24 CFR 982.455 - Automatic termination of HAP contract.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Automatic termination of HAP contract. 982.455 Section 982.455 Housing and Urban Development Regulations Relating to Housing and Urban... Payments Contract and Owner Responsibility § 982.455 Automatic termination of HAP contract. The HAP...

48 CFR 49.601-2 - Letter notice.

Code of Federal Regulations, 2010 CFR

2010-10-01

... notice of termination is suggested for use if a contract for supplies is being terminated for convenience... termination; e.g., name and address of company, contract number of terminated contract, items, etc.] (a...'s convenience under the clause entitled _________ [insert title of appropriate termination clause...

48 CFR 52.222-12 - Contract Termination-Debarment.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Contract Termination—Debarment (FEB 1988) A breach of the contract clauses entitled Davis-Bacon Act... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract Termination... (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52...

48 CFR 1849.505-70 - NASA contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA contract clause. 1849.505-70 Section 1849.505-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 1849.505-70 NASA...

48 CFR 1849.505-70 - NASA contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA contract clause. 1849.505-70 Section 1849.505-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 1849.505-70 NASA...

48 CFR 1849.505-70 - NASA contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA contract clause. 1849.505-70 Section 1849.505-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 1849.505-70 NASA...

48 CFR 1849.505-70 - NASA contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA contract clause. 1849.505-70 Section 1849.505-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 1849.505-70 NASA...

48 CFR 1849.505-70 - NASA contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA contract clause. 1849.505-70 Section 1849.505-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 1849.505-70 NASA...

48 CFR 749.111-70 - Termination settlement review boards.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.111-70 Termination.... Delegate members of the board shall have broad business and contracting experience and shall be senior...

42 CFR 422.510 - Termination of contract by CMS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.510 Termination of contract by CMS. (a) Termination by CMS. CMS may at any...

48 CFR 249.7000 - Terminated contracts with Canadian Commercial Corporation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Canadian Commercial Corporation. 249.7000 Section 249.7000 Federal Acquisition Regulations System DEFENSE... Termination Requirements 249.7000 Terminated contracts with Canadian Commercial Corporation. (a) Terminate contracts with the Canadian Commercial Corporation in accordance with— (1) The Letter of Agreement (LOA...

48 CFR 249.7000 - Terminated contracts with Canadian Commercial Corporation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Canadian Commercial Corporation. 249.7000 Section 249.7000 Federal Acquisition Regulations System DEFENSE... Termination Requirements 249.7000 Terminated contracts with Canadian Commercial Corporation. (a) Terminate contracts with the Canadian Commercial Corporation in accordance with— (1) The Letter of Agreement (LOA...

48 CFR 249.7000 - Terminated contracts with Canadian Commercial Corporation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Canadian Commercial Corporation. 249.7000 Section 249.7000 Federal Acquisition Regulations System DEFENSE... Termination Requirements 249.7000 Terminated contracts with Canadian Commercial Corporation. (a) Terminate contracts with the Canadian Commercial Corporation in accordance with— (1) The Letter of Agreement (LOA...

48 CFR 49.502 - Termination for convenience of the Government.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Termination for convenience of the Government. 49.502 Section 49.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 49.502...

48 CFR 49.502 - Termination for convenience of the Government.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Termination for convenience of the Government. 49.502 Section 49.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 49.502...

48 CFR 49.502 - Termination for convenience of the Government.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Termination for convenience of the Government. 49.502 Section 49.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 49.502...

48 CFR 49.502 - Termination for convenience of the Government.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Termination for convenience of the Government. 49.502 Section 49.502 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Clauses 49.502...

7 CFR 400.205 - Denial or termination of contract and administrative reassignment of business.

Code of Federal Regulations, 2010 CFR

2010-01-01

... reassignment of business. 400.205 Section 400.205 Agriculture Regulations of the Department of Agriculture... administrative reassignment of business. Non-compliance with these standards will result in: (a) The denial of a Contract; or (b) Termination of an existing Contract. In the event of denial or termination of the Contract...

48 CFR 49.402-3 - Procedure for default.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting officer shall consider the following factors in determining whether to terminate a contract for... portion of the contract) is terminated; (4) That the supplies or services terminated may be purchased... of termination constitutes such decision, and that the contractor has the right to appeal such...

48 CFR 49.304 - Procedure for partial termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedure for partial termination. 49.304 Section 49.304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts...

42 CFR 423.510 - Termination of contract by the Part D sponsor.

Code of Federal Regulations, 2010 CFR

2010-10-01

... to the Part D plan sponsor ends as of the first day of the month after the last month for which the... 42 Public Health 3 2010-10-01 2010-10-01 false Termination of contract by the Part D sponsor. 423... Procedures and Contracts with Part D plan sponsors § 423.510 Termination of contract by the Part D sponsor...

48 CFR 49.206-1 - Submission of settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for... settlement proposals if they are determined under generally recognized accounting principles consistently...

48 CFR 49.208 - Equitable adjustment after partial termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Equitable adjustment after partial termination. 49.208 Section 49.208 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts...

48 CFR 49.402-6 - Repurchase against contractor's account.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Termination for Default 49.402-6 Repurchase against..., considering the quality and delivery requirements. The contracting officer may repurchase a quantity in excess... of the repurchase contract, make a written demand on the contractor for the total amount of the...

48 CFR 49.402-6 - Repurchase against contractor's account.

Code of Federal Regulations, 2011 CFR

2011-10-01

... REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Termination for Default 49.402-6 Repurchase against..., considering the quality and delivery requirements. The contracting officer may repurchase a quantity in excess... of the repurchase contract, make a written demand on the contractor for the total amount of the...

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: (1) Termination of contract by CMS. (i) CMS notifies the Part D plan in writing 90 days before the... difficulties so severe that its ability to make necessary health services available is impaired to the point of... writing that its contract will be terminated on a date specified by CMS. If a termination in is effective...

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: (1) Termination of contract by CMS. (i) CMS notifies the Part D plan in writing 90 days before the... difficulties so severe that its ability to make necessary health services available is impaired to the point of... writing that its contract will be terminated on a date specified by CMS. If a termination in is effective...

12 CFR 367.6 - Causes for exclusion.

Code of Federal Regulations, 2010 CFR

2010-01-01

... default; or (2) The termination of such contract(s) for poor performance; or (3) A violation of the terms of a contract that would have resulted in a default or termination of the contract for poor... lack of integrity, or conspiracy to do the same; (l) The contractor's performance under previous...

36 CFR 223.46 - Adjustment of contract termination date.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Adjustment of contract termination date. 223.46 Section 223.46 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Timber Sale Contracts Contract Conditions and...

48 CFR 49.603-4 - Cost-reimbursement contracts-complete termination, with settlement limited to fee.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Cost-reimbursement... Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS... conditions of the contract and parts 31 and 49 of the Federal Acquisition Regulation. [Insert subparagraph (3...

48 CFR 49.603-4 - Cost-reimbursement contracts-complete termination, with settlement limited to fee.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Cost-reimbursement... Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS... conditions of the contract and parts 31 and 49 of the Federal Acquisition Regulation. [Insert subparagraph (3...

48 CFR 49.603-4 - Cost-reimbursement contracts-complete termination, with settlement limited to fee.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Cost-reimbursement... Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS... conditions of the contract and parts 31 and 49 of the Federal Acquisition Regulation. [Insert subparagraph (3...

42 CFR 422.508 - Modification or termination of contract by mutual consent.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Application Procedures and Contracts for Medicare Advantage Organizations § 422.508 Modification or termination of contract...

26 CFR 1.6043-3 - Return regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2012 CFR

2012-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a). 1.6043-3..., dissolution, termination, or substantial contraction of organizations exempt from taxation under section 501(a... the organization was exempt from taxation under section 501(a) shall provide the information will...

26 CFR 1.6043-3 - Return regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2014 CFR

2014-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a). 1.6043-3..., dissolution, termination, or substantial contraction of organizations exempt from taxation under section 501(a... the organization was exempt from taxation under section 501(a) shall provide the information will...

26 CFR 1.6043-3 - Return regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2013 CFR

2013-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a). 1.6043-3..., dissolution, termination, or substantial contraction of organizations exempt from taxation under section 501(a... the organization was exempt from taxation under section 501(a) shall provide the information will...

26 CFR 1.6043-3T - Returns regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2011 CFR

2011-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a) (temporary... liquidation, dissolution, termination, or substantial contraction of organizations exempt from taxation under... (b)(7). (b)(8) Any organization no longer exempt from taxation under section 501(a) and that during...

26 CFR 1.6043-3 - Return regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2011 CFR

2011-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a). 1.6043-3..., dissolution, termination, or substantial contraction of organizations exempt from taxation under section 501(a... the organization was exempt from taxation under section 501(a) shall provide the information will...

48 CFR 49.202 - Profit.

Code of Federal Regulations, 2010 CFR

2010-10-01

....202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for Convenience 49.202...) Character and difficulty of subcontracting, including selection, placement, and management of subcontracts...

36 CFR 51.48 - What happens to a right of preference in the event of termination of a concession contract for...

Code of Federal Regulations, 2010 CFR

2010-07-01

... its terms at any time for less than satisfactory performance or otherwise. If a concession contract is terminated for less than satisfactory performance or other breach, the terminated concessioner, even if... terminated a concession contract for less than satisfactory performance or other breach will not limit the...

48 CFR 1652.249-71 - FEHBP termination for convenience of the government-negotiated benefits contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... convenience of the government-negotiated benefits contracts. 1652.249-71 Section 1652.249-71 Federal... convenience of the government—negotiated benefits contracts. As prescribed in section 1649.101-71, the following clause shall be inserted in all FEHBP contracts. FEHBP Termination for Convenience of the...

36 CFR 51.74 - When may a concession contract be terminated by the Director?

Code of Federal Regulations, 2014 CFR

2014-07-01

... contract be terminated by the Director? 51.74 Section 51.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR CONCESSION CONTRACTS Concession Contract Provisions § 51.74... include, but are not limited to, protecting, conserving, and preserving park area resources and providing...

36 CFR 51.74 - When may a concession contract be terminated by the Director?

Code of Federal Regulations, 2013 CFR

2013-07-01

... contract be terminated by the Director? 51.74 Section 51.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR CONCESSION CONTRACTS Concession Contract Provisions § 51.74... include, but are not limited to, protecting, conserving, and preserving park area resources and providing...

36 CFR 51.74 - When may a concession contract be terminated by the Director?

Code of Federal Regulations, 2011 CFR

2011-07-01

... contract be terminated by the Director? 51.74 Section 51.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR CONCESSION CONTRACTS Concession Contract Provisions § 51.74... include, but are not limited to, protecting, conserving, and preserving park area resources and providing...

36 CFR 51.74 - When may a concession contract be terminated by the Director?

Code of Federal Regulations, 2012 CFR

2012-07-01

... contract be terminated by the Director? 51.74 Section 51.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR CONCESSION CONTRACTS Concession Contract Provisions § 51.74... include, but are not limited to, protecting, conserving, and preserving park area resources and providing...

36 CFR 51.74 - When may a concession contract be terminated by the Director?

Code of Federal Regulations, 2010 CFR

2010-07-01

... contract be terminated by the Director? 51.74 Section 51.74 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR CONCESSION CONTRACTS Concession Contract Provisions § 51.74... include, but are not limited to, protecting, conserving, and preserving park area resources and providing...

7 CFR 1410.52 - Violations.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) If a participant fails to carry out the terms and conditions of a CRP contract, CCC may terminate the CRP contract. (2) If the CRP contract is terminated by CCC in accordance with this paragraph: (i) The...

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: (1) Termination of contract by CMS. (i) CMS notifies the Part D plan sponsor in writing at least 45... experiences financial difficulties so severe that its ability to make necessary health services available is...) CMS notifies the Part D plan sponsor in writing that its contract will be terminated on a date...

26 CFR 1.6043-3 - Return regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2010 CFR

2010-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a). 1.6043-3..., termination, or substantial contraction of organizations exempt from taxation under section 501(a). (a) In... organization was exempt from taxation under section 501(a) shall provide the information will respect to such...

26 CFR 1.6043-3T - Returns regarding liquidation, dissolution, termination, or substantial contraction of...

Code of Federal Regulations, 2010 CFR

2010-04-01

..., termination, or substantial contraction of organizations exempt from taxation under section 501(a) (temporary..., dissolution, termination, or substantial contraction of organizations exempt from taxation under section 501(a... organization no longer exempt from taxation under section 501(a) and that during the period of its exemption...

Insurance Contract Analysis for Company Decision Support in Acquisition Management

NASA Astrophysics Data System (ADS)

Chernovita, H. P.; Manongga, D.; Iriani, A.

2017-01-01

One of company activities to retain their business is marketing the products which include in acquisition management to get new customers. Insurance contract analysis using ID3 to produce decision tree and rules to be decision support for the insurance company. The decision tree shows 13 rules that lead to contract termination claim. This could be a guide for the insurance company in acquisition management to prevent contract binding with these contract condition because it has a big chance for the customer to terminate their insurance contract before its expired date. As the result, there are several strong points that could be the determinant of contract termination such as: 1) customer age whether too young or too old, 2) long insurance period (above 10 years), 3) big insurance amount, 4) big amount of premium charges, and 5) payment method.

48 CFR 49.206 - Settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Settlement proposals. 49.206 Section 49.206 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for...

48 CFR 49.301 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false General. 49.301 Section 49.301 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for Convenience 49...

48 CFR 49.204 - Deductions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Deductions. 49.204 Section 49.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for Convenience 49.204...

48 CFR 49.201 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

....201 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for Convenience 49.201... strict accounting principles, is the heart of a settlement. (b) The primary objective is to negotiate a...

48 CFR 801.690-7 - Termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... should discuss a termination of contracting authority for cause with the servicing Human Resource Management Office to determine the impact, if any, on the contracting officer's continued employment. (c) All... OF VETERANS AFFAIRS ACQUISITION REGULATION SYSTEM Career Development, Contracting Authority, and...

48 CFR 49.304-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false General. 49.304-1 Section 49.304-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for Convenience 49...

48 CFR 49.305-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false General. 49.305-1 Section 49.305-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for Convenience 49...

48 CFR 49.203 - Adjustment for loss.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Adjustment for loss. 49.203 Section 49.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for...

48 CFR 49.205 - Completed end items.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Completed end items. 49.205 Section 49.205 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for...

48 CFR 49.207 - Limitation on settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Limitation on settlements. 49.207 Section 49.207 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for...

48 CFR 49.302 - Discontinuance of vouchers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Discontinuance of vouchers. 49.302 Section 49.302 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for...

48 CFR 49.305 - Adjustment of fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Adjustment of fee. 49.305 Section 49.305 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for Convenience 49...

48 CFR 49.304-3 - Submission of vouchers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of vouchers. 49.304-3 Section 49.304-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for...

48 CFR 49.303-5 - Final settlement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Final settlement. 49.303-5 Section 49.303-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts Terminated for Convenience 49...

48 CFR 1649.101-71 - FEHBP termination for convenience clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1649.101-71 FEHBP termination for convenience clause. The clause set forth in...

48 CFR 49.206-2 - Bases for settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Bases for settlement proposals. 49.206-2 Section 49.206-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts Terminated for...

48 CFR 1649.101-72 - FEHBP termination for default clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1649.101-72 FEHBP termination for default clause. The clause set forth in 1652...

48 CFR 970.2306 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2306 Suspension of payments, termination of contract, and debarment and...

48 CFR 970.2306 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2306 Suspension of payments, termination of contract, and debarment and...

48 CFR 970.2306 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2306 Suspension of payments, termination of contract, and debarment and...

48 CFR 970.2306 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2306 Suspension of payments, termination of contract, and debarment and...

48 CFR 970.2306 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency, Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2306 Suspension of payments, termination of contract, and debarment and...

48 CFR 749.111-71 - Required review and approval.

Code of Federal Regulations, 2011 CFR

2011-10-01

... approval. 749.111-71 Section 749.111-71 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.111-71 Required review and... fee of a cost-reimbursement contract or subcontract and: (i) In the case of complete termination, the...

48 CFR 232.704-70 - Incrementally funded fixed-price contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING...'s decision and terminate for the convenience of the Government. (c) The contracting officer shall...

48 CFR 49.114 - Unsettled contract changes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Unsettled contract changes. 49.114 Section 49.114 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.114 Unsettled contract changes. (a) Before...

42 CFR 422.510 - Termination of contract by CMS.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: (1) Termination of contract by CMS. (i) CMS notifies the MA organization in writing 90 days before... organization; or (B) The MA organization experiences financial difficulties so severe that its ability to make...) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

42 CFR 422.510 - Termination of contract by CMS.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: (1) Termination of contract by CMS. (i) CMS notifies the MA organization in writing 90 days before... organization; or (B) The MA organization experiences financial difficulties so severe that its ability to make...) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

42 CFR 422.510 - Termination of contract by CMS.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Termination of contract by CMS. (i) CMS notifies the MA organization in writing 90 days before the intended...; or (B) The MA organization experiences financial difficulties so severe that its ability to make...) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

48 CFR 2149.002 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

...(c). (2) A life insurance contract entered into by OPM may be terminated by OPM at any time for default by the Contractor in accordance with the provisions of FAR part 49 and FAR 52.249-8. A life... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS 2149...

48 CFR 2149.002 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-10-01

...(c). (2) A life insurance contract entered into by OPM may be terminated by OPM at any time for default by the Contractor in accordance with the provisions of FAR part 49 and FAR 52.249-8. A life... GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS 2149...

7 CFR 1402.5 - Late payments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... payments. If payment is not received by CCC within the period specified in the sales contract, interest will be assessed by CCC. If a buyer fails to make arrangements for payment according to the provisions of the contract, CCC retains the right to terminate the sales contract. If CCC terminates the sales...

7 CFR 1402.5 - Late payments.

Code of Federal Regulations, 2012 CFR

2012-01-01

... payments. If payment is not received by CCC within the period specified in the sales contract, interest will be assessed by CCC. If a buyer fails to make arrangements for payment according to the provisions of the contract, CCC retains the right to terminate the sales contract. If CCC terminates the sales...

7 CFR 1402.5 - Late payments.

Code of Federal Regulations, 2013 CFR

2013-01-01

... payments. If payment is not received by CCC within the period specified in the sales contract, interest will be assessed by CCC. If a buyer fails to make arrangements for payment according to the provisions of the contract, CCC retains the right to terminate the sales contract. If CCC terminates the sales...

7 CFR 1402.5 - Late payments.

Code of Federal Regulations, 2011 CFR

2011-01-01

... payments. If payment is not received by CCC within the period specified in the sales contract, interest will be assessed by CCC. If a buyer fails to make arrangements for payment according to the provisions of the contract, CCC retains the right to terminate the sales contract. If CCC terminates the sales...

7 CFR 1402.5 - Late payments.

Code of Federal Regulations, 2014 CFR

2014-01-01

... payments. If payment is not received by CCC within the period specified in the sales contract, interest will be assessed by CCC. If a buyer fails to make arrangements for payment according to the provisions of the contract, CCC retains the right to terminate the sales contract. If CCC terminates the sales...

48 CFR 49.102 - Notice of termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Notice of termination. 49.102 Section 49.102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.102 Notice of termination. (a) General. The...

Contract Terminations for Default and Convenience.

DTIC Science & Technology

1981-06-01

principal rights acquired by the Government under the default clause, according to Govern- ment Contract Law (M8157), is the right to repurchase the 2 item...with the conver- sion of terminations from default to convenience in any detail (21:539). Government Contract Law presented an ex- cellent summary of...factors leading to the conversion were analyzed on the basis of the DAR, principles of contract law , and studies included in the literature review

48 CFR 749.111-70 - Termination settlement review boards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Termination settlement review boards. 749.111-70 Section 749.111-70 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.111-70 Termination...

48 CFR 49.105-1 - Termination status reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Termination status reports. 49.105-1 Section 49.105-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-1 Termination status reports. When...

24 CFR 206.131 - Contract rights and obligations for mortgages on individual dwelling units in a condominium.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Contract rights and obligations for... MORTGAGE INSURANCE Contract Rights and Obligations Condominiums § 206.131 Contract rights and obligations...] Termination of Insurance Contract ...

10 CFR 1706.7 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... decline to approve performance of a particular task by the contractor if an actual or potential OCI is...) Terminate the contract, or, in the case of a task order contract, terminate the particular task; (ii) Insist... contractor to continue to perform the contract (or task) under the waiver provisions of § 1706.8, and, where...

42 CFR 421.205 - Termination by the Secretary.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 3 2014-10-01 2014-10-01 false Termination by the Secretary. 421.205 Section 421... (CONTINUED) MEDICARE PROGRAM (CONTINUED) MEDICARE CONTRACTING Carriers § 421.205 Termination by the Secretary. (a) Cause for termination. The Secretary may terminate a contract with a carrier at any time if he or...

48 CFR 49.105-3 - Termination case file.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Termination case file. 49.105-3 Section 49.105-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-3 Termination case file. The TCO responsible...

48 CFR 49.105-3 - Termination case file.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Termination case file. 49.105-3 Section 49.105-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-3 Termination case file. The TCO responsible...

48 CFR 49.105-3 - Termination case file.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Termination case file. 49.105-3 Section 49.105-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-3 Termination case file. The TCO responsible...

48 CFR 49.105-3 - Termination case file.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Termination case file. 49.105-3 Section 49.105-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-3 Termination case file. The TCO responsible...

48 CFR 49.105-3 - Termination case file.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Termination case file. 49.105-3 Section 49.105-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-3 Termination case file. The TCO responsible...

48 CFR 32.305 - Loan guarantees for terminated contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... losses and to ensure the loans will be self-liquidating from the proceeds of defense production contracts... REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Loan Guarantees for Defense Production 32.305... financing based on the borrower's recoverable investment in defense production contracts, may also apply to...

48 CFR 32.305 - Loan guarantees for terminated contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... losses and to ensure the loans will be self-liquidating from the proceeds of defense production contracts... REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Loan Guarantees for Defense Production 32.305... financing based on the borrower's recoverable investment in defense production contracts, may also apply to...

