Turbo Pascal Implementation of a Distributed Processing Network of MS-DOS Microcomputers Connected in a Master-Slave Configuration

DTIC Science & Technology

1989-12-01

Interrupt Procedures ....... 29 13. Support for a Larger Memory Model ................ 29 C. IMPLEMENTATION ........................................ 29...describe the programmer’s model of the hardware utilized in the microcomputers and interrupt driven serial communication considerations. Chapter III...Central Processor Unit The programming model of Table 2.1 is common to the Intel 8088, 8086 and 80x86 series of microprocessors used in the IBM PC/AT

COMPARISON OF THREE ALGORITHMS FOR BASAL INSULIN IN TRANSITIONING STABLE POST-CARDIOTHORACIC SURGERY PATIENTS FROM INTRAVENOUS TO SUBCUTANEOUS INSULIN

PubMed Central

Dungan, Kathleen; Hall, Christine; Schuster, Dara; Osei, Kwame

2011-01-01

Objective The objective was to determine the efficacy of an algorithim containing aspart dosed according to carbohydrate intake and one of 3 initial doses of detemir in stable cardiac surgery patients requiring intravenous (IV) insulin. Methods Patients were extubated, off pressors and otherwise stable, requiring at least 1 unit/hr of IV insulin at least 48 hours following surgery. Subjects were randomized to once daily detemir at 50, 65, or 80% of IV basal insulin requirements and received aspart according to carbohydrate intake. The dose of detemir was adjusted daily over 72 hours. Results The number of patients with an initial morning glucose 80–130 mg/dl was 36, 63, and 56% of patients at the 50, 65, and 80% doses (p=0.12) (n=82). However, the mean overall glucose at 24 and 72 hours was similar between groups, and 86, 93, and 92% achieved a mean glucose 80–180 mg/dl at 72 hours (p=0.60). Hypoglycemia (<65 mg/dl) only occurred in the 65% (21%) and 80% (12%) groups over the first 72 hours (p=0.02 in the 50% compared to the 65 and 80% groups combined) with one event <40 mg/dl in the 80% group. There was no loss of glycemic control by the end of the once daily dosing interval. Conclusions Glycemic targets can be achieved without hypoglycemia by 72 hours in most cardiac surgery patients requiring IV insulin with a regimen containing an initial detemir dose of 50% of basal IV insulin requirements and prandial and supplemental insulin. PMID:21550950

The Generation and Radiation of Supersonic Jet Noise. Volume 3. Turbulent Mixing Noise Data

DTIC Science & Technology

1976-06-23

83,8 83.3 83.0 4000.0 87.2 86.1 85.1 84.4 84,1 83.6 5000.0 87.2 86.3 84.9 84o7 84.3 83.9 6300.0 8796 86,6 85.3 84.9 84.5 84.5 8000.0 87,2 86.4 85.0...83.6 85.6 86.7 8901 88.2 6300.0 78.9 82.3 84.3 85.8 88.3 8796 8000.0 78.5 80o9 83o0 84.8 87,6 87.2 10000.0 78.8 80.7 81.9 83.2 86,8 86.7 12500.0 77.5

Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008–2012

PubMed Central

Date, Kashmira A.; Newton, Anna E.; Medalla, Felicita; Blackstock, Anna; Richardson, LaTonia; McCullough, Andre; Mintz, Eric D.; Mahon, Barbara E.

2016-01-01

Background Enteric fever in the United States has been primarily associated with travel and with worrisome changes in global patterns of antimicrobial resistance. We present the first comprehensive report of National Typhoid and Paratyphoid Fever Surveillance System (NTPFS) data for a 5-year period (2008–2012). Methods We reviewed data on laboratory-confirmed cases reported to NTPFS, and related antimicrobial susceptibility results of Salmonella Typhi and Paratyphi A isolates sent for testing by participating public health laboratories to the Centers for Disease Control and Prevention’s National Antimicrobial Resistance Monitoring System laboratory. Results During 2008–2012, 2341 enteric fever cases were reported, 80% typhoid and 20% paratyphoid A. The proportion caused by paratyphoid A increased from 16% (2008) to 22% (2012). Foreign travel within 30 days preceding illness onset was reported by 1961 (86%) patients (86% typhoid and 92% paratyphoid A). Travel to southern Asia was common (82% for typhoid, 97% for paratyphoid A). Among 1091 (58%) typhoid and 262 (56%) paratyphoid A isolates tested for antimicrobial susceptibility, the proportion resistant to nalidixic acid (NAL-R) increased from 2008 to 2012 (Typhi, 60% to 68%; Paratyphi A, 91% to 94%). Almost all NAL-R isolates were resistant or showed decreased susceptibility to ciprofloxacin. Resistance to at least ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole (multidrug resistant [MDR]) was limited to Typhi isolates, primarily acquired in southern Asia (13%). Most MDR isolates were also NAL-R. Conclusions Enteric fever in the United States is primarily associated with travel to southern Asia, and increasing resistance is adding to treatment challenges. A bivalent typhoid and paratyphoid vaccine is needed. PMID:27090993

Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008-2012.

PubMed

Date, Kashmira A; Newton, Anna E; Medalla, Felicita; Blackstock, Anna; Richardson, LaTonia; McCullough, Andre; Mintz, Eric D; Mahon, Barbara E

2016-08-01

Enteric fever in the United States has been primarily associated with travel and with worrisome changes in global patterns of antimicrobial resistance. We present the first comprehensive report of National Typhoid and Paratyphoid Fever Surveillance System (NTPFS) data for a 5-year period (2008-2012). We reviewed data on laboratory-confirmed cases reported to NTPFS, and related antimicrobial susceptibility results of Salmonella Typhi and Paratyphi A isolates sent for testing by participating public health laboratories to the Centers for Disease Control and Prevention's National Antimicrobial Resistance Monitoring System laboratory. During 2008-2012, 2341 enteric fever cases were reported, 80% typhoid and 20% paratyphoid A. The proportion caused by paratyphoid A increased from 16% (2008) to 22% (2012). Foreign travel within 30 days preceding illness onset was reported by 1961 (86%) patients (86% typhoid and 92% paratyphoid A). Travel to southern Asia was common (82% for typhoid, 97% for paratyphoid A). Among 1091 (58%) typhoid and 262 (56%) paratyphoid A isolates tested for antimicrobial susceptibility, the proportion resistant to nalidixic acid (NAL-R) increased from 2008 to 2012 (Typhi, 60% to 68%; Paratyphi A, 91% to 94%). Almost all NAL-R isolates were resistant or showed decreased susceptibility to ciprofloxacin. Resistance to at least ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole (multidrug resistant [MDR]) was limited to Typhi isolates, primarily acquired in southern Asia (13%). Most MDR isolates were also NAL-R. Enteric fever in the United States is primarily associated with travel to southern Asia, and increasing resistance is adding to treatment challenges. A bivalent typhoid and paratyphoid vaccine is needed. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Current status of cleaning and disinfection for gastrointestinal endoscopy in China: a survey of 122 endoscopy units.

PubMed

Zhang, Xiuli; Kong, Jinyan; Tang, Ping; Wang, Shufang; Hyder, Qurratulain; Sun, Gang; Zhang, Rugang; Yang, Yunsheng

2011-04-01

Adequate compliance with the existing guidelines for cleaning and disinfection of gastrointestinal endoscopes and accessories is necessary to obtain high-level disinfection and prevent pathogen transmission. To investigate cleaning and disinfection practice in China. A questionnaire with 21 questions concerning gastrointestinal endoscopy reprocessing was sent by e-mail to 189 endoscopy units in China. One hundred and twenty-two (80.39%) of the 189 units responded. Compared with the low-workload units (<5000 procedures/year), the high-workload units (≥5000 procedures/year) had a significantly higher number of gastrointestinal endoscopes (25.8 ± 3.6 vs. 4.7 ± 1.8, p < 0.01) and the higher possessing rate of automated endoscope reprocessors (43.9% vs. 3.1%, p<0.01). Glutaraldehyde was the most commonly employed disinfectant (88.5%) in all the units. In 23/122 (18.8%) units, the exposure time to glutaraldehyde was <45 min in the case of infectious disease patients. Eighty-six of 122 (70.5%) units reused disposable materials, of which 21/86 (24.4%) reused disposable forceps and disposable polypectomy hooks, and 2/86 (1.6%) reused disposable injection needles intermittently. Although gastrointestinal endoscopy has developed rapidly in China in the past decade, there is still room for improvement in the practice of endoscopy reprocessing, especially in middle-sized and small cities. Copyright © 2011 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Department of Defense Atlas/Data Abstract for the United States and Selected Areas. Fiscal Year 1992

DTIC Science & Technology

1993-01-01

PUBLICATION IS DIOR/L-03-92, TABLE OF CONTENTS Page INTRODUCTION ........................................................... 2 MAPS AND STATISTICAL...Mexico (NH) 32 80 New York (NY) 33 82 North Carolina (NC) 34 84 North Dakota (ND) 35 86 Ohio (OH) 36 88 TABLE OF CONTENTS (Continued) State/Area Map...ZIMMERMIANN BASIL CORP JV 34,679 Operation/Ammunition Facilities 34,679 3. MORRISON KNUDSEN CORP 30,923 Facilities Operations Support Services 30,923 4

Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders.

PubMed

Panegyres, P K; Zafiris-Toufexis, K; Kakulas, B A

2000-02-15

Differential expression of the amyloid precursor protein gene (APP) may be important in the development of amyloidosis in Alzheimer's disease (AD) and experimentally in the brain's response to injury. Controversial data suggests that APP isoforms containing the Kunitz protease inhibitor isoform (APP KPI+) are over expressed in the brains of patients with AD when compared to the non-Kunitz protease inhibitor containing isoforms (APP KPI-). We have investigated this hypothesis using a quantitative analysis of gene expression on brain tissue collected at post-mortem. In situ hybridization has been used with synthetic oligonucleotide probes labelled with 35S to detect the two principal splice variants of APP: APP 695 (KPI-) and APP 751 (KPI+). A prospective brain bank of frozen brain specimens has been established and includes pathologically proven AD (n=15) and other neurodegenerative disorders as controls (n=18). The controls consist of frontal lobe atrophy (n=4), Huntington's disease (n=5), Parkinson's disease (n=4), motor neuron disease (n=2), multi-infarct dementia (n=1), multisystem atrophy (n=1), and subacute sclerosing panencephalitis (n=1). We have observed no significant differences in the expression of APP 695 KPI- mRNA in frontal lobe: 17.49+/-3.26 optical density (OD) units of mRNA expression in AD vs. 16.13+/-1.76 OD units mRNA in controls (P=0.80, linear regression); or temporal lobe: 14.73+/-2.96 in AD vs. 16.49+/-2.15 in controls (P=0.55). No significant differences have been found in APP 751 KPI+ in frontal lobe: 12.86+/-2.98 in AD vs. 13.70+/-2.88 in controls (P=0.97); and temporal lobe: 13.31+/-4.93 in AD vs. 11.07+/-1.99 in controls (P=0. 65). Analysis of the ratios of APP 751 KPI+ OD units of mRNA to APP 695 KPI- mRNA revealed a trend to an increased ratio which did not reach statistical significance: frontal lobe APP 751 KPI+/APP 695 KPI- 1.92+/-1.04 in AD vs. 0.86+/-0.17 in controls (P=0.54); temporal lobe 2.54+/-1.59 in AD vs. 0.96+/-0.11 controls (P=0.34). Our data has not revealed differential expression of APP mRNA isoforms in AD and supports the hypothesis that post-translational events in APP metabolism are important in amyloidogenesis and the pathogenesis of AD.

Internal quality control of blood products: An experience from a tertiary care hospital blood bank from Southern Pakistan.

PubMed

Sultan, Sadia; Zaheer, Hasan Abbas; Waheed, Usman; Baig, Mohammad Amjad; Rehan, Asma; Irfan, Syed Mohammed

2018-01-01

Internal quality control (IQC) is the backbone of quality assurance program. In blood banking, the quality control of blood products ensures the timely availability of a blood component of high quality with maximum efficacy and minimal risk to potential recipients. The main objective of this study is to analyze the IQC of blood products as an indicator of our blood bank performance. An observational cross-sectional study was conducted at the blood bank of Liaquat National Hospital and Medical College, from January 2014 to December 2015. A total of 100 units of each blood components were arbitrarily chosen during the study. Packed red cell units were evaluated for hematocrit (HCT); random platelet concentrates were evaluated for pH, yield, and culture; fresh frozen plasma (FFP) and cryoprecipitate (CP) were evaluated for unit volume, factor VIII, and fibrinogen concentrations. A total of 400 units were tested for IQC. The mean HCT of packed red cells was 69.5 ± 7.24, and in 98% units, it met the standard (<80% of HCT). The mean platelet yield was 8.8 ± 3.40 × 10 9 /L and pH was ≥6.2 in 98% bags; cultures were negative in 97% of units tested. Mean factor VIII and fibrinogen levels were found to be 84.24 ± 15.01 and 247.17 ± 49.69 for FFP, respectively. For CP, mean factor VIII and fibrinogen level were found to be 178.75 ± 86.30 and 420.7 ± 75.32, respectively. The IQC of blood products at our blood bank is in overall compliance and met recommended international standards. Implementation of standard operating procedures, accomplishment of standard guidelines, proper documentation with regular audit, and staff competencies can improve the quality performance of the transfusion services.

Nanoethosomes mediated transdermal delivery of vinpocetine for management of Alzheimer's disease.

PubMed

Moghaddam, Atefeh Afshar; Aqil, Mohd; Ahmad, Farhan J; Ali, Mushir M; Sultana, Yasmin; Ali, Asgar

2015-12-01

To develop and statistically optimize nanoethosomal formulation for transdermal delivery of vinpocetine as an anti-Alzheimer's drug. Box-Behnken experimental design was applied for optimization of nanoethosomes. The independent variables were phospholipid (X 1 ), Tween 80 (X 2 ) and Ethanol (X 3 ) while entrapment efficiency (Y 1 ), particle sizes (Y 2 ), elasticity (Y 3 ) and flux (Y 4 ) were the dependent variables. Optimized nanoethosomal vinpocetine formulation with mean particle size 50.57 ± 26.11 nm showed 97.51 ± 0.86% entrapment efficiency, achieved mean transdermal flux 925.60 ± 39.80 µg/cm 2 /h and elasticity of 86.61 ± 2.88. Ex-vivo study of nanoethosomal formulation showed a significant increase flux and entrapment efficiency compared with control vinpocetine solution. Our results suggest that nanoethosome is an efficient carrier for transdermal delivery of vinpocetine as compared to its oral form.

CD80 and CD86 IgC domains are important for quaternary structure, receptor binding and co-signaling function.

PubMed

Girard, Tanya; Gaucher, Denis; El-Far, Mohamed; Breton, Gaëlle; Sékaly, Rafick-Pierre

2014-09-01

CD86 and CD80, the ligands for the co-stimulatory molecules CD28 and CTLA-4, are members of the Ig superfamily. Their structure includes Ig variable-like (IgV) domains, Ig constant-like (IgC) domains and intracellular domains. Although crystallographic studies have clearly identified the IgV domain to be responsible for receptor interactions, earlier studies suggested that both Ig domains are required for full co-signaling function. Herein, we have used deletion and chimeric human CD80 and CD86 molecules in co-stimulation assays to study the impact of the multimeric state of IgV and IgC domains on receptor binding properties and on co-stimulatory function in a peptide-specific T cell activation model. We report for the first time the presence of CD80 dimers and CD86 monomers in living cells. Moreover, we show that the IgC domain of both molecules inhibits multimer formation and greatly affects binding to the co-receptors CD28 and CTLA-4. Finally, both IgC and intracellular domains are required for full co-signaling function. These findings reveal the distinct but complementary roles of CD80 and CD86 IgV and IgC domains in T cell activation. Copyright © 2014 Elsevier B.V. All rights reserved.

50 CFR 80.21 - What if a State diverts license revenue from the control of its fish and wildlife agency?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What if a State diverts license revenue from the control of its fish and wildlife agency? 80.21 Section 80.21 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE...

50 CFR 80.21 - What if a State diverts license revenue from the control of its fish and wildlife agency?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false What if a State diverts license revenue from the control of its fish and wildlife agency? 80.21 Section 80.21 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE...

50 CFR 80.21 - What if a State diverts license revenue from the control of its fish and wildlife agency?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false What if a State diverts license revenue from the control of its fish and wildlife agency? 80.21 Section 80.21 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE...

50 CFR 80.21 - What if a State diverts license revenue from the control of its fish and wildlife agency?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What if a State diverts license revenue from the control of its fish and wildlife agency? 80.21 Section 80.21 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE...

40 CFR 86.004-25 - Maintenance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... injectors. (B) Turbocharger. (C) Electronic engine control unit and its associated sensors and actuators. (D... paragraphs (b)(4)(iv) (A)-(G) of this section. (A) Fuel injectors. (B) Turbocharger. (C) Electronic engine...

50 CFR 80.132 - Does an agency have to control the land or water where it completes capital improvements?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false Does an agency have to control the land or water where it completes capital improvements? 80.132 Section 80.132 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE AND SPORT FISH RESTORATION PROGRAM...

Petrogenesis of mesozoic, peraluminous granites in the Lamoille canyon area, Ruby mountains, Nevada, USA

USGS Publications Warehouse

Lee, S.-Y.; Barnes, C.G.; Snoke, A.W.; Howard, K.A.; Frost, C.D.

2003-01-01

Two groups of closely associated, peraluminous, two-mica granitic gneiss were identified in the area. The older, sparsely distributed unit is equigranular (EG) with initial ??Nd ??? -8??8 and initial 87Sr/86Sr ???0??7098. Its age is uncertain. The younger unit is Late Cretaceous (???80 Ma), pegmatitic, and sillimanite-bearing (KPG), with ??Nd from -15??8 to -17??3 and initial 87Sr/86Sr from 0??7157 to 0??7198. The concentrations of Fe, Mg, Na, Ca, Sr, V, Zr, Zn and Hf are higher, and K, Rb and Th are lower in the EG. Major- and trace-element models indicate that the KPG was derived by muscovite dehydration melting (<35 km depth) of Neoproterozoic metapelitic rocks that are widespread in the eastern Great Basin. The models are broadly consistent with anatexis of crust tectonically thickened during the Sevier orogeny; no mantle mass or heat contribution was necessary. As such, this unit represents one crustal end-member of regional Late Cretaceous peraluminous granites. The EG was produced by biotite dehydration melting at greater depths, with garnet stable in the residue. The source of the EG was probably Paleoproterozoic metagraywacke. Because EG magmatism probably pre-dated Late Cretaceous crustal thickening, it required heat input from the mantle or from mantle-derived magma.

Risk factors for Toxoplasma gondii infection in the United States.

PubMed

Jones, Jeffrey L; Dargelas, Valerie; Roberts, Jacquelin; Press, Cindy; Remington, Jack S; Montoya, Jose G

2009-09-15

Toxoplasmosis can cause severe ocular and neurological disease. We sought to determine risk factors for Toxoplasma gondii infection in the United States. We conducted a case-control study of adults recently infected with T. gondii. Case patients were selected from the Palo Alto Medical Foundation Toxoplasma Serology Laboratory from August 2002 through May 2007; control patients were randomly selected from among T. gondii-seronegative persons. Data were obtained from serological testing and patient questionnaires. We evaluated 148 case patients with recent T. gondii infection and 413 control patients. In multivariate analysis, an elevated risk of recent T. gondii infection was associated with the following factors: eating raw ground beef (adjusted odds ratio [aOR], 6.67; 95% confidence limits [CLs], 2.09, 21.24; attributable risk [AR], 7%); eating rare lamb (aOR, 8.39; 95% CLs, 3.68, 19.16; AR, 20%); eating locally produced cured, dried, or smoked meat (aOR, 1.97; 95% CLs, 1.18, 3.28; AR, 22%); working with meat (aOR, 3.15; 95% CLs, 1.09, 9.10; AR, 5%); drinking unpasteurized goat's milk (aOR, 5.09; 95% CLs, 1.45, 17.80; AR, 4%); and having 3 or more kittens (aOR, 27.89; 95% CLs, 5.72, 135.86; AR, 10%). Eating raw oysters, clams, or mussels (aOR, 2.22; 95% CLs, 1.07, 4.61; AR, 16%) was significant in a separate model among persons asked this question. Subgroup results are also provided for women and for pregnant women. In the United States, exposure to certain raw or undercooked foods and exposure to kittens are risk factors for T. gondii infection. Knowledge of these risk factors will help to target prevention efforts.

Accreted fragments of the Late Cretaceous Caribbean Colombian Plateau in Ecuador

NASA Astrophysics Data System (ADS)

Mamberti, Marc; Lapierre, Henriette; Bosch, Delphine; Jaillard, Etienne; Ethien, Raynald; Hernandez, Jean; Polvé, Mireille

2003-02-01

The eastern part of the Western Cordillera of Ecuador includes fragments of an Early Cretaceous (≈123 Ma) oceanic plateau accreted around 85-80 Ma (San Juan-unit). West of this unit and in fault contact with it, another oceanic plateau sequence (Guaranda unit) is marked by the occurrence of picrites, ankaramites, basalts, dolerites and shallow level gabbros. A comparable unit is also exposed in northwestern coastal Ecuador (Pedernales unit). Picrites have LREE-depleted patterns, high ɛNd i and very low Pb isotopic ratios, suggesting that they were derived from an extremely depleted source. In contrast, the ankaramites and Mg-rich basalts are LREE-enriched and have radiogenic Pb isotopic compositions similar to the Galápagos HIMU component; their ɛNd i are slightly lower than those of the picrites. Basalts, dolerites and gabbros differ from the picrites and ankaramites by flat rare earth element (REE) patterns and lower ɛNd; their Pb isotopic compositions are intermediate between those of the picrites and ankaramites. The ankaramites, Mg-rich basalts, and picrites differ from the lavas from the San Juan-Multitud Unit by higher Pb ratios and lower ɛNd i. The Ecuadorian and Gorgona 88-86 Ma picrites are geochemically similar. The Ecuadorian ankaramites and Mg-rich basalts share with the 92-86 Ma Mg-rich basalts of the Caribbean-Colombian Oceanic Plateau (CCOP) similar trace element and Nd and Pb isotopic chemistry. This suggests that the Pedernales and Guaranda units belong to the Late Cretaceous CCOP. The geochemical diversity of the Guaranda and Pedernales rocks illustrates the heterogeneity of the CCOP plume source and suggests a multi-stage model for the emplacement of these rocks. Stratigraphic and geological relations strongly suggest that the Guaranda unit was accreted in the late Maastrichtian (≈68-65 Ma).

Preparation and evaluation of sustained drug release from pluronic polyol rectal suppositories.

PubMed

Anderson, D; Amomo, M M

2001-01-01

Suppository dosage forms offer several advantages in drug delivery and can be compounded in a pharmacy setting for the needs of the individual patient. In this study, we have examined the use of Pluronic polyols in the development of sustained-release rectal suppository formulations. Solid and liquid Pluronic poyols (Pluronic L61, F68, L101, and F108) were combined in a weight ratio ranging from 80:20 (solid to liquid) to 70:30 to prepare the bases. The release behavior of a model drug, riboflavin, from the suppositories wee evaluated by means of the United Stated Pharmacopeia Basket Dissolution Method. When compared with the control Polybase suppository, which released 50% of the drug (t50) in about 7.23 minutes, Pluronic F68/L61 suppositories at an 80:20 weight ratio exhibited a t50 of 86.5 minutes (1.44 hours). Riboflavin release from suppositories made with Pluronic F108/L101 was even further delayed. The t50 of riboflavin from Pluronic F108/L101 suppositories at an 80:20 weight ratio, for instance, was 274.4 minutes (4.6 hours). The results of this study show that by choosing specific combinations of Pluronic polyols and weight ratios, compounding pharmacists can prepare sustained-release suppository formulations that can deliver drugs within minutes to hours. This flexibility of compounding sustained-release suppositories is beneficial, especially for the management of chronic pain in cancer patients.

Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses.

PubMed

Bugeon, L; Hargreaves, R E; Crompton, T; Outram, S; Rahemtulla, A; Porter, A C; Dallman, M J

2001-01-01

Co-stimulation provided by the B7 family of proteins underpins the development of protective immunity. There are three identified members of this family: CD80, its splice variant IgV-CD80 and CD86. It has hitherto been difficult to analyze the expression and function of IgV-CD80 since there are no appropriate reagents capable of distinguishing it from CD80. We have generated mice, by gene targeting, the lack CD80 whilst maintaining expression of IgV-CD80. Mutant animals did not delete T cells bearing mammary tumor virus-reactive TCR as efficiently as wild-type animals. We also demonstrate the importance of IgV-CD80 in the responses of recently activated cells and reveal a role for CD80 in sustaining T cell responses. CD86, whilst critical to primary T cell activation, made only a minor contribution to re-activation of normal cells.

Survey of illegal immigrants seen in an emergency department.

PubMed Central

Chan, T C; Krishel, S J; Bramwell, K J; Clark, R F

1996-01-01

There is growing controversy regarding illegal immigrants and their use of social services, including health care, in this country. We surveyed undocumented persons presenting at our emergency department to investigate the reasons why they sought care in the United States. Overall, 227 visits (8.6%) were made in the emergency department by illegal immigrants, mostly Hispanics. Of 104 patients surveyed, all sought care in this country because they were here at the time, and 86 (83%) intended to remain permanently. Of the 104 persons, 83 (80%) cited lack of funding as a reason for seeking emergency department care. Undocumented Hispanics had a higher uninsured rate (64%) than both Hispanics (32%) and non-Hispanics (30%). Of the 104 patients, 38 (36%) had difficulty obtaining care elsewhere because of their status, 53 (51%) knew of no other sources of care, and 46 (44%) said that even if available, only the emergency department was acceptable. Many undocumented persons seek care in the United States because they reside here permanently, often using this emergency department as their source of care. These findings may be important in light of recent efforts to restrict services for this group. PMID:8775931

Utilization of case presentations in medical microbiology to enhance relevance of basic science for medical students.

PubMed

Chamberlain, Neal R; Stuart, Melissa K; Singh, Vineet K; Sargentini, Neil J

2012-01-01

Small-group case presentation exercises (CPs) were created to increase course relevance for medical students taking Medical Microbiology (MM) and Infectious Diseases (ID) METHODS: Each student received a unique paper case and had 10 minutes to review patient history, physical exam data, and laboratory data. Students then had three minutes to orally present their case and defend why they ruled in or out each of the answer choices provided, followed by an additional three minutes to answer questions. Exam scores differed significantly between students who received the traditional lecture-laboratory curriculum (Group I) and students who participated in the CPs (Group II). In MM, median unit exam and final exam scores for Group I students were 84.4% and 77.8%, compared to 86.0% and 82.2% for Group II students (P<0.018; P<0.001; Mann-Whitney Rank Sum Test). Median unit and final ID exam scores for Group I students were 84.0% and 80.0%, compared to 88.0% and 86.7% for Group II students (P<0.001; P<0.001). Students felt that the CPs improved their critical thinking and presentation skills and helped to prepare them as future physicians.

Sampling and Analysis for Non-Occupational Pesticide Exposure Assessments

EPA Science Inventory

Pesticides are used extensively in the United States to control a variety of pests. Commercial agriculture and non-agricultural industries account for about 80% of the total pesticide use in the United States, while the remaining 20% is used for pest control associated with home,...

Probiotic metabolites from Bacillus coagulans GanedenBC30TM support maturation of antigen-presenting cells in vitro

PubMed Central

Benson, Kathleen F; Redman, Kimberlee A; Carter, Steve G; Keller, David; Farmer, Sean; Endres, John R; Jensen, Gitte S

2012-01-01

AIM: To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells. METHODS: Ganeden Bacillus coagulans 30 (GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite (MET) fraction. A second fraction was made to generate a crude cell-wall-enriched fraction, by centrifugation and lysis, followed by washing. A preparation of MET was subjected to size exclusion centrifugation, generating three fractions: < 3 kDa, 3-30 kDa, and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell (PBMC) as a source of antigen-presenting mononuclear phagocytes. The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14, CD16, CD80 and CD86 and analyzed by flow cytometry. RESULTS: Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes. The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells, and this property was associated with the high molecular weight metabolite fraction. Changes were also seen for the dendritic cell maturation markers CD80 and CD86. On CD14dim cells, an increase in both CD80 and CD86 expression was seen, in contrast to a selective increase in CD86 expression on CD14bright cells. The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation. The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells. CONCLUSION: The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells, important for immunological decision-making. PMID:22563167

Use of ventilator associated pneumonia bundle and statistical process control chart to decrease VAP rate in Syria.

PubMed

Alsadat, Reem; Al-Bardan, Hussam; Mazloum, Mona N; Shamah, Asem A; Eltayeb, Mohamed F E; Marie, Ali; Dakkak, Abdulrahman; Naes, Ola; Esber, Faten; Betelmal, Ibrahim; Kherallah, Mazen

2012-10-01

Implementation of ventilator associated pneumonia (VAP) bundle as a performance improvement project in the critical care units for all mechanically ventilated patients aiming to decrease the VAP rates. VAP bundle was implemented in 4 teaching hospitals after educational sessions and compliance rates along with VAP rates were monitored using statistical process control charts. VAP bundle compliance rates were steadily increasing from 33 to 80% in hospital 1, from 33 to 86% in hospital 2 and from 83 to 100% in hospital 3 during the study period. The VAP bundle was not applied in hospital 4 therefore no data was available. A target level of 95% was reached only in hospital 3. This correlated with a decrease in VAP rates from 30 to 6.4 per 1000 ventilator days in hospital 1, from 12 to 4.9 per 1000 ventilator days in hospital 3, whereas VAP rate failed to decrease in hospital 2 (despite better compliance) and it remained high around 33 per 1000 ventilator days in hospital 4 where VAP bundle was not implemented. VAP bundle has performed differently in different hospitals in our study. Prevention of VAP requires a multidimensional strategy that includes strict infection control interventions, VAP bundle implementation, process and outcome surveillance and education.

Design of a Microprogram Control Unit with Concurrent Error Detection.

DTIC Science & Technology

1984-08-01

I fxoot Office of Naval Research N/A N00039-80-C-0556 ta. ADDRESS (City. St.. and ZIP Cod 10. SOURCE OF FUNOING N0. -PROGRAM PROJECT TASK WORK UNIT...However, the CED concept is mainly applied to various codes data transmission, and simple functional units, such as arithmetic units. Little work has...been done in the control unit area. Previous work is primarily in the use of clanical self-checking circuits, using bit slicin& parity, and m-out-of-n

CDC grand rounds: current opportunities in tobacco control.

PubMed

2010-04-30

Tobacco use is the world's leading single preventable cause of death. Worldwide tobacco-related deaths now exceed 5 million a year. Left unchecked, the number is expected to exceed 8 million a year by 2030, and 80% of those tobacco-related deaths will occur in low- and middle-income countries. In the United States, tobacco use is the single leading preventable cause of disease, disability, and death. Each year, 443,000 U.S. residents die from cigarette smoking and exposure to secondhand smoke, and another 8.6 million have a serious illness caused by smoking. In 2008, 20.6% (approximately 46 million) of U.S. adults were current smokers. Smoking costs the United States $96 billion in medical costs and $97 billion in lost productivity annually. A particular concern is that progress in reducing smoking rates among young persons and adults has stalled. After a substantial decline from 1997 (36.4%) to 2003 (21.9%), the decline in smoking rates among high school students slowed and remained relatively unchanged from 2003 (21.9%) to 2007 (20.0%). Adult smoking prevalence declined steadily from 1965 (42.4%) through the 1980s; however, the decline in smoking rates among adults began to slow in the 1990s and remained relatively unchanged from 2004 (20.9%) to 2008 (20.6%). By achieving a modest decline in smoking prevalence worldwide (from 25% to 20%) through further use of tobacco control measures, 100 million deaths can be prevented by 2020.

