Sample records for control part ii

  1. 40 CFR Appendix B to Subpart A of... - Class II Controlled Substances a

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Class II Controlled Substances a B Appendix B to Subpart A of Part 82 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED..., Subpt. A, App. B Appendix B to Subpart A of Part 82—Class II Controlled Substances a Controlled...

  2. 40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

  3. 40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

  4. 40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

  5. 40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Duty Cycles for Propulsion Marine...) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The...

  6. EBR-II high-ramp transients under computer control

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Forrester, R.J.; Larson, H.A.; Christensen, L.J.

    1983-01-01

    During reactor run 122, EBR-II was subjected to 13 computer-controlled overpower transients at ramps of 4 MWt/s to qualify the facility and fuel for transient testing of LMFBR oxide fuels as part of the EBR-II operational-reliability-testing (ORT) program. A computer-controlled automatic control-rod drive system (ACRDS), designed by EBR-II personnel, permitted automatic control on demand power during the transients.

  7. AT2 DS II - Accelerator System Design (Part II) - CCC Video Conference

    ScienceCinema

    None

    2017-12-09

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  8. 40 CFR Appendix B to Subpart A of... - Class II Controlled Substances a

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Class II Controlled Substances a B..., Subpt. A, App. B Appendix B to Subpart A of Part 82—Class II Controlled Substances a Controlled... the highest ODP, and the lower value is the estimate of the ODP of the isomer with the lowest ODP...

  9. Antigenicity of mesenchymal stem cells in an inflamed joint environment.

    PubMed

    Hill, Jacqueline A; Cassano, Jennifer M; Goodale, Margaret B; Fortier, Lisa A

    2017-07-01

    OBJECTIVE To determine whether major histocompatability complex (MHC) class II expression in equine mesenchymal stem cells (MSCs) changes with exposure to a proinflammatory environment reflective of an inflamed joint. SAMPLE Cryopreserved bone marrow-derived MSCs from 12 horses and cartilage and synovium samples from 1 horse euthanized for reasons other than lameness. PROCEDURES In part 1 of a 3-part study, the suitability of a quantitative reverse transcriptase PCR (qRT-PCR) assay for measurement of MHC class II expression in MSCs following stimulation with interferon (IFN)-γ was assessed. In part 2, synoviocyte-cartilage cocultures were or were not stimulated with interleukin (IL)-1β (10 ng/mL) to generate conditioned media that did and did not (control) mimic an inflamed joint environment. In part 3, a qRT-PCR assay was used to measure MSC MHC class II expression after 96 hours of incubation with 1 of 6 treatments (control-conditioned medium, IL-1β-conditioned medium, and MSC medium alone [untreated control] or with IL-1β [10 ng/mL], tumor necrosis factor-α [10 ng/mL], or IFN-γ [100 ng/mL]). RESULTS The qRT-PCR assay accurately measured MHC class II expression. Compared with MHC class II expression for MSCs exposed to the untreated control medium, that for MSCs exposed to IL-1β was decreased, whereas that for MSCs exposed to IFN-γ was increased. Neither the control-conditioned nor tumor necrosis factor-α medium altered MHC class II expression. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that MSC exposure to proinflammatory cytokine IL-1β decreased MHC class II expression and antigenicity. Treatment of inflamed joints with allogeneic MSCs might not be contraindicated, but further investigation is warranted.

  10. Operational Control Procedures for the Activated Sludge Process, Part I - Observations, Part II - Control Tests.

    ERIC Educational Resources Information Center

    West, Alfred W.

    This is the first in a series of documents developed by the National Training and Operational Technology Center describing operational control procedures for the activated sludge process used in wastewater treatment. Part I of this document deals with physical observations which should be performed during each routine control test. Part II…

  11. 14 CFR 61.5 - Certificates and ratings issued under this part.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-control aircraft. (2) Airplane class ratings— (i) Single-engine land. (ii) Multiengine land. (iii) Single-engine sea. (iv) Multiengine sea. (3) Rotorcraft class ratings— (i) Helicopter. (ii) Gyroplane. (4) Lighter-than-air class ratings— (i) Airship. (ii) Balloon. (5) Weight-shift-control aircraft class ratings...

  12. 14 CFR 61.5 - Certificates and ratings issued under this part.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-control aircraft. (2) Airplane class ratings— (i) Single-engine land. (ii) Multiengine land. (iii) Single-engine sea. (iv) Multiengine sea. (3) Rotorcraft class ratings— (i) Helicopter. (ii) Gyroplane. (4) Lighter-than-air class ratings— (i) Airship. (ii) Balloon. (5) Weight-shift-control aircraft class ratings...

  13. 14 CFR 61.5 - Certificates and ratings issued under this part.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-control aircraft. (2) Airplane class ratings— (i) Single-engine land. (ii) Multiengine land. (iii) Single-engine sea. (iv) Multiengine sea. (3) Rotorcraft class ratings— (i) Helicopter. (ii) Gyroplane. (4) Lighter-than-air class ratings— (i) Airship. (ii) Balloon. (5) Weight-shift-control aircraft class ratings...

  14. 76 FR 24872 - California State Nonroad Engine and Vehicle Pollution Control Standards; Authorization of Tier II...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... Pollution Control Standards; Authorization of Tier II Marine Inboard/Sterndrive Spark Ignition Engine... for its second tier (``Tier II'') of emission standards for new marine inboard/sterndrive spark... record of this Marine Engine Authorization Request docket. Although a part of the official docket, the...

  15. 77 FR 43196 - Minimum Internal Control Standards and Technical Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... NATIONAL INDIAN GAMING COMMISSION 25 CFR Parts 543 and 547 Minimum Internal Control Standards [email protected] . SUPPLEMENTARY INFORMATION: Part 543 addresses minimum internal control standards (MICS) for Class II gaming operations. The regulations require tribes to establish controls and implement...

  16. Higher Education in Poland Part II: Rules of Admissions, Student Activities, and Curriculums. Bulletin, 1964, No. 22. OE-14099

    ERIC Educational Resources Information Center

    Rosen, Seymour M.; Apanasewicz, Nellie

    1964-01-01

    The previously published "Higher Education in Poland, Part I: Organization and Administration," and the present volume constitute an Office of Education study on the Polish system of higher learning. Part II explains the functioning of Polish institutions under control of the Ministry of Higher Education and other ministries, and…

  17. Control Systems for Information Systems Development Projects (Part I)

    ERIC Educational Resources Information Center

    Dickson, Gary W.

    1970-01-01

    Discusses control of management information systems and finds a similarity in management of research and development activity. Part II will appear in AEDS Journal, Volume 4, number 2, December 1970. (JF)

  18. Detecting Controller Malfunctions in Electromagnetic Environments. Part 1; Modeling and Estimation of Nominal System Function

    NASA Technical Reports Server (NTRS)

    Weinstein, Bernice

    1999-01-01

    A strategy for detecting control law calculation errors in critical flight control computers during laboratory validation testing is presented. This paper addresses Part I of the detection strategy which involves the use of modeling of the aircraft control laws and the design of Kalman filters to predict the correct control commands. Part II of the strategy which involves the use of the predicted control commands to detect control command errors is presented in the companion paper.

  19. Part I: Steady States in Two-Species Particle Aggregation. Part II: Sparse Representations for Multiscale PDE

    DTIC Science & Technology

    2015-03-01

    University of California Los Angeles Part I: Steady States in Two-Species Particle Aggregation Part II: Sparse Representations for Multiscale PDE A ...Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a ...penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE MAR 2015

  20. 77 FR 43711 - The Commerce Control List

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Part 774 The Commerce Control List CFR Correction In Title 15 of the Code of Federal Regulations, Parts 300 to 799, revised as of January... II, in 5E002, after ``Related Controls'' and before ``Items'', add ``Related Definitions: N/A''. [FR...

  1. Sampled Data Adaptive Digital Computer Control of Surface Ship Maneuvers

    DTIC Science & Technology

    1976-06-01

    0.53 feet. Systems fcr which fuel considerations are not a motivating 157 factor lay te designed without this part of the control law ta allow finer...COXXXQXxaQXQ«^2Q£>’^ o>- —,>->>>ozor X < a. Ps4 <i i— « aC _J o < a o-*»-» ujOO • •>- o • •oo«mo z o «j II II ** » < ii ii -^ -* -,-^a:- i—— * O.-IUJ

  2. Experimental Demonstration of Frequency Regulation by Commercial Buildings – Part II: Results and Performance Evaluation

    DOE PAGES

    Vrettos, Evangelos; Kara, Emre Can; MacDonald, Jason; ...

    2016-11-15

    This paper is the second part of a two-part series presenting the results from an experimental demonstration of frequency regulation in a commercial building test facility. We developed relevant building models and designed a hierarchical controller for reserve scheduling, building climate control and frequency regulation in Part I. In Part II, we introduce the communication architecture and experiment settings, and present extensive experimental results under frequency regulation. More specifically, we compute the day-ahead reserve capacity of the test facility under different assumptions and conditions. Furthermore, we demonstrate the ability of model predictive control to satisfy comfort constraints under frequency regulation,more » and show that fan speed control can track the fast-moving RegD signal of the Pennsylvania, Jersey, and Maryland Power Market (PJM) very accurately. In addition, we discuss potential effects of frequency regulation on building operation (e.g., increase in energy consumption, oscillations in supply air temperature, and effect on chiller cycling), and provide suggestions for real-world implementation projects. Our results show that hierarchical control is appropriate for frequency regulation from commercial buildings.« less

  3. 75 FR 55269 - Minimum Internal Control Standards for Class II Gaming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... DEPARTMENT OF THE INTERIOR National Indian Gaming Commission 25 CFR Parts 542 and 543 RIN 3141-AA-37 Minimum Internal Control Standards for Class II Gaming AGENCY: National Indian Gaming Commission. ACTION: Delay of effective date of final rule; request for comments. SUMMARY: The National Indian Gaming...

  4. 40 CFR Appendix I to Part 1068 - Emission-Related Components

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... system. 2. Fuel system. 3. Ignition system. 4. Exhaust gas recirculation systems. II. The following parts.... Crankcase ventilation valves. 3. Sensors. 4. Electronic control units. III. The following parts are...

  5. 40 CFR Appendix I to Part 1068 - Emission-Related Components

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... system. 2. Fuel system. 3. Ignition system. 4. Exhaust gas recirculation systems. II. The following parts.... Crankcase ventilation valves. 3. Sensors. 4. Electronic control units. III. The following parts are...

  6. Starting a hospital-based home health agency: Part II--Key success factors.

    PubMed

    Montgomery, P

    1993-09-01

    In Part II of a three-part series, the financial, technological and legislative issues of a hospital-based home health-agency are discussed. Beginning a home healthcare service requires intensive research to answer key environmental and operational questions--need, competition, financial projections, initial start-up costs and the impact of delayed depreciation. Assessments involving technology, staffing, legislative and regulatory issues can help project service volume, productivity and cost-control.

  7. Born to run: control of transcription elongation by RNA polymerase II.

    PubMed

    Chen, Fei Xavier; Smith, Edwin R; Shilatifard, Ali

    2018-05-08

    The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an integral part of the implementation of gene expression programmes during development. In most metazoans, the majority of transcribed genes exhibit transient pausing of Pol II at promoter-proximal regions, and the release of Pol II into gene bodies is controlled by many regulatory factors that respond to environmental and developmental cues. Misregulation of the elongation stage of transcription is implicated in cancer and other human diseases, suggesting that mechanistic understanding of transcription elongation control is therapeutically relevant. In this Review, we discuss the features, establishment and maintenance of Pol II pausing, the transition into productive elongation, the control of transcription elongation by enhancers and by factors of other cellular processes, such as topoisomerases and poly(ADP-ribose) polymerases (PARPs), and the potential of therapeutic targeting of the elongation stage of transcription by Pol II.

  8. 40 CFR 52.74 - Original identification of plan section.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Governor of Alaska on January 18, 1980 as follows: Volume II. Analysis of Problems, Control Actions Section... requirements of Air Quality Monitoring, 40 CFR part 58, subpart C, § 58.20, as follows: Volume II. Analysis of Problems, Control Actions Section V. Ambient Air Monitoring A. Purpose C. Air Monitoring Network E. Annual...

  9. 40 CFR 52.70 - Identification of plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... submitted by the Governor of Alaska on January 18, 1980 as follows: Volume II. Analysis of Problems, Control... requirements of Air Quality Monitoring, 40 CFR part 58, subpart C, § 58.20, as follows: Volume II. Analysis of Problems, Control Actions Section V. Ambient Air Monitoring A. Purpose C. Air Monitoring Network E. Annual...

  10. 14 CFR Appendix A to Part 43 - Major Alterations, Major Repairs, and Preventive Maintenance

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... alterations: (i) Changes in blade design. (ii) Changes in hub design. (iii) Changes in the governor or control... alterations: (i) Wings. (ii) Tail surfaces. (iii) Fuselage. (iv) Engine mounts. (v) Control system. (vi... the basic design of the fuel, oil, cooling, heating, cabin pressurization, electrical, hydraulic, de...

  11. 14 CFR Appendix A to Part 43 - Major Alterations, Major Repairs, and Preventive Maintenance

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... alterations: (i) Changes in blade design. (ii) Changes in hub design. (iii) Changes in the governor or control... alterations: (i) Wings. (ii) Tail surfaces. (iii) Fuselage. (iv) Engine mounts. (v) Control system. (vi... the basic design of the fuel, oil, cooling, heating, cabin pressurization, electrical, hydraulic, de...

  12. 14 CFR Appendix A to Part 43 - Major Alterations, Major Repairs, and Preventive Maintenance

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... alterations: (i) Changes in blade design. (ii) Changes in hub design. (iii) Changes in the governor or control... alterations: (i) Wings. (ii) Tail surfaces. (iii) Fuselage. (iv) Engine mounts. (v) Control system. (vi... the basic design of the fuel, oil, cooling, heating, cabin pressurization, electrical, hydraulic, de...

  13. 14 CFR Appendix A to Part 43 - Major Alterations, Major Repairs, and Preventive Maintenance

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... alterations: (i) Changes in blade design. (ii) Changes in hub design. (iii) Changes in the governor or control... alterations: (i) Wings. (ii) Tail surfaces. (iii) Fuselage. (iv) Engine mounts. (v) Control system. (vi... the basic design of the fuel, oil, cooling, heating, cabin pressurization, electrical, hydraulic, de...

  14. Medical Devices; Hematology and Pathology Devices; Classification of the Whole Slide Imaging System. Final order.

    PubMed

    2018-01-02

    The Food and Drug Administration (FDA or we) is classifying the whole slide imaging system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the whole slide imaging system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  15. Medical Devices; Clinical Chemistry and Clinical Toxicology Devices; Classification of the Organophosphate Test System. Final order.

    PubMed

    2017-10-18

    The Food and Drug Administration (FDA or we) is classifying the organophosphate test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the organophosphate test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  16. Medical Devices; Hematology and Pathology Devices; Classification of a Cervical Intraepithelial Neoplasia Test System. Final order.

    PubMed

    2018-01-03

    The Food and Drug Administration (FDA or we) is classifying the cervical intraepithelial neoplasia (CIN) test system into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the CIN test system's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  17. 14 CFR 21.303 - Replacement and modification parts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... determination can be made. Statistical quality control procedures may be employed where it is shown that a... AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Approval of Materials, Parts, Processes, and... the configuration of the part; and (ii) Information on dimensions, materials, and processes necessary...

  18. Low Level RF Control for the PIP-II Accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Edelen, J. P.; Chase, B. E.; Cullerton, E.

    The PIP-II accelerator is a proposed upgrade to the Fermilab accelerator complex that will replace the existing, 400 MeV room temperature LINAC with an 800 MeV superconducting LINAC. Part of this upgrade includes a new injection scheme into the booster that levies tight requirements on the LLRF control system for the cavities. In this paper we discuss the challenges of the PIP-II accelerator and the present status of the LLRF system for this project.

  19. Matters of Cost: Part I. Jones Learns about Balance Sheets: Part II. A Look at Budgetary Control: Part III. The Supervisor's "Do-It-Yourself" Series 3.

    ERIC Educational Resources Information Center

    Smith, J. E.; And Others

    This guide, which is intended for new supervisors and managers to use in an independent study setting, deals with costing, balance sheets, and budgetary control. The first section, "Matters of Cost" by J. E. and J. F. Smith, deals with the following topics: profits and productivity, principles of costing, cost control and cost reduction, fixed and…

  20. Globalization in the pharmaceutical industry, Part II.

    PubMed

    Casadio Tarabusi, C; Vickery, G

    1998-01-01

    This is the second of a two-part report on the pharmaceutical industry. Part II begins with a discussion of foreign direct investment and inter-firm networks, which covers international mergers, acquisitions, and minority participation; market shares of foreign-controlled firms; international collaboration agreements (with a special note on agreements in biotechnology); and licensing agreements. The final section of the report covers governmental policies on health and safety regulation, price regulation, industry and technology, trade, foreign investment, protection of intellectual property, and competition.

  1. Guidance, Navigation and Control Digital Emulation Technology Laboratory. Volume 1. Part 2. Task 1: Digital Emulation Technology Laboratory

    DTIC Science & Technology

    1991-09-27

    AD-A241 692 II I] II I11 ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATOIRY REPORT NO. AR-0142-91-001 September 27, 1991... DIGITAL EMULATION TECHNOLOGY LABORATORY Contract No. DASG60-89-C-0142 Sponsored By The United States Army ? trategic Defense Command COMPUTER...ANNUAL REPORT VOLUME 1 PART 2 TASK 1: DIGITAL EMULATION TECHNOLOGY LABORATORY September 27, 1991 Authors Thomas R. Collins and Stephen R. Wachtel

  2. Medical Devices; Hematology and Pathology Devices; Classification of the Flow Cytometric Test System for Hematopoietic Neoplasms. Final order.

    PubMed

    2017-12-27

    The Food and Drug Administration (FDA or we) is classifying the flow cytometric test system for hematopoietic neoplasms into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the flow cytometric test system for hematopoietic neoplasms' classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  3. 40 CFR 55.14 - Requirements that apply to OCS sources located within 25 miles of States' seaward boundaries, by...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... reference to a State or local air pollution control agency or air pollution control officer shall mean EPA or the Administrator, respectively. (2) Any submittal to State or local air pollution control agency...) [Reserved] (2) Alaska. (i) 40 CFR part 52, subpart C. (ii) [Reserved] (3) California. (i) 40 CFR part 52...

  4. Medical Devices; Immunology and Microbiology Devices; Classification of the Assayed Quality Control Material for Clinical Microbiology Assays. Final order.

    PubMed

    2017-07-27

    The Food and Drug Administration (FDA, Agency, or we) is classifying the assayed quality control material for clinical microbiology assays into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the assayed quality control material for clinical microbiology assays' classification. The Agency is classifying the device into class II (special controls) to provide a reasonable assurance of safety and effectiveness of the device.

  5. Tobacco control and gender in Southeast Asia. Part I: Malaysia and the Philippines.

    PubMed

    Morrow, Martha; Barraclough, Simon

    2003-09-01

    In the World Health Organization's Western Pacific Region, being born male is the single greatest risk marker for tobacco use. While the literature demonstrates that risks associated with tobacco use may vary according to sex, gender refers to the socially determined roles and responsibilities of men and women, who initiate, continue and quit using tobacco for complex and often different reasons. Cigarette advertising frequently appeals to gender roles. Yet tobacco control policy tends to be gender-blind. Using a broad gender-sensitivity framework, this contradiction is explored in four Western Pacific countries. Part I of the study discusses issues surrounding gender and tobacco, and analyses developments in Malaysia and the Philippines. Part II deals with Singapore and Vietnam. In all four countries, gender was salient for the initiation and maintenance of smoking, and in Malaysia and the Philippines was highly significant in cigarette promotion. Yet, with a few exceptions, gender was largely unrecognized in control policy. Suggestions for overcoming this weakness in order to enhance tobacco control are made in Part II.

  6. Tunable, Flexible and Efficient Optimization of Control Pulses for Superconducting Qubits, part II - Applications

    NASA Astrophysics Data System (ADS)

    AsséMat, Elie; Machnes, Shai; Tannor, David; Wilhelm-Mauch, Frank

    In part I, we presented the theoretic foundations of the GOAT algorithm for the optimal control of quantum systems. Here in part II, we focus on several applications of GOAT to superconducting qubits architecture. First, we consider a control-Z gate on Xmons qubits with an Erf parametrization of the optimal pulse. We show that a fast and accurate gate can be obtained with only 16 parameters, as compared to hundreds of parameters required in other algorithms. We present numerical evidences that such parametrization should allow an efficient in-situ calibration of the pulse. Next, we consider the flux-tunable coupler by IBM. We show optimization can be carried out in a more realistic model of the system than was employed in the original study, which is expected to further simplify the calibration process. Moreover, GOAT reduced the complexity of the optimal pulse to only 6 Fourier components, composed with analytic wrappers.

  7. Using magnetic levitation for non-destructive quality control of plastic parts.

    PubMed

    Hennek, Jonathan W; Nemiroski, Alex; Subramaniam, Anand Bala; Bwambok, David K; Yang, Dian; Harburg, Daniel V; Tricard, Simon; Ellerbee, Audrey K; Whitesides, George M

    2015-03-04

    Magnetic levitation (MagLev) enables rapid and non-destructive quality control of plastic parts. The feasibility of MagLev as a method to: i) rapidly assess injection-molded plastic parts for defects during process optimization, ii) monitor the degradation of plastics after exposure to harsh environmental conditions, and iii) detect counterfeit polymers by density is demonstrated. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Single Crystal Diffractometry

    NASA Astrophysics Data System (ADS)

    Arndt, U. W.; Willis, B. T. M.

    2009-06-01

    Preface; Acknowledgements; Part I. Introduction; Part II. Diffraction Geometry; Part III. The Design of Diffractometers; Part IV. Detectors; Part V. Electronic Circuits; Part VI. The Production of the Primary Beam (X-rays); Part VII. The Production of the Primary Beam (Neutrons); Part VIII. The Background; Part IX. Systematic Errors in Measuring Relative Integrated Intensities; Part X. Procedure for Measuring Integrated Intensities; Part XI. Derivation and Accuracy of Structure Factors; Part XII. Computer Programs and On-line Control; Appendix; References; Index.

  9. Active Control of Low-Speed Fan Tonal Noise Using Actuators Mounted in Stator Vanes: Part III Results

    NASA Technical Reports Server (NTRS)

    Sutliff, Daniel L.; Remington, Paul J.; Walker, Bruce E.

    2003-01-01

    A test program to demonstrate simplification of Active Noise Control (ANC) systems relative to standard techniques was performed on the NASA Glenn Active Noise Control Fan from May through September 2001. The target mode was the m = 2 circumferential mode generated by the rotor-stator interaction at 2BPF. Seven radials (combined inlet and exhaust) were present at this condition. Several different error-sensing strategies were implemented. Integration of the error-sensors with passive treatment was investigated. These were: (i) an in-duct linear axial array, (ii) an induct steering array, (iii) a pylon-mounted array, and (iv) a near-field boom array. The effect of incorporating passive treatment was investigated as well as reducing the actuator count. These simplified systems were compared to a fully ANC specified system. Modal data acquired using the Rotating Rake are presented for a range of corrected fan rpm. Simplified control has been demonstrated to be possible but requires a well-known and dominant mode signature. The documented results here in are part III of a three-part series of reports with the same base title. Part I and II document the control system and error-sensing design and implementation.

  10. 40 CFR 51.123 - Findings and requirements for submission of State implementation plan revisions relating to...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the source: (i) For EGUs and for fossil-fuel-fired non-EGUs that are boilers or combustion turbines... sources in the State. (ii) If a State elects to impose control measures on fossil fuel-fired non-EGUs that... part 75 of this chapter. (ii) If the SIP revision contains measures to control fossil fuel-fired non...

  11. 40 CFR 51.123 - Findings and requirements for submission of State implementation plan revisions relating to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the source: (i) For EGUs and for fossil-fuel-fired non-EGUs that are boilers or combustion turbines... sources in the State. (ii) If a State elects to impose control measures on fossil fuel-fired non-EGUs that... part 75 of this chapter. (ii) If the SIP revision contains measures to control fossil fuel-fired non...

  12. 40 CFR 51.123 - Findings and requirements for submission of State implementation plan revisions relating to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the source: (i) For EGUs and for fossil-fuel-fired non-EGUs that are boilers or combustion turbines... sources in the State. (ii) If a State elects to impose control measures on fossil fuel-fired non-EGUs that... part 75 of this chapter. (ii) If the SIP revision contains measures to control fossil fuel-fired non...

  13. 40 CFR 51.123 - Findings and requirements for submission of State implementation plan revisions relating to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the source: (i) For EGUs and for fossil-fuel-fired non-EGUs that are boilers or combustion turbines... sources in the State. (ii) If a State elects to impose control measures on fossil fuel-fired non-EGUs that... part 75 of this chapter. (ii) If the SIP revision contains measures to control fossil fuel-fired non...

  14. 40 CFR 51.123 - Findings and requirements for submission of State implementation plan revisions relating to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the source: (i) For EGUs and for fossil-fuel-fired non-EGUs that are boilers or combustion turbines... sources in the State. (ii) If a State elects to impose control measures on fossil fuel-fired non-EGUs that... part 75 of this chapter. (ii) If the SIP revision contains measures to control fossil fuel-fired non...

  15. Medical Devices; General Hospital and Personal Use Devices; Classification of the Image Processing Device for Estimation of External Blood Loss. Final order.

    PubMed

    2017-12-20

    The Food and Drug Administration (FDA or we) is classifying the image processing device for estimation of external blood loss into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the image processing device for estimation of external blood loss' classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  16. 77 FR 58707 - Minimum Internal Control Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... Gaming Commission 25 CFR Part 543 Minimum Internal Control Standards; Final Rule #0;#0;Federal Register... Control Standards AGENCY: National Indian Gaming Commission, Interior. ACTION: Final rule. SUMMARY: The National Indian Gaming Commission (NIGC) amends its minimum internal control standards for Class II gaming...

  17. Market-Based Coordination of Thermostatically Controlled Loads—Part II: Unknown Parameters and Case Studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Sen; Zhang, Wei; Lian, Jianming

    This two-part paper considers the coordination of a population of Thermostatically Controlled Loads (TCLs) with unknown parameters to achieve group objectives. The problem involves designing the bidding and market clearing strategy to motivate self-interested users to realize efficient energy allocation subject to a peak power constraint. The companion paper (Part I) formulates the problem and proposes a load coordination framework using the mechanism design approach. To address the unknown parameters, Part II of this paper presents a joint state and parameter estimation framework based on the expectation maximization algorithm. The overall framework is then validated using real-world weather data andmore » price data, and is compared with other approaches in terms of aggregated power response. Simulation results indicate that our coordination framework can effectively improve the efficiency of the power grid operations and reduce power congestion at key times.« less

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    Discussion Session - Accelerator System Design (Part II) Tutors: C. Darve, J. Weisend II, Ph. Lebrun, A. Dabrowski, U. Raich Video Conference with the CERN Control Center. Experts in the field of Accelerator science will be available to answer the students questions. This session will link the CCC and SA (using Codec VC).

  19. Medical Devices; Gastroenterology-Urology Devices; Classification of the Metallic Biliary Stent System for Benign Strictures. Final order.

    PubMed

    2016-07-13

    The Food and Drug Administration (FDA) is classifying the metallic biliary stent system for benign strictures into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the metallic biliary stent system for benign strictures' classification. The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device.

  20. 25 CFR 543.1 - What does this part cover?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What does this part cover? 543.1 Section 543.1 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS FOR CLASS II GAMING § 543.1 What does this part cover? This part, along with §§ 542.14 through 542...

  1. Effects of designed learning strategies to enhance biology students' understanding of the nature of science

    NASA Astrophysics Data System (ADS)

    Reeves, Carolyn T.

    This research attempted to test the effectiveness of strategies designed for teaching the nature of science to Biology I students and to examine the effects of frequency of use of the strategies. Some strategies were designed to identify misconceptions about the nature of science; others were designed to correct misconceptions or provide correct concepts about the nature of science. This research commenced during the 3rd week of the 2001--2002 school year after obtaining IRB approval and permissions from school officials. The study ended after the 15th week. All participating students were given a pretest and a posttest of the Nature of Scientific Knowledge Scale Enhanced (NSKSE) test. Part I, 48 items, consisted of the NSKS test by Rubba & Anderson (1978). Part II, 10 items, consisted of a test constructed by the researcher. Part I contained questions about 6 tenets of the nature of science. Part II contained questions about how science works. The strategies were tested in two Biology I experimental classes, n = 41, and compared with two Biology I control classes, n = 34, by means of an analysis of covariance with the pretest scores used as the covariate. The overall mean posttest scores of the experimental and the control group were not found to be significantly different on either Part I, F(1,72) = 1.059, p = .307, or Part II, F(1,72) = 3.136, p = .081, of the test instrument. The number of times a strategy was used in each experimental classroom was determined. It was found that strategies were used almost twice as often in one classroom than in the other. A second set of ANCOVA analyses compared mean scores between Experimental Class A, Experimental Class B, and the control group. There was no significant difference between the groups on Part I, F(2,71) = .921, p = .403, but the difference between groups on Part II, F(2,71) = 5.769, p = .005, was significant. A post hoc Scheffe analysis showed that the class using strategies most often differed significantly with the control group, p = .009, but the other class did not, p = .929. This study suggests that frequent use of the designed strategies was effective in helping Biology I students understand some aspects of the nature of science. It also suggests that minimal use of the strategies was not effective.

  2. Constrained model predictive control, state estimation and coordination

    NASA Astrophysics Data System (ADS)

    Yan, Jun

    In this dissertation, we study the interaction between the control performance and the quality of the state estimation in a constrained Model Predictive Control (MPC) framework for systems with stochastic disturbances. This consists of three parts: (i) the development of a constrained MPC formulation that adapts to the quality of the state estimation via constraints; (ii) the application of such a control law in a multi-vehicle formation coordinated control problem in which each vehicle operates subject to a no-collision constraint posed by others' imperfect prediction computed from finite bit-rate, communicated data; (iii) the design of the predictors and the communication resource assignment problem that satisfy the performance requirement from Part (ii). Model Predictive Control (MPC) is of interest because it is one of the few control design methods which preserves standard design variables and yet handles constraints. MPC is normally posed as a full-state feedback control and is implemented in a certainty-equivalence fashion with best estimates of the states being used in place of the exact state. However, if the state constraints were handled in the same certainty-equivalence fashion, the resulting control law could drive the real state to violate the constraints frequently. Part (i) focuses on exploring the inclusion of state estimates into the constraints. It does this by applying constrained MPC to a system with stochastic disturbances. The stochastic nature of the problem requires re-posing the constraints in a probabilistic form. In Part (ii), we consider applying constrained MPC as a local control law in a coordinated control problem of a group of distributed autonomous systems. Interactions between the systems are captured via constraints. First, we inspect the application of constrained MPC to a completely deterministic case. Formation stability theorems are derived for the subsystems and conditions on the local constraint set are derived in order to guarantee local stability or convergence to a target state. If these conditions are met for all subsystems, then this stability is inherited by the overall system. For the case when each subsystem suffers from disturbances in the dynamics, own self-measurement noises, and quantization errors on neighbors' information due to the finite-bit-rate channels, the constrained MPC strategy developed in Part (i) is appropriate to apply. In Part (iii), we discuss the local predictor design and bandwidth assignment problem in a coordinated vehicle formation context. The MPC controller used in Part (ii) relates the formation control performance and the information quality in the way that large standoff implies conservative performance. We first develop an LMI (Linear Matrix Inequality) formulation for cross-estimator design in a simple two-vehicle scenario with non-standard information: one vehicle does not have access to the other's exact control value applied at each sampling time, but to its known, pre-computed, coupling linear feedback control law. Then a similar LMI problem is formulated for the bandwidth assignment problem that minimizes the total number of bits by adjusting the prediction gain matrices and the number of bits assigned to each variable. (Abstract shortened by UMI.)

  3. 40 CFR 61.10 - Source reporting and waiver request.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... control equipment for each emission point including— (i) Each control device for each hazardous pollutant; and (ii) Estimated control efficiency (percent) for each control device. (7) A statement by the owner... 60 or part 63 standard, whichever is latest. Procedures governing the implementation of this...

  4. Medical Devices; Immunology and Microbiology Devices; Classification of the Device To Detect and Identify Microbial Pathogen Nucleic Acids in Cerebrospinal Fluid. Final order.

    PubMed

    2017-10-20

    The Food and Drug Administration (FDA or we) is classifying the device to detect and identify microbial pathogen nucleic acids in cerebrospinal fluid into class II (special controls). The special controls that will apply to the device type are identified in this order and will be part of the codified language for the device to detect and identify microbial pathogen nucleic acids in cerebrospinal fluid’s classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  5. The new production theory for health care through clinical reengineering: a study of clinical guidelines--Part II.

    PubMed

    Sharp, J R

    1995-01-01

    In Part I of this two-part article, in the December 1994 issue of the journal, the author discussed the manufacturing theories of Peter Drucker in terms of their applicability for the health care field. He concluded that Drucker's four principles and practices of manufacturing--statistical quality control, manufacturing accounting, modular organization, and systems approach--do have application to the health care system. Clinical guidelines, a variation on the Drucker theory, are a specific example of the manufacturing process in health. The performance to date of some guidelines and their implications for the health care reform debate are discussed in Part II of the article.

  6. Student System, On-Line Admissions.

    ERIC Educational Resources Information Center

    White, Stephen R.

    This report provides technical information on an on-line admissions system developed by Montgomery College. Part I, Systems Development, describes the background, objectives and responsibilities, system design, and reports generated by the system. Part II, Operating Instructions, describes input forms and controls, admission system functions, file…

  7. Tobacco control and gender in south-east Asia. Part II: Singapore and Vietnam.

    PubMed

    Morrow, Martha; Barraclough, Simon

    2003-12-01

    In the World Health Organization's Western Pacific Region, being born male is the single greatest risk marker for tobacco use. While the literature demonstrates that risks associated with tobacco use may vary according to sex, gender refers to the socially determined roles and responsibilities of men and women, who initiate, continue and quit using tobacco for complex and often different reasons. Cigarette advertising frequently appeals to gender roles. Yet tobacco control policy tends to be gender-blind. Using a broad, gender-sensitivity framework, this contradiction is explored in four Western Pacific countries. Part I of the study presented the rationale, methodology and design of the study, discussed issues surrounding gender and tobacco, and analysed developments in Malaysia and the Philippines (see the previous issue of this journal). Part II deals with Singapore and Vietnam. In all four countries gender was salient for the initiation and maintenance of smoking. Yet, with a few exceptions, gender was largely unrecognized in control policy. Suggestions for overcoming this weakness in order to enhance tobacco control are made.

  8. On-Line Remote Catalog Access and Circulation Control System. Part I: Functional Specifications. Part II: User's Manual.

    ERIC Educational Resources Information Center

    International Business Machines Corp., Gaithersburg, MD. Data Processing Div.

    The Ohio State University Libraries On-line Remote Catalog Access and Circulation Control System (LCS) began on-line operations with the conversion of one department library in November 1970. By December all 26 libraries had been converted to the automated system and LCS was fully operational one month ahead of schedule. LCS is designed as a…

  9. Medical Devices; General Hospital and Personal Use Devices; Classification of the Ultraviolet Radiation Chamber Disinfection Device. Final order.

    PubMed

    2015-11-20

    The Food and Drug Administration (FDA or the Agency) is classifying the ultraviolet (UV) radiation chamber disinfection device into class II (special controls). The special controls that will apply to the device are identified in this order and will be part of the codified language for the UV radiation chamber disinfection device classification. The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device.

  10. 40 CFR 52.720 - Identification of plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Illinois Pollution Control Board Regulations, Chapter 2, Parts I, II and III were submitted May 4, 1972, by the Governor. (3) A document describing the role of the Chicago Department of Environmental Control...) Compliance schedules submitted on March 13, 1973, by the Pollution Control Board. (6) Compliance schedules...

  11. Controller Evaluation of Initial Data Link Air Traffic Control Services: Mini Study 2 Volume II

    DOT National Transportation Integrated Search

    1989-03-01

    This report details the results of Mini Study 2. This Mini Study was conducted at the Federal Aviation Administration (FAA) Technical Center utilizing the Data Link test bed. Initial Data Link air traffic control services were evaluated under part ta...

  12. 40 CFR 52.720 - Identification of plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Illinois Pollution Control Board Regulations, Chapter 2, Parts I, II and III were submitted May 4, 1972, by the Governor. (3) A document describing the role of the Chicago Department of Environmental Control...) Compliance schedules submitted on March 13, 1973, by the Pollution Control Board. (6) Compliance schedules...

  13. Dimensional and material characteristics of direct deposited tool steel by CO II laser

    NASA Astrophysics Data System (ADS)

    Choi, J.

    2006-01-01

    Laser aided direct metalimaterial deposition (DMD) process builds metallic parts layer-by-layer directly from the CAD representation. In general, the process uses powdered metaUmaterials fed into a melt pool, creating fully dense parts. Success of this technology in the die and tool industry depends on the parts quality to be achieved. To obtain designed geometric dimensions and material properties, delicate control of the parameters such as laser power, spot diameter, traverse speed and powder mass flow rate is critical. In this paper, the dimensional and material characteristics of directed deposited H13 tool steel by CO II laser are investigated for the DMD process with a feedback height control system. The relationships between DMD process variables and the product characteristics are analyzed using statistical techniques. The performance of the DMD process is examined with the material characteristics of hardness, porosity, microstructure, and composition.

  14. Reliability of Fault Tolerant Control Systems. Part 1

    NASA Technical Reports Server (NTRS)

    Wu, N. Eva

    2001-01-01

    This paper reports Part I of a two part effort, that is intended to delineate the relationship between reliability and fault tolerant control in a quantitative manner. Reliability analysis of fault-tolerant control systems is performed using Markov models. Reliability properties, peculiar to fault-tolerant control systems are emphasized. As a consequence, coverage of failures through redundancy management can be severely limited. It is shown that in the early life of a syi1ein composed of highly reliable subsystems, the reliability of the overall system is affine with respect to coverage, and inadequate coverage induces dominant single point failures. The utility of some existing software tools for assessing the reliability of fault tolerant control systems is also discussed. Coverage modeling is attempted in Part II in a way that captures its dependence on the control performance and on the diagnostic resolution.

  15. Quality control analysis : part II : soil and aggregate base course.

    DOT National Transportation Integrated Search

    1966-07-01

    This is the second of the three reports on the quality control analysis of highway construction materials. : It deals with the statistical evaluation of results from several construction projects to determine the basic pattern of variability with res...

  16. Erosion control study : final report : Part II : roadside channels.

    DOT National Transportation Integrated Search

    1971-04-01

    The objective of the study were: : 1) To evaluate present methods and develop new methods for establishing a permanent vegetative cover. : 2) To develop erosion control practices for existing highway drains and ditches. : 3) To develop highway bank s...

