Claims for Unabsorbed Overhead on Defense Contracts.

DTIC Science & Technology

1985-09-01

coat which, under the provisions of any pertinent law, regulation, or contract, cannot be included in prices, cost reimbureements , or settlements...ruled that the contractor was due some reimbursement . " - Allegheny appealed the contracting officer’s determination a second time questioning how much...amount of reimbursement . The final opinion also added the cost that was substantiated for replacement of operators and make-up pay. Therefore, the

Study of correlation between maternal fatigue and uterine contraction pattern in the active phase of labour.

PubMed

Ebrahimzadeh, Samira; Golmakani, Nahid; Kabirian, Maryam; Shakeri, Mohhamad T

2012-06-01

To evaluate the correlation between maternal fatigue and uterine contraction pattern at the beginning of the active phase of labour. Fatigue is one of the most common complaints in pregnant women that often continues until delivery. Maternal fatigue prolongs the labour process and increases the rate of cesarian section. Studies on the pattern of uterine contractions have shown that the length of the fall time is longer in prolonged labours than in normal deliveries. A cross-sectional study. This study was conducted on 100 primiparous women who were referred to Ommolbanin Hospital (Mashhad, Iran) in 2011. Maternal fatigue was assessed at the beginning of the active phase of labour. Then, the pattern of uterine contractions was monitored for 30 minutes by an external tocodynamometer. The F/R ratio was determined by measuring the time for a contraction to return to its baseline from its peak and the time for a contraction to rise to its peak. The data were analysed by chi-square and anova tests. The results showed that there was a significant relationship between maternal fatigue and uterine contraction pattern. The F/R ratio was increased with increase in fatigue severity. Fatigue causes changes in the pattern of uterine contractions. The return time of a contraction from its peak to its baseline (fall) is increased with increase in fatigue severity. Offering strategies to prevent tiredness and reduce the related fatigue complications. © 2012 Blackwell Publishing Ltd.

48 CFR 2452.216-74 - Distribution of award fee.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Evaluation Period: [insert time period] Available Award Fee: [insert dollar amount] (b) In the event of...-rata distribution associated with evaluation period activities or events as determined by the Fee... 2416.406(e)(3), add paragraph (c): (c) The contract clauses required for cost-reimbursement contracts...

48 CFR 2452.216-74 - Distribution of award fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Evaluation Period: [insert time period] Available Award Fee: [insert dollar amount] (b) In the event of...-rata distribution associated with evaluation period activities or events as determined by the Fee... 2416.406(e)(3), add paragraph (c): (c) The contract clauses required for cost-reimbursement contracts...

48 CFR 2452.216-74 - Distribution of award fee.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Evaluation Period: [insert time period] Available Award Fee: [insert dollar amount] (b) In the event of...-rata distribution associated with evaluation period activities or events as determined by the Fee... 2416.406(e)(3), add paragraph (c): (c) The contract clauses required for cost-reimbursement contracts...

48 CFR 2452.216-74 - Distribution of award fee.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Evaluation Period: [insert time period] Available Award Fee: [insert dollar amount] (b) In the event of...-rata distribution associated with evaluation period activities or events as determined by the Fee... 2416.406(e)(3), add paragraph (c): (c) The contract clauses required for cost-reimbursement contracts...

48 CFR 2452.216-74 - Distribution of award fee.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Evaluation Period: [insert time period] Available Award Fee: [insert dollar amount] (b) In the event of...-rata distribution associated with evaluation period activities or events as determined by the Fee... 2416.406(e)(3), add paragraph (c): (c) The contract clauses required for cost-reimbursement contracts...

48 CFR 552.243-71 - Equitable Adjustments.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Markups. (3) Change to the time for completion specified in the contract. (e) Direct costs. The Contractor... contract regarding the Contractor's project schedule. (h) Markups. For each firm whose direct costs are... applicable, a bond rate and insurance rate. Markups shall be determined and applied as follows: (1) Overhead...

48 CFR 48.104-1 - Determining sharing period.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., based on planning and programming or production documentation at the time the VECP is accepted. The.... (c) For engineering-development contracts and contracts containing low-rate-initial-production or early production units, the end of the sharing period is based not on a calendar date, but on acceptance...

48 CFR 48.104-1 - Determining sharing period.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., based on planning and programming or production documentation at the time the VECP is accepted. The.... (c) For engineering-development contracts and contracts containing low-rate-initial-production or early production units, the end of the sharing period is based not on a calendar date, but on acceptance...

48 CFR 48.104-1 - Determining sharing period.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., based on planning and programming or production documentation at the time the VECP is accepted. The.... (c) For engineering-development contracts and contracts containing low-rate-initial-production or early production units, the end of the sharing period is based not on a calendar date, but on acceptance...

48 CFR 48.104-1 - Determining sharing period.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., based on planning and programming or production documentation at the time the VECP is accepted. The.... (c) For engineering-development contracts and contracts containing low-rate-initial-production or early production units, the end of the sharing period is based not on a calendar date, but on acceptance...

Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner

PubMed Central

Sanchez, Otto A.; Copenhaver, Elizabeth A.; Chance, Marti A.; Fowler, Michael J.; Towse, Theodore F.; Kent-Braun, Jane A.

2011-01-01

The purpose of this study was to determine whether there are differences in postisometric contraction blood volume and oxygenation responses among groups of type 2 diabetes mellitus (T2DM), obese, and lean individuals detectable using MRI. Eight T2DM patients were individually matched by age, sex, and race to non-T2DM individuals with similar body mass index (obese) and lean subjects. Functional MRI was performed using a dual-gradient-recalled echo, echo-planar imaging sequence with a repetition time of 1 s and at two echo times (TE = 6 and 46 ms). Data were acquired before, during, and after 10-s isometric dorsiflexion contractions performed at 50 and 100% of maximal voluntary contraction (MVC) force. MRI signal intensity (SI) changes from the tibialis anterior and extensor digitorum longus muscles were plotted as functions of time for each TE. From each time course, the difference between the minimum and the maximum postcontraction SI (ΔSI) were determined for TE = 6 ms (ΔSI6) and TE = 46 ms (ΔSI46), reflecting variations in blood volume and oxyhemoglobin saturation, respectively. Following 50% MVC contractions, the mean postcontraction ΔSI6 values were similar in the three groups. Following MVC only, and in the EDL muscle only, T2DM and obese participants had ∼56% lower ΔSI6 than the lean individuals. Also following MVC only, the ΔSI46 response in the EDL was lower in T2DM subjects than in lean individuals. These data suggest that skeletal muscle small vessel impairment occurs in T2DM and body mass index-matched subjects, in muscle-specific and contraction intensity-dependent manners. PMID:21572006

48 CFR 32.205 - Procedures for offeror-proposed commercial contract financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... those financing payments and add it to the proposed price to determine the evaluated price for each... must calculate the time value of proposal-specified contract financing arrangements using as the.... Appendix C is updated yearly, and is available from the Office of Economic Policy in the Office of...

48 CFR 32.205 - Procedures for offeror-proposed commercial contract financing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... those financing payments and add it to the proposed price to determine the evaluated price for each... must calculate the time value of proposal-specified contract financing arrangements using as the.... Appendix C is updated yearly, and is available from the Office of Economic Policy in the Office of...

48 CFR 32.205 - Procedures for offeror-proposed commercial contract financing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... those financing payments and add it to the proposed price to determine the evaluated price for each... must calculate the time value of proposal-specified contract financing arrangements using as the.... Appendix C is updated yearly, and is available from the Office of Economic Policy in the Office of...

48 CFR 32.205 - Procedures for offeror-proposed commercial contract financing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... those financing payments and add it to the proposed price to determine the evaluated price for each... must calculate the time value of proposal-specified contract financing arrangements using as the.... Appendix C is updated yearly, and is available from the Office of Economic Policy in the Office of...

48 CFR 32.205 - Procedures for offeror-proposed commercial contract financing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... those financing payments and add it to the proposed price to determine the evaluated price for each... must calculate the time value of proposal-specified contract financing arrangements using as the.... Appendix C is updated yearly, and is available from the Office of Economic Policy in the Office of...

7 CFR 273.10 - Determining household eligibility and benefit levels.

Code of Federal Regulations, 2010 CFR

2010-01-01

... contract or self-employment, derive their annual income in a period of time shorter than 1 year shall have..., and other self-employed households. However, these provisions do not apply to migrant or seasonal farmworkers. The procedures for averaging self-employed income are described in § 273.11. Contract income...

30 CFR 1206.301 - Value basis for royalty computation.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) The gross value for royalty purposes shall be the sale or contract unit price times the number of units sold, Provided, however, That where the authorized officer determines: (1) That a contract of sale... whole or in part upon considerations other than the value of the commodities, or (2) That no bona fide...

30 CFR 1206.301 - Value basis for royalty computation.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) The gross value for royalty purposes shall be the sale or contract unit price times the number of units sold, Provided, however, That where the authorized officer determines: (1) That a contract of sale... whole or in part upon considerations other than the value of the commodities, or (2) That no bona fide...

30 CFR 1206.301 - Value basis for royalty computation.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) The gross value for royalty purposes shall be the sale or contract unit price times the number of units sold, Provided, however, That where the authorized officer determines: (1) That a contract of sale... whole or in part upon considerations other than the value of the commodities, or (2) That no bona fide...

30 CFR 206.301 - Value basis for royalty computation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... gross value for royalty purposes shall be the sale or contract unit price times the number of units sold, Provided, however, That where the authorized officer determines: (1) That a contract of sale or other... lease is not a bona fide transaction between independent parties because it is based in whole or in part...

Measuring contraction propagation and localizing pacemaker cells using high speed video microscopy

PubMed Central

Akl, Tony J.; Nepiyushchikh, Zhanna V.; Gashev, Anatoliy A.; Zawieja, David C.; Coté, Gerard L.

2011-01-01

Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location of the pacemaker sites within these vessels has proven to be very difficult. A high speed video microscopy system with an automated algorithm to detect pacemaker location and calculate the propagation velocity, speed, duration, and frequency of the contractions is presented in this paper. Previous methods for determining the contractile wave propagation velocity manually were time consuming and subject to errors and potential bias. The presented algorithm is semiautomated giving objective results based on predefined criteria with the option of user intervention. The system was first tested on simulation images and then on images acquired from isolated microlymphatic mesenteric vessels. We recorded contraction propagation velocities around 10 mm∕s with a shortening speed of 20.4 to 27.1 μm∕s on average and a contraction frequency of 7.4 to 21.6 contractions∕min. The simulation results showed that the algorithm has no systematic error when compared to manual tracking. The system was used to determine the pacemaker location with a precision of 28 μm when using a frame rate of 300 frames per second. PMID:21361700

[Remunerations, benefits and labor incentives perceived by health care workers in Peru: an analysis comparing the Ministry of Health and the Social Insurance, 2009].

PubMed

Pardo, Karim; Andia, Marcelino; Rodriguez, Amado; Pérez, Walter; Moscoso, Betsy

2011-06-01

To describe the main characteristics of the general salaries situation and the incentive policies of health care workers of Peru, comparing them by their origin institution and type of contract. A mixed design study was done including both quantitative and qualitative components during 2008 and 2009 with both professional and technical personnel of the Ministry of Health (MINSA) and the Social Insurance (EsSalud) in Peru. The salary structure was primarily evaluated considering incentives, bonuses and other remunerations according to position, type of contract and work place. Remuneration and bonus policies at the national level are determined by the responsibilities and amount of time served. The type of contract is determined by the programs of the public system (DL 276) and the private system (DL 728), also by the Special Program of Contract Services Administration (CAS) and exclusively in MINSA contracting is determined by local health administration Committees (CLAS). The salary structure differs between both types of institutions, especially with respect to incentives and benefits. An special economic incentive for assistance (AETA) is unique to MINSA, but the proportion of assistance varies by region. The professionals of MINSA have lower salaries than those of EsSalud, in all types of contracts. A professional contracted through CAS generally has a lower salary than staff peers in MINSA, though this situation is reversed in EsSalud. The lowest salaries are found in contracts made through CLAS. The structure and salary amounts differ between MINSA and EsSalud, just as they differ by existing contracting types.

Contracts: Making the Transition from Residency to Work, Work for You

PubMed Central

Snelson, Elizabeth A.; Moore, Christopher E.

2011-01-01

Residents completing colon and rectal surgery training should take seriously the terms of contracts offered to them. Contracts should specify how and how much salary will be paid, what benefits the surgeon will receive, and what services are to be provided. However, contracts frequently fail to disclose what costs the surgeon will have to cover that will lower that salary, what hours the surgeon must keep, and what time off the surgeon may expect. Signing a contract is easily done, but getting out of a contract to take a better job or move to another community may be difficult because of the wording in the contact. Surgeons need to have professional help to determine whether to sign a contract and what that contract should provide. An attorney experienced in representing physicians can be recommended by the physician's medical association. PMID:22654571

Real option valuation of a decremental regulation service provided by electricity storage.

PubMed

Szabó, Dávid Zoltán; Martyr, Randall

2017-08-13

This paper is a quantitative study of a reserve contract for real-time balancing of a power system. Under this contract, the owner of a storage device, such as a battery, helps smooth fluctuations in electricity demand and supply by using the device to increase electricity consumption. The battery owner must be able to provide immediate physical cover, and should therefore have sufficient storage available in the battery before entering the contract. Accordingly, the following problem can be formulated for the battery owner: determine the optimal time to enter the contract and, if necessary, the optimal time to discharge electricity before entering the contract. This problem is formulated as one of optimal stopping, and is solved explicitly in terms of the model parameters and instantaneous values of the power system imbalance. The optimal operational strategies thus obtained ensure that the battery owner has positive expected economic profit from the contract. Furthermore, they provide explicit conditions under which the optimal discharge time is consistent with the overall objective of power system balancing. This paper also carries out a preliminary investigation of the 'lifetime value' aggregated from an infinite sequence of these balancing reserve contracts. This lifetime value, which can be viewed as a single project valuation of the battery, is shown to be positive and bounded. Therefore, in the long run such reserve contracts can be beneficial to commercial operators of electricity storage, while reducing some of the financial and operational risks in power system balancing.This article is part of the themed issue 'Energy management: flexibility, risk and optimization'. © 2017 The Author(s).

Analysis of consultants' NHS and private incomes in England in 2003/4

PubMed Central

Morris, Stephen; Elliott, Bob; Ma, Ada; McConnachie, Alex; Rice, Nigel; Skåtun, Diane; Sutton, Matt

2008-01-01

Summary Objective Consultants employed by the NHS in England are allowed to undertake private practice to supplement their NHS income. Until the introduction of a new contract from October 2003, those employed on full-time contracts were allowed to earn private incomes no greater than 10% of their NHS income. In this paper we investigate the magnitude and determinants of consultants' NHS and private incomes. Design Quantitative analysis of financial data. Setting A unique, anonymized, non-disclosive dataset derived from tax returns for a sample of 24,407 consultants (92.3% of the total) in England for the financial year 2003/4. Main outcome methods The conditional mean total, NHS and private incomes earned by age group, type of contract, specialty and region of place of work. Results The mean annual total, NHS and private incomes across all consultants in 2003/4 were £110,773, £76,628 and £34,144, respectively. Incomes varied by age, type of contract, specialty and region of place of work. The ratio of mean private to NHS income for consultants employed on a full-time contract was 0.26. The mean private income across specialties ranged from £5,144 (for paediatric neurology) to £142,723 (plastic surgery). There was a positive association between mean private income and NHS waiting lists across specialties. Conclusions Consultants employed on full-time contracts on average exceeded the limits on private income stipulated by the 10% rule. Specialty is a more important determinant of income than the region in which the consultant works. Further work is required to explore the association between mean private income and waiting lists. PMID:18591691

[Decreased retraction of blood clots in patients with venous thromboembolic complications].

PubMed

Bredikhin, R A; Peshkova, A D; Maliasev, D V; Batrakova, M V; Le Min, J; Panasiuk, M V; Fatkhullina, L S; Ignat'ev, I M; Khaĭrullin, R N; Litvinov, R I

Haemostatic disorders play an important role in the pathogenesis of acute venous thrombosis. One of the least studied reactions of blood coagulation and thrombogenesis is spontaneous contraction of blood clots, which takes place at the expense of the contractility apparatus of activated blood platelets adhered to fibrin fibres. The work was aimed at studying the parameters of contraction of blood clots, formed in vitro, in blood of 41 patients with acute venous thromboses as compared with the same parameters in apparently healthy donors. We used a new instrumental method making it possible to determine the time from initiation to the beginning of contraction, as well as the degree and velocity of clot contraction. It was revealed that in patients with venous thrombosis the ability of clots to shrink was significantly reduced as compared with the control. We detected a statistically significant retardation of and decrease in of blood clot concentration in patients with venous thrombosis complicated by pulmonary artery thromboembolism as compared with contraction in patients with isolated deep vein thrombosis, witch may be important for early diagnosis and determination of the risk of thromboembolism. Besides, we revealed a statistically significant retardation of contraction in patients with proximal thrombosis as compared with contraction in patients with distal thrombosis, with similar values of the degree of contraction. Contraction was statistically significantly reduced in acute thrombosis (less than 21 days), whereas in subacute thrombosis (more than 21 days) the parameters of contraction were closer to normal values. The obtained findings suggest that reduction of blood clot contraction may be a new, hitherto unstudied pathogenetic mechanism deteriorating the course and outcome of venous thrombosis. The clinical significance of contraction and its impairments, as well as the diagnostic and prognostic value of the laboratory test for blood clot contraction would merit further study.

Acoustic myography as an indicator of force during sustained contractions of a small hand muscle.

PubMed

Goldenberg, M S; Yack, H J; Cerny, F J; Burton, H W

1991-01-01

To test the hypothesis that muscle sound amplitudes would remain constant during sustained submaximal isometric contractions, we recorded acoustic myograms from the abductor digiti minimi muscle in 12 subjects at 15, 25, 50, and 75% of a maximum voluntary contraction (MVC). Muscle sounds were detected with an omni-directional electret microphone encased in closed-cell foam and attached to the skin over the muscle. Acoustic amplitudes from the middle and end of the sustained contractions were compared with the amplitudes from the beginning of contractions to determine whether acoustic amplitudes varied in magnitude as force remained constant. Physiological tremor was eliminated from the acoustic signal by use of a Fourier truncation at 14 Hz. The amplitudes of the acoustic signal at a contraction intensity of 75% MVC remained constant, reflecting force production over time. At 50% MVC, the root-mean-square amplitude decreased from the beginning to the end of the contraction (P less than 0.05). Acoustic amplitudes increased over time at 15 and 25% MVC and were significantly higher at the end of the contractions than at the beginning (P less than 0.05). Alterations in the acoustic amplitude, which reflect changes in the lateral vibrations of the muscle, may be indicative of the different recruitment strategies used to maintain force during sustained isometric contractions.

Development of an improved system for contract time determination : phase III.

DOT National Transportation Integrated Search

2010-09-30

This study developed Daily Work Report (DWR) based prediction models to determine reasonable : production rates of controlling activities of highway projects. The study used available resources such as : DWR, soil data, AADT and other existing projec...

42 CFR 423.643 - Effect of contract determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of contract determination. 423.643 Section 423.643 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Determinations and Appeals § 423.643 Effect of contract determination. The contract determination is final and...

Contraction coupling efficiency of human first dorsal interosseous muscle.

PubMed

Jubrias, Sharon A; Vollestad, Nina K; Gronka, Rod K; Kushmerick, Martin J

2008-04-01

During working contractions, chemical energy in the form of ATP is converted to external work. The efficiency of this conversion, called 'contraction coupling efficiency', is calculated by the ratio of work output to energy input from ATP splitting. Experiments on isolated muscles and permeabilized fibres show the efficiency of this conversion has a wide range, 0.2-0.7. We measured the work output in contractions of a single human hand muscle in vivo and of the ATP cost of that work to calculate the contraction coupling efficiency of the muscle. Five subjects performed six bouts of rapid voluntary contractions every 1.5 s for 42 s (28 contractions, each with time to peak force < 150 ms). The bouts encompassed a 7-fold range of workloads. The ATP cost during work was quantified by measuring the extent of chemical changes within the muscle from (31)P magnetic resonance spectra. Contraction coupling efficiency was determined as the slope of paired measurements of work output and ATP cost at the five graded work loads. The results show that 0.68 of the chemical energy available from ATP splitting was converted to external work output. A plausible mechanism to account for this high value is a substantially lower efficiency for mitochondrial ATP synthesis. The method described here can be used to analyse changes in the overall efficiency determined from oxygen consumption during exercise that can occur in disease or with age, and to test the hypothesis that such changes are due to reduced contraction coupling efficiency.

24 CFR 203.281 - Calculation of one-time MIP.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-One-Time Payment § 203.281 Calculation of one-time MIP. (a) The applicable premium percentage determined...

24 CFR 203.281 - Calculation of one-time MIP.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-One-Time Payment § 203.281 Calculation of one-time MIP. (a) The applicable premium percentage determined...

Contract Source Selection: An Analysis of Lowest Price Technically Acceptable and Tradeoff Strategies

DTIC Science & Technology

2016-06-15

selection strategy is key to minimizing risk and ensuring best value for all stakeholders. On the basis of thorough market research , acquisition...administrative lead-time, Contractor Performance Assessment Reporting System ratings, and earned value management assessments) and source selection strategy ...Postgraduate School A. PURPOSE This research analyzes LPTA and tradeoff source selection strategies and contract outcomes to determine if a relationship

Immigration, work and health in Spain: the influence of legal status and employment contract on reported health indicators

PubMed Central

Agudelo-Suárez, Andrés; Benavides, Fernando G.; Schenker, Marc; García, Ana M.; Benach, Joan; Delclos, Carlos; López-Jacob, María José; Ruiz-Frutos, Carlos; Ronda-Pérez, Elena; Porthé, Victoria

2010-01-01

Objective To analyze the relationship of legal status and employment conditions with health indicators in foreign-born and Spanish-born workers in Spain. Methods Cross-sectional study of 1,849 foreign-born and 509 Spanish-born workers (2008–2009, ITSAL Project). Considered employment conditions: permanent, temporary and no contract (foreign-born and Spanish-born); considered legal statuses: documented and undocumented (foreign-born). Joint relationships with self-rated health (SRH) and mental health (MH) were analyzed via logistical regression. Results When compared with male permanently contracted Spanish-born workers, worse health is seen in undocumented foreign-born, time in Spain ≤3 years (SRH aOR 2.68, 95% CI 1.09–6.56; MH aOR 2.26, 95% CI 1.15–4.42); in Spanish-born, temporary contracts (SRH aOR 2.40, 95% CI 1.04–5.53); and in foreign-born, temporary contracts, time in Spain >3 years (MH: aOR 1.96, 95% CI 1.13–3.38). In females, highest self-rated health risks are in foreign-born, temporary contracts (aOR 2.36, 95% CI 1.13–4.91) and without contracts, time in Spain >3 years (aOR 4.63, 95% CI 1.95–10.97). Conclusions Contract type is a health determinant in both foreign-born and Spanish-born workers. This study offers an uncommon exploration of undocumented migration and raises methodological issues to consider in future research. PMID:20401513

Muscle strength at the trunk*.

PubMed

Smidt, G L; Amundsen, L R; Dostal, W F

1980-01-01

The purpose of this study was to determine the strength of trunk flexors and extensors in normal male subjects during isometric, concentric, and eccentric contractions. Subjects were tested in the sidelying position to minimize the effects of gravity. The pelvis and lower extremities were measured on a custom built force table (lowa Force Table). Muscle strength was expressed as a moment of force (external force times the moment arm) in Newton-meter (Nm) units. Greater Nm were registered in the muscle-lengthened position than in the muscle-shortened position for all isometric contractions. The Nm registered for eccentric contractions always exceeded the Nm registered for concentric contractions of the same muscle group. The Nm registered during contractions of trunk extensors always exceeded the values obtained during corresponding modes of contractions (isometric, eccentric, and concentric) of trunk flexors.J Orthop Sports Phys Ther 1980;1(3):165-170.

42 CFR 422.646 - Effect of contract determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Effect of contract determination. 422.646 Section 422.646 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Appeals § 422.646 Effect of contract determination. The contract determination is final and binding unless...

48 CFR 218.270 - Head of contracting activity determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 218.270 Head of contracting activity determinations. For contract... contracting activity,” as defined in FAR 2.101, in the following locations: (a) FAR 2.101: (1) Definition of...

Effect of intermittent eccentric contractions on symptoms of muscle microinjury.

PubMed

Teague, B N; Schwane, J A

1995-10-01

The purpose was to determine whether varying the duration of rest between contractions affects selected symptoms of eccentric contraction-induced skeletal muscle microinjury. Thirty-three women were assigned to three groups (N = 11). Each performed one bout of exercise with each arm involving 10 eccentric contractions of the elbow flexor muscles, lowering a load equaling 60% of maximal static force. One arm exercised continuously; the other exercised with rest periods of 15 s, 5 min, or 10 min between contractions, depending on the group. Preexercise and 0, 24, and 48 h postexercise, symptoms of microinjury in the elbow flexor muscles were assessed: soreness and changes in strength, resting elbow angle ("musculotendinous stiffness"), and arm girth ("swelling"). For all groups combined, 10 continuous contractions caused changes (P < 0.05) in all variables at every measurement time. For example, soreness ratings (0-10 scale) were 4.3 +/- 2.0 (24 h) and 4.3 +/- 2.1 (48 h) and strength was reduced 18% 0 h postexercise. Responses were similar with 15 s of rest between contractions. Although they were moderated, symptoms occurred even with 5 and 10 min of rest. With 10 min between contractions, soreness occurred (e.g., 2.4 +/- 1.5 [24 h]) and strength was 17% reduced 0 h postexercise. Results are most consistent with a mechanical cause of eccentric contraction-induced muscle microinjury, rather than a metabolic or other factor with a short recovery time, although involvement of the latter cannot be ruled out.

Broadband Laser Ranging for Position Measurements in Shock Physics Experiments

NASA Astrophysics Data System (ADS)

Rhodes, Michelle; Bennett, Corey; Daykin, Edward; Younk, Patrick; Lalone, Brandon; Kostinski, Natalie

2017-06-01

Broadband laser ranging (BLR) is a recently developed measurement system that provides an attractive option for determining the position of shock-driven surfaces. This system uses broadband, picosecond (or femtosecond) laser pulses and a fiber interferometer to measure relative travel time to a target and to a reference mirror. The difference in travel time produces a delay difference between pulse replicas that creates a spectral beat frequency. The spectral beating is recorded in real time using a dispersive Fourier transform and an oscilloscope. BLR systems have been designed that measure position at 12.5-40 MHz with better than 100 micron accuracy over ranges greater than 10 cm. We will give an overview of the basic operating principles of these systems. Prepared by LLNL under Contract DE-AC52-07NA27344, by LANL under Contract DE-AC52-06NA25396, and by NSTec Contract DE-AC52-06NA25946.

Relationship between mechanical dyssynchrony and intra-operative electrical delay times in patients undergoing cardiac resynchronization therapy

PubMed Central

2014-01-01

Background It is important to understand the relationship between electrical and mechanical ventricular activation in CRT patients. By measuring local electrical activation at multiple locations within the coronary veins and myocardial contraction at the same locations in the left ventricle, we determined the relationship between electrical and mechanical activation at potential left ventricular pacing locations. Methods In this study, mechanical contraction times were computed using high temporal resolution cine cardiovascular magnetic resonance (CMR) data, while electrical activation times were derived from intra-procedural local electrograms. Results In our cohort, there was a strong correlation between electrical and mechanical delay times within each patient (R2 = 0.78 ± 0.23). Additionally, the latest electrically activated location corresponded with the latest mechanically contracting location in 91% of patients. Conclusions This study provides initial evidence that our method of obtaining non-invasive mechanical activation patterns accurately reflects the underlying electromechanical substrate of intraventricular dyssynchrony. PMID:24393383

AMPKα2 deficiency uncovers time dependency in the regulation of contraction-induced palmitate and glucose uptake in mouse muscle.

PubMed

Abbott, Marcia J; Bogachus, Lindsey D; Turcotte, Lorraine P

2011-07-01

AMP-activated protein kinase (AMPK) is a fuel sensor in skeletal muscle with multiple downstream signaling targets that may be triggered by increases in intracellular Ca(2+) concentration ([Ca(2+)]). The purpose of this study was to determine whether increases in intracellular [Ca(2+)] induced by caffeine act solely via AMPKα(2) and whether AMPKα(2) is essential to increase glucose uptake, fatty acid (FA) uptake, and FA oxidation in contracting skeletal muscle. Hindlimbs from wild-type (WT) or AMPKα(2) dominant-negative (DN) transgene mice were perfused during rest (n = 11), treatment with 3 mM caffeine (n = 10), or muscle contraction (n = 11). Time-dependent effects on glucose and FA uptake were uncovered throughout the 20-min muscle contraction perfusion period (P < 0.05). Glucose uptake rates did not increase in DN mice during muscle contraction until the last 5 min of the protocol (P < 0.05). FA uptake rates were elevated at the onset of muscle contraction and diminished by the end of the protocol in DN mice (P < 0.05). FA oxidation rates were abolished in the DN mice during muscle contraction (P < 0.05). The DN transgene had no effect on caffeine-induced FA uptake and oxidation (P > 0.05). Glucose uptake rates were blunted in caffeine-treated DN mice (P < 0.05). The DN transgene resulted in a greater use of intramuscular triglycerides as a fuel source during muscle contraction. The DN transgene did not alter caffeine- or contraction-mediated changes in the phosphorylation of Ca(2+)/calmodulin-dependent protein kinase I or ERK1/2 (P > 0.05). These data suggest that AMPKα(2) is involved in the regulation of substrate uptake in a time-dependent manner in contracting muscle but is not necessary for regulation of FA uptake and oxidation during caffeine treatment.

Muscle spindle response at the onset of isometric voluntary contractions in man. Time difference between fusimotor and skeletomotor effects

PubMed Central

Vallbo, Å. B.

1971-01-01

1. Impulses in single muscle afferents were recorded from the median nerves of waking human subjects with percutaneously inserted tungsten needle electrodes. During isometric voluntary contractions, unitary discharges were analysed from muscle spindle endings in the wrist and finger flexor muscles and the electromyographic activity from these muscles was recorded simultaneously. 2. When the subject activated the muscle portion in which a spindle was located, the afferent discharge increased in spite of the mechanical unloading effects of the skeletomotor contraction indicating a concomitant fusimotor activation. This was valid for slowly rising contractions as well as small fast rising twitches. 3. The time of onset of spindle acceleration was determined in relation to the time of onset of the electromyographic activity for thirty-one units studied altogether in more than seven hundred contractions. It was found that spindle acceleration regularly occurred after the onset of the electromyographic activity. 4. There was a considerable variation from one test to the other, for the individual units, with regard to the exact time of onset of spindle acceleration, although spindle acceleration occurred mostly within 0·5 sec after the onset of the electromyographic activity in sustained contractions and within 0·1 sec in small fast rising twitches. It was not possible to assess to what extent this variation was accounted for by variations in the mechanical unloading effects of the skeletomotor contraction or variations in the timing of the fusimotor outflow. 5. For many units, spindle acceleration did not occur until 10-50 msec after the onset of the skeletomotor contraction. This time is of the same order of magnitude as the time difference in latency from the spinal cord to the recording points in the two systems, as estimated from reasonable assumptions. 6. It was concluded that the fusimotor system does not participate in the initiation of voluntary contractions in man, but that the skeletomotor activity is initiated by descending impulses from supraspinal structures and their effects on the neuronal organization within the spinal cord. 7. The fact that fusimotor activation occurs also in very small and short lasting twitches, when spindle acceleration must have a negligible influence on the skeletomotor outflow, suggests that the fusimotor and the skeletomotor systems are rigidly co-activated in voluntary contractions. 8. The finding that spindle acceleration does not occur until 10-50 msec after the onset of the electromyographic activity suggests that there is an approximately simultaneous onset of the fusimotor and the skeletomotor outflows from the spinal cord. PMID:4256547

25 CFR 900.134 - At the end of a self-determination construction contract, what happens to savings on a cost...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false At the end of a self-determination construction contract... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.134 At the end of a self-determination construction contract, what happens to savings on a cost...

25 CFR 900.134 - At the end of a self-determination construction contract, what happens to savings on a cost...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false At the end of a self-determination construction contract... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.134 At the end of a self-determination construction contract, what happens to savings on a cost...

25 CFR 900.134 - At the end of a self-determination construction contract, what happens to savings on a cost...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 2 2011-04-01 2011-04-01 false At the end of a self-determination construction contract... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.134 At the end of a self-determination construction contract, what happens to savings on a cost...

25 CFR 900.134 - At the end of a self-determination construction contract, what happens to savings on a cost...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false At the end of a self-determination construction contract... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.134 At the end of a self-determination construction contract, what happens to savings on a cost...