48 CFR 32.305 - Loan guarantees for terminated contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... losses and to ensure the loans will be self-liquidating from the proceeds of defense production contracts... REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Loan Guarantees for Defense Production 32.305... financing based on the borrower's recoverable investment in defense production contracts, may also apply to...

48 CFR 32.305 - Loan guarantees for terminated contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... losses and to ensure the loans will be self-liquidating from the proceeds of defense production contracts... REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Loan Guarantees for Defense Production 32.305... financing based on the borrower's recoverable investment in defense production contracts, may also apply to...

48 CFR 32.305 - Loan guarantees for terminated contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... losses and to ensure the loans will be self-liquidating from the proceeds of defense production contracts... REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Loan Guarantees for Defense Production 32.305... financing based on the borrower's recoverable investment in defense production contracts, may also apply to...

48 CFR 415.404-4 - Profit.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Termination settlements; and (v) Cost-plus-award-fee contracts; (b) Unless otherwise restricted by contracting... CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 415.404-4 Profit. (a)(1) USDA will use a... negotiation is based on cost analysis. (2) The following types of acquisitions are exempt from the...

41 CFR 105-71.144 - Termination for convenience.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Termination for convenience. 105-71.144 Section 105-71.144 Public Contracts and Property Management Federal Property... Termination for convenience. Except as provided in § 105-71.143 awards may be terminated in whole or in part...

48 CFR 49.603-1 - Fixed-price contracts-complete termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Contractor certifies that all contract termination inventory (including scrap) has been retained or acquired... certificate stating (i) that all subcontract termination inventory (including scrap) has been retained or... certifies that all items of termination inventory, the costs of which were used in arriving at the amount of...

48 CFR 49.603-2 - Fixed-price contracts-partial termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... certifies that all contract termination inventory (including scrap) has been retained or acquired by the... stating (i) that all subcontract termination inventory (including scrap) has been retained or acquired by... certifies that all items of termination inventory, the costs of which were used in arriving at the amount of...

48 CFR 49.603-3 - Cost-reimbursement contracts-complete termination, if settlement includes cost.

Code of Federal Regulations, 2010 CFR

2010-10-01

... following: (1) The Contractor certifies that all contract termination inventory (including scrap) has been... the Contractor a certificate stating (i) that all subcontract termination inventory (including scrap... in its proposal. (3) The Contractor certifies that all items of termination inventory, the costs of...

Is There a Relationship between Training Quality and Premature Contract Terminations in VET?

ERIC Educational Resources Information Center

Negrini, Lucio; Forsblom, Lara; Gurtner, Jean-Luc; Schumann, Stephan

2016-01-01

The dominant organizational form of vocational education and training in Switzerland is the dual-track system, in which trainees sign an apprenticeship contract with a training company. Notably, 10% to 40% of those contracts are terminated prematurely each year, depending on region and occupational category, which is an important topic of concern…

48 CFR 52.232-29 - Terms for Financing of Purchases of Commercial Items.

Code of Federal Regulations, 2010 CFR

2010-10-01

... requested is properly due in accordance with this contract; the supplies deliverable or services due under... termination for cause. If this contract is terminated for cause, the Contractor shall, on demand, repay to the... other rights and remedies provided by law or this contract; and (ii) shall not be affected by delayed...

48 CFR 32.109 - Termination financing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Termination financing. 32... CONTRACTING REQUIREMENTS CONTRACT FINANCING Non-Commercial Item Purchase Financing 32.109 Termination financing. To encourage contractors to invest their own funds in performance despite the susceptibility of...

48 CFR 49.109-7 - Settlement by determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-7 Settlement by determination. (a... determination of the amount due consistent with the termination clause, including any cost principles...

48 CFR 49.402-8 - Reporting information.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Reporting information. 49... MANAGEMENT TERMINATION OF CONTRACTS Termination for Default 49.402-8 Reporting information. The contracting officer, in accordance with agency procedures, shall ensure that information relating to the termination...

24 CFR 203.464 - Effect of termination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Rehabilitation Loans § 203.464 Effect of termination. Upon termination of the contract of insurance, the obligation to pay any subsequent insurance...

24 CFR 203.464 - Effect of termination.

Code of Federal Regulations, 2011 CFR

2011-04-01

... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Rehabilitation Loans § 203.464 Effect of termination. Upon termination of the contract of insurance, the obligation to pay any subsequent insurance...

48 CFR 601.602-1 - Authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 601.602-1... contracting officer shall not award, modify, or terminate a contract unless all reviews, clearances, and...

42 CFR 421.205 - Termination by the Secretary.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for termination. The Secretary may terminate a contract with a carrier at any time if he or she... performed its function in a manner inconsistent with the effective and efficient administration of the... intent to terminate the contract, the carrier may request a hearing within 20 days after the date on the...

41 CFR 105-72.701 - Termination.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Termination. 105-72.701 Section 105-72.701 Public Contracts and Property Management Federal Property Management Regulations System... NON-PROFIT ORGANIZATIONS 72.70-Post-Award Requirements/Termination and Enforcement § 105-72.701...

41 CFR 105-72.701 - Termination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Termination. 105-72.701 Section 105-72.701 Public Contracts and Property Management Federal Property Management Regulations System... NON-PROFIT ORGANIZATIONS 72.70-Post-Award Requirements/Termination and Enforcement § 105-72.701...

48 CFR 609.405-70 - Termination action decision.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) For overseas posts, A/OPE. (b) Termination for default. Termination for default under a contract's default clause is appropriate when the circumstances giving rise to the debarment or suspension also constitute a default in the contractor's performance of that contract. Debarment or suspension of the...

48 CFR 249.105-1 - Termination status reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Termination status reports. 249.105-1 Section 249.105-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 249.105-1...

48 CFR 249.105-1 - Termination status reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Termination status reports. 249.105-1 Section 249.105-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 249.105-1...

48 CFR 249.105-1 - Termination status reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Termination status reports. 249.105-1 Section 249.105-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 249.105-1...

48 CFR 249.105-1 - Termination status reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Termination status reports. 249.105-1 Section 249.105-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 249.105-1...

48 CFR 249.105-1 - Termination status reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Termination status reports. 249.105-1 Section 249.105-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 249.105-1...

48 CFR 52.249-7 - Termination (Fixed-Price Architect-Engineer).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Termination (Fixed-Price... Clauses 52.249-7 Termination (Fixed-Price Architect-Engineer). As prescribed in 49.503(b), insert the following clause in solicitations and contracts for architect-engineer services when a fixed-price contract...

48 CFR 49.104 - Duties of prime contractor after receipt of notice of termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Duties of prime contractor after receipt of notice of termination. 49.104 Section 49.104 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.104...

48 CFR 49.602-5 - Settlement agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Settlement agreement. 49... MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.602-5 Settlement agreement... settlement agreement (see 49.109-1). ...

48 CFR 49.602-5 - Settlement agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Settlement agreement. 49... MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.602-5 Settlement agreement... settlement agreement (see 49.109-1). ...

48 CFR 49.602-5 - Settlement agreement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Settlement agreement. 49... MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.602-5 Settlement agreement... settlement agreement (see 49.109-1). ...

48 CFR 552.219-74 - Section 8(a) Direct Award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting activity shall give advance notice to SBA before it issues a final notice terminating performance... prior to processing any advance payments or novation agreements. The contracting activity may assign contract administration functions to a contract administration office. (c) The Contractor agrees: (1) To...

48 CFR 49.107 - Audit of prime contract settlement proposals and subcontract settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Audit of prime contract settlement proposals and subcontract settlements. 49.107 Section 49.107 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49...

Exclusive contracts in the hospital setting: a two-edged sword: part 2: pros and cons, avoidance strategies, and negotiating tips.

PubMed

Portman, Robert M

2007-06-01

Hospitals routinely enter into contracts with radiology groups for the right to be the exclusive providers of radiologic services at the facilities in exchange for the groups' agreeing to provide and manage all aspects of those services within the hospitals. These exclusive contracts generally result in radiology departments and associated equipment being closed off to physicians who are not part of the contracting groups. Although exclusive contracts offer obvious benefits to the physicians who receive them and obvious disadvantages for those who are excluded, they also present pitfalls for physicians in the chosen group. Part 1 of this article discussed the legal issues raised by exclusive contracts. Part 2 weighs the practical advantages and disadvantages of exclusive contracts for physicians covered and not covered by such contracts and strategies for avoiding them, as well as provisions that can be included in medical staff bylaws to protect physicians from the automatic termination of privileges when a hospital enters into or terminates an exclusive contract. The remainder of the article provides tips on specific provisions of exclusive contracts that should be included or avoided.

48 CFR 1449.107 - Audit of prime contract settlement proposals and subcontract settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Audit of prime contract settlement proposals and subcontract settlements. 1449.107 Section 1449.107 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1449...

26 CFR 301.6043-1 - Returns regarding liquidation, dissolution, termination, or contraction.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Returns regarding liquidation, dissolution... and Returns Returns and Records § 301.6043-1 Returns regarding liquidation, dissolution, termination... liquidations, dissolutions, terminations, or contracts, see §§ l.6043-1, 1.6043-2, and 1.6043-3 of this chapter...

26 CFR 301.6043-1 - Returns regarding liquidation, dissolution, termination, or contraction.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Returns regarding liquidation, dissolution... and Returns Returns and Records § 301.6043-1 Returns regarding liquidation, dissolution, termination... liquidations, dissolutions, terminations, or contracts, see §§ l.6043-1, 1.6043-2, and 1.6043-3 of this chapter...

26 CFR 301.6043-1 - Returns regarding liquidation, dissolution, termination, or contraction.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Returns regarding liquidation, dissolution... and Returns Returns and Records § 301.6043-1 Returns regarding liquidation, dissolution, termination... liquidations, dissolutions, terminations, or contracts, see §§ l.6043-1, 1.6043-2, and 1.6043-3 of this chapter...

26 CFR 301.6043-1 - Returns regarding liquidation, dissolution, termination, or contraction.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Returns regarding liquidation, dissolution... and Returns Returns and Records § 301.6043-1 Returns regarding liquidation, dissolution, termination... liquidations, dissolutions, terminations, or contracts, see §§ l.6043-1, 1.6043-2, and 1.6043-3 of this chapter...

26 CFR 301.6043-1 - Returns regarding liquidation, dissolution, termination, or contraction.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Returns regarding liquidation, dissolution... and Returns Returns and Records § 301.6043-1 Returns regarding liquidation, dissolution, termination... liquidations, dissolutions, terminations, or contracts, see §§ l.6043-1, 1.6043-2, and 1.6043-3 of this chapter...

Contracts in radiology practices: contract types and key provisions.

PubMed

Muroff, Julie A; Muroff, Lawrence R

2004-07-01

A contract between a radiology group and its physician member(s) provides the foundation for the professional relationships in a group practice. The parties are not in positions of parity; contract provisions are structured to maintain the primacy of the group over the individual members. An integration clause should be included to preclude reliance on communications that are not memorialized by the language of the contract. Precise, unambiguous terms must be used to convey the intentions of the parties. The contract should have a clear date of initiation and, if applicable, an effective date of termination. Mechanisms for termination and modification should be expressed clearly to minimize the risk of judicial interference. The method of determining and adjusting the salary and other benefits of the radiologist should be stated, as consideration is necessary to support the existence of a legal contract. The obligations of the radiologist to the practice are often stated in general terms to maximize the group's flexibility. Finally, other key clauses that are discussed in the paper should be incorporated into the contract.

48 CFR 49.100 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 49.100 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.100 Scope of subpart. (a) This subpart deals with— (1) The...; and (4) Settlement agreements. (b) Additional principles applicable to the termination for convenience...

48 CFR 49.109-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false General. 49.109-1 Section 49.109-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-1 General. When a termination settlement has been...

48 CFR 49.603-5 - Cost-reimbursement contracts-partial termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost-reimbursement....603-5 Cost-reimbursement contracts—partial termination. [Insert the following in Block 14 of SF 30, Amendment of Solicitation/Modification of Contract, for settlement agreements for cost-reimbursement...

48 CFR 849.111-71 - Submission of information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 849.111-71 Submission of information. (a) The contracting officer shall submit to the appropriate Acquisition Program Management Division or... submission of additional information. (b) The Director, Acquisition Program Management Division, or the...

Intrinsic rhythm and basic tonus in insect skeletal muscle.

PubMed

Hoyle, G

1978-04-01

The jumping muscle of orthopterous insects contains fibres that possess an intrinsic rhythm (IR) of slow contraction. The contributing fibres are generally synchronized, but as many as three or four pacemakers are present. The frequency, amplitude and duration of IR contractions fluctuate erratically over a 24 h period. Metathoracic DUM neurone bursts suppress IR for a few minutes. Other, unidentified dorsal neurones enhance its amplitude. In addition to IR, the extensor tibiae shows intrinsic basic tonus (BT). BT is relaxed for several s by low-frequency burst output from unidentified metathoracic dorsal neurones. DUM neurone bursts may enhance extensor BT, relax it, or leave it unaffected. The effects on IR of various regimes of activity in the slow extensor tibiae (SETi) and the common inhibitor (CI) axons were examined. CI affects IR when stimulated at frequencies above 2 Hz. It causes amplitude depression and reduced duration of individual IR contractions as well as increased frequency. At 30 Hz and above, CI completely suppresses IR. An enhanced IR contraction starts within a few milliseconds of the termination of a CI train. At low frequencies (below 10 Hz) SETi causes increased frequency and decreased amplitude of IR, with a depressed IR contraction following cessation of the SETi burst. At frequencies above 15 Hz the SETi-evoked contraction dominates tension development, though IR summates with it during the rising phase. In quiescent preparations not showing IR, SETi stimulation at 10 Hz often started up IR. Single SETi or FETi impulses can initiate an IR contraction, and cause altered phasing, with up to a quintupling of frequency. After a critical period has elapsed following the onset of an IR contraction, a single single impulse in any one of the three axons will terminate it abruptly. The early termination is followed by a reduced interval which is proportional to the reduced IR contraction time. The rhythm of accumulated readiness to go into an IR contraction is independent of the pacemaker rhythm that initiates the contraction.

48 CFR 1652.249-72 - FEHBP termination for default-negotiated benefits contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false FEHBP termination for default-negotiated benefits contracts. 1652.249-72 Section 1652.249-72 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CLAUSES...

48 CFR 49.602-2 - Inventory forms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Inventory forms. 49.602-2... TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.602-2 Inventory forms. Standard Form (SF) 1428, Inventory Disposal Schedule, and SF 1429, Inventory Disposal Schedule—Continuation Sheet, shall...

41 CFR 101-6.213-7 - Post termination proceedings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Post termination proceedings. 101-6.213-7 Section 101-6.213-7 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 6-MISCELLANEOUS REGULATIONS 6.2...

48 CFR 49.607 - Delinquency notices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Delinquency notices. 49... MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.607 Delinquency notices. The formats of the delinquency notices in this section may be used to satisfy the requirements of 49.402-3...

48 CFR 49.303-3 - Audit of settlement proposal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Audit of settlement proposal. 49.303-3 Section 49.303-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts...

48 CFR 49.303-4 - Adjustment of indirect costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Adjustment of indirect costs. 49.303-4 Section 49.303-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts...

48 CFR 49.303-1 - Submission of settlement proposal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of settlement proposal. 49.303-1 Section 49.303-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement Contracts...

48 CFR 1.602-1 - Authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Authority. 1.602-1 Section... ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.602-1 Authority. (a) Contracting officers have authority to enter into, administer, or terminate contracts and...

7 CFR 1470.27 - Contract violations and termination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the participant's control prevented compliance with the contract. If a participant claims hardship... prevented compliance with the contract. If a participant claims hardship, that claim must be well documented... out its role in this section, NRCS may consult with the local conservation district. ...

48 CFR 1652.249-71 - FEHBP termination for convenience of the government-negotiated benefits contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false FEHBP termination for convenience of the government-negotiated benefits contracts. 1652.249-71 Section 1652.249-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION...

48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

48 CFR 423.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Suspension of payments, termination of contract, and debarment and suspension actions. 423.506 Section 423.506 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY...

36 CFR 223.46 - Adjustment of contract termination date.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Adjustment of contract termination date. 223.46 Section 223.46 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

36 CFR 223.46 - Adjustment of contract termination date.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Adjustment of contract termination date. 223.46 Section 223.46 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

36 CFR 223.46 - Adjustment of contract termination date.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Adjustment of contract termination date. 223.46 Section 223.46 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

75 FR 82576 - Federal Acquisition Regulation; Terminating Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... Acquisition Council (Councils) agree. The language at FAR 49.501, pertaining to the applicability of FAR part...-AL56 Federal Acquisition Regulation; Terminating Contracts AGENCY: Department of Defense (DoD), General.... SUMMARY: DoD, GSA, and NASA are issuing a final rule amending the Federal Acquisition Regulation (FAR) to...

48 CFR 49.115 - Settlement of terminated incentive contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Revision—Firm Target, and 52.249-2, Termination for Convenience of the Government (Fixed-Price). (1... Price Revision—Firm Target, or paragraph (1) of the clause at 52.216-17, Incentive Price Revision—Successive Targets. The contracting officer shall apply the incentive price revision provisions to completed...

48 CFR 52.249-7 - Termination (Fixed-Price Architect-Engineer).

Code of Federal Regulations, 2013 CFR

2013-10-01

... Architect-Engineer). 52.249-7 Section 52.249-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.249-7 Termination (Fixed-Price Architect-Engineer). As prescribed in 49.503(b), insert the following clause in solicitations and contracts for architect-engineer services when a fixed-price contract...

48 CFR 52.249-7 - Termination (Fixed-Price Architect-Engineer).

Code of Federal Regulations, 2011 CFR

2011-10-01

... Architect-Engineer). 52.249-7 Section 52.249-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.249-7 Termination (Fixed-Price Architect-Engineer). As prescribed in 49.503(b), insert the following clause in solicitations and contracts for architect-engineer services when a fixed-price contract...

48 CFR 52.249-7 - Termination (Fixed-Price Architect-Engineer).

Code of Federal Regulations, 2014 CFR

2014-10-01

... Architect-Engineer). 52.249-7 Section 52.249-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.249-7 Termination (Fixed-Price Architect-Engineer). As prescribed in 49.503(b), insert the following clause in solicitations and contracts for architect-engineer services when a fixed-price contract...

48 CFR 52.249-7 - Termination (Fixed-Price Architect-Engineer).

Code of Federal Regulations, 2012 CFR

2012-10-01

... Architect-Engineer). 52.249-7 Section 52.249-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.249-7 Termination (Fixed-Price Architect-Engineer). As prescribed in 49.503(b), insert the following clause in solicitations and contracts for architect-engineer services when a fixed-price contract...

24 CFR 266.608 - Mortgage insurance premium: Pro rata refund.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage insurance premium: Pro... PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.608 Mortgage insurance premium: Pro rata refund. If the Contract of Insurance is terminated by payment in full or is terminated...

24 CFR 266.608 - Mortgage insurance premium: Pro rata refund.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Mortgage insurance premium: Pro... PROJECT LOANS Contract Rights and Obligations Mortgage Insurance Premiums § 266.608 Mortgage insurance premium: Pro rata refund. If the Contract of Insurance is terminated by payment in full or is terminated...

48 CFR 49.402-1 - The Government's right.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false The Government's right. 49... MANAGEMENT TERMINATION OF CONTRACTS Termination for Default 49.402-1 The Government's right. Under contracts containing the Default clause at 52.249-8, the Government has the right, subject to the notice requirements...

36 CFR 223.46 - Adjustment of contract termination date.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 36 Parks, Forests, and Public Property 2 2011-07-01 2011-07-01 false Adjustment of contract termination date. 223.46 Section 223.46 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

48 CFR 49.402-1 - The Government's right.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false The Government's right. 49... MANAGEMENT TERMINATION OF CONTRACTS Termination for Default 49.402-1 The Government's right. Under contracts containing the Default clause at 52.249-8, the Government has the right, subject to the notice requirements...

76 FR 53719 - Nondisplacement of Qualified Workers Under Service Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-29

...In this final rule, the Department of Labor (Department or DOL) issues final regulations to implement Executive Order 13495, Nondisplacement of Qualified Workers Under Service Contracts. The Executive Order establishes a general policy of the Federal Government concerning service contracts and solicitations for service contracts for performance of the same or similar services at the same location. This policy mandates the inclusion of a contract clause requiring the successor contractor and its subcontractors to offer those employees employed under the predecessor contract, whose employment will be otherwise terminated as a result of the award of the successor contract, a right of first refusal of employment under the successor contract in positions for which they are qualified.

48 CFR 49.206-3 - Submission of inventory disposal schedules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of inventory disposal schedules. 49.206-3 Section 49.206-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Fixed-Price Contracts...

17 CFR 3.46 - Termination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... conducted pursuant to the rules of a designated contract market, registered derivatives transaction... a contract market, registered derivatives transaction execution facility, or other appropriate...

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2013 CFR

2013-04-01

... payments are to be made, the value may be approximated by adding to the interpolated terminal reserve at... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX... and annuity contracts. The value of a life insurance contract or of a contract for the payment of an...

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2012 CFR

2012-04-01

... payments are to be made, the value may be approximated by adding to the interpolated terminal reserve at... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX... and annuity contracts. The value of a life insurance contract or of a contract for the payment of an...

26 CFR 25.2512-6 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2014 CFR

2014-04-01

... payments are to be made, the value may be approximated by adding to the interpolated terminal reserve at... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GIFT TAX... and annuity contracts. The value of a life insurance contract or of a contract for the payment of an...

48 CFR 49.112-1 - Partial payments.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Partial payments. 49.112-1 Section 49.112-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.112-1 Partial payments. (a) General. If the contract authorizes...

48 CFR 849.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 849.106 Fraud or other criminal conduct. (a... following: (i) The DSPE. (ii) The Director, Office of Construction and Facilities Management, in the case of contracting officers from the Office of Construction and Facilities Management. (3) Follow procedures as...