  17. 40 CFR 94.1104 - General enforcement provisions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES General Enforcement Provisions and... manufacturer of new engines and other persons subject to the requirements of this part must establish and... requirements of subpart E of this part. (ii) Every manufacturer or owner of engines exempted from the standards...

  18. 40 CFR 94.1104 - General enforcement provisions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES General Enforcement Provisions and... manufacturer of new engines and other persons subject to the requirements of this part must establish and... requirements of subpart E of this part. (ii) Every manufacturer or owner of engines exempted from the standards...

  19. 40 CFR 94.1104 - General enforcement provisions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES General Enforcement Provisions and... manufacturer of new engines and other persons subject to the requirements of this part must establish and... requirements of subpart E of this part. (ii) Every manufacturer or owner of engines exempted from the standards...

  20. 40 CFR 94.1104 - General enforcement provisions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES General Enforcement Provisions and... manufacturer of new engines and other persons subject to the requirements of this part must establish and... requirements of subpart E of this part. (ii) Every manufacturer or owner of engines exempted from the standards...

  1. 40 CFR 94.1104 - General enforcement provisions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES General Enforcement Provisions and... manufacturer of new engines and other persons subject to the requirements of this part must establish and... requirements of subpart E of this part. (ii) Every manufacturer or owner of engines exempted from the standards...

  2. Theory for controlling individual self-propelled micro-swimmers by photon nudging II: confinement.

    PubMed

    Selmke, Markus; Khadka, Utsab; Bregulla, Andreas P; Cichos, Frank; Yang, Haw

    2018-04-18

    Photon nudging allows the manipulation and confinement of individual self-propelled micro-swimmers in 2D and 3D environments using feedback controls. Presented in this second part of a two-part contribution are theoretical models that afford the characterization for the positioning distribution associated with active localization. A derivation for the optimal nudging speed and acceptance angle is given for minimal placement uncertainty. The analytical solutions allow for a discussion on the physical underpinning that underlies controllability and optimality.

  3. A randomized, clinical trial to assess the relative efficacy and tolerability of two doses of etoricoxib versus naproxen in patients with ankylosing spondylitis.

    PubMed

    Balazcs, Eva; Sieper, Joachim; Bickham, Kara; Mehta, Anish; Frontera, Nancy; Stryszak, Paul; Popmihajlov, Zoran; Peloso, Paul M

    2016-10-13

    This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS). This was a 2-part, double-blind, active comparator-controlled non-inferiority study in subjects ≥18 years of age with AS. In Part I, subjects were randomized to naproxen 1000 mg; etoricoxib 60 mg, and 90 mg. In Part II, naproxen and etoricoxib 90 mg subjects continued on the same treatment; subjects on etoricoxib 60 mg either continued on 60 mg or escalated to 90 mg. Part I (6 weeks) assessed the efficacy of A) etoricoxib 60 mg vs. naproxen and B) 90 mg vs. naproxen according to the time-weighted average change from baseline in Spinal Pain Intensity (SPI; 0-100 mm VAS) (primary endpoint). The non-inferiority margin was set at 8 mm for SPI. In Part II (20 weeks) we evaluated the potential benefit of increasing from 60 to 90 mg (predefined minimum clinically important difference = 6 mm in SPI) for inadequate responders (<50 % improvement from baseline in SPI) on etoricoxib 60 mg in Part I. In total, 1015 subjects were randomized to receive etoricoxib 60 mg (N = 702), etoricoxib 90 mg (N = 156), and naproxen 1000 mg (N = 157); 70.9 % were male and the mean age was 45.2 years. There were 919 subjects who completed Part I and all continued to Part II. In Part I, SPI change was non-inferior for both etoricoxib doses vs. naproxen. In both Part I and II, the incidence of adverse events (AEs), drug-related AEs, and serious adverse events (SAEs) were similar between the 3 treatment groups. Both doses of etoricoxib were non-inferior to naproxen. All treatments were well tolerated. Etoricoxib 60 and 90 mg effectively control pain in patients with AS, with 60 mg once daily as the lowest effective dose for most patients. Clinical Trials Registry # NCT01208207 . Registered on 22 September 2010.

  4. Medical devices; radiology devices; reclassification of full-field digital mammography system. Final rule.

    PubMed

    2010-11-05

    The Food and Drug Administration (FDA) is announcing the reclassification of the full-field digital mammography (FFDM) system from class III (premarket approval) to class II (special controls). The device type is intended to produce planar digital x-ray images of the entire breast; this generic type of device may include digital mammography acquisition software, full-field digital image receptor, acquisition workstation, automatic exposure control, image processing and reconstruction programs, patient and equipment supports, component parts, and accessories. The special control that will apply to the device is the guidance document entitled "Class II Special Controls Guidance Document: Full-Field Digital Mammography System." FDA is reclassifying the device into class II (special controls) because general controls along with special controls will provide a reasonable assurance of safety and effectiveness of the device. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of the guidance document that will serve as the special control for this device.

  5. 75 FR 82317 - Risk-Based Capital Standards: Advanced Capital Adequacy Framework-Basel II; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... collection unless it displays a currently valid Office of Management and Budget (OMB) control number. Each of... CORPORATION 12 CFR Part 325 RIN 3064-AD58 Risk-Based Capital Standards: Advanced Capital Adequacy Framework--Basel II; Establishment of a Risk-Based Capital Floor AGENCY: Office of the Comptroller of the Currency...

  6. Hydrocarbons and Air Pollution: An Annotated Bibliography. Part I., Categories A to E and Part II., Categories F to M and Indexes.

    ERIC Educational Resources Information Center

    National Air Pollution Control Administration (DHEW), Raleigh, NC.

    This two-part bibliography represents an effort to collect, condense, and organize the literature on the hydrocarbons in relation to air pollution. The approximately 2,300 documents abstracted are all included in the information storage and retrieval system of the National Air Pollution Control Administration's (NAPCA) Air Pollution Technical…

  7. Medical Devices; Immunology and Microbiology Devices; Classification of the Device To Detect and Measure Non-Microbial Analyte(s) in Human Clinical Specimens To Aid in Assessment of Patients With Suspected Sepsis. Final order.

    PubMed

    2017-10-24

    The Food and Drug Administration (FDA or we) is classifying the device to detect and measure non-microbial analyte(s) in human clinical specimens to aid in assessment of patients with suspected sepsis into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the device to detect and measure non-microbial analyte(s) in human clinical specimens to aid in assessment of patients with suspected sepsis's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device. We believe this action will also enhance patients' access to beneficial innovative devices, in part by reducing regulatory burdens.

  8. Working draft of the FDA GMP final rule (Part II).

    PubMed

    Donawa, M E

    1995-11-01

    Part I of this two-part series provided information on the proposed design control provisions of the US Food and Drug Administration's (FDA) working draft of the final rule for new good manufacturing practice regulations for medical devices. The final rule could be published in April or May 1996. It would be in force 180 days after the date of publication. Design control requirements may become effective some months later. This article describes recommended modifications of three provisions that have been intensely discussed during recent FDA-sponsored public meetings.

  9. 76 FR 53817 - Minimum Internal Control Standards for Class II Gaming

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Accounting, Gambling, Indians--lands, Reporting and recordkeeping requirements. 25 CFR Part 543 Administrative practice and procedure, Gambling, Indians--lands, Reporting and recordkeeping requirements. For...

  10. Stability and control of flexible satellites. II - Control

    NASA Technical Reports Server (NTRS)

    Huang, T. C.; Das, A.

    1980-01-01

    It is demonstrated that by monitoring the deformations of the flexible elements of a satellite, the effectiveness of the satellite control system can be increased considerably. A simple model of a flexible satellite was analyzed in the first part of this work. The same model is used here for digital computer simulations.

  11. 7 CFR 1469.5 - Eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CFR Part 12; (2) Have control of the land for the life of the proposed contract period. (i) The Chief... instances in which the Chief determines that there is sufficient assurance of control; and (ii) If the applicant is a tenant, the applicant must provide NRCS with the written evidence or assurance of control...

  12. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of Pollution Control and Ecology, P.O. Box 9583, Little Rock, Arkansas 72219, 501/562-7444 California (State Form), Executive Director, State Water Resources Control Board, P.O. Box 100, Sacramento... and Waste Management, Department of Natural Resources and Environmental Control, P.O. Box 1401, 89...

  13. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of Pollution Control and Ecology, P.O. Box 9583, Little Rock, Arkansas 72219, 501/562-7444 California (State Form), Executive Director, State Water Resources Control Board, P.O. Box 100, Sacramento... and Waste Management, Department of Natural Resources and Environmental Control, P.O. Box 1401, 89...

  14. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of Pollution Control and Ecology, P.O. Box 9583, Little Rock, Arkansas 72219, 501/562-7444 California (State Form), Executive Director, State Water Resources Control Board, P.O. Box 100, Sacramento... and Waste Management, Department of Natural Resources and Environmental Control, P.O. Box 1401, 89...

  15. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of Pollution Control and Ecology, P.O. Box 9583, Little Rock, Arkansas 72219, 501/562-7444 California (State Form), Executive Director, State Water Resources Control Board, P.O. Box 100, Sacramento... and Waste Management, Department of Natural Resources and Environmental Control, P.O. Box 1401, 89...

  16. 40 CFR Appendix II to Part 280 - List of Agencies Designated To Receive Notifications

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of Pollution Control and Ecology, P.O. Box 9583, Little Rock, Arkansas 72219, 501/562-7444 California (State Form), Executive Director, State Water Resources Control Board, P.O. Box 100, Sacramento... and Waste Management, Department of Natural Resources and Environmental Control, P.O. Box 1401, 89...

  17. 40 CFR 63.99 - Delegated Federal authorities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... been delegated to the air pollution control agencies in each State under the procedures described in... 26 Pulp & Paper II (Combustion sources) MM X X X 27 Generic MACT: Control Devices SS X X X Eq. Leaks... of 40 CFR Part 63 General Provisions Authorities to State and Local Air Pollution Control Agencies...

  18. 14 CFR 417.111 - Launch plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... controls identified by a launch operator's ground safety analysis and implementation of the ground safety.... (ii) For each toxic propellant, any hazard controls and process constraints determined under the... classification and compatibility group as defined by part 420 of this chapter. (3) A graphic depiction of the...

  19. Poppy Eradication in Afghanistan: Why Isn’t It Working?

    DTIC Science & Technology

    2009-03-17

    convulsions, fever • Complications from intravenous use: infections from contaminated needles, hepatitis, TB, tetanus, pneumonia, bacterial... endocarditis NOTE: The Controlled Substances Act is part ofTitle II of the Comprehensive Drug Abuse Prevention and Control Act of 1970. The purpose is to

  20. 15 CFR Supplement No. 4 to Part 774 - Commerce Control List Order of Review

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...” paragraph such as a “.x” paragraph that controls unspecified “parts” and “components” “specially designed... ECCN paragraph that contains a “specially designed” control parameter. Skip to Step 5. (ii) Step 4.b... within the scope of the ECCN paragraph that contains a “specially designed” control parameter. Note to...

  1. Wind tunnel tests of the dynamic characteristics of the fluidic rudder

    NASA Technical Reports Server (NTRS)

    Belsterling, C. A.

    1976-01-01

    The fourth phase is given of a continuing program to develop the means to stabilize and control aircraft without moving parts or a separate source of power. Previous phases have demonstrated the feasibility of (1) generating adequate control forces on a standard airfoil, (2) controlling those forces with a fluidic amplifier and (3) cascading non-vented fluidic amplifiers operating on ram air supply pressure. The foremost objectives of the fourth phase covered under Part I of this report were to demonstrate a complete force-control system in a wind tunnel environment and to measure its static and dynamic control characteristics. Secondary objectives, covered under Part II, were to evaluate alternate configurations for lift control. The results demonstrate an overall response time of 150 msec, confirming this technology as a viable means for implementing low-cost reliable flight control systems.

  2. 42 CFR 414.412 - Submission of bids under a competitive bidding program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... D of this part. (c) Furnishing of items. A bid must include all costs related to furnishing an item... capital, stock or profits of another supplier; (ii) A controlling interest exists if one or more of owners... controlling interest and each supplier which has an ownership or controlling interest in it. (3) Commonly...

  3. Reexamination of color vision standards, part II. a computational method to assess the effect of color deficiencies in using ATC displays : final report.

    DOT National Transportation Integrated Search

    2006-03-01

    The previous study showed that many colors were used in air traffic control displays. We also found that colors were used mainly for three purposes: capturing controllers immediate attention, identifying targets, and segmenting information. This r...

  4. 21 CFR 884.6110 - Assisted reproduction catheters.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... procedures to introduce or remove gametes, zygote(s), preembryo(s), and/or embryo(s) into or from the body..., and component parts. (b) Classification. Class II (special controls) (mouse embryo assay information...

  5. 21 CFR 884.6110 - Assisted reproduction catheters.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... procedures to introduce or remove gametes, zygote(s), preembryo(s), and/or embryo(s) into or from the body..., and component parts. (b) Classification. Class II (special controls) (mouse embryo assay information...

  6. 21 CFR 884.6110 - Assisted reproduction catheters.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... procedures to introduce or remove gametes, zygote(s), preembryo(s), and/or embryo(s) into or from the body..., and component parts. (b) Classification. Class II (special controls) (mouse embryo assay information...

  7. 21 CFR 884.6110 - Assisted reproduction catheters.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... procedures to introduce or remove gametes, zygote(s), preembryo(s), and/or embryo(s) into or from the body..., and component parts. (b) Classification. Class II (special controls) (mouse embryo assay information...

  8. 21 CFR 884.6110 - Assisted reproduction catheters.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... procedures to introduce or remove gametes, zygote(s), preembryo(s), and/or embryo(s) into or from the body..., and component parts. (b) Classification. Class II (special controls) (mouse embryo assay information...

  9. Biological Control of Aquatic Plants with Pathogenic Fungi

    DTIC Science & Technology

    1981-01-01

    reverse side II necoosary and Ident•l•y by block number) Aquatic plant control Fungi Aquatic plants Pathogenic fungi Biological control Waterhyacinths...BACTERIA ............. ................. D1 2 1 BIOTIGICAL CONTROL OF AQUATIC PLANTS WITH PATHOGENIC FUNGI PART I: INTRODUCTION 1. Plant pathogens have...first noted in Florida. 13. In December of 1973, Dr. K. E. Ctnway isolated a Cercospora species, along with many other fungi , from declining

  10. Implementing AORN recommended practices for a safe environment of care, part II.

    PubMed

    Kennedy, Lynne

    2014-09-01

    Construction in and around a working perioperative suite is a challenge beyond merely managing traffic patterns and maintaining the sterile field. The AORN "Recommended practices for a safe environment of care, part II" provides guidance on building design; movement of patients, personnel, supplies, and equipment; environmental controls; safety and security; and control of noise and distractions. Whether the OR suite evolves through construction, reconstruction, or remodeling, a multidisciplinary team of construction experts and health care professionals should create a functional plan and communicate at every stage of the project to maintain a safe environment and achieve a well-designed outcome. Emergency preparedness, a facility-wide security plan, and minimization of noise and distractions in the OR also help enhance the safety of the perioperative environment. Copyright © 2014 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  11. 78 FR 151 - Energy Conservation Program: Test Procedures for Residential Clothes Dryers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... controls shall be no more than 2 percent when testing with the DOE test load to be representative of... Vol. 78 Wednesday, No. 1 January 2, 2013 Part II Department of Energy 10 CFR Parts 429 and 430... Register / Vol. 78 , No. 1 / Wednesday, January 2, 2013 / Proposed Rules#0;#0; [[Page 152

  12. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Okita, T.W.

    Part 1 of this research focuses on patterns of gene expression of ADPG-pyrophosphorylase in native and transgenic potato plants. To elucidate the mechanism controlling AGP expression during plant development, the expression of the potato tuber AGP small subunit (sAGP) gene was analyzed in transgenic potato plants using a promoter-{beta}-glucuronidase expression system. Part II evaluated the structure-function relationships of AGP.

  13. Time frequency analysis of olfactory induced EEG-power change.

    PubMed

    Schriever, Valentin Alexander; Han, Pengfei; Weise, Stefanie; Hösel, Franziska; Pellegrino, Robert; Hummel, Thomas

    2017-01-01

    The objective of the present study was to investigate the usefulness of time-frequency analysis (TFA) of olfactory-induced EEG change with a low-cost, portable olfactometer in the clinical investigation of smell function. A total of 78 volunteers participated. The study was composed of three parts where olfactory stimuli were presented using a custom-built olfactometer. Part I was designed to optimize the stimulus as well as the recording conditions. In part II EEG-power changes after olfactory/trigeminal stimulation were compared between healthy participants and patients with olfactory impairment. In Part III the test-retest reliability of the method was evaluated in healthy subjects. Part I indicated that the most effective paradigm for stimulus presentation was cued stimulus, with an interstimulus interval of 18-20s at a stimulus duration of 1000ms with each stimulus quality presented 60 times in blocks of 20 stimuli each. In Part II we found that central processing of olfactory stimuli analyzed by TFA differed significantly between healthy controls and patients even when controlling for age. It was possible to reliably distinguish patients with olfactory impairment from healthy individuals at a high degree of accuracy (healthy controls vs anosmic patients: sensitivity 75%; specificity 89%). In addition we could show a good test-retest reliability of TFA of chemosensory induced EEG-power changes in Part III. Central processing of olfactory stimuli analyzed by TFA reliably distinguishes patients with olfactory impairment from healthy individuals at a high degree of accuracy. Importantly this can be achieved with a simple olfactometer.

  14. 21 CFR 886.3920 - Aqueous shunt.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  15. 21 CFR 886.3400 - Keratoprosthesis.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  16. 21 CFR 886.3920 - Aqueous shunt.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  17. 21 CFR 886.3400 - Keratoprosthesis.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  18. 21 CFR 886.3920 - Aqueous shunt.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  19. 21 CFR 886.3400 - Keratoprosthesis.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  20. 21 CFR 886.3920 - Aqueous shunt.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  1. 21 CFR 886.3920 - Aqueous shunt.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  2. 21 CFR 886.3400 - Keratoprosthesis.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  3. 21 CFR 886.3400 - Keratoprosthesis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Classification. Class II. The special controls for this device are FDA's: (1) “Use of International Standard ISO 10993 ‘Biological Evaluation of Medical Devices—Part I: Evaluation and Testing,’ ” (2) “510(k) Sterility...

  4. How to unlock the benefits of MRP (materiel requirements planning) II and Just-in-Time.

    PubMed

    Jacobi, M A

    1994-05-01

    Manufacturing companies need to use the best and most applicable parts of MRP II and JIT to run their businesses effectively. MRP II provides the methodology to plan and control the total resources of the company and focuses on the processes that add value to their customers' products. It is the cornerstone of total quality management, as it reduces the variability and costly activities in the communication and subsequent execution of the required steps from customer order to shipment. JIT focuses on simplifying the total business operation and execution of business processes. MRP II and JIT are the foundations for successful manufacturing businesses.

  5. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.

    PubMed

    Sverdlov, Aaron L; Elezaby, Aly; Behring, Jessica B; Bachschmid, Markus M; Luptak, Ivan; Tu, Vivian H; Siwik, Deborah A; Miller, Edward J; Liesa, Marc; Shirihai, Orian S; Pimentel, David R; Cohen, Richard A; Colucci, Wilson S

    2015-01-01

    Diet-induced obesity leads to metabolic heart disease (MHD) characterized by increased oxidative stress that may cause oxidative post-translational modifications (OPTM) of cardiac mitochondrial proteins. The functional consequences of OPTM of cardiac mitochondrial proteins in MHD are unknown. Our objective was to determine whether cardiac mitochondrial dysfunction in MHD due to diet-induced obesity is associated with cysteine OPTM. Male C57BL/6J mice were fed either a high-fat, high-sucrose (HFHS) or control diet for 8months. Cardiac mitochondria from HFHS-fed mice (vs. control diet) had an increased rate of H2O2 production, a decreased GSH/GSSG ratio, a decreased rate of complex II substrate-driven ATP synthesis and decreased complex II activity. Complex II substrate-driven ATP synthesis and complex II activity were partially restored ex-vivo by reducing conditions. A biotin switch assay showed that HFHS feeding increased cysteine OPTM in complex II subunits A (SDHA) and B (SDHB). Using iodo-TMT multiplex tags we found that HFHS feeding is associated with reversible oxidation of cysteines 89 and 231 in SDHA, and 100, 103 and 115 in SDHB. MHD due to consumption of a HFHS "Western" diet causes increased H2O2 production and oxidative stress in cardiac mitochondria associated with decreased ATP synthesis and decreased complex II activity. Impaired complex II activity and ATP production are associated with reversible cysteine OPTM of complex II. Possible sites of reversible cysteine OPTM in SDHA and SDHB were identified by iodo-TMT tag labeling. Mitochondrial ROS may contribute to the pathophysiology of MHD by impairing the function of complex II. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease". Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Air Pollution Control, Part II.

    ERIC Educational Resources Information Center

    Strauss, Werner, Ed.

    This book contains five major articles in areas of current importance in air pollution control. They are written by authors who are actively participating in the areas on which they report. It is the aim of each article to completely cover theory, experimentation, and practice in the field discussed. The contents are as follows: Emissions,…

  7. Hypertension in Children and Adolescents. Part II: Pharmacologic Control--What Works and Why.

    ERIC Educational Resources Information Center

    Daniels, Stephen R.; Loggie, Jennifer M. H.

    1992-01-01

    In discussing pharmacologic control of hypertension in children and adolescents who participate in sports, the second of two articles emphasizes drugs with few side effects and that usually do not alter heart rate (e.g., long-lasting angiotensin-converting enzyme inhibitors or calcium channel blockers). Such drugs allow continued sports…

  8. 40 CFR 725.975 - EPA approval of alternative control measures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) TOXIC SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS Additional... equivalency to EPA under this part must submit the request to EPA (via CDX) using e-PMN software. See 40 CFR 720.40(a)(2)(ii) for information on how to obtain e-PMN software. Support documents related to these...

  9. Clinical and functional outcome of assertive outreach for patients with schizophrenic disorder: Results of a quasi-experimental controlled trial.

    PubMed

    Kästner, D; Büchtemann, D; Warnke, I; Radisch, J; Baumgardt, J; Giersberg, S; Kopke, K; Moock, J; Kawohl, W; Rössler, W

    2015-09-01

    The majority of studies support modern assertive health service models. However, the evidence is limited for parts of continental Europe, as well as for the pharmacological adherence outcome parameter. We conducted a quasi-experimental controlled trial including adult patients with a schizophreniform disorder and a maximum of 60 points on the Global Assessment of Functioning Scale (GAF). Interventions (n=176) and controls (TAU, n=142) were assessed every six-month within one year in 17 study practices in rural areas. Mental and functional state were rated using the Brief Psychiatric Rating Scale (BPRS) and the GAF. Functional limitations and pharmacological adherence were patient-rated using the WHO-Disability Assessment Schedule II (WHODAS-II) and the Medication Adherence Report Scale (MARS). We computed multilevel mixed models. The GAF and BPRS of both groups improved significantly, yet the increase in the intervention group was significantly higher. In contrast, patient-rated variables - WHODAS-II and MARS - neither showed a stable temporal improvement nor a difference between groups. Our findings only partly support the investigated AO intervention, because of conflicting results between clinician- and patient-ratings. Accordingly, the benefits of AO need to be further evaluated. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  10. 76 FR 19907 - Clarification of Controlled Group Qualification Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... for part 1 continues to read in part as follows: Authority: 26 U.S.C. 7805 * * * 0 Par. 2. Section 1... paragraph (a)(1)(ii). 0 2. Adding Example 4 to paragraph (b)(4). 0 3. Adding a sentence at the end of...: For date of applicability, see Sec. 1.1563- 1(e). FOR FURTHER INFORMATION CONTACT: Grid Glyer (202...

  11. Medical devices; hematology and pathology devices; classification of early growth response 1 gene fluorescence in-situ hybridization test system for specimen characterization. Final order.

    PubMed

    2014-09-03

    The Food and Drug Administration (FDA) is classifying early growth response 1 (EGR1) gene fluorescence in-situ hybridization (FISH) test system for specimen characterization into class II (special controls). The special controls that will apply to this device are identified in this order and will be part of the codified language for the early growth response 1 (EGR1) gene fluorescence in-site hybridization (FISH) test system for specimen characterization classification. The Agency is classifying the device into class II (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device.

  12. Compressed-air power tools in orthopaedic surgery: exhaust air is a potential source of contamination.

    PubMed

    Sagi, H C; DiPasquale, Thomas; Sanders, Roy; Herscovici, Dolfi

    2002-01-01

    To determine if the exhaust from surgical compressed-air power tools contains bacteria and if the exhaust leads to contamination of sterile surfaces. Bacteriologic study of orthopaedic power tools. Level I trauma center operative theater. None. Part I. Exhaust from two sterile compact air drills was sampled directly at the exhaust port. Part II. Exhaust from the drills was directed at sterile agar plates from varying distances. The agar plates represented sterile surfaces within the operative field. Part III. Control cultures. A battery-powered drill was operated over open agar plates in similar fashion as the compressed-air drills. Agar plates left open in the operative theater served as controls to rule out atmospheric contamination. Random cultures were taken from agar plates, gloves, drills, and hoses. Incidence of positive cultures. In Part I, all filters from both compressed-air drill exhausts were culture negative ( = 0.008). In Part II, the incidence of positive cultures for air drills number one and number two was 73% and 82%, respectively. The most commonly encountered organisms were, coagulase-negative Staphylococcus, and Micrococcus species. All control cultures from agar plates, battery-powered drill, gloves, and hoses were negative ( < 0.01). Exhaust from compressed-air power tools in orthopaedic surgery may contribute to the dissemination of bacteria onto the surgical field. We do not recommend the use of compressed-air power tools that do not have a contained exhaust.

  13. Effect of basic fibroblast growth factor and transforming growth factor β1 on the healing of reconstructed dura by carbon dioxide laser soldering in minipigs.

    PubMed

    Zhong, Hong-liang; Wang, Zhen-min; Yang, Zhi-jun; Zhao, Fu; Wang, Bo; Wang, Zhong-cheng; Liu, Pi-nan

    2012-02-01

    Carbon dioxide (CO2) laser soldering is an alternative technique for tissue bonding. Basic fibroblast growth factor (bFGF) and transforming growth factor β(1) (TGFβ(1)) are two key factors for wound healing. This study was performed to demonstrate the efficacy of CO2 laser soldering for dural reconstruction and the effect of bFGF and TGFβ(1) on healing. In Part I, 10 minipigs were randomized into two equal groups. Dural defects were reconstructed by conventional fibrin glue bonding (group I(a)) or CO2 laser soldering (group I(b)). The reconstructed dura was subjected to burst pressure (BP) measurement and immunohistochemical staining after 1 week. In Part II, 36 minipigs were randomized into three equal groups. Dural reconstruction was achieved by CO2 laser soldering. Exogenous bFGF (group II(b)) or TGFβ(1) (group II(c)) was administered while group II(a) served as a control group. The specimens were subjected to BP measurement after 1, 2, 3, and 4 weeks, respectively. In Part I, the dura specimens displayed positive staining of only bFGF in group I(a) and of both bFGF and TGFβ(1) in group I(b). Group I(b) showed higher BP than group I(a) ((98.00 ± 21.41) mmHg vs. (70.80 ± 15.09) mmHg, respectively; P < 0.05). In Part II, BP of group II(c) was significantly higher than that of group II(a) (P < 0.01). The BP of group II(a) trended toward stabilization after 3 weeks of growth, while that of groups II(b) and II(c) trended toward stabilization after 2 weeks of growth. CO2 laser soldering is a reliable technique for dural reconstruction. The superior healing of dural reconstruction by CO2 laser soldering may be related to higher expression of bFGF and TGFβ(1), and CO2 lasers may stimulate their secretion. Exogenous bFGF or TGFβ(1) may improve healing by shortening the wound healing time, and exogenous TGFβ(1) may improve the tensile strength.

  14. Low Friction Hull Coatings for Icebreakers. Phase II, Parts I and II. Laboratory and Field Tests

    DTIC Science & Technology

    1976-02-01

    is a hybrid of the above systems . It contains no solvent, can cure at room temperature, is flexible and exhibits good wear characteristics. This...31 Figure I-12 Schematic of Humidity Control System Figure I-13 Effect of Velocity on the Friction Coefficient of...Application of a Conventional Epoxy System and a Vinyl Antifoul Photographs of the USCG Cutter Mackinaw during and after Application of Polyurethane Coating

  15. Reliability of Fault Tolerant Control Systems. Part 2

    NASA Technical Reports Server (NTRS)

    Wu, N. Eva

    2000-01-01

    This paper reports Part II of a two part effort that is intended to delineate the relationship between reliability and fault tolerant control in a quantitative manner. Reliability properties peculiar to fault-tolerant control systems are emphasized, such as the presence of analytic redundancy in high proportion, the dependence of failures on control performance, and high risks associated with decisions in redundancy management due to multiple sources of uncertainties and sometimes large processing requirements. As a consequence, coverage of failures through redundancy management can be severely limited. The paper proposes to formulate the fault tolerant control problem as an optimization problem that maximizes coverage of failures through redundancy management. Coverage modeling is attempted in a way that captures its dependence on the control performance and on the diagnostic resolution. Under the proposed redundancy management policy, it is shown that an enhanced overall system reliability can be achieved with a control law of a superior robustness, with an estimator of a higher resolution, and with a control performance requirement of a lesser stringency.

  16. Stimulus control: Part II

    PubMed Central

    Dinsmoor, James A.

    1995-01-01

    The second part of my tutorial stresses the systematic importance of two parameters of discrimination training: (a) the magnitude of the physical difference between the positive and the negative stimulus (disparity) and (b) the magnitude of the difference between the positive stimulus, in particular, and the background stimulation (salience). It then examines the role these variables play in such complex phenomena as blocking and overshadowing, progressive discrimination training, and the transfer of control by fading. It concludes by considering concept formation and imitation, which are important forms of application, and recent work on equivalence relations. PMID:22478222

  17. Electrical Experiments. VT-214-12-2. Part II. A-C Across the Line Control.

    ERIC Educational Resources Information Center

    Connecticut State Dept. of Education, Hartford. Div. of Vocational Education.

    Designed for high school electronics students, this second document in a series of six electrical learning activity packages focuses on alternating current across-the-line control. An introductory section gives the objective for the activities, an introduction, and an outline of the content. The remainder of the activity book is comprised of…

  18. AUTOMOTIVE DIESEL MAINTENANCE 2 UNIT IV, AUTOMATIC TRANSMISSIONS--HYDRAULICS (PART II).

    ERIC Educational Resources Information Center

    Human Engineering Inst., Cleveland, OH.

    THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF VALVES UTILIZED IN HYDRAULIC TRANSMISSIONS USED ON DIESEL POWERED VEHICLES. TOPICS ARE (1) REVIEWING FACTS ABOUT PUMPS, (2) USING VALVES FOR CONTROL, (3) TROUBLESHOOTING PROCEDURES ON RELIEF VALVES, (4) USING DIRECTIONAL CONTROL VALVES,…

  19. A Multidisciplinary PBL Robot Control Project in Automation and Electronic Engineering

    ERIC Educational Resources Information Center

    Hassan, Houcine; Domínguez, Carlos; Martínez, Juan-Miguel; Perles, Angel; Capella, Juan-Vicente; Albaladejo, José

    2015-01-01

    This paper presents a multidisciplinary problem-based learning (PBL) project consisting of the development of a robot arm prototype and the implementation of its control system. The project is carried out as part of Industrial Informatics (II), a compulsory third-year course in the Automation and Electronic Engineering (AEE) degree program at the…

  20. Passenger vehicle idling in Vermont, Phase II.

    DOT National Transportation Integrated Search

    2014-08-01

    While trip-start and trip-end idling, including idling at intermediary stops along a route, cannot be completely eliminated, the duration of these discretionary idling events is largely controlled by the driver and can be considered part of travel or...

  1. Stability of the human respiratory control system. II. Analysis of a three-dimensional delay state-space model.

    PubMed

    Batzel, J J; Tran, H T

    2000-07-01

    A number of mathematical models of the human respiratory control system have been developed since 1940 to study a wide range of features of this complex system. Among them, periodic breathing (including Cheyne-Stokes respiration and apneustic breathing) is a collection of regular but involuntary breathing patterns that have important medical implications. The hypothesis that periodic breathing is the result of delay in the feedback signals to the respiratory control system has been studied since the work of Grodins et al. in the early 1950's [1]. The purpose of this paper is to study the stability characteristics of a feedback control system of five differential equations with delays in both the state and control variables presented by Khoo et al. [4] in 1991 for modeling human respiration. The paper is divided in two parts. Part I studies a simplified mathematical model of two nonlinear state equations modeling arterial partial pressures of O2 and CO2 and a peripheral controller. Analysis was done on this model to illuminate the effect of delay on the stability. It shows that delay dependent stability is affected by the controller gain, compartmental volumes and the manner in which changes in the ventilation rate is produced (i.e., by deeper breathing or faster breathing). In addition, numerical simulations were performed to validate analytical results. Part II extends the model in Part I to include both peripheral and central controllers. This, however, necessitates the introduction of a third state equation modeling CO2 levels in the brain. In addition to analytical studies on delay dependent stability, it shows that the decreased cardiac output (and hence increased delay) resulting from the congestive heart condition can induce instability at certain control gain levels. These analytical results were also confirmed by numerical simulations.

  2. 40 CFR 52.2465 - Original identification of plan section.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., 2FSD, and pre-dryer 3FSD from Part IV, Rule EX-4, Section 4.41(i) until December 15, 1981, submitted on...) Appendix K (7) Appendix N (8) Appendix P (9) Appendix R I., II.B., II.D., II.E., II.F., II.G., II.H., II.I...) Amendments to Part I, Subpart 1.01 (Certain Terms Defined) and to Part IV, Section 4.52 (former Section 4.705...

  3. SHEFEX II - Aerodynamic Re-Entry Controlled Sharp Edge Flight Experiment

    NASA Astrophysics Data System (ADS)

    Longo, J. M. A.; Turner, J.; Weihs, H.

    2009-01-01

    In this paper the basic goals and architecture of the SHEFEX II mission is presented. Also launched by a two staged sounding rocket system SHEFEX II is a consequent next step in technology test and demonstration. Considering all experience and collected flight data obtained during the SHEFEX I Mission, the test vehicle has been re-designed and extended by an active control system, which allows active aerodynamic control during the re-entry phase. Thus, ceramic based aerodynamic control elements like rudders, ailerons and flaps, mechanical actuators and an automatic electronic control unit has been implemented. Special focus is taken on improved GNC Elements. In addition, some other experiments including an actively cooled thermal protection element, advanced sensor equipment, high temperature antenna inserts etc. are part of the SHEFEX II experimental payload. A final 2 stage configuration has been selected considering Brazilian solid rocket boosters derived from the S 40 family. During the experiment phase a maximum entry velocity of Mach around 10 is expected for 50 seconds. Considering these flight conditions, the heat loads are not representative for a RLV re-entry, however, it allows to investigate the principal behaviour of such a facetted ceramic TPS, a sharp leading edge at the canards and fins and all associated gas flow effects and their structural response.

  4. Plastic deformation and instability in thin-walled tubes under combined loading : a general theory. Part II

    NASA Astrophysics Data System (ADS)

    Hill, Rodney

    1999-02-01

    This analysis concerns closed-ended tubes of circular section which are loaded by internal fluid pressure together with an external axial force. These may be applied in proportions that can be varied at will by servo-control during a single experiment. More generally it is envisaged that the servo-control can respond to changes in tube radius when these are monitored by a diametral extensometer. A main objective is to determine how the choice of control affects the regime of homogeneous deformation. Another is to consolidate an understanding of the transition to inhomogeneous deformation mediated by eigenmodes. The general approach is along similar lines to part I and takes the analysis appreciably farther in important respects. The constitutive basis is broadly classical, but yield functions spanning the whole of stress space are not called upon, primarily because of the extreme scarcity of good experimental data. There are counter-balancing benefits from this abstention : (i) the governing equations can be handled far more readily ; (ii) the structure of the mathematics as a whole is more transparent ; (iii) the final conclusions are valid for materials whose path-dependent behaviour is much more complex than can be accommodated by the simple theories reviewed in Part I.

  5. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

  6. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

  7. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

  8. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

  9. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Deadlines for Parties in Countervailing Administrative Reviews II Annex II to Part 351 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Pt. 351, Annex II Annex II to Part 351—Deadlines for Parties...

  10. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part 504—Fuel Price Computation (a) Introduction. This appendix provides the equations and parameters...

  11. 40 CFR Appendix II to Part 1048 - Large Spark-ignition (SI) Composite Transient Cycle

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Transient Cycle II Appendix II to Part 1048 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY.... 1048, App. II Appendix II to Part 1048—Large Spark-ignition (SI) Composite Transient Cycle The following table shows the transient duty-cycle for engines that are not constant-speed engines, as described...

  12. Morgantown People Mover Redundant Computing System Design Summary

    DOT National Transportation Integrated Search

    1980-09-01

    The purpose of this report is to describe the redundant computing system design used for the current 1980 Phase II Morgantown People Mover (MPM) system. The redundant computing system is that part of the control and communications system (C&CS) consi...

  13. The Use of Programmable Calculators in the Teaching of Economics, Part II

    ERIC Educational Resources Information Center

    Addis, G. H.

    1978-01-01

    Describes the use of programmable calculators to perform classroom controlled experiments on economic models. The complete program for exploring the dynamics of the Harrod-Domar equation is given. Some difficulties encountered and statistical uses are mentioned. (BC)

  14. 40 CFR Appendix II to Part 261 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false [Reserved] II Appendix II to Part 261 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) IDENTIFICATION AND LISTING OF HAZARDOUS WASTE Appendix II to Part 261 [Reserved] ...

  15. Cancer Chemotherapy: Past, Present, and Future—Part I

    PubMed Central

    Wright, Jane C.

    1984-01-01

    Cancer is of major concern today because of its high mortality. It is estimated that 66 million people in this country will eventually develop cancer; 1983 estimates were 855,000 new cases and 440,000 deaths from cancer. Because of limitations of surgery and radiation therapy in effecting a cure for cancer, chemotherapy has become increasingly important. The developments in the chemical control of cancer in man are encouraging. This two-part paper covers the historical milestones in the development of the chemical and hormonal control of cancer, present successes with the use of polychemotherapy, and the hopeful trends in research. Part II will be published in a future issue of this journal. PMID:6381742

  16. 40 CFR 60.5412 - What additional requirements must I meet for determining initial compliance with control devices...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... (c) For each carbon adsorption system used as a control device to meet the requirements of paragraph... weight or greater as determined in accordance with the requirements of § 60.5413. (ii) You must reduce... than 20 parts per million by volume on a dry basis corrected to 3 percent oxygen as determined in...

  17. 26 CFR 1.597-4 - Bridge Banks and Agency Control.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... consolidated group for a taxable year under § 1.1502-76(b)(5)(ii), as contained in 26 CFR part 1 edition revised April 1, 1994, if the Institution is under Agency Control at any time during the year. (3... that become nonmembers within the meaning of § 1.1502-32(d)(4); (iii) The taxable year of the...