The Kidney Donor Profile Index (KDPI) of marginal donors allocated by standardized pretransplant donor biopsy assessment: distribution and association with graft outcomes.

PubMed

Gandolfini, I; Buzio, C; Zanelli, P; Palmisano, A; Cremaschi, E; Vaglio, A; Piotti, G; Melfa, L; La Manna, G; Feliciangeli, G; Cappuccilli, M; Scolari, M P; Capelli, I; Panicali, L; Baraldi, O; Stefoni, S; Buscaroli, A; Ridolfi, L; D'Errico, A; Cappelli, G; Bonucchi, D; Rubbiani, E; Albertazzi, A; Mehrotra, A; Cravedi, P; Maggiore, U

2014-11-01

Pretransplant donor biopsy (PTDB)-based marginal donor allocation systems to single or dual renal transplantation could increase the use of organs with Kidney Donor Profile Index (KDPI) in the highest range (e.g. >80 or >90), whose discard rate approximates 50% in the United States. To test this hypothesis, we retrospectively calculated the KDPI and analyzed the outcomes of 442 marginal kidney transplants (340 single transplants: 278 with a PTDB Remuzzi score<4 [median KDPI: 87; interquartile range (IQR): 78-94] and 62 with a score=4 [median KDPI: 87; IQR: 76-93]; 102 dual transplants [median KDPI: 93; IQR: 86-96]) and 248 single standard transplant controls (median KDPI: 36; IQR: 18-51). PTDB-based allocation of marginal grafts led to a limited discard rate of 15% for kidneys with KDPI of 80-90 and of 37% for kidneys with a KDPI of 91-100. Although 1-year estimated GFRs were significantly lower in recipients of marginal kidneys (-9.3, -17.9 and -18.8 mL/min, for dual transplants, single kidneys with PTDB score<4 and =4, respectively; p<0.001), graft survival (median follow-up 3.3 years) was similar between marginal and standard kidney transplants (hazard ratio: 1.20 [95% confidence interval: 0.80-1.79; p=0.38]). In conclusion, PTDB-based allocation allows the safe transplantation of kidneys with KDPI in the highest range that may otherwise be discarded. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

High-resolution dating of deep-sea clays using Sr isotopes in fossil fish teeth

NASA Astrophysics Data System (ADS)

Ingram, B. Lynn

1995-09-01

Strontium isotopic compostitions of ichthyoliths (microscopic fish remains) in deep-sea clays recovered from the North Pacific Ocean (ODP holes 885A, 886B, and 886C) are used to provide stratigraphic age control within these otherwise undatable sediments. Age control within the deep-sea clays is crucial for determining changes in sedimentation rates, and for calculating fluxes of chemical and mineral components to the sediments. The Sr isotopic ages are in excellent agreement with independent age datums from above (diatom ooze), below (basalt basement) and within (Cretaceous-Tertiary boundary) the clay deposit. The 87Sr/ 86Sr ratios of fish teeth from the top of the pelagic clay unit (0.708989), indicate an Late Miocene age (5.8 Ma), as do radiolarian and diatom biostratigraphic ages in the overlying diatom ooze. The 87Sr/ 86Sr ratio (0.707887) is consistent with a Cretaceous-Tertiary boundary age, as identified by anomalously high iridium, shocked quartz, and sperules in Hole 886C. The 87Sr/ 86Sr ratios of pretreated fish teeth from the base of the clay unit are similar to Late Cretaceous seawater (0.707779-0.707519), consistent with radiometric ages from the underlying basalt of 81 Ma. Calculation of sedimentation rates based on Sr isotopic ages from Hole 886C indicate an average sedimentation rate of 17.7 m/Myr in Unit II (diatom ooze), 0.55 m/Myr in Unit IIIa (pelagic clay), and 0.68 m/Myr in Unit IIIb (distal hydrothermal precipitates). The Sr isotopic ages indicate a period of greatly reduced sedimentation (or possible hiatus) between about 35 and 65 Ma (Eocene-Paleocene), with a linear sedimentation rate of only 0.04 m/Myr The calculated sedimentation rates are generally inversely proportional to cobalt accumulation rates and ichthyolith abundances. However, discrepancies between Sr isotope ages and cobalt accumulation ages of 10-15 Myr are evident, particularly in the middle of the clay unit IIIa (Oligocene-Paleocene).

Expression of major histocompatibility complex class II and costimulatory molecules in oral carcinomas in vitro.

PubMed

Villarroel-Dorrego, Mariana; Speight, Paul M; Barrett, A William

2005-01-01

Recognition in the 1980 s that keratinocytes can express class II molecules of the Major Histocompatibility Complex (MHC) first raised the possibility that these cells might have an immunological function, and may even act as antigen presenting cells (APC). For effective T lymphocyte activation, APC require, in addition to MHC II, appropriate costimulatory signals. The aim of this study was to determine the expression of MHC class II and the co-stimulatory molecules CD40, CD80 and CD86 in keratinocytes derived from healthy oral mucosa and oral carcinomas. Using flow cytometry, it was confirmed that oral keratinocytes, switch on, expression of MHC class II molecules after stimulation with IFNgamma in vitro. All keratinocyte lines expressed CD40 constitutively; by contrast, CD80 and CD86 were universally absent. Loss of CD80 and CD86 may be one means whereby tumours escape immunological surveillance.

Command, Control, Communications, Computers and Intelligence Electronic Warfare (C4IEW) Project Book, Fiscal Year 1994. (Non-FOUO Version)

DTIC Science & Technology

1994-04-01

TSW-7A, AIR TRAFFIC CONTROL CENTRAL (ATCC) 32- 8 AN/TTC-41(V), CENTRAL OFFICE, TELEPHONE, AUTOMATIC 32- 9 MISSILE COUNTERMEASURE DEVICE (MCD) .- 0 MK...a Handheld Terminal Unit (HTU), Portable Computer Unit (PCU), Transportable Computer Unit (TCU), and compatible NOI peripheral devices . All but the...CLASSIFICATION: ASARC-III, Jun 80, Standard. I I I AN/TIC-39 IS A MOBILE , AUTOMATIC , MODULAR ELECTRONIC CIRCUIT SWITCH UNDER PROCESSOR CONTROL WITH INTEGRAL

Urinary CD80 as a Replacement for Renal Biopsy for Diagnosis of Pediatric Minimal Change Disease.

PubMed

Ahmed, Heba Mostafa; Ezzat, Dina Ahmed; Doudar, Noha A; Adel, Mai

2018-03-01

Early diagnosis of minimal change disease (MCD) is challenging in nephrotic children. CD80 is a protein expressed on the surface of podocytes associated with nephrotic syndrome and it is implicated in the induction of proteinuria. This study aimed to investigate the use of urinary CD80 for the diagnosis of MCD. Urinary CD80 levels were evaluated in 36 children with nephrotic syndrome and normal glomerular filtration rate. They were divided into three groups of MCD (n = 21), focal segmental glomerulosclerosis (n = 9), and other glomerulopathies (n = 6). The MCD group was subdivided into 2 of those with remission (n = 11) and those in the active stage (n = 10). Forty healthy children were included as controls. The urinary CD80 level was significantly higher in the MCD group (3.5 ± 2.1 ng/mg creatinine) than in the focal segmental glomerulosclerosis group (1.2 ± 0.5 ng/mg creatinine, P < .001), the other glomerulopathies group (1.4 ± 0.7 ng/mg creatinine, P < .001), and the control group (0.7 ± 0.2 ng/mg creatinine, P < .001), while it showed no significant difference among the non-MCD groups. There was no significant difference between MCD in remission and MCD in relapse, either. A urinary CD80 cutoff value of 1.5 ng/gm creatinine showed a sensitivity of 100% and a specificity of 86% for diagnosis of MCD. Urinary CD80 levels were significantly higher in the children with MCD than in the controls and patients with other causes of nephrotic syndrome.

[Level of completion of the prehospital care and transfer record as a quality indicator in an emergency medical service].

PubMed

Ballestros Peña, Sendoa; Lorrio Palomino, Sergio; Ariz Zubiaur, Mónica

2012-11-01

BASICS: A Prehospital Care and Transfer Recording (PCTR) is an out-of-hospital medical recording. This paper was made to assess and compare the level of fulfillment of the basic parameters of the PCTR developed by the Life Support Units with nurses (Life Support Units with Nurse, LSUwN and without nurses (Basic Life Support Units, BLSU) from SAMUR Bilbao in 2010. A descriptive, retrospective and comparative study was performed by analysing a randomized sample of 660 PCTR (precision 3%), aiming to check the fulfillment of the basic data. 98.33% of total recordings were readable. In overall, fulfillment rate was 90.31% (CI 89.24- 97.3 71%) of all basic parameters for LSUwN PCTR and 84.81% (CI 83.56 to 86%) for BLSU. 34.1% of PCTR were completely and correctly fulfilled. The LSUwN scored significantly better (p < 0.000). There were recording failures in "date and time", "address" and "physical examination". There were differences between the recording of clinical and administrative information (88.64% vs 86.72%, p = 0.02). In order to consider a parameter has optimal, it has to reach 100% of fulfillment. If it doesn't, and its score reaches no more than 80%, it should be reviewed. In this case, the results would be considered acceptable, but the administrative items of BLSU records, and allergies in both units should be strengthened. LSUwN has obtained better scores. The need of recording clinical information must be instilled as evidence of quality care.

Prevention of burn injuries to children involving nightwear.

PubMed

Laing, R M; Bryant, V

1991-08-28

The effectiveness of legislative intervention in the New Zealand market for children's nightclothes as an injury prevention strategy has been reassessed by examining those hospital admissions for the period 1980-8 (with emphasis on the 1985-8 period) in which clothing and/or nightclothes were involved. The profiles of the production of children's nightclothes (1977-86) and domestic heating (1984-8) were also examined. Ninety-five cases of burn injury discharges were identified (1985-8), and of those cases involving clothing 42% involved nightwear (49% 1981-4). Some of the 27% unspecified cases may have also involved nightwear (23%, 1981-4). A very strong linear downward trend for nightwear incidents was noted (chi 2 slope = 31.06, p less than 0.001). Forty-eight percent of cases involved children aged 1-6 years, and 68% involved pajamas. Stoves were the main specified ignition agent for nightclothes (36%). Open fires as a form of household heating decreased from 49% to 34% of households (1984-8). Estimated production of nightdresses in New Zealand also decreased (460,000 to 80,000 units, 1973-86). The pronounced decrease in injuries attributable to ignition of children's nightclothes is likely to be the result of mandatory controls on children's nightclothes, increased use of pyjamas, and a steady decrease in use of open fires and portable electric heaters. The typical injury event portrayed to the public of a girl in front of a heater or open fire needs to be corrected.

A Newly Identified Glutaminase-Free ʟ-Asparaginase (ʟ-ASPG86) from the Marine Bacterium Mesoflavibacter zeaxanthinifaciens.

PubMed

Lee, Su-Jin; Lee, Youngdeuk; Park, Gun-Hoo; Umasuthan, Navaneethaiyer; Heo, Soo-Jin; De Zoysa, Mahanama; Jung, Won-Kyo; Lee, Dae-Won; Kim, Hanjun; Kang, Do-Hyung; Oh, Chulhong

2016-06-28

ʟ-Asparaginase (E.C. 3.5.1.1) is an enzyme involved in asparagine hydrolysis and has the potential to effect leukemic cells and various other cancer cells. We identified the Lasparaginase gene (ʟ-ASPG86) in the genus Mesoflavibacter, which consists of a 1,035 bp open reading frame encoding 344 amino acids. Following phylogenetic analysis, the deduced amino acid sequence of ʟ-ASPG86 (ʟ-ASPG86) was grouped as a type I asparaginase with respective homologs in Escherichia coli and Yersinia pseudotuberculosis. The ʟ-ASPG86 gene was cloned into the pET-16b vector to express the respective protein in E. coli BL21 (DE3) cells. Recombinant ʟ-asparaginase (r-ʟ-ASPG86) showed optimum conditions at 37-40oC, pH 9. Moreover, r-ʟ-ASPG86 did not exhibit glutaminase activity. In the metal ions test, its enzymatic activity was highly improved upon addition of 5 mM manganese (3.97-fold) and magnesium (3.35-fold) compared with the untreated control. The specific activity of r-LASPG86 was 687.1 units/mg under optimum conditions (37°C, pH 9, and 5 mM MnSO4).

Colorectal cancer screening: Estimated future colonoscopy need and current volume and capacity.

PubMed

Joseph, Djenaba A; Meester, Reinier G S; Zauber, Ann G; Manninen, Diane L; Winges, Linda; Dong, Fred B; Peaker, Brandy; van Ballegooijen, Marjolein

2016-08-15

In 2014, a national campaign was launched to increase colorectal cancer (CRC) screening rates in the United States to 80% by 2018; it is unknown whether there is sufficient colonoscopy capacity to reach this goal. This study estimated the number of colonoscopies needed to screen 80% of the eligible population with fecal immunochemical testing (FIT) or colonoscopy and determined whether there was sufficient colonoscopy capacity to meet the need. The Microsimulation Screening Analysis-Colon model was used to simulate CRC screening test use in the United States (2014-2040); the implementation of a national screening program in 2014 with FIT or colonoscopy with 80% participation was assumed. The 2012 Survey of Endoscopic Capacity (SECAP) estimated the number of colonoscopies that were performed and the number that could be performed. If a national screening program started in 2014, by 2024, approximately 47 million FIT procedures and 5.1 million colonoscopies would be needed annually to screen the eligible population with a program using FIT as the primary screening test; approximately 11 to 13 million colonoscopies would be needed annually to screen the eligible population with a colonoscopy-only screening program. According to the SECAP survey, an estimated 15 million colonoscopies were performed in 2012, and an additional 10.5 million colonoscopies could be performed. The estimated colonoscopy capacity is sufficient to screen 80% of the eligible US population with FIT, colonoscopy, or a mix of tests. Future analyses should take into account the geographic distribution of colonoscopy capacity. Cancer 2016;122:2479-86. © 2016 American Cancer Society. © 2016 American Cancer Society.

Storage characteristics of multiple-donor pooled red blood cells compared to single-donor red blood cell units.

PubMed

Mathur, Aabhas; Chowdhury, Raquibul; Hillyer, Christopher D; Mitchell, W Beau; Shaz, Beth H

2016-12-01

Each unit of blood donated is processed and stored individually resulting in variability in the amount of red blood cells (RBCs) collected, RBC properties, and the 24-hour posttransfusion RBC survivability. As a result, each unit differs in its ability to deliver oxygen and potentially its effects on the recipient. The goal of this study was to investigate the storage of pooled RBCs from multiple donors in comparison to control standard RBC units. Two units of irradiated, leukoreduced RBCs of same ABO, D, E, C, and K antigen phenotype were collected from each of five donors using apheresis. One unit from each donor was pooled in a 2-L bag and remaining units were used as controls. After being pooled, RBCs were separated in five bags and stored at 4°C along with the controls. Quality indexes were measured on Days 2, 14, and 28 for all the units. Adenosine triphosphate assays for both pooled and controls showed a slight decrease from Day 2 to Day 28 (pooled/control from 5.22/5.24 to 4.35/4.33 µmol/g hemoglobin [Hb]). 2,3-Diphosphoglycerate was successfully rejuvenated for all RBC units on Day 28 (pooled 11.46 µmol/g Hb; control 11.86 µmol/g Hb). The results showed a nonsignificant difference between pooled and control units, with a general trend of lower standard deviation for pooled units when compared to controls. Pooled units have reduced unit-to-unit variability. Future exploration of their immunogenicity is required before using pooled units for transfusion. © 2016 AABB.

Severe Acinetobacter baumannii Sepsis Is Associated With Elevation of Pentraxin 3

DTIC Science & Technology

2014-09-01

and disseminated intravascular coagulation have been reported fol- lowing fulminant A. baumannii sepsis, little is known about the protective host...ATCC 19606 and clinical isolates (CI) 77, 78, 79, 80, and 86. Interestingly, only CI strains 79, 80, and 86 induced PTX3 synthesis in murine J774a.1...that elevation of PTX3 is associated with fulminant disease during A. baumannii sepsis. Since the initial widespread use of antibiotics in hospitals

Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Saad, Khaled; Zahran, Asmaa M.; Elsayh, Khalid I.; Abdel-Rahman, Ahmed A.; Al-Atram, Abdulrahman A.; Hussein, Almontaser; El-Gendy, Yasmin G.

2017-01-01

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children…

Utilization of case presentations in medical microbiology to enhance relevance of basic science for medical students

PubMed Central

Chamberlain, Neal R.; Stuart, Melissa K.; Singh, Vineet K.; Sargentini, Neil J.

2012-01-01

Background Small-group case presentation exercises (CPs) were created to increase course relevance for medical students taking Medical Microbiology (MM) and Infectious Diseases (ID) Methods Each student received a unique paper case and had 10 minutes to review patient history, physical exam data, and laboratory data. Students then had three minutes to orally present their case and defend why they ruled in or out each of the answer choices provided, followed by an additional three minutes to answer questions. Results Exam scores differed significantly between students who received the traditional lecture-laboratory curriculum (Group I) and students who participated in the CPs (Group II). In MM, median unit exam and final exam scores for Group I students were 84.4% and 77.8%, compared to 86.0% and 82.2% for Group II students (P<0.018; P<0.001; Mann-Whitney Rank Sum Test). Median unit and final ID exam scores for Group I students were 84.0% and 80.0%, compared to 88.0% and 86.7% for Group II students (P<0.001; P<0.001). Conclusion Students felt that the CPs improved their critical thinking and presentation skills and helped to prepare them as future physicians. PMID:22435014

40 CFR 86.405-78 - Measurement system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Measurement system. 86.405-78 Section... 1978 and Later New Motorcycles, General Provisions § 86.405-78 Measurement system. (a) This subpart and subpart F have been written using System International (SI) units. SI units will be used to determine...

40 CFR 86.405-78 - Measurement system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Measurement system. 86.405-78 Section... 1978 and Later New Motorcycles, General Provisions § 86.405-78 Measurement system. (a) This subpart and subpart F have been written using System International (SI) units. SI units will be used to determine...

40 CFR 86.405-78 - Measurement system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Measurement system. 86.405-78 Section... 1978 and Later New Motorcycles, General Provisions § 86.405-78 Measurement system. (a) This subpart and subpart F have been written using System International (SI) units. SI units will be used to determine...

Complications of acucise endopyelotomy.

PubMed

Kim, F J; Herrell, S D; Jahoda, A E; Albala, D M

1998-10-01

Endoscopic management of ureteropelvic junction (UPJ) obstruction has a success rate of 80% to 86%. We have been performing a ureteral cutting balloon procedure under fluoroscopic control (Acucise endopyelotomy) for UPJ obstruction at Loyola University Medical Center since 1991. The overall success rate in 77 patients was 78%. All patients had a preoperative intravenous urogram or a retrograde pyelogram, but none had vascular imaging studies. Acucise endopyelotomy consisted of a posterolateral incision of the UPJ and placement of an endopyelotomy or double-J stent. Foley catheter placement at the end of the procedure demonstrated significant gross hematuria in three patients (4%). All three remained hemodynamically stable but with significant drops in postprocedure hemoglobin levels, which necessitated blood transfusion. Aggressive management included angiographic studies and embolization of lower-pole branching arteries in two patients (3%). One patient stopped bleeding after being given two units of blood. None of the patients required an open exploratory procedure. Although the risk of vascular injury is low with Acucise endopyelotomy, prolonged postoperative gross hematuria does mandate investigation and observation. Angiographic embolization appears to be the therapeutic modality of choice for patients with hemorrhagic complications after an Acucise endopyelotomy.

40 CFR 86.884-9 - Smoke measurement system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... extinction meter. ER06OC93.182 (b) Equipment. The following equipment shall be used in the system. (1... used to remove the exhaust from the test site. (2) Smokemeter (light extinction meter)—continuous... a remote control unit. (ix) Light extinction meters employing substantially identical measurement...

40 CFR 86.884-9 - Smoke measurement system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... extinction meter. ER06OC93.182 (b) Equipment. The following equipment shall be used in the system. (1... used to remove the exhaust from the test site. (2) Smokemeter (light extinction meter)—continuous... a remote control unit. (ix) Light extinction meters employing substantially identical measurement...

40 CFR 86.884-9 - Smoke measurement system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... extinction meter. ER06OC93.182 (b) Equipment. The following equipment shall be used in the system. (1... used to remove the exhaust from the test site. (2) Smokemeter (light extinction meter)—continuous... a remote control unit. (ix) Light extinction meters employing substantially identical measurement...

40 CFR 86.884-9 - Smoke measurement system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... extinction meter. ER06OC93.182 (b) Equipment. The following equipment shall be used in the system. (1... used to remove the exhaust from the test site. (2) Smokemeter (light extinction meter)—continuous... a remote control unit. (ix) Light extinction meters employing substantially identical measurement...

Results of a lay health education intervention to increase colorectal cancer screening among Filipino Americans: A cluster randomized controlled trial.

PubMed

Cuaresma, Charlene F; Sy, Angela U; Nguyen, Tung T; Ho, Reginald C S; Gildengorin, Ginny L; Tsoh, Janice Y; Jo, Angela M; Tong, Elisa K; Kagawa-Singer, Marjorie; Stewart, Susan L

2018-04-01

Filipino colorectal cancer (CRC) screening rates fall below Healthy People 2020 goals. In this study, the authors explore whether a lay health educator (LHE) approach can increase CRC screening among Filipino Americans ages 50 to 75 years in Hawai'i. A cluster randomized controlled trial from 2012 through 2015 compared an intervention, which consisted of LHEs delivering 2 education sessions and 2 telephone follow-up calls on CRC screening plus a CRC brochure versus an attention control, in which 2 lectures and 2 follow-up calls on nutrition and physical activity plus a CRC brochure were provided. The primary outcome was change in self-reported ever receipt of CRC screening at 6 months. Among 304 participants (77% women, 86% had > 10 years of residence in the United States), the proportion of participants who reported ever having received CRC screening increased significantly in the intervention group (from 80% to 89%; P = .0003), but not in the control group (from 73% to 74%; P = .60). After covariate adjustment, there was a significant intervention effect (odds ratio, 1.9; 95% confidence interval, 1.0-3.5). There was no intervention effect on up-to-date screening. This first randomized controlled trial for CRC screening among Hawai'i's Filipinos used an LHE intervention with mixed, but promising, results. Cancer 2018;124:1535-42. © 2018 American Cancer Society. © 2018 American Cancer Society.

Dare County Gunnery Range, North Carolina. Limited Surface Observations Climatic Summary (LISOCS). Parts A-F.

DTIC Science & Technology

1988-01-01

AIR wEATHER SERVICE/MAC--) STATION NUMBER: ?4695C STATIOK NAME: DARE COUNTY GUNNERY RANGE NC PERIOD OF PECORD: 7887 MONTH: JAN HOURSILSTi: ISO -1700...25D01 776 89.7 87.1 88.2 88.2 88.2 88.2 88.2 88.2 8.2 88.2 88:2 88.2 88.2 88.2 C GE 27001 78.8 85.9 88.2 89.4 89.4 89.9 89.4 89.4 90.6 97.6 93.6 90.6...78.6 81 .9 83. 4 83.4 85. 1 85 .7 86. 7 86.7 86.7 86.9 87.8 C)GE 27001 5 1.9 65.1 73.8 80.4 80.6 83 .9 85. 3 65.3 87.3 87.8 87.8 88.8 88.8 89.2 90. 1 G

40 CFR 86.097-9 - Emission standards for 1997 and later model year light-duty trucks.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86... 0.32 4.4 0.08 Methanol 0-3750 0.25 3.4 0.4 0.08 Methanol 3751-5750 0.32 4.4 0.7 0.08 Natural Gas 0....10 Methanol 0-3750 0.80 0.31 4.2 0.6 0.10 Methanol 3751-5750 0.80 0.40 5.5 0.97 0.10 Natural Gas 0...

40 CFR 86.097-9 - Emission standards for 1997 and later model year light-duty trucks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86... 0.32 4.4 0.08 Methanol 0-3750 0.25 3.4 0.4 0.08 Methanol 3751-5750 0.32 4.4 0.7 0.08 Natural Gas 0....10 Methanol 0-3750 0.80 0.31 4.2 0.6 0.10 Methanol 3751-5750 0.80 0.40 5.5 0.97 0.10 Natural Gas 0...

Why Are Chinese Mothers More Controlling than American Mothers? "My Child Is My Report Card"

ERIC Educational Resources Information Center

Ng, Florrie Fei-Yin; Pomerantz, Eva M.; Deng, Ciping

2014-01-01

Chinese parents exert more control over children than do American parents. The current research examined whether this is due in part to Chinese parents' feelings of worth being more contingent on children's performance. Twice over a year, 215 mothers and children (M[subscript age] = 12.86 years) in China and the United States (European and African…

Construction and Testing of an 80C86 Based Communications Controller for the Petite Amateur Navy Satellite (PANSAT)

DTIC Science & Technology

1990-12-01

S) Naval Postgraduate School 6a. NAME OF PERFORMING ORGANIZATION 6b OFFICE SYMBOL 7a NAME OF MONITORING ORGANIZATION (if applicable ) Code 33 6c...FUNDING/SPONSORING Bb. OFFICE SYMBOL 9. PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (If applicable ) 8c. ADDRESS (City, State, and ZIP Code...system’s individual components. Then one derives the overall system reliability from that information, using a simple mathematical model, to be

Effect of standardized extract of Bacopa monnieri (CDRI-08) on testicular functions in adult male mice.

PubMed

Patel, Shishir Kumar; Singh, Shilpi; Singh, Hemant Kumar; Singh, Shio Kumar

2017-02-02

Bacopa monnieri (BM) has been used in India since the time of Rig-Veda for augmentation of learning, memory, brain health etc. The memory augmenting effect of BM is well documented. CDRI-08 is a standardized extract of Bacopa monnieri, but its effect on the male reproductive health has not been investigated. Therefore, the aim of the present study was to examine the effect of CDRI-08 administration on the male reproductive organs with special emphasis on testis in adult mice. CDRI-08, containing at least 55% bacosides (the major constituent of BM), was investigated for its effect on testicular functions in adult Parkes (P) mice. A suspension of CDRI-08 was orally administered in doses of 40 and 80mgkg -1 body weight day -1 for 28 days and various male reproductive end points were evaluated. Compared to control, CDRI-08 treatment caused a significant increase (p<0.05) in spermatogenic cell density (germinal epithelial height: control, 55.03±4.22 vs 40mg, 67.15±2.65 and 80mg, 69.93±3.76; and tubular diameter: control, 206.55±2.62 vs 80mg, 253.23±12.19), PCNA index (control, 59.85±2.09 vs 40mg, 82.17±1.56 and 80mg, 84.05±3.51) and in steroidogenic indices in the testis, and in sperm viability (control, 0.67±0.010 vs 80mg, 0.80±0.04) in cauda epididymidis of the treated mice. On the other hand, however, the same treatment caused a significant decrease (p<0.05) in abnormal sperm morphology (control, 21.72±1.06 vs 40mg, 10.63±1.50 and 80mg, 15.86±0.87) in cauda epididymidis, and in lipid peroxidation level in testis of the treated mice compared to controls. The results suggest that treatment with CDRI-08 extract improves sperm quality, and spermatogenic cell density and steroidogenic indices in the testis of P mice. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10.

PubMed

Mazzoccoli, Luciano; Cadoso, Silvia H; Amarante, Giovanni W; de Souza, Marcus V N; Domingues, Robert; Machado, Marco A; de Almeida, Mauro V; Teixeira, Henrique C

2012-07-01

Thalidomide is used to treat a variety of diseases including erythema nodosum leprosum, an inflammatory complication of leprosy. However, this drug has severe teratogenic activity and novel thalidomide analogues might be used to treat diseases without this severe side effect. A series of diamine compounds containing two hydrolyzed phthalimide units were chosen as analogues of thalidomide and evaluated regarding their capacity to regulate the production of molecules involved in inflammatory responses. TNF-α, IL-12 and IL-10 production, and the expression of CD80 and CD86 were investigated in LPS plus IFN-γ-stimulated J774A.1 cells by ELISA and flow cytometry, respectively. The expression of TNF-α and IL-10 mRNA was analyzed by real time RT-PCR. TNF-α, IL-6, IFN-γ, CXCL9 and CXCL10 production by human peripheral blood mononuclear cells (PBMC) were evaluated by flow cytometry. Compounds 3, 6 and 9 greatly inhibited TNF-α and IL-12 production while enhancing IL-10. In addition, CD80 expression was inhibited, but not CD86. The compounds inhibited TNF-α production by PBMC more than thalidomide and also had an inhibitory effect on the production of IL-6, IFN-γ, CXCL9 and CXCL10. Levels of mRNA for TNF-α were reduced after treatment with the compounds, suggesting post- transcriptional effects. The compounds had no effect on cell viability. Our results indicate that the novel diamine compounds 3, 6 and 9 inhibit critical pro-inflammatory cytokines and stimulate IL-10, which make them attractive candidate drugs for the treatment of certain inflammatory conditions and cancer. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Comparison of psychodrug prescription patterns in patients diagnosed with bipolar disorder and addiction.

PubMed

Barral, Diego; Barral, Fátima; Cruz, Nuria; Molina, Juan D; Sánchez, Victoria; Rosique, Teresa

2016-11-01

To describe if there are differences in the prescription of psychodrug at discharge between bipolar disorder patients with or without addiction. We review all the psychotropic drugs dispensed to inpatients of a brief hospitalization psychiatric unit diagnosed as having bipolar disorder at time of discharge. We recluted 225 patients over 18 years old on their last manic episode, between the year 2000 and 2010. We classify them according to the comorbid presence or not of a substance abuse or dependence disorder. Prevalence of addiction was 24%. We found no differences between groups in the number of psychotropic drugs prescribed at discharge. The prescription pattern of mood stabilizers and benzodiazepines was similar in both groups. We detect differences in the total daily dose of antipsychotic, expressed as risperidone equivalents (5.86 ± 4.62 mg in addictions group versus 4.67 ± 3.20 mg in control group, p=0.042) and in the total daily dose of biperideno (4.80 ± 1.78 mg in addictions group versus 3.20 ± 1.03 mg in the control group, p=0.044). Contrary to our expectations, both groups were similar in psychopharmacological prescription patterns at discharge. However, those patients with substance abuse disorder had higher doses of antipsychotics and higher dose biperiden at discharge.

Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study.

PubMed

Huang, Chunyu; Zhang, Hongzhan; Chen, Xian; Diao, Lianghui; Lian, Ruochun; Zhang, Xu; Hu, Lina; Zeng, Yong

2016-10-01

Dendritic cells (DCs) have been reported to play an important role in pregnancy. However, the role of DCs in recurrent pregnancy loss (RPL) has not been investigated well. Forty-three women affected by RPL and 16 fertile controls were recruited from June 2013 to December 2014. The peripheral blood DCs subsets, including myeloid DCs (mDCs) and plasmacytoid DCs (pDCs), the levels (%) of CD80(+) , CD86(+) , and CD200(+) DCs were analyzed using flow cytometry. The levels of total DCs, mDCs, and CD86(+) DCs were significantly higher (all P<.05); however, the level of CD200(+) DCs in the RPL group was significantly lower than that of the control group (P<.05). The logistical regression analyses showed that the elevated level of mDCs was significantly associated with RPL after adjustment for age (OR: 1.14, 95% CI, 1.01-1.29, P<.05). The elevated level of mDCs was significantly associated with RPL, which might lead to the intervention of targeted immunosuppression in women with RPL. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Randomized Controlled Trial on Effect of Intermittent Early Versus Late Kangaroo Mother Care on Human Milk Feeding in Low-Birth-Weight Neonates.

