in patients with stage I or II oral tongue SCC. A retrospective study was conducted from January 1, 1986, to December 31, 2012, in 5 tertiary care centers following tumor resection and elective neck dissection in 280 patients with pathologic (p)T1-2 pN0 oral tongue SCC. Analysis was conducted from June 1, 2013, to January 20, 2015. In group 1 (n = 119), tumor bed margins were not sampled. In group 2 (n = 61), margins were examined from the glossectomy specimen, found to be positive or suboptimal, and revised with additional tumor bed margins. In group 3 (n = 100), margins were primarily sampled from the tumor bed without preceding examination of the glossectomy specimen. The margin status (both as a binary [positive vs negative] and continuous [distance to the margin in millimeters] variable) and other clinicopathologic parameters were compared across the 3 groups and correlated with LR. Local recurrence. Age, sex, pT stage, lymphovascular or perineural invasion, and adjuvant radiation treatment were similar across the 3 groups. The probability of LR-free survival at 3 years was 0.9 and 0.8 in groups 1 and 3, respectively (P = .03). The frequency of positive glossectomy margins was lowest in group 1 (9 of 117 [7.7%]) compared with groups 2 and 3 (28 of 61 [45.9%] and 23 of 95 [24.2%], respectively) (P < .001). Even after excluding cases with positive margins, the median distance to the closest margin was significantly narrower in group 3 (2 mm) compared with group 1 (3 mm) (P = .008). The status (positive vs negative) of margins obtained from the glossectomy specimen correlated with LR (P = .007), while the status of tumor bed margins did not. The status of the tumor bed margin was 24% sensitive (95% CI, 16%-34%) and 92% specific (95% CI, 85%-97%) for detecting a positive glossectomy margin. The margin sampling technique affects local control in patients with oral tongue SCC. Reliance on margin sampling from the tumor bed is associated with worse local control, most likely owing to narrower margin clearance and greater incidence of positive margins. A resection specimen-based margin assessment is recommended.

Early Oral Tongue Squamous Cell Carcinoma Sampling of Margins From Tumor Bed and Worse Local Control

PubMed Central

Maxwell, Jessica H.; Thompson, Lester D. R.; Brandwein-Gensler, Margaret S.; Weiss, Bernhard G.; Canis, Martin; Purgina, Bibianna; Prabhu, Arpan V.; Lai, Chi; Shuai, Yongli; Carroll, William R.; Morlandt, Anthony; Duvvuri, Umamaheswar; Kim, Seungwon; Johnson, Jonas T.; Ferris, Robert L.; Seethala, Raja; Chiosea, Simion I.

2017-01-01

IMPORTANCE Positive margins are associated with poor prognosis among patients with oral tongue squamous cell carcinoma (SCC). However, wide variation exists in the margin sampling technique. OBJECTIVE To determine the effect of the margin sampling technique on local recurrence (LR) in patients with stage I or II oral tongue SCC. DESIGN, SETTING, AND PARTICIPANTS A retrospective study was conducted from January 1, 1986, to December 31, 2012, in 5 tertiary care centers following tumor resection and elective neck dissection in 280 patients with pathologic (p)T1-2 pN0 oral tongue SCC. Analysis was conducted from June 1, 2013, to January 20, 2015. INTERVENTIONS In group 1 (n = 119), tumor bed margins were not sampled. In group 2 (n = 61), margins were examined from the glossectomy specimen, found to be positive or suboptimal, and revised with additional tumor bed margins. In group 3 (n = 100), margins were primarily sampled from the tumor bed without preceding examination of the glossectomy specimen. The margin status (both as a binary [positive vs negative] and continuous [distance to the margin in millimeters] variable) and other clinicopathologic parameters were compared across the 3 groups and correlated with LR. MAIN OUTCOMES AND MEASURES Local recurrence. RESULTS Age, sex, pT stage, lymphovascular or perineural invasion, and adjuvant radiation treatment were similar across the 3 groups. The probability of LR-free survival at 3 years was 0.9 and 0.8 in groups 1 and 3, respectively (P = .03). The frequency of positive glossectomy margins was lowest in group 1 (9 of 117 [7.7%]) compared with groups 2 and 3 (28 of 61 [45.9%] and 23 of 95 [24.2%], respectively) (P < .001). Even after excluding cases with positive margins, the median distance to the closest margin was significantly narrower in group 3 (2 mm) compared with group 1 (3 mm) (P = .008). The status (positive vs negative) of margins obtained from the glossectomy specimen correlated with LR (P = .007), while the status of tumor bed margins did not. The status of the tumor bed margin was 24% sensitive (95% CI, 16%-34%) and 92% specific (95% CI, 85%-97%) for detecting a positive glossectomy margin. CONCLUSIONS AND RELEVANCE The margin sampling technique affects local control in patients with oral tongue SCC. Reliance on margin sampling from the tumor bed is associated with worse local control, most likely owing to narrower margin clearance and greater incidence of positive margins. A resection specimen–based margin assessment is recommended. PMID:26225798

Marginal Stability of Ion-Acoustic Waves in a Weakly Collisional Two-Temperature Plasma without a Current.

DTIC Science & Technology

1987-08-06

ABSTRACT (Continue on reverse if necessary and identify by block number) The linearized Balescu -Lenard-Poisson equations are solved in the weakly...free plasma is . unresolved. The purpose of this report is to present a resolution based upon the Balescu -Lenard-Poisson equations. The Balescu -Lenard...acoustic waves become marginally stable. Gur re- sults are based on the closed form solution for the dielectric function for the line- arized Balescu -Lenard

In Vitro Study Comparing the Marginal Leakage of Different Powder/Liquid Ratios of ZOE.

DTIC Science & Technology

1985-01-01

a Tarno FP hand instrument and the cavity was filled flush with the margin of the simulated endodontic access preparation cut in the amalgam... endodontic access preparations placed in tooth structure, as well as in amalgam anj composite resin. 0 Class V cavity preparations with a 90" cavosurface...opportunity to continue his education. Special thanks are expressed to Dr. Carl Newton, Chair- man of the Department of Endodontics and Director of

Multibeam mapping of the Los Angeles, California Margin

USGS Publications Warehouse

Gardner, James V.; Dartnell, Peter

2002-01-01

The Los Angeles, California Margin was mapped using multibeam echosounders during three separate surveys (Figure 1). In 1996, the USGS surveyed the shelf and slope in Santa Monica Bay from Pt. Dume to south of the Palos Verdes Peninsula. The mapping was accomplished using a Kongsberg Simrad EM1000 multibeam sonar system that provided high-quality bathymetry and quantitative backscatter. In 1998, the USGS continued the mapping to the south and surveyed the outer shelf, slope, and proximal basin off Long Beach and Newport using a Kongsberg Simrad EM300 multibeam sonar system. In 1999, the Los Angeles Margin mapping was completed with the surveying of the inner Long Beach shelf from the Palos Verdes Peninsula, south to Newport. This survey used a dual Kongsberg Simrad EM3000D multibeam sonar system. These three surveys were conducted to support USGS projects studying marine pollution and geohazards along the Los Angeles Margin.

Redox Effects on Organic Matter Storage in Coastal Sediments During the Holocene: A Biomarker/Proxy Perspective

NASA Astrophysics Data System (ADS)

Bianchi, Thomas S.; Schreiner, Kathryn M.; Smith, Richard W.; Burdige, David J.; Woodard, Stella; Conley, Daniel J.

2016-06-01

Coastal margins play a significant role in the burial of organic matter (OM) on Earth. These margins vary considerably with respect to their efficiency in OM burial and to the amounts and periodicity of their OM delivery, depending in large part on whether they are passive or active margins. In the context of global warming, these coastal regions are expected to experience higher water temperatures, changes in riverine inputs of OM, and sea level rise. Low-oxygen conditions continue to expand around the globe in estuarine regions (i.e., hypoxic zones) and shelf regions (i.e., oxygen minimum zones), which will impact the amounts and sources of OM stored in these regions. In this review, we explore how these changes are impacting the storage of OM and the preservation of sedimentary biomarkers, used as proxies to reconstruct environmental change, in coastal margins.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marousky, F.J.; Woltz, S.S.

The influence of soluble fluoride and a floral preservative (600 ppm 8-hydroxyquinoline citrate + 4% sucrose) on floret opening and quality of cut gladiolus was investigated using several cultivars. All cultivars evaluated showed distinct petal margin deterioration and necrosis at 1 ppm F. Many cultivars showed distinct petal margin discoloration and deterioration with accompanying bract and leaf margin deterioration in 4 days at 0.25 ppm fluoride. Colored flowering cultivars showed more fluoride injury than white or yellow flowering cultivars. Petal margin deterioration was most severe when spikes were continuously exposed to water containing fluoride. Florets on Victory spikes held inmore » water containing fluoride did not open as fully as those on spikes held in water. Floral preservative increased the number of open flowers and sustained floret quality. However, the preservative did not overcome the deleterious effects of fluoride in vase water. 13 references, 2 figures, 4 tables.« less

Determination of continuous variable entanglement by purity measurements.

PubMed

Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

2004-02-27

We classify the entanglement of two-mode Gaussian states according to their degree of total and partial mixedness. We derive exact bounds that determine maximally and minimally entangled states for fixed global and marginal purities. This characterization allows for an experimentally reliable estimate of continuous variable entanglement based on measurements of purity.

Dynamical criterion for a marginally unstable, quasi-linear behavior in a two-layer model

NASA Technical Reports Server (NTRS)

Ebisuzaki, W.

1988-01-01

A two-layer quasi-geostrophic flow forced by meridional variations in heating can be in regimes ranging from radiative equilibrium to forced geostrophic turbulence. Between these extremes is a regime where the time-mean (zonal) flow is marginally unstable. Using scaling arguments, it is concluded that such a marginally unstable state should occur when a certain parameter, measuring the strength of wave-wave interactions relative to the beta effect and advection by the thermal wind, is small. Numerical simulations support this proposal. A transition from the marginally unstable regime to a more nonlinear regime is then examined through numerical simulations with different radiative forcings. It is found that transition is not caused by secondary instability of waves in the marginally unstable regime. Instead, the time-mean flow can support a number of marginally unstable normal modes. These normal modes interact with each other, and if they are of sufficient amplitude, the flow enters a more nonlinear regime.

Transforming Ocean Sciences in the Northeast Pacific: NSF's Ocean Observatories Initiative Cabled Array is Now Operational

NASA Astrophysics Data System (ADS)

Kelley, D. S.

2016-02-01

In July-August, 2015 the first operations and maintenance cruise was successfully completed for the high power and bandwidth underwater cabled component of the National Science Foundation's Ocean Observatories Initiative: the Cabled Array. This system includes 900 km of backbone cable and 7 Primary Nodes, which provide 8 kW power and 10 Gbs bandwidth to myriad seafloor instruments (Manalang et al., this meeting) and instrumented full water column moorings (McRae et al., this meeting). Over 33,000 m of extension cables connected to 17 secondary junction boxes support >100 instruments now streaming data live to shore. In concert, this array forms: 1) the most advanced observatory along the global mid-ocean ridge network were 20 instruments and a state-of-the-art mooring system are providing new insights into volcanic and overlying water column processes at Axial Seamount (which erupted April 2015, see Delaney et al., this meeting); and 2) an extensive, technologically-advanced coastal observatory spanning 80 m to 2900 m water depths off Newport, OR. Here, cabled, instrumented moorings, with up to 18 instruments each, and associated seafloor arrays provide real-time, coregistered geophysical, biogeochemical, and physical measurements at unprecedented temporal and spatial resolution. Nearly 1.5 years of continuous data (see Knuth et al., this meeting), two-way communication capabilities that allow responses to events, and continuing real-time data flow, will allow the community to investigate in ways never before possible earthquakes along the Cascadia margin with impacts on fluid flow and release of methane into the hydrosphere, underwater eruptions resulting in perturbations to hydrothermal systems, associated biological communities, and overlying water column properties, and linkages among biogeochemical and physical processes along the Cascadia margin.

Time-varying nonstationary multivariate risk analysis using a dynamic Bayesian copula

NASA Astrophysics Data System (ADS)

Sarhadi, Ali; Burn, Donald H.; Concepción Ausín, María.; Wiper, Michael P.

2016-03-01

A time-varying risk analysis is proposed for an adaptive design framework in nonstationary conditions arising from climate change. A Bayesian, dynamic conditional copula is developed for modeling the time-varying dependence structure between mixed continuous and discrete multiattributes of multidimensional hydrometeorological phenomena. Joint Bayesian inference is carried out to fit the marginals and copula in an illustrative example using an adaptive, Gibbs Markov Chain Monte Carlo (MCMC) sampler. Posterior mean estimates and credible intervals are provided for the model parameters and the Deviance Information Criterion (DIC) is used to select the model that best captures different forms of nonstationarity over time. This study also introduces a fully Bayesian, time-varying joint return period for multivariate time-dependent risk analysis in nonstationary environments. The results demonstrate that the nature and the risk of extreme-climate multidimensional processes are changed over time under the impact of climate change, and accordingly the long-term decision making strategies should be updated based on the anomalies of the nonstationary environment.

Marginal revenue and length of stay in inpatient psychiatry.

PubMed

Pletscher, Mark

2016-09-01

This study examines the changes in marginal revenue during psychiatric inpatient stays in a large Swiss psychiatric hospital after the introduction of a mixed reimbursement system with tariff rates that vary over length of stay. A discrete time duration model with a difference-in-difference specification and time-varying coefficients is estimated to assess variations in policy effects over length of stay. Among patients whose costs are fully reimbursed by the mixed scheme, the model demonstrates a significant effect of marginal revenue on length of stay. No significant policy effects are found among patients for whom only health insurance rates are delivered as mixed tariffs and government contributions are made retrospectively. The results indicate that marginal revenue can affect length of stay in inpatient psychiatry facilities, but that the reduction in marginal revenue must be sufficiently large.

Recent changes to the Gulf Stream causing widespread gas hydrate destabilization.

PubMed

Phrampus, Benjamin J; Hornbach, Matthew J

2012-10-25

The Gulf Stream is an ocean current that modulates climate in the Northern Hemisphere by transporting warm waters from the Gulf of Mexico into the North Atlantic and Arctic oceans. A changing Gulf Stream has the potential to thaw and convert hundreds of gigatonnes of frozen methane hydrate trapped below the sea floor into methane gas, increasing the risk of slope failure and methane release. How the Gulf Stream changes with time and what effect these changes have on methane hydrate stability is unclear. Here, using seismic data combined with thermal models, we show that recent changes in intermediate-depth ocean temperature associated with the Gulf Stream are rapidly destabilizing methane hydrate along a broad swathe of the North American margin. The area of active hydrate destabilization covers at least 10,000 square kilometres of the United States eastern margin, and occurs in a region prone to kilometre-scale slope failures. Previous hypothetical studies postulated that an increase of five degrees Celsius in intermediate-depth ocean temperatures could release enough methane to explain extreme global warming events like the Palaeocene-Eocene thermal maximum (PETM) and trigger widespread ocean acidification. Our analysis suggests that changes in Gulf Stream flow or temperature within the past 5,000 years or so are warming the western North Atlantic margin by up to eight degrees Celsius and are now triggering the destabilization of 2.5 gigatonnes of methane hydrate (about 0.2 per cent of that required to cause the PETM). This destabilization extends along hundreds of kilometres of the margin and may continue for centuries. It is unlikely that the western North Atlantic margin is the only area experiencing changing ocean currents; our estimate of 2.5 gigatonnes of destabilizing methane hydrate may therefore represent only a fraction of the methane hydrate currently destabilizing globally. The transport from ocean to atmosphere of any methane released--and thus its impact on climate--remains uncertain.

Sedimentary processes on the northwestern Iberian continental margin viewed by long-range side-scan sonar and seismic data

USGS Publications Warehouse

Gardner, James V.; Kidd, Robert B.

1987-01-01

The effects of an eastern boundary current in the North Atlantic have been mapped from about 39° north latitude along the Iberian margin to as far north as 43°30 north latitude at the western margin of Galicia Bank. The geostrophic current has produced sediment drifts that are covered with bedforms. The sediment drifts are difficult to detect on Gloria long-range side-scan sonar data but are easily resolved on seismic-reflection records as anomalously thick accumulations of sediment banked against either buried or outcropping basement highs. The bedforms ornamenting the drift surfaces were subdivided into 1,000-m water-depth intervals, and their dimensions were tabulated. There are few bedforms in water depths less han 2,000 m, but from depths between 2,000 and 4,000 m they are numerous and have a mean wavelength of 695 m. Bedforms from depths greater than 4,000 m have a mean wavelength of 999 m. The different wavelengths from different water depths suggest two distinct and separated boundary flows. The wave heights of all bedforms found in water depths greater than 2,000 m are less than 10 m. In order to investigate the continuity of sediment drifting through geological time, the stratigraphic section drilled at DSDP Site 398 was reinterpreted and, using seismic-reflection profiles, was traced throughout the northern Iberian margin. Together, the lithostratigraphic and seismic data indicate that sediment drifting developed along this margin in the Eocene. The lithofacies of the Eocene section is t e oldest to have numerous layers of sand and silt. An unconformity separates the Eocene section from the latest Miocene-Pliocene section. The unconformity is interpreted to be the result of the initial pulses of Mediterranean outflow that followed the Messinian desiccation events. A second period of sediment drifting commenced during the Pliocene once the Mediterranean basin filled and the flow out of the Strait of Gibraltar resumed.

Co-ordination of growth, gas exchange and hydraulics define the carbon safety margin in tree species with contrasting drought strategies.

PubMed

Mitchell, P J; O'Grady, A P; Tissue, D T; Worledge, D; Pinkard, E A

2014-05-01

Gas exchange, growth, water transport and carbon (C) metabolism diminish during drought according to their respective sensitivities to declining water status. The timing of this sequence of declining physiological functions may determine how water and C relations compromise plant survival. In this paper, we test the hypothesis that the degree of asynchrony between declining C supply (photosynthesis) and C demand (growth and respiration) determines the rate and magnitude of changes in whole-plant non-structural carbohydrates (NSC) during drought. Two complementary experiments using two tree species (Eucalyptus globulus Labill. and Pinus radiata D. Don) with contrasting drought response strategies were performed to (i) assess changes in radial stem growth, transpiration, leaf water potential and gas exchange in response to chronic drought, and (ii) evaluate the concomitant impacts of these drought responses on the temporal patterns of NSC during terminal drought. The three distinct phases of water stress were delineated by thresholds of growth cessation and stomatal closure that defined the 'carbon safety margin' (i.e., the difference between leaf water potential when growth is zero and leaf water potential when net photosynthesis is zero). A wider C safety margin in E. globulus was defined by an earlier cessation of growth relative to photosynthesis that reduced the demand for NSC while maintaining C acquisition. By contrast, the narrower C safety margin in P. radiata was characterized by a synchronous decline in growth and photosynthesis, whereby growth continued under a declining supply of NSC from photosynthesis. The narrower C safety margin in P. radiata was associated with declines in starch concentrations after ∼ 90 days of chronic drought and significant depletion of starch in all organs at mortality. The observed divergence in the sensitivity of drought responses is indicative of a potential trade-off between maintaining hydraulic safety and adequate C availability. © The Author 2014. Published by Oxford University Press. All rights reserved.

The Canada Basin compared to the southwest South China Sea: Two marginal ocean basins with hyper-extended continent-ocean transitions

NASA Astrophysics Data System (ADS)

Li, Lu; Stephenson, Randell; Clift, Peter D.

2016-11-01

Both the Canada Basin (a sub-basin within the Amerasia Basin) and southwest (SW) South China Sea preserve oceanic spreading centres and adjacent passive continental margins characterized by broad COT zones with hyper-extended continental crust. We have investigated strain accommodation in the regions immediately adjacent to the oceanic spreading centres in these two basins using 2-D backstripping subsidence reconstructions, coupled with forward modelling constrained by estimates of upper crustal extensional faulting. Modelling is better constrained in the SW South China Sea but our results for the Canada Basin are analogous. Depth-dependent extension is required to explain the great depth of both basins because only modest upper crustal faulting is observed. A weak lower crust in the presence of high heat flow and, accordingly, a lower crust that extends far more the upper crust are suggested for both basins. Extension in the COT may have continued even after seafloor spreading has ceased. The analogous results for the two basins considered are discussed in terms of (1) constraining the timing and distribution of crustal thinning along the respective continental margins, (2) defining the processes leading to hyper-extension of continental crust in the respective tectonic settings and (3) illuminating the processes that control hyper-extension in these basins and more generally.

Evolution of Devonian carbonate-shelf margin, Nevada

USGS Publications Warehouse

Morrow, J.R.; Sandberg, C.A.

2008-01-01

The north-trending, 550-km-long Nevada segment of the Devonian carbonate-shelf margin, which fringed western North America, evidences the complex interaction of paleotectonics, eustasy, biotic changes, and bolide impact-related influences. Margin reconstruction is complicated by mid-Paleozoic to Paleogene compressional tectonics and younger extensional and strike-slip faulting. Reports published during the past three decades identify 12 important events that influenced development of shelf-margin settings; in chronological order, these are: (1) Early Devonian inheritance of Silurian stable shelf inargin, (2) formation of Early to early Middle 'Devonian shelf-margin basins, (3) propradation of later Middle Devonian shelf margin, (4) late Middle Devonian Taghanic ondap and continuing long-term Frasnian transgression, (5) initiation of latest Middle Devonian to early Frasnian proto-Antler orogenic forebulge, (6) mid-Frasnian Alamo Impact, (7) accelerated development of proto-Antler forebulge and backbulge Pilot basin, (8) global late Frasnian sentichatovae sea-level rise, (9) end-Frasnian sea-level fluctuations and ensuing mass extinction, (10) long-term Famennian regression and continept-wide erosion, (11) late Famennian emergence: of Ahtler orogenic highlands, and (12) end-Devonian eustatic sea-level fall. Although of considerable value for understanding facies relationships and geometries, existing standard carbonate platform-margin models developed for passive settings else-where do not adequately describe the diverse depositional and, structural settings along the Nevada Devonian platform margin. Recent structural and geochemical studies suggest that the Early to Middle Devonian-shelf-margin basins may have been fault-bound and controlled by inherited Precambrian structure. Subsequently, the migrating latest Middle to Late Devonian Antler orogenic forebulge exerted a dominant control on shelf-margin position, morphology, and sedimentation. ??Geological Society of America.

A Worst-Case Approach for On-Line Flutter Prediction

NASA Technical Reports Server (NTRS)

Lind, Rick C.; Brenner, Martin J.

1998-01-01

Worst-case flutter margins may be computed for a linear model with respect to a set of uncertainty operators using the structured singular value. This paper considers an on-line implementation to compute these robust margins in a flight test program. Uncertainty descriptions are updated at test points to account for unmodeled time-varying dynamics of the airplane by ensuring the robust model is not invalidated by measured flight data. Robust margins computed with respect to this uncertainty remain conservative to the changing dynamics throughout the flight. A simulation clearly demonstrates this method can improve the efficiency of flight testing by accurately predicting the flutter margin to improve safety while reducing the necessary flight time.

Dual-vergence structure from multiple migration of widely spaced OBSs

NASA Astrophysics Data System (ADS)

Yelisetti, Subbarao; Spence, George D.; Scherwath, Martin; Riedel, Michael; Klaeschen, Dirk

2017-10-01

The detailed structure of the northern Cascadia basin and frontal ridge region was obtained using data from several widely spaced ocean bottom seismometers (OBSs). Mirror imaging was used in which the downgoing multiples (mirror signal) are migrated as they provide information about a much larger area than imaging with primary signal alone. Specifically, Kirchhoff time migration was applied to hydrophone and vertical geophone data. Our results indicate remarkable structures that were not observed on the northern Cascadia margin in previous single-channel or multi-channel seismic (MCS) data. Results show that, in these water depths (2.0-2.5 km), an OBS can image up to 5 km on either side of its position on the seafloor and hence an OBS spacing of 5 km is sufficient to provide a two-fold migration stack. Results also show the top of the igneous oceanic crust at 5-6 km beneath the seafloor using only a small airgun source (120 in.3). Specifically, OBS migration results clearly show the continuity of reflectors which enabled the identification of frontal thrusts and a main thrust fault. These faults indicate, for the first time on this margin, the presence of a dual-vergence structure. These kinds of structures have so far been observed in < 0.5% of modern convergent margins and could be related to horizontal compression associated with subduction and low basal shear stress resulting from over-pressure. Reanalysis of previous MCS data from this region augmented the OBS migration results and further suggests that the vergence switches from seaward to landward around central Vancouver Island. Furthermore, fault geometry analyses indicate that the total amount of shortening accommodated due to faulting and folding is about 3 km, which suggest that thrusting would have started at least ∼ 65 ky ago.

A prolonged Cenozoic erosional period in East Kunlun (Western China): Constraints of detrital apatite (U-Th)/He ages on the onset of mountain building along the northern margin of the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Shi, Wenbei; Wang, Fei; Wu, Lin; Yang, Liekun; Zhang, Weibin; Wang, Yinzhi

2018-01-01

The timing of the development of the highland topography along the northern margin of the Tibetan Plateau is the key to understanding the manner of Tibetan growth and the far-field effects of the collision between India and Eurasia. Although various studies have investigated the exhumation and uplift of the basement rocks, thermochronological studies on the detritus from a continuous depositional sequence inan intermontane basin are lacking but might shed light on this issue. In this study, a set of detrital apatites from an upper Eocene to Pliocene depositional sequence in the Kumukol Basin, the largest intermontane basin in the East Kunlun, were dated by using the (U-Th)/He technique. The detrital apatites had consistent ages of ∼40 Ma for all deposit formations from bottom to top, which were older than the depositional ages. The ages and their consistency suggested that these detrital apatites were not reset and that the ages represented the original ages in the provenance region. These detrital apatite ages from the upper Eocene to Pliocene formations strongly suggested that the high mountains surrounding the Kumukol Basin formed at or before ∼40 Ma and have remained high since then. The process of mountain building resulted in a prolonged period of erosion from ∼40 to 2.6 Ma. The coupling of mountain and basin at ∼40 Ma was widespread along the East Kunlun. Our present results constrain the time of onset of the mountain building along the northern margin of the Tibetan Plateau, which may represent a rapid response to the India-Eurasian collision.

Real-time transrectal ultrasound guidance during laparoscopic radical prostatectomy: impact on surgical margins.

PubMed

Ukimura, Osamu; Magi-Galluzzi, Cristina; Gill, Inderbir S

2006-04-01

We evaluated whether intraoperative real-time TRUS navigation during LRP can decrease the incidence of positive surgical margins. Since March 2001, 294 patients with clinically organ confined prostate cancer undergoing LRP have been retrospectively divided into 2 groups, including group 1-217 who underwent LRP without TRUS from March 2001 to February 2003 and group 2-77 who have undergone LRP with TRUS since March 2003. Various baseline parameters were similar between the groups. Before March 2001 the senior surgeon had already performed more than 50 cases of LRP, thus, gaining reasonable familiarity with the technique. Compared to group 1, group 2 had a significantly decreased rate of positive surgical margins in patients with pT3 disease (57% vs 18%, p = 0.002). Positive margin rates also decreased in our overall experience (29% vs 9%, p = 0.0002). Intraoperative TRUS correctly predicted pT2 and pT3 disease in 85% and 86% of patients, respectively. Of the 54 TRUS visualized hypoechoic lesions at sites corresponding to biopsy proven cancer extracapsular extension was suspected in 31, leading to a real-time recommendation of calibrated wider, site specific dissection to achieve negative surgical margins. Intraoperative TRUS monitoring during LRP allows individualized, precise dissection tailored to the specific prostate contour anatomy, thus, compensating for the muted tactile feedback of laparoscopy. In what is to our knowledge the initial experience real-time TRUS guidance significantly decreased the incidence of positive surgical margins during LRP. In the future this concept of rectum based, intraoperative real-time navigation may facilitate a more sophisticated performance of radical prostatectomy.

Unconventional shallow biogenic gas systems

USGS Publications Warehouse

Shurr, G.W.; Ridgley, J.L.

2002-01-01

Unconventional shallow biogenic gas falls into two distinct systems that have different attributes. Early-generation systems have blanketlike geometries, and gas generation begins soon after deposition of reservoir and source rocks. Late-generation systems have ringlike geometries, and long time intervals separate deposition of reservoir and source rocks from gas generation. For both types of systems, the gas is dominantly methane and is associated with source rocks that are not thermally mature. Early-generation biogenic gas systems are typified by production from low-permeability Cretaceous rocks in the northern Great Plains of Alberta, Saskatchewan, and Montana. The main area of production is on the southeastern margin of the Alberta basin and the northwestern margin of the Williston basin. The huge volume of Cretaceous rocks has a generalized regional pattern of thick, non-marine, coarse clastics to the west and thinner, finer grained marine lithologies to the east. Reservoir rocks in the lower part tend to be finer grained and have lower porosity and permeability than those in the upper part. Similarly, source beds in the units have higher values of total organic carbon. Patterns of erosion, deposition, deformation, and production in both the upper and lower units are related to the geometry of lineament-bounded basement blocks. Geochemical studies show that gas and coproduced water are in equilibrium and that the fluids are relatively old, namely, as much as 66 Ma. Other examples of early-generation systems include Cretaceous clastic reservoirs on the southwestern margin of Williston basin and chalks on the eastern margin of the Denver basin. Late-generation biogenic gas systems have as an archetype the Devonian Antrim Shale on the northern margin of the Michigan basin. Reservoir rocks are fractured, organic-rich black shales that also serve as source rocks. Although fractures are important for production, the relationships to specific geologic structures are not clear. Large quantities of water are coproduced with the gas, and geochemical data indicate that the water is fairly fresh and relatively young. Current thinking holds that biogenic gas was generated, and perhaps continues to be, when glacial meltwater descended into the plumbing system provided by fractures. Other examples of late-generation systems include the Devonian New Albany Shale on the eastern margin of the Illinois basin and the Tertiary coalbed methane production on the northwestern margin of the Powder River basin. Both types of biogenic gas systems have a similar resource development history. Initially, little technology is used, and gas is consumed locally; eventually, sweet spots are exploited, widespread unconventional reservoirs are developed, and transport of gas is interstate or international. However, drilling and completion techniques are very different between the two types of systems. Early-generation systems have water-sensitive reservoir rocks, and consequently water is avoided or minimized in drilling and completion. In contrast, water is an important constituent of late-generation systems; gas production is closely tied to dewatering the system during production. Existing production and resource estimates generally range from 10 to 100 tcf for both types of biogenic gas systems. Although both system types are examples of relatively continuous accumulations, the geologic frameworks constrain most-economic production to large geologic structures on the margins of basins. Shallow biogenic gas systems hold important resources to meet the increased domestic and international demands for natural gas.

Geophysical reassessment of the role of ancient crustal structures on the development of western Laurentia and Selwyn Basin, Yukon and Northwest Territories, Canada.

NASA Astrophysics Data System (ADS)

Hayward, N.

2017-12-01

The structure of the western margin of the North American craton (Laurentia) in the northern Canadian Cordillera and its role in the development of the Neoproterozoic-Early Paleozoic Selwyn Basin are reassessed through 3D inversion of a new compilation of aeromagnetic data and archival Bouguer gravity data. The region's tectonic history is obscured by partial burial beneath Selwyn Basin, and a tectonic overprint that includes terrane accretion, regional plutonism, and strike-slip faults with displacements of 100s and perhaps 1000s of kilometers. Despite the implied complexity, preliminary geological and geophysical based interpretations of the structure of the western margin of Laurentia, have been adopted with few refinements in over two decades. Regionally continuous, NE-trending, crustal lineaments, including the Fort Norman line and Leith Ridge fault, were interpreted as having had long-standing influence on the craton development, its western margin, and overlapping sedimentary basin. New results reveal limited evidence for the regional continuity of the NE-trending lineaments. Instead, models suggest that the structure of the Laurentian margin is characterised by segmentation on numerous shorter structures of varied strike. The western margin of the craton and its structures are bound by a NW-trending structure that connects with the Richardson Trough to the north and may have been active during rifting of the Misty Creek embayment. This boundary also marks the easternmost limit of both granitic intrusions in Selwyn Basin, which gravity models suggest are of greater extent than reflected on geological maps, and SEDEX occurrences. An ENE-trending structure beneath northern Selwyn Basin is interpreted as marking the southern edge of a previously unidentified cratonic promontory, akin to the Liard line that marks a transfer fault that bounds the promontory of the Macdonald Platform, south of Selwyn Basin. The ENE-trending structure is traced from the Tintina fault in the west to near to the Great Bear magmatic zone. The structure's regional continuity also limits the interpretation of a post-Cretaceous structure, inboard of the Tintina fault that could be responsible for 1000's km of dextral strike-slip ascribed to the Baja-BC terrane translation model.

Perceived Marginalization and the Prediction of Romantic Relationship Stability

ERIC Educational Resources Information Center

Lehmiller, Justin J.; Agnew, Christopher R.

2007-01-01

The present research examined how perceived marginalization of one's romantic relationship is associated with level of future commitment to and stability of that involvement. Results from a 7-month longitudinal study of romantically involved individuals (N = 215) revealed that perceived social network marginalization at Time 1 predicted breakup…

Hypersonic vehicle model and control law development using H(infinity) and micron synthesis

NASA Astrophysics Data System (ADS)

Gregory, Irene M.; Chowdhry, Rajiv S.; McMinn, John D.; Shaughnessy, John D.

1994-10-01

The control system design for a Single Stage To Orbit (SSTO) air breathing vehicle will be central to a successful mission because a precise ascent trajectory will preserve narrow payload margins. The air breathing propulsion system requires the vehicle to fly roughly halfway around the Earth through atmospheric turbulence. The turbulence, the high sensitivity of the propulsion system to inlet flow conditions, the relatively large uncertainty of the parameters characterizing the vehicle, and continuous acceleration make the problem especially challenging. Adequate stability margins must be provided without sacrificing payload mass since payload margins are critical. Therefore, a multivariable control theory capable of explicitly including both uncertainty and performance is needed. The H(infinity) controller in general provides good robustness but can result in conservative solutions for practical problems involving structured uncertainty. Structured singular value mu framework for analysis and synthesis is potentially much less conservative and hence more appropriate for problems with tight margins. An SSTO control system requires: highly accurate tracking of velocity and altitude commands while limiting angle-of-attack oscillations, minimized control power usage, and a stabilized vehicle when atmospheric turbulence and system uncertainty are present. The controller designs using H(infinity) and mu-synthesis procedures were compared. An integrated flight/propulsion dynamic mathematical model of a conical accelerator vehicle was linearized as the vehicle accelerated through Mach 8. Vehicle acceleration through the selected flight condition gives rise to parametric variation that was modeled as a structured uncertainty. The mu-analysis approach was used in the frequency domain to conduct controller analysis and was confirmed by time history plots. Results demonstrate the inherent advantages of the mu framework for this class of problems.

Cone structure imaged with adaptive optics scanning laser ophthalmoscopy in eyes with nonneovascular age-related macular degeneration.

PubMed

Zayit-Soudry, Shiri; Duncan, Jacque L; Syed, Reema; Menghini, Moreno; Roorda, Austin J

2013-11-15

To evaluate cone spacing using adaptive optics scanning laser ophthalmoscopy (AOSLO) in eyes with nonneovascular AMD, and to correlate progression of AOSLO-derived cone measures with standard measures of macular structure. Adaptive optics scanning laser ophthalmoscopy images were obtained over 12 to 21 months from seven patients with AMD including four eyes with geographic atrophy (GA) and four eyes with drusen. Adaptive optics scanning laser ophthalmoscopy images were overlaid with color, infrared, and autofluorescence fundus photographs and spectral domain optical coherence tomography (SD-OCT) images to allow direct correlation of cone parameters with macular structure. Cone spacing was measured for each visit in selected regions including areas over drusen (n = 29), at GA margins (n = 14), and regions without drusen or GA (n = 13) and compared with normal, age-similar values. Adaptive optics scanning laser ophthalmoscopy imaging revealed continuous cone mosaics up to the GA edge and overlying drusen, although reduced cone reflectivity often resulted in hyporeflective AOSLO signals at these locations. Baseline cone spacing measures were normal in 13/13 unaffected regions, 26/28 drusen regions, and 12/14 GA margin regions. Although standard clinical measures showed progression of GA in all study eyes, cone spacing remained within normal ranges in most drusen regions and all GA margin regions. Adaptive optics scanning laser ophthalmoscopy provides adequate resolution for quantitative measurement of cone spacing at the margin of GA and over drusen in eyes with AMD. Although cone spacing was often normal at baseline and remained normal over time, these regions showed focal areas of decreased cone reflectivity. These findings may provide insight into the pathophysiology of AMD progression. (ClinicalTrials.gov number, NCT00254605).

Hypersonic vehicle model and control law development using H(infinity) and micron synthesis

NASA Technical Reports Server (NTRS)

Gregory, Irene M.; Chowdhry, Rajiv S.; Mcminn, John D.; Shaughnessy, John D.

1994-01-01

The control system design for a Single Stage To Orbit (SSTO) air breathing vehicle will be central to a successful mission because a precise ascent trajectory will preserve narrow payload margins. The air breathing propulsion system requires the vehicle to fly roughly halfway around the Earth through atmospheric turbulence. The turbulence, the high sensitivity of the propulsion system to inlet flow conditions, the relatively large uncertainty of the parameters characterizing the vehicle, and continuous acceleration make the problem especially challenging. Adequate stability margins must be provided without sacrificing payload mass since payload margins are critical. Therefore, a multivariable control theory capable of explicitly including both uncertainty and performance is needed. The H(infinity) controller in general provides good robustness but can result in conservative solutions for practical problems involving structured uncertainty. Structured singular value mu framework for analysis and synthesis is potentially much less conservative and hence more appropriate for problems with tight margins. An SSTO control system requires: highly accurate tracking of velocity and altitude commands while limiting angle-of-attack oscillations, minimized control power usage, and a stabilized vehicle when atmospheric turbulence and system uncertainty are present. The controller designs using H(infinity) and mu-synthesis procedures were compared. An integrated flight/propulsion dynamic mathematical model of a conical accelerator vehicle was linearized as the vehicle accelerated through Mach 8. Vehicle acceleration through the selected flight condition gives rise to parametric variation that was modeled as a structured uncertainty. The mu-analysis approach was used in the frequency domain to conduct controller analysis and was confirmed by time history plots. Results demonstrate the inherent advantages of the mu framework for this class of problems.

Multichannel Seismic Imaging of the Rivera Plate Subduction at the Seismogenic Jalisco Block Area (Western Mexican Margin)

NASA Astrophysics Data System (ADS)

Bartolome, R.; Gorriz, E.; Danobeitia, J.; Barba, D. C., Sr.; Martí, D.; L Cameselle, A.; Nuñez-Cornu, F. J.; Bandy, W. L.; Mortera, C.; Nunez, D.; Alonso, J. L.; Castellon, A.; Prada, M.

2016-12-01

During the TSUJAL marine geophysical survey, conducted in February and March 2014 Spanish, Mexican and British scientists and technicians explored the western margin of Mexico, considered one of the most active seismic zones in America. This work aims to characterize the internal structure of the subduction zone of the Rivera plate beneath the North American plate in the offshore part of the Jalisco Block, to link the geodynamic and the recent tectonic deformation occurring there with the possible generation of tsunamis and earthquakes. For this purpose, it has been carried out acquisition, processing and geological interpretation of a multichannel seismic reflection profile running perpendicular to the margin. Crustal images show an oceanic domain, dominated by subduction-accretion along the lower slope of the margin with a subparallel sediment thickness of up to 1.6 s two way travel time (approx. 2 km) in the Middle American Trench. Further, from these data the region appears to be prone to giant earthquake production. The top of the oceanic crust (intraplate reflector) is very well imaged. It is almost continuous along the profile with a gentle dip (<10°); however, it is disrupted by normal faulting resulting from the bending of the plate during subduction. The continental crust presents a well-developed accretionary prism consisting of highly deformed sediments with prominent slumping towards the trench that may be the result of past tsunamis. Also, a Bottom Simulating Reflector (BSR) is identified in the first half a second (twtt) of the section. High amplitude reflections at around 7-8 s twtt clearly image a discontinuous Moho, defining a very gentle dipping subduction plane.

Multichannel Seismic Imaging of the Rivera Plate Subduction at the Seismogenic Jalisco Block Area (Western Mexican Margin)

NASA Astrophysics Data System (ADS)

Bartolome, Rafael; Górriz, Estefanía; Dañobeitia, Juanjo; Cordoba, Diego; Martí, David; Cameselle, Alejandra L.; Núñez-Cornú, Francisco; Bandy, William L.; Mortera-Gutiérrez, Carlos A.; Nuñez, Diana; Castellón, Arturo; Alonso, Jose Luis

2016-10-01

During the TSUJAL marine geophysical survey, conducted in February and March 2014, Spanish, Mexican and British scientists and technicians explored the western margin of Mexico, considered one of the most active seismic zones in America. This work aims to characterize the internal structure of the subduction zone of the Rivera plate beneath the North American plate in the offshore part of the Jalisco Block, to link the geodynamic and the recent tectonic deformation occurring there with the possible generation of tsunamis and earthquakes. For this purpose, it has been carried out acquisition, processing and geological interpretation of a multichannel seismic reflection profile running perpendicular to the margin. Crustal images show an oceanic domain, dominated by subduction-accretion along the lower slope of the margin with a subparallel sediment thickness of up to 1.6 s two-way travel time (approx. 2 km) in the Middle American Trench. Further, from these data the region appears to be prone to giant earthquake production. The top of the oceanic crust (intraplate reflector) is very well imaged. It is almost continuous along the profile with a gentle dip (<10°); however, it is disrupted by normal faulting resulting from the bending of the plate during subduction. The continental crust presents a well-developed accretionary prism consisting of highly deformed sediments with prominent slumping towards the trench that may be the result of past tsunamis. Also, a bottom simulating reflector (BSR) is identified in the first half a second (twtt) of the section. High amplitude reflections at around 7-8 s twtt clearly image a discontinuous Moho, defining a very gentle dipping subduction plane.

Optimizing Survival of Patients With Marginally Operable Stage IIIA Non-Small-Cell Lung Cancer Receiving Chemoradiotherapy With or Without Surgery.

PubMed

Yang, Kai-Lin; Chang, Yih-Chen; Ko, Hui-Ling; Chi, Mau-Shin; Wang, Hsin-Ell; Hsu, Pei-Sung; Lin, Chen-Chun; Yeh, Diana Yu-Wung; Kao, Shang-Jyh; Jiang, Jiunn-Song; Chi, Kwan-Hwa

2016-11-01

For marginally operable stage IIIA non-small-cell lung cancer (NSCLC), surgery might not be done as planned after neoadjuvant concurrent chemoradiotherapy (CCRT) for reasons (unresectable or medically inoperable conditions, or patient refusal). This study aims to investigate the outcomes of a phased CCRT protocol established to maximize the operability of marginally operable stage IIIA NSCLC and to care for reassessed inoperable patients, in comparison with continuous-course definitive CCRT. Forty-seven patients with marginally operable stage IIIA NSCLC receiving CCRT were included. Twenty-eight patients were treated with our phased CCRT protocol, including neoadjuvant CCRT followed by surgery (group A, n = 16) or, for reassessed inoperable patients, maintenance chemotherapy and split-course CCRT boost (group B, n = 12). The other 19 were treated with continuous-course definitive CCRT (group C). Overall survival (OS) and progression-free survival (PFS) were analyzed. Among all, median OS and PFS were 35.6 and 12.8 months, respectively (median follow-up, 22.3 months). The median OS of group A (not reached) was better than that of group B (34.4 months) and group C (15.2 months) (P = .009). On multivariate analysis, performance status 0 to 1 (hazard ratio [HR], 0.026; P < .001), adenocarcinoma (HR, 0.156; P = .003), and group A (HR, 0.199; P = .033) were independent prognostic factors. The OS of group B (HR, 0.450; 95% confidence interval, 0.118-1.717; P = .243) was not statistically different from that of group C. For marginally operable stage IIIA NSCLC, our phased CCRT strategy may optimize survival by maximizing operability and maintain an acceptable survival for reassessed inoperable patients by split-course CCRT boost following maintenance chemotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

Dissolution of bedded rock salt: A seismic profile across the active eastern margin of the Hutchinson Salt Member, central Kansas

USGS Publications Warehouse

Anderson, N.L.; Hopkins, J.; Martinez, A.; Knapp, R.W.; Macfarlane, P.A.; Watney, W.L.; Black, R.

1994-01-01

Since late Tertiary, bedded rock salt of the Permian Hutchinson Salt Member has been dissolved more-or-less continuously along its active eastern margin in central Kansas as a result of sustained contact with unconfined, undersaturated groundwater. The associated westward migration of the eastern margin has resulted in surface subsidence and the contemporaneous sedimentation of predominantly valley-filling Quarternary alluvium. In places, these alluvium deposits extend more than 25 km to the east of the present-day edge of the main body of contiguous rock salt. The margin could have receded this distance during the past several million years. From an environmental perspective, the continued leaching of the Hutchinson Salt is a major concern. This predominantly natural dissolution occurs in a broad zone across the central part of the State and adversely affects groundwater and surface-water quality as nonpoint source pollution. Significant surface subsidence occurs as well. Most of these subsidence features have formed gradually; others developed in a more catastrophic manner. The latter in particular pose real threats to roadways, railways, and buried oil and gas pipelines. In an effort to further clarify the process of natural salt dissolution in central Kansas and with the long-term goal of mitigating the adverse environmental affects of such leaching, the Kansas Geological Survey acquired a 4-km seismic profile across the eastern margin of the Hutchinson Salt in the Punkin Center area of central Kansas. The interpretation of these seismic data (and supporting surficial and borehole geologic control) is consistent with several hypotheses regarding the process and mechanisms of dissolution. More specifically these data support the theses that: 1. (1) Dissolution along the active eastern margin of the Hutchinson Salt Member was initiated during late Tertiary. Leaching has resulted in the steady westward migration of the eastern margin, surface subsidence, and the contemporaneous deposition of predominantly valley-filling Quarternary alluvium. 2. (2) Along the active eastern margin, the rock salt has been leached vertically from the top down, and horizontally along the uppermost remnant bedded soluble layer(s). As a result, the eastern margin thickens gradually (up to 90 m) and in a stepwise manner from east to west for distances on the order 5-15 km. 3. (3) In places, the Hutchinson Salt Member has been leached locally along NNE-trending paleoshear zones situated to the west of the present-day edge of the main body of contiguous rock salt. Leaching at these sites initiated when the main dissolution front impinged upon preexisting shear zones. ?? 1994.

Heinrich events and sea level changes: records from uplifted coral terraces and marginal seas

NASA Astrophysics Data System (ADS)

Yokoyama, Y.; Esat, T. M.; Suga, H.; Obrochta, S.; Ohkouchi, N.

2017-12-01

Repeated major ice discharge events spaced every ca.7,000 years during the last ice age was first detected in deep sea sediments from North Atlantic. Characterized as lithic layers, these Heinrich Events (Heinrich, 1988 QR) correspond to rapid climate changes attributed to weakened ocean circulation (eg., Broecker, 1994 Nature; Alley, 1998 Nature) as shown by a number of different proxies. A better understanding of the overall picture of Heinrich events would benefit from determining the total amount of ice involved each event, which is still under debate. Sea level records are the most direct means for that, and uranium series dated corals can constrain the timing precisely. However, averaged global sea level during the time of interest was around -70m, hindering study from tectonically stable regions. Using uplifted coral terraces that extend 80 km along the Huon Peninsula, Papua New Guinea, the magnitude of sea level change during Heinrich Events was successfully reconstructed (Yokoyama et al., 2001 EPSL; Chappell et al., 1996 EPSL; Cutler et al., 2003). The H3 and H5 events are also well correlated with continuous sea level reconstructions using Red Sea oxygen isotope records (Siddall et al., 2003 Nature; Yokoyama and Esat, 2011Oceanography). Global ice sheet growth after 30 ka complicates interpretation of the Huon Peninsula record. However oxygen isotope data from the Japan Sea, a restricted margin sea with a shallow sill depth similar to the Red Sea, clearly captures the episode of H2 sea level change. The timing of these sea level excursions correlate well to the DSDP Site 609 detrital layers that are anchored in the latest Greenland ice core chronology (Obrochta et al., 2012 QSR). In the presentation, Antarctic ice sheet behavior during the H2 event will also be discussed using marginal seas oxygen records.

Incidence and location of positive surgical margin among open, laparoscopic and robot-assisted radical prostatectomy in prostate cancer patients: a single institutional analysis.

PubMed

Koizumi, Atsushi; Narita, Shintaro; Nara, Taketoshi; Takayama, Koichiro; Kanda, Sohei; Numakura, Kazuyuki; Tsuruta, Hiroshi; Maeno, Atsushi; Huang, Mingguo; Saito, Mitsuru; Inoue, Takamitsu; Tsuchiya, Norihiko; Satoh, Shigeru; Nanjo, Hiroshi; Habuchi, Tomonori

2018-06-19

To evaluate the positive surgical margin rates and locations in radical prostatectomy among three surgical approaches, including open radical prostatectomy, laparoscopic radical prostatectomy and robot-assisted radical prostatectomy. We retrospectively reviewed clinical outcomes at our institution of 450 patients who received radical prostatectomy. Multiple surgeons were involved in the three approaches, and a single pathologist conducted the histopathological diagnoses. Positive surgical margin rates and locations among the three approaches were statistically assessed, and the risk factors of positive surgical margin were analyzed. This study included 127, 136 and 187 patients in the open radical prostatectomy, laparoscopic radical prostatectomy and robot-assisted radical prostatectomy groups, respectively. The positive surgical margin rates were 27.6% (open radical prostatectomy), 18.4% (laparoscopic radical prostatectomy) and 13.4% (robot-assisted radical prostatectomy). In propensity score-matched analyses, the positive surgical margin rate in the robot-assisted radical prostatectomy was significantly lower than that in the open radical prostatectomy, whereas there was no significant difference in the positive surgical margin rates between robot-assisted radical prostatectomy and laparoscopic radical prostatectomy. In the multivariable analysis, PSA level at diagnosis and surgical approach (open radical prostatectomy vs robot-assisted radical prostatectomy) were independent risk factors for positive surgical margin. The apex was the most common location of positive surgical margin in the open radical prostatectomy and laparoscopic radical prostatectomy groups, whereas the bladder neck was the most common location in the robot-assisted radical prostatectomy group. The significant difference of positive surgical margin locations continued after the propensity score adjustment. Robot-assisted radical prostatectomy may potentially achieve the lowest positive surgical margin rate among three surgical approaches. The bladder neck was the most common location of positive surgical margin in robot-assisted radical prostatectomy and apex in open radical prostatectomy and laparoscopic radical prostatectomy. Although robot-assisted radical prostatectomy may contribute to the reduction of positive surgical margin, dissection of the bladder neck requires careful attention to avoid positive surgical margins.

Widespread methane leakage from the sea floor on the northern US Atlantic margin

USGS Publications Warehouse

Skarke, Adam; Ruppel, Carolyn; Kodis, Mali'o; Brothers, Daniel S.; Lobecker, Elizabeth A.

2014-01-01

Methane emissions from the sea floor affect methane inputs into the atmosphere, ocean acidification and de-oxygenation, the distribution of chemosynthetic communities and energy resources. Global methane flux from seabed cold seeps has only been estimated for continental shelves, at 8 to 65 Tg CH4 yr−1, yet other parts of marine continental margins are also emitting methane. The US Atlantic margin has not been considered an area of widespread seepage, with only three methane seeps recognized seaward of the shelf break. However, massive upper-slope seepage related to gas hydrate degradation has been predicted for the southern part of this margin, even though this process has previously only been recognized in the Arctic. Here we use multibeam water-column backscatter data that cover 94,000 km2 of sea floor to identify about 570 gas plumes at water depths between 50 and 1,700 m between Cape Hatteras and Georges Bank on the northern US Atlantic passive margin. About 440 seeps originate at water depths that bracket the updip limit for methane hydrate stability. Contemporary upper-slope seepage there may be triggered by ongoing warming of intermediate waters, but authigenic carbonates observed imply that emissions have continued for more than 1,000 years at some seeps. Extrapolating the upper-slope seep density on this margin to the global passive margin system, we suggest that tens of thousands of seeps could be discoverable.

Origin and late quaternary tectonism of a western Canadian continental shelf trough

NASA Astrophysics Data System (ADS)

Moslow, Thomas F.; Luternauer, John L.; Rohr, Kristin

1991-08-01

Analyses of high resolution and multi-channel seismic profiles from the central continental shelf of western Canada ascribe a late Quaternary glacial origin to large-scale troughs. Along the margins of Moresby Trough, one of three large-scale cross-shelf bathymetric depressions in Queen Charlotte Sound, seismic profiles within Quaternary sediments show a divergence of reflectors, thickening and folding of seismic units, and concavity of reflectors suggestive of drag. Compactional subsidence, growth faulting, and compaction faulting are also observed. Fault traces commonly terminate below the seabed. Deformation of Quaternary sediments due to faulting is plastic in nature and maximum offset of reflectors is 2.5 m. The observed Quaternary deformation appears to be a product of rapid deposition, loading and subsidence of late Quaternary sediment, which is unrelated to seismic activity. In addition, Quaternary faulting was probably activated by post-glacial loading and isostatic rebound of consolidated Tertiary strata along the margins of continental shelf troughs. The presence of mass movement (slump or debris flow) deposits overlying lithified Tertiary strata along the flanks of Moresby Trough provides the only evidence of seismic activity in the study area. The lack of a mud drape over these deposits implies a late Holocene age for the timing of their emplacement. The Quaternary troughs are incised into Tertiary-aged sedimentary fill of the Queen Charlotte basin. Previous workers had interpreted seafloor escarpments paralleling the trough margins to indicate that the location of Moresby Trough was controlled by renewed or continued activity on Tertiary-aged faults. A multi-channel seismic line across Moresby Trough shows that such an escarpment on the seafloor does not correlate to faults either in the Tertiary basin fill or the underlying basement. Tertiary reflectors are continuous underneath Moresby Trough; the seafloor escarpment is an erosional feature and was not created by reactivation of Tertiary structures. Trough erosion and subsequent fill (up to 175 m thick) are entirely of Quaternary age.