48 CFR 923.570-3 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS ENVIRONMENT, CONSERVATION, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 923.570-3 Suspension of payments, termination of contract... make a good faith effort to provide a drug free workplace. [57 FR 32676, July 22, 1992, as amended at...

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Part D plan in writing 90 days before the intended date of the termination. (ii) The Part D plan... sponsor; (B) The Part D plan sponsor experiences financial difficulties so severe that its ability to make...)(4) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

42 CFR 423.509 - Termination of contract by CMS.

Code of Federal Regulations, 2013 CFR

2013-10-01

... plan in writing 90 days before the intended date of the termination. (ii) The Part D plan sponsor... sponsor; (B) The Part D plan sponsor experiences financial difficulties so severe that its ability to make...)(4) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

24 CFR 232.825 - Pro rata refund of insurance premium.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ASSISTED LIVING FACILITIES Contract Rights and Obligations Premiums § 232.825 Pro rata refund of insurance premium. Upon termination of a loan insurance contract by a payment in full or by a voluntary termination... rata portion of the current annual loan insurance premium theretofore paid which is applicable to the...

24 CFR 232.825 - Pro rata refund of insurance premium.

Code of Federal Regulations, 2011 CFR

2011-04-01

... ASSISTED LIVING FACILITIES Contract Rights and Obligations Premiums § 232.825 Pro rata refund of insurance premium. Upon termination of a loan insurance contract by a payment in full or by a voluntary termination... rata portion of the current annual loan insurance premium theretofore paid which is applicable to the...

42 CFR 417.464 - End of CMS's liability for payment: Disenrollment of beneficiaries and termination or default of...

Code of Federal Regulations, 2010 CFR

2010-10-01

... of beneficiaries and termination or default of contract. 417.464 Section 417.464 Public Health... PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE PREPAYMENT PLANS Enrollment, Entitlement, and Disenrollment under Medicare Contract § 417.464 End of CMS's liability for...

5 CFR 890.205 - Nonrenewal of contracts of health benefits plans.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Health Benefits Plans § 890.205 Nonrenewal of contracts of health benefits plans. (a) Either OPM or the carrier may terminate... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Nonrenewal of contracts of health...

5 CFR 890.205 - Nonrenewal of contracts of health benefits plans.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Health Benefits Plans § 890.205 Nonrenewal of contracts of health benefits plans. (a) Either OPM or the carrier may terminate... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Nonrenewal of contracts of health...

48 CFR 904.7004 - Findings, determination, and contract award or termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... that award of a contract to an offeror(s) or continued performance of a contract by a contractor will... types of plans that a contractor can propose are: measures which provide for physical or organizational separation of the facility or organizational component containing the classified information or special...

23 CFR 635.125 - Termination of contract.

Code of Federal Regulations, 2010 CFR

2010-04-01

... shall Federal funds participate in anticipated profit on work not performed. (c) Except as provided for..., advertising, and award procedures are to be followed when a STD awards the contract for completion of a... the original contract to be in effect and that the work will be completed in accordance with the...

Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic?

PubMed

Kim, Tae Ho; Patel, Nirali; Ledgerwood-Lee, Melissa; Mittal, Ravinder K

2016-05-01

Absence of peristalsis and impaired relaxation of lower esophageal sphincter are the hallmarks of achalasia esophagus. Based on the pressurization patterns, achalasia has been subdivided into three subtypes. The goal of our study was to evaluate the esophageal contraction pattern and bolus clearance in type 3 achalasia esophagus. High-resolution manometry (HRM) recordings of all patients diagnosed with achalasia esophagus in our center between the years 2011 and 2013 were reviewed. Recordings of 36 patients with type 3 achalasia were analyzed for the characteristics of swallow-induced "simultaneous esophageal contraction." The HRM impedance recordings of 14 additional patients with type 3 achalasia were analyzed for bolus clearance from the impedance recording. Finally, the HRM impedance along with intraluminal ultrasound imaging was conducted in six patients to further characterize the simultaneous esophageal contractions. Among 187 achalasia patients, 30 were type 1, 121 type 2, and 36 type 3. A total of 434 swallows evaluated in type 3 achalasia patients revealed that 95% of the swallow-induced contractions met criteria for simultaneous esophageal contraction, based on the onset of contraction. Interestingly, the peak and termination of the majority of simultaneous esophageal contractions were sequential. The HRM impedance revealed that 94% of the "simultaneous contractions" were associated with complete bolus clearance. Ultrasound image analysis revealed that baseline muscle thickness of patients in type 3 achalasia is larger than normal but the pattern of axial shortening is similar to that in normal subjects. The majority of esophageal contractions in type 3 achalasia are not true simultaneous contractions because the peak and termination of contraction are sequential and they are associated with complete bolus clearance.

48 CFR 1823.570-3 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 1823.570-3 Suspension of payments, termination of contract, and debarment and... provide a drug- and alcohol-free workforce. [61 FR 55757, Oct. 29, 1996. Redesignated and amended at 69 FR...

48 CFR 1823.570-3 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 1823.570-3 Suspension of payments, termination of contract, and debarment and... provide a drug- and alcohol-free workforce. [61 FR 55757, Oct. 29, 1996. Redesignated and amended at 69 FR...

48 CFR 1823.570-3 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 1823.570-3 Suspension of payments, termination of contract, and debarment and... provide a drug- and alcohol-free workforce. [61 FR 55757, Oct. 29, 1996. Redesignated and amended at 69 FR...

48 CFR 1823.570-3 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 1823.570-3 Suspension of payments, termination of contract, and debarment and... provide a drug- and alcohol-free workforce. [61 FR 55757, Oct. 29, 1996. Redesignated and amended at 69 FR...

48 CFR 1823.570-3 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 1823.570-3 Suspension of payments, termination of contract, and debarment and... provide a drug- and alcohol-free workforce. [61 FR 55757, Oct. 29, 1996. Redesignated and amended at 69 FR...

48 CFR 49.603-4 - Cost-reimbursement contracts-complete termination, with settlement limited to fee.

Code of Federal Regulations, 2010 CFR

2010-10-01

... settlement limited to fee. [Insert the following in Block 14 of SF 30 for settlement of cost-reimbursement... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost-reimbursement contracts-complete termination, with settlement limited to fee. 49.603-4 Section 49.603-4 Federal...

49 CFR 23.39 - What other certification requirements apply in the case of ACDBEs?

Code of Federal Regulations, 2010 CFR

2010-10-01

... the firm and its key personnel to perform the concession contracts or other contracts it wishes to... private terminal owners or lessees are not authorized to certify firms as ACDBEs. As a car rental company or private terminal owner or lessee, you must obtain ACDBE participation from firms which a recipient...

49 CFR 23.39 - What other certification requirements apply in the case of ACDBEs?

Code of Federal Regulations, 2012 CFR

2012-10-01

... the firm and its key personnel to perform the concession contracts or other contracts it wishes to... private terminal owners or lessees are not authorized to certify firms as ACDBEs. As a car rental company or private terminal owner or lessee, you must obtain ACDBE participation from firms which a recipient...

49 CFR 23.39 - What other certification requirements apply in the case of ACDBEs?

Code of Federal Regulations, 2011 CFR

2011-10-01

... the firm and its key personnel to perform the concession contracts or other contracts it wishes to... private terminal owners or lessees are not authorized to certify firms as ACDBEs. As a car rental company or private terminal owner or lessee, you must obtain ACDBE participation from firms which a recipient...

49 CFR 23.39 - What other certification requirements apply in the case of ACDBEs?

Code of Federal Regulations, 2013 CFR

2013-10-01

... the firm and its key personnel to perform the concession contracts or other contracts it wishes to... private terminal owners or lessees are not authorized to certify firms as ACDBEs. As a car rental company or private terminal owner or lessee, you must obtain ACDBE participation from firms which a recipient...

49 CFR 23.39 - What other certification requirements apply in the case of ACDBEs?

Code of Federal Regulations, 2014 CFR

2014-10-01

... the firm and its key personnel to perform the concession contracts or other contracts it wishes to... private terminal owners or lessees are not authorized to certify firms as ACDBEs. As a car rental company or private terminal owner or lessee, you must obtain ACDBE participation from firms which a recipient...

7 CFR 1468.21 - Contract requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... provisions of § 1468.24 of this part; (iv) Agree to forego participation in CRP, EQIP, and the cost-share... those practices transferred from terminated CRP and EQIP contracts and WRP cost-share agreements. For persons wishing to transfer from CRP, EQIP, or WRP to CFO, practices included in CRP or EQIP contracts or...

48 CFR 41.205 - Separate contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... following information: (1) The number of available suppliers. (2) Any special equipment, service reliability... termination liability. (4) Total estimated contract value (including costs in subparagraphs (b) (2) and (3) of...

Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic?

PubMed Central

Kim, Tae Ho; Patel, Nirali; Ledgerwood-Lee, Melissa

2016-01-01

Absence of peristalsis and impaired relaxation of lower esophageal sphincter are the hallmarks of achalasia esophagus. Based on the pressurization patterns, achalasia has been subdivided into three subtypes. The goal of our study was to evaluate the esophageal contraction pattern and bolus clearance in type 3 achalasia esophagus. High-resolution manometry (HRM) recordings of all patients diagnosed with achalasia esophagus in our center between the years 2011 and 2013 were reviewed. Recordings of 36 patients with type 3 achalasia were analyzed for the characteristics of swallow-induced “simultaneous esophageal contraction.” The HRM impedance recordings of 14 additional patients with type 3 achalasia were analyzed for bolus clearance from the impedance recording. Finally, the HRM impedance along with intraluminal ultrasound imaging was conducted in six patients to further characterize the simultaneous esophageal contractions. Among 187 achalasia patients, 30 were type 1, 121 type 2, and 36 type 3. A total of 434 swallows evaluated in type 3 achalasia patients revealed that 95% of the swallow-induced contractions met criteria for simultaneous esophageal contraction, based on the onset of contraction. Interestingly, the peak and termination of the majority of simultaneous esophageal contractions were sequential. The HRM impedance revealed that 94% of the “simultaneous contractions” were associated with complete bolus clearance. Ultrasound image analysis revealed that baseline muscle thickness of patients in type 3 achalasia is larger than normal but the pattern of axial shortening is similar to that in normal subjects. The majority of esophageal contractions in type 3 achalasia are not true simultaneous contractions because the peak and termination of contraction are sequential and they are associated with complete bolus clearance. PMID:26950858

Automatic Conflict Detection on Contracts

NASA Astrophysics Data System (ADS)

Fenech, Stephen; Pace, Gordon J.; Schneider, Gerardo

Many software applications are based on collaborating, yet competing, agents or virtual organisations exchanging services. Contracts, expressing obligations, permissions and prohibitions of the different actors, can be used to protect the interests of the organisations engaged in such service exchange. However, the potentially dynamic composition of services with different contracts, and the combination of service contracts with local contracts can give rise to unexpected conflicts, exposing the need for automatic techniques for contract analysis. In this paper we look at automatic analysis techniques for contracts written in the contract language mathcal{CL}. We present a trace semantics of mathcal{CL} suitable for conflict analysis, and a decision procedure for detecting conflicts (together with its proof of soundness, completeness and termination). We also discuss its implementation and look into the applications of the contract analysis approach we present. These techniques are applied to a small case study of an airline check-in desk.

42 CFR 423.510 - Termination of contract by the Part D sponsor.

Code of Federal Regulations, 2011 CFR

2011-10-01

... member of the board of directors or board of trustees of the entity, if the organization is organized as a corporation. (f) Timely transfer of data and files. If a contract is terminated under paragraph (a) of this section, the Part D plan sponsor must ensure the timely transfer of any data or files. [70 FR...

42 CFR 423.510 - Termination of contract by the Part D sponsor.

Code of Federal Regulations, 2013 CFR

2013-10-01

... member of the board of directors or board of trustees of the entity, if the organization is organized as a corporation. (f) Timely transfer of data and files. If a contract is terminated under paragraph (a) of this section, the Part D plan sponsor must ensure the timely transfer of any data or files. [70 FR...

Collagen telopeptides (cross-linking sites) play a role in collagen gel lattice contraction

NASA Technical Reports Server (NTRS)

Woodley, D. T.; Yamauchi, M.; Wynn, K. C.; Mechanic, G.; Briggaman, R. A.

1991-01-01

Solubilized interstitial collagens will form a fibrillar, gel-like lattice when brought to physiologic conditions. In the presence of human dermal fibroblasts the collagen lattice will contract. The rate of contraction can be determined by computer-assisted planemetry. The mechanisms involved in contraction are as yet unknown. Using this system it was found that the rate of contraction was markedly decreased when collagen lacking telopeptides was substituted for native collagen. Histidinohydroxylysinonorleucine (HHL) is a major stable trifunctional collagen cross-link in mature skin that involves a carboxyl terminal, telopeptide site 16c, the sixteenth amino acid residue from the carboxy terminal of the telopeptide region of alpha 1 (I) in type I collagen. Little, if any, HHL was present in native, purified, reconstituted, soluble collagen fibrils from 1% acetic acid-extracted 2-year-old bovine skin. In contrast, HHL cross-links were present (0.22 moles of cross-link per mole of collagen) in lattices of the same collagen contracted by fibroblasts. However, rat tail tendon does not contain HHL cross-links, and collagen lattices made of rat tail tendon collagen are capable of contraction. This suggests that telopeptide sites, and not mature HHL cross-links per se, are essential for fibroblasts to contract collagen lattices. Beta-aminopropionitrile fumarate (BAPN), a potent lathyrogen that perturbs collagen cross-linking by inhibition of lysyl oxidase, also inhibited the rate of lattice cell contraction in lattices composed of native collagen. However, the concentrations of BAPN that were necessary to inhibit the contraction of collagen lattices also inhibited fibroblast growth suggestive of cellular toxicity. In accordance with other studies, we found no inhibition of the rate of lattice contraction when fibronectin-depleted serum was used. Electron microscopy of contracted gels revealed typical collagen fibers with a characteristic axial periodicity. The data provide evidence that collagen telopeptide sites play a role in collagen gel lattice contraction.

48 CFR 1649.101-70 - FEHBP renewal and withdrawal of approval clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1649.101-70 FEHBP renewal and withdrawal of approval clause. The...

48 CFR 49.108-4 - Authorization for subcontract settlements without approval or ratification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-4 Authorization for subcontract settlements without approval or ratification. (a)(1) The...

48 CFR 49.112 - Payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Payment. 49.112 Section 49.112 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.112 Payment. ...

48 CFR 49.504 - Termination of fixed-price contracts for default.

Code of Federal Regulations, 2010 CFR

2010-10-01

... simplified acquisition threshold, if appropriate (e.g., if the acquisition involves items with a history of unsatisfactory quality). (2) Transportation. If the contract is for transportation or transportation-related...

7 CFR 1465.25 - Contract violations and termination.

Code of Federal Regulations, 2010 CFR

2010-01-01

... prevented compliance with the contract. If the participant claims hardship, that claim must be well... is in the public interest. (iii) In carrying out NRCS' role in this section, NRCS may consult with...

26 CFR 20.2031-8 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2012 CFR

2012-04-01

..., the value may be approximated by adding to the interpolated terminal reserve at the date of the... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES ESTATE TAX... certain life insurance and annuity contracts. (1) The value of a contract for the payment of an annuity...

26 CFR 20.2031-8 - Valuation of certain life insurance and annuity contracts; valuation of shares in an open-end...

Code of Federal Regulations, 2013 CFR

2013-04-01

..., the value may be approximated by adding to the interpolated terminal reserve at the date of the... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES ESTATE TAX... certain life insurance and annuity contracts. (1) The value of a contract for the payment of an annuity...

Effect of endogenous tachykinins on neuro-effector transmission of vagal nerve in guinea-pig tracheal tissue.

PubMed

Aizawa, H; Miyazaki, N; Inoue, H; Ikeda, T; Shigematsu, N

1990-01-01

To elucidate the effect of endogenous tachykinins on neuro-effector transmission of vagal nerves, we performed in vitro experiments using guinea-pig tracheal smooth muscle. The subthreshold dose (the highest dose which did not induce any smooth muscle contraction) of capsaicin (10(-8) to 10(-7) M) increased the amplitudes of contractions evoked by electrical field stimulation (EFS) significantly, but not those by acetylcholine (ACh). The inhibitor of neutral endopeptidase, phosphoramidon (10(-7) to 10(-6) M), increased the contractions evoked by EFS significantly. The inhibitor of cholinesterase, physostigmine (10(-6) to 10(-5) M), induced smooth muscle contractions, but such contractions were inhibited by atropine, suggesting the spontaneous release of ACh from the vagal nerve terminals. The subthreshold dose of substance P or capsaicin increased the contractions evoked by physostigmine. These results indicated that endogenous tachykinins increase the spontaneous ACh release as well as the ACh release in response to vagal stimulation from the nerve terminals. Furthermore, it is suggested that the excitatory effects of the tachykinins on the vagal neuro-effector transmission may be modulated by neutral endopeptidase in the guinea pig.

Personhood and Moral Status of The Embryo: It's Effect on Validity of Surrogacy Contract Revocation according to Shia Jurisprudence Perspective.

PubMed

Nazari Tavakkoli, Saeid

2017-10-01

One of the most controversial issues related to the human embryo is the determination of the moment when an embryo is considered a human being and acquires a moral status. Although personhood and moral status are frequently mentioned in medical ethics, they are considered interdisciplinary as concepts that shape the debate in medical law (fiqh) since their consequences are influential in the way which the parents and other individuals behave towards the embryo. This analytical-descriptive research gathered relevant data in a literature search. After a description of the fundamentals and definitions, we subsequently analyzed juridical texts and selected one of the viewpoints that regarded the surrogacy contract revocation. The surrogacy contract is a contract based upon which two sides (infertile couple and surrogate mother) involved in making the contract are obligated to fulfill its terms. Therefore, contract revocation can be surveyed from three perspectives: mutual revocation (iqala), legal unilateral wills (khiar al-majlis, khiar al-ayb), and contractual wills (khiar al-shart). Revocation of a surrogacy contract either by the genetic parents, surrogate or the fertility clinic is allowed by Muslim jurists only when the embryo lacks personhood. Based on Islamic teachings, the termination of a surrogacy contract in and after the sixteenth week of pregnancy, when the embryo acquires a human soul (ensoulment), is not allowed. However religious thought emphasizes the moral status of the fetus before the sixteenth week and states that optional termination of the surrogacy contract is not permitted while the fetus becomes a human being. Copyright© by Royan Institute. All rights reserved.

48 CFR 47.301-3 - Using the Defense Transportation System (DTS).

Code of Federal Regulations, 2010 CFR

2010-10-01

... implemented on a world-wide basis. (b) Contracting activities are responsible for (1) ensuring that the... directly to a military air or water port terminal without authorization from the designated contract...

24 CFR 882.516 - Maintenance, operation and inspections.

Code of Federal Regulations, 2011 CFR

2011-04-01

... compliance with the terms and conditions of the Contract and the ACC. Should HUD determine that there are... HUD in the ACC, require termination of the management contract, or take other appropriate action. (e...

24 CFR 882.516 - Maintenance, operation and inspections.

Code of Federal Regulations, 2010 CFR

2010-04-01

... compliance with the terms and conditions of the Contract and the ACC. Should HUD determine that there are... HUD in the ACC, require termination of the management contract, or take other appropriate action. (e...

46 CFR 295.20 - General conditions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ODS contract under subtitle A, title VI, of the act or on charter to the U.S. Government, other than a... Agreement shall be: (i) The expiration or termination date of the ODS contract or Government charter...

Doctor group sues to keep capitation arrangement.

PubMed

2005-05-01

An independent practice association has sued Humana Kansas City Inc. over the health plan's decision to terminate its capitated contract. The suit alleges breach of contract and seeks an injunction to keep the flow of capitated dollars coming.

48 CFR 49.109 - Settlement agreements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Settlement agreements. 49.109 Section 49.109 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109 Settlement agreements. ...

48 CFR 49.109 - Settlement agreements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Settlement agreements. 49.109 Section 49.109 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109 Settlement agreements. ...

48 CFR 49.109 - Settlement agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Settlement agreements. 49.109 Section 49.109 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109 Settlement agreements. ...

24 CFR 206.103 - Payment of MIP.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums § 206.103 Payment... cash, until the contract of insurance is terminated. ...

24 CFR 206.103 - Payment of MIP.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums § 206.103 Payment... cash, until the contract of insurance is terminated. ...

Smart Shutdown Guidebook: Considerations for a Successful Shutdown

DTIC Science & Technology

2014-01-01

multiple countries, multiple contractors) or in number of subsystems and interfaces • State of the contract (is the procuring contract officer ( PCO ...assigned tasks. • Includes the procuring, administrative, and terminating contracting officers ( PCOs , ACOs, and TCOs). 6 • Assigns full authority and...assist the PCO and TCO with their correspondence requirements with contractors and to assist higher leadership in its communication with external

48 CFR 249.109 - Settlement agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Settlement agreements. 249.109 Section 249.109 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 249.109 Settlement...

7 CFR 1466.26 - Contract violations and terminations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... a contract whereby a producer is receiving payments for conservation practices related to organic production, if the designated conservationist determines that the producer is not pursuing organic certification, or has been decertified. [74 FR 2313, Jan. 15, 2009] ...

48 CFR 49.303 - Procedure after discontinuing vouchers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedure after discontinuing vouchers. 49.303 Section 49.303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement...

48 CFR 49.110 - Settlement negotiation memorandum.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Settlement negotiation memorandum. 49.110 Section 49.110 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.110 Settlement negotiation memorandum...