PubMed

Jayaraman, Dhaarani; Mukhopadhyay, Kanya; Bhalla, Anil Kumar; Dhaliwal, Lakhbir Kaur

2017-08-01

Breastfeeding at discharge among sick low-birth-weight (LBW) infants is low despite counseling and intervention like kangaroo mother care (KMC). Research aim: The aim was to study the effects of early initiation of KMC on exclusive human milk feeding, growth, mortality, and morbidities in LBW neonates compared with late initiation of KMC during the hospital stay and postdischarge. A randomized controlled trial was conducted in level 2 and 3 areas of a tertiary care neonatal unit over 15 months. Inborn neonates weighing 1 to 1.8 kg and hemodynamically stable were randomized to receive either early KMC, initiated within the first 4 days of life, or late KMC (off respiratory support and intravenous fluids). Follow-up was until 1 month postdischarge. Outcomes were proportion of infants achieving exclusive human milk feeding and direct breastfeeding, growth, mortality and morbidities during hospital stay, and postdischarge feeding and KMC practices until 1 month. The early KMC group ( n = 80) achieved significantly higher exclusive human milk feeding (86% vs. 45%, p < .001) and direct breastfeeding (49% vs. 30%, p = .021) in hospital and almost exclusive human milk feeding (73% vs. 36%, p < .001) until 1 month postdischarge than the late KMC group ( n = 80). The incidence of apnea (11.9% vs. 20%, p = .027) and recurrent apnea requiring ventilation (8.8% vs. 15%, p = .02) were significantly reduced in the early KMC group. There was no significant difference in mortality, morbidities, and growth during the hospital stay and postdischarge. Early KMC significantly increased exclusive human milk feeding and direct breastfeeding in LBW infants.

Determination of Cardiac Output and Ejection Fraction with the Dual Cardiac Probe

PubMed Central

Cardenas, Carlos G.; Depuey, E. Gordon; Thompson, Wayne L.; Garcia, Efrain; Burdine, John A.

1983-01-01

Cardiac output and left ventricular ejection fraction were determined noninvasively at the bedside in 26 patients by using a dual scintillation probe. The probe is a nonimaging detector that records a high frequency time-activity curve of the passage of an intravenously injected radioactive bolus through the heart. Results were correlated with ejection fraction measured by biplane cineangiography (r = 0.80) and cardiac output determined by green dye dilution (R = 0.86). It is concluded that the dual probe provides an accurate noninvasive means of measuring these parameters, and that it may be particularly applicable to serial measurements in patients in the intensive care unit. Images PMID:15227151

Source Localization in a Cognitive Radio Environment Consisting of Frequency and Spatial Mobility

DTIC Science & Technology

2011-12-01

are designed to track position over time using a wireless RF sensor network, such as Kalman filtering [13]. 74 THIS PAGE INTENTIONALLY LEFT BLANK...Radio,” Proceedings of the IEEE, vol. 97, no. 4, pp. 612–625, Apr. 2009. 80 [12] J. B. Bernthal, T. X. Brown , D. N. Hatfield, D. C. Sicker, P. A... Kalman Filtering in Wireless Sensor Networks,” IEEE Control Systems, vol. 30, no. 2, pp. 66–86, April 2010. [14] J. Nemeroff, L. Garcia, D

46 CFR 130.470 - Fire alarms.

Code of Federal Regulations, 2014 CFR

2014-10-01

... fire detector and control unit must be of a type specifically approved by the Commandant (CG-ENG). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

46 CFR 130.470 - Fire alarms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... fire detector and control unit must be of a type specifically approved by the Commandant (CG-521). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

46 CFR 130.470 - Fire alarms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... fire detector and control unit must be of a type specifically approved by the Commandant (CG-521). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

46 CFR 130.470 - Fire alarms.

Code of Federal Regulations, 2013 CFR

2013-10-01

... fire detector and control unit must be of a type specifically approved by the Commandant (CG-ENG). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

46 CFR 130.470 - Fire alarms.

Code of Federal Regulations, 2012 CFR

2012-10-01

... fire detector and control unit must be of a type specifically approved by the Commandant (CG-ENG). (b) No fire-alarm circuit for the engine room may contain a fire detector for any other space. (c) The number and placement of fire detectors must be approved by the cognizant OCMI. [CGD 82-004 and CGD 86-074...

Thematic accuracy of the NLCD 2001 land cover for the conterminous United States

USGS Publications Warehouse

Wickham, J.D.; Stehman, S.V.; Fry, J.A.; Smith, J.H.; Homer, Collin G.

2010-01-01

The land-cover thematic accuracy of NLCD 2001 was assessed from a probability-sample of 15,000 pixels. Nationwide, NLCD 2001 overall Anderson Level II and Level I accuracies were 78.7% and 85.3%, respectively. By comparison, overall accuracies at Level II and Level I for the NLCD 1992 were 58% and 80%. Forest and cropland were two classes showing substantial improvements in accuracy in NLCD 2001 relative to NLCD 1992. NLCD 2001 forest and cropland user's accuracies were 87% and 82%, respectively, compared to 80% and 43% for NLCD 1992. Accuracy results are reported for 10 geographic regions of the United States, with regional overall accuracies ranging from 68% to 86% for Level II and from 79% to 91% at Level I. Geographic variation in class-specific accuracy was strongly associated with the phenomenon that regionally more abundant land-cover classes had higher accuracy. Accuracy estimates based on several definitions of agreement are reported to provide an indication of the potential impact of reference data error on accuracy. Drawing on our experience from two NLCD national accuracy assessments, we discuss the use of designs incorporating auxiliary data to more seamlessly quantify reference data quality as a means to further advance thematic map accuracy assessment.

Preventing patient-to-worker violence in hospitals: outcome of a randomized controlled intervention

PubMed Central

Arnetz, Judith E.; Hamblin, Lydia; Russell, Jim; Upfal, Mark J.; Luborsky, Mark; Janisse, James; Essenmacher, Lynnette

2016-01-01

Objective To evaluate the effects of a randomized controlled intervention on the incidence of patient-to-worker (Type II) violence and related injury in hospitals. Methods Forty-one units across 7 hospitals were randomized into intervention (n=21) and control (n=20) groups. Intervention units received unit-level violence data to facilitate development of an action plan for violence prevention; no data were presented to control units. Main outcomes were rates of violent events and injuries across study groups over time. Results Six months post-intervention, incident rate ratios of violent events were significantly lower on intervention units compared to controls (IRR 0.48, 95% CI 0.29-0.80). At 24 months, the risk for violence-related injury was lower on intervention units, compared to controls (IRR 0.37, 95% CI 0.17-0.83). Conclusion This data-driven, worksite-based intervention was effective in decreasing risks of patient-to-worker violence and related injury. PMID:28045793

Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity.

PubMed

de Haar, Colin; Kool, Mirjam; Hassing, Ine; Bol, Marianne; Lambrecht, Bart N; Pieters, Raymond

2008-05-01

The adjuvant activity of air pollution particles on allergic airway sensitization is well known, but the cellular mechanisms underlying this adjuvant potential are not clear. We sough to study the role of dendritic cells and the costimulatory molecules CD80 and CD86 in the adjuvant activity of ultrafine carbon black particles (CBP). The proliferation of CFSE-labeled DO11.10 CD4 cells was studied after intranasal exposure to particles and ovalbumin (OVA). Next the frequency of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells and their expression of CD80 and CD86 were studied in the peribronchial lymph nodes (PBLNs). The expression of costimulatory molecules was also studied on bone marrow-derived mDCs after exposure to CBPs in vitro, and the importance of costimulation in CBP adjuvant activity was assessed by using CD80/CD86-deficient mice or cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-Ig in vivo. Our data show that CBPs plus OVA caused proliferation of DO11.10 CD4 cells and high levels of cytokine production in the PBLNs. Furthermore, the combined CBP plus OVA exposure increased the number of mDCs and expression of costimulatory molecules in the PBLNs. In addition, CBPs upregulated the expression of CD80/CD86 molecules on dendritic cells in vitro, which are necessary for the particle adjuvant effects in vivo. Together this study shows the importance of dendritic cells and costimulation in particle adjuvant activity. Furthermore, we show for the first time that CBPs can also directly induce maturation of dendritic cells.

Mesure du Deplacement de Frequence au Maximum de la Raie P20 un Laser CO2 a Ondes Guidees (Measurement of the Frequency Shift at the Peak of the P20 Line of a CO2 Waveguide Laser),

DTIC Science & Technology

1986-06-01

VINCENT ET AL . UNCLASSIFIED JUN 86 DREV-4419/86 F/G 28/5 NI iiiimEEmmomEEI 111-25 W1.6 * AD-A170 318 WIAI iLL. f.Pf I)E V jP ’)MEN, fFIlA 4 H l t A 4...triangulaires Hewlett-Packard, modale 3310B (OSC. 1), dont le signal est amplifi6 par un amplificateur haute ten- sion Lansing, modale 80.315 (PZT AL ...CLASSIFICATION 3 PT AL O.G AL CONTROLE * OSC’ I V-~ ----- GAZ 05; C. - - SPEC-. I -_ _ - - 0 G. -ET SYNC 2 REF. - L - BP -- CSPEC 2 - DET. PYR1C - " VDET

40 CFR 86.132-96 - Vehicle preconditioning.

Code of Federal Regulations, 2010 CFR

2010-07-01

... obtained from § 86.129-80. (f)(1) Gasoline- and methanol-fueled vehicles. After completion of the... gasoline- and methanol-fueled vehicles shall be removed during any period that the vehicle is parked... area and the following operations performed. (b)(1) Gasoline- and Methanol-Fueled Vehicles. Drain the...

40 CFR 86.132-96 - Vehicle preconditioning.

Code of Federal Regulations, 2011 CFR

2011-07-01

... obtained from § 86.129-80. (f)(1) Gasoline- and methanol-fueled vehicles. After completion of the... gasoline- and methanol-fueled vehicles shall be removed during any period that the vehicle is parked... area and the following operations performed. (b)(1) Gasoline- and Methanol-Fueled Vehicles. Drain the...

Prima facie evidence that a phytocystatin for transgenic plant resistance to nematodes is not a toxic risk in the human diet.

PubMed

Atkinson, Howard J; Johnston, Katherine A; Robbins, Mark

2004-02-01

A protein-engineered rice cystatin (OcIDeltaD86) provides transgenic, partial crop resistance to plant nematodes. This study determined whether its oral uptake has adverse effects on male Sprague-Dawley rats when they are administered by oral gavage 0.1-10 mg OcIDeltaD86/kg body weight daily for 28 d. Body weight and water and food intakes were unaltered for most of the study. The only significant changes in fresh weight of nine organs were for the liver (4% decrease; P < 0.05) and the empty cecum (14% increase; P < 0.05) at the two lowest doses and the highest dose of OcIDeltaD86, respectively. No abnormalities in either organ were detected by histochemistry. There were no changes in the urine or in hematological variables measured, and blood serum revealed no dose-dependent responses for any of 17 variables measured. OcIDeltaD86 was degraded by boiling with a 50% loss of its inhibition of papain after 9.2 +/- 8.0 min. It also showed >95% loss of such inhibition after 15 s in simulated gastric fluid. The results suggest that the no effect level (NOEL) for OcIDeltaD86 is >10 mg/(kg. d). This provides a range of dietary exposure >200-2000 fold depending upon the promoter used to control its expression in potato.

A negative regulatory role in mouse cardiac transplantation for a splice variant of CD80.

PubMed

Bugeon, Laurence; Wong, Kenneth K; Rankin, Alasdair M; Hargreaves, Roseanna E G; Dallman, Margaret J

2006-11-27

Members of the B7 costimulatory protein family (CD80 and CD86) play a determining role in allograft rejection. Both CD80 and CD86 have naturally occurring splice variants whose roles in transplantation are unknown. Full length CD80 has two immunoglobulin (Ig)-like domains in the extracellular portion, IgC and IgV. In mouse, the isoform IgV-CD80 lacks the IgC-like domain. Here we analyzed the role of mouse IgV-CD80 in heart allograft rejection and search for equivalent splice variants in human. Mice made deficient for full-length CD80 but which retain expression of the shorter IgV-CD80 (CD80 mice) were used as donor or recipient of a heart allograft. Recipient animals were untreated or pretreated with alloantigen expressing cells and/or treated with CD80 and CTLA4 monoclonal antibodies (mAbs). Recipients expressing IgV-CD80 but not full length CD80 exhibited a slight prolongation in survival of either wild-type (Wt) or CD80 grafts. More dramatically, CD80 animals pretreated with donor alloantigen exhibited permanent graft survival, whereas their Wt counterparts rejected their grafts with a median survival of 24 days. This prolonged survival was due to the expression of IgV-CD80 in recipients since treatment with CD80 mAb abrogated the beneficial effect observed. We identified and report here a similar isoform of CD80 from human cDNA encoding a putative soluble, IgV-containing protein. IgV-CD80 bearing recipients show enhanced allograft survival especially after donor alloantigen pretreatment. This together with data from other species suggests that regulation delivered by splice variants of CD80 significantly modulates immunity and may be common across the species.

Neuroretinal alterations in the early stages of diabetic retinopathy in patients with type 2 diabetes mellitus.

PubMed

Carpineto, P; Toto, L; Aloia, R; Ciciarelli, V; Borrelli, E; Vitacolonna, E; Di Nicola, M; Di Antonio, L; Mastropasqua, R

2016-05-01

PurposeTo study neuroretinal alterations in patients affected by type 2 diabetes with no diabetic retinopathy (DR) or mild nonproliferative diabetic retinopathy (NPDR) and without any sign of diabetic macular edema.Patients and methodsIn total, 150 type 2 diabetic patients with no (131 eyes) or mild NPDR (19 eyes) and 50 healthy controls were enrolled in our study. All underwent a complete ophthalmologic examination, including Spectral-Domain optical coherence tomography (SD-OCT). Ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thickness values were calculated after automated segmentation of SD-OCT scans.ResultsMean best-corrected visual acuity was 0.0±0.0 LogMAR in all the groups. Mean GC-IPL thickness was 80.6±8.1 μm in diabetic patients and 85.3±9.9 μm in healthy controls, respectively (P=0.001). Moreover, evaluating the two different diabetic groups, GC-IPL thickness was 80.7±8.1 μm and 79.7±8.8 μm in no-DR and mild-NPDR group (P=0.001 and P=0.022 compared with healthy controls, respectively). Average RNFL thickness was 86.1±10.1 μm in diabetes patients and 91.2±7.3 μm in controls, respectively (P=0.003). RNFL thickness was 86.4±10.2 μm in no-DR group and 84.1±9.4 μm in mild-NPDR group (P=0.007 and P=0.017 compared with healthy controls, respectively).ConclusionWe demonstrated a significantly reduced GC-IPL and RNFL thickness values in both no-DR and mild-NPDR groups compared with healthy controls. These data confirmed neuroretinal alterations are early in diabetes, preceding microvascular damages.

Lactosucrose attenuates intestinal inflammation by promoting Th2 cytokine production and enhancing CD86 expression in colitic rats.

PubMed

Zhou, Yan; Ruan, Zheng; Zhou, Xiaoli; Huang, Xiaoliu; Li, Hua; Wang, Ling; Zhang, Cui; Deng, Zeyuan; Wu, Guoyao; Yin, Yulong

2015-01-01

Some oligosaccharides have immunoregulatory and anti-inflammatory functions in the intestine. This study investigated the immunoregulatory effect of lactosucrose (LS) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitic rats. Alkaline phosphatase activity was increased but myeloperoxidase activity was decreased in the LS-TNBS group, as compared with the TNBS group (colitis rats without receiving LS). LS supplementation stimulated IL-4 and IL-10 production, while up-regulating CD86 expression in dendritic cells. LS supplementation reduced the ratio of CD80/CD86 and the ratio of IFN-γ/IL-4 compared to the TNBS group. Moreover, IFN-γ was significantly correlated with CD80 (r = 0.764, p < 0.01), whereas IL-4 was significantly correlated with CD86 (r = 0.489, p < 0.05). These results indicated that LS attenuated colitis by promoting the production of Th2-type cytokines and rebalancing the ratio of Th1/Th2 and that enhanced IL-4 production is correlated with enhanced CD86 expression in the gut. Therefore, LS is a functional food for patients with inflammatory bowel disease.

Separation of tartronic and glyceric acids by simulated moving bed chromatography.

PubMed

Coelho, Lucas C D; Filho, Nelson M L; Faria, Rui P V; Ferreira, Alexandre F P; Ribeiro, Ana M; Rodrigues, Alírio E

2018-08-17

The SMB unit developed by the Laboratory of Separation and Reaction Engineering (FlexSMB-LSRE ® ) was used to perform tartronic acid (TTA) and glyceric acid (GCA) separation and to validate the mathematical model in order to determine the optimum operating parameters of an industrial unit. The purity of the raffinate and extract streams in the experiments performed were 80% and 100%, respectively. The TTA and GCA productivities were 79 and 115 kg per liter of adsorbent per day, respectively and only 0.50 cubic meters of desorbent were required per kilogram of products. Under the optimum operating conditions, which were determined through an extensive simulation study based on the mathematical model developed to predict the performance of a real SMB unit, it was possible to achieve a productivity of 86 kg of TTA and 176 kg of GCA per cubic meter of adsorbent per day (considering the typical commercial purity value of 97% for both compounds) with an eluent consumption of 0.30 cubic meters per kilogram of products. Copyright © 2018 Elsevier B.V. All rights reserved.

38 CFR 4.25 - Combined ratings table.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 40 46 53 60 67 73 80 87 93 34 41 47 54 60 67 74 80 87 93 35 42 48 55 61 68 74 81 87 94 36 42 49 55 62 68 74 81 87 94 37 43 50 56 62 69 75 81 87 94 38 44 50 57 63 69 75 81 88 94 39 45 51 57 63 70 76 82... 72 77 81 86 91 95 54 59 63 68 72 77 82 86 91 95 55 60 64 69 73 78 82 87 91 96 56 60 65 69 74 78 82 87...

38 CFR 4.25 - Combined ratings table.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 40 46 53 60 67 73 80 87 93 34 41 47 54 60 67 74 80 87 93 35 42 48 55 61 68 74 81 87 94 36 42 49 55 62 68 74 81 87 94 37 43 50 56 62 69 75 81 87 94 38 44 50 57 63 69 75 81 88 94 39 45 51 57 63 70 76 82... 72 77 81 86 91 95 54 59 63 68 72 77 82 86 91 95 55 60 64 69 73 78 82 87 91 96 56 60 65 69 74 78 82 87...

38 CFR 4.25 - Combined ratings table.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 40 46 53 60 67 73 80 87 93 34 41 47 54 60 67 74 80 87 93 35 42 48 55 61 68 74 81 87 94 36 42 49 55 62 68 74 81 87 94 37 43 50 56 62 69 75 81 87 94 38 44 50 57 63 69 75 81 88 94 39 45 51 57 63 70 76 82... 72 77 81 86 91 95 54 59 63 68 72 77 82 86 91 95 55 60 64 69 73 78 82 87 91 96 56 60 65 69 74 78 82 87...

38 CFR 4.25 - Combined ratings table.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 40 46 53 60 67 73 80 87 93 34 41 47 54 60 67 74 80 87 93 35 42 48 55 61 68 74 81 87 94 36 42 49 55 62 68 74 81 87 94 37 43 50 56 62 69 75 81 87 94 38 44 50 57 63 69 75 81 88 94 39 45 51 57 63 70 76 82... 72 77 81 86 91 95 54 59 63 68 72 77 82 86 91 95 55 60 64 69 73 78 82 87 91 96 56 60 65 69 74 78 82 87...

38 CFR 4.25 - Combined ratings table.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 40 46 53 60 67 73 80 87 93 34 41 47 54 60 67 74 80 87 93 35 42 48 55 61 68 74 81 87 94 36 42 49 55 62 68 74 81 87 94 37 43 50 56 62 69 75 81 87 94 38 44 50 57 63 69 75 81 88 94 39 45 51 57 63 70 76 82... 72 77 81 86 91 95 54 59 63 68 72 77 82 86 91 95 55 60 64 69 73 78 82 87 91 96 56 60 65 69 74 78 82 87...

High PD-L1/CD86 MFI ratio and IL-10 secretion characterize human regulatory dendritic cells generated for clinical testing in organ transplantation.

PubMed

Zahorchak, Alan F; Macedo, Camila; Hamm, David E; Butterfield, Lisa H; Metes, Diana M; Thomson, Angus W

2018-01-01

Human regulatory dendritic cells (DCreg) were generated from CD14 immunobead-purified or elutriated monocytes in the presence of vitamin D3 and IL-10. They exhibited similar, low levels of costimulatory CD80 and CD86, but comparatively high levels of co-inhibitory programed death ligand-1 (PD-L1) and IL-10 production compared to control immature DC (iDC). Following Toll-like receptor 4 ligation, unlike control iDC, DCreg resisted phenotypic and functional maturation and further upregulated PD-L1:CD86 expression. Whereas LPS-stimulated control iDC (mature DC; matDC) secreted pro-inflammatory tumor necrosis factor but no IL-10, the converse was observed for LPS-stimulated DCreg. DCreg weakly stimulated naïve and memory allogeneic CD4 + and CD8 + T cell proliferation and IFNγ, IL-17A and perforin/granzyme B production in MLR. Their stimulatory function was enhanced however, by blocking PD-1 ligation. High-throughput T cell receptor (TCR) sequencing revealed that, among circulating T cell subsets, memory CD8 + T cells contained the most alloreactive TCR clonotypes and that, while matDC expanded these alloreactive memory CD8 TCR clonotypes, DCreg induced more attenuated responses. These findings demonstrate the feasibility of generating highly-purified GMP-grade DCreg for systemic infusion, their influence on the alloreactive T cell response, and a key mechanistic role of the PD1 pathway. Copyright © 2017 Elsevier Inc. All rights reserved.

Use of non-opioid analgesics as adjuvants to opioid analgesia for cancer pain management in an inpatient palliative unit: does this improve pain control and reduce opioid requirements?

PubMed

Shinde, Shivani; Gordon, Pamela; Sharma, Prashant; Gross, James; Davis, Mellar P

2015-03-01

Cancer pain is complex, and despite the introduction of the WHO cancer pain ladder, few studies have looked at the prevalence of adjuvant medication use in an inpatient palliative medicine unit. In this study, we evaluate the use of adjuvant pain medications in patients admitted to an inpatient palliative care unit and whether their use affects pain scores or opiate dosing. In this retrospective observational study, patients admitted to the inpatient palliative care unit over a 3-month period with a diagnosis of cancer on opioid therapy were selected. Data pertaining to demographics, diagnosis, oral morphine dose equivalent of the opioid at the time of discharge, adjuvant analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and pain scores as reported by nurses and physicians were collected. Seventy-seven patients were eligible over a 3-month period, out of which 65 (84 %) were taking an adjuvant medication. The most commonly prescribed adjuvant was gabapentin (70 %). Fifty-seven percent were taking more than one adjuvant. There were more women in the group receiving adjuvants (57 vs. 17%, p = 0.010). Those without adjuvants compared with those on adjuvants did not have worse pain scores on discharge as reported by physicians (0.8 ± 0.8 vs. 1.0 ± 0.7, p = 0.58) or nurses (2.0 ± 2.7 vs. 2.1 ± 2.6, p = 0.86). There was no difference in morphine equivalent doses of the opioid in both groups (median (min, max); 112 (58, 504) vs. 200 (30, 5,040)) at the time of discharge; 75-80 % of patients had improvement in pain scores as measured by a two-point reduction in numerical rating scale (NRS). This study shows that adjuvant medications are commonly used for treating pain in patients with cancer. More than half of study population were on two adjuvants or an adjuvant plus NSAID along with an opioid. We did not demonstrate any benefit in terms of improved pain scores or opioid doses with adjuvants, but this could reflect confounding variables and physician choice. Larger prospective studies are needed to define the opioid-sparing effects of adjuvants. Adjuvant agents are used in over 80 % of those treated for cancer pain.

Career pathways and destinations 18 years on among doctors who qualified in the United Kingdom in 1977: postal questionnaire survey.

PubMed

Davidson, J M; Lambert, T W; Goldacre, M J

1998-11-21

To determine the career destinations, by 1995, of doctors who qualified in the United Kingdom in 1977; the relation between their destinations and early career choice; and their intentions regarding retirement age. Postal questionnaire. United Kingdom. All (n=3135) medical qualifiers of 1977. Current employment; year by year trends in the percentage of doctors who worked in the NHS, in other medical posts in the United Kingdom, abroad, in non-medical posts, outside medicine, and in part time work; intentions regarding retirement age. After about 12 years the distribution of respondents by type of employment, and, for women, the percentage of doctors in part time rather than full time medical work, had stabilised. Of all 2997 qualifiers from medical schools in Great Britain, 2399 (80.0% (95% confidence interval 79.5% to 80.6%)) were working in medicine in the NHS in Great Britain 18 years after qualifying. Almost half the women (318/656) worked in the NHS part time. Of 1714 doctors in the NHS, 1125 intended to work in the NHS until normal retirement age, 392 did not, and 197 were undecided. Of the 1548 doctors for whom we had sufficient information, career destinations at 18 years matched the choices made at 1, 3, and 5 years in 58.9% (912), 78.2% (1211), and 86.6% (1341) of cases respectively. Planning for the medical workforce needs to be supported by information about doctors' career plans, destinations, and whole time equivalent years of work. Postgraduate training needs to take account of doctors' eventual choice of specialty (and the timing of this choice).

Variations in incubator temperature and humidity management: a survey of current practice.

PubMed

Deguines, C; Décima, P; Pelletier, A; Dégrugilliers, L; Ghyselen, L; Tourneux, P

2012-03-01

To describe and assess routine procedures and practices for incubator temperature and humidity management in France in 2009. A questionnaire was sent to all the 186 neonatal care units in France. The questionnaire return rate was 86%. Seventy-five per cent of the units preferred skin servo-control to air temperature control in routine practice. Air temperature control was mainly used for infants with a gestational age of more than 28 weeks and aged over 7 days of life. In general, thermal management decisions did not depend on the infant's age but were based on a protocol applied specifically by each unit. All units humidified the incubator air, but there was a large difference between the lowest and highest reported humidity values (45% and 100% assumed to be a maximal value, respectively). More than 65% of the units used a fixed humidity value, rather than a variable, protocol-derived value. We observed large variations in incubator temperature and humidity management approaches from one neonatal care unit to another. There is a need for more evidence to better inform practice. A task force should be formed to guide clinical practice. © 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.

[A novel ship-borne positive pressure solid phase extraction device to enrich organo chlorinated and pyrethroid pesticides in seawater].

PubMed

Ye, Jianglei

2017-09-08

A novel solid phase extraction (SPE) device driven by positive pressure was developed instead of negative pressure from a vacuum pump, in order to enrich organo chlorinated and pyrethroid pesticides in seawater. The water sampling bottles and the pipelines which touch water samples were made of plastic material without chlorine. In order to ensure the sealing and firmness, the whole device were tightened with nut and bolt. The inner pressure (0.1-0.3 MPa) in the water sampling bottle was provided by the small air pump (powered by 12 V cell) controlled by a microprogrammed control unit (MCU) and pressure sensor to keep the water flow rate (4.0-6.0 mL/min). The pre-conditioned SPE column can be used for the enrichment of pesticides within four weeks, and the loaded SPE column can be eluted for detection within six weeks with recoveries greater than 80%. The linearity of the method was good with the correlation coefficient more than 0.9. The limits of quantification (LOQs) were 0.8-6 ng/L. The recoveries of the pesticides at three spiked levels (3 parallel samples) were 86.1%-95.5% with the relative standard deviations less than 10%. The benzene hexachlorides (BHCs) and dichloro-diphenyl-trichloroethanes (DDTs) were detected in seawater samples. The device has good application in enriching organo chlorinated and pyrethroid pesticides in seawater.

50 CFR 86.120 - What is the Comprehensive National Assessment?

Code of Federal Regulations, 2012 CFR

2012-10-01

... Assessment? 86.120 Section 86.120 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT... INFRASTRUCTURE GRANT (BIG) PROGRAM Completing the Comprehensive National Assessment § 86.120 What is the Comprehensive National Assessment? The Comprehensive National Assessment is a national report integrating the...

50 CFR 86.120 - What is the Comprehensive National Assessment?

Code of Federal Regulations, 2011 CFR

2011-10-01

... Assessment? 86.120 Section 86.120 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT... INFRASTRUCTURE GRANT (BIG) PROGRAM Completing the Comprehensive National Assessment § 86.120 What is the Comprehensive National Assessment? The Comprehensive National Assessment is a national report integrating the...

50 CFR 86.120 - What is the Comprehensive National Assessment?

Code of Federal Regulations, 2010 CFR

2010-10-01

... Assessment? 86.120 Section 86.120 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT... INFRASTRUCTURE GRANT (BIG) PROGRAM Completing the Comprehensive National Assessment § 86.120 What is the Comprehensive National Assessment? The Comprehensive National Assessment is a national report integrating the...

Reliability and Validity of Autism Assessments and Diagnosis Using Telemedicine?

DTIC Science & Technology

2009-09-01

intonation 67% 65% - 2 % ADOSa4: immediate echolalia 67% 65% -2 % ADOSa5: stereotyped language 71% 75% 4 % ADOSa6: contact gestures 86% 80% - 6 % ADOSa7...76% 91% 15% ADI35: reciprocal conversation 81% 76% -5% ADI33: stereotyped lang/ echolalia 76% 86% 10% ADI36: inappropriate questions 91% 91% No

Investigation of effect on glycosylated hemoglobin, blood pressure, and body mass index of diabetes intensive education program in patients with type 2 diabetes mellitus.

PubMed

Beyazit, Emel; Mollaoğlu, Mukadder

2011-07-01

This study investigated the effects of a diabetes intensive education program (DIEP) on glycosylated hemoglobin (HbA(1)c), body mass index (BMI), and arterial blood pressure (BP). An 8-week randomized-controlled trial was conducted in Cumhuriyet University Hospital. Diabetes patients were randomized to control group (CG; n = 25) and intervention group (IG; n = 25) who received DIEP, including the factors affecting metabolic control and implementation of diabetes guidelines. Primary outcomes included HbA(1)c, BP, and BMI. After the 8 weeks, there was a significant decrease in HbA(1)c mean values for the intervention group. Also, BP significantly decreased from 143/87 to 130/80 mmHg in the IG as compared with an increase from 137/82 to 137/86 mmHg in the CG. In addition, the results demonstrated that DIEP improved the number of patients at goal for BP (130/80 mmHg). Baseline BMI did not change significantly in either group during the course of the study. These findings show that the DIEP may be effective in decreasing HbA(1)c levels and improving adherence to BP control.

Increased incidence of thyroid dysfunction and autoimmunity in patients with vernal keratoconjunctivitis.

PubMed

Stagi, Stefano; Pucci, Neri; Di Grande, Laura; de Libero, Cinzia; Caputo, Roberto; Pantano, Stefano; Mattei, Ivan; Mori, Francesca; de Martino, Maurizio; Novembre, Elio

2014-01-01

Hormones may play a role in the pathophysiology of vernal keratoconjunctivitis (VKC). An increased incidence of thyroid autoantibodies was recently observed in VKC, although there were no data on thyroid function. Two hundred and eighty-eight patients (202 males, 86 females; range 5.5 to 16.9 years) with VKC were evaluated and compared with 188 normal age- and sex-matched subjects. In all subjects, serum concentrations of free T4, TSH, thyroperoxidase, thyroglobulin, and TSHr autoantibodies were evaluated. In VKC, the family history of thyroid diseases showed no significant differences compared to the controls (9.4 versus 8.6%), whereas the family history of autoimmune diseases was significantly higher (13.2% versus 6.3%; P<0.05). Subclinical hypothyroidism was diagnosed in 6.6% (versus 1.6% of the controls; P<0.05) and overt hypothyroidism in 0.7% (versus 0.0% of the controls; P = NS). Finally, 5.2% of patients were positive for thyroid autoantibodies, which were significantly higher with respect to the controls (0.5%, P<0.05). In the patients positive for thyroid autoantibodies, 80% showed a sonography pattern that suggested autoimmune thyroiditis. Thyroid function and autoimmunity abnormalities are frequently present in children with VKC. Children with VKC should be screened for thyroid function and evaluated for thyroid autoimmunity.