76 FR 4865 - Purified Carboxymethylcellulose From Mexico: Final Results of the First Five-Year (“Sunset...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

... likely lead to continuation or recurrence of dumping at the levels listed below in the section entitled... to CMC from Mexico would likely lead to a continuation or recurrence of dumping at the margins... to off-white, non-toxic, odorless, biodegradable powder, comprising sodium CMC that has been refined...

How Can Histograms Be Useful for Introducing Continuous Probability Distributions?

ERIC Educational Resources Information Center

Derouet, Charlotte; Parzysz, Bernard

2016-01-01

The teaching of probability has changed a great deal since the end of the last century. The development of technologies is indeed part of this evolution. In France, continuous probability distributions began to be studied in 2002 by scientific 12th graders, but this subject was marginal and appeared only as an application of integral calculus.…

Chirp seismic-reflection data from the Baltimore, Washington, and Norfolk Canyons, U.S. mid-Atlantic margin

USGS Publications Warehouse

Obelcz, Jeffrey B.; Brothers, Daniel S.; ten Brink, Uri S.; Chaytor, Jason D.; Worley, Charles R.; Moore, Eric M.

2014-01-01

A large number of high-resolution geophysical surveys between Cape Hatteras and Georges Bank have been conducted by federal, state, and academic institutions since the turn of the century. A major goal of these surveys is providing a continuous view of bathymetry and shallow stratigraphy at the shelf edge in order to assess levels of geological activity during the current sea level highstand. In 2012, chirp seismic-reflection data was collected by the U.S. Geologial Survey aboard the motor vessel Tiki XIV near three United States mid-Atlantic margin submarine canyons. These data can be used to further our understanding of passive continental margin processes during the Holocene, as well as providing valuable information regarding potential submarine geohazards.

Test and evaluation of the HIDEC engine uptrim algorithm

NASA Technical Reports Server (NTRS)

Ray, R. J.; Myers, L. P.

1986-01-01

The highly integrated digital electronic control (HIDEC) program will demonstrate and evaluate the improvements in performance and mission effectiveness that result from integrated engine-airframe control systems. Performance improvements will result from an adaptive engine stall margin mode, a highly integrated mode that uses the airplane flight conditions and the resulting inlet distortion to continuously compute engine stall margin. When there is excessive stall margin, the engine is uptrimmed for more thrust by increasing engine pressure ratio (EPR). The EPR uptrim logic has been evaluated and implemented into computer simulations. Thrust improvements over 10 percent are predicted for subsonic flight conditions. The EPR uptrim was successfully demonstrated during engine ground tests. Test results verify model predictions at the conditions tested.

Helicopter Flying Qualities Characteristics-CH-46E. Volume 1

DTIC Science & Technology

1983-10-03

STABILITY 54 6.0 CONTROL SENSITIVITY 61 . ° i CONTENTS (continued) Page 7.0 TIME HISTORY DATA 65 7.1 GENERAL 65 7.2 DYNAMIC STABILITY 65 7.3 CONTROL...The CH-46E meets these requirements by comfortable margins at the conditions tested. 61 NADC-81118-60 Volume 1 CH-46E (FRB, CONTROL IESPON!SE CH-46E...0 4.- ip L% t ,. _ 5" * ,.4 ••t, EFIGURE 7-5 I 7 ----- 1 FIU- - IA2 NADC-81118-6 Volume I-- .4 . > b in Zh. JI - ag4A 19-- O e t’ c 4 a I,- t

Quantitative measurement of marginal disintegration of ceramic inlays.

PubMed

Hayashi, Mikako; Tsubakimoto, Yuko; Takeshige, Fumio; Ebisu, Shigeyuki

2004-01-01

The objectives of this study include establishing a method for quantitative measurement of marginal change in ceramic inlays and clarifying their marginal disintegration in vivo. An accurate CCD optical laser scanner system was used for morphological measurement of the marginal change of ceramic inlays. The accuracy of the CCD measurement was assessed by comparing it with microscopic measurement. Replicas of 15 premolars restored with Class II ceramic inlays at the time of placement and eight years after restoration were used for morphological measurement by means of the CCD laser scanner system. Occlusal surfaces of the restored teeth were scanned and cross-sections of marginal areas were computed with software. Marginal change was defined as the area enclosed by two profiles obtained by superimposing two cross-sections of the same location at two different times and expressing the maximum depth and mean area of the area enclosed. The accuracy of this method of measurement was 4.3 +/- 3.2 microm in distance and 2.0 +/- 0.6% in area. Quantitative marginal changes for the eight-year period were 10 x 10 microm in depth and 50 x 10(3) microm2 in area at the functional cusp area and 7 x 10 microm in depth and 28 x 10(3) microm2 in area at the non-functional cusp area. Marginal disintegration at the functional cusp area was significantly greater than at the non-functional cusp area (Wilcoxon signed-ranks test, p < 0.05). This study constitutes a quantitative measurement of in vivo deterioration in marginal adaptation of ceramic inlays and indicates that occlusal force may accelerate marginal disintegration.

Global tectonic reconstructions with continuously deforming and evolving rigid plates

NASA Astrophysics Data System (ADS)

Gurnis, Michael; Yang, Ting; Cannon, John; Turner, Mark; Williams, Simon; Flament, Nicolas; Müller, R. Dietmar

2018-07-01

Traditional plate reconstruction methodologies do not allow for plate deformation to be considered. Here we present software to construct and visualize global tectonic reconstructions with deforming plates within the context of rigid plates. Both deforming and rigid plates are defined by continuously evolving polygons. The deforming regions are tessellated with triangular meshes such that either strain rate or cumulative strain can be followed. The finite strain history, crustal thickness and stretching factor of points within the deformation zones are tracked as Lagrangian points. Integrating these tools within the interactive platform GPlates enables specialized users to build and refine deforming plate models and integrate them with other models in time and space. We demonstrate the integrated platform with regional reconstructions of Cenozoic western North America, the Mesozoic South American Atlantic margin, and Cenozoic southeast Asia, embedded within global reconstructions, using different data and reconstruction strategies.

Principles and Guidelines for Duty and Rest Scheduling in Commercial Aviation

NASA Technical Reports Server (NTRS)

Dinges, David F.; Graeber, R. Curtis; Rosekind, Mark R.; Samel, Alexander

1996-01-01

The aviation industry requires 24-hour activities to meet operational demands. Growth in global long-haul, regional, overnight cargo, and short-haul domestic operations will continue to increase these round-the-clock requirements. Flight crews must be available to support 24-hour-a-day operations to meet these industry demands. Both domestic and international aviation can also require crossing multiple time zones. Therefore, shift work, night work, irregular work schedules, unpredictable work schedules, and dm zone changes will continue to be commonplace components of the aviation industry. These factors pose known challenges to human physiology, and because they result in performance-impairing fatigue, they pose a risk to safety. It is critical to acknowledge and, whenever possible, incorporate scientific information on fatigue, human sleep, and circadian physiology into 24-hour aviation operations. Utilization of such scientific information can help promote crew performance and alertness during flight operations and thereby maintain and improve the safety margin.

Targeted Maximum Likelihood Estimation for Dynamic and Static Longitudinal Marginal Structural Working Models

PubMed Central

Schwab, Joshua; Gruber, Susan; Blaser, Nello; Schomaker, Michael; van der Laan, Mark

2015-01-01

This paper describes a targeted maximum likelihood estimator (TMLE) for the parameters of longitudinal static and dynamic marginal structural models. We consider a longitudinal data structure consisting of baseline covariates, time-dependent intervention nodes, intermediate time-dependent covariates, and a possibly time-dependent outcome. The intervention nodes at each time point can include a binary treatment as well as a right-censoring indicator. Given a class of dynamic or static interventions, a marginal structural model is used to model the mean of the intervention-specific counterfactual outcome as a function of the intervention, time point, and possibly a subset of baseline covariates. Because the true shape of this function is rarely known, the marginal structural model is used as a working model. The causal quantity of interest is defined as the projection of the true function onto this working model. Iterated conditional expectation double robust estimators for marginal structural model parameters were previously proposed by Robins (2000, 2002) and Bang and Robins (2005). Here we build on this work and present a pooled TMLE for the parameters of marginal structural working models. We compare this pooled estimator to a stratified TMLE (Schnitzer et al. 2014) that is based on estimating the intervention-specific mean separately for each intervention of interest. The performance of the pooled TMLE is compared to the performance of the stratified TMLE and the performance of inverse probability weighted (IPW) estimators using simulations. Concepts are illustrated using an example in which the aim is to estimate the causal effect of delayed switch following immunological failure of first line antiretroviral therapy among HIV-infected patients. Data from the International Epidemiological Databases to Evaluate AIDS, Southern Africa are analyzed to investigate this question using both TML and IPW estimators. Our results demonstrate practical advantages of the pooled TMLE over an IPW estimator for working marginal structural models for survival, as well as cases in which the pooled TMLE is superior to its stratified counterpart. PMID:25909047

Recent technological developments: in situ histopathological interrogation of surgical tissues and resection margins

PubMed Central

Upile, Tahwinder; Fisher, Cyril; Jerjes, Waseem; El Maaytah, Mohammed; Singh, Sandeep; Sudhoff, Holger; Searle, Adam; Archer, Daniel; Michaels, Leslie; Hopper, Colin; Rhys-Evans, Peter; Howard, David; Wright, Anthony

2007-01-01

Objectives The tumour margin is an important surgical concept significantly affecting patient morbidity and mortality. We aimed in this prospective study to apply the microendoscope on tissue margins from patients undergoing surgery for oral cancer in vivo and ex vivo and compare it to the gold standard "paraffin wax", inter-observer agreement was measured; also to present the surgical pathologist with a practical guide to the every day use of the microendoscope both in the clinical and surgical fields. Materials and methods Forty patients undergoing resection of oral squamous cell carcinoma were recruited. The surgical margin was first marked by the operator followed by microendoscopic assessment. Biopsies were taken from areas suggestive of close or positive margins after microendoscopic examination. These histological samples were later scrutinized formally and the resection margins revisited accordingly when necessary. Results Using the microendoscope we report our experience in the determination of surgical margins at operation and later comparison with frozen section and paraffin section margins "gold standard". We were able to obtain a sensitivity of 95% and a specificity of 90%. Inter-observer Kappa scores comparing the microendoscope with formal histological analysis of normal and abnormal mucosa were 0.85. Conclusion The advantage of this technique is that a large area of mucosa can be sampled and any histomorphological changes can be visualized in real time allowing the operator to make important informed decisions with regards the intra-operative resection margin at the time of the surgery. PMID:17331229

Biogenic sedimentation beneath the California Current system for the past 30 kyr and its paleoceanographic significance

USGS Publications Warehouse

Gardner, J.V.; Dean, W.E.; Dartnell, P.

1997-01-01

A north-south transect of 17 cores was constructed along the eastern boundary of the California Current system from 33?? to 42?? N to investigate the changes in biogenic sedimentation over the past 30 kyr. Percentages and mass accumulation rates of CaCO3, Corg, and biogenic opal were assembled at 500 to 1000 years/sample to provide relatively high resolution. Time-space maps reveal a complex pattern of changes that do not follow a simple glacial-interglacial two-mode model. Biogenic sedimentation shows responses that are sometimes time-transgressive and sometimes coeval, and most of the responses show more consistency within a limited geographic area than any temporal consistency. Reconstructed conditions during late oxygen isotope stage 3 were more like early Holocene conditions than any other time during the last 30 kyr. Coastal upwelling and productivity during oxygen isotope stage 3 were relatively strong along the central California margin but were weak along the northern California margin. Precipitation increased during the last glacial interval in the central California region, and the waters of the southern California margin had relatively low productivity. Productivity on the southern Oregon margin was relatively low at the beginning of the last glacial interval, but by about 20 ka, productivity in this area significantly increased. This change suggests that the center of the divergence of the West Wind Drift shifted south at this time. The end of the last glacial interval was characterized by increased productivity in the southern California margin and increased upwelling along the central California margin but upwelling remained weak along the northern California margin. A sudden (<300 years) decrease in CaCO3, Corg, and biogenic opal occurred at 13 ka. The changes suggest a major reorientation of the atmospheric circulation in the North Pacific and western North America and the establishment of a strong seasonality in the central California region. A carbonate preservation event occurred at 10 ka that appears to reflect the uptake of CO2 by the terrestrial biosphere as the northern latitudes were reforested following retreat of the glaciers. The Holocene has been a period of relatively high productivity in the southern California margin, relatively strong coastal upwelling along the central California margin, relatively weak upwelling along the northern California margin, and the northward migration of the divergence zone of the West Wind Drift.

Real-Time Stability Margin Measurements for X-38 Robustness Analysis

NASA Technical Reports Server (NTRS)

Bosworth, John T.; Stachowiak, Susan J.

2005-01-01

A method has been developed for real-time stability margin measurement calculations. The method relies on a tailored-forced excitation targeted to a specific frequency range. Computation of the frequency response is matched to the specific frequencies contained in the excitation. A recursive Fourier transformation is used to make the method compatible with real-time calculation. The method was incorporated into the X-38 nonlinear simulation and applied to an X-38 robustness test. X-38 stability margins were calculated for different variations in aerodynamic and mass properties over the vehicle flight trajectory. The new method showed results comparable to more traditional stability analysis techniques, and at the same time, this new method provided coverage that is more complete and increased efficiency.

TH-CD-202-12: Online Inter-Beam Replanning Based On Real-Time Dose Reconstruction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kamerling, CP; Fast, MF; Ziegenhein, P

Purpose: This work provides a proof-of-concept study for online replanning during treatment delivery for step-and-shoot prostate SBRT, based on real-time dose reconstruction. Online replanning is expected to improve the trade-off between target coverage and organ-at-risk dose in the presence of intra-fractional motion. Methods: We have implemented an online replanning workflow on top of our previously reported real-time dose reconstruction software which connects to an Elekta research linac. The treatment planning system DynaPlan was extended to (1) re-optimize and sequence treatment plans (in clockwise beam order) before each beam, based on actual delivered dose, in a timeframe limited by the gantrymore » rotation between subsequent beams, and (2) send the respective segments to the delivery control software DynaTrack which starts/continues treatment immediately.To investigate the impact of a reduced safety margin, we have created and delivered (on a linac emulator) a conventional CTV+5/3mm (I) and a reduced CTV+1mm margin (II) treatment plan for a prostate patient. We have assessed CTV coverage with and without inter-beam replanning, all exposed to a gradual target shift of 0–5mm in posterior and inferior direction from start until the end of delivery. Results: For the reconstructed conventional plan (I), D98 for CTV was 100% of D98 of the planned dose. For the reconstructed margin-reduced plan (II), D98 for CTV was 95% of the planned D98 without replanning, but could be recovered to 99% by replanning for each beam. Plan (II) with replanning resulted in a decrease for bladder V90% by 88% and an increase to rectum V90% by 9% compared to the conventional plan (I). Dose calculation/accumulation was performed in <15ms per MLC aperture, replanning in <15s per beam. Conclusion: We have shown that online inter-beam replanning is technically feasible and potentially allows for a margin reduction. Future investigation considering motion-robust replanning optimization parameters is in progress. We acknowledge support of the MLC research from Elekta AB. This work is supported by Cancer Research UK under Programme C33589/A19908. Research at ICR is also supported by Cancer Research UK under Programme C33589/A19727 and NHS funding to the NIHR Biomedical Research Centre at RMH and ICR.« less

Kasei Valles Fractures

NASA Image and Video Library

2010-10-27

The fracture system shown in this image from NASA Mars Odyssey is on the northern margin of the Kasei Valles lowland. Fractures like this can become chaos with continued downdropping of blocks and widening fractures.

Prediction of Flutter Boundary Using Flutter Margin for The Discrete-Time System

NASA Astrophysics Data System (ADS)

Dwi Saputra, Angga; Wibawa Purabaya, R.

2018-04-01

Flutter testing in a wind tunnel is generally conducted at subcritical speeds to avoid damages. Hence, The flutter speed has to be predicted from the behavior some of its stability criteria estimated against the dynamic pressure or flight speed. Therefore, it is quite important for a reliable flutter prediction method to estimates flutter boundary. This paper summarizes the flutter testing of a wing cantilever model in a wind tunnel. The model has two degree of freedom; they are bending and torsion modes. The flutter test was conducted in a subsonic wind tunnel. The dynamic data responses was measured by two accelerometers that were mounted on leading edge and center of wing tip. The measurement was repeated while the wind speed increased. The dynamic responses were used to determine the parameter flutter margin for the discrete-time system. The flutter boundary of the model was estimated using extrapolation of the parameter flutter margin against the dynamic pressure. The parameter flutter margin for the discrete-time system has a better performance for flutter prediction than the modal parameters. A model with two degree freedom and experiencing classical flutter, the parameter flutter margin for the discrete-time system gives a satisfying result in prediction of flutter boundary on subsonic wind tunnel test.

Marginal Pricing and Student Investment in Higher Education

ERIC Educational Resources Information Center

Hemelt, Steven W.; Stange, Kevin M.

2016-01-01

This paper examines the effect of marginal price on students' educational investments using rich administrative data on students at Michigan public universities. Marginal price refers to the amount colleges charge for each additional credit taken in a semester. Institutions differ in how they price credits above the full-time minimum (of 12…

Area-Specific Marginal Costing for Electric Utilities: a Case Study of Transmission and Distribution Costs

NASA Astrophysics Data System (ADS)

Orans, Ren

1990-10-01

Existing procedures used to develop marginal costs for electric utilities were not designed for applications in an increasingly competitive market for electric power. The utility's value of receiving power, or the costs of selling power, however, depend on the exact location of the buyer or seller, the magnitude of the power and the period of time over which the power is used. Yet no electric utility in the United States has disaggregate marginal costs that reflect differences in costs due to the time, size or location of the load associated with their power or energy transactions. The existing marginal costing methods used by electric utilities were developed in response to the Public Utilities Regulatory Policy Act (PURPA) in 1978. The "ratemaking standards" (Title 1) established by PURPA were primarily concerned with the appropriate segmentation of total revenues to various classes-of-service, designing time-of-use rating periods, and the promotion of efficient long-term resource planning. By design, the methods were very simple and inexpensive to implement. Now, more than a decade later, the costing issues facing electric utilities are becoming increasingly complex, and the benefits of developing more specific marginal costs will outweigh the costs of developing this information in many cases. This research develops a framework for estimating total marginal costs that vary by the size, timing, and the location of changes in loads within an electric distribution system. To complement the existing work at the Electric Power Research Institute (EPRI) and Pacific Gas and Electric Company (PGandE) on estimating disaggregate generation and transmission capacity costs, this dissertation focuses on the estimation of distribution capacity costs. While the costing procedure is suitable for the estimation of total (generation, transmission and distribution) marginal costs, the empirical work focuses on the geographic disaggregation of marginal costs related to electric utility distribution investment. The study makes use of data from an actual distribution planning area, located within PGandE's service territory, to demonstrate the important characteristics of this new costing approach. The most significant result of this empirical work is that geographic differences in the cost of capacity in distribution systems can be as much as four times larger than the current system average utility estimates. Furthermore, lumpy capital investment patterns can lead to significant cost differences over time.

Plate tectonic evolution of the southern margin of Eurasia in the Mesozoic and Cenozoic

NASA Astrophysics Data System (ADS)

Golonka, J.

2004-03-01

Thirteen time interval maps were constructed, which depict the Triassic to Neogene plate tectonic configuration, paleogeography and general lithofacies of the southern margin of Eurasia. The aim of this paper is to provide an outline of the geodynamic evolution and position of the major tectonic elements of the area within a global framework. The Hercynian Orogeny was completed by the collision of Gondwana and Laurussia, whereas the Tethys Ocean formed the embayment between the Eurasian and Gondwanian branches of Pangea. During Late Triassic-Early Jurassic times, several microplates were sutured to the Eurasian margin, closing the Paleotethys Ocean. A Jurassic-Cretaceous north-dipping subduction boundary was developed along this new continental margin south of the Pontides, Transcaucasus and Iranian plates. The subduction zone trench-pulling effect caused rifting, creating the back-arc basin of the Greater Caucasus-proto South Caspian Sea, which achieved its maximum width during the Late Cretaceous. In the western Tethys, separation of Eurasia from Gondwana resulted in the formation of the Ligurian-Penninic-Pieniny-Magura Ocean (Alpine Tethys) as an extension of Middle Atlantic system and a part of the Pangean breakup tectonic system. During Late Jurassic-Early Cretaceous times, the Outer Carpathian rift developed. The opening of the western Black Sea occurred by rifting and drifting of the western-central Pontides away from the Moesian and Scythian platforms of Eurasia during the Early Cretaceous-Cenomanian. The latest Cretaceous-Paleogene was the time of the closure of the Ligurian-Pieniny Ocean. Adria-Alcapa terranes continued their northward movement during Eocene-Early Miocene times. Their oblique collision with the North European plate led to the development of the accretionary wedge of the Outer Carpathians and its foreland basin. The formation of the West Carpathian thrusts was completed by the Miocene. The thrust front was still propagating eastwards in the eastern Carpathians. During the Late Cretaceous, the Lesser Caucasus, Sanandaj-Sirjan and Makran plates were sutured to the Iranian-Afghanistan plates in the Caucasus-Caspian Sea area. A north-dipping subduction zone jumped during Paleogene to the Scythian-Turan Platform. The Shatski terrane moved northward, closing the Greater Caucasus Basin and opening the eastern Black Sea. The South Caspian underwent reorganization during Oligocene-Neogene times. The southwestern part of the South Caspian Basin was reopened, while the northwestern part was gradually reduced in size. The collision of India and the Lut plate with Eurasia caused the deformation of Central Asia and created a system of NW-SE wrench faults. The remnants of Jurassic-Cretaceous back-arc systems, oceanic and attenuated crust, as well as Tertiary oceanic and attenuated crust were locked between adjacent continental plates and orogenic systems.

Evolved dispersal strategies at range margins

PubMed Central

Dytham, Calvin

2009-01-01

Dispersal is a key component of a species's ecology and will be under different selection pressures in different parts of the range. For example, a long-distance dispersal strategy suitable for continuous habitat at the range core might not be favoured at the margin, where the habitat is sparse. Using a spatially explicit, individual-based, evolutionary simulation model, the dispersal strategies of an organism that has only one dispersal event in its lifetime, such as a plant or sessile animal, are considered. Within the model, removing habitat, increasing habitat turnover, increasing the cost of dispersal, reducing habitat quality or altering vital rates imposes range limits. In most cases, there is a clear change in the dispersal strategies across the range, although increasing death rate towards the margin has little impact on evolved dispersal strategy across the range. Habitat turnover, reduced birth rate and reduced habitat quality all increase evolved dispersal distances at the margin, while increased cost of dispersal and reduced habitat density lead to lower evolved dispersal distances at the margins. As climate change shifts suitable habitat poleward, species ranges will also start to shift, and it will be the dispersal capabilities of marginal populations, rather than core populations, that will influence the rate of range shifting. PMID:19324810

Constraints on Paleotsunami Runup Derived from Sand Deposits Mantling Three Holocene Marine Terraces at Puatai Beach, Northern Hikurangi Subduction Margin, New Zealand

NASA Astrophysics Data System (ADS)

Clark, K.; Litchfield, N. J.; Cochran, U. A.; Berryman, K. R.; Power, W. L.; Steele, R.

2016-12-01

At Puatai Beach, Gisborne, New Zealand, a 90-m-long continuous trench was excavated across a sequence of three marine terraces. The trench exposed the stratigraphy of deposits mantling the stepped shore platforms. The sequence of shelly sand and gravel beach deposits and silty colluvium allowed us to reconstruct the timing of earthquakes that uplifted the terraces, and place constraints on the age, runup and inundation distances of tsunamis that impacted the coastline in the late Holocene. Radiocarbon ages from shelly beach deposits lying on the platforms were used to date the terrace uplift ages at 1920-1650 (upper), 1270-1030 (middle), and 520-320 (lower) cal. yr BP respectively; we interpret these ages as the timing of large (M7+) paleoearthquakes on the nearshore Gable End Fault. With the inner edge of the highest shore platform reaching 9 m elevation, this flight of terraces has an average uplift rate of 5.6 ± 1 mm/yr, the highest uplift rate along the Hikurangi margin. The silty colluvium layers overlying the beach deposits contain thin semi-continuous sand layers. Based on chronological, geomorphological, sedimentological and biological considerations we suggest that at least some of these sand layers are tsunami deposits. Three sand layers were dated at 1190-930, 400-100, and 450-150 cal. yr BP, and the chronological overlap of the latter two suggests they could be the same event. Estimates of tsunami run-up were obtained from the surveyed maximum heights, and allowing for terrace uplift, they were 9.3 ± 0.5 m, 12.6 ± 0.5 m and 4.2-1.2 ± 0.5 m amsl, for the two dated and one un-dated paleotsunamis respectively; inundation distances were 58 m, 61 m, and 23 m. The inferred tsunami ages are slightly younger than the time of uplift of the marine terraces, and this, as well as their stratigraphic position within colluvium, suggests they were not necessarily triggered by rupture of the Gable End Fault. The younger ages potentially overlap tsunami deposits from nearby sites, and there are correlative paleotsunami deposits, uplift events, and turbidites from elsewhere along the Hikurangi Margin. Two tsunami earthquakes in 1947 offshore of Gisborne (25th March) and Tolaga Bay (17th May) caused tsunamis of 10 m and 6 m in height respectively, in this area but no geologic evidence of either tsunami was found at Puatai Beach.

High resolution 2D numerical models from rift to break-up: Crustal hyper-extension, Margin asymmetry, Sequential faulting

NASA Astrophysics Data System (ADS)

Brune, Sascha; Heine, Christian; Pérez-Gussinyé, Marta; Sobolev, Stephan

2013-04-01

Numerical modelling is a powerful tool to integrate a multitude of geological and geophysical data while addressing fundamental questions of passive margin formation such as the occurrence of crustal hyper-extension, (a-)symmetries between conjugate margin pairs, and the sometimes significant structural differences between adjacent margin segments. This study utilises knowledge gathered from two key examples of non-magmatic, asymmetric, conjugate margin pairs, i.e. Iberia-New Foundland and Southern Africa-Brazil, where many published seismic lines provide solid knowledge on individual margin geometry. While both margins involve crustal hyper-extension, it is much more pronounced in the South Atlantic. We investigate the evolution of these two margin pairs by carefully constraining our models with detailed plate kinematic history, laboratory-based rheology, and melt fraction evaluation of mantle upwelling. Our experiments are consistent with observed fault patterns, crustal thickness, and basin stratigraphy. We conduct 2D thermomechanical rift models using the finite element code SLIM3D that operates with nonlinear stress- and temperature-dependent elasto-visco-plastic rheology, with parameters provided by laboratory experiments on major crustal and upper mantle rocks. In our models we also calculate the melt fraction within the upwelling asthenosphere, which allows us to control whether the model indeed corresponds to the non-magmatic margin type or not. Our modelling highlights two processes as fundamental for the formation of hyper-extension and margin asymmetry at non-magmatic margins: (1) Strain hardening in the rift center due to cooling of upwelling mantle material (2) The formation of a weak crustal domain adjacent to the rift center caused by localized viscous strain softening and heat transfer from the mantle. Simultaneous activity of both processes promotes lateral rift migration in a continuous way that generates a wide layer of hyper-extended crust on one side of the rift basin. This mechanism implies that syn-rift deformation at the distal margin postdates faulting at the proximal margin by several million years. The succession of events holds intriguing implications not only for peak heat flow migration but also for processes like serpentinization and magmatic underplating.

17 CFR 242.504 - Notification to associated persons.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation Ac-Analyst Certification § 242.504 Notification to associated persons. A broker or dealer shall...

17 CFR 242.502 - Certifications in connection with public appearances.

Code of Federal Regulations, 2010 CFR

2010-04-01

... EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation Ac-Analyst Certification § 242.502 Certifications in connection with public...

17 CFR 242.101 - Activities by distribution participants.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation M § 242.101 Activities by distribution participants. (a) Unlawful Activity. In connection with a...

Core-seismic investigation of Surveyor Channel tributaries: Glacial history of the southern Alaskan margin

NASA Astrophysics Data System (ADS)

Somchat, K.; Reece, R.; Gulick, S. P. S.; Asahi, H.; Mix, A. C.

2016-12-01

The low angle subduction and collision of the Yakutat microplate with the North America Plate created, and continues to contribute to the uplift of the Chugach-St. Elias Range. This heavily glaciated, high topography proximal to the shoreline creates a unique source-to-sink system in which glacial sediment is transported and preserved offshore in a deep sea fan without much interruption. The product of this sediment is the Surveyor Fan and Channel system. Four tributary channels form the head of the Surveyor Channel complex and merge into the main channel trunk 200 km from the shelf edge. We integrate drill core and seismic reflection data to study the evolution of these tributaries in order to decipher glacial history of the southern Alaskan margin since the mid-Pleistocene (1.2 Ma). Updated age models from Integrated Ocean Drilling Program Expedition 341 Sites U1417 and U1418 provide a higher resolution chronology of sediment delivery to the Surveyor Fan than previous studies. We regionally extended the mapping of seismic subunits previously identified by Exp. 341 scientists at sites U1417 and U1418 and analyzed regional patterns of sediment deposition. Two-way travel time (isopach) maps of the three subunits show a trend of sediment depocenter shifting to the east since 1.2 Ma, where the Yakutat and Alsek tributaries have increasing sediment flux through time. Changes in sediment flux in each system represent the changes in locations and amplitudes of glacial ice over successive glacial intervals. Additionally, seismic analysis of channel geomorphology shows that each system contains distinct geomorphological evolutions. Since glacial erosion provides the sediment for the fan, the history of glacial ice onshore can be inferred from seismic geomorphology, where changes in glacial ice affect sediment supply and therefore shifts in depocenters and sedimentation pathways. This study shows an interaction between glacial activity onshore and deep sea fan sediment deposition and has implications for how glacial ice at high latitude margins can shape continental margins on a 100 kyr timescale.

NRC Continental Margins Workshop

NASA Astrophysics Data System (ADS)

Katsouros, Mary Hope

The Ocean Studies Board of the National Research Council is organizing a workshop, “Continental Margins: Evolution of Passive Continental Margins and Active Marginal Processes,” to stimulate discussion and longterm planning in the scientific community about the evolution of all types of continental margins. We want to coordinate academic, industry, and government agency efforts in this field, and to enhance communication between sea-based and land-based research programs.The continental margins constitute the only available record of the long-term dynamic interaction of oceanic and continental lithosphere. Of great interest are the unique structures and thick sedimentary sequences associated with this interaction. A major focus of the workshop will be to define strategies for exploring and understanding the continental margins in three dimensions and through geologic time. The workshop will be divided into 7 working groups, each concentrating on a major issue in continental margins research. A background document is being prepared summarizing recent research in specific continental margin fields and identifying key scientific and technical issues.

Insights into the origins of drumbeat earthquakes, periodic low frequency seismicity, and plug degradation from multi-instrument monitoring at Tungurahua volcano, Ecuador, April 2015

NASA Astrophysics Data System (ADS)

Bell, Andrew; Hernandez, Stephen; Gaunt, Elizabeth; Mothes, Patricia; Hidalgo, Silvana; Ruiz, Mario

2016-04-01

Highly-periodic repeating 'drumbeat' earthquakes have been reported from several andesitic and dacitic volcanoes. Physical models for the origin of drumbeat earthquakes incorporate, to different extents, the incremental upward movement of viscous magma. However, the roles played by stick-slip friction, brittle failure, and fluid flow, and the relations between drumbeat earthquakes and other low-frequency seismic signals, remain controversial. Here we report the results of analysis of three weeks of geophysical data recorded during an unrest episode at Tungurahua, an andesitic stratovolcano in Ecuador, during April 2015, by the monitoring network of the Instituto Geofisico of Ecuador. Combined seismic, geodetic, infrasound, and gas monitoring has provided new insights into the origins of periodic low-frequency seismic signals, conduit processes, and the nature of current unrest. Over the three-week period, the relative seismic amplitude (RSAM) correlated closely with short-term deformation rates and gas fluxes. However, the characteristics of the seismic signals, as recorded at a short-period station closest to the summit crater, changed considerably with time. Initially high RSAM and gas fluxes, with modest ash emissions, were associated with continuous and 'pulsed' tremor signals (amplitude modulated, with 30-100 second periods). As activity levels decreased over several days, tremor episodes became increasingly intermittent, and short-lived bursts of low-frequency earthquakes with quasiperiodic inter-event times were observed. Following one day of quiescence, the onset of pronounced low frequency drumbeat earthquakes signalled the resumption of elevated unrest, initially with mean inter-event times of 32 seconds, and later increasing to 74 seconds and longer, with periodicity progressively breaking down over several days. A reduction in RSAM was then followed by one week of persistent, quasiperiodic, longer-duration emergent low-frequency pulses, including 'double events'. The unrest finished with a series of minor explosions and ash emissions, and a reduction in RSAM. None of the seismic events were associated with significant infrasound or ground-coupled acoustic waves. The persistent and steadily evolving periodicity of seismic signals, and contemporaneous inflation-deflation tilt cycle, suggest that incremental upward movement of a viscous magma plug determines the system periodicity, likely controlled by the balance between magma ascent rate, magma compressibility beneath the plug, and resisting forces at the plug margin. However, relations between a range of observations, including waveform similarity, periodicity, and amplitudes of contemporaneous discrete and continuous signals, suggest that the detected seismic signals are predominantly generated by gas flow that is largely decoupled from the magma ascent rate. Signals are generated by both continuous flow through longer-lived pathways, and by gas pulses passing through transient pathways generated by slip at the plug margins. The nature and amplitude of signals is therefore a product of the rate of gas flux and the evolving state of the degassing pathway, controlled in part by degradation and healing of the plug margins.

Time Domain Stability Margin Assessment Method

NASA Technical Reports Server (NTRS)

Clements, Keith

2017-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

Time-Domain Stability Margin Assessment

NASA Technical Reports Server (NTRS)

Clements, Keith

2016-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

Environmental Popular Education and Indigenous Social Movements in India.

ERIC Educational Resources Information Center

Kapoor, Dip

2003-01-01

Environmental popular education helps shape indigenous social movements in India through a continual process of reflection and action that connects concerns about ecological degradation, subsistence, and marginalization. (Contains 56 references.) (SK)

Post-processing of multi-model ensemble river discharge forecasts using censored EMOS

NASA Astrophysics Data System (ADS)

Hemri, Stephan; Lisniak, Dmytro; Klein, Bastian

2014-05-01

When forecasting water levels and river discharge, ensemble weather forecasts are used as meteorological input to hydrologic process models. As hydrologic models are imperfect and the input ensembles tend to be biased and underdispersed, the output ensemble forecasts for river runoff typically are biased and underdispersed, too. Thus, statistical post-processing is required in order to achieve calibrated and sharp predictions. Standard post-processing methods such as Ensemble Model Output Statistics (EMOS) that have their origins in meteorological forecasting are now increasingly being used in hydrologic applications. Here we consider two sub-catchments of River Rhine, for which the forecasting system of the Federal Institute of Hydrology (BfG) uses runoff data that are censored below predefined thresholds. To address this methodological challenge, we develop a censored EMOS method that is tailored to such data. The censored EMOS forecast distribution can be understood as a mixture of a point mass at the censoring threshold and a continuous part based on a truncated normal distribution. Parameter estimates of the censored EMOS model are obtained by minimizing the Continuous Ranked Probability Score (CRPS) over the training dataset. Model fitting on Box-Cox transformed data allows us to take account of the positive skewness of river discharge distributions. In order to achieve realistic forecast scenarios over an entire range of lead-times, there is a need for multivariate extensions. To this end, we smooth the marginal parameter estimates over lead-times. In order to obtain realistic scenarios of discharge evolution over time, the marginal distributions have to be linked with each other. To this end, the multivariate dependence structure can either be adopted from the raw ensemble like in Ensemble Copula Coupling (ECC), or be estimated from observations in a training period. The censored EMOS model has been applied to multi-model ensemble forecasts issued on a daily basis over a period of three years. For the two catchments considered, this resulted in well calibrated and sharp forecast distributions over all lead-times from 1 to 114 h. Training observations tended to be better indicators for the dependence structure than the raw ensemble.

A comparative evaluation of the marginal accuracy of crowns fabricated from four commercially available provisional materials: An in vitro study

PubMed Central

Amin, Bhavya Mohandas; Aras, Meena Ajay; Chitre, Vidya

2015-01-01

Purpose: The purpose of this in vitro study was to evaluate and compare the primary marginal accuracy of four commercially available provisional materials (Protemp 4, Luxatemp Star, Visalys Temp and DPI tooth moulding powder and liquid) at 2 time intervals (10 and 30 min). Materials and Methods: A customized stainless steel master model containing two interchangeable dies was used for fabrication of provisional crowns. Forty crowns (n = 10) were fabricated, and each crown was evaluated under a stereomicroscope. Vertical marginal discrepancies were noted and compared at 10 min since the start of mixing and then at 30 min. Observations and Results: Protemp 4 showed the least vertical marginal discrepancy (71.59 μ), followed by Luxatemp Star (91.93 μ) at 10 min. DPI showed a marginal discrepancy of 95.94 μ while Visalys Temp crowns had vertical marginal discrepancy of 106.81 μ. There was a significant difference in the marginal discrepancy values of Protemp 4 and Visalys Temp. At 30 min, there was a significant difference between the marginal discrepancy of Protemp 4 crowns (83.11 μ) and Visalys Temp crowns (128.97 μ) and between Protemp 4 and DPI (118.88 μ). No significant differences were observed between Protemp 4 and Luxatemp Star. Conclusion: The vertical marginal discrepancy of temporary crowns fabricated from the four commercially available provisional materials ranged from 71 to 106 μ immediately after fabrication (at 10 min from the start of mix) to 83–128 μ (30 min from the start of mix). The time elapsed after mixing had a significant influence on the marginal accuracy of the crowns. PMID:26097348

Extremal entanglement and mixedness in continuous variable systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

2004-08-01

We investigate the relationship between mixedness and entanglement for Gaussian states of continuous variable systems. We introduce generalized entropies based on Schatten p norms to quantify the mixedness of a state and derive their explicit expressions in terms of symplectic spectra. We compare the hierarchies of mixedness provided by such measures with the one provided by the purity (defined as tr {rho}{sup 2} for the state {rho}) for generic n-mode states. We then review the analysis proving the existence of both maximally and minimally entangled states at given global and marginal purities, with the entanglement quantified by the logarithmic negativity.more » Based on these results, we extend such an analysis to generalized entropies, introducing and fully characterizing maximally and minimally entangled states for given global and local generalized entropies. We compare the different roles played by the purity and by the generalized p entropies in quantifying the entanglement and the mixedness of continuous variable systems. We introduce the concept of average logarithmic negativity, showing that it allows a reliable quantitative estimate of continuous variable entanglement by direct measurements of global and marginal generalized p entropies.« less

Alarms based on real-time sensor glucose values alert patients to hypo- and hyperglycemia: the guardian continuous monitoring system.

PubMed

Bode, Bruce; Gross, Kenneth; Rikalo, Nancy; Schwartz, Sherwyn; Wahl, Timothy; Page, Casey; Gross, Todd; Mastrototaro, John

2004-04-01

The purposes of this study were to demonstrate the accuracy and effectiveness of the Guardian Continuous Monitoring System (Medtronic MiniMed, Northridge, California) and to demonstrate that the application of real-time alarms to continuous monitoring alerts users to hypo and hyperglycemia and reduces excursions in people with diabetes. A total of 71 subjects with type 1 diabetes, mean hemoglobin A1c of 7.6 +/- 1.1%, age 44.0 +/- 11.4 years, and duration of diabetes 23.6 +/- 10.6 years were enrolled in this two-period, randomized, multicenter study. Subjects were randomized into either an Alert group or a Control group. The accuracy of the Guardian was evaluated by treating the study data as a single-sample correlational design. Effectiveness of the Guardian alerts was evaluated by comparing the Alert group with the Control group. The mean (median) absolute relative error between home blood glucose meter readings and sensor values was 21.3% (17.3%), and the Guardian, on average, read 12.8 mg/dL below the concurrent home blood glucose meter readings. The hypoglycemia alert was able to distinguished glucose values < or =70 mg/dL with 67% sensitivity, 90% specificity, and 47% false alerts. The hyperglycemia alert showed a similar ability to detect sensor values > or =250 mg/dL with 63% sensitivity, 97% specificity, and 19% false alerts. The Alert group demonstrated a median decrease in the duration of hypoglycemic excursions (-27.8 min) that was significantly greater than the median decrease in the duration of hypoglycemic excursions in the Control group (-4.5 min) (P = 0.03). A marginally significant increase in the frequency of hyperglycemic excursions (P = 0.07) between Period 1 and Period 2 was accompanied by a decrease of 9.6 min in the duration of hyperglycemic excursions in the Alert group. Glucose measurements differ between blood samples taken from the finger and interstitial fluid, especially when levels are changing rapidly; however, these results demonstrate that the Guardian is reasonably accurate while performing continuous glucose monitoring. The subjects' responses to hypoglycemia alerts resulted in a significant reduction in the duration of hypoglycemic excursions; however, overtreating hypoglycemia may have resulted in a marginally significant increase in the frequency of hyperglycemic excursions.

Encoding of marginal utility across time in the human brain.

PubMed

Pine, Alex; Seymour, Ben; Roiser, Jonathan P; Bossaerts, Peter; Friston, Karl J; Curran, H Valerie; Dolan, Raymond J

2009-07-29

Marginal utility theory prescribes the relationship between the objective property of the magnitude of rewards and their subjective value. Despite its pervasive influence, however, there is remarkably little direct empirical evidence for such a theory of value, let alone of its neurobiological basis. We show that human preferences in an intertemporal choice task are best described by a model that integrates marginally diminishing utility with temporal discounting. Using functional magnetic resonance imaging, we show that activity in the dorsal striatum encodes both the marginal utility of rewards, over and above that which can be described by their magnitude alone, and the discounting associated with increasing time. In addition, our data show that dorsal striatum may be involved in integrating subjective valuation systems inherent to time and magnitude, thereby providing an overall metric of value used to guide choice behavior. Furthermore, during choice, we show that anterior cingulate activity correlates with the degree of difficulty associated with dissonance between value and time. Our data support an integrative architecture for decision making, revealing the neural representation of distinct subcomponents of value that may contribute to impulsivity and decisiveness.

Verifiable Adaptive Control with Analytical Stability Margins by Optimal Control Modification

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.

2010-01-01

This paper presents a verifiable model-reference adaptive control method based on an optimal control formulation for linear uncertain systems. A predictor model is formulated to enable a parameter estimation of the system parametric uncertainty. The adaptation is based on both the tracking error and predictor error. Using a singular perturbation argument, it can be shown that the closed-loop system tends to a linear time invariant model asymptotically under an assumption of fast adaptation. A stability margin analysis is given to estimate a lower bound of the time delay margin using a matrix measure method. Using this analytical method, the free design parameter n of the optimal control modification adaptive law can be determined to meet a specification of stability margin for verification purposes.

Test and evaluation of the HIDEC engine uptrim algorithm. [Highly Integrated Digital Electronic Control for aircraft

NASA Technical Reports Server (NTRS)

Ray, R. J.; Myers, L. P.

1986-01-01

The highly integrated digital electronic control (HIDEC) program will demonstrate and evaluate the improvements in performance and mission effectiveness that result from integrated engine-airframe control systems. Performance improvements will result from an adaptive engine stall margin mode, a highly integrated mode that uses the airplane flight conditions and the resulting inlet distortion to continuously compute engine stall margin. When there is excessive stall margin, the engine is uptrimmed for more thrust by increasing engine pressure ratio (EPR). The EPR uptrim logic has been evaluated and implemente into computer simulations. Thrust improvements over 10 percent are predicted for subsonic flight conditions. The EPR uptrim was successfully demonstrated during engine ground tests. Test results verify model predictions at the conditions tested.

A joint model of persistent human papillomavirus infection and cervical cancer risk: Implications for cervical cancer screening

PubMed Central

Katki, Hormuzd A.; Cheung, Li C.; Fetterman, Barbara; Castle, Philip E.; Sundaram, Rajeshwari

2014-01-01

Summary New cervical cancer screening guidelines in the US and many European countries recommend that women get tested for human papillomavirus (HPV). To inform decisions about screening intervals, we calculate the increase in precancer/cancer risk per year of continued HPV infection. However, both time to onset of precancer/cancer and time to HPV clearance are interval-censored, and onset of precancer/cancer strongly informatively censors HPV clearance. We analyze this bivariate informatively interval-censored data by developing a novel joint model for time to clearance of HPV and time to precancer/cancer using shared random-effects, where the estimated mean duration of each woman’s HPV infection is a covariate in the submodel for time to precancer/cancer. The model was fit to data on 9,553 HPV-positive/Pap-negative women undergoing cervical cancer screening at Kaiser Permanente Northern California, data that were pivotal to the development of US screening guidelines. We compare the implications for screening intervals of this joint model to those from population-average marginal models of precancer/cancer risk. In particular, after 2 years the marginal population-average precancer/cancer risk was 5%, suggesting a 2-year interval to control population-average risk at 5%. In contrast, the joint model reveals that almost all women exceeding 5% individual risk in 2 years also exceeded 5% in 1 year, suggesting that a 1-year interval is better to control individual risk at 5%. The example suggests that sophisticated risk models capable of predicting individual risk may have different implications than population-average risk models that are currently used for informing medical guideline development. PMID:26556961

A joint model of persistent human papillomavirus infection and cervical cancer risk: Implications for cervical cancer screening.

PubMed

Katki, Hormuzd A; Cheung, Li C; Fetterman, Barbara; Castle, Philip E; Sundaram, Rajeshwari

2015-10-01

New cervical cancer screening guidelines in the US and many European countries recommend that women get tested for human papillomavirus (HPV). To inform decisions about screening intervals, we calculate the increase in precancer/cancer risk per year of continued HPV infection. However, both time to onset of precancer/cancer and time to HPV clearance are interval-censored, and onset of precancer/cancer strongly informatively censors HPV clearance. We analyze this bivariate informatively interval-censored data by developing a novel joint model for time to clearance of HPV and time to precancer/cancer using shared random-effects, where the estimated mean duration of each woman's HPV infection is a covariate in the submodel for time to precancer/cancer. The model was fit to data on 9,553 HPV-positive/Pap-negative women undergoing cervical cancer screening at Kaiser Permanente Northern California, data that were pivotal to the development of US screening guidelines. We compare the implications for screening intervals of this joint model to those from population-average marginal models of precancer/cancer risk. In particular, after 2 years the marginal population-average precancer/cancer risk was 5%, suggesting a 2-year interval to control population-average risk at 5%. In contrast, the joint model reveals that almost all women exceeding 5% individual risk in 2 years also exceeded 5% in 1 year, suggesting that a 1-year interval is better to control individual risk at 5%. The example suggests that sophisticated risk models capable of predicting individual risk may have different implications than population-average risk models that are currently used for informing medical guideline development.

Hunter-gatherer residential mobility and the marginal value of rainforest patches.

PubMed

Venkataraman, Vivek V; Kraft, Thomas S; Dominy, Nathaniel J; Endicott, Kirk M

2017-03-21

The residential mobility patterns of modern hunter-gatherers broadly reflect local resource availability, but the proximate ecological and social forces that determine the timing of camp movements are poorly known. We tested the hypothesis that the timing of such moves maximizes foraging efficiency as hunter-gatherers move across the landscape. The marginal value theorem predicts when a group should depart a camp and its associated foraging area and move to another based on declining marginal return rates. This influential model has yet to be directly applied in a population of hunter-gatherers, primarily because the shape of gain curves (cumulative resource acquisition through time) and travel times between patches have been difficult to estimate in ethnographic settings. We tested the predictions of the marginal value theorem in the context of hunter-gatherer residential mobility using historical foraging data from nomadic, socially egalitarian Batek hunter-gatherers ( n  = 93 d across 11 residential camps) living in the tropical rainforests of Peninsular Malaysia. We characterized the gain functions for all resources acquired by the Batek at daily timescales and examined how patterns of individual foraging related to the emergent property of residential movements. Patterns of camp residence times conformed well with the predictions of the marginal value theorem, indicating that communal perceptions of resource depletion are closely linked to collective movement decisions. Despite (and perhaps because of) a protracted process of deliberation and argument about when to depart camps, Batek residential mobility seems to maximize group-level foraging efficiency.

Hunter-gatherer residential mobility and the marginal value of rainforest patches

PubMed Central

Venkataraman, Vivek V.; Kraft, Thomas S.; Endicott, Kirk M.

2017-01-01

The residential mobility patterns of modern hunter-gatherers broadly reflect local resource availability, but the proximate ecological and social forces that determine the timing of camp movements are poorly known. We tested the hypothesis that the timing of such moves maximizes foraging efficiency as hunter-gatherers move across the landscape. The marginal value theorem predicts when a group should depart a camp and its associated foraging area and move to another based on declining marginal return rates. This influential model has yet to be directly applied in a population of hunter-gatherers, primarily because the shape of gain curves (cumulative resource acquisition through time) and travel times between patches have been difficult to estimate in ethnographic settings. We tested the predictions of the marginal value theorem in the context of hunter-gatherer residential mobility using historical foraging data from nomadic, socially egalitarian Batek hunter-gatherers (n = 93 d across 11 residential camps) living in the tropical rainforests of Peninsular Malaysia. We characterized the gain functions for all resources acquired by the Batek at daily timescales and examined how patterns of individual foraging related to the emergent property of residential movements. Patterns of camp residence times conformed well with the predictions of the marginal value theorem, indicating that communal perceptions of resource depletion are closely linked to collective movement decisions. Despite (and perhaps because of) a protracted process of deliberation and argument about when to depart camps, Batek residential mobility seems to maximize group-level foraging efficiency. PMID:28265058

Male Contraception: Research, New Methods, and Implications for Marginalized Populations.

PubMed

Plana, Olivia

2017-07-01

The majority of research on contraception has focused on manipulating the female reproductive system. Recent studies have identified novel contraceptives for males, including hormonal- and nonhormonal-based therapeutics. Although these new contraceptives are still undergoing clinical trials, their development and potential future use in society necessitate serious consideration of their implications for reproductive health. Through my analysis of the research conducted on male contraception over time and the current therapeutics available, it is clear that male contraception has the potential to shift societal gender dynamics and provide males with greater control over their own reproduction. This article also identifies the implications of these novel contraceptives for marginalized populations, especially men of color and men of lower socioeconomic positions. To overcome barriers to contraception among these populations, public policy efforts are needed in order to motivate the development of programs that facilitate coverage of these new male contraceptives by health plans and to increase their availability to underserved communities. Health care providers will be responsible for educating patients about these novel male contraception options and the need to continue using existing methods (e.g., condoms) in order to prevent sexually transmitted infections. This article analyzes the research conducted on male contraception and identifies the implications of these novel therapeutics for marginalized groups of men in the United States to identify the interventions that will be necessary to help ensure that all men have access to these promising scientific innovations.

Male Contraception: Research, New Methods, and Implications for Marginalized Populations

PubMed Central

Plana, Olivia

2015-01-01

The majority of research on contraception has focused on manipulating the female reproductive system. Recent studies have identified novel contraceptives for males, including hormonal- and nonhormonal-based therapeutics. Although these new contraceptives are still undergoing clinical trials, their development and potential future use in society necessitate serious consideration of their implications for reproductive health. Through my analysis of the research conducted on male contraception over time and the current therapeutics available, it is clear that male contraception has the potential to shift societal gender dynamics and provide males with greater control over their own reproduction. This article also identifies the implications of these novel contraceptives for marginalized populations, especially men of color and men of lower socioeconomic positions. To overcome barriers to contraception among these populations, public policy efforts are needed in order to motivate the development of programs that facilitate coverage of these new male contraceptives by health plans and to increase their availability to underserved communities. Health care providers will be responsible for educating patients about these novel male contraception options and the need to continue using existing methods (e.g., condoms) in order to prevent sexually transmitted infections. This article analyzes the research conducted on male contraception and identifies the implications of these novel therapeutics for marginalized groups of men in the United States to identify the interventions that will be necessary to help ensure that all men have access to these promising scientific innovations. PMID:26206159

Dune mobility and aridity at the desert margin of northern China at a time of peak monsoon strength

USGS Publications Warehouse

Mason, J.A.; Lu, H.; Zhou, Y.; Miao, X.; Swinehart, J.B.; Liu, Z.; Goble, R.J.; Yi, S.

2009-01-01

Wind-blown sands were mobile at many sites along the desert margin in northern China during the early Holocene (11.5-8 ka ago), based on extensive new numerical dating. This mobility implies low effective moisture at the desert margin, in contrast to growing evidence for greater than modern monsoon precipitation at the same time in central and southern China. Dry conditions in the early Holocene at the desert margin can be explained through a dynamic link between enhanced diabatic heating in the core region of the strengthened monsoon and increased subsidence in drylands to the north, combined with high evapotranspiration rates due to high summer temperatures. After 8 ka ago, as the monsoon weakened and lower temperatures reduced evapotranspiration, eolian sands were stabilized by vegetation. Aridity and dune mobility at the desert margin and a strengthened monsoon can both be explained as responses to high summer insolation in the early Holocene. ?? 2009 Geological Society of America.

Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment

PubMed Central

Kreek, Mary Jeanne

2013-01-01

Major well-defined medical problems that are, in part, the unfortunate outcome of a negative social environment may include specific addictive diseases and other mental health disorders, in particular the affective disorders of anxiety, depression, social phobia, and post-traumatic stress syndrome. This overview touches on the topic of extreme marginalization associated with addiction and other mental health disorders, along with arrest, imprisonment, and parole. All of these are characterized by lasting stigma that hauntingly continues to impact upon each person suffering from any of these problems. PMID:21884162

Geochemical evidence of mantle reservoir evolution during progressive rifting along the western Afar margin

NASA Astrophysics Data System (ADS)

Rooney, Tyrone O.; Mohr, Paul; Dosso, Laure; Hall, Chris

2013-02-01

The Afar triple junction, where the Red Sea, Gulf of Aden and African Rift System extension zones converge, is a pivotal domain for the study of continental-to-oceanic rift evolution. The western margin of Afar forms the southernmost sector of the western margin of the Red Sea rift where that margin enters the Ethiopian flood basalt province. Tectonism and volcanism at the triple junction had commenced by ˜31 Ma with crustal fissuring, diking and voluminous eruption of the Ethiopian-Yemen flood basalt pile. The dikes which fed the Oligocene-Quaternary lava sequence covering the western Afar rift margin provide an opportunity to probe the geochemical reservoirs associated with the evolution of a still active continental margin. 40Ar/39Ar geochronology reveals that the western Afar margin dikes span the entire history of rift evolution from the initial Oligocene flood basalt event to the development of focused zones of intrusion in rift marginal basins. Major element, trace element and isotopic (Sr-Nd-Pb-Hf) data demonstrate temporal geochemical heterogeneities resulting from variable contributions from the Afar plume, depleted asthenospheric mantle, and African lithosphere. The various dikes erupted between 31 Ma and 22 Ma all share isotopic signatures attesting to a contribution from the Afar plume, indicating this initial period in the evolution of the Afar margin was one of magma-assisted weakening of the lithosphere. From 22 Ma to 12 Ma, however, diffuse diking during continued evolution of the rift margin facilitated ascent of magmas in which depleted mantle and lithospheric sources predominated, though contributions from the Afar plume persisted. After 10 Ma, magmatic intrusion migrated eastwards towards the Afar rift floor, with an increasing fraction of the magmas derived from depleted mantle with less of a lithospheric signature. The dikes of the western Afar margin reveal that magma generation processes during the evolution of this continental rift margin are increasingly dominated by shallow decompressional melting of the ambient asthenosphere, the composition of which may in part be controlled by preferential channeling of plume material along the developing neo-oceanic axes of extension.

Rapid Prototyping of Continuous Fiber Reinforced Ceramic Matrix Composites

NASA Technical Reports Server (NTRS)

Vaidyanathan, R.; Green, C.; Phillips, T.; Cipriani, R.; Yarlagadda, S.; Gillespie, J.; Effinger, M.; Cooper, K. C.; Gordon, Gail (Technical Monitor)

2002-01-01

For ceramics to be used as structural components in high temperature applications, their fracture toughness is improved by embedding continuous ceramic fibers. Ceramic matrix composite (CMC) materials allow increasing the overall operating temperature, raising the temperature safety margins, avoiding the need for cooling, and improving the damping capacity, while reducing the weight at the same time. They also need to be reliable and available in large quantities as well. In this paper, an innovative rapid prototyping technique to fabricate continuous fiber reinforced ceramic matrix composites is described. The process is simple, robust and will be widely applicable to a number of high temperature material systems. This technique was originally developed at the University of Delaware Center for Composite Materials (UD-CCM) for rapid fabrication of polymer matrix composites by a technique called automated tow placement or ATP. The results of mechanical properties and microstructural characterization are presented, together with examples of complex shapes and parts. It is believed that the process will be able to create complex shaped parts at an order of magnitude lower cost than current CVI and PIP processes.

Spitzer observatory operations: increasing efficiency in mission operations

NASA Astrophysics Data System (ADS)

Scott, Charles P.; Kahr, Bolinda E.; Sarrel, Marc A.

2006-06-01

This paper explores the how's and why's of the Spitzer Mission Operations System's (MOS) success, efficiency, and affordability in comparison to other observatory-class missions. MOS exploits today's flight, ground, and operations capabilities, embraces automation, and balances both risk and cost. With operational efficiency as the primary goal, MOS maintains a strong control process by translating lessons learned into efficiency improvements, thereby enabling the MOS processes, teams, and procedures to rapidly evolve from concept (through thorough validation) into in-flight implementation. Operational teaming, planning, and execution are designed to enable re-use. Mission changes, unforeseen events, and continuous improvement have often times forced us to learn to fly anew. Collaborative spacecraft operations and remote science and instrument teams have become well integrated, and worked together to improve and optimize each human, machine, and software-system element. Adaptation to tighter spacecraft margins has facilitated continuous operational improvements via automated and autonomous software coupled with improved human analysis. Based upon what we now know and what we need to improve, adapt, or fix, the projected mission lifetime continues to grow - as does the opportunity for numerous scientific discoveries.

Elevated Passive Continental Margins may form much Later than the time of Rifting

NASA Astrophysics Data System (ADS)

Chalmers, J. A.; Japsen, P.; Green, P. F.; Bonow, J.; Lidmar-Bergstrom, K.

2007-12-01

Many current models of the development of elevated passive continental margins assume that they are either the remains of foot-wall uplift at the time of rifting or due to underplating by magma from a plume or other mantle source. We have studied the rift and post-rift history of such a passive margin in West and South Greenland and have concluded that the present-day elevations developed 25-60 million years after cessation of rifting and local volcanism, suggesting that additional factors need to be considered when modelling such margins. The morphology of West Greenland is similar to that of other elevated passive margins ion many parts of the world. There are high-level, large-scale, quasi-planar landscapes (planation surfaces) at altitudes of 1-2 km cut by deeply incised valleys. The gradient from the highest ground to the coast is much steeper than that away from the coast. We combined analysis of the morphology of the landscape with studies of fission tracks and the preserved stratigraphic record both on- and off-shore. Rifting and the commencement of sea-floor spreading in the Early Paleogene was accompanied by voluminous high-temperature volcanism. Kilometer-scale uplift at the time of rifting was followed shortly afterwards by kilometer-scale subsidence and possibly by transgression of marine sediments across the rift margin. The present elevated margin formed during three episodes of uplift during the Neogene, 25-60 million years after the cessation of rifting and local volcanism. The quasi-planar planation surfaces presently at 1-2 km altitude are the end-products of denudation to near sea-level in the mid- and late Cenozoic and these surfaces were uplifted to their present altitudes during the Neogene events. Rivers then incised the summit surface to form valleys that were further enlarged and deepened by glaciers. Similar elevated margins exist all around the northern North Atlantic and in many other parts of the world; eastern North America, on both sides of the South Atlantic, western India, eastern Australia, and possibly in Antarctica. Our results show that we cannot simply assume that these elevations were produced either at the time of rifting or as underplating at the time of plume impact. There is, however, no general agreement as to what caused them and we suggest that the history of these margins need to be re-assessed in the light of our results.

Elevated Passive Continental Margins may form much Later than the time of Rifting

NASA Astrophysics Data System (ADS)

Chalmers, J. A.; Japsen, P.; Green, P. F.; Bonow, J.; Lidmar-Bergstrom, K.

2004-12-01

Many current models of the development of elevated passive continental margins assume that they are either the remains of foot-wall uplift at the time of rifting or due to underplating by magma from a plume or other mantle source. We have studied the rift and post-rift history of such a passive margin in West and South Greenland and have concluded that the present-day elevations developed 25-60 million years after cessation of rifting and local volcanism, suggesting that additional factors need to be considered when modelling such margins. The morphology of West Greenland is similar to that of other elevated passive margins ion many parts of the world. There are high-level, large-scale, quasi-planar landscapes (planation surfaces) at altitudes of 1-2 km cut by deeply incised valleys. The gradient from the highest ground to the coast is much steeper than that away from the coast. We combined analysis of the morphology of the landscape with studies of fission tracks and the preserved stratigraphic record both on- and off-shore. Rifting and the commencement of sea-floor spreading in the Early Paleogene was accompanied by voluminous high-temperature volcanism. Kilometer-scale uplift at the time of rifting was followed shortly afterwards by kilometer-scale subsidence and possibly by transgression of marine sediments across the rift margin. The present elevated margin formed during three episodes of uplift during the Neogene, 25-60 million years after the cessation of rifting and local volcanism. The quasi-planar planation surfaces presently at 1-2 km altitude are the end-products of denudation to near sea-level in the mid- and late Cenozoic and these surfaces were uplifted to their present altitudes during the Neogene events. Rivers then incised the summit surface to form valleys that were further enlarged and deepened by glaciers. Similar elevated margins exist all around the northern North Atlantic and in many other parts of the world; eastern North America, on both sides of the South Atlantic, western India, eastern Australia, and possibly in Antarctica. Our results show that we cannot simply assume that these elevations were produced either at the time of rifting or as underplating at the time of plume impact. There is, however, no general agreement as to what caused them and we suggest that the history of these margins need to be re-assessed in the light of our results.

Effect of tightening torque on the marginal adaptation of cement-retained implant-supported fixed dental prostheses

PubMed Central

Ghanbarzadeh, Jalil; Dashti, Hossin; Karamad, Reza; Alikhasi, Marzieh; Nakhaei, Mohammadreza

2015-01-01

Background: The final position of the abutment changes with the amount of tightening torque. This could eventually lead to loss of passivity and marginal misfit of prostheses. The aim of this study was to evaluate the effect of three different tightening torques on the marginal adaptation of 3-unit cement-retained implant-supported fixed dental prostheses (FDPs). Materials and Methods: Two implants (Straumann) were inserted in an acrylic block so that one of the implants was placed vertically and the other at a 15° vertical angle. A straight abutment and a 15° angulated abutment were connected to the vertically and obliquely installed implants, respectively, so that the two abutments were parallel. Then, 10 cement-retained FDPs were waxed and cast. Abutments were tightened with 10, 20, and 35 Ncm torques, respectively. Following each tightening torque, FDPs were luted on respective abutments with temporary cement. The marginal adaptation of the retainers was evaluated using stereomicroscope. FDPs were then removed from the abutments and were sectioned at the connector sites. The retainers were luted again on their respective abutments. Luting procedures and marginal adaptation measurement were repeated. Data were analyzed by ANOVA and least significant difference tests (α = 0.05). After cutting the FDP connectors, the independent samples t-test was used to compare misfit values (α = 0.05). Results: Following 10, 20, and 35 Ncm tightening torques, the marginal discrepancy of the retainers of FDPs significantly increased (P < 0.05). There was no significant difference between the marginal discrepancies of these two retainers (P > 0.05). The marginal gap values of angulated abutment retainers (ANRs) were significantly higher than those of the straight abutment after cutting the connectors (P = 0.026). Conclusion: Within the limitations of this study, the marginal misfit of cement-retained FDPs increased continuously when the tightening torque increased. After cutting the connectors, the marginal misfit of the ANRs was higher than those of the straight abutment retainers. PMID:26288627

Effect of tightening torque on the marginal adaptation of cement-retained implant-supported fixed dental prostheses.

PubMed

Ghanbarzadeh, Jalil; Dashti, Hossin; Karamad, Reza; Alikhasi, Marzieh; Nakhaei, Mohammadreza

2015-01-01

The final position of the abutment changes with the amount of tightening torque. This could eventually lead to loss of passivity and marginal misfit of prostheses. The aim of this study was to evaluate the effect of three different tightening torques on the marginal adaptation of 3-unit cement-retained implant-supported fixed dental prostheses (FDPs). Two implants (Straumann) were inserted in an acrylic block so that one of the implants was placed vertically and the other at a 15° vertical angle. A straight abutment and a 15° angulated abutment were connected to the vertically and obliquely installed implants, respectively, so that the two abutments were parallel. Then, 10 cement-retained FDPs were waxed and cast. Abutments were tightened with 10, 20, and 35 Ncm torques, respectively. Following each tightening torque, FDPs were luted on respective abutments with temporary cement. The marginal adaptation of the retainers was evaluated using stereomicroscope. FDPs were then removed from the abutments and were sectioned at the connector sites. The retainers were luted again on their respective abutments. Luting procedures and marginal adaptation measurement were repeated. Data were analyzed by ANOVA and least significant difference tests (α = 0.05). After cutting the FDP connectors, the independent samples t-test was used to compare misfit values (α = 0.05). Following 10, 20, and 35 Ncm tightening torques, the marginal discrepancy of the retainers of FDPs significantly increased (P < 0.05). There was no significant difference between the marginal discrepancies of these two retainers (P > 0.05). The marginal gap values of angulated abutment retainers (ANRs) were significantly higher than those of the straight abutment after cutting the connectors (P = 0.026). Within the limitations of this study, the marginal misfit of cement-retained FDPs increased continuously when the tightening torque increased. After cutting the connectors, the marginal misfit of the ANRs was higher than those of the straight abutment retainers.

Knowledge Work, Working Time, and Use of Time among Finnish Dual-Earner Families: Does Knowledge Work Require the Marginalization of Private Life?

ERIC Educational Resources Information Center

Natti, Jouko; Anttila, Timo; Tammelin, Mia

2012-01-01

The industrial working-time regime is dissolving--not dramatically, but rather as a trend. A new trend is that those in dynamic sectors and in a good labor market position work long hours: Demanding knowledge work appears to require the marginalization of private life. This study investigates the family situation of knowledge workers, the…

Opened Proton Pump Inhibitor Capsules Reduce Time to Healing Compared With Intact Capsules for Marginal Ulceration Following Roux-en-Y Gastric Bypass.

PubMed

Schulman, Allison R; Chan, Walter W; Devery, Aiofe; Ryan, Michele B; Thompson, Christopher C

2017-04-01

Marginal ulceration, or ulceration at the gastrojejunal anastomosis, is a common complication of Roux-en-Y gastric bypass (RYGB). Acidity likely contributes to the pathophysiology, and proton pump inhibitors (PPIs) frequently are prescribed for treatment. However, patients with gastric bypass only have a small gastric pouch and rapid small-bowel transit, which limits the opportunity for capsule breakdown and PPI absorption. Soluble PPIs (open capsules [OCs]) might be absorbed more easily than intact capsules (ICs). We compared time to ulcer healing, number of endoscopic procedures, and use of health care for patients with marginal ulceration who received PPIs in OC vs IC form. We performed a retrospective study of 164 patients diagnosed with marginal ulceration who underwent RYGB at the Brigham and Women's Hospital from 2000 through 2015. Patients received high-dose PPIs and underwent repeat endoscopy every 3 months until ulcer healing was confirmed. We used time-to-event analysis with a Cox proportional hazards model to evaluate the association between mode of PPI administration and time to ulcer healing, in addition to Cox multivariate regression analysis. Total charge (procedural and maintenance) was determined by comparison of categorized charges incurred from time of ulcer diagnosis to resolution. The primary outcome was time to healing of marginal ulceration in RYGB patients receiving high-dose PPIs in OC vs IC form. A total of 162 patients were included (115 received OC and 49 received IC). All patients were followed up until ulcer healing was confirmed. The median time to ulcer healing was 91.0 days for the OC group vs 342.0 days for the IC group (P < .001). OC was the only independent predictor of time to ulcer healing (P < .001) when we controlled for known risk factors. The number of endoscopic procedures (P = .02) and overall health care utilization (P = .05) were lower in the OC than the IC group. Patients with marginal ulceration after RYGB who receive OC PPIs have shorter ulcer healing times, fewer endoscopic procedures, and use less health care resources compared with patients who receive IC PPIs. Given these results and the high prevalence of marginal ulceration in this patient population, the use of OC PPIs is a low-risk, low-cost alternative that should be considered. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Marginally outer trapped surfaces and symmetries

NASA Astrophysics Data System (ADS)

Carrasco, Alberto; Mars, Marc

2009-05-01

We study properties of outermost marginally outer trapped surfaces in slices of space-times possessing certain symmetries, like isometries, homotheties or conformal Killings. In particular, we find restrictions on these surfaces for the vector field generating the symmetry. As an application we give a result of non-existence of outermost marginally outer trapped surfaces in accelerated Friedmann-Lemaître-Roberson-Walker spacetimes.

Stability Metrics for Simulation and Flight-Software Assessment and Monitoring of Adaptive Control Assist Compensators

NASA Technical Reports Server (NTRS)

Hodel, A. S.; Whorton, Mark; Zhu, J. Jim

2008-01-01

Due to a need for improved reliability and performance in aerospace systems, there is increased interest in the use of adaptive control or other nonlinear, time-varying control designs in aerospace vehicles. While such techniques are built on Lyapunov stability theory, they lack an accompanying set of metrics for the assessment of stability margins such as the classical gain and phase margins used in linear time-invariant systems. Such metrics must both be physically meaningful and permit the user to draw conclusions in a straightforward fashion. We present in this paper a roadmap to the development of metrics appropriate to nonlinear, time-varying systems. We also present two case studies in which frozen-time gain and phase margins incorrectly predict stability or instability. We then present a multi-resolution analysis approach that permits on-line real-time stability assessment of nonlinear systems.

Time Domain Stability Margin Assessment of the NASA Space Launch System GN&C Design for Exploration Mission One

NASA Technical Reports Server (NTRS)

Clements, Keith; Wall, John

2017-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

Time Domain Stability Margin Assessment of the NS Space Launch System GN&C Design for Exploration Mission One

NASA Technical Reports Server (NTRS)

Clements, Keith; Wall, John

2017-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

Detection of brain tumor margins using optical coherence tomography

NASA Astrophysics Data System (ADS)

Juarez-Chambi, Ronald M.; Kut, Carmen; Rico-Jimenez, Jesus; Campos-Delgado, Daniel U.; Quinones-Hinojosa, Alfredo; Li, Xingde; Jo, Javier

2018-02-01

In brain cancer surgery, it is critical to achieve extensive resection without compromising adjacent healthy, noncancerous regions. Various technological advances have made major contributions in imaging, including intraoperative magnetic imaging (MRI) and computed tomography (CT). However, these technologies have pros and cons in providing quantitative, real-time and three-dimensional (3D) continuous guidance in brain cancer detection. Optical Coherence Tomography (OCT) is a non-invasive, label-free, cost-effective technique capable of imaging tissue in three dimensions and real time. The purpose of this study is to reliably and efficiently discriminate between non-cancer and cancerinfiltrated brain regions using OCT images. To this end, a mathematical model for quantitative evaluation known as the Blind End-Member and Abundances Extraction method (BEAE). This BEAE method is a constrained optimization technique which extracts spatial information from volumetric OCT images. Using this novel method, we are able to discriminate between cancerous and non-cancerous tissues and using logistic regression as a classifier for automatic brain tumor margin detection. Using this technique, we are able to achieve excellent performance using an extensive cross-validation of the training dataset (sensitivity 92.91% and specificity 98.15%) and again using an independent, blinded validation dataset (sensitivity 92.91% and specificity 86.36%). In summary, BEAE is well-suited to differentiate brain tissue which could support the guiding surgery process for tissue resection.

Detection of brain tumor margins using optical coherence tomography

NASA Astrophysics Data System (ADS)

Juarez-Chambi, Ronald M.; Kut, Carmen; Rico-Jimenez, Jesus; Campos-Delgado, Daniel U.; Quinones-Hinojosa, Alfredo; Li, Xingde; Jo, Javier

2018-02-01

In brain cancer surgery, it is critical to achieve extensive resection without compromising adjacent healthy, non-cancerous regions. Various technological advances have made major contributions in imaging, including intraoperative magnetic imaging (MRI) and computed tomography (CT). However, these technologies have pros and cons in providing quantitative, real-time and three-dimensional (3D) continuous guidance in brain cancer detection. Optical Coherence Tomography (OCT) is a non-invasive, label-free, cost-effective technique capable of imaging tissue in three dimensions and real time. The purpose of this study is to reliably and efficiently discriminate between non-cancer and cancer-infiltrated brain regions using OCT images. To this end, a mathematical model for quantitative evaluation known as the Blind End- Member and Abundances Extraction method (BEAE). This BEAE method is a constrained optimization technique which extracts spatial information from volumetric OCT images. Using this novel method, we are able to discriminate between cancerous and non-cancerous tissues and using logistic regression as a classifier for automatic brain tumor margin detection. Using this technique, we are able to achieve excellent performance using an extensive cross-validation of the training dataset (sensitivity 92.91% and specificity 98.15%) and again using an independent, blinded validation dataset (sensitivity 92.91% and specificity 86.36%). In summary, BEAE is well-suited to differentiate brain tissue which could support the guiding surgery process for tissue resection.

Is plant temporal beta diversity of field margins related to changes in management practices?

NASA Astrophysics Data System (ADS)

Alignier, Audrey; Baudry, Jacques

2016-08-01

Field margins have considerable ecological significance in agriculture-dominated landscapes by supporting biodiversity and associated services. However, agricultural changes during mid-20th century led to their drastic loss with a serious threat for biodiversity. Using time-series data, we aimed to get better insights into processes underlying plant patterns of field margins through time by i) quantifying plant temporal beta diversity components, ii) assessing whether the observed changes in plant communities can be related to changes in management practices applied to field margins. During the springs of 1994, 1998 and 2001, we surveyed plant communities and management practices of the same 116 field margins in three contrasted landscapes. We estimated temporal beta diversity in plant communities and partitioned it into its two dissimilarity resultant components, accounting for replacement of species (i.e. turnover) and for the nested gain or loss of species (i.e. nestedness). We then tested whether the observed changes in plant communities between 1994 and 1998 and, between 1998 and 2001 were related to changes in management practices using linear models. Plant communities of field margins exhibited strong temporal beta diversity dominated by turnover. Temporal turnover in plant communities was partly related to changes in management practices, i.e., a decrease of grazing concomitant to an increase of herbicide spraying. However, relationships were not consistent between all landscape contexts nor time period, suggesting that other unmeasured deterministic or stochastic processes could be driving the observed plant patterns. Taken together, our results suggest that maintaining a wide diversity of field margins with contrasted management contribute to maintaining plant diversity at a landscape scale. They underline the value of investigating plant temporal diversity patterns using time-series data and thus, the need to develop long-term studies making it possible to understand ecological processes shaping plant communities in agricultural landscapes.

Criticality and Chaos in Systems of Communities

NASA Astrophysics Data System (ADS)

Ostilli, Massimo; Figueiredo, Wagner

2016-01-01

We consider a simple model of communities interacting via bilinear terms. After analyzing the thermal equilibrium case, which can be described by an Hamiltonian, we introduce the dynamics that, for Ising-like variables, reduces to a Glauber-like dynamics. We analyze and compare four different versions of the dynamics: flow (differential equations), map (discretetime dynamics), local-time update flow, and local-time update map. The presence of only bilinear interactions prevent the flow cases to develop any dynamical instability, the system converging always to the thermal equilibrium. The situation is different for the map when unfriendly couplings are involved, where period-two oscillations arise. In the case of the map with local-time updates, oscillations of any period and chaos can arise as a consequence of the reciprocal “tension” accumulated among the communities during their sleeping time interval. The resulting chaos can be of two kinds: true chaos characterized by positive Lyapunov exponent and bifurcation cascades, or marginal chaos characterized by zero Lyapunov exponent and critical continuous regions.

Robust inference in discrete hazard models for randomized clinical trials.

PubMed

Nguyen, Vinh Q; Gillen, Daniel L

2012-10-01

Time-to-event data in which failures are only assessed at discrete time points are common in many clinical trials. Examples include oncology studies where events are observed through periodic screenings such as radiographic scans. When the survival endpoint is acknowledged to be discrete, common methods for the analysis of observed failure times include the discrete hazard models (e.g., the discrete-time proportional hazards and the continuation ratio model) and the proportional odds model. In this manuscript, we consider estimation of a marginal treatment effect in discrete hazard models where the constant treatment effect assumption is violated. We demonstrate that the estimator resulting from these discrete hazard models is consistent for a parameter that depends on the underlying censoring distribution. An estimator that removes the dependence on the censoring mechanism is proposed and its asymptotic distribution is derived. Basing inference on the proposed estimator allows for statistical inference that is scientifically meaningful and reproducible. Simulation is used to assess the performance of the presented methodology in finite samples.

The Subject of Data in Submissions to the CLCS: Documenting the outer limits of the Northern Continental Shelf of the Faroe Islands

NASA Astrophysics Data System (ADS)

Vang Heinesen, Martin; Mørk, Finn

2017-04-01

The first partial submissions made by the Kingdom of Denmark, in respect of the continental shelf north of the Faroe Islands (North Faroe Margin, NFM), was submitted to the Commission on the Limits of the Continental Shelf in April 2009 as the result of 7 years of preparation which also included 4 additional continental shelf regions around the Faroe Islands and Greenland, on which individual partial submissions were made subsequently. The NFM covers parts of the NW European continental margin, it continues onto the Faroe-Iceland Ridge and the extinct Ægir (spreading) Ridge and overlaps with the continental margin of Iceland and Norway in the sediment rich Ægir Basin located between the European margin to the south and south-east, and the Jan Mayen Micro-continental margin to the west and north-west. Prior to the onset of the continental shelf project of the Kingdom of Denmark, arrangements had already been made with Norway and Iceland regarding the sharing of existing data and acquisition of new seismic data in the overlapping regions. Before that, the main database in the area included a comprehensive multi-beam bathymetric data set covering large parts of the Ægir Ridge with scattered single beam bathymetric lines in the remaining regions. It also comprised a number of single- and multi-channel seismic lines and a long refraction seismic line transecting the entire eastern part of the basin, from the Norwegian shelf to the Ægir Ridge, in addition to local side scan sonar and regional potential field data. During the project, additional high quality multi-channel seismic data, extensive multi-beam bathymetric data, and a comprehensive high resolution aeromagnetic dataset were acquired, allowing detailed mapping of the morphological and geological nature of the margin, including accurate identification of the base of the continental slope and mapping of the sediment thickness and sediment continuation in the basin. This data proved to be crucial for the documentation to the CLCS of the outer limits of the continental shelf to the north of the Faroe Islands.

A comparison of marginal fit between press-fabricated and CAD/CAM lithium disilicate crowns.

PubMed

Carlile, Richard S; Owens, Wade H; Greenwood, William J; Guevara, Peter H

2018-01-01

The purpose of this study was to compare the marginal fit of press-fabricated lithium disilicate crowns with that of computer-aided design/computer-aided manufacturing (CAD/CAM) lithium disilicate crowns to determine if the fabrication method has an influence on marginal fit. The marginal fit of 25 pressed and 25 CAD/CAM crowns was measured using the replica technique. The sites measured were the mesial, distal, facial, and lingual margins. A microscope at 10× magnification was used to obtain the measurements. Each site was measured 4 times, and intraclass correlation coefficients were used to assess measurement errors. An unpaired t test was used to evaluate the differences between the 2 groups. Mean marginal gap measurements were greater for CAD/CAM crowns than for pressed crowns at all sites. Only the difference in mean gap at the facial margin was statistically significant (P < 0.001). Press-fabricated lithium disilicate crowns provided a better marginal fit than those fabricated by CAD/CAM, but both fabrication methods provided crowns with a clinically acceptable marginal fit.

Continental margin sedimentation: From sediment transport to sequence stratigraphy

USGS Publications Warehouse

Nittrouer, Charles A.; Austin, James A.; Field, Michael E.; Kravitz, Joseph H.; Syvitski, James P. M.; Wiberg, Patricia L.

2007-01-01

This volume on continental margin sedimentation brings together an expert editorial and contributor team to create a state-of-the-art resource. Taking a global perspective, the book spans a range of timescales and content, ranging from how oceans transport particles, to how thick rock sequences are formed on continental margins.- Summarizes and integrates our understanding of sedimentary processes and strata associated with fluvial dispersal systems on continental shelves and slopes- Explores timescales ranging from particle transport at one extreme, to deep burial at the other- Insights are presented for margins in general, and with focus on a tectonically active margin (northern California) and a passive margin (New Jersey), enabling detailed examination of the intricate relationships between a wide suite of sedimentary processes and their preserved stratigraphy- Includes observational studies which document the processes and strata found on particular margins, in addition to numerical models and laboratory experimentation, which provide a quantitative basis for extrapolation in time and space of insights about continental-margin sedimentation- Provides a research resource for scientists studying modern and ancient margins, and an educational text for advanced students in sedimentology and stratigraphy

Excess Capacity in China’s Power Systems: A Regional Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Jiang; Liu, Xu; Karl, Fredrich

2016-11-01

This paper examines China’s regional electricity grids using a reliability perspective, which is commonly measured in terms of a reserve margin. Our analysis shows that at the end of 2014, the average reserve margin for China as a whole was roughly 28%, almost twice as high as a typical planning reserve margin in the U.S. However, this national average masks huge variations in reserve margins across major regional power grid areas: the northeastern region has the highest reserve margin of over 60%, followed by the northwestern region at 49%, and the southern grid area at 35%. In this analysis, wemore » also examined future reserve margins for regional electricity grids in China under two scenarios: 1) a low scenario of national annual electricity consumption growth rates of 1.5% between 2015 and 2020 and 1.0% between 2020 and 2025, and 2) a high scenario of annual average growth rates of 3.0% and 2.0%, respectively. Both scenarios suggest that the northeastern, northwestern, and southern regions have significant excess generation capacity, and that this excess capacity situation will continue over the next decade without regulatory intervention. The northern and central regions could have sufficient generation capacity to 2020, but may require additional resources in a higher growth scenario. The eastern region requires new resources by 2020 in both scenarios.« less

The limits of seaward spreading and slope instability at the continental margin offshore Mt Etna, imaged by high-resolution 2D seismic data

NASA Astrophysics Data System (ADS)

Gross, Felix; Krastel, Sebastian; Geersen, Jacob; Behrmann, Jan Hinrich; Ridente, Domenico; Chiocci, Francesco Latino; Bialas, Jörg; Papenberg, Cord; Cukur, Deniz; Urlaub, Morelia; Micallef, Aaron

2016-01-01

Mount Etna is the largest active volcano in Europe. Instability of its eastern flank is well documented onshore, and continuously monitored by geodetic and InSAR measurements. Little is known, however, about the offshore extension of the eastern volcano flank, defining a serious shortcoming in stability models. In order to better constrain the active tectonics of the continental margin offshore the eastern flank of the volcano, we acquired a new high-resolution 2D reflection seismic dataset. The data provide new insights into the heterogeneous geology and tectonics at the continental margin offshore Mt Etna. The submarine realm is characterized by different blocks, which are controlled by local- and regional tectonics. A compressional regime is found at the toe of the continental margin, which is bound to a complex basin system. Both, the clear link between on- and offshore tectonic structures as well as the compressional regime at the easternmost flank edge, indicate a continental margin gravitational collapse as well as spreading to be present at Mt Etna. Moreover, we find evidence for the offshore southern boundary of the moving flank, which is identified as a right lateral oblique fault north of Catania Canyon. Our findings suggest a coupled volcano edifice/continental margin instability at Mt Etna, demonstrating first order linkage between on- and offshore tectonic processes.

Geohistory analysis of the Santa Maria basin, California, and its relationship to tectonic evolution of the continental margin

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCrory, P.A.; Arends, R.G.; Ingle, J.C. Jr.

1991-02-01

The Santa Maria basin of central California is a geologically complex area located along the tectonically active California continental margin. The record of Cenozoic tectonism preserved in Santa Maria strata provides an opportunity to compare the evolution of the region with plate tectonic models for Cenozoic interactions along the margin. Geohistory analysis of Neogene Santa Maria basin strata provides important constraints for hypotheses of the tectonic evolution of the central California margin during its transition from a convergent to a transform plate boundary. Preliminary analyses suggest that the tectonic evolution of the Santa Maria area was dominated by coupling betweenmore » adjacent oceanic plates and the continental margin. This coupling is reflected in the timing of major hiatuses within the basin sedimentary sequence and margin subsidence and uplift which occurred during periods of tectonic plate adjustment. Stratigraphic evidence indicates that the Santa Maria basin originated on the continental shelf in early Miocene time. A component of margin subsidence is postulated to have been caused by cessation of spreading on adjacent offshore microplates approximately 19-18 ma. A sharp reduction in rate of tectonic subsidence in middle Miocene time, observed in the Santa Maria basin both onshore and offshore, was coeval with rotation of crustal blocks as major shearing shifts shoreward. Tectonic uplift of two eastern sites, offshore Point Arguello and near Point Sal, in the late Miocene may have been related to a change to transpressional motion between the Pacific and North American plates, as well as to rotation of the western Transverse Ranges in a restraining geometry.« less

Influence of surgical and prosthetic techniques on marginal bone loss around titanium implants. Part I: immediate loading in fresh extraction sockets.

PubMed

Berberi, Antoine N; Tehini, Georges E; Noujeim, Ziad F; Khairallah, Alexandre A; Abousehlib, Moustafa N; Salameh, Ziad A

2014-10-01

Delayed placement of implant abutments has been associated with peri-implant marginal bone loss; however, long-term results obtained by modifying surgical and prosthetic techniques after implant placement are still lacking. This study aimed to evaluate the marginal bone loss around titanium implants placed in fresh extraction sockets using two loading protocols after a 5-year follow-up period. A total of 36 patients received 40 titanium implants (Astra Tech) intended for single-tooth replacement. Implants were immediately placed into fresh extraction sockets using either a one-stage (immediate loading by placing an interim prosthesis into functional occlusion) or a two-stage prosthetic loading protocol (insertion of abutments after 8 weeks of healing time). Marginal bone levels relative to the implant reference point were evaluated at four time intervals using intraoral radiographs: at time of implant placement, and 1, 3, and 5 years after implant placement. Measurements were obtained from mesial and distal surfaces of each implant (α = 0.05). One-stage immediate implant placement into fresh extraction sockets resulted in a significant reduction in marginal bone loss (p < 0.002) compared to the traditional two-stage technique. Whereas mesial surfaces remained stable for the 5-year observation period, significant marginal bone loss was observed on distal surfaces of implants after cementation of interim prostheses (p < 0.007) and after 12 months (p < 0.034). Within the limitations of this study, immediate loading of implants placed into fresh extraction sockets reduced marginal bone loss and did not compromise the success rate of the restorations. © 2014 by the American College of Prosthodontists.

Comparative biogeochemistry-ecosystem-human interactions on dynamic continental margins

USGS Publications Warehouse

Levin, Lisa A.; Liu, Kon-Kee; Emeis, Kay-Christian; Breitburg, Denise L.; Cloern, James; Deutsch, Curtis; Giani, Michele; Goffart, Anne; Hofmann, Eileen E.; Lachkar, Zouhair; Limburg, Karin; Liu, Su-Mei; Montes, Enrique; Naqvi, Wajih; Ragueneau, Olivier; Rabouille, Christophe; Sarkar, Santosh Kumar; Swaney, Dennis P.; Wassman, Paul; Wishner, Karen F.

2014-01-01

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins.

Comparative biogeochemistry-ecosystem-human interactions on dynamic continental margins

NASA Astrophysics Data System (ADS)

Levin, Lisa A.; Liu, Kon-Kee; Emeis, Kay-Christian; Breitburg, Denise L.; Cloern, James; Deutsch, Curtis; Giani, Michele; Goffart, Anne; Hofmann, Eileen E.; Lachkar, Zouhair; Limburg, Karin; Liu, Su-Mei; Montes, Enrique; Naqvi, Wajih; Ragueneau, Olivier; Rabouille, Christophe; Sarkar, Santosh Kumar; Swaney, Dennis P.; Wassman, Paul; Wishner, Karen F.

2015-01-01

The oceans' continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins, (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services. These include primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins.

Reconciling records of ice streaming and ice margin retreat to produce a palaeogeographic reconstruction of the deglaciation of the Laurentide Ice Sheet

NASA Astrophysics Data System (ADS)

Margold, Martin; Stokes, Chris R.; Clark, Chris D.

2018-06-01

This paper reconstructs the deglaciation of the Laurentide Ice Sheet (LIS; including the Innuitian Ice Sheet) from the Last Glacial Maximum (LGM), with a particular focus on the spatial and temporal variations in ice streaming and the associated changes in flow patterns and ice divides. We build on a recent inventory of Laurentide ice streams and use an existing ice margin chronology to produce the first detailed transient reconstruction of the ice stream drainage network in the LIS, which we depict in a series of palaeogeographic maps. Results show that the drainage network at the LGM was similar to modern-day Antarctica. The majority of the ice streams were marine terminating and topographically-controlled and many of these continued to function late into the deglaciation, until the ice sheet lost its marine margin. Ice streams with a terrestrial ice margin in the west and south were more transient and ice flow directions changed with the build-up, peak-phase and collapse of the Cordilleran-Laurentide ice saddle. The south-eastern marine margin in Atlantic Canada started to retreat relatively early and some of the ice streams in this region switched off at or shortly after the LGM. In contrast, the ice streams draining towards the north-western and north-eastern marine margins in the Beaufort Sea and in Baffin Bay appear to have remained stable throughout most of the Late Glacial, and some of them continued to function until after the Younger Dryas (YD). The YD influenced the dynamics of the deglaciation, but there remains uncertainty about the response of the ice sheet in several sectors. We tentatively ascribe the switching-on of some major ice streams during this period (e.g. M'Clintock Channel Ice Stream at the north-west margin), but for other large ice streams whose timing partially overlaps with the YD, the drivers are less clear and ice-dynamical processes, rather than effects of climate and surface mass balance are viewed as more likely drivers. Retreat rates markedly increased after the YD and the ice sheet became limited to the Canadian Shield. This hard-bed substrate brought a change in the character of ice streaming, which became less frequent but generated much broader terrestrial ice streams. The final collapse of the ice sheet saw a series of small ephemeral ice streams that resulted from the rapidly changing ice sheet geometry in and around Hudson Bay. Our reconstruction indicates that the LIS underwent a transition from a topographically-controlled ice drainage network at the LGM to an ice drainage network characterised by less frequent, broad ice streams during the later stages of deglaciation. These deglacial ice streams are mostly interpreted as a reaction to localised ice-dynamical forcing (flotation and calving of the ice front in glacial lakes and transgressing sea; basal de-coupling due to large amount of meltwater reaching the bed, debuttressing due to rapid changes in ice sheet geometry) rather than as conveyors of excess mass from the accumulation area of the ice sheet. At an ice sheet scale, the ice stream drainage network became less widespread and less efficient with the decreasing size of the deglaciating ice sheet, the final elimination of which was mostly driven by surface melt.

Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography

PubMed Central

Nguyen, Freddy T.; Zysk, Adam M.; Chaney, Eric J.; Kotynek, Jan G.; Oliphant, Uretz J.; Bellafiore, Frank J.; Rowland, Kendrith M.; Johnson, Patricia A.; Boppart, Stephen A.

2009-01-01

As breast cancer screening rates increase, smaller and more numerous lesions are being identified earlier, leading to more breast-conserving surgical procedures. Achieving a clean surgical margin represents a technical challenge with important clinical implications. Optical coherence tomography (OCT) is introduced as an intraoperative high-resolution imaging technique that assesses surgical breast tumor margins by providing real-time microscopic images up to 2 mm beneath the tissue surface. In a study of 37 patients split between training and study groups, OCT images covering 1 cm2 regions were acquired from surgical margins of lumpectomy specimens, registered with ink, and correlated with corresponding histological sections. A 17 patient training set used to establish standard imaging protocols and OCT evaluation criteria demonstrated that areas of higher scattering tissue with a heterogeneous pattern were indicative of tumor cells and tumor tissue, in contrast to lower scattering adipocytes found in normal breast tissue. The remaining 20 patients were enrolled into the feasibility study. Of these lumpectomy specimens, 11 were identified with a positive or close surgical margin and 9 were identified with a negative margin under OCT. Based on histological findings, 9 true positives, 9 true negatives, 2 false positives, and 0 false negatives were found, yielding a sensitivity of 100% and specificity of 82%. These results demonstrate the potential of OCT as a real-time method for intraoperative margin assessment in breast conserving surgeries. PMID:19910294

Prevalence and predictive factors for the detection of carcinoma in cavity margin performed at the time of breast lumpectomy.

PubMed

Tengher-Barna, Iulia; Hequet, Delphine; Reboul-Marty, Jeanne; Frassati-Biaggi, Annonciade; Seince, Nathalie; Rodrigues-Faure, Anabela; Uzan, Michèle; Ziol, Marianne

2009-02-01

Margin resection status is a major risk factor for the development of local recurrence in breast conservation therapy for carcinoma. Tumor bed excision sent as separate orientated cavity margins represents a tool to verify the completeness of the carcinoma resection. We aimed to (1) determine the prevalence of positive cavity margin and its influence on subsequent surgical treatment and (2) identify potential predictive factors for positive cavity margins. From 2003 to 2006, 107 (57 years; 30-88) consecutive patients who underwent a lumpectomy for carcinoma with four orientated cavity margins for carcinoma were selected. Preoperative clinical, radiological and histological data, perioperative macroscopic characteristics and definitive histological analysis results were recorded. Lumpectomy or cavity margins were considered as positive when the distance from carcinoma to the margin was less than or equal to 3 mm. Histological examination of cavity margins showed carcinoma in 38 patients (35%), therefore modifying subsequent surgical therapy in 33 cases. Examination of the cavity margins led (1) to avoiding surgical re-excision in 20 cases (lumpectomy margins were positive and the cavity margins negative), (2) to performing a mastectomy or a re-excision in 13 cases (carcinoma was detected in the cavity margins although the lumpectomy margins were negative or tumor size was superior to 3 cm). Between preoperative and perioperative parameters, US scan and macroscopic size of the tumor were predictive factors for positive cavity margins whereas characteristics of the carcinoma determined on biopsy samples and macroscopic status of the lumpectomy margins were not. Our study confirms that the systematic practice of cavity margin resection avoids surgical re-excision and reduces the likelihood of underestimating the extent of the tumor.

17 CFR 242.104 - Stabilizing and other activities in connection with an offering.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation M § 242.104 Stabilizing and other activities in connection with an...

17 CFR 242.105 - Short selling in connection with a public offering.

Code of Federal Regulations, 2011 CFR

2011-04-01

... EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation M § 242.105 Short selling in connection with a public offering. (a) Unlawful...

The Continent-Ocean transition across the Galicia margin: First observations from the Galicia 3D volume

NASA Astrophysics Data System (ADS)

Lymer, Gaël; Cresswell, Derren; Reston, Tim; Stevenson, Carl; Bull, Jon; Sawyer, Dale; Morgan, Julia

2017-04-01

The west Galicia margin has been at the forefront 2D models of breakup subsequently applied to other margins. In summer 2013, a 3D multi-channel seismic dataset was acquired over the Galicia margin with the aim to revisit the margin from a 3D perspective and understand processes of continental extension and break-up through seismic imaging. The volume has been processed through to prestack time migration, followed by depth conversion using velocities extracted from new velocity models based on wide-angle data. Our first interpretations have shown that the most recent block-bounding faults detach downward on a bright reflector, the S reflector, corresponding to a rooted detachment fault and locally the crust-mantle boundary. The 3D topographic and amplitude maps of the S reveal a series of slip surface "corrugations" whose orientation changes oceanward from E-W to ESE-WNW and that we relate to the slip direction during the rifting. We now focus our investigations on the distal part of the S, just east of the Peridotite Ridge, a ridge of exhumed serpentinized mantle. While the S is mainly a continuous surface beneath the continental crust, it suddenly loses its reflectivity oceanward nearby the eastern flank of the ridge. It is likely that the S stops abruptly because it has been offset for almost 1 STWTT by some landward-dipping faults associated with the development of the ridge. This configuration is particularly defendable in the north of the dataset. The implication would be that in this area, the S is shallow and lies below very thin or inexistent basement, thus providing an ideal target for ODP drilling. Alternatively, the S could be intensively segmented by small-offset, but abundant, west-dipping normal faults that root downward on a persistent landward dipping fault that bounds the eastern flank of the ridge. Such a dissection of the S could also explain its lack of reflectivity nearby the ridge; similar reduced reflectivity is locally observed in other parts of the 3D volume in the vicinity of the faults that bound the continental crustal blocks. The implication would be that the S is still located at depth below intensively broken slices of crust and stops against the eastern flank of the Peridotite Ridge. Both cases show that rifting to break-up was a complex and time-variant 3D process that involved several generations of faulting, including late potential landward-dipping structures that controlled the development of the peridotite ridge.

Tutorial on Biostatistics: Linear Regression Analysis of Continuous Correlated Eye Data.

PubMed

Ying, Gui-Shuang; Maguire, Maureen G; Glynn, Robert; Rosner, Bernard

2017-04-01

To describe and demonstrate appropriate linear regression methods for analyzing correlated continuous eye data. We describe several approaches to regression analysis involving both eyes, including mixed effects and marginal models under various covariance structures to account for inter-eye correlation. We demonstrate, with SAS statistical software, applications in a study comparing baseline refractive error between one eye with choroidal neovascularization (CNV) and the unaffected fellow eye, and in a study determining factors associated with visual field in the elderly. When refractive error from both eyes were analyzed with standard linear regression without accounting for inter-eye correlation (adjusting for demographic and ocular covariates), the difference between eyes with CNV and fellow eyes was 0.15 diopters (D; 95% confidence interval, CI -0.03 to 0.32D, p = 0.10). Using a mixed effects model or a marginal model, the estimated difference was the same but with narrower 95% CI (0.01 to 0.28D, p = 0.03). Standard regression for visual field data from both eyes provided biased estimates of standard error (generally underestimated) and smaller p-values, while analysis of the worse eye provided larger p-values than mixed effects models and marginal models. In research involving both eyes, ignoring inter-eye correlation can lead to invalid inferences. Analysis using only right or left eyes is valid, but decreases power. Worse-eye analysis can provide less power and biased estimates of effect. Mixed effects or marginal models using the eye as the unit of analysis should be used to appropriately account for inter-eye correlation and maximize power and precision.

Chapter 34: Geology and petroleum potential of the rifted margins of the Canada Basin

USGS Publications Warehouse

Houseknecht, D.W.; Bird, K.J.

2011-01-01

Three sides of the Canada Basin are bordered by high-standing, conjugate rift shoulders of the Chukchi Borderland, Alaska and Canada. The Alaska and Canada margins are mantled with thick, growth-faulted sediment prisms, and the Chukchi Borderland contains only a thin veneer of sediment. The rift-margin strata of Alaska and Canada reflect the tectonics and sediment dispersal systems of adjacent continental regions whereas the Chukchi Borderland was tectonically isolated from these sediment dispersal systems. Along the eastern Alaska-southern Canada margin, termed herein the 'Canning-Mackenzie deformed margin', the rifted margin is deformed by ongoing Brooks Range tectonism. Additional contractional structures occur in a gravity fold belt that may be present along the entire Alaska and Canada margins of the Canada Basin. Source-rock data inboard of the rift shoulders and regional palaeogeographic reconstructions suggest three potential source-rock intervals: Lower Cretaceous (Hauterivian-Albian), Upper Cretaceous (mostly Turonian) and Lower Palaeogene. Burial history modelling indicates favourable timing for generation from all three intervals beneath the Alaska and Canada passive margins, and an active petroleum system has been documented in the Canning-Mackenzie deformed margin. Assessment of undiscovered petroleum resources indicates the greatest potential in the Canning-Mackenzie deformed margin and significant potential in the Canada and Alaska passive margins. ?? 2011 The Geological Society of London.

Sediment movement and dispersal patterns on the Grand Banks continental shelf and slope were tied to the dynamics of the Laurentide ice-sheet margin

NASA Astrophysics Data System (ADS)

Rashid, H.; MacKillop, K.; Piper, D.; Vermooten, M.; Higgins, J.; Marche, B.; Langer, K.; Brockway, B.; Spicer, H. E.; Webb, M. D.; Fournier, E.

2015-12-01

The expansion and contraction of the late Pleistocene Laurentide ice-sheet (LIS) was the crucial determining factor for the geomorphic features and shelf and slope sediment mobility on the eastern Canadian continental margin, with abundant mass-transport deposits (MTDs) seaward of ice margins on the upper slope. Here, we report for the first time sediment failure and mass-transport deposits from the central Grand Banks slope in the Salar and Carson petroleum basins. High-resolution seismic profiles and multibeam bathymetry show numerous sediment failure scarps in 500-1600 m water depth. There is no evidence for an ice margin on the upper slope younger than MIS 6. Centimeter-scale X-ray fluorescence analysis (XRF), grain size, and oxygen isotope data from piston cores constrain sediment processes over the past 46 ka. Geotechnical measurements including Atterberg limit tests, vane shear measurements and triaxial and multi-stage isotropic consolidation tests allowed us to assess the instability on the continental margin. Cores with continuous undisturbed stratigraphy in contourite silty muds show normal downcore increase in bulk density and undrained peak shear strength. Heinrich (H) layers are identifiable by a marked increase in the bulk density, high Ca (ppm), increase in iceberg-rafted debris and lighter δ18O in the polar planktonic foram Neogloboquadrina pachyderma (sinistral): with a few C-14 dates they provide a robust chronology. There is no evidence for significant supply of sediment from the Grand Banks at the last-glacial maximum. Mass-transport deposits (MTD) are marked by variability in the bulk density, undrained shear strength and little variation in bulk density or Ca (ppm) values. The MTD are older than 46 ka on the central Grand Banks slope, whereas younger MTDs are present in southern Flemish Pass. Factor of safety calculations suggest the slope is statically stable up to gradients of 10°, but more intervals of silty mud may fail during earthquake-induced cyclic loading based on Atterberg tests. By analogy with the Holocene, contourites deposited in MIS 5e may be particularly silty and form a "weak layer" susceptible to failure.

Space-for-time substitution and the evolution of submarine canyons in a passive, progradational margin.

NASA Astrophysics Data System (ADS)

Micallef, Aaron; Ribó, Marta; Canals, Miquel; Puig, Pere; Lastras, Galderic; Tubau, Xavier

2013-04-01

40% of submarine canyons worldwide are located in passive margins, where they constitute preferential conduits of sediment and biodiversity hotspots. Recent studies have presented evidence that submarine canyons incising passive, progradational margins can co-evolve with the adjacent continental slope during long-term margin construction. The stages of submarine canyon initiation and their development into a mature canyon-channel system are still poorly constrained, however, which is problematic when attempting to reconstruct the development of passive continental margins. In this study we analyse multibeam echosounder and seismic reflection data from the southern Ebro margin (western Mediterranean Sea) to document the stages through which a first-order gully develops into a mature, shelf-breaching canyon and, finally, into a canyon-channel system. This morphological evolution allows the application of a space-for-time substitution approach. Initial gully growth on the continental slope takes place via incision and downslope elongation, with limited upslope head retreat. Gravity flows are the main driver of canyon evolution, whereas slope failures are the main agent of erosion; they control the extent of valley widening, promote tributary development, and their influence becomes more significant with time. Breaching of the continental shelf by a canyon results in higher water/sediment loads that enhance canyon development, particularly in the upper reaches. Connection of the canyon head with a paleo-river changes evolution dynamics significantly, promoting development of a channel and formation of depositional landforms. Morphometric analyses demonstrate that canyons develop into geometrically self-similar systems that approach steady-state and higher drainage efficiency. Canyon activity in the southern Ebro margin is pulsating and enhanced during sea level lowstands. Rapid sedimentation by extension of the palaeo-Millars River into the outermost shelf and upper slope is inferred as the source of gravity flows driving canyon evolution. Canyon morphology is shown to be maintained over the course of more than one fall and rise in sea-level. Our model of canyon evolution is applicable to other passive margins (e.g. Argentine continental margin).

Submarine fans: Characteristics, models, classification, and reservoir potential

NASA Astrophysics Data System (ADS)

Shanmugam, G.; Moiola, R. J.

1988-02-01

Submarine-fan sequences are important hydrocarbon reservoirs throughout the world. Submarine-fan sequences may be interpreted from bed-thickness trends, turbidite facies associations, log motifs, and seismic-reflection profiles. Turbidites occurring predominantly in channels and lobes (or sheet sands) constitute the major portion of submarine-fan sequences. Thinning- and thickening-upward trends are suggestive of channel and lobe deposition, respectively. Mounded seismic reflections are commonly indicative of lower-fan depositional lobes. Fan models are discussed in terms of modern and ancient fans, attached and detached lobes, highly efficient and poorly efficient systems, and transverse and longitudinal fans. In general, depositional lobes are considered to be attached to feeder channels. Submarine fans can be classified into four types based on their tectonic settings: (1) immature passive-margin fans (North Sea type); (2) mature passive-margin fans (Atlantic type); (3) active-margin fans (Pacific type); and (4) mixed-setting fans. Immature passive-margin fans (e.g., Balder, North Sea), and active-margin fans (e.g., Navy, Pacific Ocean) are usually small, sand-rich, and possess well developed lobes. Mature passive-margin fans (e.g., Amazon, Atlantic Ocean) are large, mud-rich, and do not develop typical lobes. However, sheet sands are common in the lower-fan regions of mature passive-margin fans. Mixed-setting fans display characteristics of either Atlantic type (e.g., Bengal, Bay of Bengal), or Pacific type (Orinoco, Caribbean), or both. Conventional channel-lobe models may not be applicable to fans associated with mature passive margins. Submarine fans develop primarily during periods of low sea level on both active- and passive-margin settings. Consequently, hydrocarbon-bearing fan sequences are associated generally with global lowstands of sea level. Channel-fill sandstones in most tectonic settings are potential reservoirs. Lobes exhibit the most favorable reservoir quality in terms of sand content, lateral continuity, and porosity development. Lower-fan sheet sands may also make good reservoirs. Quartz-rich sandstones of mature passive-margin fans are most likely to preserve depositional porosity, whereas lithic sandstones of active-margin fans may not.