  18. Adaptive Control of Non-Minimum Phase Modal Systems Using Residual Mode Filters2. Parts 1 and 2

    NASA Technical Reports Server (NTRS)

    Balas, Mark J.; Frost, Susan

    2011-01-01

    Many dynamic systems containing a large number of modes can benefit from adaptive control techniques, which are well suited to applications that have unknown parameters and poorly known operating conditions. In this paper, we focus on a direct adaptive control approach that has been extended to handle adaptive rejection of persistent disturbances. We extend this adaptive control theory to accommodate problematic modal subsystems of a plant that inhibit the adaptive controller by causing the open-loop plant to be non-minimum phase. We will modify the adaptive controller with a Residual Mode Filter (RMF) to compensate for problematic modal subsystems, thereby allowing the system to satisfy the requirements for the adaptive controller to have guaranteed convergence and bounded gains. This paper will be divided into two parts. Here in Part I we will review the basic adaptive control approach and introduce the primary ideas. In Part II, we will present the RMF methodology and complete the proofs of all our results. Also, we will apply the above theoretical results to a simple flexible structure example to illustrate the behavior with and without the residual mode filter.

  19. 40 CFR Appendix II to Part 600 - Sample Fuel Economy Calculations

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Sample Fuel Economy Calculations II Appendix II to Part 600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. II Appendix II to Part 600—Sample Fuel Economy Calculations (...

  20. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used to...

  1. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... (APXi). If an alternate fuel other than coal is proposed the source or the derivation of the index must...

  2. 10 CFR Appendix II to Part 504 - Fuel Price Computation

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Fuel Price Computation II Appendix II to Part 504 Energy DEPARTMENT OF ENERGY (CONTINUED) ALTERNATE FUELS EXISTING POWERPLANTS Pt. 504, App. II Appendix II to Part... effects of future real price increases for each fuel. The delivered price of an alternate fuel used to...

  3. EMISSIONS PROFILE CHARACTERIZATION OF LAKE MICHIGAN POLLUTANT SOURCES - PART II

    EPA Science Inventory

    The southern Lake Michigan area continues to experience poor air quality despite the implementation of many measures to control particulate matter, ozone and toxic pollutants. Fortunately, the ambient atmosphere holds clues to these sources and their contributions to urban pollut...

  4. A/C Interface: Expert Systems: Part II.

    ERIC Educational Resources Information Center

    Dessy, Raymond E., Ed.

    1984-01-01

    Discusses working implementations of artificial intelligence systems for chemical laboratory applications. They include expert systems for liquid chromatography, spectral analysis, instrument control of a totally computerized triple-quadrupole mass spectrometer, and the determination of the mineral constituents of a rock sample given the powder…

  5. A laboratory comparison of clockwise and counter-clockwise rapidly rotating shift schedules, part II : performance : final report.

    DOT National Transportation Integrated Search

    2002-07-01

    INTRODUCTION. Many Air Traffic Control Specialists (ATCSs) work a relatively unique counter-clockwise, rapidly rotating shift schedule. Although arguments against these kinds of schedules are prevalent in the literature, few studies have examined rot...

  6. Feedback Flow Control for a Pitching Turret (Part II) (POSTPRINT)

    DTIC Science & Technology

    2010-01-01

    FL, 2007. 2S. Gordeyev , T. E. Hayden, and E. J. Jumper , “Aero-Optical and Flow Measurements Over a Flat-Windowed Turret,” AIAA Journal, Vol. 45, No...public release; distribution unlimited. 13. SUPPLEMENTARY NOTES Conference presentation published in the Proceedings of the 48th AIAA Aerospace...Compressible effects are not present at this speed, but systems for controlling velocity fluctuations in incompressible flows will be effective in controlling

  7. Quantitative Biofractal Feedback Part II ’Devices, Scalability & Robust Control’

    DTIC Science & Technology

    2008-05-01

    in the modelling of proton exchange membrane fuel cells ( PEMFC ) may work as a powerful tool in the development and widespread testing of alternative...energy sources in the next decade [9], where biofractal controllers will be used to control these complex systems. The dynamic model of PEMFC , is...dynamic response of the PEMFC . In the Iftukhar model, the fuel cell is represented by an equivalent circuit, whose components are identified with

  8. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

  9. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

  10. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

  11. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false NRC and EPA Requirements for Preclosure Repository Performance II Appendix II to Part 960 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and...

  12. Cancer Chemotherapy: Past, Present, and Future—Part II

    PubMed Central

    Wright, Jane C.

    1984-01-01

    Cancer is of major concern today because of its high mortality. It is estimated that 66 million people in this country will eventually develop cancer; 1983 estimates were 855,000 new cases and 440,000 deaths from cancer. Because of limitations of surgery and radiation therapy in effecting a cure for cancer, chemotherapy has become increasingly important. The developments in the chemical control of cancer in man are encouraging. This two-part paper* covers the historical milestones in the development of the chemical and hormonal control of cancer, present successes with the use of polychemotherapy, and the hopeful trend in research. PMID:6492179

  13. Nemolizumab in moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study.

    PubMed

    Kabashima, Kenji; Furue, Masutaka; Hanifin, Jon M; Pulka, Grazyna; Wollenberg, Andreas; Galus, Ryszard; Etoh, Takafumi; Mihara, Ryosuke; Nakano, Miwa; Ruzicka, Thomas

    2018-05-09

    Nemolizumab, an anti-interleukin-31 receptor A monoclonal antibody, improved pruritus, dermatitis, and sleep in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments in a phase II, 12-week, randomized, double-blind, placebo-controlled study (Part A) (NCT01986933). To assess long-term efficacy and safety of nemolizumab injected subcutaneously every 4 weeks (Q4W) or every 8 weeks (Q8W) in a 52-week double-blind extension (Part B). During Part B, patients continued previous nemolizumab dose (0.1, 0.5, or 2.0 mg/kg Q4W or 2.0 mg/kg Q8W). Part B endpoints included percentage improvement from baseline in pruritus visual analogue scale (VAS) and dermatitis scores (including Eczema Area and Severity Index [EASI]). Overall, 216/264 patients completed Part A and 191 entered Part B; 131 completed Part B. In 153 patients randomized to nemolizumab in Part A, improvement from baseline in pruritus VAS was maintained/increased from Week 12 to 64, with greatest improvement in the 0.5-mg/kg Q4W group (percentage change from baseline at Week 64: -73.0, -89.6, -74.7, and -79.1 in the 0.1-, 0.5-, and 2.0-mg/kg Q4W and 2.0-mg/kg Q8W groups, respectively). Improvement from baseline in dermatitis scores was also maintained/increased to Week 64 (percent change in EASI score: -68.5, -75.8, -78.9, and -69.3 in the 0.1-, 0.5-, and 2.0-mg/kg Q4W and 2.0-mg/kg Q8W groups, respectively). Over 64 weeks, 83-89% had ≥1 adverse event, with no new safety concerns identified. Nemolizumab for up to 64 weeks was efficacious and, overall, well tolerated in patients with moderate-to-severe atopic dermatitis inadequately controlled by topical therapy. Copyright © 2018. Published by Elsevier Inc.

  14. Transactive System: Part II: Analysis of Two Pilot Transactive Systems using Foundational Theory and Metrics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lian, Jianming; Sun, Y.; Kalsi, Karanjit

    This document is the second of a two-part report. Part 1 reviewed several demonstrations of transactive control and compared them in terms of their payoff functions, control decisions, information privacy, and mathematical solution concepts. It was suggested in Part 1 that these four listed components should be adopted for meaningful comparison and design of future transactive systems. Part 2 proposes qualitative and quantitative metrics that will be needed to compare alternative transactive systems. It then uses the analysis and design principles from Part 1 while conducting more in-depth analysis of two transactive demonstrations: the American Electric Power (AEP) gridSMART Demonstration,more » which used a double –auction market mechanism, and a consensus method like that used in the Pacific Northwest Smart Grid Demonstration. Ultimately, metrics must be devised and used to meaningfully compare alternative transactive systems. One significant contribution of this report is an observation that the decision function used for thermostat control in the AEP gridSMART Demonstration has superior performance if its decision function is recast to more accurately reflect the power that will be used under for thermostatic control under alternative market outcomes.« less

  15. Tunable, Flexible and Efficient Optimization of Control Pulses for Superconducting Qubits, part I - Theory

    NASA Astrophysics Data System (ADS)

    Machnes, Shai; AsséMat, Elie; Tannor, David; Wilhelm, Frank

    Quantum computation places very stringent demands on gate fidelities, and experimental implementations require both the controls and the resultant dynamics to conform to hardware-specific ansatzes and constraints. Superconducting qubits present the additional requirement that pulses have simple parametrizations, so they can be further calibrated in the experiment, to compensate for uncertainties in system characterization. We present a novel, conceptually simple and easy-to-implement gradient-based optimal control algorithm, GOAT, which satisfies all the above requirements. In part II we shall demonstrate the algorithm's capabilities, by using GOAT to optimize fast high-accuracy pulses for two leading superconducting qubits architectures - Xmons and IBM's flux-tunable couplers.

  16. 18 CFR 806.25 - Water conservation standards.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., as applicable, by all classes of users. (ii) Prepare and distribute literature to customers... meters or other suitable devices or utilize acceptable flow measuring methods for accurate determination of water use by various parts of the company operation. (3) Install flow control devices which match...

  17. 18 CFR 806.25 - Water conservation standards.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., as applicable, by all classes of users. (ii) Prepare and distribute literature to customers... meters or other suitable devices or utilize acceptable flow measuring methods for accurate determination of water use by various parts of the company operation. (3) Install flow control devices which match...

  18. 18 CFR 806.25 - Water conservation standards.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., as applicable, by all classes of users. (ii) Prepare and distribute literature to customers... meters or other suitable devices or utilize acceptable flow measuring methods for accurate determination of water use by various parts of the company operation. (3) Install flow control devices which match...

  19. 75 FR 29507 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... of Commodities for Foreign Donation. OMB Control Number: 0560-0258. Summary of Collection: 7 CFR part 1496, Procurement of Processed Agricultural Commodities for Donation under Title II, Public Law 480 is... Credit Corporation (CCC) for donation overseas under various food aid authorities. The information...

  20. A Planning Guide for Instructional Networks, Part II.

    ERIC Educational Resources Information Center

    Daly, Kevin F.

    1994-01-01

    This second in a series of articles on planning for instructional computer networks focuses on site preparation, installation, service, and support. Highlights include an implementation schedule; classroom and computer lab layouts; electrical power needs; workstations; network cable; telephones; furniture; climate control; and security. (LRW)

  1. Study on Parallel 2-DOF Rotation Machanism in Radar

    NASA Astrophysics Data System (ADS)

    Jiang, Ming; Hu, Xuelong; Liu, Lei; Yu, Yunfei

    The spherical parallel machine has become the world's academic and industrial focus of the field in recent years due to its simple and economical manufacture as well as its structural compactness especially suitable for areas where space gesture changes. This paper dwells upon its present research and development home and abroad. The newer machine (RGRR-II) can rotate around the axis z within 360° and the axis y1 from -90° to +90°. It has the advantages such as less moving parts (only 3 parts), larger ratio of work space to machine size, zero mechanic coupling, no singularity. Constructing rotation machine with spherical parallel 2-DOF rotation join (RGRR-II) may realize semispherical movement with zero dead point and extent the range. Control card (PA8000NT Series CNC) is installed in the computer. The card can run the corresponding software which realizes radar movement control. The machine meets the need of radars in plane and satellite which require larger detection range, lighter weight and compacter structure.

  2. Posttraumatic stress in aging World War II survivors after a fireworks disaster: a controlled prospective study.

    PubMed

    Bramsen, Inge; van der Ploeg, Henk M; Boers, Maarten

    2006-04-01

    Little is known about the effects of cumulative trauma and whether traumatized individuals are more vulnerable. In 2000, a fireworks disaster created the possibility to examine this issue among World War II survivors who were part of an ongoing longitudinal study. Between 1998 and 2000 posttraumatic stress increased in disaster exposed respondents as opposed to the control group. War-related reexperiencing and avoidance also increased. The strongest increase occurred in disaster-exposed respondents who had low levels of wartime stress and a slight decrease occurred in those who had high wartime exposure. This unique controlled observation suggests that disasters do increase the levels of posttraumatic stress, and that reactivation of previous traumatic events generally occurs. However, the vulnerability hypothesis was not supported.

  3. 40 CFR 63.1034 - Closed vent systems and control devices; or emissions routed to a fuel gas system or process...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Closed vent systems and control devices; or emissions routed to a fuel gas system or process standards. 63.1034 Section 63.1034 Protection... stringent. The 20 parts per million by volume standard is not applicable to the provisions of § 63.1016. (ii...

  4. 40 CFR 63.1034 - Closed vent systems and control devices; or emissions routed to a fuel gas system or process...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Closed vent systems and control devices; or emissions routed to a fuel gas system or process standards. 63.1034 Section 63.1034 Protection... stringent. The 20 parts per million by volume standard is not applicable to the provisions of § 63.1016. (ii...

  5. 40 CFR 270.315 - What air emissions control information must I keep at my facility?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... specifications listed in 40 CFR 264.1084(e)(1) or (f)(1). (b) Identification of each container area subject to... or containers under requirements of 40 CFR 264.1084(d)(5) or 264.1086(e)(1)(ii). You must include... monitoring plan for both Method 21 in 40 CFR part 60, appendix A and control device monitoring methods. This...

  6. 40 CFR 270.315 - What air emissions control information must I keep at my facility?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... specifications listed in 40 CFR 264.1084(e)(1) or (f)(1). (b) Identification of each container area subject to... or containers under requirements of 40 CFR 264.1084(d)(5) or 264.1086(e)(1)(ii). You must include... monitoring plan for both Method 21 in 40 CFR part 60, appendix A and control device monitoring methods. This...

  7. 40 CFR 270.315 - What air emissions control information must I keep at my facility?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... specifications listed in 40 CFR 264.1084(e)(1) or (f)(1). (b) Identification of each container area subject to... or containers under requirements of 40 CFR 264.1084(d)(5) or 264.1086(e)(1)(ii). You must include... monitoring plan for both Method 21 in 40 CFR part 60, appendix A and control device monitoring methods. This...

  8. 40 CFR 270.315 - What air emissions control information must I keep at my facility?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... specifications listed in 40 CFR 264.1084(e)(1) or (f)(1). (b) Identification of each container area subject to... or containers under requirements of 40 CFR 264.1084(d)(5) or 264.1086(e)(1)(ii). You must include... monitoring plan for both Method 21 in 40 CFR part 60, appendix A and control device monitoring methods. This...

  9. 40 CFR 270.315 - What air emissions control information must I keep at my facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... specifications listed in 40 CFR 264.1084(e)(1) or (f)(1). (b) Identification of each container area subject to... or containers under requirements of 40 CFR 264.1084(d)(5) or 264.1086(e)(1)(ii). You must include... monitoring plan for both Method 21 in 40 CFR part 60, appendix A and control device monitoring methods. This...

  10. Tensegrity II. How structural networks influence cellular information processing networks

    NASA Technical Reports Server (NTRS)

    Ingber, Donald E.

    2003-01-01

    The major challenge in biology today is biocomplexity: the need to explain how cell and tissue behaviors emerge from collective interactions within complex molecular networks. Part I of this two-part article, described a mechanical model of cell structure based on tensegrity architecture that explains how the mechanical behavior of the cell emerges from physical interactions among the different molecular filament systems that form the cytoskeleton. Recent work shows that the cytoskeleton also orients much of the cell's metabolic and signal transduction machinery and that mechanical distortion of cells and the cytoskeleton through cell surface integrin receptors can profoundly affect cell behavior. In particular, gradual variations in this single physical control parameter (cell shape distortion) can switch cells between distinct gene programs (e.g. growth, differentiation and apoptosis), and this process can be viewed as a biological phase transition. Part II of this article covers how combined use of tensegrity and solid-state mechanochemistry by cells may mediate mechanotransduction and facilitate integration of chemical and physical signals that are responsible for control of cell behavior. In addition, it examines how cell structural networks affect gene and protein signaling networks to produce characteristic phenotypes and cell fate transitions during tissue development.

  11. Transdermal rotigotine in early stage Parkinson's disease: a randomized, double-blind, placebo-controlled trial.

    PubMed

    Mizuno, Yoshikuni; Nomoto, Masahiro; Kondo, Tomoyoshi; Hasegawa, Kazuko; Murata, Miho; Takeuchi, Masahiro; Ikeda, Junji; Tomida, Takayuki; Hattori, Nobutaka

    2013-09-01

    We conducted a randomized, double-blind, placebo-controlled trial to determine the safety and efficacy of transdermal rotigotine at doses up to 16 mg/24 hours in patients with early stage Parkinson's disease (PD) in Japan. Patients received once-daily rotigotine 2 to 16 mg/24 hours (mean dose, 12.8 mg/24 hours; n = 82) or placebo (n = 90) for 12 weeks. The primary endpoint was the change in Unified Parkinson's Disease Rating Scale (UPDRS) part II (activities of daily living) and part III (motor function) scores from baseline to the end of treatment. The mean (± standard deviation) changes in UPDRS part II and III scores were -8.4 ± 9.7 in the rotigotine group and -4.1 ± 8.2 in the placebo group and were significantly different (P = 0.002). More patients in the rotigotine group than in the placebo group had a ≥ 20% score reduction. No serious drug-related adverse events were reported. Rotigotine at doses up to 16 mg/24 hours was well tolerated and improved function in patients with early stage PD. © 2013 International Parkinson and Movement Disorder Society.

  12. Transcutaneous electrical nerve stimulation reduces exercise-induced perceived pain and improves endurance exercise performance.

    PubMed

    Astokorki, Ali H Y; Mauger, Alexis R

    2017-03-01

    Muscle pain is a natural consequence of intense and prolonged exercise and has been suggested to be a limiter of performance. Transcutaneous electrical nerve stimulation (TENS) and interferential current (IFC) have been shown to reduce both chronic and acute pain in a variety of conditions. This study sought to ascertain whether TENS and IFC could reduce exercise-induced pain (EIP) and whether this would affect exercise performance. It was hypothesised that TENS and IFC would reduce EIP and result in an improved exercise performance. In two parts, 18 (Part I) and 22 (Part II) healthy male and female participants completed an isometric contraction of the dominant bicep until exhaustion (Part I) and a 16.1 km cycling time trial as quickly as they could (Part II) whilst receiving TENS, IFC, and a SHAM placebo in a repeated measures, randomised cross-over, and placebo-controlled design. Perceived EIP was recorded in both tasks using a validated subjective scale. In Part I, TENS significantly reduced perceived EIP (mean reduction of 12%) during the isometric contraction (P = 0.006) and significantly improved participants' time to exhaustion by a mean of 38% (P = 0.02). In Part II, TENS significantly improved (P = 0.003) participants' time trial completion time (~2% improvement) through an increased mean power output. These findings demonstrate that TENS can attenuate perceived EIP in a healthy population and that doing so significantly improves endurance performance in both submaximal isometric single limb exercise and whole-body dynamic exercise.

  13. Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression

    PubMed Central

    Gehrand, Ashley; Bruder, Eric D.; Hoffman, Matthew J.; Engeland, William C.; Moreno, Carol

    2014-01-01

    The classic renin-angiotensin system is partly responsible for controlling aldosterone secretion from the adrenal cortex via the peptide angiotensin II (ANG II). In addition, there is a local adrenocortical renin-angiotensin system that may be involved in the control of aldosterone synthesis in the zona glomerulosa (ZG). To characterize the long-term control of adrenal steroidogenesis, we utilized adrenal glands from renin knockout (KO) rats and compared steroidogenesis in vitro and steroidogenic enzyme expression to wild-type (WT) controls (Dahl S rat). Adrenal capsules (ZG; aldosterone production) and subcapsules [zona reticularis/fasciculata (ZFR); corticosterone production] were separately dispersed and studied in vitro. Plasma renin activity and ANG II concentrations were extremely low in the KO rats. Basal and cAMP-stimulated aldosterone production was significantly reduced in renin KO ZG cells, whereas corticosterone production was not different between WT and KO ZFR cells. As expected, adrenal renin mRNA expression was lower in the renin KO compared with the WT rat. Real-time PCR and immunohistochemical analysis showed a significant decrease in P450aldo (Cyp11b2) mRNA and protein expression in the ZG from the renin KO rat. The reduction in aldosterone synthesis in the ZG of the renin KO adrenal seems to be accounted for by a specific decrease in P450aldo and may be due to the absence of chronic stimulation of the ZG by circulating ANG II or to a reduction in locally released ANG II within the adrenal gland. PMID:25394830

  14. 7 CFR 275.2 - State agency responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...: (i) Data collection through management evaluation (ME) reviews and quality control (QC) reviews; (ii... knowledge of either the household or the decision under review. Where there is prior knowledge, the reviewer must disqualify her/himself. Prior knowledge is defined as having: (1) Taken any part in the decision...

  15. 7 CFR 275.2 - State agency responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...: (i) Data collection through management evaluation (ME) reviews and quality control (QC) reviews; (ii... knowledge of either the household or the decision under review. Where there is prior knowledge, the reviewer must disqualify her/himself. Prior knowledge is defined as having: (1) Taken any part in the decision...

  16. 7 CFR 275.2 - State agency responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...: (i) Data collection through management evaluation (ME) reviews and quality control (QC) reviews; (ii... knowledge of either the household or the decision under review. Where there is prior knowledge, the reviewer must disqualify her/himself. Prior knowledge is defined as having: (1) Taken any part in the decision...

  17. 7 CFR 275.2 - State agency responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...: (i) Data collection through management evaluation (ME) reviews and quality control (QC) reviews; (ii... knowledge of either the household or the decision under review. Where there is prior knowledge, the reviewer must disqualify her/himself. Prior knowledge is defined as having: (1) Taken any part in the decision...

  18. 40 CFR 52.232 - Part D conditional approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... IX office). (ii) By January 1, 1981, a cutback asphalt rule which reflects reasonably available... SIP revision: (a) Adequate justification that the cutback asphalt rule represents RACT, (b) amendment of the cutback asphalt rule to conform with the controls recommended in the CTG document for cutback...

  19. 21 CFR 866.5735 - Prothrombin immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... factor II) in serum. Measurements of the amount of antigenically competent (ability to react with protein antibodies) prothrombin aid in the diagnosis of blood-clotting disorders. (b) Classification. Class I (general controls). The device is exempt from the premarket notification procedures in subpart E of part...

  20. 24 CFR 51.101 - General policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.101 General policy. (a) It is HUD's..., highways and other sources of high noise. (ii) Applicants shall take into consideration HUD environmental... under 24 CFR part 58 must take into consideration the noise criteria and standards in the environmental...

  1. Airport Surface Traffic Control Concept Formulation Study : Volume II. Operations Analysis of O'Hare Airport - Part 1

    DOT National Transportation Integrated Search

    1975-07-01

    The report describes the approach followed and the analysis techniques employed in the performance of the operations analysis of the current ASTC system for the baseline airport, O'Hare International Airport, Chicago, Illinois. It also describes the ...

  2. General Methodology Combining Engineering Optimization of Primary HVAC and R Plants with Decision Analysis Methods--Part II: Uncertainty and Decision Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jiang, Wei; Reddy, T. A.; Gurian, Patrick

    2007-01-31

    A companion paper to Jiang and Reddy that presents a general and computationally efficient methodology for dyanmic scheduling and optimal control of complex primary HVAC&R plants using a deterministic engineering optimization approach.

  3. 7 CFR 275.2 - State agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...: (i) Data collection through management evaluation (ME) reviews and quality control (QC) reviews; (ii... knowledge of either the household or the decision under review. Where there is prior knowledge, the reviewer must disqualify her/himself. Prior knowledge is defined as having: (1) Taken any part in the decision...

  4. Technical Information on the Carbonation of the EBR-II Reactor, Summary Report Part 2: Application to EBR-II Primary Sodium System and Related Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steven R. Sherman; Collin J. Knight

    Residual sodium is defined as sodium metal that remains behind in pipes, vessels, and tanks after the bulk sodium metal has been melted and drained from such components. The residual sodium has the same chemical properties as bulk sodium, and differs from bulk sodium only in the thickness of the sodium deposit. Typically, sodium is considered residual when the thickness of the deposit is less than 5-6 cm. This residual sodium must be removed or deactivated when a pipe, vessel, system, or entire reactor is permanently taken out of service, in order to make the component or system safer and/ormore » to comply with decontamination and decomissioning regulations. As an alternative to the established residual sodium deactivation techniques (steam-and-nitrogen, wet vapor nitrogen, etc.), a technique involving the use of moisture and carbon dioxide has been developed. With this technique, sodium metal is converted into sodium bicarbonate by reacting it with humid carbon dioxide. Hydrogen is emitted as a by-product. This technique was first developed in the laboratory by exposing sodium samples to humidifed carbon dioxide under controlled conditions, and then demonstrated on a larger scale by treating residual sodium within the Experimental Breeder Reactor II (EBR-II) secondary cooling system, followed by the primary cooling system, respectively. The EBR-II facility is located at the Idaho National Laboratory (INL) in southeastern Idaho, USA. This report is Part 2 of a two-part report. This second report provides a supplement to the first report and describes the application of the humdidified carbon dioxide technique ("carbonation") to the EBR-II primary tank, primary cover gas systems, and the intermediate heat exchanger. Future treatment plans are also provided.« less

  5. Exoskeletal meal assistance system (EMAS II) for progressive muscle dystrophy patient.

    PubMed

    Hasegawa, Yasuhisa; Oura, Saori

    2011-01-01

    This paper introduces a 4-DOFs exoskeletal meal assistance system (EMAS II) for progressive muscle dystrophy patient. It is generally better for the patient to use his/her hands by himself in daily life because active works maintain level of residual functions, health and initiative of him/her. The EMAS II that has a new joystick-type user interface device and three-DOFs on a shoulder part is enhanced for an easier operation and more comfortable support on eating, as the succeeding model of the previous system that has two-DOFs on a shoulder. In order to control the 4-DOFs system by the simple user interface device, the EMAS II simulates upper limb motion patterns of a healthy person. The motion patterns are modeled by extracting correlations between the height of a user's wrist joint and that of the user's elbow joint at the table. Moreover, the EMAS II automatically brings user's hand up to his/her mouth or back to a table when he/she pushes a preset switch on the interface device. Therefore a user has only to control a position of his/her wrist to pick or scoop foods and then flip the switch to start automatic mode, while a height of the elbow joint is automatically controlled by the EMAS II itself. The results of experiments, where a healthy subject regarded as a muscle dystrophy patient eats a meal with EMAS II, show that the subject finished her meal in a natural way in 18 minutes 40 seconds which was within a recommended time of 30 minutes. © 2011 IEEE

  6. NASA Remembers Astronaut Bruce McCandless II

    NASA Image and Video Library

    2017-12-22

    Former NASA Astronaut Bruce McCandless II, best known for his iconic free-floating spacewalk on a 1984 shuttle flight, died on Dec. 21 at the age of 80. A native of Boston, McCandless II attended the U.S. Naval Academy and served as a naval aviator before joining NASA in 1966. He served in support or backup roles during the Apollo and Skylab programs, including serving as the communicator from mission control to the Apollo 11 crew during their historic 1969 moonwalk. On Feb. 7, 1984, during the Space Shuttle Challenger’s STS-41B mission, he made the first, untethered, free flight spacewalk in the Manned Maneuvering Unit. In 1990, McCandless II was part of the crew on Space Shuttle Discovery’s STS-31 mission, which deployed the Hubble Space Telescope.

  7. CMIF ECLS system test findings

    NASA Technical Reports Server (NTRS)

    Schunk, Richard G.; Carrasquillo, Robyn L.; Ogle, Kathyrn Y.; Wieland, Paul O.; Bagdigian, Robert M.

    1989-01-01

    During 1987 three Space Station integrated Environmental Control and Life Support System (ECLSS) tests were conducted at the Marshall Space Flight Center (MSFC) Core Module Integration Facility (CMIF) as part of the MSFC ECLSS Phase II test program. The three tests ranged in duration from 50 to 150 hours and were conducted inside of the CMIF module simulator. The Phase II partial integrated system test configuration consisted of four regenerative air revitalization subsystems and one regenerative water reclamation subsystem. This paper contains a discussion of results and lessons learned from the Phase II test program. The design of the Phase II test configuration and improvements made throughout the program are detailed. Future plans for the MSFC CMIF test program are provided, including an overview of planned improvements for the Phase III program.

  8. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

  9. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

  10. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

  11. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

  12. 40 CFR Appendixes I-Ii to Part 268 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false [Reserved] I Appendixes I-II to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) LAND DISPOSAL RESTRICTIONS Appendixes I-II to Part 268 [Reserved] ...

  13. Technical Information on the Carbonation of the EBR-II Reactor, Summary Report Part 1: Laboratory Experiments and Application to EBR-II Secondary Sodium System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steven R. Sherman

    Residual sodium is defined as sodium metal that remains behind in pipes, vessels, and tanks after the bulk sodium metal has been melted and drained from such components. The residual sodium has the same chemical properties as bulk sodium, and differs from bulk sodium only in the thickness of the sodium deposit. Typically, sodium is considered residual when the thickness of the deposit is less than 5-6 cm. This residual sodium must be removed or deactivated when a pipe, vessel, system, or entire reactor is permanently taken out of service, in order to make the component or system safer and/ormore » to comply with decommissioning regulations. As an alternative to the established residual sodium deactivation techniques (steam-and-nitrogen, wet vapor nitrogen, etc.), a technique involving the use of moisture and carbon dioxide has been developed. With this technique, sodium metal is converted into sodium bicarbonate by reacting it with humid carbon dioxide. Hydrogen is emitted as a by-product. This technique was first developed in the laboratory by exposing sodium samples to humidified carbon dioxide under controlled conditions, and then demonstrated on a larger scale by treating residual sodium within the Experimental Breeder Reactor II (EBR-II) secondary cooling system, followed by the primary cooling system, respectively. The EBR-II facility is located at the Idaho National Laboratory (INL) in southeastern Idaho, U.S.A. This report is Part 1 of a two-part report. It is divided into three sections. The first section describes the chemistry of carbon dioxide-water-sodium reactions. The second section covers the laboratory experiments that were conducted in order to develop the residual sodium deactivation process. The third section discusses the application of the deactivation process to the treatment of residual sodium within the EBR-II secondary sodium cooling system. Part 2 of the report, under separate cover, describes the application of the technique to residual sodium treatment within the EBR-II primary sodium cooling system and related systems.« less

  14. Sensors, Volume 3, Part II, Chemical and Biochemical Sensors Part II

    NASA Astrophysics Data System (ADS)

    Göpel, Wolfgang; Jones, T. A.; Kleitz, Michel; Lundström, Ingemar; Seiyama, Tetsuro

    1997-06-01

    'Sensors' is the first self-contained series to deal with the whole area of sensors. It describes general aspects, technical and physical fundamentals, construction, function, applications and developments of the various types of sensors. This is the second of two volumes focusing on chemical and biochemical sensors. It includes a detailed description of biosensors which often make use of transducer properties of the basic sensors and usually have additional biological components. This volume provides a unique overview of the applications, the possibilities and limitations of sensors in comparison with conventional instrumentation in analytical chemistry. Specific facettes of applications are presented by specialists from different fields including environmental, biotechnological, medical, or chemical process control. This book is an indispensable reference work for both specialits and newcomers, researchers and developers.

  15. Stability Improvement of High-Pressure-Ratio Turbocharger Centrifugal Compressor by Asymmetrical Flow Control-Part II: Nonaxisymmetrical Self-Recirculation Casing Treatment.

    PubMed

    Zheng, Xinqian; Zhang, Yangjun; Yang, Mingyang; Bamba, Takahiro; Tamaki, Hideaki

    2013-03-01

    This is part II of a two-part paper involving the development of an asymmetrical flow control method to widen the operating range of a turbocharger centrifugal compressor with high-pressure ratio. A nonaxisymmetrical self-recirculation casing treatment (SRCT) as an instance of asymmetrical flow control method is presented. Experimental and numerical methods were used to investigate the impact of nonaxisymmetrical SRCT on the surge point of the centrifugal compressor. First, the influence of the geometry of a symmetric SRCT on the compressor performance was studied by means of numerical simulation. The key parameter of the SRCT was found to be the distance from the main blade leading edge to the rear groove (S r ). Next, several arrangements of a nonaxisymmetrical SRCT were designed, based on flow analysis presented in part I. Then, a series of experiments were carried out to analyze the influence of nonaxisymmetrical SRCT on the compressor performance. Results show that the nonaxisymmetrical SRCT has a certain influence on the performance and has a larger potential for stability improvement than the traditional symmetric SRCT. For the investigated SRCT, the surge flow rate of the compressor with the nonaxisymmetrical SRCTs is about 10% lower than that of the compressor with symmetric SRCT. The largest surge margin (smallest surge flow rate) can be obtained when the phase of the largest S r is coincident with the phase of the minimum static pressure in the vicinity of the leading edge of the splitter blades.

  16. 30 CFR 914.30 - State-Federal Cooperative Agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

  17. 30 CFR 914.30 - State-Federal Cooperative Agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

  18. 30 CFR 914.30 - State-Federal Cooperative Agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

  19. 30 CFR 914.30 - State-Federal Cooperative Agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

  20. 30 CFR 914.30 - State-Federal Cooperative Agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....C. 4321 et seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species.... Authority This Agreement is authorized by section 523(c) of the Surface Mining Control and Reclamation Act.... Article II: Effective Date After being signed by the Secretary and the Governor, this Agreement will take...

  1. The Hatch Amendment: A Primer for Counselors, Part II.

    ERIC Educational Resources Information Center

    Kaplan, Leslie S.; Geoffroy, Kevin

    1987-01-01

    Explores the legislative decisions concerning parental versus state control of education in light of the Hatch Amendment. Suggests ways for educators and counselors to deal with the amendment by recognizing limitations of the amendment, developing procedures for determining when written parental consent is required, and developing and publishing a…

  2. Syllabus in Trade Electricity-Electronics. Section II. Trade Electricity.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Occupational Education Curriculum Development.

    This second section of a three-part syllabus for a flexible curriculum in trade electricity-electronics contains four semi-independent units: (1) Advanced Electricity, (2) Residential and Commercial Wiring, (3) Industrial Electricity, and (4) Motor Controls. Introductory sections describe development of the curriculum, outline the total trade…

  3. 12 CFR Appendix A to Part 325 - Statement of Policy on Risk-Based Capital

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... qualifying and excess capital, calculate risk-weighted assets, calculate market risk equivalent assets and... and control financial and operating risks, including the risk presented by concentrations of credit....(6)(ii) of this appendix A), and subsidiaries that are engaged in non-financial activities are not...

  4. 29 CFR 1910.181 - Derricks.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... avoid carrying loads over people. (vii) The operator shall test the brakes each time a load approaching... base supported by ropes attached to corner posts or other parts of the structure. The base is at a... safety hazard: (i) All control mechanisms: Inspect daily for adjustment, wear, and lubrication. (ii) All...

  5. 29 CFR 1910.181 - Derricks.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... avoid carrying loads over people. (vii) The operator shall test the brakes each time a load approaching... base supported by ropes attached to corner posts or other parts of the structure. The base is at a... safety hazard: (i) All control mechanisms: Inspect daily for adjustment, wear, and lubrication. (ii) All...

  6. 29 CFR 1910.181 - Derricks.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... avoid carrying loads over people. (vii) The operator shall test the brakes each time a load approaching... base supported by ropes attached to corner posts or other parts of the structure. The base is at a... safety hazard: (i) All control mechanisms: Inspect daily for adjustment, wear, and lubrication. (ii) All...

  7. 29 CFR 1910.181 - Derricks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... avoid carrying loads over people. (vii) The operator shall test the brakes each time a load approaching... base supported by ropes attached to corner posts or other parts of the structure. The base is at a... safety hazard: (i) All control mechanisms: Inspect daily for adjustment, wear, and lubrication. (ii) All...

  8. 15 CFR Supplement No. 2 to Part 730 - Technical Advisory Committees

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... utilization of production technology; licensing procedures that affect the level of export controls applicable... questions involving technical matters, worldwide availability and actual utilization of production and... of U.S. producers of such items; and (ii) The volume of annual production by such persons or firms of...

  9. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... Indian Reservation consists of a prohibition of all Class I, II, III and IV injection wells and of a... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...

  10. 40 CFR 147.2404 - EPA-administered program-Colville Reservation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) WATER PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS... Indian Reservation consists of a prohibition of all Class I, II, III and IV injection wells and of a... CFR part 124, 144 and 146 and any additional requirements set forth in the remainder of this subpart...

  11. 25 CFR 543.7 - What are the minimum internal control standards for bingo?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... software upgrades, data storage media replacement, etc.). The information recorded must be used when...., draw objects and back-up draw objects); and (ii) Random number generator software. (Additional information technology security standards can be found in § 543.16 of this part.) (2) The game software...

  12. 25 CFR 543.7 - What are the minimum internal control standards for bingo?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... software upgrades, data storage media replacement, etc.). The information recorded must be used when...., draw objects and back-up draw objects); and (ii) Random number generator software. (Additional information technology security standards can be found in § 543.16 of this part.) (2) The game software...

  13. 25 CFR 161.2 - What are the Secretary's authorities under this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., 1980: (i) All conservation practices on the Navajo Partitioned Lands, including control and range restoration activities, must be coordinated and executed with the concurrence of the Navajo Nation; and (ii) All grazing and range restoration matters on the Navajo Reservation lands must be administered by BIA...

  14. 12 CFR Appendix A to Part 325 - Statement of Policy on Risk-Based Capital

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... qualifying and excess capital, calculate risk-weighted assets, calculate market risk equivalent assets and... and control financial and operating risks, including the risk presented by concentrations of credit....(6)(ii) of this appendix A), and subsidiaries that are engaged in non-financial activities are not...

  15. 12 CFR Appendix A to Part 325 - Statement of Policy on Risk-Based Capital

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... qualifying and excess capital, calculate risk-weighted assets, calculate market risk equivalent assets and... and control financial and operating risks, including the risk presented by concentrations of credit....(6)(ii) of this appendix A), and subsidiaries that are engaged in non-financial activities are not...

  16. 12 CFR Appendix A to Part 325 - Statement of Policy on Risk-Based Capital

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... qualifying and excess capital, calculate risk-weighted assets, calculate market risk equivalent assets and... and control financial and operating risks, including the risk presented by concentrations of credit....(6)(ii) of this appendix A), and subsidiaries that are engaged in non-financial activities are not...

  17. 76 FR 38203 - Proposed Information Collection; North American Woodcock Singing Ground Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ...] Proposed Information Collection; North American Woodcock Singing Ground Survey AGENCY: Fish and Wildlife... populations. The North American Woodcock Singing Ground Survey is an essential part of the migratory bird.... II. Data OMB Control Number: 1018-0019. Title: North American Woodcock Singing Ground Survey. Service...