Increased Incidence of Thyroid Dysfunction and Autoimmunity in Patients with Vernal Keratoconjunctivitis

PubMed Central

Stagi, Stefano; Pucci, Neri; Di Grande, Laura; de Libero, Cinzia; Caputo, Roberto; Pantano, Stefano; Mattei, Ivan; Mori, Francesca; de Martino, Maurizio; Novembre, Elio

2014-01-01

Hormones may play a role in the pathophysiology of vernal keratoconjunctivitis (VKC). An increased incidence of thyroid autoantibodies was recently observed in VKC, although there were no data on thyroid function. Two hundred and eighty-eight patients (202 males, 86 females; range 5.5 to 16.9 years) with VKC were evaluated and compared with 188 normal age- and sex-matched subjects. In all subjects, serum concentrations of free T4, TSH, thyroperoxidase, thyroglobulin, and TSHr autoantibodies were evaluated. In VKC, the family history of thyroid diseases showed no significant differences compared to the controls (9.4 versus 8.6%), whereas the family history of autoimmune diseases was significantly higher (13.2% versus 6.3%; P<0.05). Subclinical hypothyroidism was diagnosed in 6.6% (versus 1.6% of the controls; P<0.05) and overt hypothyroidism in 0.7% (versus 0.0% of the controls; P = NS). Finally, 5.2% of patients were positive for thyroid autoantibodies, which were significantly higher with respect to the controls (0.5%, P<0.05). In the patients positive for thyroid autoantibodies, 80% showed a sonography pattern that suggested autoimmune thyroiditis. Thyroid function and autoimmunity abnormalities are frequently present in children with VKC. Children with VKC should be screened for thyroid function and evaluated for thyroid autoimmunity. PMID:25140177

1 CFR 8.6 - Forms of publication.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Forms of publication. 8.6 Section 8.6 General... FEDERAL REGULATIONS § 8.6 Forms of publication. (a) Under section 1506 of title 44, United States Code, the Administrative Committee authorizes publication of the Code of Federal Regulations in the...

1 CFR 8.6 - Forms of publication.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true Forms of publication. 8.6 Section 8.6 General... FEDERAL REGULATIONS § 8.6 Forms of publication. (a) Under section 1506 of title 44, United States Code, the Administrative Committee authorizes publication of the Code of Federal Regulations in the...

50 CFR 86.13 - What is boating infrastructure?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What is boating infrastructure? 86.13 Section 86.13 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... (BIG) PROGRAM General Information About the Grant Program § 86.13 What is boating infrastructure...

[Proliferation and IFN-gamma secretion of autologous T lymphocytes stimulated by myeloid leukemia cells induced with rhGM-CSF and rhIL-4].

PubMed

Xie, Yan-Hui; Chen, Qin-Fen; Xie, Yi; Xie, Hong

2002-12-01

To observe the proliferation of T lymphocytes stimulated by CML and AML cells which were induced by rhGM-CSF and rhIL-4, and the secretion of IFN-gamma from proliferated T lymphocytes, the expression of CD80, CD86 and HLA-DR on CML and AML cells induced by GM-CSF and IL-4 was assayed by flow cytometry in vitro. Then one-way mixed lymphocyte reaction was carried out, with induced leukemia cells as stimulating cells and auto-T lymphocytes as reactive cells. The secretion of IFN-gamma from T lymphocytes was determined by double antibody sandwich ELISA. The results showed that GM-CSF and IL-4 significantly upregulated the expression of CD80, CD86 and HLA-DR on CML cells and CD80 and CD86 on AML cells, which could stimulate the T lymphocyte proliferation and high secretion of IFN-gamma (in CML group) of autologous T lymphocytes. It is concluded that the CML and AML cells induced by GM-CSF and IL-4 have the ability to present tumor specific antigen to auto-T lymphocyte.

Neuropsychological differences between men and women with Alzheimer's disease.

PubMed

Ryan, Joseph J; Glass Umfleet, Laura; Kreiner, David S; Fuller, Amanda M; Paolo, Anthony M

2018-04-01

It has been suggested that men and women with Alzheimer's disease (AD) at comparable levels of global cognitive impairment perform differently on neuropsychological measures. Such differences may have practical implications for designing cognitive interventions that address symptoms of dementia. We compared men (n = 86) and women (n = 96) with AD on tests of immediate and delayed prose memory, verbal fluency, semantic fluency, semantic memory and confrontation naming. Mean years for age, education and duration of illness were 70.81 (SD = 7.55), 13.37 (SD = 3.38) and 2.17 (SD = 1.72) for men and 73.11(SD = 8.53), 12.27 (SD = 2.86) and 2.42 (SD = 1.92) for women. The groups were comparable in global cognitive functioning as indicated by Dementia Rating Scale total scores for men of 89.27 (SD = 29.80) and women of 90.86 (SD = 30.20). Men earned significantly better scores in immediate prose memory, semantic verbal fluency, semantic memory and response naming. Men and women performed similarly on the remaining tests. When the variables of age, education and duration of disease were controlled, the significant effect of gender was maintained only on tests of semantic fluency, semantic memory and confrontation naming. The hypothesis of the study was partially confirmed in that women with AD evidenced greater impairment than men with AD on three of six neuropsychological measures even after potentially confounding variables were controlled.

4D.10: CHANGES IN PWV IN PREVIOUSLY UNTREATED MILD HYPERTENSIVES ARE RELATED TO REDUCTION OF BLOOD PRESSURE BY TREATMENT.

PubMed

Rodilla Sala, E; Millasseau, S; Escrivá, M; García, J; Costa, J A; Pascual, J M

2015-06-01

Changes in target organ lesions, even beyond reduction of blood pressure, have been shown to have predictive value. Destiffening of arterial damage seems to be possible but the mechanisms are still elusive. We report changes in pulse wave velocity (PWV) after one year of treatment in new diagnosed previously untreated, hypertensive patients. We included in this longitudinal study 356 consecutive, never-treated patients with suspected hypertension. After standard clinical assessment, including ambulatory blood pressure monitoring (ABPM), pulse wave analysis and PWV (Sphygmocor®, AtcorMedical), 231 showed elevated office and/or ambulatory blood pressure (BP) and received monotherapy treatment accordingly. 125 patients who showed to be normotensive, served as control group. Clinical assessment was repeated after a median of 1.1 years in the whole cohort. PWV was adjusted to BP. In the whole group, 179 patients were female (50.3%), mean age was 48.8 ± 12years. The hypertensive diagnosed group tended to be older (50 vs. 46 years, p < 0,001) and had higher PWV even after mean BP adjustment (8.6 ± 2.0 vs. 8.0 ± 1.4 m/s, p < 0.001), higher baseline office, ambulatory and central BP (145/86, 136/86 and 138/87 mmHg vs. 125/75, 120/76 and 120/79, respectively, p < 0,001). After 1 year of treatment, BP was significantly improved only in the hypertensive group (follow-up office, ambulatory and central BP 128/75, 124/78, 121/79 mmHg, pintragroup < 0.001) and remained constant in the control group (126/74, 120/76, 120/80, pintragroup = ns). The reduction of central and peripheral systolic BP in the hypertensive group was of the same magnitude (-17 vs -17 mmHg, p = ns). PWV was significantly reduced in both groups even after BP adjustment, at follow-up they were similar between groups (7.8 vs. 7.7, p = ns). The reduction of adjusted PWV was significantly higher in the hypertensive group (Delta = 0.86 vs. 0,20 m/s, p = 0.001). There was no differential effect in PWV reduction depending on antihypertensive class, except for patients treated with nebivolol. Blood pressure reduction in newly diagnosed stage 1 hypertensive patients improves PWV within a year of treatment, confirming that rapid tight control of BP is important even in mild hypertensives. Of note, arterial destiffening seems to go beyond BP reductions.

Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance.

PubMed

Gupta, Sundeep K; Medalla, Felicita; Omondi, Michael W; Whichard, Jean M; Fields, Patricia I; Gerner-Smidt, Peter; Patel, Nehal J; Cooper, Kara L F; Chiller, Tom M; Mintz, Eric D

2008-06-01

The incidence of paratyphoid fever, including paratyphoid fever caused by antimicrobial-resistant strains, is increasing globally. However, the epidemiologic and laboratory characteristics of paratyphoid fever in the United States have never been studied. We attempted to interview all patients who had been infected with laboratory-confirmed Salmonella serotypes Paratyphi A, Paratyphi B, or Paratyphi C in the United States with specimens collected from 1 April 2005 through 31 March 2006. At the Centers for Disease Control and Prevention (CDC), isolates underwent serotype confirmation, antimicrobial susceptibility testing, and pulsed-field gel electrophoresis typing. Of 149 patients infected with Salmonella Paratyphi A, we obtained epidemiologic information for 89 (60%); 55 (62%) of 86 were hospitalized. Eighty-five patients (96%) reported having travel internationally, and 80 (90%) had traveled to South Asia. Of the 146 isolates received at the CDC, 127 (87%) were nalidixic acid resistant; nalidixic acid resistance was associated with travel to South Asia (odds ratio, 17.0; 95% confidence interval, 3.8-75.9). All nalidixic acid-resistant isolates showed decreased susceptibility to ciprofloxacin (minimum inhibitory concentration, > or = 0.12 microg/mL). Of 49 patients infected with Salmonella Paratyphi B, only 12 (24%) were confirmed to have Paratyphi B when tested at the CDC. Four (67%) of 6 patients were hospitalized, and 5 (83%) reported travel (4 to the Andean region of South America). One case of Salmonella Paratyphi C infection was reported in a traveler to West Africa with a urinary tract infection. Physicians should be aware of the increasing incidence of infection due to Salmonella Paratyphi A and treatment options given its widespread antimicrobial resistance. A paratyphoid fever vaccine is urgently needed. Continued surveillance for paratyphoid fever will help guide future prevention and treatment recommendations.

21 CFR 129.80 - Processes and controls.

Code of Federal Regulations, 2010 CFR

2010-04-01

... determine whether any of the coliform organisms are E. coli. (2) For chemical, physical, and radiological... bactericidal action to that required in paragraph (d)(3) of this section. (e) Unit package production code...

21 CFR 129.80 - Processes and controls.

Code of Federal Regulations, 2011 CFR

2011-04-01

... determine whether any of the coliform organisms are E. coli. (2) For chemical, physical, and radiological... bactericidal action to that required in paragraph (d)(3) of this section. (e) Unit package production code...

Involving consumers in assessing service quality: benefits of using a qualitative approach.

PubMed Central

Powell, J; Lovelock, R; Bray, J; Philp, I

1994-01-01

Although important to users, practice standards rarely incorporate users' views of care provided. These views are a valuable source of information, even though there are limits to their value. To improve the standards of care in a 20 bed hospital elderly care unit caring for acute medical conditions a qualitative approach was used. Patients' and carers' perceptions of care and problems with the process of care in the unit were elicited with a specially designed semistructured interview schedule in 83 separate tape recorded interviews with a research nurse in patients' homes. In all, 50 patients and 35 carers were interviewed between 6 June 1991 and 28 May 1992. Of the 50 patients, 33 were female; seven patients were aged less than 80 years, 16, 80-85; 21, 86-90; and six over 90. A total of 16 patients lived with spouses or other carers, two with non-carers, and 32 lived alone, 18 of whom received informal care. Content analysis of the interviews disclosed patients' and carers' general satisfaction with individualised professional care and planning of follow up services on discharge but dissatisfaction in the lack of information about and involvement in treatment and care and about specific staff notes. These findings have prompted remedial changes in clinical practice in the unit; they have also formed the structure of a criterion based survey of practice. The authors conclude that the qualitative approach suited elderly users and also provided the basis for the findings to be incorporated into a continuous audit cycle through a process of feedback and standard setting. PMID:10140234

Research Study of River Information Services on the US Inland Waterway Network

DTIC Science & Technology

2012-03-01

Development Center International Research Office (ERDC-IRO) 86-88 Blenheim Crescent West Ruislip Middlesex , HA4 7HL United Kingdom U.S. Army...International Technology Center – Atlantic (USAITC-A) Fiscal Office POC: Sandra Gordon 86-88 Blenheim Crescent West Ruislip Middlesex , HA4 7HL United

Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus

PubMed Central

Colonna, Lucrezia; Dinnall, Joudy-Ann; Shivers, Debra K; Frisoni, Lorenza; Caricchio, Roberto; Gallucci, Stefania

2006-01-01

We analyzed the activation and function of dendritic cells (DCs) in the spleens of diseased, lupus-prone NZM2410 and NZB-W/F1 mice and age-matched BALB/c and C57BL/6 control mice. Lupus DCs showed an altered ex vivo costimulatory profile, with a significant increase in the expression of CD40, decreased expression of CD80 and CD54, and normal expression of CD86. DCs from young lupus-prone NZM2410 mice, before the development of the disease, expressed normal levels of CD80 and CD86 but already overexpressed CD40. The increase in CD40-positive cells was specific for DCs and involved the subset of myeloid and CD8α+ DCs before disease onset, with a small involvement of plasmacytoid DCs in diseased mice. In vitro data from bone marrow-derived DCs and splenic myeloid DCs suggest that the overexpression of CD40 is not due to a primary alteration of CD40 regulation in DCs but rather to an extrinsic stimulus. Our analyses suggest that the defect of CD80 in NZM2410 and NZB-W/F1 mice, which closely resembles the costimulatory defect found in DCs from humans with systemic lupus erythematosus, is linked to the autoimmune disease. The increase in CD40 may instead participate in disease pathogenesis, being present months before any sign of autoimmunity, and its downregulation should be explored as an alternative to treatment with anti-CD40 ligand in lupus. PMID:16507174

50 CFR 86.133 - What are the plan standards?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What are the plan standards? 86.133 Section 86.133 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR...) PROGRAM How States Will Complete the State Program Plans § 86.133 What are the plan standards? You must...

50 CFR 86.133 - What are the plan standards?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What are the plan standards? 86.133 Section 86.133 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... (BIG) PROGRAM How States Will Complete the State Program Plans § 86.133 What are the plan standards...

50 CFR 86.53 - What are funding tiers?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What are funding tiers? 86.53 Section 86.53 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... (BIG) PROGRAM How States Apply for Grants § 86.53 What are funding tiers? (a) This grant program will...

Mycobacterium tuberculosis and Rifampin Resistance, United Kingdom

PubMed Central

Sam, I-Ching; More, Philip; Kemp, Melanie; Brown, Timothy

2006-01-01

The United Kingdom Health Protection Agency Mycobacterium Reference Unit offers a national "Fastrack" molecular service for detecting Mycobacterium tuberculosis complex (MTBC) and rifampin resistance by using the INNO-LiPA Rif.TB assay. We analyzed the service in a routine, nontrial context of 1,997 primary clinical specimens, including 658 nonrespiratory specimens. The overall adjusted concordance, sensitivity, specificity, positive predictive value, and negative predictive value for detecting MTBC were 91.2%, 85.2%, 96.2%, 95.7%, and 86.7%, respectively (unadjusted, 86.7%, 85.2%, 88.2%, 86.9%, and 86.7%), when false-positive samples from patients (n = 83) with a known microbiologic diagnosis of MTBC or patients receiving current or recent antituberculous treatment were excluded. The parameters for detecting rifampin resistance were 99.1%, 95.0%, 99.6%, 92.7%, and 99.7%, respectively. The assay enabled earlier diagnosis of MTBC and rifampin resistance (15.2 days) compared with culture-based techniques (30.7 days). PMID:16704831

Effect of a mobile health, sensor-driven asthma management platform on asthma control.

PubMed

Barrett, Meredith A; Humblet, Olivier; Marcus, Justine E; Henderson, Kelly; Smith, Ted; Eid, Nemr; Sublett, J Wesley; Renda, Andrew; Nesbitt, LaQuandra; Van Sickle, David; Stempel, David; Sublett, James L

2017-11-01

Asthma inflicts a significant health and economic burden in the United States. Self-management approaches to monitoring and treatment can be burdensome for patients. To assess the effect of a digital health management program on asthma outcomes. Residents of Louisville, Kentucky, with asthma were enrolled in a single-arm pilot study. Participants received electronic inhaler sensors that tracked the time, frequency, and location of short-acting β-agonist (SABA) use. After a 30-day baseline period during which reference medication use was recorded by the sensors, participants received access to a digital health intervention designed to enhance self-management. Changes in outcomes, including mean daily SABA use, symptom-free days, and asthma control status, were compared among the initial 30-day baseline period and all subsequent months of the intervention using mixed-model logistic regressions and χ 2 tests. The mean number of SABA events per participant per day was 0.44 during the control period and 0.27 after the first month of the intervention, a 39% reduction. The percentage of symptom-free days was 77% during the baseline period and 86% after the first month, a 12% improvement. Improvement was observed throughout the study; each intervention month demonstrated significantly lower SABA use and higher symptom-free days than the baseline month (P < .001). Sixty-nine percent had well-controlled asthma during the baseline period, 67% during the first month of the intervention. Each intervention month demonstrated significantly higher percentages than the baseline month (P < .001), except for month 1 (P = .80). A digital health asthma management intervention demonstrated significant reductions in SABA use, increased number of symptom-free days, and improvements in asthma control. ClinicalTrials.gov Identifier: NCT02162576. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC.

PubMed

Lenherr, Sara M; Clemens, J Quentin; Braffett, Barbara H; Cleary, Patricia A; Dunn, Rodney L; Hotaling, James M; Jacobson, Alan M; Kim, Catherine; Herman, William; Brown, Jeanette S; Wessells, Hunter; Sarma, Aruna V

2016-10-01

We examined the relationship between glycemic control and urinary tract infections in women with type 1 diabetes mellitus. Women enrolled in the Epidemiology of Diabetes Interventions and Complications study, the observational followup of the Diabetes Control and Complications Trial, were surveyed to assess the rate of physician diagnosed urinary tract infections in the preceding 12 months. The relationship between glycated hemoglobin levels and number of urinary tract infections in the previous 12 months was assessed using a multivariable Poisson regression model. A total of 572 women were evaluated at year 17. Mean age was 50.7 ± 7.2 years, mean body mass index was 28.6 ± 5.9 kg/m(2), mean type 1 diabetes duration was 29.8 ± 5.0 years and mean glycated hemoglobin was 8.0% ± 0.9%. Of these women 86 (15.0%) reported at least 1 physician diagnosed urinary tract infection during the last 12 months. Higher glycated hemoglobin levels were significantly associated with number of urinary tract infections such that for every unit increase (1%) in recent glycated hemoglobin level, there was a 21% (p=0.02) increase in urinary tract infection frequency in the previous 12 months after adjusting for race, hysterectomy status, urinary incontinence, sexual activity in the last 12 months, peripheral and autonomic neuropathy, and nephropathy. The frequency of urinary tract infections increases with poor glycemic control in women with type 1 diabetes. This relationship is independent of other well described predictors of urinary tract infections and suggests that factors directly related to glycemic control may influence the risk of lower urinary tract infections. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Modular control of varied locomotor tasks in children with incomplete spinal cord injuries

PubMed Central

Tester, Nicole J.; Kautz, Steven A.; Howland, Dena R.; Clark, David J.; Garvan, Cyndi; Behrman, Andrea L.

2013-01-01

A module is a functional unit of the nervous system that specifies functionally relevant patterns of muscle activation. In adults, four to five modules account for muscle activation during walking. Neurological injury alters modular control and is associated with walking impairments. The effect of neurological injury on modular control in children is unknown and may differ from adults due to their immature and developing nervous systems. We examined modular control of locomotor tasks in children with incomplete spinal cord injuries (ISCIs) and control children. Five controls (8.6 ± 2.7 yr of age) and five children with ISCIs (8.6 ± 3.7 yr of age performed treadmill walking, overground walking, pedaling, supine lower extremity flexion/extension, stair climbing, and crawling. Electromyograms (EMGs) were recorded in bilateral leg muscles. Nonnegative matrix factorization was applied, and the minimum number of modules required to achieve 90% of the “variance accounted for” (VAF) was calculated. On average, 3.5 modules explained muscle activation in the controls, whereas 2.4 modules were required in the children with ISCIs. To determine if control is similar across tasks, the module weightings identified from treadmill walking were used to reconstruct the EMGs from each of the other tasks. This resulted in VAF values exceeding 86% for each child and each locomotor task. Our results suggest that 1) modularity is constrained in children with ISCIs and 2) for each child, similar neural control mechanisms are used across locomotor tasks. These findings suggest that interventions that activate the neuromuscular system to enhance walking also may influence the control of other locomotor tasks. PMID:23761702

The combined use of 87Sr/86Sr and carbon and water isotopes to study the hydrochemical interaction between groundwater and lakewater in mantled karst

USGS Publications Warehouse

Katz, B.G.; Bullen, T.D.

1996-01-01

The hydrochemical interaction between groundwater and lakewater influences the composition of water that percolates downward from the surficial aquifer system through the underlying intermediate confining unit and recharges the Upper Floridan aquifer along highlands in Florida. The 87Sr/86Sr ratio along with the stable isotopes, D, 18O, and 13C were used as tracers to study the interaction between groundwater, lakewater, and aquifer minerals near Lake Barco, a seepage lake in the mantled karst terrane of northern Florida. Upgradient from the lake, the 87Sr/86Sr ratio of groundwater decreases with depth (mean values of 0.71004, 0.70890, and 0.70852 for water from the surficial aquifer system, intermediate confining unit, and Upper Floridan aquifer, respectively), resulting from the interaction of dilute oxygenated recharge water with aquifer minerals that are less radiogenic with depth. The concentrations of Sr2+ generally increase with depth, and higher concentrations of Sr2+ in water from the Upper Floridan aquifer (20-35 ??g/L), relative to water from the surficial aquifer system and the intermediate confining unit, result from the dissolution of Sr-bearing calcite and dolomite in the Eocene limestone. Dissolution of calcite [??13C = -1.6 permil (???)] is also indicated by an enriched ??13CDIC (-8.8 to - 11.4???) in water from the Upper Floridan aquifer, relative to the overlying hydrogeologic units (??13CDIC < - 16???). Groundwater downgradient from Lake Barco was enriched in 18O and D relative to groundwater upgradient from the lake, indicating mixing of lakewater leakage and groundwater. Downgradient from the lake, the 87Sr/86Sr ratio of groundwater and aquifer material become less radiogenic and the Sr2+ concentrations generally increase with depth. However, Sr2+ concentrations are substantially less than in upgradient groundwaters at similar depths. The lower Sr2+ concentrations result from the influence of anoxic lakewater leakage on the mobility of Sr2+ from clays. Based on results from mass-balance modeling, it is probable that cation exchange plays the dominant role in controlling the 87Sr/86Sr ratio of groundwater, both upgradient and downgradient from Lake Barco. Even though groundwater from the three distinct hydrogeologic units displays considerable variability in Sr concentration and isotopic composition, the dominant processes associated with the mixing of lakewater leakage with groundwater, as well as the effects of mineral-water interaction, can be ascertained by integrating the use of stable and radiogenic isotopic measurements of groundwater, lakewater, and aquifer minerals.

Simultaneous integrated boost to intraprostatic lesions using different energy levels of intensity-modulated radiotherapy and volumetric-arc therapy

PubMed Central

Sonmez, S; Erbay, G; Guler, O C; Arslan, G

2014-01-01

Objective: This study compared the dosimetry of volumetric-arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) with a dynamic multileaf collimator using the Monte Carlo algorithm in the treatment of prostate cancer with and without simultaneous integrated boost (SIB) at different energy levels. Methods: The data of 15 biopsy-proven prostate cancer patients were evaluated. The prescribed dose was 78 Gy to the planning target volume (PTV78) including the prostate and seminal vesicles and 86 Gy (PTV86) in 39 fractions to the intraprostatic lesion, which was delineated by MRI or MR-spectroscopy. Results: PTV dose homogeneity was better for IMRT than VMAT at all energy levels for both PTV78 and PTV86. Lower rectum doses (V30–V50) were significantly higher with SIB compared with PTV78 plans in both IMRT and VMAT plans at all energy levels. The bladder doses at high dose level (V60–V80) were significantly higher in IMRT plans with SIB at all energy levels compared with PTV78 plans, but no significant difference was observed in VMAT plans. VMAT plans resulted in a significant decrease in the mean monitor units (MUs) for 6, 10, and 15 MV energy levels both in plans with and those without SIB. Conclusion: Dose escalation to intraprostatic lesions with 86 Gy is safe without causing serious increase in organs at risk (OARs) doses. VMAT is advantageous in sparing OARs and requiring less MU than IMRT. Advances in knowledge: VMAT with SIB to intraprostatic lesion is a feasible method in treating prostate cancer. Additionally, no dosimetric advantage of higher energy is observed. PMID:24319009

50 CFR 86.11 - What does the national BIG Program do?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What does the national BIG Program do? 86.11 Section 86.11 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM General Information About the Grant Program § 86.11 What does the national BIG...

50 CFR 86.72 - Do any other Federal requirements apply to this program?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Do any other Federal requirements apply to this program? 86.72 Section 86.72 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... INFRASTRUCTURE GRANT (BIG) PROGRAM How States Manage Grants § 86.72 Do any other Federal requirements apply to...

50 CFR 86.116 - May I change the questions in the survey?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false May I change the questions in the survey? 86.116 Section 86.116 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF... INFRASTRUCTURE GRANT (BIG) PROGRAM How States Will Complete Access Needs Surveys § 86.116 May I change the...

50 CFR 86.130 - What does the State program plan do?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What does the State program plan do? 86.130 Section 86.130 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM How States Will Complete the State Program Plans § 86.130 What does the State...

50 CFR 86.40 - How much money is available for grants?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false How much money is available for grants? 86.40 Section 86.40 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM Funding Availability § 86.40 How much money is available for grants? There is $32...

50 CFR 86.41 - How long will the money be available?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false How long will the money be available? 86.41 Section 86.41 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... INFRASTRUCTURE GRANT (BIG) PROGRAM Funding Availability § 86.41 How long will the money be available? Under the...

50 CFR 86.41 - How long will the money be available?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false How long will the money be available? 86.41 Section 86.41 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM Funding Availability § 86.41 How long will the money be available? Under the Act...

50 CFR 86.41 - How long will the money be available?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false How long will the money be available? 86.41 Section 86.41 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... INFRASTRUCTURE GRANT (BIG) PROGRAM Funding Availability § 86.41 How long will the money be available? Under the...

50 CFR 86.40 - How much money is available for grants?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false How much money is available for grants? 86.40 Section 86.40 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM Funding Availability § 86.40 How much money is available for grants? There is $32...

50 CFR 86.40 - How much money is available for grants?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false How much money is available for grants? 86.40 Section 86.40 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... INFRASTRUCTURE GRANT (BIG) PROGRAM Funding Availability § 86.40 How much money is available for grants? There is...

50 CFR 86.41 - How long will the money be available?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false How long will the money be available? 86.41 Section 86.41 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM Funding Availability § 86.41 How long will the money be available? Under the Act...

50 CFR 86.40 - How much money is available for grants?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false How much money is available for grants? 86.40 Section 86.40 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... INFRASTRUCTURE GRANT (BIG) PROGRAM Funding Availability § 86.40 How much money is available for grants? There is...

50 CFR 86.40 - How much money is available for grants?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false How much money is available for grants? 86.40 Section 86.40 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM Funding Availability § 86.40 How much money is available for grants? There is $32...

50 CFR 86.112 - What are the advantages of doing a survey?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the advantages of doing a survey? 86.112 Section 86.112 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF... INFRASTRUCTURE GRANT (BIG) PROGRAM How States Will Complete Access Needs Surveys § 86.112 What are the advantages...

46. BUILDING NO. 519, ETHER AND ALCOHOL RECOVERY HOUSE, INTERIOR, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. BUILDING NO. 519, ETHER AND ALCOHOL RECOVERY HOUSE, INTERIOR, CONTROL PANEL LEVEL (2ND DECK) OF ETHER AND ALCOHOL STILL BUILDING, LOOKING NORTH, SHOWING TWO ALCOHOL DISTILLATION TOWERS BEHIND 'MIXED SOLVENT UNIT' CONTROL PANEL. - Picatinny Arsenal, 500 Area, Powder Factory & Power House, State Route 15 near I-80, Dover, Morris County, NJ

Optimal Target Range of Closed-Loop Inspired Oxygen Support in Preterm Infants: A Randomized Cross-Over Study.

PubMed

van den Heuvel, Maria Elisabeth Nicoletta; van Zanten, Henriette A; Bachman, Tom E; Te Pas, Arjan B; van Kaam, Anton H; Onland, Wes

2018-06-01

To investigate the effect of different pulse oximetry (SpO 2 ) target range settings during automated fraction of inspired oxygen control (A-FiO 2 ) on time spent within a clinically set SpO 2 alarm range in oxygen-dependent infants on noninvasive respiratory support. Forty-one preterm infants (gestational age [median] 26 weeks, age [median] 21 days) on FiO 2  >0.21 receiving noninvasive respiratory support were subjected to A-FiO 2 using 3 SpO 2 target ranges (86%-94%, 88%-92%, or 89%-91%) in random order for 24 hours each. Before switching to the next target range, SpO 2 was manually controlled for 24 hours (washout period). The primary outcome was the time spent within the clinically set alarm limits of 86%-94%. The percent time within the 86%-94% SpO 2 alarm range was similar for all 3 A-FiO 2 target ranges (74%). Time spent in hyperoxemia was not significantly different between target ranges. However, the time spent in severe hypoxemia (SpO 2  <80%) was significantly reduced during the narrowed target ranges of A-FiO 2 (88%-92%; 1.9%, 89%-91%; 1.7%) compared with the wide target range (86%-94%; 3.4%, P < .001). There were no differences between the 88%-92% and 89-91% target range. Narrowing the target range of A-FiO 2 to the desired median ±2% is effective in reducing the time spent in hypoxemia, without increasing the risk of hyperoxemia. www.trialregister.nl: NTR4368. Copyright © 2018 Elsevier Inc. All rights reserved.

50 CFR 86.117 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false [Reserved] 86.117 Section 86.117 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM How...

50 CFR 86.135 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false [Reserved] 86.135 Section 86.135 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM How...

Subclinical hypothyroidism is associated with migraine: A case-control study.