In-situ fractional crystallization as a major mechanism in differentiation of Karaj sill, northern Iran

NASA Astrophysics Data System (ADS)

Maghdour-Mashhour, Reza; Esmaeily, Dariush

2010-05-01

During the upper Eocene-Oligocene, the Karaj Dam basement sill (KDBS), located within the E-W-trending Alborz range in northern Iran, intruded the middle and upper tuff units of the Karaj Formation. The KDBS consists of a layered series between upper and lower chilled margins, with local fine-grained monzonitic dykes. The rocks of the chilled margins are gabbroic in composition and show porphyritic texture. The rocks show a continuous transition from porphyritic to equigranular texture toward the center of the sill. Most of the KDBS is medium to coarse grained, showing magmatic layering defined by modal variations in pyroxene and plagioclase, the main constituent minerals. The layered series, dominated by gabbro, diorite, and monzodiorite, formed almost upward from the lower to the upper chilled margin, with gradational transitions between rock types. The KDBS shows an S-shaped profile of MgO concentration from the base to the top of the sill. In situ crystallization is indicated by an approximately constant modal abundance of pyroxene and plagioclase, a narrow range of major element contents in the main lithologies (e.g., 49-54 wt% SiO2, 17-19 wt% Al2O3, and 2.7-5.2 wt% MgO), and variable trace element concentrations (e.g., 500-1150 ppm Ba, 45-130 ppm Rb, 150-720ppm Sr, and 50-160 ppm Zr). Disequilibrium crystallization, caused by Soret fractionation in the marginal series, is indicated by an unexpected overall enrichment trend in MgO concentration and Mg# of pyroxenes from the chilled margin (olivine-bearing gabbro) to marginal gabbro. Formation of chilled margins form an effective insulating layer between contacts and overlaying hot, turbulent magma causing magma cool considerably slowly and have sufficient time to produce different differentiated sequence by in-situ nucleation and growth from gabbro to diorite and monzodiorite. Following the formation of chilled margins, the parent magma composition was established on the Plg-Cpx cotectic line of the Ol-Plg-Cpx ternary system or in the Plg field of the Cpx-Ab-An phase system. In the latter system, Plg starts to crystallize in mushy layers and its composition changes from anorthite to albite until reaching the cotectic line, at which point Cpx starts to form. The presence of plagioclase laths as inclusions within large crystals of clinopyroxene indicates cotectic crystallization and the early crystallization of Plg during formation of the gabbroic unit. Subsequently, the liquid line of descent followed the cotectic line toward the Ab-Cpx eutectic point. During this process, gabbroic cumulate formed at the solidified margins of the magma chamber. After the formation of Plg-Cpx cumulate, the evolved interstitial liquid, which had undergone chemical fractionation, migrated out of the gabbroic cumulate pile within the main magma body, thereby changing the composition of the magma reservoir. Consequently, the melt composition would have been different from the initial melt, being more evolved. The subsequent evolution of the liquid line of descent of compositionally new melt followed the same path at every stage of the formation of new melt; the An% of plagioclase decreased and Ab% increased to approximately 40%. In addition, the Cpx content showed a gradual decrease. Eventually, the Plg accumulates as dioritic cumulate in solidified margins of the chamber. Subsequently, the composition of the main magma changed, approaching the eutectic point of the Or-Ab solid solution binary system. in time, at the eutectic point, Kf started to crystallize and formed monzodiorites downward from the roof of the magma chamber during the final stages of differentiation. Although gravitational crystal settling contributed to the evolution of these rocks, it is not considered to have been a major factor in the development of the observed layering.

Highlights and Opportunities from Continuous Access to Gas Hydrates Sites at Ocean Networks Canada's NEPTUNE Observatory

NASA Astrophysics Data System (ADS)

Scherwath, M.; Heesemann, M.; Riedel, M.; Thomsen, L.; Roemer, M.; Chatzievangelou, D.; Purser, A.

2017-12-01

Since 2009 Ocean Networks Canada provides permanent access and continuous data in near real-time from two prominent gas hydrates research sites at the Northern Cascadia Margin, Barkley Canyon and Clayoquot Slope off Vancouver Island, through power and communication cables directly from shore. We show data highlights from the seafloor crawler Wally, the world's first internet operated vehicle, in a field of hydrate mounds and outcropping gas hydrates, and its co-located sonars and state-of-the-ocean sensors and Barkley Canyon. For example, spectacular views from the benthic communities and their changes over time are captured by video. At Clayoquot Slope highly active gas seep fields are monitored with a rotating multibeam sonar and various other environmental sensors. In addition, newly installed geodetic sensors as well as an instrumented borehole in that area are now online and provide additional data on subduction-related deformation and potential links to gas discharge. These show-case examples highlight the benefits of co-located experiments that enable interdisciplinary research and also the ability for high-power and -bandwidth long-term monitoring at remote seafloor locations, that over time will provide baselines for environmental monitoring together with natural variability and potential long-term trends.

Encoding of marginal utility across time in the human brain

PubMed Central

Pine, Alex; Seymour, Ben; Roiser, Jonathan P; Bossaerts, Peter; Friston, Karl J.; Curran, H. Valerie; Dolan, Raymond J.

2010-01-01

Marginal utility theory prescribes the relationship between the objective property of the magnitude of rewards and their subjective value. Despite its pervasive influence, however, there is remarkably little direct empirical evidence for such a theory of value, let alone of its neurobiological basis. We show that human preferences in an inter-temporal choice task are best described by a model that integrates marginally diminishing utility with temporal discounting. Using functional magnetic resonance imaging (fMRI), we show that activity in the dorsal striatum encodes both the marginal utility of rewards, over and above that which can be described by their magnitude alone, and the discounting associated with increasing time. In addition, our data show that dorsal striatum may be involved in integrating subjective valuation systems inherent to time and magnitude, thereby providing an overall metric of value used to guide choice behaviour. Furthermore, during choice we show that anterior cingulate activity correlates with the degree of difficulty associated with dissonance between value and time. Our data support an integrative architecture for decision-making, revealing the neural representation of distinct subcomponents of value that may contribute to impulsivity and decisiveness. PMID:19641120

Cutting blade dentitions in squaliform sharks form by modification of inherited alternate tooth ordering patterns

PubMed Central

Smith, Moya Meredith

2016-01-01

The squaliform sharks represent one of the most speciose shark clades. Many adult squaliforms have blade-like teeth, either on both jaws or restricted to the lower jaw, forming a continuous, serrated blade along the jaw margin. These teeth are replaced as a single unit and successor teeth lack the alternate arrangement present in other elasmobranchs. Micro-CT scans of embryos of squaliforms and a related outgroup (Pristiophoridae) revealed that the squaliform dentition pattern represents a highly modified version of tooth replacement seen in other clades. Teeth of Squalus embryos are arranged in an alternate pattern, with successive tooth rows containing additional teeth added proximally. Asynchronous timing of tooth production along the jaw and tooth loss prior to birth cause teeth to align in oblique sets containing teeth from subsequent rows; these become parallel to the jaw margin during ontogeny, so that adult Squalus has functional tooth rows comprising obliquely stacked teeth of consecutive developmental rows. In more strongly heterodont squaliforms, initial embryonic lower teeth develop into the oblique functional sets seen in adult Squalus, with no requirement to form, and subsequently lose, teeth arranged in an initial alternate pattern. PMID:28018617

Vesiculation Processes During Transient and Sustained Explosive Activity at Halema'uma'u Crater, Kīlauea in 2008-2013.

NASA Astrophysics Data System (ADS)

Houghton, B. F.; Orr, T. R.; Taddeucci, J.; Carey, R.; Del Bello, E.; Scarlato, P.; Patrick, M. R.

2015-12-01

The 2008-2015 summit eruption within Halema'uma'u crater, Kilauea has been characterized by alternations of passive degassing with two styles of explosive activity, both frequently triggered by rock falls that perturb the free surface of magma in the vent. In the first, larger rock falls trigger second vesiculation of magma at depths up to 100 m below the free surface ejecting juvenile bomb and lapilli populations of very variable vesicularity. The second, the topic of this presentation, consists of intervals of minutes to tens-of-minutes duration of low fountaining activity often from multiple locations. Vents may migrate with time, first across the free surface to its margins, and then around the margins, in response to convection processes in the underlying melt. Analysis of short sequences of high-speed, high-resolution video footage shows that the sustained fountaining is maintained by not by a continuous discharge but rather by closely spaced bursting of two-to-five meter-wide bubbles. Bubbles accelerate through the free surface at velocities of 10 to 40 m/s disrupting the viscoelastic crust and forming large fall-back, lacework pyroclasts and smaller highly vesicular bombs and lapilli.

Cutting blade dentitions in squaliform sharks form by modification of inherited alternate tooth ordering patterns

NASA Astrophysics Data System (ADS)

Underwood, Charlie; Johanson, Zerina; Smith, Moya Meredith

2016-11-01

The squaliform sharks represent one of the most speciose shark clades. Many adult squaliforms have blade-like teeth, either on both jaws or restricted to the lower jaw, forming a continuous, serrated blade along the jaw margin. These teeth are replaced as a single unit and successor teeth lack the alternate arrangement present in other elasmobranchs. Micro-CT scans of embryos of squaliforms and a related outgroup (Pristiophoridae) revealed that the squaliform dentition pattern represents a highly modified version of tooth replacement seen in other clades. Teeth of Squalus embryos are arranged in an alternate pattern, with successive tooth rows containing additional teeth added proximally. Asynchronous timing of tooth production along the jaw and tooth loss prior to birth cause teeth to align in oblique sets containing teeth from subsequent rows; these become parallel to the jaw margin during ontogeny, so that adult Squalus has functional tooth rows comprising obliquely stacked teeth of consecutive developmental rows. In more strongly heterodont squaliforms, initial embryonic lower teeth develop into the oblique functional sets seen in adult Squalus, with no requirement to form, and subsequently lose, teeth arranged in an initial alternate pattern.

Traction alopecia: the root of the problem.

PubMed

Billero, Victoria; Miteva, Mariya

2018-01-01

Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. TA can also occur in the setting of religious and occupational traumatic hairstyling. In its later stages, the disease may progress into an irreversible scarring alopecia if traumatic hairstyling continues without appropriate intervention. The most common clinical presentation includes marginal alopecia and non-marginal patchy alopecia. A clue to the clinical diagnosis is the preservation of the fringe sign as opposed to its loss in frontal fibrosing alopecia (FFA). Dermoscopy can be helpful in the diagnosis and can detect the ongoing traction by the presence of hair casts. Histopathology can distinguish TA from alopecia areata, FFA, and patchy central centrifugal cicatricial alopecia. Currently, there is no cure. Therefore, it is imperative that clinicians educate high-risk populations about TA and those practices that may convey the risk of hair loss.

SU-E-J-188: Theoretical Estimation of Margin Necessary for Markerless Motion Tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, R; Block, A; Harkenrider, M

2015-06-15

Purpose: To estimate the margin necessary to adequately cover the target using markerless motion tracking (MMT) of lung lesions given the uncertainty in tracking and the size of the target. Methods: Simulations were developed in Matlab to determine the effect of tumor size and tracking uncertainty on the margin necessary to achieve adequate coverage of the target. For simplicity, the lung tumor was approximated by a circle on a 2D radiograph. The tumor was varied in size from a diameter of 0.1 − 30 mm in increments of 0.1 mm. From our previous studies using dual energy markerless motion tracking,more » we estimated tracking uncertainties in x and y to have a standard deviation of 2 mm. A Gaussian was used to simulate the deviation between the tracked location and true target location. For each size tumor, 100,000 deviations were randomly generated, the margin necessary to achieve at least 95% coverage 95% of the time was recorded. Additional simulations were run for varying uncertainties to demonstrate the effect of the tracking accuracy on the margin size. Results: The simulations showed an inverse relationship between tumor size and margin necessary to achieve 95% coverage 95% of the time using the MMT technique. The margin decreased exponentially with target size. An increase in tracking accuracy expectedly showed a decrease in margin size as well. Conclusion: In our clinic a 5 mm expansion of the internal target volume (ITV) is used to define the planning target volume (PTV). These simulations show that for tracking accuracies in x and y better than 2 mm, the margin required is less than 5 mm. This simple simulation can provide physicians with a guideline estimation for the margin necessary for use of MMT clinically based on the accuracy of their tracking and the size of the tumor.« less

A novel method to quantify and compare anatomical shape: application in cervix cancer radiotherapy

NASA Astrophysics Data System (ADS)

Oh, Seungjong; Jaffray, David; Cho, Young-Bin

2014-06-01

Adaptive radiation therapy (ART) had been proposed to restore dosimetric deficiencies during treatment delivery. In this paper, we developed a technique of Geometric reLocation for analyzing anatomical OBjects' Evolution (GLOBE) for a numerical model of tumor evolution under radiation therapy and characterized geometric changes of the target using GLOBE. A total of 174 clinical target volumes (CTVs) obtained from 32 cervical cancer patients were analyzed. GLOBE consists of three main steps; step (1) deforming a 3D surface object to a sphere by parametric active contour (PAC), step (2) sampling a deformed PAC on 642 nodes of icosahedron geodesic dome for reference frame, and step (3) unfolding 3D data to 2D plane for convenient visualization and analysis. The performance was evaluated with respect to (1) convergence of deformation (iteration number and computation time) and (2) accuracy of deformation (residual deformation). Based on deformation vectors from planning CTV to weekly CTVs, target specific (TS) margins were calculated on each sampled node of GLOBE and the systematic (Σ) and random (σ) variations of the vectors were calculated. Population based anisotropic (PBA) margins were generated using van Herk's margin recipe. GLOBE successfully modeled 152 CTVs from 28 patients. Fast convergence was observed for most cases (137/152) with the iteration number of 65 ± 74 (average ± STD) and the computation time of 13.7 ± 18.6 min. Residual deformation of PAC was 0.9 ± 0.7 mm and more than 97% was less than 3 mm. Margin analysis showed random nature of TS-margin. As a consequence, PBA-margins perform similarly to ISO-margins. For example, PBA-margins for 90% patients' coverage with 95% dose level is close to 13 mm ISO-margins in the aspect of target coverage and OAR sparing. GLOBE demonstrates a systematic analysis of tumor motion and deformation of patients with cervix cancer during radiation therapy and numerical modeling of PBA-margin on 642 locations of CTV surface.

Combined risk assessment of nonstationary monthly water quality based on Markov chain and time-varying copula.

PubMed

Shi, Wei; Xia, Jun

2017-02-01

Water quality risk management is a global hot research linkage with the sustainable water resource development. Ammonium nitrogen (NH 3 -N) and permanganate index (COD Mn ) as the focus indicators in Huai River Basin, are selected to reveal their joint transition laws based on Markov theory. The time-varying moments model with either time or land cover index as explanatory variables is applied to build the time-varying marginal distributions of water quality time series. Time-varying copula model, which takes the non-stationarity in the marginal distribution and/or the time variation in dependence structure between water quality series into consideration, is constructed to describe a bivariate frequency analysis for NH 3 -N and COD Mn series at the same monitoring gauge. The larger first-order Markov joint transition probability indicates water quality state Class V w , Class IV and Class III will occur easily in the water body of Bengbu Sluice. Both marginal distribution and copula models are nonstationary, and the explanatory variable time yields better performance than land cover index in describing the non-stationarities in the marginal distributions. In modelling the dependence structure changes, time-varying copula has a better fitting performance than the copula with the constant or the time-trend dependence parameter. The largest synchronous encounter risk probability of NH 3 -N and COD Mn simultaneously reaching Class V is 50.61%, while the asynchronous encounter risk probability is largest when NH 3 -N and COD Mn is inferior to class V and class IV water quality standards, respectively.

Two new species of the genus Haplotropis Saussure, 1888 (Orthoptera, Acridoidea, Pamphagidae) from China.

PubMed

Ye, Bao-Hua; Yin, Zhan; Li, Xin-Jiang

2016-06-30

Two new species of the genus Haplotropis Saussure, 1888 from China are described in this paper. The new species Haplotropis xiai sp. nov. is similar to Haplotropis brunneriana Saussure, 1888, but differs from latter by frontal ridge of male widened at median ocellus; tegmina narrower, cover 2/5 tympanum; cercus of male apical half part gently tapering; lower margin of epiphallus with high projection in the middle; anterior margin of pronotum in female with distinct acute angular in middle; length of subgenital plate shorter than width in female. The Haplotropis zhuoluensis sp. nov. is similar to Haplotropis xiai sp. nov., but differs from latter by anterior margin of pronotum reaching hind margin of eyes; length of temina is 1.6 times in male and 1.3 times in female of width; length of interspace shorter than narrowest in mesosternum of male; ancorae of epiphallus oblique inward distinctly, lower margin with high projection in the middle; length of subgenital plate longer than width in female. Type specimens are deposited in the College of Life Sciences, Hebei University, Baoding, China.

Timing of mafic magmatism VS localization of the deformation: the Ivrea Zone (Italian Alps)

NASA Astrophysics Data System (ADS)

Bidault, M.; Geoffroy, L.; Arbaret, L.; Aubourg, C. T.

2017-12-01

Mafic magma emplacement is a common feature of continental extension systems, represented at initial stage by volcanic rifts and at more mature stage by volcanic passive margins. In those contexts, lithospheric extension is not isovolumic, magma being notably added to the crust while it is tectonically stretched and thinned. Crystal-scale power-law mechanisms responsible for the continuous flow of the lower crust during extension are composition- and temperature-dependent and additionally, very slow processes. However magma emplacement is a very rapid process. Its effect on the lower crust rheology is dual depending upon the time-scale of the processes: thermal weakening, when newly-formed hot intrusions emplace and heat their surrounding, and rheological chemical hardening when mafic intrusions are cold. Consequently, the localization and type of ductile deformation affecting the lower crust depend on the emplacement rate, volume and spatial organization of the mafic system. The Ivrea Zone is a well-known variscan continental crust section that underwent extension through first gravitational collapse in the Carboniferous and then lithospheric extension until the Permian. From the Late Carboniferous to the Permian, extension in the Ivrea Zone was associated with large volumes of magma intrusion within the lower crust. This volcanic rift stage predated the development of a non-volcanic passive margin during the Jurassic. The entire system was tilted 90° eastward during the Alpine orogeny but remained unaffected by significant metamorphism or pervasive strain. We combine new field observations, Anisotropy of Magnetic Susceptibility data and trace-element geochemistry to investigate the timing, tectonic-setting and consequences of magma emplacement in the in-extension Ivrea lower crust. We propose a new tectonic history, highlighting time-dependent strain transfer and localization in the lower crust, in connection with mafic magma intrusion.

Kinematic Reconstruction of the Costa Rican Margin: Evidence for Discontinuities in Deformation Across the Margin

NASA Astrophysics Data System (ADS)

Gose, B.; Bangs, N. L.; McIntosh, K. D.

2016-12-01

Recently acquired 3D seismic reflection data shows that both in-sequence and out-of sequence faults makeup the interior structure of the Costa Rican convergent margin. Recent studies have found evidence for a phase of accretion that led to the formation of a series of thrust-bounded folds that are easily observable within the margin-wedge fabric. Along a primary 2D transect through the center of the 3D survey, faults partition the outer 23km of the margin into 8 fault-bounded segments that can be divided into two characteristic zones, those closest to the trench (S1-S3) and those furthest (S4-S8) separated by a slope break 10 km from the trench (Fig 1). To better understand the observed structure, each segment was characterized as a fault-propagation fold and geometrically modeled using Paradigm's Geosec 2D software. Kinematic flexural slip modules were applied in order to perform bed-length balancing and generate a geologic reconstruction of the margin. Results show the section of the margin spanning from 3-23km from the deformation front has experienced 27.5% shortening, assuming the interpreted horizons were initially flat and continuous. The individual values for percent shortening are not consistent across the margin but distributed into two zones each with progressively increasing strain in the landward direction. Zone 2 (landward) begins with a percent shortening for S8 at 22% and linearly decreases to 2% shortening as you move seaward to S4. The Zone 1-2 boundary is marked by a slope break coinciding with an increase in percent shortening (S3,15%) followed by less shortening seaward (9%, 8%). Shortening and the associated strain is focused at the landward side of the two zones, within S3 and S8. We conclude that the Costa Rican margin has some degree of mechanical partitioning, with a notable discontinuity in strain patterns occurring 10 km from the trench.

Post-Jurassic tectonic evolution of Southeast Asia

NASA Astrophysics Data System (ADS)

Zahirovic, Sabin; Seton, Maria; Dietmar Müller, R.; Flament, Nicolas

2014-05-01

The accretionary growth of Asia, linked to long-term convergence between Eurasia, Gondwana-derived blocks and the Pacific, resulted in a mosaic of terranes for which conflicting tectonic interpretations exist. Here, we propose solutions to a number of controversies related to the evolution of Sundaland through a synthesis of published geological data and plate reconstructions that reconcile both geological and geophysical constraints with plate driving forces. We propose that West Sulawesi, East Java and easternmost Borneo rifted from northern Gondwana in the latest Jurassic, collided with an intra-oceanic arc at ~115 Ma and subsequently sutured to Sundaland by 80 Ma. Although recent models argue that the Southwest Borneo core accreted to Sundaland at this time, we use volcanic and biogeographic constraints to show that the core of Borneo was on the Asian margin since at least the mid Jurassic. This northward transfer of Gondwana-derived continental fragments required a convergent plate boundary in the easternmost Tethys that we propose gave rise to the Philippine Archipelago based on the formation of latest Jurassic-Early Cretaceous supra-subduction zone ophiolites on Halmahera, Obi Island and Luzon. The Late Cretaceous marks the shift from Andean-style subduction to back-arc opening on the east Asian margin. Arc volcanism along South China ceased by ~60 Ma due to the rollback of the Izanagi slab, leading to the oceanward migration of the volcanic arc and the opening of the Proto South China Sea (PSCS). We use the Apennines-Tyrrhenian system in the Mediterranean as an analogue to model this back-arc. Continued rollback detaches South Palawan, Mindoro and the Semitau continental blocks from the stable east Asian margin and transfers them onto Sundaland in the Eocene to produce the Sarawak Orogeny. The extrusion of Indochina and subduction polarity reversal along northern Borneo opens the South China Sea and transfers the Dangerous Grounds-Reed Bank southward to terminate PSCS south-dipping subduction and culminates in the Sarawak Orogeny on Borneo and ophiolite obduction on Palawan. We account for the regional plate reorganizations related to the initiation of Pacific subduction along the Izu-Bonin-Mariana Arc, the extrusion tectonics resulting from the India-Eurasia collision, and the shift from basin extension to inversion on Sundaland as an indicator of collision between the Australian continent and the active Asian margin. We generate continuously closing and evolving plate boundaries, seafloor age-grids and global plate velocity fields using the open-source and cross-platform GPlates plate reconstruction software. We link our plate motions to numerical mantle flow models in order to predict mantle structure at present-day that can be qualitatively compared to P- and S- wave seismic tomography models. This method allows us to analyse the evolution of the mantle related to Tethyan and Pacific subduction and to test alternative plate reconstructions. This iterative approach can be used to improve plate reconstructions in the absence of preserved seafloor and conjugate passive margins of continental blocks, which may have been destroyed or highly deformed by multiple episodes of accretion along the Asian margins.

Development of genetic diversity, differentiation and structure over 500 years in four ponderosa pine populations.

PubMed

Lesser, M R; Parchman, T L; Jackson, S T

2013-05-01

Population history plays an important role in shaping contemporary levels of genetic variation and geographic structure. This is especially true in small, isolated range-margin populations, where effects of inbreeding, genetic drift and gene flow may be more pronounced than in large continuous populations. Effects of landscape fragmentation and isolation distance may have implications for persistence of range-margin populations if they are demographic sinks. We studied four small, disjunct populations of ponderosa pine over a 500-year period. We coupled demographic data obtained through dendroecological methods with microsatellite data to discern how and when contemporary levels of allelic diversity, among and within-population levels of differentiation, and geographic structure, arose. Alleles accumulated rapidly following initial colonization, demonstrating proportionally high levels of gene flow into the populations. At population sizes of approximately 100 individuals, allele accumulation saturated. Levels of genetic differentiation among populations (F(ST) and Jost's D(est)) and diversity within populations (F(IS)) remained stable through time. There was no evidence of geographic genetic structure at any time in the populations' history. Proportionally, high gene flow in the early stages of population growth resulted in rapid accumulation of alleles and quickly created relatively homogenous genetic patterns among populations. Our study demonstrates that contemporary levels of genetic diversity were formed quickly and early in population development. How contemporary genetic diversity accumulates over time is a key facet of understanding population growth and development. This is especially relevant given the extent and speed at which species ranges are predicted to shift in the coming century. © 2013 Blackwell Publishing Ltd.

Reconstruction of the Exhumed Mantle Across the North Iberian Margin by Crustal-Scale 3-D Gravity Inversion and Geological Cross Section

NASA Astrophysics Data System (ADS)

Pedrera, A.; García-Senz, J.; Ayala, C.; Ruiz-Constán, A.; Rodríguez-Fernández, L. R.; Robador, A.; González Menéndez, L.

2017-12-01

Recent models support the view that the Pyrenees were formed after the inversion of a previously highly extended continental crust that included exhumed upper mantle rocks. Mantle rocks remain near to the surface after compression and mountain building, covered by the latest Cretaceous to Paleogene sequences. 3-D lithospheric-scale gravity inversion demands the presence of a high-density mantle body placed within the crust in order to justify the observed anomalies. Exhumed mantle, having 50 km of maximum width, continuously extends beneath the Basque-Cantabrian Basin and along the northern side of the Pyrenees. The association of this body with rift, postrift, and inversion structural geometries is tested in a balanced cross section across the Basque-Cantabrian Basin that incorporates a major south-dipping ramp-flat-ramp extensional detachment active between Valanginian and early Cenomanian times. Results indicate that horizontal extension progressed 48 km at variable strain rates that increased from 1 to 4 mm/yr in middle Albian times. Low-strength Triassic Keuper evaporites and mudstones above the basement favor the decoupling of the cover with formation of minibasins, expulsion rollovers, and diapirs. The inversion of the extensional system is accommodated by doubly verging basement thrusts due to the reactivation of the former basin bounding faults in Eocene-Oligocene times. Total shortening is estimated in 34 km and produced the partial subduction of the continental lithosphere beneath the two sides of the exhumed mantle. Obtained results help to pinpoint the original architecture of the North Iberian Margin and the evolution of the hyperextended aborted intracontinental basins.

Absolute Plate Motion Control Since the Triassic from the Cocos Slab and its Associated Subduction Record in Mexico

NASA Astrophysics Data System (ADS)

Boschman, L.; Van Hinsbergen, D. J. J.; Langereis, C. G.; Molina-Garza, R. S.; Kimbrough, D. L.; Spakman, W.

2017-12-01

A positive wave speed anomaly interpreted as the Cocos slab stretches from the uppermost mantle at the Middle America trench in the west, to the lowermost mantle below the Atlantic in the east. The length and continuity of this slab indicates long-lived, uninterrupted eastward subduction of the attached Cocos Plate and its predecessor, the Farallon Plate. The geological record of Mexico contains Triassic to present day evidence of subduction, of which the post-Late Cretaceous phase is of continental margin-style. Interpretations of the pre-Upper Cretaceous subduction-related rock assemblages are under debate, and vary from far-travelled exotic intra-oceanic island arc character to in-situ extended continental margin origin. We present new paleomagnetic data that show that Triassic, Jurassic and Cretaceous subduction-related rocks from the Vizcaíno Peninsula and the Guerrero terrane have a paleolatitudinal plate motion history that is equal to that of the North American continent. This suggests that these rock assemblages were part of the overriding plate and were perhaps only separated from the North American continent by temporal fore- or back-arc spreading. The entire Triassic-present day subduction record, and hence, reconstructed trench location, can therefore be linked to the Cocos slab, which provides control on longitudinal plate motion of North America since the time of Pangea. Compared to the latest state of the art mantle frames, in which longitudes are essentially unconstrained for pre-Cretaceous times, our reconstructed absolute position of North America requires a significant westward longitudinal shift for Mesozoic times.

Development of the Canadian Marginalization Index: a new tool for the study of inequality.

PubMed

Matheson, Flora I; Dunn, James R; Smith, Katherine L W; Moineddin, Rahim; Glazier, Richard H

2012-04-30

Area-based measures of socio-economic status are increasingly used in population health research. Based on previous research and theory, the Canadian Marginalization Index (CAN-Marg) was created to reflect four dimensions of marginalization: residential instability, material deprivation, dependency and ethnic concentration. The objective of this paper was threefold: to describe CAN-Marg; to illustrate its stability across geographic area and time; and to describe its association with health and behavioural problems. CAN-Marg was created at the dissemination area (DA) and census tract level for census years 2001 and 2006, using factor analysis. Descriptions of 18 health and behavioural problems were selected using individual-level data from the Canadian Community Health Survey (CCHS) 3.1 and 2007/08. CAN-Marg quintiles created at the DA level (2006) were assigned to individual CCHS records. Multilevel logistic regression modeling was conducted to examine associations between marginalization and CCHS health and behavioural problems. The index demonstrated marked stability across time and geographic area. Each of the four dimensions showed strong and significant associations with the selected health and behavioural problems, and these associations differed depending on which of the dimensions of marginalization was examined. CAN-Marg is a census-based, empirically derived and theoretically informed tool designed to reflect a broader conceptualization of Canadian marginalization.

Tumor margin detection using optical biopsy techniques

NASA Astrophysics Data System (ADS)

Zhou, Yan; Liu, Cheng-hui; Li, Jiyou; Li, Zhongwu; Zhou, Lixin; Chen, Ke; Pu, Yang; He, Yong; Zhu, Ke; Li, Qingbo; Alfano, Robert R.

2014-03-01

The aim of this study is to use the Resonance Raman (RR) and fluorescence spectroscopic technique for tumor margin detection with high accuracy based on native molecular fingerprints of breast and gastrointestinal (GI) tissues. This tumor margins detection method utilizes advantages of RR spectroscopic technique in situ and in real-time to diagnose tumor changes providing powerful tools for clinical guiding intraoperative margin assessments and postoperative treatments. The tumor margin detection procedures by RR spectroscopy were taken by scanning lesion from center or around tumor region in ex-vivo to find the changes in cancerous tissues with the rim of normal tissues using the native molecular fingerprints. The specimens used to analyze tumor margins include breast and GI carcinoma and normal tissues. The sharp margin of the tumor was found by the changes of RR spectral peaks within 2 mm distance. The result was verified using fluorescence spectra with 300 nm, 320 nm and 340 nm excitation, in a typical specimen of gastric cancerous tissue within a positive margin in comparison with normal gastric tissues. This study demonstrates the potential of RR and fluorescence spectroscopy as new approaches with labeling free to determine the intraoperative margin assessment.

3-D Structure and Morphology of the S-reflector Detachment Fault, Offshore Galicia, Spain

NASA Astrophysics Data System (ADS)

Schuba, C. N.; Sawyer, D. S.; Gray, G. G.; Morgan, J.; Bull, J.; Shillington, D. J.; Jordan, B.; Reston, T. J.

2017-12-01

The crustal architecture of passive continental margins provides valuable clues for understanding rift initiation and evolution. The Galicia margin is an archetypal magma-poor margin displaying exhumed serpentinized mantle, and is an optimal setting in which to examine rift-related processes. A new 3-D seismic reflection volume images this margin in great detail. The S-reflector detachment fault, one of the most prominent structural features associated with the Galicia margin, is imaged as a continuous interface over an area of 600 km2. The top and base of the fault zone can be mapped independently, which enables seismic attribute analysis of this significant structure. RMS amplitude maps extracted from this interface show localized patches of high amplitude stripes that coincide with thickness variations of the fault zone and undulations in the bounding surfaces of the fault. These variations bear similarities to grooves on the fault surface such as slickensides, and appear to have developed as the fault zone evolved. These features thus represent good indicators of the kinematics of the fault system. In general, there is good correlation between S-reflector morphology and the overriding fault intersections; however this relationship does not appear to be present with the fault gouge thickness.

A comparison of the regional slope characteristics of Venus and earth - Implications for geologic processes on Venus

NASA Technical Reports Server (NTRS)

Sharpton, V. L.; Head, J. W., III

1986-01-01

The range of 3 degree by 3 degree regional slopes of the Earth and Venus is similar (approximately 0.0-2.4 degrees), although the surface distribution of these values differs significantly. On earth, cratonic and abyssal plains form extensive regions of 0.0 degree slope. Within these regions a variety of features (mid-ocean ridges, volcanic island chains, subduction zones, and floded mountains) have regional slope characteristics influenced by seafloor spreading and plate recycling, as well as an active weathering regime. The plains provinces of Venus are much more rugged than earth's plains and are marked by numerous closely spaced circular and linear features (0.1-0.2 degree regional slope) concentrated into broad linear zones of global extent. Although Venus highlands are bounded by narrow zones of relatively steep slope, the margins of Aphrodite Terra and Beta Regio are not as steep as earth's continental margins and appear to be best developed parallel to the trends of major chasmata within these regions. Ishtar Terra's margins are significantly steeper and more continuous than other highland margins and are comparable to passive margins on earth. The Venus highlands do not contain appreciable smooth, flat interior regions, implying that highland topography is not significantly modified by erosion or deposition.

Multiple-choice tests stabilize access to marginal knowledge.

PubMed

Cantor, Allison D; Eslick, Andrea N; Marsh, Elizabeth J; Bjork, Robert A; Bjork, Elizabeth Ligon

2015-02-01

Marginal knowledge refers to knowledge that is stored in memory, but is not accessible at a given moment. For example, one might struggle to remember who wrote The Call of the Wild, even if that knowledge is stored in memory. Knowing how best to stabilize access to marginal knowledge is important, given that new learning often requires accessing and building on prior knowledge. While even a single opportunity to restudy marginal knowledge boosts its later accessibility (Berger, Hall, & Bahrick, 1999), in many situations explicit relearning opportunities are not available. Our question is whether multiple-choice tests (which by definition expose the learner to the correct answers) can also serve this function and, if so, how testing compares to restudying given that tests can be particularly powerful learning devices (Roediger & Karpicke, 2006). In four experiments, we found that multiple-choice testing had the power to stabilize access to marginal knowledge, and to do so for at least up to a week. Importantly, such tests did not need to be paired with feedback, although testing was no more powerful than studying. Overall, the results support the idea that one's knowledge base is unstable, with individual pieces of information coming in and out of reach. The present findings have implications for a key educational challenge: ensuring that students have continuing access to information they have learned.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mascle, J.; Blarez, E.

The authors present a marine study of the eastern Ivory Coast-Ghana continental margins which they consider one of the most spectacular extinct transform margins. This margin has been created during Early-Lower Cretaceous time and has not been submitted to any major geodynamic reactivation since its fabric. Based on this example, they propose to consider during the evolution of the transform margin four main and successive stages. Shearing contact is first active between two probably thick continental crusts and then between progressively thinning continental crusts. This leads to the creation of specific geological structures such as pull-apart graben, elongated fault lineaments,more » major fault scarps, shear folds, and marginal ridges. After the final continental breakup, a hot center (the mid-oceanic ridge axis) is progressively drifting along the newly created margin. The contact between two lithospheres of different nature should necessarily induce, by thermal exchanges, vertical crustal readjustments. Finally, the transform margin remains directly adjacent to a hot but cooling oceanic lithosphere; its subsidence behavior should then progressively be comparable to the thermal subsidence of classic rifted margins.« less

The feasibility and advantages of billroth-I reconstruction in distal gastric cancers following resection.

PubMed

Ganesh, M S; Reddy, K G; Venkata Subbareddy, D S

2012-01-01

Gastric carcinomas are common malignancies in southern India and distal stomach remains the commonest site in low socio economic groups. Surgery still remains an important modality of treatment to achieve local control and also relieve obstructive symptoms. In this study we investigated the feasibility of performing a gastrectomy and billroth-1 type of anastomosis in a rural cancer center setting, with parameters like adequacy of margins, ease of anastomosis and its functional results were analysed. Eight patients presenting to a rurally based cancer center underwent a distal gastrectomy and billroth-1 type of anastomosis for continuity restoration. All the patients had adequate proximal and distal marg. The surgical time varied between-hrs. The anastomosis was constructed without any tension on bowel ends in all patients. The average time to start oral feeds varied between- None of the patients showed symptoms of bile reflux nor dumping. The average hospital stay varied between. Billroth-1 anastomosis is a physiologically more natural way of restoring continuity following a gastrectomy and it is a procedure which would be technically more simpler and decrease per and post operative complications and allow speedier post operative recovery following surgery on distal gastric cancers.

[The economic margins of activities of a bovine practitioner on dairy farms].

PubMed

van Genugten, A J M; van Haaften, J A; Hogeveen, H

2011-11-01

Because of lower margins and market liberalisation veterinarians and farmers are increasingly negotiating rates. Therefore, the margins of veterinarians are under pressure. In addition, the sales if drugs, performance of operations or giving of advice are more and more separated. These developments give veterinarians uncertainty about the profitability of their activities for dairy farmers. Not much is known about margins on veterinary activities on dairy farms. Moreover, it is interesting to see how much margins of the bovine practitioner differ between veterinary practises and dairy farms. In this study, invoices for bovine activities of 14 veterinary practises were combined with milk production registration data of the dairy farms of these practices. This way, the gross margin per bovine practitioner could be studied for the different veterinary practise. Moreover the relation between gross margin and specification of the veterinary practise could be studied. Finally, the gross margin per dairy farm and the factors that influenced this gross margin were studied. The most important result was the observation that the gross margin per bovine practitioner was dependent on the number of dairy farms per practitioner, the margin on drugs and the region of the veterinary practise. The size of the veterinary practise, the share of the dairy farming within the practise and the source of the gross margin (drugs, time or operations) did not influence the gross margin. Variables that explained the gross margin per dairy farm were, amongst others, the number of dairy cows, the milk production level of the farms and participation in PIR-DAP (a system to support the veterinarians herd health and management program). There is no relation of gross margin per dairy farm and the veterinary practise or region.

Deglaciation of Fennoscandia

NASA Astrophysics Data System (ADS)

Stroeven, Arjen P.; Hättestrand, Clas; Kleman, Johan; Heyman, Jakob; Fabel, Derek; Fredin, Ola; Goodfellow, Bradley W.; Harbor, Jonathan M.; Jansen, John D.; Olsen, Lars; Caffee, Marc W.; Fink, David; Lundqvist, Jan; Rosqvist, Gunhild C.; Strömberg, Bo; Jansson, Krister N.

2016-09-01

To provide a new reconstruction of the deglaciation of the Fennoscandian Ice Sheet, in the form of calendar-year time-slices, which are particularly useful for ice sheet modelling, we have compiled and synthesized published geomorphological data for eskers, ice-marginal formations, lineations, marginal meltwater channels, striae, ice-dammed lakes, and geochronological data from radiocarbon, varve, optically-stimulated luminescence, and cosmogenic nuclide dating. This is summarized as a deglaciation map of the Fennoscandian Ice Sheet with isochrons marking every 1000 years between 22 and 13 cal kyr BP and every hundred years between 11.6 and final ice decay after 9.7 cal kyr BP. Deglaciation patterns vary across the Fennoscandian Ice Sheet domain, reflecting differences in climatic and geomorphic settings as well as ice sheet basal thermal conditions and terrestrial versus marine margins. For example, the ice sheet margin in the high-precipitation coastal setting of the western sector responded sensitively to climatic variations leaving a detailed record of prominent moraines and other ice-marginal deposits in many fjords and coastal valleys. Retreat rates across the southern sector differed between slow retreat of the terrestrial margin in western and southern Sweden and rapid retreat of the calving ice margin in the Baltic Basin. Our reconstruction is consistent with much of the published research. However, the synthesis of a large amount of existing and new data support refined reconstructions in some areas. For example, the LGM extent of the ice sheet in northwestern Russia was located far east and it occurred at a later time than the rest of the ice sheet, at around 17-15 cal kyr BP. We also propose a slightly different chronology of moraine formation over southern Sweden based on improved correlations of moraine segments using new LiDAR data and tying the timing of moraine formation to Greenland ice core cold stages. Retreat rates vary by as much as an order of magnitude in different sectors of the ice sheet, with the lowest rates on the high-elevation and maritime Norwegian margin. Retreat rates compared to the climatic information provided by the Greenland ice core record show a general correspondence between retreat rate and climatic forcing, although a close match between retreat rate and climate is unlikely because of other controls, such as topography and marine versus terrestrial margins. Overall, the time slice reconstructions of Fennoscandian Ice Sheet deglaciation from 22 to 9.7 cal kyr BP provide an important dataset for understanding the contexts that underpin spatial and temporal patterns in retreat of the Fennoscandian Ice Sheet, and are an important resource for testing and refining ice sheet models.

Synchronous onset of the Messinian evaporite precipitation: First Mediterranean offshore evidence

NASA Astrophysics Data System (ADS)

Ochoa, Diana; Sierro, Francisco J.; Lofi, Johanna; Maillard, Agnès; Flores, Jose-Abel; Suárez, Mercedes

2015-10-01

The Messinian Salinity Crisis (MSC) was a major ecological crisis affecting shallow and deep-water settings over the entire Mediterranean basin. However, the evolution of the MSC and its ecological impacts have mainly been explained on the basis of sediments from onshore outcrops. Lack of complete and physically connected records from onshore and offshore settings has inhibited comprehensive understanding of basin behaviour during the MSC. Herein we present a continuous record from an intermediate-depth basin on the Balearic Promontory that comprises late Tortonian-Messinian marls and evaporitic beds from the first MSC phase (i.e., Primary Lower Gypsum-PLG stage). Well-log and biostratigraphic data allow us establishing a large-scale calibration to the astronomical solutions, and to correlate pre-MSC sediments with classical rhythmic successions outcropping onshore. Thickness and characteristic sedimentary patterns observed in the offshore evaporitic records resemble those from marginal PLG sequences. Furthermore, seismic reflectors from a Bedded Unit (BU), which corresponds to an evaporitic interval according to well-to-seismic ties, are correlated with the onshore PLG sequences. This correlation constitutes the first attempt to link well-known marginal sequences with intermediate-depth offshore settings, which have previously only been studied through seismic imaging. Our time-calibration provides direct evidence supporting a synchronous onset of the PLG phase between onshore and offshore settings along the southwestern Balearic Promontory margin. Those BU reflectors, which were positively correlated to the PLG, were likely precipitated offshore the continental shelf at Messinian times. These results suggest that gypsum precipitation and/or preservation was not always limited to 200 m water-depths and could occur in non-silled basins. Finally, we only found a major erosion at the top of the PLG sequences, implying that the MSC drawdown occurred after the precipitation of the onshore lower evaporites. Studied sequences provide new insights into the PLG precipitation/preservation settings, as well as into the land-sea correlations of MSC units, and thus could potentially help refine current MSC models.

One Dimensional Backstripping Results from IODP Expedition 318, Site U1356: Tectonic Implications for the Wilkes Land Margin of Antarctica

NASA Astrophysics Data System (ADS)

Hayden, T. G.; Kominz, M. A.; González, J. J.; Escutia, C.; Brinkhuis, H.; Scientific Party of IODP Expedition 318

2011-12-01

The Wilkes Land margin of Antarctica is the conjugate margin of the Great Australian Bight, which underwent extension, thinning and rifting from ~160 Ma until breakup at ~83 Ma. Both Wilkes Land and the Great Australian Bight are considered passive margins, and were thought to be tectonically inactive since breakup at 83 Ma. We have backstripped the U1356 Core recovered from the continental rise off Wilkes Land, Antarctica by IODP Expedition 318. Backstripping input included lithological and sedimentary analysis, paleo-environmental indicators, combined paleomagnetic and biostratigraphic chronologies, and physical properties measurements. Tectonic subsidence shows a major event between 50 and 33.6 Ma, a time represented by a hiatus in the U1356 core. The magnitude of subsidence requires it to be tectonic in origin, and the timing matches with a reorganization of plate motions that represents the transition from slow spreading to fast spreading between Antarctica and Australia, which occurred at approximately 43 Ma. Coupled with a regional seismic framework, and using other Expedition 318 site analyses, the Wilkes Land margin is shown to be far more complex then the simple passive margin currently assumed. We explore several possible mechanisms for the subsidence and erosion observed; including thermal uplift due to continental insulation of the asthenosphere and it's interaction with a recently rifted margin, asthenospheric convection, transtensional or transpressional basin development and loading, and edge-driven asthenospheric convection.

Economic value of big game habitat production from natural and prescribed fire

Treesearch

Armando Gonzalez-Caban; John B. Loomis; Dana Griffin; Elen Wu; Daniel McCollum; Jane McKeever; Diane Freeman

2003-01-01

A macro time-series model and a micro GIS model were used to estimate a production function relating deer harvest response to prescribed fire, holding constant other environmental variables. The macro time-series model showed a marginal increase in deer harvested of 33 for an increase of 1,100 acres of prescribed burn. The marginal deer increase for the micro GIS model...

Present-day crustal motion around eastern margin of the Pamir plateau from GPS measurements

NASA Astrophysics Data System (ADS)

Pan, Z.; He, J.; Zhou, Y.; Wang, W.

2017-12-01

The Pamir plateau is featured mainly by northward convex thrust faults in its center and by strike-slip faults on its western and eastern sides. To better describe the deformation pattern of the Pamir plateau, a new campaign-mode GPS network has been deployed with 18 stations around the boundary between the Pamir and the Tarim since 2012. The network has been surveyed 3 times, and each site has been surveyed for at least 48 hours with Trimble NetR8 receivers and zephyr geodetic antennas. By combining the nearest Continuous GPS sites (GUAO KIT3 POL2 CHUM URUM ARTU BJFS IISC IRKT LHAZ SHAO ULAB WUHN YIBL), we then processed the observing data with GAMIT/GLOBK software to obtain the velocity field of the network. Results show that, unlike the western margin of the Pamir plateau where significant ( 9mm/yr) left-lateral motion between the Tajik basin and the Pamir was observed, the eastern margin between the Pamir and the Tarim exists negligible strike-slip motion along the boundary. However, perpendicular to the Pamir-Tarim boundary, we observed clearly coeval extension and compression strain across this boundary. By calibrating the strain distribution and the simplified structure profiles, it can be seen that the extension rate locates mainly around the Tashkurghan basin; while the compression strain around the Tashkurghan basin and the Tarim basin. We also predicted that among the total strain rate, the extension rate is about 4-6mm/yr and the compression rate about 2-3mm/yr. This suggests that the general tectonic stress across the eastern margin of the Pamir plateau is extension, in agreement with previous result of anti-clockwise rotation of the Pamir. Finally, the possible mechanics on co-existence of extension and compression along same direction has been discussed by building a two-dimensional viscoelastic finite model.

Late Weichselian ice-sheet dynamics and deglaciation history of the northern Svalbard margin

NASA Astrophysics Data System (ADS)

Fransner, O.; Noormets, R. R. N. N.; Flink, A.; Hogan, K.; Dowdeswell, J. A.; O'Regan, M.; Jakobsson, M.

2016-12-01

The glacial evolution of the northern Svalbard margin is poorly known compared with the western margin. Gravity cores, swath bathymetric, sub-bottom acoustic and 2D airgun data are used to investigate the Late Weichselian Svalbard-Barents Ice Sheet history on the northern Svalbard margin. Prograding sequences in Kvitøya and Albertini trough mouths (TMs) indicate ice streaming to the shelf edge multiple times during the Quaternary. While Kvitøya Trough has an associated trough-mouth fan (TMF), Albertini TM is cut back into the shelf edge. Down-faulted bedrock below Albertini TM suggests larger sediment accommodation space there, explaining the absence of a TMF. The bathymetry indicates that ice flow in Albertini Trough was sourced from Duvefjorden and Albertinibukta. Exposed crystalline bedrock likely kept the two ice flows separated before merging north of Karl XII-Øya. Subglacial landforms in Rijpfjorden and Duvefjorden indicate that both fjords accommodated northward-flowing ice streams during the LGM. The deeper fjord basin and higher elongation ratios of landforms in Duvefjorden suggest a more focused and/or larger ice flow there. Easily erodible sedimentary rocks are common in Duvefjorden, which may explain different ice flow dynamics in these fjords. Kvitøya TMF is flanked by gullies, probably formed through erosive downslope gravity flows triggered by sediment-laden meltwater during early deglaciation. Glacial landforms in Albertini Trough comprise retreat-related landforms indicating slow deglaciation. Iceberg scours in Albertini Trough suggest the importance of calving for mass-loss. Sets of De Geer moraines in Rijpfjorden imply that slow, grounded retreat continued in <210 m water depth. Lack of retreat-related landforms in deeper areas of Rijpfjorden and in Duvefjorden indicates floating glacier fronts influenced by calving. 14C ages suggest that deglaciation of inner Rijpfjorden and central Duvefjorden were complete before 10,434 cal a BP and 10,779 cal a BP respectively.

Trace fossil analysis of lacustrine facies and basins

USGS Publications Warehouse

Buatois, L.A.; Mangano, M.G.

1998-01-01

Two ichnofacies are typical of lacustrine depositional systems. The Scoyenia ichnofacies characterizes transitional terrestrial/nonmarine aquatic substrates, periodically inundated or desiccated, and therefore is commonly present in lake margin facies. The Mermia ichnofacies is associated with well oxygenated, permanent subaqueous, fine-grained substrates of hydrologically open, perennial lakes. Bathymetric zonations within the Mermia ichnofacies are complicated by the wide variability of lacustrine systems. Detected proximal-distal trends are useful within particular lake basins, but commonly difficult to extrapolate to other lakes. Other potential ichnofacies include the typically marine Skolithos ichnofacies for high-energy zones of lakes and substrate-controlled, still unnamed ichnofacies, associated to lake margin deposits. Trace fossils are useful for sedimentologic analysis of event beds. Lacustrine turbidites are characterized by low-diversity suites, reflecting colonization by opportunistic organisms after the turbidite event. Underflow current beds record animal activity contemporaneous with nearly continuous sedimentation. Ichnologic studies may also help to distinguish between marine and lacustrine turbidites. Deep-marine turbidites host the Nereites ichnofacies that consists of high diversity of ornate grazing traces and graphoglyptids, recording highly specialized feeding strategies developed to solve the problem of the scarcity of food in the deep sea. Deep lacustrine environments contain the Mermia ichnofacies, which is dominated by unspecialized grazing and feeding traces probably related to the abundance and accessibility of food in lacustrine systems. The lower diversity of lacustrine ichnofaunas in comparison with deep-sea assemblages more likely reflects lower species diversity as a consequence of less stable conditions. Increase of depth and extent of bioturbation through geologic time produced a clear signature in the ichnofabric record of lacustrine facies. Paleozoic lacustrine ichnofaunas are typically dominated by surface trails with little associated bioturbation. During the Mesozoic, bioturbation depth was higher in lake margin facies than in fully lacustrine deposits. While significant degrees of bioturbation were attained in lake margin facies during the Triassic, major biogenic disruption of primary bedding in subaqueous lacustrine deposits did not occur until the Cretaceous.

Paleozoic tectonics in the eastern part of Central Asian Orogenic Belt

NASA Astrophysics Data System (ADS)

Liu, Yongjiang; Li, Weimin; Feng, Zhiqiang; Neubauer, Franz

2017-04-01

The Central Asian Orogenic Belt (CAOB) is the largest accretionary orogen in the world, which is responsible for considerable Phanerozoic juvenile crustal growth. The NE China and its adjacent areas compose the eastern segment of the CAOB, which is a key area for providing important evidence of the CAOB evolution and understanding the NE Asian tectonics. The eastern segment of the CAOB is composed tectonically of four micro-blocks and four sutures, i.e. Erguna block (EB), Xing'an block (XB), Songliao-Xilinhot block (SXB), Jiamusi block (JB), Xinlin-Xiguitu suture (XXS), Heihe-Hegenshan suture (HHS), Mudanjiang-Yilan suture (MYS) and Solonker-Xar Moron-Changchun-Yanji suture (SXCYS). The EB and XB were amalgamated by westward subduction, oceanic island accretions and final collision in ca. 500 Ma. The XB and SXB were amalgamated by subduction-related Early Paleozoic marginal arc, Late Paleozoic marginal arc and final collision in the late Early Carboniferous to early Late Carboniferous. The JB probably had been attached to the SXB in the Early Paleozoic, but broken apart from the SXB in the Triassic and collided back in the Jurassic. The closure of Paleo-Asian Ocean had experienced a long continue/episodic subduction-accretion processes on margins of the NCC to the south and the SXB to the north from the Early to Late Paleozoic. The final closure happened along the SXCYS, from west Solonker, Sonid Youqi, Kedanshan (Keshenketengqi), Xar Moron River through Songliao Basin via Kailu, Tongliao, Horqin Zuoyizhongqi, Changchun, to the east Panshi, Huadian, Dunhua, Yanji, with a scissors style closure in time from the Late Permian-Early Triassic in the west to the Late Permian-Middle Triassic in the east. The amalgamated blocks should compose a united micro-continent, named as Jiamusi-Mongolia Block (JMB) after Early Carboniferous, which bounded by Mongo-Okhotsk suture to the northwest, Solonker-Xar Moron-Changchun suture to the south and the eastern margin of JB to the east.

Chukchi Borderland | Crustal Complex of the Amerasia Basin, Arctic Ocean

NASA Astrophysics Data System (ADS)

Ilhan, I.; Coakley, B.; Houseknecht, D. W.

2017-12-01

In the Arctic Ocean, Chukchi Borderland separates the North Chukchi shelf and Toll deep basins to the west and Canada deep basin to the east. Existing plate reconstructions have attempted to restore this north-striking, fragments of the continental crust to all margins of the Amerasia Basin based on sparse geologic and geophysical measurements. Regional multi-channel seismic reflection and potential field geophysics, and geologic data indicate it is a high standing continental block, requiring special accommodation to create a restorable model of the formation of the Amerasia Basin. The Borderland is composed of the Chukchi Plateau, Northwind Basin, and Northwind Ridge divided by mostly north striking normal faults. These offset the basement and bound a sequence of syn-tectonic sediments. Equivalent strata are, locally, uplifted, deformed and eroded. Seaward dipping reflectors (SDRs) are observed in the juncture between the North Chukchi, Toll basins, and southern Chukchi Plateau underlying a regional angular unconformity. This reveals that this rifted margin was associated with volcanism. An inferred condensed section, which is believed to be Hauterivian-Aptian in age, synchronous with the composite pebble shale and gamma-ray zone of the Alaska North Slope forms the basal sediments in the North Chukchi Basin. Approximately 15 km of post-rift strata onlap the condensed section, SDRs and, in part, the wedge sequence on the Chukchi Plateau from west to east, thinning to the north. These post-Aptian sediments imply that the rifted margin subsided no later than the earliest Cretaceous, providing a plausible time constraint for the inferred pre-Cretaceous rifting in this region. The recognition of SDRs and Hauterivian—Aptian condensed section, and continuity of the Early—Late Cretaceous post-rift strata along the margins of the Borderland, strike variations of the normal faults, absence of observable deformation along the Northwind Escarpment substantially constrain tectonic models proposed for tectonic development of the Amerasia Basin. Models that require significant relative motion between the Chukchi Shelf and Borderland since the Early Cretaceous are precluded by these observations.

The Effects of Rapid Sedimentation upon Continental Breakup: Kinematic and Thermal Modeling of the Salton Trough, Southern California, Based upon Recent Seismic Images

NASA Astrophysics Data System (ADS)

Han, L.; Hole, J. A.; Lowell, R. P.; Stock, J. M.; Fuis, G. S.