25 CFR 900.134 - At the end of a self-determination construction contract, what happens to savings on a cost...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 2 2012-04-01 2012-04-01 false At the end of a self-determination construction contract... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.134 At the end of a self-determination construction contract, what happens to savings on a cost...

48 CFR 2915.405-70 - Determining fair and reasonable price.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Determining fair and reasonable price. 2915.405-70 Section 2915.405-70 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 2915.405-70 Determining...

48 CFR 335.071 - Special determinations and findings affecting research and development contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... findings affecting research and development contracting. 335.071 Section 335.071 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 Special determinations and findings affecting research and development contracting. OPDIV...

48 CFR 32.203 - Determining contract financing terms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... financing terms. 32.203 Section 32.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Commercial Item Purchase Financing 32.203 Determining contract financing terms. When the criteria in 32.202-1(b) are met, the contracting officer may either...

24 CFR 203.283 - Refund of one-time MIP.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-One-Time... the mortgage was endorsed for insurance. The Commissioner shall determine the applicable premium... generated by insurance claims, and (3) expected future payments of premium refunds. [48 FR 28806, June 23...

24 CFR 203.283 - Refund of one-time MIP.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-One-Time... the mortgage was endorsed for insurance. The Commissioner shall determine the applicable premium... generated by insurance claims, and (3) expected future payments of premium refunds. [48 FR 28806, June 23...

13 CFR 121.1009 - What are the procedures for making the size determination?

Code of Federal Regulations, 2010 CFR

2010-01-01

... determination? (a) Time frame for making size determination. After receipt of a protest or a request for a... effective immediately and remains in full force and effect unless and until reversed by OHA. (2) A... that procurement or sale, but will have future effect, unless the contracting officer agrees to apply...

Influence of Time Management Concepts on the Productivity of Vocational Teachers. Final Report. Time Management Concept Project. Department Report No. 57.

ERIC Educational Resources Information Center

Nebraska Univ., Lincoln. Dept. of Agricultural Education.

A study was conducted to determine how vocational teachers used their time, whether teachers in different vocational areas used their time differently, whether a workshop on time management would improve their use of time, and if such factors as marital status, sex, and extended contracts influenced how vocational teachers used their time. Random…

24 CFR 888.420 - One-time Contract Rent determination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROGRAM, SECTION 202 SUPPORTIVE HOUSING FOR THE ELDERLY PROGRAM AND SECTION 811 SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM-FAIR MARKET RENTS AND...

48 CFR 35.006 - Contracting methods and contract type.

Code of Federal Regulations, 2011 CFR

2011-10-01

... indicated a high degree of probability that development is feasible and (2) the Government has determined... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and..., performance objectives, and specifications for the work can be defined will largely determine the type of...

48 CFR 942.705-1 - Contracting officer determination procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting officer determination procedure. 942.705-1 Section 942.705-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 942.705-1 Contracting...

Optimal Reservoir Operation using Stochastic Model Predictive Control

NASA Astrophysics Data System (ADS)

Sahu, R.; McLaughlin, D.

2016-12-01

Hydropower operations are typically designed to fulfill contracts negotiated with consumers who need reliable energy supplies, despite uncertainties in reservoir inflows. In addition to providing reliable power the reservoir operator needs to take into account environmental factors such as downstream flooding or compliance with minimum flow requirements. From a dynamical systems perspective, the reservoir operating strategy must cope with conflicting objectives in the presence of random disturbances. In order to achieve optimal performance, the reservoir system needs to continually adapt to disturbances in real time. Model Predictive Control (MPC) is a real-time control technique that adapts by deriving the reservoir release at each decision time from the current state of the system. Here an ensemble-based version of MPC (SMPC) is applied to a generic reservoir to determine both the optimal power contract, considering future inflow uncertainty, and a real-time operating strategy that attempts to satisfy the contract. Contract selection and real-time operation are coupled in an optimization framework that also defines a Pareto trade off between the revenue generated from energy production and the environmental damage resulting from uncontrolled reservoir spills. Further insight is provided by a sensitivity analysis of key parameters specified in the SMPC technique. The results demonstrate that SMPC is suitable for multi-objective planning and associated real-time operation of a wide range of hydropower reservoir systems.

41 CFR 101-39.102-2 - Effective date of determination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.102-2 Effective date of determination. Unless a longer time is... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Effective date of...

The shape of uterine contractions and labor progress in the spontaneous active labor.

PubMed

Ebrahimzadeh Zagami, Samira; Golmakani, Nahid; Saadatjoo, Seyyed Ali-Reza; Ghomian, Nayyereh; Baghbani, Behjat

2015-03-01

Dystocia is the most common indication of primary cesarean section. The most common cause of dystocia is uterine dysfunction. In prolonged labor, more attention is usually paid to the fetus and pelvis rather than to the role of uterine contractions in a delivery. Therefore, we decided to determine the relationship between the labor progress and uterine contractions shapes. In this cross-sectional study, 200 primiparous women participated having a single pregnancy and cephalic presentation. Uterus contractions were recorded using electronic fetal monitoring at the beginning of the active phase of labor (dilatation 3-5 cm) for 30 min. Fall to rise (F:R) ratio was calculated by determining the duration of returning from a contraction peak to its baseline (fall) and the duration of the rise time from baseline to peak (rise) in two groups. The data were analyzed using t-test and Chi-square test. In this study, 162 women had a normal delivery and 38 women had a cesarean (CS) delivery due to the lack of labor progress. The average F:R ratio was 1.13±0.193 seconds in the vaginal delivery group and 1.64±0.301 seconds in the CS group. This difference was statistically significant (P<0.001). The frequency of contractions in the vaginal delivery group was more than the CS group (P=0.008). Our findings demonstrated that uterine contractions shapes change; and F:R ratio was higher in the group that lacked labor progress. Therefore, contraction shapes can be used to predict the labor progress.

Risk factors for injury among construction workers at Denver International Airport.

PubMed

Lowery, J T; Borgerding, J A; Zhen, B; Glazner, J E; Bondy, J; Kreiss, K

1998-08-01

The Denver International Airport construction project provided a rare opportunity to identify risk factors for injury on a large construction project for which 769 contractors were hired to complete 2,843 construction contracts. Workers' compensation claims and payroll data for individual contracts were recorded in an administrative database developed by the project's Owner-Controlled Insurance Program. From claims andy payroll data linked with employee demographic information, we calculated injury rates per 200,000 person-hours by contract and over contract characteristics of interest. We used Poisson regression models to examine contract-specific risk factors in relation to total injuries, lost-work-time (LWT), and non-LWT injuries. We included contract-specific expected loss rates (ELRs) in the model to control for prevailing risk of work and used logistic regression methods to determine the association between LWT and non-LWT injuries on contracts. Injury rates were highest during the first year of construction, at the beginning of contracts, and among older workers. Risk for total and non-LWT injuries was elevated for building construction contracts, contract for special trades companies (SIC 17), contracts with payrolls over $1 million, and those with overtime payrolls greater than 20%. Risk for LWT injuries only was increased for site development contracts and contract starting in the first year of construction. Contracts experiencing one or more minor injuries were four times as likely to have at least one major injury (OR = 4.0, 95% CI (2.9, 5.5)). Enhancement of DIA's safety infrastructure during the second year of construction appears to have been effective in reducing serious (LWT) injures. The absence of correlation between injury rates among contracts belonging to the same company suggest that targeting of safety resources at the level of the contract may be an effective approach to injury prevention. Interventions focused on high-risk contracts, including those with considerable overtime work, contracts held by special trades contractors (SIC 17), and contracts belonging to small and mid-sized companies, and on high-risk workers, such as those new to a construction site or new to a contract may reduce injury burden on large construction sites. The join occurrence of minor and major injuries on a contract level suggests that surveillance of minor injuries may be useful in identifying opportunities for prevention of major injures.

Oxygen exchange profile in rat muscles of contrasting fibre types.

PubMed

Behnke, Brad J; McDonough, Paul; Padilla, Danielle J; Musch, Timothy I; Poole, David C

2003-06-01

To determine whether fibre type affects the O2 exchange characteristics of skeletal muscle at the microcirculatory level we tested the hypothesis that, following the onset of contractions, muscle comprising predominately type I fibres (soleus, Sol, 86 % type I) would, based on demonstrated blood flow responses, exhibit a blunted microvascular PO2 (PO2,m, which is determined by the O2 delivery (QO2) to O2 uptake (VO2) ratio) profile (assessed via phosphorescence quenching) compared to muscle of primarily type II fibres (peroneal, Per, 84 % type II). PO2,m was measured at rest, and following the rest-contractions (twitch, 1 Hz, 2-4 V for 120 s) transition in Sol (n = 6) and Per (n = 6) muscles of Sprague-Dawley rats. Both muscles exhibited a delay followed by a mono-exponential decrease in PO2,m to the steady state. However, compared with Sol, Per demonstrated (1) a larger change in baseline minus steady state contracting PO2,m (DeltaPO2,m) (Per, 13.4 +/- 1.7 mmHg; Sol, 8.6 +/- 0.9 mmHg, P < 0.05); (2) a faster mean response time (i.e. time delay (TD) plus time constant (tau); Per, 23.8 +/- 1.5 s; Sol, 39.6 +/- 4.3 s, P < 0.05); and therefore (3) a greater rate of PO2,m decline (DeltaPO2,m/tau; Per, 0.92 +/- 0.08 mmHg s-1; Sol, 0.42 +/- 0.05 mmHg s-1, P < 0.05). These data demonstrate an increased microvascular pressure head of O2 at any given point after the initial time delay for Sol versus Per following the onset of contractions that is probably due to faster QO2 dynamics relative to those of VO2.

The effects of neuromuscular electrical stimulation at different frequencies on the activations of deep abdominal stabilizing muscles.

PubMed

Cho, Hee Kyung; Jung, Gil Su; Kim, Eun Hyuk; Cho, Yun Woo; Kim, Sang Woo; Ahn, Sang Ho

2016-01-01

Low back pain is associated with transversus abdominis (TrA) dysfunction. Recently, it was proposed that Neuromuscular Electrical Stimulation (NMES) could be used to stimulate deep abdominal muscle contractions and improve lumbopelvic stability. The purpose of this study was to determine the optimal stimulation frequency required during NMES for the activation of deep abdominal muscles. Twenty healthy volunteers between the ages of 24 and 32 were included. The portable research-stimulator was applied using a 10 second contraction time, and a 10 second resting time at 20 Hz, 50 Hz, and 80 Hz. Changes in muscle thicknesses were determined for the TrA, obliquus internus (OI), and obliquus externus (OE) by real time ultrasound imaging. Significant thickness increases in the TrA, OI, and OE were observed during NMES versus the resting state (p < 0.05). Of the frequencies examined, 50 Hz NMES produced the greatest increase in TrA thickness (1.33 fold as compared with 1.22 fold at 20 Hz and 1.21 fold at 80 Hz) (p < 0.05). Our results indicate that NMES can preferentially stimulate contractions in deep abdominal stabilizing muscles. Most importantly, 50 Hz NMES produced greater muscle thickness increases than 20 or 80 Hz.

Assessing the pro-poor effect of different contracting schemes for health services on health facilities in rural Afghanistan.

PubMed

Alonge, Olakunle; Gupta, Shivam; Engineer, Cyrus; Salehi, Ahmad Shah; Peters, David H

2015-12-01

Despite progress in improving health outcomes in Afghanistan by contracting public health services through non-governmental organizations (NGOs), inequity in access persists between the poor and non-poor. This study examined the distributive effect of different contracting types on primary health services provision between the poor and non-poor in rural Afghanistan. Contracts to NGOs were made to deliver a common set of primary care services in each province, with the funding agencies determining contract terms. The contracting approaches could be classified into three contracting out types (CO-1, CO-2 and CO-3) and a contracting-in (CI) approach based on the contract terms, design and implementation. Exit interviews of patients attending randomly sampled primary health facilities were collected through systematic sampling across 28 provinces at two time points. The outcome, the odds that a client attending a health facility is poor, was modelled using logistic regression with a robust variance estimator, and the effect of contracting was estimated using the difference-in-difference approach combined with stratified analyses. The sample covered 5960 interviews from 306 health facilities in 2005 and 2008. The adjusted odds of a poor client attending a health facility over time increased significantly for facilities under CO-1 and CO-2, with odds ratio of 2.82 (1.49, 5.36) P-value 0.001 and 2.00 (1.33, 3.02) P-value 0.001, respectively. The odds ratios for those under CO-3 and CI were not statistically significantly different over time. When compared with the non-contracting facilities, the adjusted ratio of odds ratios of poor status among clients was significantly higher for only those under CO-1, ratio of 2.50 (1.32, 4.74) P-value 0.005. CO-1 arrangement which allows contractors to decide on how funds are allocated within a fixed lump sum with non-negotiable deliverables, and actively managed through an independent government agency, is effective in improving equity of health services provision. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2014; all rights reserved.

48 CFR 6301.5 - Contract appeals procedures (general).

Code of Federal Regulations, 2010 CFR

2010-10-01

...). (a) It is the intent of these rules to provide for the just and inexpensive determination of appeals... disclosure of relevant and material facts, and to discourage surprise. Each specified time limitation is a... Board may extend any time limitation for good cause and in accordance with legal precedent. (b...

48 CFR 6301.5 - Contract appeals procedures (general).

Code of Federal Regulations, 2011 CFR

2011-10-01

... Board may extend any time limitation for good cause and in accordance with legal precedent. (b...). (a) It is the intent of these rules to provide for the just and inexpensive determination of appeals... disclosure of relevant and material facts, and to discourage surprise. Each specified time limitation is a...

The use of real-time ultrasound imaging for biofeedback of lumbar multifidus muscle contraction in healthy subjects.

PubMed

Van, Khai; Hides, Julie A; Richardson, Carolyn A

2006-12-01

Randomized controlled trial. To determine if the provision of visual biofeedback using real-time ultrasound imaging enhances the ability to activate the multifidus muscle. Increasingly clinicians are using real-time ultrasound as a form of biofeedback when re-educating muscle activation. The effectiveness of this form of biofeedback for the multifidus muscle has not been reported. Healthy subjects were randomly divided into groups that received different forms of biofeedback. All subjects received clinical instruction on how to activate the multifidus muscle isometrically prior to testing and verbal feedback regarding the amount of multifidus contraction, which occurred during 10 repetitions (acquisition phase). In addition, 1 group received visual biofeedback (watched the multifidus muscle contract) using real-time ultrasound imaging. All subjects were reassessed a week later (retention phase). Subjects from both groups improved their voluntary contraction of the multifidus muscle in the acquisition phase (P<.001) and the ability to recruit the multifidus muscle differed between groups (P<.05), with subjects in the group that received visual ultrasound biofeedback achieving greater improvements. In addition, the group that received visual ultrasound biofeedback retained their improvement in performance from week 1 to week 2 (P>.90), whereas the performance of the other group decreased (P<.05). Real-time ultrasound imaging can be used to provide visual biofeedback and improve performance and retention in the ability to activate the multifidus muscle in healthy subjects.

48 CFR 22.1008-1 - Obtaining wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... determinations using the WDOL website. Contracting officers may also use the Department of Labor's e98 electronic... Labor. If the WDOL database does not contain the applicable prevailing wage determination for a contract action, the contracting officer must use the e98 process to request a wage determination from the...

48 CFR 22.1012-1 - Prevailing wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Prevailing wage... wage determination in a solicitation, contract or contract modification (see 22.1007) is determined by... wage determination shall not be effective if it is received by the contracting agency less than 10 days...

41 CFR 50-203.22 - Effective date of determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations Under the Walsh-Healey Public Contracts Act § 50-203.22 Effective date of determinations. Any minimum wage determination issued as a result of hearings held under this subpart shall take effect not less...

48 CFR 242.705-1 - Contracting officer determination procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracting officer determination procedure. 242.705-1 Section 242.705-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES...

30 CFR 207.5 - Contract and sales agreement retention.

Code of Federal Regulations, 2010 CFR

2010-07-01

... production are to be maintained by the lessee and made available upon request during normal working hours to... a reasonable period of time, as determined by MMS. Any oral sales arrangement negotiated by the...

Capacitively coupled EMG detection via ultra-low-power microcontroller STFT.

PubMed

Roland, Theresa; Baumgartner, Werner; Amsuess, Sebastian; Russold, Michael F

2017-07-01

As motion artefacts are a major problem with electromyography sensors, a new algorithm is developed to differentiate artefacts to contraction EMG. The performance of myoelectric prosthesis is increased with this algorithm. The implementation is done for an ultra-low-power microcontroller with limited calculation resources and memory. Short Time Fourier Transformation is used to enable real-time application. The sum of the differences (SOD) of the currently measured EMG to a reference contraction EMG is calculated. The SOD is a new parameter introduced for EMG classification. The satisfactory error rates are determined by measurements done with the capacitively coupling EMG prototype, recently developed by the research group.

Neuromuscular performance of maximal voluntary explosive concentric contractions is influenced by angular acceleration.

PubMed

Hahn, D; Bakenecker, P; Zinke, F

2017-12-01

Torque production during maximal voluntary explosive contractions is considered to be a functionally more relevant neuromuscular measure than steady-state torque, but little is known about accelerated concentric contractions. This study investigated torque, muscle activity, and fascicle behavior during isometric and fast concentric contractions of quadriceps femoris. Ten participants performed maximal voluntary explosive isometric, isovelocity, and additional concentric knee extensions at angular accelerations ranging from 700 to 4000° s -2 that resulted in an angular velocity of 300° s -1 at 40° knee flexion. Concentric torque at 40° knee flexion was corrected for inertia, and the corresponding isometric torque was matched to the time when the target knee angle of 40° was reached during concentric contractions. Electromyography of quadriceps femoris and hamstrings and ultrasound of vastus lateralis were measured to determine muscle activity, fascicle length, and fascicle velocity (FV). The faster the acceleration, the more torque was produced during concentric contractions at 40° knee flexion, which was accompanied by a reduction in FV. In comparison with isometric conditions, concentric quadriceps muscle activity was increased and torque during accelerations ≥3000° s -2 equaled the time-matched isometric torque. Our results provide novel evidence that acceleration influences torque production during maximal voluntary explosive concentric contractions. This is suggested to be due to series elasticity and reduced force depression. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

48 CFR 42.705-1 - Contracting officer determination procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... will be contracting officer or auditor determined. (4) Educational institutions (see 42.705-3). (5... proposal to the contracting officer (or cognizant Federal agency official) and to the cognizant auditor. (i... business type, size, and accounting system capabilities. The contractor, contracting officer, and auditor...

48 CFR 48.104-1 - Determining sharing period.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT VALUE ENGINEERING Policies and Procedures 48.104-1 Determining sharing period. (a.... (c) For engineering-development contracts and contracts containing low-rate-initial-production or...

Writing a job description/contract for a dental hygienist in dental practice.

PubMed

Blair, D J

1997-01-01

THE JOB DESCRIPTION: Describes how the dentist wants to use that person in the practice, adapted by communication and the resourcefulness of the employee. A hygienist is trained with a particular philosophy. The practice philosophy is generally something that has developed without the help of the hygienist's philosophy, but none the less both need active manipulation and respect. The job description described here has changed rapidly and will continue to evolve as we communicate, educate and change to try to improve our overall service and delivery. THE CONTRACT: Now that an understanding has been reached as to both hygienist's's and dentist expectations, a contract for employment is required. The Employment Act in New Zealand has determined that this is essential. It is difficult to determine a contract without the job description. A contract should have a time-frame and be concise. It should be firm and binding whereas the job description should be flexible. The contract should have a clause which takes account of the flexibility and developing nature of the job description. The job description can be a baseline not only for the hygienist, but for the communication necessary to develop and improve team systems and programmes. The contract and its renewal is just one of those systems. The changes to a contract can only occur on renewal, but this doesn't mean to say you can't both tear it up and start again. The rapid changes that occur in modern dentistry cannot all be accounted for and there will always be the missing clauses. Your teamwork and communication will reduce these, and help promote a more satisfactory, comfortable and less stressful work environment.

High-current discharge channel contraction in high density gas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutberg, Ph. G.; Bogomaz, A. A.; Pinchuk, M. E.

Research results for discharges at current amplitudes of 0.5-1.6 MA and current rise rate of {approx}10{sup 10} A/s are presented. The discharge is performed in the hydrogen environment at the initial pressure of 5-35 MPa. Initiation is implemented by a wire explosion. The time length of the first half-period of the discharge current is 70-150 {mu}s. Under such conditions, discharge channel contraction is observed; the contraction is followed by soft x-ray radiation. The phenomena are discussed, which are determined by high density of the gas surrounding the discharge channel. These phenomena are increase of the current critical value, where themore » channel contraction begins and growth of temperature in the axis region of the channel, where the initial density of the gas increases.« less

48 CFR 47.207-2 - Duration of contract and time of performance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... time of performance. 47.207-2 Section 47.207-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TRANSPORTATION Contracts for Transportation or for Transportation-Related Services 47.207-2 Duration of contract and time of performance. The contracting officer shall— (a...

48 CFR 2816.602 - Labor-hour contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Labor-hour contracts. 2816... and Contract Types TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 2816.602 Labor-hour contracts. The limitations set forth in 2816.601 for time-and-material contracts also apply...

48 CFR 16.602 - Labor-hour contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Labor-hour contracts. 16... METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 16.602 Labor-hour contracts. Description. A labor-hour contract is a variation of the time-and-materials...

The price of placements in residential and nursing home care: the effects of contracts and competition.

PubMed

Forder, J; Netten, A

2000-10-01

A variety of contract types are used in the placement of elderly people in residential and nursing care homes in the UK. Contracts vary according to how and when providers are paid. Among other things, prices can be made contingent on the total quantity of service to be purchased and on production cost characteristics. They can be determined at the time of placement or in advance. The primary objective of this paper is to assess the impact of contract choices on the price of placements. Regression analysis was conducted on a final sample of 1780 publicly funded placements made in 18 local authorities in the UK over a 6-month period ending in early 1996. Controlling factors included in the price analysis were production cost indicators and those measuring market competitiveness. Choices of both quantity and cost contingent contracts were found to be significantly associated with placement prices. The findings support the hypothesis that contract payment arrangements have different risk, insurance and information properties, and so have implications for the performance of residential care providers.

41 CFR 50-203.15 - Initiation of proceeding.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations Under the Walsh-Healey Public Contracts Act § 50-203.15 Initiation of proceeding. Wage determination...

25 CFR 900.171 - Will there be a hearing?

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self-Determination Contract § 900.171 Will there be a hearing? Yes. The Deputy Director of...

25 CFR 900.171 - Will there be a hearing?

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self-Determination Contract § 900.171 Will there be a hearing? Yes. The Deputy Director of...

25 CFR 900.171 - Will there be a hearing?

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self-Determination Contract § 900.171 Will there be a hearing? Yes. The Deputy Director of...

25 CFR 900.171 - Will there be a hearing?

Code of Federal Regulations, 2013 CFR

2013-04-01

... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self-Determination Contract § 900.171 Will there be a hearing? Yes. The Deputy Director of...

25 CFR 533.2 - Time for submitting management contracts and amendments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Time for submitting management contracts and amendments. 533.2 Section 533.2 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR MANAGEMENT CONTRACT PROVISIONS APPROVAL OF MANAGEMENT CONTRACTS § 533.2 Time for submitting management contracts and...

48 CFR 22.1008-1 - Obtaining wage determinations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Labor. If the WDOL database does not contain the applicable prevailing wage determination for a contract... employees to be utilized in performance of the contract using the Wage and Hour Division's Service Contract...

Increasing temperature speeds intracellular PO2 kinetics during contractions in single Xenopus skeletal muscle fibers.

PubMed

Koga, S; Wüst, R C I; Walsh, B; Kindig, C A; Rossiter, H B; Hogan, M C

2013-01-01

Precise determination of the effect of muscle temperature (T(m)) on mitochondrial oxygen consumption kinetics has proven difficult in humans, in part due to the complexities in controlling for T(m)-related variations in blood flow, fiber recruitment, muscle metabolism, and contractile properties. To address this issue, intracellular Po(2) (P(i)(O(2))) was measured continuously by phosphorescence quenching following the onset of contractions in single Xenopus myofibers (n = 24) while controlling extracellular temperature. Fibers were subjected to two identical contraction bouts, in random order, at 15°C (cold, C) and 20°C (normal, N; n = 12), or at N and 25°C (hot, H; n = 12). Contractile properties were determined for every contraction. The time delay of the P(i)(O(2)) response was significantly greater in C (59 ± 35 s) compared with N (35 ± 26 s, P = 0.01) and H (27 ± 14 s, P = 0.01). The time constant for the decline in P(i)(O(2)) was significantly greater in C (89 ± 34 s) compared with N (52 ± 15 s; P < 0.01) and H (37 ± 10 s; P < 0.01). There was a linear relationship between the rate constant for P(i)(O(2)) kinetics and T(m) (r = 0.322, P = 0.03). Estimated ATP turnover was significantly greater in H than in C (P < 0.01), but this increased energy requirement alone with increased T(m) could not account for the differences observed in P(i)(O(2)) kinetics among conditions. These results demonstrate that P(i)(O(2)) kinetics in single contracting myofibers are dependent on T(m), likely caused by temperature-induced differences in metabolic demand and by temperature-dependent processes underlying mitochondrial activation at the start of muscle contractions.

25 CFR 900.44 - What minimum general standards apply to all Indian tribe or tribal organization financial...

Code of Federal Regulations, 2014 CFR

2014-04-01

... or tribal organization financial management systems when carrying out a self-determination contract... organization financial management systems when carrying out a self-determination contract? The fiscal control... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...

25 CFR 900.44 - What minimum general standards apply to all Indian tribe or tribal organization financial...

Code of Federal Regulations, 2013 CFR

2013-04-01

... or tribal organization financial management systems when carrying out a self-determination contract... organization financial management systems when carrying out a self-determination contract? The fiscal control... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...

25 CFR 900.44 - What minimum general standards apply to all Indian tribe or tribal organization financial...

Code of Federal Regulations, 2012 CFR

2012-04-01

... or tribal organization financial management systems when carrying out a self-determination contract... organization financial management systems when carrying out a self-determination contract? The fiscal control... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...

25 CFR 900.44 - What minimum general standards apply to all Indian tribe or tribal organization financial...

Code of Federal Regulations, 2011 CFR

2011-04-01

... or tribal organization financial management systems when carrying out a self-determination contract... organization financial management systems when carrying out a self-determination contract? The fiscal control... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...

25 CFR 900.44 - What minimum general standards apply to all Indian tribe or tribal organization financial...

Code of Federal Regulations, 2010 CFR

2010-04-01

... or tribal organization financial management systems when carrying out a self-determination contract... organization financial management systems when carrying out a self-determination contract? The fiscal control... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...

Biomechanical characteristics of skeletal muscles and associations between running speed and contraction time in 8- to 13-year-old children.

PubMed

Završnik, Jernej; Pišot, Rado; Šimunič, Boštjan; Kokol, Peter; Blažun Vošner, Helena

2017-02-01

Objective To investigate associations between running speeds and contraction times in 8- to 13-year-old children. Method This longitudinal study analyzed tensiomyographic measurements of vastus lateralis and biceps femoris muscles' contraction times and maximum running speeds in 107 children (53 boys, 54 girls). Data were evaluated using multiple correspondence analysis. Results A gender difference existed between the vastus lateralis contraction times and running speeds. The running speed was less dependent on vastus lateralis contraction times in boys than in girls. Analysis of biceps femoris contraction times and running speeds revealed that running speeds of boys were much more structurally associated with contraction times than those of girls, for whom the association seemed chaotic. Conclusion Joint category plots showed that contraction times of biceps femoris were associated much more closely with running speed than those of the vastus lateralis muscle. These results provide insight into a new dimension of children's development.

Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle.

PubMed

Roy, Pauline; Rau, Fredérique; Ochala, Julien; Messéant, Julien; Fraysse, Bodvael; Lainé, Jeanne; Agbulut, Onnik; Butler-Browne, Gillian; Furling, Denis; Ferry, Arnaud

2016-01-01

The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy. However, how these therapies reduce the muscle fragility is not clear. To address this question, we first determined the event(s) of the excitation-contraction cycle which is/are altered following lengthening (eccentric) contractions in the mdx muscle. We found that the immediate force drop following lengthening contractions, a widely used measure of muscle fragility, was associated with reduced muscle excitability. Moreover, the force drop can be mimicked by an experimental reduction in muscle excitation of uninjured muscle. Furthermore, the force drop was not related to major neuromuscular transmission failure, excitation-contraction uncoupling, and myofibrillar impairment. Secondly, and importantly, the re-expression of functional truncated dystrophin in the muscle of mdx mice using an exon skipping strategy partially prevented the reductions in both force drop and muscle excitability following lengthening contractions. We demonstrated for the first time that (i) the increased susceptibility to contraction-induced muscle injury in mdx mice is mainly attributable to reduced muscle excitability; (ii) dystrophin-based therapy improves fragility of the dystrophic skeletal muscle by preventing reduction in muscle excitability.

25 CFR 900.175 - Will an appeal hurt an Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2013 CFR

2013-04-01

... organization's position in other contract negotiations? 900.175 Section 900.175 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self...

25 CFR 900.175 - Will an appeal hurt an Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2011 CFR

2011-04-01

... organization's position in other contract negotiations? 900.175 Section 900.175 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self...

25 CFR 900.175 - Will an appeal hurt an Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2014 CFR

2014-04-01

... organization's position in other contract negotiations? 900.175 Section 900.175 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self...

25 CFR 900.175 - Will an appeal hurt an Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2012 CFR

2012-04-01

... organization's position in other contract negotiations? 900.175 Section 900.175 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self...

25 CFR 900.175 - Will an appeal hurt an Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2010 CFR

2010-04-01

... organization's position in other contract negotiations? 900.175 Section 900.175 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals of Emergency Reassumption of Self-Determination Contracts Or Suspensions, Withholding Or Delay of Payments Under A Self...

30 CFR 206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

Code of Federal Regulations, 2010 CFR

2010-07-01

... under an arm's-length transportation contract? 206.110 Section 206.110 Mineral Resources MINERALS... § 206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length transportation contract...

Dark adaptation-induced changes in rod, cone and intrinsically photosensitive retinal ganglion cell (ipRGC) sensitivity differentially affect the pupil light response (PLR).

PubMed

Wang, Bin; Shen, Chao; Zhang, Lei; Qi, Linsong; Yao, Lu; Chen, Jianzhang; Yang, Guoqing; Chen, Tao; Zhang, Zuoming

2015-11-01

Our purpose was to explore pupil light response (PLR) with respect to the change in sensitivity of photoreceptors during various dark adaptation phases and to determine the optimal duration of dark adaptation time before the PLR. The PLR was recorded in 15 healthy subjects and three patients with neural or retinal vision loss after 1-sec blue and red light stimuli of 1, 10, and 100 cd/m(2). The PLR was repeated nine times at different checkpoints during the 40-minute dark adaptation. The transient contraction amplitude, sustained contraction amplitude, and relative sustained contraction ratio of the PLR were analyzed. The increase in the transient contraction amplitude during the entire dark adaptation process was significant (changing up to 45.1 %) in the initial phase of dark adaptation under different stimulus conditions. The changes in the sustained contraction amplitude and the relative sustained contraction ratio were substantial (changing up to 71.0 % and 37.2 % from 1 to 20 minutes of dark adaptation, respectively) under high-intensity blue illumination. The inflection point of the contraction curves in the dark adaptation was 15 or 20 minutes. The patients' PLR results changed in a similar manner. The changes in the sensitivity of different photoreceptors occurred at different rates, and the contraction amplitude of the PLR was significantly affected by the dark adaptation duration. So 20 minutes of dark adaptation before PLR testing was suggested to achieve a consistent and stable pupil response. The dark adaptation effect should be put into consideration when comparing the results from different phases of the PLR test.

Design of inventory pools in spare part support operation systems

NASA Astrophysics Data System (ADS)

Mo, Daniel Y.; Tseng, Mitchell M.; Cheung, Raymond K.

2014-06-01

The objective of a spare part support operation is to fulfill the part request order with different service contracts in the agreed response time. With this objective to achieve different service targets for multiple service contracts and the considerations of inventory investment, it is not only important to determine the inventory policy but also to design the structure of inventory pools and the order fulfilment strategies. In this research, we focused on two types of inventory pools: multiple inventory pool (MIP) and consolidated inventory pool (CIP). The idea of MIP is to maintain separated inventory pools based on the types of service contract, while CIP solely maintains a single inventory pool regardless of service contract. Our research aims to design the inventory pool analytically and propose reserve strategies to manage the order fulfilment risks in CIP. Mathematical models and simulation experiments would be applied for analysis and evaluation.