Personhood and Moral Status of The Embryo: It’s Effect on Validity of Surrogacy Contract Revocation according to Shia Jurisprudence Perspective

PubMed Central

Tavakkoli, Saeid Nazari

2017-01-01

Background One of the most controversial issues related to the human embryo is the determination of the moment when an embryo is considered a human being and acquires a moral status. Although personhood and moral status are frequently mentioned in medical ethics, they are considered interdisciplinary as concepts that shape the debate in medical law (fiqh) since their consequences are influential in the way which the parents and other individuals behave towards the embryo. Materials and Methods This analytical-descriptive research gathered relevant data in a literature search. After a description of the fundamentals and definitions, we subsequently analyzed juridical texts and selected one of the viewpoints that regarded the surrogacy contract revocation. Results The surrogacy contract is a contract based upon which two sides (infertile couple and surrogate mother) involved in making the contract are obligated to fulfill its terms. Therefore, contract revocation can be surveyed from three perspectives: mutual revocation (iqala), legal unilateral wills (khiar al-majlis, khiar al-ayb), and contractual wills (khiar al-shart). Conclusion Revocation of a surrogacy contract either by the genetic parents, surrogate or the fertility clinic is allowed by Muslim jurists only when the embryo lacks personhood. Based on Islamic teachings, the termination of a surrogacy contract in and after the sixteenth week of pregnancy, when the embryo acquires a human soul (ensoulment), is not allowed. However religious thought emphasizes the moral status of the fetus before the sixteenth week and states that optional termination of the surrogacy contract is not permitted while the fetus becomes a human being. PMID:28868846

48 CFR 49.110 - Settlement negotiation memorandum.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Settlement negotiation... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.110 Settlement negotiation memorandum. (a) The TCO shall, at the conclusion of negotiations, prepare a settlement negotiation memorandum...

48 CFR 49.110 - Settlement negotiation memorandum.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Settlement negotiation... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.110 Settlement negotiation memorandum. (a) The TCO shall, at the conclusion of negotiations, prepare a settlement negotiation memorandum...

48 CFR 49.110 - Settlement negotiation memorandum.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Settlement negotiation... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.110 Settlement negotiation memorandum. (a) The TCO shall, at the conclusion of negotiations, prepare a settlement negotiation memorandum...

48 CFR 49.110 - Settlement negotiation memorandum.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Settlement negotiation... CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.110 Settlement negotiation memorandum. (a) The TCO shall, at the conclusion of negotiations, prepare a settlement negotiation memorandum...

48 CFR 49.101 - Authorities and responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Authorities and responsibilities. 49.101 Section 49.101 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.101 Authorities and responsibilities. (a...

48 CFR 849.101 - Authorities and responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Authorities and responsibilities. 849.101 Section 849.101 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 849.101 Authorities and responsibilities...

48 CFR 949.101 - Authorities and responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Authorities and responsibilities. 949.101 Section 949.101 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 949.101 Authorities and responsibilities. The Senior...

48 CFR 239.7411 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Telecommunications..., Charges, and Services; (4) 252.239-7006, Tariff Information; (5) 252.239-7007, Cancellation or Termination..., Continuation of Communication Service Authorizations, as appropriate, and insert in paragraph (a) of the clause...

41 CFR 60-30.30 - Final Administrative Order.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requiring the contractor to provide whatever remedies are appropriate, and imposing whatever sanctions are... in the immediate cancellation, termination and suspension of the respondent's contracts and/or debarment of the respondent from further contracts. [61 FR 19988, May 3, 1996] Expedited Hearing Procedures...

48 CFR 49.111 - Review of proposed settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Review of proposed settlements. 49.111 Section 49.111 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.111 Review of proposed settlements. Each...

48 CFR 49.108-1 - Subcontractor's rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontractor's rights. 49.108-1 Section 49.108-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-1 Subcontractor's rights. A subcontractor has...

48 CFR 49.113 - Cost principles.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cost principles. 49.113 Section 49.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.113 Cost principles. The cost principles and procedures in the...

48 CFR 849.111 - Review of proposed settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Review of proposed settlements. 849.111 Section 849.111 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 849.111 Review of proposed settlements. ...

48 CFR 749.111 - Review of proposed settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Review of proposed settlements. 749.111 Section 749.111 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.111 Review of proposed...

48 CFR 449.111 - Review of proposed settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Review of proposed settlements. 449.111 Section 449.111 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 449.111 Review of proposed settlements. Proposed...

48 CFR 1449.111 - Review of proposed settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Review of proposed settlements. 1449.111 Section 1449.111 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1449.111 Review of proposed settlements...

48 CFR 49.108 - Settlement of subcontract settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Settlement of subcontract settlement proposals. 49.108 Section 49.108 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108 Settlement of subcontract...

48 CFR 970.5245-1 - Property.

Code of Federal Regulations, 2010 CFR

2010-10-01

... termination of this contract, the Contractor shall render an accounting, as prescribed by the Contracting... handling, control and disposition of high-risk property and classified materials throughout the life cycle... establish, administer, and properly maintain an approved property management system of accounting for and...

48 CFR 749.111 - Review of proposed settlements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Review of proposed settlements. 749.111 Section 749.111 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.111 Review of proposed...

17 CFR 3.42 - Termination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... period specified in the rules of a contract market, registered derivatives transaction execution facility... markets which filed the certification described in § 3.40; (3) Immediately upon the withdrawal of the... award in an arbitration proceeding conducted pursuant to the rules of a designated contract market...

ORGANIZATIONAL CONFLICT OF INTEREST AND THE AIR FORCE CONTRACT AUGMENTATION PROGRAM: A PATTERNED APPROACH TO RISK IDENTIFICATION

DTIC Science & Technology

2016-04-22

eight contractors. It is a multiple - award indefinite-delivery, indefinite quantity (IDIQ) $5 billion arrangement with one base year and four option...evaluation factors, and the pre-award phase is completed. The post-award phase concerns the insurance of performance under the terms of the contract...may have consequences ranging from award fee decrements , contract termination, suspension or debarment, or other appropriate remedies or

Contracts in radiology practices: breaches and remedies.

PubMed

Muroff, Julie A; Muroff, Lawrence R

2004-08-01

Contracts between radiology groups and their physician members are often ambiguous. Key clauses may not be precise as to the intent of the contracting parties. For example, the requirements for a group member to achieve shareholder status may be discussed but not reduced to a written form. Other contract provisions, such as termination or noncompete clauses, may be subject to different interpretations. The ambiguities of these provisions often generate disparate expectations regarding the parties' obligations to one another. When this occurs, the results may vary from disappointment to litigation. This paper discusses the causes and consequences of common breaches of radiology contracts. The types of remedies that may be available to the parties of the contract are also enumerated, and case law is cited to illustrate the challenges that radiology groups and their members may encounter. Finally, alternative forms of dispute resolution are discussed.

48 CFR 749.100 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 749.100 Section 749.100 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.100 Scope of subpart. The Foreign Aid and Related...

48 CFR 49.112-2 - Final payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Final payment. 49.112-2 Section 49.112-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.112-2 Final payment. (a) Negotiated settlement. After execution...

48 CFR 949.111 - Review of proposed settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Review of proposed settlements. 949.111 Section 949.111 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 949.111 Review of proposed settlements. (a) The Heads...

48 CFR 49.109-5 - Partial settlements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Partial settlements. 49.109-5 Section 49.109-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-5 Partial settlements. The TCO should attempt...

48 CFR 49.109-3 - Government property.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government property. 49.109-3 Section 49.109-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-3 Government property. Before execution of a...

48 CFR 49.109-2 - Reservations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Reservations. 49.109-2 Section 49.109-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-2 Reservations. (a) The TCO shall— (1) Reserve in the...

48 CFR 49.303-2 - Submission of inventory disposal schedules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of inventory disposal schedules. 49.303-2 Section 49.303-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement...

24 CFR 203.267 - Duration of periodic MIP.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic... deed to the Commissioner is filed for record or the contract of insurance is terminated. [48 FR 28805...

24 CFR 203.267 - Duration of periodic MIP.

Code of Federal Regulations, 2011 CFR

2011-04-01

... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic... deed to the Commissioner is filed for record or the contract of insurance is terminated. [48 FR 28805...

42 CFR 417.406 - Application and determination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... (CONTINUED) MEDICARE PROGRAM HEALTH MAINTENANCE ORGANIZATIONS, COMPETITIVE MEDICAL PLANS, AND HEALTH CARE PREPAYMENT PLANS Qualifying Conditions for Medicare Contracts § 417.406 Application and determination. (a... forth in § 417.407. (2) If an entity no longer meets those requirements, CMS terminates the contract of...

The Military Construction (MILCON) Program and Privatization: A Comparative Analysis

DTIC Science & Technology

1990-09-01

Government Contract Law , 1988: 13-4). The Davis-Bacon Act is implemented by Federal Acquisition Regulation (FAR) 22.400 and mandates that five provisions be...wages as determined by the Secretary of Labor (Dept. of the AF: Government Contract Law , 1988:13- 4). The Department of Labor wage determinations...Posting 4 - Withholding Payments 5 - Termination for Default 26 (Dept. of the AF: Government Contract Law , 1988: 13-4, 13-5) The residential schedule rates

c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis

DTIC Science & Technology

2013-10-01

Treatment of Amyotrophic Lateral Sclerosis ” PRINCIPAL INVESTIGATOR: Dr. Philip LoGrasso CONTRACTING ORGANIZATION: The Scripps Research... Lateral Sclerosis ” 5a. CONTRACT NUMBER W81XWH-12-1-0431 5b. GRANT NUMBER W81XWH-12-1-0431 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Philip...Annual 3. DATES COVERED 30September2012-29September2013 4. TITLE AND SUBTITLE “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic

4 CFR 21.8 - Remedies.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 4 Accounts 1 2011-01-01 2011-01-01 false Remedies. 21.8 Section 21.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES BID PROTEST REGULATIONS § 21.8 Remedies. (a) If GAO determines that a... following remedies: (1) Refrain from exercising options under the contract; (2) Terminate the contract; (3...

4 CFR 21.8 - Remedies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Remedies. 21.8 Section 21.8 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES BID PROTEST REGULATIONS § 21.8 Remedies. (a) If GAO determines that a... following remedies: (1) Refrain from exercising options under the contract; (2) Terminate the contract; (3...

48 CFR 49.000 - Scope of part.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Scope of part. 49.000 Section 49.000 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS 49.000 Scope of part. This part establishes policies and procedures relating to the...

48 CFR 49.000 - Scope of part.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Scope of part. 49.000 Section 49.000 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS 49.000 Scope of part. This part establishes policies and procedures relating to the...

48 CFR 49.000 - Scope of part.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Scope of part. 49.000 Section 49.000 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS 49.000 Scope of part. This part establishes policies and procedures relating to the...

48 CFR 49.206-2 - Bases for settlement proposals.

Code of Federal Regulations, 2013 CFR

2013-10-01

... construction or related professional services contract. (ii) The partial or complete termination of supply... distinguished from a lump-sum) professional services contract. (b) Total cost basis. (1) When use of the..., under the contractor's accounting system, unit costs for work in process and finished products cannot...

48 CFR 49.206-2 - Bases for settlement proposals.

Code of Federal Regulations, 2014 CFR

2014-10-01

... construction or related professional services contract. (ii) The partial or complete termination of supply... distinguished from a lump-sum) professional services contract. (b) Total cost basis. (1) When use of the..., under the contractor's accounting system, unit costs for work in process and finished products cannot...

48 CFR 49.206-2 - Bases for settlement proposals.

Code of Federal Regulations, 2012 CFR

2012-10-01

... construction or related professional services contract. (ii) The partial or complete termination of supply... distinguished from a lump-sum) professional services contract. (b) Total cost basis. (1) When use of the..., under the contractor's accounting system, unit costs for work in process and finished products cannot...

48 CFR 49.206-2 - Bases for settlement proposals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... construction or related professional services contract. (ii) The partial or complete termination of supply... distinguished from a lump-sum) professional services contract. (b) Total cost basis. (1) When use of the..., under the contractor's accounting system, unit costs for work in process and finished products cannot...

48 CFR 49.105-4 - Cleanup of construction site.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Cleanup of construction site. 49.105-4 Section 49.105-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-4 Cleanup of construction site. In...

48 CFR 49.108-7 - Government assistance in settling subcontracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government assistance in settling subcontracts. 49.108-7 Section 49.108-7 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-7 Government assistance in...

48 CFR 749.111-71 - Required review and approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Required review and approval. 749.111-71 Section 749.111-71 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 749.111-71 Required review and...

48 CFR 49.304-2 - Submission of settlement proposal (fee only).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Submission of settlement proposal (fee only). 49.304-2 Section 49.304-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS Additional Principles for Cost-Reimbursement...

48 CFR 49.108-2 - Prime contractor's rights and obligations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Prime contractor's rights and obligations. 49.108-2 Section 49.108-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-2 Prime contractor's rights...

48 CFR 949.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fraud or other criminal conduct. 949.106 Section 949.106 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 949.106 Fraud or other criminal conduct. Any evidence...

48 CFR 1449.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fraud or other criminal conduct. 1449.106 Section 1449.106 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1449.106 Fraud or other criminal conduct...

48 CFR 649.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Fraud or other criminal conduct. 649.106 Section 649.106 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles. 649.106 Fraud or other criminal conduct. If the...

48 CFR 1349.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Fraud or other criminal conduct. 1349.106 Section 1349.106 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 1349.106 Fraud or other criminal conduct. If the...

48 CFR 49.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fraud or other criminal conduct. 49.106 Section 49.106 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.106 Fraud or other criminal conduct. If...

24 CFR 203.268 - Pro rata payment of periodic MIP.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic Payment § 203.268 Pro rata payment of periodic MIP. (a) If the insurance contract is terminated...

24 CFR 203.268 - Pro rata payment of periodic MIP.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums-Periodic Payment § 203.268 Pro rata payment of periodic MIP. (a) If the insurance contract is terminated...

48 CFR 970.5232-4 - Obligation of funds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... substantially underrun. (e) Government's right to terminate not affected. The giving of any notice under this... obligated by the Government with respect to this contract is __ dollars ($__). Such amount may be increased... the Government. Except as otherwise provided in this contract and except for costs which may be...

48 CFR 970.5232-4 - Obligation of funds.

Code of Federal Regulations, 2011 CFR

2011-10-01

... substantially underrun. (e) Government's right to terminate not affected. The giving of any notice under this... obligated by the Government with respect to this contract is __ dollars ($__). Such amount may be increased... the Government. Except as otherwise provided in this contract and except for costs which may be...

48 CFR 49.502 - Termination for convenience of the Government.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the Government (Services) (Short Form) is appropriate, (ii) in contracts for research and development... Government (Services) (Short Form), is appropriate (see 49.502(c)), or one of the clauses prescribed or cited... Convenience of the Government (Services) (Short Form), in solicitations and contracts for services, regardless...

48 CFR 3052.209-71 - Reserve Officer Training Corps and military recruiting on campus.

Code of Federal Regulations, 2014 CFR

2014-10-01

... System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) CLAUSES AND FORMS... with the Department of Homeland Security; and (2) The Government will terminate this contract for... ineligible for contract award if the Secretary of Defense determines that the institution has a policy or...

48 CFR 3052.209-71 - Reserve Officer Training Corps and military recruiting on campus.

Code of Federal Regulations, 2010 CFR

2010-10-01

... System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) CLAUSES AND FORMS... with the Department of Homeland Security; and (2) The Government will terminate this contract for... ineligible for contract award if the Secretary of Defense determines that the institution has a policy or...

42 CFR 422.510 - Termination of contract by CMS.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) CMS notifies the MA organization in writing at least 45 calendar days before the intended date of the...; or (B) The MA organization experiences financial difficulties so severe that its ability to make...)(i) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

48 CFR 22.1504 - Violations and remedies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... to cooperate as required in accordance with the clause at 52.222-19, Child Labor Cooperation with Authorities and Remedies, with an investigation of the use of forced or indentured child labor by an Inspector... contractor knew of the violation. (b) Remedies. (1) The contracting officer may terminate the contract. (2...

48 CFR 49.105-2 - Release of excess funds.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Release of excess funds. 49.105-2 Section 49.105-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.105-2 Release of excess funds. (a) The...

48 CFR 49.109-6 - Joint settlement of two or more settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Joint settlement of two or more settlement proposals. 49.109-6 Section 49.109-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-6 Joint...

48 CFR 49.108-6 - Delay in settling subcontractor settlement proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Delay in settling subcontractor settlement proposals. 49.108-6 Section 49.108-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-6 Delay in...

48 CFR 49.108-8 - Assignment of rights under subcontracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Assignment of rights under subcontracts. 49.108-8 Section 49.108-8 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-8 Assignment of rights under...

48 CFR 49.109-4 - No-cost settlement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false No-cost settlement. 49.109-4 Section 49.109-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.109-4 No-cost settlement. The TCO shall execute a...

48 CFR 449.106 - Fraud or other criminal conduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Fraud or other criminal conduct. 449.106 Section 449.106 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 449.106 Fraud or other criminal conduct. (a) If the...

48 CFR 49.108-5 - Recognition of judgments and arbitration awards.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Recognition of judgments and arbitration awards. 49.108-5 Section 49.108-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-5 Recognition of...

12 CFR 956.6 - Use of hedging instruments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... counterparty for over-the-counter derivative contracts shall include: (i) A requirement that market value... reasonable estimate of the market value of the over-the-counter derivative contract at termination (standard.... Derivative instruments that do not qualify as hedging instruments pursuant to GAAP may be used only if a non...

Experimental and Modeling Studies of Massif Anorthosites

NASA Technical Reports Server (NTRS)

Longhi, John

1999-01-01

This termination report covers the latter part of a single research effort spanning several grant cycles. During this time there was a single title, "Experimental and Modeling Studies of Massif Anorthosites", but there were several contract numbers as the mode and location of NASA contract administration changed. Initially, the project was funded as an increment to the PI's other grant, "Early Differentiation of the Moon: Experimental and Modeling Studies", but subsequently it became an independent grant. Table 1 contains a brief summary of the dates and contract numbers.

24 CFR 266.622 - Notice and date of termination by the Commissioner.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Termination § 266.622 Notice and date of termination...

M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: Findings obtained with muscarinic-receptor knockout mouse.

PubMed

Takeuchi, Tadayoshi; Tanaka, Keisuke; Nakajima, Hidemitsu; Matsui, Minoru; Azuma, Yasu-Taka

2007-01-01

The involvement of muscarinic receptors in neurogenic responses of the ileum was studied in wild-type and muscarinic-receptor (M-receptor) knockout (KO) mice. Electrical field stimulation to the wild-type mouse ileum induced a biphasic response, a phasic and sustained contraction that was abolished by tetrodotoxin. The sustained contraction was prolonged for an extended period after the termination of electrical field stimulation. The phasic contraction was completely inhibited by atropine. In contrast, the sustained contraction was enhanced by atropine. Ileal strips prepared from M2-receptor KO mice exhibited a phasic contraction similar to that seen in wild-type mice and a sustained contraction that was larger than that in wild-type mice. In M3-receptor KO mice, the phasic contraction was smaller than that observed in wild-type mice. Acetylcholine exogenously administrated induced concentration-dependent contractions in strips isolated from wild-type, M2- and M3-receptor KO mice. However, contractions in M3-receptor KO mice shifted to the right. The sustained contraction was inhibited by capsaicin and neurokinin NK2 receptor antagonist, suggesting that it is mediated by substance P (SP). SP-induced contraction of M2-receptor KO mice did not differ from that of wild-type mice. SP immunoreactivity was located in enteric neurons, colocalized with M2 receptor immunoreactivity. These results suggest that atropine-sensitive phasic contraction is mainly mediated via the M3 receptor, and SP-mediated sustained contraction is negatively regulated by the M2 receptor at a presynaptic level.

48 CFR 8.406-5 - Termination for the Government's convenience.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Government's convenience. 8.406-5 Section 8.406-5 Federal Acquisition Regulations System FEDERAL ACQUISITION... Termination for the Government's convenience. (a) An ordering activity contracting officer may terminate individual orders for the Government's convenience. Terminations for the Government's convenience shall...

NASA Glenn Research Center Support of the Advanced Stirling Radioisotope Generator Project

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Wong, Wayne A.

2015-01-01

A high-efficiency radioisotope power system was being developed for long-duration NASA space science missions. The U.S. Department of Energy (DOE) managed a flight contract with Lockheed Martin Space Systems Company to build Advanced Stirling Radioisotope Generators (ASRGs), with support from NASA Glenn Research Center. DOE initiated termination of that contract in late 2013, primarily due to budget constraints. Sunpower, Inc., held two parallel contracts to produce Advanced Stirling Convertors (ASCs), one with Lockheed Martin to produce ASC-F flight units, and one with Glenn for the production of ASC-E3 engineering unit "pathfinders" that are built to the flight design. In support of those contracts, Glenn provided testing, materials expertise, Government-furnished equipment, inspection capabilities, and related data products to Lockheed Martin and Sunpower. The technical support included material evaluations, component tests, convertor characterization, and technology transfer. Material evaluations and component tests were performed on various ASC components in order to assess potential life-limiting mechanisms and provide data for reliability models. Convertor level tests were conducted to characterize performance under operating conditions that are representative of various mission conditions. Despite termination of the ASRG flight development contract, NASA continues to recognize the importance of high-efficiency ASC power conversion for Radioisotope Power Systems (RPS) and continues investment in the technology, including the continuation of the ASC-E3 contract. This paper describes key Government support for the ASRG project and future tests to be used to provide data for ongoing reliability assessments.

Dropouts in Swiss Vocational Education and the Effect of Training Companies' Trainee Selection Methods

ERIC Educational Resources Information Center

Forsblom, Lara; Negrini, Lucio; Gurtner, Jean-Luc; Schumann, Stephan

2016-01-01

In the Swiss vocational education system, which is often called a "Dual System", trainees enter into an apprenticeship contract with a training company. On average, 25% of those contracts are terminated prematurely (PCT). This article examines the relationship between training companies' selection methods and PCTs. The investigation is…

41 CFR 102-118.520 - Who is responsible for determining the standards for collection, compromise, termination, or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... outstanding debts to my agency? 102-118.520 Section 102-118.520 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who is responsible for...

The "Make or Buy" Decision: Five Main Points to Consider

ERIC Educational Resources Information Center

Archer, Mary Ann E.