2016-12-01

The Salton Seismic Imaging Project (SSIP) illuminated crustal and upper mantle structure of the Salton Trough, the northern-most rift segment of the Gulf of California plate boundary. The crust is 17-18 km thick and homogeneous for 100 km in the plate motion direction. New crust is being created by distributed rift magmatism, Colorado River sedimentation, and metamorphism of the sediment. A 5 km thick pre-existing crustal layer may still exist. The crust has not broken apart to enable initiation of seafloor spreading. A one-dimensional time-dependent kinematic and thermal model was developed to simulate these observations. We assume that all crustal layers are stretched uniformly during extension. Distributed mafic magmatism and sedimentation are added simultaneously to compensate for the crustal thinning. The ratio of magmatism to sedimentation is constrained by the seismic observations. Heat is transported by thermal conduction and by advection due to stretching of the crust. A constant temperature boundary at the Moho is used to represent partial melting in the upper mantle. Assuming a constant plate motion rate, the zone of active rifting extends linearly with time. The crustal thickness and internal structure also evolve with time. The model constraints are the observed seismic structure and heat flow. The model rapidly reaches quasi-steady state, and could continue for many millions of years. The observed seismic structure and heat flow are reproduced after 3 Myr. The yield strength profile calculated from lithology and model temperature indicates that ductile deformation in the middle and lower crust dominates the crustal rheology. Rapid sedimentation delays crustal breakup and the initiation of seafloor spreading by maintaining the thickness of the crust and keeping it predominantly ductile. This process probably occurs wherever a large river flows into an active rift driven by far-field extension. It may have built passive margins in many locations globally, such as the Gulf of Mexico. This type of passive margin consists of mostly new crust created by magmatism and metamorphism of sediment. Along such margins, metamorphosed sediment could be misinterpreted as stretched pre-existing continental crust.

Investments in energy technological change under uncertainty

NASA Astrophysics Data System (ADS)

Shittu, Ekundayo

2009-12-01

This dissertation addresses the crucial problem of how environmental policy uncertainty influences investments in energy technological change. The rising level of carbon emissions due to increasing global energy consumption calls for policy shift. In order to stem the negative consequences on the climate, policymakers are concerned with carving an optimal regulation that will encourage technology investments. However, decision makers are facing uncertainties surrounding future environmental policy. The first part considers the treatment of technological change in theoretical models. This part has two purposes: (1) to show--through illustrative examples--that technological change can lead to quite different, and surprising, impacts on the marginal costs of pollution abatement. We demonstrate an intriguing and uncommon result that technological change can increase the marginal costs of pollution abatement over some range of abatement; (2) to show the impact, on policy, of this uncommon observation. We find that under the assumption of technical change that can increase the marginal cost of pollution abatement over some range, the ranking of policy instruments is affected. The second part builds on the first by considering the impact of uncertainty in the carbon tax on investments in a portfolio of technologies. We determine the response of energy R&D investments as the carbon tax increases both in terms of overall and technology-specific investments. We determine the impact of risk in the carbon tax on the portfolio. We find that the response of the optimal investment in a portfolio of technologies to an increasing carbon tax depends on the relative costs of the programs and the elasticity of substitution between fossil and non-fossil energy inputs. In the third part, we zoom-in on the portfolio model above to consider how uncertainty in the magnitude and timing of a carbon tax influences investments. Under a two-stage continuous-time optimal control model, we consider the impact of these uncertainties on R&D spending that aims to lower the cost of non-fossil energy technology. We find that our results tally with the classical results because it discourages near-term investment. However, timing uncertainty increases near-term investment.

Mesozoic to Recent, regional tectonic controls on subsidence patterns in the Gulf of Mexico basin

NASA Astrophysics Data System (ADS)

Almatrood, M.; Mann, P.; Bugti, M. N.

2016-12-01

We have produced subsidence plots for 26 deep wells into the deeper-water areas of the Gulf of Mexico (GOM) in order to identify regional tectonic controls and propose tectonic phases. Our results show three sub-regions of the GOM basin that have distinctive and correlative subsidence patterns: 1) Northern GOM from offshore Texas to central Florida (9 wells) - this area is characterized by a deeply buried, Triassic-early Jurassic rift event that is not represented by our wells that penetrate only the post-rift Cretaceous to recent passive margin phase. The sole complexity in the passive margin phase of this sub-region is the acceleration of prograding clastic margins including the Mississippi fan in Miocene time; 2) Southeastern GOM in the Straits of Florida and Cuba area (5 wells) - this area shows that the Cretaceous passive margin overlying the rift phase is abruptly drowned in late Cretaceous as this part of the passive margin of North America that is flexed and partially subducted beneath the Caribbean arc as it encroaches from the southwest to eventually collide with the North American passive margin in the Paleogene; 3) Western GOM along the length of the eastern continental margin of Mexico (12 wells) - this is the most complex of the three areas in that shares the Mesozic rifting and passive margin phase but is unique with a slightly younger collisional event and foreland basin phase associated with the Laramide orogeny in Mexico extending from the KT boundary to the Oligocene. Following this orogenic event there is a re-emergence of the passive margin phase during the Neogene along locally affected by extensional and convergent deformation associated with passive margin fold belts. In summary, the GOM basin exhibits evidence for widespread rifting and passive margin formation associated with the breakup of Pangea in Mesozoic times that was locally superimposed and deformed during the late Cretaceous-Paleogene period by: 1) Caribbean subduction and collision along its southeastern edge; and 2) Laramide collision along its western edge in Mexico.

Nano-optomechanical characterization of surface-plasmon-based tunable filter integrated with comb-drive actuator

NASA Astrophysics Data System (ADS)

Honma, H.; Mitsudome, M.; Ishida, M.; Sawada, K.; Takahashi, K.

2017-03-01

We report a tunable plasmonic color filter consisting of a metamaterial periodic grating and microelectromechanical systems (MEMS) actuator. An aluminum subwavelength grating is integrated with electrostatic comb-drive actuators to expand the metal subwavelength period, which allows continuous control of the excitation wavelength of surface plasmons (SPs). We develop a batch fabrication process by employing a liftoff technique using an electron beam resist altered by the electron dose depending on different aspect ratios (length/width) for various components such as the subwavelength grating, nanohinge flexural suspensions, and comb fingers. We successfully demonstrate a continuous shift in the excitation wavelength over the 514-635 nm range by nanopitch expansion. The design margin of the grating period for SP excitation is evaluated by comparing the experimental pitch variation and theoretically calculated values. The resonance frequency of the tunable filter is optically measured to be approximately 10 kHz. The optically and mechanically obtained values agree well with the theory of electrostatic actuation and finite-difference time-domain simulation.

The Variability in Surgical Margin Reporting in Limb Salvage Surgery for Sarcoma

PubMed Central

Hoang, Kevin; Gao, Yubo; Miller, Benjamin J.

2015-01-01

Background Surgical margins are a standard reported measurement in tumor surgery that has implications for functional outcome, local control, and overall survival. There is no single accepted classification, and it is unclear what form or margin reporting predominates in the sarcoma literature. Methods We performed a PubMed literature search to identify articles that reported surgical margins and oncologic outcomes in limb salvage surgery for sarcoma from 1980 to 2013. We recorded the margin classification, specialty of the journal, specialty of the author, and location of the authors' institution. Results We found that 159/448 (35%) of articles included in the study did not report surgical margins. Of the 289 papers that did include data on margins, 160 (55%) of articles used Enneking's classification. There has been an increase over time in the proportion of articles reporting surgical margins by the residual tumor (R) classification and the proportion of articles reporting margins dichotomously as “positive” or “negative.” Conclusions We did not find a common method for reporting margins in the limb salvage sarcoma literature. Of most concern was over 1/3 of clinical reports of oncologic outcomes did not include margin status, which substantially compromises any conclusions that readers may infer about treatment success, local recurrence, or survival. We believe there should be renewed efforts to encourage use of a common surgical margin reporting system that is simple, reproducible, and prognostic. PMID:26361463

Carbonate mound development in contrasting settings on the Irish margin

NASA Astrophysics Data System (ADS)

van der Land, Cees; Eisele, Markus; Mienis, Furu; de Haas, Henk; Hebbeln, Dierk; Reijmer, John J. G.; van Weering, Tjeerd C. E.

2014-01-01

Cold-water coral carbonate mounds, formed by framework building cold-water corals, are found in several mound provinces on the Irish margin. Differences in cold-water coral mound development rates and sediment composition between mounds at the southwest Rockall Trough margin and the Galway Mound in the Porcupine Seabight are investigated. Variations in sediment composition in the two mound provinces are related to the local environmental conditions and sediment sources. Mound accumulation rates are possibly higher at the Galway Mound probably due to a higher influx of hemipelagic fine grained non-carbonate sediments. In both cold-water coral mound areas, mound growth has been continuous for the last ca 11,000 years, before this period several hiatuses and unconformities exist in the mound record. The most recent unconformity can be correlated across multiple mounds and mound provinces at the Irish margin on the basis of apparent age. On the southwest Rockall Trough margin these hiatuses/unconformities are associated with post-depositional aragonite dissolution in, and lithification of, certain intervals, while at Galway Mound no lithification occurs. This study revealed that the influx and types of material transported to cold-water coral mounds may have a direct impact on the carbonate mound accumulation rate and on post-depositional processes. Significantly, the Logachev Mounds on the SW Rockall Trough margin accumulate slower but, because they contain lithified layers, are less susceptible to erosion. This net effect may account for their larger size compared to the Belgica Mounds.

Structure and evolution of the NE Atlantic conjugate margins off Norway and Greenland (Invited)

NASA Astrophysics Data System (ADS)

Faleide, J.; Planke, S.; Theissen-Krah, S.; Abdelmalak, M.; Zastrozhnov, D.; Tsikalas, F.; Breivik, A. J.; Torsvik, T. H.; Gaina, C.; Schmid, D. W.; Myklebust, R.; Mjelde, R.

2013-12-01

The continental margins off Norway and NE Greenland evolved in response to the Cenozoic opening of the NE Atlantic. The margins exhibit a distinct along-margin segmentation reflecting structural inheritance extending back to a complex pre-breakup geological history. The sedimentary basins at the conjugate margins developed as a result of multiple phases of post-Caledonian rifting from Late Paleozoic time to final NE Atlantic breakup at the Paleocene-Eocene transition. The >200 million years of repeated extension caused comprehensive crustal thinning and formation of deep sedimentary basins. The main rift phases span the following time intervals: Late Permian, late Middle Jurassic-earliest Cretaceous, Early-mid Cretaceous and Late Cretaceous-Paleocene. The late Mesozoic-early Cenozoic rifting was related to the northward propagation of North Atlantic sea floor spreading, but also linked to important tectonic events in the Arctic. The pre-drift extension is quantified based on observed geometries of crustal thinning and stretching factors derived from tectonic modeling. The total (cumulative) pre-drift extension amounts to in the order of 300 km which correlates well with estimates from plate reconstructions based on paleomagnetic data. Final lithospheric breakup at the Paleocene-Eocene transition culminated in a 3-6 m.y. period of massive magmatic activity during breakup and onset of early sea-floor spreading, forming a part of the North Atlantic Volcanic Province. At the outer parts of the conjugate margins, the lavas form characteristic seaward dipping reflector sequences and lava deltas that drilling has demonstrated to be subaerially and/or neritically erupted basalts. The continent-ocean transition is usually well defined as a rapid increase of P-wave velocities at mid- to lower-crustal levels. Maximum igneous crustal thickness of about 18 km is found across the outer Vøring Plateau on the Norwegian Margin, and lower-crustal P-wave velocities of up to 7.3 km/s are found at the bottom of the igneous crust here. The igneous crust, including the characteristic 7+ km/s lower crustal body, is even thicker on the East Greenland Margin. During the main igneous episode, sills intruded into the thick Cretaceous successions throughout the NE Atlantic margins. Strong crustal reflections can be mapped widespread on both conjugate margins. In some areas they are associated with the top of the high-velocity lower crustal body, in other areas they may represent deeply buried sedimentary sequence boundaries or moho at the base of the crust. Following breakup, the subsiding margins experienced modest sedimentation until the late Pliocene when large wedges of glacial sediments prograded into the deep ocean from uplifted areas along the continental margins. The outbuilding was probably initiated in Miocene time indicating pre-glacial tectonic uplift of Greenland, Fennoscandia and the Barents Shelf. The NE Atlantic margins also reveal evidence of widespread Cenozoic compressional deformation.

Paleomagnetic constraints on the interpretation of early Cenozoic Pacific Northwest paleogeography

USGS Publications Warehouse

Wells, Ray E.

1984-01-01

Widespread Cenozoic clockwise tectonic rotation in the Pacific Northwest is an established fact; however, the geologic reconstructions based on these rotations are the subject of continuing debate. Three basic mechanisms have been proposed to explain the rotations: (1) simple shear rotation of marginal terranes caught in the dextral shear couple between oceanic plates and North America; (2) rotation during oblique microplate collision and accretion to the continental margin; and (3) rotation of continental margin areas during episodes of intracontinental extension. In areas where detailed structure and stratigraphy are available, distributed shear rotations are amplv demonstrated paleomagnetically. However, rotation due to asymmetric interarc extension must be significant, especially for the Oregon Coast Range, in light of recent estimates of large Tertiary extension across the northern Basin and Range. The relative importance of shear versus extension is difficult to determine, but shear could account for nearly onehalf of the observed rotations. Oblique microplate collision has not contributed significantly to the observed Cenozoic rotations because most of the rotation post-dates collision-related deformation in the Oregon and Washington. Coast Range. The resultant continental reconstructions suggest that about 300 km of extension has occurred at 42°N. latitude (southern Oregon border) since early Eocene time. This reconstruction suggests that Cretaceous sedimentary basins east of the Klamath Mountains have undergone significant Tertiary extension (about f<0%) , but little rotation. Upper Cretaceous sedimentary rocks in the Blue Mountains of Oregon near Mitchell are probably rotated at least 15° and perhaps as much as 60°, which allows considerable latitude in the restoration of that part of the basin.

The West Philippine Basin: An Eocene to early Oligocene back arc basin opened between two opposed subduction zones

NASA Astrophysics Data System (ADS)

Deschamps, Anne; Lallemand, Serge

2002-12-01

Based on geological and geophysical data collected from the West Philippine Basin and its boundaries, we propose a comprehensive Cenozoic history of the basin. Our model shows that it is a back arc basin that developed between two opposed subduction zones. Rifting started around 55 Ma and spreading ended at 33/30 Ma. The initial spreading axis was parallel to the paleo-Philippine Arc but became inactive when a new spreading ridge propagated from the eastern part of the basin, reaching the former one at an R-R-R triple junction. Spreading occurred mainly from this second axis, with a quasi-continuous counter-clockwise rotation of the spreading direction. The Gagua and Palau-Kyushu ridges acted as transform margins accommodating the opening. Arc volcanism occurred along the Palau-Kyushu Ridge (eastern margin) during the whole opening of the basin, whereas the paleo-Philippine Arc decreased its activity between 43 and 36 Ma. The western margin underwent a compressive event in late Eocene-early Oligocene time, leading to the rising of the Gagua Ridge and to a short subduction episode along Eastern Luzon. In the western part of the basin, the spreading system was highly disorganized due to the presence of a mantle plume. Overlapping spreading centers and ridge jumps occurred toward the hot region and a microplate developed. Shortly after the end of the spreading, a late stage of amagmatic extension occurred between 30 and 26 Ma in the central part of the basin, being responsible for the deep rift valley that cut across the older spreading fabric.

Tethys- and Atlas-related deformations in the Triassic Basin, Algeria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, J.S.; Moore, S.R.; Quarles, A.I.

1995-08-01

Petroleum provinces of Algeria can be divided into Paleozoic and Mesozoic domains. Paleozoic basins are located on the Gondwanaland paleo-continent where the last significant tectonic episode is ascribed to the Late Paleozoic Hercynian Orogeny. Mesozoic basins are located on the south margin of the Neo-Tethyan seaway. These basins were subject to varying degrees of contractional deformation during the Cenozoic Atlas Orogeny. The Triassic Basin of Algeria is a Tethyan feature located above portions of the Paleozoic Oued M`ya and Ghadames Basins. Paleozoic strata are deeply truncated at the Hercynian Unconformity on a broad arch between the older basins. This ismore » interpreted to reflect rift margin rebound during Carboniferous time. Continental Lower Triassic sediments were deposited in a series of northeast trending basins which opened as the Neo-Tethys basin propagated from east to west between Africa and Europe. Middle Triassic marine transgression from the east resulted in evaporate deposition persisting through the Early Jurassic. Passive margin subsidence associated with carbonate marine deposition continued through the Early Cretaceous. Several zones of coeval wrench deformation cross the Atlas and adjoining regions. In the Triassic Basin, inversion occurred before the end of the Early Cretaceous. This episode created discrete uplifts, where major hydrocarbon accumulations have been discovered, along northeast trending lineaments. During the Eocene, the main phase of the Atlas Orogeny produced low amplitude folding of Jurassic and Cretaceous sediments. The folds detach within the Triassic-Jurassic evaporate interval. Many of these folds have been tested without success, as the deeper reservoirs do not show structural closure.« less

Modeling ocean wave propagation under sea ice covers

NASA Astrophysics Data System (ADS)

Zhao, Xin; Shen, Hayley H.; Cheng, Sukun

2015-02-01

Operational ocean wave models need to work globally, yet current ocean wave models can only treat ice-covered regions crudely. The purpose of this paper is to provide a brief overview of ice effects on wave propagation and different research methodology used in studying these effects. Based on its proximity to land or sea, sea ice can be classified as: landfast ice zone, shear zone, and the marginal ice zone. All ice covers attenuate wave energy. Only long swells can penetrate deep into an ice cover. Being closest to open water, wave propagation in the marginal ice zone is the most complex to model. The physical appearance of sea ice in the marginal ice zone varies. Grease ice, pancake ice, brash ice, floe aggregates, and continuous ice sheet may be found in this zone at different times and locations. These types of ice are formed under different thermal-mechanical forcing. There are three classic models that describe wave propagation through an idealized ice cover: mass loading, thin elastic plate, and viscous layer models. From physical arguments we may conjecture that mass loading model is suitable for disjoint aggregates of ice floes much smaller than the wavelength, thin elastic plate model is suitable for a continuous ice sheet, and the viscous layer model is suitable for grease ice. For different sea ice types we may need different wave ice interaction models. A recently proposed viscoelastic model is able to synthesize all three classic models into one. Under suitable limiting conditions it converges to the three previous models. The complete theoretical framework for evaluating wave propagation through various ice covers need to be implemented in the operational ocean wave models. In this review, we introduce the sea ice types, previous wave ice interaction models, wave attenuation mechanisms, the methods to calculate wave reflection and transmission between different ice covers, and the effect of ice floe breaking on shaping the sea ice morphology. Laboratory experiments, field measurements and numerical simulations supporting the fundamental research in wave-ice interaction models are discussed. We conclude with some outlook of future research needs in this field.

Nurture Versus Nature: Accounting for the Differences Between the Taiwan and Timor active arc-continent collisions

NASA Astrophysics Data System (ADS)

Harris, R. A.

2011-12-01

The active Banda arc/continent collision of the Timor region provides many important contrasts to what is observed in Taiwan, which is mostly a function of differences in the nature of the subducting plate. One of the most important differences is the thermal state of the respective continental margins: 30 Ma China passive margin versus 160 Ma NW Australian continental margin. The subduction of the cold and strong NW Australian passive margin beneath the Banda trench provides many new constraints for resolving longstanding issues about the formative stages of collision and accretion of continental crust. Some of these issues include evidence for slab rollback and subduction erosion, deep continental subduction, emplacement or demise of forearc basement, relative amounts of uplift from crustal vs. lithospheric processes, influence of inherited structure, partitioning of strain away from the thrust front, extent of mélange development, metamorphic conditions and exhumation mechanisms, continental contamination and accretion of volcanic arcs, does the slab tear, and does subduction polarity reverse? Most of these issues link to the profound control of lower plate crustal heterogeneity, thermal state and inherited structure. The thermomechanical characteristics of subducting an old continental margin allow for extensive underthrusting of lower plate cover units beneath the forearc and emplacement and uplift of extensive nappes of forearc basement. It also promotes subduction of continental crust to deep enough levels to experience high pressure metamorphism (not found in Taiwan) and extensive contamination of the volcanic arc. Seismic tomography confirms subduction of continental lithosphere beneath the Banda Arc to at least 400 km with no evidence for slab tear. Slab rollback during this process results in massive subduction erosion and extension of the upper plate. Other differences in the nature of the subducting plates in Taiwan in Timor are differences in the lateral continuity of the continental margins. The northern Australian continental margin is highly irregular with many rift basins subducting parallel to their axes. This feature gives rise to irregularities in the uplift pattern of the collision and its continental margin parallel structural grain. Another major difference between Taiwan and Timor is the mechanical stratigraphy entering the trench. The Australian continental margin bears a carbonate rich pre and post rift sequence that is separated by a 1000 m thick, over pressured mudstone unit that acts as major detachment and promotes extensive mud diapirism. The post breakup Australian Passive Margin Sequence is incorporated into the orogenic wedge by frontal accretion and forms a classic imbricate thrust stack near the front of the Banda forearc. The pre breakup Gondwana Sequence below the detachment continues at least to depth of 30 km in the subduction channel beneath the Banda forearc upper plate and stacks up into a duplex zone that forms structural culminations throughout Timor. The upper plate of both collisions is similar in nature but is deformed in different ways due to the strong influence of the lower plate. However, both have extensive subduction erosion and demise of the forearc and systematic accretion of the arc.

Using fluorescence lymphangiography to define the ileocolic mesentery: proof of concept for the watershed area using real-time imaging.

PubMed

Keller, D S; Joshi, H M; Rodriguez-Justo, M; Walsh, D; Coffey, J C; Chand, M

2017-09-01

Recent advances in mesenteric science have demonstrated that the mesentery is a continuous structure with a 'watershed' area at the mesenteric apex between the right colon and terminal ileum, where lymphatic flow can proceed either proximally or distally. With this new understanding of the anatomy, functional features are emerging, which can have an impact on surgical management. Fluorescence lymphangiography or lymphoscintigraphy with indocyanine green allows real-time visualization of lymphatic channels, which highlights sentinel lymph nodes and may facilitate identification of the ideal margins for mesenteric lymphadenectomy during bowel resection for colon cancer. By using this novel technology, it is possible to demonstrate a watershed area in the ileocolic region and may facilitate more precise mesenteric dissection. In the present study, we provide proof of concept for the ileocolic watershed area using fluorescence lymphangiography.

Research of Energy Substitution Strategy of China

NASA Astrophysics Data System (ADS)

Zhang, Lifeng; kai, Chen

For a long time, China's energy endowment structure determines the production structure and consumption structure of energy are coal-based.This situation is difficult to change for quite a long time. With the rapid economic growth, industrialization and urbanization, the demand for energy, especially for oil, natural gas will continue to increase. But the oil and gas supply can not meet the needs of rapid growth. The most direct way is to import, and imports will be charged by the international energy situation, and will affect energy and economic security. In view of our country abundant coal resources, we can consider to use coal substituting oil and natural gas to reduce dependence on foreign energy, to strengthen energy and economic security. Therefore, using translog production function, the text forecasts substitution elasticity and the marginal substitution rate between the capital, coal, oil and natural gas, and puts forward substitution program.

Digital FMCW for ultrawideband spectrum sensing

NASA Astrophysics Data System (ADS)

Cheema, A. A.; Salous, S.

2016-08-01

An ultrawideband digital frequency-modulated continuous wave sensing engine is proposed as an alternative technique for cognitive radio applications. A dual-band demonstrator capable of sensing 750 MHz bandwidth in 204.8 µs is presented. Its performance is illustrated from both bench tests and from real-time measurements of the GSM 900 band and the 2.4 GHz wireless local area network (WLAN) band. The measured sensitivity and noise figure values are -90 dBm for a signal-to-noise ratio margin of at least 10 dB and ~13-14 dB, respectively. Data were collected over 24 h and were analyzed by using the energy detection method. The obtained results show the time variability of occupancy, and considerable sections of the spectrum are unoccupied. In addition, unlike the cyclic temporal variations of spectrum occupancy in the GSM 900 band, the detected variations in the 2.4 GHz WLAN band have an impulsive nature.

Sea-level changes and shelf break prograding sequences during the last 400 ka in the Aegean margins: Subsidence rates and palaeogeographic implications

NASA Astrophysics Data System (ADS)

Lykousis, V.

2009-09-01

The subsidence rates of the Aegean margins during the Middle-Upper Pleistocene were evaluated based on new and historical seismic profiling data. High-resolution seismic profiling (AirGun, Sparker and 3.5 kHz) have shown that (at least) four major oblique prograding sequences can be traced below the Aegean marginal slopes at increasing subbottom depths. These palaeo-shelf break glacial delta sediments have been developed during successive low sea-level stands (LST prograding sequences), suggesting continuous and gradual subsidence of the Aegean margins during the last 400 ka. Subsidence rates of the Aegean margins were calculated from the vertical displacement of successive topset-to-foreset transitions (palaeo-shelf break) of the LST prograding sediment sequences. The estimated subsidence rates that were calculated in the active boundaries of the Aegean microplate (North Aegean margins, Gulfs of Patras and Corinth) are high and range from 0.7 to 1.88 m ka -1, while the lowest values (0.34-0.60 m ka -1) are related to the low tectonic and seismic activity margins like the margin of Cyclades plateau. Lower subsidence rates (0.34-0.90 m ka -1) were estimated for the period 146-18 ka BP (oxygen isotopic stages 6-2) and higher (1.46-1.88 m ka -1) for the period from 425 to 250 ka BP (oxygen isotopic stages 12/10-8). A decrease of about 50% of the subduction rates in the Aegean margins was observed during the last 400 ka. During the isotopic stages 8, 10, 11 and 12, almost the 50-60% of the present Aegean Sea was land with extensive drainage systems and delta plains and large lakes in the central and North Aegean. Marine transgression in the North Aegean was rather occurred during the isotopic 9 interglacial period. The estimated palaeomorphology should imply fan delta development and sediment failures in the steep escarpments of the North Aegean margins and high sedimentation rates and turbidite sediment accumulation in the basins. It is deduced that the Black Sea was isolated from the Mediterranean during the Pleistocene prior oxygen isotopic stage 5.

Resampling to accelerate cross-correlation searches for continuous gravitational waves from binary systems

NASA Astrophysics Data System (ADS)

Meadors, Grant David; Krishnan, Badri; Papa, Maria Alessandra; Whelan, John T.; Zhang, Yuanhao

2018-02-01

Continuous-wave (CW) gravitational waves (GWs) call for computationally-intensive methods. Low signal-to-noise ratio signals need templated searches with long coherent integration times and thus fine parameter-space resolution. Longer integration increases sensitivity. Low-mass x-ray binaries (LMXBs) such as Scorpius X-1 (Sco X-1) may emit accretion-driven CWs at strains reachable by current ground-based observatories. Binary orbital parameters induce phase modulation. This paper describes how resampling corrects binary and detector motion, yielding source-frame time series used for cross-correlation. Compared to the previous, detector-frame, templated cross-correlation method, used for Sco X-1 on data from the first Advanced LIGO observing run (O1), resampling is about 20 × faster in the costliest, most-sensitive frequency bands. Speed-up factors depend on integration time and search setup. The speed could be reinvested into longer integration with a forecast sensitivity gain, 20 to 125 Hz median, of approximately 51%, or from 20 to 250 Hz, 11%, given the same per-band cost and setup. This paper's timing model enables future setup optimization. Resampling scales well with longer integration, and at 10 × unoptimized cost could reach respectively 2.83 × and 2.75 × median sensitivities, limited by spin-wandering. Then an O1 search could yield a marginalized-polarization upper limit reaching torque-balance at 100 Hz. Frequencies from 40 to 140 Hz might be probed in equal observing time with 2 × improved detectors.

The Zambezi sedimentary system (coastal plain - deep sea fan): a record of the vertical movements of the Mozambican margin since Cretaceous times.

NASA Astrophysics Data System (ADS)

Ponte, Jean Pierre; Robin, Cecile; Guillocheau, Francois; Baby, Guillaume; Dall'Asta, Massimo; Popescu, Speranta; Suc, Jean Pierre; Droz, Laurence; Rabineau, Marina; Moulin, Maryline

2016-04-01

The Mozambique margin is an oblique to transform margin which feeds one of the largest African turbiditic system, the Zambezi deep-sea fan (1800 km length and 400 km wide; Droz and Mougenot., AAPG Bull., 1987). The Zambezi sedimentary system is characterized by (1) a changing catchment area through time with evidences of river captures (Thomas and Shaw, J. Afr. Earth. Sci, 1988) and (2) a delta, storing more than 12 km of sediment, with no gravitary tectonics. The aim of this study is to carry out a source to sink study along the Zambezi sedimentary system and to analyse the margin evolution (vertical movements, climate change) since Early Cretaceous times. The used data are seismic lines (industrial and academic) and petroleum wells (with access to the cuttings). Our first objective was to perform a new biochronostratigraphic framework based on nannofossils, foraminifers, pollen and spores on the cuttings of three industrial wells. The second target was to recognize the different steps of the growth of the Zambezi sedimentary systems. Four main phases were identified: • Late Jurassic (?) - early Late Cretaceous: from Neocomian to Aptian times, the high of the clinoforms is getting higher, with the first occurrence of contouritic ridges during Aptian times. • Late Cretaceous - Early Paleocene: a major drop of relative sea-level occurred as a consequence of the South African Plateau uplift. The occurrence of two depocenters suggests siliciclastic supplies from the Bushveld and from the North Mozambique domain. • Early Paleocene - Eocene: growth of carbonate platforms and large contouritic ridges. • Oligocene - Present-day: birth of the modern Zambezi Delta, with quite low siliciclastic supply during Oligocene times, increasing during Miocene times. As previously expected (Droz and Mougenot) some sediments of the so-called Zambezi fans are coming from a feeder located east of the Davie Ridge. This study was founded by TOTAL and IFREMER in the frame of the research project PAMELA (Passive Margin Exploration Laboratories).

Gaming out online: Black lesbian identity development and community building in Xbox Live.

PubMed

Gray, Kishonna L

2017-11-22

As gaming culture continues to marginalize women and people of color, other gamers are also highlighting the inequalities they face within digital gaming communities. While heterosexism and homophobia are commonplace within gaming culture, little is known about the actual experiences of "gaymers" and even less about "gaymers" of color. As such, this article seeks to explore lesbians of color and their experiences "gayming" out and online. Exploring identity development, community building, and connectivity via social networking, the women within this study articulate what it means to be lesbian online and how this impacts their physical and digital experiences. The private spaces within gaming culture that many marginalized groups inhabit are the few spaces that value the articulation of marginalized interests and viewpoints. Ethnographic observations reveal how supportive communities can improve resilience by mitigating the effects of stereotyping, microaggressions, and other discriminatory practices in online gaming.

Cascadia Gas Vent Distribution and Challenges to Quantify Margin-Wide Methane Fluxes

NASA Astrophysics Data System (ADS)

Scherwath, M.; Riedel, M.; Roemer, M.; Veloso, M.; Heesemann, M.; Spence, G.

2017-12-01

Gas venting along the Cascadia Margin has been mapped over decades with ship sonar and in recent years with permanent seafloor installations utilizing the seafloor observatories NEPTUNE of Ocean Networks Canada and the Cabled Array of the Ocean Observatories Initiative. We show the distribution of over 1000 vents, most on the shallow shelf. For a third of the vents we have estimated methane flow rates, ranging from 0.05 to 69 L/min, and extrapolate these results to a margin-wide methane flow estaimate of around 4 Mt/yr (at surface pressure and temperature) and a flux estimate of 0.05 kg yr-1 m-2. However, these estimates are based on several assumptions, e.g. bubble sizes or data coverage, providing large uncertainties. With continued research expeditions and potential seafloor calibration experiments, these data can be refined and improved in future years.

Cenozoic Source-to-Sink of the African margin of the Equatorial Atlantic

NASA Astrophysics Data System (ADS)

Rouby, Delphine; Chardon, Dominique; Huyghe, Damien; Guillocheau, François; Robin, Cecile; Loparev, Artiom; Ye, Jing; Dall'Asta, Massimo; Grimaud, Jean-Louis

2016-04-01

The objective of the Transform Source to Sink Project (TS2P) is to link the dynamics of the erosion of the West African Craton to the offshore sedimentary basins of the African margin of the Equatorial Atlantic at geological time scales. This margin, alternating transform and oblique segments from Guinea to Nigeria, shows a strong structural variability in the margin width, continental geology and relief, drainage networks and subsidence/accumulation patterns. We analyzed this system combining onshore geology and geomorphology as well as offshore sub-surface data. Mapping and regional correlation of dated lateritic paleo-landscape remnants allows us to reconstruct two physiographic configurations of West Africa during the Cenozoic. We corrected those reconstitutions from flexural isostasy related to the subsequent erosion. These geometries show that the present-day drainage organization stabilized by at least 29 Myrs ago (probably by 34 Myr) revealing the antiquity of the Senegambia, Niger and Volta catchments toward the Atlantic as well as of the marginal upwarp currently forming a continental divide. The drainage rearrangement that lead to this drainage organization was primarily enhanced by the topographic growth of the Hoggar swell and caused a major stratigraphic turnover along the Equatorial margin of West Africa. Elevation differences between paleo-landscape remnants give access to the spatial and temporal distribution of denudation for 3 time-increments since 45 Myrs. From this, we estimate the volumes of sediments and associated lithologies exported by the West African Craton toward different segments of the margin, taking into account the type of eroded bedrock and the successive drainage reorganizations. We compare these data to Cenozoic accumulation histories in the basins and discuss their stratigraphic expression according to the type of margin segment they are preserved in.

Prospective multicenter study of marginal bone level and soft tissue health of a one-piece implant after two years.

PubMed

Finne, Kaj; Rompen, Eric; Toljanic, Joseph

2007-06-01

A novel 1-piece implant purported to provide for stable tissue support, immediate function, and immediate placement in extraction sockets has been developed. Stabilization of the marginal bone level over time requires documentation. The aim of this study was to evaluate marginal bone level differences and soft tissue health between the 1- and 2-year follow-up of a 1-piece implant design. Eighty-two implants, restoring both single teeth and multiple edentulous situations, in 56 consecutively treated patients, were included. Marginal bone level was evaluated on radiographs made at implant insertion, 6-month follow-up, and annually thereafter. At 3-, 6-month, and 1-year follow-ups, presence of plaque and the soft tissue response were evaluated using plaque and bleeding on probing indexes. The papilla index was used to determine papilla size at implant insertion with the provisional restoration in place and at the insertion of the definitive restoration. The change over time in marginal bone level was analyzed with a 1-way analysis of variance (ANOVA) paired design with time as main effect (1 to 2 years) and subjects as block effect (alpha=.05). One implant failure occurred, resulting in a 98.8% cumulative survival rate (CSR) for the follow-up time of 2 years. The mean (SD) change in bone level between years 1 and 2 was 0.08 mm (1.19) (95% CI-0.30 to 0.46) (P=.68), demonstrating a stable marginal bone level. Normal implant mucosa was noted for approximately 90% of the sites at the 1-year follow-up. The mean (SD) papilla score at placement was 1.3 (0.66) and increased to 1.7 (0.67) at insertion of the definitive prosthesis. The stable marginal bone level and soft tissue health observed indicate that the 1-piece implant tested has the ability to preserve both hard and soft tissue. Based on the high implant survival rate and favorable tissue response, the 1-piece implant can be recommended for clinical use.

Utterance selection model of language change

NASA Astrophysics Data System (ADS)

Baxter, G. J.; Blythe, R. A.; Croft, W.; McKane, A. J.

2006-04-01

We present a mathematical formulation of a theory of language change. The theory is evolutionary in nature and has close analogies with theories of population genetics. The mathematical structure we construct similarly has correspondences with the Fisher-Wright model of population genetics, but there are significant differences. The continuous time formulation of the model is expressed in terms of a Fokker-Planck equation. This equation is exactly soluble in the case of a single speaker and can be investigated analytically in the case of multiple speakers who communicate equally with all other speakers and give their utterances equal weight. Whilst the stationary properties of this system have much in common with the single-speaker case, time-dependent properties are richer. In the particular case where linguistic forms can become extinct, we find that the presence of many speakers causes a two-stage relaxation, the first being a common marginal distribution that persists for a long time as a consequence of ultimate extinction being due to rare fluctuations.

Robustness analysis of multirate and periodically time varying systems

NASA Technical Reports Server (NTRS)

Berg, Martin C.; Mason, Gregory S.

1991-01-01

A new method for analyzing the stability and robustness of multirate and periodically time varying systems is presented. It is shown that a multirate or periodically time varying system can be transformed into an equivalent time invariant system. For a SISO system, traditional gain and phase margins can be found by direct application of the Nyquist criterion to this equivalent time invariant system. For a MIMO system, structured and unstructured singular values can be used to determine the system's robustness. The limitations and implications of utilizing this equivalent time invariant system for calculating gain and phase margins, and for estimating robustness via singular value analysis are discussed.

Sedimentation patterns in the Barberton Mountain Land, South Africa, and the Pilbara Block, Australia: Evidence for Archean rifted continental margins

NASA Astrophysics Data System (ADS)

Eriksson, Kenneth A.

1982-01-01

Archean supracrustal sequences in the Barberton Mountain Land, South Africa, and the Pilbara Block, Australia, consist of lower volcanic and upper dominantly terrigenous clastic intervals. As evidenced by the paleoenvironments of intercalated sedimentary horizons, volcanism occurred mainly in shallow waters. The overlying ca 3.3 Ga sedimentary intervals contain various common as well as unique paleoenvironments, the understanding of which places significant constraints on Archean crustal models. Lateral and vertical associations of inferred paleoenvironments are used to interpret the geotectonic history of the Archean depositories. The early sedimentary history of the greenstone belts is characterized by terrestrial and subaqueous graben-fill associations of facies related to the initial rift stage of basin development. Continued rifting and initial spreading produced submarine grabens within which ironformations accumulated in response to waning volcanism. Source area uplift resulted in progradation of submarine fans across the basinal chemical sediments. The turbidites are gradational directly into braided alluvial sediments, in part of fan delta origin, suggesting that the continental to marine transition occurred along a narrow continental shelf. In the Barberton Mountain Land the steep-rift margin was succeeded by the development of a stable continental shelf or shelf rise margin through progradation of the turbidite wedge possibly in association with a eustatic rise in sea-level related to continued spreading. On this shelf extensive tidal, deltaic and barrier beach sediments accumulated. Sedimentation was terminated by closure of the passive margin oceans. The late-Archean Pongola Supergroup in South Africa is considered to be the late-orogenic molasse response to this closure and represents the completion of the Wilson cycle.

Evolution of the Andaman Sea region: Dextral transtension as consequence of the India-Asia collision

NASA Astrophysics Data System (ADS)

Zhang, L.; Xu, J.; Ben-Avraham, Z.; Kelty, T. K.

2010-12-01

The two gigantic conjugate strike-slip faults: the Altyn Fault and the Sagaing Fault in northwest and southeast of the proto-Tibet plateau respectively, began to form as consequence of initiation of the India-Asia collision at around 50 Ma (Xu, 2005; Xu et al., 2010). The Sagaing Fault, Andaman trench fault as well as the Sumatra Fault controlled the evolution of the Andaman Sea region while the collision proceeded. By synthesis of geometry and rifting history of the Andaman Sea Basin and Mergui Basin and the plate tectonic setting, we suggest the following five-stage evolution model for the Andaman Sea region: (1) dextral pull-apart rifting and seafloor spreading from 50 Ma to 32 Ma; (2) dextral transform margin-type rifting was active in Mergui Basin with principal fault being the Sumatran Fault system, and both the transform margin-type rifting and the dextral pull-apart rifting were coevally active in the Andaman Sea Basin during 32 Ma to 20 Ma, when the Sumatra fault rotated CW enough and obliquity of subduction of the Indian plate motion along the Sumatra trench was enough to trigger the dextral displacement to take place on the Sumatra Fault system and the Mottawi fault; (3) the Alcock and Sewell plateaus formed in the Andaman Sea by the NNW transtension and the transform margin-type rifting continued in the Mergui basin during 20 Ma to 15 Ma; (4) NNW weak transtensional rifting on the Alcock and Sewell plateaus and NW weak transform margin-type rifting continued in the Mergui basin during 15 Ma to 5 Ma; (5)transtensional rifting similar with but more intensive than earlier stage kept on, forming the central Andaman Basin and the East basin, from 5 Ma to present.

Tutorial on Biostatistics: Linear Regression Analysis of Continuous Correlated Eye Data

PubMed Central

Ying, Gui-shuang; Maguire, Maureen G; Glynn, Robert; Rosner, Bernard

2017-01-01

Purpose To describe and demonstrate appropriate linear regression methods for analyzing correlated continuous eye data. Methods We describe several approaches to regression analysis involving both eyes, including mixed effects and marginal models under various covariance structures to account for inter-eye correlation. We demonstrate, with SAS statistical software, applications in a study comparing baseline refractive error between one eye with choroidal neovascularization (CNV) and the unaffected fellow eye, and in a study determining factors associated with visual field data in the elderly. Results When refractive error from both eyes were analyzed with standard linear regression without accounting for inter-eye correlation (adjusting for demographic and ocular covariates), the difference between eyes with CNV and fellow eyes was 0.15 diopters (D; 95% confidence interval, CI −0.03 to 0.32D, P=0.10). Using a mixed effects model or a marginal model, the estimated difference was the same but with narrower 95% CI (0.01 to 0.28D, P=0.03). Standard regression for visual field data from both eyes provided biased estimates of standard error (generally underestimated) and smaller P-values, while analysis of the worse eye provided larger P-values than mixed effects models and marginal models. Conclusion In research involving both eyes, ignoring inter-eye correlation can lead to invalid inferences. Analysis using only right or left eyes is valid, but decreases power. Worse-eye analysis can provide less power and biased estimates of effect. Mixed effects or marginal models using the eye as the unit of analysis should be used to appropriately account for inter-eye correlation and maximize power and precision. PMID:28102741

Effect of patient's age on the profitability of inpatient cardiac catheterization: a contribution margin analysis of frequently performed procedures over a 5-year period.

PubMed

Plehn, Gunnar; Butz, Thomas; Maagh, Petra; Meissner, Axel

2017-01-18

Due to a continuing age shift in the German society hospital providers are concerned about the additional costs associated with the treatment of elderly patients. It is not clear if cardiac catheterization in aged patients leads to higher resource utilization and if DRG-revenues do compensate for this factor. Procedure-related and administrative data of all patients who underwent cardiac catheterization at a tertiary heart center between 2007 and 2011 were collected and analyzed. Then a profitability analysis was performed by comparing the case related variable costs with the Diagnosis-related group (DRG) per case revenues. A particular emphasis was placed on a comparative analysis of identical clusters of procedures. The most frequently performed catheterization procedure (n = 1800) was associated with significantly higher material expenditure in very old patients (178 ± 48 €) than in old (171 ± 28; p = 0.001) and young patients (172 ± 39; p = 0.046). Furthermore, radiation time and the length of hospital stay were increased in very old patients (3.5 ± 3.8 min and 6.2 ± 4.8 days) compared to old (2.7 ± 2.8 min and 4.6 ± 3.8 days; p < 0.001) and young patients (2.5 ± 2.5 min and 4.5 ± 3.9 days; p < 0.001). Due to higher DRG revenues very old patients achieved higher absolute contribution margins (2065 ± 1033 €) than old (1804 ± 1902 €; p < 0.001) and young patients (1771 ± 902 €; p < 0.001). However, the contribution margins per day were significantly smaller (440 ± 226 €) than those in old (488 ± 234 €; p = 0.001) and young patients (484 ± 206 €; p = 0.001). Catheterization of very old patients is related to lower contribution margins per day despite higher material and time expenditures. Since efforts to reduce the length of hospital stay of these patients are limited, this may result in a competitive disadvantage of hospitals which are more affected by the demographic change.

Phanerozoic growth of Asia: Geodynamic processes and evolution

NASA Astrophysics Data System (ADS)

Pubellier, Manuel; Meresse, Florian

2013-08-01

Accretion processes often obscured in mountain belts can be documented with great detail in SE Asia where these have taken place during the Tertiary. The resulting configuration showing accreted continental strips and tectonised wedges is illustrated by the Tethysides jammed between the northern Laurasian cratons (Baltica and Siberia) and Gondwanian cratons (Africa, Arabia, India and Australia). Eurasia increased progressively in size due to the amalgamation of crustal and sedimentary belts. At places where the processes are documented in the recent times, they can be included within a "collision factory" which displays the opening of basins by rifting and sea floor spreading within the upper plate, until they undergo a process of shortening, both stages being subduction-controlled. In SE Asia the early stages are illustrated in the eastern Sunda arc where the subduction of the Sunda Trench is blocked in Sumba and Timor region, and flipped into the Flores Trough in less than 2 My. The incipient shortening is at present taking place in the Pliocene Damar basins. Another stage, where half of the upper plate basin has disappeared, is documented in the Celebes Sea. The examples of deformation being transferred further inland exist in the northern Celebes Sea and the Makassar Basin. The next important stage is the complete consumption of the marginal basin where both margins collide and the accretionary wedge is thrust over the margin, as illustrated in NW Borneo and Palawan. Each of these stages is responsible for a single short-lived tectonic event, the succession of several events composes an orogen which may last for over 10 My. These events predate the arrival of the conjugate margin of the large ocean, which marks the beginning of continental subduction as observed in the Himalaya-Tibet region. These examples show that the closure is generally diachronous through time as illustrated in the Philippines. We observe that the ophiolite obducted in such context is generally of back-arc origin (upper plate) rather than the relict of the vanishing large ocean which is rarely preserved. In the Philippines, once the crust is accreted the subduction zone progressively moved southward until its present position. We propose that the lithospheric mantle of the accreted block is delaminated and rolls back in a continuous manner, whereas the crust is deformed and accreted.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, H; Chen, Z; Nath, R

Purpose: kV fluoroscopic imaging combined with MV treatment beam imaging has been investigated for intrafractional motion monitoring and correction. It is, however, subject to additional kV imaging dose to normal tissue. To balance tracking accuracy and imaging dose, we previously proposed an adaptive imaging strategy to dynamically decide future imaging type and moments based on motion tracking uncertainty. kV imaging may be used continuously for maximal accuracy or only when the position uncertainty (probability of out of threshold) is high if a preset imaging dose limit is considered. In this work, we propose more accurate methods to estimate tracking uncertaintymore » through analyzing acquired data in real-time. Methods: We simulated motion tracking process based on a previously developed imaging framework (MV + initial seconds of kV imaging) using real-time breathing data from 42 patients. Motion tracking errors for each time point were collected together with the time point’s corresponding features, such as tumor motion speed and 2D tracking error of previous time points, etc. We tested three methods for error uncertainty estimation based on the features: conditional probability distribution, logistic regression modeling, and support vector machine (SVM) classification to detect errors exceeding a threshold. Results: For conditional probability distribution, polynomial regressions on three features (previous tracking error, prediction quality, and cosine of the angle between the trajectory and the treatment beam) showed strong correlation with the variation (uncertainty) of the mean 3D tracking error and its standard deviation: R-square = 0.94 and 0.90, respectively. The logistic regression and SVM classification successfully identified about 95% of tracking errors exceeding 2.5mm threshold. Conclusion: The proposed methods can reliably estimate the motion tracking uncertainty in real-time, which can be used to guide adaptive additional imaging to confirm the tumor is within the margin or initialize motion compensation if it is out of the margin.« less

GLORIA mosaic of the Gulf of Alaska and the British Columbia margin: Deep-sea channels, margin deformation, and the Queen Charlotte fault

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bruns, T.R.; Carlson, P.R.; Stevenson, A.J.

1990-05-01

GLORIA images collected from 1986 to 1989 show sea-floor morphology from the shelf break seaward to 400 km in the Gulf of Alaska and a 70-km-wide swath along British Columbia. Along the Aleutian convergent margin sediment is dominantly trapped in mid-slope basins, where few canyons reach the trench. Accretionary wedge structures range from highly discontinuous to long and continuous. The Yakutat transition margin is either extensively cut by dendritic drainages or, at sea-valley mouths, covered by glacially derived sediment. Young structures underlie the slope from Middleton Island to Pamplona Spur, but are absent from Pamplona Spur to Cross Sound. Alongmore » the southeast Alaska transform margin the Queen Charlotte fault is imaged as a narrow linear feature. The fault steps westward at Tuzo Wilson Knolls, which likely is a spreading ridge segment. Large anticlines lie seaward of and trend parallel to the fault. On the abyssal plain off the Shumagin margin inherited structural and bathymetric features trend parallel to magnetic anomalies, and trench parallel features reflect faulting as the ocean plate bends into the trench. To the north, three turbidite systems drain the margin. The Surveyor system begins between Pamplona Spur and Alsek Canyon and empties into the Aleutian Trench. The Chirikof system arises near Cross Sound and ends in turbidite fans south of the Kodiak-Bowie Seamount chain, a relic Chirikov channel that once carried sediment westward to the Aleutian Trench. The Mukluk and Horizon channels start along southeast Alaska and end 1,000 km away on the Tufts abyssal plain.« less

An Integrative Cultural Model to better situate marginalized science students in postsecondary science education

NASA Astrophysics Data System (ADS)

Labouta, Hagar Ibrahim; Adams, Jennifer Dawn; Cramb, David Thomas

2018-03-01

In this paper we reflect on the article "I am smart enough to study postsecondary science: a critical discourse analysis of latecomers' identity construction in an online forum", by Phoebe Jackson and Gale Seiler (Cult Stud Sci Educ. https://doi.org/10.1007/s11422-017-9818-0). In their article, the authors did a significant amount of qualitative analysis of a discussion on an online forum by four latecomer students with past negative experiences in science education. The students used this online forum as an out-of-class resource to develop a cultural model based on their ability to ask questions together with solidarity as a new optimistic way to position themselves in science. In this forum, we continue by discussing the identity of marginalized science students in relation to resources available in postsecondary science classes. Recent findings on a successful case of a persistent marginalized science student in spite of prior struggles and failures are introduced. Building on their model and our results, we proposed a new cultural model, emphasizing interaction between inside and outside classroom resources which can further our understanding of the identity of marginalized science students. Exploring this cultural model could better explain drop-outs or engagement of marginalized science students to their study. We, then, used this model to reflect on both current traditional and effective teaching and learning practices truncating or re-enforcing relationships of marginalized students with the learning environment. In this way, we aim to further the discussion initiated by Jackson and Seiler and offer possible frameworks for future research on the interactions between marginalized students with past low achievements and other high and mid achieving students, as well as other interactions between resources inside and outside science postsecondary classrooms.

Real-time auto-adaptive margin generation for MLC-tracked radiotherapy

NASA Astrophysics Data System (ADS)

Glitzner, M.; Fast, M. F.; de Senneville, B. Denis; Nill, S.; Oelfke, U.; Lagendijk, J. J. W.; Raaymakers, B. W.; Crijns, S. P. M.

2017-01-01

In radiotherapy, abdominal and thoracic sites are candidates for performing motion tracking. With real-time control it is possible to adjust the multileaf collimator (MLC) position to the target position. However, positions are not perfectly matched and position errors arise from system delays and complicated response of the electromechanic MLC system. Although, it is possible to compensate parts of these errors by using predictors, residual errors remain and need to be compensated to retain target coverage. This work presents a method to statistically describe tracking errors and to automatically derive a patient-specific, per-segment margin to compensate the arising underdosage on-line, i.e. during plan delivery. The statistics of the geometric error between intended and actual machine position are derived using kernel density estimators. Subsequently a margin is calculated on-line according to a selected coverage parameter, which determines the amount of accepted underdosage. The margin is then applied onto the actual segment to accommodate the positioning errors in the enlarged segment. The proof-of-concept was tested in an on-line tracking experiment and showed the ability to recover underdosages for two test cases, increasing {{V}90 %} in the underdosed area about 47 % and 41 % , respectively. The used dose model was able to predict the loss of dose due to tracking errors and could be used to infer the necessary margins. The implementation had a running time of 23 ms which is compatible with real-time requirements of MLC tracking systems. The auto-adaptivity to machine and patient characteristics makes the technique a generic yet intuitive candidate to avoid underdosages due to MLC tracking errors.

Holocene Fluctuations of North Ice Cap, a Proxy for Climate Conditions along the Northwestern Margin of the Greenland Ice Sheet

NASA Astrophysics Data System (ADS)

Kelly, M. A.; Osterberg, E. C.; Lasher, G. E.; Farnsworth, L. B.; Howley, J. A.; Axford, Y.; Zimmerman, S. R. H.

2015-12-01

North Ice Cap (~76.9°N, 68°W, summit elevation 1322 m asl), a small, independent ice cap in northwestern Greenland, is located within ~25 km of the Greenland Ice Sheet margin and Harald Molkte Bræ outlet glacier. We present geochronological, geomorphic and sedimentological data constraining the Holocene extents of North Ice Cap and suggest that its past fluctuations can be used as a proxy for climate conditions along the northwestern margin of the Greenland Ice Sheet. Prior work by Goldthwait (1960) used glacial geomorphology and radiocarbon ages of subfossil plants emerging along shear planes in the ice cap margin to suggest that that North Ice Cap was not present during the early Holocene and nucleated in the middle to late Holocene time, with the onset of colder conditions. Subfossil plants emerging at shear planes in the North Ice Cap margin yield radiocarbon ages of ~4.8-5.9 cal kyr BP (Goldthwait, 1960) and ~AD 1000-1350 (950-600 cal yr BP), indicating times when the ice cap was smaller than at present. In situ subfossil plants exposed by recent ice cap retreat date to ~AD 1500-1840 (450-110 cal yr BP) and indicate small fluctuations of the ice cap margin. 10Be ages of an unweathered, lichen-free drift <100 m from the present North Ice Cap margin range from ~500 to 8000 yrs ago. We suggest that the drift was deposited during the last ~500 yrs and that the older 10Be ages are influenced by 10Be inherited from a prior period of exposure. We also infer ice cap fluctuations using geochemical data from a Holocene-long sediment core from Deltasø, a downstream lake that currently receives meltwater from North Ice Cap. The recent recession of the North Ice Cap margin influenced a catastrophic drainage of a large proglacial lake, Søndre Snesø, that our field team documented in August 2012. To our knowledge, this is the first significant lowering of Søndre Snesø in historical time.