  18. 40 CFR 721.5 - Persons who must report.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Persons who must report. 721.5 Section 721.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... new uses. (ii) That the recipient has knowledge of the specific section in subpart E of this part...

  19. BOOK REVIEW "LAKE ERIE REHABILITATED: CONTROLLING CULTURAL EUTROPHICATION, 1960S - 1990S"

    EPA Science Inventory

    This well written, well researched and informative book recounts the sudden appearance of cultural eutrophication in the Great Lakes after adoption of phosphorous as the main active ingredient in detergents toward the end of World War II. For the most part, McGucken, a historian,...

  20. 32 CFR Appendix C to Part 290 - For Official Use Only

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... limited within the FAO to one protected office copy. (3) Storage. (i) All Field Detachment sensitive... container controlled by the FAO manager. (ii) Permanent files currently maintained by regular DCAA offices, which are available to all FAO personnel, should not contain any detailed information on Field...

  1. The efficacy of fluorocarbon, surfactant, and their combination for improving acute lung injury induced by intratracheal acidified infant formula.

    PubMed

    Nishina, Kahoru; Mikawa, Katsuya; Takao, Yumiko; Obara, Hidefumi

    2005-04-01

    We conducted the current study to compare the efficacy of partial liquid ventilation (PLV), pulmonary surfactant (PSF), and their combination in ameliorating the acidified infant-formula-induced acute lung injury (ALI). In the Part I study, 42 rabbits receiving volume-controlled ventilation with positive end-expiratory pressure 10 cm H(2)O were randomly divided into 6 groups (groups noninjuryI, gas ventilation [GVi], PLVi, PSFi, PLVi-->PSFi, and PSFi-->PLVi). ALI was induced by intratracheal acidified infant formula (2 mL/kg, pH 1.8). Group GVi received neither PLV nor PSF therapy. Groups PLV and PSF received intratracheal fluorocarbon 15 mL/kg or surfactant 100 mg/kg, respectively, 30 min after acidified infant formula. Groups PLVi-->PSFi and PSFi-->PLVi received both treatments at 30-min intervals. In Part II, 42 rabbits (in 6 groups) undergoing pressure-controlled ventilation received the same drug therapies as in Part I. The lungs were excised to assess biochemical and histological damage 150 min after induction of ALI. In Parts I and II, PSF, fluorocarbon, and their combination attenuated lung leukosequestration and edema and superoxide production of neutrophils, consequently improving oxygenation, lung mechanics, and pathological changes. Independent of ventilation mode, PSF followed by fluorocarbon provided the most beneficial effects and fluorocarbon followed by PSF produced the least efficacy.

  2. CICADA -- Configurable Instrument Control and Data Acquisition

    NASA Astrophysics Data System (ADS)

    Young, Peter J.; Roberts, William H.; Sebo, Kim M.

    CICADA (Young et al. 1997) is a multi-process, distributed application for the control of astronomical data acquisition systems. It comprises elements that control the operation of, and data flow from CCD camera systems; and the operation of telescope instrument control systems. CICADA can be used to dynamically configure support for astronomical instruments that can be made up of multiple cameras and multiple instrument controllers. Each camera is described by a hierarchy of parts that are each individually configured and linked together. Most of CICADA is written in C++ and much of the configurability of CICADA comes from the use of inheritance and polymorphism. An example of a multiple part instrument configuration -- a wide field imager (WFI) -- is described here. WFI, presently under construction, is made up of eight 2k x 4k CCDs with dual SDSU II controllers and will be used at Siding Spring's ANU 40in and AAO 3.9m telescopes.

  3. An Analysis of a Finite Element Method for Convection-Diffusion Problems. Part II. A Posteriori Error Estimates and Adaptivity.

    DTIC Science & Technology

    1983-03-01

    AN ANALYSIS OF A FINITE ELEMENT METHOD FOR CONVECTION- DIFFUSION PROBLEMS PART II: A POSTERIORI ERROR ESTIMATES AND ADAPTIVITY by W. G. Szymczak Y 6a...PERIOD COVERED AN ANALYSIS OF A FINITE ELEMENT METHOD FOR final life of the contract CONVECTION- DIFFUSION PROBLEM S. Part II: A POSTERIORI ERROR ...Element Method for Convection- Diffusion Problems. Part II: A Posteriori Error Estimates and Adaptivity W. G. Szvmczak and I. Babu~ka# Laboratory for

  4. DIVWAG Model Documentation. Volume II. Programmer/Analyst Manual. Part 3. Chapter 9 Through 12.

    DTIC Science & Technology

    1976-07-01

    entered through a routine, NAM2, that calls the segment controlling routine NBARAS. (4) Segment 3, controlled by the routine NFIRE , simulates round...nuclear fire, NAM calls in sequence the routines NFIRE (segment 3), ASUNIT (segment 2), SASSMT (segment 4), and NFIRE (segment 3). These calls simulate...this is a call to NFIRE (ISEG equals one or two), control goes to block L2. (2) Block 2. If this is to assess a unit passing through a nuclear barrier

  5. Design and Analysis of A Multi-Backend Database System for Performance Improvement, Functionality Expansion and Capacity Growth. Part II.

    DTIC Science & Technology

    1981-08-01

    of Transactions ..... . 29 5.5.2 Attached Execution of Transactions ........ ... 29 5.5.3 The Choice of Transaction Execution for Access Control...basic access control mech- anism for statistical security and value-dependent security. In Section 5.5, * we describe the process of execution of ...the process of request execution with access control for in- sert and non-insert requests in MDBS. We recall again (see Chapter 4) that the process

  6. Analysis of the Large Urban Fire Environment. Part II. Parametric Analysis and Model City Simulations.

    DTIC Science & Technology

    1982-11-01

    algorithm for turning-region boundary value problem -70- d. Program control parameters: ALPHA (Qq) max’ maximum value of Qq in present coding. BETA, BLOSS...Parameters available for either system descrip- tion or program control . (These parameters are currently unused, so they are set equal to zero.) IGUESS...Parameter that controls the initial choices of first-shoot values along y = 0. IGUESS = 1: Discretized versions of P(r, 0), T(r, 0), and u(r, 0) must

  7. Identification and characterization of glycosyltransferases involved in the synthesis of the side chains of the cell wall pectic polysaccharide rhamnogalacturonan II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    O'Neill, Malcolm

    Our goal was to gain insight into the genes and proteins involved in the biosynthesis of rhamnogalacturonan II (RG-II), a borate cross-linked and structurally conserved pectic polysaccharide present in the primary cell walls of all vascular plants. The research conducted during the funding period established that (i) Avascular plants have the ability to synthesize UDP-apiose but lack the glycosyltransferase machinery required to synthesize RG-II or other apiose-containing cell wall glycans. (ii) RG-II structure is highly conserved in the Lemnaceae (duckweeds and relatives). However, the structures of other wall pectins and hemicellulose have changed substantial during the diversification of the Lemnaceae.more » This supports the notion that a precise structure of RG-II must be maintained to allow borate cross-linking to occur in a controlled manner. (iii) Enzymes involved in the conversion of UDP-GlcA to UDP-Api, UDP-Xyl, and UDP-Ara may have an important role in controlling the composition of duckweed cell walls. (iv) RG-II exists as the borate ester cross-linked dimer in the cell walls of soybean root hairs and roots. Thus, RG-II is present in the walls of plants cells that grow by tip or by expansive growth. (v) A reduction in RG-II cross-linking in the maize tls1 mutant, which lacks a borate channel protein, suggests that the growth defects observed in the mutant are, at least in part, due to defects in the cell wall.« less

  8. The SHEFEX II Thermal Protection System

    NASA Astrophysics Data System (ADS)

    Bohrk, H.; Elsaber, H.; Weihs, H.

    2011-05-01

    The SHEFEXII payload tip is ready for flight. Within a period of three years, the experiment has been designed, laid out, parts have been manufactured, mounted and instrumented for the upcoming flight in autumn 2011. The present paper gives an overview over the thermal protection system (TPS) of the SHEFEX II vehicle including the TPS-material, the overall TPS-setup, and detailed informations on the faceted ther- mal protection including the gap seal, the sharp leading edge, the transpiration-cooling experiment AKTIV, and the aerodynamic control surfaces, i.e. canards.

  9. Development of autonomous eating mechanism for biomimetic robots

    NASA Astrophysics Data System (ADS)

    Jeong, Kil-Woong; Cho, Ik-Jin; Lee, Yun-Jung

    2005-12-01

    Most of the recently developed robots are human friendly robots which imitate animals or humans such as entertainment robot, bio-mimetic robot and humanoid robot. Interest for these robots are being increased because the social trend is focused on health, welfare, and graying. Autonomous eating functionality is most unique and inherent behavior of pets and animals. Most of entertainment robots and pet robots make use of internal-type battery. Entertainment robots and pet robots with internal-type battery are not able to operate during charging the battery. Therefore, if a robot has an autonomous function for eating battery as its feeds, the robot is not only able to operate during recharging energy but also become more human friendly like pets. Here, a new autonomous eating mechanism was introduced for a biomimetic robot, called ELIRO-II(Eating LIzard RObot version 2). The ELIRO-II is able to find a food (a small battery), eat and evacuate by itself. This work describe sub-parts of the developed mechanism such as head-part, mouth-part, and stomach-part. In addition, control system of autonomous eating mechanism is described.

  10. Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats.

    PubMed

    Vanourková, Z; Kramer, H J; Husková, Z; Cervenka, L; Vanecková, I

    2010-01-01

    The relationship between angiotensin II (ANG II) and endothelin-1 (ET-1) is known to be complex; both peptides can initiate and potentiate the gene expression of each other. This pilot study investigated the effects of the AT(1) receptor blocker losartan or the direct renin inhibitor aliskiren on mean arterial pressure (MAP) and albuminuria and the renal ANG II and ET-1 levels. 3-month-old male Ren-2 transgenic rats (TGR) were treated either with losartan (5 mg kg(-1) day(-1)) or aliskiren (10 mg kg(-1) day(-1)) for 10 weeks. At the end of the experiment, rats were decapitated and cortical and papillary parts of kidneys were separated. Plasma and tissue ANG II levels were measured by RIA and tissue ET-1 concentrations by ELISA. In all four groups of animals ET-1 levels were lowest in renal cortex and more than 100-fold higher in the papilla. Cortical and papillary ET-1 concentrations in untreated TGR significantly exceeded those of control HanSD rats and were significantly depressed by both drugs. In both strains, papillary ANG II concentrations were moderately but significantly higher than cortical ANG II, TGR exhibited higher ANG II levels both in cortex and papilla as compared to control HanSD rats. Aliskiren and losartan at the doses used depressed similarly the levels of ANG II in cortex and papilla and reduced ET-1 significantly in the renal cortex and papilla below control levels in HanSD rats. Albuminuria, which was more than twice as high in TGR as in HanSD rats, was normalized with aliskiren and reduced by 28% with losartan, although MAP was reduced to a similar degree by both drugs. Despite similar reductions of MAP and renal ET-1 and ANG II levels aliskiren appears to be more effective than losartan, at the doses used, in reducing albuminuria in heterozygous hypertensive Ren-2 rats.

  11. p21 Activated Kinase 5 Activates Raf-1 and Targets it to Mitochondria

    PubMed Central

    Wu, Xiaochong; Carr, Heather S.; Dan, Ippeita; Ruvolo, Peter P.; Frost, Jeffrey A.

    2008-01-01

    Raf-1 is an important effector of Ras mediated signaling and is a critical regulator of the ERK/MAPK pathway. Raf-1 activation is controlled in part by phosphorylation on multiple residues, including an obligate phosphorylation site at serine 338. Previously PAK1 and casein kinase II have been implicated as serine 338 kinases. To identify novel kinases that phosphorylate this site, we tested the ability of group II PAKs (PAKs 4-6) to control serine 338 phosphorylation. We observed that all group II PAKs were efficient serine 338 kinases, although only PAK1 and PAK5 significantly stimulated Raf-1 kinase activity. We also showed that PAK5 forms a tight complex with Raf-1 in the cell, but not A-Raf or B-Raf. Importantly, we also demonstrated that the association of Raf-1 with PAK5 targets a subpopulation of Raf-1 to mitochondria. These data indicate that PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at the mitochondria. PMID:18465753

  12. A Survey of Optometry Graduates to Determine Practice Patterns: Part II: Licensure and Practice Establishment Experiences.

    ERIC Educational Resources Information Center

    Bleimann, Robert L.; Smith, Lee W.

    1985-01-01

    A summary of Part II of a two-volume study of optometry graduates conducted by the Association of Schools and Colleges of Optometry is presented. Part II includes the analysis of the graduates' licensure and practice establishment experiences. (MLW)

  13. Market-Based Coordination of Thermostatically Controlled Loads—Part I: A Mechanism Design Formulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Sen; Zhang, Wei; Lian, Jianming

    This paper focuses on the coordination of a population of Thermostatically Controlled Loads (TCLs) with unknown parameters to achieve group objectives. The problem involves designing the bidding and market clearing strategy to motivate self-interested users to realize efficient energy allocation subject to a peak power constraint. Using the mechanism design approach, we propose a market-based coordination framework, which can effectively incorporate heterogeneous load dynamics, systematically deal with user preferences, account for the unknown load model parameters, and enable the real-world implementation with limited communication resources. This paper is divided into two parts. Part I presents a mathematical formulation of themore » problem and develops a coordination framework using the mechanism design approach. Part II presents a learning scheme to account for the unknown load model parameters, and evaluates the proposed framework through realistic simulations.« less

  14. Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes.

    PubMed

    Li, Yuwei; Ahrens, Molly J; Wu, Amy; Liu, Jennifer; Dudley, Andrew T

    2011-01-01

    For tissues that develop throughout embryogenesis and into postnatal life, the generation of differentiated cells to promote tissue growth is at odds with the requirement to maintain the stem cell/progenitor cell population to preserve future growth potential. In the growth plate cartilage, this balance is achieved in part by establishing a proliferative phase that amplifies the number of progenitor cells prior to terminal differentiation into hypertrophic chondrocytes. Here, we show that endogenous calcium/calmodulin-dependent protein kinase II (CamkII, also known as Camk2) activity is upregulated prior to hypertrophy and that loss of CamkII function substantially blocks the transition from proliferation to hypertrophy. Wnt signaling and Pthrp-induced phosphatase activity negatively regulate CamkII activity. Release of this repression results in activation of multiple effector pathways, including Runx2- and β-catenin-dependent pathways. We present an integrated model for the regulation of proliferation potential by CamkII activity that has important implications for studies of growth control and adult progenitor/stem cell populations.

  15. An FPGA- Based General-Purpose Data Acquisition Controller

    NASA Astrophysics Data System (ADS)

    Robson, C. C. W.; Bousselham, A.; Bohm

    2006-08-01

    System development in advanced FPGAs allows considerable flexibility, both during development and in production use. A mixed firmware/software solution allows the developer to choose what shall be done in firmware or software, and to make that decision late in the process. However, this flexibility comes at the cost of increased complexity. We have designed a modular development framework to help to overcome these issues of increased complexity. This framework comprises a generic controller that can be adapted for different systems by simply changing the software or firmware parts. The controller can use both soft and hard processors, with or without an RTOS, based on the demands of the system to be developed. The resulting system uses the Internet for both control and data acquisition. In our studies we developed the embedded system in a Xilinx Virtex-II Pro FPGA, where we used both PowerPC and MicroBlaze cores, http, Java, and LabView for control and communication, together with the MicroC/OS-II and OSE operating systems

  16. Actuator Characterization of Man Portable Precision Maneuver Concepts

    DTIC Science & Technology

    2014-03-01

    brushless DC motors, along with a model of the rotating wing concept and a prototype 40-mm projectile, which was fired through the spark range (14), is... Brushless Electronic Speed Controller) was used to drive the three motor commutator input lines. This controller inputs a pulse-width modulated (PWM...Part II: The Brushless D.C. Motor Drive. IEEE Transactions on Industry Applications 1989, 25 (2), 274–279. 16. Hemati, N.; Leu, M. A Complete

  17. Hospital reimbursement incentives: is there a more effective option?--Part II.

    PubMed

    Weil, Thomas P

    2013-01-01

    As discussed in Part I of this article, hospital executives in Canada, Germany, and the United States manage their facilities' resources to maximize the incentives inherent in their respective reimbursement system and thereby increase their bottom line. It was also discussed that an additional supply of available hospitals, physicians, and other services will generate increased utilization. Part II discusses how the Patient Protection and Affordable Care Act of 2010 will eventually fail since it neither controls prices nor utilization (e.g., imaging, procedures, ambulatory surgery, discretionary spending). This article concludes with the discussion of the German multipayer approach with universal access and global budgets that might well be a model for U.S. healthcare in the future. Although the German healthcare system has a number of shortfalls, its paradigm could offer the most appropriate compromise when selecting the economic incentives to reduce the percentage of the U.S. gross domestic product expenditure for healthcare from 17.4% to roughly 12.0%.

  18. Design verification and fabrication of active control systems for the DAST ARW-2 high aspect ratio wing. Part 2: Appendices

    NASA Technical Reports Server (NTRS)

    Mcgehee, C. R.

    1986-01-01

    This is Part 2-Appendices of a study conducted under Drones for Aerodynamic and Structural Testing (DAST) Program to accomplish the final design and hardware fabrication for four active control systems compatible with and ready for installation in the NASA Aeroelastic Research Wing No. 2 (ARW-2) and Firebee II drone flight test vehicle. The wing structure was designed so that Active Control Systems (ACS) are required in the normal flight envelope by integrating control system design with aerodynamics and structure technologies. The DAST ARW-2 configuration uses flutter suppression, relaxed static stability, and gust and maneuver load alleviation ACS systems, and an automatic flight control system. Performance goals and criteria were applied to individual systems and the systems collectively to assure that vehicle stability margins, flutter margins, flying qualities, and load reductions were achieved.

  19. Schwertmannite stability in anoxic Fe(II)-rich aqueous solution

    NASA Astrophysics Data System (ADS)

    Paikaray, Susanta; Schröder, Christian; Peiffer, Stefan

    2017-11-01

    Schwertmannite (SHM) is a powerful scavenger for As(III) leading to As(III)-enriched precipitates around acid mine drainage environments that may become exposed to aqueous Fe(II). In this study we have investigated the stability of pure SHM and SHM containing 0.92 wt% As(III) under Fe(II)aq-rich (0.4-1.0 mM) anoxic conditions using XRD, SEM, Mössbauer and FTIR spectroscopic techniques. Schwertmannite transformation proceeded through an alkalinity-driven pathway releasing sulfate and a Fe(II)-catalyzed pathway that generated lepidocrocite and goethite at pH 6 and 6.9 in the presence of 1 mM Fe(II)aq. Lepidocrocite was found to be needle shaped if the SHM contained As(III) and platy for pure SHM. Goethite had a poor degree of crystallinity in As(III) containing SHM. Pre-adsorption of As(III) inhibited the extent of SHM transformation. Fe(II) sorption onto SHM was pH dependent and reflected a sorption edge with complete consumption at pH 6.9, while only ∼20% were adsorbed at pH 5. Surface coverage with Fe(II) appears to be the key parameter controlling extent and products of the transformation process. As(III) concentrations in solution are controlled by two mechanisms: (1) exchange of As(III) for sulfate upon alkalinity-driven transformation of schwertmannite and (2) re-adsorption to new phases formed upon Fe(II)-catalyzed transformation. The adsorbed As(III) has inhibited the extent of transformation and was partly released with the maximum release at pH 5 (0.5%) in the absence of Fe(II)aq.

  20. EFFECTS OF BIOSOLIDS APPLICATION ON EROSION CONTROL AND ECOSYSTEM RECOVERY FOLLOWING THE BUFFALO CREEK FIRE - PART II

    EPA Science Inventory

    Nutrient (i.e. nitrogen) contamination of surface waters constitutes one of the most pervasive problems facing wastewater treatment works across the country. Nitrogen discharge to surface water occurs mostly in the form of ammonia which is identified as the most toxic nitrogen sp...

  1. 30 CFR 913.30 - State-Federal cooperative agreement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

  2. 30 CFR 913.30 - State-Federal cooperative agreement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

  3. 30 CFR 913.30 - State-Federal cooperative agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

  4. 30 CFR 913.30 - State-Federal cooperative agreement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

  5. 30 CFR 913.30 - State-Federal cooperative agreement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... seq., and implementing regulations, including 40 CFR part 1500. 4. The Endangered Species Act, as... section 523(c) of the Surface Mining Control and Reclamation Act (SMCRA), 30 U.S.C. 1273(c), which allows... administer this Agreement on behalf of the Secretary. Article II: Effective Date After being signed by the...

  6. Embryological Development: Evolutionary History, Genetic Bias, and Cellular Environment Control the Flow of Developmental Events, Part II.

    ERIC Educational Resources Information Center

    Caplan, Arnold I.

    1981-01-01

    Emphasizes ectodermal-mesodermal interaction but focuses on the genesis of specialized structures like feathers (ectodermal) and muscles, cartilage, and bone. The sum of these interactions and other factors which govern normal development may be important in regulating the regeneration of particular structures in postembryonic individuals.…

  7. Living with AIDS: Part II.

    ERIC Educational Resources Information Center

    Daedalus: Journal of the American Academy of Arts and Sciences, 1989

    1989-01-01

    A series of articles concerning various aspects of AIDS and the dilemmas it poses for U.S. society, culture, and government are presented, in this theme issue, e.g., "Introduction to the Issue" (K. Keniston); "Prospects for the Medical Control of the AIDS Epidemic" (W. Haseltine); "Social Policy: AIDS and Intravenous Drug Use" (N. Zinberg);…

  8. 7 CFR 800.199 - Conflict-of-interest provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and (ii) any board of trade, chamber of commerce, grain exchange, or other trade group composed, in... office space or inspection, weighing, transportation, or office equipment that is owned or controlled, in whole or in part, by a grain business or related entity when the use of the space or equipment is...

  9. 7 CFR 800.199 - Conflict-of-interest provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and (ii) any board of trade, chamber of commerce, grain exchange, or other trade group composed, in... office space or inspection, weighing, transportation, or office equipment that is owned or controlled, in whole or in part, by a grain business or related entity when the use of the space or equipment is...

  10. 7 CFR 800.199 - Conflict-of-interest provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and (ii) any board of trade, chamber of commerce, grain exchange, or other trade group composed, in... office space or inspection, weighing, transportation, or office equipment that is owned or controlled, in whole or in part, by a grain business or related entity when the use of the space or equipment is...

  11. 7 CFR 800.199 - Conflict-of-interest provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and (ii) any board of trade, chamber of commerce, grain exchange, or other trade group composed, in... office space or inspection, weighing, transportation, or office equipment that is owned or controlled, in whole or in part, by a grain business or related entity when the use of the space or equipment is...

  12. 28 CFR 16.76 - Exemption of Justice Management Division.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... civil law enforcement proceedings and impose an impossible administrative burden by requiring... maintained in this system are restricted by law. Section 3607(b) of Title 18 U.S.C. (enacted as part of the... persons with no prior conviction under a Federal or State law relating to controlled substances, or (ii...

  13. 28 CFR 16.76 - Exemption of Justice Management Division.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... civil law enforcement proceedings and impose an impossible administrative burden by requiring... maintained in this system are restricted by law. Section 3607(b) of Title 18 U.S.C. (enacted as part of the... persons with no prior conviction under a Federal or State law relating to controlled substances, or (ii...

  14. 28 CFR 16.76 - Exemption of Justice Management Division.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... civil law enforcement proceedings and impose an impossible administrative burden by requiring... maintained in this system are restricted by law. Section 3607(b) of Title 18 U.S.C. (enacted as part of the... persons with no prior conviction under a Federal or State law relating to controlled substances, or (ii...

  15. 28 CFR 16.76 - Exemption of Justice Management Division.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... civil law enforcement proceedings and impose an impossible administrative burden by requiring... maintained in this system are restricted by law. Section 3607(b) of Title 18 U.S.C. (enacted as part of the... persons with no prior conviction under a Federal or State law relating to controlled substances, or (ii...

  16. 28 CFR 16.76 - Exemption of Justice Management Division.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... civil law enforcement proceedings and impose an impossible administrative burden by requiring... maintained in this system are restricted by law. Section 3607(b) of Title 18 U.S.C. (enacted as part of the... persons with no prior conviction under a Federal or State law relating to controlled substances, or (ii...

  17. 21 CFR 1305.28 - Canceling and voiding electronic orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 9 2014-04-01 2014-04-01 false Canceling and voiding electronic orders. 1305.28... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.28 Canceling and voiding electronic orders. (a) A supplier may void all or part of an electronic order by notifying the purchaser of the voiding...

  18. 21 CFR 1305.28 - Canceling and voiding electronic orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Canceling and voiding electronic orders. 1305.28... I AND II CONTROLLED SUBSTANCES Electronic Orders § 1305.28 Canceling and voiding electronic orders. (a) A supplier may void all or part of an electronic order by notifying the purchaser of the voiding...

  19. Anaerobic Digestion II. Sludge Treatment and Disposal Course #166. Instructor's Guide [and] Student Workbook.

    ERIC Educational Resources Information Center

    Arasmith, E. E.

    This lesson is the second of a two-part series on anaerobic digestion. Topics discussed include classification of digester by function, roof design, and temperature range, mixing systems, gas system components, operational control basics, and general safety considerations. The lesson includes an instructor's guide and student workbook. The…

  20. 49 CFR 219.4 - Recognition of a foreign railroad's workplace testing program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE... contains equivalents to subparts B, E, F, and G of this part: (i) Pre-employment drug testing; (ii) A policy dealing with co-worker and self-reporting of alcohol and drug abuse problems; (iii) Random drug...

  1. 49 CFR 219.4 - Recognition of a foreign railroad's workplace testing program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE... contains equivalents to subparts B, E, F, and G of this part: (i) Pre-employment drug testing; (ii) A policy dealing with co-worker and self-reporting of alcohol and drug abuse problems; (iii) Random drug...

  2. 49 CFR 219.4 - Recognition of a foreign railroad's workplace testing program.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE... contains equivalents to subparts B, E, F, and G of this part: (i) Pre-employment drug testing; (ii) A policy dealing with co-worker and self-reporting of alcohol and drug abuse problems; (iii) Random drug...

  3. 49 CFR 219.4 - Recognition of a foreign railroad's workplace testing program.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE... contains equivalents to subparts B, E, F, and G of this part: (i) Pre-employment drug testing; (ii) A policy dealing with co-worker and self-reporting of alcohol and drug abuse problems; (iii) Random drug...

  4. Expression pattern of the pre-prothaumatin II gene under the control of the CaMV 35S promoter in transgenic cucumber (Cucumis sativus L.) flower buds and fruits.

    PubMed

    Szwacka, M; Siedlecka, E; Zawirska-Wojtasiak, R; Wiśniewski, Ł; Malepszy, S

    2009-01-01

    Thaumatin II is an extremely sweet-tasting protein produced by fruits of the West African shrub Thaumatococcus daniellii Benth, so it can be used in biotechnology to improve the tastes of various plant products. This study is concerned with the spatial and temporal aspects of expression of the 35S-pre-prothaumatin II chimeric gene in flower buds and fruits of transgenic cucumber (Cucumis sativus L.) line 225. The activity of the 35S promoter in organs of line 225 was compared with its activity in 2 other transgenic lines. The accumulation of recombinant thaumatin varied spatially in flower bud tissues of transgenic lines. We found that these differences in the spatial accumulation of transgenic protein concerned the ovary of female buds and the perianth of male buds. In contrast to flower parts, recombinant thaumatin was found in nearly all parts of the young fruit from the transgenic plants. The pre-prothaumatin II gene expression was detected at a very early developmental stage in male buds, and its pattern was rather conserved as the buds aged. The expression of the transgene was also detected in vascular tissues of examined organs but was undetectable in pollen grains, in agreement with the generally held view that the CaMV 35S promoter is virtually silent in pollen. Immunocytochemical analyses of sections of control organs revealed endogenous homolog(s) of thaumatin when using polyclonal antisera, but not when using monoclonal antibodies for recombinant thaumatin detection in transgenic cucumber.

  5. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases; Part 1: alkyl halide alkylations.

    PubMed

    Sorochinsky, Alexander E; Aceña, José Luis; Moriwaki, Hiroki; Sato, Tatsunori; Soloshonok, Vadim A

    2013-10-01

    Alkylations of chiral or achiral Ni(II) complexes of glycine Schiff bases constitute a landmark in the development of practical methodology for asymmetric synthesis of α-amino acids. Straightforward, easy preparation as well as high reactivity of these Ni(II) complexes render them ready available and inexpensive glycine equivalents for preparing a wide variety of α-amino acids, in particular on a relatively large scale. In the case of Ni(II) complexes containing benzylproline moiety as a chiral auxiliary, their alkylation proceeds with high thermodynamically controlled diastereoselectivity. Similar type of Ni(II) complexes derived from alanine can also be used for alkylation providing convenient access to quaternary, α,α-disubstituted α-amino acids. Achiral type of Ni(II) complexes can be prepared from picolinic acid or via recently developed modular approach using simple secondary or primary amines. These Ni(II) complexes can be easily mono/bis-alkylated under homogeneous or phase-transfer catalysis conditions. Origin of diastereo-/enantioselectivity in the alkylations reactions, aspects of practicality, generality and limitations of this methodology is critically discussed.

  6. Family Finance Education; An Interdisciplinary Approach. Volume II.

    ERIC Educational Resources Information Center

    Gibbs, Mary S., Ed.; And Others, Eds.

    Volume II of a two-part series related to family finance education provides materials for study and discussion in the 1968 workshop. In Part I, members of the advisory council present their viewpoints concerning an interdisciplinary approach to education in family finance. Part II presents basic and current information related to principal areas…

  7. New class of control laws for robotic manipulators. I - Nonadaptive case. II - Adaptive case

    NASA Technical Reports Server (NTRS)

    Wen, John T.; Bayard, David S.

    1988-01-01

    A new class of exponentially stabilizing control laws for joint level control of robot arms is discussed. Closed-loop exponential stability has been demonstrated for both the set point and tracking control problems by a slight modification of the energy Lyapunov function and the use of a lemma which handles third-order terms in the Lyapunov function derivatives. In the second part, these control laws are adapted in a simple fashion to achieve asymptotically stable adaptive control. The analysis addresses the nonlinear dynamics directly without approximation, linearization, or ad hoc assumptions, and uses a parameterization based on physical (time-invariant) quantities.

  8. The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation

    PubMed Central

    Carpenter, Andrea C.; Grainger, John R.; Xiong, Yumei; Kanno, Yuka; Chu, H. Hamlet; Wang, Lie; Naik, Shruti; dos Santos, Liliane; Wei, Lai; Jenkins, Marc K.; O’Shea, John J.; Belkaid, Yasmine; Bosselut, Rémy

    2014-01-01

    Summary T helper (Th) cells are critical for defenses against infection and recognize peptides bound to Class II Major Histocompatibility Complex (MHC-II) molecules. Although transcription factors have been identified that direct helper cells into specific effector fates, whether a ‘master’ regulator controls the developmental program common to all Th cells remains unclear. Here we showed that the two transcription factors Thpok and LRF share this function. Although disruption of both factors did not prevent the generation of MHC II-specific T cells, these cells failed to express Th cell genes or undergo Th cell differentiation in vivo. In contrast, T cells lacking Thpok only displayed LRF-dependent functions and contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extra-cellular parasites. These findings identify the Thpok-LRF pair as a core node of Th cell differentiation and function. PMID:23041065

  9. An Investigation of the Aerodynamic Characteristics of an 0.08-Scale Model of the Chance Vought XF7U-1 Airplane in the Langley High-Speed 7- by 10-Foot Tunnel. Part II - Basic Lateral Stability Characteristics TED No. NACA DE308. Part 2; Basic Lateral Stability Charactistics, TED No. NACA DE308

    NASA Technical Reports Server (NTRS)

    Kemp, William B., Jr.; Goodson, Kenneth W.; Kuhn, Richard E.

    1947-01-01

    Tests have been conducted in the Langley high-speed 7- by 10-foot tunnel over a Mach number range from 0.40 to 0.91 to determine the stability and control characteristics of an 0.08-scale model of the Chance Vought XF7U-1 airplane. The basic lateral stability characteristics of the complete model with undeflected control surfaces are presented in the present report with a very limited analysis of the results.

  10. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II

    PubMed Central

    Sverdlov, Aaron L.; Elezaby, Aly; Behring, Jessica B.; Bachschmid, Markus M.; Luptak, Ivan; Tu, Vivian H.; Siwik, Deborah A.; Miller, Edward J.; Liesa, Marc; Shirihai, Orian S; Pimentel, David R.; Cohen, Richard A.; Colucci, Wilson S.

    2014-01-01

    Background Diet-induced obesity leads to metabolic heart disease (MHD) characterized by increased oxidative stress that may cause oxidative post-translational modifications (OPTM) of cardiac mitochondrial proteins. The functional consequences of OPTM of cardiac mitochondrial proteins in MHD are unknown. Our objective was to determine whether cardiac mitochondrial dysfunction in MHD due to diet-induced obesity is associated with cysteine OPTM. Methods and results Male C57Bl/6J mice were fed either a high-fat, high-sucrose (HFHS) or control diet for 8 months. Cardiac mitochondria from HFHS-fed mice (vs. control diet) had an increased rate of H2O2 production, a decreased GSH/GSSG ratio, a decreased rate of complex II substrate-driven ATP synthesis and decreased complex II activity. Complex II substrate-driven ATP synthesis and complex II activity were partially restored ex-vivo by reducing conditions. A biotin switch assay showed that HFHS feeding increased cysteine OPTM in complex II subunits A (SDHA) and B (SDHB). Using iodo-TMT multiplex tags we found that HFHS feeding is associated with reversible oxidation of cysteines 89 and 231 in SDHA, and 100, 103 and 115 in SDHB. Conclusions MHD due to consumption of a HFHS “Western” diet causes increased H2O2 production and oxidative stress in cardiac mitochondria associated with decreased ATP synthesis and decreased complex II activity. Impaired complex II activity and ATP production are associated with reversible cysteine OPTM of complex II. Possible sites of reversible cysteine OPTM in SDHA and SDHB were identified by iodo-TMT tag labeling. Mitochondrial ROS may contribute to the pathophysiology of MHD by impairing the function of complex II. PMID:25109264

  11. 10 CFR Appendix II to Part 960 - NRC and EPA Requirements for Preclosure Repository Performance

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false NRC and EPA Requirements for Preclosure Repository... SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Pt. 960, App. II Appendix II to Part 960—NRC and EPA Requirements for Preclosure Repository Performance Under proposed 40 CFR part 191, subpart A...

  12. A Dynamic Model of the Initial Spares Support List Development Process

    DTIC Science & Technology

    1979-06-01

    S117Z1NOTE NREI -NOT READI END ITERS IIT7INOTE GPEI -QUANTITY OF PARTS M. END ITER 11775NOTE FUSERF -PARTS USE RATE FACTOR U8WOTE OP U -OTHER PARTS USE...FAILURES ’I 1675R PtJER.L=(NREI.K) (QPEI) (PUSERF.K)+OPUR II7HNOTE PUSER -PARTS USE RATE II7t5NOTE NREI -NOT READY END ITEMS II756NOTE GPEI -QUANTITY

  13. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .../cm2. ......do kPa 1×10 3 N/m 2. Temperature Degree Celsius °C 5/9 (°F-32). Viscosity milli-Pascal... 46 Shipping 5 2013-10-01 2013-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153... common metric Force Newton N 0.225 lbs. Length Meter m 39.37 in. Centimeter cm .3937 in. Pressure Pascal...

  14. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .../cm2. ......do kPa 1×10 3 N/m 2. Temperature Degree Celsius °C 5/9 (°F-32). Viscosity milli-Pascal... 46 Shipping 5 2012-10-01 2012-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153... common metric Force Newton N 0.225 lbs. Length Meter m 39.37 in. Centimeter cm .3937 in. Pressure Pascal...

  15. 46 CFR Appendix II to Part 153 - Metric Units Used in Part 153

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .../cm2. ......do kPa 1×10 3 N/m 2. Temperature Degree Celsius °C 5/9 (°F-32). Viscosity milli-Pascal... 46 Shipping 5 2014-10-01 2014-10-01 false Metric Units Used in Part 153 II Appendix II to Part 153... common metric Force Newton N 0.225 lbs. Length Meter m 39.37 in. Centimeter cm .3937 in. Pressure Pascal...

  16. Program Manager: Journal of the Defense Systems Management College, Volume 22, Number 6, November - December 1993

    DTIC Science & Technology

    1993-12-01

    in the busi - ness...."- Congressional intervention in rebuilding the Navy was undenvay and would increase in magnitude and frequency. Construction...and tie OC- pr11OVcd cha racicriSt ics iii to corn pcItcd ti"c11mC. huLt tIic cra, of ilntcHrnat ioiia cUII pai thicrcafter shiarcd ii uclIi of tile...and heavy equipment. ferred for years: the use of liquid fuel as a part-time coal substitute. Much of the Navy’s business was controlled by brokers

  17. 78 FR 9057 - Medicare Program; Request for Information on the Use of Clinical Quality Measures (CQMs) Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ... Part II: Lifelong Learning and Self-Assessment Part III: Cognitive Expertise Part IV: Practice...: Licensure and Professional Standing Part II: Lifelong Learning and Self-Assessment Part III: Cognitive...\\ The MOC assesses physicians' commitment to lifelong learning according to the following six core...

  18. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

  19. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

  20. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

  1. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Temperature Schedules II Appendix II... Appendix II to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

  2. Mineral scale management. Part II, Fundamental chemistry

    Treesearch

    Alan W. Rudie; Peter W. Hart

    2006-01-01

    The mineral scale that deposits in digesters and bleach plants is formed by a chemical precipitation process.As such, it is accurately modeled using the solubility product equilibrium constant. Although solubility product identifies the primary conditions that must be met for a scale problem to exist, the acid-base equilibria of the scaling anions often control where...

  3. Particulate Matter Stack Emission Compliance Test Procedure for Fuel Burning Units.

    ERIC Educational Resources Information Center

    West Virginia Air Pollution Control Commission, Charleston.

    This publication details the particulate matter emissions test procedure that is applicable for conducting compliance tests for fuel burning units required to be tested under Sub-section 7 of Regulation II (1972) as established by the state of West Virginia Air Pollution Control Commission. The testing procedure is divided into five parts:…

  4. The Nature of Indexing: How Humans and Machines Analyze Messages and Texts for Retrieval. Part II: Machine Indexing, and the Allocation of Human versus Machine Effort.

    ERIC Educational Resources Information Center

    Anderson, James D.; Perez-Carballo, Jose

    2001-01-01

    Discussion of human intellectual indexing versus automatic indexing focuses on automatic indexing. Topics include keyword indexing; negative vocabulary control; counting words; comparative counting and weighting; stemming; words versus phrases; clustering; latent semantic indexing; citation indexes; bibliographic coupling; co-citation; relevance…

  5. 10 CFR 707.11 - Drugs for which testing is performed.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Drugs for which testing is performed. 707.11 Section 707... Drugs for which testing is performed. Where testing is performed under this part, at a minimum... occurrence testing, the contractor may test for any drug listed in Schedules I or II of the Controlled...