PubMed

Rubino, Elisa; Rainero, Innocenzo; Garino, Francesca; Vicentini, Costanza; Govone, Flora; Vacca, Alessandro; Gai, Annalisa; Gentile, Salvatore; Govone, Guido; Ragazzoni, Federico; Pinessi, Lorenzo; Giordana, Maria Teresa; Limone, Paolo

2018-01-01

Background Recent studies suggested a potential association between both overt and subclinical hypothyroidism and migraine. Aims of this study were to estimate the comorbidity of migraine in patients with subclinical hypothyroidism and to evaluate associated clinical characteristics. Methods Using a case-control strategy, 151 consecutive subclinical hypothyroidism patients (mean age 48.36 ± 15.86 years) and 150 controls (mean age 50.86 ± 9.19 years) were recruited. In all subjects, migraine characteristics were collected through a direct interview. Clinical and biochemical parameters (thyroid-stimulating hormone, free triiodothyronine, free thyroxine, and anti-thyroid antibodies) were compared between subclinical hypothyroidism patients in comorbidity with migraine and subclinical hypothyroidism patients without migraine. Results The prevalence of lifetime migraine was significantly higher in subclinical hypothyroidism patients in comparison with controls (46% vs. 13%, p < 0.001; OR 5.80; 95% CI = 3.35-10.34). Both migraine without and with aura were significantly higher in subclinical hypothyroidism patients than controls ( p < 0.001 and p = 0.010, respectively). Thyroid hormones and concentrations of antibodies did not differ between subclinical hypothyroidism patients with and without migraine. Interestingly, a comorbidity for autoimmune diseases was observed in subclinical hypothyroidism patients with migraine in respect to those without migraine ( p = 0.005). Conclusions Our data suggest that migraine is more frequent in patients with subclinical hypothyroidism in respect to controls. Further studies are needed in order to confirm this association.

Assessing the growth and recovery of Salmonella Enteritidis SE86 after sodium dichloroisocyanurate exposure

PubMed Central

Ferreira, Fernanda Stoduto; Horvath, Mariana Bandeira; Tondo, Eduardo Cesar

2013-01-01

The objective of the present study was to assess the growth and the recovery of Salmonella (S.) Enteritidis SE86 in different diluents, culture media and using different plating methods after the exposure to 200 mg/kg sodium dichloroisocyanurate (NaDCC). Before and after NaDCC exposure, SE86 was cultured at 30 °C and 7 °C in the following diluents: Peptone water (P), Saline solution (SaS), Peptone water+Saline solution (P+SaS), Peptone water+Tween 80+Lecithin+Sodium thiosulfate (P+N) and Saline solution+Tween 80+Lecithin+Sodium thiosulfate (SaS+N). The SaS diluent was chosen because it was able to maintain cells viable without growth and was further used for plating SE86 on non selective medium (Tryptic Soy Agar-TSA) and on selective media (Mannitol Lysine Crystal Violet Brilliant Green Agar-MLCB; Brilliant Green Agar-BGA; Salmonella Shigella Agar-SS and Xylose Lysine Dextrose–XLD). The Thin Agar Layer method (TAL) i.e., selective media overlayed with non selective TSA was also evaluated. Results indicated that SE86 not exposed to NaDCC was able to grow in P, P+N, SaS+N and P+SaS, but not in SaS, that was able to maintain cells viable. SE86 exposed to NaDCC demonstrated similar counts after dilution in SaS and the plating on non selective TSA, selective media MLCB, BGA, SS and XLD and on TAL media. SE86, S. Typhimurium and S. Bredeney, exposed or not exposed to NaDCC, showed no significant differences in counts on TSA, XLD and XLD overlayed with TSA, suggesting that all those media may be used to quantify NaDCC-exposed Salmonella by plating method. PMID:24516446

An acoustic filter based on layered structure

PubMed Central

Steer, Michael B.

2015-01-01

Acoustic filters (AFs) are key components to control wave propagation in multi-frequency systems. We present a design which selectively achieves acoustic filtering with a stop band and passive amplification at the high- and low-frequencies, respectively. Measurement results from the prototypes closely match the design predictions. The AF suppresses the high frequency aliasing echo by 14.5 dB and amplifies the low frequency transmission by 8.0 dB, increasing an axial resolution from 416 to 86 μm in imaging. The AF design approach is proved to be effective in multi-frequency systems. PMID:25829548

Self-Esteem and Academic Achievement: A Comparative Study of Adolescent Students in England and the United States

ERIC Educational Resources Information Center

Booth, Margaret Zoller; Gerard, Jean M.

2011-01-01

Utilizing mixed methodology, this paper investigates the relationship between self-esteem and academic achievement for young adolescents within two Western cultural contexts: the United States and England. Quantitative and qualitative data from 86 North American and 86 British adolescents were utilized to examine the links between self-esteem and…

50 CFR 86.62 - What must I do after my project has been selected?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What must I do after my project has been selected? 86.62 Section 86.62 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF... INFRASTRUCTURE GRANT (BIG) PROGRAM How the Service Selects Projects To Receive Grants § 86.62 What must I do...

50 CFR 86.134 - What if I am already carrying out a plan?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What if I am already carrying out a plan? 86.134 Section 86.134 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF... INFRASTRUCTURE GRANT (BIG) PROGRAM How States Will Complete the State Program Plans § 86.134 What if I am already...

50 CFR 86.63 - May I appeal if my project is not selected?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false May I appeal if my project is not selected? 86.63 Section 86.63 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM How the Service Selects Projects To Receive Grants § 86.63 May I appeal if my...

50 CFR 86.113 - What if I have recently completed a boat access survey?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What if I have recently completed a boat access survey? 86.113 Section 86.113 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... completed a boat access survey? If the recent survey substantially answers the provisions in § 86.118, the...

50 CFR 86.113 - What if I have recently completed a boat access survey?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false What if I have recently completed a boat access survey? 86.113 Section 86.113 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... completed a boat access survey? If the recent survey substantially answers the provisions in § 86.118, the...

50 CFR 86.113 - What if I have recently completed a boat access survey?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What if I have recently completed a boat access survey? 86.113 Section 86.113 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... completed a boat access survey? If the recent survey substantially answers the provisions in § 86.118, the...

The effect of coronary artery plaque composition, morphology and burden on Absorb bioresorbable vascular scaffold expansion and eccentricity - A detailed analysis with optical coherence tomography.

PubMed

Shaw, Elizabeth; Allahwala, Usaid K; Cockburn, James A; Hansen, Thomas C E; Mazhar, Jawad; Figtree, Gemma A; Hansen, Peter S; Bhindi, Ravinay

2015-04-01

Suboptimal stent expansion correlates with adverse cardiac events. There is limited information regarding Absorb bioresorbable vascular scaffold (BVS) expansion characteristics. Optical coherence tomography (OCT) allows for high-resolution assessment of plaque morphology, composition and assessment of BVS expansion. This study evaluates coronary plaque composition, morphology and burden and their effect on Absorb BVS expansion using OCT. Two thousand three hundred and thirty four frames totalling 462.6 mm of BVS from twenty OCT-guided BVS implantations were examined. 200 μm longitudinal cross-sections of each BVS were analysed for lumen contours and plaque characteristics. The relationship between each plaque characteristic and scaffold expansion index (SEI) or scaffold eccentricity index (SEC) was analysed by repeated measures ANOVA. Forty-four fibrous and 265 calcific plaques were identified. Lower SEI was significantly (p<0.001) associated with greater calcific plaque (CP) area (mean SEI 78.9% vs. 80.0%), thickness (78.5% vs. 80.4%) and lower CP depth (78.3% vs. 80.2%). Lower SEC was significantly (p<0.001) associated with greater fibrous plaque (FP) area (0.84 vs. 0.85), thickness (0.83 vs. 0.86), arc angle (0.84 vs. 0.85), greater CP area (0.83 vs. 0.86), CP thickness (0.83 vs. 0.86), CP angle (0.84 vs. 0.85) and lower CP depth (0.84 vs. 0.85). Greater FP area was associated with greater SEI (81.0% vs. 80.0%, p<0.001), even after adjustment for target vessel size. Greater FP angle (80.7% vs 78.3%, p<0.001) and quadrants occupied were also associated (80.0% vs 78.5%, p<0.002) with greater SEI. BVS expansion and eccentricity are significantly impacted by plaque composition, morphology and burden. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Investigating Vertical Mixing Between Two Carbonate Aquifers Using a Multiport Well, Central Texas

NASA Astrophysics Data System (ADS)

Kromann, J.; Wong, C. I.; Hunt, B.; Smith, B.; Banner, J. L.

2011-12-01

Determining the occurrence and extent of mixing between vertically-adjacent aquifers is critical to dual-aquifer management. This can be challenging due to variable well depths and uncertainty as to hydrostratigraphic sources of groundwater. This study uses a multiport monitor well to investigate the degree of aquifer mixing between the overlying Edwards aquifer and underlying Trinity aquifer in central Texas. The results will inform dual-aquifer management as the Trinity aquifer is being developed as an alternative water source to the Edwards aquifer due to pumping limits and projections of increasing water demand. Water levels from isolated hydrostratigraphic units (n = 19) were measured monthly in the well as climate conditions transitioned from wet to dry (Sept 2010 to May 2011). Groundwater was sampled over a two-week interval in May to June 2011. At the start of the monitoring interval, water levels were high in the Edwards and the uppermost units of the Trinity relative to the rest of the Trinity units. Water levels decreased to lower elevations, from about 635 to 585 ft-msl, under dry conditions. Water levels in the lowermost Trinity declined less, from about 630 to 620 ft-msl, under dry conditions. Two zones separating the Edwards and lowermost Trinity showed almost no head change during this period. The water-level variations between the two aquifers suggest that: i) vertical flow potential from the Edwards to the Trinity occurs during dry conditions, ii) the uppermost stratigraphic units of the Trinity and Edwards are mixing, and iii) portions of the Trinity behave as an aquitard, providing hydrologic separation between the Edwards and lowermost Trinity units. Groundwater samples indicate the presence of three distinct hydrochemical facies: Ca-HCO3 (Edwards), Ca-HCO3-SO4 (lowermost Trinity), and Ca-SO4 (Trinity-Glen Rose Fm), suggesting little vertical flow and mixing. Covariation between groundwater 87Sr/86Sr values and SO4 concentrations from units of the Edwards and lowermost Trinity units can be accounted for by a two-end-member fluid mixing model, which uses a unit from the Edwards and lowermost Trinity as end members. This may indicate that 87Sr/86Sr values and SO4 concentrations are controlled by varying extents of mixing between the two units. Groundwater from units in the Glen Rose Formation (between the Edwards and lowermost Trinity units) cannot be accounted for by this mixing process due to elevated SO4 concentrations likely associated with dissolution of evaporites. 87Sr/86Sr values of evaporites recovered from the well are consistent with 87Sr/86Sr values of groundwater from these Glen Rose units. Although the geochemical model results suggest possible mixing between the Edwards and Trinity aquifers, water-level variations and the presence of distinct hydrochemical facies indicate that vertical flow between the Edwards and Trinity is limited to the uppermost units of the Trinity. This study suggests that the Edwards aquifer and lowermost Trinity units are not likely in hydrologic communication and independent management may be possible.

Improvements in cross-infection control in general dental practice.

PubMed

Bentley, E M; Sarll, D W

1995-07-08

A questionnaire about cross-infection control was sent to all GDPs in five FHSAs in the North Western Region. Replies came from 312 dentists, a response rate of 74%. They worked in 185 practices, a response rate of 85%. Gloves were worn routinely by 86% of dentists and 80% of DSAs. Handpieces were autoclaved between patients in 77% of practices. Much however, remains to be improved. DSAs could be better protected if more ultrasonic cleaners were used, eye protection encouraged and heavy duty gloves were available for cleaning instruments. BDA guidelines were reported as being the most influential factor, though it would appear that the media did persuade many practitioners to use autoclavable handpieces and sterilise them after each use.

40 CFR 86.000-9 - Emission standards for 2000 and later model year light-duty trucks.

Code of Federal Regulations, 2013 CFR

2013-07-01

....000-9 Emission standards for 2000 and later model year light-duty trucks. Section 86.000-9 includes...) and CO Model year Percentage 2002 40 2003 80 2004 100 Table A00-6—Useful Life Standards (G/MI) for... applicable model year's heavy light-duty trucks shall not exceed the applicable SFTP standards in table A00-6...

40 CFR 86.000-9 - Emission standards for 2000 and later model year light-duty trucks.

Code of Federal Regulations, 2012 CFR

2012-07-01

....000-9 Emission standards for 2000 and later model year light-duty trucks. Section 86.000-9 includes...) and CO Model year Percentage 2002 40 2003 80 2004 100 Table A00-6—Useful Life Standards (G/MI) for... applicable model year's heavy light-duty trucks shall not exceed the applicable SFTP standards in table A00-6...

40 CFR 86.000-8 - Emission standards for 2000 and later model year light-duty vehicles.

Code of Federal Regulations, 2012 CFR

2012-07-01

....000-8 Emission standards for 2000 and later model year light-duty vehicles. Section 86.000-8 includes... later model year light-duty vehicles shall meet the additional SFTP standards of table A00-2 (defined by...=NOX) and CO Model year Percentage 2000 40 2001 80 2002 100 Table A00-2—Useful Life Standards (G/MI...

40 CFR 86.000-8 - Emission standards for 2000 and later model year light-duty vehicles.

Code of Federal Regulations, 2013 CFR

2013-07-01

....000-8 Emission standards for 2000 and later model year light-duty vehicles. Section 86.000-8 includes... later model year light-duty vehicles shall meet the additional SFTP standards of table A00-2 (defined by...=NOX) and CO Model year Percentage 2000 40 2001 80 2002 100 Table A00-2—Useful Life Standards (G/MI...

47 CFR 80.57 - Canada/U.S.A. channeling arrangement for VHF maritime public correspondence.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Island within the Canada/U.S.A. Coordination Zone. (5) Inland Waters Primary Channel. A channel intended... (Canada) 26 24 Juan de Fuca East (Canada) 86 84 Gulf Islands 27 1 Strait of Georgia South 26 86 Howe Sound 24 84 Strait of Georgia North 26 87 Campbell River 28 85 Washington (Coastal Waters): Cape Johnson 26...

47 CFR 80.57 - Canada/U.S.A. channeling arrangement for VHF maritime public correspondence.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Island within the Canada/U.S.A. Coordination Zone. (5) Inland Waters Primary Channel. A channel intended... (Canada) 26 24 Juan de Fuca East (Canada) 86 84 Gulf Islands 27 1 Strait of Georgia South 26 86 Howe Sound 24 84 Strait of Georgia North 26 87 Campbell River 28 85 Washington (Coastal Waters): Cape Johnson 26...

47 CFR 80.57 - Canada/U.S.A. channeling arrangement for VHF maritime public correspondence.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Island within the Canada/U.S.A. Coordination Zone. (5) Inland Waters Primary Channel. A channel intended... (Canada) 26 24 Juan de Fuca East (Canada) 86 84 Gulf Islands 27 1 Strait of Georgia South 26 86 Howe Sound 24 84 Strait of Georgia North 26 87 Campbell River 28 85 Washington (Coastal Waters): Cape Johnson 26...

47 CFR 80.57 - Canada/U.S.A. channeling arrangement for VHF maritime public correspondence.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Island within the Canada/U.S.A. Coordination Zone. (5) Inland Waters Primary Channel. A channel intended... (Canada) 26 24 Juan de Fuca East (Canada) 86 84 Gulf Islands 27 1 Strait of Georgia South 26 86 Howe Sound 24 84 Strait of Georgia North 26 87 Campbell River 28 85 Washington (Coastal Waters): Cape Johnson 26...

47 CFR 80.57 - Canada/U.S.A. channeling arrangement for VHF maritime public correspondence.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Island within the Canada/U.S.A. Coordination Zone. (5) Inland Waters Primary Channel. A channel intended... (Canada) 26 24 Juan de Fuca East (Canada) 86 84 Gulf Islands 27 1 Strait of Georgia South 26 86 Howe Sound 24 84 Strait of Georgia North 26 87 Campbell River 28 85 Washington (Coastal Waters): Cape Johnson 26...

40 CFR 80.1349 - Alternative sampling and testing requirements for importers who import gasoline into the United...

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements for importers who import gasoline into the United States by truck. 80.1349 Section 80.1349... FUELS AND FUEL ADDITIVES Gasoline Benzene Sampling, Testing and Retention Requirements § 80.1349 Alternative sampling and testing requirements for importers who import gasoline into the United States by...

In vitro Catecholamine Exposure Produces Variable Effects on the B7 Costimulatory Pathway in Human Monocytic Cells

NASA Technical Reports Server (NTRS)

Salicru, A. N.; Crucian, B.; Sams, Clarence; Actor, J. K.; Marshall, G. D., Jr.

2006-01-01

Catecholamines have been associated with immunomodulation of the adaptive immune system towards a Th2 response in vitro. We therefore examined the role of in vitro epinephrine (EPI) and norepinephrine (NE) exposure on the B7 costimulatory expression of antigen presenting cells (APC) from human monocytic cell lines and human peripheral blood mononuclear cells (PBMC). THP1 monocytic cells and CD14+ cells from normal human PBMC were stimulated with lipopolysaccharide (LPS) and incubated with physiologic stress levels (10(exp -6) - 10(exp -8)M) of EPI or NE for 24 hours. Cells were subsequently stained with CD80 FITC, CD86 PE, and CD14 PC5 antibodies and analyzed by flow cytometry for changes in fluorescence and mean fluorescence intensity (MFI). Exposure of THP1 to EPI in vitro at concentrations of 10(exp -6), 10(exp -7) and 10(exp -8)M significantly decreased mean CD80 from 42 plus or minus 0.7% to 11 plus or minus 0.44%, 19.1 plus or minus 2.0%, and 30.7 plus or minus 2.1% expression, respectively (p less than 0.01). In addition, CD86 expression increased with EPI at 10(exp -6), 10(exp -7) and 10(exp -8) M from 9.2 plus or minus 0.52% to 41 plus or minus 3.8%, 26.4 plus or minus 1.9%, and 15.74 plus or minus 1.8% expression, respectively (p less than 0.01). Similar results for mean CD80 and CD86 percent expression were observed for CD14+ cells from PBMC with a sample size of N = 6 and for NE when substituted for EPI. The data show that in vitro exposure to catecholamines significantly decreases %CD86 expression and significantly increases %CD86 expression in THP1 cells and human CD14+ APC. Previous studies have suggested an association between increased CD86 expression and TH2 activity. Thus, these data suggest that immunomodulation by catecholamines results in part by the variable effects of the B7 costimulatory pathway in APC.

Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis

PubMed Central

Mohabbati Mobarez, Ashraf; Bagheri Amiri, Fahimeh; Esmaeili, Saber

2017-01-01

Background Q fever is a main zoonotic disease around the world. The aim of this meta-analysis was to estimate the overall seroprevalence of Coxiella burnetii among human and animal population in Iran. Methods Major national and international databases were searched from 2005 up to August 2016. We extracted the prevalence of Q fever antibodies (IgG) as the main primary outcome. We reported the prevalence of the seropositivity as point and 95% confidence intervals. Results The overall seroprevalence of IgG phase I and II antibodies of Q fever in human was 19.80% (95% CI: 16.35–23.25%) and 32.86% (95% CI: 23.80–41.92%), respectively. The herd and individual prevalence of C. burnetii antibody in goat were 93.42% (95% CI: 80.23–100.00) and 31.97% (95% CI: 20.96–42.98%), respectively. The herd and individual prevalence of Q fever antibody in sheep's were 96.07% (95% CI: 89.11–100.00%) and 24.66% (95% CI: 19.81–29.51%), respectively. The herd and individual prevalence of C. burnetii antibody in cattle were 41.37% (95% CI: 17.88–64.86%) and 13.30% (95% CI: 2.98–23.62%), respectively. Individual seropositivity of Q fever in camel and dog were 28.26% (95% CI: 21.47–35.05) and 0.55% (0.03–2.68), respectively. Conclusion Seroprevalence of Q fever among human and domestic animals is considerable. Preventative planning and control of C. burnetii infections in Iran is necessary. Active surveillance and further research studies are recommended, to more clearly define the epidemiology and importance of C. burnetii infections in animals and people in Iran. PMID:28394889

Seroprevalence of Q fever among human and animal in Iran; A systematic review and meta-analysis.

PubMed

Mohabbati Mobarez, Ashraf; Bagheri Amiri, Fahimeh; Esmaeili, Saber

2017-04-01

Q fever is a main zoonotic disease around the world. The aim of this meta-analysis was to estimate the overall seroprevalence of Coxiella burnetii among human and animal population in Iran. Major national and international databases were searched from 2005 up to August 2016. We extracted the prevalence of Q fever antibodies (IgG) as the main primary outcome. We reported the prevalence of the seropositivity as point and 95% confidence intervals. The overall seroprevalence of IgG phase I and II antibodies of Q fever in human was 19.80% (95% CI: 16.35-23.25%) and 32.86% (95% CI: 23.80-41.92%), respectively. The herd and individual prevalence of C. burnetii antibody in goat were 93.42% (95% CI: 80.23-100.00) and 31.97% (95% CI: 20.96-42.98%), respectively. The herd and individual prevalence of Q fever antibody in sheep's were 96.07% (95% CI: 89.11-100.00%) and 24.66% (95% CI: 19.81-29.51%), respectively. The herd and individual prevalence of C. burnetii antibody in cattle were 41.37% (95% CI: 17.88-64.86%) and 13.30% (95% CI: 2.98-23.62%), respectively. Individual seropositivity of Q fever in camel and dog were 28.26% (95% CI: 21.47-35.05) and 0.55% (0.03-2.68), respectively. Seroprevalence of Q fever among human and domestic animals is considerable. Preventative planning and control of C. burnetii infections in Iran is necessary. Active surveillance and further research studies are recommended, to more clearly define the epidemiology and importance of C. burnetii infections in animals and people in Iran.

50 CFR 86.30 - Must I allow the public to use the grant-funded facilities?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Must I allow the public to use the grant-funded facilities? 86.30 Section 86.30 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... INFRASTRUCTURE GRANT (BIG) PROGRAM Public Use of the Facility § 86.30 Must I allow the public to use the grant...

50 CFR 86.31 - How much money may I charge the public to use tie-up facilities?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false How much money may I charge the public to use tie-up facilities? 86.31 Section 86.31 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE... PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Public Use of the Facility § 86.31 How much money may I...

50 CFR 86.73 - What if I do not spend all the money?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What if I do not spend all the money? 86.73 Section 86.73 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE... GRANT (BIG) PROGRAM How States Manage Grants § 86.73 What if I do not spend all the money? Funds not...

Color deviation controlling of phosphor conformal coating by advanced spray painting technology for white LEDs.

PubMed

Yang, Liang; Wang, Simin; Lv, Zhicheng; Liu, Sheng

2013-04-01

An advanced phosphor conformal coating technology is proposed, good correlated color temperature (CCT) and chromaticity uniformity samples are fabricated through phosphor spray painting technology. Spray painting technology is also suitable for phosphor conformal coating of whole LED wafers. The samples of different CCTs are obtained through controlling the phosphor film thickness in the range of 6-80 μm; CCT variation of samples can be controlled in the range of ±200 K. The experimental Δuv reveals that the spray painting method can obtain a much smaller CCT variation (Δuv of 1.36e(-3)) than the conventional dispensing method (Δuv of 11.86e(-3)) when the light is emitted at angles from -90° to +90°, and chromaticity area uniformity is also improved significantly.

[Evaluation of quality of life in school children with a history of early severe malnutrition].

PubMed

De Grandis, E S; Armelini, P A; Cuestas, E

2014-12-01

Severe malnutrition in young children may lead to long-term complications, in particular learning and psychosocial disorders linked to health related quality of life (HRQOL). The aim of this study was to evaluate HRQOL in children whit a history of severe malnutrition before 2 years of life, expecting to find lower scores in these patients. A comparative study was performed on schoolchildren between 5 and 12 years with a history of early severe malnutrition, excluding those with chronic diseases. The Controls were healthy siblings of patients. The sample size was estimated as 26 subjects per group (Total=52). Sociodemographic variables were recorded and the HRQOL was assessed with PedsQL4.0. Chi square and Student t test were applied. Significance level: P<.05. A total of 25 patients and 28 controls were studied. The HRQOL scores obtained from PedsQL for children with history of malnutrition, compared with their healthy siblings, were: Total: 80.82±1.94 vs 89.18±1.84 P<.0001), physical health/dimension: 87.75±3.37 vs 94.75±1.87 (P<.0001), psychosocial health: 77.77±2.90 vs 86.57±1.42 (P<.0001), emotional dimension: 67.80±4.40 vs 78.75±2.96 (P<.0001), social dimension: 88.80±3.05 vs 95.71±1.52 (P<.0001), and school dimension: 74.58±3.80 vs 85.00±3.51 (P<.0001). Patients with a history of early severe malnutrition, showed significantly lower HRQOL scores compared with controls. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

50 CFR 86.43 - May someone else supply the match?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false May someone else supply the match? 86.43 Section 86.43 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.133 - What are the plan standards?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the plan standards? 86.133 Section 86.133 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.14 - Who may apply for these grants?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Who may apply for these grants? 86.14 Section 86.14 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.44 - What are my allowable costs?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are my allowable costs? 86.44 Section 86.44 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.110 - What does the State survey do?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What does the State survey do? 86.110 Section 86.110 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.82 - What must be in the reports?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What must be in the reports? 86.82 Section 86.82 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.50 - When must I apply?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false When must I apply? 86.50 Section 86.50 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM How...

50 CFR 86.42 - What are the match requirements?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the match requirements? 86.42 Section 86.42 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.15 - How does the grant process work?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false How does the grant process work? 86.15 Section 86.15 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.131 - Must I do a plan?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Must I do a plan? 86.131 Section 86.131 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM How...

50 CFR 86.71 - How will I be reimbursed?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false How will I be reimbursed? 86.71 Section 86.71 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

50 CFR 86.45 - When will I receive the funds?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false When will I receive the funds? 86.45 Section 86.45 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG...

Development of a Low Cost Graphics Terminal.

ERIC Educational Resources Information Center

Lehr, Ted

1985-01-01

Describes modifications made to expand the capabilities of a display unit (Lear Siegler ADM-3A) to include medium resolution graphics. The modifying circuitry is detailed along with software subroutined written in Z-80 machine language for controlling the video display. (JN)

R-LOCUS DELETERIOUS FACTORS IN MORMONIELLA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whiting, P.W.

1962-01-01

New data are presented on 37 R-locus mutant genes containing deleterious factors or crossover suppressors. Twenty-seven of these genes are among the 206 recognizable eye-color mutants previously found by others in experiments in which wild-type males were irradiated and mated, siring 11062 daughters examined, mutation rate 1.86%. With the addition of eight mutants from later simdlar tests there were 38 mutants failing to breed, probably being dominant steriles, and seven immature, probably dominant lethals. Of the l60 mutants given successful breeding test, 80 were normal and 80 contained delcterious factors of different types - lethals, near-steriles, femalesteriles, and male-stertles. Ratemore » of deleterious factor productdon differs according to the factor mutating to produce the eye-color marker. Among the l07 genes changed in factor S alone, 68 were also deleterious (63.6%) but for the 45 in O, there were only nine (20.0%), suggesting a more sensitive region near S. More than one deleterious factor may be produced simultaneously with an eye-color change and one defeet may mask others. The gene which forms a temporary unit of segregation in heterozygotes is of a higher order of magnitude than units of heredity (gene elements, cistrons) which may be permanently present dn the germ plasm. Because of the high mutation rate to the marker eye colors scarlet and oyster white, the genetical structure of the R region may be easily studied. (auth)« less

Use of health information technology by children's hospitals in the United States.

PubMed

Menachemi, Nir; Brooks, Robert G; Schwalenstocker, Ellen; Simpson, Lisa

2009-01-01

The purpose of this study was to examine the adoption of health information technology by children's hospitals and to document barriers and priorities as they relate to health information technology adoption. Primary data of interest were obtained through the use of a survey instrument distributed to the chief information officers of 199 children's hospitals in the United States. Data were collected on current and future use of a variety of clinical health information technology and telemedicine applications, organizational priorities, barriers to use of health information technology, and hospital and chief information officer characteristics. Among the 109 responding hospitals (55%), common clinical applications included clinical scheduling (86.2%), transcription (85.3%), and pharmacy (81.9%) and laboratory (80.7%) information. Electronic health records (48.6%), computerized order entry (40.4%), and clinical decision support systems (35.8%) were less common. The most common barriers to health information technology adoption were vendors' inability to deliver products or services to satisfaction (85.4%), lack of staffing resources (82.3%), and difficulty in achieving end-user acceptance (80.2%). The most frequent priority for hospitals was to implement technology to reduce medical errors or to promote safety (72.5%). This first national look at health information technology use by children's hospitals demonstrates the progress in health information technology adoption, current barriers, and priorities for these institutions. In addition, the findings can serve as important benchmarks for future study in this area.

Differential activation of peritoneal cells by subcutaneous treatment of rats with cryptococcal antigens.

PubMed

Baronetti, José L; Chiapello, Laura S; Garro, Ana P; Masih, Diana T

2009-08-01

Previous studies in our laboratory have shown that the subcutaneous pretreatment of rats with heat-killed cells (HKC) of Cryptococcus neoformans emulsified in complete Freund adjuvant (CFA) promotes protective immunity against an intraperitoneal challenge with C. neoformans. In contrast, subcutaneous treatment with the capsular polysaccharide (PSC) emulsified in CFA exacerbates the cryptococcal infection. The purpose of this study was to analyze the mechanisms involved in these phenomena. Adherent peritoneal cells from rats treated with HKC-CFA showed upregulated ED2, CD80, and CD86 expression; an increase in the level of production of anticryptococcal metabolites; and the enhanced production of interleukin-12 (IL-12) in comparison with the findings for cells from rats treated with CFA-phosphate-buffered saline (PBS). Adherent peritoneal cells from rats treated with PSC-CFA, however, also presented upregulated ED2, CD80, and CD86 expression compared to the level of expression for peritoneal cells from controls, but these cells showed an increase in arginase activity and decreased levels of production of IL-12 and tumor necrosis factor (TNF) compared with the activity and levels of production by peritoneal cells from CFA-PBS-treated rats. In addition, treatment with HKC-CFA resulted in a rise in the phagocytic and anticryptococcal activities of adherent peritoneal cells compared to those for control rats. However, adherent peritoneal cells from rats treated with PSC-CFA presented a reduction in anticryptococcal activity in comparison with that for cells from animals treated with CFA-PBS. These results show the differential activation between adherent peritoneal cells from HKC-CFA- and PSC-CFA-treated rats, with this differential activation at the primary site of infection possibly being responsible, at least in part, for the phenomena of protection and exacerbation observed in our model.

Enhanced Motor Imagery-Based BCI Performance via Tactile Stimulation on Unilateral Hand.

PubMed

Shu, Xiaokang; Yao, Lin; Sheng, Xinjun; Zhang, Dingguo; Zhu, Xiangyang

2017-01-01

Brain-computer interface (BCI) has attracted great interests for its effectiveness in assisting disabled people. However, due to the poor BCI performance, this technique is still far from daily-life applications. One of critical issues confronting BCI research is how to enhance BCI performance. This study aimed at improving the motor imagery (MI) based BCI accuracy by integrating MI tasks with unilateral tactile stimulation (Uni-TS). The effects were tested on both healthy subjects and stroke patients in a controlled study. Twenty-two healthy subjects and four stroke patients were recruited and randomly divided into a control-group and an enhanced-group. In the control-group, subjects performed two blocks of conventional MI tasks (left hand vs. right hand), with 80 trials in each block. In the enhanced-group, subjects also performed two blocks of MI tasks, but constant tactile stimulation was applied on the non-dominant/paretic hand during MI tasks in the second block. We found the Uni-TS significantly enhanced the contralateral cortical activations during MI of the stimulated hand, whereas it had no influence on activation patterns during MI of the non-stimulated hand. The two-class BCI decoding accuracy was significantly increased from 72.5% (MI without Uni-TS) to 84.7% (MI with Uni-TS) in the enhanced-group ( p < 0.001, paired t -test). Moreover, stroke patients in the enhanced-group achieved an accuracy >80% during MI with Uni-TS. This novel approach complements the conventional methods for BCI enhancement without increasing source information or complexity of signal processing. This enhancement via Uni-TS may facilitate clinical applications of MI-BCI.