JointMMCC: Joint Maximum-Margin Classification and Clustering of Imaging Data

PubMed Central

Filipovych, Roman; Resnick, Susan M.; Davatzikos, Christos

2012-01-01

A number of conditions are characterized by pathologies that form continuous or nearly-continuous spectra spanning from the absence of pathology to very pronounced pathological changes (e.g., normal aging, Mild Cognitive Impairment, Alzheimer's). Moreover, diseases are often highly heterogeneous with a number of diagnostic subcategories or subconditions lying within the spectra (e.g., Autism Spectrum Disorder, schizophrenia). Discovering coherent subpopulations of subjects within the spectrum of pathological changes may further our understanding of diseases, and potentially identify subconditions that require alternative or modified treatment options. In this paper, we propose an approach that aims at identifying coherent subpopulations with respect to the underlying MRI in the scenario where the condition is heterogeneous and pathological changes form a continuous spectrum. We describe a Joint Maximum-Margin Classification and Clustering (JointMMCC) approach that jointly detects the pathologic population via semi-supervised classification, as well as disentangles heterogeneity of the pathological cohort by solving a clustering subproblem. We propose an efficient solution to the non-convex optimization problem associated with JointMMCC. We apply our proposed approach to an MRI study of aging, and identify coherent subpopulations (i.e., clusters) of cognitively less stable adults. PMID:22328179

Omental patch repair effectively treats perforated marginal ulcer following Roux-en-Y gastric bypass.

PubMed

Wendling, Mark R; Linn, John G; Keplinger, Kara M; Mikami, Dean J; Perry, Kyle A; Melvin, W Scott; Needleman, Bradley J

2013-02-01

Marginal ulcer formation remains a significant complication of Roux-en-Y gastric bypass (RYGB). Up to 1 % of all RYGB patients will develop free perforation of a marginal ulcer. Classically, this complication has required anastomotic revision; however, this approach is associated with significant morbidity. Several small series have suggested that omental patch repair may be effective. The aim of this study was to examine the management of perforated marginal ulcers following RYGB. All patients who underwent operative intervention for perforated ulcers between 2003 and 2011 were reviewed. Those with a history of RYGB with perforation of a marginal ulcer were included in the analysis. Data collected included operative approach, operative time, blood loss, length of hospital stay, complications, smoking history, and steroid or NSAID use. From January 2003 to December 2011, a total of 1,760 patients underwent RYGB at our institution. Eighteen (0.85 %) developed perforation of a marginal ulcer. Three patients' original procedure was performed at another institution. Eight patients (44 %) had at least one risk factor for ulcer formation. Treatment included omental patch repair (laparoscopic, n = 7; open, n = 9) or anastomotic revision (n = 2). Compared to anastomotic revision, omental patch repair had shorter OR time (101 ± 57 vs. 138 ± 2 min), decreased estimated blood loss (70 ± 72 vs. 250 ± 71 mL), and shorter total length of stay (5.6 ± 1.4 vs. 11.0 ± 5.7 days). Perforated marginal ulcer represents a significant complication of RYGB. Patients should be educated to reduce risk factors for perforation, as prolonged proton pump inhibitor therapy may not prevent this complication in a patient with even just one risk factor. In our sample population we found laparoscopic or open omental patch repair to be a safe and effective treatment for this condition and it was associated with decreased operative time, blood loss, and length of stay.

Time-resolved GRB spectra in the complex radiation of synchrotron and Compton processes

NASA Astrophysics Data System (ADS)

Jiang, Y. G.; Hu, S. M.; Chen, X.; Li, K.; Guo, D. F.; Li, Y. T.; Li, H. Z.; Zhao, Y. Y.; Lin, H. N.; Chang, Z.

2016-03-01

Under the steady-state condition, the spectrum of electrons is investigated by solving the continuity equation under the complex radiation of both the synchrotron and Compton processes. The resulted gamma-ray burst (GRB) spectrum is a broken power law in both the fast and slow cooling phases. On the basis of this electron spectrum, the spectral indices of the Band function in four different phases are presented. In the complex radiation frame, the detail investigation on physical parameters reveals that three models can answer the α ˜ -1 problem, which are the synchrotron plus synchrotron self-Compton in the internal and the external shock models, and the synchrotron plus the external Compton processes in the external shock model. A possible marginal to fast cooling phase transition in GRB 080916C is discussed. The time-resolved spectra in different main pulses of GRB 100724B, GRB 100826A and GRB 130606B are investigated. We found that the flux is proportional to the peak energy in almost all main pulses. A significant (5σ) correlation for Fp ˜ Ep is evident the first main pulse of GRB 100826A, and three marginally significant (3σ) correlations Fp ˜ Ep are found in main pulses of GRB 100826A and GRB 130606B. The correlation between spectral index and Ep at 3 ˜ 4σ level are observed in the first main pulse of GRB 100826A. Such correlations are possible explained in the complex radiation scenario.

The Transition from Volcanic to Rift Dominated Crustal Breakup - From the Vøring Plateau to the Lofoten Margin, Norway

NASA Astrophysics Data System (ADS)

Breivik, A. J.; Faleide, J. I.; Mjelde, R.; Flueh, E.; Murai, Y.

2017-12-01

The Vøring Plateau was part of the Northeast Atlantic igneous province (NAIP) during early Cenozoic crustal breakup. Crustal breakup at the Vøring Plateau occurred marginal to the deep Cretaceous basins on the shelf, with less extension of the crust. Intrusive magmatism and oceanic crust up to three times normal thickness caused a period of sub-aerial magmatism around breakup time. The transition to the Lofoten Margin is rapid to a deep-water plain. Still, there is some excess magmatism north of this transition, where early oceanic crustal thickness is reduced to half of that of the Vøring Plateau 150 km away. Our estimates of the earliest seafloor spreading rates using new ship-track magnetic profiles on different margin segments offer a clue to what caused this rapid transition. While crustal breakup occurred within the magnetic polarity C24r in other parts of the NAIP, there is a delayed breakup for the Lofoten/Vesterålen margin. Modeling of the earliest seafloor spreading with geomagnetic reversals, indicate a breakup within C24n.3n (anomaly 24b), approximately 1 m.y. later. Both old wide-angle seismic models (from Ocean Bottom Seismometers) off southern Lofoten and a newly published profile farther north show a strongly extended outer margin. Applying early seafloor half-spreading rates ( 30 mm/y) from other NAIP margin segments for 1 m.y. can account for 30 km extra extension, giving a factor of three crustal thinning, and gives a high strain rate of 3.2 ·10-14. Crustal breakup at the magma-poor Iberian Margin occurred at a low strain rate of 4.4·10-15, allowing the ascending mantle to cool, favoring tectonic extension over magmatism. Similar strain rates are found within the main Ethiopian Rift, but there is much magmatism and crustal separation is dominated by dike injection. Mantle tomography models show an exceptionally low seismic velocity below the area interpreted as an unusually hot upper mantle, which will favor magmatism. The transition from the Vøring Plateau to the Lofoten Margin can therefore be explained by the presence/absence of hot mantle plume material under the different segments during rifting. Only after significant extension and close to crustal breakup time did a minor amount of plume material reach the Lofoten/Vesterålen margin to cause some elevated but short-lived excess magmatism there.

Constructing inverse probability weights for continuous exposures: a comparison of methods.

PubMed

Naimi, Ashley I; Moodie, Erica E M; Auger, Nathalie; Kaufman, Jay S

2014-03-01

Inverse probability-weighted marginal structural models with binary exposures are common in epidemiology. Constructing inverse probability weights for a continuous exposure can be complicated by the presence of outliers, and the need to identify a parametric form for the exposure and account for nonconstant exposure variance. We explored the performance of various methods to construct inverse probability weights for continuous exposures using Monte Carlo simulation. We generated two continuous exposures and binary outcomes using data sampled from a large empirical cohort. The first exposure followed a normal distribution with homoscedastic variance. The second exposure followed a contaminated Poisson distribution, with heteroscedastic variance equal to the conditional mean. We assessed six methods to construct inverse probability weights using: a normal distribution, a normal distribution with heteroscedastic variance, a truncated normal distribution with heteroscedastic variance, a gamma distribution, a t distribution (1, 3, and 5 degrees of freedom), and a quantile binning approach (based on 10, 15, and 20 exposure categories). We estimated the marginal odds ratio for a single-unit increase in each simulated exposure in a regression model weighted by the inverse probability weights constructed using each approach, and then computed the bias and mean squared error for each method. For the homoscedastic exposure, the standard normal, gamma, and quantile binning approaches performed best. For the heteroscedastic exposure, the quantile binning, gamma, and heteroscedastic normal approaches performed best. Our results suggest that the quantile binning approach is a simple and versatile way to construct inverse probability weights for continuous exposures.

Prospective Analysis of Surgical Bone Margins After Partial Foot Amputation in Diabetic Patients Admitted With Moderate to Severe Foot Infections.

PubMed

Schmidt, Brian M; McHugh, Jonathan B; Patel, Rajiv M; Wrobel, James S

2018-04-01

Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Secondary aims included evaluating interobserver reliability of histopathologic data at both the distal-to and proximal-to surgical bone margin. Data were prospectively collected on 72 individuals and was pooled for analysis. Standardized method to retrieve intraoperative bone margins was established. A univariate analysis was performed. Negative outcomes, including major lower extremity amputation, wound dehiscence, reulceration, reamputation, or death were recorded. Viable proximal margins were obtained in 63 out of 72 cases (87.5%). Strong interobserver reliability of histopathology was recorded. Univariate analysis demonstrated preoperative platelets, albumin, probe-to-bone testing, absolute toe pressures, smaller wound surface area were associated with obtaining viable margins. Residual osteomyelitis resulted in readmission 2.6 times more often and more postoperative complications. Certain patients were significantly different in the viable margin group versus dirty margin group. High interobserver reliability was demonstrated. Obtainment of viable margins resulted in reduced rates of readmission and negative outcomes. Prognostic, Level I: Prospective.

Role of specimen US for predicting resection margin status in breast conserving therapy.

PubMed

Moschetta, M; Telegrafo, M; Introna, T; Coi, L; Rella, L; Ranieri, V; Cirili, A; Stabile Ianora, A A; Angelelli, G

2015-01-01

To assess the diagnostic accuracy of specimen ultrasound (US) for predicting resection margin status in women undergoing breast conserving therapy for US-detected cancer, having the histological findings as the reference standard. A total of 132 consecutive patients (age range, 34-87 years; mean, 51 years) underwent breast-conserving surgery for US-detected invasive breast cancer. All surgical specimens underwent US examination. The presence of lesion within the specimen and its distance from the specimen margins were assessed considering a threshold distance between the lesion and specimen margins of 10 mm. US findings were then compared with the pathological ones and specimen US. Sensitivity, specificity, diagnostic accuracy, positive (PPV) and negative predictive values (NPV) for predicting histological margin status were evaluated, having the histological findings as the reference standard. The histological examination detected invasive ductal carcinoma in 96/132 (73%) cases, invasive lobular carcinoma in 32/132 (24%), mucinous carcinoma in 4/132 (3%). The pathological margin analysis revealed 96/132 (73%) negative margins and 36 (27%) close/positive margins. US examination detected all 132 breast lesions within the surgical specimens. 110 (83%) negative margins and 22 (17%) positive margins were found on US. Sensitivity, specificity, diagnostic accuracy, PPV and NPV of 44%, 94%, 80%, 73% and 82%, respectively, were found for specimen US. Specimen US represents a time and cost saving imaging tool for evaluating the presence of US detected-breast lesion within surgical specimen and for predicting the histological margin status.

Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy.

PubMed

Bickford, Lissett R; Agollah, Germaine; Drezek, Rebekah; Yu, Tse-Kuan

2010-04-01

Obtaining negative margins is critical for breast cancer patients undergoing conservation therapy in order to reduce the reemergence of the original cancer. Currently, breast cancer tumor margins are examined in a pathology lab either while the patient is anesthetized or after the surgical procedure has been terminated. These current methods often result in cancer cells present at the surgical resection margin due to inadequate margin assessment at the point of care. Due to such limitations evident in current diagnoses, tools for increasing the accuracy and speed of tumor margin detection directly in the operating room are still needed. We are exploring the potential of using a nano-biophotonics system to facilitate intraoperative tumor margin assessment ex vivo at the cellular level. By combining bioconjugated silica-based gold nanoshells, which scatter light in the near-infrared, with a portable FDA-approved reflectance confocal microscope, we first validate the use of gold nanoshells as effective reflectance-based imaging probes by evaluating the contrast enhancement of three different HER2-overexpressing cell lines. Additionally, we demonstrate the ability to detect HER2-overexpressing cells in human tissue sections within 5 min of incubation time. This work supports the use of targeted silica-based gold nanoshells as potential real-time molecular probes for HER2-overexpression in human tissue.

Statistical Analysis of Categorical Time Series of Atmospheric Elementary Circulation Mechanisms - Dzerdzeevski Classification for the Northern Hemisphere

PubMed Central

Brenčič, Mihael

2016-01-01

Northern hemisphere elementary circulation mechanisms, defined with the Dzerdzeevski classification and published on a daily basis from 1899–2012, are analysed with statistical methods as continuous categorical time series. Classification consists of 41 elementary circulation mechanisms (ECM), which are assigned to calendar days. Empirical marginal probabilities of each ECM were determined. Seasonality and the periodicity effect were investigated with moving dispersion filters and randomisation procedure on the ECM categories as well as with the time analyses of the ECM mode. The time series were determined as being non-stationary with strong time-dependent trends. During the investigated period, periodicity interchanges with periods when no seasonality is present. In the time series structure, the strongest division is visible at the milestone of 1986, showing that the atmospheric circulation pattern reflected in the ECM has significantly changed. This change is result of the change in the frequency of ECM categories; before 1986, the appearance of ECM was more diverse, and afterwards fewer ECMs appear. The statistical approach applied to the categorical climatic time series opens up new potential insight into climate variability and change studies that have to be performed in the future. PMID:27116375

Statistical Analysis of Categorical Time Series of Atmospheric Elementary Circulation Mechanisms - Dzerdzeevski Classification for the Northern Hemisphere.

PubMed

Brenčič, Mihael

2016-01-01

Northern hemisphere elementary circulation mechanisms, defined with the Dzerdzeevski classification and published on a daily basis from 1899-2012, are analysed with statistical methods as continuous categorical time series. Classification consists of 41 elementary circulation mechanisms (ECM), which are assigned to calendar days. Empirical marginal probabilities of each ECM were determined. Seasonality and the periodicity effect were investigated with moving dispersion filters and randomisation procedure on the ECM categories as well as with the time analyses of the ECM mode. The time series were determined as being non-stationary with strong time-dependent trends. During the investigated period, periodicity interchanges with periods when no seasonality is present. In the time series structure, the strongest division is visible at the milestone of 1986, showing that the atmospheric circulation pattern reflected in the ECM has significantly changed. This change is result of the change in the frequency of ECM categories; before 1986, the appearance of ECM was more diverse, and afterwards fewer ECMs appear. The statistical approach applied to the categorical climatic time series opens up new potential insight into climate variability and change studies that have to be performed in the future.

Significance of post-resection tissue shrinkage on surgical margins of oral squamous cell carcinoma.

PubMed

El-Fol, Hossam Abdelkader; Noman, Samer Abduljabar; Beheiri, Mohamed Galal; Khalil, Abdalla M; Kamel, Mahmoud Mohamed

2015-05-01

Resecting oral squamous cell carcinoma (SCC) with an appropriate margin of uninvolved tissue is critical in preventing local recurrence and in making decisions regarding postoperative radiation therapy. This task can be difficult due to the discrepancy between margins measured intraoperatively and those measured microscopically by the pathologist after specimen processing. A total of 61 patients underwent resective surgery with curative intent for primary oral SCC were included in this study. All patients underwent resection of the tumor with a measured 1-cm margin. Specimens were then submitted for processing and reviewing, and histopathologic margins were measured. The closest histopathologic margin was compared with the in situ margin (1 cm) to determine the percentage discrepancy. The mean discrepancy between the in situ margins and the histopathological margins of all close and positive margins were 47.6% for the buccal mucosa (with a P value corresponding to 0.05 equaling 2.1), which is statistically significant, 4.8% for the floor of mouth, 9.5% for the mandibular alveolus, 4.8% for the retromolar trigon, and 33.3% for the tongue. There is a significant difference among resection margins based on tumor anatomical location. Margins shrinkage after resection and processing should be considered at the time of the initial resection. Tumors located in the buccal mucosa show significantly greater discrepancies than tumors at other sites. These findings suggest that it is critical to consider the oral site when outlining margins to ensure adequacy of resection. Buccal SCC is an aggressive disease, and should be considered as an aggressive subsite within the oral cavity, requiring a radical and aggressive resective approach. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Spectrally encoded confocal microscopy (SECM) for rapid assessment of breast excision specimens (Conference Presentation)

NASA Astrophysics Data System (ADS)

Brachtel, Elena F.; Johnson, Nicole B.; Huck, Amelia E.; Rice-Stitt, Travis L.; Vangel, Mark G.; Smith, Barbara L.; Tearney, Guillermo J.; Kang, DongKyun

2016-03-01

Unacceptably large percentage (20-40%) of breast cancer lumpectomy patients are required to undergo multiple surgeries when positive margins are found upon post-operative histologic assessment. If the margin status can be determined during surgery, surgeon can resect additional tissues to achieve tumor-free margin, which will reduce the need for additional surgeries. Spectrally encoded confocal microscopy (SECM) is a high-speed reflectance confocal microscopy technology that has a potential to image the entire surgical margin within a short procedural time. Previously, SECM was shown to rapidly image a large area (10 mm by 10 mm) of human esophageal tissue within a short procedural time (15 seconds). When used in lumpectomy, SECM will be able to image the entire margin surface of ~30 cm2 in around 7.5 minutes. SECM images will then be used to determine margin status intra-operatively. In this paper, we present results from a study of testing accuracy of SECM for diagnosing malignant breast tissues. We have imaged freshly-excised breast specimens (N=46) with SECM. SECM images clearly visualized histomorphologic features associated with normal/benign and malignant breast tissues in a similar manner to histologic images. Diagnostic accuracy was tested by comparing SECM diagnoses made by three junior pathologists with corresponding histologic diagnoses made by a senior pathologist. SECM sensitivity and specificity were high, 0.91 and 0.93, respectively. Intra-observer agreement and inter-observer agreement were also high, 0.87 and 0.84, respectively. Results from this study showed that SECM has a potential to accurately determine margin status during breast cancer lumpectomy.

Marginal Fit of Metal-Ceramic Copings: Effect of Luting Cements and Tooth Preparation Design.

PubMed

de Almeida, Juliana Gomes Dos Santos Paes; Guedes, Carlos Gramani; Abi-Rached, Filipe de Oliveira; Trindade, Flávia Zardo; Fonseca, Renata Garcia

2017-12-22

To evaluate the effect of the triad finish line design, axial wall convergence angle, and luting cement on the marginal fit of metal copings used in metal-ceramic crowns. Schematic dies and their respective copings were cast in NiCr alloy. The dies exhibited the following finish line/convergence angle combinations: sloping shoulder/6°, sloping shoulder/20°, shoulder/6°, shoulder/20°. Marginal fit was evaluated under a stereomicroscope, before and after cementation. Copings were air-abraded with 50 μm Al 2 O 3 particles and cemented with Cimento de Zinco, RelyX U100, or Panavia F cements (n = 10/group). Data were square-root transformed and analyzed by 3-way factorial random effect model and Tukey's post hoc test (α = 0.05). Statistical analysis showed significance for the interactions finish line and convergence angle (p < 0.05), convergence angle and time (p < 0.001), and luting cement and time (p < 0.001). Sloping shoulder/20° provided the highest marginal discrepancy when compared to the other finish line/convergence angle combinations, which were statistically similar among each other. For both convergence angles and for all luting cements, the marginal discrepancy was significantly higher after cementation. Before and after cementation, 6° provided better marginal fit than 20°. After cementation, Panavia F provided higher marginal discrepancy than Cimento de Zinco. Lower convergence angle combined with shoulder and a low-consistency luting cement is preferable to cement metal copings. © 2017 by the American College of Prosthodontists.

Tectonic development of passive continental margins of the southern and central Red Sea with a comparison to Wilkes Land, Antarctica

USGS Publications Warehouse

Bohannon, R.G.; Eittreim, S.L.

1991-01-01

The continental margins of the southern and central Red Sea and most of Wilkes Land, Antarctica have bulk crustal configurations and detailed structures that are best explained by a prolonged history of magmatic expansion that followed a brief, but intense period of mechanical extension. Extension on the Red Sea margins was spatially confined to a rift that was 20-30 km in width. The rifting phase along the Arabian margin of the central and southern Red Sea occurred 25-32 Ma ago, primarily by detachment faulting at upper crustal levels and ductile uniform stretching at depth. Rifting was followed by an early magmatic phase during which the margin was invaded by dikes and plutons, primarily of gabbro and diorite, at 20-24 Ma, after the crust was mechanically thinned from 40 km to ??? 20 km. We infer continued spreading after that in which broad shelves were formed by a process of magmatic expansion, because the offshore crust is only 8-15 km thick, including sediment, and seismic reflection data do not depict horst and graben or half graben structures from which mechanical extension might be inferred. The Wilkes Land margin is similar to the Arabian example. The margin is about 150 km in width, the amount of upper crustal extension is too low to explain the change in sub-sediment crustal thickness from ??? 35 km on the mainland to < 10 km beneath the margin and reflectors in the deepest seismic sequence are nearly flat lying. Our model requires large volumes of melt in the early stages of continental rifting. The voluminous melt might be partly a product of nearby hot spots, such as Afar and partly the result of an initial period of partial fusion in the deep continental lithosphere under lower temperatures than ordinarily required by dry solidus conditions. ?? 1991.

Formation and evolution of magma-poor margins, an example of the West Iberia margin

NASA Astrophysics Data System (ADS)

Perez-Gussinye, Marta; Andres-Martinez, Miguel; Morgan, Jason P.; Ranero, Cesar R.; Reston, Tim

2016-04-01

The West Iberia-Newfoundland (WIM-NF) conjugate margins have been geophysically and geologically surveyed for the last 30 years and have arguably become a paradigm for magma-poor extensional margins. Here we present a coherent picture of the WIM-NF rift to drift evolution that emerges from these observations and numerical modeling, and point out important differences that may exist with other magma-poor margins world-wide. The WIM-NF is characterized by a continental crust that thins asymmetrically and a wide and symmetric continent-ocean transition (COT) interpreted to consist of exhumed and serpentinised mantle with magmatic products increasing oceanward. The architectural evolution of these margins is mainly dominated by cooling under very slow extension velocities (<~6 mm/yr half-rate) and a lower crust that most probably was not extremely weak at the start of rifting. These conditions lead to a system where initially deformation is distributed over a broad area and the upper, lower crust and lithosphere are decoupled. As extension progresses upper, lower, crust and mantle become tightly coupled and deformation localizes due to strengthening and cooling during rifting. Coupling leads to asymmetric asthenospheric uplift and weakening of the hanginwall of the active fault, where a new fault forms. This continued process leads to the formation of an array of sequential faults that dip and become younger oceanward. Here we show that these processes acting in concert: 1) reproduce the margin asymmetry observed at the WIM-NF, 2) explain the fault geometry evolution from planar, to listric to detachment like by having one common Andersonian framework, 3) lead to the symmetric exhumation of mantle with little magmatism, and 4) explain the younging of the syn-rift towards the basin centre and imply that unconformities separating syn- and post-rift may be diachronous and younger towards the ocean. Finally, we show that different lower crustal rheologies lead to different patterns of extension and to an abrupt transition to oceanic crust, even at magma-poor margins.

Color Doppler sonography and angioscintigraphy in hepatic Hodgkin’s lymphoma

PubMed Central

Stojković, Mirjana V; Artiko, Vera M; Radoman, Irena B; Knežević, Slavko J; Lukić, Snezana M; Kerkez, Mirko D; Lekić, Nebojsa S; Antić, Andrija A; Žuvela, Marinko M; Ranković, Vitomir I; Petrović, Milorad N; Šobić, Dragana P; Obradović, Vladimir B

2009-01-01

AIM: To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin’s hepatic lymphoma. METHODS: The research included patients with a diagnosis of Hodgkin’s lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index (HPI) estimated by HRA was calculated. RESULTS: In the majority of patients, hepatomegaly was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins (P > 0.05). A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r = 390, P < 0.01). HPI was significantly lower in patients with lymphomas than in controls (P < 0.05), pointing out increased arterial perfusion in comparison to portal perfusion. CONCLUSION: Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin’s hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. PMID:19598303

A framework for analyzing the impact of data integrity/quality on electricity market operations

NASA Astrophysics Data System (ADS)

Choi, Dae Hyun

This dissertation examines the impact of data integrity/quality in the supervisory control and data acquisition (SCADA) system on real-time locational marginal price (LMP) in electricity market operations. Measurement noise and/or manipulated sensor errors in a SCADA system may mislead system operators about real-time conditions in a power system, which, in turn, may impact the price signals in real-time power markets. This dissertation serves as a first attempt to analytically investigate the impact of bad/malicious data on electric power market operations. In future power system operations, which will probably involve many more sensors, the impact of sensor data integrity/quality on grid operations will become increasingly important. The first part of this dissertation studies from a market participant's perspective a new class of malicious data attacks on state estimation, which subsequently influences the result of the newly emerging look-ahead dispatch models in the real-time power market. In comparison with prior work of cyber-attack on static dispatch where no inter-temporal ramping constraint is considered, we propose a novel attack strategy, named ramp-induced data (RID) attack, with which the attacker can manipulate the limits of ramp constraints of generators in look-ahead dispatch. It is demonstrated that the proposed attack can lead to financial profits via malicious capacity withholding of selected generators, while being undetected by the existing bad data detection algorithm embedded in today's state estimation software. In the second part, we investigate from a system operator's perspective the sensitivity of locational marginal price (LMP) with respect to data corruption-induced state estimation error in real-time power market. Two data corruption scenarios are considered, in which corrupted continuous data (e.g., the power injection/flow and voltage magnitude) falsify power flow estimate whereas corrupted discrete data (e.g., the on/off status of a circuit breaker) do network topology estimate, thus leading to the distortion of LMP. We present an analytical framework to quantify real-time LMP sensitivity subject to continuous and discrete data corruption via state estimation. The proposed framework offers system operators an analytical tool to identify economically sensitive buses and transmission lines to data corruption as well as find sensors that impact LMP changes significantly. This dissertation serves as a first step towards rigorous understanding of the fundamental coupling among cyber, physical and economical layers of operations in future smart grid.

Financial Capacity Following Traumatic Brain Injury: A Six-Month Longitudinal Study

PubMed Central

Dreer, Laura E.; DeVivo, Michael J.; Novack, Thomas A.; Marson, Daniel C.

2015-01-01

Objective To longitudinally investigate financial capacity (FC) following traumatic brain injury (TBI). Design Longitudinal study comparing FC in cognitively healthy adults and persons with moderate to severe TBI at time of acute hospitalization (Time 1) and at six months post injury (Time 2). Setting Inpatient brain injury rehabilitation unit. Participants Twenty healthy adult controls and 24 adult persons with moderate to severe TBI. Main Outcome Measures Participants were administered the Financial Capacity Instrument (FCI-9), a standardized instrument that measures performance on eighteen financial tasks, nine domains, and two global scores. Between and within group differences were examined for each FCI-9 domain and global scores. Using control group referenced cut scores, participants with TBI were also assigned an impairment rating (intact, marginal, or impaired) on each domain and global score. Results At Time 1, participants with TBI performed significantly below controls on the majority of financial variables tested. At Time 2, participants with TBI demonstrated within group improvement on both simple and complex financial skills, but continued to perform below adult controls on complex financial skills and both global scores. Group by time interactions were significant for five domains and both global scores. At Time 1, high percentages of participants with TBI were assigned either ‘marginal’ or ‘impaired’ ratings on the domains and global scores, with significant percentage increases of ‘intact’ ratings at Time 2. Conclusions Immediately following acute injury, persons with moderate to severe TBI show global impairment of FC. Findings indicate improvement of both simple and complex financial skills over a six month period, but continued impairment on more complex financial skills. Future studies should examine loss and recovery of FC following TBI over longer time periods and a wider range of injury severity. PMID:22369113

Use of marginal grafts in deceased donor liver transplant: assessment of early outcomes.

PubMed

Godara, Rajesh; Naidu, C Sudeep; Rao, Pankaj P; Sharma, Sanjay; Banerjee, Jayant K; Saha, Anupam; Vijay, Kapileshwer

2014-03-01

Orthotopic liver transplantation has become a routinely applied therapy for an expanding group of patients with end-stage liver disease. Shortage of organs has led centers to expand their criteria for the acceptance of marginal donors. There is current debate about the regulation and results of liver transplantation using marginal grafts. The study included data of all patients who received deceased donor liver grafts between March 2007 to December 2011. Patients with acute liver failure, living donor transplantation, split liver transplantation, and retransplantation were excluded. Early allograft dysfunction, primary nonfunction, patient survival, and incidence of surgical complications were measured. A total of 33 patients were enrolled in this study. There were 20 marginal and 13 nonmarginal grafts. The two groups were well matched regarding age, sex and indication of liver transplantation, model for end-stage liver disease score, technique of transplant, requirement of vascular reconstruction, warm ischemia time, blood loss, mean operative time, etc. In our study, posttransplant peak level of liver enzymes, international normalization ratio, and bilirubin were not statistically significant in the marginal and nonmarginal group. Wound infection occurred in 10 % of marginal compared with 7.7 % of nonmarginal graft recipients (p > 0.05). In the marginal group, the incidences of vascular complications, hepatic artery thrombosis (four), and portal vein thrombosis (one) were not statistically significant compared to the nonmarginal group. Acute rejection was observed in a total of seven patients (21.2 %)-five (25 %) in the marginal group and two (15.4 %) in the nonmarginal graft recipients. Primary nonfunction occurred in three (9.1 %) patients-two (10 %) in the marginal and one (7.7 %) in the nonmarginal group. Average patient survival for the whole group was 91 % at 1 week, 87.8 % at 3 months, and 84.8 % at 6 months. Because organ scarcity persists, additional pressure will build to use a greater proportion of the existing donor pool. The study, although small, clearly indicates that marginal livers can assure a normal early functional recovery after transplantation.

Late Neogene and Active Tectonics along the Northern Margin of the Central Anatolian Plateau,TURKEY

NASA Astrophysics Data System (ADS)

Yildirim, C.; Schildgen, T. F.; Melnick, D.; Echtler, H. P.; Strecker, M. R.

2009-12-01

Margins of orogenic plateaus are conspicuous geomorphic provinces that archive tectonic and climatic variations related to surface uplift. Their growth is associated with spatial and temporal variations of mode and rate of tectonics and surface processes. Those processes can be strongly linked to the evolution of margins and plateaus thorough time. As one of the major morpho-tectonic provinces of Turkey, the Central Pontides (coinciding with the northern margin of the Central Anatolian Plateau (CAP)) display a remarkable topography and present valuable geologic and geomorphic indicators to identify active tectonics. Morpho-tectonic analysis, geological cross-sections, seismic profiles, and geodetic analysis reveal continuous deformation characterized by brittle faults from Late Miocene to recent across the northern margin of the CAP. In the Sinop Peninsula and offshore in the southern Black Sea, pervasive faulting and folding and uplift of Late Miocene to Quaternary marine deposits is related to active margin tectonics of the offshore southern Black Sea thrust and the onshore Balifaki and Erikli faults. In the Kastamonu-Boyabat sedimentary basin, the Late Miocene to Quaternary continental equivalents are strongly deformed by the Ekinveren Fault. This vergent inverse and thrust fault with overstepping en echelon segments deforms not only Quaternary travertines and conglomerates, but also patterns of the Pleistocene to Holocene drainage systems. In the southern Kastamonu-Boyabat basin, an antithetic thrust fault of the Ekinveren Fault system deformed also Quaternary fluviatile terrace deposits. Farther south, a dextral transpressive splay of the North Anatolian Fault (NAF) deforms pediment surfaces and forms the northern flank of the Ilgaz active mountain range. The Ilgaz Range rises up to 2587 m.a.s.l and is delimited by active segments of the NAF.The Central Pontides are located at the apex of northward convex arc of the NAF. Geodetic analysis indicate a deviation of the slip vectors and strain partitioning in the Central Pontides due to the large restraining bend geometry of the NAF. DEM analysis and field observations reveal that the Central Pontides integrate an active bivergent wedge, indicating out-of sequence thrusting and topographical asymmetry, with a gentle pro-wedge northern slope and a steep retro-wedge southern slopes, and regional surface tilting from south to north. Uplifted presumably Late Pleistocene to Holocene marine terraces 4 to 40 m.a.s.l. along the coast and well developed pediment and fill and strath terrace surfaces ranging from 10 to 300 m above along the Gokirmak and Kizilirmak rivers will provide chronological constraints on the uplift and incision rates of the study area.

Maintenance of marginal bone support and soft tissue esthetics at immediately provisionalized OsseoSpeed implants placed into extraction sites: 2-year results.

PubMed

Noelken, Robert; Neffe, Bettina Anna; Kunkel, Martin; Wagner, Wilfried

2014-02-01

Placement of implants into extraction sockets targets the maintenance of peri-implant hard and soft tissue structures and the support of a natural and esthetic contour. The main advantages of immediate implant insertion in comparison with delayed implant placement protocols are as follows: a reduced treatment time, less number of sessions, and, thus, the less invasive procedure. This study examines the clinical performance (survival rate, marginal bone levels and Pink Esthetic Score [PES]) of OsseoSpeed implants placed into extraction sockets with immediate provisionalization in the anterior maxilla after a follow-up of at least 12 months. Twenty patients received a total number of 37 OsseoSpeed implants which were immediately inserted into extraction sockets with or without facial bone deficiencies of various dimensions. A flapless procedure was applied, and the implants were immediately provisionalized with temporary crowns without occlusal contacts. Facial gaps between implant surface and facial bone or the previous contour of the alveolar process were grafted with autogenous bone chips. Implants in diameters 3.5, 4.0, 4.5, and 5.0 with lengths of 11-17 mm were used in the study. During the course of the study, interproximal marginal bone levels, the thickness of the facial bony wall, implant success rate according to the criteria established by Buser, and the PES were assessed per implant. One patient with three implants did not continue the study after prosthesis delivery, the remaining 34 implants were still in function at the final follow-up (survival rate: 100%). The mean follow-up period was 27 months (range, 12-40 months). Marginal bone height at the level of the implant shoulder averaged -0.1 ± 0.55 mm (range, -1.25 to 1.47 mm) at the final follow-up. The mean PES ratings were 11.3 ± 1.8 (range, 6-14) at the final follow-up. In 78% of the patients, the PES was preserved or even improved. Success rates, marginal bone levels, and esthetic results suggest proof of principle for the preservation of marginal bone height at immediately placed and provisionalized OsseoSpeed implants after a follow-up of at least 12 months. Even implant sites with facial bony deficiencies can be successfully treated with a favorable esthetic outcome using the immediate implant insertion, immediate reconstruction, and immediate provisionalization technique. © 2013 John Wiley & Sons A/S.

Utilization of the Organ Care System Lung for the assessment of lungs from a donor after cardiac death (DCD) before bilateral transplantation.

PubMed

Mohite, P N; Sabashnikov, A; García Sáez, D; Pates, B; Zeriouh, M; De Robertis, F; Simon, A R

2015-07-01

In this manuscript, we present the first experience of evaluating donation after circulatory death (DCD) lungs, using the normothermic preservation Organ Care System (OCS) and subsequent successful transplantation. The OCS could be a useful tool for the evaluation of marginal lungs from DCD donors as it allows a proper recruitment and bronchoscopy in such donations in addition to continuous ex-vivo perfusion and assessment and treatment during transport. The OCS could potentially be a standard of care in the evaluation of marginal lungs from DCD. © The Author(s) 2014.

Marginal inherited structures impact on the oblique convergent N American Plate/ Central Caribbean plate-boundary in the Northern Caribbean. The tectonic evolution since Miocene times based on Haiti data acquired onshore and offshore since 2012- a step toward an ADP Drilling Proposal (Haiti-DRILL).

NASA Astrophysics Data System (ADS)

Ellouz, N.; Hamon, Y.; Deschamps, R.; Battani, A.; Wessels, R.; Boisson, D.; Prepetit, C.; Momplaisir, R.

2017-12-01

Since Early Paleogene times, the North Caribbean plate is colliding obliquely with the south continental part of the old N. American Margins, which is represented by various segments from West to East, inherited from Jurassic times. Location, amount of displacement, rotation and the structural deformation of these margin segments, resulting from the dislocation of the continental N American margin, are not clearly yet established. At present, the plate limits are marked either by two left lateral faults west and inside Haiti (OSF in the North and EPGF in the South), oblique collision front (further west in Cuba), oblique subducted segments (to the East, Porto-Rico). From our recent works operated both offshore (Haiti-SIS and Haiti-BGF surveys 2012-2015) and onshore (field campaigns 2013-2017) in Haitian zone, the position of the present-day and paleo major limits have been redefined. These paleolimits have been reconstructed up to early Miocene times, based on: restoration of regional structural cross-sections, sedimentology and on paleoenvironement studies. In a preliminary way, we analyzed the complexity of the tectonic heritage with possible nature, heterogeneity of the crustal fragments and associated margins close to Haiti (age, structure, environment, location of the dislocated blocks through times) which profoundly impact the partitioning of the deformation along this complex transformed margin. The change in the structure wavelength, decollement level variations are primary constraints in the restoration of the main units and do impose a deep connection along specific segments either related to strike-slip or to splay faults. The asymmetry on the repartition of the fault activity tend to prove that the past motion related to "EPGF transfer zone" is mainly partitioned in Haiti to the North of the present-day EPGF position. At present, these results are still coherent with the distribution of the aftershoks registered after 2010, and with the present-day seismicity during the last years.

Analysis of Prostate Patient Setup and Tracking Data: Potential Intervention Strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Su Zhong, E-mail: zsu@floridaproton.org; Zhang Lisha; Murphy, Martin

Purpose: To evaluate the setup, interfraction, and intrafraction organ motion error distributions and simulate intrafraction intervention strategies for prostate radiotherapy. Methods and Materials: A total of 17 patients underwent treatment setup and were monitored using the Calypso system during radiotherapy. On average, the prostate tracking measurements were performed for 8 min/fraction for 28 fractions for each patient. For both patient couch shift data and intrafraction organ motion data, the systematic and random errors were obtained from the patient population. The planning target volume margins were calculated using the van Herk formula. Two intervention strategies were simulated using the tracking data:more » the deviation threshold and period. The related planning target volume margins, time costs, and prostate position 'fluctuation' were presented. Results: The required treatment margin for the left-right, superoinferior, and anteroposterior axes was 8.4, 10.8, and 14.7 mm for skin mark-only setup and 1.3, 2.3, and 2.8 mm using the on-line setup correction, respectively. Prostate motion significantly correlated among the superoinferior and anteroposterior directions. Of the 17 patients, 14 had prostate motion within 5 mm of the initial setup position for {>=}91.6% of the total tracking time. The treatment margin decreased to 1.1, 1.8, and 2.3 mm with a 3-mm threshold correction and to 0.5, 1.0, and 1.5 mm with an every-2-min correction in the left-right, superoinferior, and anteroposterior directions, respectively. The periodic corrections significantly increase the treatment time and increased the number of instances when the setup correction was made during transient excursions. Conclusions: The residual systematic and random error due to intrafraction prostate motion is small after on-line setup correction. Threshold-based and time-based intervention strategies both reduced the planning target volume margins. The time-based strategies increased the treatment time and the in-fraction position fluctuation.« less

Culturally Responsive Computing: A Theory Revisited

ERIC Educational Resources Information Center

Scott, Kimberly A.; Sheridan, Kimberly M.; Clark, Kevin

2015-01-01

Despite multiple efforts and considerable funding, historically marginalized groups (e.g., racial minorities and women) continue not to enter or persist in the most lucrative of fields--technology. Understanding the potency of culturally responsive teaching (CRT), some technology-enrichment programs modified CRP principles to establish a…

17 CFR 242.101 - Activities by distribution participants.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Activities by distribution participants. 242.101 Section 242.101 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES...

Time evolution of shear-induced particle margination and migration in a cellular suspension

NASA Astrophysics Data System (ADS)

Qi, Qin M.; Shaqfeh, Eric S. G.

2016-11-01

The inhomogeneous center-of-mass distributions of red blood cells and platelets normal to the flow direction in small vessels play a significant role in hemostasis and drug delivery. Under pressure-driven flow in channels, the migration of deformable red blood cells at steady state is characterized by a cell-free or Fahraeus-Lindqvist layer near the vessel wall. Rigid particles such as platelets, however, "marginate" and thus develop a near-wall excess concentration. In order to evaluate the role of branching and design suitable microfluidic devices, it is important to investigate the time evolution of particle margination and migration from a non-equilibrium state and determine the corresponding entrance lengths. From a mechanistic point of view, deformability-induced hydrodynamic lift and shear-induced diffusion are essential mechanisms for the cross-flow migration and margination. In this talk, we determine the concentration distribution of red blood cells and platelets by solving coupled Boltzmann advection-diffusion equations for both species and explore their time evolution. We verify our model by comparing with large-scale, multi-cell simulations and experiments. Our Boltzmann collision theory serves as a fast alternative to large-scale simulations.

Ensemble-marginalized Kalman filter for linear time-dependent PDEs with noisy boundary conditions: application to heat transfer in building walls

NASA Astrophysics Data System (ADS)

Iglesias, Marco; Sawlan, Zaid; Scavino, Marco; Tempone, Raúl; Wood, Christopher

2018-07-01

In this work, we present the ensemble-marginalized Kalman filter (EnMKF), a sequential algorithm analogous to our previously proposed approach (Ruggeri et al 2017 Bayesian Anal. 12 407–33, Iglesias et al 2018 Int. J. Heat Mass Transfer 116 417–31), for estimating the state and parameters of linear parabolic partial differential equations in initial-boundary value problems when the boundary data are noisy. We apply EnMKF to infer the thermal properties of building walls and to estimate the corresponding heat flux from real and synthetic data. Compared with a modified ensemble Kalman filter (EnKF) that is not marginalized, EnMKF reduces the bias error, avoids the collapse of the ensemble without needing to add inflation, and converges to the mean field posterior using or less of the ensemble size required by EnKF. According to our results, the marginalization technique in EnMKF is key to performance improvement with smaller ensembles at any fixed time.

Pennsylvanian and Early Permian paleogeography of east-central California: Implications for the shape of the continental margin and the timing of continental truncation

NASA Astrophysics Data System (ADS)

Stone, Paul; Stevens, Calvin H.

1988-04-01

Pennsylvanian and Early Permian paleogeographic features in east-central California include a southeast-trending carbonate shelf edge and turbidite basin that we infer paralleled a segment of the western margin of the North American continent. This segment of the continental margin was oblique to an adjoining segment on the north that trended southwestward across Nevada into easternmost California. We propose that the southeast-trending segment of the margin originated by tectonic truncation of the originally longer southwest-trending segment in Early or Middle Pennsylvanian to late Early Permian time, significantly earlier than a previously hypothesized Late Permian or Early Triassic continental truncation event. We interpret the truncating structure to have been a sinistral transform fault zone along which a continental fragment was removed and carried southeastward into the Caborca-Hermosillo region of northern Mexico, where it is now represented by exposures of Late Proterozoic and Paleozoic miogeoclinal rocks.

Automatic control of electric thermal storage (heat) under real-time pricing. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daryanian, B.; Tabors, R.D.; Bohn, R.E.

1995-01-01

Real-time pricing (RTP) can be used by electric utilities as a control signal for responsive demand-side management (DSM) programs. Electric thermal storage (ETS) systems in buildings provide the inherent flexibility needed to take advantage of variations in prices. Under RTP, optimal performance for ETS operations is achieved under market conditions where reductions in customers` costs coincide with the lowering of the cost of service for electric utilities. The RTP signal conveys the time-varying actual marginal cost of the electric service to customers. The RTP rate is a combination of various cost components, including marginal generation fuel and maintenance costs, marginalmore » costs of transmission and distribution losses, and marginal quality of supply and transmission costs. This report describes the results of an experiment in automatic control of heat storage systems under RTP during the winter seasons of 1989--90 and 1990--91.« less

On-Line Robust Modal Stability Prediction using Wavelet Processing

NASA Technical Reports Server (NTRS)

Brenner, Martin J.; Lind, Rick

1998-01-01

Wavelet analysis for filtering and system identification has been used to improve the estimation of aeroservoelastic stability margins. The conservatism of the robust stability margins is reduced with parametric and nonparametric time- frequency analysis of flight data in the model validation process. Nonparametric wavelet processing of data is used to reduce the effects of external disturbances and unmodeled dynamics. Parametric estimates of modal stability are also extracted using the wavelet transform. Computation of robust stability margins for stability boundary prediction depends on uncertainty descriptions derived from the data for model validation. The F-18 High Alpha Research Vehicle aeroservoelastic flight test data demonstrates improved robust stability prediction by extension of the stability boundary beyond the flight regime. Guidelines and computation times are presented to show the efficiency and practical aspects of these procedures for on-line implementation. Feasibility of the method is shown for processing flight data from time- varying nonstationary test points.

Comparison of statistical approaches dealing with time-dependent confounding in drug effectiveness studies.

PubMed

Karim, Mohammad Ehsanul; Petkau, John; Gustafson, Paul; Platt, Robert W; Tremlett, Helen

2018-06-01

In longitudinal studies, if the time-dependent covariates are affected by the past treatment, time-dependent confounding may be present. For a time-to-event response, marginal structural Cox models are frequently used to deal with such confounding. To avoid some of the problems of fitting marginal structural Cox model, the sequential Cox approach has been suggested as an alternative. Although the estimation mechanisms are different, both approaches claim to estimate the causal effect of treatment by appropriately adjusting for time-dependent confounding. We carry out simulation studies to assess the suitability of the sequential Cox approach for analyzing time-to-event data in the presence of a time-dependent covariate that may or may not be a time-dependent confounder. Results from these simulations revealed that the sequential Cox approach is not as effective as marginal structural Cox model in addressing the time-dependent confounding. The sequential Cox approach was also found to be inadequate in the presence of a time-dependent covariate. We propose a modified version of the sequential Cox approach that correctly estimates the treatment effect in both of the above scenarios. All approaches are applied to investigate the impact of beta-interferon treatment in delaying disability progression in the British Columbia Multiple Sclerosis cohort (1995-2008).

Collective plasma effects associated with the continuous injection model of solar flare particle streams

NASA Technical Reports Server (NTRS)

Vlahos, L.; Papadopoulos, K.

1979-01-01

A modified continuous injection model for impulsive solar flares that includes self-consistent plasma nonlinearities based on the concept of marginal stability is presented. A quasi-stationary state is established, composed of a hot truncated electron Maxwellian distribution confined by acoustic turbulence on the top of the loop and energetic electron beams precipitating in the chromosphere. It is shown that the radiation properties of the model are in accordance with observations.

Collagen Sponge Functionalized with Chimeric Anti-BMP-2 Monoclonal Antibody Mediates Repair of Critical-Size Mandibular Continuity Defects in a Nonhuman Primate Model

PubMed Central

Xie, Yilin; Su, Yingying; Tang, Jianxia; Goh, Bee Tin; Saigo, Leonardo; Zhang, Chunmei; Wang, Jinsong; Khojasteh, Arash; Wang, Songlin

2017-01-01

Antibody-mediated osseous regeneration (AMOR) has been introduced by our research group as a tissue engineering approach to capture of endogenous growth factors through the application of specific monoclonal antibodies (mAbs) immobilized on a scaffold. Specifically, anti-Bone Morphogenetic Protein- (BMP-) 2 mAbs have been demonstrated to be efficacious in mediating bone repair in a number of bone defects. The present study sought to investigate the application of AMOR for repair of mandibular continuity defect in nonhuman primates. Critical-sized mandibular continuity defects were created in Macaca fascicularis locally implanted with absorbable collagen sponges (ACS) functionalized with chimeric anti-BMP-2 mAb or isotype control mAb. 2D and 3D analysis of cone beam computed tomography (CBCT) imaging demonstrated increased bone density and volume observed within mandibular continuity defects implanted with collagen scaffolds functionalized with anti-BMP-2 mAb, compared with isotype-matched control mAb. Both CBCT imaging and histologic examination demonstrated de novo bone formation that was in direct apposition to the margins of the resected bone. It is hypothesized that bone injury may be necessary for AMOR. This is evidenced by de novo bone formation adjacent to resected bone margins, which may be the source of endogenous BMPs captured by anti-BMP-2 mAb, in turn mediating bone repair. PMID:28401163

Asymptotic Linearity of Optimal Control Modification Adaptive Law with Analytical Stability Margins

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.

2010-01-01

Optimal control modification has been developed to improve robustness to model-reference adaptive control. For systems with linear matched uncertainty, optimal control modification adaptive law can be shown by a singular perturbation argument to possess an outer solution that exhibits a linear asymptotic property. Analytical expressions of phase and time delay margins for the outer solution can be obtained. Using the gradient projection operator, a free design parameter of the adaptive law can be selected to satisfy stability margins.

The Balanced Budget Act of 1997 and the financial health of teaching hospitals.

PubMed

Phillips, Robert L; Fryer, George E; Chen, Frederick M; Morgan, Sarah E; Green, Larry A; Valente, Ernest; Miyoshi, Thomas J

2004-01-01

We wanted to evaluate the most recent, complete data related to the specific effects of the Balanced Budget Act of 1997 relative to the overall financial health of teaching hospitals. We also define cost report variables and calculations necessary for continued impact monitoring. We undertook a descriptive analysis of hospital cost report variables for 1996, 1998, and 1999, using simple calculations of total, Medicare, prospective payment system, graduate medical education (GME), and bad debt margins, as well as the proportion with negative total operating margins. Nearly 35% of teaching hospitals had negative operating margins in 1999. Teaching hospital total margins fell by nearly 50% between 1996 and 1999, while Medicare margins remained relatively stable. GME margins have fallen by nearly 24%, however, even as reported education costs have risen by nearly 12%. Medicare + Choice GME payments were less than 10% of those projected. Teaching hospitals realized deep cuts in profitability between 1996 and 1999; however, these cuts were not entirely attributable to the Balanced Budget Act of 1997. Medicare payments remain an important financial cushion for teaching hospitals, more than one third of which operated in the red. The role of Medicare in supporting GME has been substantially reduced and needs special attention in the overall debate. Medicare + Choice support of the medical education enterprise is 90% less than baseline projections and should be thoroughly investigated. The Medicare Payment Advisory Commission, which has a critical role in evaluating the effects of Medicare policy changes, should be more transparent in its methods.

Seismic imaging of Late Cretaceous magmatic system in the northern margin of South China Sea

NASA Astrophysics Data System (ADS)

Xia, S.; Xu, H.; Sun, J.; Zhao, F.; Fan, C.

2017-12-01

The origin and evolution of magmatism in the rifting margins are the fundamentally geological subjects, and remain the focus of intense study. Different from the classical volcanic or nonvolcanic rifting margins, the northern margin of South China Sea (SCS) experienced uniquely regional tectonic processes, and formed plentiful intraplate seamounts mainly at the postrift period. There is considerable controversy over what caused the intensively postrift intraplate volcanism. Here we combine a new crustal structure with previously systematic petrologic and seismic tomographic results to first provide importantly new insights into a mantle plume origin and complex multilevel plumbing system of intraplate seamounts in the northern margin of SCS. Large amounts of active melts from the lower mantle migrated upward and reached the base of the lithosphere. The volatile-rich and overheated magmas continued ascending along the weak zone through the lithosphere and intruded into the lower crust. The intrusion magmas then ascended forward along the faults formed during the rifting, and supplied the magma source for the formation of intraplate seamounts in the northern margin of SCS. It supplies an important implication for the volume and range of late Cenozoic basaltic magmatism deriving from the Hainan mantle plume. Keywords: South China Sea; Late Cretaceous; Magmatic System; Hainan Plume AcknowledgementsThe field work of this study was assisted by the captain and crew of the R/V Shiyan 2. Prof. Xuelin Qiu supplied great helps for the successful implementation of the cruise. This work was partially supported by grants from the National Natural Science Foundation of China (Grant Nos. 91328206 and 41576041).

The Dauki Thrust Fault and the Shillong Anticline: An incipient plate boundary in NE India?

NASA Astrophysics Data System (ADS)

Ferguson, E. K.; Seeber, L.; Steckler, M. S.; Akhter, S. H.; Mondal, D.; Lenhart, A.