  6. 10 CFR 707.11 - Drugs for which testing is performed.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Drugs for which testing is performed. 707.11 Section 707... Drugs for which testing is performed. Where testing is performed under this part, at a minimum... occurrence testing, the contractor may test for any drug listed in Schedules I or II of the Controlled...

  7. 10 CFR 707.11 - Drugs for which testing is performed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Drugs for which testing is performed. 707.11 Section 707... Drugs for which testing is performed. Where testing is performed under this part, at a minimum... occurrence testing, the contractor may test for any drug listed in Schedules I or II of the Controlled...

  8. 10 CFR 707.11 - Drugs for which testing is performed.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Drugs for which testing is performed. 707.11 Section 707... Drugs for which testing is performed. Where testing is performed under this part, at a minimum... occurrence testing, the contractor may test for any drug listed in Schedules I or II of the Controlled...

  9. 10 CFR 707.11 - Drugs for which testing is performed.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Drugs for which testing is performed. 707.11 Section 707... Drugs for which testing is performed. Where testing is performed under this part, at a minimum... occurrence testing, the contractor may test for any drug listed in Schedules I or II of the Controlled...

  10. AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT X, AUTOMATIC TRANSMISSIONS--HYDRAULIC SYSTEMS (PART II).

    ERIC Educational Resources Information Center

    Human Engineering Inst., Cleveland, OH.

    THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO PROVIDE A SUMMARY OF MAINTENANCE PROCEDURES FOR AUTOMATIC TRANSMISSIONS USED ON DIESEL POWERED VEHICLES. TOPICS ARE (1) CHECKING THE HYDRAULIC SYSTEM, (2) SERVICING THE HYDRAULIC SYSTEM, (3) EXAMINING THE RANGE CONTROL VALVE, (4) EXAMINING THE LOCK-UP AND FLOW VALVE, (5) EXAMINING THE MAIN REGULATOR…

  11. 40 CFR 96.71 - Initial certification and recertification procedures

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: replacement of the analyzer, change in location or orientation of the sampling probe or site, or changing of... basis under § 96.74(d); (i) For a unit that has commences operation before its compliance deadline under... control period basis under § 96.74(b)(3)(ii) of this part: (i) For a unit that commenced operation before...

  12. 17 CFR 405.2 - Reports to be made by registered government securities brokers and dealers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... government securities broker or dealer shall file Part I of Form BD-Y2K (§ 249.618 of this title) prepared as..., shall file Part II of Form BD-Y2K (§ 249.618 of this title). Part II of Form BD-Y2K shall address each... registered government securities broker or dealer that was not required to file Part II of Form BD-Y2K under...

  13. Basic Services for Children: A Continuing Search for Learning Priorities. A Dossier for Initiating a Dialogue--Part II, 1978. Experiments and Innovations in Education No. 37.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    Both parts I and II of the dossier are collections of selected activities directed toward the deprived young in a developing world. This book, part II, departs from its predecessor in that it takes a more global view of education services to both children and adults in developing countries. Part A discusses the philosophy and scope of the dossier.…

  14. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  15. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  16. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  17. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  18. 40 CFR Appendix III to Part 266 - Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride III Appendix III to Part 266 Protection of Environment... to Part 266—Tier II Emission Rate Screening Limits for Free Chlorine and Hydrogen Chloride Terrain...

  19. NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways.

    PubMed

    Zhao, Qingwei David; Viswanadhapalli, Suryavathi; Williams, Paul; Shi, Qian; Tan, Chunyan; Yi, Xiaolan; Bhandari, Basant; Abboud, Hanna E

    2015-02-17

    NADPH oxidase 4 (Nox4) has been implicated in cardiac remodeling, but its precise role in cardiac injury remains controversial. Furthermore, little is known about the downstream effector signaling pathways activated by Nox4-derived reactive oxygen species in the myocardium. We investigated the role of Nox4 and Nox4-associated signaling pathways in the development of cardiac remodeling. Cardiac-specific human Nox4 transgenic mice (c-hNox4Tg) were generated. Four groups of mice were studied: (1) control mice, littermates that are negative for hNox4 transgene but Cre positive; (2) c-hNox4 Tg mice; (3) angiotensin II (AngII)-infused control mice; and (4) c-hNox4Tg mice infused with AngII. The c-hNox4Tg mice exhibited an ≈10-fold increase in Nox4 protein expression and an 8-fold increase in the production of reactive oxygen species, and manifested cardiac interstitial fibrosis. AngII infusion to control mice increased cardiac Nox4 expression and induced fibrosis and hypertrophy. The Tg mice receiving AngII exhibited more advanced cardiac remodeling and robust elevation in Nox4 expression, indicating that AngII worsens cardiac injury, at least in part by enhancing Nox4 expression. Moreover, hNox4 transgene and AngII infusion induced the expression of cardiac fetal genes and activated the Akt-mTOR and NFκB signaling pathways. Treatment of AngII-infused c-hNox4Tg mice with GKT137831, a Nox4/Nox1 inhibitor, abolished the increase in oxidative stress, suppressed the Akt-mTOR and NFκB signaling pathways, and attenuated cardiac remodeling. Upregulation of Nox4 in the myocardium causes cardiac remodeling through activating Akt-mTOR and NFκB signaling pathways. Inhibition of Nox4 has therapeutic potential to treat cardiac remodeling. © 2015 American Heart Association, Inc.

  20. 40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Laboratory Testing II.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld engines with the following steady-state duty cycle: G3 mode No. Engine speed a Torque(percent) b Weighting...

  1. Bonding thermoplastic polymers

    DOEpatents

    Wallow, Thomas I [Fremont, CA; Hunter, Marion C [Livermore, CA; Krafcik, Karen Lee [Livermore, CA; Morales, Alfredo M [Livermore, CA; Simmons, Blake A [San Francisco, CA; Domeier, Linda A [Danville, CA

    2008-06-24

    We demonstrate a new method for joining patterned thermoplastic parts into layered structures. The method takes advantage of case-II permeant diffusion to generate dimensionally controlled, activated bonding layers at the surfaces being joined. It is capable of producing bonds characterized by cohesive failure while preserving the fidelity of patterned features in the bonding surfaces. This approach is uniquely suited to production of microfluidic multilayer structures, as it allows the bond-forming interface between plastic parts to be precisely manipulated at micrometer length scales. The bond enhancing procedure is easily integrated in standard process flows and requires no specialized equipment.

  2. Subseabed disposal program annual report, January-December 1980. Volume II. Appendices (principal investigator progress reports). Part 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hinga, K.R.

    Volume II of the sixth annual report describing the progress and evaluating the status of the Subseabed Disposal Program contains the appendices referred to in Volume I, Summary and Status. Because of the length of Volume II, it has been split into two parts for publication purposes. Part 1 contains Appendices A-Q; Part 2 contains Appendices R-MM. Separate abstracts have been prepared for each appendix for inclusion in the Energy Data Base.

  3. Toxic effect of metal cation binary mixtures to the seaweed Gracilaria domingensis (Gracilariales, Rhodophyta).

    PubMed

    Mendes, Luiz Fernando; Stevani, Cassius Vinicius; Zambotti-Villela, Leonardo; Yokoya, Nair Sumie; Colepicolo, Pio

    2014-01-01

    The macroalga Gracilaria domingensis is an important resource for the food, pharmaceutical, cosmetic, and biotechnology industries. G. domingensis is at a part of the food web foundation, providing nutrients and microelements to upper levels. As seaweed storage metals in the vacuoles, they are considered the main vectors to magnify these toxic elements. This work describes the evaluation of the toxicity of binary mixtures of available metal cations based on the growth rates of G. domingensis over a 48-h exposure. The interactive effects of each binary mixture were determined using a toxic unit (TU) concept that was the sum of the relative contribution of each toxicant and calculated using the ratio between the toxicant concentration and its endpoint. Mixtures of Cd(II)/Cu(II) and Zn(II)/Ca(II) demonstrated to be additive; Cu(II)/Zn(II), Cu(II)/Mg(II), Cu(II)/Ca(II), Zn(II)/Mg(II), and Ca(II)/Mg(II) mixtures were synergistic, and all interactions studied with Cd(II) were antagonistic. Hypotheses that explain the toxicity of binary mixtures at the molecular level are also suggested. These results represent the first effort to characterize the combined effect of available metal cations, based on the TU concept on seaweed in a total controlled medium. The results presented here are invaluable to the understanding of seaweed metal cation toxicity in the marine environment, the mechanism of toxicity action and how the tolerance of the organism.

  4. Tailless Vectored Fighters Theory. Laboratory and Flight Tests, Including Vectorable Inlets/Nozzles and Tailless Flying Models vs. Pilot’s Tolerances Affecting Maximum Post-Stall Vectoring Agility.

    DTIC Science & Technology

    1991-07-01

    nose bodyj Top view of velocity probe PropllerRotating shaft ’V Generator Aerodynamic shape like a small elevator RPV’s attitude Irrespctiveduring...28 Part It: Maximizing Thrust-Vectoring Control Power and Agility Metrics ............ 29 Laboratory & Flight...8217Ideal Standards’ - Ba- ror maximizing PST-TV-aglilty/rIlght-control power , iI - Extracting new TV-potentials to further reduce any righter’s optical

  5. Design and Implementation of Hybrid CORDIC Algorithm Based on Phase Rotation Estimation for NCO

    PubMed Central

    Zhang, Chaozhu; Han, Jinan; Li, Ke

    2014-01-01

    The numerical controlled oscillator has wide application in radar, digital receiver, and software radio system. Firstly, this paper introduces the traditional CORDIC algorithm. Then in order to improve computing speed and save resources, this paper proposes a kind of hybrid CORDIC algorithm based on phase rotation estimation applied in numerical controlled oscillator (NCO). Through estimating the direction of part phase rotation, the algorithm reduces part phase rotation and add-subtract unit, so that it decreases delay. Furthermore, the paper simulates and implements the numerical controlled oscillator by Quartus II software and Modelsim software. Finally, simulation results indicate that the improvement over traditional CORDIC algorithm is achieved in terms of ease of computation, resource utilization, and computing speed/delay while maintaining the precision. It is suitable for high speed and precision digital modulation and demodulation. PMID:25110750

  6. Fourth - generation languages. Volume 2. Representative 4GLs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Martin, J.

    1986-01-01

    The chapters in Part II each describe one representative product marketed by a vendor other than IBM. (Volume III of this work covers IBM languages.) The chapters in Part II cover the following 4GLs: ADS/ONLINE, APPLICATION FACTORY, DATATRIEVE, FOCUS, IDEAL, INTELLECT, MANTIS, MIMER, NATURAL, NOMAD2, RAMIS II, SYSTEM W, and USE-IT. The Perspective section of Part II presents a general overview of the product and describes its role in the marketplace. The Tutorial section describes how a user employs the language in application development.

  7. Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial.

    PubMed

    Nations, Kari R; Dogterom, Peter; Bursi, Roberta; Schipper, Jacques; Greenwald, Scott; Zraket, David; Gertsik, Lev; Johnstone, Jack; Lee, Allen; Pande, Yogesh; Ruigt, Ge; Ereshefsky, Larry

    2012-12-01

    Org 26576 acts by modulating ionotropic AMPA-type glutamate receptors to enhance glutamatergic neurotransmission. The aim of this Phase 1b study (N=54) was to explore safety, tolerability, pharmacokinetics, and pharmacodynamics of Org 26576 in depressed patients. Part I (N=24) evaluated the maximum tolerated dose (MTD) and optimal titration schedule in a multiple rising dose paradigm (range 100 mg BID to 600 mg BID); Part II (N=30) utilized a parallel groups design (100 mg BID, 400 mg BID, placebo) to examine all endpoints over a 28-day dosing period. Based on the number of moderate intensity adverse events reported at the 600 mg BID dose level, the MTD established in Part I was 450 mg BID. Symptomatic improvement as measured by the Montgomery-Asberg Depression Rating Scale was numerically greater in the Org 26576 groups than in the placebo group in both study parts. In Part II, the 400 mg BID dose was associated with improvements in executive functioning and speed of processing cognitive tests. Org 26576 was also associated with growth hormone increases and cortisol decreases at the end of treatment but did not influence prolactin or brain-derived neurotrophic factor. The quantitative electroencephalogram index Antidepressant Treatment Response at Week 1 was able to significantly predict symptomatic response at endpoint in the active treatment group, as was early improvement in social acuity. Overall, Org 26576 demonstrated good tolerability and pharmacokinetic properties in depressed patients, and pharmacodynamic endpoints suggested that it may show promise in future well-controlled, adequately powered proof of concept trials.

  8. 40 CFR Appendix II to Part 1042 - Steady-State Duty Cycles

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Steady-State Duty Cycles II Appendix..., App. II Appendix II to Part 1042—Steady-State Duty Cycles (a) The following duty cycles apply as specified in § 1042.505(b)(1): (1) The following duty cycle applies for discrete-mode testing: E3 mode No...

  9. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

  10. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

  11. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a b c Grams/liter coating (minus water and...

  12. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

  13. 40 CFR Table 2 to Subpart II of... - Volatile Organic HAP (VOHAP) Limits for Marine Coatings

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for Marine Coatings 2 Table 2 to Subpart II of Part 63 Protection of Environment ENVIRONMENTAL... (Surface Coating) Pt. 63, Subpt. II, Table 2 Table 2 to Subpart II of Part 63—Volatile Organic HAP (VOHAP) Limits for Marine Coatings Coating category VOHAP limits a,b,c Grams/liter coating (minus water and...

  14. Haptic control of a pneumatic muscle actuator to provide resistance for simulated isokinetic exercise; part II: control development and testing.

    PubMed

    Hall, Kara L; Phillips, Chandler A; Reynolds, David B; Mohler, Stanley R; Rogers, Dana B; Neidhard-Doll, Amy T

    2015-01-01

    Pneumatic muscle actuators (PMAs) have a high power to weight ratio and possess unique characteristics which make them ideal actuators for applications involving human interaction. PMAs are difficult to control due to nonlinear dynamics, presenting challenges in system implementation. Despite these challenges, PMAs have great potential as a source of resistance for strength training and rehabilitation. The objective of this work was to control a PMA for use in isokinetic exercise, potentially benefiting anyone in need of optimal strength training through a joint's range of motion. The controller, based on an inverse three-element phenomenological model and adaptive nonlinear control, allows the system to operate as a type of haptic device. A human quadriceps dynamic simulator was developed (as described in Part I of this work) so that control effectiveness and accommodation could be tested prior to human implementation. Tracking error results indicate that the control system is effective at producing PMA displacement and resistance necessary for a scaled, simulated neuromuscular actuator to maintain low-velocity isokinetic movement during simulated concentric and eccentric knee extension.

  15. Optimal starting conditions for the rendezvous maneuver: Analytical and computational approach

    NASA Astrophysics Data System (ADS)

    Ciarcia, Marco

    The three-dimensional rendezvous between two spacecraft is considered: a target spacecraft on a circular orbit around the Earth and a chaser spacecraft initially on some elliptical orbit yet to be determined. The chaser spacecraft has variable mass, limited thrust, and its trajectory is governed by three controls, one determining the thrust magnitude and two determining the thrust direction. We seek the time history of the controls in such a way that the propellant mass required to execute the rendezvous maneuver is minimized. Two cases are considered: (i) time-to-rendezvous free and (ii) time-to-rendezvous given, respectively equivalent to (i) free angular travel and (ii) fixed angular travel for the target spacecraft. The above problem has been studied by several authors under the assumption that the initial separation coordinates and the initial separation velocities are given, hence known initial conditions for the chaser spacecraft. In this paper, it is assumed that both the initial separation coordinates and initial separation velocities are free except for the requirement that the initial chaser-to-target distance is given so as to prevent the occurrence of trivial solutions. Two approaches are employed: optimal control formulation (Part A) and mathematical programming formulation (Part B). In Part A, analyses are performed with the multiple-subarc sequential gradient-restoration algorithm for optimal control problems. They show that the fuel-optimal trajectory is zero-bang, namely it is characterized by two subarcs: a long coasting zero-thrust subarc followed by a short powered max-thrust braking subarc. While the thrust direction of the powered subarc is continuously variable for the optimal trajectory, its replacement with a constant (yet optimized) thrust direction produces a very efficient guidance trajectory. Indeed, for all values of the initial distance, the fuel required by the guidance trajectory is within less than one percent of the fuel required by the optimal trajectory. For the guidance trajectory, because of the replacement of the variable thrust direction of the powered subarc with a constant thrust direction, the optimal control problem degenerates into a mathematical programming problem with a relatively small number of degrees of freedom, more precisely: three for case (i) time-to-rendezvous free and two for case (ii) time-to-rendezvous given. In particular, we consider the rendezvous between the Space Shuttle (chaser) and the International Space Station (target). Once a given initial distance SS-to-ISS is preselected, the present work supplies not only the best initial conditions for the rendezvous trajectory, but simultaneously the corresponding final conditions for the ascent trajectory. In Part B, an analytical solution of the Clohessy-Wiltshire equations is presented (i) neglecting the change of the spacecraft mass due to the fuel consumption and (ii) and assuming that the thrust is finite, that is, the trajectory includes powered subarcs flown with max thrust and coasting subarc flown with zero thrust. Then, employing the found analytical solution, we study the rendezvous problem under the assumption that the initial separation coordinates and initial separation velocities are free except for the requirement that the initial chaser-to-target distance is given. The main contribution of Part B is the development of analytical solutions for the powered subarcs, an important extension of the analytical solutions already available for the coasting subarcs. One consequence is that the entire optimal trajectory can be described analytically. Another consequence is that the optimal control problems degenerate into mathematical programming problems. A further consequence is that, vis-a-vis the optimal control formulation, the mathematical programming formulation reduces the CPU time by a factor of order 1000. Key words. Space trajectories, rendezvous, optimization, guidance, optimal control, calculus of variations, Mayer problems, Bolza problems, transformation techniques, multiple-subarc sequential gradient-restoration algorithm.

  16. Correlation of nitric oxide and other free radicals with the severity of acute pancreatitis and complicated systemic inflammatory response syndrome.

    PubMed

    Que, Ri-sheng; Cao, Li-ping; Ding, Guo-ping; Hu, Jun-an; Mao, Ke-jie; Wang, Gui-feng

    2010-05-01

    To investigate the correlation of nitric oxide (NO) and other free radicals with the severity of acute pancreatitis (AP) and complicated systemic inflammatory response syndrome (SIRS). Fifty AP patients (24 simple AP patients and 26 patients with AP complicated by SIRS) were involved in the study. Fifty healthy volunteers were included as controls. Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were evaluated, and plasma NO, plasma lipid peroxides, plasma vitamin E, plasma beta-carotene, whole-blood glutathione (GSH), and the activity of plasma GSH peroxidase were measured. Compared with the control group, the APACHE II scores heightened in the AP group, and the SIRS group had the highest APACHE II scores (P < 0.005, P < 0.001, respectively). Plasma NO and plasma lipid peroxides increased with the heightening APACHE II scores, demonstrating a significant linear positive correlation (r = 0.618, r = 0.577, respectively; P < 0.001). Plasma vitamin E, plasma beta-carotene, whole-blood GSH, and the activity of plasma GSH peroxidase decreased with the heightening APACHE II scores, demonstrating a significant linear negative correlation (r = -0.600, r = -0.609, r = -0.559, r = -0.592, respectively; P < 0.001). Nitric oxide and other free radicals take part in the aggravation of oxidative stress and oxidative injury and may play important roles in the pathogenesis of AP and SIRS. It may be valuable to measure free radicals to predict the severity of AP.

  17. 2013 Annual Site Inspection and Monitoring Report for Uranium Mill Tailings Radiation Control Act Title II Disposal Sites

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    This report, in fulfillment of a license requirement, presents the results of long-term surveillance and maintenance activities conducted by the U.S. Department of Energy (DOE) Office of Legacy Management in 2013 at six uranium mill tailings disposal sites reclaimed under Title II of the Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978. These activities verified that the UMTRCA Title II disposal sites remain in compliance with license requirements. DOE manages six UMTRCA Title II disposal sites under a general license granted by the U.S. Nuclear Regulatory Commission (NRC) established at Title 10 Code of Federal Regulations Part 40.28. Reclamationmore » and site transition activities continue at other sites, and DOE ultimately expects to manage approximately 27 Title II disposal sites. Long-term surveillance and maintenance activities and services for these disposal sites include inspecting and maintaining the sites; monitoring environmental media and institutional controls; conducting any necessary corrective action; and performing administrative, records, stakeholder services, and other regulatory functions. Annual site inspections and monitoring are conducted in accordance with site-specific long-term surveillance plans (LTSPs) and procedures established by DOE to comply with license requirements. Each site inspection is performed to verify the integrity of visible features at the site; to identify changes or new conditions that may affect the long-term performance of the site; and to determine the need, if any, for maintenance, follow-up inspections, or corrective action. LTSPs and site compliance reports are available online at http://www.lm.doe.gov« less

  18. 31 CFR Appendix II to Part 13 - Form of Bill for Reimbursement

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... title) of ______ (Country) to participate in the work of ______ (International Organization) or occurring at the _______ (Permanent or observer mission) to ______ (International organization) during the.... II Appendix II to Part 13—Form of Bill for Reimbursement I hereby request that ______ (Governmental...

  19. Eye Movement Control during Reading: II. Frequency of Refixating a Word. Technical Report No. 469.

    ERIC Educational Resources Information Center

    McConkie, G. W.; And Others

    As part of a series of studies describing the oculomotor behavior of skilled readers, a study investigated whether a word refixation curve exists. Subjects, 66 college students fixating over 40,000 times, read lines of text from a computer screen and were instructed to read for meaning without regard to errors. Results of eye movement control…

  20. Production of Butanol (a Biofuel) from Agricultural Residues: Part II - Use of Corn Stover and Switchgrass Hydrolysates

    USDA-ARS?s Scientific Manuscript database

    Acetone butanol ethanol (ABE or AB, or solvent) was produced from hydrolyzed corn stover and switchgrass using Clostridium beijerinckii P260. A control experiment using glucose resulted in the production of 21.06 gL**-1 total ABE. In this experiment, an AB yield and productivity of 0.41 and 0.31 g...

  1. Can Animations Effectively Substitute for Traditional Teaching Methods? Part II: Potential for Differentiated Learning

    ERIC Educational Resources Information Center

    Gregorius, Roberto Ma.; Santos, Rhodora; Dano, Judith B.; Gutierrez, Jose J.

    2010-01-01

    Animations were prepared using Adobe Flash MX and tested on elementary (3rd-5th grade) and secondary chemistry students. A pre- and post-test study was used to compare the learning gains of students who received the animations with those who received textbook reading time and discussion in class. The control and experimental groups were further…

  2. 21 CFR 1305.19 - Cancellation and voiding of DEA Forms 222.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Cancellation and voiding of DEA Forms 222. 1305.19... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.19 Cancellation and voiding of DEA Forms 222. (a) A purchaser may cancel part or all of an order on a DEA Form 222 by notifying the supplier in...

  3. 21 CFR 1305.14 - Procedure for endorsing DEA Forms 222.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false Procedure for endorsing DEA Forms 222. 1305.14... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.14 Procedure for endorsing DEA Forms 222. (a) A DEA Form 222, made out to any supplier who cannot fill all or a part of the order within the time...

  4. 21 CFR 1305.19 - Cancellation and voiding of DEA Forms 222.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Cancellation and voiding of DEA Forms 222. 1305.19... I AND II CONTROLLED SUBSTANCES DEA Form 222 § 1305.19 Cancellation and voiding of DEA Forms 222. (a) A purchaser may cancel part or all of an order on a DEA Form 222 by notifying the supplier in...

  5. Association Between National Board Dental Examination Part II Scores and Comprehensive Examinations at Harvard School of Dental Medicine.

    PubMed

    Lee, Min Kyeong; Allareddy, Veerasathpurush; Howell, T Howard; Karimbux, Nadeem Y

    2011-01-01

    Harvard School of Dental Medicine (HSDM) uses a hybrid problem-based approach to teaching in the predoctoral program. The objective structured clinical examination (OSCE) is a formative examination designed to assess the performance of students in the problem-based learning (PBL) curriculum. At HSDM three comprehensive examinations with OSCE components are administered during the third and fourth years of clinical training. The National Board Dental Examination (NBDE) Part II is taken in the final year of the predoctoral program. This study examines the association between the NBDE Part II and the comprehensive exams held at HSDM. Predoctoral students from the HSDM classes of 2005 and 2006 were included in this study. The outcome variable of interest was the scores obtained by students in the NBDE Part II, and the main independent variable of interest was the performance of students in the comprehensive exams (honors, pass, make-up exam to pass). The Mann-Whitney U-test was used to examine the association between the grades obtained in the each of the three comprehensive exams and the NBDE Part II scores. Multivariable linear regression analysis was also used to examine the association between the NBDE Part II scores and the comprehensive exam grades. The effect of potential confounding factors including age, sex, and race/ethnicity was adjusted. The results suggest that students who performed well in the comprehensive exams performed better on the NBDE Part II, even after adjusting for confounding factors. Future studies will examine the long-term impact of PBL on postdoctoral plans and career choices.

  6. Production-perception relationships during speech development

    NASA Astrophysics Data System (ADS)

    Menard, Lucie; Schwartz, Jean-Luc; Boe, Louis-Jean; Aubin, Jerome

    2005-04-01

    It has been shown that nonuniform growth of the supraglottal cavities, motor control development, and perceptual refinement shape the vowel systems during speech development. In this talk, we propose to investigate the role of perceptual constraints as a guide to the speakers task from birth to adulthood. Simulations with an articulatory-to-acoustic model, acoustic analyses of natural vowels, and results of perceptual tests provide evidence that the production-perception relationships evolve with age. At the perceptual level, results show that (i) linear combination of spectral peaks are good predictors of vowel targets, and (ii) focalization, defined as an acoustic pattern with close neighboring formants [J.-L. Schwartz, L.-J. Boe, N. Vallee, and C. Abry, J. Phonetics 25, 255-286 (1997)], is part of the speech task. At the production level, we propose that (i) frequently produced vowels in the baby's early sound inventory can in part be explained by perceptual templates, (ii) the achievement of these perceptual templates may require adaptive articulatory strategies for the child, compared with the adults, to cope with morphological differences. Results are discussed in the light of a perception for action control theory. [Work supported by the Social Sciences and Humanities Research Council of Canada.

  7. Exogenous bFGF or TGFβ1 accelerates healing of reconstructed dura by CO2 laser soldering in minipigs.

    PubMed

    Wang, Zhenmin; Zhong, Hongliang; Yang, Zhijun; Zhao, Fu; Wang, Bo; Qu, Peiran; Liu, Pinan

    2014-05-01

    This study aims to explore the probable mechanism of better result of dural reconstruction by CO2 laser soldering and the effect of exogenous basic fibroblast growth factor (bFGF) or transforming growth factor-beta1(TGFβ1) on wound healing. In part I of the study, ten minipigs were randomized into two equal groups, and the dural defects were reconstructed by conventional fibrin glue (FG) bonding (group I a) or by CO2 laser soldering (group Ib). In part II, 36 minipigs were randomized into three equal groups, and the dural defect was reconstructed by CO2 laser soldering; then exogenous bFGF or TGFβ1 was administered in group IIb and group IIc, respectively, while group IIa served as control group. The dural specimens were harvested at 1st week postoperatively in part I; and at 1st, 2nd, 3rd, and 4th week postoperatively in part II, they were examined for healing condition and subjected to hematoxylin-eosin (HE) staining and immunohistochemical (IHC) staining with antibodies against bFGF and TGFβ1. In part I, group Ib showed higher fibroblast cell density than group Ia (P < 0.05). The optical density (OD) for IHC staining with antibodies against bFGF of group Ib was significantly higher than that of group Ia (P < 0.05), and for IHC staining with antibodies against TGFβ1, group Ib showed positive staining while group Ia was negative. In part II, administering exogenous bFGF or TGFβ1 made a left shift of fibroblast cell number-time curve compared with control group. For specimens' IHC staining with antibodies against bFGF, the OD of group IIb was higher than that of group IIa in the corresponding time. For specimens' IHC staining with antibodies against TGFβ1, the OD of groups IIb and IIc was both higher than that of group IIa (P < 0.05 and P < 0.01, respectively). In conclusion, CO2 laser may trigger fibroblast proliferation through stimulating the secretion of bFGF and TGFβ1. Topically administering exogenous bFGF or TGFβ1 could accelerate the healing of the reconstructed dura by enhancing secretion of bFGF and/or TGFβ1 and promoting the process of fibroblast gathering-degrading.

  8. A Study of Mandarin Loanwords: Lexical Stratification, Adaptation and Factors

    ERIC Educational Resources Information Center

    Kim, Tae Eun

    2012-01-01

    This dissertation is about Chinese loanwords. It is mainly divided into two parts. Part I is a general discussion about loanwords in Chinese; Chapter I and II belong to the first part. Part II is a discussion about the analyses of Mandarin loanwords originating from English. Chapter III, IV, and V are all related to the second part. Chapter VI is…

  9. Network Centric Operations (NCO) Case Study. The British Approach to Low-Intensity Operations: Part 2

    DTIC Science & Technology

    2007-02-12

    Imperial War Museum Sound Archive, Accession No. 16397 (6 January 1996 ) 46 Jackson, p .45 47 Nagl, p .66-7 48 Stubbs, p .71 49 Nagl, p .93 Part II 16...Coogan, The Troubles, (London: Arrow, 1996 ), p .145 Part II 61 of 246 but there really appeared to be nothing in between to provide workable...Psychological Ops Capability Since 1945’, British Army Review, December 1996 , p .5 Part II 62 of 246 weakness caused by the lack of both numbers and

  10. DIVWAG Model Documentation. Volume II. Programmer/Analyst Manual. Part 1.

    DTIC Science & Technology

    1976-07-01

    that portion of the Intelligence and Control Model regulating supporting aerial fire and artillery. flight corridor: a rectangular area centered along...0.0. N N,( ON ~~ *0,U0 0 ZMN .. .6 N 6’ N N~. C4NANCy 0 -0 0 4.0 4 - 񓿀.104M 2 0 .i..i.6 C4 - - 0) 14 U.U 00 cocoa eeoc a 0iW z0 7 A 0) ;C a a . z 0...modifiers and all required data elements. (1) There are two basic rules regulating the entry of data elements when required by an order or an order modifier

  11. 20 CFR 408.101 - What is this part about?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

  12. 20 CFR 408.101 - What is this part about?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

  13. 20 CFR 408.101 - What is this part about?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

  14. 20 CFR 408.101 - What is this part about?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....101 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II... (Special Benefits for Certain World War II Veterans) established a program for the payment of benefits to certain World War II veterans. The regulations in this part are divided into the following subparts...

  15. ESTABLISHING A LIVE CARTILAGE-ON-CARTILAGE INTERFACE FOR TRIBOLOGICAL TESTING.

    PubMed

    Trevino, Robert L; Stoia, Jonathan; Laurent, Michel P; Pacione, Carol A; Chubinskaya, Susan; Wimmer, Markus A

    2017-03-01

    Mechano-biochemical wear encompasses the tribological interplay between biological and mechanical mechanisms responsible for cartilage wear and degradation. The aim of this study was to develop and start validating a novel tribological testing system, which better resembles the natural joint environment through incorporating a live cartilage-on-cartilage articulating interface, joint specific kinematics, and the application of controlled mechanical stimuli for the measurement of biological responses in order to study the mechano-biochemical wear of cartilage. The study entailed two parts. In Part 1, the novel testing rig was used to compare two bearing systems: (a) cartilage articulating against cartilage (CoC) and (b) metal articulating against cartilage (MoC). The clinically relevant MoC, which is also a common tribological interface for evaluating cartilage wear, should produce more wear to agree with clinical observations. In Part II, the novel testing system was used to determine how wear is affected by tissue viability in live and dead CoC articulations. For both parts, bovine cartilage explants were harvested and tribologically tested for three consecutive days. Wear was defined as release of glycosaminoglycans into the media and as evaluation of the tissue structure. For Part I, we found that the live CoC articulation did not cause damage to the cartilage, to the extent of being comparable to the free swelling controls, whereas the MoC articulation caused decreased cell viability, extracellular matrix disruption, and increased wear when compared to CoC, and consistent with clinical data. These results provided confidence that this novel testing system will be adequate to screen new biomaterials for articulation against cartilage, such as in hemiarthroplasty. For Part II, the live and dead cartilage articulation yielded similar wear as determined by the release of proteoglycans and aggrecan fragments, suggesting that keeping the cartilage alive may not be essential for short term wear tests. However, the biosynthesis of glycosaminoglycans was significantly higher due to live CoC articulation than due to the corresponding live free swelling controls, indicating that articulation stimulated cell activity. Moving forward, the cell response to mechanical stimuli and the underlying mechano-biochemical wear mechanisms need to be further studied for a complete picture of tissue degradation.

  16. Expression of PAT and NPT II proteins during the developmental stages of a genetically modified pepper developed in Korea.

    PubMed

    Kim, Hyo Jin; Lee, Si Myung; Kim, Jae Kwang; Ryu, Tae Hun; Suh, Seok Cheol; Cho, Hyun Suk

    2010-10-27

    Estimation of the protein levels introduced in a biotechnology-derived product is conducted as part of an overall safety assessment. An enzyme-linked immunosorbent assay (ELISA) was used to analyze phosphinothricin acetyltransferase (PAT) and neomycin phosphotransferase II (NPT II) protein expression in a genetically modified (GM) pepper plant developed in Korea. PAT and NPT II expression levels, based on both dry weight and fresh weight, were variable among different plant generations and plant sections from isolated genetically modified organism (GMO) fields at four developmental stages. PAT expression was highest in leaves at anthesis (11.44 μg/gdw and 2.17 μg/gfw) and lowest in roots (0.12 μg/gdw and 0.01 μg/gfw). NPT II expression was also highest in leaves at anthesis (17.31 μg/gdw and 3.41 μg/gfw) and lowest in red pepper (0.65 μg/gdw and 0.12 μg/gfw). In pollen, PAT expression was 0.59-0.62 μg/gdw, while NPT II was not detected. Both PAT and NPT II showed a general pattern of decreased expression with progression of the growing season. As expected, PAT and NPT II protein expression was not detectable in control pepper plants.

  17. Software Quality Control at Belle II

    NASA Astrophysics Data System (ADS)

    Ritter, M.; Kuhr, T.; Hauth, T.; Gebard, T.; Kristof, M.; Pulvermacher, C.; Belle Software Group, II

    2017-10-01

    Over the last seven years the software stack of the next generation B factory experiment Belle II has grown to over one million lines of C++ and Python code, counting only the part included in offline software releases. There are several thousand commits to the central repository by about 100 individual developers per year. To keep a coherent software stack of high quality that it can be sustained and used efficiently for data acquisition, simulation, reconstruction, and analysis over the lifetime of the Belle II experiment is a challenge. A set of tools is employed to monitor the quality of the software and provide fast feedback to the developers. They are integrated in a machinery that is controlled by a buildbot master and automates the quality checks. The tools include different compilers, cppcheck, the clang static analyzer, valgrind memcheck, doxygen, a geometry overlap checker, a check for missing or extra library links, unit tests, steering file level tests, a sophisticated high-level validation suite, and an issue tracker. The technological development infrastructure is complemented by organizational means to coordinate the development.

  18. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2013

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    no author on report

    2014-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) tomore » submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.« less

  19. Evaluation of quality of life and sexual functioning of women using levonorgestrel-releasing intrauterine contraceptive system--Mirena.

    PubMed

    Skrzypulec, Violetta; Drosdzol, Agnieszka

    2008-12-01

    The advantages ensuing from the high contraceptive efficacy, positive effect on the parameters of the menstrual cycle as well as other values of the levonorgestrel-releasing intrauterine system may play an important role in women's sexual life. The aim of the study was to evaluate the effect of the levonorgestrel-releasing intrauterine system on the quality of life and sexual functioning of women. The research encompassed 200 women aged between 30 and 45. 52 women using the levonorgestrel-releasing intrauterine system were qualified to the study as the research group (Mirena Group). The control groups consisted of 48 women using a different type of intrauterine device (Control Group I--Other IUD) and 50 women using no contraception (Control Group II). A specific questionnaire with a general part concerning socio-demographic conditions, a part dealing with contraception and Polish version of self-evaluation inventories: Short Form-36 Health Survey, Female Sexual Function Index and Mell-Krat Scale was used as a research tool. Quality of life parameters for women using the Mirena system were higher than for the control groups, especially in the aspect of general health, energy/fatigue and emotional well-being. A significant beneficial effect of the levonorgestrel-releasing intrauterine system on sexual functioning (sexual desire and arousal) was also revealed in the study. Sexual dysfunctions were diagnosed in 20.8% of Other IUD, 34.7% of Control Group II and 9.6% of Mirena Group. Levonorgestrel-releasing intrauterine system increases female quality of life and sexual functioning parameters.

  20. 12 CFR Appendix II to Part 27 - Information for Government Monitoring Purposes

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... II Appendix II to Part 27 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY... Monitoring Purposes The following language is approved by the Comptroller of the Currency and will satisfy... used separately. This information may also be provided orally by the applicant. The following...

  1. 40 CFR Appendix II to Part 86 - Temperature Schedules

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Temperature Schedules II Appendix II... to Part 86—Temperature Schedules (a) Ambient temperature cycle for the diurnal emission portion of the evaporative emission test (see § 86.133). Table I—Temperature Versus Time Sequence Use linear...

  2. 25 CFR 547.1 - What is the purpose of this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.1 What is the purpose of this part... other technologic aids in connection with the play of Class II games. This part establishes the minimum...

  3. 25 CFR 547.1 - What is the purpose of this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.1 What is the purpose of this part... other technologic aids in connection with the play of Class II games. This part establishes the minimum...

  4. 25 CFR 547.1 - What is the purpose of this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... STANDARDS FOR GAMING EQUIPMENT USED WITH THE PLAY OF CLASS II GAMES § 547.1 What is the purpose of this part... other technologic aids in connection with the play of Class II games. This part establishes the minimum...

  5. Historical perspective on asbestos: policies and protective measures in World War II shipbuilding.

    PubMed

    Corn, J K; Starr, J

    1987-01-01

    Current public health consequences of poorly controlled utilization of asbestos in the past can be traced back, in part, to decisions made 45 or more years ago. This paper focuses on the extensive use of asbestos as a fireproofing and insulating material in shipbuilding in the 1940s, when World War II industrial expansion brought about a hitherto unprecedented rise in the amount of asbestos utilized. Twenty years after World War II, asbestos diseases began to manifest themselves, affecting thousands of shipyard workers as well as other workers who had been exposed in the 1940s and during the postwar period. By scrutinizing past actions, the paper argues that social forces, as well as science and technology, affect the setting of priorities and the determination of policy regarding needed but hazardous materials.