1978-01-01

Five points which should be considered when making decisions about whether to purchase magnetic tapes for in-hours searching by batch processing, purchase terminals and contract with on-line vendors, or contract with information brokers for retrospective searching or SDI are availability of information in the most useful form, hardware and…

Synaptic Activity and Muscle Contraction Increases PDK1 and PKCβI Phosphorylation in the Presynaptic Membrane of the Neuromuscular Junction.

PubMed

Hurtado, Erica; Cilleros, Víctor; Just, Laia; Simó, Anna; Nadal, Laura; Tomàs, Marta; Garcia, Neus; Lanuza, Maria A; Tomàs, Josep

2017-01-01

Conventional protein kinase C βI (cPKCβI) is a conventional protein kinase C (PKC) isoform directly involved in the regulation of neurotransmitter release in the neuromuscular junction (NMJ). It is located exclusively at the nerve terminal and both synaptic activity and muscle contraction modulate its protein levels and phosphorylation. cPKCβI molecular maturation includes a series of phosphorylation steps, the first of which is mediated by phosphoinositide-dependent kinase 1 (PDK1). Here, we sought to localize PDK1 in the NMJ and investigate the hypothesis that synaptic activity and muscle contraction regulate in parallel PDK1 and cPKCβI phosphorylation in the membrane fraction. To differentiate the presynaptic and postsynaptic activities, we abolished muscle contraction with μ-conotoxin GIIIB (μ-CgTx-GIIIB) in some experiments before stimulation of the phrenic nerve (1 Hz, 30 min). Then, we analyzed total and membrane/cytosol fractions of skeletal muscle by Western blotting. Results showed that PDK1 is located exclusively in the nerve terminal of the NMJ. After nerve stimulation with and without coincident muscle contraction, total PDK1 and phosphorylated PDK1 (pPDK1) protein levels remained unaltered. However, synaptic activity specifically enhanced phosphorylation of PDK1 in the membrane, an important subcellular location for PDK1 function. This increase in pPDK1 coincides with a significant increase in the phosphorylation of its substrate cPKCβI also in the membrane fraction. Moreover, muscle contraction maintains PDK1 and pPDK1 but increases cPKCβI protein levels and its phosphorylation. Thus, even though PDK1 activity is maintained, pcPKCβI levels increase in concordance with total cPKCβI. Together, these results indicate that neuromuscular activity could induce the membrane targeting of pPDK1 in the nerve terminal of the NMJ to promote the phosphorylation of the cPKCβI, which is involved in ACh release.

Synaptic Activity and Muscle Contraction Increases PDK1 and PKCβI Phosphorylation in the Presynaptic Membrane of the Neuromuscular Junction

PubMed Central

Hurtado, Erica; Cilleros, Víctor; Just, Laia; Simó, Anna; Nadal, Laura; Tomàs, Marta; Garcia, Neus; Lanuza, Maria A.; Tomàs, Josep

2017-01-01

Conventional protein kinase C βI (cPKCβI) is a conventional protein kinase C (PKC) isoform directly involved in the regulation of neurotransmitter release in the neuromuscular junction (NMJ). It is located exclusively at the nerve terminal and both synaptic activity and muscle contraction modulate its protein levels and phosphorylation. cPKCβI molecular maturation includes a series of phosphorylation steps, the first of which is mediated by phosphoinositide-dependent kinase 1 (PDK1). Here, we sought to localize PDK1 in the NMJ and investigate the hypothesis that synaptic activity and muscle contraction regulate in parallel PDK1 and cPKCβI phosphorylation in the membrane fraction. To differentiate the presynaptic and postsynaptic activities, we abolished muscle contraction with μ-conotoxin GIIIB (μ-CgTx-GIIIB) in some experiments before stimulation of the phrenic nerve (1 Hz, 30 min). Then, we analyzed total and membrane/cytosol fractions of skeletal muscle by Western blotting. Results showed that PDK1 is located exclusively in the nerve terminal of the NMJ. After nerve stimulation with and without coincident muscle contraction, total PDK1 and phosphorylated PDK1 (pPDK1) protein levels remained unaltered. However, synaptic activity specifically enhanced phosphorylation of PDK1 in the membrane, an important subcellular location for PDK1 function. This increase in pPDK1 coincides with a significant increase in the phosphorylation of its substrate cPKCβI also in the membrane fraction. Moreover, muscle contraction maintains PDK1 and pPDK1 but increases cPKCβI protein levels and its phosphorylation. Thus, even though PDK1 activity is maintained, pcPKCβI levels increase in concordance with total cPKCβI. Together, these results indicate that neuromuscular activity could induce the membrane targeting of pPDK1 in the nerve terminal of the NMJ to promote the phosphorylation of the cPKCβI, which is involved in ACh release. PMID:28890686

Peruvian projects, privatization proceeding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-10-19

This paper reports that Petroleos del Peru is forging ahead on several fronts despite Peru's political turmoil and uncertainty over where government ordered-privatization will take it. The state oil company: is expected to sign contract soon related to development of Chambira oil field in the northern jungle; let contract to a group of Peruvian and Brazilian companies for construction of an oil terminal at Talara on the Pacific coast; and received expressions of interest in participating in an operating contract on an offshore block operated by its Petromar SA offshore subsidiary under the government's privatization program.

Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3.

PubMed

Strittmatter, F; Walther, S; Gratzke, C; Göttinger, J; Beckmann, C; Roosen, A; Schlenker, B; Hedlund, P; Andersson, K E; Stief, C G; Hennenberg, M

2012-07-01

BACKGROUND AND PURPOSE α(1) -Adrenoceptor-induced contraction of prostate smooth muscle is mediated by calcium- and Rho kinase-dependent mechanisms. In addition, other mechanisms, such as activation of c-jun N-terminal kinase (JNK) may be involved. Here, we investigated whether JNK participates in α(1)-adrenoceptor-induced contraction of human prostate smooth muscle. EXPERIMENTAL APPROACH Prostate tissue was obtained from patients undergoing radical prostatectomy. Effects of the JNK inhibitors SP600125 (50 µM) and BI-78D3 (30 µM) on contractions induced by phenylephrine, noradrenaline and electric field stimulation (EFS) were studied in myographic measurements. JNK activation by noradrenaline (30 µM) and phenylephrine (10 µM), and the effects of JNK inhibitors of c-Jun phosphorylation were assessed by Western blot analyses with phospho-specific antibodies. Expression of JNK was studied by immunohistochemistry and fluorescence double staining. KEY RESULTS The JNK inhibitors SP600125 and BI-78D3 reduced phenylephrine- and noradrenaline-induced contractions of human prostate strips. In addition, SP600125 reduced EFS-induced contraction of prostate strips. Stimulation of prostate tissue with noradrenaline or phenylephrine in vitro resulted in activation of JNK. Incubation of prostate tissue with SP600125 or BI-78D3 reduced the phosphorylation state of c-Jun. Immunohistochemical staining demonstrated the expression of JNK in smooth muscle cells of human prostate tissue. Fluorescence staining showed that α(1A)-adrenoceptors and JNK are expressed in the same cells. CONCLUSIONS AND IMPLICATIONS Activation of JNK is involved in α(1)-adrenoceptor-induced prostate smooth muscle contraction. Models of α(1)-adrenoceptor-mediated prostate smooth muscle contraction should include this JNK-dependent mechanism. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

24 CFR 203.321 - Effect of termination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Effect of termination. 203.321 Section 203.321 Housing and Urban Development Regulations Relating to Housing and Urban Development....321 Effect of termination. Upon termination of the contract of insurance, the obligation to pay any...

41 CFR 302-3.227 - If I become divorced from my spouse or terminate my committed relationship with my domestic...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false If I become divorced... Section 302-3.227 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Prior Return of...

41 CFR 302-3.227 - If I become divorced from my spouse or terminate my committed relationship with my domestic...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false If I become divorced... Section 302-3.227 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Prior Return of...

41 CFR 302-3.227 - If I become divorced from my spouse or terminate my committed relationship with my domestic...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true If I become divorced from....227 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Prior Return of Immediate...

41 CFR 302-3.227 - If I become divorced from my spouse or terminate my committed relationship with my domestic...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false If I become divorced... Section 302-3.227 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Prior Return of...

The Role of Collegiality in Higher Education Tenure, Promotion, and Termination Decisions.

ERIC Educational Resources Information Center

Connell, Mary Ann; Savage, Frederick G.

2001-01-01

Presents an analysis of the arguments for and against consideration of collegiality in higher education employment decisions and a review of the relevant case law. Critics argue that unless collegiality is specified as a separate criterion for evaluation in the faculty contract or handbook, its use is a breach of contract. Others are concerned…

9 CFR 201.217 - Reasonable period of time to remedy a breach of contract.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Reasonable period of time to remedy a breach of contract. 201.217 Section 201.217 Animals and Animal Products GRAIN INSPECTION, PACKERS AND... termination. These criteria do not limit a packer, swine contractor or live poultry dealer's rights under a...

9 CFR 201.217 - Reasonable period of time to remedy a breach of contract.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Reasonable period of time to remedy a breach of contract. 201.217 Section 201.217 Animals and Animal Products GRAIN INSPECTION, PACKERS AND... termination. These criteria do not limit a packer, swine contractor or live poultry dealer's rights under a...

9 CFR 201.217 - Reasonable period of time to remedy a breach of contract.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Reasonable period of time to remedy a breach of contract. 201.217 Section 201.217 Animals and Animal Products GRAIN INSPECTION, PACKERS AND... termination. These criteria do not limit a packer, swine contractor or live poultry dealer's rights under a...

Surface-EMG analysis for the quantification of thigh muscle dynamic co-contractions during normal gait.

PubMed

Strazza, Annachiara; Mengarelli, Alessandro; Fioretti, Sandro; Burattini, Laura; Agostini, Valentina; Knaflitz, Marco; Di Nardo, Francesco

2017-01-01

The research purpose was to quantify the co-contraction patterns of quadriceps femoris (QF) vs. hamstring muscles during free walking, in terms of onset-offset muscular activation, excitation intensity, and occurrence frequency. Statistical gait analysis was performed on surface-EMG signals from vastus lateralis (VL), rectus femoris (RF), and medial hamstrings (MH), in 16315 strides walked by 30 healthy young adults. Results showed full superimpositions of MH with both VL and RF activity from terminal swing, 80 to 100% of gait cycle (GC), to the successive loading response (≈0-15% of GC), in around 90% of the considered strides. A further superimposition was detected during the push-off phase both between VL and MH activation intervals (38.6±12.8% to 44.1±9.6% of GC) in 21.9±13.6% of strides, and between RF and MH activation intervals (45.9±5.3% to 50.7±9.7 of GC) in 32.7±15.1% of strides. These findings led to identify three different co-contractions among QF and hamstring muscles during able-bodied walking: in early stance (in ≈90% of strides), in push-off (in 25-30% of strides) and in terminal swing (in ≈90% of strides). The co-contraction in terminal swing is the one with the highest levels of muscle excitation intensity. To our knowledge, this analysis represents the first attempt for quantification of QF/hamstring muscles co-contraction in young healthy subjects during normal gait, able to include the physiological variability of the phenomenon. Copyright © 2016 Elsevier B.V. All rights reserved.

Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.

PubMed

Parsons, Sean P; Huizinga, Jan D

2015-02-15

Waves of contraction in the small intestine correlate with slow waves generated by the myenteric network of interstitial cells of Cajal. Coupled oscillator theory has been used to explain steplike gradients in the frequency (frequency plateaux) of contraction waves along the length of the small intestine. Inhibition of gap junction coupling between oscillators should lead to predictable effects on these plateaux and the wave dislocation (wave drop) phenomena associated with their boundaries. It is these predictions that we wished to test. We used a novel multicamera diameter-mapping system to measure contraction along 25- to 30-cm lengths of murine small intestine. There were typically two to three plateaux per length of intestine. Dislocations could be limited to the wavefronts immediately about the terminated wave, giving the appearance of a three-pronged fork, i.e., a fork dislocation; additionally, localized decreases in velocity developed across a number of wavefronts, ending with the terminated wave, which could appear as a fork, i.e., slip dislocations. The gap junction inhibitor carbenoxolone increased the number of plateaux and dislocations and decreased contraction wave velocity. In some cases, the usual frequency gradient was reversed, with a plateau at a higher frequency than its proximal neighbor; thus fork dislocations were inverted, and the direction of propagation was reversed. Heptanol had no effect on the frequency or velocity of contractions but did reduce their amplitude. To understand intestinal motor patterns, the pacemaker network of the interstitial cells of Cajal is best evaluated as a system of coupled oscillators. Copyright © 2015 the American Physiological Society.

48 CFR 3023.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 3023.506 Suspension of payments, termination of...

48 CFR 3023.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 3023.506 Suspension of payments, termination of...

48 CFR 3023.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 3023.506 Suspension of payments, termination of...

48 CFR 12.403 - Termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... guidance to the extent that part 49 does not conflict with this section and the language of the termination... required to comply with the cost accounting standards or the contract cost principles in part 31. The...

Evidence against nitrergic neuromodulation in the rat vas deferens.

PubMed

Ventura, S; Burnstock, G

1997-09-03

Electrical field stimulation (60 V, 1 ms, single pulses or 20 s trains of 1-10 Hz) of the nerve terminals within the rat vas deferens produced biphasic contractions in preparations oriented to measure either longitudinal or circular muscle contractions. In confirmation of earlier reports, these contractions were blocked by tetrodotoxin (1 microM). The initial fast purinergic contraction was dominant in prostatic halves of the vas deferens while the second slower noradrenergic contraction was greater in epididymal halves. Although previous studies have shown nitric oxide synthase immuno-positive nerves in the vas deferens, electrical field stimulation-induced contractions were unaffected by L-arginine, sodium nitroprusside, N-nitro-L-arginine methyl ester (L-NAME) or superoxide dismutase in concentrations up to I mM. In concentrations above 1 mM, L-NAME reduced the size of the field stimulation-induced contractions but this effect could not be reversed by either L-arginine or sodium nitroprusside. Furthermore, L-arginine, sodium nitroprusside and L-NAME did not affect the contractions induced by exogenous application of noradrenaline (10 microM), ATP (1 mM) or BaCl2 (1-10 mM). We conclude that nitric oxide does not act as a neuromodulator in isolated preparations of rat vas deferens.

7 CFR 623.6 - Transfer of lands from the CRP to the EWRP.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Transfer of lands from the CRP to the EWRP. 623.6... Transfer of lands from the CRP to the EWRP. Land that is subject to an existing CRP contract administered... requested by the owner and approved by CCC, the CRP contract for the property will be terminated or...

Contraction of the Ventral Abdomen Potentiates Extracardiac Retrograde Hemolymph Propulsion in the Mosquito Hemocoel

PubMed Central

Andereck, Jonathan W.; King, Jonas G.; Hillyer, Julián F.

2010-01-01

Background Hemolymph circulation in mosquitoes is primarily controlled by the contractile action of a dorsal vessel that runs underneath the dorsal midline and is subdivided into a thoracic aorta and an abdominal heart. Wave-like peristaltic contractions of the heart alternate in propelling hemolymph in anterograde and retrograde directions, where it empties into the hemocoel at the terminal ends of the insect. During our analyses of hemolymph propulsion in Anopheles gambiae, we observed periodic ventral abdominal contractions and hypothesized that they promote extracardiac hemolymph circulation in the abdominal hemocoel. Methodology/Principal Findings We devised methods to simultaneously analyze both heart and abdominal contractions, as well as to measure hemolymph flow in the abdominal hemocoel. Qualitative and quantitative analyses revealed that ventral abdominal contractions occur as series of bursts that propagate in the retrograde direction. Periods of ventral abdominal contraction begin only during periods of anterograde heart contraction and end immediately following a heartbeat directional reversal, suggesting that ventral abdominal contractions function to propel extracardiac hemolymph in the retrograde direction. To test this functional role, fluorescent microspheres were intrathoracically injected and their trajectory tracked throughout the hemocoel. Quantitative measurements of microsphere movement in extracardiac regions of the abdominal cavity showed that during periods of abdominal contractions hemolymph flows in dorsal and retrograde directions at a higher velocity and with greater acceleration than during periods of abdominal rest. Histochemical staining of the abdominal musculature then revealed that ventral abdominal contractions result from the contraction of intrasegmental lateral muscle fibers, intersegmental ventral muscle bands, and the ventral transverse muscles that form the ventral diaphragm. Conclusions/Significance These data show that abdominal contractions potentiate extracardiac retrograde hemolymph propulsion in the abdominal hemocoel during periods of anterograde heart flow. PMID:20886066

48 CFR 1649.101-72 - FEHBP termination for default clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false FEHBP termination for default clause. 1649.101-72 Section 1649.101-72 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-71 - FEHBP termination for convenience clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false FEHBP termination for convenience clause. 1649.101-71 Section 1649.101-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-72 - FEHBP termination for default clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false FEHBP termination for default clause. 1649.101-72 Section 1649.101-72 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-71 - FEHBP termination for convenience clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false FEHBP termination for convenience clause. 1649.101-71 Section 1649.101-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-71 - FEHBP termination for convenience clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false FEHBP termination for convenience clause. 1649.101-71 Section 1649.101-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-71 - FEHBP termination for convenience clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false FEHBP termination for convenience clause. 1649.101-71 Section 1649.101-71 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-72 - FEHBP termination for default clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false FEHBP termination for default clause. 1649.101-72 Section 1649.101-72 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 1649.101-72 - FEHBP termination for default clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false FEHBP termination for default clause. 1649.101-72 Section 1649.101-72 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CONTRACT MANAGEMENT TERMINATION OF...

48 CFR 970.4905-1 - Termination for convenience of the government and default.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Termination for convenience of the government and default. 970.4905-1 Section 970.4905-1 Federal Acquisition Regulations... Termination of Contracts 970.4905-1 Termination for convenience of the government and default. (a) The...

The managed care contract: the blueprint for monitoring agreements.

PubMed

Hummel, J R; Cooper, S J

2001-06-01

Healthcare providers generally undertake monitoring programs of managed care arrangements as a way of analyzing financial performance, uncovering lapses in contractually mandated performance that might expose the organization to financial loss, and gathering information that can be helpful in renegotiating the contract or negotiating new arrangements. To secure access to the information needed to achieve these goals, the provider should ensure that the contract spells out the information required, the health plan's obligations to supply this information, and the consequences of the plan's failure to meet those obligations. Such consequences may include financial penalties for the plan and special termination rights for the provider. Without a contractually explicit assurance that the needed information will be available, a provider may find itself with no way to achieve its contract-monitoring goals.

Operation Arctic Heat Case and Exercise for Advanced Contingency Contracting

DTIC Science & Technology

2012-04-30

hOme early fOr repa1rs ~r belno ttilll’lmcd by lii tugi:IOM, !hereby ~no a kw ~raptts In dli! t>aNy ttfaiF. A ~~an C- 130 Svj)et ~Iii::$ m lllt! iry ...and procedures for return of all rental items; (ii) Det ermine which contract s require forma l termination for convenience actions and init iate

Structural Basis for the Regulation of Muscle Contraction by Troponin and Tropomyosin

PubMed Central

Galińska-Rakoczy, Agnieszka; Engel, Patti; Xu, Chen; Jung, HyunSuk; Craig, Roger; Tobacman, Larry S.; Lehman, William

2008-01-01

The molecular switching mechanism governing skeletal and cardiac muscle contraction couples the binding of Ca2+ on troponin to the movement of tropomyosin on actin filaments. Despite years of investigation, this mechanism remains unclear because it has not yet been possible to directly assess the structural influence of troponin on tropomyosin that causes actin filaments, and hence myosin-crossbridge cycling and contraction, to switch on and off. A C-terminal domain of troponin I is thought to be intimately involved in inducing tropomyosin movement to an inhibitory position that blocks myosin-crossbridge interaction. Release of this regulatory, latching domain from actin after Ca2+-binding to TnC presumably allows tropomyosin movement away from the inhibitory position on actin, thus initiating contraction. However, the structural interactions of the regulatory domain of TnI with tropomyosin and actin that cause tropomyosin movement are unknown and thus the regulatory process is not well defined. Here, thin filaments were labeled with an engineered construct representing C-terminal TnI and then 3D-EM was used to resolve where troponin is anchored on actin-tropomyosin. EM-reconstruction showed how TnI-binding to both actin and tropomyosin at low-Ca2+ competes with tropomyosin for a common site on actin and drives tropomyosin movement to a constrained, relaxing position to inhibit myosin-crossbridge association. Thus the observations reported reveal the structural mechanism responsible for troponin-tropomyosin-mediated steric-interference of actin-myosin interaction that regulates muscle contraction. PMID:18514658

The Morning After: What Happens When Outsourcing Relationships End?

NASA Astrophysics Data System (ADS)

Barney, Hamish T.; Low, Graham C.; Aurum, Aybüke

Many firms are reevaluating their initial outsourcing decisions for various reasons, including whether the goals set for the outsourcing effort were achieved, changes in the business environment, internal changes, and/or mergers. An increasing number of outsourcing deals are being terminated and backsourced or re-outsourced. According to a recent international industry survey 49% of companies engaged in outsourcing have terminated outsourcing contracts prematurely. Research has not reflected this trend with few studies concentrating on what firms do after they terminate or fail to extend an outsourcing contract. It is argued that there is a need to study this important and increasingly frequent decision. The main contribution of this chapter is to present an outsourcing decision model and demonstrate its applicability with respect to a recent sourcing decision.

Energy Transformation in Molecular Electronic Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasha, Michael

1999-05-17

This laboratory has developed many new ideas and methods in the electronic spectroscopy of molecules. This report covers the contract period 1993-1995. A number of the projects were completed in 1996, and those papers are included in the report. The DOE contract was terminated at the end of 1995 owing to a reorganizational change eliminating nationally the projects under the Office of Health and Environmental Research, U. S. Department of Energy.

48 CFR 1.603-4 - Termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Termination. 1.603-4 Section 1.603-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Career Development, Contracting Authority, and Responsibilities 1.603-4...

48 CFR 49.105 - Duties of termination contracting officer after issuance of notice of termination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... for transfer of title and delivery to the Government of any material required by the Government; (8...) Obligation of the contractor to furnish accurate, complete, and current cost or pricing data, and to certify...