2012-12-01

The Shillong Massif is a regional contractional structure developing across the Assam sliver of the Indian plate near the Eastern Syntaxis between the Himalaya and Burma arcs. Faulting associated with the Shillong Massif is a major source of earthquake hazard. The massif is a composite basement-cored asymmetric anticline and is 100km wide, >350km long and 1.8km high. The high relief southern limb preserves a Cretaceous-Paleocene passive margin sequence despite extreme rainfall while the gentler northern limb is devoid of sedimentary cover. This asymmetry suggests southward growth of the structure. The Dauki fault along the south limb builds this relief. From the south-verging structure, we infer a regional deeply-rooted north-dipping blind thrust fault. It strikes E-W and obliquely intersects the NE-SW margin of India, thus displaying three segments: Western, within continental India; Central, along the former passive margin; and Eastern, overridden by the west-verging Burma accretion system. We present findings from recent geologic fieldwork on the western and central segments. The broadly warped erosional surface of the massif defines a single anticline in the central segment, east of the intersection with the hinge zone of the continental margin buried by the Ganges-Brahmaputra Delta. The south limb of the anticline forms a steep topographic front, but is even steeper structurally as defined by the Cretaceous-Eocene cover. Below it, Sylhet Trap Basalts intrude and cover Precambrian basement. Dikes, presumably parallel to the rifted margin, are also parallel to the front, suggesting thrust reactivation of rift-related faults. Less competent Neogene clastics are preserved only near the base of the mountain front. Drag folds in these rocks suggest north-vergence and a roof thrust above a blind thrust wedge floored by the Dauki thrust fault. West of the hinge zone, the contractional structure penetrates the Indian continent and bifurcates. After branching into the Dapsi Fault, the Dauki Fault continues westward as the erosion-deposition boundary combined with a belt of N-S shortening. The Dapsi thrust fault strikes WNW across the Shillong massif and dips NNE. It is mostly blind below a topographically expressed fold involving basement and passive-margin cover. Recent fieldwork has shown that the fault is better exposed in the west, where eventually Archean basement juxtaposes folded and steeply dipping fluvial sediment. Both Dauki and Dapsi faults probably continue beyond the Brahmaputra River, where extreme fluvial processes mask them. The area between the two faults is a gentle southward monocline with little or no shortening. Thus uplift of this area stems from slip on the Dauki thrust fault, not from pervasive shortening. The Burma foldbelt overrides the Shillong Plateau and is warped but continuous across the eastern segment of the Dauki fault. The Haflong-Naga thrust front north of the Dauki merges with the fold-thrust belt in the Sylhet basin to the south, despite >150km of differential advance due to much greater advance of the accretionary prism in the basin. Where the Dauki and Haflong-Naga thrusts cross, the thrust fronts are nearly parallel and opposite vergence. We trace a Dauki-related topographic front eastward across the Burma Range. This and other evidence suggest that the Dauki Fault continues below the foldbelt.

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin

NASA Astrophysics Data System (ADS)

van Hengstum, Peter J.; Donnelly, Jeffrey P.; Fall, Patricia L.; Toomey, Michael R.; Albury, Nancy A.; Kakuk, Brian

2016-02-01

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin

PubMed Central

van Hengstum, Peter J.; Donnelly, Jeffrey P.; Fall, Patricia L.; Toomey, Michael R.; Albury, Nancy A.; Kakuk, Brian

2016-01-01

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval. PMID:26906670

Marginalized Student Access to Technology Education

NASA Astrophysics Data System (ADS)

Kurtcu, Wanda M.

The purpose of this paper is to investigate how a teacher can disrupt an established curriculum that continues the cycle of inequity of access to science, technology, engineering, and math (STEM) curriculum by students in alternative education. For this paper, I will focus on the technology components of the STEM curriculum. Technology in the United States, if not the world economy, is developing at a rapid pace. Many areas of day to day living, from applying for a job to checking one's bank account online, involve a component of science and technology. The 'gap' in technology education is emphasized between the 'haves and have-nots', which is delineated along socio-economic lines. Marginalized students in alternative education programs use this equipment for little else than remedial programs and credit recovery. This level of inequity further widens in alternative education programs and affects the achievement of marginalized students in credit recovery or alternative education classes instead of participation technology classes. For the purposes of this paper I focus on how can I decrease the inequity of student access to 21st century technology education in an alternative education program by addressing the established curriculum of the program and modifying structural barriers of marginalized student access to a technology focused curriculum.

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin

USGS Publications Warehouse

van Hengstrum, Peter J.; Donnelly, Jeffrey P.; Fall, Patricia L.; Toomey, Michael; Albury, Nancy A.; Kakuk, Brian

2016-01-01

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin.

PubMed

van Hengstum, Peter J; Donnelly, Jeffrey P; Fall, Patricia L; Toomey, Michael R; Albury, Nancy A; Kakuk, Brian

2016-02-24

Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm records are needed from multiple sites to assess this hypothesis. Here we present a 3000 year record of intense hurricane strikes in the northern Bahamas (Abaco Island) based on overwash deposits in a coastal sinkhole, which indicates that the ITCZ has likely helped modulate intense hurricane strikes on the western North Atlantic margin on millennial to centennial-scales. The new reconstruction closely matches a previous reconstruction from Puerto Rico, and documents a period of elevated intense hurricane activity on the western North Atlantic margin from 2500 to 1000 years ago when paleo precipitation proxies suggest that the ITCZ occupied a more northern position. Considering that anthropogenic warming is predicted to be focused in the northern hemisphere in the coming century, these results provide a prehistoric analog that an attendant northern ITCZ shift in the future may again return the western North Atlantic margin to an active hurricane interval.

Meta-Analysis of Correlations Between Marginal Bone Resorption and High Insertion Torque of Dental Implants.

PubMed

Li, Haoyan; Liang, Yongqiang; Zheng, Qiang

2015-01-01

To evaluate correlations between marginal bone resorption and high insertion torque value (> 50 Ncm) of dental implants and to assess the significance of immediate and early/conventional loading of implants under a certain range torque value. Specific inclusion and exclusion criteria were used to retrieve eligible articles from Ovid, PubMed, and EBSCO up to December 2013. Screening of eligible studies, quality assessment, and data extraction were conducted in duplicate. The results were expressed as random/fixed-effects models using weighted mean differences for continuous outcomes with 95% confidence intervals. Initially, 154 articles were selected (11 from Ovid, 112 from PubMed, and 31 from EBSCO). After exclusion of duplicate articles and articles that did not meet the inclusion criteria, six clinical studies were selected. Assessment of P values revealed that correlations between marginal bone resorption and high insertion torque were not statistically significant and that there was no difference between immediately versus early/conventionally loaded implants under a certain range of torque. None of the meta-analyses revealed any statistically significant differences between high insertion torque and conventional insertion torque in terms of effects on marginal bone resorption.

Paleozoic and mesozoic evolution of East-Central California

USGS Publications Warehouse

Stevens, C.H.; Stone, P.; Dunne, G.C.; Greene, D.C.; Walker, J.D.; Swanson, B.J.

1997-01-01

East-central California, which encompasses an area located on the westernmost part of sialic North America, contains a well-preserved record of Paleozoic and Mesozoic tectonic events that reflect the evolving nature of the Cordilleran plate margin to the west. After the plate margin was formed by continental rifting in the Neoproterozoic, sediments comprising the Cordilleran miogeocline began to accumulate on the subsiding passive margin. In east-central California, sedimentation did not keep pace with subsidence, resulting in backstepping of a series of successive carbonate platforms throughout the early and middle Paleozoic. This phase of miogeoclinal development was brought to a close by the Late Devonian-Early Mississippian Antler orogeny, during the final phase of which oceanic rocks were emplaced onto the continental margin. Subsequent Late Mississippian-Pennsylvanian faulting and apparent reorientation of the carbonate platform margin are interpreted to have been associated with truncation of the continental plate on a sinistral transform fault zone. In the Early Permian, contractional deformation in east-central California led to the development of a narrow, uplifted thrust belt flanked by marine basins in which thick sequences of deep-water strata accumulated. A second episode of contractional deformation in late Early Permian to earliest Triassic time widened and further uplifted the thrust belt and produced the recently identified Inyo Crest thrust, which here is correlated with the regionally significant Last Chance thrust. In the Late Permian, about the time of the second contractional episode, extensional faulting created shallow sedimentary basins in the southern Inyo Mountains. In the El Paso Mountains to the south, deformation and plutonism record the onset of subduction and arc magmatism in late Early Permian to earliest Triassic time along this part of the margin. Tectonism had ceased in most of east-central California by middle to late Early Triassic time, and marine sediment deposited on the subsiding continental shelf overlapped the previously deformed Permian rocks. Renewed contractional deformation, probably in the Middle Triassic, is interpreted to be associated with emplacement of the Golconda allochthon onto the margin of the continent. This event, which is identified with certainty in the Sierra Nevada, also may have significantly affected rocks in the White and Inyo Mountains to the east. Subduction and arc magmatism that created most of the Sierra Nevada batholith began in the Late Triassic and lasted through the remainder of the Mesozoic. During this time, the East Sierran thrust system (ESTS) developed as a narrow zone of intense, predominantly E-vergent contractional deformation along the eastern margin of the growing batholith. Activity on the ESTS took place over an extended part of Mesozoic time, both before and after intrusion of voluminous Middle Jurassic plutons, and is interpreted to have been mechanically linked to emplacement of the batholith. Deformation on the ESTS and magmatism in the Sierra Nevada both ended prior to the close of the Cretaceous.

Time-Variable Transit Time Distributions in the Hyporheic Zone of a Headwater Mountain Stream

NASA Astrophysics Data System (ADS)

Ward, Adam S.; Schmadel, Noah M.; Wondzell, Steven M.

2018-03-01

Exchange of water between streams and their hyporheic zones is known to be dynamic in response to hydrologic forcing, variable in space, and to exist in a framework with nested flow cells. The expected result of heterogeneous geomorphic setting, hydrologic forcing, and between-feature interaction is hyporheic transit times that are highly variable in both space and time. Transit time distributions (TTDs) are important as they reflect the potential for hyporheic processes to impact biogeochemical transformations and ecosystems. In this study we simulate time-variable transit time distributions based on dynamic vertical exchange in a headwater mountain stream with observed, heterogeneous step-pool morphology. Our simulations include hyporheic exchange over a 600 m river corridor reach driven by continuously observed, time-variable hydrologic conditions for more than 1 year. We found that spatial variability at an instance in time is typically larger than temporal variation for the reach. Furthermore, we found reach-scale TTDs were marginally variable under all but the most extreme hydrologic conditions, indicating that TTDs are highly transferable in time. Finally, we found that aggregation of annual variation in space and time into a "master TTD" reasonably represents most of the hydrologic dynamics simulated, suggesting that this aggregation approach may provide a relevant basis for scaling from features or short reaches to entire networks.

Intraoperative monitoring of marginal mandibular nerve during neck dissection.

PubMed

Tirelli, Giancarlo; Bergamini, Pier Riccardo; Scardoni, Alessandro; Gatto, Annalisa; Boscolo Nata, Francesca; Marcuzzo, Alberto Vito

2018-05-01

The purpose of this study was to assess the efficacy of intraoperative nerve integrity monitoring (NIM) to prevent marginal mandibular nerve injuries during neck dissection. This prospective study compared 36 patients undergoing NIM-assisted neck dissection from July 2014 to March 2015 to a cohort of 35 patients subjected to neck dissection over an identical period of time before the technique was introduced. We also assessed possible correlations between marginal mandibular nerve injuries and other factors, such as anthropometric measurements, presence of clinical neck metastases, type of neck dissection, and site of primary tumor. The incidence of marginal mandibular nerve paralyses was significantly lower among the group of patients undergoing NIM-assisted neck dissection (P = .021). There was no significant difference in the duration of the procedure, and the technique resulted in a limited increase of cost. No other factor seemed to influence the onset of marginal mandibular nerve palsy. In our opinion, NIM is a valuable aid for preventing marginal mandibular nerve injuries during neck dissection. © 2018 Wiley Periodicals, Inc.

Little Ice Age Fluctuations of Quelccaya Ice Cap, Peru

NASA Astrophysics Data System (ADS)

Stroup, J. S.; Kelly, M. A.; Lowell, T.

2009-12-01

A record of the past extents of Quelccaya Ice Cap (QIC) provides valuable information about tropical climate change from late glacial to recent time. Here, we examine the timing and regional significance of fluctuations of QIC during the Little Ice Age (LIA; ~1300-1850 AD). One prominent set of moraines, known as the Huancane I moraines, is located ~1 km from the present-day western ice cap margin and provides a near-continuous outline of the most recent advance of QIC. This moraine set was radiocarbon dated (~298 ± 134 and 831 ± 87 yr BP) by Mercer and Palacios (1977) and presented as some of the first evidence for cooling in the tropics during the Little Ice Age. Recent field investigations in the QIC region focused on refining the chronology of the Huancane I moraines. In 2008, new stratigraphic sections exposed by local lake-flooding events revealed multiple layers of peat within the Huancane I moraines. In both 2008 and 2009, samples were obtained for 10Be dating of boulders on Huancane I moraines. A combination of radiocarbon and 10Be ages indicate that the Huancane I moraines were deposited by ice cap expansion after ~3800 yr BP and likely by multiple advances at approximately 1000, 600, 400, and 200 yr BP. Radiocarbon and 10Be chronologies of the Huancane I moraines are compared with the Quelccaya ice core records (Thompson et al., 1985; 1986; 2006). Accumulation data from the ice core records are interpreted to indicate a significant wet period at ~1500-1700 AD followed by a significant drought at ~1720-1860 AD. We examine ice marginal fluctuations during these times to determine influence of such events on the ice cap extent.

Evolution of the continental margin of southern Spain and the Alboran Sea

USGS Publications Warehouse

Dillon, William P.; Robb, James M.; Greene, H. Gary; Lucena, Juan Carlos

1980-01-01

Seismic reflection profiles and magnetic intensity measurements were collected across the southern continental margin of Spain and the Alboran basin between Spain and Africa. Correlation of the distinct seismic stratigraphy observed in the profiles to stratigraphic information obtained from cores at Deep Sea Drilling Project site 121 allows effective dating of tectonic events. The Alboran Sea basin occupies a zone of motion between the African and Iberian lithospheric plates that probably began to form by extension in late Miocene time (Tortonian). At the end of Miocene time (end of Messinian) profiles show that an angular unconformity was cut, and then the strata were block faulted before subsequent deposition. The erosion of the unconformity probably resulted from lowering of Mediterranean sea level by evaporation when the previous channel between the Mediterranean and Atlantic was closed. Continued extension probably caused the block faulting and, eventually the opening of the present channel to the Atlantic through the Strait of Gibraltar and the reflooding of the Mediterranean. Minor tectonic movements at the end of Calabrian time (early Pleistocene) apparently resulted in minor faulting, extensive transgression in southeastern Spain, and major changes in the sedimentary environment of the Alboran basin. Active faulting observed at five locations on seismic profiles seems to form a NNE zone of transcurrent movement across the Alboran Sea. This inferred fault trend is coincident with some bathymetric, magnetic and seismicity trends and colinear with active faults that have been mapped on-shore in Morocco and Spain. The faults were probably caused by stresses related to plate movements, and their direction was modified by inherited fractures in the lithosphere that floors the Alboran Sea.

Role of specimen US for predicting resection margin status in breast conserving therapy

PubMed Central

MOSCHETTA, M.; TELEGRAFO, M.; INTRONA, T.; COI, L.; RELLA, L.; RANIERI, V.; CIRILLI, A.; IANORA, A.A. STABILE; ANGELELLI, G.

2015-01-01

Aim To assess the diagnostic accuracy of specimen ultrasound (US) for predicting resection margin status in women undergoing breast conserving therapy for US-detected cancer, having the histological findings as the reference standard. Patients and methods A total of 132 consecutive patients (age range, 34–87 years; mean, 51 years) underwent breast-conserving surgery for US-detected invasive breast cancer. All surgical specimens underwent US examination. The presence of lesion within the specimen and its distance from the specimen margins were assessed considering a threshold distance between the lesion and specimen margins of 10 mm. US findings were then compared with the pathological ones and specimen US. Sensitivity, specificity, diagnostic accuracy, positive (PPV) and negative predictive values (NPV) for predicting histological margin status were evaluated, having the histological findings as the reference standard. Results The histological examination detected invasive ductal carcinoma in 96/132 (73%) cases, invasive lobular carcinoma in 32/132 (24%), mucinous carcinoma in 4/132 (3%). The pathological margin analysis revealed 96/132 (73%) negative margins and 36 (27%) close/positive margins. US examination detected all 132 breast lesions within the surgical specimens. 110 (83%) negative margins and 22 (17%) positive margins were found on US. Sensitivity, specificity, diagnostic accuracy, PPV and NPV of 44%, 94%, 80%, 73% and 82%, respectively, were found for specimen US. Conclusions Specimen US represents a time and cost saving imaging tool for evaluating the presence of US detected-breast lesion within surgical specimen and for predicting the histological margin status. PMID:26712255

Surgeon contribution to hospital bottom line: not all are created equal.

PubMed

Resnick, Andrew S; Corrigan, Diane; Mullen, James L; Kaiser, Larry R

2005-10-01

We hypothesized that surgeon productivity is directly related to hospital operating margin, but significant variation in margin contribution exists between specialties. As the independent practitioner becomes an endangered species, it is critical to better understand the surgeon's importance to a hospital's bottom line. An appreciation of surgeon contribution to hospital profitability may prove useful in negotiations relating to full-time employment or other models. Surgeon total relative value units (RVUs), a measure of productivity, were collected from operating room (OR) logs. Annual hospital margin per specialty was provided by hospital finance. Hospital margin data were normalized by dividing by a constant such that the highest relative hospital margin (RHM) in fiscal year 2004 expressed as margin units (mu) was 1 million mu. For each specialty, data analyzed included RHM/OR HR, RHM/case, and RHM/RVU. Thoracic (34.55 mu/RVU) and transplant (25.13 mu/RVU) were the biggest contributors to hospital margin. Plastics (-0.57 mu/RVU), maxillofacial (1.41 mu/RVU), and gynecology (1.66 mu/RVU) contributed least to hospital margin. Relative hospital margin per OR HR for transplant slightly exceeded thoracic (275.74 mu vs 233.94 mu) at the top and plastics and maxillofacial contributed the least (-3.83 mu/OR HR vs 9.36 mu/OR HR). Surgeons contribute significantly to hospital margin with certain specialties being more profitable than others. Payer mix, the penetration of managed care, and negotiated contracts as well as a number of other factors all have an impact on an individual hospital's margin. Surgeons should be fully cognizant of their significant influence in the marketplace.

Positive Margins by Oropharyngeal Subsite in Transoral Robotic Surgery for T1/T2 Squamous Cell Carcinoma.

PubMed

Persky, Michael J; Albergotti, William G; Rath, Tanya J; Kubik, Mark W; Abberbock, Shira; Geltzeiler, Mathew; Kim, Seungwon; Duvvuri, Umamaheswar; Ferris, Robert L

2018-04-01

Objective To compare positive margin rates between the 2 most common subsites of oropharyngeal transoral robotic surgery (TORS), the base of tongue (BOT) and the tonsil, as well as identify preoperative imaging characteristics that predispose toward positive margins. Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods We compared the final and intraoperative positive margin rate between TORS resections for tonsil and BOT oropharyngeal squamous cell carcinoma (OPSCC), as well as the effect of margins on treatment. A blinded neuroradiologist examined the preoperative imaging of BOT tumors to measure their dimensions and patterns of spread and provided a prediction of final margin results. Results Between January 2010 and May 2016, a total of 254 patients underwent TORS for OPSCC. A total of 140 patients who underwent TORS for T1/T2 OPSCC met inclusion criteria. A final positive margin is significantly more likely for BOT tumors than tonsil tumors (19.6% vs 4.5%, respectively, P = .004) and likewise for intraoperative margins of BOT and tonsil tumors (35.3% vs 12.4%, respectively; P = .002). A positive final margin is 10 times more likely to receive chemoradiation compared to a negative margin, controlling for extracapsular spread and nodal status (odds ratio, 9.6; 95% confidence interval, 1.6-59.6; P = .02). Preoperative imaging characteristics and subjective radiologic examination of BOT tumors did not correlate with final margin status. Conclusion Positive margins are significantly more likely during TORS BOT resections compared to tonsil resections. More research is needed to help surgeons predict which T1/T2 tumors will be difficult to completely extirpate.

Nonlinear times series analysis of epileptic human electroencephalogram (EEG)

NASA Astrophysics Data System (ADS)

Li, Dingzhou

The problem of seizure anticipation in patients with epilepsy has attracted significant attention in the past few years. In this paper we discuss two approaches, using methods of nonlinear time series analysis applied to scalp electrode recordings, which is able to distinguish between epochs temporally distant from and just prior to, the onset of a seizure in patients with temporal lobe epilepsy. First we describe a method involving a comparison of recordings taken from electrodes adjacent to and remote from the site of the seizure focus. In particular, we define a nonlinear quantity which we call marginal predictability. This quantity is computed using data from remote and from adjacent electrodes. We find that the difference between the marginal predictabilities computed for the remote and adjacent electrodes decreases several tens of minutes prior to seizure onset, compared to its value interictally. We also show that these difl'crcnc es of marginal predictability intervals are independent of the behavior state of the patient. Next we examine the please coherence between different electrodes both in the long-range and the short-range. When time is distant from seizure onsets ("interictally"), epileptic patients have lower long-range phase coherence in the delta (1-4Hz) and beta (18-30Hz) frequency band compared to nonepileptic subjects. When seizures approach (''preictally"), we observe an increase in phase coherence in the beta band. However, interictally there is no difference in short-range phase coherence between this cohort of patients and non-epileptic subjects. Preictally short-range phase coherence also increases in the alpha (10-13Hz) and the beta band. Next we apply the quantity marginal predictability on the phase difference time series. Such marginal predictabilities are lower in the patients than in the non-epileptic subjects. However, when seizure approaches, the former moves asymptotically towards the latter.

Active contour configuration model for estimating the posterior ablative margin in image fusion of real-time ultrasound and 3D ultrasound or magnetic resonance images for radiofrequency ablation: an experimental study.

PubMed

Lee, Junkyo; Lee, Min Woo; Choi, Dongil; Cha, Dong Ik; Lee, Sunyoung; Kang, Tae Wook; Yang, Jehoon; Jo, Jaemoon; Bang, Won-Chul; Kim, Jongsik; Shin, Dongkuk

2017-12-21

The purpose of this study was to evaluate the accuracy of an active contour model for estimating the posterior ablative margin in images obtained by the fusion of real-time ultrasonography (US) and 3-dimensional (3D) US or magnetic resonance (MR) images of an experimental tumor model for radiofrequency ablation. Chickpeas (n=12) and bovine rump meat (n=12) were used as an experimental tumor model. Grayscale 3D US and T1-weighted MR images were pre-acquired for use as reference datasets. US and MR/3D US fusion was performed for one group (n=4), and US and 3D US fusion only (n=8) was performed for the other group. Half of the models in each group were completely ablated, while the other half were incompletely ablated. Hyperechoic ablation areas were extracted using an active contour model from real-time US images, and the posterior margin of the ablation zone was estimated from the anterior margin. After the experiments, the ablated pieces of bovine rump meat were cut along the electrode path and the cut planes were photographed. The US images with the estimated posterior margin were compared with the photographs and post-ablation MR images. The extracted contours of the ablation zones from 12 US fusion videos and post-ablation MR images were also matched. In the four models fused under real-time US with MR/3D US, compression from the transducer and the insertion of an electrode resulted in misregistration between the real-time US and MR images, making the estimation of the ablation zones less accurate than was achieved through fusion between real-time US and 3D US. Eight of the 12 post-ablation 3D US images were graded as good when compared with the sectioned specimens, and 10 of the 12 were graded as good in a comparison with nicotinamide adenine dinucleotide staining and histopathologic results. Estimating the posterior ablative margin using an active contour model is a feasible way of predicting the ablation area, and US/3D US fusion was more accurate than US/MR fusion.

Wavelet Filtering to Reduce Conservatism in Aeroservoelastic Robust Stability Margins

NASA Technical Reports Server (NTRS)

Brenner, Marty; Lind, Rick

1998-01-01

Wavelet analysis for filtering and system identification was used to improve the estimation of aeroservoelastic stability margins. The conservatism of the robust stability margins was reduced with parametric and nonparametric time-frequency analysis of flight data in the model validation process. Nonparametric wavelet processing of data was used to reduce the effects of external desirableness and unmodeled dynamics. Parametric estimates of modal stability were also extracted using the wavelet transform. Computation of robust stability margins for stability boundary prediction depends on uncertainty descriptions derived from the data for model validation. F-18 high Alpha Research Vehicle aeroservoelastic flight test data demonstrated improved robust stability prediction by extension of the stability boundary beyond the flight regime.

ACHP | News | Legislation Passes Senate

Science.gov Websites

Search skip specific nav links Home arrow News arrow Legislation Passes Senate Secretary Kempthorne continue historic preservation programs founded by each of the past two First Ladies in legislation passed Hillary Clinton. "Bipartisan approval of this legislation by an overwhelming margin reflects the

17 CFR 242.607 - Customer account statements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Customer account statements... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation Nms-Regulation of the National Market System § 242.607 Customer account statements. (a) No broker...

Glysphosate-resistant Palmer amaranth (Amaranthus palmeri) morphology,growth, and seed production in Georgia

USDA-ARS?s Scientific Manuscript database

Herbicide resistant Palmer amaranth has become the most economically detrimental weed of cotton in the Southeast US. With the continual marginalization of potential herbicide tools, research has expanded to include alternative means of affecting future Palmer amaranth populations by altering safe s...

Glyphosate-resistant Palmer amaranth (Amaranthus palmeri) morphology, growth, and seed production in Georgia

USDA-ARS?s Scientific Manuscript database

Herbicide resistant Palmer amaranth has become the most economically detrimental weed of cotton in the Southeast US. With the continual marginalization of potential herbicide tools, research has expanded to include alternative means of affecting future Palmer amaranth populations by altering safe s...

Contractors are cautiously optimistic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stremel, K.

1984-10-01

Anticipating stable crew counts and marginal increases in operator exploration budgets, geophysical contractors are cautiously optimistic about continued industry growth. Most companies are operating on lean profits, and more business consolidations are expected as the market gradually rebounds. Prospects for an upturn in geophysical operations by oil companies are discussed.

A Strategic Racial Equity Framework

ERIC Educational Resources Information Center

Garces, Liliana M.; Gordon da Cruz, Cynthia

2017-01-01

Despite the achievement of key civil rights milestones, as well as growing public awareness and concern, educational inequities for students of color and other historically marginalized students continue to persist throughout the U.S. educational system (Aud, Fox, & KewalRamani, 2010). The pursuit of educational equity has often been achieved…

17 CFR 242.301 - Requirements for alternative trading systems.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Requirements for alternative trading systems. 242.301 Section 242.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY...

17 CFR 242.301 - Requirements for alternative trading systems.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Requirements for alternative trading systems. 242.301 Section 242.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY...

17 CFR 242.301 - Requirements for alternative trading systems.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Requirements for alternative trading systems. 242.301 Section 242.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY...

17 CFR 242.301 - Requirements for alternative trading systems.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Requirements for alternative trading systems. 242.301 Section 242.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY...

RESEARCH PROJECT A: MAPPING DISPARITIES IN BIRTH OUTCOMES

EPA Science Inventory

Turbidite event history--Methods and implications for Holocene paleoseismicity of the Cascadia subduction zone

USGS Publications Warehouse

Goldfinger, Chris; Nelson, C. Hans; Morey, Ann E.; Johnson, Joel E.; Patton, Jason R.; Karabanov, Eugene B.; Gutierrez-Pastor, Julia; Eriksson, Andrew T.; Gracia, Eulalia; Dunhill, Gita; Enkin, Randolph J.; Dallimore, Audrey; Vallier, Tracy; Kayen, Robert; Kayen, Robert

2012-01-01

Turbidite systems along the continental margin of Cascadia Basin from Vancouver Island, Canada, to Cape Mendocino, California, United States, have been investigated with swath bathymetry; newly collected and archive piston, gravity, kasten, and box cores; and accelerator mass spectrometry radiocarbon dates. The purpose of this study is to test the applicability of the Holocene turbidite record as a paleoseismic record for the Cascadia subduction zone. The Cascadia Basin is an ideal place to develop a turbidite paleoseismologic method and to record paleoearthquakes because (1) a single subduction-zone fault underlies the Cascadia submarine-canyon systems; (2) multiple tributary canyons and a variety of turbidite systems and sedimentary sources exist to use in tests of synchronous turbidite triggering; (3) the Cascadia trench is completely sediment filled, allowing channel systems to trend seaward across the abyssal plain, rather than merging in the trench; (4) the continental shelf is wide, favoring disconnection of Holocene river systems from their largely Pleistocene canyons; and (5) excellent stratigraphic datums, including the Mazama ash and distinguishable sedimentological and faunal changes near the Pleistocene-Holocene boundary, are present for correlating events and anchoring the temporal framework. Multiple tributaries to Cascadia Channel with 50- to 150-km spacing, and a wide variety of other turbidite systems with different sedimentary sources contain 13 post-Mazama-ash and 19 Holocene turbidites. Likely correlative sequences are found in Cascadia Channel, Juan de Fuca Channel off Washington, and Hydrate Ridge slope basin and Astoria Fan off northern and central Oregon. A probable correlative sequence of turbidites is also found in cores on Rogue Apron off southern Oregon. The Hydrate Ridge and Rogue Apron cores also include 12-22 interspersed thinner turbidite beds respectively. We use 14C dates, relative-dating tests at channel confluences, and stratigraphic correlation of turbidites to determine whether turbidites deposited in separate channel systems are correlative - triggered by a common event. In most cases, these tests can separate earthquake-triggered turbidity currents from other possible sources. The 10,000-year turbidite record along the Cascadia margin passes several tests for synchronous triggering and correlates well with the shorter onshore paleoseismic record. The synchroneity of a 10,000-year turbidite-event record for 500 km along the northern half of the Cascadia subduction zone is best explained by paleoseismic triggering by great earthquakes. Similarly, we find a likely synchronous record in southern Cascadia, including correlated additional events along the southern margin. We examine the applicability of other regional triggers, such as storm waves, storm surges, hyperpycnal flows, and teletsunami, specifically for the Cascadia margin. The average age of the oldest turbidite emplacement event in the 10-0-ka series is 9,800±~210 cal yr B.P. and the youngest is 270±~120 cal yr B.P., indistinguishable from the A.D. 1700 (250 cal yr B.P.) Cascadia earthquake. The northern events define a great earthquake recurrence of ~500-530 years. The recurrence times and averages are supported by the thickness of hemipelagic sediment deposited between turbidite beds. The southern Oregon and northern California margins represent at least three segments that include all of the northern ruptures, as well as ~22 thinner turbidites of restricted latitude range that are correlated between multiple sites. At least two northern California sites, Trinidad and Eel Canyon/pools, record additional turbidites, which may be a mix of earthquake and sedimentologically or storm-triggered events, particularly during the early Holocene when a close connection existed between these canyons and associated river systems. The combined stratigraphic correlations, hemipelagic analysis, and 14C framework suggest that the Cascadia margin has three rupture modes: (1) 19-20 full-length or nearly full length ruptures; (2) three or four ruptures comprising the southern 50-70 percent of the margin; and (3) 18-20 smaller southern-margin ruptures during the past 10 k.y., with the possibility of additional southern-margin events that are presently uncorrelated. The shorter rupture extents and thinner turbidites of the southern margin correspond well with spatial extents interpreted from the limited onshore paleoseismic record, supporting margin segmentation of southern Cascadia. The sequence of 41 events defines an average recurrence period for the southern Cascadia margin of ~240 years during the past 10 k.y. Time-independent probabilities for segmented ruptures range from 7-12 percent in 50 years for full or nearly full margin ruptures to ~21 percent in 50 years for a southern-margin rupture. Time-dependent probabilities are similar for northern margin events at ~7-12 percent and 37-42 percent in 50 years for the southern margin. Failure analysis suggests that by the year 2060, Cascadia will have exceeded ~27 percent of Holocene recurrence intervals for the northern margin and 85 percent of recurrence intervals for the southern margin. The long earthquake record established in Cascadia allows tests of recurrence models rarely possible elsewhere. Turbidite mass per event along the Cascadia margin reveals a consistent record for many of the Cascadia turbidites. We infer that larger turbidites likely represent larger earthquakes. Mass per event and magnitude estimates also correlate modestly with following time intervals for each event, suggesting that Cascadia full or nearly full margin ruptures weakly support a time-predictable model of recurrence. The long paleoseismic record also suggests a pattern of clustered earthquakes that includes four or five cycles of two to five earthquakes during the past 10 k.y., separated by unusually long intervals. We suggest that the pattern of long time intervals and longer ruptures for the northern and central margins may be a function of high sediment supply on the incoming plate, smoothing asperities, and potential barriers. The smaller southern Cascadia segments correspond to thinner incoming sediment sections and potentially greater interaction between lower-plate and upper-plate heterogeneities. The Cascadia Basin turbidite record establishes new paleoseismic techniques utilizing marine turbidite-event stratigraphy during sea-level highstands. These techniques can be applied in other specific settings worldwide, where an extensive fault traverses a continental margin that has several active turbidite systems.

Analysis of Submarine Landslides and Canyons along the U.S. Atlantic Margin Using Extended Continental Shelf Mapping Data

NASA Astrophysics Data System (ADS)

Chaytor, J. D.; Brothers, D. S.; Ten Brink, U. S.; Hoy, S. K.; Baxter, C.; Andrews, B.

2013-12-01

U.S. Geological Survey (USGS) studies of the U.S. Atlantic continental slope and rise aim to understand the: 1) the role of submarine landslides in tsunami generation, and 2) the linkages between margin morphology and sedimentary processes, particularly in and around submarine canyon systems. Data from U.S. Extended Continental Shelf (ECS) and numerous subsequent mapping surveys have facilitated the identification and characterization of submarine landslides and related features in fine detail over an unprecedented spatial extent. Ongoing analysis of USGS collected piston cores, sub-bottom and multichannel seismic (MCS) reflection profiles, and an extensive suite of legacy MCS data from two landslides, the Southern New England landslide zone and the Currituck Landslide, suggest that the most recent major landslide events are pre-Holocene, but that failures were complex and most likely multi-phase, at times resulting in extensive overlapping debris deposits. Piston core records plus visual observations of the seafloor from recent TowCam deployments and NOAA Ship Okeanos Explorer ROV dives reveal ongoing development of colluvial wedge-style debris aprons at the base of scarps within these landslides, showing that these regions continue to evolve long after the initial failure events. Multibeam bathymetry data and MCS profiles along the upper slope reveal evidence for vertical fluid migration and possible seabed gas expulsion. These observations underscore the need to reevaluate the sources of pore fluid overpressure in slope sediments and their role in landslide generation. ECS and more recent multibeam mapping have provided the opportunity to investigate the full extent of submarine canyon morphology and evolution from Cape Hatteras up to the US-Canadian EEZ, which has led to better understanding of the important role of antecedent margin physiography on their development. Six submarine canyon systems along the margin (Veatch, Hydrographer, Hudson, Wilmington-Baltimore, Norfolk-Washington, and Hatteras) are being investigated from the canyon heads down to their deep-water submarine fans in an effort to characterize their sediment transport history and constrain the influences of external processes on their morphology. Each canyon-fan system is morphologically unique and is strongly controlled by source region, antecedent margin morphology, landslide and debris flow processes, and the long-term influence of deep-water (along-slope) currents.

Similarity and Differences of Cretaceous Magmatism in the Arctic Region

NASA Astrophysics Data System (ADS)

Peyve, A. A.

2018-03-01

The paper considers Cretaceous magmatism at the continental margin of the Arctic Region. It is shown that Cretaceous igneous rocks of this region are rather heterogeneous in age, composition, and geodynamic formation setting. This differentiates them from rocks of typical large igneous provinces (LIPs). Local areas of magmatic activity, their substantial remoteness them from one another, and significant distinctions in age, composition of rocks, and formation conditions prevent us from unreservedly combining all occurrences of Cretaceous magmatism at the continental margin of the Arctic Region into a common igneous province. The stage of tholeiitic magmatism in the Svalbard Archipelago, Franz Josef Land, Arctic Canada, and the Alpha-Mendeleev Rise, which can be considered an LIP, began in the Early Cretaceous and continued for a long time, at least until the Campanian. The magmatism apparently had a plume source and was caused by extension during opening of the Canada Basin. Tholeiitic magmatism gave way to the alkaline magmatism stage from the Campanian to the onset of the Paleocene, related to continental rifting at the initial stage of formation of Eurasian Basin in the Arctic Region. No convincing evidence for a genetic link between Early Cretaceous tholeiitic and Late Cretaceous alkaline magmatism is known at present, nor for the alkaline magmatism belonging to a plume source.

Time Matters: Increasing the Efficiency of Antarctic Marine Geology and Paleoceanography Expeditions by Providing Improved Sediment Chronology

NASA Astrophysics Data System (ADS)

Rosenheim, B. E.; Domack, E. W.; Shevenell, A.; Subt, C.

2015-12-01

To maximize the areal extent of Antarctic sedimentary records of past deglaciation, it is necessary to ensure more sediment cores can be adequately dated. Antarctic margin sediment is challenging to date due to the lack of preserved calcium carbonate, but the records contained in these sediments readily recount the history of deglaciation. Recent and continued development of new chronological methods for Antarctic margin sediments have allowed better use of the efforts of marine geological coring expeditions to the region. The development of Ramped PyrOx radiocarbon dating has allowed us to 1. improve dates in deglacial sediments where no carbonate is preserved, 2. date glacial sediments lying below the tills marking the last glaciation, and 3. compile core chronologies into a regional framework of ice shelf collapse that has eluded many marine geology campaigns over the last few decades. These advances in a fundamental aspect of geological sciences will put the U.S. and international community on a better foothold to interpret the past as it relates to our warming future. We will present these advances in chronology as well as the science that is enabled by them, while arguing that the future of Antarctic marine science also depends on investments in shore-based technologies that come at a relatively low cost.

Traction alopecia: the root of the problem

PubMed Central

Billero, Victoria; Miteva, Mariya

2018-01-01

Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. TA can also occur in the setting of religious and occupational traumatic hairstyling. In its later stages, the disease may progress into an irreversible scarring alopecia if traumatic hairstyling continues without appropriate intervention. The most common clinical presentation includes marginal alopecia and non-marginal patchy alopecia. A clue to the clinical diagnosis is the preservation of the fringe sign as opposed to its loss in frontal fibrosing alopecia (FFA). Dermoscopy can be helpful in the diagnosis and can detect the ongoing traction by the presence of hair casts. Histopathology can distinguish TA from alopecia areata, FFA, and patchy central centrifugal cicatricial alopecia. Currently, there is no cure. Therefore, it is imperative that clinicians educate high-risk populations about TA and those practices that may convey the risk of hair loss. PMID:29670386

Non-conventional optomechanical choppers: analysis and design of novel prototypes

NASA Astrophysics Data System (ADS)

Duma, Virgil-Florin; Demian, Dorin; Csukas, Eduard Sebastian; Pop, Nicolina; Cira, Octavian

2017-10-01

Optical choppers are widely used in laser systems - for light modulation and/or attenuation. In their most used and wellknown configuration, they are built as a rotational wheel with windows, which transforms a continuous-wave laser beam into a series of impulses with a certain frequency and profile. We briefly present the analysis and design we have completed for the classical chopper wheels (i.e., with windows with linear margins) for both top-hat and Gaussian laser beams. Further on, novel chopper wheels configurations, with outward or inward semi-circular (or with other non-linear shaped) margins of the windows is pointed out; we completed for them both analytic functions and simulations, for both top-hat and Gaussian beams, in order to deduce their transmission functions (i.e., the time profile of the laser impulses generated by the device). The stress of the presentation is put on the novel choppers with shafts (patent pending); their transmission functions are pointed out for top-hat laser beams. Finally, an example of such choppers is considered, with regard to the necessary Finite Element Analysis (FEA) that has to be performed for their rotational shaft. Both the mechanical stress and the deformations in the shaft have to be taken into account, especially at high rotational speeds of the mobile element.

Estimating the Cost of Standardized Student Testing in the United States.

ERIC Educational Resources Information Center

Phelps, Richard P.

2000-01-01

Describes and contrasts different methods of estimating costs of standardized testing. Using a cost-accounting approach, compares gross and marginal costs and considers testing objects (test materials and services, personnel and student time, and administrative/building overhead). Social marginal costs of replacing existing tests with a national…

The Eastern Sardinian Margin (Tyrrhenian Sea, Western Mediterranean) : a key area to study the rifting and post-breakup evolution of a back-arc passive continental margin

NASA Astrophysics Data System (ADS)

Gaullier, Virginie; Chanier, Frank; Vendeville, Bruno; Maillard, Agnès; Thinon, Isabelle; Graveleau, Fabien; Lofi, Johanna; Sage, Françoise

2016-04-01

The Eastern Sardinian passive continental margin formed during the opening of the Tyrrhenian Sea, which is a back-arc basin created by continental rifting and oceanic spreading related to the eastward migrating Apennine subduction system (middle Miocene to Pliocene). Up to now, rifting in this key area was considered to be pro parte coeval with the Messinian Salinity Crisis (MSC, 5.96-5.32 Ma). We use the MSC seismic markers and the deformation of viscous salt and its brittle overburden as proxies to better delineate the timing of rifting and post-rift reactivation, and especially to quantify vertical and horizontal movements. On this young, highly-segmented margin, the Messinian Erosion Surface and the Upper and Mobile Units are systematically associated, respectively, to basement highs and deeper basins, showing that a rifted deep-sea domain already existed by Messinian times, therefore a major pre-MSC rifting episode occurred across the entire domain. Data show that there are no signs of Messinian syn-rift sediments, hence no evidence for rifting after Late Tortonian times. Moreover, because salt tectonics creates fan-shaped geometries in sediments, syn-rift deposits have to be carefully re-examined to distinguish the effects of crustal tectonics (rifting) and salt tectonics. We also precise that rifting is clearly diachronous from the upper margin (East-Sardinia Basin) to the lower margin (Cornaglia Terrace) with two unconformities, attributed respectively to the necking and to the lithospheric breakup unconformities. The onshore part of the upper margin has been recently investigated in order to characterize the large crustal faults affecting the Mesozoic series (geometry, kinematics and chronology) and to decipher the role of the structural inheritance and of the early rifting. Seaward, we also try to constrain the architecture and timing of the continent-ocean transition, between the hyper-extended continental crust and the first oceanic crust. Widespread post-breakup deformation also occurred during the Pliocene. Some Pliocene vertical movements have been evidenced by discovering localized gravity gliding of the salt and its Late Messinian (UU) and Early Pliocene overburden. To the South, crustal-scale southward tilting triggered along-strike gravity gliding of salt and cover recorded by upslope extension and downslope shortening. To the North, East of the Baronie Ridge, there was some post-salt crustal activity along a narrow N-S basement trough, bounded by crustal faults. The salt geometry would suggest that nothing happened after Messinian times, but some structural features (confirmed by analogue modelling) show that basement fault slip was accommodated by lateral salt flow, which thinned upslope and thickened downslope, while the overlying sediments remained sub-horizontal. Along the inner domain of Eastern Sardinian margin, the post-rift deformation style greatly varies. Compressional structures (reverse faults and folds) are observed both onshore and offshore while post-rift extensional structures are mainly identified offshore. Such late deformation could be attributed to mechanisms acting alone or combined, such as : i. the reactivation of the margin, as already described for the Ligurian, Algerian or South-Balearic margins due to the Eurasian-African convergence ; 2. the Zanclean reflooding and the resulting water overload on the elastic lithosphere ; 3. an episodic mantle upwelling.

Dopamine Reward Prediction Error Responses Reflect Marginal Utility

PubMed Central

Stauffer, William R.; Lak, Armin; Schultz, Wolfram

2014-01-01

Summary Background Optimal choices require an accurate neuronal representation of economic value. In economics, utility functions are mathematical representations of subjective value that can be constructed from choices under risk. Utility usually exhibits a nonlinear relationship to physical reward value that corresponds to risk attitudes and reflects the increasing or decreasing marginal utility obtained with each additional unit of reward. Accordingly, neuronal reward responses coding utility should robustly reflect this nonlinearity. Results In two monkeys, we measured utility as a function of physical reward value from meaningful choices under risk (that adhered to first- and second-order stochastic dominance). The resulting nonlinear utility functions predicted the certainty equivalents for new gambles, indicating that the functions’ shapes were meaningful. The monkeys were risk seeking (convex utility function) for low reward and risk avoiding (concave utility function) with higher amounts. Critically, the dopamine prediction error responses at the time of reward itself reflected the nonlinear utility functions measured at the time of choices. In particular, the reward response magnitude depended on the first derivative of the utility function and thus reflected the marginal utility. Furthermore, dopamine responses recorded outside of the task reflected the marginal utility of unpredicted reward. Accordingly, these responses were sufficient to train reinforcement learning models to predict the behaviorally defined expected utility of gambles. Conclusions These data suggest a neuronal manifestation of marginal utility in dopamine neurons and indicate a common neuronal basis for fundamental explanatory constructs in animal learning theory (prediction error) and economic decision theory (marginal utility). PMID:25283778

Northeastern Brazilian margin: Regional tectonic evolution based on integrated analysis of seismic reflection and potential field data and modelling

NASA Astrophysics Data System (ADS)

Blaich, Olav A.; Tsikalas, Filippos; Faleide, Jan Inge

2008-10-01

Integration of regional seismic reflection and potential field data along the northeastern Brazilian margin, complemented by crustal-scale gravity modelling, is used to reveal and illustrate onshore-offshore crustal structure correlation, the character of the continent-ocean boundary, and the relationship of crustal structure to regional variation of potential field anomalies. The study reveals distinct along-margin structural and magmatic changes that are spatially related to a number of conjugate Brazil-West Africa transfer systems, governing the margin segmentation and evolution. Several conceptual tectonic models are invoked to explain the structural evolution of the different margin segments in a conjugate margin context. Furthermore, the constructed transects, the observed and modelled Moho relief, and the potential field anomalies indicate that the Recôncavo, Tucano and Jatobá rift system may reflect a polyphase deformation rifting-mode associated with a complex time-dependent thermal structure of the lithosphere. The constructed transects and available seismic reflection profiles, indicate that the northern part of the study area lacks major breakup-related magmatic activity, suggesting a rifted non-volcanic margin affinity. In contrast, the southern part of the study area is characterized by abrupt crustal thinning and evidence for breakup magmatic activity, suggesting that this region evolved, partially, with a rifted volcanic margin affinity and character.

Factors of U.S. Hospitals Associated with Improved Profit Margins: An Observational Study.

PubMed

Ly, Dan P; Cutler, David M

2018-02-14

Hospitals face financial pressure from decreased margins from Medicare and Medicaid and lower reimbursement from consolidating insurers. The objectives of this study are to determine whether hospitals that became more profitable increased revenues or decreased costs more and to examine characteristics associated with improved financial performance over time. The design of this study is retrospective analyses of U.S. non-federal acute care hospitals between 2003 and 2013. There are 2824 hospitals as subjects of this study. The main measures of this study are the change in clinical operating margin, change in revenues per bed, and change in expenses per bed between 2003 and 2013. Hospitals that became more profitable had a larger magnitude of increases in revenue per bed (about $113,000 per year [95% confidence interval: $93,132 to $133,401]) than of decreases in costs per bed (about - $10,000 per year [95% confidence interval: - $28,956 to $9617]), largely driven by higher non-Medicare reimbursement. Hospitals that improved their margins were larger or joined a hospital system. Not-for-profit status was associated with increases in operating margin, while rural status and having a larger share of Medicare patients were associated with decreases in operating margin. There was no association between improved hospital profitability and changes in diagnosis related group weight, in number of profitable services, or in payer mix. Hospitals that became more profitable were more likely to increase their admissions per bed per year. Differential price increases have led to improved margins for some hospitals over time. Where significant price increases are not possible, hospitals will have to become more efficient to maintain profitability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGinnis, J.P.; Karner, G.D.; Driscoll, N.W.

The tectonic and stratigraphic development of the Congo continental margin reflects the timing, magnitude, and distribution of lithospheric extension responsible for its formation. Details of the lithospheric extension process are recorded in the stratigraphic successions preserved along and across the margin. By using the stratal relationships (e.g., onlap, downlap, and truncation) and lithofacies determined from seismic reflection and exploratory well data as input into our basin-modeling strategy, we have developed an integrated approach to determine the relationship between the timing, magnitude, and distribution of lithospheric extension across the margin. Two hinge zones, an eastern and Atlantic hinge formed along themore » Congo margin in response to discrete extensional events occurring from the Berriasian to the Aptian. The eastern hinge zone demarcates the eastern limit of the broadly distributed Berriasian extension. This extension resulted in the formation of deep anoxic, lacustrine systems. In contrast, the Atlantic hinge, located [approximately]90 km west of the eastern hinge, marks the eastern limit of a second phase of extension, which began in the Hauterivian. Consequent footwall uplift and rotation exposed the earlier synrift and prerift stratigraphy to at least wave base causing varying amounts of erosional truncation across the Atlantic hinge zone along much of the Gabon, Congo, and Angola margins. The absence of the Melania Formation across the Congo margin implies that uplift of the Atlantic hinge was relatively minor compared to that across the Angola and Gabon margins. In addition, material eroded from the adjacent and topographically higher hinge zones may in part account for the thick wedge of sediment deposited seaward of the Congo Atlantic hinge. A third phase of extension reactivated both the eastern and Atlantic hinge zones and was responsible for creating the accommodation space for Marnes Noires source rock deposition.« less

Passive recording of an active transform, an example from the Levant continental margin and the Dead Sea Fault

NASA Astrophysics Data System (ADS)

Lang, Guy; Lazar, Michael; Schattner, Uri

2017-04-01

Transform faults accommodate lateral motion between two adjacent plates. Records of plate motion and consequent boundary development on land is, at times, scarce and limited to structures along the fault axis. Investigation of a passive continental margin adjacent to the plate boundary might broaden the scope and provide estimates for its structural development. To examine this hypothesis, we analyzed depth and time migrated 3D seismic data together with four boreholes located along the southern Levant continental margin, ca. 100 Km from the continental Dead Sea fault (DSF). The analysis focus on the Plio-Pleistocene sequence, a key period in the development of the DSF. It includes formation of structural maps, stacking pattern investigation and calculation of sedimentation rates based on decompacted 3D depth data. These, in turn, enabled the reconstruction of margin development. This includes Messinian-earliest Zanclean NNE-SSW sinistral strike-slip faulting followed by Zanclean-Late Gelasian syn-depositional folding striking in the same direction. Abrupt change is marked by the Top Gelasian surface that shows indications of regional mass slumping. Successive Mid-Late Pleistocene progradation marks a basinward shift of the depocenter. Progradation controls margin sedimentation rates during the mid-late Pleistocene. These were found to increase throughout the whole Plio-Pleistocene, in contrast to reported sediment discharge from the Nile, which was shown to decrease after the Gelasian. Correlations to onshore findings, suggest that the continental margin records strain localization on the DSF during the Pliocene-Gelasian. This trend peaked at 1.8 Ma when short wavelength strain ceased along the margin, and differential subsidence commenced basinwards. This is attributed to consequent deepening of the DSF plate boundary.

Upper-Crustal Structure of the Møre Margin, Offshore-Norway

NASA Astrophysics Data System (ADS)

Moronfoye, A. T.; Ronen, S.; Klemperer, S. L.; Alves, G. C.

2016-12-01

The Møre Margin is a segment of the volcanic passive continental margin offshore mid Norway which formed as a result of the early-Cenozoic opening of the Norwegian-Greenland Sea. The Møre Margin has been interpreted as a `volcanic rifted margin', with voluminous basaltic lavas accompanied by a mafic underplate of velocities greater than 7 km/s. The Møre Margin is a region of interest for oil and gas exploration, and characterization of a layer with seismic velocities above 7 km/s could help understand the time-temperature history of its basin. However, seismic exploration of the Møre Margin is greatly complicated by the problems of sub-basalt imaging. We picked refraction arrivals from 2D seismic data acquired by Seabed Geosolutions using a common-receiver gather from a line of 179 4-component ocean-bottom nodes that spanned 85 km west to east. The source was an airgun of 4000 in3 and was fired at 100 m intervals to a maximum offset of 100 km. We used Seismic Unix to apply a linear-moveout reduction velocity, and estimated the velocities and thicknesses of the layers down to a prominent reflector believed to be either the basalt layer or the mafic underplate. The P-wave velocity, Vp, ranges from about 2 km/s at the seabed to 2.4 km/s above the prominent reflecting layer which has a velocity of 5 km/s. Using the horizontal component data, we identified a converted S wave refraction and used its travel time to estimate an average Vp/Vs ratio of just under 2 in the 2 km/s sedimentary layer, a value consistent with compacted sediments. Based on the seismic velocities calculated and an assessment of laboratory sonic-velocity measurements, we concluded that the primary reflector is likely weathered or vesicular basalt. We also generated synthetic travel-time curves from a velocity model that included a mafic underplate at a depth of about 20 km, as proposed in earlier studies. Our calculated refraction travel time curves suggest that our 85 km receiver line may be too short to identify a mafic underplate at such depth, even with a velocity greater than 7 km/s.

Investigating the relationship between neighborhood poverty and mortality risk: A marginal structural modeling approach

PubMed Central

Do, D. Phuong; Wang, Lu; Elliott, Michael R.

2013-01-01

Extant observational studies generally support the existence of a link between neighborhood context and health. However, estimating the causal impact of neighborhood effects from observational data has proven to be a challenge. Omission of relevant factors may lead to overestimating the effects of neighborhoods on health while inclusion of time-varying confounders that may also be mediators (e.g., income, labor force status) may lead to underestimation. Using longitudinal data from the 1990 to 2007 years of the Panel Study of Income Dynamics, this study investigates the link between neighborhood poverty and overall mortality risk. A marginal structural modeling strategy is employed to appropriately adjust for simultaneous mediating and confounding factors. To address the issue of possible upward bias from the omission of key variables, sensitivity analysis to assess the robustness of results against unobserved confounding is conducted. We examine two continuous measures of neighborhood poverty – single-point and a running average. Both were specified as piece-wise linear splines with a knot at 20 percent. We found no evidence from the traditional naïve strategy that neighborhood context influences mortality risk. In contrast, for both the single-point and running average neighborhood poverty specifications, the marginal structural model estimates indicated a statistically significant increase in mortality risk with increasing neighborhood poverty above the 20 percent threshold. For example, below 20 percent neighborhood poverty, no association was found. However, after the 20 percent poverty threshold is reached, each 10 percentage point increase in running average neighborhood poverty was found to increase the odds for mortality by 89 percent [95% CI = 1.22, 2.91]. Sensitivity analysis indicated that estimates were moderately robust to omitted variable bias. PMID:23849239

Shelfal sediment transport by undercurrents forces turbidity current activity during high sea level, Chile continental margin

NASA Astrophysics Data System (ADS)

Bernhardt, Anne; Hebbeln, Dierk; Regenberg, Marcus; Lückge, Andreas; Strecker, Manfred. R.