A Multi-center Study on Improvement in Life Quality of Pediatric Patients with Asthma via Continuous Care

PubMed Central

CAI, Ying; CAO, Junhua; KAN, Ruixue; LIU, Yuping; ZHAO, Li; HU, Ming; ZHANG, Xuemei

2017-01-01

Background: To analyze and summarize the effect of continuous care on the life quality and control of asthma of pediatric patients with asthma discharged from multiple hospitals. Methods: Retrospective analysis was carried out on 172 pediatric patients with asthma aged between 6 and 11 yr old randomly selected from those admitted to five hospitals between January 2014 and December 2015. Among these 172 patients, only 86 (intervention group) received the continuous care between January 2015 and December 2015, while the rest (control group) did not receive from January 2014 and December 2014. Results: After the patients in the intervention group were discharged from the hospital, the ratio of practical forced expiratory volume in one second (FEV1) to the expected FEV1 at the 12th month was (90.28±10.35)%, and the ratio of peak expiratory flow to the expected value was (84.24±3.43)%, respectively higher than those [(82.73±8.86)% and (75.80±4.67)%] in the control group. Regarding pediatric asthma quality of life questionnaire (PAQLQ) between the intervention group and the control group, the difference had statistical significance (Z=−7.254, P<0.05). Childhood asthma control test (C-ACT) comparison between the intervention group and the control group indicated that the difference had statistical significance (Z=−7.918, P<0.05). Conclusion: Continuous care can improve the pediatric patient’s pulmonary function and life quality, and effectively control the asthmatic symptoms. PMID:29167770

Nerve-sparing technique and urinary control after robot-assisted laparoscopic prostatectomy.

PubMed

Choi, Wesley W; Freire, Marcos P; Soukup, Jane R; Yin, Lei; Lipsitz, Stuart R; Carvas, Fernando; Williams, Stephen B; Hu, Jim C

2011-02-01

To characterize determinants of 4-, 12-, and 24-month urinary control after robot-assisted laparoscopic prostatectomy (RALP). Adjusted comparative study using prospectively collected, patient self-reported urinary control for 602 consecutive RALPs. Urinary control defined as: (1) EPIC urinary function (UF) scored from 0 to 100 and (2) continence (zero pads per day). Both UF (62.8 vs. 42.4, P<0.001) and continence rates (47.2 vs. 26.7%, P=0.043) were better for bilateral nerve-sparing (BNS) vs. non-nerve-sparing (NNS) at 4 months, but only UF scores were significantly better at 12- (80.9 vs. 70.7, P=0.014) and 24-month (89.2 vs. 77.4, P=0.024) post-RALP. No difference in positive margin rates was observed. In multivariate analysis, older age (parameter estimate -0.42, 95% CI -0.80 to -0.04) and increasing gland volume (-0.13, CI -0.26 to -0.01) resulted in lower UF scores at 4 months, while higher pre-operative UF (0.25, CI 0.05-0.46), bladder neck-sparing technique (10.1, CI 3.79-16.35), BNS (19.1, CI 9.37-28.82), and unilateral nerve-sparing (19.00, CI 7.88-30.11) resulted in higher UF scores at 4 months. At 12 months, higher pre-operative UF (0.24, CI 0.083-0.40) and BNS (9.54, CI 1.92-17.16) resulted in higher UF scores. At 24 months, higher pre-operative UF (0.20, CI 0.06-0.33), bladder neck-sparing technique (7.80, CI 3.48-12.10), and BNS (7.86, CI 1.04-14.68) resulted in higher UF scores. BNS, bladder neck-sparing technique, and higher pre-operative UF score result in improved 24-month urinary control after RALP.

Religiosity, self-control, and virginity status in college students from the “Bible Belt”: a research note.

PubMed

Vazsonyi, Alexander T; Jenkins, Dusty D

2010-01-01

Using a sample of college students (N = 904) from the "Bible Belt," this study examines the effect of religiosity and self-control on late adolescents' delay in initiating sexual intercourse or oral sex. Findings from logistic regressions provide evidence that for each one unit increase in self-control, the odds of a male remaining a virgin or of delaying oral sex increased by a factor of 1.82 and 2.84, respectively, while for females, the odds of not engaging in oral sex increased by a factor of 1.67. In addition to the effect of self-control, a one unit increase in religiosity results in the odds of a male remaining a virgin by a factor of 3.86 and 3.30, respectively. For females the odds are increased by a factor of 4.13 and 2.60, respectively. Mediation tests also provided evidence that self-control mediated the effects by religiosity on both dependent measures. Thus, both religiosity and self-control independently and additively function as key social control mechanisms that promote late adolescent health.

The combined use of 87Sr/86Sr and carbon and water isotopes to study the hydrochemical interaction between groundwater and lakewater in mantled karst

NASA Astrophysics Data System (ADS)

Katz, Brian G.; Bullen, Thomas D.

1996-12-01

The hydrochemical interaction between groundwater and lakewater influences the composition of water that percolates downward from the surficial aquifer system through the underlying intermediate confining unit and recharges the Upper Floridan aquifer along highlands in Florida. The 87Sr/86Sr ratio along with the stable isotopes, D, 18O, and 13C were used as tracers to study the interaction between groundwater, lakewater, and aquifer minerals near Lake Barco, a seepage lake in the mantled karst terrane of northern Florida. Upgradient from the lake, the 87Sr/86Sr ratio of groundwater decreases with depth (mean values of 0.71004, 0.70890, and 0.70852 for water from the surficial aquifer system, intermediate confining unit, and Upper Floridan aquifer, respectively), resulting from the interaction of dilute oxygenated recharge water with aquifer minerals that are less radiogenic with depth. The concentrations of Sr2+ generally increase with depth, and higher concentrations of Sr2+ in water from the Upper Floridan aquifer (20-35 μg/L), relative to water from the surficial aquifer system and the intermediate confining unit, result from the dissolution of Sr-bearing calcite and dolomite in the Eocene limestone. Dissolution of calcite [δ13C= -1.6permil(‰)] is also indicated by an enriched δ13CDIC(-8.8 to -11.4 ‰) in water from the Upper Floridan aquifer, relative to the overlying hydrogeologic units (δ13CDIC< -16‰). Groundwater downgradient from Lake Barco was enriched in18O and D relative to groundwater upgradient from the lake, indicating mixing of lakewater leakage and groundwater. Downgradient from the lake, the 87Sr/86Sr ratio of groundwater and aquifer material become less radiogenic and the Sr2+ concentrations generally increase with depth. However, Sr2+ concentrations are substantially less than in upgradient groundwaters at similar depths. The lower Sr2+ concentrations result from the influence of anoxic lakewater leakage on the mobility of Sr2+ from clays. Based on results from mass-balance modeling, it is probable that cation exchange plays the dominant role in controlling the 87Sr/86Sr ratio of groundwater, both upgradient and downgradient from Lake Barco. Even though groundwater from the three distinct hydrogeologic units displays considerable variability in Sr concentration and isotopic composition, the dominant processes associated with the mixing of lakewater leakage with groundwater, as well as the effects of mineral-water interaction, can be ascertained by integrating the use of stable and radiogenic isotopic measurements of groundwater, lakewater, and aquifer minerals.

Evaluation of peripheral metabolic status by determination of Na-K ATPase pump activity in circulating erythrocytes in patients with thyroid diseases and nonthyroidal illnesses.

PubMed

Ogasawara, H; Nishikawa, M

1993-02-01

The number of Na-K ATPase units in erythrocytes (RBC) was determined by the maximal ouabain binding assay in 25 normal subjects and patients with hyperthyroidism (n = 29), hypothyroidism (8), chronic renal failure (CRF, 19) and with neoplastic disorders (NP, 12). The activity of the pump units was also assessed by measuring ouabain-sensitive 86Rb uptake in some of these subjects. In addition, it was determined in mononuclear cells in normal controls and patients with hyper- and hypothyroidism and CRF. Significant diminution of the number of the RBC pump units was found in hyperthyroidism, while it was increased in hypothyroidism. The binding (O) of old RBC was significantly lower than that (Y) of young RBC and a striking correlation was observed between the % reduction rate ((Y-O)/Y) of the binding and the serum T4 level in hyperthyroidism (r = 0.85, P < 0.02). No difference was observed in pump units of mononuclear cells in normal and hyper- and hypothyroidism. It is suggested that the thyroid hormone- mediated disappearance of the pump units in RBC may play a role in reducing the number of pump units in RBC in hyperthyroidism. The ratio of RBC 86Rb uptake to the number of the pump units in the same cell (U/B) bore a significant relation to serum T3 (r = 0.48, P < 0.05) and T4 (r = 0.49, P < 0.05) indicating that the U/B is a useful index for the peripheral metabolic status. In CRF patients with low T3 levels, bindings were increased but those in NP with low T3 was almost normal.(ABSTRACT TRUNCATED AT 250 WORDS)

40 CFR 86.447-2006 - What provisions apply to motorcycle engines below 50 cc that are certified under the Small SI...

Code of Federal Regulations, 2010 CFR

2010-07-01

... to recall them under 40 CFR part 86, 90, or 1068. (d) Specific requirements. If you are an engine or... family's total sales in the United States are used in highway motorcycles. This includes engines used in...'s total sales in the United States are highway motorcycles. Show that you meet the engine-sales...

Concurrent Chemo-Radiation With or Without Induction Gemcitabine, Carboplatin, and Paclitaxel: A Randomized, Phase 2/3 Trial in Locally Advanced Nasopharyngeal Carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, Terence, E-mail: trdtwk@nccs.com.sg; Lim, Wan-Teck; Fong, Kam-Weng

Purpose: To compare survival, tumor control, toxicities, and quality of life of patients with locally advanced nasopharyngeal carcinoma (NPC) treated with induction chemotherapy and concurrent chemo-radiation (CCRT), against CCRT alone. Patients and Methods: Patients were stratified by N stage and randomized to induction GCP (3 cycles of gemcitabine 1000 mg/m{sup 2}, carboplatin area under the concentration-time-curve 2.5, and paclitaxel 70 mg/m{sup 2} given days 1 and 8 every 21 days) followed by CCRT (radiation therapy 69.96 Gy with weekly cisplatin 40 mg/m{sup 2}), or CCRT alone. The accrual of 172 was planned to detect a 15% difference in 5-year overall survival (OS) with a 5%more » significance level and 80% power. Results: Between September 2004 and August 2012, 180 patients were accrued, and 172 (GCP 86, control 86) were analyzed by intention to treat. There was no significant difference in OS (3-year OS 94.3% [GCP] vs 92.3% [control]; hazard ratio 1.05; 1-sided P=.494]), disease-free survival (hazard ratio 0.77, 95% confidence interval 0.44-1.35, P=.362), and distant metastases–free survival (hazard ratio 0.80, 95% confidence interval 0.38-1.67, P=.547) between the 2 arms. Treatment compliance in the induction phase was good, but the relative dose intensity for concurrent cisplatin was significantly lower in the GCP arm. Overall, the GCP arm had higher rates of grades 3 and 4 leukopenia (52% vs 37%) and neutropenia (24% vs 12%), but grade 3 and 4 acute radiation toxicities were not statistically different between the 2 arms. The global quality of life scores were comparable in both arms. Conclusion: Induction chemotherapy with GCP before concurrent chemo-irradiation did not improve survival in locally advanced NPC.« less

Glycaemic control and hypoglycaemia during 12 months of randomized treatment with insulin glargine 300 U/mL versus glargine 100 U/mL in people with type 1 diabetes (EDITION 4)

PubMed Central

Bergenstal, Richard M.; Bolli, Geremia B.; Ziemen, Monika; Rojeski, Maria; Espinasse, Melanie; Riddle, Matthew C.

2017-01-01

Aims Insulin glargine 300 U/mL (Gla‐300) offers a flatter pharmacodynamic profile than insulin glargine 100 U/mL (Gla‐100). We have compared these insulins over 1 year in people with type 1 diabetes (T1DM). Methods EDITION 4 was a 6‐month, multicentre, randomized, open‐label phase 3 study. People with T1DM who completed the 6 months continued randomized Gla‐300 or Gla‐100 once daily, morning or evening, for a further 6 months. Results Among 549 participants randomized, 444 completed the 12‐month study period (Gla‐300, 80%; Gla‐100, 82%). Mean HbA1c decreased similarly from baseline to month 12 in the 2 treatment groups (difference, 0.02 [95% CI, −0.13 to 0.17]) %‐units [0.2 (−1.5 to 1.9) mmol/mol]), to a mean of 7.86 %‐units (62.4 mmol/mol) in both groups. For morning vs evening injection, there was no difference in HbA1c change over 12 months for Gla‐100, but a significantly larger decrease in HbA1c was observed in the Gla‐300 morning group than in the Gla‐300 evening group (difference, −0.25 [−0.47 to −0.04] %‐units [−2.7 (−5.2 to −0.4) mmol/mol]). Mean glucose from the 8‐point SMPG profiles decreased from baseline, and was similar between the 2 treatment groups. Basal insulin dose was 20% higher with Gla‐300 than with Gla‐100, while hypoglycaemia event rates, analysed at night, over 24 hours, or according to different glycaemic thresholds, did not differ between treatment groups, regardless of injection time. Adverse event profiles did not differ between groups. Conclusions In T1DM, Gla‐300 provides glucose control comparable to that of Gla‐100, and can be given at any time of day. PMID:28661585

Glycaemic control and hypoglycaemia during 12 months of randomized treatment with insulin glargine 300 U/mL versus glargine 100 U/mL in people with type 1 diabetes (EDITION 4).

PubMed

Home, Philip D; Bergenstal, Richard M; Bolli, Geremia B; Ziemen, Monika; Rojeski, Maria; Espinasse, Melanie; Riddle, Matthew C

2018-01-01

Insulin glargine 300 U/mL (Gla-300) offers a flatter pharmacodynamic profile than insulin glargine 100 U/mL (Gla-100). We have compared these insulins over 1 year in people with type 1 diabetes (T1DM). EDITION 4 was a 6-month, multicentre, randomized, open-label phase 3 study. People with T1DM who completed the 6 months continued randomized Gla-300 or Gla-100 once daily, morning or evening, for a further 6 months. Among 549 participants randomized, 444 completed the 12-month study period (Gla-300, 80%; Gla-100, 82%). Mean HbA1c decreased similarly from baseline to month 12 in the 2 treatment groups (difference, 0.02 [95% CI, -0.13 to 0.17]) %-units [0.2 (-1.5 to 1.9) mmol/mol]), to a mean of 7.86 %-units (62.4 mmol/mol) in both groups. For morning vs evening injection, there was no difference in HbA1c change over 12 months for Gla-100, but a significantly larger decrease in HbA1c was observed in the Gla-300 morning group than in the Gla-300 evening group (difference, -0.25 [-0.47 to -0.04] %-units [-2.7 (-5.2 to -0.4) mmol/mol]). Mean glucose from the 8-point SMPG profiles decreased from baseline, and was similar between the 2 treatment groups. Basal insulin dose was 20% higher with Gla-300 than with Gla-100, while hypoglycaemia event rates, analysed at night, over 24 hours, or according to different glycaemic thresholds, did not differ between treatment groups, regardless of injection time. Adverse event profiles did not differ between groups. In T1DM, Gla-300 provides glucose control comparable to that of Gla-100, and can be given at any time of day. © 2017 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

50 CFR 86.55 - What are my compliance requirements with Federal laws, regulations, and policies?

Code of Federal Regulations, 2010 CFR

2010-10-01

... Federal laws, regulations, and policies? 86.55 Section 86.55 Wildlife and Fisheries UNITED STATES FISH AND... compliance requirements with Federal laws, regulations, and policies? (a) To receive Federal funds, you must agree to and certify compliance with all applicable Federal laws, regulations, and policies. You must...

50 CFR 86.55 - What are my compliance requirements with Federal laws, regulations, and policies?

Code of Federal Regulations, 2013 CFR

2013-10-01

... Federal laws, regulations, and policies? 86.55 Section 86.55 Wildlife and Fisheries UNITED STATES FISH AND... compliance requirements with Federal laws, regulations, and policies? (a) To receive Federal funds, you must agree to and certify compliance with all applicable Federal laws, regulations, and policies. You must...

50 CFR 86.55 - What are my compliance requirements with Federal laws, regulations, and policies?

Code of Federal Regulations, 2014 CFR

2014-10-01

... Federal laws, regulations, and policies? 86.55 Section 86.55 Wildlife and Fisheries UNITED STATES FISH AND... compliance requirements with Federal laws, regulations, and policies? (a) To receive Federal funds, you must agree to and certify compliance with all applicable Federal laws, regulations, and policies. You must...

50 CFR 86.55 - What are my compliance requirements with Federal laws, regulations, and policies?

Code of Federal Regulations, 2011 CFR

2011-10-01

... Federal laws, regulations, and policies? 86.55 Section 86.55 Wildlife and Fisheries UNITED STATES FISH AND... compliance requirements with Federal laws, regulations, and policies? (a) To receive Federal funds, you must agree to and certify compliance with all applicable Federal laws, regulations, and policies. You must...

50 CFR 86.55 - What are my compliance requirements with Federal laws, regulations, and policies?

Code of Federal Regulations, 2012 CFR

2012-10-01

... Federal laws, regulations, and policies? 86.55 Section 86.55 Wildlife and Fisheries UNITED STATES FISH AND... compliance requirements with Federal laws, regulations, and policies? (a) To receive Federal funds, you must agree to and certify compliance with all applicable Federal laws, regulations, and policies. You must...

45 CFR 86.13 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Military and merchant marine educational... Coverage § 86.13 Military and merchant marine educational institutions. This part does not apply to an... United States or for the merchant marine. (Secs. 901, 902, Education Amendments of 1972, 86 Stat. 373...

45 CFR 86.13 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Military and merchant marine educational... Coverage § 86.13 Military and merchant marine educational institutions. This part does not apply to an... United States or for the merchant marine. (Secs. 901, 902, Education Amendments of 1972, 86 Stat. 373...

45 CFR 86.13 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Military and merchant marine educational... Coverage § 86.13 Military and merchant marine educational institutions. This part does not apply to an... United States or for the merchant marine. (Secs. 901, 902, Education Amendments of 1972, 86 Stat. 373...

50 CFR 86.82 - What must be in the reports?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What must be in the reports? 86.82 Section 86.82 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the...

Isotopic imprints of mountaintop mining contaminants.

PubMed

Vengosh, Avner; Lindberg, T Ty; Merola, Brittany R; Ruhl, Laura; Warner, Nathaniel R; White, Alissa; Dwyer, Gary S; Di Giulio, Richard T

2013-09-03

Mountaintop mining (MTM) is the primary procedure for surface coal exploration within the central Appalachian region of the eastern United States, and it is known to contaminate streams in local watersheds. In this study, we measured the chemical and isotopic compositions of water samples from MTM-impacted tributaries and streams in the Mud River watershed in West Virginia. We systematically document the isotopic compositions of three major constituents: sulfur isotopes in sulfate (δ(34)SSO4), carbon isotopes in dissolved inorganic carbon (δ(13)CDIC), and strontium isotopes ((87)Sr/(86)Sr). The data show that δ(34)SSO4, δ(13)CDIC, Sr/Ca, and (87)Sr/(86)Sr measured in saline- and selenium-rich MTM impacted tributaries are distinguishable from those of the surface water upstream of mining impacts. These tracers can therefore be used to delineate and quantify the impact of MTM in watersheds. High Sr/Ca and low (87)Sr/(86)Sr characterize tributaries that originated from active MTM areas, while tributaries from reclaimed MTM areas had low Sr/Ca and high (87)Sr/(86)Sr. Leaching experiments of rocks from the watershed show that pyrite oxidation and carbonate dissolution control the solute chemistry with distinct (87)Sr/(86)Sr ratios characterizing different rock sources. We propose that MTM operations that access the deeper Kanawha Formation generate residual mined rocks in valley fills from which effluents with distinctive (87)Sr/(86)Sr and Sr/Ca imprints affect the quality of the Appalachian watersheds.

24 CFR 3280.811 - Calculations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... including 4 or more separately controlled space heating loads. (4) The nameplate ampere or kVA rating of all... electric space heating 65 Less than 4 separately controlled electric space heating units 65 1st 10 kW of... 80 percent of rating. 10,001 to 12,500 8,000. 12,501 to 13,500 8,400. 13,501 to 14,500 8,800. 14,501...

24 CFR 3280.811 - Calculations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... including 4 or more separately controlled space heating loads. (4) The nameplate ampere or kVA rating of all... electric space heating 65 Less than 4 separately controlled electric space heating units 65 1st 10 kW of... 80 percent of rating. 10,001 to 12,500 8,000. 12,501 to 13,500 8,400. 13,501 to 14,500 8,800. 14,501...

24 CFR 3280.811 - Calculations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... including 4 or more separately controlled space heating loads. (4) The nameplate ampere or kVA rating of all... electric space heating 65 Less than 4 separately controlled electric space heating units 65 1st 10 kW of... 80 percent of rating. 10,001 to 12,500 8,000. 12,501 to 13,500 8,400. 13,501 to 14,500 8,800. 14,501...

Mid-late Holocene variability of TEX86 temperature on the inner shelf of the East China Sea

NASA Astrophysics Data System (ADS)

Wu, X.; Xing, L.; Zhang, T.; Li, L.

2017-12-01

To understand the long-term environmental evolution of the East China Sea (ECS) and adjacent areas, decadal sea surface temperature (SST) induced by TEX86 (tetraether index of tetraethers consisting of 86 carbons) index was reconstructed in Core T08 on the inner shelf of the ECS over the past 3725 years. Core-top TEXH86 temperature was 23.2 °, close to the mean annual SST 22.9 ° at Site T08. BIT (branched and isopreniod tetraether) index and GDGT-0/GDGT-5 ratio indicated that the influences of terrestrial input and methanogens were negligible on TEX86 index, respectively. During the period of 3725-2000 yr BP, TEXH86 temperature had low values, fluctuating around 20 °, which suggested the weakened Kuroshio Current (KC) or the eastward shifting of the KC axis. From 2000 to 750 yr BP, TEXH86 temperature gradually increased to 23 °, indicating enhanced KC influence on Site T08. Significant reduction of TEXH86 temperature around 400 yr BP corresponded to Little Ice Age (LIA). Spectral analysis reveals that TEXH86 temperature series exhibit 175, 80, and 68-year periodicities, consistent with the characteristic periodicities of solar activity.

Exploratory Study of the Potential Effects of Exposure to Sonic Boom on Human Health. Volume 1. Sonic Boom Environment.

DTIC Science & Technology

1986-06-01

63 SPARKS 621 10.46 0.80 0.0 35. 3 0.19v, 64 VERDI 73 0.68 0.80 0.0 23 4 ,.01,3 65 WADSWORTH 730 10.70 0.80 0.0 35. 4 (..󈧇 67 HAKER 1168 1.47 0.80...Q. , HAKER 1168 10.68 0.82 3584.1 5.6 4 48 H Ft y 7190 51.23 0.83 3563.1 iY.4 7.I 3 o9 LUNi 694 %.51 0.81 3631.5 32.6 .. , II)t. 109889 󈧕.86 100

45 CFR 1356.80 - Scope of the National Youth in Transition Database.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 4 2011-10-01 2011-10-01 false Scope of the National Youth in Transition Database... REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.80 Scope of the National Youth in Transition Database. The requirements of the National Youth in Transition Database (NYTD) §§ 1356.81 through 1356.86 of this part apply...

45 CFR 1356.80 - Scope of the National Youth in Transition Database.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Scope of the National Youth in Transition Database... REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.80 Scope of the National Youth in Transition Database. The requirements of the National Youth in Transition Database (NYTD) §§ 1356.81 through 1356.86 of this part apply...

45 CFR 1356.80 - Scope of the National Youth in Transition Database.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Scope of the National Youth in Transition Database... REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.80 Scope of the National Youth in Transition Database. The requirements of the National Youth in Transition Database (NYTD) §§ 1356.81 through 1356.86 of this part apply...

45 CFR 1356.80 - Scope of the National Youth in Transition Database.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Scope of the National Youth in Transition Database... REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.80 Scope of the National Youth in Transition Database. The requirements of the National Youth in Transition Database (NYTD) §§ 1356.81 through 1356.86 of this part apply...

45 CFR 1356.80 - Scope of the National Youth in Transition Database.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 4 2014-10-01 2014-10-01 false Scope of the National Youth in Transition Database... REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.80 Scope of the National Youth in Transition Database. The requirements of the National Youth in Transition Database (NYTD) §§ 1356.81 through 1356.86 of this part apply...

Why are Chinese Mothers More Controlling than American Mothers? “My Child is My Report Card”

PubMed Central

Ng, Florrie Fei-Yin; Pomerantz, Eva M.; Deng, Ciping

2013-01-01

Chinese parents exert more control over children than do American parents. The current research examined whether this is due in part to Chinese parents' feelings of worth being more contingent on children's performance. Twice over a year, 215 mothers and children (mean age = 12.86 years) in China and the United States (European and African Americans) reported on psychologically controlling parenting. Mothers also indicated the extent to which their worth is contingent on children's performance. Psychologically controlling parenting was higher among Chinese than American mothers, particularly European (vs. African) American mothers. Chinese (vs. American) mothers' feelings of worth were more contingent on children's performance, with this contributing to their heightened psychological control relative to American mothers. PMID:23581633

Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases.

PubMed

Heytens, S; De Sutter, A; Coorevits, L; Cools, P; Boelens, J; Van Simaey, L; Christiaens, T; Vaneechoutte, M; Claeys, G

2017-09-01

Our objective was to examine whether or not women with symptoms of a urinary tract infection but with a negative culture (20%-30%) do have an infection. We performed quantitative PCR (qPCR) for Escherichia coli and Staphylococcus saprophyticus, on top of a standard culture, in urine samples from 220 women with dysuria and/or frequency and/or urgency and from 86 women without symptoms. For symptomatic women, qPCR was also carried out for four sexually transmitted agents. In the symptomatic group, 80.9% (178/220) of the urine cultures were positive for any uropathogen and 95.9% (211/220) were E. coli qPCR-positive. For the control group, cultures for E. coli and E. coli qPCR were positive in, respectively, 10.5% (9/86) and 11.6% (10/86). In the symptomatic group, qPCR yielded 19 positive samples for S. saprophyticus qPCR, one positive sample for Mycoplasma genitalium and one for Trichomonas vaginalis. These findings suggest that almost all women with typical urinary complaints and a negative culture still have an infection with E. coli. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Design of automatic mobile trolley using ultrasonic sensors

NASA Astrophysics Data System (ADS)

Dodi Suryanto, Eka; Siagian, Hendrik; Perangin-Angin, Despaleri; Sashanti, Rahayu; Yogen, Suthes

2018-04-01

An automatic mobile trolley was a prototype of wheel robot that serves as a trolley or shopping cart. This paper proposed an automatic mobile trolley using ultrasonic sensors. It can follow human movement automatically. It did not need to be encouraged or withdrawn. It would make an easier shopping for people as customers. The trolley controlled by a microcontroller module unit. It can stop, turn right, turn left, forward and backward. It can follow wherever they go, during they were in range. Based on the test results, the trolley succeeded to move forward by 80%, move backward 80%, turn left, 70%, turn right 70%, and stop 80%.

[Preliminary activities of the program for the control and treatment of onchocerciasis in the Yanomâmi territory, Roraima, Brazil].

PubMed

Coelho, G E; Vieira, J B; Oliveira, C E; Francisco, D A; Pinheiro, L R

1997-01-01

After to characterize the clinic and epidemiological picture of the onchocerciasis in Yanomâmi region, RR, Brazil, begun in 1993, the National Health Foundation (FNS) implemented a Control and Treatment Pilot Project in Tootobi and Balawaú. Here, it was studied skin biopsies from 426 inhabitants. In the nodules of 86.7% from patients was encountered Onchocerca volvulus. The over-all prevalence in the examined population was 66.2%. The treatment with ivermectin covered 80.1% of total population. Adverse reactions, light and moderate, of the medicament were reported in 12.3% of the patients. These results agreeing with the medical literature and suggesting the viability of to increase of the programme for all Yanomâmi area in the next phase.

Turbine Powered Simulator Calibration and Testing for Hybrid Wing Body Powered Airframe Integration

NASA Technical Reports Server (NTRS)

Shea, Patrick R.; Flamm, Jeffrey D.; Long, Kurtis R.; James, Kevin D.; Tompkins, Daniel M.; Beyar, Michael D.

2016-01-01

Propulsion airframe integration testing on a 5.75% scale hybrid wing body model us- ing turbine powered simulators was completed at the National Full-Scale Aerodynamics Complex 40- by 80-foot test section. Four rear control surface con gurations including a no control surface de ection con guration were tested with the turbine powered simulator units to investigate how the jet exhaust in uenced the control surface performance as re- lated to the resultant forces and moments on the model. Compared to ow-through nacelle testing on the same hybrid wing body model, the control surface e ectiveness was found to increase with the turbine powered simulator units operating. This was true for pitching moment, lift, and drag although pitching moment was the parameter of greatest interest for this project. With the turbine powered simulator units operating, the model pitching moment was seen to increase when compared to the ow-through nacelle con guration indicating that the center elevon and vertical tail control authority increased with the jet exhaust from the turbine powered simulator units.

Ducting arrangement for cooling a gas turbine structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Ching-Pang; Morrison, Jay A.

2015-07-21

A ducting arrangement (10) for a can annular gas turbine engine, including: a duct (12, 14) disposed between a combustor (16) and a first row of turbine blades and defining a hot gas path (30) therein, the duct (12, 14) having raised geometric features (54) incorporated into an outer surface (80); and a flow sleeve (72) defining a cooling flow path (84) between an inner surface (78) of the flow sleeve (72) and the duct outer surface (80). After a cooling fluid (86) traverses a relatively upstream raised geometric feature (90), the inner surface (78) of the flow sleeve (72)more » is effective to direct the cooling fluid (86) toward a landing (94) separating the relatively upstream raised geometric feature (90) from a relatively downstream raised geometric feature (94).« less

JPRS Report, East Europe

DTIC Science & Technology

1987-10-05

Voronezh, beginning to produce the modern 11-96 airbus , naturally proposed that the Polish plants participate in the production of this aircraft...Swidnik, and Kalisz, are taking part in the coproduction of the 11-86. From the Mielec plant the jet airbus is provided with engine mounts, units...assemblies, units, and parts for the modern wide-body 11-86 airbus produced in Voronezh. The assemblies produced in Poland utilizing Soviet docu- mentation

Development of a Cross-Flow Fan Powered Quad-Rotor Unmanned Aerial Vehicle

DTIC Science & Technology

2015-06-01

HVAC Heating ventilation and air conditioning LiPo Lithium - ion polymer PLA Polylactic acid, 3-D printer filament PVA Polyvinyl alcohol PREPREG...control console Figure 79. Rheostat speed control console. 74 c) 6 cell lithium polymer battery Figure 80. 6 Cell LiPo battery . 75 d...Radio control system and versatile unit mounted with zip ties. ......................67  Figure 75.  LiPo batteries and parallel battery connector

50 CFR 86.101 - What is the Service schedule to adopt the National Framework?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What is the Service schedule to adopt the National Framework? 86.101 Section 86.101 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... schedule to adopt the National Framework? The Secretary of the Interior adopted the National Framework on...

50 CFR 86.132 - What are the advantages to doing a plan?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are the advantages to doing a plan? 86.132 Section 86.132 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF... advantages to doing a plan? Plans provide the information necessary to fully understand the needs of boaters...

50 CFR 86.113 - What if I have recently completed a boat access survey?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false What if I have recently completed a boat access survey? 86.113 Section 86.113 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... I have recently completed a boat access survey? If the recent survey substantially answers the...

50 CFR 86.113 - What if I have recently completed a boat access survey?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What if I have recently completed a boat access survey? 86.113 Section 86.113 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE... I have recently completed a boat access survey? If the recent survey substantially answers the...