Tetrodotoxin-insensitive electrical field stimulation-induced contractions on Crotalus durissus terrificus corpus cavernosum.

PubMed

Campos, Rafael; Mónica, Fabíola Z; Rodrigues, Renata Lopes; Rojas-Moscoso, Julio Alejandro; Moreno, Ronilson Agnaldo; Cogo, José Carlos; de Oliveira, Marco Antonio; Antunes, Edson; De Nucci, Gilberto

2017-01-01

Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced contraction on corpora cavernosa isolated from Crotalus durissus terrificus were not investigated. Crotalus and rabbit corpora cavernosa were mounted in 10 mL organ baths for isometric tension recording. Electrical field stimulation (EFS)-induced contractions were performed in presence/absence of phentolamine (10 μM), guanethidine (30 μM), tetrodotoxin (1 μM and 1mM), A-803467 (10 μM), 3-iodo-L-Tyrosine (1 mM), salsolinol (3 μM) and a modified Krebs solution (equimolar substitution of NaCl by N-methyl-D-glucamine). Immuno-histochemistry for tyrosine hydroxylase was also performed. Electrical field stimulation (EFS; 8 Hz and 16 Hz) caused contractions in both Crotalus and rabbit corpora cavernosa. The contractions were abolished by previous incubation with either phentolamine or guanethidine. Tetrodotoxin (1 μM) also abolished the EFS-induced contractions of rabbit CC, but did not affect EFS-induced contractions of Crotalus CC. Addition of A-803467 (10 μM) did not change the EFS-induced contractions of Crotalus CC but abolished rabbit CC contractions. 3-iodo-L-Tyrosine and salsolinol had no effect on EFS-induced contractions of Crotalus CC and Rabbit CC. Replacement of NaCl by N- Methyl-D-glucamine (NMDG) abolished EFS-induced contractions of rabbit CC, but did not affect Crotalus CC. The presence of tyrosine hydroxylase was identified in endothelial cells only of Crotalus CC. Since the EFS-induced contractions of Crotalus CC is dependent on catecholamine release, insensitive to TTX, insensitive to A803467 and to NaCl replacement, it indicates that the source of cathecolamine is unlikely to be from adrenergic terminals. The finding that tyrosine hydroxylase is present in endothelial cells suggests that these cells can modulate Crotalus CC tone.

48 CFR 52.249-4 - Termination for Convenience of the Government (Services) (Short Form).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Convenience of the Government (Services) (Short Form). 52.249-4 Section 52.249-4 Federal Acquisition... CONTRACT CLAUSES Text of Provisions and Clauses 52.249-4 Termination for Convenience of the Government... convenience of the Government, limit termination settlement charges to services rendered before the date of...

24 CFR 203.462 - Pro rata payment of premium before termination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Pro rata payment of premium before termination. No contract of insurance shall be terminated until the lender has paid to the Commissioner the pro rata portion of the current annual insurance premium. ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Pro rata payment of premium before...

24 CFR 203.462 - Pro rata payment of premium before termination.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Pro rata payment of premium before termination. No contract of insurance shall be terminated until the lender has paid to the Commissioner the pro rata portion of the current annual insurance premium. ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Pro rata payment of premium before...

The role of TRPP2 in agonist-induced gallbladder smooth muscle contraction.

PubMed

Zhong, Xingguo; Fu, Jie; Song, Kai; Xue, Nairui; Gong, Renhua; Sun, Dengqun; Luo, Huilai; He, Wenzhu; Pan, Xiang; Shen, Bing; Du, Juan

2016-04-01

TRPP2 channel protein belongs to the superfamily of transient receptor potential (TRP) channels and is widely expressed in various tissues, including smooth muscle in digestive gut. Accumulating evidence has demonstrated that TRPP2 can mediate Ca(2+) release from Ca(2+) stores. However, the functional role of TRPP2 in gallbladder smooth muscle contraction still remains unclear. In this study, we used Ca(2+) imaging and tension measurements to test agonist-induced intracellular Ca(2+) concentration increase and smooth muscle contraction of guinea pig gallbladder, respectively. When TRPP2 protein was knocked down in gallbladder muscle strips from guinea pig, carbachol (CCh)-evoked Ca(2+) release and extracellular Ca(2+) influx were reduced significantly, and gallbladder contractions induced by endothelin 1 and cholecystokinin were suppressed markedly as well. CCh-induced gallbladder contraction was markedly suppressed by pretreatment with U73122, which inhibits phospholipase C to terminate inositol 1,4,5-trisphosphate receptor (IP3) production, and 2-aminoethoxydiphenyl borate (2APB), which inhibits IP3 recepor (IP3R) to abolish IP3R-mediated Ca(2+) release. To confirm the role of Ca(2+) release in CCh-induced gallbladder contraction, we used thapsigargin (TG)-to deplete Ca(2+) stores via inhibiting sarco/endoplasmic reticulum Ca(2+)-ATPase and eliminate the role of store-operated Ca(2+) entry on the CCh-induced gallbladder contraction. Preincubation with 2 μmol L(-1) TG significantly decreased the CCh-induced gallbladder contraction. In addition, pretreatments with U73122, 2APB or TG abolished the difference of the CCh-induced gallbladder contraction between TRPP2 knockdown and control groups. We conclude that TRPP2 mediates Ca(2+) release from intracellular Ca(2+) stores, and has an essential role in agonist-induced gallbladder muscle contraction.

Structural basis for the regulation of muscle contraction by troponin and tropomyosin.

PubMed

Galińska-Rakoczy, Agnieszka; Engel, Patti; Xu, Chen; Jung, Hyunsuk; Craig, Roger; Tobacman, Larry S; Lehman, William

2008-06-20

The molecular switching mechanism governing skeletal and cardiac muscle contraction couples the binding of Ca2+ on troponin to the movement of tropomyosin on actin filaments. Despite years of investigation, this mechanism remains unclear because it has not yet been possible to directly assess the structural influence of troponin on tropomyosin that causes actin filaments, and hence myosin-crossbridge cycling and contraction, to switch on and off. A C-terminal domain of troponin I is thought to be intimately involved in inducing tropomyosin movement to an inhibitory position that blocks myosin-crossbridge interaction. Release of this regulatory, latching domain from actin after Ca2+ binding to TnC (the Ca2+ sensor of troponin that relieves inhibition) presumably allows tropomyosin movement away from the inhibitory position on actin, thus initiating contraction. However, the structural interactions of the regulatory domain of TnI (the "inhibitory" subunit of troponin) with tropomyosin and actin that cause tropomyosin movement are unknown, and thus, the regulatory process is not well defined. Here, thin filaments were labeled with an engineered construct representing C-terminal TnI, and then, 3D electron microscopy was used to resolve where troponin is anchored on actin-tropomyosin. Electron microscopy reconstruction showed how TnI binding to both actin and tropomyosin at low Ca2+ competes with tropomyosin for a common site on actin and drives tropomyosin movement to a constrained, relaxing position to inhibit myosin-crossbridge association. Thus, the observations reported reveal the structural mechanism responsible for troponin-tropomyosin-mediated steric interference of actin-myosin interaction that regulates muscle contraction.

7 CFR 634.18 - Termination of project.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Termination of project. 634.18 Section 634.18 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.18 - Termination of project.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Termination of project. 634.18 Section 634.18 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.18 - Termination of project.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Termination of project. 634.18 Section 634.18 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.18 - Termination of project.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Termination of project. 634.18 Section 634.18 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.18 - Termination of project.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Termination of project. 634.18 Section 634.18 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

42 CFR 423.508 - Modification or termination of contract by mutual consent.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Prohibition against Part D program participation by organizations whose owners, directors, or management employees served in a similar capacity with another organization that mutually terminated its Medicare... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT...

42 CFR 423.508 - Modification or termination of contract by mutual consent.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Prohibition against Part D program participation by organizations whose owners, directors, or management employees served in a similar capacity with another organization that mutually terminated its Medicare... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION DRUG...

42 CFR 423.508 - Modification or termination of contract by mutual consent.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Prohibition against Part D program participation by organizations whose owners, directors, or management employees served in a similar capacity with another organization that mutually terminated its Medicare... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION DRUG...

42 CFR 423.508 - Modification or termination of contract by mutual consent.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Prohibition against Part D program participation by organizations whose owners, directors, or management employees served in a similar capacity with another organization that mutually terminated its Medicare... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION DRUG...

48 CFR 849.101 - Authorities and responsibilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Authorities and responsibilities. 849.101 Section 849.101 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... language and appeal rights. (b) Contracts containing a mutual termination clause may be terminated without...

48 CFR 849.101 - Authorities and responsibilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Authorities and responsibilities. 849.101 Section 849.101 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... language and appeal rights. (b) Contracts containing a mutual termination clause may be terminated without...

48 CFR 849.101 - Authorities and responsibilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Authorities and responsibilities. 849.101 Section 849.101 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... language and appeal rights. (b) Contracts containing a mutual termination clause may be terminated without...

48 CFR 849.101 - Authorities and responsibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Authorities and responsibilities. 849.101 Section 849.101 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... language and appeal rights. (b) Contracts containing a mutual termination clause may be terminated without...

Insights into managed care--operational, legal and actuarial.

PubMed

Melek, S P; Johnson, B A; Schryver, D

1997-01-01

Understanding the operational, legal and actuarial dimensions of managed care is essential to developing managed care contracts between managed care organizations and individual health care providers or groups such as provider-sponsored organizations or independent practice associations. Operationally, it is important to understand managed care and its trends, emphasizing business issues, knowing your practice and defining acceptable levels of reimbursement and risk. Legally, there are a number of common themes or issues relevant to all managed care contracts, including primary care vs. specialist contracts, services offered, program policies and procedures, utilization review, physician reimbursement and compensation, payment schedule, terms and conditions, term and termination, continuation of care requirements, indemnification, amendment of contract and program policies, and stop-loss insurance. Actuarial issues include membership, geography, age-gender distribution, degree of health care management, local managed care utilization levels, historical utilization levels, health plan benefit design, among others.

[Applications of botulinum toxin in Neurology].

PubMed

Garcia-Ruiz, Pedro J

2013-07-07

At present, botulinum toxin (BT) is one of the most fundamental available drugs in Neurology, only comparable with levodopa. BT is currently used in those entities characterized by excessive muscle contraction, including dystonia and spasticity. In addition, BT has been used to control pain associated with increased muscle contraction in dystonia and spasticity, but also is useful to control chronic pain not associated with muscle contraction, such as chronic daily headache. Finally, BT is useful in sialorrhoea and bruxism. The mechanism of action is complex, mainly acting on terminal neuromuscular junction, but also exhibiting analgesic properties, probably through inhibition of pain neurotransmitters release. Copyright © 2012 Elsevier España, S.L. All rights reserved.

Contracts, grants and funding summary of supersonic cruise research and variable-cycle engine technology programs, 1972 - 1982

NASA Technical Reports Server (NTRS)

Hoffman, S.; Varholic, M. C.

1983-01-01

NASA-SCAR (AST) program was initiated in 1972 at the direct request of the Executive Office of the White House and Congress following termination of the U.S. SST program. The purpose of SCR was to conduct a focused research and technology program on those technology programs which contributed to the SST termination and, also, to provide an expanded data base for future civil and military supersonic transport aircraft. Funding for the Supersonic Cruise Research (SCR) Program was initiated in fiscal year 1973 and terminated in fiscal year 1981. The program was implemented through contracts and grants with industry, universities, and by in-house investigations at the NASA/OAST centers. The studies included system studies and five disciplines: propulsion, stratospheric emissions impact, materials and structures, aerodynamic performance, and stability and control. The NASA/Lewis Variable-Cycle Engine (VCE) Component Program was initiated in 1976 to augment the SCR program in the area of propulsion. After about 2 years, the title was changed to VCE Technology program. The total number of contractors and grantees on record at the AST office in 1982 was 101 for SCR and 4 for VCE. This paper presents a compilation of all the contracts and grants as well as the funding summaries for both programs.

Moral and Legal Issues Surrounding Terminal Sedation and Physician Assisted Suicide

DTIC Science & Technology

2002-09-23

1 MORAL AND LEGAL ISSUES SURROUNDING TERMINAL SEDATION AND PHYSICIAN ASSISTED SUICIDE by CONSTANCE ReJENNA BRADLEY B.S., United States Air Force...Title and Subtitle Moral and Legal Issues Surrounding Terminal Sedation and Physician-Assisted Suicide Contract Number Grant Number Program...Constance ReJenna (M.A., Philosophy) Moral and Legal Issues Surrounding Terminal Sedation and Physician Assisted Suicide Thesis directed by Instructor

c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis

DTIC Science & Technology

2014-10-01

AWARD NUMBER: W81XWH-12-1-0431 TITLE: “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis ” PRINCIPAL INVESTIGATOR...TITLE AND SUBTITLE “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Scelerosis” 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH

Sex differences in neuromuscular function after repeated eccentric contractions of the knee extensor muscles.

PubMed

Lee, Andrea; Baxter, Jake; Eischer, Claire; Gage, Matt; Hunter, Sandra; Yoon, Tejin

2017-06-01

This study examined the mechanisms for force and power reduction during and up to 48 h after maximal eccentric contractions of the knee extensor muscles in young men and women. 13 men (22.8 ± 2.6 years) and 13 women (21.6 ± 2.2 years) performed 150 maximal effort eccentric contractions (5 sets of 30) with the knee extensor muscles at 60° s -1 . Maximal voluntary isometric contractions (MVIC) and maximal voluntary concentric contractions (MVCC) were performed before and after the 150 eccentric contractions. The MVCCs involved a set of two isokinetic contractions at 60° s -1 and sets of isotonic contractions performed at seven different resistance loads (1 N m, 10, 20, 30, 40, 50, and 60% MVIC). Electrical stimulation was used during the MVICs and at rest to determine changes in voluntary activation and contractile properties. At baseline, men were stronger than women (MVIC: 276 ± 48 vs. 133 ± 37 N m) and more powerful (MVCC: 649 ± 77 vs. 346 ± 78 W). At termination of the eccentric contractions, voluntary activation, resting twitch amplitude, and peak power during concentric contractions at the seven loads and at 60° s -1 decreased (P < 0.05) similarly in the men and women. At 48 h post-exercise, the MVIC torque, power (for loads ≥20-60% MVIC), and voluntary activation remained depressed (P < 0.05), but the resting twitch had returned to baseline (P > 0.05) with no sex differences. Central mechanisms were primarily responsible for the depressed maximal force production up to 48 h after repeated eccentric contractions of the knee extensors and these mechanisms were similar in men and women.

Expected performance of m-solution backtracking

NASA Technical Reports Server (NTRS)

Nicol, D. M.

1986-01-01

This paper derives upper bounds on the expected number of search tree nodes visited during an m-solution backtracking search, a search which terminates after some preselected number m problem solutions are found. The search behavior is assumed to have a general probabilistic structure. The results are stated in terms of node expansion and contraction. A visited search tree node is said to be expanding if the mean number of its children visited by the search exceeds 1 and is contracting otherwise. It is shown that if every node expands, or if every node contracts, then the number of search tree nodes visited by a search has an upper bound which is linear in the depth of the tree, in the mean number of children a node has, and in the number of solutions sought. Also derived are bounds linear in the depth of the tree in some situations where an upper portion of the tree contracts (expands), while the lower portion expands (contracts). While previous analyses of 1-solution backtracking have concluded that the expected performance is always linear in the tree depth, the model allows superlinear expected performance.

5 CFR 890.304 - Termination of enrollment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Enrollment § 890.304 Termination of... individual contract for health benefits. (e) Temporary continuation of coverage. Employees and family members... entitling him or her to benefits under part 353 of this chapter, or similar authority, for the purpose of...

5 CFR 890.304 - Termination of enrollment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH BENEFITS PROGRAM Enrollment § 890.304 Termination of... individual contract for health benefits. (e) Temporary continuation of coverage. Employees and family members... entitling him or her to benefits under part 353 of this chapter, or similar authority, for the purpose of...

7 CFR 634.17 - Termination of grant agreement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Termination of grant agreement. 634.17 Section 634.17 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.17 - Termination of grant agreement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Termination of grant agreement. 634.17 Section 634.17 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.17 - Termination of grant agreement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Termination of grant agreement. 634.17 Section 634.17 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 634.17 - Termination of grant agreement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Termination of grant agreement. 634.17 Section 634.17 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Project Authorization and Funding...

7 CFR 636.12 - Termination of cost-share agreements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Termination of cost-share agreements. 636.12 Section 636.12 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.12 - Termination of cost-share agreements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Termination of cost-share agreements. 636.12 Section 636.12 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.12 - Termination of cost-share agreements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Termination of cost-share agreements. 636.12 Section 636.12 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.12 - Termination of cost-share agreements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Termination of cost-share agreements. 636.12 Section 636.12 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVE PROGRAM § 636...

7 CFR 636.12 - Termination of cost-share agreements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Termination of cost-share agreements. 636.12 Section 636.12 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING WILDLIFE HABITAT INCENTIVES PROGRAM § 636...

48 CFR 52.249-1 - Termination for Convenience of the Government (Fixed-Price) (Short Form).

Code of Federal Regulations, 2014 CFR

2014-10-01

..., may terminate this contract, in whole or in part, when it is in the Government's interest. If this..., except for property that the Contractor (a) disposed of by bona fide sale or (b) removed from the site...

46 CFR Sec. 3 - Terminal operating contract.

Code of Federal Regulations, 2011 CFR

2011-10-01

... _________, 19__, between the United States of America (herein called the “United States”), acting by and through...'s work under the provisions of this agreement the following: (1) For terminal services, an amount... first above written. (Seal) Attest: united states of america, department of transportation, maritime...

46 CFR Sec. 3 - Terminal operating contract.

Code of Federal Regulations, 2012 CFR

2012-10-01

... _________, 19__, between the United States of America (herein called the “United States”), acting by and through...'s work under the provisions of this agreement the following: (1) For terminal services, an amount... first above written. (Seal) Attest: united states of america, department of transportation, maritime...

75 FR 52619 - Entitlement and Termination Requirements for Stepchildren

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... SOCIAL SECURITY ADMINISTRATION 20 CFR Part 404 [Docket No. SSA-2006-0154] RIN 0960-AF78 Entitlement and Termination Requirements for Stepchildren AGENCY: Social Security Administration. ACTION: Final rule. SUMMARY: We are revising our regulations to reflect changes made in the Contract with...

Dexmedetomidine-induced Contraction Involves Phosphorylation of Caldesmon by JNK in Endothelium-denuded Rat Aortas

PubMed Central

Baik, Jiseok; Ok, Seong-Ho; Cho, Hyunhoo; Yu, Jongsun; Kim, Woochan; Nam, In-Koo; Choi, Mun-Jeoung; Lee, Heon-Keun; Sohn, Ju-Tae

2014-01-01

Caldesmon, an inhibitory actin binding protein, binds to actin and inhibits actin-myosin interactions, whereas caldesmon phosphorylation reverses the inhibitory effect of caldesmon on actin-myosin interactions, potentially leading to enhanced contraction. The goal of this study was to investigate the cellular signaling pathway responsible for caldesmon phosphorylation, which is involved in the regulation of the contraction induced by dexmedetomidine (DMT), an alpha-2 adrenoceptor agonist, in endothelium-denuded rat aortas. SP600125 (a c-Jun NH2-terminal kinase [JNK] inhibitor) dose-response curves were generated in aortas that were pre-contracted with DMT or phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator. Dose-response curves to the PKC inhibitor chelerythrine were generated in rat aortas pre-contracted with DMT. The effects of SP600125 and rauwolscine (an alpha-2 adrenoceptor inhibitor) on DMT-induced caldesmon phosphorylation in rat aortic vascular smooth muscle cells (VSMCs) were investigated by western blot analysis. PDBu-induced caldesmon and DMT-induced PKC phosphorylation in rat aortic VSMCs was investigated by western blot analysis. The effects of GF109203X (a PKC inhibitor) on DMT- or PDBu-induced JNK phosphorylation in VSMCs were assessed. SP600125 resulted in the relaxation of aortas that were pre-contracted with DMT or PDBu, whereas rauwolscine attenuated DMT-induced contraction. Chelerythrine resulted in the vasodilation of aortas pre-contracted with DMT. SP600125 and rauwolscine inhibited DMT-induced caldesmon phosphorylation. Additionally, PDBu induced caldesmon phosphorylation, and GF109203X attenuated the JNK phosphorylation induced by DMT or PDBu. DMT induced PKC phosphorylation in rat aortic VSMCs. These results suggest that alpha-2 adrenoceptor-mediated, DMT-induced contraction involves caldesmon phosphorylation that is mediated by JNK phosphorylation by PKC. PMID:25332685

How to Fund Cancellation Ceilings on Multiyear Defense Contracts: A Risk Pooling Alternative

DTIC Science & Technology

1985-01-01

R t- Government faces a termination liability after the first year of the contract for EOQ material. This causes a need for higher authorizations...le items to the Defense inventory. EOQ liability on multiyear programs is currently fully funded to guarantee delivery of all prior- year systems...ýach program years’ buy of systems and the entire EOQ liability each year. -- Best satisfies Congress’ desire for protection against long-term

12 CFR 956.6 - Use of hedging instruments.

Code of Federal Regulations, 2011 CFR

2011-01-01

...; (iii) A description of early termination pricing and methodology, with the methodology reflecting a... International Swaps and Derivatives Association, Inc. language relative to early termination pricing and... obtained prior to the transfer of an agreement or contract by a counterparty. [66 FR 8321, Jan. 30, 2001] ...

A Skeletal, Gas Phase, Finite Rate, Chemical Kinetics Mechanism for Modeling the Deflagration of Ammonium Perchlorate - Hydroxyl-Terminated Polybutadiene Composite Propellants

DTIC Science & Technology

2016-04-01

the Deflagration of Ammonium Perchlorate— Hydroxyl-Terminated Polybutadiene Composite Propellants by Chiung-Chu Chen and Michael McQuaid...for Modeling the Deflagration of Ammonium Perchlorate— Hydroxyl-Terminated Polybutadiene Composite Propellants by Chiung-Chu Chen and Michael...Ammonium Perchlorate—Hydroxyl-Terminated Polybutadiene Composite Propellants 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

48 CFR 47.303-15 - F.o.b. designated air carrier's terminal, point of exportation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false F.o.b. designated air... Contracts 47.303-15 F.o.b. designated air carrier's terminal, point of exportation. (a) Explanation of delivery term. F.o.b. designated air carrier's terminal, point of exportation means free of expense to the...