2016-04-01

Understanding the links between terrigenous sediment supply and marine transport and depositional processes along tectonically active margins is essential to decipher turbidite successions as potential archives of climatic and seismic forcings and to comprehend timing and quantity of marine clastic deposition. Sequence stratigraphic models predict coarse-grained terrigenous sediment delivery to deep-marine sites mainly during sea-level fall and lowstand. Marine clastic deposition during periods of transgression and highstand has been attributed to the continued geomorphic connectivity between terrestrial sediment sources and marine sinks (e.g., rivers connected to submarine canyons) often facilitated by narrow shelves, high sediment supply causing delta migration to the shelf edge, and/or abrupt increases in sediment supply due to climatic variability or catastrophic events. To decipher the controls on Holocene highstand turbidite deposition, we analyzed twelve sediment cores of spatially disparate, coeval Holocene turbidite systems along the Chile margin (29-40°S) with changing climatic and geomorphic characteristics but uniform changes of sea level. Intraslope basins in north-central Chile (29-33°S) offshore a narrow to absent shelf record a shut-off of turbidite activity during the Holocene. In contrast, core sites in south-central Chile (36-40°S) offshore a wide continental shelf have repeatedly experienced turbidite deposition during sea-level highstand conditions, even though most of the depocenters are not connected via canyons to sediment sources. The interplay of stable high sediment supply related to strong onshore precipitation in combination with a wide shelf, over which undercurrents move sediment towards the shelf edge, appears to control Holocene turbidite sedimentation and sediment export to the deep sea.

Plate tectonic model for the oligo-miocene evolution of the western Mediterranean

NASA Astrophysics Data System (ADS)

Cohen, Curtis R.

1980-10-01

This paper outlines a plate tectonic model for the Oligo-Miocene evolution of the western Mediterranean which incorporates recent data from several tectonic domains (Corsica, Sardinia, the Kabylies, Balearic promontory, Iberia, Algero-Provençal Basin and Tunisian Atlas). Following late Mesozoic anticlockwise rotation of the Iberian peninsula (including the Balearic promontory and Sardinia), late Eocene collision occurred between the Kabylies and Balearic promontory forming a NE-trending suture with NW-tectonic polarity. As a result of continued convergence between the African and European plates, a polarity flip occurred and a southward-facing trench formed south of the Kabylie—Balearic promontory suture. During late Oligocene time an E-W-trending arc and marginal basin developed behind the southward-facing trench in the area of the present-day Gulf of Lion. Opening of this basin moved the Corsica—Sardinia—Calabria—Petit Kabylie—Menorca plate southward, relative to the African plate. Early Miocene back-arc spreading in the area between the Balearic promontory and Grand Kabylie emplaced the latter in northern Algeria and formed the South Balearic Basin. Coeval with early Miocene back-arc basin development, the N-S-extension in the Gulf of Lion marginal basin changed to a more NW-SE direction causing short-lived extension in the area of the present-day Valencia trough and a 30° anticlockwise rotation of the Corsica-Sardinia-Calabria—Petit Kabylie plate away from the European plate. Early—middle Miocene deformation along the western Italian and northeastern African continental margins resulted from this rotation. During the early late Miocene (Tortonian), spreading within a sphenochasm to the southwest of Sardinia resulted in the emplacement of Petit Kabylie in northeastern Algeria.

Interaction of the Siberian craton and Central Asian Orogenic Belt (CAOB) recorded by detrital zircons from Transbaikalia

NASA Astrophysics Data System (ADS)

Powerman, V.; Shatsillo, A.; Chumakov, N.; Kapitonov, I.; Hourigan, J. K.

2015-12-01

The goal of this study is to pinpoint the beginning of interaction of two gigantic crustal structures: the Siberian Craton and the Central Asian Orogenic Belt (CAOB). We hypothesize that the beginning of convergence should be recorded in the Neoproterozoic passive margin strata of Siberian Craton by the first appearance of extraregional Neoproterozoic zircons. In order to test this hypothesis, we have acquired U-Pb zircon age distributions from twelve Neoproterozoic clastic rocks from the Baikal-Patom margin of Siberia and one sample from the volcaniclastic Padrinsky Group that was deposited atop accreted CAOB crust. Stratigraphically lower strata from the Siberian margin yield Archean - Paleoproterozoic detrital zircon ages, which are similar to, and probably derived from the Siberian Precambrian craton. A few extra-regional Mesoproterozoic grains are also present. The provenance shift happens in the upper portion of the section and is marked by a strong influx of extra-regional Neoproterozoic sediments. The youngest grains of 610 Ma constrain the sedimentation age and confine the timing of interaction between CAOB and Siberia in this region. Neoproterozoic zircons also dominate the overlying sedimentary unit, suggesting the continuance of the convergence. The coeval volcanoclastic unit on the CAOB side has a similar U-Pb detrital age distribution, strengthening the provenance link. Analysis of the local tectonics suggests that the beginning of accretion might have started even before the first appearance of Neoproterozoic zircon: during the development of a regional unconformity, capped by 635 Ma (?) "Snowball Earth" tillites of Dzhemkukan Fm. The absence of Neoproterozoic zircons in Dzhemkukan Fm. is probably explained by a thin-skinned tectonics that did not result in massive orogenesis . Our data are in good correlation with other Neoproterozoic sedimentary basins of southern Siberian Craton, including Cisbaikalia and Bodaibo Synclinorium.

Surface expression of Eastern Mediterranean slab dynamics: Uplift at the SW margin of the Central Anatolian Plateau

NASA Astrophysics Data System (ADS)

Schildgen, T. F.; Cosentino, D.; Caruso, A.; Yildirim, C.; Echtler, H.; Strecker, M. R.

2011-12-01

The Central Anatolian plateau in Turkey borders one of the most complex tectonic regions on Earth, where collision of the Arabian plate with Eurasia in Eastern Anatolia transitions to a cryptic pattern of subduction of the African beneath the Eurasian plate, with concurrent westward extrusion of the Anatolian microplate. Topographic growth of the southern margin of the Central Anatolian plateau has proceeded in discrete stages that can be distinguished based on the outcrop pattern and ages of uplifted marine sediments. These marine units, together with older basement rocks and younger continental sedimentary fills, also record an evolving nature of crustal deformation and uplift patterns that can be used to test the viability of different uplift mechanisms that have contributed to generate the world's third-largest orogenic plateau. Late Miocene marine sediments outcrop along the SW plateau margin at 1.5 km elevation, while they blanket the S and SE margins at up to more than 2 km elevation. Our new biostratigraphic data limit the age of 1.5-km-high marine sediments along the SW plateau margin to < 7.17 Ma, while regional lithostratigraphic correlations imply that the age is < 6.7 Ma. After reconstructing the post-Late Miocene surface uplift pattern from elevations of uplifted marine sediments and geomorphic reference surfaces, it is clear that regional surface uplift reaches maximum values along the modern plateau margin, with the SW margin experiencing less cumulative uplift compared to the S and SE margins. Our structural measurements and inversion modeling of faults within the uplifted region agree with previous findings in surrounding regions, with early contraction followed by strike-slip and extensional deformation. Shallow earthquake focal mechanisms show that the extensional phase has continued to the present. Broad similarities in the onset of surface uplift (after 7 Ma) and a change in the kinematic evolution of the plateau margin (after 8 Ma) suggest that these phenomena may have been linked with a change in the tectonic stress field associated with the process(es) causing post-7 Ma surface uplift. The complex geometry of lithospheric slabs beneath the southern plateau margin, early Pliocene to recent alkaline volcanism, and the localized uplift pattern with accompanying tensional/transtensional stresses point toward slab tearing and localized heating at the base of the lithosphere as a probable mechanism for post-7 Ma uplift of the SW margin. Considering previous work in the region, slab break-off is more likely responsible for non-contractional uplift along the S and SE margins. Overall there appears to be an important link between slab dynamics and surface uplift across the whole southern margin of the Central Anatolian plateau.

Multidecadal fCO2 Increase Along the United States Southeast Coastal Margin

NASA Astrophysics Data System (ADS)

Reimer, Janet J.; Wang, Hongjie; Vargas, Rodrigo; Cai, Wei-Jun

2017-12-01

Coastal margins could be hotspots for acidification due to terrestrial-influenced CO2 sources. Currently there are no long-term (>20 years) records from biologically important coastal environments that could demonstrate sea surface CO2 fugacity (fCO2) and pH trends. Here, multidecadal fCO2 trends are calculated from underway and moored time series observations along the United States southeast coastal margin, also referred to as the South Atlantic Bight (SAB). fCO2 trends across the SAB, derived from ˜26 years of cruises and ˜9.5 years from a moored time series, range from 3.0 to 4.5 µatm yr-1, and are greater than the open ocean increases. The pH decline related to the fCO2 increases could be as much as -0.004 yr-1; a rate greater than that expected from atmospheric-influenced pH alone. We provide evidence that fCO2 increases and pH decreases on an ocean margin can be faster than those predicted for the open ocean from atmospheric influence alone. We conclude that a substantial fCO2 increase across the marginal SAB is due to both increasing temperature on the middle and outer shelves, but to lateral land-ocean interactions in the coastal zone and on inner shelf.

A comparative analysis of toluidine blue with frozen section in oral squamous cell carcinoma

PubMed Central

2012-01-01

Background Surgical excision of the primary tumor with safe margins remains the mainstay of treatment for oral cavity squamous cell carcinoma (OSCC). The standard of care for assessment of intraoperative margins is frozen section histopathology. Unfortunately the facility is not available at most centers in limited resource countries. Toluidine blue, a metachromatic dye, has been well described in clinical identification of malignant and premalignant lesion in the oral cavity. Considering this we decided to explore intraoperative use of toluidine blue staining, in comparison with frozen sections, for the assessment of tumor-free margins. Methods After obtaining clearance from the in-house ethical review committee, a prospective study was conducted at Aga Khan University Hospital, Karachi, from August 15, 2009 to March 14, 2010. A sample of 56 consenting patients with biopsy-proven OSCC were included in the study, giving us 280 tumor margins. Margins were analyzed using toluidine blue staining and frozen section histopathology. A receiver operator curve (ROC) was then applied to compare assessment of margin status by toluidine blue and frozen section. Results Of the 280 examined margins 11 stained positive with toluidine blue, three were positive on frozen section biopsy, and three were positive on final histopathology. Toluidine blue staining had sensitivity and specificity of 100% and 97%, respectively. The diagnostic accuracy of toluidine blue was found to be 97.1% with a positive predictive value (PPV) of 27.2% and a negative predictive value (NPV) of 100%. Conclusions Toluidine blue can be used as an effective screening modality for the assessment of intraoperative margins in resource limited environments and reducing the number of frozen section biopsies performed. Further by providing real-time clinical information within minutes it can reduce indirect costs such as operating room time. It may also be used as an ad hoc for frozen section biopsies where frozen section facilities are available. PMID:22500814

Comparison of marginal bone loss and implant success between axial and tilted implants in maxillary All-on-4 treatment concept rehabilitations after 5 years of follow-up.

PubMed

Hopp, Milena; de Araújo Nobre, Miguel; Maló, Paulo

2017-10-01

There is need for more scientific and clinical information on longer-term outcomes of tilted implants compared to implants inserted in an axial position. Comparison of marginal bone loss and implant success after a 5-year follow-up between axial and tilted implants inserted for full-arch maxillary rehabilitation. The retrospective clinical study included 891 patients with 3564 maxillary implants rehabilitated according to the All-on-4 treatment concept. The follow-up time was 5 years. Linear mixed-effect models were performed to analyze the influence of implant orientation (axial/tilted) on marginal bone loss and binary logistic regression to assess the effect of patient characteristics on occurrence of marginal bone loss >2.8 mm. Only those patients with measurements of at least one axial and one tilted implant available were analyzed. This resulted in a data set of 2379 implants (1201 axial, 1178 tilted) in 626 patients (=reduced data set). Axial and tilted implants showed comparable mean marginal bone losses of 1.14 ± 0.71 and 1.19 ± 0.82 mm, respectively. Mixed model analysis indicated that marginal bone loss levels at 5 years follow up was not significantly affected by the orientation (axial/tilted) of the implants in the maxillary bone. Smoking and female gender were associated with marginal bone loss >2.8 mm in a logistic regression analysis. Five-year implant success rates were 96%. The occurrence of implant failure showed to be statistically independent from orientation. Within the limitations of this study and considering a follow-up time of 5 years, it can be concluded that tilted implants behave similarly with regards to marginal bone loss and implant success in comparison to axial implants in full-arch rehabilitation of the maxilla. Longer-term outcomes (10 years +) are needed to verify this result. © 2017 Wiley Periodicals, Inc.

Comparative evaluation of effects of bleaching on color stability and marginal adaptation of discolored direct and indirect composite laminate veneers under in vivo conditions.

PubMed

Jain, Veena; Das, Taposh K; Pruthi, Gunjan; Shah, Naseem; Rajendiran, Suresh

2015-01-01

Change in color and loss of marginal adaptation of tooth colored restorative materials is not acceptable. Bleaching is commonly used for treating discolored teeth. However, the literature is scanty regarding its effect on color and marginal adaptation of direct and indirect composite laminate veneers (CLVs) under in vivo conditions. Purpose of the study was to determine the effect of bleaching on color change and marginal adaptation of direct and indirect CLVs over a period of time when exposed to the oral environment. For this purpose, a total of 14 subjects irrespective of age and sex indicated for CLV restorations on maxillary anterior teeth were selected following the inclusion and exclusion criteria. For each subject, indirect CLVs were fabricated and looted in the first quadrant (Group 1) and direct CLV's (Group 2), were given in the second quadrant. Color change was assessed clinically using intra-oral digital spectrophotometer and marginal adaptation was assessed on epoxy resin replica of the tooth-restoration interface under scanning electron microscope. After 6 months, the subjects underwent a home bleaching regimen for 14 days using 10% carbamide peroxide. The assessment of color change and marginal adaptation was done at 6 months after veneering (0-180 days), immediately after the bleaching regimen (0-194 days) and 3 months after the bleaching regimen (0-284 days). The difference in median color change (ΔE) between the groups was tested using Wilcoxon rank sum test while the median color change with time within the groups was tested using Wilcoxon signed rank test. The difference in the rates of marginal adaptation was tested between the groups using Chi-square/Fisher's exact test. Bleaching led to statistically significant color change at cervical (CE), middle and incisal (IE) regions when direct and indirect composites were compared (P < 0.05). During intra-group comparison, direct CLV's showed significant color change at CE and IE regions when ΔE was compared at 180 days and 284 days (CE 10 vs. CE 30, P = 0.008, IE 10 vs. IE 30, P = 0.003). No significant differences were found when within group comparison was made for indirect laminates. Intergroup comparison between the groups showed significant difference in marginal adaptation at CE margin at all.time points (at baseline, P = 0.005; at 180 days, P = 0.007; 194 days, P = 0.025; at 284 days, P = 0.067). After bleaching, indirect CLVs performed better in terms of color stability whereas direct CLVs performed better in terms of marginal adaptation. Indirect composites should be preferred to direct composites as veneering materials as they have better color stability. Special attention should be given to their marginal adaptation especially in the CE region. Bleaching should be avoided in patients with composite restorations in the mouth.

Evaluating the learning curve for robot-assisted laparoscopic radical cystectomy.

PubMed

Pruthi, Raj S; Smith, Angela; Wallen, Eric M

2008-11-01

We seek to describe the learning curve of robot-assisted laparoscopic radical cystectomy by evaluating some of the surgical, oncologic, and clinical outcomes in our initial experience with 50 consecutive patients undergoing this novel procedure. Fifty consecutive patients (representing our initial experience with robot-assisted cystectomy) underwent radical cystectomy and urinary diversion from January 2006 to December 2007. Several different metrics were used to evaluate the learning curve of this procedure, including estimated blood loss (EBL), operative (OR) time, pathologic outcomes, and complication rate. We evaluated patients as a continuous variable, divided into five distinct time periods (quintiles), and stratified by first half and second half of robotic experience. EBL was not significantly lower until the third quintile (patients 21-30), after which further significant reductions were not observed. Mean OR time declined between each quintile for the first 30 patients (1-10 v 11-20 v 21-30). No significant declines occurred after the third quintile (21-30). When evaluated as a continuous variable, the statistical cut point at which no further significant reductions were observed was after patient 20 for OR time. No differences were observed with regard to time to flatus, bowel movement, or hospital discharge. Furthermore, complications were not different between the initial 25 patients and the most recent patients. There has been no case of a positive margin, and there was only one inadvertent bladder entry. Lymph node yield has also not significantly changed over time. This report helps to define the learning curve associated with robot-assisted laparoscopic radical cystectomy for bladder cancer. Despite the higher OR times and blood loss that is observed early in the learning curve, no such compromises are observed with regard to these oncologic parameters even early in the experience.

Mental Depreciation and Marginal Decision Making

PubMed

Heath; Fennema

1996-11-01

We propose that individuals practice "mental depreciation," that is, they implicitly spread the fixed costs of their expenses over time or use. Two studies explore how people spread fixed costs on durable goods. A third study shows that depreciation can lead to two distinct errors in marginal decisions: First, people sometimes invest too much effort to get their money's worth from an expense (e.g., they may use a product a lot to spread the fixed expense across more uses). Second, people sometimes invest too little effort to get their money's worth: When people add a portion of the fixed cost to the current costs, their perceived marginal (i.e., incremental) costs exceed their true marginal costs. In response, they may stop investing because their perceived costs surpass the marginal benefits they are receiving. The latter effect is supported by two field studies that explore real board plan decisions by university students.

Statistical analysis of mixed recurrent event data with application to cancer survivor study

PubMed Central

Zhu, Liang; Tong, Xingwei; Zhao, Hui; Sun, Jianguo; Srivastava, Deo Kumar; Leisenring, Wendy; Robison, Leslie L.

2014-01-01

Event history studies occur in many fields including economics, medical studies and social science. In such studies concerning some recurrent events, two types of data have been extensively discussed in the literature. One is recurrent event data that arise if study subjects are monitored or observed continuously. In this case, the observed information provides the times of all occurrences of the recurrent events of interest. The other is panel count data, which occur if the subjects are monitored or observed only periodically. This can happen if the continuous observation is too expensive or not practical and in this case, only the numbers of occurrences of the events between subsequent observation times are available. In this paper, we discuss a third type of data, which is a mixture of recurrent event and panel count data and for which there exists little literature. For regression analysis of such data, a marginal mean model is presented and we propose an estimating equation-based approach for estimation of regression parameters. A simulation study is conducted to assess the finite sample performance of the proposed methodology and indicates that it works well for practical situations. Finally it is applied to a motivating study on childhood cancer survivors. PMID:23139023

Multidisciplinary scientific program of investigation of the structure and evolution of the Demerara marginal plateau

NASA Astrophysics Data System (ADS)

Loncke, Lies; Basile, Christophe; Roest, Walter; Graindorge, David; Mercier de Lépinay, Marion; Klinghelhoefer, Frauke; Heuret, Arnauld; Pattier, France; Tallobre, Cedric; Lebrun, Jean-Frédéric; Poetisi, Ewald; Loubrieu, Benoît; Iguanes, Dradem, Margats Scientific Parties, Plus

2017-04-01

Mercier de Lépinay et al. published in 2016 an updated inventory of transform passive margins in the world. This inventory shows that those margins represent 30% of continental passive margins and a cumulative length of 16% of non-convergent margins. It also highlights the fact that many submarine plateaus prolong transform continental margins, systematically at the junction of oceanic domains of different ages. In the world, we identified twenty of those continental submarine plateaus (Falklands, Voring, Demerara, Tasman, etc). Those marginal plateaus systematically experiment two phases of deformation: a first extensional phase and a second transform phase that allows the individualization of those submarine reliefs appearing on bathymetry as seaward continental-like salients. The understanding of the origin, nature, evolution of those marginal plateaus has many scientific and economic issues. The Demerara marginal plateau located off French Guiana and Surinam belongs to this category of submarine provinces. The French part of this plateau has been the locus of a first investigation in 2003 in the framework of the GUYAPLAC cruise dedicated to support French submissions about extension of the limit of the continental shelf beyond 200 nautical miles. This cruise was the starting point of a scientific program dedicated to geological investigations of the Demerara plateau that was sustained by different cruises and collaborations (1) IGUANES (2013) that completed the mapping of this plateau including off Surinam, allowed to better understand the segmentation of the Northern edge of this plateau, and to evidence the combined importance of contourite and mass-wasting processes in the recent sedimentary evolution of this domain, (2) Collaboration with TOTAL (Mercier de Lépinay's PhD thesis) that allowed to better qualify the two main phases of structural evolution of the plateau respectively during Jurassic times for its Western border, Cretaceous times for its Northern and Eastern border (2) DRADEM (2016) (see poster session) that better mapped the continental slope domain of the transform margin north of the Demerara plateau and was dedicated to the dredging of rocks outcropping on the continental slope, suspected to be Cretaceous in age and older, (3) MARGATS (2016) (see poster session) that was dedicated to the better understanding of the internal structure of the plateau and its different margins using multi-channels seismic and refraction methods. The combination of all those experiments allow us to paint an integrated portrait of the Demerara marginal plateau - that may be very useful in understanding the processes involved (1) in the individualization of such plateaus (volcanism, heritages, kinematics, …) (2) in their evolution (subsidence, mass-wasting processes, domains of deep-sea current acceleration). In the future, those scientific advances may allow to better define the natural resources associated with such marginal domains.

Visualizing Queer Spaces: LGBTQ Students and the Traditionally Heterogendered Institution

ERIC Educational Resources Information Center

Pryor, Jonathan T.

2018-01-01

As colleges and universities have increased campus programs, LGBTQ students continue to experience marginalization within the very spaces intended to support them. This study explored how LGBTQ college students experienced campus climate at a Midwest Urban Public (MUP) institution through a framework of the traditionally heterogendered institution…

Inclusion and Attitudes of Adolescents in a Camp Setting

ERIC Educational Resources Information Center

Musher, Deborah Ann

2016-01-01

Despite increased inclusion of individuals with special needs in educational and leisure settings, people with disabilities continue to experience social isolation. Research indicates that negative attitudes play an important role in contributing to this marginalization. This study examined the impact of an inclusion program at a residential…

Exploring How an Elementary Teacher Plans and Implements Social Studies Inquiry

ERIC Educational Resources Information Center

Thacker, Emma S.; Friedman, Adam M.; Fitchett, Paul G.; Journell, Wayne; Lee, John K.

2018-01-01

Social studies continues to be marginalized in elementary grades, yet the "C3 Framework" and its Inquiry Arc offer possibilities for high-quality elementary social studies instruction. However, the "C3 Framework" requires that teachers possess an adequate understanding of how to implement inquiry within the various social…

Information Poverty and the Latino Community: Implications for Social Work Practice and Social Work Education.

ERIC Educational Resources Information Center

McNutt, John G.; Queiro-Tajalli, Irene; Boland, Katherine M.; Campbell, Craig

2001-01-01

Education level, computer ownership, and technology and information access determine one's status in the new information economy. Interventions such as community computer networks, telecommuting centers, grassroots electronic commerce, and volunteer technology corps can help Latinos and other marginalized groups overcome continued disadvantage.…

An Inventory and Use Analysis of Information Systems on Small Farms in Pennsylvania

ERIC Educational Resources Information Center

Adams, Jean S.

2007-01-01

Across the United States, today's farm operators face continuing challenges from global competition, increasing production costs, changing technology, increased regulations, scarce resources, and lower profit margins. To face these challenges, farm operators need to gather and utilize information allowing them to make informed decisions. Several…

17 CFR 242.606 - Disclosure of order routing information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES... of total customer orders for the section that were non-directed orders, and the percentages of total... aspects of the broker's or dealer's relationship with each venue identified pursuant to paragraph (a)(1...

17 CFR 242.100 - Preliminary note; definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation M § 242.100 Preliminary note; definitions. (a) Preliminary note: Any transaction or series of transactions, whether or not effected pursuant to the provisions of Regulation M (§§ 242.100-242.105 of this...

Resisting Social Justice in Leadership Preparation Programs: Mechanisms that Subvert

ERIC Educational Resources Information Center

Hernandez, Frank; McKenzie, Kathryn Bell

2010-01-01

It is well documented that the achievement gap between affluent students and economically disadvantaged students and between White students and students of color continues to widen. In addition to these achievement gaps, marginalizing practices are often imbedded in the structures of schooling. These challenges require educational leadership…

Mental Health in Schools: Moving in New Directions

ERIC Educational Resources Information Center

Adelman, Howard S.; Taylor, Linda

2012-01-01

Current approaches to mental health in school tend to overemphasize individually prescribed treatment to the detriment of prevention programs. Moreover, they are implemented as another fragmented set of interventions, and this contributes to the continuing marginalization of student and learning supports. Finally, when the focus is on individuals'…

Capturing Visual Metaphors and Tales: Innovative or Elusive?

ERIC Educational Resources Information Center

Elliot, Dely Lazarte; Reid, Kate; Baumfield, Vivienne

2017-01-01

Despite the exponential growth of visual research in the social sciences in the last three decades, continuing empirical enquiries are arguably more relevant than ever. Earlier research employed visual methods primarily to investigate distinct cultural practices, often seeking the views of marginalized, challenging or hard-to-reach participants.…

Applying Indigenizing Principles of Decolonizing Methodologies in University Classrooms

ERIC Educational Resources Information Center

Louie, Dustin William; Pratt, Yvonne Poitras; Hanson, Aubrey Jean; Ottmann, Jacqueline

2017-01-01

This case study examines ongoing work to Indigenize education programs at one Canadian university. The history of the academy in Canada has been dominated by Western epistemologies, which have devalued Indigenous ways of knowing and set the grounds for continued marginalization of Indigenous students, communities, cultures, and histories. We argue…

The NEST-NNEST Divide and Teacher Identity Construction in Hong Kong Schools

ERIC Educational Resources Information Center

Trent, John

2016-01-01

Despite widespread acknowledgement of the contribution of nonnative English-speaking teachers (NNESTs) to teaching English as an international language, the privileging of native English-speaking teachers (NESTs) and native-speaker competency, and concomitant marginalization of NNESTs, continues in many countries. To investigate and problematize…

Developing Culturally Responsive Mathematics Teachers: Secondary Teachers' Evolving Conceptions of Knowing Students

ERIC Educational Resources Information Center

Parker, Frieda; Bartell, Tonya Gau; Novak, Jodie D.

2017-01-01

Research advances in teaching, learning, curriculum, and assessment have not changed the continued underperformance of marginalized students in mathematics education. Culturally responsive teaching is a means of addressing the needs of these students. It is sometimes challenging, however, to convince secondary mathematics teachers about the…

Graphic Narratives: Cognitive and Pedagogical Choices for Implementation in the English Language Arts Classroom

ERIC Educational Resources Information Center

Dulaney, Margaret Anne

2012-01-01

There is little empirical research that investigates the implementation of graphic narratives into the English language arts classroom, subsequently leading to misperceptions and misconceptions about their educative uses. Despite sequential arts' long history, graphic narratives continue to experience a marginalized existence within the…

Geochemical evidences of methane hydrate dissociation in Alaskan Beaufort Margin during Holocene

NASA Astrophysics Data System (ADS)

Uchida, M.; Rella, S.; Kubota, Y.; Kumata, H.; Mantoku, K.; Nishino, S.; Itoh, M.

2017-12-01

Alaskan Beaufort margin bear large abundances of sub-sea and permafrost methane hydrate[Ruppel, 2016]. During the Last Glacial, previous reported direct and indirect evidences accumulated from geochemical data from marginal sea sediment suggests that methane episodically released from hydrate trapped in the seafloor sediments[Kennett et al., 2000; Uchida et al., 2006, 2008; Cook et al, 2011]. Here we analyzed stable isotopes of foraminifera and molecular marker derived from the activity of methanotrophic bacteria from piston cores collected by the 2010 R/V Mirai cruise in Alaskan Beaufort Margin. Our data showed highly depleted 13C compositions of benthic foraminifera, suggesting indirect records of enhanced incorporation of 13C-depleted CO2 formed by methanotrophic process that use 12C-enriched methane as their main source of carbon. This is the first evidence of methane hydrate dissociation in Alaskan margin. Here we discussed timing of signals of methane dissociation with variability of sea ice and intermediate Atlantic water temperature. The dissociation of methane hydrate in the Alaskan Margin may be modulated by Atlantic warm intermediate water warming. Our results suggest that Arctic marginal regions bearing large amount methane hydrate may be a profound effect on future warming climate changes.

Informing practice regarding marginalization: the application of the Koci Marginality Index.

PubMed

Koci, Anne Floyd; McFarlane, Judith; Nava, Angeles; Gilroy, Heidi; Maddoux, John

2012-12-01

The 49th World Health Assembly of the World Health Organization (WHO) declared violence as the leading worldwide public health problem with a focus on the increase in the incidence of injuries to women. Violence against women is an international epidemic with specific instruments required to measure the impact on women's functioning. This article describes the application of the Koci Marginality Index (KMI), a 5-item scale to measure marginality, to the baseline data of a seven-year prospective study of 300 abused women: 150 first time users of a shelter and 150 first time applicants for a protection order from the justice system. Validity and reliability of the Koci Marginality Index and its usefulness for best clinical practice and for policy decisions for abused women's health are discussed. The 49th World Health Assembly of the World Health Organization (WHO) declared violence as the leading worldwide public health problem and focused on the increase in the incidence of injuries to women (Krug et al., 2002 ). Violence against women in the form of intimate partner violence (IPV) is costly in terms of dollars and health. In the United States in 2003, estimated costs of IPV approached $8.3 billion (Centers for Disease Control and Prevention [CDC], 2011). Outcomes related to severity of IPV vary but in 2003 victims suffering severe IPV lost nearly 8 million days of paid work, and greater than 5 million days of household productivity annually (CDC, 2011). Besides the evident financial cost of IPV, research confirms that exposure to IPV impacts a woman's health immediately and in the long-term (Breiding, Black, & Ryan, 2008 ; Campbell, 2002 ; CDC, 2011). Such sequela adversely affect the health of women and may increase their marginalization, a concept akin to isolation that may further increase negative effects on health outcomes. Immigrant women are at high risk for IPV (Erez, 2002 ) and those without documentation are at higher risk for marginalization (Montalvo-Liendo, Koci, McFarlane, Nava, Gilroy, & Maddoux, 2012). This paper explores marginality with reference to IPV and the development and application of an instrument to measure marginality.

ICE AND DEBRIS IN THE FRETTED TERRAIN, MARS.

USGS Publications Warehouse

Lucchitta, Baerbel K.

1984-01-01

Viking moderate- and high-resolution images along the northern highland margin were studied monoscopically and stereoscopically to contribute to an understanding of the development of fretted terrain. Results support the hypothesis that the fretting process involved flow facilitated by interstitial ice. The process apparently continued for a long period of time, and debris-apron formation shaped the fretted terrain in the past as well as the present. Interstitial ice in debris aprons is most likely derived from ground ice obtained by sapping or scarp collapse. Debris aprons could have been removed by sublimation if they consisted mostly of ice, or by deflation if they consisted mostly of debris. To remove the debris, wind erosion was either very intense early in martian history, or was intermittent, perhaps owing to climatic cycles.

Using Iterative Repair to Increase the Responsiveness of Planning and Scheduling for Autonomous Spacecraft

NASA Technical Reports Server (NTRS)

Chien, Steve; Knight, Russell; Stechert, Andre; Sherwood, Rob; Rabideau, Gregg

1998-01-01

An autonomous spacecraft must balance long-term and short-term considerations. It must perform purposeful activities that ensure long-term science and engineering goals are achieved and ensure that it maintains positive resource margins. This requires planning in advance to avoid a series of shortsighted decisions that can lead to failure, However, it must also respond in a timely fashion to a somewhat dynamic and unpredictable environment. Thus, spacecraft plans must often be modified due to fortuitous events such as early completion of observations and setbacks such as failure to acquire a guidestar for a science observation. This paper describes the use of iterative repair to support continuous modification and updating of a current working plan in light of changing operating context.

MIZEX: A Program for Mesoscale Air-Ice-Ocean Interaction Experiments in Arctic Marginal Ice Zones. VIII. A Science Plan for a Winter Marginal Ice Zone Experiment in the Fram Strait/Greenland Sea: 1987/89,

DTIC Science & Technology

1986-04-01

forward modeling, with the pa- be telemetered via the ARGOS system for real - rameter changes needed to bring the predictions time evaluation, and the...integrated en ’i- rtinnental measurement svs fern. quisition system to the Winter MIZEX in I-ram To control and direct the experiment, real - time Strait...to measure, under- Electromagnetic sensing via aircraft and satellites stand, and model: will be employed in real time to identify eddy " Changes in

Impact of adhesive and photoactivation method on sealant integrity and polymer network formation.

PubMed

Borges, Boniek Castillo Dutra; Pereira, Fabrício Lopes da Rocha; Alonso, Roberta Caroline Bruschi; Braz, Rodivan; Montes, Marcos Antônio Japiassú Resende; Pinheiro, Isauremi Vieira de Assunção; Santos, Alex José Souza dos

2012-01-01

We evaluated the influence of photoactivation method and hydrophobic resin (HR) application on the marginal and internal adaptation, hardness (KHN), and crosslink density (CLD) of a resin-based fissure sealant. Model fissures were created in bovine enamel fragments (n = 10) and sealed using one of the following protocols: no adhesive system + photoactivation of the sealant using continuous light (CL), no adhesive system + photoactivation of the sealant using the soft-start method (SS), HR + CL, or HR + SS. Marginal and internal gaps and KHN were assessed after storage in water for 24 h. The CLD was indirectly assessed by repeating the KHN measurement after 24 h of immersion in 100% ethanol. There was no difference among the samples with regard to marginal or internal adaptation. The KHN and CLD were similar for samples cured using either photoactivation method. Use of a hydrophobic resin prior to placement of fissure sealants and curing the sealant using the soft-start method may not provide any positive influence on integrity or crosslink density.

Photometric studies of two solar type marginal contact binaries in the Small Magellanic Cloud

NASA Astrophysics Data System (ADS)

Shanti Priya, Devarapalli; Rukmini, Jagirdar

2018-04-01

Using the Optical Gravitational Lensing Experiment catalogue, two contact binaries were studied using data in the V and I bands. The photometric solutions for the V and I bands are presented for two contact binaries OGLE 003835.24-735413.2 (V1) and OGLE 004619.65-725056.2 (V2) in Small Maglellanic Cloud. The presented light curves are analyzed using the Wilson-Devinney code. The results show that the variables are in good thermal and marginal geometrical contact with features like the O’Connell effect in V1. The absolute dimensions are estimated and its dynamical evolution is inferred. They tend to be solar type marginal contact binaries. The 3.6-m Devasthal Optical Telescope and the 4.0-m International Liquid Mirror Telescope of the Aryabhatta Research Institute of Observational Sciences (ARIES, Nainithal) can facilitate the continuous monitoring of such kind of objects which will help in finding the reasons behind their period changes and their impact on the evolution of the clusters.

Effects of Medicare payment reform: evidence from the home health interim and prospective payment systems.

PubMed

Huckfeldt, Peter J; Sood, Neeraj; Escarce, José J; Grabowski, David C; Newhouse, Joseph P

2014-03-01

Medicare continues to implement payment reforms that shift reimbursement from fee-for-service toward episode-based payment, affecting average and marginal payment. We contrast the effects of two reforms for home health agencies. The home health interim payment system in 1997 lowered both types of payment; our conceptual model predicts a decline in the likelihood of use and costs, both of which we find. The home health prospective payment system in 2000 raised average but lowered marginal payment with theoretically ambiguous effects; we find a modest increase in use and costs. We find little substantive effect of either policy on readmissions or mortality. Copyright © 2014 Elsevier B.V. All rights reserved.

Fault-tolerant locomotion of the hexapod robot.

PubMed

Yang, J M; Kim, J H

1998-01-01

In this paper, we propose a scheme for fault detection and tolerance of the hexapod robot locomotion on even terrain. The fault stability margin is defined to represent potential stability which a gait can have in case a sudden fault event occurs to one leg. Based on this, the fault-tolerant quadruped periodic gaits of the hexapod walking over perfectly even terrain are derived. It is demonstrated that the derived quadruped gait is the optimal one the hexapod can have maintaining fault stability margin nonnegative and a geometric condition should be satisfied for the optimal locomotion. By this scheme, when one leg is in failure, the hexapod robot has the modified tripod gait to continue the optimal locomotion.

Effects of Medicare Payment Reform: Evidence from the Home Health Interim and Prospective Payment Systems

PubMed Central

Huckfeldt, Peter J; Sood, Neeraj; Escarce, José J; Grabowski, David C; Newhouse, Joseph P

2014-01-01

Medicare continues to implement payment reforms that shift reimbursement from fee-for-service towards episode-based payment, affecting average and marginal payment. We contrast the effects of two reforms for home health agencies. The Home Health Interim Payment System in 1997 lowered both types of payment; our conceptual model predicts a decline in the likelihood of use and costs, both of which we find. The Home Health Prospective Payment System in 2000 raised average but lowered marginal payment with theoretically ambiguous effects; we find a modest increase in use and costs. We find little substantive effect of either policy on readmissions or mortality. PMID:24395018

Uplift history of a transform continental margin revealed by the stratigraphic record: The case of the Agulhas transform margin along the Southern African Plateau

NASA Astrophysics Data System (ADS)

Baby, Guillaume; Guillocheau, François; Boulogne, Carl; Robin, Cécile; Dall'Asta, Massimo

2018-04-01

The south and southeast coast of southern Africa (from 28°S to 33°S) forms a high-elevated transform passive margin bounded to the east by the Agulhas-Falkland Fracture Zone (AFFZ). We analysed the stratigraphic record of the Outeniqua and Durban (Thekwini) Basins, located on the African side of the AFFZ, to determine the evolution of these margins from the rifting stage to present-day. The goal was to reconstruct the strike-slip evolution of the Agulhas Margin and the uplift of the inland high-elevation South African Plateau. The Agulhas transform passive margin results from four successive stages: Rifting stage, from Late Triassic to Early Cretaceous ( 200?-134 Ma), punctuated by three successive rifting episodes related to the Gondwana breakup; Wrench stage (134-131 Ma), evidenced by strike- and dip-slip deformations increasing toward the AFFZ; Active transform margin stage (131-92 Ma), during which the Falkland/Malvinas Plateau drifts away along the AFFZ, with an uplift of the northeastern part of the Outeniqua Basin progressively migrating toward the west; Thermal subsidence stage (92-0 Ma), marked by a major change in the configuration of the margin (onset of the shelf-break passive margin morphology). Two main periods of uplift were documented during the thermal subsidence stage of the Agulhas Margin: (1) a 92 Ma short-lived margin-scale uplift, followed by a second one at 76 Ma located along the Outeniqua Basin and; (2) a long-lasting uplift from 40 to 15 Ma limited to the Durban (Thekwini) Basin. This suggests that the South African Plateau is an old Upper Cretaceous relief (90-70 Ma) reactivated during Late Eocene to Early Miocene times (40-15 Ma).

Surgeon Contribution to Hospital Bottom Line

PubMed Central

Resnick, Andrew S.; Corrigan, Diane; Mullen, James L.; Kaiser, Larry R.

2005-01-01

Objective: We hypothesized that surgeon productivity is directly related to hospital operating margin, but significant variation in margin contribution exists between specialties. Summary Background Data: As the independent practitioner becomes an endangered species, it is critical to better understand the surgeon's importance to a hospital's bottom line. An appreciation of surgeon contribution to hospital profitability may prove useful in negotiations relating to full-time employment or other models. Methods: Surgeon total relative value units (RVUs), a measure of productivity, were collected from operating room (OR) logs. Annual hospital margin per specialty was provided by hospital finance. Hospital margin data were normalized by dividing by a constant such that the highest relative hospital margin (RHM) in fiscal year 2004 expressed as margin units (mu) was 1 million mu. For each specialty, data analyzed included RHM/OR HR, RHM/case, and RHM/RVU. Results: Thoracic (34.55 mu/RVU) and transplant (25.13 mu/RVU) were the biggest contributors to hospital margin. Plastics (−0.57 mu/RVU), maxillofacial (1.41 mu/RVU), and gynecology (1.66 mu/RVU) contributed least to hospital margin. Relative hospital margin per OR HR for transplant slightly exceeded thoracic (275.74 mu vs 233.94 mu) at the top and plastics and maxillofacial contributed the least (−3.83 mu/OR HR vs 9.36 mu/OR HR). Conclusions: Surgeons contribute significantly to hospital margin with certain specialties being more profitable than others. Payer mix, the penetration of managed care, and negotiated contracts as well as a number of other factors all have an impact on an individual hospital's margin. Surgeons should be fully cognizant of their significant influence in the marketplace. PMID:16192813

Lower Crustal Strength Controls on Melting and Serpentinization at Magma-Poor Margins: Potential Implications for the South Atlantic

NASA Astrophysics Data System (ADS)

Ros, Elena; Pérez-Gussinyé, Marta; Araújo, Mario; Thoaldo Romeiro, Marco; Andrés-Martínez, Miguel; Morgan, Jason P.

2017-12-01

Rifted continental margins may present a predominantly magmatic continent-ocean transition (COT), or one characterized by large exposures of serpentinized mantle. In this study we use numerical modeling to show the importance of the lower crustal strength in controlling the amount and onset of melting and serpentinization during rifting. We propose that the relative timing between both events controls the nature of the COT. Numerical experiments for half-extension velocities <=10 mm/yr suggest there is a genetic link between margin tectonic style and COT nature that strongly depends on the lower crustal strength. Our results imply that very slow extension velocities (< 5 mm/yr) and a strong lower crust lead to margins characterized by large oceanward dipping faults, strong syn-rift subsidence and abrupt crustal tapering beneath the continental shelf. These margins can be either narrow symmetric or asymmetric and present a COT with exhumed serpentinized mantle underlain by some magmatic products. In contrast, a weak lower crust promotes margins with a gentle crustal tapering, small faults dipping both ocean- and landward and small syn-rift subsidence. Their COT is predominantly magmatic at any ultra-slow extension velocity and perhaps underlain by some serpentinized mantle. These margins can also be either symmetric or asymmetric. Our models predict that magmatic underplating mostly underlies the wide margin at weak asymmetric conjugates, whereas the wide margin is mainly underlain by serpentinized mantle at strong asymmetric margins. Based on this conceptual template, we propose different natures for the COTs in the South Atlantic.

The Effects of Marginal Deviations on Behavioral Development.

PubMed

Caprara, Gian Vittorio; Dodge, Kenneth A; Pastorelli, Concetta; Zelli, Arnaldo

2006-01-01

This investigation was conceptually framed within the theory of marginal deviations (Caprara & Zimbardo, 1996) and sought evidence for the general hypothesis that some children who initially show marginal behavioral problems may, over time, develop more serious problems depending partly on other personal and behavioral characteristics. To this end, the findings of two studies conducted, respectively, with American elementary school children and Italian middle school students are reviewed. These two studies show that hyperactivity, cognitive difficulties, low special preference, and lack of prosocial behavior increase a child's risk for growth in aggressive behavior over several school years. More importantly, they also show that equivalent levels of these risk factors have a greater impact on the development of children who, early on, were marginally aggressive.

Modelling shoal margin collapses and their morphodynamic effect on channels and shoals in a sandy estuary

NASA Astrophysics Data System (ADS)

van Dijk, W. M.; Mastbergen, D. R.; Van der Werf, J. J.; Leuven, J.; Kleinhans, M. G.

2017-12-01

Channel bank failure and collapses of shoal margins due to flow slides have been recorded in Dutch estuaries for the past 200 years. The effects of these collapses on the morphodynamics of estuaries are unknown, but could potentially increase the dynamics of channel-shoal interactions by causing perturbations of up to a million cubic meters per event, which could impact habitats and navigability. The processes of shoal margin collapses are currently not included in numerical morphodynamic models. The objectives of this study are to investigate where shoal margins collapses typically occur, what their dimensions are, and to model how shoal margin collapses affect the morphodynamics at the channel-shoal scale. We identified 300 shoal margin collapses from bathymetry data of the Western Scheldt estuary for the period 1959-2015, and found that the shape of a shoal margin collapse is well represented by 1/3 of an ellipsoid, and that its volume has a log-normal distribution with an average of 100,000 m3. We implemented a parameterization for shoal margin collapses and tested their effects on morphodynamics in a Delft3D numerical model schematization of the Western Scheldt estuary. Three sets of scenarios were analyzed for near-field morphodynamics and far-field effects on flow pattern and channel-bar morphology: 1) an observed single shoal margin collapse of 2014, 2) collapses on various locations that are susceptible to collapses, and 3) our novel stochastic model producing collapses over a time span of a decade. Results show that single shoal margin collapses only affect the local dynamics in longitudinal direction and dampen out within a year when the collapse is small. When larger disturbances reach the seaward or landward sill at tidal channel junctions over a longer time span, the bed elevation at the sill increases on average and decrease the hydraulic geometry of the channel junctions. The extent of far-field effects is sensitive to the grain-size of the deposit, where finer sediments are transported further away. The location of the deposit across the channel matters for disturbing the region around the collapse, where sediment transport is highest for the strongest residual current. These results imply that disturbances caused by dredging and dumping may likewise affect the dynamics of channel junctions.

Marginal biotin deficiency can be induced experimentally in humans using a cost-effective outpatient design.

PubMed

Stratton, Shawna L; Henrich, Cindy L; Matthews, Nell I; Bogusiewicz, Anna; Dawson, Amanda M; Horvath, Thomas D; Owen, Suzanne N; Boysen, Gunnar; Moran, Jeffery H; Mock, Donald M

2012-01-01

To date, marginal, asymptomatic biotin deficiency has been successfully induced experimentally by the use of labor-intensive inpatient designs requiring rigorous dietary control. We sought to determine if marginal biotin deficiency could be induced in humans in a less expensive outpatient design incorporating a self-selected, mixed general diet. We sought to examine the efficacy of three outpatient study designs: two based on oral avidin dosing and one based on a diet high in undenatured egg white for a period of 28 d. In study design 1, participants (n = 4; 3 women) received avidin in capsules with a biotin binding capacity of 7 times the estimated dietary biotin intake of a typical self-selected diet. In study design 2, participants (n = 2; 2 women) received double the amount of avidin capsules (14 times the estimated dietary biotin intake). In study design 3, participants (n = 5; 3 women) consumed egg-white beverages containing avidin with a biotin binding capacity of 7 times the estimated dietary biotin intake. Established indices of biotin status [lymphocyte propionyl-CoA carboxylase activity; urinary excretion of 3-hydroxyisovaleric acid, 3-hydroxyisovaleryl carnitine (3HIA-carnitine), and biotin; and plasma concentration of 3HIA-carnitine] indicated that study designs 1 and 2 were not effective in inducing marginal biotin deficiency, but study design 3 was as effective as previous inpatient study designs that induced deficiency by egg-white beverage. Marginal biotin deficiency can be induced experimentally by using a cost-effective outpatient design by avidin delivery in egg-white beverages. This design should be useful to the broader nutritional research community.

Ice Sheet History from Antarctic Continental Margin Sediments: The ANTOSTRAT Approach

USGS Publications Warehouse

Barker, P.F.; Barrett, P.J.; Camerlenghi, A.; Cooper, A. K.; Davey, F.J.; Domack, E.W.; Escutia, C.; Kristoffersen, Y.; O'Brien, P.E.

1998-01-01

The Antarctic Ice Sheet is today an important part of the global climate engine, and probably has been so for most of its long existence. However, the details of its history are poorly known, despite the measurement and use, over two decades, of low-latitude proxies of ice sheet volume. An additional way of determining ice sheet history is now available, based on understanding terrigenous sediment transport and deposition under a glacial regime. It requires direct sampling of the prograded wedge of glacial sediments deposited at the Antarctic continental margin (and of derived sediments on the continental rise) at a small number of key sites, and combines the resulting data using numerical models of ice sheet development. The new phase of sampling is embodied mainly in a suite of proposals to the Ocean Drilling Program, generated by separate regional proponent groups co-ordinated through ANTOSTRAT (the Antarctic Offshore Acoustic Stratigraphy initiative). The first set of margin sites has now been drilled as ODP Leg 178 to the Antarctic Peninsula margin, and a first, short season of inshore drilling at Cape Roberts, Ross Sea, has been completed. Leg 178 and Cape Roberts drilling results are described briefly here, together with an outline of key elements of the overall strategy for determining glacial history, and of the potential contributions of drilling other Antarctic margins investigated by ANTOSTRAT. ODP Leg 178 also recovered continuous ultra-high-resolution Holocene biogenic sections at two sites within a protected, glacially-overdeepened basin (Palmer Deep) on the inner continental shelf of the Antarctic Peninsula. These and similar sites from around the Antarctic margin are a valuable resource when linked with ice cores and equivalent sections at lower latitude sites for studies of decadal and millenial-scale climate variation.

Permian plate margin volcanism and tuffs in adjacent basins of west Gondwana: Age constraints and common characteristics

NASA Astrophysics Data System (ADS)

López-Gamundí, Oscar

2006-12-01

Increasing evidence of Permian volcanic activity along the South American portion of the Gondwana proto-Pacific margin has directed attention to its potential presence in the stratigraphic record of adjacent basins. In recent years, tuffaceous horizons have been identified in late Early Permian-through Middle Permian (280-260 Ma) sections of the Paraná Basin (Brazil, Paraguay, and Uruguay). Farther south and closer to the magmatic tract developed along the continental margin, in the San Rafael and Sauce Grande basins of Argentina, tuffs are present in the Early to Middle Permian section. This tuff-rich interval can be correlated with the appearance of widespread tuffs in the Karoo Basin. Although magmatic activity along the proto-Pacific plate margin was continuous during the Late Paleozoic, Choiyoi silicic volcanism along the Andean Cordillera and its equivalent in Patagonia peaked between the late Early Permian and Middle Permian, when extensive rhyolitic ignimbrites and consanguineous airborne tuffaceous material erupted in the northern Patagonian region. The San Rafael orogenic phase (SROP) interrupted sedimentation along the southwestern segment of the Gondwana margin (i.e., Frontal Cordillera, San Rafael Basin), induced cratonward thrusting (i.e., Ventana and Cape foldbelts), and triggered accelerated subsidence in the adjacent basins (Sauce Grande and Karoo) located inboard of the deformation front. This accelerated subsidence favored the preservation of tuffaceous horizons in the syntectonic successions. The age constraints and similarities in composition between the volcanics along the continental margin and the tuffaceous horizons in the San Rafael, Sauce Grande, Paraná, and Karoo basins strongly suggest a genetic linkage between the two episodes. Radiometric ages from tuffs in the San Rafael, Paraná, and Karoo basins indicate an intensely tuffaceous interval between 280 and 260 Ma.

Automatic detection of Floating Ice at Antarctic Continental Margin from Remotely Sensed Image with Object-oriented Matching

NASA Astrophysics Data System (ADS)

Zhao, Z.

2011-12-01

Changes in ice sheet and floating ices around that have great significance for global change research. In the context of global warming, rapidly changing of Antarctic continental margin, caving of ice shelves, movement of iceberg are all closely related to climate change and ocean circulation. Using automatic change detection technology to rapid positioning the melting Region of Polar ice sheet and the location of ice drift would not only strong support for Global Change Research but also lay the foundation for establishing early warning mechanism for melting of the polar ice and Ice displacement. This paper proposed an automatic change detection method using object-based segmentation technology. The process includes three parts: ice extraction using image segmentation, object-baed ice tracking, change detection based on similarity matching. An approach based on similarity matching of eigenvector is proposed in this paper, which used area, perimeter, Hausdorff distance, contour, shape and other information of each ice-object. Different time of LANDSAT ETM+ data, Chinese environment disaster satellite HJ1B date, MODIS 1B date are used to detect changes of Floating ice at Antarctic continental margin respectively. We select different time of ETM+ data(January 7, 2003 and January 16, 2003) with the area around Antarctic continental margin near the Lazarev Bay, which is from 70.27454853 degrees south latitude, longitude 12.38573410 degrees to 71.44474167 degrees south latitude, longitude 10.39252222 degrees,included 11628 sq km of Antarctic continental margin area, as a sample. Then we can obtain the area of floating ices reduced 371km2, and the number of them reduced 402 during the time. In addition, the changes of all the floating ices around the margin region of Antarctic within 1200 km are detected using MODIS 1B data. During the time from January 1, 2008 to January 7, 2008, the floating ice area decreased by 21644732 km2, and the number of them reduced by 83080. The results show that the object-based information extraction algorithm can obtain more precise details of a single object, while the change detection method based on similarity matching can effectively tracking the change of floating ice.

Marginal Groups in Marginal Times: Gypsy and Traveller Parents and Home Education in England, UK

ERIC Educational Resources Information Center

Bhopal, Kalwant; Myers, Martin

2016-01-01

This article examines the experiences of home education for Gypsy and Traveller groups in England, UK. We argue that home education is perceived in a particular historical "moment" characterised in the media and more generally throughout society by "risk". Against this backdrop this article considers Gypsy and Traveller…

The Marginal Teacher: A Step-by-Step Guide to Fair Procedures for Identification and Dismissal

ERIC Educational Resources Information Center

Lawrence, C. Edward

2005-01-01

This third edition offers timely solutions for successfully dealing with marginal teachers. Lawrence illustrates the proper actions that principals should integrate into the evaluation processes to successfully gather documentation to help improve or terminate an ineffective teacher. Complete with tools and resources to streamline the evaluation…

Deglaciation-induced uplift of the Petermann glacier ice margin observed with InSAR

NASA Astrophysics Data System (ADS)

Lu, Q.; Amelung, F.; Wdowinski, S.

2016-12-01

The Greenland ice sheet is rapidly shrinking with the fastest retreat and thinning occurring at the ice sheet margin and near the outlet glaciers. The changes of the ice mass cause an elastic response of the bedrock. Ice mass loss during the summer months is associated with uplift, whereas ice mass increase during the winter months is associated with subsidence.The German TerraSAR-X and TanDEM-X satellites have systematically observed selected sites along the Greenland Petermann ice sheet margin since summer 2012. Here we present ground deformation observations obtained using an InSAR time-series approach based on small baseline interferograms. We observed rapid deglaciation-induced uplift on naked bedrock near the Petermann glacier ice margin Deformation observed by InSAR is consistent with GPS vertical observations. The time series displacement data reveal not only net uplift but also the seasonal variations. There is no strong relative between displacement changes and SMB ice mass change. The seasonal variations in local area may caused by both nearby SMB changes and ice dynamic changes.