[Health care for adolescents with gender dysphoria].

PubMed

Fernández, María; Guerra, Patricia; Martín, Eloya; Martínez, Noelia; Álvarez-Diz, Jose Antonio

2018-02-28

Dysphoria gender treatment in adolescents is recent. Studies of adolescents treated with analogs are reduced. To ensure the quality of care and safety of the child, follow-up studies are necessary. The aim of the present research was to describe the characteristics of the process of medical and psychological attention in adolescents with the DG in the Gender Identity Treatment Unit of Asturias in the period 2007-2015. The sample included 20 minors attended in the Gender Identity Treatment Unit of Asturias in the period 2007-2015. The clinical history was made to collect the variables. It was made descriptive analysis. 10% of adolescents abandoned in the process of psychological counseling, 80% began to be valued by endocrinology and 10% continued exclusively in psychological consultations. Of the medical treated adolescents, 13.3% were treated with analogues and 86.7% received cross-hormonal treatment (THC) directly. The most prevalent secondary effects were dermatological problems (40%), followed by mastodynia without galactorrhea (26.7%) and hot flashes (20%). 20% performed gender confirmation surgeries. The profile of the adolescent treated in the unit of Asturias is a subject that begins hormonal treatment after psychological accompaniment and endocrinological evaluation. The minor has adverse effects after treatment. Once the hormonal treatment has been established, they do not abandon the process.

Outcomes of preterm neonates with frontal horn cysts: a retrospective study.

PubMed

Trawber, Rory; Rao, Shripada; Srinivasjois, Ravisha; Thonell, Sven; Nagarajan, Lakshmi; French, Noel; Jacoby, Peter; McMichael, Judy

2010-11-01

Isolated paraventricular frontal horn cysts are sometimes encountered on cranial ultrasound examinations of preterm neonates. The etiology and clinical significance of these lesions are unclear. The authors aimed to identify antenatal/intrapartum risk factors associated with the occurrence of these cysts and to assess developmental outcomes of preterm neonates with isolated frontal horn cysts. A retrospective cohort study with matched control design was used. A total of 28 cases were matched for gestation with 56 controls. No antenatal/intrapartum factors were associated with these cysts. At corrected age of 1 year, there was no difference in the mean general quotient between cases and controls (97.75 ± 17.28 vs 94.94 ± 9.86; P = .410). In all, 1 case and no controls had a diagnosis of cerebral palsy and 1 case and 3 controls had general quotients less than 80. The authors conclude that isolated paraventricular frontal horn cysts are benign, with no effect on neurodevelopment.

Acceptance and commitment therapy improves exercise tolerance in sedentary women.

PubMed

Ivanova, Elena; Jensen, Dennis; Cassoff, Jamie; Gu, Fei; Knäuper, Bärbel

2015-06-01

To test the efficacy of an acute intervention derived from acceptance and commitment therapy (ACT) for increasing high-intensity constant work rate (CWR) cycle exercise tolerance in a group of low-active women age 18-45 yr. The secondary goals were to examine whether ACT would reduce perceived effort and improve in-task affect during exercise and increase postexercise enjoyment. In a randomized controlled trial, 39 women were randomized to either the experimental (using ACT-based cognitive techniques and listening to music during the CWR exercise tests) or a control group (listening to music during the CWR exercise tests). Before (CWR-1) and after the intervention (CWR-2), participants completed a CWR cycle exercise test at 80% of maximal incremental work rate (Wmax) until volitional exhaustion. On average, ACT (n = 18) and control (n = 21) groups were matched for age, body mass index, weekly leisure activity scores, and Wmax (all P > 0.05). Exercise tolerance time (ETT) increased by 15% from CWR-1 to CWR-2 for the ACT group (392.05 ± 146.4 vs 459.39 ± 209.3 s; mean ± SD) and decreased by 8% (384.71 ± 120.1 vs 353.86 ± 127.9 s) for the control group (P = 0.008). RPE were lower (e.g., by 1.5 Borg 6-20 scale units at 55% of ETT, P ≤ 0.01) during CWR-2 in the ACT versus that in the control group. By contrast, ACT had no effect on in-task affect. Exercise enjoyment was higher after CWR-2 in the ACT group versus that in the control group (P < 0.001). An acute ACT intervention increased high-intensity ETT and postexercise enjoyment and reduced perceived effort in low-active women. Further investigations of ACT as an effective intervention for enhancing the established health benefits of high-intensity exercise need to be provided.

Temperature minima in the average thermal structure of the middle mesosphere (70 - 80 km) from analysis of 40- to 92-km SME global temperature profiles

NASA Technical Reports Server (NTRS)

Clancy, R. Todd; Rusch, David W.; Callan, Michael T.

1994-01-01

Global temperatures have been derived for the upper stratosphere and mesosphere from analysis of Solar Mesosphere Explorer (SME) limb radiance profiles. The SME temperature represent fixed local time observations at 1400 - 1500 LT, with partial zonal coverage of 3 - 5 longitudes per day over the 1982-1986 period. These new SME temperatures are compared to the COSPAR International Ionosphere Reference Atmosphere 86 (CIRA 86) climatology (Fleming et al., 1990) as well as stratospheric and mesospheric sounder (SAMS); Barnett and Corney, 1984), National Meteorological Center (NMC); (Gelman et al., 1986), and individual lidar and rocket observations. Significant areas of disagreement between the SME and CIRA 86 mesospheric temperatures are 10 K warmer SME temperatures at altitudes above 80 km. The 1981-1982 SAMS temperatures are in much closer agreement with the SME temperatures between 40 and 75 km. Although much of the SME-CIRA 86 disagreement probably stems from the poor vertical resolution of the observations comprising the CIRA 86 modelm, some portion of the differences may reflect 5- to 10-year temporal variations in mesospheric temperatures. The CIRA 86 climatology is based on 1973-1978 measurements. Relatively large (1 K/yr) 5- to 10-year trends in temperatures as functions of longitude, latitude, and altitude have been observed for both the upper stratosphere (Clancy and Rusch, 1989a) and mesosphere (Clancy and Rusch, 1989b; Hauchecorne et al., 1991). The SME temperatures also exhibit enhanced amplitudes for the semiannual oscillation (SAO) of upper mesospheric temperatures at low latitudes, which are not evident in the CIRA 86 climatology. The so-called mesospheric `temperature inversions' at wintertime midlatitudes, which have been observed by ground-based lidar (Hauschecorne et al., 1987) and rocket in situ measurements (Schmidlin, 1976), are shown to be a climatological aspect of the mesosphere, based on the SME observations.

Korean Affairs Report.

DTIC Science & Technology

1986-10-20

Assails Chon’s Linking Explosion With Chongnyon (KCNA, 26 Sep 86) 31 "" 3i "" VNS on Chon Kyong-hwan Bribery Case (Yun Chong- won ; Voice of...Myong-nam; Pyongyang Domestic Service, 25 Sep 86) .. 42 VNS on People’s Rejection of Asiad, Olympics (Ko Il-chol, Min Hye -kyong; Voice of National...86) 109 INTERNATIONAL COMMENTARY United States Accused of Plotting Chemical Warfare (Pak Won -hae; MINJU CH0S0N, 3 Aug 86) 114 /7310 - c

34 CFR 363.5 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

...). (4) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 363. (c) The following...

34 CFR 364.3 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... (Intergovernmental Review of Department of Education Programs and Activities). (6) 34 CFR part 80 (Uniform... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

34 CFR 364.3 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... (Intergovernmental Review of Department of Education Programs and Activities). (6) 34 CFR part 80 (Uniform... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

34 CFR 363.5 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

...). (4) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 363. (c) The following...

34 CFR 363.5 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

...). (4) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 363. (c) The following...

34 CFR 364.3 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... (Intergovernmental Review of Department of Education Programs and Activities). (6) 34 CFR part 80 (Uniform... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

34 CFR 363.5 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

...). (4) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 363. (c) The following...

34 CFR 363.5 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

...). (4) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 363. (c) The following...

34 CFR 364.3 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (Intergovernmental Review of Department of Education Programs and Activities). (6) 34 CFR part 80 (Uniform... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

34 CFR 364.3 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... (Intergovernmental Review of Department of Education Programs and Activities). (6) 34 CFR part 80 (Uniform... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

Induction of allograft tolerance through costimulatory blockade: first selection of drugs in vitro.

PubMed

Vierboom, Michel P M; Ossevoort, Miriam; Sick, Ella A; Haanstra, Krista; Jonker, Margreet

2003-01-01

The development of an in vitro assay predicting the chances of graft survival after treatment with immunoregulatory agents is a major topic in transplantation. Antibodies (Abs) interfering in the costimulatory pathway are promising candidates for the induction of tolerance. To evaluate these antibodies for clinical use studies non-human primates are the only feasible option due to species specificity of the antibodies. Peripheral blood mononuclear cells, isolated from a large panel of rhesus monkeys, were used in a unidirectional mixed lymphocyte reaction to evaluate the ability of antibodies blocking the costimulatory pathway, to affect both primary and secondary proliferative and cytolytic allospecific immune responses in vitro. These blocking antibodies were also used in protocols prolonging allograft survival in a life-supporting kidney allotransplant model in rhesus macaques. The ultimate aim is to establish a correlation between parameters obtained in vitro and the success of transplantation in vivo. The combination of anti-CD80 and anti-CD86 resulted in a complete abrogation of the primary alloresponse as measured in a proliferation assay. Adding anti-CD40 significantly reduced this inhibitory effect although the in vivo effects of this antibody have been shown to be beneficial. The secondary response was most prominently inhibited by the combination of anti-CD80/86. Paradoxically, anti-CD40 alone markedly inhibited the secondary proliferative response, but did not add to the inhibitory effect of the combination of anti-CD80/86. The cytolytic response was inhibited maximally only when CsA was added to the combination of anti-CD80/86. Treatment with monoclonal antibodies alone without immunosuppressive drugs was sufficient to maintain graft survival during the time of treatment in most animals. However, rejection was initiated as soon as the treatment ceased and no tolerance, resulting in long-term graft and patient survival, was established. The complete inhibition of primary alloresponses and the partial inhibition of secondary proliferative alloresponses correlate with prolonged graft survival during treatment, but have no predictive value for the success of tolerance induction for kidney allografts in rhesus monkeys.

Changing sources of strontium to soils and ecosystems across the Hawaiian Islands

USGS Publications Warehouse

Chadwick, O.A.; Derry, L.A.; Bern, C.R.; Vitousek, P.M.

2009-01-01

Strontium isotope ratios assist ecosystem scientists in constraining the sources of alkaline earth elements, but their interpretation can be difficult because of complexities in mineral weathering and in the geographical and environmental controls on elemental additions and losses. Hawaii is a "natural laboratory" where a number of important biogeochemical variables have either limited ranges or vary in systematic ways, providing a unique opportunity to understand the impact of time, climate, and atmospheric inputs on the evolution of base cation sources to ecosystems. There are three major sources of strontium (Sr) to these ecosystems, each with distinct isotopic compositions: basalt lava, Asian dust, and rainfall. We present Sr isotope and concentration data on both bulk soil digests and NH4Ac extracts from soil profiles covering a wide range of environments and substrate ages. Bulk soil material from dry climates and/or young substrate ages with > 80????g g- 1 Sr retain basalt-like Sr isotopic signatures, whereas those with Sr concentrations < 80????g g- 1 can have isotope signatures that range from basalt-like values to the more radiogenic values associated with continental dust. Although both dust accumulation and lava weathering are time- and rainfall-dependent, the overall concentration of Sr drops with increasing leaching even as quartz and mica derived from continental dust sources increase to > 40% by mass. At elevated dust levels, lava-derived Sr is low and dust-derived Sr is the dominant control of 87Sr/86Sr in bulk soils; however, 87Sr/86Sr of NH4Ac-extractable Sr largely reflects atmospheric deposition of marine aerosol in these situations. Overall, whole-soil Sr isotope values are controlled by complex interactions between Sr provided by lava weathering but partially lost by leaching, and Sr provided by dust but held in more resistant minerals. The isotopic composition of NH4Ac-extractable Sr and of the biota is controlled by lava weathering and rainfall contribution of Sr with only minor contributions from radiogenic dust sources. ?? 2009 Elsevier B.V.

Full exploration of the Diels-Alder cycloaddition on metallofullerenes M3N@C80 (M = Sc, Lu, Gd): the D(5h) versus I(h) isomer and the influence of the metal cluster.

PubMed

Osuna, Sílvia; Valencia, Ramón; Rodríguez-Fortea, Antonio; Swart, Marcel; Solà, Miquel; Poblet, Josep M

2012-07-16

In this work a detailed investigation of the exohedral reactivity of the most important and abundant endohedral metallofullerene (EMF) is provided, that is, Sc(3)N@I(h)-C(80) and its D(5h) counterpart Sc(3)N@D(5h)-C(80) , and the (bio)chemically relevant lutetium- and gadolinium-based M(3)N@I(h)/D(5h)-C(80) EMFs (M = Sc, Lu, Gd). In particular, we analyze the thermodynamics and kinetics of the Diels-Alder cycloaddition of s-cis-1,3-butadiene on all the different bonds of the I(h)-C(80) and D(5h)-C(80) cages and their endohedral derivatives. First, we discuss the thermodynamic and kinetic aspects of the cycloaddition reaction on the hollow fullerenes and the two isomers of Sc(3)N@C(80). Afterwards, the effect of the nature of the metal nitride is analyzed in detail. In general, our BP86/TZP//BP86/DZP calculations indicate that [5,6] bonds are more reactive than [6,6] bonds for the two isomers. The [5,6] bond D(5h)-b, which is the most similar to the unique [5,6] bond type in the icosahedral cage, I(h)-a, is the most reactive bond in M(3)N@D(5h)-C(80) regardless of M. Sc(3)N@C(80) and Lu(3)N@C(80) give similar results; the regioselectivity is, however, significantly reduced for the larger and more electropositive M = Gd, as previously found in similar metallofullerenes. Calculations also show that the D(5h) isomer is more reactive from the kinetic point of view than the I(h) one in all cases which is in good agreement with experiments. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Standards for Advisement, Invocation, and Waiver of Counsel in Military Intelligence Interrogations

DTIC Science & Technology

2004-04-01

appointed counsel experienced 288 Id para. 86.1 289 Direccion Nacional contra el Terrorismo . 290 Id para. 86.2. 291 See id. (citing Decree-Law 25,744, art...60 (1st Cir. 2000) ( en banc); United States v. Zabenah, 837 F.2d 1249, 1261 (5th Cir. 1988); Goldstar v. United States, 967 F.2d 965, 968 (4th Cir...Jimenez-Nava, 243 F.3d at 195-98. 135 Jimenez-Nava, 243 F.3d at 198. See also United States v. Lombera-Camorlinga, 206 F.3d 882, 885 (9th Cir. 2000) ( en

Costimulatory molecule expression following exposure to orthopaedic implants wear debris.

PubMed

Bainbridge, J A; Revell, P A; Al-Saffar, N

2001-03-05

Patients with long-term orthopedic implants may develop inflammatory reactions due to the accumulation of biomaterial particles both around the implant and in distant organs. The exact impact of these particles on the normal immune cell function still remain relatively unclear. Activation of T-cells following exposure to biomaterial particles is driven by macrophages and requires synergistic signals primed by both antigen presentation and costimulation. The pattern of costimulatory molecule expression (CD80,CD86) was primarily examined using immunohistochemistry on tissue specimens of bone/implant interface membranes taken from sites of bone erosion. Additionally, costimulatory molecule expression was also assessed in the monocytic leukemia cell line U937 following exposure to clinically relevant titanium aluminum vanadium (TiAlV) and stainless steel particles (FeCrNi) cultured in vitro. This study demonstrates the induction and prominent expression of CD86 on almost all macrophage subsets at the bone/implant interface, including fused forms and large multinucleated giant cells (MNGC). In vitro analysis also indicated phagocytosis of metal particles by differentiated U937 caused significant induction of both CD80 and CD86 (p < 0.01), although the expression of CD86 dominated following prolonged exposure. The data presented highlights that CD86 is the predominant costimulatory molecule ligating to the complementary CD28 molecule at the inflammatory lesion of the interface. We propose that the intracellular presence of indigestible implant material, in addition to elevated costimulatory molecule expression, may promote T-cell inflammatory reactions at sites close to and distant from the orthopedic implant.

34 CFR 636.6 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 636.6 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 654.4 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 636.6 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 636.6 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 654.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 654.4 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 654.4 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 636.6 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

34 CFR 654.4 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (8) 34 CFR part 86 (Drug-Free Schools and Campuses...

Use of Evidence-Based Practices and Resources Among Comprehensive Cancer Control Programs.

PubMed

Steele, C Brooke; Rose, John M; Chovnick, Gary; Townsend, Julie S; Stockmyer, Chrisandra K; Fonseka, Jamila; Richardson, Lisa C

2015-01-01

While efforts to promote use of evidence-based practices (EBPs) for cancer control have increased, questions remain whether this will result in widespread adoption of EBPs (eg, Guide to Community Preventive Services interventions) by comprehensive cancer control (CCC) programs. To examine use of EBPs among CCC programs to develop cancer control plans and select interventions. Conducted Web-based surveys of and telephone interviews with CCC program staff between March and July 2012. CCC programs funded by the Centers for Disease Control and Prevention's National Comprehensive Cancer Control Program (NCCCP). Sixty-one CCC program directors. 1) Use of and knowledge/attitudes about EBPs and related resources and 2) EBP-related technical assistance needs. Seventy-five percent of eligible program directors reported use of EBPs to a moderate or great extent to address program objectives. Benefits of using EBPS included their effectiveness has been proven, they are an efficient use of resources, and they lend credibility to an intervention. Challenges to using EBPs included resource limitations, lack of culturally appropriate interventions, and limited skills adapting EBPs for local use. Most respondents had heard of and used Web sites for The Guide to Community Preventive Services (95% and 91%, respectively) and Cancer Control P.L.A.N.E.T. (98% and 75%, respectively). Training needs included how to adapt an EBP and its materials for cultural appropriateness (state 78%, tribe 86%, territory 80%) and how to maintain the fidelity of an EBP (state 75%, tribe 86%, territory 60%). While awareness, knowledge, and use of EBPs and related resources are high, respondents identified numerous challenges and training needs. The findings from this study may be used to enhance technical assistance provided to NCCCP grantees related to selecting and implementing EBPs.

Use of Evidence-Based Practices and Resources Among Comprehensive Cancer Control Programs

PubMed Central

Steele, C. Brooke; Rose, John M.; Chovnick, Gary; Townsend, Julie S.; Stockmyer, Chrisandra K.; Fonseka, Jamila; Richardson, Lisa C.

2015-01-01

Context While efforts to promote use of evidence-based practices (EBPs) for cancer control have increased, questions remain whether this will result in widespread adoption of EBPs (eg, Guide to Community Preventive Services interventions) by comprehensive cancer control (CCC) programs. Objective To examine use of EBPs among CCC programs to develop cancer control plans and select interventions. Design Conducted Web-based surveys of and telephone interviews with CCC program staff between March and July 2012. Setting CCC programs funded by the Centers for Disease Control and Prevention’s National Comprehensive Cancer Control Program (NCCCP). Participants Sixty-one CCC program directors. Main Outcome Measures 1) Use of and knowledge/attitudes about EBPs and related resources and 2) EBP-related technical assistance needs. Results Seventy-five percent of eligible program directors reported use of EBPs to a moderate or great extent to address program objectives. Benefits of using EBPS included their effectiveness has been proven, they are an efficient use of resources, and they lend credibility to an intervention. Challenges to using EBPs included resource limitations, lack of culturally appropriate interventions, and limited skills adapting EBPs for local use. Most respondents had heard of and used Web sites for The Guide to Community Preventive Services (95% and 91%, respectively) and Cancer Control P.L.A.N.E.T. (98% and 75%, respectively). Training needs included how to adapt an EBP and its materials for cultural appropriateness (state 78%, tribe 86%, territory 80%) and how to maintain the fidelity of an EBP (state 75%, tribe 86%, territory 60%). Conclusions While awareness, knowledge, and use of EBPs and related resources are high, respondents identified numerous challenges and training needs. The findings from this study may be used to enhance technical assistance provided to NCCCP grantees related to selecting and implementing EBPs. PMID:24402431

Airspace Complexity and its Application in Air Traffic Management

NASA Technical Reports Server (NTRS)

Sridhar, Banavar; Chatterji, Gano; Sheth, Kapil; Edwards, Thomas (Technical Monitor)

1998-01-01

The United States Air Traffic Management (ATM) system provides services to enable safe, orderly and efficient aircraft operations within the airspace over the continental United States and over large portions of the Pacific and Atlantic Oceans, and the Gulf of Mexico. It consists of two components, Air Traffic Control (ATC) and Traffic Flow Management (TFM). The ATC function ensures that the aircraft within the airspace are separated at all times while the TFM function organizes the aircraft into a flow pattern to ensure their safe and efficient movement. In order to accomplish the ATC and TFM functions, the airspace over United States is organized into 22 Air Route Traffic Control Centers (ARTCCs). The Center airspace is stratified into low-altitude, high-altitude and super-high altitude groups of Sectors. Each vertical layer is further partitioned into several horizontal Sectors. A typical ARTCC airspace is partitioned into 20 to 80 Sectors. These Sectors are the basic control units within the ATM system.

A Community Intervention to Decrease Antibiotics Used for Self-Medication Among Latino Adults

PubMed Central

Mainous, Arch G.; Diaz, Vanessa A.; Carnemolla, Mark

2009-01-01

PURPOSE Recent evidence in Latino communities indicates substantial self-medication with antibiotics obtained without a prescription (WORx). We implemented and evaluated a culturally sensitive educational intervention to decrease antibiotic self-medication. METHODS We conducted a community-based intervention with preintervention and postintervention measures in the intervention community (Charleston, South Carolina) as well as a postintervention measure in a control community (Greenville, South Carolina) 200 miles away. The 9-month culturally sensitive intervention included multiple media sources (pamphlets, radio, newspapers). We evaluated the use of antibiotics WORx in the United States, as well as the likelihood of importing antibiotics, by surveying Latino adults in the intervention (n = 250) and in the control community (n = 250). RESULTS Most adults in the intervention community (69%) and the control community (60%) reported some exposure to messages about the inappropriate use of antibiotics, and 25.9% in the intervention community and 8.6% in the control community reported seeing our patient education pamphlets. A substantial proportion of Latino adults in both the intervention (31%) and control communities (20%) have obtained antibiotics WORx in the United States. In multivariate analyses, exposure to an educational message was not a significant predictor of having acquired antibiotics WORx in the United States in past 12 months. The primary predictor of respondents’ having acquired antibiotics WORx in the United States was whether they had bought antibiotics WORx outside the United States. CONCLUSIONS Novel approaches are needed to decrease the use of antibiotics WORx in Latino communities, as focusing only on education may not be sufficient to change behaviors common in their home countries. PMID:19901311

Customer Service Analysis of Tactical Air Command Base Level Supply Support

DTIC Science & Technology

1990-09-01

function. A large number of respondents described customer service as an activity such as order processing , handling of complaints, or troubleshooting...thru 14 General Service .69 19 thru 28 Demeanor of Supply .86 Representatives 29 thru 36 Order Processing .82 37 thru 40 Order Cycle Time .84 41 thru...Representatives 23 thru 30 Order Processing .83 31 thru 34 Order Cycle Time .75 35 thru 39 Item Availability .80 40 thru 45 Responsiveness .86 Univariate

JPRS Report, East Asia Southeast Asia People’s Republic of Kampuchea: Biographic Information on Officials

DTIC Science & Technology

1989-03-30

Revolutionary Committee; see KIM SANGKUM; candidate in May 81 general elections; secretary of Kompong Som municipal provisional party committee (SPK... UNG SAMI (Mar 87); deputy defense minister & chief of KPRAF General Staff replacing KOY BUNTHA (Dec 86); member of KPRP CC, deputy defense...Phnom Penh Military Command (SPK Mar 86); see VEN KAROM. KIM HAK Chairman of Phnom Penh District People’s Revolutionary Committee (Oct 80); see MAU

Can a Canine Companion Modify Cardiac Autonomic Reactivity and Tone in PTSD

DTIC Science & Technology

2018-01-01

intensive and non -dog completers due to extension of the recruitment period and lower than expected withdrawals. To summarize across published and...the design and 86% of the non -intensive limb. Ongoing efforts to remediate recruitment into the intensive limb are detailed below. 5...n) SOW target to date SOW target final Total Enrolled 153 204 (75%) 242 (63%) Dog (intensive) 49 66 (74%) 80 (61%) Non -dog 104 121 (86%) 160

Corrosion-Inhibiting Coating Composition.

DTIC Science & Technology

1990-03-01

acrylic polymers were designed for compatibility with the alkyd resins and are useful therefore in preparing coatings of improved hardness...Hydrocarbon solvents 10 to 50 Componentam PatIbyWih Acrylic resin (B-67) 17.3 Silicone resin (SR-80M) 17.3 Silicone- alkyd resin 8.6 (V(ARKYD 385-50E...aichol e.6 VM&P Naphtha 17.1 Example II I ComponentPatbyWgh Acrylic resin 17.3 15 Silicone resin 17.3 Silicone- alkyd resin 8.6 Alkyl

Reverse trends of TEX86 temperature in coastal areas of the East China Sea over the last 100 years: implication for global warming and regional circulation

NASA Astrophysics Data System (ADS)

Cao, Y.; Xing, L.; Zhang, T.

2017-12-01

To reconstruct and compare the SST changes in different regions of the ECS over the last 100 years, in this study, we analyzed iGDGTs compounds and TEX86 index in two sediment cores (DH5-1 and DH6-2) from the inner shelf of the East China Sea (ECS). GDGT-0 and GDGT-5 in the two cores account for 80% of iGDGTs, significantly more abundant than the other iGDGTs compounds. It is also found that iGDGTs are mainly derived from marine Thaumarchaeota. TEXH86 temperatures varied from 17 °C to 22 °C (average 19.4 °C), showing a gradual increase in Core DH5-1 near the Changjiang River Estuary, corresponding to global warming and temperature rise in the ECS over the last 100 years. However, in Core DH6-2 further away from the Changjiang River Estuary, TEXH86 temperatures gradually decreased over the last 80 years with a range of 15.3 °C-18.3 °C, which is attributed to the strengthened near-shore Kuroshio Branch Current transporting more subsurface cold water to the ECS coastal area. In future, more sites should be investigated to confirm the range of the coastal area where the decrease in SST is caused by upwelling subsurface water.

IgA and neutralizing antibodies to influenza a virus in human milk: a randomized trial of antenatal influenza immunization.

PubMed

Schlaudecker, Elizabeth P; Steinhoff, Mark C; Omer, Saad B; McNeal, Monica M; Roy, Eliza; Arifeen, Shams E; Dodd, Caitlin N; Raqib, Rubhana; Breiman, Robert F; Zaman, K

2013-01-01

Antenatal immunization of mothers with influenza vaccine increases serum antibodies and reduces the rates of influenza illness in mothers and their infants. We report the effect of antenatal immunization on the levels of specific anti-influenza IgA levels in human breast milk. (ClinicalTrials.gov identifier NCT00142389; http://clinicaltrials.gov/ct2/show/NCT00142389). The Mother's Gift study was a prospective, blinded, randomized controlled trial that assigned 340 pregnant Bangladeshi mothers to receive either trivalent inactivated influenza vaccine, or 23-valent pneumococcal polysaccharide vaccine during the third trimester. We evaluated breast milk at birth, 6 weeks, 6 months, and 12 months, and serum at 10 weeks and 12 months. Milk and serum specimens from 57 subjects were assayed for specific IgA antibody to influenza A/New Caledonia (H1N1) using an enzyme-linked immunosorbent assay (ELISA) and a virus neutralization assay, and for total IgA using ELISA. Influenza-specific IgA levels in breast milk were significantly higher in influenza vaccinees than in pneumococcal controls for at least 6 months postpartum (p = 0.04). Geometric mean concentrations ranged from 8.0 to 91.1 ELISA units/ml in vaccinees, versus 2.3 to 13.7 ELISA units/mL in controls. Virus neutralization titers in milk were 1.2 to 3 fold greater in vaccinees, and correlated with influenza-specific IgA levels (r = 0.86). Greater exclusivity of breastfeeding in the first 6 months of life significantly decreased the expected number of respiratory illness with fever episodes in infants of influenza-vaccinated mothers (p = 0.0042) but not in infants of pneumococcal-vaccinated mothers (p = 0.4154). The sustained high levels of actively produced anti-influenza IgA in breast milk and the decreased infant episodes of respiratory illness with fever suggest that breastfeeding may provide local mucosal protection for the infant for at least 6 months. Studies are needed to determine the cellular and immunologic mechanisms of breast milk-mediated protection after antepartum immunization. ClinicalTrials.gov NCT00142389.

The Structured Interview and Interviewer Training in the Admissions Process

PubMed Central

Cox, Wendy C.; White-Harris, Carla; Blalock, Susan J.

2007-01-01

Objectives To determine the extent to which the structured interview is used in the PharmD admissions process in US colleges and schools of pharmacy, and the prevalence and content of interviewer training. Methods A survey instrument consisting of 7 questions regarding interviews and interviewer training was sent to 92 colleges and schools of pharmacy in the United States that were accredited or seeking accreditation. Results Sixty survey instruments (65% response rate) were returned. The majority of the schools that responded (80%) used interviews as part of the PharmD admissions process. Of the schools that used an interview as part of the admissions process, 86% provided some type of interviewer training and 13% used a set of predefined questions in admissions interviews. Conclusions Most colleges and schools of pharmacy use some components of the structured interview in the PharmD admissions process; however, training for interviewers varies widely among colleges and schools of pharmacy. PMID:17998980

Oxygen and strontium isotopic studies of basaltic lavas from the Snake River plain, Idaho

USGS Publications Warehouse

Leeman, William P.; Whelan, Joseph F.

1983-01-01

The Snake Creek-Williams Canyon pluton of the southern Snake Range crops out over an area of about 30 km2, about 60 km southeast of Ely, Nev. This Jurassic intrusion displays large and systematic chemical and mineralogical zonation over a horizontal distance of 5 km. Major-element variations compare closely with Dalyls average andesite-dacite-rhyolite over an SiO2 range of 63 to 76 percent. For various reasons it was originally thought that assimilation played a dominant role in development of the Snake Creek-Williams Canyon pluton. However, based on modeling of more recently obtained trace element and isotopic data, we have concluded that the zonation is the result of in-situ fractional crystallization, with little assimilation at the level of crystallization. This report summarizes data available for each of the mineral species present in the zoned intrusion. Special attention has been paid to trends We present oxygen and strontium isotopic data for olivine tholeiites, evolved (that is, differentiated and (or) contaminated) lavas, rhyolites, and crustal- derived xenoliths from the Snake River Plain. These data show that the olivine tholeiites are fairly uniform in d80 (5.1 to 6.2) and 87Sr/86Sr (0.7056 to 0.7076) and reveal no correlation between these ratios. The tholeiites are considered representative of mantle-derived magmas that have not interacted significantly with crustal material or meteoric water. The evolved lavas display a wider range in d 80 (5.6 to 7.6) and 87Sr/86Sr (0.708 to 0.717) with positive correlations between these ratios in some suites but not in others. Crustal xenoliths have high and variable 8?Sr/86Sr (0.715 to 0.830) and d80 values that vary widely (6.7 to 9.2) and are a few permil greater than d80 values of the Snake River basalts. Thus, isotopic data for the evolved lavas are permissive of small degrees of contamination by crustal rocks similar to the most d80-depleted xenoliths. The d80 enrichments in some evolved lavas also are consistent with crystal fractionation processes and do not necessarily require bulk interaction with crustal rocks. Enrichment in d80 but not in 87Sr/86Sr in one suite of evolved lavas suggests that crustal contamination may not be essential to the petrogenesis of those lavas. Other suites of evolved lavas display large variations in 87Sr/86Sr that reflect at least some selective contamination with 87St. Bulk solid/liquid oxygen-isotope fractionation factors (a's) calculated for the evolved lavas from Craters of the Moon National Monument are comparatively large. These a's are dependent upon the nature and proportions of phases removed by crystal fractionation; basaltic lava a's differ from latitic lava a?s in accordance with different phenocryst assemblages in these rocks. Snake River Plain rhyolites are isotopically distinct from both the analyzed crustal xenoliths and olivine tholeiites. Their origin remains poorly understood, but crustal or sub-crustal sources may be viable. In the first case, they must be derived by anatexis of material distinct from the analyzed crustal xenoliths. In the second case, they must be derived from material unlike the source for tholeiites. No cogenetic relation with the tholeiites seems likely on the basis of available data. that might relate to the variation in the chemical petrology of the pluton.