  6. Impact of Cu(II)-doping on the vulnerability of Escherichia coli ATCC 10536 revealed by Atomic Force Microscopy.

    PubMed

    Rasheed, Wasia; Perveen, Samina; Mustafa, Ghulam; Shah, Muhammad Raza; Ahmed, Shakil; Uzzaman, Sami

    2018-05-08

    E. coli strain is a gram-negative bacterium known to induce both extra-intestinal infections and intestinal infections. For survival of microbes, metal intake and accessibility should be according to their physiological requirements. Peculiarly, copper homeostasis is critical for E. coli survival and growth. Therefore in this study, an extensive work is conducted to investigate the impact of Cu(II)-doping on the susceptibility of Escherichia coli ATCC 10536 against Cu(II)-selective Cefaclor-silver nanoconjugates (i.e., Cf-AgNPs) and its organic precursor (i.e. Cefaclor). At first, the maximal non-cytotoxic dose of Cu(II) that was sub-lethal for Escherichia coli was determined by MTT assay and was found to be 100 μg/L. Afterwards, MICs of Cf-AgNPs and Cefaclor against controlled and Cu(II)-doped E. coli cells were determined by using Agar well diffusion method. The susceptibility of E. coli cells against Cf-AgNPs was increased upon Cu(II) doping, whereas the bactericidal activity of Cefaclor against Cu(II)-doped E. coli cells was retarded due to hydrolysis. In addition, morphological changes induced in controlled and Cu(II)-doped samples of E. coli after treatment with Cefaclor and Cf-AgNPs were also monitored by Atomic force microscopy (AFM). The obtained results from both Agar well diffusion method and AFM confirmed that Cf-AgNPs are more effective against Cu(II)-doped Escherichia coli. Moreover, thermal profile of Cu(II)-selective Cf-AgNPs was also demonstrated by TGA and DSC. This study can be an important part of the relevant state-of-the-art. Indeed, further clinical studies are necessary to determine the relevant role of Cf-AgNPs compared with that of the Cefaclor now available. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Some biodiversity points and suggestions for the Myanmar Protected Area System

    Treesearch

    Daniel H. Henning

    2007-01-01

    This paper is divided into a brief background section followed by Part I: Biodiversity Points, and Part II: Suggestions that are needed for the ecological integrity of actual and potential protected areas in Myanmar. Part I consists of general and Myanmar Biodiversity Considerations, and Part II consists of the following suggestions: (l) international financial and...

  8. Understanding Medicines: Conceptual Analysis of Nurses' Needs for Knowledge and Understanding of Pharmacology (Part I). Understanding Medicines: Extending Pharmacology Education for Dependent and Independent Prescribing (Part II).

    ERIC Educational Resources Information Center

    Leathard, Helen L.

    2001-01-01

    Part I reviews what nurses need to know about the administration and prescription of medicines. Part II addresses drug classifications, actions and effects, and interactions. Also discussed are the challenges pharmacological issues pose for nursing education. (SK)

  9. Estimating Welfare Effects Consistent with Forward-Looking Behavior. Part I: Lessons from a Simulation Exercise. Part II: Empirical Results.

    ERIC Educational Resources Information Center

    Keane, Michael P.; Wolpin, Kenneth I.

    2002-01-01

    Part I uses simulations of a model of welfare participation and women's fertility decisions, showing that increases in per-child payments have substantial impact on fertility. Part II uses estimations of decision rules of forward-looking women regarding welfare participation, fertility, marriage, work, and schooling. (SK)

  10. Importance of the splanchnic vascular bed in human blood pressure regulation.

    NASA Technical Reports Server (NTRS)

    Rowell, L. B.; Detry, J.-M. R.; Blackmon, J. R.; Wyss, C.

    1972-01-01

    Three-part experiment in which five subjects were exposed to lower body negative pressure (LBNP) at -50 mm Hg below the iliac crests. Duration of LBNP to earliest vagal symptoms was 7 to 21 min; all data are expressed as changes from control period to the last measurements before these symptoms. In part I, forearm blood flow (by Whitney gauge) fell 45% during LBNP. In part II, splanchnic blood flow (from arterial clearance hepatic extraction of indocyanine green) fell 32% and splanchnic vascular resistance rose 30%. In part III, cardiac output fell 28%, stroke volume 51%, and central blood volume 21%. Total peripheral resistance and heart rate rose 19% and 52%. Of the reduction in total vascular conductance, decreased splanchnic conductance accounted for approximately 33%; skin plus muscle conductance decreased similarly.

  11. Multiple regression analysis to assess the role of plankton on the distribution and speciation of mercury in water of a contaminated lagoon.

    PubMed

    Stoichev, T; Tessier, E; Amouroux, D; Almeida, C M; Basto, M C P; Vasconcelos, V M

    2016-11-15

    Spatial and seasonal variation of mercury species aqueous concentrations and distributions was carried out during six sampling campaigns at four locations within Laranjo Bay, the most mercury-contaminated area of the Aveiro Lagoon (Portugal). Inorganic mercury (IHg(II)) and methylmercury (MeHg) were determined in filter-retained (IHgPART, MeHgPART) and filtered (<0.45μm) fractions (IHg(II)DISS, MeHgDISS). The concentrations of IHgPART depended on site and on dilution with downstream particles. Similar processes were evidenced for MeHgPART, however, its concentrations increased for particles rich in phaeophytin (Pha). The concentrations of MeHgDISS, and especially those of IHg(II)DISS, increased with Pha concentrations in the water. Multiple regression models are able to depict MeHgPART, IHg(II)DISS and MeHgDISS concentrations with salinity and Pha concentrations exhibiting additive statistical effects and allowing separation of possible addition and removal processes. A link between phytoplankton/algae and consumers' grazing pressure in the contaminated area can be involved to increase concentrations of IHg(II)DISS and MeHgPART. These processes could lead to suspended particles enriched with MeHg and to the enhancement of IHg(II) and MeHg availability in surface waters and higher transfer to the food web. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Optimal fault-tolerant control strategy of a solid oxide fuel cell system

    NASA Astrophysics Data System (ADS)

    Wu, Xiaojuan; Gao, Danhui

    2017-10-01

    For solid oxide fuel cell (SOFC) development, load tracking, heat management, air excess ratio constraint, high efficiency, low cost and fault diagnosis are six key issues. However, no literature studies the control techniques combining optimization and fault diagnosis for the SOFC system. An optimal fault-tolerant control strategy is presented in this paper, which involves four parts: a fault diagnosis module, a switching module, two backup optimizers and a controller loop. The fault diagnosis part is presented to identify the SOFC current fault type, and the switching module is used to select the appropriate backup optimizer based on the diagnosis result. NSGA-II and TOPSIS are employed to design the two backup optimizers under normal and air compressor fault states. PID algorithm is proposed to design the control loop, which includes a power tracking controller, an anode inlet temperature controller, a cathode inlet temperature controller and an air excess ratio controller. The simulation results show the proposed optimal fault-tolerant control method can track the power, temperature and air excess ratio at the desired values, simultaneously achieving the maximum efficiency and the minimum unit cost in the case of SOFC normal and even in the air compressor fault.

  13. Effects of severity of gross motor disability on anticipatory postural adjustments while standing in individuals with bilateral spastic cerebral palsy.

    PubMed

    Tomita, Hidehito; Fukaya, Yoshiki; Takagi, Yukina; Yokozawa, Asami

    2016-10-01

    Although individuals with bilateral spastic cerebral palsy (BSCP) exhibit several deficits in anticipatory postural adjustments (APAs) while standing, effects of severity of motor disability on their APAs are unclear. To determine whether individuals with BSCP exhibit severity-dependent deficits in APAs. Seven individuals with level II BSCP (BSCP-II group) and seven with level III BSCP (BSCP-III group) according to the Gross Motor Function Classification System and seven healthy controls lifted a load under two different load conditions. Anticipatory activities of the erector spinae (ES), medial hamstring (MH), and gastrocnemius (GCM) were smaller in the two BSCP groups than in the control group. Although the anticipatory GCM activity was similar between the BSCP groups, the ES and MH activities were larger in the BSCP-II group than in the BSCP-III group. In the BSCP-II group, an increase in anticipatory activity with an increase in load was observed in the MH, but not in the GCM. In the BSCP-III group, load-related modulation was not found in the MH or GCM. The present findings suggest that in individuals with BSCP with severe motor disability, APA deficits extend to more proximal parts of the body. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Validation of updated neutronic calculation models proposed for Atucha-II PHWR. Part I: Benchmark comparisons of WIMS-D5 and DRAGON cell and control rod parameters with MCNP5

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mollerach, R.; Leszczynski, F.; Fink, J.

    2006-07-01

    In 2005 the Argentine Government took the decision to complete the construction of the Atucha-II nuclear power plant, which has been progressing slowly during the last ten years. Atucha-II is a 745 MWe nuclear station moderated and cooled with heavy water, of German (Siemens) design located in Argentina. It has a pressure-vessel design with 451 vertical coolant channels, and the fuel assemblies (FA) are clusters of 37 natural UO{sub 2} rods with an active length of 530 cm. For the reactor physics area, a revision and update calculation methods and models (cell, supercell and reactor) was recently carried out coveringmore » cell, supercell (control rod) and core calculations. As a validation of the new models some benchmark comparisons were done with Monte Carlo calculations with MCNP5. This paper presents comparisons of cell and supercell benchmark problems based on a slightly idealized model of the Atucha-I core obtained with the WIMS-D5 and DRAGON codes with MCNP5 results. The Atucha-I core was selected because it is smaller, similar from a neutronic point of view, and more symmetric than Atucha-II Cell parameters compared include cell k-infinity, relative power levels of the different rings of fuel rods, and some two-group macroscopic cross sections. Supercell comparisons include supercell k-infinity changes due to the control rods (tubes) of steel and hafnium. (authors)« less

  15. Command and Control Related Computer Technology. Part I. Packet Radio. Part II. Speech Compression and Evaluation

    DTIC Science & Technology

    1975-12-01

    d g k p t VOWELS: a (father) I (bit) LIST *■ / ! ( /• 1 b d C k P t —a ( i I b d g k P t —I...7. 1 D d g k P t —I 1 ( *; 1 b d g k P t —a 1 -. -?■. 1 b d C k P --a ( y /j-; 1 b d E k...1. Nakatani, Lloyd H. and Kathleen D . Dukes, Sensitive Tes * of Speech Communication Quality. J. Acoust. Soc. Amer., Vol. 53, pp. 1083-1092,

  16. Investigation of Proprietary Admixtures. Report 2. 1977-1978 Tests.

    DTIC Science & Technology

    1980-01-01

    Laboratory CWR Work Unit 31138 P. 0. Box 631, Vicksburg, Miss. 39180 1,. CONTROLLING OFFICE NAME AND ADDRESS T Office, Chief of Engineers, U. S. Army Jam n...Tests of Proprietary Admixtures (CWR Work Unit 31138 ). The Technical Monitor for this investigation was Mr. J. A. Rhodes, DAEN-CWE-C. The...4 Scope ............. ........................... 4 Revisions and Corrections to Report I ..... ........... 5 PART II: MATERIALS, MIXTURES

  17. 40 CFR Appendix F to Subpart A of... - Listing of Ozone-Depleting Chemicals

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Listing of Ozone-Depleting Chemicals F..., Subpt. A, App. F Appendix F to Subpart A of Part 82—Listing of Ozone-Depleting Chemicals Controlled...-Monochloropentafluoroethane (CFC-115) 0.6 400.0 2.0 0.00 All isomers of the above chemicals [Reserved] 2. Group II: CF2 ClBr...

  18. 40 CFR Appendix F to Subpart A of... - Listing of Ozone-Depleting Chemicals

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Listing of Ozone-Depleting Chemicals F..., Subpt. A, App. F Appendix F to Subpart A of Part 82—Listing of Ozone-Depleting Chemicals Controlled...-Monochloropentafluoroethane (CFC-115) 0.6 400.0 2.0 0.00 All isomers of the above chemicals [Reserved] 2. Group II: CF2 ClBr...

  19. 15 CFR Supplement No. 2 to Part 742 - Anti-Terrorism Controls: North Korea, Syria and Sudan Contract Sanctity Dates and Related Policies

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... organic and inorganic fibers (kevlar) described in ECCN 1C210. (i) [Reserved] (ii) Syria. Applications for...) Contract sanctity date for high strength organic and inorganic fibers (kevlar) described in ECCN 1C210 that... Supplement. (B) Contract sanctity date for all other high strength organic and inorganic fibers (kevlar...

  20. MANUFACTURING PROCESS FUNCTIONS--I. AN ALTERNATIVE MODEL AND ITS COMPARISON WITH EXISTING FUNCTIONS (AND)II. SELECTION OF TRAINEES AND CONTROL OF THEIR PROGRESS.

    ERIC Educational Resources Information Center

    GLOVER, J.H.

    THE CHIEF OBJECTIVE OF THIS STUDY OF SPEED-SKILL ACQUISITION WAS TO FIND A MATHEMATICAL MODEL CAPABLE OF SIMPLE GRAPHIC INTERPRETATION FOR INDUSTRIAL TRAINING AND PRODUCTION SCHEDULING AT THE SHOP FLOOR LEVEL. STUDIES OF MIDDLE SKILL DEVELOPMENT IN MACHINE AND VEHICLE ASSEMBLY, AIRCRAFT PRODUCTION, SPOOLMAKING AND THE MACHINING OF PARTS CONFIRMED…

  1. [Scientific reductionism and social control of mind. Part II].

    PubMed

    Viniegra Velázquez, Leonardo

    In the second part of this essay, the progressive subordination of scientific endeavor and knowledge of business and profit is pointed out. For instance, the way facts are prioritized over concepts and ideas in scientific knowledge can translate into technological innovation, central to enterprise competitiveness and key to social mechanisms of control (military, cybernetic, ideological). Overcoming the scientific reductionism approach indicates recognizing the need to define progress in another way, one that infuses scientific knowledge with real liberating and inquisitive power. Power is essential in the search for a more collaborative, inclusive and pluralistic society where respect for human dignity and care for the ecosystem that we live in are prioritized. Copyright © 2014 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  2. Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site.

    PubMed

    Dungan, Victoria J; Ortin, Yannick; Mueller-Bunz, Helge; Rutledge, Peter J

    2010-04-07

    Non-heme iron(II) oxidases (NHIOs) catalyse a diverse array of oxidative chemistry in Nature. As part of ongoing efforts to realize biomimetic, iron-mediated C-H activation, we report the synthesis of a new 'three-amine-one-carboxylate' ligand designed to complex with iron(II) and mimic the NHIO active site. The tetradentate ligand has been prepared as a single enantiomer in nine synthetic steps from N-Cbz-L-alanine, pyridine-2,6-dimethanol and diphenylamine, using Seebach oxazolidinone chemistry to control the stereochemistry. X-Ray crystal structures are reported for two important intermediates, along with variable temperature NMR experiments to probe the hindered interconversion of conformational isomers of several key intermediates, 2,6-disubstituted pyridine derivatives. The target ligand and an N-Cbz-protected precursor were each then complexed with iron(II) and tested for their ability to promote alkene dihydroxylation, using hydrogen peroxide as the oxidant.

  3. Mediator-regulated transcription through the +1 nucleosome.

    PubMed

    Nock, Adam; Ascano, Janice M; Barrero, Maria J; Malik, Sohail

    2012-12-28

    Many genes are regulated at the level of a Pol II that is recruited to a nucleosome-free region upstream of the +1 nucleosome. How the Mediator coactivator complex, which functions at multiple steps, affects transcription through the promoter proximal region, including this nucleosome, remains largely unaddressed. We have established a fully defined in vitro assay system to delineate mechanisms for Pol II transit across the +1 nucleosome. Our results reveal cooperative functions of multiple cofactors, particularly of Mediator and elongation factor SII, in transcribing into this nucleosome. This is achieved, in part, through an unusual activity of SII that alters the intrinsic catalytic properties of promoter-proximal Pol II and, in concert with the Mediator, leads to enhancement in transcription of nucleosomal DNA. Our data provide additional mechanistic bases for Mediator function after recruitment of Pol II and, potentially, for regulation of genes controlled via nucleosome-mediated promoter-proximal pausing. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. Heating mechanism(s) for transition layers in giants

    NASA Technical Reports Server (NTRS)

    Bohm-Vitense, Erika; Mena-Werth, Jose

    1991-01-01

    The emission-line fluxes of lines originating in the lower parts of the transition layers between stellar chromospheres and coronas are studied. Simon and Drake (1989) suspect different heating mechanisms for 'hot' and cool stars. Changes in the flux ratios for the C IV to C II emission lines support this suspicion. Large C IV/C II line flux ratios appear to be indicative of magnetically controlled heating. A correlation between excess continuum flux around 1950 A and C II emission-line fluxes are confirmed for the cooler giants (late F and cooler). Excess continuum flux correlates positively with large C IV/C II line flux ratio. The excess continuum flux corresponds to an increase in temperature by several hundred degrees in layers with a mean optical depth of about 0.03. For chromospherically active stars these layers experience a mechanical flux deposition of the order of 1 percent of the total radiative flux. This flux is tentatively identified as an MHD wave flux similar to Alfven waves.

  5. ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis

    PubMed Central

    Konopacki, Filip A.; Dwivedy, Asha; Bellon, Anaïs; Blower, Michael D.

    2016-01-01

    Endocytosis and local protein synthesis (LPS) act coordinately to mediate the chemotropic responses of axons, but the link between these two processes is poorly understood. The endosomal sorting complex required for transport (ESCRT) is a key regulator of cargo sorting in the endocytic pathway, and here we have investigated the role of ESCRT-II, a critical ESCRT component, in Xenopus retinal ganglion cell (RGC) axons. We show that ESCRT-II is present in RGC axonal growth cones (GCs) where it co-localizes with endocytic vesicle GTPases and, unexpectedly, with the Netrin-1 receptor, deleted in colorectal cancer (DCC). ESCRT-II knockdown (KD) decreases endocytosis and, strikingly, reduces DCC in GCs and leads to axon growth and guidance defects. ESCRT-II-depleted axons fail to turn in response to a Netrin-1 gradient in vitro and many axons fail to exit the eye in vivo. These defects, similar to Netrin-1/DCC loss-of-function phenotypes, can be rescued in whole (in vitro) or in part (in vivo) by expressing DCC. In addition, ESCRT-II KD impairs LPS in GCs and live imaging reveals that ESCRT-II transports mRNAs in axons. Collectively, our results show that the ESCRT-II-mediated endocytic pathway regulates both DCC and LPS in the axonal compartment and suggest that ESCRT-II aids gradient sensing in GCs by coupling endocytosis to LPS. PMID:27248654

  6. Dissecting Diversity Part II

    ERIC Educational Resources Information Center

    Matthews, Frank

    2005-01-01

    This article presents "Dissecting Diversity, Part II," the conclusion of a wide-ranging two-part roundtable discussion on diversity in higher education. The participants were as follows: Lezli Baskerville, J.D., President and CEO of the National Association for Equal Opportunity (NAFEO); Dr. Gerald E. Gipp, Executive Director of the…

  7. Recent Economic Perspectives on Political Economy, Part II*

    PubMed Central

    Dewan, Torun; Shepsle, Kenneth A.

    2013-01-01

    In recent years some of the best theoretical work on the political economy of political institutions and processes has begun surfacing outside the political science mainstream in high quality economics journals. This two-part paper surveys these contributions from a recent five-year period. In Part I, the focus is on elections, voting and information aggregation, followed by treatments of parties, candidates, and coalitions. In Part II, papers on economic performance and redistribution, constitutional design, and incentives, institutions, and the quality of political elites are discussed. Part II concludes with a discussion of the methodological bases common to economics and political science, the way economists have used political science research, and some new themes and arbitrage opportunities. PMID:23606754

  8. Proceedings of the Meeting of the Coordinating Group on Modern Control Theory (4th) Held at Rochester, Michigan, on 27-28 October 1982. Part II,

    DTIC Science & Technology

    1983-01-01

    DCUMNTATON AGEREAD INSTRUCTIONS ______ REPORT___DOCUMENTATION _____PAGE_ BEFORE COMPLETKNG FORM 1REPORT NUMBER ILGOVT ACCESSION No. 3 . RECIPIENT’S...Herbert E. Cohen) control 0900 - Endgame Performance Study of a Special Class of Interceptors by Dr. Jonathan Korn ALPHATECH, Inc. 3 New England Executive...tactile/force feedback sensor applications. 3 L i7 TYPICAL GRIPPER FACE (NOT IN GRIPPER B3OLTS 00 BASE SLIP Nm mSENSORS "o 0 TORQUE, GRIP 0 fie d e

  9. 40 CFR Appendix B to Subpart II of... - Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density B Appendix B to Subpart II of Part 63 Protection of... Shipbuilding and Ship Repair (Surface Coating) Pt. 63, Subpt. II, App. B Appendix B to Subpart II of Part 63...

  10. 40 CFR Appendix B to Subpart II to... - Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Maximum Allowable Thinning Rates as a Function of As Supplied VOC Content and Thinner Density B Appendix B to Subpart II to Part 63 Protection of... Shipbuilding and Ship Repair (Surface Coating) Pt. 63, Subpt. II, App. B Appendix B to Subpart II to Part 63...

  11. Chimeric Lyssavirus Glycoproteins with Increased Immunological Potential

    PubMed Central

    Jallet, Corinne; Jacob, Yves; Bahloul, Chokri; Drings, Astrid; Desmezieres, Emmanuel; Tordo, Noël; Perrin, Pierre

    1999-01-01

    The rabies virus glycoprotein molecule (G) can be divided into two parts separated by a flexible hinge: the NH2 half (site II part) containing antigenic site II up to the linear region (amino acids [aa] 253 to 275 encompassing epitope VI [aa 264]) and the COOH half (site III part) containing antigenic site III and the transmembrane and cytoplasmic domains. The structural and immunological roles of each part were investigated by cell transfection and mouse DNA-based immunization with homogeneous and chimeric G genes formed by fusion of the site II part of one genotype (GT) with the site III part of the same or another GT. Various site II-site III combinations between G genes of PV (Pasteur virus strain) rabies (GT1), Mokola (GT3), and EBL1 (European bat lyssavirus 1 [GT5]) viruses were tested. Plasmids pGPV-PV, pGMok-Mok, pGMok-PV, and pGEBL1-PV induced transient expression of correctly transported and folded antigens in neuroblastoma cells and virus-neutralizing antibodies against parental viruses in mice, whereas, pG-PVIII (site III part only) and pGPV-Mok did not. The site III part of PV (GT1) was a strong inducer of T helper cells and was very effective at presenting the site II part of various GTs. Both parts are required for correct folding and transport of chimeric G proteins which have a strong potential value for immunological studies and development of multivalent vaccines. Chimeric plasmid pGEBL1-PV broadens the spectrum of protection against European lyssavirus genotypes (GT1, GT5, and GT6). PMID:9847325

  12. Study on the pollution status and control measures for the livestock and poultry breeding industry in northeastern China.

    PubMed

    Wang, Hanxi; Xu, Jianling; Liu, Xuejun; Sheng, Lianxi; Zhang, Di; Li, Longwei; Wang, Aixia

    2018-02-01

    Livestock and poultry breeding industry is one of the main economic pillars of northeastern China. However, the amount of pollutants produced is much higher than that in other parts of China. Through a questionnaire survey, indoor experiment, and outdoor experiment, it was found that the resource utilization rate of livestock and poultry manure in the northeastern region is low, with the pollution of livestock and poultry breeding mainly including air and water pollution. The alarm level of cultivated land and manure is II. While the livestock and poultry breeding is relatively concentrated area, its level is higher than grade II. Based on the pollution status of small farms, biogas can be produced through fermentation, along with the preparation of organic fertilizer, to completely utilize the manure and straw, while obtaining higher economic value, and effectively controlling the pollution from livestock and poultry breeding.

  13. A multi-sensor study of the impact of ground-based glaciogenic seeding on clouds and precipitation over mountains in Wyoming. Part II: Seeding impact analysis

    NASA Astrophysics Data System (ADS)

    Pokharel, Binod; Geerts, Bart; Jing, Xiaoqin; Friedrich, Katja; Ikeda, Kyoko; Rasmussen, Roy

    2017-01-01

    The AgI Seeding Cloud Impact Investigation (ASCII) campaign, conducted in early 2012 and 2013 over two mountain ranges in southern Wyoming, was designed to examine the impact of ground-based glaciogenic seeding on snow growth in winter orographic clouds. Part I of this study (Pokharel and Geerts, 2016) describes the project design, instrumentation, as well as the ambient atmospheric conditions and macrophysical and microphysical properties of the clouds sampled in ASCII. This paper (Part II) explores how the silver iodide (AgI) seeding affects snow growth in these orographic clouds in up to 27 intensive operation periods (IOPs), depending on the instrument used. In most cases, 2 h without seeding (NOSEED) were followed by 2 h of seeding (SEED). In situ data at flight level (2D-probes) indicate higher concentrations of small snow particles during SEED in convective clouds. The double difference of radar reflectivity Z (SEED - NOSEED in the target region, compared to the same trend in the control region) indicates an increase in Z for the composite of ASCII cases, over either mountain range, and for any of the three radar systems (WCR, MRR, and DOW), each with their own control and target regions, and for an array of snow gauges. But this double difference varies significantly from case to case, which is attributed to uncertainties related to sampling representativeness and to differences in natural trends between control and target regions. We conclude that a sample much larger than ASCII's sample is needed for clear observational evidence regarding the sensitivity of seeding efficacy to atmospheric and cloud conditions.

  14. Cognitive functioning in opioid-dependent patients treated with buprenorphine, methadone, and other psychoactive medications: stability and correlates

    PubMed Central

    2011-01-01

    Background In many but not in all neuropsychological studies buprenorphine-treated opioid-dependent patients have shown fewer cognitive deficits than patients treated with methadone. In order to examine if hypothesized cognitive advantage of buprenorphine in relation to methadone is seen in clinical patients we did a neuropsychological follow-up study in unselected sample of buprenorphine- vs. methadone-treated patients. Methods In part I of the study fourteen buprenorphine-treated and 12 methadone-treated patients were tested by cognitive tests within two months (T1), 6-9 months (T2), and 12 - 17 months (T3) from the start of opioid substitution treatment. Fourteen healthy controls were examined at similar intervals. Benzodiazepine and other psychoactive comedications were common among the patients. Test results were analyzed with repeated measures analysis of variance and planned contrasts. In part II of the study the patient sample was extended to include 36 patients at T2 and T3. Correlations between cognitive functioning and medication, substance abuse, or demographic variables were then analyzed. Results In part I methadone patients were inferior to healthy controls tests in all tests measuring attention, working memory, or verbal memory. Buprenorphine patients were inferior to healthy controls in the first working memory task, the Paced Auditory Serial Addition Task and verbal memory. In the second working memory task, the Letter-Number Sequencing, their performance improved between T2 and T3. In part II only group membership (buprenorphine vs. methadone) correlated significantly with attention performance and improvement in the Letter-Number Sequencing. High frequency of substance abuse in the past month was associated with poor performance in the Letter-Number Sequencing. Conclusions The results underline the differences between non-randomized and randomized studies comparing cognitive performance in opioid substitution treated patients (fewer deficits in buprenorphine patients vs. no difference between buprenorphine and methadone patients, respectively). Possible reasons for this are discussed. PMID:21854644

  15. Part 1: Vadose-zone column studies of toluene (enhanced bioremediation) in a shallow unconfined aquifer

    USGS Publications Warehouse

    Tindall, J.A.; Friedel, M.J.; Szmajter, R.J.; Cuffin, S.M.

    2005-01-01

    The objectives of the laboratory study described in this paper were (1) to determine the effectiveness of four nutrient solutions and a control in stimulating the microbial degradation of toluene in the unsaturated zone as an alternative to bioremediation methodologies such as air sparging, in situ vitrification, or others (Part I), and (2) to compare the effectiveness of the addition of the most effective nutrient solution from Part I (modified Hoagland type, nitrate-rich) and hydrogen peroxide (H2O2) on microbial degradation of toluene for repeated, simulated spills in the unsaturated zone (Part II). For Part 1, fifteen columns (30-cm diameter by 150-cm height), packed with air-dried, 0.25-mm, medium-fine sand, were prepared to simulate shallow unconfined aquifer conditions. Toluene (10 mL) was added to the surface of each column, and soil solution and soil gas samples were collected from the columns every third day for 21 days. On day 21, a second application of toluene (10 mL) was made, and the experiment was run for another 21 days. Solution 4 was the most effective for microbial degradation in Part I. For Part II, three columns were designated nutrient-rich 3-day toluene columns and received toluene injections every 3 days; three columns were designated as nutrient-rich 7-day columns and received toluene injections every 7 days; and two columns were used as controls to which no nutrient was added. As measured by CO2 respiration, the initial benefits for aerobic organisms from the O2 enhancement were sustained by the bacteria for only a short period of time (about 8 days). Degradation benefits from the nutrient solution were sustained throughout the experiment. The O2 and nutrient-enhanced columns degraded significantly more toluene than the control columns when simulating repeated spills onto the unsaturated zone, and demonstrated a potentially effective in situ bioremediation technology when used immediately or within days after a spill. The combined usage of H 2O2 and nitrate-rich nutrients served to effectively maximize natural aerobic and anaerobic metabolic processes that biodegrade hydrocarbons in petroleum-contaminated media. Applications of this technology in the field may offer economical advantages to other, more intrusive abatement technologies. ?? Springer 2005.

  16. Unlearning Established Organizational Routines--Part II

    ERIC Educational Resources Information Center

    Fiol, C. Marlena; O'Connor, Edward J.

    2017-01-01

    Purpose: The purpose of Part II of this two-part paper is to uncover important differences in the nature of the three unlearning subprocesses, which call for different leadership interventions to motivate people to move through them. Design/methodology/approach: The paper draws on research in behavioral medicine and psychology to demonstrate that…

  17. Inhibitory Effects of Low Decibel Infrasound on the Cardiac Fibroblasts and the Involved Mechanism

    PubMed Central

    Jin, Wei; Deng, Qin-Qin; Chen, Bao-Ying; Lu, Zhen-Xing; Li, Qing; Zhao, Hai-Kang; Chang, Pan; Yu, Jun; Pei, Zhao-Hui

    2017-01-01

    Introduction: Infrasound is a mechanical vibration wave with frequency between 0.0001 and 20 Hz. It has been established that infrasound of 120 dB or stronger is dangerous to humans. However, the biological effects of low decibel infrasound are largely unknown. The purpose of this study was to investigate the effects of low decibel infrasound on the cardiac fibroblasts. Materials and Methods: The cardiac fibroblasts were isolated and cultured from Sprague–Dawley rats. The cultured cells were assigned into the following four groups: control group, angiotensin II (Ang II) group, infrasound group, and Ang II+infrasound group. The cell proliferation and collagen synthesis rates were evaluated by means of [3H]-thymidine and [3H]-proline incorporation, respectively. The levels of TGF-β were determined by enzyme-linked immunosorbent assay. Moreover, RNAi approaches were used for the analysis of the biological functions of miR-29a, and the phosphorylation status of Smad3 was detected using western blotting analysis. Results: The results showed that low decibel infrasound significantly alleviated Ang II-induced enhancement of cell proliferation and collagen synthesis. Discussion: Compared with the control, Ang II markedly decreased the expression of miR-29a levels and increased the secretion of TGF-β and phosphorylation of Smad3, which was partly reversed by the treatment with low decibel infrasound. Importantly, knockdown of miR-29a diminished the effects of infrasound on the cardiac fibroblasts. In conclusion, low decibel infrasound inhibits Ang II-stimulated cardiac fibroblasts via miR-29a targeting TGF-β/Smad3 signaling. PMID:28615545

  18. Inhibitory effects of low decibel infrasound on the cardiac fibroblasts and the involved mechanism.

    PubMed

    Jin, Wei; Deng, Qin-Qin; Chen, Bao-Ying; Lu, Zhen-Xing; Li, Qing; Zhao, Hai-Kang; Chang, Pan; Yu, Jun; Pei, Zhao-Hui

    2017-01-01

    Infrasound is a mechanical vibration wave with frequency between 0.0001 and 20 Hz. It has been established that infrasound of 120 dB or stronger is dangerous to humans. However, the biological effects of low decibel infrasound are largely unknown. The purpose of this study was to investigate the effects of low decibel infrasound on the cardiac fibroblasts. The cardiac fibroblasts were isolated and cultured from Sprague-Dawley rats. The cultured cells were assigned into the following four groups: control group, angiotensin II (Ang II) group, infrasound group, and Ang II+infrasound group. The cell proliferation and collagen synthesis rates were evaluated by means of [3H]-thymidine and [3H]-proline incorporation, respectively. The levels of TGF-β were determined by enzyme-linked immunosorbent assay. Moreover, RNAi approaches were used for the analysis of the biological functions of miR-29a, and the phosphorylation status of Smad3 was detected using western blotting analysis. The results showed that low decibel infrasound significantly alleviated Ang II-induced enhancement of cell proliferation and collagen synthesis. Compared with the control, Ang II markedly decreased the expression of miR-29a levels and increased the secretion of TGF-β and phosphorylation of Smad3, which was partly reversed by the treatment with low decibel infrasound. Importantly, knockdown of miR-29a diminished the effects of infrasound on the cardiac fibroblasts. In conclusion, low decibel infrasound inhibits Ang II-stimulated cardiac fibroblasts via miR-29a targeting TGF-β/Smad3 signaling.

  19. Free-Piston Stirling Power Conversion Unit for Fission Power System, Phase II Final Report

    NASA Technical Reports Server (NTRS)

    Wood, J. Gary; Stanley, John

    2016-01-01

    In Phase II, the manufacture and testing of two 6-kW(sub e)Stirling engines was completed. The engines were delivered in an opposed 12-kW(sub e) arrangement with a common expansion space heater head. As described in the Phase I report, the engines were designed to be sealed both hermetically and with a bolted O-ring seal. The completed Phase II convertor is in the bolted configuration to allow future disassembly. By the end of Phase II, the convertor had passed all of the final testing requirements in preparation for delivery to the NASA Glenn Research Center. The electronic controller also was fabricated and tested during Phase II. The controller sets both piston amplitudes and maintains the phasing between them. It also sets the operating frequency of the machine. Details of the controller are described in the Phase I final report. Fabrication of the direct-current to direct-current (DC-DC) output stage, which would have stepped down the main controller output voltage from 700 to 120 V(sub DC), was omitted from this phase of the project for budgetary reasons. However, the main controller was successfully built, tested with the engines, and delivered. We experienced very few development issues with this high-power controller. The project extended significantly longer than originally planned because of yearly funding delays. The team also experienced several hardware difficulties along the development path. Most of these were related to the different thermal expansions of adjacent parts constructed of different materials. This issue was made worse by the large size of the machine. Thermal expansion problems also caused difficulties in the brazing of the opposed stainless steel sodium-potassium (NaK) heater head. Despite repeated attempts Sunpower was not able to successfully braze the opposed head under this project. Near the end of the project, Glenn fabricated an opposed Inconel NaK head, which was installed prior to delivery for testing at Glenn. Engine development prior to this was performed using both single- and dual-opposed (common expansion space) Inconel heads with clamp-on electric heaters.

  20. Highly anisotropic exchange interactions in a trigonal bipyramidal cyanide-bridged Ni(II)3Os(III)2 cluster.

    PubMed

    Palii, Andrei V; Reu, Oleg S; Ostrovsky, Sergei M; Klokishner, Sophia I; Tsukerblat, Boris S; Hilfiger, Matthew; Shatruk, Michael; Prosvirin, Andrey; Dunbar, Kim R

    2009-06-25

    This article is a part of our efforts to control the magnetic anisotropy in cyanide-based exchange-coupled systems with the eventual goal to obtain single-molecule magnets with higher blocking temperatures. We give the theoretical interpretation of the magnetic properties of the new pentanuclear complex {[Ni(II)(tmphen)(2)](3)[Os(III)(CN)(6)](2)} x 6 CH(3)CN (Ni(II)(3)Os(III)(2) cluster). Because the system contains the heavy Os(III) ions, spin-orbit coupling considerably exceeds the contributions from the low-symmetry crystal field and exchange coupling. The magnetic properties of the Ni(II)(3)Os(III)(2) cluster are described in the framework of a highly anisotropic pseudo-spin Hamiltonian that corresponds to the limit of strong spin-orbital coupling and takes into account the complex molecular structure. The model provides a good fit to the experimental data and allows the conclusion that the trigonal axis of the bipyramidal Ni(II)(3)Os(III)(2) cluster is a hard axis of magnetization. This explains the fact that in contrast with the isostructural trigonal bipyramidal Mn(III)(2)Mn(II)(3) cluster, the Ni(II)(3)Os(III)(2) system does not exhibit the single-molecule magnetic behavior.

  1. 14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

  2. 14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

  3. 14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

  4. 14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

  5. 14 CFR Appendix A to Part 91 - Category II Operations: Manual, Instruments, Equipment, and Maintenance

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... authorization for the type aircraft checked. (3) A schedule that provides for the performance of bench checks..., Equipment, and Maintenance A Appendix A to Part 91 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... Maintenance 1. Category II Manual (a) Application for approval. An applicant for approval of a Category II...

  6. 40 CFR Appendix II to Part 1045 - Duty Cycles for Propulsion Marine Engines

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Propulsion Marine... Pt. 1045, App. II Appendix II to Part 1045—Duty Cycles for Propulsion Marine Engines (a) The following duty cycle applies for discrete-mode testing: E4 Mode No. Enginespeed 1 Torque(percent) 2...

  7. 40 CFR Appendix II to Part 1039 - Steady-State Duty Cycles

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Steady-State Duty Cycles II Appendix... Appendix II to Part 1039—Steady-State Duty Cycles (a) The following duty cycles apply for constant-speed engines: (1) The following duty cycle applies for discrete-mode testing: D2 mode number Engine speed...

  8. Coordinator(a) de Servicios Clinicos. Parte I (Unidad I-IV). Parte II (Unidad V-VI). Guia. Documento de Trabajo (Clinical Services Coordinator. Part I. Units I-IV. Part II. Units V-VI. Guide. Working Document).

    ERIC Educational Resources Information Center

    Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

    This guide is intended for instructing secondary students in the occupation of clinical services coordinator in a hospital. The first part contains four units on the following subjects: the occupation of clinical services coordinator; interpersonal relationships; ethical/legal aspects; and communications (telephone, intercom, and others). For each…

  9. Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.