48 CFR 47.303-16 - F.o.b. designated air carrier's terminal, point of importation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false F.o.b. designated air... Contracts 47.303-16 F.o.b. designated air carrier's terminal, point of importation. (a) Explanation of delivery term. F.o.b. designated air carrier's terminal, point of importation means free of expense to the...

48 CFR 49.103 - Methods of settlement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Methods of settlement. 49... MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.103 Methods of settlement. Settlement of terminated... subpart 49.3), or (d) a combination of these methods. When possible, the TCO should negotiate a fair and...

48 CFR 49.103 - Methods of settlement.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Methods of settlement. 49... MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.103 Methods of settlement. Settlement of terminated... subpart 49.3), or (d) a combination of these methods. When possible, the TCO should negotiate a fair and...

77 FR 8837 - Termination of the Department of Defense Web-Based TRICARE Assistance Program Demonstration

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... DEPARTMENT OF DEFENSE Office of the Secretary Termination of the Department of Defense Web-Based..., entitled Web-Based TRICARE Assistance Program (TRIAP). The demonstration project uses existing health care support contracts (HCSC) to allow web-based behavioral health and related services including non-medical...

If You Ax the Superintendent, Don't Chop Off Your Vital Options.

ERIC Educational Resources Information Center

Zakariya, Sally Banks

1984-01-01

The employment contract is the key item in superintendent firing, and thus, it should include provisions for termination. Terminations can misfire if the board does not carry out contractual obligations. Eight points of advice are included for boards that are contemplating firing a superintendent. (MD)

14 CFR § 1260.76 - Termination and enforcement.

Code of Federal Regulations, 2014 CFR

2014-01-01

... situations that cannot be handled any other way (see § 1260.160). (b) The Director, Contract Management..., suspensions, determinations of ineligibility, and voluntary exclusions of persons in accordance with 2 CFR 180...-responsive organizations. Special condition at § 1260.56 allows NASA to suspend or terminate advance payments...

14 CFR 1260.76 - Termination and enforcement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... cannot be handled any other way (see § 1260.160). (b) The Director, Contract Management Division, shall..., determinations of ineligibility, and voluntary exclusions of persons in accordance with 2 CFR 180.505. (c... organizations. Special condition at § 1260.56 allows NASA to suspend or terminate advance payments under an...

14 CFR 1260.76 - Termination and enforcement.

Code of Federal Regulations, 2011 CFR

2011-01-01

... cannot be handled any other way (see § 1260.160). (b) The Director, Contract Management Division, shall..., determinations of ineligibility, and voluntary exclusions of persons in accordance with 2 CFR 180.505. (c... organizations. Special condition at § 1260.56 allows NASA to suspend or terminate advance payments under an...

14 CFR 1260.76 - Termination and enforcement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... cannot be handled any other way (see § 1260.160). (b) The Director, Contract Management Division, shall..., determinations of ineligibility, and voluntary exclusions of persons in accordance with 2 CFR 180.505. (c... organizations. Special condition at § 1260.56 allows NASA to suspend or terminate advance payments under an...

14 CFR 1260.76 - Termination and enforcement.

Code of Federal Regulations, 2013 CFR

2013-01-01

... cannot be handled any other way (see § 1260.160). (b) The Director, Contract Management Division, shall..., determinations of ineligibility, and voluntary exclusions of persons in accordance with 2 CFR 180.505. (c... organizations. Special condition at § 1260.56 allows NASA to suspend or terminate advance payments under an...

29 CFR 4041.27 - Notice of annuity information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Notice of annuity information. 4041.27 Section 4041.27... TERMINATION OF SINGLE-EMPLOYER PLANS Standard Termination Process § 4041.27 Notice of annuity information. (a... irrevocable commitments (annuity contracts); (2) Change in identity of insurers. A statement that if the plan...

5-HT4 receptor agonists enhance both cholinergic and nitrergic activities in human isolated colon circular muscle.

PubMed

Cellek, S; John, A K; Thangiah, R; Dass, N B; Bassil, A K; Jarvie, E M; Lalude, O; Vivekanandan, S; Sanger, G J

2006-09-01

Previous studies have demonstrated mixed inhibitory and facilitatory effects of 5-hydroxytryptamine-4 (5-HT(4)) receptor agonists on electrical field stimulation (EFS)-induced responses in human isolated colon. Here we report three types of responses to EFS in human isolated colon circular muscle: monophasic cholinergic contraction during EFS, biphasic response (nitrergic relaxation during EFS followed by cholinergic contraction after termination of EFS) and triphasic response (cholinergic contraction followed by nitrergic relaxation during EFS and a tachykininergic contraction after EFS). The effects of two 5-HT(4) receptor agonists, prucalopride and tegaserod were then investigated on monophasic responses only. Each compound inhibited contractions during EFS in a concentration-dependent manner. In the presence of N(omega)-nitro-l-arginine methyl ester (l-NAME) however, prucalopride and tegaserod enhanced the contractions in a concentration-dependent manner. In strips where the tone was elevated with substance-P and treated with scopolamine, EFS-induced relaxations were enhanced by the two agonists. The above observed effects by the two agonists were abolished by 5-HT(4) receptor antagonist SB-204070. The two agonists did not alter the tone raised by substance-P in the presence of scopolamine and l-NAME and did not affect carbachol-induced contractions in the presence of tetrodotoxin. These results suggest that in the circular muscle of human colon, 5-HT(4) receptor agonists simultaneously facilitate the activity of neurones which release the inhibitory and excitatory neurotransmitters, nitric oxide and acetylcholine respectively.

48 CFR 245.7307-2 - Justification.

Code of Federal Regulations, 2010 CFR

2010-10-01

... terminated research and development contracts with educational institutions; (2) No acceptable bids received under an advertised competitive sale; (3) Property value so small that anticipated proceeds would not...

Synaptic activity-related classical protein kinase C isoform localization in the adult rat neuromuscular synapse.

PubMed

Besalduch, Núria; Tomàs, Marta; Santafé, Manel M; Garcia, Neus; Tomàs, Josep; Lanuza, Maria Angel

2010-01-10

Protein kinase C (PKC) is essential for signal transduction in a variety of cells, including neurons and myocytes, and is involved in both acetylcholine release and muscle fiber contraction. Here, we demonstrate that the increases in synaptic activity by nerve stimulation couple PKC to transmitter release in the rat neuromuscular junction and increase the level of alpha, betaI, and betaII isoforms in the membrane when muscle contraction follows the stimulation. The phosphorylation activity of these classical PKCs also increases. It seems that the muscle has to contract in order to maintain or increase classical PKCs in the membrane. We use immunohistochemistry to show that PKCalpha and PKCbetaI were located in the nerve terminals, whereas PKCalpha and PKCbetaII were located in the postsynaptic and the Schwann cells. Stimulation and contraction do not change these cellular distributions, but our results show that the localization of classical PKC isoforms in the membrane is affected by synaptic activity.

40 CFR 35.6760 - Enforcement and termination for convenience.

Code of Federal Regulations, 2014 CFR

2014-07-01

... OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Other Administrative Requirements for Cooperative Agreements § 35.6760...

48 CFR 49.108-3 - Settlement procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT TERMINATION OF CONTRACTS General Principles 49.108-3 Settlement procedure. (a) Contractors shall settle with subcontractors in general conformity with the policies and principles relating to settlement...

48 CFR 245.7001 - Selection, appointment, and termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Appointment of Property... officers, the appointment authority shall consider experience, training, education, business acumen, judgment, character, and ethics. ...

Involvement of the Tyr kinase/JNK pathway in carbachol-induced bronchial smooth muscle contraction in the rat.

PubMed

Sakai, Hiroyasu; Watanabe, Yu; Honda, Mai; Tsuiki, Rika; Ueda, Yusuke; Nagai, Yuki; Narita, Minoru; Misawa, Miwa; Chiba, Yoshihiko

2013-05-01

Tyrosine (Tyr) kinases and mitogen-activated protein kinases have been thought to participate in the contractile response in various smooth muscles. The aim of the current study was to investigate the involvement of the Tyr kinase pathway in the contraction of bronchial smooth muscle. Ring preparations of bronchi isolated from rats were suspended in an organ bath. Isometric contraction of circular smooth muscle was measured. Immunoblotting was used to examine the phosphorylation of c-Jun N-terminal kinasess (JNKs) in bronchial smooth muscle. To examine the role of mitogen-activated protein kinase(s) in bronchial smooth muscle contraction, the effects of MPAK inhibitors were investigated in this study. The contraction induced by carbachol (CCh) was significantly inhibited by pretreatment with selective Tyr kinase inhibitors (genistein and ST638, n = 6, respectively), and a JNK inhibitor (SP600125, n = 6). The contractions induced by high K depolarization (n = 4), orthovanadate (a potent Tyr phosphatase inhibitor) and sodium fluoride (a G protein activator; NaF) were also significantly inhibited by selective Tyr kinase inhibitors and a JNK inhibitor (n = 4, respectively). However, the contraction induced by calyculin-A was not affected by SP600125. On the other hand, JNKs were phosphorylated by CCh (2.2 ± 0,4 [mean±SEM] fold increase). The JNK phosphorylation induced by CCh was significantly inhibited by SP600125 (n = 4). These findings suggest that the Tyr kinase/JNK pathway may play a role in bronchial smooth muscle contraction. Strategies to inhibit JNK activation may represent a novel therapeutic approach for diseases involving airway obstruction, such as asthma and chronic obstructive pulmonary disease.

39 CFR 601.104 - Postal purchasing authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

...: INTELLECTUAL PROPERTY RIGHTS OTHER THAN PATENTS PURCHASING OF PROPERTY AND SERVICES § 601.104 Postal purchasing..., or terminating any contract regarding the acquisition of property, services, and related purchasing...

48 CFR 49.002 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

... completed articles or work at the contract price and amounts for the settlement of subcontractor settlement proposals. Credits for retention or other disposal of termination inventory and amounts for advance or...

Suppression of Peripheral Sympathetic Activity Underlies Protease-Activated Receptor 2-Mediated Hypotension

PubMed Central

Kim, Young-Hwan; Ahn, Duck-Sun; Joeng, Ji-Hyun

2014-01-01

Protease-activated receptor (PAR)-2 is expressed in endothelial cells and vascular smooth muscle cells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vascular tone. Although some reports have suggested involvement of a neurogenic mechanism in PAR-2-induced hypotension, the accurate mechanism remains to be elucidated. To examine this possibility, we investigated the effect of PAR-2 activation on smooth muscle contraction evoked by electrical field stimulation (EFS) in the superior mesenteric artery. In the present study, PAR-2 agonists suppressed neurogenic contractions evoked by EFS in endothelium-denuded superior mesenteric arterial strips but did not affect contraction elicited by the external application of noradrenaline (NA). However, thrombin, a potent PAR-1 agonist, had no effect on EFS-evoked contraction. Additionally, ω-conotoxin GVIA (CgTx), a selective N-type Ca2+ channel (ICa-N) blocker, significantly inhibited EFS-evoked contraction, and this blockade almost completely occluded the suppression of EFS-evoked contraction by PAR-2 agonists. Finally, PAR-2 agonists suppressed the EFS-evoked overflow of NA in endothelium-denuded rat superior mesenteric arterial strips and this suppression was nearly completely occluded by ω-CgTx. These results suggest that activation of PAR-2 may suppress peripheral sympathetic outflow by modulating activity of ICa-N which are located in peripheral sympathetic nerve terminals, which results in PAR-2-induced hypotension. PMID:25598663

26 CFR 1.148-4A - Yield on an issue of bonds.

Code of Federal Regulations, 2013 CFR

2013-04-01

... are determined as of the date the parties enter into the contract. (ii) Anticipatory hedges—(A) In... close (terminate) an anticipatory hedge of that bond do not prevent the hedge from satisfying the... received by the issuer in connection with the issuance of the hedged bonds to terminate an anticipatory...

26 CFR 1.148-4A - Yield on an issue of bonds.

Code of Federal Regulations, 2011 CFR

2011-04-01

... are determined as of the date the parties enter into the contract. (ii) Anticipatory hedges—(A) In... close (terminate) an anticipatory hedge of that bond do not prevent the hedge from satisfying the... received by the issuer in connection with the issuance of the hedged bonds to terminate an anticipatory...

26 CFR 1.148-4A - Yield on an issue of bonds.

Code of Federal Regulations, 2010 CFR

2010-04-01

... are determined as of the date the parties enter into the contract. (ii) Anticipatory hedges—(A) In... close (terminate) an anticipatory hedge of that bond do not prevent the hedge from satisfying the... received by the issuer in connection with the issuance of the hedged bonds to terminate an anticipatory...

26 CFR 1.148-4A - Yield on an issue of bonds.

Code of Federal Regulations, 2012 CFR

2012-04-01

... are determined as of the date the parties enter into the contract. (ii) Anticipatory hedges—(A) In... close (terminate) an anticipatory hedge of that bond do not prevent the hedge from satisfying the... received by the issuer in connection with the issuance of the hedged bonds to terminate an anticipatory...

26 CFR 1.148-4A - Yield on an issue of bonds.

Code of Federal Regulations, 2014 CFR

2014-04-01

... are determined as of the date the parties enter into the contract. (ii) Anticipatory hedges—(A) In... close (terminate) an anticipatory hedge of that bond do not prevent the hedge from satisfying the... received by the issuer in connection with the issuance of the hedged bonds to terminate an anticipatory...

42 CFR 405.445 - Renewal and early termination of opt-out.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Renewal and early termination of opt-out. 405.445 Section 405.445 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Private Contracts § 405.445...

75 FR 28228 - Federal Acquisition Regulation; FAR Case 2009-031, Terminating Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... alternative clauses that can be used for terminations up to the simplified acquisition threshold. The language... ADMINISTRATION 48 CFR Part 49 [FAR Case 2009-031; Docket 2010-0090, Sequence 1] RIN 9000-AL56 Federal Acquisition...: The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) are...

76 FR 21041 - Information about the DOL Notification Process for Worker Abandonment, or Termination for Cause...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... employment, or was terminated for cause before the end of the work contract period. DATES: This Notice is... employment fails to report for work at the regularly scheduled time for 5 consecutive work days without... DEPARTMENT OF LABOR Employment and Training Administration Information about the DOL Notification...

NASA procurement report, FY 1993

NASA Technical Reports Server (NTRS)

1993-01-01

Summary data on all NASA procurement actions and detailed information on contracts, grants, agreements, and other procurements over $25,000 awarded by NASA during fiscal year 1993. The dollar value on procurements over $25,000 amounted to 97 percent of the total dollar value of procurement actions completed during fiscal year 1993. However, these larger procurements accounted for only 29 percent of the total actions. Procurement action, as used in this report, means contractural actions to obtain supplies, services, or construction which increase or decrease funds. A procurement action thus may be a new procurement, or modifications such as supplemental agreements, change orders, or terminations to an existing contract that change the total amount of funds obligated. An obligation is a contractual commitment to pay for supplies or services that are specified in the contract.

48 CFR 47.301-1 - Responsibilities of contracting officers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... termination, including the movement of property by the Government to and from contractors' plants. (b... the use of special equipment, excess blocking and bracing material, or circuitous routing. ...

48 CFR 22.1703 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Procuring commercial sex acts during the period of performance of the contract; or (3) Using forced labor in... them for violations; and (c) Impose suitable remedies, including termination, on contractors that fail...

48 CFR 22.1703 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Procuring commercial sex acts during the period of performance of the contract; or (3) Using forced labor in... them for violations; and (c) Impose suitable remedies, including termination, on contractors that fail...

48 CFR 22.1703 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Procuring commercial sex acts during the period of performance of the contract; or (3) Using forced labor in... them for violations; and (c) Impose suitable remedies, including termination, on contractors that fail...

48 CFR 22.1703 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) Procuring commercial sex acts during the period of performance of the contract; or (3) Using forced labor in... them for violations; and (c) Impose suitable remedies, including termination, on contractors that fail...

48 CFR 22.1703 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Procuring commercial sex acts during the period of performance of the contract; or (3) Using forced labor in... them for violations; and (c) Impose suitable remedies, including termination, on contractors that fail...

24 CFR 221.753 - Termination of mortgage insurance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES LOW COST AND MODERATE INCOME MORTGAGE INSURANCE-SAVINGS CLAUSE Contract Rights and Obligations...

Slow wave contraction frequency plateaus in the small intestine are composed of discrete waves of interval increase associated with dislocations.

PubMed

Parsons, Sean P; Huizinga, Jan D

2018-06-03

What is the central question of this study? What is the nature of slow wave driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaus are composed of discrete waves of increased interval, each wave associated with a contraction dislocation. Smooth frequency gradients are generated by localised neural modulation of wave frequency, leading to functionally important wave turbulence. Both patterns are emergent properties of a network of coupled oscillators, the interstitial cells of Cajal. A gut-wide network of interstitial cells of Cajal (ICC) generate electrical oscillations (slow waves) that orchestrate waves of muscle contraction. In the small intestine there is a gradient in slow wave frequency from high at the duodenum to low at the terminal ileum. Time-averaged measurements of frequency have suggested either a smooth or stepped (plateaued) gradient. We measured individual contraction intervals from diameter maps of the mouse small intestine to create interval maps (IMaps). IMaps showed that each frequency plateau was composed of discrete waves of increased interval. Each interval wave originated at a terminating contraction wave, a "dislocation", at the plateau's proximal boundary. In a model chain of coupled phase oscillators, interval wave frequency increased as coupling decreased or as the natural frequency gradient or noise increased. Injuring the intestine at a proximal point to destroy coupling, suppressed distal steps which then reappeared with gap junction block by carbenoxolone. This lent further support to our previous hypothesis that lines of dislocations were fixed by points of low coupling strength. Dislocations induced by electrical field pulses in the intestine and by equivalent phase shift in the model, were associated with interval waves. When the enteric nervous system was active, IMaps showed a chaotic, turbulent pattern of interval change with no frequency steps or plateaus. This probably resulted from local, stochastic release of neurotransmitters. Plateaus, dislocations, interval waves and wave turbulence arise from a dynamic interplay between natural frequency and coupling in the ICC network. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

48 CFR 49.001 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TERMINATION OF CONTRACTS 49.001 Definitions. As used in this part— Other work means any current or scheduled... classification. The final phase of the plant clearance period means that period after receipt of acceptable...

48 CFR 49.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TERMINATION OF CONTRACTS 49.001 Definitions. As used in this part— Other work means any current or scheduled... classification. The final phase of the plant clearance period means that period after receipt of acceptable...

48 CFR 52.249-1 - Termination for Convenience of the Government (Fixed-Price) (Short Form).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Convenience of the Government (Fixed-Price) (Short Form). 52.249-1 Section 52.249-1 Federal Acquisition... (Fixed-Price) (Short Form). As prescribed in 49.502(a)(1), insert the following clause: Termination for Convenience of the Government (Fixed-Price) (Short Form) (APR 1984) The Contracting Officer, by written notice...

48 CFR 52.247-52 - Clearance and Documentation Requirements-Shipments to DOD Air or Water Terminal Transshipment...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Clearance and Documentation Requirements-Shipments to DOD Air or Water Terminal Transshipment Points. 52.247-52 Section 52.247-52 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES...

48 CFR 623.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 623.506...

48 CFR 623.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 623.506...

48 CFR 623.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 623.506...

48 CFR 623.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 623.506...

48 CFR 623.506 - Suspension of payments, termination of contract, and debarment and suspension actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 623.506...

23 CFR 633.101 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... projects, termination of a contract, and implementation of the Clean Air Act and the Federal Water Pollution Control Act, and other provisions as shall from time-to-time be required by law and regulation as...

23 CFR 633.101 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-04-01

... projects, termination of a contract, and implementation of the Clean Air Act and the Federal Water Pollution Control Act, and other provisions as shall from time-to-time be required by law and regulation as...

48 CFR 952.250-70 - Nuclear hazards indemnity agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... obligation under this contract and shall be unaffected by the death, disability, or termination of existence...) Inclusion in subcontracts. The Contractor shall insert this clause in any subcontract which may involve the...

Condensin loaded onto the replication fork barrier site in the rRNA gene repeats during S phase in a FOB1-dependent fashion to prevent contraction of a long repetitive array in Saccharomyces cerevisiae.

PubMed

Johzuka, Katsuki; Terasawa, Masahiro; Ogawa, Hideyuki; Ogawa, Tomoko; Horiuchi, Takashi

2006-03-01

An average of 200 copies of the rRNA gene (rDNA) is clustered in a long tandem array in Saccharomyces cerevisiae. FOB1 is known to be required for expansion/contraction of the repeats by stimulating recombination, thereby contributing to the maintenance of the average copy number. In Deltafob1 cells, the repeats are still maintained without any fluctuation in the copy number, suggesting that another, unknown system acts to prevent repeat contraction. Here, we show that condensin acts together with FOB1 in a functionally complemented fashion to maintain the long tandem repeats. Six condensin mutants possessing severely contracted rDNA repeats were isolated in Deltafob1 cells but not in FOB1+ cells. We also found that the condensin complex associated with the nontranscribed spacer region of rDNA with a major peak coincided with the replication fork barrier (RFB) site in a FOB1-dependent fashion. Surprisingly, condensin association with the RFB site was established during S phase and was maintained until anaphase. These results indicate that FOB1 plays a novel role in preventing repeat contraction by regulating condensin association and suggest a link between replication termination and chromosome condensation and segregation.