A snap shot of patients' recall, attitudes, and perceptions of their pain contracts from a family medicine resident outpatient clinic.

PubMed

Bahniwal, Robinder; Sell, Jarrett; Waheed, Abdul

Determine patient recall, attitudes, and perceptions of their pain contract in a family medicine resident out-patient clinic. A cross-sectional study design using a telephone survey to all eligible subjects who signed a hardcopy pain contract from August 29, 2014 to May 19, 2016 at a resident outpatient clinic. Penn State Hershey Family and Community Medicine Residency clinic. All patients who signed a hardcopy pain contract at the practice site who met specific inclusion criteria. What proportions of items are remembered from the standardized Penn State Hershey pain contract and does recall vary with time of contract signing. Patient attitudes and perceptions of their pain contract. Ninety-five percent of patients recalled agreeing to random urine drug screens (UDS) and 60 percent recalled they were not to receive prescriptions from another provider unless approved by their practice site. The recall rate for the remaining 33 items in the contract ranged from 0 percent to 20 percent. The highest recall rate was for contracts signed between 0-3 months. Patient feedback regarding the pain contract was recorded and while five were positive or neutral, 15 patients recorded negative attitudes toward the process, the physician, and/or the UDS. This study highlights limited recall and negative patient attitudes toward the pain contract. Considering the public health concerns with regard to the current opioid epidemic in the United States, additional training of providers, redesign of pain contracts and new models for informing patients about safe chronic pain management may be warranted.

25 CFR 900.131 - What role does the Secretary play during the performance of a self-determination construction...

Code of Federal Regulations, 2012 CFR

2012-04-01

... the Indian tribe or tribal organization is contracting solely to perform construction management... of a self-determination construction contract? 900.131 Section 900.131 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.131 What role...

25 CFR 900.131 - What role does the Secretary play during the performance of a self-determination construction...

Code of Federal Regulations, 2014 CFR

2014-04-01

... the Indian tribe or tribal organization is contracting solely to perform construction management... of a self-determination construction contract? 900.131 Section 900.131 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.131 What role...

25 CFR 900.131 - What role does the Secretary play during the performance of a self-determination construction...

Code of Federal Regulations, 2013 CFR

2013-04-01

... the Indian tribe or tribal organization is contracting solely to perform construction management... of a self-determination construction contract? 900.131 Section 900.131 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.131 What role...

25 CFR 900.189 - Does this coverage extend to subcontractors of self-determination contracts?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Does this coverage extend to subcontractors of self-determination contracts? 900.189 Section 900.189 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... this coverage extend to subcontractors of self-determination contracts? No. Subcontractors or...

48 CFR 22.1008-2 - Section 4(c) successorship with incumbent contractor collective bargaining agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TO GOVERNMENT ACQUISITIONS Service Contract Act of 1965, as Amended 22.1008-2 Section 4(c... contracting officer shall determine whether section 4(c) of the Act affects the new acquisition. The contracting officer shall determine whether there is a predecessor contract covered by the Act and, if so...

25 CFR 12.34 - Do minimum salaries and position classifications apply to a tribe that has contracted or...

Code of Federal Regulations, 2010 CFR

2010-04-01

... a tribe that has contracted or compacted law enforcement under self-determination? 12.34 Section 12.34 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER INDIAN COUNTRY LAW... apply to a tribe that has contracted or compacted law enforcement under self-determination? Any contract...

48 CFR 432.113 - Customary contract financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... financing. 432.113 Section 432.113 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Non-Commercial Item Purchase Financing 432.113 Customary contract financing. The contracting officer may determine the necessity for customary contract financing. The...

78 FR 36199 - Indian Self-Determination and Education Assistance Contracts; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

... 1 to 1040 hours, with an average of 11 hours per response'' it should read ``Estimated Time per Response: Varies from 1 to 1040 hours, with an average of 15.968 hours per response.'' Dated: June 10, 2013...

48 CFR 3016.170 - Contracts with Lead System Integrators.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Contracts with Lead System... Selecting Contract Types 3016.170 Contracts with Lead System Integrators. The contracting officer should... consulted to determine the appropriate contract type and fee structure for use in varied contracts with lead...

48 CFR 3016.170 - Contracts with Lead System Integrators.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Contracts with Lead System... Selecting Contract Types 3016.170 Contracts with Lead System Integrators. The contracting officer should... consulted to determine the appropriate contract type and fee structure for use in varied contracts with lead...

48 CFR 3016.170 - Contracts with Lead System Integrators.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Contracts with Lead System... Selecting Contract Types 3016.170 Contracts with Lead System Integrators. The contracting officer should... consulted to determine the appropriate contract type and fee structure for use in varied contracts with lead...

48 CFR 3016.170 - Contracts with Lead System Integrators.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Contracts with Lead System... Selecting Contract Types 3016.170 Contracts with Lead System Integrators. The contracting officer should... consulted to determine the appropriate contract type and fee structure for use in varied contracts with lead...

48 CFR 3016.170 - Contracts with Lead System Integrators.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contracts with Lead System... Selecting Contract Types 3016.170 Contracts with Lead System Integrators. The contracting officer should... consulted to determine the appropriate contract type and fee structure for use in varied contracts with lead...

48 CFR 731.370 - Predetermined fixed rates for indirect costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts... determining the indirect costs applicable under contracts with educational institutions. ...

48 CFR 731.370 - Predetermined fixed rates for indirect costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts... determining the indirect costs applicable under contracts with educational institutions. ...

25 CFR 900.43 - What are the general financial management system standards that apply to a tribal organization...

Code of Federal Regulations, 2010 CFR

2010-04-01

... standards that apply to a tribal organization carrying out a self-determination contract? 900.43 Section 900... organization carrying out a self-determination contract? A tribal organization shall expend and account for..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION...

25 CFR 900.43 - What are the general financial management system standards that apply to a tribal organization...

Code of Federal Regulations, 2012 CFR

2012-04-01

... standards that apply to a tribal organization carrying out a self-determination contract? 900.43 Section 900... organization carrying out a self-determination contract? A tribal organization shall expend and account for..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION...

25 CFR 900.43 - What are the general financial management system standards that apply to a tribal organization...

Code of Federal Regulations, 2014 CFR

2014-04-01

... standards that apply to a tribal organization carrying out a self-determination contract? 900.43 Section 900... organization carrying out a self-determination contract? A tribal organization shall expend and account for..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION...

25 CFR 900.43 - What are the general financial management system standards that apply to a tribal organization...

Code of Federal Regulations, 2011 CFR

2011-04-01

... standards that apply to a tribal organization carrying out a self-determination contract? 900.43 Section 900... organization carrying out a self-determination contract? A tribal organization shall expend and account for..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION...

25 CFR 900.43 - What are the general financial management system standards that apply to a tribal organization...

Code of Federal Regulations, 2013 CFR

2013-04-01

... standards that apply to a tribal organization carrying out a self-determination contract? 900.43 Section 900... organization carrying out a self-determination contract? A tribal organization shall expend and account for..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION...

25 CFR 900.100 - May the Secretary elect to reacquire excess BIA or IHS property whose title has been transferred...

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION... organization? Yes. When a self-determination contract or grant agreement, or portion—thereof, is retroceded... property; (a) Except as provided in paragraph (b) of this section when a self-determination contract or...

25 CFR 900.100 - May the Secretary elect to reacquire excess BIA or IHS property whose title has been transferred...

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION... organization? Yes. When a self-determination contract or grant agreement, or portion—thereof, is retroceded... property; (a) Except as provided in paragraph (b) of this section when a self-determination contract or...

25 CFR 900.100 - May the Secretary elect to reacquire excess BIA or IHS property whose title has been transferred...

Code of Federal Regulations, 2012 CFR

2012-04-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION... organization? Yes. When a self-determination contract or grant agreement, or portion—thereof, is retroceded... property; (a) Except as provided in paragraph (b) of this section when a self-determination contract or...

25 CFR 900.100 - May the Secretary elect to reacquire excess BIA or IHS property whose title has been transferred...

Code of Federal Regulations, 2014 CFR

2014-04-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION... organization? Yes. When a self-determination contract or grant agreement, or portion—thereof, is retroceded... property; (a) Except as provided in paragraph (b) of this section when a self-determination contract or...

25 CFR 900.100 - May the Secretary elect to reacquire excess BIA or IHS property whose title has been transferred...

Code of Federal Regulations, 2013 CFR

2013-04-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION... organization? Yes. When a self-determination contract or grant agreement, or portion—thereof, is retroceded... property; (a) Except as provided in paragraph (b) of this section when a self-determination contract or...

48 CFR 4.803 - Contents of contract files.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ADMINISTRATIVE MATTERS Government Contract Files 4.803 Contents of contract files. The following are examples of the records normally contained, if applicable, in contract files: (a) Contracting office contract file...) Justifications and approvals, determinations and findings, and associated documents. (3) Evidence of availability...

48 CFR 432.114 - Unusual contract financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Unusual contract financing... CONTRACTING REQUIREMENTS CONTRACT FINANCING Non-Commercial Item Purchase Financing 432.114 Unusual contract financing. The HCA is authorized to approve unusual contract financing. The signed determination and finding...

48 CFR 47.306-1 - Transportation cost determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transportation cost... CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.306-1 Transportation cost determinations. When requesting the transportation officer to assist in evaluating offers, the contracting...

48 CFR 47.306-1 - Transportation cost determinations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Transportation cost... CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.306-1 Transportation cost determinations. When requesting the transportation officer to assist in evaluating offers, the contracting...

48 CFR 47.306-1 - Transportation cost determinations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Transportation cost... CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.306-1 Transportation cost determinations. When requesting the transportation officer to assist in evaluating offers, the contracting...

48 CFR 47.306-1 - Transportation cost determinations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Transportation cost... CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.306-1 Transportation cost determinations. When requesting the transportation officer to assist in evaluating offers, the contracting...

48 CFR 47.306-1 - Transportation cost determinations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Transportation cost... CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.306-1 Transportation cost determinations. When requesting the transportation officer to assist in evaluating offers, the contracting...

Effect of prolonged general anesthesia with sevoflurane and laparoscopic surgery on gastric and small bowel propulsive motility and pH in dogs.

PubMed

Boscan, Pedro; Cochran, Shannon; Monnet, Eric; Webb, Craig; Twedt, David

2014-01-01

To determine if general anesthesia with sevoflurane and laparoscopic surgery changed gastric and small bowel propulsive motility or pH in dogs. Prospective, controlled trial. Twelve, 19-24 months old, female, Treeing Walker Hound dogs, weighing 23-30 kg. Dogs were anesthetized for a median of 8.5 hours during another study to determine the minimum alveolar concentration of sevoflurane using a visceral stimulus. Gastric and small bowel motility were determined using a sensor capsule that measures pressure, pH and temperature. Gastric transit time and motility index were calculated. For 8/12 dogs, gastric motility, pH and transit time were measured. In 4/12 dogs, small bowel motility and pH were measured. Anesthesia decreased gastric and small bowel motility but did not change luminal pH. Mean gastric contraction force decreased from median (range) 11 (8-20) to 3 (1-10) mmHg (p < 0.01) and gastric motility index decreased from 0.63 (0-1.58) to 0 (0-0.31; p = 0.01). Frequency of contractions did not change, 3.7 (1.6-4.4) versus 2.8 (0.1-5.1) contractions minute(-1) (p = 0.1). Gastric motility returned to normal 12-15 hours following anesthesia. Gastric emptying was prolonged from 12 (5.3-16) to 49 (9.75-56.25) hours (p < 0.01). Mean small bowel contraction force decreased from 34 (24-37) to 3 (0.9-17) mmHg (p < 0.02) and motility index decreased from 3.75 (1-4.56) to 0 (0-1.53; p = 0.02). Frequency of contractions did not change, 0.5 (0.3-1.4) versus 1.4 (0.3-4.6) contractions minute(-1) (p = 0.11). Small bowel motility returned within 2 hours after anesthesia. Laparoscopy did not result in changes to gastric or small bowel parameters beyond those produced by general anesthesia. The force of gastric and small bowel contractions decreased during sevoflurane anesthesia for laparoscopy. Although gastric motility returned to normal within 12-15 hours the impairment of gastric emptying lasted 30-40 hours, predisposing dogs to postoperative ileus. © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro

PubMed Central

Kirschstein, Timo; Protzel, Chris; Porath, Katrin; Sellmann, Tina; Köhling, Rüdiger; Hakenberg, Oliver W

2014-01-01

Aim: Activation of muscarinic receptors on the detrusor smooth muscle is followed by contraction, which involves both myosin light chain kinase (MLCK) and Rho kinase (ROCK). The aim of this study was to determine the relative contributions of MLCK and ROCK to carbachol-induced contraction of human detrusor smooth muscle in vitro. Methods: Detrusor smooth muscle strips were prepared from the macroscopically unaffected bladder wall of patients underwent cystectomy. The strips were fixed in an organ bath, and carbachol or KCl-induced isometric contractions were measured by force transducers. Results: Addition of carbachol (0.4-4 μmol/L) into the bath induced concentration-dependent contractions of detrusor specimens, which was completely abolished by atropine (1 μmol/L). Pre-incubation of detrusor specimens with either the MLCK inhibitor ML-9 or the ROCK inhibitors HA1100 and Y-27632 (each at 10 μmol/L) significantly blocked carbachol-induced contractions as compared to the time-control experiments. Moreover, MLCK and ROCK inhibition were equally effective in reducing carbachol-induced contractions. The residual carbachol-induced contractions in the presence of both MLCK and ROCK inhibitors were significantly smaller than the contractions obtained when only one enzyme (either MLCK or ROCK) was inhibited, suggesting an additive effect of the two kinases. Interestingly, ROCK-mediated carbachol-induced contractions were positively correlated to the age of patients (r=o.52, P<0.05). Conclusion: Both MLCK and ROCK contribute to carbachol-induced contractions of human detrusor smooth muscle. ROCK inhibitors may be a new pharmacological approach to modulate human bladder hyperactivity. PMID:24122009

Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro.

PubMed

Kirschstein, Timo; Protzel, Chris; Porath, Katrin; Sellmann, Tina; Köhling, Rüdiger; Hakenberg, Oliver W

2014-01-01

Activation of muscarinic receptors on the detrusor smooth muscle is followed by contraction, which involves both myosin light chain kinase (MLCK) and Rho kinase (ROCK). The aim of this study was to determine the relative contributions of MLCK and ROCK to carbachol-induced contraction of human detrusor smooth muscle in vitro. Detrusor smooth muscle strips were prepared from the macroscopically unaffected bladder wall of patients underwent cystectomy. The strips were fixed in an organ bath, and carbachol or KCl-induced isometric contractions were measured by force transducers. Addition of carbachol (0.4-4 μmol/L) into the bath induced concentration-dependent contractions of detrusor specimens, which was completely abolished by atropine (1 μmol/L). Pre-incubation of detrusor specimens with either the MLCK inhibitor ML-9 or the ROCK inhibitors HA1100 and Y-27632 (each at 10 μmol/L) significantly blocked carbachol-induced contractions as compared to the time-control experiments. Moreover, MLCK and ROCK inhibition were equally effective in reducing carbachol-induced contractions. The residual carbachol-induced contractions in the presence of both MLCK and ROCK inhibitors were significantly smaller than the contractions obtained when only one enzyme (either MLCK or ROCK) was inhibited, suggesting an additive effect of the two kinases. Interestingly, ROCK-mediated carbachol-induced contractions were positively correlated to the age of patients (r=o.52, P<0.05). Both MLCK and ROCK contribute to carbachol-induced contractions of human detrusor smooth muscle. ROCK inhibitors may be a new pharmacological approach to modulate human bladder hyperactivity.

Final contract report : real-time EMS helicopter video feasibility study

DOT National Transportation Integrated Search

2001-11-01

The purpose of this project was to determine whether the use of ground-based video imaging by local rescue squad personnel and Pegasus medical staff is technically and organizationally feasible as a tool to improve pre-hospital care provided to crash...

Performance Contracting and Quality Improvement in Outpatient Treatment: Effects on Waiting Time and Length of Stay

PubMed Central

Stewart, Maureen T.; Horgan, Constance M.; Garnick, Deborah W.; Ritter, Grant; McLellan, A. Thomas

2012-01-01

We evaluate effects of a performance contract (PC) implemented in Delaware in 2001 and participation in quality improvement (QI) programs on waiting time for treatment and length of stay (LOS) using client treatment episode level data from Delaware (n = 12,368) and Maryland (n = 147,151) for 1998 – 2006. Results of difference-in-difference analyses indicate waiting time declined 13 days following the PC, after controlling for client characteristics and historical trends. Participation in the PC and a formal QI program was associated with a decrease of 20 days. LOS increased 22 days under the PC and 24 days under the PC and QI programs, after controlling for client characteristics. The PC and QI program were associated with improvements in LOS and waiting time, although we cannot determine which aspects of the programs (incentives, training, monitoring) resulted in these changes. PMID:22445031

29 CFR 4.142 - Contracts in an indefinite amount.

Code of Federal Regulations, 2010 CFR

2010-07-01

... McNamara-O'Hara Service Contract Act Determining Amount of Contract § 4.142 Contracts in an indefinite amount. (a) Every contract subject to this Act which is indefinite in amount is required to contain the....), a case arising under the Walsh-Healey Public Contracts Act. Such a contract, which may be in the...

48 CFR 1316.405-2 - Cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Cost-plus-award-fee... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1316.405-2 Cost-plus-award-fee contracts. Insert clause 1352.216-72, Determination of Award Fee, in all cost-plus-award-fee contracts. ...

Protecting the Environment Through Public Procurement Law - The Case of Poland

NASA Astrophysics Data System (ADS)

Kozik, Renata; Karasińska-Jaśkowiec, Izabela

2016-10-01

The article presents the results of studies whose aim was to analyse public procurement procedures in the context of environmental protection, especially wastewater infrastructure, performed in the selected Polish municipalities. The selection criterions were the time of public procurement procedure - from 2009 until 2015 and that the contract was cofinanced by the European Union funds. The contracting authorities responsible for awarding specific contracts, were asked series of detailed questions about the environmental criteria and requirements contained in the tender documents for the construction contracts related to the wastewater infrastructure. The aim of the detailed study was to determine whether the actions taken by the contracting authorities in a tender procedure for the construction or operation of wastewater infrastructure include environmental issues. Authors examine also the applicable public procurement law regulation in Poland and Europe in the context of sustainable development and environmental protection. The study of public procurement law was to check whether the law regulation fully takes into account the environmental aspects of the planned investments. On this basis, conclusions have been made that laws are consistent and do not constitute an obstacle to awarding a contract positively affecting the environment.

48 CFR 501.404-70 - Contract action.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract action. 501.404... Contract action. Contract action. A contract action, for the purpose of determining whether an individual or class deviation is appropriate, has the same meaning as that used for reporting contract actions...

77 FR 43780 - Federal Acquisition Regulation; Changes to Time-and-Materials and Labor-Hour Contracts and Orders

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... Federal Acquisition Regulation; Changes to Time-and-Materials and Labor-Hour Contracts and Orders AGENCIES... changing the scope of work for a time-and-materials (T&M) or labor-hour (LH) contract or order. DATES...-043, ``Time-and-Materials and Labor-Hour Contracts for Commercial Items'', was published as a final...

Comparing the performance of a new disposable pneumatic tocodynamometer with a standard tocodynamometer.

PubMed

Eswaran, Hari; Wilson, James D; Murphy, Pam; Siegel, Eric R; Lowery, Curtis L

2016-03-01

The goal was to test a newly developed pneumatic tocodynamometer (pTOCO) that is disposable and lightweight, and evaluate its equivalence to the standard strain gauge-based tocodynamometer (TOCO). The equivalence between the devices was determined by both mechanical testing and recording of contractile events on women. The data were recorded simultaneously from a pTOCO prototype and standard TOCO that were in place on women who were undergoing routine contraction monitoring in the Labor and Delivery unit at the University of Arkansas for Medical Sciences. In this prospective equivalence study, the output from 31 recordings on 28 pregnant women that had 171 measureable contractions simultaneously in both types of TOCO were analyzed. The traces were scored for contraction start, peak and end times, and the duration of the event was computed from these times. The response curve to loaded weights and applied pressure were similar for both devices, indicating their mechanical equivalence. The paired differences in times and duration between devices were subjected to mixed-models analysis to test the pTOCO for equivalence with standard TOCOs using the two-one-sided tests procedure. The event times and duration analyzed simultaneously from both TOCO types were all found to be significantly equivalent to within ±10 s (all p-values ≤0.0001). pTOCO is equivalent to the standard TOCO in the detection of the timing and duration of uterine contractions. pTOCO would provide a lightweight, disposable alternative to commercially available standard TOCOs. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

48 CFR 49.109-7 - Settlement by determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-7 Settlement by determination. (a... determination of the amount due consistent with the termination clause, including any cost principles...

36 CFR 223.101 - Determination of purchaser responsibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Timber Sale Contracts Award of Contracts § 223.101 Determination of purchaser responsibility. (a) A Contracting Officer shall not award a timber sale... and governmental business commitments; (3) The purchaser has a satisfactory performance record on...

Collective hydrodynamic communication through ultra-fast contractions

NASA Astrophysics Data System (ADS)

Bhamla, Saad; Mathijssen, Arnold; Prakash, Manu

2017-11-01

The biophysical relationships between physiological sensors and actuators were fundamental to the development of early life forms, as responding to external stimuli promptly is key to survival. We study an unusual protist Spirostomum ambiguum, a single-celled organism that can grow up to 4mm in size, visible to the naked eye, as a model system for impulsive systems. Coiling its cytoskeleton, this ciliate can contract its long body within milliseconds, one of the fastest accelerations known in cell biology. We demonstrate that these rapid contractions generate long-ranged vortex flows that can trigger other cells to contract, repeatedly, which collectively leads to an ultra-fast hydrodynamic signal transduction across a colony that moves hundreds of times faster than the swimming speed. By combining high-speed PIV experiments and analytical modelling we determine the critical rheosensitivity required to sustain these signal waves. Whereas the biological motive is not fully understood, contractions are known to release toxins from membrane-bound extrusomes, thus we hypothesize that synchronised discharges could facilitate the repulsion of large-scale predators cooperatively. Please also see our other talk ``Rheosensing by impulsive cells at intermediate Reynolds numbers''.

Bub2 regulation of cytokinesis and septation in budding yeast

PubMed Central

Park, Su Young; Cable, Addie E; Blair, Jessica; Stockstill, Katherine E; Shannnon, Katie B

2009-01-01

Background The mitotic exit network (MEN) is required for events at the end of mitosis such as degradation of mitotic cyclins and cytokinesis. Bub2 and its binding partner Bfa1 act as a GTPase activating protein (GAP) to negatively regulate the MEN GTPase Tem1. The Bub2/Bfa1 checkpoint pathway is required to delay the cell cycle in response to mispositioned spindles. In addition to its role in mitotic exit, Tem1 is required for actomyosin ring contraction. Results To test the hypothesis that the Bub2 pathway prevents premature actin ring assembly, we compared the timing of actin ring formation in wild type, bub2Δ, mad2Δ, and bub2Δmad2Δ cells both with and without microtubules. There was no difference in the timing of actin ring formation between wild type and mutant cells in a synchronized cell cycle. In the presence of nocodazole, both bub2Δ and mad2Δ cells formed rings after a delay of the same duration. Double mutant bub2Δmad2Δ and bfa1Δmad2Δ cells formed rings at the same time with and without nocodazole. To determine if Bub2 has an effect on actomyosin ring contraction through its regulation of Tem1, we used live cell imaging of Myo1-GFP in a bub2Δ strain. We found a significant decrease in the total time of contraction and an increase in rate of contraction compared to wild type cells. We also examined myosin contraction using Myo1-GFP in cells overexpressing an epitope tagged Bub2. Surprisingly, overexpression of Bub2 also led to a significant increase in the rate of contraction, as well as morphological defects. The chained cell phenotype caused by Bub2 overexpression could be rescued by co-overexpression of Tem1, and was not rescued by deletion of BFA1. Conclusion Our data indicate that the Bub2 checkpoint pathway does not have a specific role in delaying actin ring formation. The observed increase in the rate of myosin contraction in the bub2Δ strain provides evidence that the MEN regulates actomyosin ring contraction. Our data suggest that the overexpression of the Bub2 fusion protein acts as a dominant negative, leading to septation defects by a mechanism that is Tem1-dependent. PMID:19490645

Effect of mitomycin-C on contraction and migration of human nasal mucosa fibroblasts: implications in dacryocystorhinostomy.

PubMed

Kumar, Vinay; Ali, Mohammad Javed; Ramachandran, Charanya

2015-09-01

To determine the effect of mitomycin-C (MMC) on the contraction and migration of human nasal mucosal fibroblasts (HNMFs) in vitro in order to identify the least concentration of MMC required to prevent cicatrix development following dacryocystorhinostomy (DCR). Primary cultures of HNMFs were established from nasal mucosal tissues of patients undergoing DCR. Myofibroblast transformation of HNMFs was induced using transforming growth factor-β (TGF-β1) and confirmed by immunostaining for α-smooth muscle actin (α-SMA). Collagen gel contraction assay was employed to study contraction in the presence or absence of TGF-β1 (5 and 10 ng/mL) and MMC (0.2 and 0.4 mg/mL). Scratch wound assay was employed to determine the influence of MMC treatment on cell migration. Quantification of gel contraction and wound closure was done using Image J software. α-SMA expression increased with TGF-β1 treatment in a time- and dose-dependent manner indicating myofibroblast transformation of HNMFs. MMC inhibited TGF-β1- induced collagen gel contraction in a dose-dependent manner (0.4 mg/mL>0.2 mg/mL). Further, there was a decrease in the migration of MMC-treated HNMFs, resulting in delayed wound closure that corroborated with the loss of actin stress fibres. MMC successfully inhibited TGF-β1-induced myofibroblast transformation, collagen gel contraction and significantly reduced the migration of HNMFs to cover the wound even at a low concentration of 0.2 mg/mL. This study provides evidence that low concentration and short duration of MMC treatment is efficient in reducing increased contraction and migration of HMNFs in response to injury. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

48 CFR 752.7035 - Public notices.

Code of Federal Regulations, 2011 CFR

2011-10-01

... notices. The following clause is for use when the cognizant technical office determines that the contract... to time, to announce progress and accomplishments. Press releases or other public notices should... cognizant technical officer and to USAID's Legislative and Public Affairs (LPA) as far in advance of release...

48 CFR 13.101 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... before rejecting a quotation, oral or written, from a small business concern determined to be... contracting officer receives authorization from a fiscal and accounting officer to obligate funds on purchase documents against a specified lump sum of funds reserved for the purpose for a specified period of time...

25 CFR 900.245 - What obligation does the Indian tribe or tribal organization have with respect to returning...

Code of Federal Regulations, 2012 CFR

2012-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND... improvements borne by the Indian tribe or tribal organization, in excess of $5,000 at the time of the...

25 CFR 900.245 - What obligation does the Indian tribe or tribal organization have with respect to returning...

Code of Federal Regulations, 2010 CFR

2010-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND... improvements borne by the Indian tribe or tribal organization, in excess of $5,000 at the time of the...

25 CFR 900.245 - What obligation does the Indian tribe or tribal organization have with respect to returning...

Code of Federal Regulations, 2011 CFR

2011-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND... improvements borne by the Indian tribe or tribal organization, in excess of $5,000 at the time of the...

25 CFR 900.245 - What obligation does the Indian tribe or tribal organization have with respect to returning...

Code of Federal Regulations, 2014 CFR

2014-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND... improvements borne by the Indian tribe or tribal organization, in excess of $5,000 at the time of the...

25 CFR 900.245 - What obligation does the Indian tribe or tribal organization have with respect to returning...

Code of Federal Regulations, 2013 CFR

2013-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND... improvements borne by the Indian tribe or tribal organization, in excess of $5,000 at the time of the...

13 CFR 121.404 - When does SBA determine the size status of a business concern?

Code of Federal Regulations, 2011 CFR

2011-01-01

... as part of its response to the solicitation for the order. (vi) A Blanket Purchase Agreement (BPA) is not a contract. Goods and services are acquired under a BPA when an order is issued. Thus, a concern's size may not be determined based on its size at the time of a response to a solicitation for a BPA. (h...

13 CFR 121.404 - When does SBA determine the size status of a business concern?

Code of Federal Regulations, 2010 CFR

2010-01-01

... as part of its response to the solicitation for the order. (vi) A Blanket Purchase Agreement (BPA) is not a contract. Goods and services are acquired under a BPA when an order is issued. Thus, a concern's size may not be determined based on its size at the time of a response to a solicitation for a BPA. (h...

[Myocardial contractility and hemodynamics in hypothyroidism].

PubMed

Selivonenko, V G

1977-01-01

The author determined the phasic structure of the systole of the left ventricle by the method of polycardiography and hemodynamics in 20 patients suffering from hypothyrodism. Blood plasma and erythrocyte electrolytes were examined at the same time. Patients with hypothyroidism displayed a phasic syndrome of hypodynamia and a marked correlation between the phase of the synchronous contraction, the period of ejection, the strength of contraction of the left ventricle and the electrolyte content. Sodium and magnesium produced the greatest influence on the phasic structure of the systole; potassium and calcium had a lesser effect. The heart stroke volume diminished; as to the cardiac index, expenditure of the energy of cardiac contractions directed to the maintenance of movement of 1 litre of the minute blood volume; the external work, and the peripheral vascular resistance displayed no significant change.

The Role of Future Time Perspective in Psychological Contracts: A Study among Older Workers

ERIC Educational Resources Information Center

Bal, P. Matthijs; Jansen, Paul G. W.; van der Velde, Mandy E. G.; de Lange, Annet H.; Rousseau, Denise M.

2010-01-01

Using a sample of post-retirement workers (N = 176), this study investigated the role of future time perspective (FTP) in psychological contracts. The study aimed to test: (i) whether future time perspective is related to employer psychological contract fulfillment and (ii) whether it moderates relations between psychological contract fulfillment…

48 CFR 17.206 - Evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracting officer. An example of a circumstance that may support a determination not to evaluate offers for... 17.206 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.206 Evaluation. (a) In awarding the basic contract...

36 CFR 223.101 - Determination of purchaser responsibility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... purchaser has a satisfactory performance record on timber sale contracts. A prospective purchaser that is or... AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL PRODUCTS Timber Sale Contracts Award of Contracts § 223.101 Determination of purchaser responsibility. (a...

48 CFR 1615.404-4 - Profit.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracts by use of a weighted guidelines structured approach. The service charge so determined will be the... 1615.404-4 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Contract Pricing 1615.404-4 Profit. (a) When the pricing of FEHB Program contracts is determined by cost...

48 CFR 1615.404-4 - Profit.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracts by use of a weighted guidelines structured approach. The service charge so determined will be the... 1615.404-4 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Contract Pricing 1615.404-4 Profit. (a) When the pricing of FEHB Program contracts is determined by cost...

48 CFR 622.404-7 - Correction of wage determinations containing clerical errors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts Involving Construction 622.404-7 Correction of wage determinations containing clerical errors. The cognizant contracting activity is the contracting agency for the purposes of FAR 22...

Aspects of research and development contract terms in the bio/pharmaceutical sector.

PubMed

Banerjee, Tannista

2012-01-01

The cost of new drug development is increasing every year. Pharmaceutical companies use R&D joint ventures, mergers, and outsource different stages of pharmaceutical R&D activities for a faster and cost minimizing method of innovation. Pharmaceutical companies outsource R&D activities to independent small biotech or pharmaceutical companies that specialize in different stages of pharmaceutical R&D. This chapter examines the determinants of the payment structure of research contracts between large bio/pharmaceutical companies and specialized research firms. Determinants of R&D contracts are analyzed using detailed R&D contract data between bio/pharmaceutical companies and independent research firms for 10 years. A multinomial logit model is used in order to understand the determinants of three different types of contracts; royalty contracts, fixed payment contracts, and the mixed contracts. Under uncertainty, the likelihood of a royalty contract rises for the early stages of the research and with the patent stock of the research firm. It is more likely to observe both royalty and fixed payment if the pharmaceutical client has past contracts with the same research firm. The results also suggest that if Food and Drug Administration (FDA) is more stringent in any disease area in reviewing the new drug application, then the likelihood of signing pure royalty contract decreases. Understanding the nature of R&D contracts and the effects of FDA's behavior on the pharmaceutical R&D contract is important because these contracts not only affect the cost of new drug invention but also the quality and the rate of invention. VALUE: Results are useful for both the pharmaceutical companies and the economic/business researchers.

Integration of active pauses and pattern of muscular activity during computer work.