    PubMed

    Stanhewicz, Anna E; Jandu, Sandeep; Santhanam, Lakshmi; Alexander, Lacy M

    2017-08-01

    Women who have had preeclampsia have increased cardiovascular disease risk; however, the mechanism(s) responsible for this association remain unclear. Microvascular damage sustained during a preeclamptic pregnancy may persist postpartum. The putative mechanisms mediating this dysfunction include a reduction in NO-dependent dilation and an increased sensitivity to angiotensin II. In this study, we evaluated endothelium-dependent dilation, angiotensin II sensitivity, and the therapeutic effect of angiotensin II receptor blockade (losartan) on endothelium-dependent dilation in vivo in the microvasculature of women with a history of preeclampsia (n=12) and control women who had a healthy pregnancy (n=12). We hypothesized that preeclampsia would have (1) reduced endothelium-dependent dilation, (2) reduced NO-mediated dilation, and (3) increased sensitivity to angiotensin II. We further hypothesized that localized losartan would increase endothelium-dependent vasodilation in preeclampsia. We assessed microvascular endothelium-dependent vasodilator function by measurement of cutaneous vascular conductance responses to graded infusion of acetylcholine (acetylcholine; 10 -7 -102 mmol/L) and a standardized local heating protocol in control sites and sites treated with 15 mmol/L L-NAME ( N G -nitro-l-arginine methyl ester; NO-synthase inhibitor) or 43 µmol/L losartan. Further, we assessed microvascular vasoconstrictor sensitivity to angiotensin II (10 -20 -10 -4 mol/L). Preeclampsia had significantly reduced endothelium-dependent dilation (-0.3±0.5 versus -1.0±0.4 log EC50 ; P <0.001) and NO-dependent dilation (16±3% versus 39±6%; P =0.006). Preeclampsia also had augmented vasoconstrictor sensitivity to angiotensin II (-10.2±1.3 versus -8.3±0.5; P =0.006). Angiotensin II type I receptor inhibition augmented endothelium-dependent vasodilation and NO-dependent dilation in preeclampsia but had no effect in healthy pregnancy. These data suggest that women who have had preeclampsia have persistent microvascular dysfunction postpartum, mediated, in part, by increased sensitivity to angiotensin II. © 2017 American Heart Association, Inc.

  10. Reproduction in the space environment: Part II. Concerns for human reproduction

    NASA Technical Reports Server (NTRS)

    Jennings, R. T.; Santy, P. A.

    1990-01-01

    Long-duration space flight and eventual colonization of our solar system will require successful control of reproductive function and a thorough understanding of factors unique to space flight and their impact on gynecologic and obstetric parameters. Part II of this paper examines the specific environmental factors associated with space flight and the implications for human reproduction. Space environmental hazards discussed include radiation, alteration in atmospheric pressure and breathing gas partial pressures, prolonged toxicological exposure, and microgravity. The effects of countermeasures necessary to reduce cardiovascular deconditioning, calcium loss, muscle wasting, and neurovestibular problems are also considered. In addition, the impact of microgravity on male fertility and gamete quality is explored. Due to current constraints, human pregnancy is now contraindicated for space flight. However, a program to explore effective countermeasures to current constraints and develop the required health care delivery capability for extended-duration space flight is suggested. A program of Earth- and space-based research to provide further answers to reproductive questions is suggested.

  11. Managing EEE part standardisation and procurement

    NASA Astrophysics Data System (ADS)

    Serieys, C.; Bensoussan, A.; Petitmangin, A.; Rigaud, M.; Barbaresco, P.; Lyan, C.

    2002-12-01

    This paper presents the development activities in space components selection and procurement dealing with a new data base tool implemented at Alcatel Space using TransForm softwaa re configurator developed by Techform S.A. Based on TransForm, Access Ingenierie has devv eloped a software product named OLG@DOS which facilitate the part nomenclatures analyses for new equipment design and manufacturing in term of ACCESS data base implementation. Hi-Rel EEE part type technical, production and quality information are collected and compiled usingproduction data base issued from production tools implemented for equipment definition, description and production based on Manufacturing Resource Planning (MRP II Control Open) and Parametric Design Manager (PDM Work Manager). The analysis of any new equipment nomenclature may be conducted through this means for standardisation purpose, cost containment program and management procurement activities as well as preparation of Component reviews as Part Approval Document and Declared Part List validation.

  12. Prospective case-control study of efficacy of bilateral selective neck dissection in primary surgical treatment of supraglottic laryngeal cancers with clinically negative cervical findings (N0).

    PubMed

    Djordjevic, V; Bukurov, B; Arsovic, N; Dimitrijevic, M; Jesic, S; Nesic, V; Petrovic, Z

    2016-12-01

    To evaluate the efficacy of bilateral selective neck dissection of levels II-IV in elective and therapeutic management of the neck as a part of primary surgical treatment of patients with supraglottic laryngeal cancer and clinically negative cervical findings (N0). Institutional, observational, case-control study with historic control of patients who underwent primary supraglottic tumour surgery, and a prospective cohort of patient, who underwent, besides the operation of primary tumour, bilateral selective neck dissection (level II-IV). University, tertiary level hospital, national referral centre. The study included 193 patients with supraglottic cancer and without palpable or ultrasound positive cervical findings who were surgically treated from 1988 to 2005. Besides the operation of primary tumour, all patients in the study group underwent bilateral selective neck dissection (level II-IV). Patients in the control group (N = 51) underwent primary tumour operation only and were followed up regularly. In cases with postoperative regional recurrences, the radical neck dissection was performed. All patients with histopathological confirmation of occult metastases were administered radiotherapy treatment (60 Gy) in the postoperative period. Five-year overall survival rate. Occult cervical metastases were found in 18% of patients. They were present in level II in 77.5%, in level III in 20% of cases and in one patient in level IV (2.5%); the extracapsular spread was observed in 20% of cases. Postoperative regional metastases were found in 4.15% of cases in the study group, and in 11.8% in the control group, which proved to be significantly higher. The five-year overall survival rate showed no significant difference between the study group and the control group. The incidence of postoperative regional recurrences could be reduced by performing bilateral selective neck dissection simultaneously with primary tumour operation, but with no influence on the survival rate. © 2015 John Wiley & Sons Ltd.

  13. Generalized fourier analyses of the advection-diffusion equation - Part II: two-dimensional domains

    NASA Astrophysics Data System (ADS)

    Voth, Thomas E.; Martinez, Mario J.; Christon, Mark A.

    2004-07-01

    Part I of this work presents a detailed multi-methods comparison of the spatial errors associated with the one-dimensional finite difference, finite element and finite volume semi-discretizations of the scalar advection-diffusion equation. In Part II we extend the analysis to two-dimensional domains and also consider the effects of wave propagation direction and grid aspect ratio on the phase speed, and the discrete and artificial diffusivities. The observed dependence of dispersive and diffusive behaviour on propagation direction makes comparison of methods more difficult relative to the one-dimensional results. For this reason, integrated (over propagation direction and wave number) error and anisotropy metrics are introduced to facilitate comparison among the various methods. With respect to these metrics, the consistent mass Galerkin and consistent mass control-volume finite element methods, and their streamline upwind derivatives, exhibit comparable accuracy, and generally out-perform their lumped mass counterparts and finite-difference based schemes. While this work can only be considered a first step in a comprehensive multi-methods analysis and comparison, it serves to identify some of the relative strengths and weaknesses of multiple numerical methods in a common mathematical framework. Published in 2004 by John Wiley & Sons, Ltd.

  14. Evaluation of estimated energy conservation measure costs and benefits in the residential multifamily sector

    NASA Astrophysics Data System (ADS)

    1982-09-01

    Supporting data for a policy review to determine how the multifamily buildings subsector is responding to market signals was sought. What role, if any, the federal government should play in encouraging conservation in multifamily buildings is discussed. The policy review seeks to develop an understanding of the current level of and trends in energy conservation activity in multifamily housing. The availability of the required data is determined and information in a form which facilitates its use by policy analysts is compiled. The results are presented in four parts. Part I provides an overview. Part II presents, in tabular form, the cost of selected retrofit items and the resulting energy and cost savings. As an aid to understanding the data in Part II, the salient assumptions underlying the data are also included in this part. Part III describes how the data in Part II were developed.

  15. 40 CFR Table II-1 to Subpart II of... - Emission Factors

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table II-1...

  16. 40 CFR Table II-1 to Subpart II of... - Emission Factors

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Emission Factors II Table II-1 to Subpart II of Part 98 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Industrial Wastewater Treatment Pt. 98, Subpt. II, Table II-1...

  17. 42 CFR 423.509 - Termination of contract by CMS.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Part D plan in writing 90 days before the intended date of the termination. (ii) The Part D plan... sponsor; (B) The Part D plan sponsor experiences financial difficulties so severe that its ability to make...)(4) of this section. (ii) CMS notifies the MA organization in writing that its contract will be...

  18. 5 CFR 330.602 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... equivalent) or below who: (i) Received a reduction in force (RIF) separation notice under part 351 of this... positions; and (ii) Received a RIF separation notice under part 351 of this chapter or a notice of proposed...); or (ii) Received a RIF notice of separation under part 351 of this chapter or a notice of proposed...

  19. 5 CFR 330.602 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... equivalent) or below who: (i) Received a reduction in force (RIF) separation notice under part 351 of this... positions; and (ii) Received a RIF separation notice under part 351 of this chapter or a notice of proposed...); or (ii) Received a RIF notice of separation under part 351 of this chapter or a notice of proposed...

  20. 5 CFR 330.602 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... equivalent) or below who: (i) Received a reduction in force (RIF) separation notice under part 351 of this... positions; and (ii) Received a RIF separation notice under part 351 of this chapter or a notice of proposed...); or (ii) Received a RIF notice of separation under part 351 of this chapter or a notice of proposed...

  1. Market Analysis and Consumer Impacts Source Document. Part II. Review of Motor Vehicle Market and Consumer Expenditures on Motor Vehicle Transportation

    DOT National Transportation Integrated Search

    1980-12-01

    This source document on motor vehicle market analysis and consumer impacts consists of three parts. Part II consists of studies and review on: motor vehicle sales trends; motor vehicle fleet life and fleet composition; car buying patterns of the busi...

  2. Calculus of Elementary Functions, Part II. Teacher's Commentary. Revised Edition.

    ERIC Educational Resources Information Center

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This teacher's guide is for Part II of the course. It is designed to follow Part I of the text. The guide contains background information, suggested instructional…

  3. Calculus of Elementary Functions, Part II. Student Text. Revised Edition.

    ERIC Educational Resources Information Center

    Herriot, Sarah T.; And Others

    This course is intended for students who have a thorough knowledge of college preparatory mathematics, including algebra, axiomatic geometry, trigonometry, and analytic geometry. This text, Part II, contains material designed to follow Part I. Chapters included in this text are: (6) Derivatives of Exponential and Related Functions; (7) Area and…

  4. [Pre-surgical orthodontic treatment of skeletal class II patients with gingival smile corrected by anterior maxillary segmental osteotomy].

    PubMed

    Li, Xiaobing; Xiao, Liwei; Chen, Song; Chen, Yangxi

    2002-11-01

    To discuss the pre-surgical orthodontic treatment of skeletal class II patients with gingiva smile corrected by AMSO. We analyzed the clinical features of 20 skeletal class II patients treated by AMSO combined with Orthodontic treatment and evaluated the effects of AMSO by means of cephalometric analysis. After the AMSO treatment, ANB angle, the height of anterior maxilla, the protrusion of the upper anterior teeth, and the of A point had reduced significantly (P < 0.05). After AMSO, the appearance of patients had been improved markedly. AMSO can correct the protrusion of the maxilla and gingival smie efficiently. The anchorage of molars should be controlled carefully. The anterior part of the upper arch should be expended orthodontically to make arch relationship. Extract the upper bicuspid half a year before the surgery was recommended. When necessary, genioplasty could be performed.

  5. ATLAS Beam Steering Mechanism (BSM) Lessons Learned

    NASA Technical Reports Server (NTRS)

    Blumenstock, Kenneth A.; Cramer, Alexander K.; Gosten, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morell, Armando; hide

    2016-01-01

    This paper describes the design, testing, and lessons learned during the development of the Advanced Topographic Laser Altimeter System (ATLAS) Beam Steering Mechanism (BSM). The BSM is a 2 degree-of-freedom tip-tilt mechanism for the purpose of pointing a flat mirror to tightly control the co-alignment of the transmitted laser and the receiver telescope of the ATLAS instrument. The high resolution needs of the mission resulted in sub-arcsecond pointing and knowledge requirements, which have been met. Development of the methodology to verify performance required significant effort. The BSM will fly as part of the Ice, Cloud, and Elevation Satellite II Mission (ICESat II), which is scheduled to be launched in 2017. The ICESat II primary mission is to map the Earth's surface topography for the determination of seasonal changes of ice sheet thickness and vegetation canopy thickness to establish long-term trends.

  6. ATLAS Beam Steering Mechanism Lessons Learned

    NASA Technical Reports Server (NTRS)

    Blumenstock, Kenneth A.; Cramer, Alexander K.; Gostin, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morrell, Armando; hide

    2016-01-01

    This paper describes the design, testing, and lessons learned during the development of the Advanced Topographic Laser Altimeter System (ATLAS) Beam Steering Mechanism (BSM). The BSM is a 2 degree-of-freedom tip-tilt mechanism for the purpose of pointing a flat mirror to tightly control the co-alignment of the transmitted laser and the receiver telescope of the ATLAS instrument. The high resolution needs of the mission resulted in sub-arcsecond pointing and knowledge requirements, which have been met. Development of the methodology to verify performance required significant effort. The BSM will fly as part of the Ice, Cloud, and Elevation Satellite II Mission (ICESat II), which is scheduled to be launched in 2017. The ICESat II primary mission is to map the earth's surface topography for the determination of seasonal changes of ice sheet thickness and vegetation canopy thickness to establish long-term trends.

  7. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids.

    PubMed

    Sorochinsky, Alexander E; Aceña, José Luis; Moriwaki, Hiroki; Sato, Tatsunori; Soloshonok, Vadim

    2013-11-01

    This review provides a comprehensive treatment of literature data dealing with asymmetric synthesis of α-amino-β-hydroxy and α,β-diamino acids via homologation of chiral Ni(II) complexes of glycine Schiff bases using aldol and Mannich-type reactions. These reactions proceed with synthetically useful chemical yields and thermodynamically controlled stereoselectivity and allow direct introduction of two stereogenic centers in a single operation with predictable stereochemical outcome. Furthermore, new application of Ni(II) complexes of α-amino acids Schiff bases for deracemization of racemic α-amino acids and (S) to (R) interconversion providing additional synthetic opportunities for preparation of enantiomerically pure α-amino acids, is also reviewed. Origin of observed diastereo-/enantioselectivity in the aldol, Mannich-type and deracemization reactions, generality and limitations of these methodologies are critically discussed.

  8. Controlling Salmonella infection in weanling pigs through water delivery of direct-fed microbials or organic acids: Part II. Effects on intestinal histology and active nutrient transport

    USDA-ARS?s Scientific Manuscript database

    The objective of this study was to evaluate the effects of water-delivered direct-fed microbials (DFM) or organic acids on intestinal morphology and active nutrient absorption in weanling pigs following deliberate Salmonella infection. Pigs (n = 88) were weaned at 19 ± 2 d of age and assigned to one...

  9. Proceedings of the 1990 Annual Meeting of the Association for Education in Journalism and Mass Communication (73rd, Minneapolis, Minnesota, August 1-4, 1990). Part II: Mass Media Studies.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The mass media studies section of the proceedings includes the following 14 papers: "Media Use, Political Activity and the 'Climate of Opinion'" (Robert L. Stevenson and William J. Gonzenbach); "Seeing Is Believing: News as Cultural Ritual in Times of Disaster" (Sandra L. Haarsager); "Creativity and Creative Control in the…

  10. A testbed for the evaluation of computer aids for enroute flight path planning

    NASA Technical Reports Server (NTRS)

    Smith, Philip J.; Layton, Chuck; Galdes, Deb; Mccoy, C. E.

    1990-01-01

    A simulator study of the five airline flight crews engaged in various enroute planning activities has been conducted. Based on a cognitive task analysis of this data, a flight planning workstation has been developed on a Mac II controlling three color monitors. This workstation is being used to study design concepts to support the flight planning activities of dispatchers and flight crews in part-task simulators.

  11. Ada (Trademark) Case Studies II.

    DTIC Science & Technology

    1984-01-01

    number ( CSN ) in that character set’s "transmission identifier". The array is named START CSN , but a better name would be STARTOFCSN. The word of...protocols), CSN (Channel Sequence Number), EON (End of Message), LMF (Line Media Format), MCB (Message Control Block), RI (Routing Indicator), and TI...component names should end with -PART, - FIELD , or COMPONENT.El - Package names should end with PACKAGE. - Enumeration literals should have suffixes

  12. AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XXIV, I--MAINTAINING THE FUEL SYSTEM PART III--CATERPILLAR DIESEL ENGINE, II--UNDERSTANDING THE VOLTAGE REGULATOR/ALTERNATOR.

    ERIC Educational Resources Information Center

    Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

    THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF THE DIESEL ENGINE FUEL AND BATTERY CHARGING SYSTEM. TOPICS ARE (1) INJECTION TIMING CONTROLS, (2) GOVERNOR, (3) FUEL SYSTEM MAINTENANCE TIPS, (4) THE CHARGING SYSTEM, (5) REGULATING THE GENERATOR/ALTERNATOR, AND (6) CHARGING SYSTEM SERVICE…

  13. Argentinean cultivars of Vitis vinifera grow better than European ones when cultured in vitro under salinity.

    PubMed

    Cavagnaro, Juan B; Ponce, María T; Guzmán, Javier; Cirrincione, Miguel A

    2006-04-01

    Argentinean Vitis vinifera cultivars although originated from Europe, have clear ampelographic and genotypic differences as compared with the European cultivars currently used in wine making. In vitro evaluation of salt tolerance has been used in many species. Our hypothesis was that Argentinean cultivars are more tolerant to salinity than European ones. Three European cultivars, Malbec, Cabernet Sauvignon and Chardonnay and four Argentincan cultivars, Cereza, Criolla Chica, Pedro Gimcnez and Torrontes Riojano were tested by in vitro culture. Treatments included: 1) Control, 2) 60 mEq/L of a mixture of three parts of NaCl and one part of CaCl2 and 3) 90 mEq/L of the salt mixture. Results from two experiments (I and II) are reported. No differences were found in plant survival, expressed as % of the respective control, among cultivars. Leaf area, leaf, stem and total dry matter (DM) in Experiment I and leaf area, leaf number and leaf, stem, root and total DM in Experiment II, were higher in Argentinean cultivars than in European ones. We conclude that Argentinean cultivars show better performance in growing under salinity, especially in the highest salt concentration. Differences among cultivars, inside each group, were found for most of the measured variables.

  14. [Phosphodiesterase inhibitors in clinical practice. The present and the future. Part II].

    PubMed

    Baksheev, B I; Kolomiets, N M

    2007-01-01

    Type Sphosphodiesterase inhibitors (FDEI-5) used to be applied as the main drugs for treatment of erectile dysfunction. At present, this pharmacological group is being studied intensively in various fields of clinical medicine, such as pulmonology, cardiology, gastroenterology, gynecology etc. Part II of this system literature review is dedicated to analysis of the results of such application. In many randomized and non-randomized controlled studies sildenafil decreased pulmonary arterial pressure (independently of etiology) and pulmonary vascular resistance; it could be successfully combined with nitric oxide, illoprost, or epoprostenolol. Clinical studies have also demonstrated an increase in physical load tolerance, optimization of PAH studies according to NYHA functional classes, and good tolerance to the drug. In the recent years, antiischaemic effects of FDEI-5 and their ability to inhibit apoptosis have been proved It is possible to draw the conclusion that nature created a universal phosphodiesterase mechanism for the interconnection of biochemical processes that provide the vital activity of the cell and organism. The fact that more than 15 controlled studies of clinical application of sildenafil not for treatment of erectile dysfunction have been planned and commenced confirms the importance of further studies of this mechanism. Further analysis of the results will show how universal this mechanism is.

  15. WavePacket: A Matlab package for numerical quantum dynamics.II: Open quantum systems, optimal control, and model reduction

    NASA Astrophysics Data System (ADS)

    Schmidt, Burkhard; Hartmann, Carsten

    2018-07-01

    WavePacket is an open-source program package for numeric simulations in quantum dynamics. It can solve time-independent or time-dependent linear Schrödinger and Liouville-von Neumann-equations in one or more dimensions. Also coupled equations can be treated, which allows, e.g., to simulate molecular quantum dynamics beyond the Born-Oppenheimer approximation. Optionally accounting for the interaction with external electric fields within the semi-classical dipole approximation, WavePacket can be used to simulate experiments involving tailored light pulses in photo-induced physics or chemistry. Being highly versatile and offering visualization of quantum dynamics 'on the fly', WavePacket is well suited for teaching or research projects in atomic, molecular and optical physics as well as in physical or theoretical chemistry. Building on the previous Part I [Comp. Phys. Comm. 213, 223-234 (2017)] which dealt with closed quantum systems and discrete variable representations, the present Part II focuses on the dynamics of open quantum systems, with Lindblad operators modeling dissipation and dephasing. This part also describes the WavePacket function for optimal control of quantum dynamics, building on rapid monotonically convergent iteration methods. Furthermore, two different approaches to dimension reduction implemented in WavePacket are documented here. In the first one, a balancing transformation based on the concepts of controllability and observability Gramians is used to identify states that are neither well controllable nor well observable. Those states are either truncated or averaged out. In the other approach, the H2-error for a given reduced dimensionality is minimized by H2 optimal model reduction techniques, utilizing a bilinear iterative rational Krylov algorithm. The present work describes the MATLAB version of WavePacket 5.3.0 which is hosted and further developed at the Sourceforge platform, where also extensive Wiki-documentation as well as numerous worked-out demonstration examples with animated graphics can be found.

  16. The year 2012 in the European Heart Journal-Cardiovascular Imaging. Part II.

    PubMed

    Plein, Sven; Knuuti, Juhani; Edvardsen, Thor; Saraste, Antti; Piérard, Luc A; Maurer, Gerald; Lancellotti, Patrizio

    2013-07-01

    The part II of the best of the European Heart Journal - Cardiovascular Imaging in 2012 specifically focuses on studies of valvular heart diseases, heart failure, cardiomyopathies, and congenital heart diseases.

  17. Methods of Responsibly Managing End-of-Life Foams and Plastics Containing Flame Retardants: Part II.

    PubMed

    Lucas, Donald; Petty, Sara M; Keen, Olya; Luedeka, Bob; Schlummer, Martin; Weber, Roland; Yazdani, Ramin; Riise, Brian; Rhodes, James; Nightingale, Dave; Diamond, Miriam L; Vijgen, John; Lindeman, Avery; Blum, Arlene; Koshland, Catherine P

    2018-06-01

    This is Part II of a review covering the wide range of issues associated with all aspects of the use and responsible disposal of foam and plastic wastes containing toxic or potentially toxic flame retardants. We identify basic and applied research needs in the areas of responsible collection, pretreatment, processing, and management of these wastes. In Part II, we explore alternative technologies for the management of halogenated flame retardant (HFR) containing wastes, including chemical, mechanical, and thermal processes for recycling, treatment, and disposal.

  18. Caring communications: how technology enhances interpersonal relations, Part II.

    PubMed

    Simpson, Roy L

    2008-01-01

    Part I of this 2-part series about technology's role in interpersonal communications examined how humans interact; proposed a caring theory of communication, collaboration, and conflict resolution; and delineated ways that technology--in general--supports this carative model of interpersonal relations. Part II will examine the barriers to adoption of carative technologies, describe the core capabilities required to overcome them, and discuss specific technologies that can support carative interpersonal relationships.

  19. A tensor analysis to evaluate the effect of high-pull headgear on Class II malocclusions.

    PubMed

    Ngan, P; Scheick, J; Florman, M

    1993-03-01

    The inaccuracies inherent in cephalometric analysis of treatment effects are well known. The objective of this article is to present a more reliable research tool in the analysis of cephalometric data. Bookstein introduced a dilation function by means of a homogeneous deformation tensor as a method of describing changes in cephalometric data. His article gave an analytic description of the deformation tensor that permits the rapid and highly accurate calculation of it on a desktop computer. The first part of this article describes the underlying ideas and mathematics. The second part uses the tensor analysis to analyze the cephalometric results of a group of patients treated with high-pull activator (HPA) to demonstrate the application of this research tool. Eight patients with Class II skeletal open bite malocclusions in the mixed dentition were treated with HPA. A control sample consisting of eight untreated children with Class II who were obtained from The Ohio State University Growth Study was used as a comparison group. Lateral cephalograms taken before and at the completion of treatment were traced, digitized, and analyzed with the conventional method and tensor analysis. The results showed that HPA had little or no effect on maxillary skeletal structures. However, reduction in growth rate was found with the skeletal triangle S-N-A, indicating a posterior tipping and torquing of the maxillary incisors. The treatment also induced additional deformation on the mandible in a downward and slightly forward direction. Together with the results from the conventional cephalometric analysis, HPA seemed to provide the vertical and rotational control of the maxilla during orthopedic Class II treatment by inhibiting the downward and forward eruptive path of the upper posterior teeth. The newly designed computer software permits rapid analysis of cephalometric data with the tensor analysis on a desktop computer. This tool may be useful in analyzing growth changes for research data.

  20. Simulation and experimental studies of operators` decision styles and crew composition while using an ecological and traditional user interface for the control room of a nuclear power plant

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meshkati, N.; Buller, B.J.; Azadeh, M.A.

    1995-04-01

    The goal of this research is threefold: (1) use of the Skill-, Rule-, and Knowledge-based levels of cognitive control -- the SRK framework -- to develop an integrated information processing conceptual framework (for integration of workstation, job, and team design); (2) to evaluate the user interface component of this framework -- the Ecological display; and (3) to analyze the effect of operators` individual information processing behavior and decision styles on handling plant disturbances plus their performance on, and preference for, Traditional and Ecological user interfaces. A series of studies were conducted. In Part I, a computer simulation model and amore » mathematical model were developed. In Part II, an experiment was designed and conducted at the EBR-II plant of the Argonne National Laboratory-West in Idaho Falls, Idaho. It is concluded that: the integrated SRK-based information processing model for control room operations is superior to the conventional rule-based model; operators` individual decision styles and the combination of their styles play a significant role in effective handling of nuclear power plant disturbances; use of the Ecological interface results in significantly more accurate event diagnosis and recall of various plant parameters, faster response to plant transients, and higher ratings of subject preference; and operators` decision styles affect on both their performance and preference for the Ecological interface.« less

  1. A Phase II/III randomized controlled trial comparing perioperative versus postoperative chemotherapy with mFOLFOX6 for lower rectal cancer with suspected lateral pelvic node metastasis: Japan Clinical Oncology Group Study JCOG1310 (PRECIOUS study).

    PubMed

    Ohue, Masayuki; Iwasa, Satoru; Kanemitsu, Yukihide; Hamaguchi, Tetsuya; Shiozawa, Manabu; Ito, Masaaki; Yasui, Masayoshi; Katayama, Hiroshi; Mizusawa, Junki; Shimada, Yasuhiro

    2017-01-01

    A randomized phase II/III trial was started in May 2015 comparing perioperative versus postoperative chemotherapy with modified infusional fluorouracil and folinic acid with oxaliplatin for lower rectal cancer patients with suspected lateral pelvic node metastasis. The standard arm is total mesorectal excision or tumor-specific mesorectal excision with lateral pelvic node dissection (LND) followed by postoperative chemotherapy (modified infusional fluorouracil and folinic acid with oxaliplatin; 12 cycles). The experimental (perioperative chemotherapy) arm is six courses of modified infusional fluorouracil and folinic acid with oxaliplatin before and six courses after total mesorectal excision with lateral pelvic node dissection. The aim of this trial is to confirm the superiority of perioperative chemotherapy. A total of 330 patients will be enrolled over 7 years. The primary endpoint in Phase II part is proportion of R0 resection and that in Phase III part is overall survival. Secondary endpoints are progression-free survival, local progression-free survival, etc. This trial has been registered in the UMIN Clinical Trials Registry as UMIN000017603 [http://www.umin.ac.jp/ctr/index-j.htm]. © The Author 2016. Published by Oxford University Press.

  2. Synthesis and Analgesic Properties of Lidocaine Derivatives with Substituted Aminobenzothiazoles.

    PubMed

    Ahmadi, Abbas; Khalili, Mohsen; Mohammadinoude, Mohammad Kazem; Nahri-Niknafs, Babak

    2016-01-01

    Local anesthetics are the most widely consumed drugs in the practice of medicine which provide a loss of sensation in a certain body part without loss of consciousness or impairment of central control of essential functions. Lidocaine (I) is the most commonly local anaesthetic drug which is widely used in all species due to its fabulous diffusing and penetrating properties as well as prompt onset of surgical analgesia. In this study, new aminobenzothiazole (with many useful biological and pharmacological properties) analogues were synthesized by changing of amine moiety of I. Both acute and chronic pain properties of new compounds (II-VI) were studied by using the tail immersion and formalin tests on mice and the outcomes were compared with control and lidocaine groups. According to the results, aminobenzothiazole derivatives are better candidates than diethylamine group for replacement on amine moiety of I. Also, derivatives with electron-withdrawing groups on this amine (V and VI) could decrease pain better than electron-donating ones (II and III) (specially on position 6 of this amine, II and V) which may be of concern for blockade of specific sodium channels by these new compounds.

  3. Kick, Glide, Pole! Cross-Country Skiing Fun (Part II)

    ERIC Educational Resources Information Center

    Duoos, Bridget A.

    2012-01-01

    Part I of Kick, Glide, Pole! Cross-Country Skiing Fun, which was published in last issue, discussed how to select cross-country ski equipment, dress for the activity and the biomechanics of the diagonal stride. Part II focuses on teaching the diagonal stride technique and begins with a progression of indoor activities. Incorporating this fun,…

  4. An Occupation and Participation Approach to Reading Intervention (OPARI) Part II: Pilot Clinical Application

    ERIC Educational Resources Information Center

    Grajo, Lenin C.; Candler, Catherine

    2016-01-01

    The Occupation and Participation Approach to Reading Intervention (OPARI) is an intervention approach for children with reading difficulties that emphasizes reading as an important occupation of children. Part I presented the theoretical basis of the OPARI. Part II describes a pilot clinical application of the OPARI. Guided by Schkade and…

  5. The prototype cameras for trans-Neptunian automatic occultation survey

    NASA Astrophysics Data System (ADS)

    Wang, Shiang-Yu; Ling, Hung-Hsu; Hu, Yen-Sang; Geary, John C.; Chang, Yin-Chang; Chen, Hsin-Yo; Amato, Stephen M.; Huang, Pin-Jie; Pratlong, Jerome; Szentgyorgyi, Andrew; Lehner, Matthew; Norton, Timothy; Jorden, Paul

    2016-08-01

    The Transneptunian Automated Occultation Survey (TAOS II) is a three robotic telescope project to detect the stellar occultation events generated by TransNeptunian Objects (TNOs). TAOS II project aims to monitor about 10000 stars simultaneously at 20Hz to enable statistically significant event rate. The TAOS II camera is designed to cover the 1.7 degrees diameter field of view of the 1.3m telescope with 10 mosaic 4.5k×2k CMOS sensors. The new CMOS sensor (CIS 113) has a back illumination thinned structure and high sensitivity to provide similar performance to that of the back-illumination thinned CCDs. Due to the requirements of high performance and high speed, the development of the new CMOS sensor is still in progress. Before the science arrays are delivered, a prototype camera is developed to help on the commissioning of the robotic telescope system. The prototype camera uses the small format e2v CIS 107 device but with the same dewar and also the similar control electronics as the TAOS II science camera. The sensors, mounted on a single Invar plate, are cooled to the operation temperature of about 200K as the science array by a cryogenic cooler. The Invar plate is connected to the dewar body through a supporting ring with three G10 bipods. The control electronics consists of analog part and a Xilinx FPGA based digital circuit. One FPGA is needed to control and process the signal from a CMOS sensor for 20Hz region of interests (ROI) readout.

  6. 76 FR 17781 - Guidance Under Section 1502; Amendment of Matching Rule for Certain Gains on Member Stock...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... for part 1 continues to read in part as follows: Authority: 26 U.S.C. 7805. * * * 0 Par. 2. Section 1.1502-13 is amended by revising paragraphs (c)(6)(ii)(C)(2) and (c)(6)(ii)(D)(1) to read as follows: Sec. 1.1502-13 Intercompany transactions. * * * * * (c) * * * (6) * * * (ii) * * * (C) * * * (2) Effect...

  7. Hepatoprotective effect of Leucophyllum frutescens on Wistar albino rats intoxicated with carbon tetrachloride.

    PubMed

    Balderas-Renteria, Isaías; Camacho-Corona, Maria Del Rayo; Carranza-Rosales, Pilar; Lozano-Garza, Hector G; Castillo-Nava, Dalila; Alvarez-Mendoza, Francisco J; Tamez-Cantú, Elsa M

    2007-01-01

    Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Leucophyllum frutescens to treat hepatic diseases. Protective action of L. frutescens methanol extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl(4)). Wistar albino rats were divided into five groups. Group I was normal control group; Groups II-V received CCl(4). After inducing hepatic damage, Group II served as control CCl(4); Group III was given silymarin as reference hepatoprotective; and Groups IV and V received different doses of plant extract. Liver marker enzymes were assayed in serum. Samples of livers were observed under microscope for the histopathological changes. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased significantly in CCl(4) treated rats (Group II). Groups IV and V intoxicated with CCl(4) and treated with L. frutescens methanol extract significant decreased the activities of these two enzymes. Also these groups resulted in less pronounced destruction of the liver architecture, there is not fibrosis and have moderate inflammation compared with Group II. The present study scientifically validated the traditional use of L. frutescens for liver disorders. In conclusion the methanol extract of L. frutescens aerial parts could be an important source of hepatoprotective compounds.

  8. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease.

    PubMed

    Sverdlov, Aaron L; Elezaby, Aly; Qin, Fuzhong; Behring, Jessica B; Luptak, Ivan; Calamaras, Timothy D; Siwik, Deborah A; Miller, Edward J; Liesa, Marc; Shirihai, Orian S; Pimentel, David R; Cohen, Richard A; Bachschmid, Markus M; Colucci, Wilson S

    2016-01-11

    Mitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. Mice fed a high-fat high-sucrose (HFHS) diet develop MHD with cardiac diastolic and mitochondrial dysfunction that is associated with oxidative posttranslational modifications of cardiac mitochondrial proteins. Transgenic mice that express catalase in mitochondria and wild-type mice were fed an HFHS or control diet for 4 months. Cardiac mitochondria from HFHS-fed wild-type mice had a 3-fold greater rate of H2O2 production (P=0.001 versus control diet fed), a 30% decrease in complex II substrate-driven oxygen consumption (P=0.006), 21% to 23% decreases in complex I and II substrate-driven ATP synthesis (P=0.01), and a 62% decrease in complex II activity (P=0.002). In transgenic mice that express catalase in mitochondria, all HFHS diet-induced mitochondrial abnormalities were ameliorated, as were left ventricular hypertrophy and diastolic dysfunction. In HFHS-fed wild-type mice complex II substrate-driven ATP synthesis and activity were restored ex vivo by dithiothreitol (5 mmol/L), suggesting a role for reversible cysteine oxidative posttranslational modifications. In vitro site-directed mutation of complex II subunit B Cys100 or Cys103 to redox-insensitive serines prevented complex II dysfunction induced by ROS or high glucose/high palmitate in the medium. Mitochondrial ROS are pathogenic in MHD and contribute to mitochondrial dysfunction, at least in part, by causing oxidative posttranslational modifications of complex I and II proteins including reversible oxidative posttranslational modifications of complex II subunit B Cys100 and Cys103. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  9. Evodiamine Inhibits Angiotensin II-Induced Rat Cardiomyocyte Hypertrophy.

    PubMed

    He, Na; Gong, Qi-Hai; Zhang, Feng; Zhang, Jing-Yi; Lin, Shu-Xian; Hou, Hua-Hua; Wu, Qin; Sun, An-Sheng

    2018-05-01

    To investigate the effects of evodiamine (Evo), a component of Evodiaminedia rutaecarpa (Juss.) Benth, on cardiomyocyte hypertrophy induced by angiotensin II (Ang II) and further explore the potential mechanisms. Cardiomyocytes from neonatal Sprague Dawley rats were isolated and characterized, and then the cadiomyocyte cultures were randomly divided into control, model (Ang II 0.1 μmol/L), and Evo (0.03, 0.3, 3 μmol/L) groups. The cardiomyocyte surface area, protein level, intracellular free calcium ([Ca 2+ ] i ) concentration, activity of nitric oxide synthase (NOS) and content of nitric oxide (NO) were measured, respectively. The mRNA expressions of atrial natriuretic factor (ANF), calcineurin (CaN), extracellular signal-regulated kinase-2 (ERK-2), and endothelial nitric oxide synthase (eNOS) of cardiomyocytes were analyzed by real-time reverse transcriptionpolymerase chain reaction. The protein expressions of calcineurin catalytic subunit (CnA) and mitogen-activated protein kinase phosphatase-1 (MKP-1) were detected by Western blot analysis. Compared with the control group, Ang II induced cardiomyocytes hypertrophy, as evidenced by increased cardiomyocyte surface area, protein content, and ANF mRNA expression; increased intracellular free calcium ([Ca 2+ ] i ) concentration and expressions of CaN mRNA, CnA protein, and ERK-2 mRNA, but decreased MKP-1 protein expression (P<0.05 or P<0.01). Compared with Ang II, Evo (0.3, 3 μmol/L) significantly attenuated Ang II-induced cardiomyocyte hypertrophy, decreased the [Ca 2+ ] i concentration and expressions of CaN mRNA, CnA protein, and ERK-2 mRNA, but increased MKP-1 protein expression (P<0.05 or P<0.01). Most interestingly, Evo increased the NOS activity and NO production, and upregulated the eNOS mRNA expression (P<0.05). Evo signifificantly attenuated Ang II-induced cardiomyocyte hypertrophy, and this effect was partly due to promotion of NO production, reduction of [Ca 2+ ]i concentration, and inhibition of CaN and ERK-2 signal transduction pathways.

  10. Corporate liability: security and violence--Part II.

    PubMed

    Fiesta, J

    1996-04-01

    A hospital can be held liable for injuries resulting from failure to provide adequate, reasonable security Part II of "corporate Liability: Security and Violence" addresses negligent hiring and supervision practices, injury and domestic violence in the workplace and communication procedures.

  11. Fourier Transform Infrared Spectroscopy: Part II. Advantages of FT-IR.

    ERIC Educational Resources Information Center

    Perkins, W. D.

    1987-01-01

    This is Part II in a series on Fourier transform infrared spectroscopy (FT-IR). Described are various advantages of FT-IR spectroscopy including energy advantages, wavenumber accuracy, constant resolution, polarization effects, and stepping at grating changes. (RH)

  12. Critical dosimetry measures and surrogate tools that can facilitate clinical success in PDT (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Pogue, Brian W.; Davis, Scott C.; Kanick, Stephen C.; Maytin, Edward V.; Pereira, Stephen P.; Palanisami, Akilan; Hasan, Tayyaba

    2016-03-01

    Photodynamic therapy can be a highly complex treatment with more than one parameter to control, or in some cases it is easily implemented with little control other than prescribed drug and light values. The role of measured dosimetry as related to clinical adoption has not been as successful as it could have been, and part of this may be from the conflicting goals of advocating for as many measurements as possible for accurate control, versus companies and clinical adopters advocating for as few measurements as possible, to keep it simple. An organized approach to dosimetry selection is required, which shifts from mechanistic measurements in pre-clinical and early phase I trials, towards just those essential dose limiting measurements and a focus on possible surrogate measures in phase II/III trials. This essential and surrogate approach to dosimetry should help successful adoption of clinical PDT if successful. The examples of essential dosimetry points and surrogate dosimetry tools which might be implemented in phase II and higher trials are discussed for solid tissue PDT with verteporfin and skin lesion treatment with aminolevulinc acid.