Summary data on all NASA procurement actions

NASA Technical Reports Server (NTRS)

1992-01-01

This report presents summary data on all NASA procurement actions and detailed information on contracts, grants, agreements, and other procurements over $25,000 awarded by NASA during Fiscal Year 1992 (FY-92). The dollar value on procurements over $25,000 amounted to 97 percent of the total dollar value of procurement actions completed during FY-92. However, these larger procurements accounted for only 28 percent of the total actions. Procurement action, as used in this report, means contractual actions to obtain supplies, services, or construction which increase or decrease funds. A procurement action thus may be a new procurement or modifications such as supplemental agreements, change orders, or terminations to an existing contract that change the total amount of funds obligated. An obligation is a contractual commitment to pay for supplies or services that are specified in the contract.

A dihydropyridine receptor alpha1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor.

PubMed

Cui, Yanfang; Tae, Han-Shen; Norris, Nicole C; Karunasekara, Yamuna; Pouliquin, Pierre; Board, Philip G; Dulhunty, Angela F; Casarotto, Marco G

2009-03-01

The II-III loop of the dihydropyridine receptor (DHPR) alpha(1s) subunit is a modulator of the ryanodine receptor (RyR1) Ca(2+) release channel in vitro and is essential for skeletal muscle contraction in vivo. Despite its importance, the structure of this loop has not been reported. We have investigated its structure using a suite of NMR techniques which revealed that the DHPR II-III loop is an intrinsically unstructured protein (IUP) and as such belongs to a burgeoning structural class of functionally important proteins. The loop does not possess a stable tertiary fold: it is highly flexible, with a strong N-terminal helix followed by nascent helical/turn elements and unstructured segments. Its residual structure is loosely globular with the N and C termini in close proximity. The unstructured nature of the II-III loop may allow it to easily modify its interaction with RyR1 following a surface action potential and thus initiate rapid Ca(2+) release and contraction. The in vitro binding partner for the II-III was investigated. The II-III loop interacts with the second of three structurally distinct SPRY domains in RyR1, whose function is unknown. This interaction occurs through two preformed N-terminal alpha-helical regions and a C-terminal hydrophobic element. The A peptide corresponding to the helical N-terminal region is a common probe of RyR function and binds to the same SPRY domain as the full II-III loop. Thus the second SPRY domain is an in vitro binding site for the II-III loop. The possible in vivo role of this region is discussed.

41 CFR 302-9.104 - What may I do if there is no port or terminal at the point of origin and/or destination?

Code of Federal Regulations, 2010 CFR

2010-07-01

... is no port or terminal at the point of origin and/or destination? 302-9.104 Section 302-9.104 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES TRANSPORTATION AND... Transportation General § 302-9.104 What may I do if there is no port or terminal at the point of origin and/or...

11. "INSTRUMENTATION AND CONTROL SYSTEMS, EQUIPMENT LOCATION, TEST STAND TERMINAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. "INSTRUMENTATION AND CONTROL SYSTEMS, EQUIPMENT LOCATION, TEST STAND TERMINAL ROOM, PLANS AND SECTION." Specifications No. ENG-04-353-55-72; Drawing No. 60-0912; sheet 106 of 148; file no. 1321/57. Stamped: RECORD DRAWING - AS CONSTRUCTED. Below stamp: Contract no. 4338, no change. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Test Stand 1-A Terminal Room, Test Area 1-120, north end of Jupiter Boulevard, Boron, Kern County, CA

It took two decades for private payor contracts to erode the bottom line: plan on a 2+ year comeback--here's how, Part V.

PubMed

Noyes, Penny

2008-01-01

Parts I through IV of this article series covered getting organized, financial analysis, negotiating strategies, and solutions for a handful of lopsided contract provisions. This last article in the series offers some final contract provisions that if accepted "as is" in the payors' or networks' proposed agreements will afford the payers with too much control over key financial, administrative, and clinical issues related to serving patients covered under the contract. Among those discussed in this article are: medical necessity, confidentiality, term/termination/evergreen, favored nation, products to be included in the agreement, EOB and ID card identifiers, and "drafted jointly" issues. You may not win on all of these, but to not request these changes is an implied acceptance of the agreement terms, perpetuating the unfairness. Ask yourself as you read through this last article, "If my deal-breaker changes are not made, am I ready to walk?" There is no right or wrong answer, but if it is '"yes," then your negotiating power just increased tremendously.

[A photo-optical observation of gallbladder motility in dogs (author's transl)].

PubMed

Kudo, N

1976-03-01

A photo-optical observation on gallbladder motility was made with the 16 mm cine-cholangiography. The subjects studied were thirty two mongrel dogs. The gallbladder was exposed by a short upper midline abdominal incision under pentothal anesthesia. Gallbladder bile was aspirated and contrast medium was given into the bladder, through a transhepatic route. The cine-cholangiography was done by an image intensifier at a speed of one frame every 2 to 4 seconds. The cinefilms taken were observed repeatedly by the screen projection at various speeds. The drawings were made by tracing the outline of the image of the gallbladder on each frame and were overlapped. Moreover, a contraction curve was made by the cholecystometry using of film motion analyzer in every case. At the same time bile flow into the duodenum was recorded to study a relationship between the gallbladder contraction and motility of the terminal common bile duct. The results obtained are as follows: 1. In a resting state any contraction of the gallbladder was not seen during 30 minutes, and a peristalsis-like movements of the neck portion was observed. However, there was not a relationship between the contraction curve of the gallbladder and the bile flow into the duodenum. 2. Immediately after giving Caerulein, the contrast medium injected into the gallbladder was rapidly discharged into the common bile duct by a peristalsis-like movement of the neck. The size of the gallbladder was markedly decreased into three fifths of the initial state three minutes after administration. At the same time contrast medium was continuously discharged into the duodenum. 3. After giving pilocarpine a marked contraction with forceful movement of the neck and body was observed, and the size of the gallbladder was decreased into three quarters ot the initial state. Bile discharge into the duodenum was markedly increased with an active open- and closing movement of the terminal common bile duct.

77 FR 54937 - International Mail Postal Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... United States for recycling, refurbishment, repair, or value-added processing. Notice at 5. \\3\\ The IBRS... to take effect 1 day later, on September 15, 2012, for a period of 1 year, unless terminated earlier...

24 CFR 982.309 - Term of assisted tenancy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... term of the HAP contract begins on the first day of the lease term and ends on the last day of the... assistance for the family. (c) Family responsibility. (1) If the family terminates the lease on notice to the owner, the family must give the PHA a copy of the notice of termination at the same time. Failure to do...

26 CFR 1.936-5 - Intangible property income when an election out is made: Product, business presence, and contract...

Code of Federal Regulations, 2012 CFR

2012-04-01

..., create a material distortion of income. If the Commissioner determines that the taxpayer's grouping is...-programmable, interactive cathode ray tube computer terminals that vary in price. These terminals all interact... section 954(d)(1)(A)) of a bulk pharmaceutical in Puerto Rico from raw materials. S sold the bulk...

26 CFR 1.936-5 - Intangible property income when an election out is made: Product, business presence, and contract...

Code of Federal Regulations, 2013 CFR

2013-04-01

..., create a material distortion of income. If the Commissioner determines that the taxpayer's grouping is...-programmable, interactive cathode ray tube computer terminals that vary in price. These terminals all interact... section 954(d)(1)(A)) of a bulk pharmaceutical in Puerto Rico from raw materials. S sold the bulk...

26 CFR 1.936-5 - Intangible property income when an election out is made: Product, business presence, and contract...

Code of Federal Regulations, 2014 CFR

2014-04-01

..., create a material distortion of income. If the Commissioner determines that the taxpayer's grouping is...-programmable, interactive cathode ray tube computer terminals that vary in price. These terminals all interact... section 954(d)(1)(A)) of a bulk pharmaceutical in Puerto Rico from raw materials. S sold the bulk...

26 CFR 1.936-5 - Intangible property income when an election out is made: Product, business presence, and contract...

Code of Federal Regulations, 2011 CFR

2011-04-01

..., create a material distortion of income. If the Commissioner determines that the taxpayer's grouping is...-programmable, interactive cathode ray tube computer terminals that vary in price. These terminals all interact... section 954(d)(1)(A)) of a bulk pharmaceutical in Puerto Rico from raw materials. S sold the bulk...

Middle ear muscle contractions and their relation to pulse and echo evoked potentials in the bat

NASA Technical Reports Server (NTRS)

Henson, O. W., Jr.; Henson, M. M.

1972-01-01

An analysis is made of pulse and echo orientation cries of the Mustache Bat. That bat's cries are characterized by a long, 60 to 30 msec, pure tone component and brief beginning and terminal FM sweeps. In addition to obvious echo overlap and middle ear muscle contractions, the following are examined: (1) characteristics of pulse- and echo-evoked potential under various conditions, (2) evidence of changes in hearing sensitivity during and after pulse emission, and (3) the role of the middle ear muscles in bringing about these changes.

Sigma receptor ligand N,N'-di-(ortho-tolyl)guanidine inhibits release of acetylcholine in the guinea pig ileum.

PubMed

Cambell, B G; Keana, J F; Weber, E

1991-11-26

The inhibition of stimulated contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation by sigma receptor ligands has been previously described. In this study, the stimulated release of [3H]acetylcholine from cholinergic nerve terminals in this same preparation was monitored in the presence and absence of sigma receptor ligands. N,N'-Di-(orthotolyl)guanidine (DTG) and other compounds selective for the sigma receptor inhibited stimulated [3H]acetylcholine release. These results suggest that their inhibition of stimulated contractions in this preparation was mediated by inhibition of acetylcholine release.

42 CFR 422.752 - Basis for imposing intermediate sanctions and civil money penalties.

Code of Federal Regulations, 2013 CFR

2013-10-01

... with the organization whose medical condition or history indicates a need for substantial future... determination that could lead to a contract termination under 422.510(a), CMS may impose the intermediate...

42 CFR 422.752 - Basis for imposing intermediate sanctions and civil money penalties.

Code of Federal Regulations, 2011 CFR

2011-10-01

... with the organization whose medical condition or history indicates a need for substantial future... determination that could lead to a contract termination under 422.510(a), CMS may impose the intermediate...

42 CFR 422.752 - Basis for imposing intermediate sanctions and civil money penalties.

Code of Federal Regulations, 2012 CFR

2012-10-01

... with the organization whose medical condition or history indicates a need for substantial future... determination that could lead to a contract termination under 422.510(a), CMS may impose the intermediate...

48 CFR 49.603-2 - Fixed-price contracts-partial termination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Contractor transfers, conveys, and assigns to the Government all the right, title, and interest, if any, that... relating to price reductions for defective certified cost or pricing data. (End of agreement) [48 FR 42447...

Annual Procurement Report, Fiscal Year 1997

NASA Technical Reports Server (NTRS)

1997-01-01

This report presents summary data on all NASA procurement actions and detailed information on contracts, grants, agreements, and other procurements over $25,000 awarded by NASA during Fiscal Year 1997. The dollar value on procurements over $25,000 amounted to 98 percent of the total dollar value of procurement actions completed during Fiscal Year 1997. However, these larger procurements accounted for only 43 percent of the total actions. Procurement action, as used in this report means contractual actions to obtain supplies, services or construction which increase or decrease funds. A procurement action thus may be a new procurement or modifications such as supplemental agreements, change orders, or termination's to an existing contract that change the total amount of funds obligated. An obligation is a contractual commitment to pay for supplies or services that are specified in the contract. The Annual Procurement Report is also available via the internet on the Procurement homepage.

Evaluation of agreements between managed care organizations and providers of community-based mental illness and addiction disorder treatments.

PubMed

Rosenbaum, Sara; Mauery, D Richard; Teitelbaum, Joel; Vandivort-Warren, Rita

2002-02-01

To analyze the scope, content, and nature of contracts between managed care organizations (MCOs) and community-based mental illness and addiction disorder treatment and prevention service providers, focusing on implications for managed care policy. Qualitative and quantitative document content analysis. We reviewed and coded 107 provider contracts from 17 states. Data were aggregated on MCO and provider demographics, scope of services, contractual obligations, and financial reimbursement mechanisms. Results were compared with those from a similar study conducted in 1996 with a sample of 50 contracts to identify changes over time. The MCOs purchased relatively few services from providers, omitting many services integral to the proper management of mental illness and addiction disorders. Service duties were often ambiguously described, leading to potentially significant and unanticipated financial risk for providers. The MCOs exert strong control over treatment decision making. Capitation and other risk-based payment arrangements are increasingly common, although most continue to use fee-for-service reimbursement methods. Contracts are structured to remove provider bargaining power; they allow MCOs to unilaterally amend all provisions on notice and without negotiation and permit termination "at will." Managed care contracts favor the needs of the managed care industry and are constructed to (1) shift significant amounts of financial risk onto providers and (2) manage and restrain providers' choices over the use of benefits through close oversight, financial controls, and incentives. Because a signed contract is a precondition to access to patients and insurance revenues, health professionals must sign them and indicate a general inability to negotiate their terms.

A Lipid Emulsion Reverses Toxic-Dose Bupivacaine-Induced Vasodilation during Tyrosine Phosphorylation-Evoked Contraction in Isolated Rat Aortae.

PubMed

Ok, Seong-Ho; Lee, Soo Hee; Kwon, Seong-Chun; Choi, Mun Hwan; Shin, Il-Woo; Kang, Sebin; Park, Miyeong; Hong, Jeong-Min; Sohn, Ju-Tae

2017-02-13

The goal of this in vitro study was to examine the effect of a lipid emulsion on toxic-dose bupivacaine-induced vasodilation in a model of tyrosine phosphatase inhibitor sodium orthovanadate-induced contraction in endothelium-denuded rat aortae and to elucidate the associated cellular mechanism. The effect of a lipid emulsion on vasodilation induced by a toxic dose of a local anesthetic during sodium orthovanadate-induced contraction was examined. In addition, the effects of various inhibitors, either bupivacaine alone or a lipid emulsion plus bupivacaine, on protein kinase phosphorylation induced by sodium orthovanadate in rat aortic vascular smooth muscle cells was examined. A lipid emulsion reversed the vasodilation induced by bupivacaine during sodium orthovanadate-induced contraction. The lipid emulsion attenuated the bupivacaine-mediated inhibition of the sodium orthovanadate-induced phosphorylation of protein tyrosine, c-Jun NH₂-terminal kinase (JNK), myosin phosphatase target subunit 1 (MYPT1), phospholipase C (PLC) γ-1 and extracellular signal-regulated kinase (ERK). These results suggest that a lipid emulsion reverses toxic-dose bupivacaine-induced vasodilation during sodium orthovanadate-induced contraction via the activation of a pathway involving either tyrosine kinase, JNK, Rho-kinase and MYPT1 or tyrosine kinase, PLC γ-1 and ERK, and this reversal is associated with the lipid solubility of the local anesthetic and the induction of calcium sensitization.

NASA Glenn Research Center Support of the ASRG Project

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Wong, Wayne A.

2014-01-01

A high efficiency radioisotope power system is being developed for long-duration NASA space science missions. The U.S. Department of Energy (DOE) managed a flight contract with Lockheed Martin Space Systems Company (LMSSC) to build Advanced Stirling Radioisotope Generators (ASRGs), with support from NASA Glenn Research Center (GRC). Sunpower Inc. held two parallel contracts to produce Advanced Stirling Convertors (ASCs), one with DOELockheed Martin to produce ASC-F flight units, and one with GRC for the production of ASC-E3 engineering unit pathfinders that are built to the flight design. In support of those contracts, GRC provided testing, materials expertise, government furnished equipment, inspections, and related data products to DOELockheed Martin and Sunpower. The technical support includes material evaluations, component tests, convertor characterization, and technology transfer. Material evaluations and component tests have been performed on various ASC components in order to assess potential life-limiting mechanisms and provide data for reliability models. Convertor level tests have been used to characterize performance under operating conditions that are representative of various mission conditions. Technology transfers enhanced contractor capabilities for specialized production processes and tests. Despite termination of flight ASRG contract, NASA continues to develop the high efficiency ASC conversion technology under the ASC-E3 contract. This paper describes key government furnished services performed for ASRG and future tests used to provide data for ongoing reliability assessments.

A Lipid Emulsion Reverses Toxic-Dose Bupivacaine-Induced Vasodilation during Tyrosine Phosphorylation-Evoked Contraction in Isolated Rat Aortae

PubMed Central

Ok, Seong-Ho; Lee, Soo Hee; Kwon, Seong-Chun; Choi, Mun Hwan; Shin, Il-Woo; Kang, Sebin; Park, Miyeong; Hong, Jeong-Min; Sohn, Ju-Tae

2017-01-01

The goal of this in vitro study was to examine the effect of a lipid emulsion on toxic-dose bupivacaine-induced vasodilation in a model of tyrosine phosphatase inhibitor sodium orthovanadate-induced contraction in endothelium-denuded rat aortae and to elucidate the associated cellular mechanism. The effect of a lipid emulsion on vasodilation induced by a toxic dose of a local anesthetic during sodium orthovanadate-induced contraction was examined. In addition, the effects of various inhibitors, either bupivacaine alone or a lipid emulsion plus bupivacaine, on protein kinase phosphorylation induced by sodium orthovanadate in rat aortic vascular smooth muscle cells was examined. A lipid emulsion reversed the vasodilation induced by bupivacaine during sodium orthovanadate-induced contraction. The lipid emulsion attenuated the bupivacaine-mediated inhibition of the sodium orthovanadate-induced phosphorylation of protein tyrosine, c-Jun NH2-terminal kinase (JNK), myosin phosphatase target subunit 1 (MYPT1), phospholipase C (PLC) γ-1 and extracellular signal-regulated kinase (ERK). These results suggest that a lipid emulsion reverses toxic-dose bupivacaine-induced vasodilation during sodium orthovanadate-induced contraction via the activation of a pathway involving either tyrosine kinase, JNK, Rho-kinase and MYPT1 or tyrosine kinase, PLC γ-1 and ERK, and this reversal is associated with the lipid solubility of the local anesthetic and the induction of calcium sensitization. PMID:28208809

Welfare Reform and Addiction: A Priori Hypotheses, Post Hoc Explorations, and Assisted Sensemaking in Evaluating the Effects of Terminating Benefits for Chronic Substance Abusers

ERIC Educational Resources Information Center

Orwin, Robert G.; Campbell, Bernadette; Campbell, Kevin; Krupski, Antoinette

2004-01-01

The passage of the Contract with America Advancement Act terminated the Social Security Administrations Disability Insurance and Supplemental Security Income benefits for persons diagnosed with drug or alcohol addiction (also known as DA&A recipients), effective January 1, 1997. From an evaluation standpoint, the law created the opportunity…

Novel Methods in Terminal Ballistics and Mechanochemistry of Damage 2. Phenomenological Mechanochemistry of Damage in Solid Brittle Dielectrics

DTIC Science & Technology

2015-09-01

Phenomenological Mechanochemistry of Damage in Solid Brittle Dielectrics by MA Grinfeld Approved for public release...Army Research Laboratory Novel Methods in Terminal Ballistics and Mechanochemistry of Damage 2. Phenomenological Mechanochemistry of Damage...2. Phenomenological Mechanochemistry of Damage in Solid Brittle Dielectrics 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER

42 CFR 423.752 - Basis for imposing intermediate sanctions and civil money penalties.

Code of Federal Regulations, 2011 CFR

2011-10-01

... permitted by this part) by eligible individuals with the organization whose medical condition or history... CMS makes a determination that could lead to a contract termination under 423.509(a), CMS may impose...

42 CFR 423.752 - Basis for imposing intermediate sanctions and civil money penalties.

Code of Federal Regulations, 2014 CFR

2014-10-01

... condition or history indicates a need for substantial future medical services. (5) Misrepresents or... lead to a contract termination under 423.509(a), CMS may impose the intermediate sanctions at 423.750(a...

48 CFR 49.603-1 - Fixed-price contracts-complete termination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Contractor transfers, conveys, and assigns to the Government all the right, title, and interest, if any, that... cost or pricing data. (End of agreement) [48 FR 42447, Sept. 19, 1983, as amended at 60 FR 37773, July...

c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis

DTIC Science & Technology

2015-03-01

1 AWARD NUMBER: W81XWH-12-1-0431 TITLE: “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Sclerosis ” PRINCIPAL...TITLE AND SUBTITLE “c-jun-N-Terminal Kinase (JNK) for the Treatment of Amyotrophic Lateral Scelerosis” 5a. CONTRACT NUMBER 5b. GRANT NUMBER... Lateral   Sclerosis ”   Final  Report:  Project  Period  Sept  2012-­‐Dec  2014     Personnel  List:     Feng,  Yangbo

Evidence for postsynaptic modulation of muscle contraction by a Drosophila neuropeptide.

PubMed

Clark, Julie; Milakovic, Maja; Cull, Amanda; Klose, Markus K; Mercier, A Joffre

2008-07-01

DPKQDFMRFamide, the most abundant FMRFamide-like peptide in Drosophila melanogaster, has been shown previously to enhance contractions of larval body wall muscles elicited by nerve stimulation and to increase excitatory junction potentials (EJPs). The present work investigated the possibility that this peptide can also stimulate muscle contraction by a direct action on muscle fibers. DPKQDFMRFamide induced slow contractions and increased tonus in body wall muscles of Drosophila larvae from which the central nervous system had been removed. The threshold for this effect was approximately 10(-8)M. The increase in tonus persisted in the presence of 7x10(-3)M glutamate, which desensitized postsynaptic glutamate receptors. Thus, the effect on tonus could not be explained by enhanced release of glutamate from synaptic terminals and, thus, may represent a postsynaptic effect. The effect on tonus was abolished in calcium-free saline and by treatment with L-type calcium channel blockers, nifedipine and nicardipine, but not by T-type blockers, amiloride and flunarizine. The present results provide evidence that this Drosophila peptide can act postsynaptically in addition to its apparent presynaptic effects, and that the postsynaptic effect requires influx through L-type calcium channels.

48 CFR 836.606-72 - Contract price.

Code of Federal Regulations, 2014 CFR

2014-10-01

... officer shall, after authorization by the Director, Office of Construction and Facilities Management, the Director, Office of Construction Management, or the facility or VISN director, as appropriate, terminate... Director, Office of Construction and Facilities Management, the Director, Office of Construction Management...