PubMed

St-Onge, Nancy; Samani, Afshin; Madeleine, Pascal

2017-09-01

Submaximal isometric muscle contractions have been reported to increase variability of muscle activation during computer work; however, other types of active contractions may be more beneficial. Our objective was to determine which type of active pause vs. rest is more efficient in changing muscle activity pattern during a computer task. Asymptomatic regular computer users performed a standardised 20-min computer task four times, integrating a different type of pause: sub-maximal isometric contraction, dynamic contraction, postural exercise and rest. Surface electromyographic (SEMG) activity was recorded bilaterally from five neck/shoulder muscles. Root-mean-square decreased with isometric pauses in the cervical paraspinals, upper trapezius and middle trapezius, whereas it increased with rest. Variability in the pattern of muscular activity was not affected by any type of pause. Overall, no detrimental effects on the level of SEMG during active pauses were found suggesting that they could be implemented without a cost on activation level or variability. Practitioner Summary: We aimed to determine which type of active pause vs. rest is best in changing muscle activity pattern during a computer task. Asymptomatic computer users performed a standardised computer task integrating different types of pauses. Muscle activation decreased with isometric pauses in neck/shoulder muscles, suggesting their implementation during computer work.

Spatial and temporal traction response in human airway smooth muscle cells

NASA Technical Reports Server (NTRS)

Tolic-Norrelykke, Iva Marija; Butler, James P.; Chen, Jianxin; Wang, Ning

2002-01-01

Tractions that cells exert on their substrates are essential in cell spreading, migration, and contraction. These tractions can be determined by plating the cells on a flexible gel and measuring the deformation of the gel by using fluorescent beads embedded just below the surface of the gel. In this article we describe the image correlation method (ICM) optimized for determining the displacement field of the gel under a contracting cell. For the calculation of the traction field from the displacement field we use the recently developed method of Fourier transform traction cytometry (FTTC). The ICM and FTTC methods are applied to human airway smooth muscle cells during stimulation with the contractile agonist histamine or the relaxing agonist isoproterenol. The overall intensity of the cell contraction (the median traction magnitude, the energy transferred from the cell to the gel, and the net contractile moment) increased after activation with histamine, and decreased after treatment with isoproterenol. Cells exhibited regional differences in the time course of traction during the treatment. Both temporal evolution and magnitude of traction increase induced by histamine varied markedly among different cell protrusions, whereas the nuclear region showed the smallest response. These results suggest that intracellular mediators of cell adhesion and contraction respond to contractile stimuli with different rates and intensities in different regions of the cell.

Method and apparatus for determining and utilizing a time-expanded decision network

NASA Technical Reports Server (NTRS)

de Weck, Olivier (Inventor); Silver, Matthew (Inventor)

2012-01-01

A method, apparatus and computer program for determining and utilizing a time-expanded decision network is presented. A set of potential system configurations is defined. Next, switching costs are quantified to create a "static network" that captures the difficulty of switching among these configurations. A time-expanded decision network is provided by expanding the static network in time, including chance and decision nodes. Minimum cost paths through the network are evaluated under plausible operating scenarios. The set of initial design configurations are iteratively modified to exploit high-leverage switches and the process is repeated to convergence. Time-expanded decision networks are applicable, but not limited to, the design of systems, products, services and contracts.

41 CFR 109-40.109 - Utilization of special contracts and agreements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Provision § 109-40.109 Utilization of special contracts and agreements. From time to time special... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Utilization of special contracts and agreements. 109-40.109 Section 109-40.109 Public Contracts and Property Management Federal...

Tendon Contraction After Cyclic Elongation Is an Age-Dependent Phenomenon: In Vitro and In Vivo Comparisons.

PubMed

Lavagnino, Michael; Bedi, Asheesh; Walsh, Christopher P; Sibilsky Enselman, Elizabeth R; Sheibani-Rad, Shahin; Arnoczky, Steven P

2014-06-01

Tendons are viscoelastic tissues that deform (elongate) in response to cyclic loading. However, the ability of a tendon to recover this elongation is unknown. Tendon length significantly increases after in vivo or in vitro cyclic loading, and the ability to return to its original length through a cell-mediated contraction mechanism is an age-dependent phenomenon. Controlled laboratory study. In vitro, rat tail tendon fascicles (RTTfs) from Sprague-Dawley rats of 3 age groups (1, 3, and 12 months) underwent 2% cyclic strain at 0.17 Hz for 2 hours, and the percentages of elongation were determined. After loading, the RTTfs were suspended for 3 days under tissue culture conditions and photographed daily to determine the amount of length contraction. In vivo, healthy male participants (n = 29; age, 19-49 years) had lateral, single-legged weightbearing radiographs taken of the knee at 60° of flexion immediately before, immediately after, and 24 hours after completing eccentric quadriceps loading exercises on the dominant leg to fatigue. Measurements of patellar tendon length were taken from the radiographs, and the percentages of tendon elongation and subsequent contraction were calculated. In vitro, cyclic loading increased the length of all RTTfs, with specimens from younger (1 and 3 months) rats demonstrating significantly greater elongation than those from older (12 months) rats (P = .009). The RTTfs contracted to their original length significantly faster (P < .001) and in an age-dependent fashion, with younger animals contracting faster. In vivo, repetitive eccentric loading exercises significantly increased patellar tendon length (P < .001). Patellar tendon length decreased 24 hours after exercises (P < .001) but did not recover completely (P < .001). There was a weak but significant (R (2) = 0.203, P = .014) linear correlation between the amount of tendon contraction and age, with younger participants (<30 years) demonstrating significantly more contraction (P = .014) at 24 hours than older participants (>30 years). Cyclic tendon loading results in a significant increase in tendon elongation under both in vitro and in vivo conditions. Tendons in both conditions demonstrated an incomplete return to their original length after 24 hours, and the extent of this return was age dependent. The age- and time-dependent contraction of tendons, elongated after repetitive loading, could result in transient alterations in the mechanobiological environment of tendon cells. This, in turn, could induce the onset of catabolic changes associated with the pathogenesis of tendinopathy. These results suggest the importance of allowing time for contraction between bouts of repetitive exercise and may explain why age is a predisposing factor in tendinopathy. © 2014 The Author(s).

29 CFR 4.140 - Significance of contract amount.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Significance of contract amount. 4.140 Section 4.140 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Determining Amount of Contract § 4.140 Significance of contract amount...

25 CFR 900.111 - What activities of construction programs are contractible?

Code of Federal Regulations, 2010 CFR

2010-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...? The Secretary shall, upon the request of any Indian tribe or tribal organization authorized by tribal resolution, enter into a self-determination contract to plan, conduct, and administer construction programs...

25 CFR 900.54 - Should the property management system prescribe internal controls?

Code of Federal Regulations, 2012 CFR

2012-04-01

... organization's self-determination contract(s) until the property is declared excess to the needs of the... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Property Management...

25 CFR 900.111 - What activities of construction programs are contractible?

Code of Federal Regulations, 2011 CFR

2011-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...? The Secretary shall, upon the request of any Indian tribe or tribal organization authorized by tribal resolution, enter into a self-determination contract to plan, conduct, and administer construction programs...

25 CFR 900.54 - Should the property management system prescribe internal controls?

Code of Federal Regulations, 2014 CFR

2014-04-01

... organization's self-determination contract(s) until the property is declared excess to the needs of the... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Property Management...

25 CFR 900.111 - What activities of construction programs are contractible?

Code of Federal Regulations, 2013 CFR

2013-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...? The Secretary shall, upon the request of any Indian tribe or tribal organization authorized by tribal resolution, enter into a self-determination contract to plan, conduct, and administer construction programs...

25 CFR 900.111 - What activities of construction programs are contractible?

Code of Federal Regulations, 2012 CFR

2012-04-01

... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND...? The Secretary shall, upon the request of any Indian tribe or tribal organization authorized by tribal resolution, enter into a self-determination contract to plan, conduct, and administer construction programs...

25 CFR 900.54 - Should the property management system prescribe internal controls?

Code of Federal Regulations, 2013 CFR

2013-04-01

... organization's self-determination contract(s) until the property is declared excess to the needs of the... HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems Property Management...

48 CFR 622.404-3 - Procedures for requesting wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... STATE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Labor Standards for Contracts Involving Construction 622.404-3 Procedures for requesting wage determinations. The cognizant contracting activity (see 601.603-70) is the contracting agency for the purposes of 22.404-3(b) and (d). [53...

48 CFR 52.232-7 - Payments under Time-and-Materials and Labor-Hour Contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-Materials and Labor-Hour Contracts. 52.232-7 Section 52.232-7 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.232-7 Payments under Time-and-Materials and Labor-Hour Contracts. As prescribed in 32.111(a)(7), insert the following clause: Payments Under Time-and-Materials and Labor-Hour Contracts...

7 CFR 1430.202 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... determined by CCC, produce and market milk commercially produced from cows, and whose production facilities.... Eligible production means milk that was produced at a time relevant to this program by cows in the United... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS DAIRY PRODUCTS Milk Income Loss Contract Program § 1430.202...

48 CFR 9.104-3 - Application of standards.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., that will be in existence at the time of contract award, to rent, purchase, or otherwise acquire the... requires a subcontracting plan pursuant to Subpart 19.7, The Small Business Subcontracting Program, the... prospective contractor's responsibility. (d)(1) Small business concerns. Upon making a determination of...

Determination of coronal magnetic fields from vector magnetograms

NASA Technical Reports Server (NTRS)

Mikic, Zoran

1993-01-01

This report covers technical progress during the second year of the contract entitled 'Determination of Coronal Magnetic Fields from Vector Magnetograms,' NASW-4728, between NASA and Science Applications International Corporation, and covers the period January 1, 1993 to December 31, 1993. Under this contract SAIC has conducted research into the determination of coronal magnetic fields from vector magnetograms, including the development and application of algorithms to determine force-free coronal fields above selected observations of active regions. The contract began on June 30, 1992 and has a completion date of December 31, 1994. This contract is a continuation of work started in a previous contract, NASW-4571, which covered the period November 15, 1990 to December 14, 1991. During this second year we have concentrated on studying additional active regions and in using the estimated coronal magnetic fields to compare to coronal features inferred from observations.

Essays on Mathematical Optimization for Residential Demand Response in the Energy Sector

NASA Astrophysics Data System (ADS)

Palaparambil Dinesh, Lakshmi

In the electric utility industry, it could be challenging to adjust supply to match demand due to large generator ramp up times, high generation costs and insufficient in-house generation capacity. Demand response (DR) is a technique for adjusting the demand for electric power instead of the supply. Direct Load Control (DLC) is one of the ways to implement DR. DLC program participants sign up for power interruption contracts and are given financial incentives for curtailing electricity usage during peak demand time periods. This dissertation studies a DLC program for residential air conditioners using mathematical optimization models. First, we develop a model that determines what contract parameters to use in designing contracts between the provider and residential customers, when to turn which power unit on or off and how much power to cut during peak demand hours. The model uses information on customer preferences for choice of contract parameters such as DLC financial incentives and energy usage curtailment. In numerical experiments, the proposed model leads to projected cost savings of the order of 20%, compared to a current benchmark model used in practice. We also quantify the impact of factors leading to cost savings and study characteristics of customers picked by different contracts. Second, we study a DLC program in a macro economic environment using a Computable General Equilibrium (CGE) model. A CGE model is used to study the impact of external factors such as policy and technology changes on different economic sectors. Here we differentiate customers based on their preference for DLC programs by using different values for price elasticity of demand for electricity commodity. Consequently, DLC program customers could substitute demand for electricity commodity with other commodities such as transportation sector. Price elasticity of demand is calculated using a novel methodology that incorporates customer preferences for DLC contracts from the first model. The calculation of elasticity based on our methodology is useful since the prices of commodities are not only determined by aggregate demand and supply but also by customers' relative preferences for commodities. In addition to this we quantify the indirect substitution and rebound effects on sectoral activity levels, incomes and prices based on customer differences, when DLC is implemented.

29 CFR 4.52 - Fringe benefit determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Wage Determination Procedures § 4.52 Fringe benefit determinations. (a) Wage determinations issued pursuant to the Service Contract Act ordinarily contain provisions for vacation and holiday benefits prevailing in the locality. In...

24 CFR 983.204 - When HAP contract is executed.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false When HAP contract is executed. 983... When HAP contract is executed. (a) PHA inspection of housing. (1) Before execution of the HAP contract... into a HAP contract for any contract unit until the PHA has determined that the unit complies with the...

Mediation of acetylcholine and substance P induced contractions by myosin light chain phosphorylation in feline colonic smooth muscle.

PubMed

Washabau, Robert J; Holt, David E; Brockman, Daniel J

2002-05-01

To determine the role of myosin light chain phosphorylation in feline colonic smooth muscle contraction. Colonic tissue was obtained from eight 12- to 24-month-old cats. Colonic longitudinal smooth muscle strips were attached to isometric force transducers for measurements of isometric stress. Myosin light chain phosphorylation was determined by isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Stress and phosphorylation were determined following stimulation with ACh or SP, in the absence or presence of a calmodulin antagonist (W-7; 0.1 to 1.0 mM), myosin light chain kinase inhibitor (ML-9; 1 to 10 microM), or extracellular calcium free solutions. Unstimulated longitudinal colonic smooth muscle contained low amounts (6.9+/-3.2%) of phosphorylated myosin light chain. Phosphorylation of the myosin light chains was dose and time dependent with maximal values of 58.5% at 30 seconds of stimulation with 100 microM Ach and 60.2% at 45 seconds of stimulation with 100 nM SP Active isometric stress development closely paralleled phosphorylation of the myosin light chains in ACh- or SP-stimulated muscle. W-7 and ML-9 dose dependently inhibited myosin light chain phosphorylation and isometric stress development associated with ACh or SP stimulation. Removal of extracellular calcium inhibited myosin light chain phosphorylation and isometric stress development in ACh-stimulated smooth muscle. Feline longitudinal colonic smooth muscle contraction is calcium-, calmodulin-, and myosin light chain kinase-dependent. Myosin light chain phosphorylation is necessary for the initiation of contraction in feline longitudinal colonic smooth muscle. These findings may prove useful in determining the biochemical and molecular defects that accompany feline colonic motility disorders.

30 CFR 1206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

Code of Federal Regulations, 2013 CFR

2013-07-01

... under an arm's-length transportation contract? 1206.110 Section 1206.110 Mineral Resources OFFICE OF... Oil § 1206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length transportation...

30 CFR 1206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

Code of Federal Regulations, 2014 CFR

2014-07-01

... under an arm's-length transportation contract? 1206.110 Section 1206.110 Mineral Resources OFFICE OF... Oil § 1206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length transportation...

30 CFR 1206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

Code of Federal Regulations, 2012 CFR

2012-07-01

... under an arm's-length transportation contract? 1206.110 Section 1206.110 Mineral Resources OFFICE OF... Oil § 1206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length transportation...

Effects of hypothyroidism on the skeletal muscle blood flow response to contractions.

PubMed

Bausch, L; McAllister, R M

2003-04-01

Hypothyroidism is associated with impaired blood flow to skeletal muscle under whole body exercise conditions. It is unclear whether poor cardiac and/or vascular function account for blunted muscle blood flow. Our experiment isolated a small group of hindlimb muscles and simulated exercise via tetanic contractions. We hypothesized that muscle blood flow would be attenuated in hypothyroid rats (HYPO) compared with euthyroid rats (EUT). Rats were made hypothyroid by mixing propylthiouracil in their drinking water (2.35 x 10-3 mol/l). Treatment efficacy was evidenced by lower serum T3 concentrations and resting heart rates in HYPO (both P<0.05). In the experimental preparation, isometric contractions of the lower right hindlimb muscles at a rate of 30 tetani/min were induced via sciatic nerve stimulation. Regional blood flows were determined by the radiolabelled microsphere method at three time points: rest, 2 min of contractions and 10 min of contractions. Muscle blood flow generally increased from rest ( approximately 5-10 ml/min per 100 g) through contractions for both groups. Further, blood flow during contractions did not differ between groups for any muscle (eg. red section of gastrocnemius muscle; EUT, 59.9 +/- 14.1; HYPO, 61.1 +/- 15.0; NS between groups). These findings indicate that hypothyroidism does not significantly impair skeletal muscle blood flow when only a small muscle mass is contracting. Our findings suggest that impaired blood flow under whole body exercise is accounted for by inadequate cardiac function rather than abnormal vascular function.

Microprocessor controlled movement of liquid gastric content using sequential neural electrical stimulation

PubMed Central

Mintchev, M; Sanmiguel, C; Otto, S; Bowes, K

1998-01-01

Background—Gastric electrical stimulation has been attempted for several years with little success. 
Aims—To determine whether movement of liquid gastric content could be achieved using microprocessor controlled sequential electrical stimulation. 
Methods—Eight anaesthetised dogs underwent laparotomy and implantation of four sets of bipolar stainless steel wire electrodes. Each set consisted of two to six electrodes (10×0.25 mm, 3 cm apart) implanted circumferentially. The stomach was filled with water and the process of gastric emptying was monitored. Artificial contractions were produced using microprocessor controlled phase locked bipolar four second trains of 50 Hz, 14 V (peak to peak) rectangular voltage. In four of the dogs four force transducers were implanted close to each circumferential electrode set. In one gastroparetic patient the effect of direct electrical stimulation was determined at laparotomy. 
Results—Using the above stimulating parameters circumferential gastric contractions were produced which were artificially propagated distally by phase locking the stimulating voltage. Averaged stimulated gastric emptying times were significantly shorter than spontaneus emptying times (t1/2 6.7 (3.0) versus 25.3 (12.9) minutes, p<0.01). Gastric electrical stimulation of the gastroparetic patient at operation produced circumferential contractions. 
Conclusions—Microprocessor controlled electrical stimulation produced artificial peristalsis and notably accelerated the movement of liquid gastric content. 

 Keywords: gastric electrical stimulation; gastric motility PMID:9824339

48 CFR 536.270 - Exercise of options.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Exercise of options. 536... Construction 536.270 Exercise of options. (a) If exercising an option, notify the contractor, in writing, within the time period specified in the contract. (b) Exercise options only after determining that all...

48 CFR 536.270 - Exercise of options.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Exercise of options. 536... Construction 536.270 Exercise of options. (a) If exercising an option, notify the contractor, in writing, within the time period specified in the contract. (b) Exercise options only after determining that all...

48 CFR 536.270 - Exercise of options.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Exercise of options. 536... Construction 536.270 Exercise of options. (a) If exercising an option, notify the contractor, in writing, within the time period specified in the contract. (b) Exercise options only after determining that all...

48 CFR 536.270 - Exercise of options.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Exercise of options. 536... Construction 536.270 Exercise of options. (a) If exercising an option, notify the contractor, in writing, within the time period specified in the contract. (b) Exercise options only after determining that all...

48 CFR 536.270 - Exercise of options.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Exercise of options. 536... Construction 536.270 Exercise of options. (a) If exercising an option, notify the contractor, in writing, within the time period specified in the contract. (b) Exercise options only after determining that all...

26 CFR 1.817A-1 - Certain modified guaranteed contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., other equity instruments, or equity-based derivatives. (5) Current market rate for non-equity-indexed... to time with reference to market values for annual statement purposes. Further, an MGC must provide... policyholder upon surrender is usually increased or decreased by a market value adjustment, which is determined...

The Applied Music (Individual Study) Program.

ERIC Educational Resources Information Center

Texas Education Agency, Austin.

Students in Texas who seek to advance their proficiency in vocal or instrumental performance may participate in the Applied Music (Individual Study) Program. Enrollment in the courses of this program and the establishment of time parameters are determined by contracts between students and schools. The first part of this guide discusses the…

7 CFR 1435.605 - Competitive procedures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... § 1435.605 Competitive procedures. (a) CCC will generally issue tenders for bids, before entering into... the least cost to CCC of removing sugar from the market. (b) CCC may, at times, negotiate contracts directly with sellers or buyers, if CCC determines that such negotiation will result in either reduced...

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers... Confidential Business Information, in all solicitations when the contracting officer has determined that EPA may furnish the contractor with confidential business information which EPA had obtained from third...

48 CFR 32.501-3 - Contract price.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract price. 32.501-3... REQUIREMENTS CONTRACT FINANCING Progress Payments Based on Costs 32.501-3 Contract price. (a) For the purpose of making progress payments and determining the limitation on progress payments, the contract price...

24 CFR 982.454 - Termination of HAP contract: Insufficient funding.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Termination of HAP contract... Assistance Payments Contract and Owner Responsibility § 982.454 Termination of HAP contract: Insufficient funding. The PHA may terminate the HAP contract if the PHA determines, in accordance with HUD requirements...

48 CFR 611.603 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting officers are authorized to sign DO-H8 rated contracts or orders. It is the responsibility of the requirements office to determine which contracts or orders should be rated. All contracts with U.S. firms under the DOSESPP will not necessarily need to be assigned a priority rating. (g) The contracting officer...

48 CFR 611.603 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracting officers are authorized to sign DO-H8 rated contracts or orders. It is the responsibility of the requirements office to determine which contracts or orders should be rated. All contracts with U.S. firms under the DOSESPP will not necessarily need to be assigned a priority rating. (g) The contracting officer...

An Exposition of Fischer's Model of Overlapping Contracts.

ERIC Educational Resources Information Center

Fields, T. Windsor; Hart, William R.

1992-01-01

Suggests how the classic model of overlapping contracts can be incorporated into the contract wage model of aggregate supply. Illustrates dynamics of macroeconomic adjustment following a shock to aggregate demand. Concludes that overlapping contracts do not prolong the adjustment process; rather, the longest remaining contract determines the time…

48 CFR 22.407 - Solicitation provision and contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Adjustment (None or Separately Specified Pricing Method), in solicitations and contracts if the contract is... determines the most appropriate contract price adjustment method is the method at 22.404-12(c)(1) or (2); or....222-31, Davis-Bacon Act—Price Adjustment (Percentage Method), in solicitations and contracts if the...

Tension-time index, fatigue, and energetics in isolated rat diaphragm: a new experimental model.

PubMed

Klawitter, Paul F; Clanton, Thomas L

2004-01-01

The tension-time index (TTI) has been used to estimate mechanical load, energy utilization, blood flow, and susceptibility to fatigue in contracting muscle. The TTI can be defined, for a rhythmically contracting muscle, as the product of average force development divided by maximum tetanic force times duty cycle [contraction time / (contraction + relaxation time)]. In this study, the TTI concept was applied to isolated diaphragm via a method that allowed TTI to be clamped at a predetermined value. The hypothesis tested was that, at constant TTI, muscle energetics and the extent of fatigue would vary with stimulation frequency. Isolated diaphragm strips were stimulated at 25, 50, 75, or 100 Hz for 4 min, one per second. Duty cycle was continuously adjusted to maintain TTI at 0.07, which was near the highest TTI tolerated for 4 min, at 20-Hz stimulation. At the end of the fatigue run, muscles were either immediately frozen for determination ATP, creatine, and creatine phosphate concentrations (n = 6) or stimulated for evaluation of low- and high-frequency fatigue (n = 5). Results demonstrated no difference in the extent of fatigue or in the final ATP and creatine phosphate concentrations between groups. Large within-run increases in duty cycle were required at low stimulation frequencies, but only small increases were required at the highest frequencies. The results demonstrate that, at a constant TTI, similar fatigue properties predominate at all stimulation frequencies with no clear distinction between high- and low-frequency fatigue. The method of clamping TTI during fatigue may be useful for evaluating energetics and contractile function between treatment groups in isolated muscle when treatment influences baseline contractile characteristics.

Predictable and Adaptable Complex Real-Time Systems

DTIC Science & Technology

1993-09-30

Predictable and Adaptable Complex Real - Time Systems Grant or Contract Number: N00014-92-J-1048 Reporting Period: 1 Oct 91 - 30 Sep 93 1... Real - Time Systems Grant or Contract Number: N00014-92-J-1048 Reporting Period: 1 Oct 91 - 30 Sep 93 2. Summary of Technical Progress Our...cs.umass.edu Grant or Contract Title: Predictable and Adaptable Complex Real - Time Systems Grant or Contract Number: N00014-92-J-1048 Reporting Period: 1 Oct 91

Delivering radiology supplies just-in-time.

PubMed

Clinton, M

1999-01-01

The radiology department at Dartmouth Hitchcock Medical Center (DHMC) adopted a just-in-time (JIT) inventory management system in 1992, reducing the volume of its in-house inventory of radiology supplies from a value of $400,000 to $16,000, just enough for four to five days of activity. An asset manager, the only person authorized to order supplies, was given responsibility for maintaining the department's supply of fixed and consumable assets. The first step in implementing the new system was to identify the supplies needed, standardize them and determine how often deliveries would be made. The JIT implementation team developed a request for proposal (RFP) that incorporated the standardized list of supplies. Three radiology supply vendors were invited to respond to the RFP. The team later determined that only one vendor was capable of implementing the JIT program. A three-year contract was awarded to that vendor. As that three-year contract reached completion, DHMC offered the JIT program to its eight affiliate hospitals and four outpatient clinics. The team decided to re-bid the contract for the entire network, which collectively performed 700,000 radiology exams annually. The new RFP encompassed 90 percent of the network's consumable supplies and offered customized delivery for each facility. The team identified eight criteria necessary for the evaluation of each vendor response to the RFP, rather than use price as the only consideration. The company that won the three-year contract furnished 90 percent of the radiology supplies for the DHMC network, allowing even further savings by the network, particularly for the smaller facilities and clinics. The program is continually monitored, adjusted and enhanced in order to incorporate changing departmental needs.

7 CFR 4288.121 - Contract.

Code of Federal Regulations, 2014 CFR

2014-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General Provisions Enrollment Provisions § 4288.121 Contract. Advanced biofuel producers determined to be eligible to.... (a) Contract. The Agency will forward the contract to the advanced biofuel producer. The advanced...

Hilbert–Huang transform in detecting and analyzing the uterine contraction activities

PubMed Central

Aydın, Kemal; Demirer, Murat; Bayrak, Coşkun

2015-01-01

Objective The diagnosis of labor is currently one of the most difficult problems encountered by obstetrical healthcare providers. A major health problem is the increase in the rate of preterm delivery, which is responsible for 75% of all deaths in newborns. In addition, preterm delivery is associated with several cognitive and health problems in later life and enormous costs for the health system. A better understanding of myometrial activities could help to reduce preterm deliveries and the costs associated with prematurity in the following years. Therefore, the objective of this study was to determine whether using the Hilbert–Huang transform (HHT) to analyze the uterine contraction data would help us gain a better insight of the myometrial activities of the human uterus during pregnancy. Material and Methods Uterine magnetomyographic (MMG) signals were recorded from pregnant patients at gestational ages of 32–38 weeks. The study was approved by the Human Research Advisory Board of the University of Arkansas for Medical Sciences (UAMS) and performed after obtaining written consent from each patient. The recording of transabdominal MMG signals was conducted with the SQUID Array for Reproductive Assessment (SARA, VSM MedTech Inc; Coquitlam, BC, Canada) system, which has 151 primary magnetic sensors allocated approximately 3 cm apart over an area of 850 cm2. The arrangement of sensors is concave in nature and, in a similar lateral distance, spans the maternal abdomen longitudinally from the symphysis pubis to the uterine fundus. The recording times ranged from 12 to 28 min, and the sampling rate was 250 Hz. The data were down-sampled to 25 Hz to reduce the computational complexity and post-processed with a bandpass filter (0.05–1 Hz) because the uterine contraction activity is a band-limited process (0.05–1 Hz). The recordings of one intrauterine pressure catheter (IUPC) dataset and two mother-perceived contraction datasets were compared with the HHT results, and HHT’s potential was explored through the development of a module and a series of experiments. The local energy and the instantaneous frequency derived from the intrinsic mode functions (IMFs) through HHT provide a full energy-frequency-time distribution of the data. Our objective was to determine whether HHT for each channel can help identify and localize contractions in the uterus. Human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards described in an appropriate version of the 1975 Declaration of Helsinki, as revised in 2000. Results After comparing the IUPC and other mother-perceived contraction (STIM) datasets with HHT results, we were able to visually detect contraction locations in the HHT-processed uterine signals. For verification and validation purposes, when we further analyzed the delay time between two signals, the mechanical activity (i.e., IUPC) following the electrical activity (i.e., magnetic signal) was observed. In conclusion, our experimentations using the method introduced here revealed that there is a 75% correlation between the results obtained by HHT and IUPC data. Conclusion This study compared uterine contractions and changes in the intrauterine pressure with results obtained by HHT. In addition, using IUPC data as a validation guide, we showed that the HHT approach can be used for noise removal. There is a need for time-saving and non-subjective automatic contraction detection in the field of prenatal examination. PMID:26692768

48 CFR 1316.602 - Labor-hour contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Labor-hour contracts. 1316... AND CONTRACT TYPES TYPES OF CONTRACTS Time-and-Materials, Labor-Hour, and Letter Contracts 1316.602 Labor-hour contracts. ...

30 CFR 1206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

Code of Federal Regulations, 2011 CFR

2011-07-01

... under an arm's-length transportation contract? 1206.110 Section 1206.110 Mineral Resources OFFICE OF... VALUATION Federal Oil § 1206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length...

Towards a Fast Dynamic Model of the Human Circulatory System

DTIC Science & Technology

2011-10-06

heart chambers, and the local time-varying pressure is not prescribed anywhere. The effects of muscle contraction and relaxation on the circulatory...0.5 < S < 2) area during skeletal muscle contraction . Contraction only applied on the venous end of the vascular tree (1.25 < S < 2). For the... contraction , occurring during time (tam < t < tbm), and ∆Am is the maximum contraction amplitude. A visualization of the muscle contraction model is shown in

Effects of different duration isometric contractions on tendon elasticity in human quadriceps muscles

PubMed Central

Kubo, Keitaro; Kanehisa, Hiroaki; Fukunaga, Tetsuo

2001-01-01

The present study aimed to investigate the influence of isometric training protocols with long- and short-duration contractions on the elasticity of human tendon structures in vivo. The elasticity was assessed through in vivo determination of the elongation (L) of the tendons and aponeuroses using ultrasonography, while the subjects performed ramp isometric exercise up to maximum voluntary contraction (MVC).Eight young males completed 12 weeks (4 days per week) of a unilateral isometric training programme on knee extensors, which consisted of two different combinations of contraction and relaxation times at 70 % MVC: one leg was trained using a short-duration protocol (3 sets of 50 repetitions of contraction for 1 s and relaxation for 2 s), and the other leg was trained using a long-duration protocol (4 sets of a combination of contraction for 20 s and relaxation for 1 min). The training volume per session, expressed as the integrated torque, was the same for the two protocols.Both protocols resulted in a significant increase in MVC: 31.8 ± 17.2 % for the short-duration protocol and 33.9 ± 14.4 % for the long-duration protocol. Moreover, the training produced significant increases in the muscle volume of the constituents of the quadriceps femoris, with similar relative gains for the two protocols: 7.4 ± 3.9 % for the short-duration protocol and 7.6 ± 4.3 % for the long-duration protocol.The short-duration protocol produced no significant change in L values at any of the force production levels. For the long-duration protocol, however, the L values above 550 N were significantly shorter after training. Analysis revealed that the group × test time interaction effect on tendon stiffness was significant. Stiffness increased significantly for the long-duration protocol, but not for the short-duration protocol.The present study demonstrates a greater increase in stiffness of human tendon structures following isometric training using longer duration contractions compared to shorter contractions. This suggests that the changes in the elasticity of the tendon structures after resistance training may be affected by the duration of muscle contraction. PMID:11600697

Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions.

PubMed

McLoughlin, Thomas J; Mylona, Eleni; Hornberger, Troy A; Esser, Karyn A; Pizza, Francis X

2003-03-01

We determined the effect of muscle contractions resulting from high-frequency electrical stimulation (HFES) on inflammatory cells in rat tibialis anterior (TA), plantaris (Pln), and soleus (Sol) muscles at 6, 24, and 72 h post-HFES. A minimum of four and a maximum of seven rats were analyzed at each time point. HFES, applied to the sciatic nerve, caused the Sol and Pln to contract concentrically and the TA to contract eccentrically. Neutrophils were higher (P < 0.05) at 6 and 24 h after HFES in the Sol, Pln, and TA muscles relative to control muscles. ED1(+) macrophages in the Pln were elevated at 6 and 24 h after HFES and were also elevated in the Sol and TA after HFES relative to controls. ED2(+) macrophages in the Sol and TA were elevated at 24 and 72 h after HFES, respectively, and were also elevated in the Pln after HFES relative to controls. In contrast to the TA muscles, the Pln and Sol muscles showed no gross histological abnormalities. Collectively, these data indicate that both eccentric and concentric contractions can increase inflammatory cells in muscle, regardless of whether overt histological signs of injury are apparent.

Parasympathetic neural control of canine tracheal smooth muscle.