  13. Improving Quality of Seal Leak Test Product using Six Sigma

    NASA Astrophysics Data System (ADS)

    Luthfi Malik, Abdullah; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Seal leak test part is a polyurethane material-based product. Based on past data, defect level of this product was 8%, higher than the target of 5%. Quality improvement effort was done using six sigma method that included phases of define, measure, analyse, improve, and control. In the design phase, a Delphi method was used to identify factors that were critical to quality. In the measure phase, stability and process capability was measured. Fault tree analysis (FTA) and failure mode and effect analysis (FMEA) were used in the next phase to analize the root cause and to determine the priority issues. Improve phase was done by compiling, selecting, and designing alternative repair. Some improvement efforts were identified, i.e. (i) making a checklist for maintenance schedules, (ii) making written reminder form, (iii) modifying the SOP more detail, and (iv) performing a major service to the vacuum machine. To ensure the continuity of improvement efforts, some control activities were executed, i.e. (i) controlling, monitoring, documenting, and setting target frequently, (ii) implementing reward and punishment system, (iii) adding cleaning tool, and (iv) building six sigma organizational structure.

  14. Sporting Goods. Part I: Hunting and Fishing Equipment and Part II: Athletic, Marine, and Camping Equipment. A Distributive Education Manual.

    ERIC Educational Resources Information Center

    Day, Bill D., Comp.

    These manuals were prepared to introduce students to the fundamentals of hunting and fishing (Part I) and sports requiring athletic, marine and camping equipment (Part II). The sports salesman is in the position of offering a service to the customer, and he can best do so by understanding the sports and the variety of products which may be sold to…

  15. Interactive Macroeconomics

    NASA Astrophysics Data System (ADS)

    Di Guilmi, Corrado; Gallegati, Mauro; Landini, Simone

    2017-04-01

    Preface; List of tables; List of figures, 1. Introduction; Part I. Methodological Notes and Tools: 2. The state space notion; 3. The master equation; Part II. Applications to HIA Based Models: 4. Financial fragility and macroeconomic dynamics I: heterogeneity and interaction; 5. Financial fragility and macroeconomic Dynamics II: learning; Part III. Conclusions: 6. Conclusive remarks; Part IV. Appendices and Complements: Appendix A: Complements to Chapter 3; Appendix B: Solving the ME to solve the ABM; Appendix C: Specifying transition rates; Index.

  16. Design of two-dimensional channels with prescribed velocity distributions along the channel walls

    NASA Technical Reports Server (NTRS)

    Stanitz, John D

    1953-01-01

    A general method of design is developed for two-dimensional unbranched channels with prescribed velocities as a function of arc length along the channel walls. The method is developed for both compressible and incompressible, irrotational, nonviscous flow and applies to the design of elbows, diffusers, nozzles, and so forth. In part I solutions are obtained by relaxation methods; in part II solutions are obtained by a Green's function. Five numerical examples are given in part I including three elbow designs with the same prescribed velocity as a function of arc length along the channel walls but with incompressible, linearized compressible, and compressible flow. One numerical example is presented in part II for an accelerating elbow with linearized compressible flow, and the time required for the solution by a Green's function in part II was considerably less than the time required for the same solution by relaxation methods in part I.

  17. Ada Integrated Environment II Computer Program Development Specification. Part 1.

    DTIC Science & Technology

    1981-12-01

    34Programmable" access 3.2.5.5 controls ; provision for privileged 3.2.5.6 user. 3.3.1 3.3.3 4.1.2.11 3.7.1.2 KDBS - 3.2.5.7 Capability to archive data base...CM -1 1 PHASE I SOW REQUIREMENTS A - SPEC B5 -SPEC 4.111. 3.7.2 1Compiler -331 aMAPSE shall include a mechanism for 1 Linker -3.2.5 aautomatic stub...19 3.2.5.5 Process Administrator The Process Administrator controls the executions of logically concurrent MAPSE processes. The KFW Interface Package

  18. Small Body GN&C Research Report: A Robust Model Predictive Control Algorithm with Guaranteed Resolvability

    NASA Technical Reports Server (NTRS)

    Acikmese, Behcet A.; Carson, John M., III

    2005-01-01

    A robustly stabilizing MPC (model predictive control) algorithm for uncertain nonlinear systems is developed that guarantees the resolvability of the associated finite-horizon optimal control problem in a receding-horizon implementation. The control consists of two components; (i) feedforward, and (ii) feedback part. Feed-forward control is obtained by online solution of a finite-horizon optimal control problem for the nominal system dynamics. The feedback control policy is designed off-line based on a bound on the uncertainty in the system model. The entire controller is shown to be robustly stabilizing with a region of attraction composed of initial states for which the finite-horizon optimal control problem is feasible. The controller design for this algorithm is demonstrated on a class of systems with uncertain nonlinear terms that have norm-bounded derivatives, and derivatives in polytopes. An illustrative numerical example is also provided.

  19. A robust model predictive control algorithm for uncertain nonlinear systems that guarantees resolvability

    NASA Technical Reports Server (NTRS)

    Acikmese, Ahmet Behcet; Carson, John M., III

    2006-01-01

    A robustly stabilizing MPC (model predictive control) algorithm for uncertain nonlinear systems is developed that guarantees resolvability. With resolvability, initial feasibility of the finite-horizon optimal control problem implies future feasibility in a receding-horizon framework. The control consists of two components; (i) feed-forward, and (ii) feedback part. Feed-forward control is obtained by online solution of a finite-horizon optimal control problem for the nominal system dynamics. The feedback control policy is designed off-line based on a bound on the uncertainty in the system model. The entire controller is shown to be robustly stabilizing with a region of attraction composed of initial states for which the finite-horizon optimal control problem is feasible. The controller design for this algorithm is demonstrated on a class of systems with uncertain nonlinear terms that have norm-bounded derivatives and derivatives in polytopes. An illustrative numerical example is also provided.

  20. A Model-based B2B (Batch to Batch) Control for An Industrial Batch Polymerization Process

    NASA Astrophysics Data System (ADS)

    Ogawa, Morimasa

    This paper describes overview of a model-based B2B (batch to batch) control for an industrial batch polymerization process. In order to control the reaction temperature precisely, several methods based on the rigorous process dynamics model are employed at all design stage of the B2B control, such as modeling and parameter estimation of the reaction kinetics which is one of the important part of the process dynamics model. The designed B2B control consists of the gain scheduled I-PD/II2-PD control (I-PD with double integral control), the feed-forward compensation at the batch start time, and the model adaptation utilizing the results of the last batch operation. Throughout the actual batch operations, the B2B control provides superior control performance compared with that of conventional control methods.

  1. Angiotensin II activates collagen type I gene in the renal vasculature of transgenic mice during inhibition of nitric oxide synthesis: evidence for an endothelin-mediated mechanism.

    PubMed

    Boffa, J J; Tharaux, P L; Placier, S; Ardaillou, R; Dussaule, J C; Chatziantoniou, C

    1999-11-02

    Hypertension is frequently associated with renal vascular fibrosis. The purpose of this study was to investigate whether angiotensin II (Ang II) is involved in this fibrogenic process. Experiments were performed on transgenic mice harboring the luciferase gene under the control of the collagen I-alpha(2) chain promoter [procolalpha(2)(I)]. Hypertension was induced by chronic inhibition of NO synthesis (N(G)-nitro-L-arginine methyl ester, L-NAME). Procolalpha(2)(I) activity started to increase in the renal vasculature after 4 weeks of L-NAME treatment (P<0.01) and at 14 weeks reached 3- and 8-fold increases over control in afferent arterioles and glomeruli, respectively (P<0.001). Losartan, an AT(1) receptor antagonist, given simultaneously with L-NAME prevented the increase of procolalpha(2)(I) levels and attenuated the development of renal vascular fibrosis without normalizing systolic pressure increase. Because we found previously that endothelin mediated renal vascular fibrosis in the L-NAME model, the interaction between Ang II, endothelin, and procolalpha(2)(I) was investigated in ex vivo and short-term in vivo experiments. In both conditions, the Ang II-induced activation of procolalpha(2)(I) in renal cortex was blocked by an endothelin receptor antagonist. During chronic inhibition of NO, the collagen I gene becomes activated, leading to the development of renal vascular fibrosis. Ang II is a major player in this fibrogenic process, and its effect on collagen I gene is independent of systemic hemodynamics and is at least partly mediated by the profibrogenic action of endothelin.

  2. Adherence therapy improves medication adherence and quality of life in people with Parkinson's disease: a randomised controlled trial.

    PubMed

    Daley, D J; Deane, K H O; Gray, R J; Clark, A B; Pfeil, M; Sabanathan, K; Worth, P F; Myint, P K

    2014-08-01

    Many factors are associated with medication non-adherence in Parkinson's disease (PD), including complex treatment regimens, mood disorders and impaired cognition. However, interventions to improve adherence which acknowledge such factors are lacking. A phase II randomised controlled trial was conducted investigating whether Adherence Therapy (AT) improves medication adherence and quality of life (QoL) compared with routine care (RC) in PD. Eligible PD patients and their spouse/carers were randomised to intervention (RC plus AT) or control (RC alone). Primary outcomes were change in adherence (Morisky Medication Adherence Scale) and QoL (Parkinson's Disease Questionnaire-39) from baseline to week-12 follow up. Secondary outcomes were MDS-UPDRS (part I, II, IV), Beliefs about Medication Questionnaire (BMQ), EuroQol (EQ-5D) and the Caregiving Distress Scale. Blinded data were analysed using logistic and linear regression models based on the intention-to-treat principle. Seventy-six patients and 46 spouse/carers completed the study (intervention: n = 38 patients, n = 24 spouse/carers). At week-12 AT significantly improved adherence compared with RC (OR 8.2; 95% CI: 2.8, 24.3). Numbers needed to treat (NNT) were 2.2 (CI: 1.6, 3.9). Compared with RC, AT significantly improved PDQ-39 (-9.0 CI: -12.2, -5.8), BMQ general harm (-1.0 CI: -1.9, -0.2) and MDS-UPDRS part II (-4.8 CI: -8.1, -1.4). No significant interaction was observed between the presence of a spouse/carer and the effect of AT. Adherence Therapy improved self-reported adherence and QoL in a PD sample. The small NNT suggests AT may be cost-effective. A larger pragmatic trial to test the efficacy and cost-effectiveness of AT by multiple therapists is required. © 2014 John Wiley & Sons Ltd.

  3. Status of Centrifugal Impeller Internal Aerodynamics: Experiments and Calculations

    DTIC Science & Technology

    1979-02-01

    Dan Adler February 1979 TJ Approved for public release; distribution unlimited 267.5 16 Prepared for: A35 Naval Air Systems Command Washington...The work reported herein was supported by the Naval Air Systems Command, Washington, DC. Reproduction of all or part of this report is authorized...6115 3N; N00019-79-WR-91115 II. CONTROLLING OFFICE NAME AND ADDRESS Naval Air Systems Command Washington, DC 20361 12. REPORT DATE

  4. Demonstration Testing of Plastic Media Blasting (PMB) at LetterKenny Army Depot.

    DTIC Science & Technology

    1989-01-10

    media can typically be purchased in three grades; Type I (polyester), Type II ( urea formaldehyde ), and Type III ( melamine formaldehyde ). The hardness of...outlet for waste thermoset resin from button making operations. As plastic media is synthetic, the~properties of plastic oedia can be controlled to a...After the oven comes to temperature, the parts are heated for an appropriate time, usually several hours, to pyrolyze the organic resin coating. The

  5. Marine Air Traffic Control and Landing System (METCALS) Investigation.

    DTIC Science & Technology

    1982-02-01

    as Identification Friend-or-Foe (IFF), was first developed and used by the military in World War II. Since then, IFF has been expanded and improved... identification and three dimensional target position accuracy. In addition, because this system employs a transponder, the signal strength loss with range... identification . The first two events can be used to state the MATCALS ASR operational goal in radar terms. This statement consists of two parts: (1

  6. [Resistant starches. Part II. Physico-chemical and technological aspects solution medico-biological problems].

    PubMed

    Iur'ev, V P; Gapparov, M M; Vasserman, L A; Genkina, N K

    2006-01-01

    This paper is a review of the recent literature data related to structure, composition and physico-chemical properties of starches as well as the special methods of processing of the starch containing raw sources producing the food products with increasing content of resistant starches. The prognosis is made about usefulness of such resistant starches for control of some metabolic disorder in human organism and for prophylactic aims.

  7. Conduct and Accountability; A Report to the President.

    DTIC Science & Technology

    1986-06-01

    developments ats passage o)fthe E~thics in] () % I I ertI eitI cto I f19 7 8. F venI inII’ Ir its cret v ers1 in , D I re c t Ive 550O. 7 1) rovId(Ie s milly...part, that, ’The Plant Rep/ACO is the team contractors’ policies, procedures, manager for all PCO requests for field pric ing controls, and practices

  8. Managing emergencies and abnormal situations in air traffic control (part II): teamwork strategies.

    PubMed

    Malakis, Stathis; Kontogiannis, Tom; Kirwan, Barry

    2010-07-01

    Team performance has been studied in many safety-critical organizations including aviation, nuclear power plant, offshore oil platforms and health organizations. This study looks into teamwork strategies that air traffic controllers employ to manage emergencies and abnormal situations. Two field studies were carried out in the form of observations of simulator training in emergency and unusual scenarios of novices and experienced controllers. Teamwork strategies covered aspects of team orientation and coordination, information exchange, change management and error handling. Several performance metrics were used to rate the efficiency of teamwork and test the construct validity of a prototype model of teamwork. This is a companion study to an earlier investigation of taskwork strategies in the same field (part I) and contributes to the development of a generic model for Taskwork and Teamwork strategies in Emergencies in Air traffic Management (T(2)EAM). Suggestions are made on how to use T(2)EAM to develop training programs, assess team performance and improve mishap investigations. Copyright 2010 Elsevier Ltd. All rights reserved.

  9. 40 CFR Appendix II to Part 257 - Appendix II to Part 257

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

  10. 40 CFR Appendix II to Part 257 - Appendix II to Part 257

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

  11. 40 CFR Appendix II to Part 257 - Appendix II to Part 257

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

  12. 40 CFR Appendix II to Part 257 - Appendix II to Part 257

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

  13. 40 CFR Appendix II to Part 257 - Appendix II to Part 257

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... are only add-on in nature. Beta ray irradiation: Sludge is irradiated with beta rays from an accelerator at dosages of at least 1.0 megarad at room temperature (ca. 20 °C). Gamma ray irradiation: Sludge...

  14. The Mental Health Recovery Movement and Family Therapy, Part II: A Collaborative, Appreciative Approach for Supporting Mental Health Recovery

    ERIC Educational Resources Information Center

    Gehart, Diane R.

    2012-01-01

    A continuation of Part I, which introduced mental health recovery concepts to family therapists, Part II of this article outlines a collaborative, appreciative approach for working in recovery-oriented contexts. This approach draws primarily upon postmodern therapies, which have numerous social justice and strength-based practices that are easily…

  15. Institutional Self-Analysis and Long-Range Planning in a Small Liberal Arts College. Part II-- Study Procedure.

    ERIC Educational Resources Information Center

    Frame, Stanley M.

    In the Spring of 1969, Bethany Nazarene College started an intensive self evaluation effort, called the Ten-Year Advance Study. Part I of the report, the Study Design, was published in October 1969. This study, Part II, relates the study activities, the methodology, and sources consulted. The effort involved over 120 administrators, faculty,…

  16. Learning To Read with Private Pete & Sailor Sam in World War II.

    ERIC Educational Resources Information Center

    Sticht, Thomas G.

    Since thousands of the men who entered military service during World War II were illiterate, the Army developed an "Army Reader," a four-part series featuring Private Pete, that led learners through literacy levels 1-4. Part 1 introduced Private Pete and talked about the things the men experienced when they entered the Army. Part 2…

  17. An exploratory study of live vs. web-based delivery of a phlebotomy program.

    PubMed

    Fydryszewski, Nadine A; Scanlan, Craig; Guiles, H Jesse; Tucker, Ann

    2010-01-01

    Changes in student population and increased Web-based education offerings provided the impetus to assess pedagogy, cognitive outcomes and perceptions of course quality. This study explored cognitive outcomes and students' perception of course quality related to the Seven Principles for Good Practice in Undergraduate Education between live classroom delivery, compared to a Web-based delivery of a phlebotomy program. Quasi-experimental; students self-selected to enroll in live or Web-based program. For cognitive outcomes, no significant difference was found between the groups. Student perception of course quality differed only for Principle One (student-instructor contact). Students in the live classroom rated Principle One higher for the Part I course compared to the Web-based group. For the Part II course, there was no significant difference in perception of course quality related to any of the Seven Principles. The more constructivist pedagogy in the Part II course did not improve cognitive outcomes however, it may have contributed to knowledge retention. The live group rated Principle One in the Part II course evaluation relatively the same as they did for the Part I course evaluation. However, the Web-based group rated Principle One considerable higher for the Part II course than for Part I course. Future studies with a larger sample could explore improved course quality assessment instruments.

  18. Nonthermal Inactivation of Cronobacter sakazakii in Infant Formula Milk: A Review.

    PubMed

    Pina-Pérez, M C; Rodrigo, D; Martínez, A

    2016-07-26

    Up-to-date, nonthermal technologies and combinations of them, in accordance with the "hurdle technology" concept, are being applied by different research groups in response to calls by the International Food and Human Health Organizations (ESPGHAN, 2004; FAO/WHO, 2006, 2008) for alternatives to thermal control of Cronobacter sakazakii in reconstituted powdered infant formula milk. This review highlights (i) current knowledge on the application of nonthermal technologies to control C. sakazakii in infant formula milk and (ii) the importance of the application of nonthermal technologies for the control of C. sakazakii as part of the development of strategies in the context of improving food safety and quality of this product.

  19. Large-Scale Operations Management Test of Use of the White Amur for Control of Problem Aquatic Plants. Report 2. First Year Poststocking Results. Volume IV. Nitrogen and Phosphorus Dynamics of the Lake Conway Ecosystem: Loading Budgets and a Dynamic Hydrologic Phosphorus Model.

    DTIC Science & Technology

    1982-08-01

    AD-AIA 700 FLORIDA UN1V GAINESVILLE DEPT OF ENVIRONMENTAL ENGIN -ETC F/G 6/6 LARGE-SCALE OPERATIONS MANAGEMENT TEST OF USE OF THE WHITE AMOR--ENL...Conway ecosystem and is part of the Large- Scale Operations Management Test (LSOMT) of the Aquatic Plant Control Research Program (APCRP) at the WES...should be cited as follows: Blancher, E. C., II, and Fellows, C. R. 1982. "Large-Scale Operations Management Test of Use of the White Amur for Control

  20. The bipolar II disorder personality traits, a true syndrome?

    PubMed

    Gudmundsson, Einar

    2015-06-01

    The author was struck by the similarities and commonality of complaints, aside from mood swings, made by Bipolar II patients and started registrating these complaints. This registrational work eventually led to the development of The Bipolar II Syndome Checklist. The aim of this work was to understand how widely the Bipolar II disorder affects the personality, and what disturbing personality traits are the most common? Deliberately, no attempt was made to diagnose psychiatric comorbidities, in the hope that one would get a clearer view of what symptoms, if any, could be considered a natural part of the Bipolar II Disorder. As far as the author knows this is a novel approach. 105 Bipolar II patients completed the Bipolar II Syndrome Checklist. The answers to the 44 questions on the list are presented in tables. Symptoms like anxiety, low self esteem, paranoia, extreme hurtfulness, migraine, Post Partum Depression, obsessive traits, alcoholism in the family are amongst the findings which will be presented in greater detail. No control group. Bipolar I patients excluded. The Bipolar II Syndrome Checklist has not been systematically validated. The results show that Bipolar II Disorder causes multiple symptoms so commonly that it may be justified to describe it as a syndrome, The Bipolar II Syndrome. Also these disturbances commonly lie in families of Bipolar II patients and are in all likelihood, greatly underdiagnosed. The clinical relevance of this study lies in increasing our knowledge and understanding of the nature of the Bipolar II Disorder, which in all probability will increase the diagnostic and treatment accuracy, since clinicians are more likely to scan for other symptoms needing treatment. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Verbal and Visual Memory Impairments in Bipolar I and II Disorder.

    PubMed

    Ha, Tae Hyon; Kim, Ji Sun; Chang, Jae Seung; Oh, Sung Hee; Her, Ju Young; Cho, Hyun Sang; Park, Tae Sung; Shin, Soon Young; Ha, Kyooseob

    2012-12-01

    To compare verbal and visual memory performances between patients with bipolar I disorder (BD I) and patients with bipolar II disorder (BD II) and to determine whether memory deficits were mediated by impaired organizational strategies. Performances on the Korean-California Verbal Learning Test (K-CVLT) and the Rey-Osterrieth Complex Figure Test (ROCF) in 37 patients with BD I, 46 patients with BD II and 42 healthy subjects were compared. Mediating effects of impaired organization strategies on poor delayed recall was tested by comparing direct and mediated models using multiple regression analysis. Both patients groups recalled fewer words and figure components and showed lower Semantic Clustering compared to controls. Verbal memory impairment was partly mediated by difficulties in Semantic Clustering in both subtypes, whereas the mediating effect of Organization deficit on the visual memory impairment was present only in BD I. In all mediated models, group differences in delayed recall remained significant. Our findings suggest that memory impairment may be one of the fundamental cognitive deficits in bipolar disorders and that executive dysfunctions can exert an additional influence on memory impairments.

  2. Matematicas Para El Primer Ciclo Secundario, Volumen II (Parte 2). Traduccion Preliminar de la Edicion en Ingles Revisada. (Mathematics for Junior High School, Volume II, Part 2. Preliminary Translation of the Revised English Edition).

    ERIC Educational Resources Information Center

    Anderson, R. D.; And Others

    This is part two of a two-part SMSG mathematics text for junior high school students. Key ideas emphasized are structure of arithmetic from an algebraic viewpoint, the real number system as a progressing development, and metric and non-metric relations in geometry. Chapter topics include real numbers, similar triangles, variation, polyhedrons,…

  3. Application for certification for 1979 model year for light-duty vehicles - Audi

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    Every year, each manufacturer of passenger cars, light-duty trucks, motorcycles or heavy-duty engines submits to EPA an application for certification. The application consists of two parts. In the part I, the manufacturer gives a detailed technical description of the vehicles or engines he intends to market during the upcoming model year. These engineering data include explanations and/or drawings which describe engine/vehicle parameters such as basic engine design, fuel systems, ignition systems and exhaust and evaporative emission control systems. The part I also provides information on emission test procedures, service accumulation procedures, fuels to be used, and proposed maintenance requirements tomore » be followed during testing. The part II application submitted after emission testing is completed, contains the results of emission testing, a statement of compliance to the regulations, and maintenance instructions to be followed by the ultimate owners of the vehicles.« less

  4. Application for certification for 1979 model year for light-duty vehicles - Peugeot

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    Every year, each manufacturer of passenger cars, light-duty trucks, motorcycles or heavy-duty engines submits to EPA an application for certification. The application consists of two parts. In the part I, the manufacturer gives a detailed technical description of the vehicles or engines he intends to market during the upcoming model year. These engineering data include explanations and/or drawings which describe engine/vehicle parameters such as basic engine design, fuel systems, ignition systems and exhaust and evaporative emission control systems. The part I also provides information on emission test procedures, service accumulation procedures, fuels to be used, and proposed maintenance requirements tomore » be followed during testing. The part II application, submitted after emission testing is completed, contains the results of emission testing, a statement of compliance to the regulations, and maintenance instructions to be followed by the ultimate owners of the vehicles.« less

  5. Actualizing system benefits--Part II.

    PubMed

    Zinn, T K; DiGiulio, L W

    1988-05-01

    Do benefits impact the psychology of the information system buying decision? Is system success tied to achieving "promoted" benefits? Part II of this series reveals responses from a survey of some 3,000 executives about the importance of qualitative and quantitative benefits in the "buying process."

  6. Virtual sensors for active noise control in acoustic-structural coupled enclosures using structural sensing: part II--Optimization of structural sensor placement.

    PubMed

    Halim, Dunant; Cheng, Li; Su, Zhongqing

    2011-04-01

    The work proposed an optimization approach for structural sensor placement to improve the performance of vibro-acoustic virtual sensor for active noise control applications. The vibro-acoustic virtual sensor was designed to estimate the interior sound pressure of an acoustic-structural coupled enclosure using structural sensors. A spectral-spatial performance metric was proposed, which was used to quantify the averaged structural sensor output energy of a vibro-acoustic system excited by a spatially varying point source. It was shown that (i) the overall virtual sensing error energy was contributed additively by the modal virtual sensing error and the measurement noise energy; (ii) each of the modal virtual sensing error system was contributed by both the modal observability levels for the structural sensing and the target acoustic virtual sensing; and further (iii) the strength of each modal observability level was influenced by the modal coupling and resonance frequencies of the associated uncoupled structural/cavity modes. An optimal design of structural sensor placement was proposed to achieve sufficiently high modal observability levels for certain important panel- and cavity-controlled modes. Numerical analysis on a panel-cavity system demonstrated the importance of structural sensor placement on virtual sensing and active noise control performance, particularly for cavity-controlled modes.

  7. The study and design of tension controller

    NASA Astrophysics Data System (ADS)

    Jun, G.; Lamei, X.

    2018-02-01

    Tension control is a wide used technology in areas such as textiles, paper and plastic films. In this article, the tension control system release and winding process is analyzed and the mathematical model of tension control system is established, and a high performance tension controller is designed. In hardware design, STM32F130 single chip microcomputer is used as the control core, which has the characteristics of fast running speed and rich peripheral features. In software design, μC/OS-II operating system is introduced to improve the efficiency of single chip microcomputer, and enhance the independence of each module, and make development and maintenance more convenient. The taper tension control is adopted in the winding part, which can effectively solve the problem of rolling shrinkage. The results show that the tension controller has the characteristics of simple structure, easy operation and stable performance.

  8. Revised Olweus Bully/Victim Questionnaire: evaluation in visually impaired.

    PubMed

    Gothwal, Vijaya K; Sumalini, Rebecca; Irfan, Shaik Mohammad; Giridhar, Avula; Bharani, Seelam

    2013-08-01

    To explore the psychometric properties of the revised Olweus Bully/Victim Questionnaire (OBVQ) in children with visual impairment (VI) using Rasch analysis. One hundred fifty Indian children with VI between 8 and 16 years (mean age, 11.6 years; 69% male; mean acuity in the better eye of 0.80 logMAR [Snellen, 20/126]) were administered the revised OBVQ. The 40-item revised OBVQ was developed to assess victimization (i.e., being bullied) and bullying (bullying others) in normally sighted schoolchildren. Only 16 items are used for Rasch analysis and are divided into two parts: I (victimization, eight items) and II (bullying others, eight items). Separate Rasch analysis was conducted for both parts, and the psychometric properties investigated included behavior of rating scale, extent to which the items measured a single construct (unidimensionality by fit statistics and principal component analysis [PCA] of residuals); ability to discriminate among participants' victimization and bullying behaviors (measurement precision as assessed by person separation reliability [PSR] minimum recommended value, 0.80); and targeting of items to participants' victimization and bullying. Response categories were misused for both parts I and II, which required repair before further analysis. Measurement precision was inadequate for both parts (PSR, 0.64 for part I and 0.19 for part II), indicating poor discriminatory ability. All items fit the Rasch model well in part I, indicating unidimensionality that was further confirmed using PCA of residuals. However, an item misfit in part II that required deletion following which the remaining items fit and PCA of residuals also supported unidimensionality. Targeting was -0.58 logits for part I, indicating that the items were matched well with the participants' victimization. By comparison, targeting was suboptimal for part II (-1.97 logits). In its current state, the revised OBVQ is not a valid psychometric instrument to assess victimization and bullying among children with VI.

  9. AUTOMOTIVE DIESEL MAINTENANCE L. UNIT XII, PART I--MAINTAINING THE FUEL SYSTEM (PART II), CUMMINS DIESEL ENGINE, PART II--UNIT INSTALLATION (ENGINE).

    ERIC Educational Resources Information Center

    Human Engineering Inst., Cleveland, OH.

    THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATION AND MAINTENANCE OF THE DIESEL ENGINE FUEL SYSTEM AND THE PROCEDURES FOR DIESEL ENGINE INSTALLATION. TOPICS ARE FUEL FLOW CHARACTERISTICS, PTG FUEL PUMP, PREPARATION FOR INSTALLATION, AND INSTALLING ENGINE. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL BRANCH…

  10. Literacy and Deaf Students in Taiwan: Issues, Practices and Directions for Future Research--Part II

    ERIC Educational Resources Information Center

    Liu, Hsiu Tan; Andrews, Jean F.; Liu, Chun Jung

    2014-01-01

    In Part I, we underscore the issues surrounding young deaf and hard of hearing (DHH) learners of literacy in Taiwan who use sign to support their learning of Chinese literacy. We also described the linguistic features of Chinese writing and the visual codes used by DHH children. In Part II, we describe the reading and writing practices used with…

  11. The Hungarian congenital malformation monitoring system.

    PubMed

    Czeizel, A

    1978-01-01

    The Hungarian Congenital Malformation Monitor has been operating since 1973 in order to detect the temporal and regional clusters of 12 indicator congenital malformations as early as possible. This Monitor takes part in the International Clearinghouse for Birth Defects Monitoring System. Three continuously increasing trends were detected in 1973--1976. They may be connected with the more complete notifications, although the increase of limb reduction deformities are only partly explained by this factor. Transitional (quarterly) significant clusters were observed in the case of anencephaly (1974, IV), spina bifida (1974, II; and 1975, III; 1976, III), cleft lip +/- cleft palate (1974, III). The possibility of three technical biases (changes in diagnosis, notification and evaluation of the given congenital malformation) has to be excluded before accepting the fact of a real epidemic. Subsequently, a case-control epidemiological study by personal interviews and with matched controls has to be performed.

  12. 48 CFR 3415.406-3 - Part II-Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Part II-Contract clauses. 3415.406-3 Section 3415.406-3 Federal Acquisition Regulations System DEPARTMENT OF EDUCATION ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and...

  13. EXPRESS Rack Technology for Space Station

    NASA Technical Reports Server (NTRS)

    Davis, Ted B.; Adams, J. Brian; Fisher, Edward M., Jr.; Prickett, Guy B.; Smith, Timothy G.

    1999-01-01

    The EXPRESS rack provides accommodations for standard Mid-deck Locker and ISIS drawer payloads on the International Space Station. A design overview of the basic EXPRESS rack and two derivatives, the Human Research Facility and the Habitat Holding Rack, is given in Part I. In Part II, the design of the Solid State Power Control Module (SSPCM) is reviewed. The SSPCM is a programmable and remotely controllable power switching and voltage conversion unit which distributes and protects up to 3kW of 12OVDC and 28VDC power to payloads and rack subsystem components. Part III details the development and testing of a new data storage device, the BRP EXPRESS Memory Unit (BEMU). The BEMU is a conduction-cooled device which operates on 28VDC and is based on Boeing-modified 9GB commercial disk-drive technology. In Part IV results of a preliminary design effort for a rack Passive Damping System (PDS) are reported. The PDS is intended to isolate ISPR-based experiment racks from on-orbit vibration. System performance predictions based on component developmental testing indicate that such a system can provide effective isolation at frequencies of 1 Hz and above.

  14. Matematicas Para El Primer Ciclo Secundario, Volumen II (Parte 1). Traduccion Preliminar de la Edicion en Ingles Revisada. (Mathematics for Junior High School, Volume II, Part 1. Preliminary Translation of the Revised English Edition).

    ERIC Educational Resources Information Center

    Anderson, R. D.; And Others

    This is part one of a two-part SMSG mathematics text for junior high school students. Key ideas emphasized are structure of arithmetic from an algebraic viewpoint, the real number system as a progressing development, and metric and non-metric relations in geometry. Chapter topics include number line and coordinates, equations, scientific notation,…

  15. Stability Improvement of High-Pressure-Ratio Turbocharger Centrifugal Compressor by Asymmetric Flow Control-Part I: Non-Axisymmetrical Flow in Centrifugal Compressor.

    PubMed

    Yang, Mingyang; Zheng, Xinqian; Zhang, Yangjun; Bamba, Takahiro; Tamaki, Hideaki; Huenteler, Joern; Li, Zhigang

    2013-03-01

    This is Part I of a two-part paper documenting the development of a novel asymmetric flow control method to improve the stability of a high-pressure-ratio turbocharger centrifugal compressor. Part I focuses on the nonaxisymmetrical flow in a centrifugal compressor induced by the nonaxisymmetrical geometry of the volute while Part II describes the development of an asymmetric flow control method to avoid the stall on the basis of the characteristic of nonaxisymmetrical flow. To understand the asymmetries, experimental measurements and corresponding numerical simulation were carried out. The static pressure was measured by probes at different circumferential and stream-wise positions to gain insights about the asymmetries. The experimental results show that there is an evident nonaxisymmetrical flow pattern throughout the compressor due to the asymmetric geometry of the overhung volute. The static pressure field in the diffuser is distorted at approximately 90 deg in the rotational direction of the volute tongue throughout the diffuser. The magnitude of this distortion slightly varies with the rotational speed. The magnitude of the static pressure distortion in the impeller is a function of the rotational speed. There is a significant phase shift between the static pressure distributions at the leading edge of the splitter blades and the impeller outlet. The numerical steady state simulation neglects the aforementioned unsteady effects found in the experiments and cannot predict the phase shift, however, a detailed asymmetric flow field structure is obviously obtained.

  16. Experimental characterization and macro-modeling of mechanical strength of multi-sheets and multi-materials spot welds under pure and mixed modes I and II

    NASA Astrophysics Data System (ADS)

    Chtourou, Rim; Haugou, Gregory; Leconte, Nicolas; Zouari, Bassem; Chaari, Fahmi; Markiewicz, Eric

    2015-09-01

    Resistance Spot Welding (RSW) of multiple sheets with multiple materials are increasingly realized in the automotive industry. The mechanical strength of such new generation of spot welded assemblies is not that much dealt with. This is true in particular for experiments dedicated to investigate the mechanical strength of spot weld made by multi sheets of different grades, and their macro modeling in structural computations. Indeed, the most published studies are limited to two sheet assemblies. Therefore, in the first part of this work an advanced experimental set-up with a reduced mass is proposed to characterize the quasi-static and dynamic mechanical behavior and rupture of spot weld made by several sheets of different grades. The proposed device is based on Arcan test, the plates contribution in the global response is, thus, reduced. Loading modes I/II are, therefore, combined and well controlled. In the second part a simplified spot weld connector element (macroscopic modeling) is proposed to describe the nonlinear response and rupture of this new generation of spot welded assemblies. The weld connector model involves several parameters to be set. The remaining parameters are finally identified through a reverse engineering approach using mechanical responses of experimental tests presented in the first part of this work.

  17. Computational Methods for Control in Partial Differential Equations

    DTIC Science & Technology

    1998-07-13

    supported in part under this grant are C. Musante (Ph.D. thesis completed in May, 1998), M. Buksas (Ph.D. thesis to be completed in August, 1998) and M...continuing initial promising simulation findings. A summary of theoretical and numerical results to date is given in the Ph.D. thesis of Musante [4]. II... Musante and Buksas in visits to Brooks Air Force Base. The collaborations intensified during 1997 with the following visits: 1. June 15-August 30

  18. U.S. Department of Agriculture: Improving Management of Cross-Cutting Agricultural Issues

    DTIC Science & Technology

    1991-03-01

    Office HACCP Hazard Analysis and Critical Control Point MBO management-by-objectives N&suLwc National Association of State and Land-Grant U...iiAccp to low -acid canned foods. As with canned foods, a successful HACCP system will require a joint effort by industry arnd gov- ernment. Several other...bacteria to protect strawberry and potato plants from frost was delayed for 4 years partly because of environmentalists’ opposition to the test. At the

  19. Automated Work Packages Prototype: Initial Design, Development, and Evaluation. Light Water Reactor Sustainability Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oxstrand, Johanna Helene; Ahmad Al Rashdan; Le Blanc, Katya Lee

    The goal of the Automated Work Packages (AWP) project is to demonstrate how to enhance work quality, cost management, and nuclear safety through the use of advanced technology. The work described in this report is part of the digital architecture for a highly automated plant project of the technical program plan for advanced instrumentation, information, and control (II&C) systems technologies. This report addresses the DOE Milestone M2LW-15IN0603112: Describe the outcomes of field evaluations/demonstrations of the AWP prototype system and plant surveillance and communication framework requirements at host utilities. A brief background to the need for AWP research is provided, thenmore » two human factors field evaluation studies are described. These studies focus on the user experience of conducting a task (in this case a preventive maintenance and a surveillance test) while using an AWP system. The remaining part of the report describes an II&C effort to provide real time status updates to the technician by wireless transfer of equipment indications and a dynamic user interface.« less

  20. Coupled Climate-Economy-Biosphere (CoCEB) model - Part 2: Deforestation control and investment in carbon capture and storage technologies

    NASA Astrophysics Data System (ADS)

    Ogutu, K. B. Z.; D'Andrea, F.; Ghil, M.; Nyandwi, C.; Manene, M. M.; Muthama, J. N.

    2015-04-01

    This study uses the global climate-economy-biosphere (CoCEB) model developed in Part 1 to investigate economic aspects of deforestation control and carbon sequestration in forests, as well as the efficiency of carbon capture and storage (CCS) technologies as policy measures for climate change mitigation. We assume - as in Part 1 - that replacement of one technology with another occurs in terms of a logistic law, so that the same law also governs the dynamics of reduction in carbon dioxide emission using CCS technologies. In order to take into account the effect of deforestation control, a slightly more complex description of the carbon cycle than in Part 1 is needed. Consequently, we add a biomass equation into the CoCEB model and analyze the ensuing feedbacks and their effects on per capita gross domestic product (GDP) growth. Integrating biomass into the CoCEB and applying deforestation control as well as CCS technologies has the following results: (i) low investment in CCS contributes to reducing industrial carbon emissions and to increasing GDP, but further investment leads to a smaller reduction in emissions, as well as in the incremental GDP growth; and (ii) enhanced deforestation control contributes to a reduction in both deforestation emissions and in atmospheric carbon dioxide concentration, thus reducing the impacts of climate change and contributing to a slight appreciation of GDP growth. This effect is however very small compared to that of low-carbon technologies or CCS. We also find that the result in (i) is very sensitive to the formulation of CCS costs, while to the contrary, the results for deforestation control are less sensitive.

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