PubMed

Kobayashi, Ichiro; Kondo, Tetsuri; Hayama, Naoki; Tazaki, Gen

2004-12-01

The middle segment of the trachea is innervated by the recurrent laryngeal and pararecurrent nerves. This study determined the pathway that mediated descending commands to the tracheal smooth muscle. Animals used were seven paralyzed and tracheostomized dogs. Tracheal contraction induced either by apnea, mechanical stimulation of the tracheal bifurcation or hypercapnia was always composed of tonic and rhythmic components. The rhythmic contraction developed in synchrony with rhythmic bursts on phrenic nerve activity (PNA). The respiratory-related bursts were also observed on the recurrent laryngeal nerve activity (RNA) and pararecurrent nerve activity (ParaRNA). During apnea there was no tonic activity neither on RNA or PNA, whereas ParaRNA had both tonic and rhythmic activities. Bursts on RNA preceded to correspondent PNA-bursts by 90+/-13 ms. In contrast, ParaRNA-burst always developed later than PNA-burst and it started at almost the same time as that of tracheal rhythmic contraction. During mechanical stimulation of the trachea or CO2-loading, though RNA did not include tonic component, ParaRNA had tonic activity during tracheal tonic contraction. These findings suggested that rhythmic and tonic contractions of the trachea were mediated through the pararecurrent nerve but not through the recurrent laryngeal nerve.

78 FR 32405 - Request for Public Comment; 30-day Proposed Information Collecton: Indian Self-Determination and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

.... Data OMB Control Number: 1076-0136. Title: Indian Self-Determination and Education Assistance Contracts... Proposed Information Collecton: Indian Self-Determination and Education Assistance Contracts AGENCY: Indian... (OMB) a request for renewal for the collection of information titled, ``Indian Self-Determination and...

Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct

NASA Technical Reports Server (NTRS)

Gashev, Anatoliy A.; Davis, Michael J.; Zawieja, David C.; Delp, M. D. (Principal Investigator)

2002-01-01

There are only a few reports of the influence of imposed flow on an active lymph pump under conditions of controlled intraluminal pressure. Thus, the mechanisms are not clearly defined. Rat mesenteric lymphatics and thoracic ducts were isolated, cannulated and pressurized. Input and output pressures were adjusted to impose various flows. Lymphatic systolic and diastolic diameters were measured and used to determine contraction frequency and pump flow indices. Imposed flow inhibited the active lymph pump in both mesenteric lymphatics and in the thoracic duct. The active pump of the thoracic duct appeared more sensitive to flow than did the active pump of the mesenteric lymphatics. Imposed flow reduced the frequency and amplitude of the contractions and accordingly the active pump flow. Flow-induced inhibition of the active lymph pump followed two temporal patterns. The first pattern was a rapidly developing inhibition of contraction frequency. Upon imposition of flow, the contraction frequency immediately fell and then partially recovered over time during continued flow. This effect was dependent on the magnitude of imposed flow, but did not depend on the direction of flow. The effect also depended upon the rate of change in the direction of flow. The second pattern was a slowly developing reduction of the amplitude of the lymphatic contractions, which increased over time during continued flow. The inhibition of contraction amplitude was dependent on the direction of the imposed flow, but independent of the magnitude of flow. Nitric oxide was partly but not completely responsible for the influence of flow on the mesenteric lymph pump. Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by N (G)-monomethyl-L-arginine attenuated but did not completely abolish the effects of flow.

Postprandial gastric antral contractions in patients with gastro-oesophageal reflux disease: a scintigraphic study.

PubMed

Barbieri, C L A; Troncon, L E A; Herculano, J R L; Aprile, L R O; Moraes, E R; Secaf, M; Dantas, R O

2008-05-01

Disturbed gastric contractility has been found in manometric studies in patients with gastro-oesophageal reflux disease (GORD), but the pathophysiological role of this abnormality is unclear. We aimed at assessing postprandial gastric antral contractions and its relationships with gastric emptying and gastro-oesophageal reflux in GORD patients. Fasted GORD patients (n = 13) and healthy volunteers (n = 13) ingested a liquid meal labelled with 72 MBq of 99mTechnetium-phytate. Gastric images were acquired every 10 min for 2 h, for measuring gastric emptying half time. Dynamic antral scintigraphy (one frame per second), performed for 4 min at 30-min intervals, allowed estimation of both mean dominant frequency and amplitude of antral contractions. In GORD patients (n = 10), acidic reflux episodes occurring 2 h after the ingestion of the same test meal were determined by ambulatory 24-h oesophageal pH monitoring. Gastric emptying was similar in GORD patients and controls (median; range: 82 min; 58-126 vs 80 min; 44-122 min; P = 0.38). Frequency of antral contractions was also similar in both groups (3.1 cpm; 2.8-3.6 vs 3.2 cpm; 2.4-3.8 cpm; P = 0.15). In GORD patients, amplitude of antral contractions was significantly higher than in controls (32.7%; 17-44%vs 23.3%; 16-43%; P = 0.01), and correlated positively with gastric emptying time (R(s) = 0.58; P = 0.03) and inversely with the number of reflux episodes (R(s) = -0.68; P = 0.02). Increased amplitude of postprandial gastric antral contractions in GORD may comprise a compensatory mechanism against delayed gastric emptying and a defensive factor against acidic gastro-oesophageal reflux.

Exploring the market for third-party-owned residential photovoltaic systems: insights from lease and power-purchase agreement contract structures and costs in California

DOE PAGES

Davidson, Carolyn; Steinberg, Daniel; Margolis, Robert

2015-02-04

We report that over the past several years, third-party-ownership (TPO) structures for residential photovoltaic (PV) systems have become the predominant ownership model in the US residential market. Under a TPO contract, the PV system host typically makes payments to the third-party owner of the system. Anecdotal evidence suggests that the total TPO contract payments made by the customer can differ significantly from payments in which the system host directly purchases the system. Furthermore, payments can vary depending on TPO contract structure. To date, a paucity of data on TPO contracts has precluded studies evaluating trends in TPO contract cost. Thismore » study relies on a sample of 1113 contracts for residential PV systems installed in 2010–2012 under the California Solar Initiative to evaluate how the timing of payments under a TPO contract impacts the ultimate cost of the system to the customer. Furthermore, we evaluate how the total cost of TPO systems to customers has changed through time, and the degree to which contract costs have tracked trends in the installed costs of a PV system. We find that the structure of the contract and the timing of the payments have financial implications for the customer: (1) power-purchase contracts, on average, cost more than leases, (2) no-money-down contracts are more costly than prepaid contracts, assuming a customer's discount rate is lower than 17% and (3) contracts that include escalator clauses cost more, for both power-purchase agreements and leases, at most plausible discount rates. Additionally, all contract costs exhibit a wide range, and do not parallel trends in installed costs over time.« less

Exploring the market for third-party-owned residential photovoltaic systems: insights from lease and power-purchase agreement contract structures and costs in California

NASA Astrophysics Data System (ADS)

Davidson, Carolyn; Steinberg, Daniel; Margolis, Robert

2015-02-01

Over the past several years, third-party-ownership (TPO) structures for residential photovoltaic (PV) systems have become the predominant ownership model in the US residential market. Under a TPO contract, the PV system host typically makes payments to the third-party owner of the system. Anecdotal evidence suggests that the total TPO contract payments made by the customer can differ significantly from payments in which the system host directly purchases the system. Furthermore, payments can vary depending on TPO contract structure. To date, a paucity of data on TPO contracts has precluded studies evaluating trends in TPO contract cost. This study relies on a sample of 1113 contracts for residential PV systems installed in 2010-2012 under the California Solar Initiative to evaluate how the timing of payments under a TPO contract impacts the ultimate cost of the system to the customer. Furthermore, we evaluate how the total cost of TPO systems to customers has changed through time, and the degree to which contract costs have tracked trends in the installed costs of a PV system. We find that the structure of the contract and the timing of the payments have financial implications for the customer: (1) power-purchase contracts, on average, cost more than leases, (2) no-money-down contracts are more costly than prepaid contracts, assuming a customer’s discount rate is lower than 17% and (3) contracts that include escalator clauses cost more, for both power-purchase agreements and leases, at most plausible discount rates. In addition, all contract costs exhibit a wide range, and do not parallel trends in installed costs over time.

Exploring the market for third-party-owned residential photovoltaic systems: insights from lease and power-purchase agreement contract structures and costs in California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davidson, Carolyn; Steinberg, Daniel; Margolis, Robert

We report that over the past several years, third-party-ownership (TPO) structures for residential photovoltaic (PV) systems have become the predominant ownership model in the US residential market. Under a TPO contract, the PV system host typically makes payments to the third-party owner of the system. Anecdotal evidence suggests that the total TPO contract payments made by the customer can differ significantly from payments in which the system host directly purchases the system. Furthermore, payments can vary depending on TPO contract structure. To date, a paucity of data on TPO contracts has precluded studies evaluating trends in TPO contract cost. Thismore » study relies on a sample of 1113 contracts for residential PV systems installed in 2010–2012 under the California Solar Initiative to evaluate how the timing of payments under a TPO contract impacts the ultimate cost of the system to the customer. Furthermore, we evaluate how the total cost of TPO systems to customers has changed through time, and the degree to which contract costs have tracked trends in the installed costs of a PV system. We find that the structure of the contract and the timing of the payments have financial implications for the customer: (1) power-purchase contracts, on average, cost more than leases, (2) no-money-down contracts are more costly than prepaid contracts, assuming a customer's discount rate is lower than 17% and (3) contracts that include escalator clauses cost more, for both power-purchase agreements and leases, at most plausible discount rates. Additionally, all contract costs exhibit a wide range, and do not parallel trends in installed costs over time.« less

48 CFR 31.303 - Requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Requirements. 31.303... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Educational Institutions 31.303 Requirements. (a) Contracts that refer to this subpart 31.3 for determining allowable costs under contracts...

48 CFR 31.303 - Requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Requirements. 31.303... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Educational Institutions 31.303 Requirements. (a) Contracts that refer to this subpart 31.3 for determining allowable costs under contracts...

48 CFR 31.303 - Requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Requirements. 31.303... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Educational Institutions 31.303 Requirements. (a) Contracts that refer to this subpart 31.3 for determining allowable costs under contracts...

48 CFR 31.303 - Requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Requirements. 31.303... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Educational Institutions 31.303 Requirements. (a) Contracts that refer to this subpart 31.3 for determining allowable costs under contracts...

48 CFR 42.705-1 - Contracting officer determination procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... a multidivisional corporation under the cognizance of a corporate administrative contracting officer... organization. (2) Business units not under the cognizance of a corporate administrative contracting officer... accounting system capabilities. The contractor, contracting officer, and auditor must work together to make...

48 CFR 11.503 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Liquidated Damages—Supplies, Services, or Research and Development, in fixed-price solicitations and contracts for supplies, services, or research and development when the contracting officer determines that...—Construction, in solicitations and contracts for construction, other than cost-plus-fixed-fee, when the...

76 FR 44884 - Federal Acquisition Regulation; Payments Under Time-and-Materials and Labor-Hour Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... Acquisition Regulation; Payments Under Time-and-Materials and Labor-Hour Contracts AGENCY: Department of... Acquisition Regulation (FAR) to make necessary revisions to accommodate the authorization to use time-and... significant changes to the regulations for time-and- materials and labor-hour contracts: (1) FAR Case 2003-027...

48 CFR 42.705-2 - Auditor determination procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Auditor determination... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.705-2 Auditor determination procedure. (a) Applicability and responsibility. (1) The cognizant Government auditor shall...

48 CFR 42.705-2 - Auditor determination procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Auditor determination... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Indirect Cost Rates 42.705-2 Auditor determination procedure. (a) Applicability and responsibility. (1) The cognizant Government auditor shall...

48 CFR 47.304 - Determination of delivery terms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Determination of delivery terms. 47.304 Section 47.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.304 Determination of delivery...

Endocrinology of parturition

PubMed Central

Kota, Sunil K.; Gayatri, Kotni; Jammula, Sruti; Kota, Siva K.; Krishna, S. V. S.; Meher, Lalit K.; Modi, Kirtikumar D.

2013-01-01

The myometrium must remain relatively quiescent during pregnancy to accommodate growth and development of the feto-placental unit, and then must transform into a highly coordinated, strongly contracting organ at the time of labour for successful expulsion of the new born. The control of timing of labour is complex involving interactions between mother, fetus and the placenta. The timely onset of labour and delivery is an important determinant of perinatal outcome. Both preterm birth (delivery before 37 week of gestation) and post term pregnancy (pregnancy continuing beyond 42 weeks) are both associated with a significant increase in perinatal morbidity and mortality. There are multiple paracrine/autocrine events, fetal hormonal changes and overlapping maternal/fetal control mechanisms for the triggering of parturition in women. Our current article reviews the mechanisms for uterine distension and reduced contractions during pregnancy and the parturition cascade responsible for the timely and spontaneous onset of labour at term. It also discusses the mechanisms of preterm labour and post term pregnancy and the clinical implications thereof. PMID:23776853

48 CFR 49.206-1 - Submission of settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for... settlement proposals if they are determined under generally recognized accounting principles consistently...

48 CFR 915.404-4-71-6 - Fee base.

Code of Federal Regulations, 2014 CFR

2014-10-01

... in the Construction Contracts Schedule and Construction Management Contracts Schedule represents that... in the case of a construction or construction management contract: (1) Site preparation and utilities... fee base for the basic fee determination for a construction contract and construction management...

48 CFR 46.202-2 - Government reliance on inspection by contractor.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-2 Government... acquired at or below the simplified acquisition threshold conform to contract quality requirements before... the contractor's internal work processes. In making the determination, the contracting officer shall...

48 CFR 46.202-2 - Government reliance on inspection by contractor.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-2 Government... acquired at or below the simplified acquisition threshold conform to contract quality requirements before... the contractor's internal work processes. In making the determination, the contracting officer shall...

48 CFR 46.202-2 - Government reliance on inspection by contractor.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Quality Requirements 46.202-2 Government... acquired at or below the simplified acquisition threshold conform to contract quality requirements before... the contractor's internal work processes. In making the determination, the contracting officer shall...

7 CFR 1726.303 - Promulgation of new or revised contract forms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... change the existing identification of a listed contract form; for example, changing the issuance date of... 7 Agriculture 11 2011-01-01 2011-01-01 false Promulgation of new or revised contract forms. 1726... Standard Forms § 1726.303 Promulgation of new or revised contract forms. RUS may, from time to time...

21 CFR 14.15 - Committees working under a contract with FDA.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Committees working under a contract with FDA. 14... under a contract with FDA. (a) FDA may enter into contracts with independent scientific or technical... contract initially executed with FDA after July 1, 1975, but which is determined not to be an advisory...

21 CFR 14.15 - Committees working under a contract with FDA.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Committees working under a contract with FDA. 14... under a contract with FDA. (a) FDA may enter into contracts with independent scientific or technical... contract initially executed with FDA after July 1, 1975, but which is determined not to be an advisory...

21 CFR 14.15 - Committees working under a contract with FDA.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Committees working under a contract with FDA. 14... under a contract with FDA. (a) FDA may enter into contracts with independent scientific or technical... contract initially executed with FDA after July 1, 1975, but which is determined not to be an advisory...

21 CFR 14.15 - Committees working under a contract with FDA.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Committees working under a contract with FDA. 14... under a contract with FDA. (a) FDA may enter into contracts with independent scientific or technical... contract initially executed with FDA after July 1, 1975, but which is determined not to be an advisory...

21 CFR 14.15 - Committees working under a contract with FDA.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Committees working under a contract with FDA. 14... under a contract with FDA. (a) FDA may enter into contracts with independent scientific or technical... contract initially executed with FDA after July 1, 1975, but which is determined not to be an advisory...

7 CFR 46.43 - Terms construed.

Code of Federal Regulations, 2013 CFR

2013-01-01

... be loaded and shipped on a boat scheduled to leave before midnight of the date specified. When used... to determine if the produce shipped complied with the terms of the contract at time of shipment... f.o.b. shipping point, the buyer shall be deemed to have assumed only the lowest all-rail freight...

41 CFR 128-48.150 - Determination of type of property.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Determination of type of property. 128-48.150 Section 128-48.150 Public Contracts and Property Management Federal Property... § 128-48.150 Determination of type of property. If a bureau is unable to determine whether the personal...

41 CFR 128-48.150 - Determination of type of property.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Determination of type of property. 128-48.150 Section 128-48.150 Public Contracts and Property Management Federal Property... § 128-48.150 Determination of type of property. If a bureau is unable to determine whether the personal...

41 CFR 128-48.150 - Determination of type of property.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Determination of type of property. 128-48.150 Section 128-48.150 Public Contracts and Property Management Federal Property... § 128-48.150 Determination of type of property. If a bureau is unable to determine whether the personal...

41 CFR 128-48.150 - Determination of type of property.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Determination of type of property. 128-48.150 Section 128-48.150 Public Contracts and Property Management Federal Property... § 128-48.150 Determination of type of property. If a bureau is unable to determine whether the personal...

41 CFR 128-48.150 - Determination of type of property.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Determination of type of property. 128-48.150 Section 128-48.150 Public Contracts and Property Management Federal Property... § 128-48.150 Determination of type of property. If a bureau is unable to determine whether the personal...

25 CFR 900.191 - Are employees of self-determination contractors providing health services under the self...

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 2 2014-04-01 2014-04-01 false Are employees of self-determination contractors providing health services under the self-determination contract protected by FTCA? 900.191 Section 900.191 Indians... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Federal Tort...

25 CFR 900.191 - Are employees of self-determination contractors providing health services under the self...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false Are employees of self-determination contractors providing health services under the self-determination contract protected by FTCA? 900.191 Section 900.191 Indians... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Federal Tort...

25 CFR 900.191 - Are employees of self-determination contractors providing health services under the self...

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 2 2012-04-01 2012-04-01 false Are employees of self-determination contractors providing health services under the self-determination contract protected by FTCA? 900.191 Section 900.191 Indians... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Federal Tort...

25 CFR 900.191 - Are employees of self-determination contractors providing health services under the self...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 2 2011-04-01 2011-04-01 false Are employees of self-determination contractors providing health services under the self-determination contract protected by FTCA? 900.191 Section 900.191 Indians... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Federal Tort...

25 CFR 900.191 - Are employees of self-determination contractors providing health services under the self...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false Are employees of self-determination contractors providing health services under the self-determination contract protected by FTCA? 900.191 Section 900.191 Indians... HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Federal Tort...

48 CFR 915.404-4-72 - Special considerations for cost-plus-award-fee contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... management and operating contracts or other contracts as determined by the Senior Procurement Executive, including those using the Construction, Construction Management, or Special Equipment Purchases/Subcontract... for construction and construction management contracts). However, the base amount should not normally...

48 CFR 915.404-4-72 - Special considerations for cost-plus-award-fee contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... management and operating contracts or other contracts as determined by the Senior Procurement Executive, including those using the Construction, Construction Management, or Special Equipment Purchases/Subcontract... for construction and construction management contracts). However, the base amount should not normally...

48 CFR 915.404-4-72 - Special considerations for cost-plus-award-fee contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... management and operating contracts or other contracts as determined by the Senior Procurement Executive, including those using the Construction, Construction Management, or Special Equipment Purchases/Subcontract... for construction and construction management contracts). However, the base amount should not normally...

48 CFR 915.404-4-72 - Special considerations for cost-plus-award-fee contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... management and operating contracts or other contracts as determined by the Senior Procurement Executive, including those using the Construction, Construction Management, or Special Equipment Purchases/Subcontract... for construction and construction management contracts). However, the base amount should not normally...

48 CFR 342.7003-2 - Procedures to be followed when withholding payments.

Code of Federal Regulations, 2013 CFR

2013-10-01

... when withholding payments. 342.7003-2 Section 342.7003-2 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Monitoring 342.7003-2... deliver required work or services. When making the determination to withhold contract payments in...

48 CFR 342.7003-2 - Procedures to be followed when withholding payments.

Code of Federal Regulations, 2012 CFR

2012-10-01

... when withholding payments. 342.7003-2 Section 342.7003-2 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Monitoring 342.7003-2... deliver required work or services. When making the determination to withhold contract payments in...

48 CFR 342.7003-2 - Procedures to be followed when withholding payments.

Code of Federal Regulations, 2011 CFR

2011-10-01

... when withholding payments. 342.7003-2 Section 342.7003-2 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Monitoring 342.7003-2... deliver required work or services. When making the determination to withhold contract payments in...

48 CFR 342.7003-2 - Procedures to be followed when withholding payments.

Code of Federal Regulations, 2014 CFR

2014-10-01

... when withholding payments. 342.7003-2 Section 342.7003-2 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Monitoring 342.7003-2... deliver required work or services. When making the determination to withhold contract payments in...

10 CFR 603.1000 - Contracting officer's responsibilities at time of award.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Contracting officer's responsibilities at time of award. 603.1000 Section 603.1000 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Executing the Award § 603.1000 Contracting officer's responsibilities at time of award...

48 CFR 622.404-11 - Wage determination appeals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Wage determination appeals. 622.404-11 Section 622.404-11 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC... Construction 622.404-11 Wage determination appeals. The cognizant contracting activity is the contracting...

Polymerization contraction stress in light-cured compomer restorative materials.

PubMed

Chen, H Y; Manhart, J; Kunzelmann, K-H; Hickel, R

2003-11-01

The magnitude and kinetics of polymerization contraction stress build-up may be potential predictors of bond failure of adhesive restorations. The present study determined these properties of seven commercial compomers (Dyract, Dyract AP, F2000 Rasant, Hytac, Compoglass F, Luxat, Glasiosite). Polymerization shrinkage was generated by 40 s light curing the test materials (800 mW/cm2). The contraction force induced was recorded for 300 s at room temperature (23-24 degrees C) by means of a Stress-Strain-Analyzer (C factor=0.33). Maximum contraction stress (MPa), coefficient of near linear fit of contraction force/time (gradient) and relative force rate (%/s) of each material were compared with that of two hybrid composites (Tetric Ceram, Prodigy). The statistical analysis was conducted by ANOVA (alpha=0.05) and post hoc Tukey's test. No statistically significant differences in the maximum stress between Glasiosite (2.27+/-0.06 MPa), Hytac (2.31+/-0.07 MPa) and Tetric Ceram (2.21+/-0.11 MPa), and between Compoglass F (2.60+/-0.18 MPa) and Prodigy (2.70+/-0.06 MPa) were found. The contraction stress of F2000 Rasant (3.41+/-0.09 MPa) and Luxat (3.33+/-0.08 MPa) were significantly highest, whilst Dyract exhibited the significantly lowest shrinkage stress (1.27+/-0.08 MPa) among the tested materials. High contraction stress, early start of stress build-up and rapid contraction force development may lead to failure of bond to tooth structure. This study suggested that the contraction stress and kinetic behavior of compomers are generally similar to those of hybrid composites in a dry condition. Dyract might be superior in maintaining the bond with cavity walls compared to conventional hybrid composites in view of its low shrinkage stress.

Arteriolar vasomotor control and contractile performance during fatiguing tetanic contractions in rat skeletal muscle: role of sympathetic system.

PubMed

Inagaki, Tadakatsu; Sonobe, Takashi; Poole, David C; Kano, Yutaka

2010-01-01

Using a fatiguing stimulation protocol designed specifically to enhance sympathetically-mediated vasoconstrictor tone, we explored the temporal profile of the evoked vasoconstrictor response, evaluated the presence of sympatholysis, and assessed the role of alpha1-adrenergic receptor-mediated vasoconstriction on muscle performance. Spinotrapezius muscles of Wistar rats were exteriorized and stimulated tetanically (100 Hz, 4-7 V, stimulus duration 700 ms) every 3 s for 2.5 min under control and prazosin (1 muM) superfused conditions. The extent and time course of diameter changes in arterioles (2 A) and venules (2 V) were determined after each of 10 discrete sets of muscle stimulation at 5-min intervals. A significant decrease of luminal diameter was observed in arterioles after tetanic contractions at 8-10 sets (8 sets: -34.4%, 9 sets: -39.4%, 10 sets: -38.6% vs pre-contraction at each set, p < 0.01). Prazosin significantly reduced but did not abolish the contraction-induced vasoconstriction. In both conditions, there was no reduction of venules diameter observed. Tetanic contractions force at the final 10th set was significantly decreased to 29.3 +/- 11.9% from pre-fatigue conditions, while tetanic contractions with prazosin force production was maintained at 70.4 +/- 14.2% at the 10th set. We conclude that in sequential bouts of contractions there was a progressively greater degree of arteriolar (but not venular) vasoconstriction which was attenuated substantially by prazosin.

"No-hire" clauses in healthcare sector contracts: their use and enforceability.

PubMed

Basanta, W Eugene

2006-01-01

In today's healthcare industry, many hospitals utilize outside agencies for both business and clinical functions. This Article acknowledges the prevalence of outsourcing contract labor in the healthcare arena and focuses on the restrictive provisions included in these employment contracts, particularly "no-hire" clauses. No-hire clauses are often included in contracts between healthcare providers and professional groups that provide clinical service employees to the provider, such as a medical practice group providing physicians to a hospital or an agency providing nurses to a nursing home. These clauses usually provide that the healthcare provider may not directly hire an employee provided by the professional group, nor may it contract with another professional group that later hires the employee. The purpose of a no-hire clause is two-fold: to protect the professional group's investment of time and moneyfor recruiting, training, and establishing the employee's clinical practice, and to give the professional group leverage to retain its employees. While noncompete clauses in employment contracts have traditionally been the subject of litigation, no-hire clauses raise distinct legal issues. Case law provides conflicting views as to the enforceability of these provisions. Some courts find no-hire clauses to be per se illegal restrictions on trade, while others will permit them when they are reasonable within a specific context. The author proposes that a multifactor test be applied on a case-by-case basis to determine the reasonableness of the no-hire provision in a given employment contract and suggests drafting improvements to facilitate enforcement.

Final Report on the Audit of the Administration of the Contract Closeout Process at the Defense Contract Management Region, Dallas

DTIC Science & Technology

1990-09-18

This is our final report on the Audit of the Administration of the Contract Closeout Process at the Defense Contract Management Region, Dallas (DCMR... audit was made from January to October 1989. The objectives of the audit were to determine the timeliness of the contract closeout process, the validity...As part of the audit , we also evaluated internal controls over the contract closeout process. As of December 31, 1988, the Contract Administration

Length Contraction Should not be Independent of Time

NASA Astrophysics Data System (ADS)

Smarandache, Florentin

2013-10-01

In Special Theory of Relativity it looks that the length contraction along the direction of the motion is independent of time, i.e. if a rocket flies one second, or the rocket flies one year the rocket's along-the-motion length contraction is the same, since the contraction factor C (v) =√{ 1 -v2/c2 } depends on the rocket's relativistic speed (v) and on the light speed in vacuum (c) only. We find this as unrealistic, incomplete. It is logical that flying more and more it should increase the length contraction. What about the cosmic bodies that continuously travel, do they contract only once or are they continuously contracting?

17 CFR 31.25 - Bid and ask prices; carrying charges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... must use the same bid price at any particular point in time to purchase a leverage contract from a... at any particular point in time to sell a leverage contract to a leverage customer (initiation of a... balance of the contract, which is the total initial value of the contract, using the ask price when the...

48 CFR 22.404-1 - Types of wage determinations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... in the “Archived DB WD” database on WDOL for information purposes only. Contracting officers may not use an archived wage determination in a contract action without obtaining prior approval of the...

7 CFR 634.26 - Contract modifications.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.26... thereof, or to accomplish equitable treatment with respect to other conservation, land-use, or water... water-quality plan. A contract may be modified only if it is determined that such modifications are...

7 CFR 634.26 - Contract modifications.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.26... thereof, or to accomplish equitable treatment with respect to other conservation, land-use, or water... water-quality plan. A contract may be modified only if it is determined that such modifications are...

7 CFR 634.26 - Contract modifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.26... thereof, or to accomplish equitable treatment with respect to other conservation, land-use, or water... water-quality plan. A contract may be modified only if it is determined that such modifications are...

7 CFR 634.26 - Contract modifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.26... thereof, or to accomplish equitable treatment with respect to other conservation, land-use, or water... water-quality plan. A contract may be modified only if it is determined that such modifications are...

41 CFR 50-203.20 - Examination of witnesses.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Examination of witnesses. 50-203.20 Section 50-203.20 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations...

41 CFR 50-203.20 - Examination of witnesses.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Examination of witnesses. 50-203.20 Section 50-203.20 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations...

41 CFR 50-203.21 - Decisions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Decisions. 50-203.21 Section 50-203.21 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations Under the Walsh...

41 CFR 50-203.20 - Examination of witnesses.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Examination of witnesses. 50-203.20 Section 50-203.20 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations...

29 CFR 4.163 - Section 4(c) of the Act.

Code of Federal Regulations, 2013 CFR

2013-07-01

... their support contracts. Thus, specific contract requirements from one contract may be broken out and... substantially the same job classifications, the predecessor contract which covers the greater portion of the... bargaining agreement. However, failure to include in the wage determination any job classification, wage rate...

29 CFR 4.163 - Section 4(c) of the Act.

Code of Federal Regulations, 2012 CFR

2012-07-01

... their support contracts. Thus, specific contract requirements from one contract may be broken out and... substantially the same job classifications, the predecessor contract which covers the greater portion of the... bargaining agreement. However, failure to include in the wage determination any job classification, wage rate...

29 CFR 4.163 - Section 4(c) of the Act.

Code of Federal Regulations, 2014 CFR

2014-07-01

... their support contracts. Thus, specific contract requirements from one contract may be broken out and... substantially the same job classifications, the predecessor contract which covers the greater portion of the... bargaining agreement. However, failure to include in the wage determination any job classification, wage rate...

29 CFR 4.163 - Section 4(c) of the Act.

Code of Federal Regulations, 2011 CFR

2011-07-01

... their support contracts. Thus, specific contract requirements from one contract may be broken out and... substantially the same job classifications, the predecessor contract which covers the greater portion of the... bargaining agreement. However, failure to include in the wage determination any job classification, wage rate...

41 CFR 50-203.18 - Evidence.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Evidence. 50-203.18 Section 50-203.18 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations Under the Walsh...

41 CFR 50-203.20 - Examination of witnesses.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Examination of witnesses. 50-203.20 Section 50-203.20 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations...

48 CFR 52.203-10 - Price or Fee Adjustment for Illegal or Improper Activity.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contract and the total cost and fee under a cost-type contract by the amount of profit or fee determined as... Regulation. (b) The price or fee reduction referred to in paragraph (a) of this clause shall be— (1) For cost...-incentive contracts, the Government may— (i) Reduce the contract target price and contract target profit...

Marine Corps Installations National Capital RegionRegional Contracting Office Generally Implemented Recommendations

DTIC Science & Technology

2016-07-29

Corps Installations National Capital Region–Regional Contracting Office Generally Implemented Recommendations J U LY 2 9 , 2 0 1 6 Report No...Installations National Capital Region–Regional Contracting Office Generally Implemented Recommendations Objective We determined whether the Marine...Corps Regional Contracting Office–National Capital Region implemented the recommendations in Report No. DODIG-2015-095, “Small Business Contracting

Stretch-induced contraction in pulmonary arteries.

PubMed

Kulik, T J; Evans, J N; Gamble, W J

1988-12-01

Stretch stimulates contraction of systemic blood vessels, but the response has not been described in pulmonary vessels. To determine whether pulmonary arteries contract when stretched, isolated cylindrical segments of pulmonary arteries were suspended between two parallel wires, stretched, and the active force was generated in response to stretch measured. Eighty-nine percent of segments from small (in situ diameter less than 1,000 microns) feline pulmonary arteries contracted when stretched, and in 65% of these the magnitude of stretch was related to the magnitude of contraction. Large (in situ diameter greater than or equal to 1,000 microns) feline pulmonary arteries did not contract with stretch. Multiple, rapidly repeated stretches resulted in a diminution of active force development. Stretch-induced contraction required external Ca2+ and was abolished by diltiazem (10 microns), but it was not affected by phenoxybenzamine, phentolamine, diethylcarbamazine, or mechanical removal of endothelium. Indomethacin blunted but did not abolish stretch-induced contraction, an effect that may have been nonspecific. This study suggests that stretch can act, probably directly, on smooth muscle in small feline pulmonary arteries to elicit contraction and that it may be a determinant of pulmonary vascular tone. In addition, feline pulmonary arteries are suitable for the in vitro study of stretch-induced contraction.

48 CFR 22.404-8 - Notification of improper wage determination before award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS... determination is withdrawn by the Administrative Review Board. (b) In sealed bidding, the contracting officer... determination for the primary site of the work reaches the contracting officer before bid opening, the...

Ex vivo pharmacology of surgical samples of the uterosacral ligament. Part I: Effects of carbachol and oxytocin on smooth muscle.

PubMed

Drews, Ulrich; Renz, Matthias; Busch, Christian; Reisenauer, Christl

2012-11-01

In a previous study we observed impaired smooth muscle in the uterosacral ligament (USL) of patients with pelvic organ prolapse. The aims of the study were to describe the method of the novel microperfusion system and to determine normal function and pharmacology of smooth muscle in the USL. Samples from the USL were obtained during hysterectomy for benign reasons. Small stretches of connective tissue were mounted in a perfusion chamber under the stereomicroscope. Isotonic contractions of smooth muscle were monitored by digital time-lapse video and quantified by image processing. Constant perfusion with carbachol elicited tonic and pulse stimulation with carbachol and oxytocin rhythmic contractions of smooth muscle in the ground reticulum. Under constant perfusion with relaxin the tonic contraction after carbachol was abolished. With the novel microperfusion system, isotonic contractions of smooth muscle in the USL can be recorded and quantified in the tissue microenvironment on the microscopic level. The USL smooth muscle is cholinergic, stimulated by oxytocin and modulated by relaxin. Copyright © 2012 Wiley Periodicals, Inc.

A Contract That Manages Itself: The Time Has Arrived

DTIC Science & Technology

2015-02-01

technology inspires contracting. The Smart Contract The paradigm of a contract as a static document is about to change. The days of a contract being read...efficiency is of paramount importance in order for an organization to perform its mission. The Smart Contract as an Object In discussions about...the contract object ( smart contract ) exists, the contract will be able to interact with other objects. That will enable the contract to know how

Contraction velocity influence the magnitude and etiology of neuromuscular fatigue during repeated maximal contractions.

PubMed

Morel, B; Clémençon, M; Rota, S; Millet, G Y; Bishop, D J; Brosseau, O; Rouffet, D M; Hautier, C A

2015-10-01

This study aimed to compare the magnitude and etiology of neuromuscular fatigue during maximal repeated contractions performed in two contraction modes (concentric vs isometric) and at two contraction velocities (30/s vs 240°/s). Eleven lower limb-trained males performed 20 sets of maximal contractions at three different angular velocities: 0°/s (KE0), 30/s (KE30), and 240°/s (KE240). Cumulated work, number of contraction, duty cycle, and contraction time were controlled. Torque, superimposed and resting twitches, as well as gas exchange, were analyzed. Increasing contraction velocity was associated with greater maximal voluntary torque loss (KE0: -9.8 ± 3.9%; KE30: -16.4 ± 8.5%; KE240: -32.6 ± 6.3%; P < 0.05). Interestingly, the torque decrease was similar for a given cumulated work. Compared with KE0, KE240 generated a greater evoked torque loss (Db100: -24.3 ± 5.3% vs -5.9 ± 6.9%; P < 0.001), a higher O2 consumption (23.7 ± 6.4 mL/min/kg vs 15.7 ± 3.8 mL/min/kg; P < 0.001), but a lower voluntary activation (VA) loss (-4.3 ± 1.6% vs -11.2 ± 4.9%; P < 0.001). The neuromuscular perturbations were intermediate for KE30 (Db100: -10.0 ± 6.8%; VA: -7.2 ± 2.8%). Although the amount of mechanical work cumulated strongly determined the magnitude of torque decrease, the contraction velocity and mode influenced the origin of the neuromuscular fatigue. The metabolic stress and peripheral fatigue increased but reduction of VA is attenuated when the contraction velocity increased from 0°/s to 240°/s. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Timbal muscle physiology in the endothermic cicada Tibicen winnemanna (Homoptera: Cicadidae).

PubMed

Sanborn, A F

2001-08-01

The operative muscle temperature and contraction kinetics are described for the endothermic cicada Tibicen winnemanna (Davis). Measurements of timbal muscle temperature in the field demonstrate that timbal muscle temperature is elevated above ambient temperature during activity. Timbal muscle temperature increases as the acoustic output progresses from a 'warm-up' buzz (27.9-29.7 degrees C) to full song production (36.3-39.5 degrees C). Mean muscle-ambient temperature difference increases from 5.8 degrees C in buzzing animals to 13.1 degrees C in animals producing a full calling song. Twitch rise time and onset to 50% relaxation time decrease while tension production increases with increasing temperature to 40 degrees C. Mean force production at 20 degrees C was determined to be 0.22+/-0.06 N/cm(2). The characteristics of T. winnemanna muscle are similar to those reported in other cicada species. Analysis of the songs produced by animals with one timbal destroyed and the sounds produced by mechanical manipulation suggest that the timbals alternately contract and relax in the sequence IN(1)-IN(2)-OUT(1)-OUT(2). Measurements of the inferred period of muscle contraction from song recordings and the contraction kinetics of isolated timbal muscles measured in the laboratory show that the temperature of the timbal muscle must be elevated in order for the cicada to be able to produce the calling song.

Time to Maximal Voluntary Isometric Contraction (MVC) for Five Different Muscle Groups in College Adults.

ERIC Educational Resources Information Center

Morris, A. F.; And Others

1983-01-01

College men and women were studied to ascertain the force-time components of a rapid voluntary muscle contraction for five muscle groups. Researchers found that the time required for full contraction differs: (1) in men and women; and (2) among the five muscle groups. (Authors/PP)

48 CFR 15.402 - Pricing policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... determining the type of data required: (i) No additional data from the offeror, if the price is based on... reasonable price. (3) Obtain the type and quantity of data necessary to establish a fair and reasonable price... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 15.402 Pricing policy. Contracting...

48 CFR 15.402 - Pricing policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... determining the type of data required: (i) No additional data from the offeror, if the price is based on... reasonable price. (3) Obtain the type and quantity of data necessary to establish a fair and reasonable price... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 15.402 Pricing policy. Contracting...

48 CFR 15.402 - Pricing policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... determining the type of data required: (i) No additional data from the offeror, if the price is based on... reasonable price. (3) Obtain the type and quantity of data necessary to establish a fair and reasonable price... AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 15.402 Pricing policy. Contracting...

41 CFR 50-201.201 - Breach of stipulations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Breach of stipulations... Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 201-GENERAL REGULATIONS § 50-201.201 Breach of... determination of a breach of stipulations is made, the Secretary of Labor will furnish to the contracting agency...

25 CFR 273.61 - Contract revision or amendment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Contract revision or amendment. 273.61 Section 273.61 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.62 - Cancelling a contract for cause.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Cancelling a contract for cause. 273.62 Section 273.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.71 - Contract appeal.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Contract appeal. 273.71 Section 273.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Appeals § 273.71 Contract appeal. A contractor may appeal an...

25 CFR 273.71 - Contract appeal.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Contract appeal. 273.71 Section 273.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Appeals § 273.71 Contract appeal. A contractor may appeal an...

25 CFR 273.62 - Cancelling a contract for cause.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Cancelling a contract for cause. 273.62 Section 273.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.61 - Contract revision or amendment.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Contract revision or amendment. 273.61 Section 273.61 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.61 - Contract revision or amendment.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Contract revision or amendment. 273.61 Section 273.61 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.62 - Cancelling a contract for cause.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Cancelling a contract for cause. 273.62 Section 273.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.71 - Contract appeal.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true Contract appeal. 273.71 Section 273.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Appeals § 273.71 Contract appeal. A contractor may appeal an...

25 CFR 273.71 - Contract appeal.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Contract appeal. 273.71 Section 273.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Appeals § 273.71 Contract appeal. A contractor may appeal an...

25 CFR 273.61 - Contract revision or amendment.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Contract revision or amendment. 273.61 Section 273.61 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.62 - Cancelling a contract for cause.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Cancelling a contract for cause. 273.62 Section 273.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.62 - Cancelling a contract for cause.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false Cancelling a contract for cause. 273.62 Section 273.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

25 CFR 273.71 - Contract appeal.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false Contract appeal. 273.71 Section 273.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Appeals § 273.71 Contract appeal. A contractor may appeal an...

25 CFR 273.61 - Contract revision or amendment.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Contract revision or amendment. 273.61 Section 273.61 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT PROGRAM EDUCATION CONTRACTS UNDER JOHNSON-O'MALLEY ACT Contract Revision or Cancellation § 273...

13 CFR 305.11 - Contract awards; early construction start.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Contract awards; early construction start. 305.11 Section 305.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION... § 305.11 Contract awards; early construction start. EDA must determine that the award of all contracts...

7 CFR 634.25 - Contracting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... agrees to apply his or her water-quality plan. Any person who controls, or shares control, of the farm... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Participant RCWP Contracts § 634.25 Contracting... of the farm, ranch, or other land. The administering agency is to determine the acceptability of the...

13 CFR 305.11 - Contract awards; early construction start.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Contract awards; early construction start. 305.11 Section 305.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION... § 305.11 Contract awards; early construction start. EDA must determine that the award of all contracts...

48 CFR 5145.302-3 - Other contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Other contracts. 5145.302... REGULATIONS GOVERNMENT PROPERTY 5145.302-3 Other contracts. (S-90)(1) When it is determined that contractor... installation support services contracts, is in the best interest of the Government, the Government facilities...

41 CFR 50-202.1 - Application and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Application and scope. 50-202.1 Section 50-202.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 202-MINIMUM WAGE DETERMINATIONS Application and Scope § 50...

41 CFR 50-202.1 - Application and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Application and scope. 50-202.1 Section 50-202.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 202-MINIMUM WAGE DETERMINATIONS Application and Scope § 50...

41 CFR 50-202.1 - Application and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Application and scope. 50-202.1 Section 50-202.1 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 202-MINIMUM WAGE DETERMINATIONS Application and Scope § 50...

41 CFR 50-203.19 - Subpoenas and witness fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Subpoenas and witness fees. 50-203.19 Section 50-203.19 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 203-RULES OF PRACTICE Minimum Wage Determinations...

Timing of cortical excitability changes during the reaction time of movements superimposed on tonic motor activity.

PubMed

Schneider, Cyril; Lavoie, Brigitte A; Barbeau, Hugues; Capaday, Charles

2004-12-01

Seated subjects were instructed to react to an auditory cue by simultaneously contracting the tibialis anterior (TA) muscle of each ankle isometrically. Focal transcranial magnetic stimulation of the leg area of the motor cortex (MCx) was used to determine the time course of changes in motor-evoked potential amplitude (MEP) during the reaction time (RT). In one condition the voluntary contraction was superimposed on tonic EMG activity maintained at 10% of maximal voluntary contraction. In the other condition the voluntary contraction was made starting from rest. MEPs in the TA contralateral to the stimulation coil were evoked at various times during the RT in each condition. These were compared to the control MEPs evoked during tonic voluntary activity or with the subject at rest. The RT was measured trial by trial from the EMG activity of the TA ipsilateral to the magnetic stimulus, taking into account the nearly constant time difference between the two sides. The MEPs became far greater than control MEPs during the RT (mean = 332%, SD = 44 %, of control MEPs, P < 0.001) without any measurable change in the background level of EMG activity. The onset of this facilitation occurred on average 12.80 ms (SD = 7.55 ms) before the RT. There was no difference in the onset of facilitation between the two conditions. Because MEPs were facilitated without a change in the background EMG activity, it is concluded that this facilitation is specifically due to an increase of MCx excitability just before voluntary muscle activation. This conclusion is further reinforced by the observation that MEPs evoked by near-threshold anodal stimuli to the MCx were not facilitated during the RT, in contrast to those evoked by near-threshold transcranial magnetic stimulation. However, several observations in the present and previous studies indicate that MEP amplitude may be more sensitive to alpha-motoneuron activity than to motor cortical neuron activity, an idea that has important methodological implications.

An Effective Technique for Enhancing an Intrauterine Catheter Fetal Electrocardiogram

NASA Astrophysics Data System (ADS)

Horner, Steven L.; Holls, William M.

2003-12-01

Physician can obtain fetal heart rate, electrophysiological information, and uterine contraction activity for determining fetal status from an intrauterine catheters electrocardiogram with the maternal electrocardiogram canceled. In addition, the intrauterine catheter would allow physicians to acquire fetal status with one non-invasive to the fetus biosensor as compared to invasive to the fetus scalp electrode and intrauterine pressure catheter used currently. A real-time maternal electrocardiogram cancellation technique of the intrauterine catheters electrocardiogram will be discussed along with an analysis for the methods effectiveness with synthesized and clinical data. The positive results from an original detailed subjective and objective analysis of synthesized and clinical data clearly indicate that the maternal electrocardiogram cancellation method was found to be effective. The resulting intrauterine catheters electrocardiogram from effectively canceling the maternal electrocardiogram could be used for determining fetal heart rate, fetal electrocardiogram electrophysiological information, and uterine contraction activity.

The effect of different acute muscle contraction regimens on the expression of muscle proteolytic signaling proteins and genes.

PubMed

Ato, Satoru; Makanae, Yuhei; Kido, Kohei; Sase, Kohei; Yoshii, Naomi; Fujita, Satoshi

2017-08-01

Previous studies have reported that different modes of muscle contraction (i.e., eccentric or concentric contraction) with similar contraction times can affect muscle proteolytic responses. However, the effect of different contraction modes on muscle proteolytic response under the same force-time integral (FTI: contraction force × time) has not been investigated. The purpose of this study was to investigate the effect of different contraction modes, with the same FTI, on acute proteolytic signaling responses. Eleven-week-old male Sprague-Dawley rats were randomly assigned to eccentric (EC), concentric (CC), or isometric contraction (IC) groups. Different modes of muscle contraction were performed on the right gastrocnemius muscle using electrical stimulation, with the left muscle acting as a control. In order to apply an equivalent FTI, the number of stimulation sets was modified between the groups. Muscle samples were taken immediately and three hours after exercise. Phosphorylation of FoxO3a at Ser253 was significantly increased immediately after exercise compared to controls irrespective of contraction mode. The mRNA levels of the ubiquitin ligases, MuRF1, and MAFbx mRNA were unchanged by contraction mode or time. Phosphorylation of ULK1 at Ser317 (positive regulatory site) and Ser757 (negative regulatory site) was significantly increased compared to controls, immediately or 3 h after exercise, in all contraction modes. The autophagy markers (LC3B-II/I ratio and p62 expression) were unchanged, regardless of contraction mode. These data suggest that differences in contraction mode during resistance exercise with a constant FTI, are not factors in regulating proteolytic signaling in the early phase of skeletal muscle contraction. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

25 CFR 900.246 - What does reassumption mean?

Code of Federal Regulations, 2011 CFR

2011-04-01

... HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT..., in whole or in part, of a contract and assuming or resuming control or operation of the contracted...

48 CFR 22.404-6 - Modifications of wage determinations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... solicitation, the contracting officer shall monitor the WDOL website to determine whether the applicable wage determination has been revised. Revisions published on the WDOL website or otherwise communicated to the... included in the resulting contract. Monitoring can be accomplished by use of the WDOL website's “Alert...

48 CFR 22.404-6 - Modifications of wage determinations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... solicitation, the contracting officer shall monitor the WDOL website to determine whether the applicable wage determination has been revised. Revisions published on the WDOL website or otherwise communicated to the... included in the resulting contract. Monitoring can be accomplished by use of the WDOL website's “Alert...

48 CFR 22.404-6 - Modifications of wage determinations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... solicitation, the contracting officer shall monitor the WDOL website to determine whether the applicable wage determination has been revised. Revisions published on the WDOL website or otherwise communicated to the... included in the resulting contract. Monitoring can be accomplished by use of the WDOL website's “Alert...

48 CFR 22.404-6 - Modifications of wage determinations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... solicitation, the contracting officer shall monitor the WDOL website to determine whether the applicable wage determination has been revised. Revisions published on the WDOL website or otherwise communicated to the... included in the resulting contract. Monitoring can be accomplished by use of the WDOL website's “Alert...

The biophysics of asthmatic airway smooth muscle.

PubMed

Stephens, Newman L; Li, Weilong; Jiang, He; Unruh, H; Ma, Xuefei

2003-09-16

It is clear that significant advances have been made in the understanding of the physiology, biochemistry and molecular biology of airway smooth muscle (ASM) contraction and how the knowledge obtained from these approaches may be used to elucidate the pathogenesis of asthma. Not to belittle other theories of smooth muscle contraction extant in the field, perhaps the most outstanding development has been the formulation of plasticity theory. This may radically alter our understanding of smooth muscle contraction. Its message is that while shortening velocity and capacity are linear functions of length, active force is length independent. These changes are explained by the ability of thick filament protein to depolymerize at short lengths and to increase numbers of contractile units in series at lengths greater than optimal length or L(ref). Other advances are represented by the report that the major part of ASM shortening is complete within the initial first 20% of contraction time, that the nature and history of loading determine the extent of shortening and that these findings can be explained by the finding that the crossbridges are cycling four times faster than in the remaining time. Another unexpected finding is that late in the course of isotonic relaxation the muscle undergoes spontaneous activation which delays relaxation and smoothes it out; speculatively this could minimize turbulence of airflow. On the applied front evidence now shows the shortening ability of bronchial smooth muscle of human subjects of asthma is significantly increased. Measurements also indicate that increased smooth muscle myosin light chain kinase content, via increased actomyosin ATPase activity could be responsible for the changes in contractility.

Crystal Growth Furnace (CGF)

NASA Technical Reports Server (NTRS)

Billingsley, Charles E.; Frederick, Larry

1993-01-01

The contract baseline, contract requirements review, contract modifications, contract problem areas and conclusions are addressed. Contract baseline was established 11 June 1987 and updated 1 December 1989. Significant changes were introduced into the 1989 baseline as compared to the original baseline. Contract modifications were made to add requirements as the program matured and as definition of requirements were completed. Problems were solved in real time through the contractor/customer team involvement and relationship to assure a timely and successful mission. The conclusion is that the CGF performed as designed and the experiments performed during the USML-1 Mission supports the conclusion.

Determining the optimal mix of federal and contract fire crews: a case study from the Pacific Northwest.

Treesearch

Geoffrey H. Donovan

2006-01-01

Federal land management agencies in the United States are increasingly relying on contract crews as opposed to agency fire crews. Despite this increasing reliance on contractors, there have been no studies to determine what the optimal mix of contract and agency fire crews should be. A mathematical model is presented to address this question and is applied to a case...

Psychological contract breaches, organizational commitment, and innovation-related behaviors: a latent growth modeling approach.

PubMed

Ng, Thomas W H; Feldman, Daniel C; Lam, Simon S K

2010-07-01

This study examined the relationships among psychological contract breaches, organizational commitment, and innovation-related behaviors (generating, spreading, implementing innovative ideas at work) over a 6-month period. Results indicate that the effects of psychological contract breaches on employees are not static. Specifically, perceptions of psychological contract breaches strengthened over time and were associated with decreased levels of affective commitment over time. Further, increased perceptions of psychological contract breaches were associated with decreases in innovation-related behaviors. We also found evidence that organizational commitment mediates the relationship between psychological contract breaches and innovation-related behaviors. These results highlight the importance of examining the nomological network of psychological contract breaches from a change perspective.

76 FR 21810 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items (DFARS Case...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... required to fully and adequately document the contract file regarding the market research performed by the... commercial determination is made before contract award. This determination is based on market research, an...

29 CFR 4204.11 - Variance of the bond/escrow and sale-contract requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... determining the purchaser's average net income after taxes under § 4204.13(a)(1), for any year included in the... financial statements for the specified time period. (d) Limited exemption during pendency of request...) within 30 days after the date on which it receives notice of the plan's decision. (e) Method and date of...

Job Order Contracting: A Procurement Success Story

DTIC Science & Technology

1988-02-01

Engineering/Procurement processing time 279 CI4 TABLE C-2 JOC DELIVERY ORDER PROCESSING TIME Contract size and location Amount Elapsed time- ($000) days...Bragg 2.1 68 Monroe 2.1 196 Sill 2.2 3 bragg 2.3 32 C-5 Ii ~A¶A~.AL&A .LiA..hLI TABLE C-2 JOC DELIVERY ORDER PROCESSING TIME (Continued) Conrat szean...DEUVERY ORDER PROCESSING TIME (Continued) Amount Elapsed time- Contract size and location Amou daps($000) days Bragg S 14.7 11 Monroe 14.8 30 Monroe

[Regulatory role of hypoxia inducible factor-1 alpha in the changes of contraction of vascular smooth muscle cell induced by hypoxia].

PubMed

Zhang, Yuan; Liu, Liang-ming; Ming, Jia; Yang, Guang-ming; Chen, Wei

2007-11-01

To observe the regulatory role and mechanism of hypoxia inducible factor-1 alpha (HIF-1 alpha) in the contractile changes of vascular smooth muscle cell (VSMC) induced by hypoxia. Cells were divided into three groups: normal, hypoxia and oligomycin treated groups. VSMC and vascular endothelial cell (VEC) were co-cultured in Transwell models with the hypoxic time of 0, 0.5, 1, 2, 3, 4 and 6 hours respectively. The contractile response of VSMC to norepinephrine were determined by measuring the fluorescent infiltration rate in the lower chamber. The mRNA expression of HIF-1 alpha, endothelial-nitric oxide synthase (eNOS), inducible-nitric oxide synthase(iNOS), heme oxygenase-1 (HO-1) and cyclooxygenase-2 (COX-2) were determined by reverse transcription-polymerase chain reaction (RT-PCR). VSMC contraction was increased at the early stage of hypoxia with the 1.53-fold increase at 0.5 hour as compared to the normal group (P<0 .01), and decreased gradually at the prolonged period of hypoxia with the drop of 30% at 6 hours as compared to the normal group (P<0.05). Oligomycin treatment significantly inhibited the increase of VSMC contraction at early stage, while improved it at late hypoxic period with the 6 hours increase of 12.8% (P<0.05). HIF-1 alpha, iNOS, COX-2 and HO-1 mRNA exhibited a time-dependent increase following hypoxia, and peaked at 6, 2, 3 and 4 hours respectively, they were increased 1.62, 3.23, 2.26 and 2.86-folds as compared with normal group (all P<0.01). iNOS, COX-2 and HO-1 mRNA expression were fluctuated in the normal range following oligomycin administration (all P>0.05). Hypoxia can elicit a biphasic changes of VSMC contraction, and HIF-1 alpha seems to play an important role in the regulation of VSMC contraction induced by hypoxia by regulating eNOS, iNOS, COX-2 and HO-1 expression.

33 CFR 211.109 - Contract of sale.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Contract of sale. 211.109 Section... Navigation Project in Oklahoma, to Former Owners § 211.109 Contract of sale. Upon determination of the price... District Engineer will prepare a contract of sale containing the terms and conditions of the reconveyance...

7 CFR 1410.51 - Transfer of land.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of, the land subject to a CRP contract, as determined by the Deputy Administrator, such new owner or operator, upon the approval of CCC, may become a participant to a new CRP contract with CCC for the... existing CRP contract, the new owner or operator shall assume all obligations of the CRP contract of the...

48 CFR 227.674 - Supply contracts between the Government and a foreign government or concern.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracts between the Government and a foreign government or concern. In negotiating contract prices with a second source, including the redetermination of contract prices, or in determining the allowability of... patent rights, rights in data, and other technical assistance provided to the second source, including...

25 CFR 900.168 - Will an appeal hurt the Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2012 CFR

2012-04-01

... organization's position in other contract negotiations? 900.168 Section 900.168 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals Other Than... Indian tribe or tribal organization's position in other contract negotiations? No. A pending appeal will...

25 CFR 900.168 - Will an appeal hurt the Indian tribe or tribal organization's position in other contract...

Code of Federal Regulations, 2010 CFR

2010-04-01

... organization's position in other contract negotiations? 900.168 Section 900.168 Indians BUREAU OF INDIAN... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Appeals Appeals Other Than... Indian tribe or tribal organization's position in other contract negotiations? No. A pending appeal will...

48 CFR 32.904 - Determining payment due dates.

Code of Federal Regulations, 2014 CFR

2014-10-01

... is subject to contract settlement actions (e.g., release of claims), acceptance is deemed to occur on...) Construction contracts. (1) The due date for making payments on construction contracts is as follows: (i) The... by the clause at 52.232-5, Payments Under Fixed-Price Construction Contracts. (ii) The due date for...

Detergent-Specific Membrane Protein Crystallization Screens

NASA Technical Reports Server (NTRS)

Wiener, Michael

2007-01-01

A suite of reagents has been developed for three-dimensional crystallization of integral membranes present in solution as protein-detergent complexes (PDCs). The compositions of these reagents have been determined in part by proximity to the phase boundaries (lower consolute boundaries) of the detergents present in the PDCs. The acquisition of some of the requisite phase-boundary data and the preliminary design of several of the detergent- specific screens was supported by a NASA contract. At the time of expiration of the contract, a partial set of preliminary screens had been developed. This work has since been extended under non-NASA sponsorship, leading to near completion of a set of 20 to 30 different and unique detergent- specific 96-condition screens.

41 CFR 101-27.506 - Determination of acceptability for credit.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-INVENTORY MANAGEMENT 27.5-Return of GSA Stock Items § 101-27.506 Determination of acceptability for credit... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Determination of acceptability for credit. 101-27.506 Section 101-27.506 Public Contracts and Property Management Federal...

25 CFR 900.38 - Do these standards apply to the subcontractors of an Indian tribe or tribal organization carrying...

Code of Federal Regulations, 2011 CFR

2011-04-01

... Indian tribe or tribal organization carrying out a self-determination contract? 900.38 Section 900.38... the subcontractors of an Indian tribe or tribal organization carrying out a self-determination... HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT...

25 CFR 900.38 - Do these standards apply to the subcontractors of an Indian tribe or tribal organization carrying...

Code of Federal Regulations, 2012 CFR

2012-04-01

... Indian tribe or tribal organization carrying out a self-determination contract? 900.38 Section 900.38... the subcontractors of an Indian tribe or tribal organization carrying out a self-determination... HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT...

25 CFR 900.38 - Do these standards apply to the subcontractors of an Indian tribe or tribal organization carrying...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Indian tribe or tribal organization carrying out a self-determination contract? 900.38 Section 900.38... the subcontractors of an Indian tribe or tribal organization carrying out a self-determination... HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT...

25 CFR 900.38 - Do these standards apply to the subcontractors of an Indian tribe or tribal organization carrying...

Code of Federal Regulations, 2013 CFR

2013-04-01

... Indian tribe or tribal organization carrying out a self-determination contract? 900.38 Section 900.38... the subcontractors of an Indian tribe or tribal organization carrying out a self-determination... HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT...

25 CFR 900.38 - Do these standards apply to the subcontractors of an Indian tribe or tribal organization carrying...

Code of Federal Regulations, 2014 CFR

2014-04-01

... Indian tribe or tribal organization carrying out a self-determination contract? 900.38 Section 900.38... the subcontractors of an Indian tribe or tribal organization carrying out a self-determination... HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

29 CFR 4.5 - Contract specification of determined minimum wages and fringe benefits.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) apply. (3) For purposes of using WDOL databases containing prevailing wage determinations, the date of... stipulations contained in § 4.6 and any applicable wage determination issued by the Administrator or his... any contract subject to section 10 of the Act, the Administrator may require retroactive application...

M-wave, H- and V-reflex recruitment curves during maximal voluntary contraction.

PubMed

Racinais, Sebastien; Maffiuletti, Nicola A; Girard, Olivier

2013-08-01

To investigate whether the H reflex-M wave recruitment curves obtained during maximal voluntary contraction (MVC) differ from rest and to determine the stimulation intensities allowing to record stable reflex responses. Full recruitment curves (precision, 2 mA) were obtained from the soleus muscle in 14 volunteers at rest and during plantar flexion MVCs. Maximal M-wave reached significantly larger amplitude during MVC (+2.2 [0.4; 3.9] mV) for a higher stimulation intensity (+7.9 [-0.4; 16] mA). Similarly, maximal H-reflex reached significantly larger amplitude during MVC than at rest (+3.2 [0.9; 5.5] mV) for a much higher stimulation intensity (+17.7 [9.7; 25.7] mA). V-wave amplitude plateaued only when M-wave during MVC plateaued, that is, at higher intensity than M-wave at rest. V-wave was correlated to the maximal H-reflex during MVC (r = 0.79, P < 0.05). Electrically evoked potentials showed a specific recruitment curve during MVC with higher maximal values attained for higher stimulation intensities. Thus, recording reflex responses during MVC based on intensities determined at rest or as a percentage of M-wave may yield inaccurate results. V-wave presented a plateau for stimulation intensity of 1.5 times the onset of the resting M-wave plateau. Evoked potentials obtained during actual contractions should be normalized to M-waves obtained during contractions of the same force level.

48 CFR 42.1104 - Surveillance requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Surveillance requirements... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Production Surveillance and Reporting 42.1104 Surveillance requirements. (a) The contract administration office determines the extent of...

48 CFR 42.1104 - Surveillance requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Surveillance requirements... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Production Surveillance and Reporting 42.1104 Surveillance requirements. (a) The contract administration office determines the extent of...

48 CFR 42.1104 - Surveillance requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Surveillance requirements... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Production Surveillance and Reporting 42.1104 Surveillance requirements. (a) The contract administration office determines the extent of...

48 CFR 42.1104 - Surveillance requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Surveillance requirements... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Production Surveillance and Reporting 42.1104 Surveillance requirements. (a) The contract administration office determines the extent of...

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 742.1170-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance monitoring is a function of contract administration used to determine contractor progress towards achieving...

Ca2+-pumping impairment during repetitive fatiguing contractions in single myofibers: role of cross-bridge cycling

PubMed Central

Shiah, Amy A.; Gandra, Paulo G.; Hogan, Michael C.

2013-01-01

The energy cost of contractions in skeletal muscle involves activation of both actomyosin and sarcoplasmic reticulum (SR) Ca2+-pump (SERCA) ATPases, which together determine the overall ATP demand. During repetitive contractions leading to fatigue, the relaxation rate and Ca2+ pumping become slowed, possibly because of intracellular metabolite accumulation. The role of the energy cost of cross-bridge cycling during contractile activity on Ca2+-pumping properties has not been investigated. Therefore, we inhibited cross-bridge cycling by incubating isolated Xenopus single fibers with N-benzyl-p-toluene sulfonamide (BTS) to study the mechanisms by which SR Ca2+ pumping is impaired during fatiguing contractions. Fibers were stimulated in the absence (control) and presence of BTS and cytosolic calcium ([Ca2+]c) transients or intracellular pH (pHi) changes were measured. BTS treatment allowed normal [Ca2+]c transients during stimulation without cross-bridge activation. At the time point that tension was reduced to 50% in the control condition, the fall in the peak [Ca2+]c and the increase in basal [Ca2+]c did not occur with BTS incubation. The progressively slower Ca2+ pumping rate and the fall in pHi during repetitive contractions were reduced during BTS conditions. However, when mitochondrial ATP supply was blocked during contractions with BTS present (BTS + cyanide), there was no further slowing in SR Ca2+ pumping during contractions compared with the BTS-alone condition. Furthermore, the fall in pHi was significantly less during the BTS + cyanide condition than in the control conditions. These results demonstrate that factors related to the energetic cost of cross-bridge cycling, possibly the accumulation of metabolites, inhibit the Ca2+ pumping rate during fatiguing contractions. PMID:23678027

Acoustic Emission Determination of Deformation Mechanisms Leading to Failure of Naval Alloys. Volume 1

DTIC Science & Technology

1983-05-01

DThSRT)C- STE -CP- 18-83 Contract No. No024-10-C-5317 Acoustic Emission Determination of Deformation Mechanisms Leading to Failure of Naval Alloys J...mobile dislocation motion were both found to generate AE as well [34-36]. Phase transformations have also been known to cause AE for some time (29...of alloying constituents and the heat treatment resulted in a fairly broken, complex, microstructure. All three steels were of a tempered martensitic

Integration of actomyosin contractility with cell-cell adhesion during dorsal closure.

PubMed

Duque, Julia; Gorfinkiel, Nicole

2016-12-15

In this work, we combine genetic perturbation, time-lapse imaging and quantitative image analysis to investigate how pulsatile actomyosin contractility drives cell oscillations, apical cell contraction and tissue closure during morphogenesis of the amnioserosa, the main force-generating tissue during the dorsal closure in Drosophila We show that Myosin activity determines the oscillatory and contractile behaviour of amnioserosa cells. Reducing Myosin activity prevents cell shape oscillations and reduces cell contractility. By contrast, increasing Myosin activity increases the amplitude of cell shape oscillations and the time cells spend in the contracted phase relative to the expanded phase during an oscillatory cycle, promoting cell contractility and tissue closure. Furthermore, we show that in AS cells, Rok controls Myosin foci formation and Mbs regulates not only Myosin phosphorylation but also adhesion dynamics through control of Moesin phosphorylation, showing that Mbs coordinates actomyosin contractility with cell-cell adhesion during amnioserosa morphogenesis. © 2016. Published by The Company of Biologists Ltd.

Sex Differences in Arm Muscle Fatigability With Cognitive Demand in Older Adults.

PubMed

Pereira, Hugo M; Spears, Vincent C; Schlinder-Delap, Bonnie; Yoon, Tejin; Harkins, April; Nielson, Kristy A; Hoeger Bement, Marie; Hunter, Sandra K

2015-08-01

Muscle fatigability can increase when a stressful, cognitively demanding task is imposed during a low-force fatiguing contraction with the arm muscles, especially in women. Whether this occurs among older adults (>60 years) is currently unknown. We aimed to determine if higher cognitive demands, stratified by sex, increased fatigability in older adults (>60 years). Secondarily, we assessed if varying cognitive demand resulted in decreased steadiness and was explained by anxiety or cortisol levels. Seventeen older women (70±6 years) and 13 older men (71±5 years) performed a sustained, isometric, fatiguing contraction at 20% of maximal voluntary contraction until task failure during three sessions: high cognitive demand (high CD=mental subtraction by 13); low cognitive demand (low CD=mental subtraction by 1); and control (no subtraction). Fatigability was greater when high and low CD were performed during the fatiguing contraction for the women but not for the men. In women, time to failure with high CD was 16±8 minutes and with low CD was 17±4 minutes, both of which were shorter than time to failure in control contractions (21±7 minutes; high CD mean difference: 5 minutes [95% confidence interval {CI}, 0.78-9.89], p=0.02; low CD mean difference: 4 minutes [95% CI, 0.57-7.31], p=0.03). However, in men, no differences were detected in time to failure with cognitive demand (control: 13±5 minutes; high CD mean difference: -0.09 minutes [95% CI, -2.8 to 2.7], p=1.00; low CD mean difference: 0.75 minutes [95% CI, -1.1 to 2.6], p=0.85). Steadiness decreased (force fluctuations increased) more during high CD than control. Elevated anxiety, mean arterial pressure, and salivary cortisol levels in both men and women did not explain the greater fatigability during high CD. Older women but not men showed marked increases in fatigability when low or high CD was imposed during sustained static contractions with the elbow flexor muscles and contrasts with previous findings for the lower limb. Steadiness decreased in both sexes when high CD was imposed. Older women are susceptible to greater fatigability of the upper limb with heightened mental activity during sustained postural contractions, which are the foundation of many work-related tasks.

48 CFR 16.601 - Time-and-materials contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... awarded without adequate price competition (see 15.403-1(c)(1)), the contract shall specify separate fixed...-Commercial Item Acquisitions With Adequate Price Competition, in solicitations contemplating use of a Time... based on adequate price competition. If authorized by agency procedures, the contracting officer may...

A novel pattern of longitudinal muscle contraction with subthreshold pharyngeal stimulus: a possible mechanism of lower esophageal sphincter relaxation.

PubMed

Leslie, Eric; Bhargava, Valmik; Mittal, Ravinder K

2012-03-01

A subthreshold pharyngeal stimulus induces lower esophageal sphincter (LES) relaxation and inhibits progression of ongoing peristaltic contraction in the esophagus. Recent studies show that longitudinal muscle contraction of the esophagus may play a role in LES relaxation. Our goal was to determine whether a subthreshold pharyngeal stimulus induces contraction of the longitudinal muscle of the esophagus and to determine the nature of this contraction. Studies were conducted in 16 healthy subjects. High resolution manometry (HRM) recorded pressures, and high frequency intraluminal ultrasound (HFIUS) images recorded longitudinal muscle contraction at various locations in the esophagus. Subthreshold pharyngeal stimulation was induced by injection of minute amounts of water in the pharynx. A subthreshold pharyngeal stimulus induced strong contraction and caudal descent of the upper esophageal sphincter (UES) along with relaxation of the LES. HFIUS identified longitudinal muscle contraction of the proximal (3-5 cm below the UES) but not the distal esophagus. Pharyngeal stimulus, following a dry swallow, blocked the progression of dry swallow-induced peristalsis; this was also associated with UES contraction and descent along with the contraction of longitudinal muscle of the proximal esophagus. We identify a unique pattern of longitudinal muscle contraction of the proximal esophagus in response to subthreshold pharyngeal stimulus, which we propose may be responsible for relaxation of the distal esophagus and LES through the stretch sensitive activation of myenteric inhibitory motor neurons.

Personal Services Contracts. Is It Time to Lift the Ban

DTIC Science & Technology

2016-03-01

Defense AT&L: March-April 2016 42 Personal Services Contracts Is It Time to Lift the Ban? Steven A. Fasko Fasko is a professor of Contract...Carbondale and has extensive professional experience in both U.S. Army global logistics services and Veterans Administration personal services...integrated offices. One issue has remained unchanged: the risk of creating a de facto personal services contract due to this relationship. Personal

Ultrasound elastography-based assessment of the elasticity of the supraspinatus muscle and tendon during muscle contraction.

PubMed

Muraki, Takayuki; Ishikawa, Hiroaki; Morise, Shuhei; Yamamoto, Nobuyuki; Sano, Hirotaka; Itoi, Eiji; Izumi, Shin-ichi

2015-01-01

Although elasticity of the supraspinatus muscle and tendon is a useful parameter to represent the conditions of the supraspinatus muscle and tendon, assessment of the elasticity in clinical settings has not been established. The purpose of this study was to determine the elasticity of the supraspinatus muscle belly and tendon under different muscle contraction conditions using ultrasound real-time tissue elastography (RTE). Twenty-three healthy individuals participated in this study. Ultrasound RTE was used for elasticity measurements of the muscle belly and tendon of the supraspinatus muscle. The elasticity was defined as the ratio of strain in the tissues to that in an acoustic coupler (reference). A greater ratio indicated that the tissue was softer. Measurements were performed with study subjects in the lateral decubitus position at 10° of shoulder abduction under conditions of (1) no contraction, (2) isometric contraction without a weight, and (3) isometric contraction with a 1-kg weight. The intraclass correlation coefficient (ICC1,3) of 3 measurements under each condition ranged from 0.931 to 0.998, showing high intraobserver reliability. Strain ratios for both the supraspinatus muscle belly and tendon significantly decreased with increases in muscle contraction (P < .001). Ultrasound RTE with the acoustic coupler has the potential to noninvasively detect changes in the elasticity of the supraspinatus muscle belly and tendon that accompany varying levels of muscle contraction in clinical practice. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Service contract of Renault Kerax 440 truck with deductible and policy limit coverage modification

NASA Astrophysics Data System (ADS)

Bustami, Pasaribu, Udjianna. S.; Husniah, Hennie

2016-02-01

In this paper we discuss a service contracts with coverage modification that only offer preventive maintenance and corrective maintenance for Renault Kerax 440 Truck by service contract provider. Corrective maintenance costs is modified with deductible and policy limit during the period of the service contract. Demand for a service contract is only influenced by the price of the service contract, deductible, and policy limit offered by producer to consumer. The main problem in this thesis is determining the price of a service contract, deductible, and policy limit to get maximum profit for producer for each of service contract.

Does the Length of Elbow Flexors and Visual Feedback Have Effect on Accuracy of Isometric Muscle Contraction in Men after Stroke?

PubMed Central

Juodzbaliene, Vilma; Darbutas, Tomas; Skurvydas, Albertas

2016-01-01

The aim of the study was to determine the effect of different muscle length and visual feedback information (VFI) on accuracy of isometric contraction of elbow flexors in men after an ischemic stroke (IS). Materials and Methods. Maximum voluntary muscle contraction force (MVMCF) and accurate determinate muscle force (20% of MVMCF) developed during an isometric contraction of elbow flexors in 90° and 60° of elbow flexion were measured by an isokinetic dynamometer in healthy subjects (MH, n = 20) and subjects after an IS during their postrehabilitation period (MS, n = 20). Results. In order to evaluate the accuracy of the isometric contraction of the elbow flexors absolute errors were calculated. The absolute errors provided information about the difference between determinate and achieved muscle force. Conclusions. There is a tendency that greater absolute errors generating determinate force are made by MH and MS subjects in case of a greater elbow flexors length despite presence of VFI. Absolute errors also increase in both groups in case of a greater elbow flexors length without VFI. MS subjects make greater absolute errors generating determinate force without VFI in comparison with MH in shorter elbow flexors length. PMID:27042670

Visualization of synchronization of the uterine contraction signals: running cross-correlation and wavelet running cross-correlation methods.

PubMed

Oczeretko, Edward; Swiatecka, Jolanta; Kitlas, Agnieszka; Laudanski, Tadeusz; Pierzynski, Piotr

2006-01-01

In physiological research, we often study multivariate data sets, containing two or more simultaneously recorded time series. The aim of this paper is to present the cross-correlation and the wavelet cross-correlation methods to assess synchronization between contractions in different topographic regions of the uterus. From a medical point of view, it is important to identify time delays between contractions, which may be of potential diagnostic significance in various pathologies. The cross-correlation was computed in a moving window with a width corresponding to approximately two or three contractions. As a result, the running cross-correlation function was obtained. The propagation% parameter assessed from this function allows quantitative description of synchronization in bivariate time series. In general, the uterine contraction signals are very complicated. Wavelet transforms provide insight into the structure of the time series at various frequencies (scales). To show the changes of the propagation% parameter along scales, a wavelet running cross-correlation was used. At first, the continuous wavelet transforms as the uterine contraction signals were received and afterwards, a running cross-correlation analysis was conducted for each pair of transformed time series. The findings show that running functions are very useful in the analysis of uterine contractions.

48 CFR 225.872-6 - Audit.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Defense Procurement and Acquisition Policy (Contract Policy and International Contracting), ((703) 697... DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Other International Agreements and Coordination 225.872... for reciprocal “no-cost” audits of contracts and subcontracts (pre- and post-award). (b) To determine...

48 CFR 801.690-7 - Termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... should discuss a termination of contracting authority for cause with the servicing Human Resource Management Office to determine the impact, if any, on the contracting officer's continued employment. (c) All... OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and...

48 CFR 37.107 - Service Contract Act of 1965.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Service Contract Act of... Act of 1965. The Service Contract Act of 1965 (41 U.S.C. 351-357) (the Act) provides for minimum wages... subpart 22.10). Whether or not the Act applies to a specific service contract will be determined by the...

47 CFR 1.781 - Requests for extension of filing time.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Complaints, Applications, Tariffs, and Reports Involving Common Carriers Contracts, Reports, and Requests... time within which to file contracts, reports, and requests referred to in §§ 1.783 through 1.814 shall be made in writing and may be granted for good cause shown. Contracts ...

Recovery from exercise at varying work loads - Time course of responses of heart rate and systolic intervals

NASA Technical Reports Server (NTRS)

Nandi, P. S.; Spodick, D. H.

1977-01-01

The time course of the recovery period was characterized by noninvasive measurements after 4 minute bicycle exercise at 3 separate work loads in volunteers with normal peak responses. Most responses started immediately to return toward resting control values. Left ventricular ejection time and stroke volume change are discussed. Changes in pre-ejection period were determined by changes in isovolume contraction time, and factors affecting the degree and rate of return are considered. The rates of change in the ejection time index and in the ratio pre-ejection period/left ventricular ejection time were virtually independent of load throughout most of recovery.

The Military Construction (MILCON) Program and Privatization: A Comparative Analysis

DTIC Science & Technology

1990-09-01

Government Contract Law , 1988: 13-4). The Davis-Bacon Act is implemented by Federal Acquisition Regulation (FAR) 22.400 and mandates that five provisions be...wages as determined by the Secretary of Labor (Dept. of the AF: Government Contract Law , 1988:13- 4). The Department of Labor wage determinations...Posting 4 - Withholding Payments 5 - Termination for Default 26 (Dept. of the AF: Government Contract Law , 1988: 13-4, 13-5) The residential schedule rates

41 CFR 101-25.202 - Factors to be used to determine assignment of purchase responsibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... experience of agency purchasing and contracting officials and their operating units with due regard to... determine assignment of purchase responsibility. 101-25.202 Section 101-25.202 Public Contracts and Property... PROCUREMENT 25-GENERAL 25.2-Interagency Purchase Assignments § 101-25.202 Factors to be used to determine...

The Long-Lasting Enhancing Effect of Distigmine on Acetylcholine-Induced Contraction of Guinea Pig Detrusor Smooth Muscle Correlates with Its Anticholinesterase Activity.

PubMed

Obara, Keisuke; Ogawa, Tsukasa; Chino, Daisuke; Tanaka, Yoshio

2017-01-01

Distigmine bromide (distigmine), a reversible, long-lasting cholinesterase (ChE) inhibitor, is used for the treatment of underactive bladder in Japan and has been shown to potentiate urinary bladder (UB) contractility. We studied the duration of distigmine's potentiating effects on acetylcholine (ACh)-induced UB contraction and its inhibitory effects on ChE activity, and compared that with those of other ChE inhibitors (neostigmine, pyridostigmine, and ambenonium). The duration of potentiating/inhibitory effects of ChE inhibitors, including distigmine, on ACh-induced guinea pig UB contraction/ChE activity was evaluated for 12 h following washout. Dissociation rate constants (k) of the inhibitors were also tentatively calculated based on the time courses of their ChE inhibitory effects. The potentiating effect of distigmine (10 -6  M) on ACh-induced UB contraction and its inhibitory effect on ChE activity were significantly sustained 12 h after washout. The potentiating effect of other ChE inhibitors on ACh-induced UB contraction, however, was sustained only until 3 h after washout. The ChE inhibitory effects of these inhibitors dissipated in a time-dependent manner after washout, with more than 75% of ChE activity restored by 4 h after washout. The k values of ChE inhibitors approached 0.50 h -1 , except for distigmine, where k could not be determined. Compared with that of other ChE inhibitors, the potentiating effect of distigmine on UB contractile function was significantly more sustainable following washout, which was likely associated with its corresponding long-lasting ChE inhibitory effect. Distigmine may associate more strongly with UB ChE than other ChE inhibitors, which would partly explain its sustained effects.

Motor unit recruitment strategies and muscle properties determine the influence of synaptic noise on force steadiness

PubMed Central

Dideriksen, Jakob L.; Negro, Francesco; Enoka, Roger M.

2012-01-01

Motoneurons receive synaptic inputs from tens of thousands of connections that cause membrane potential to fluctuate continuously (synaptic noise), which introduces variability in discharge times of action potentials. We hypothesized that the influence of synaptic noise on force steadiness during voluntary contractions is limited to low muscle forces. The hypothesis was examined with an analytical description of transduction of motor unit spike trains into muscle force, a computational model of motor unit recruitment and rate coding, and experimental analysis of interspike interval variability during steady contractions with the abductor digiti minimi muscle. Simulations varied contraction force, level of synaptic noise, size of motor unit population, recruitment range, twitch contraction times, and level of motor unit short-term synchronization. Consistent with the analytical derivations, simulations and experimental data showed that force variability at target forces above a threshold was primarily due to low-frequency oscillations in neural drive, whereas the influence of synaptic noise was almost completely attenuated by two low-pass filters, one related to convolution of motoneuron spike trains with motor unit twitches (temporal summation) and the other attributable to summation of single motor unit forces (spatial summation). The threshold force above which synaptic noise ceased to influence force steadiness depended on recruitment range, size of motor unit population, and muscle contractile properties. This threshold was low (<10% of maximal force) for typical values of these parameters. Results indicate that motor unit recruitment and muscle properties of a typical muscle are tuned to limit the influence of synaptic noise on force steadiness to low forces and that the inability to produce a constant force during stronger contractions is mainly attributable to the common low-frequency oscillations in motoneuron discharge rates. PMID:22423000

48 CFR 970.0970-1 - Determination of responsibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... providing all necessary financial, personnel, and other resources in performance of the contract. (b... very limited financial and other resources. In such instances, when making the determination of responsibility required under this section, the contracting officer may evaluate the financial resources of other...

30 CFR 1206.57 - Determination of transportation allowances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Determination of transportation allowances... transportation allowances. (a) Arm's-length transportation contracts. (1)(i) For transportation costs incurred by a lessee under an arm's-length contract, the transportation allowance shall be the reasonable...

25 CFR 900.3 - Policy statements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT General Provisions... the measure of self-determination essential to their social and economic well-being. (4) Congress has... has declared that there not be any threshold issues which would avoid the declination, contract review...

25 CFR 900.3 - Policy statements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT General Provisions... the measure of self-determination essential to their social and economic well-being. (4) Congress has... has declared that there not be any threshold issues which would avoid the declination, contract review...

25 CFR 900.3 - Policy statements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT General Provisions... the measure of self-determination essential to their social and economic well-being. (4) Congress has... has declared that there not be any threshold issues which would avoid the declination, contract review...

25 CFR 900.3 - Policy statements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT General Provisions... the measure of self-determination essential to their social and economic well-being. (4) Congress has... has declared that there not be any threshold issues which would avoid the declination, contract review...

25 CFR 900.3 - Policy statements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT General Provisions... the measure of self-determination essential to their social and economic well-being. (4) Congress has... has declared that there not be any threshold issues which would avoid the declination, contract review...

Haemodynamic kinetics and intermittent finger flexor performance in rock climbers.

PubMed

Fryer, S; Stoner, L; Lucero, A; Witter, T; Scarrott, C; Dickson, T; Cole, M; Draper, N

2015-02-01

Currently it is unclear whether blood flow (BF) or muscle oxidative capacity best governs performance during intermittent contractions to failure. The aim of this study was to determine oxygenation kinetics and BF responses during intermittent (10 s contraction: 3 s release) contractions at 40% of MVC in rock climbers of different ability (N=38). Total forearm BF, as well as de-oxygenation and re-oxygenation of the flexor digitorum profundus (FDP) and the flexor carpi radialis (FCR) were assessed. Compared to the control, intermediate and advanced groups, the elite climbers had a significantly (p<0.05) greater force time integral (FTI), MVC and MVC/kg. Furthermore, the elite climbers de-oxygenated the FDP significantly more during the first (7.8, 11.9, 12.4 vs. 15.7 O2%) and middle (7.3, 8.8, 10.4 vs.15.3 O2%) phases of contractions as well as for the FCR during the first phase only (8.3, 7, 11.7 vs. 13.3 O2%). They also had a significantly higher BF upon release of the contractions (656, 701, 764 vs. 971 mL ∙ min(-1)). The higher FTI seen in elite climbers may be attributable to a greater blood delivery, and an enhanced O2 recovery during the 3 s release periods, as well as a superior muscle oxidative capacity associated with the greater de-oxygenation during the 10 s contractions. © Georg Thieme Verlag KG Stuttgart · New York.

Natural gas price uncertainty and the cost-effectiveness of hedging against low hydropower revenues caused by drought

NASA Astrophysics Data System (ADS)

Kern, Jordan D.; Characklis, Gregory W.; Foster, Benjamin T.

2015-04-01

Prolonged periods of low reservoir inflows (droughts) significantly reduce a hydropower producer's ability to generate both electricity and revenues. Given the capital intensive nature of the electric power industry, this can impact hydropower producers' ability to pay down outstanding debt, leading to credit rating downgrades, higher interests rates on new debt, and ultimately, greater infrastructure costs. One potential tool for reducing the financial exposure of hydropower producers to drought is hydrologic index insurance, in particular, contracts structured to payout when streamflows drop below a specified level. An ongoing challenge in developing this type of insurance, however, is minimizing contracts' "basis risk," that is, the degree to which contract payouts deviate in timing and/or amount from actual damages experienced by policyholders. In this paper, we show that consideration of year-to-year changes in the value of hydropower (i.e., the cost of replacing it with an alternative energy source during droughts) is critical to reducing contract basis risk. In particular, we find that volatility in the price of natural gas, a key driver of peak electricity prices, can significantly degrade the performance of index insurance unless contracts are designed to explicitly consider natural gas prices when determining payouts. Results show that a combined index whose value is derived from both seasonal streamflows and the spot price of natural gas yields contracts that exhibit both lower basis risk and greater effectiveness in terms of reducing financial exposure.

7 CFR 4288.121 - Contract.

Code of Federal Regulations, 2013 CFR

2013-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General Provisions § 4288.121 Contract. Advanced biofuel producers determined to be eligible to receive payments must... Agency will forward the contract to the advanced biofuel producer. The advanced biofuel producer must...

7 CFR 4288.121 - Contract.

Code of Federal Regulations, 2012 CFR

2012-01-01

... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program General Provisions § 4288.121 Contract. Advanced biofuel producers determined to be eligible to receive payments must... Agency will forward the contract to the advanced biofuel producer. The advanced biofuel producer must...

48 CFR 837.103 - Contracting officer responsibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting officer responsibility. 837.103 Section 837.103 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... officer responsibility. When the contracting officer determines that legal assistance is necessary in...

40 CFR 35.937-9 - Required solicitation and subagreement provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

...; (2) The time for performance and completion of the contract work, including where appropriate, dates for completion of significant project tasks; (3) Personnel and facilities necessary to accomplish the... for later tasks or steps at the time of contract execution, the contract should not include the...

7 CFR 1726.303 - Promulgation of new or revised contract forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Promulgation of new or revised contract forms. 1726... UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES RUS Standard Forms § 1726.303 Promulgation of new or revised contract forms. RUS may, from time to time...

48 CFR 12.207 - Contract type.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracts or fixed-price contracts with economic price adjustment for the acquisition of commercial items... fixed-price with economic price adjustment contracts (e.g., by limiting the value or length of the time... maximize the use of firm-fixed-price or fixed-price with economic price adjustment contracts on future...

36 CFR 51.11 - May the Director amend, extend, or cancel a prospectus or solicitation?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., extend, or cancel a prospectus or solicitation? 51.11 Section 51.11 Parks, Forests, and Public Property... Procedures § 51.11 May the Director amend, extend, or cancel a prospectus or solicitation? The Director may... cancel a solicitation at any time prior to award of the concession contract if the Director determines in...

75 FR 59195 - Federal Acquisition Regulation; Time-and-Materials (T&M) and Labor-Hour (LH) Contracts for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... suitable. At a minimum, the D&F shall-- (i) Include a description of the market research conducted (see 8... determination and findings is required to contain several elements, including a description of the market research performed for the acquisition and a description of the actions planned to maximize the use of...

48 CFR Appendix A to Chapter 2 - Armed Services Board of Contract Appeals

Code of Federal Regulations, 2014 CFR

2014-10-01

... time shall be determined by taking into account such factors as the size and complexity of the claim... sufficient notice to the other party, furnish a pre-hearing brief to the Board. (b) Post-Hearing Briefs—Post... punished by the Court as a contempt thereof. Rule 23. Ex Parte Communications No member of the Board or of...

Development of a Novel Method for Determination of Momentum Transport Parameters

NASA Astrophysics Data System (ADS)

Peters, Michael J.; Guttenfelder, Walter; Scotti, Filippo; Kaye, Stanley M.; Solomon, Wayne M.

2015-11-01

The toroidal momentum pinch velocity Vφ and diffusivity χφ in NSTX were previously determined from the transient response of the toroidal rotation Ω following applied n =3 magnetic perturbations that brake the plasma. Assuming Π = nmR2(-χϕ ∇Ω + Vϕ Ω), where the momentum flux Π is determined using TRANSP, these local analyses used fits to Ω and ∇Ω to obtain χϕ and Vϕ one flux surface at a time. This work attempts to improve the accuracy of the inferred χϕ(r) and Vϕ(r) profiles by utilizing many flux surfaces simultaneously. We employ nonlinear least-squares minimization that compares the entire perturbed rotation profile evolution Ω(r,t) against the profile evolution generated by solving the momentum transport equation. We compare the local and integrated approaches and discuss their limitations. We also apply the integrated approach to determine whether an additional residual stress contribution (independent of Ω or ∇Ω) can be inferred given experimental uncertainties. This work supported by the U.S. Department of Energy SULI program and contract DE-AC02-09/CH11466, as well as the LLNL contract DE-AC52-07NA27344.

Options for change in the NHS consultant contract.

PubMed

Clarke, R W; Gray, C

The lead negotiators for the management and consultant sides in an NHS trust in northern England responded to debate in their trust about consultant contracts by offering to research the attitudes of their peers towards a variety of contract options. The options tested included the current contract; models already examined in the trust and elsewhere, such as time sensitive and mild performance related contracts; and some more radical and speculative possibilities, including consultants franchising their services to the trust. Beyond the predictable conclusion that consultants would prefer no change while managers desired it, a time sensitive contract emerged as having potential for successful negotiation. On the other hand, neither consultants nor managers favoured a strict performance related contract or a fee for service contract. There was a strong similarity of opinion between the two groups on the relative salary values of the options, though the consultants consistently priced these higher than the managers.

Options for change in the NHS consultant contract.

PubMed Central

Clarke, R. W.; Gray, C.

1994-01-01

The lead negotiators for the management and consultant sides in an NHS trust in northern England responded to debate in their trust about consultant contracts by offering to research the attitudes of their peers towards a variety of contract options. The options tested included the current contract; models already examined in the trust and elsewhere, such as time sensitive and mild performance related contracts; and some more radical and speculative possibilities, including consultants franchising their services to the trust. Beyond the predictable conclusion that consultants would prefer no change while managers desired it, a time sensitive contract emerged as having potential for successful negotiation. On the other hand, neither consultants nor managers favoured a strict performance related contract or a fee for service contract. There was a strong similarity of opinion between the two groups on the relative salary values of the options, though the consultants consistently priced these higher than the managers. PMID:8086915

Effects of a compression garment on shoulder external rotation force outputs during isotonic contractions.

PubMed

Tsuruike, Masaaki; Ellenbecker, Todd S

2013-02-01

The use of compression garments (CGs) has been advocated for performance enhancement and recovery in athletes. The effect of a CG on humeral rotation motor control has not been previously tested. The purpose of this study was to examine the isotonic contraction of external rotation (ER) of the glenohumeral joint at different force outputs to determine the effect of wearing a long sleeve CG on muscular performance. Twelve male college tennis players and 12 male college soccer players were tested for ER of the dominant shoulder during both concentric and eccentric isotonic contractions. The subjects performed 5 consecutive repetitions of both concentric and eccentric ER at 20-30% and 40-50% of maximum voluntary isometric contraction (MVIC) intensities. All subjects were tested with and without CG as well as with and without ongoing visual feedback information (OVFI). The order of CG wearing and the presence of OVFI were randomly assigned across all subjects. The results indicated a significant 3-way interaction between CG wearing and OVFI across 2 loads. Specifically, significantly different mean value of the completion time was found between OVFI and no-OVFI without CG wearing at 40-50% of MVIC, whereas no difference in the completion time was found with and without OVFI with CG wearing. Taken together, with CG wearing, athletes may have ER at 40-50% of MVIC more readily maintained by peripheral feedback without visuomotor control imposed on force outputs as compared without CG wearing.

Determining the Value of Contractor Performance Assessment Reporting System (CPARS) Narratives for the Acquisition Process

DTIC Science & Technology

2014-05-15

of the following tasks: sweep floors daily, mop floors with soap and water one time per week, wax floors one time per quarter, remove trash from...officer, nor does he/she hold any contracting authority. The FAR specifically states that a COR “has no authority to make any commitments or...key requirements to make sure everyone has the same view of the performance requirements. The customer states that they want the vendor to check

Physician Personal Services Contract Enforceability: The Influence of the Thirteenth Amendment.

PubMed

Fasko, Steven A; Kerr, Bernard J; Alvarez, M Raymond; Westrum, Andrew

We explore the influence of the Thirteenth Amendment to the US Constitution on the enforceability of personal services contracts for physicians. This influence extends from the ambiguous definition to the legal interpretation of personal services contracts. The courts have struggled with determining contracts to be a personal service and whether to grant injunctions for continued performance. The award or denial of damages due to a breach of contract is vested in these enforceability complications. Because of the Thirteenth Amendment's influence, courts and contracting parties will continue to struggle with physician personal services contract enforceability; although other points of view may exist. Possible solutions are offered for health care contract managers dealing with challenges attributable to physician personal services contracts.

25 CFR 1000.338 - What happens to a Tribe's/Consortium's mature contract status if it has retroceded a program that...

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 2 2013-04-01 2013-04-01 false What happens to a Tribe's/Consortium's mature contract...-DETERMINATION AND EDUCATION ACT Retrocession § 1000.338 What happens to a Tribe's/Consortium's mature contract...? Retrocession has no effect on mature contract status, provided that the 3 most recent audits covering...

Funding Solar Projects at Federal Agencies: Mechanisms and Selection Criteria (Brochure)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Implementing solar energy projects at federal facilities is a process. The project planning phase of the process includes determining goals, building a team, determining site feasibility and selecting the appropriate project funding tool. This fact sheet gives practical guidance to assist decision-makers with understanding and selecting the funding tool that would best address their site goals. Because project funding tools are complex, federal agencies should seek project assistance before making final decisions. High capital requirements combined with limits on federal agency energy contracts create challenges for funding solar projects. Solar developers typically require long-term contracts (15-20) years to spread outmore » the initial investment and to enable payments similar to conventional utility bill payments. In the private sector, 20-year contracts have been developed, vetted, and accepted, but the General Services Administration (GSA) contract authority (federal acquisition regulation [FAR] part 41) typically limits contract terms to 10 years. Payments on shorter-term contracts make solar economically unattractive compared with conventional generation. However, in several instances, the federal sector has utilized innovative funding tools that allow long-term contracts or has created a project package that is economically attractive within a shorter contract term.« less

Control of force during rapid visuomotor force-matching tasks can be described by discrete time PID control algorithms.

PubMed

Dideriksen, Jakob Lund; Feeney, Daniel F; Almuklass, Awad M; Enoka, Roger M

2017-08-01

Force trajectories during isometric force-matching tasks involving isometric contractions vary substantially across individuals. In this study, we investigated if this variability can be explained by discrete time proportional, integral, derivative (PID) control algorithms with varying model parameters. To this end, we analyzed the pinch force trajectories of 24 subjects performing two rapid force-matching tasks with visual feedback. Both tasks involved isometric contractions to a target force of 10% maximal voluntary contraction. One task involved a single action (pinch) and the other required a double action (concurrent pinch and wrist extension). 50,000 force trajectories were simulated with a computational neuromuscular model whose input was determined by a PID controller with different PID gains and frequencies at which the controller adjusted muscle commands. The goal was to find the best match between each experimental force trajectory and all simulated trajectories. It was possible to identify one realization of the PID controller that matched the experimental force produced during each task for most subjects (average index of similarity: 0.87 ± 0.12; 1 = perfect similarity). The similarities for both tasks were significantly greater than that would be expected by chance (single action: p = 0.01; double action: p = 0.04). Furthermore, the identified control frequencies in the simulated PID controller with the greatest similarities decreased as task difficulty increased (single action: 4.0 ± 1.8 Hz; double action: 3.1 ± 1.3 Hz). Overall, the results indicate that discrete time PID controllers are realistic models for the neural control of force in rapid force-matching tasks involving isometric contractions.

Real-time determination of sarcomere length of a single cardiomyocyte during contraction

PubMed Central

Kalda, Mari; Vendelin, Marko

2013-01-01

Sarcomere length of a cardiomyocyte is an important control parameter for physiology studies on a single cell level; for instance, its accurate determination in real time is essential for performing single cardiomyocyte contraction experiments. The aim of this work is to develop an efficient and accurate method for estimating a mean sarcomere length of a contracting cardiomyocyte using microscopy images as an input. The novelty in developed method lies in 1) using unbiased measure of similarities to eliminate systematic errors from conventional autocorrelation function (ACF)-based methods when applied to region of interest of an image, 2) using a semianalytical, seminumerical approach for evaluating the similarity measure to take into account spatial dependence of neighboring image pixels, and 3) using a detrend algorithm to extract the sarcomere striation pattern content from the microscopy images. The developed sarcomere length estimation procedure has superior computational efficiency and estimation accuracy compared with the conventional ACF and spectral analysis-based methods using fast Fourier transform. As shown by analyzing synthetic images with the known periodicity, the estimates obtained by the developed method are more accurate at the subpixel level than ones obtained using ACF analysis. When applied in practice on rat cardiomyocytes, our method was found to be robust to the choice of the region of interest that may 1) include projections of carbon fibers and nucleus, 2) have uneven background, and 3) be slightly disoriented with respect to average direction of sarcomere striation pattern. The developed method is implemented in open-source software. PMID:23255581

30 CFR 1206.262 - Determination of transportation allowances.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Determination of transportation allowances... transportation allowances. (a) Arm's-length contracts. (1) For transportation costs incurred by a lessee pursuant to an arm's-length contract, the transportation allowance shall be the reasonable, actual costs...

30 CFR 1206.262 - Determination of transportation allowances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Determination of transportation allowances... of transportation allowances. (a) Arm's-length contracts. (1) For transportation costs incurred by a lessee pursuant to an arm's-length contract, the transportation allowance shall be the reasonable, actual...

30 CFR 1206.262 - Determination of transportation allowances.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Determination of transportation allowances... transportation allowances. (a) Arm's-length contracts. (1) For transportation costs incurred by a lessee pursuant to an arm's-length contract, the transportation allowance shall be the reasonable, actual costs...

30 CFR 1206.461 - Determination of transportation allowances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Determination of transportation allowances... of transportation allowances. (a) Arm's-length contracts. (1) For transportation costs incurred by a lessee pursuant to an arm's-length contract, the transportation allowance shall be the reasonable, actual...

30 CFR 1206.262 - Determination of transportation allowances.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Determination of transportation allowances... transportation allowances. (a) Arm's-length contracts. (1) For transportation costs incurred by a lessee pursuant to an arm's-length contract, the transportation allowance shall be the reasonable, actual costs...

42 CFR 417.406 - Application and determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE PREPAYMENT PLANS Qualifying Conditions for Medicare Contracts § 417.406 Application and determination. (a... forth in § 417.407. (2) If an entity no longer meets those requirements, CMS terminates the contract of...

23 CFR 973.204 - Management systems requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... tribal management systems under a self-determination contract or self-governance annual funding agreement... consultation with the tribes, or the tribes under a self-determination contract or self-governance annual... transportation plans and transportation improvement programs and in making project selection decisions under 23 U...

23 CFR 973.204 - Management systems requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... tribal management systems under a self-determination contract or self-governance annual funding agreement... consultation with the tribes, or the tribes under a self-determination contract or self-governance annual... transportation plans and transportation improvement programs and in making project selection decisions under 23 U...

41 CFR 101-5.104-7 - Administrator's determination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Administrator's determination. 101-5.104-7 Section 101-5.104-7 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 5-CENTRALIZED SERVICES IN...

48 CFR 209.104-4 - Subcontractor responsibility.

Code of Federal Regulations, 2012 CFR

2012-10-01

...'s (CCC) proposal of a firm as its subcontractor is sufficient basis for an affirmative determination of responsibility. However, when the CCC determination of responsibility is not consistent with other information available to the contracting officer, the contracting officer shall request from CCC and any other...

48 CFR 209.104-4 - Subcontractor responsibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

...'s (CCC) proposal of a firm as its subcontractor is sufficient basis for an affirmative determination of responsibility. However, when the CCC determination of responsibility is not consistent with other information available to the contracting officer, the contracting officer shall request from CCC and any other...

Conscientiousness and reactions to psychological contract breach: a longitudinal field study.

PubMed

Orvis, Karin A; Dudley, Nicole M; Cortina, Jose M

2008-09-01

The authors examined the role of employee conscientiousness as a moderator of the relationships between psychological contract breach and employee behavioral and attitudinal reactions to the breach. They collected data from 106 newly hired employees within the 1st month of employment (Time 1), 3 months later (Time 2), and 8 months after Time 1 (Time 3) to observe the progression through contract development, breach, and reaction. Results suggest that conscientiousness is a significant moderator for 4 of the 5 contract breach-employee reaction relationships examined (turnover intentions, organizational loyalty, job satisfaction, and 1 of 2 facets of job performance). Specifically, employees who were lower in conscientiousness had more negative reactions to perceived breach with respect to turnover intentions, organizational loyalty, and job satisfaction. In contrast, employees who were higher in conscientiousness reduced their job performance to a greater degree in response to contract breach. Future research directions are discussed.

48 CFR 815.404-1 - Proposal analysis techniques.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical reviews. (See 801.602-70.) (b) Contracting officers determine the level of technical analyses... under them, and contract modifications. Contracting officers must request technical analyses of the proposals from the appropriate technical personnel. The technical analyses must address, as a minimum, the...

48 CFR 815.404-1 - Proposal analysis techniques.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technical reviews. (See 801.602-70.) (b) Contracting officers determine the level of technical analyses... under them, and contract modifications. Contracting officers must request technical analyses of the proposals from the appropriate technical personnel. The technical analyses must address, as a minimum, the...

48 CFR 1417.206 - Evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Evaluation. 1417.206 Section 1417.206 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1417.206 Evaluation. The determination in FAR 17.206(b...

48 CFR 2917.207 - Exercising options.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Exercising options. 2917... AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2917.207 Exercising options. The contracting officer must use a standardized determination and finding before exercising an option in accordance with...

48 CFR 301.602-3 - Ratification of unauthorized commitments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICES GENERAL HHS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and... legal review is necessary, the HCA or CCO shall coordinate the request for ratification with the Office...) The Contracting Officer shall review the submitted material and, if the Contracting Officer determines...

A novel pattern of longitudinal muscle contraction with subthreshold pharyngeal stimulus: a possible mechanism of lower esophageal sphincter relaxation

PubMed Central

Leslie, Eric; Bhargava, Valmik

2012-01-01

A subthreshold pharyngeal stimulus induces lower esophageal sphincter (LES) relaxation and inhibits progression of ongoing peristaltic contraction in the esophagus. Recent studies show that longitudinal muscle contraction of the esophagus may play a role in LES relaxation. Our goal was to determine whether a subthreshold pharyngeal stimulus induces contraction of the longitudinal muscle of the esophagus and to determine the nature of this contraction. Studies were conducted in 16 healthy subjects. High resolution manometry (HRM) recorded pressures, and high frequency intraluminal ultrasound (HFIUS) images recorded longitudinal muscle contraction at various locations in the esophagus. Subthreshold pharyngeal stimulation was induced by injection of minute amounts of water in the pharynx. A subthreshold pharyngeal stimulus induced strong contraction and caudal descent of the upper esophageal sphincter (UES) along with relaxation of the LES. HFIUS identified longitudinal muscle contraction of the proximal (3–5 cm below the UES) but not the distal esophagus. Pharyngeal stimulus, following a dry swallow, blocked the progression of dry swallow-induced peristalsis; this was also associated with UES contraction and descent along with the contraction of longitudinal muscle of the proximal esophagus. We identify a unique pattern of longitudinal muscle contraction of the proximal esophagus in response to subthreshold pharyngeal stimulus, which we propose may be responsible for relaxation of the distal esophagus and LES through the stretch sensitive activation of myenteric inhibitory motor neurons. PMID:22173917

Postural effects on the noninvasive baselines of ventricular performance

NASA Technical Reports Server (NTRS)

Lance, V. Q.; Spodick, D. H.

1977-01-01

The effects of posture on time-based noninvasive measurements were determined utilizing the sequence supine-sitting-standing in a formal protocol in which observer biases were eliminated by blinding the measurement and calculation phases. Compared to the supine posture, the sitting and standing postures produced significant increases in heart rate, isovolumic contraction time, pre-ejection period and pre-ejection period/left-ventricular ejection time and significant decreases in ejection time and ejection time index. The response patterns are consistent with the hemodynamic correlates cited in the literature which show increased adrenergic activity and decreased venous return in the sitting and standing postures, the effect on venous return being dominant.

25 CFR 900.131 - What role does the Secretary play during the performance of a self-determination construction...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What role does the Secretary play during the performance... CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Construction § 900.131 What role does the Secretary play during the performance of a self-determination construction contract? (a) If...

41 CFR 301-11.624 - What steps must my agency take to determine my ITRA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What steps must my agency take to determine my ITRA? 301-11.624 Section 301-11.624 Public Contracts and Property Management... Responsibilities § 301-11.624 What steps must my agency take to determine my ITRA? Your agency should: (a...

41 CFR 301-11.524 - What steps must my agency take to determine my ITRA?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What steps must my agency take to determine my ITRA? 301-11.524 Section 301-11.524 Public Contracts and Property Management... Responsibilities § 301-11.524 What steps must my agency take to determine my ITRA? Your agency should: (a...

Adaptive strength gains in dystrophic muscle exposed to repeated bouts of eccentric contraction

PubMed Central

Call, Jarrod A.; Eckhoff, Michael D.; Baltgalvis, Kristen A.; Warren, Gordon L.

2011-01-01

The objective of this study was to determine the functional recovery and adaptation of dystrophic muscle to multiple bouts of contraction-induced injury. Because lengthening (i.e., eccentric) contractions are extremely injurious for dystrophic muscle, it was considered that repeated bouts of such contractions would exacerbate the disease phenotype in mdx mice. Anterior crural muscles (tibialis anterior and extensor digitorum longus) and posterior crural muscles (gastrocnemius, soleus, and plantaris) from mdx mice performed one or five repeated bouts of 100 electrically stimulated eccentric contractions in vivo, and each bout was separated by 10–18 days. Functional recovery from one bout was achieved 7 days after injury, which was in contrast to a group of wild-type mice, which still showed a 25% decrement in electrically stimulated isometric torque at that time point. Across bouts there was no difference in the immediate loss of strength after repeated bouts of eccentric contractions for mdx mice (−70%, P = 0.68). However, after recovery from each bout, dystrophic muscle had greater torque-generating capacity such that isometric torque was increased ∼38% for both anterior and posterior crural muscles at bout 5 compared with bout 1 (P < 0.001). Moreover, isolated extensor digitorum longus muscles excised from in vivo-tested hindlimbs 14–18 days after bout 5 had greater specific force than contralateral control muscles (12.2 vs. 10.4 N/cm2, P = 0.005) and a 20% greater maximal relaxation rate (P = 0.049). Additional adaptations due to the multiple bouts of eccentric contractions included rapid recovery and/or sparing of contractile proteins, enhanced parvalbumin expression, and a decrease in fiber size variability. In conclusion, eccentric contractions are injurious to dystrophic skeletal muscle; however, the muscle recovers function rapidly and adapts to repeated bouts of eccentric contractions by improving strength. PMID:21960659

17 CFR Appendix B to Part 43 - Enumerated Physical Commodity Contracts and Other Contracts

Code of Federal Regulations, 2012 CFR

2012-04-01

... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Enumerated Physical Commodity... TRADING COMMISSION REAL-TIME PUBLIC REPORTING Pt. 43, App. B Appendix B to Part 43—Enumerated Physical Commodity Contracts and Other Contracts Enumerated Physical Commodity Contracts Agriculture ICE Futures U.S...

Unraveling endothelin-1 induced hypercontractility of human pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension

PubMed Central

Warburton, Rod; Taylor, Linda; Toksoz, Deniz; Hill, Nicholas; Polgar, Peter

2018-01-01

Contraction of human pulmonary artery smooth muscle cells (HPASMC) isolated from pulmonary arterial hypertensive (PAH) and normal (non-PAH) subject lungs was determined and measured with real-time electrical impedance. Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells. Inhibition with LIMKi3 and a cofilin targeted motif mimicking cell permeable peptide (MMCPP) had no effect on ET-1 induced HPASMC contraction indicating a negligible role for these actin regulatory proteins. On the other hand, a MMCPP blocking the activity of caldesmon reduced ET-1 promoted contraction pointing to a regulatory role of this protein and its activation pathway in HPASMC contraction. Inhibition of this MEK/ERK/p90RSK pathway, which is an upstream regulator of caldesmon phosphorylation, reduced ET-1 induced cell contraction. While the regulation of ET-1 induced cell contraction was found to be similar in PAH and non-PAH cells, a key difference was the response to pharmacological inhibitors and to siRNA knockdown of Rho kinases (ROCK1/ROCK2). The PAH cells required much higher concentrations of inhibitors to abrogate ET-1 induced contractions and their contraction was not affected by siRNA against either ROCK1 or ROCK2. Lastly, blocking of L-type and T-type Ca2+ channels had no effect on ET-1 or BK induced contraction. However, inhibiting the activity of the sarcoplasmic reticulum Ca2+ ATPase blunted ET-1 and BK induced HPASMC contraction in both PAH and non-PAH derived HPASMC. In summary, our findings here together with previous communications illustrate similarities and differences in the regulation PAH and non-PAH smooth muscle cell contraction relating to calcium translocation, RhoA/ROCK signaling and the activity of caldesmon. These findings may provide useful tools in achieving the regulation of the vascular hypercontractility taking place in PAH. PMID:29649319

Turnaround Time and Market Capacity in Contract Cheating

ERIC Educational Resources Information Center

Wallace, Melisa J.; Newton, Philip M.

2014-01-01

Contract cheating is the process whereby students auction off the opportunity for others to complete assignments for them. It is an apparently widespread yet under-researched problem. One suggested strategy to prevent contract cheating is to shorten the turnaround time between the release of assignment details and the submission date, thus making…

9 CFR 206.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... pricing determination included in a contract that establishes a minimum and/or maximum level of base price... premiums or discounts, expressed in dollars per unit. Contract. Any agreement, whether written or verbal... accrues a running positive or negative balance as a result of a pricing determination included in a...

25 CFR 900.35 - What is the purpose of this subpart?

Code of Federal Regulations, 2012 CFR

2012-04-01

... Indian tribes or tribal organizations when carrying out self-determination contracts. It provides..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems General § 900.35 What is the...

25 CFR 900.35 - What is the purpose of this subpart?

Code of Federal Regulations, 2011 CFR

2011-04-01

... Indian tribes or tribal organizations when carrying out self-determination contracts. It provides..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems General § 900.35 What is the...

25 CFR 900.35 - What is the purpose of this subpart?

Code of Federal Regulations, 2014 CFR

2014-04-01

... Indian tribes or tribal organizations when carrying out self-determination contracts. It provides..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems General § 900.35 What is the...

25 CFR 900.35 - What is the purpose of this subpart?

Code of Federal Regulations, 2013 CFR

2013-04-01

... Indian tribes or tribal organizations when carrying out self-determination contracts. It provides..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems General § 900.35 What is the...

25 CFR 900.35 - What is the purpose of this subpart?

Code of Federal Regulations, 2010 CFR

2010-04-01

... Indian tribes or tribal organizations when carrying out self-determination contracts. It provides..., DEPARTMENT OF HEALTH AND HUMAN SERVICES CONTRACTS UNDER THE INDIAN SELF-DETERMINATION AND EDUCATION ASSISTANCE ACT Standards for Tribal or Tribal Organization Management Systems General § 900.35 What is the...

48 CFR 31.201-4 - Determining allocability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Determining allocability. 31.201-4 Section 31.201-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... for the contract; (b) Benefits both the contract and other work, and can be distributed to them in...

41 CFR 60-2.14 - Determining availability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Determining availability. 60-2.14 Section 60-2.14 Public Contracts and Property Management Other Provisions Relating to Public... 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.14...

41 CFR 60-2.14 - Determining availability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Determining availability. 60-2.14 Section 60-2.14 Public Contracts and Property Management Other Provisions Relating to Public... 2-AFFIRMATIVE ACTION PROGRAMS Purpose and Contents of Affirmative Action Programs § 60-2.14...

Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy

NASA Astrophysics Data System (ADS)

Belau, Markus; Ninck, Markus; Hering, Gernot; Spinelli, Lorenzo; Contini, Davide; Torricelli, Alessandro; Gisler, Thomas

2010-09-01

We introduce a method for noninvasively measuring muscle contraction in vivo, based on near-infrared diffusing-wave spectroscopy (DWS). The method exploits the information about time-dependent shear motions within the contracting muscle that are contained in the temporal autocorrelation function g(1)(τ,t) of the multiply scattered light field measured as a function of lag time, τ, and time after stimulus, t. The analysis of g(1)(τ,t) measured on the human M. biceps brachii during repetitive electrical stimulation, using optical properties measured with time-resolved reflectance spectroscopy, shows that the tissue dynamics giving rise to the speckle fluctuations can be described by a combination of diffusion and shearing. The evolution of the tissue Cauchy strain e(t) shows a strong correlation with the force, indicating that a significant part of the shear observed with DWS is due to muscle contraction. The evolution of the DWS decay time shows quantitative differences between the M. biceps brachii and the M. gastrocnemius, suggesting that DWS allows to discriminate contraction of fast- and slow-twitch muscle fibers.

Analysis, comparison, and contrast of two primary maintenance contracting techniques used by the Florida Department of Transportation.

DOT National Transportation Integrated Search

2016-08-01

The Florida Department of Transportations (FDOT) Asset Maintenance Contracting Program (AMC) was analyzed during this study to determine if it reduced cost or affected work quality when compared with more-traditional contracts. A survey was conduc...

48 CFR 719.271-3 - USAID contracting officers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contracts to SDB for screening (see 719.271-6); (h) Taking action to assure that unnecessary qualifications... determinations, the contracting officer shall consider the recommendations, if any, of SDB together with the... small minority business enterprises, to SDB for information and advice; (k) Promoting increased...

48 CFR 719.271-3 - USAID contracting officers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracts to SDB for screening (see 719.271-6); (h) Taking action to assure that unnecessary qualifications... determinations, the contracting officer shall consider the recommendations, if any, of SDB together with the... small minority business enterprises, to SDB for information and advice; (k) Promoting increased...

48 CFR 719.271-3 - USAID contracting officers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contracts to SDB for screening (see 719.271-6); (h) Taking action to assure that unnecessary qualifications... determinations, the contracting officer shall consider the recommendations, if any, of SDB together with the... small minority business enterprises, to SDB for information and advice; (k) Promoting increased...

48 CFR 719.271-3 - USAID contracting officers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contracts to SDB for screening (see 719.271-6); (h) Taking action to assure that unnecessary qualifications... determinations, the contracting officer shall consider the recommendations, if any, of SDB together with the... small minority business enterprises, to SDB for information and advice; (k) Promoting increased...

24 CFR 985.109 - Default under the Annual Contributions Contract (ACC).

Code of Federal Regulations, 2011 CFR

2011-04-01

... Contributions Contract (ACC). 985.109 Section 985.109 Housing and Urban Development REGULATIONS RELATING TO... § 985.109 Default under the Annual Contributions Contract (ACC). HUD may determine that an PHA's failure... required by HUD constitutes a default under the ACC. ...

24 CFR 985.109 - Default under the Annual Contributions Contract (ACC).

Code of Federal Regulations, 2010 CFR

2010-04-01

... Contributions Contract (ACC). 985.109 Section 985.109 Housing and Urban Development Regulations Relating to... § 985.109 Default under the Annual Contributions Contract (ACC). HUD may determine that an PHA's failure... required by HUD constitutes a default under the ACC. ...

48 CFR 42.702 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... estimated rates subject to adjustment during contract performance and at the time the final indirect cost....702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT... under this subpart provides— (1) Uniformity of approach with a contractor when more than one contract or...

48 CFR 42.702 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-10-01

... estimated rates subject to adjustment during contract performance and at the time the final indirect cost....702 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT... under this subpart provides— (1) Uniformity of approach with a contractor when more than one contract or...

A resource-dependence model of hospital contract management.

PubMed Central

Alexander, J A; Morrisey, M A

1989-01-01

This study empirically examines the determinants of hospital entry into management contracts with multihospital systems. Using a resource-dependence framework, the study tests whether market conditions, regulatory climate, management effectiveness, and certain enabling factors affect the probability of hospital entry into a contract management arrangement. The study used a pooled sample of 312 contract-managed and 936 traditionally managed hospitals. Results suggest the importance of management effectiveness, regulatory climate, and hospital ownership (investor owned or nonprofit) as predisposing conditions of contract management. PMID:2732059

Do you know your business associates?

PubMed

Hinkley, Gerald M; Glitz, Rachel; Hirsch, W Reece

2003-01-01

HIPAA's business associate rules require covered entities to identify their business associates and enter into contracts with them to safeguard the privacy of individually identifiable health information. Covered entities need to determine who their business associates are and whether exceptions apply. Covered entities need to examine their business associate contracts to ensure that the contracts contain provisions required by HIPAA. Covered entities should not enter into business associate contracts unnecessarily. Existing business associate contracts are subject to a transition period for compliance with HIPAA.

Performance Contracting in Elementary and Secondary Education. A Report Showing the Developments on a Nationwide Basis and the Implications for New York State.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Div. of Evaluation.

This paper describes the historical development of performance contracting, discusses the first performance contracting experiment, cites reactions to performance contracting, and supplies supportive data. The contents are designed to assist the New York State Board of Regents to determine policy for the State Education Department and the New York…

Average chewing pattern improvements following Disclusion Time reduction.

PubMed

Kerstein, Robert B; Radke, John

2017-05-01

Studies involving electrognathographic (EGN) recordings of chewing improvements obtained following occlusal adjustment therapy are rare, as most studies lack 'chewing' within the research. The objectives of this study were to determine if reducing long Disclusion Time to short Disclusion Time with the immediate complete anterior guidance development (ICAGD) coronoplasty in symptomatic subjects altered their average chewing pattern (ACP) and their muscle function. Twenty-nine muscularly symptomatic subjects underwent simultaneous EMG and EGN recordings of right and left gum chewing, before and after the ICAGD coronoplasty. Statistical differences in the mean Disclusion Time, the mean muscle contraction cycle, and the mean ACP resultant from ICAGD underwent the Student's paired t-test (α = 0.05). Disclusion Time reductions from ICAGD were significant (2.11-0.45 s. p = 0.0000). Post-ICAGD muscle changes were significant in the mean area (p = 0.000001), the peak amplitude (p = 0.00005), the time to peak contraction (p < 0.000004), the time to 50% peak contraction (p < 0.00001), and in the decreased number of silent periods per side (right p < 0.0000002; left p < 0.0000006). Post-ICAGD ACP changes were also significant; the terminal chewing position became closer to centric occlusion (p < 0.002), the maximum and average chewing velocities increased (p < 0.002; p < 0.00005), the opening and closing times, the cycle time, and the occlusal contact time all decreased (p < 0.004-0.0001). The average chewing pattern (ACP) shape, speed, consistency, muscular coordination, and vertical opening improvements can be significantly improved in muscularly dysfunctional TMD patients within one week's time of undergoing the ICAGD enameloplasty. Computer-measured and guided occlusal adjustments quickly and physiologically improved chewing, without requiring the patients to wear pre- or post-treatment appliances.

Efficient preloading of the ventricles by a properly timed atrial contraction underlies stroke work improvement in the acute response to cardiac resynchronization therapy

PubMed Central

Hu, Yuxuan; Gurev, Viatcheslav; Constantino, Jason; Trayanova, Natalia

2013-01-01

Background The acute response to cardiac resynchronization therapy (CRT) has been shown to be due to three mechanisms: resynchronization of ventricular contraction, efficient preloading of the ventricles by a properly timed atrial contraction, and mitral regurgitation reduction. However, the contribution of each of the three mechanisms to the acute response of CRT, specifically stroke work improvement, has not been quantified. Objective The goal of this study was to use an MRI-based anatomically accurate 3D model of failing canine ventricular electromechanics to quantify the contribution of each of the three mechanisms to stroke work improvement and identify the predominant mechanisms. Methods An MRI-based electromechanical model of the failing canine ventricles assembled previously by our group was further developed and modified. Three different protocols were used to dissect the contribution of each of the three mechanisms to stroke work improvement. Results Resynchronization of ventricular contraction did not lead to significant stroke work improvement. Efficient preloading of the ventricles by a properly timed atrial contraction was the predominant mechanism underlying stroke work improvement. Stroke work improvement peaked at an intermediate AV delay, as it allowed ventricular filling by atrial contraction to occur at a low diastolic LV pressure but also provided adequate time for ventricular filling before ventricular contraction. Diminution of mitral regurgitation by CRT led to stroke work worsening instead of improvement. Conclusion Efficient preloading of the ventricles by a properly timed atrial contraction is responsible for significant stroke work improvement in the acute CRT response. PMID:23928177

Time-related changes in firing rates are influenced by recruitment threshold and twitch force potentiation in the first dorsal interosseous.

PubMed

Miller, Jonathan D; Herda, Trent J; Trevino, Michael A; Sterczala, Adam J; Ciccone, Anthony B

2017-08-01

What is the central question of this study? The influences of motor unit recruitment threshold and twitch force potentiation on the changes in firing rates during steady-force muscular contractions are not well understood. What is the main finding and its importance? The behaviour of motor units during steady force was influenced by recruitment threshold, such that firing rates decreased for lower-threshold motor units but increased for higher-threshold motor units. In addition, individuals with greater changes in firing rates possessed greater twitch force potentiation. There are contradictory reports regarding changes in motor unit firing rates during steady-force contractions. Inconsistencies are likely to be the result of previous studies disregarding motor unit recruitment thresholds and not examining firing rates on a subject-by-subject basis. It is hypothesized that firing rates are manipulated by twitch force potentiation during contractions. Therefore, in this study we examined time-related changes in firing rates at steady force in relationship to motor unit recruitment threshold in the first dorsal interosseous and the influence of twitch force potentiation on such changes in young versus aged individuals. Subjects performed a 12 s steady-force contraction at 50% maximal voluntary contraction, with evoked twitches before and after the contraction to quantify potentiation. Firing rates, in relationship to recruitment thresholds, were determined at the beginning, middle and end of the steady force. There were no firing rate changes for aged individuals. For the young, firing rates decreased slightly for lower-threshold motor units but increased for higher-threshold motor units. Twitch force potentiation was greater for young than aged subjects, and changes in firing rates were correlated with twitch force potentiation. Thus, individuals with greater increases in firing rates of higher-threshold motor units and decreases in lower-threshold motor units possessed greater twitch force potentiation. Overall, changes in firing rates during brief steady-force contractions are dependent on recruitment threshold and explained in part by twitch force potentiation. Given that firing rate changes were measured in relationship to recruitment threshold, this study illustrates a more complete view of firing rate changes during steady-force contractions. © 2017 The Authors. Experimental Physiology © 2017 The Physiological Society.

Human skeletal muscle metabolic economy in vivo: effects of contraction intensity, age, and mobility impairment

PubMed Central

Christie, Anita D.; Tonson, Anne; Larsen, Ryan G.; DeBlois, Jacob P.

2014-01-01

We tested the hypothesis that older muscle has greater metabolic economy (ME) in vivo than young, in a manner dependent, in part, on contraction intensity. Twenty young (Y; 24 ± 1 yr, 10 women), 18 older healthy (O; 73 ± 2, 9 women) and 9 older individuals with mild-to-moderate mobility impairment (OI; 74 ± 1, 7 women) received stimulated twitches (2 Hz, 3 min) and performed nonfatiguing voluntary (20, 50, and 100% maximal; 12 s each) isometric dorsiflexion contractions. Torque-time integrals (TTI; Nm·s) were calculated and expressed relative to maximal fat-free muscle cross-sectional area (cm2), and torque variability during voluntary contractions was calculated as the coefficient of variation. Total ATP cost of contraction (mM) was determined from flux through the creatine kinase reaction, nonoxidative glycolysis and oxidative phosphorylation, and used to calculate ME (Nm·s·cm−2·mM ATP−1). While twitch torque relaxation was slower in O and OI compared with Y (P ≤ 0.001), twitch TTI, ATP cost, and economy were similar across groups (P ≥ 0.15), indicating comparable intrinsic muscle economy during electrically induced isometric contractions in vivo. During voluntary contractions, normalized TTI and total ATP cost did not differ significantly across groups (P ≥ 0.20). However, ME was lower in OI than Y or O at 20% and 50% MVC (P ≤ 0.02), and torque variability was greater in OI than Y or O at 20% MVC (P ≤ 0.05). These results refute the hypothesis of greater muscle ME in old age, and provide support for lower ME in impaired older adults as a potential mechanism or consequence of age-related reductions in functional mobility. PMID:25163917

Aging alters contractile properties and fiber morphology in pigeon skeletal muscle.

PubMed

Pistilli, Emidio E; Alway, Stephen E; Hollander, John M; Wimsatt, Jeffrey H

2014-12-01

In this study, we tested the hypothesis that skeletal muscle from pigeons would display age-related alterations in isometric force and contractile parameters as well as a shift of the single muscle fiber cross-sectional area (CSA) distribution toward smaller fiber sizes. Maximal force output, twitch contraction durations and the force-frequency relationship were determined in tensor propatagialis pars biceps muscle from young 3-year-old pigeons, middle-aged 18-year-old pigeons, and aged 30-year-old pigeons. The fiber CSA distribution was determined by planimetry from muscle sections stained with hematoxylin and eosin. Maximal force output of twitch and tetanic contractions was greatest in muscles from young pigeons, while the time to peak force of twitch contractions was longest in muscles from aged pigeons. There were no changes in the force-frequency relationship between the age groups. Interestingly, the fiber CSA distribution in aged muscles revealed a greater number of larger sized muscle fibers, which was verified visually in histological images. Middle-aged and aged muscles also displayed a greater amount of slow myosin containing muscle fibers. These data demonstrate that muscles from middle-aged and aged pigeons are susceptible to alterations in contractile properties that are consistent with aging, including lower force production and longer contraction durations. These functional changes were supported by the appearance of slow myosin containing muscle fibers in muscles from middle-aged and aged pigeons. Therefore, the pigeon may represent an appropriate animal model for the study of aging-related alterations in skeletal muscle function and structure.

Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice

PubMed Central

Martin, Sara M.; Holle, Lori A.; Cooley, Brian C.; Flick, Matthew J.

2018-01-01

The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting red blood cell (RBC) retention. However, the key source of FXIII and whether FXIII activity can be reduced to suppress thrombosis without imposing deleterious hemostatic consequences are 2 critical unresolved questions. FXIII is present in multiple compartments, including plasma (FXIIIplasma) as a heterotetramer of A2 and B2 subunits and platelets (FXIIIplt) as an A2 homodimer. We determined the role of the FXIII compartment and level in clot contraction, composition, and size in vitro and using in vivo models of hemostasis and venous thrombosis. Reducing overall FXIII levels decreased whole blood clot weight but did not alter thrombin generation or contraction of platelet-rich plasma clots. In reconstituted platelet-rich plasma and whole blood clot contraction assays, FXIIIplasma, but not FXIIIplt, produced high-molecular-weight fibrin crosslinks, promoted RBC retention, and increased clot weights. Genetically imposed reduction of FXIII delayed FXIII activation and fibrin crosslinking, suggesting FXIII levels mediate the kinetics of FXIII activation and activity and that the timing of these processes is a critical determinant of RBC retention during clot formation and contraction. A 50% reduction in FXIIIplasma produced significantly smaller venous thrombi but did not increase bleeding in tail transection or saphenous vein puncture models in vivo. Collectively, these findings suggest that partial FXIII reduction may be a therapeutic strategy for reducing venous thrombosis. PMID:29344582

Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice.

PubMed

Kattula, Sravya; Byrnes, James R; Martin, Sara M; Holle, Lori A; Cooley, Brian C; Flick, Matthew J; Wolberg, Alisa S

2018-01-09

The transglutaminase factor XIII (FXIII) stabilizes clots against mechanical and biochemical disruption and is essential for hemostasis. In vitro and in vivo models of venous thrombosis demonstrate that FXIII mediates clot size by promoting red blood cell (RBC) retention. However, the key source of FXIII and whether FXIII activity can be reduced to suppress thrombosis without imposing deleterious hemostatic consequences are 2 critical unresolved questions. FXIII is present in multiple compartments, including plasma (FXIII plasma ) as a heterotetramer of A 2 and B 2 subunits and platelets (FXIII plt ) as an A 2 homodimer. We determined the role of the FXIII compartment and level in clot contraction, composition, and size in vitro and using in vivo models of hemostasis and venous thrombosis. Reducing overall FXIII levels decreased whole blood clot weight but did not alter thrombin generation or contraction of platelet-rich plasma clots. In reconstituted platelet-rich plasma and whole blood clot contraction assays, FXIII plasma , but not FXIII plt , produced high-molecular-weight fibrin crosslinks, promoted RBC retention, and increased clot weights. Genetically imposed reduction of FXIII delayed FXIII activation and fibrin crosslinking, suggesting FXIII levels mediate the kinetics of FXIII activation and activity and that the timing of these processes is a critical determinant of RBC retention during clot formation and contraction. A 50% reduction in FXIII plasma produced significantly smaller venous thrombi but did not increase bleeding in tail transection or saphenous vein puncture models in vivo. Collectively, these findings suggest that partial FXIII reduction may be a therapeutic strategy for reducing venous thrombosis.

41 CFR 302-2.3 - What determines my entitlements and allowances for relocation?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What determines my entitlements and allowances for relocation? 302-2.3 Section 302-2.3 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES INTRODUCTION 2-EMPLOYEES ELIGIBILITY REQUIREMENTS...

41 CFR 60-2.17 - Additional required elements of affirmative action programs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... selection disparities; (3) Compensation system(s) to determine whether there are gender-, race-, or... determine whether they result in disparities in the employment or advancement of minorities or women; and (5... Other Provisions Relating to Public Contracts OFFICE OF FEDERAL CONTRACT COMPLIANCE PROGRAMS, EQUAL...

41 CFR 51-2.4 - Determination of suitability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Determination of suitability. 51-2.4 Section 51-2.4 Public Contracts and Property Management Other Provisions Relating to... performed and that it will have the capability to meet Government quality standards and delivery schedules...

41 CFR 51-2.4 - Determination of suitability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Determination of suitability. 51-2.4 Section 51-2.4 Public Contracts and Property Management Other Provisions Relating to... performed and that it will have the capability to meet Government quality standards and delivery schedules...