Macular pigment levels do not influence C-Quant retinal straylight estimates in young Caucasians.

PubMed

Beirne, Raymond O

2014-03-01

Individuals with higher than normal levels of macular pigment optical density (MPOD) are less affected by disability glare, when using glare source lights with a strong short-wavelength component. The aim of this study was to investigate whether estimates of retinal straylight from the Oculus Cataract Quantifier (C-Quant), which corresponds to disability glare, are associated with estimates of macular pigment levels in young Caucasian eyes. Thirty-seven Caucasian individuals (aged 19 to 40 years) with good visual acuity, free from ocular disease and with clear ocular media participated. Macular pigment optical density was measured at 0.5 degrees eccentricity from the foveal centre using a heterochromatic flicker photometry-based densitometer instrument from MacularMetrics. Retinal straylight was estimated using the C-Quant, a commercially available device, which uses a psychophysical compensation comparison method. Mean MPOD was 0.39 ± 0.18 log units (range zero to 0.80) and was not significantly related to age (r = -0.07, p = 0.66). Mean straylight parameter (s) was 1.01 ± 0.09 log units (range 0.86 to 1.21) and was not significantly related to age (r = -0.03, p = 0.86). Although there was a small tendency for straylight measurements to be reduced in individuals with higher levels of MPOD, there was no statistically significant relationship between retinal straylight and MPOD (r = -0.17, p = 0.30). Ocular straylight, estimated by the Oculus C-Quant, is little influenced by macular pigment optical density. As the C-Quant uses balanced (white) lights, it is suggested that the previous findings on the effect of macular pigment critically depend on the use of blue-dominant glare sources. © 2013 The Author. Clinical and Experimental Optometry © 2013 Optometrists Association Australia.

34 CFR 381.4 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The...

34 CFR 380.8 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 380. (c...

34 CFR 381.4 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The...

34 CFR 377.4 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The following regulations in 34 CFR part 369...

34 CFR 377.4 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The following regulations in 34 CFR part 369...

34 CFR 380.8 - What regulations apply?

Code of Federal Regulations, 2012 CFR

2012-07-01

... of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 380. (c...

34 CFR 377.4 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The following regulations in 34 CFR part 369...

34 CFR 380.8 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 380. (c...

34 CFR 381.4 - What regulations apply?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The...

34 CFR 381.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The...

34 CFR 381.4 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and Cooperative Agreements to... Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The...

34 CFR 377.4 - What regulations apply?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The following regulations in 34 CFR part 369...

34 CFR 377.4 - What regulations apply?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The following regulations in 34 CFR part 369...

34 CFR 380.8 - What regulations apply?

Code of Federal Regulations, 2013 CFR

2013-07-01

... of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 380. (c...

40 CFR 86.428-80 - Maintenance, scheduled; test vehicles.

Code of Federal Regulations, 2011 CFR

2011-07-01

... necessary. For example, piston and cylinder replacement caused by piston seizure which results in the vehicle being inoperative; or in the case of two-stroke engines, decarbonization, the need for which is...

40 CFR 86.428-80 - Maintenance, scheduled; test vehicles.

Code of Federal Regulations, 2012 CFR

2012-07-01

... necessary. For example, piston and cylinder replacement caused by piston seizure which results in the vehicle being inoperative; or in the case of two-stroke engines, decarbonization, the need for which is...

40 CFR 86.428-80 - Maintenance, scheduled; test vehicles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... necessary. For example, piston and cylinder replacement caused by piston seizure which results in the vehicle being inoperative; or in the case of two-stroke engines, decarbonization, the need for which is...

40 CFR 86.428-80 - Maintenance, scheduled; test vehicles.

Code of Federal Regulations, 2014 CFR

2014-07-01

... necessary. For example, piston and cylinder replacement caused by piston seizure which results in the vehicle being inoperative; or in the case of two-stroke engines, decarbonization, the need for which is...

Development of a prototype chest digital tomosynthesis (CDT) R/F system with fast image reconstruction using graphics processing unit (GPU) programming

NASA Astrophysics Data System (ADS)

Choi, Sunghoon; Lee, Seungwan; Lee, Haenghwa; Lee, Donghoon; Choi, Seungyeon; Shin, Jungwook; Seo, Chang-Woo; Kim, Hee-Joung

2017-03-01

Digital tomosynthesis offers the advantage of low radiation doses compared to conventional computed tomography (CT) by utilizing small numbers of projections ( 80) acquired over a limited angular range. It produces 3D volumetric data, although there are artifacts due to incomplete sampling. Based upon these characteristics, we developed a prototype digital tomosynthesis R/F system for applications in chest imaging. Our prototype chest digital tomosynthesis (CDT) R/F system contains an X-ray tube with high power R/F pulse generator, flat-panel detector, R/F table, electromechanical radiographic subsystems including a precise motor controller, and a reconstruction server. For image reconstruction, users select between analytic and iterative reconstruction methods. Our reconstructed images of Catphan700 and LUNGMAN phantoms clearly and rapidly described the internal structures of phantoms using graphics processing unit (GPU) programming. Contrast-to-noise ratio (CNR) values of the CTP682 module of Catphan700 were higher in images using a simultaneous algebraic reconstruction technique (SART) than in those using filtered back-projection (FBP) for all materials by factors of 2.60, 3.78, 5.50, 2.30, 3.70, and 2.52 for air, lung foam, low density polyethylene (LDPE), Delrin® (acetal homopolymer resin), bone 50% (hydroxyapatite), and Teflon, respectively. Total elapsed times for producing 3D volume were 2.92 s and 86.29 s on average for FBP and SART (20 iterations), respectively. The times required for reconstruction were clinically feasible. Moreover, the total radiation dose from our system (5.68 mGy) was lower than that of conventional chest CT scan. Consequently, our prototype tomosynthesis R/F system represents an important advance in digital tomosynthesis applications.

Anal sphincter trauma and anal incontinence in urogynecological patients.

PubMed

Guzmán Rojas, R A; Kamisan Atan, I; Shek, K L; Dietz, H P

2015-09-01

To determine the prevalence of evidence of residual obstetric anal sphincter injury, to evaluate its association with anal incontinence (AI) and to establish minimal diagnostic criteria for significant (residual) external anal sphincter (EAS) trauma. This was a retrospective analysis of ultrasound volume datasets of 501 patients attending a tertiary urogynecological unit. All patients underwent a standardized interview including determination of St Mark's score for those presenting with AI. Tomographic ultrasound imaging (TUI) was used to evaluate the EAS and the internal anal sphincter (IAS). Among a total of 501 women, significant EAS and IAS defects were found in 88 and 59, respectively, and AI was reported by 69 (14%). Optimal prediction of AI was achieved using a model that included four abnormal slices of the EAS on TUI. IAS defects were found to be less likely to be associated with AI. In a multivariable model controlling for age and IAS trauma, the presence of at least four abnormal slices gave an 18-fold (95% CI, 9-36; P < 0.0001) increase in the likelihood of AI, compared with those with fewer than four abnormal slices. Using receiver-operating characteristics curve statistics, this model yielded an area under the curve of 0.86 (95% CI, 0.80-0.92). Both AI and significant EAS trauma are common in patients attending urogynecological units, and are strongly associated with each other. Abnormalities of the IAS seem to be less important in predicting AI. Our data support the practice of using, as a minimal criterion, defects present in four of the six slices on TUI for the diagnosis of significant EAS trauma. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.

Growth performance and immunological and antioxidant status of Chinese shrimp, Fennerpenaeus chinensis reared in bio-floc culture system using probiotics.

PubMed

Kim, Min-Su; Min, EunYoung; Kim, Jun-Hwan; Koo, Ja-Keun; Kang, Ju-Chan

2015-11-01

Chinese shrimp Fennerpenaeus chinensis (mean length 1.86 ± 0.15 cm, and weight 137.4 ± 12.7 mg) were reared in the different concentrations of bio-floc (control, 60, 80, 100, 120, and 140%) for 90 days. The growth rate was significantly increased over 100% bio-floc concentrations. In the immunological parameters, the gene expression of proPO and lysozyme was considerably increased over 120% bio-floc concentrations. The gene expression of SP was notably elevated at 140% bio-floc concentration. In the antioxidant enzymes, the activity of SOD was considerably decreased over 80% bio-floc concentrations. A notable decline in the activity of CAT was observed over 120% bio-floc concentrations. The results indicate that rearing of Chinese shrimp in bio-floc system can induce the increase of growth performance, enhancement of immune responses, and reduction of oxidative stress. Copyright © 2015 Elsevier Ltd. All rights reserved.

Effects of mixed-method cooling on recovery of medium-fast bowling performance in hot conditions on consecutive days.

PubMed

Minett, Geoffrey M; Duffield, Rob; Kellett, Aaron; Portus, Marc

2012-01-01

This investigation examined physiological and performance effects of cooling on recovery of medium-fast bowlers in the heat. Eight, medium-fast bowlers completed two randomised trials, involving two sessions completed on consecutive days (Session 1: 10-overs and Session 2: 4-overs) in 31 ± 3°C and 55 ± 17% relative humidity. Recovery interventions were administered for 20 min (mixed-method cooling vs. control) after Session 1. Measures included bowling performance (ball speed, accuracy, run-up speeds), physical demands (global positioning system, counter-movement jump), physiological (heart rate, core temperature, skin temperature, sweat loss), biochemical (creatine kinase, C-reactive protein) and perceptual variables (perceived exertion, thermal sensation, muscle soreness). Mean ball speed was higher after cooling in Session 2 (118.9 ± 8.1 vs. 115.5 ± 8.6 km · h⁻¹; P = 0.001; d = 0.67), reducing declines in ball speed between sessions (0.24 vs. -3.18 km · h⁻¹; P = 0.03; d = 1.80). Large effects indicated higher accuracy in Session 2 after cooling (46.0 ± 11.2 vs. 39.4 ± 8.6 arbitrary units [AU]; P = 0.13; d = 0.93) without affecting total run-up speed (19.0 ± 3.1 vs. 19.0 ± 2.5 km · h⁻¹; P = 0.97; d = 0.01). Cooling reduced core temperature, skin temperature and thermal sensation throughout the intervention (P = 0.001-0.05; d = 1.31-5.78) and attenuated creatine kinase (P = 0.04; d = 0.56) and muscle soreness at 24-h (P = 0.03; d = 2.05). Accordingly, mixed-method cooling can reduce thermal strain after a 10-over spell and improve markers of muscular damage and discomfort alongside maintained medium-fast bowling performance on consecutive days in hot conditions.

ATCA digital controller hardware for vertical stabilization of plasmas in tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batista, A. J. N.; Sousa, J.; Varandas, C. A. F.

2006-10-15

The efficient vertical stabilization (VS) of plasmas in tokamaks requires a fast reaction of the VS controller, for example, after detection of edge localized modes (ELM). For controlling the effects of very large ELMs a new digital control hardware, based on the Advanced Telecommunications Computing Architecture trade mark sign (ATCA), is being developed aiming to reduce the VS digital control loop cycle (down to an optimal value of 10 {mu}s) and improve the algorithm performance. The system has 1 ATCA trade mark sign processor module and up to 12 ATCA trade mark sign control modules, each one with 32 analogmore » input channels (12 bit resolution), 4 analog output channels (12 bit resolution), and 8 digital input/output channels. The Aurora trade mark sign and PCI Express trade mark sign communication protocols will be used for data transport, between modules, with expected latencies below 2 {mu}s. Control algorithms are implemented on a ix86 based processor with 6 Gflops and on field programmable gate arrays with 80 GMACS, interconnected by serial gigabit links in a full mesh topology.« less

[Children's medically complex diseases unit. A model required in all our hospitals].

PubMed

Climent Alcalá, Francisco José; García Fernández de Villalta, Marta; Escosa García, Luis; Rodríguez Alonso, Aroa; Albajara Velasco, Luis Adolfo

2018-01-01

The increase in survival of children with severe diseases has led to the rise of children with chronic diseases, sometimes with lifelong disabilities. In 2008, a unit for the specific care of medically complex children (MCC) was created in Hospital La Paz. To describe the work and care activities of this Unit. Patients and methods An analysis was performed on all discharge reports of the Unit between January 2014 and July 2016. The MCC Unit has 6 beds and daily outpatient clinic. A total of 1,027 patients have been treated since the creation of the unit, with 243 from 2014. The median age was 24.2 months (IQ: 10.21-84.25). The large majority (92.59%) have multiple diseases, the most frequent chronic conditions observed were neurological (76.95%), gastrointestinal (63.78%), and respiratory diseases (61.72%). More than two-thirds (69.54%) of MCC are dependent on technology, 53.49% on respiratory support, and 35.80% on nutritional support. Hospital admission rates have increased annually. There have been 403 admissions since 2014, of which 8.93% were re-admissions within 30 days of hospital discharge. The median stay during 2014-2016 was 6 days (IQ: 3-14). The occupancy rate has been above 100% for this period. Currently, 210 patients remain on follow-up (86.42%), and 11 children (4.53%) were discharged to their referral hospitals. The mortality rate is 9.05% (22 deaths). The main condition of these 22 patients was neurological (9 patients). Infectious diseases were the leading cause of death. MCC should be treated in specialized units in tertiary or high-level hospitals. Copyright © 2016 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

40 CFR 1065.710 - Gasoline.

Code of Federal Regulations, 2010 CFR

2010-07-01

...: Initial boiling point °C 24-35 2 24-36 10% point °C 49-57 37-48 ASTM D86-07a. 50% point °C 93-110 82-101... m3/m3 Maximum, 0.10 Maximum, 0.175 ASTM D1319-03. Aromatics Maximum, 0.35 Maximum, 0.304 Saturates.../liter Maximum, 0.0013 Maximum, 0.005 ASTM D3231-07. Total sulfur mg/kg Maximum, 80 Maximum, 80 ASTM...

Theory Z Management. Can It Be Used Effectively in the Air Force?

DTIC Science & Technology

1983-04-11

performance will be recognized by promotion in the long run. (31;86, 103) Control Systems Theory Z suggests the use of a balanced implicit and explicit... worklife that was popular in the early 1970’s. Finally, the implementation of Theory Z principles would, he feels, work against the competitive advantages...Japanese management for use in the United States. Several American companies are now using Theory Z, and all seem to have prospered. On balance , critics

USSR Report, Space

DTIC Science & Technology

1986-11-12

a correction of its trajectory of movement has been executed using the engine unit of the cargo ship . On the day...8217 (KRASNAYA ZVEZDA, 7 Jun 86) 12 - a ’Mariya,’ ’Sport’ Experiments Performed (IZVESTIYA, 11 Jun 86) 13 Kizim and Solovyev Pass Three Month Mark in...Communication Equipment for Shipping ( A . Knop; IZVESTIYA, 19 Jul 86) 168 - k - ’Intersputnik* Ground Station Commissioned in Nicaragua

50 CFR 86.114 - Do I need to conduct a survey if I already have a plan for installing tie-up facilities?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Do I need to conduct a survey if I already have a plan for installing tie-up facilities? 86.114 Section 86.114 Wildlife and Fisheries UNITED... SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM How States Will Complete...

Effect of physico-chemical treatments on ripening behavior and post-harvest quality of Amrapali mango (Mangifera indica L.) during storage.

PubMed

Singh, Pankaj; Singh, Manoj Kumar; Kumar, Vipin; Kumar, Mukesh; Malik, Sunil

2012-03-01

An experiment was done to assess the effect of various physico-chemical treatments on ripening behavior and post harvest quality of mango cv. Amrapali. The experiment was planned under completely randomized design (CRD) with three replications. The treatment units was five fruits per replication. Total 14 treatments were applied. Out of these, ethrel 750 ppm treated fruits showed better results in respect of specific gravity (0.88), moisture loss (8.45%), decay (2.5%), total soluble solids (TSS, 20.7 degrees brix), sugar content (14.39%) and acidity content (0.32) followed by ethrel 500 ppm; specific gravity (0.90), moisture loss (8.82%), decay (3.5%), TSS (20.7 degrees brix), sugar content (13.99%) and acidity content (0.36%). The pedicellate fruits and ethrel+bavistin (750+1000 ppm) were also found to be significantly superior over control in respect of specific gravity (0.88 and 0.86), moisture loss (9.10 and 9.33%), decay (4.0 and 5.33%), TSS (20.1 and 20.4 degrees brix), sugar content (12.70 and 12.80%) and acidity content (0.42 and 0.38%), respectively. Based on results of this study, it can be concluded that ethrel 750 ppm was found to be the most suitable treatment in improving physico-chemical traits i.e. ripening, storage, quality and shelf-life for commercial purpose in mango.

Altered erythrocyte Na-K pump in anorectic patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasquali, R.; Strocchi, E.; Malini, P.

1985-07-01

The status of the erythrocyte sodium pump was evaluated in a group of patients suffering from anorexia nervosa and a group of healthy female control subjects. Anorectic patients showed significantly higher mean values of digoxin-binding sites/cell (ie, the number of Na-K-ATPase units) with respect to control subjects while no differences were found in the specific /sup 86/Rb uptake (which reflects the Na-K-ATPase activity) between the two groups. A significant correlation was found between relative weight and the number of Na-K-ATPase pump units (r = -0.66; P less than 0.0001). Anorectic patients showed lower serum T3 concentrations (71.3 +/- 53 ng/dL)more » with respect to control subjects (100.8 +/- 4.7 ng/dL; P less than 0.0005) and a significant negative correlation between T3 levels and the number of pump units (r = -0.52; P less than 0.003) was found. This study therefore shows that the erythrocyte Na-K pump may be altered in several anorectic patients. The authors suggest that this feature could be interrelated with the degree of underweight and/or malnutrition.« less

[High-grade pressure sores in frail older high-risk persons. A retrospective postmortem case-control-study].

PubMed

Von Renteln-Kruse, W; Krause, T; Anders, J; Kühl, M; Heinemann, A; Püschel, K

2004-04-01

Some old persons at risk do develop, but others, at comparable risk, do not develop high-grade pressure sores. To evaluate potentially different risk factors, we performed a post mortem case-control study in old persons who developed high-grade pressure sores within six months until 14 days before death. Consecutive cases with pressure sores grade >/=3 and potential controls at comparably high risk for pressure sores were examined before cremation. After written informed consent had been obtained by the next relatives, all available nursing and medical records of the deceased were thoroughly evaluated. Cases and controls were matched according to age, gender, immobility, and cachexia.A total of 100 cases with 71 pressure sores grade 3 and 29 pressure sores grade 4 were compared to 100 controls with 27 pressure sores grade

Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial.

PubMed

Pourdast, Alieh; Sanaei, Maryam; Jafari, Sirous; Mohammadi, Mostafa; Khalili, Hossein; Shafiee, Gita; Ahadi, Zeinab; Rostami, Mahsa; Alizad, Saba; Heshmat, Ramin; Mohraz, Minoo

2017-01-01

Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily. Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P<0.001) and a significant increase in GCS value (14.46±0.88) compared to the control group (12.86±1.78) (P<0.001). Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07±34.80, control group: 51.75±42.10, P=0.98) and CRP (Septimeb group: 48.86±23.21, control group: 49.93±36.22, P=0.92) decreased, but did not show a significant reduction. Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients' mortality rates.

Effect of SeptimebTM as a new natural extract on severe sepsis: A randomized clinical trial

PubMed Central

Pourdast, Alieh; Sanaei, Maryam; Jafari, Sirous; Mohammadi, Mostafa; Khalili, Hossein; Shafiee, Gita; Ahadi, Zeinab; Rostami, Mahsa; Alizad, Saba; Heshmat, Ramin; Mohraz, Minoo

2017-01-01

Background: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. Methods: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily. Results: Treatment with Septimeb showed a significant decrease in SOFA value (1.54±0.83) compared to the control group (2.39±0.88) (P<0.001) and a significant increase in GCS value (14.46±0.88) compared to the control group (12.86±1.78) (P<0.001). Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07±34.80, control group: 51.75±42.10, P=0.98) and CRP (Septimeb group: 48.86±23.21, control group: 49.93±36.22, P=0.92) decreased, but did not show a significant reduction. Conclusion: Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients’ mortality rates. PMID:28503281

Lifelink: 3G-based mobile telemedicine system.

PubMed

Alis, Christian; del Rosario, Carlos; Buenaobra, Bernardino; Mar Blanca, Carlo

2009-04-01

Current wired telemedicine systems encounter difficulties when implemented in archipelagic developing countries because of the high cost of fixed infrastructure. In this research, we devised Lifelink, a mobile real-time telemonitoring and diagnostic facility to command and control remote medical devices through mobile phones. The whole process is phone-based, effectively freeing offsite medical specialists from stationary monitoring consoles and endowing the system with the potential to increase the number participating consultants. The electrocardiogram (ECG) readings are analyzed using a detrended fluctuation technique and classified into pathological cases using an unassisted K-means clustering algorithm. We analyzed 30 batches of 2-hour ECG signals taken from cardiac patients (20 males, 10 females, mean age 46.7 years) with pre-diagnosed pathologies. The method successfully categorized the 30 subjects without user intervention into the following cases: normal (at 86.7% accuracy), congestive heart failure (86.7%), and atrial fibrillation (80.0%). The synergy of mobile monitoring and fluctuation analysis presents a powerful platform to reach remote, underserved communities with poor or nonexistent wired communication structures. It is likely to be essential in the development of new mobile diagnostic and prognostic measures.

34 CFR 369.3 - What regulations apply to these programs?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Service Program for American Indians with Disabilities. (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 369. (c...

34 CFR 385.3 - What regulations apply to these programs?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 385. (c) The...

34 CFR 385.3 - What regulations apply to these programs?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 385. (c) The...

34 CFR 369.3 - What regulations apply to these programs?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Service Program for American Indians with Disabilities. (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 369. (c...

34 CFR 369.3 - What regulations apply to these programs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Service Program for American Indians with Disabilities. (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 369. (c...

34 CFR 369.3 - What regulations apply to these programs?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Service Program for American Indians with Disabilities. (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 369. (c...

34 CFR 385.3 - What regulations apply to these programs?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 385. (c) The...

34 CFR 385.3 - What regulations apply to these programs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 385. (c) The...

Japanese Resource Dependence.

DTIC Science & Technology

1982-03-01

56% 78% 86% Coal 36 68 80 Crude Oil 98 99 99 Natural Gas -- 78 78 Iron Ore 92 98 98 Copper 86 93 94 Lead 55 64 79 Zinc 36 55 79 Tin 99 98 98 Aluminum...represented by energy resources (oil, gas , coal): The availabilty of adequate energy supplies is of great significance to the minerals and metals production...liquefied natural/petroleum gas , natural gas , and uranium. To meet the country’s energy needs, virtually all forms of mineral fuels were imported to

Operation Plan I-45 ICEBERG

DTIC Science & Technology

1945-02-01

8217COmIIAND OF MAJOR- GENERAL del VALLE: R. O, BARE, Col, USMC, ·C of S. ANNEXES: ABLE - Distribution B1iKER - Intelligence CHARLIE - Naval Gunfire Support Plan...3. ABLE Annex BAKER to Opn Plan 1-45, 1st MarDiv-(Rein) INTELLIGENCE 00015 1st Mar Div (Rein). 1990-5-80 In The Field 475/355 . 1100, 1OFeb, 1945. AP...distributed. (c) JANIS No. 86, August, 1944; JANIS No. 86 (Change 1), October 1944. (d) Engineer Intelligence Information of OKINAWA SHIMA prepared by Eng

United States Air Force Summer Faculty Research Program (1984). Program Management Report. Volume 3

DTIC Science & Technology

1984-12-01

Database Design 蕄 Raman Spectroscopy of Dr. Boake L. Plessy Glycosaminoglycans from -* Bovine Cornea 117 Study of Control Mixer Concept Dr. Kuldip S...simultaneously in polarized and non -polarized controls were repeated three times at 260-64, 368-70, 604-8-13, 735-7-40, 1277-80, 1760, 1775, and 1820 or four...times at S240-2-4, 1020 and 1874-8-90. Pooling replicates from the non -polarized components, six controls and two cAMP treatments, events repeating

Cellular miR-2909 RNomics governs the genes that ensure immune checkpoint regulation.

PubMed

Kaul, Deepak; Malik, Deepti; Wani, Sameena

2018-06-20

Cross-talk between coding RNAs and regulatory non-coding microRNAs, within human genome, has provided compelling evidence for the existence of flexible checkpoint control of T-Cell activation. The present study attempts to demonstrate that the interplay between miR-2909 and its effector KLF4 gene has the inherent capacity to regulate genes coding for CTLA4, CD28, CD40, CD134, PDL1, CD80, CD86, IL-6 and IL-10 within normal human peripheral blood mononuclear cells (PBMCs). Based upon these findings, we propose a pathway that links miR-2909 RNomics with the genes coding for immune checkpoint regulators required for the maintenance of immune homeostasis.

Prevalence of abdominal obesity among Chinese adults in 2011.

PubMed

Du, Pei; Wang, Hui-Jun; Zhang, Bing; Qi, Su-Fen; Mi, Ying-Jun; Liu, Dian-Wu; Tian, Qing-Bao

2017-06-01

The prevalence of abdominal obesity is increasing dramatically worldwide. This study aimed to estimate the current prevalence of abdominal obesity from the 2011 China Health and Nutrition Survey (CHNS) and compare the data with other countries. Waist circumference (WC) of 12,326 Chinese adults (aged 20 years or older) from the 2011 CHNS were analyzed by age group and region. Abdominal obesity was defined as a WC ≥90 cm for men and WC ≥80 cm for women based on World Health Organization (WHO) recommendations for Asians. In 2011, the age-adjusted mean WC was 85.9 cm (95% confidence interval [CI], 85.6-86.2 cm) for men and 80.7 cm (95% CI, 80.4-80.9 cm) for women. Based on the WHO recommendations, the age-adjusted prevalence of abdominal obesity was 44.0% (95% CI, 43.1%-44.8%) overall, 35.3% (95% CI, 34.1%-36.6%) in men, and 51.7% (95% CI, 50.5%-52.9%) in women. Moreover, the age-adjusted prevalence was 44.0% (95% CI, 42.7%-45.2%) in rural populations, 42.5% (95% CI, 40.7%-44.2%) in urban populations, and 45.2% (95% CI, 43.5%-46.9%) in megacity populations. The prevalence in China (35.3% for men and 51.7% for women) was lower than in Japan (50.8% for men) and the United States (43.5% for men and 64.7% for women). Similar results were observed when applying the criteria suggested by the Working Group on Obesity in China. In 2011, the age-adjusted prevalence of abdominal obesity in China was 35.3% in men and 51.7% in women. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Spectroscopy of 204,206,208Rn and the systematic behavior of Z=86 isotopes

NASA Astrophysics Data System (ADS)

Horn, D.; Baktash, C.; Lister, C. J.

1981-11-01

A spectroscopic investigation of the radon isotopes 204,206,208Rn was performed by means of the reactions 192,194,196Pt(16O,4n)204,206,208Rn and 197Au(14N,5n)206Rn with 16O energies between 85 and 110 MeV and 14N energies between 80 and 94 MeV. γ-γ coincidences, pulsed beam yield functions, angular distributions, and pulsed beam isomeric decay rates were measured. The yrast and near-yrast level structure was established to J~15ℏ, and in each of the three nuclei two isomers above the known Jπ=8+ state were observed. The systematic trends for the Z=86 isotopes are compared with the behavior expected in a single particle model, and increased collectivity is found with decreasing neutron number. Analogies are made with the N=86 system. NUCLEAR REACTIONS 192,194,196Pt (16O,4n), E=85-110 MeV; 197Au(14N,5n), E=80-94 MeV. Measured Iγ(E,t), Iγ(θ), γ-γ(t). Deduced level sequences, Jπ, T12, transition rates. Continuous and pulsed beams, enriched targets, Ge(Li) detectors.

Knowing versus doing: education and training needs of staff in a chronic care hospital unit for individuals with dementia.

PubMed

Marx, Katherine A; Stanley, Ian H; Van Haitsma, Kimberly; Moody, Jennifer; Alonzi, Dana; Hansen, Bryan R; Gitlin, Laura N

2014-12-01

Hospital clinical staff routinely confront challenging behaviors in patients with dementia with limited training in prevention and management. The authors of the current article conducted a survey of staff on a chronic care hospital unit concerning knowledge about dementia, perceived educational needs, and the care environment. The overall mean score for a 27-item knowledge scale was 24.08 (SD = 2.61), reflecting high level of disease knowledge. However, staff indicated a need for more information and skills, specifically for managing behaviors nonpharmacologically (92.3%), enhancing patient safety (89.7%), coping with care challenges (84.2%), and involving patients in activities (81.6%). Although most staff (i.e., nurses [80%] and therapists [86.4%]) believed their care contributed a great deal to patient well-being, approximately 75% reported frustration and being overwhelmed by dementia care. Most reported being hit, bitten, or physically hurt by patients (66.7%), as well as disrespected by families (53.8%). Findings suggest that staff have foundational knowledge but lack the "how-to" or hands-on skills necessary to implement nonpharmacological behavioral management approaches and communicate with families. Copyright 2014, SLACK Incorporated.

The Lesbian, Gay, Bisexual, and Transgender Development of Clinical Skills Scale (LGBT-DOCSS): Establishing a New Interdisciplinary Self-Assessment for Health Providers.

PubMed

Bidell, Markus P

2017-01-01

These three studies provide initial evidence for the development, factor structure, reliability, and validity of the Lesbian, Gay, Bisexual, and Transgender Development of Clinical Skills Scale (LGBT-DOCSS), a new interdisciplinary LGBT clinical self-assessment for health and mental health providers. Research participants were voluntarily recruited in the United States and United Kingdom and included trainees, clinicians, and educators from applied psychology, counseling, psychotherapy, and primary care medicine. Study 1 (N = 602) used exploratory and confirmatory factor analytic techniques, revealing an 18-item three-factor structure (Clinical Preparedness, Attitudinal Awareness, and Basic Knowledge). Study 2 established internal consistency for the overall LGBT-DOCSS (α = .86) and for each of the three subscales (Clinical Preparedness = .88, Attitudinal Awareness = .80, and Basic Knowledge = .83) and 2-week test-retest reliability (.87). In study 3 (N = 564), participant criteria (sexual orientation and education level) and four established scales that measured LGBT prejudice, assessment skills, and social desirability were used to support initial content and discriminant validity. Psychometric properties, limitations, and recommendations are discussed.

Engagement as predictors of performance in a single cohort of undergraduate chiropractic students.

PubMed

Rix, Jacqueline; Dewhurst, Philip; Cooke, Caroline; Newell, David

2017-03-01

To investigate the potential association of novel academic and nonacademic factors with chiropractic student academic performance. Students enrolled into year 1 of a chiropractic master's degree (MChiro) at our college were selected for this study. Data collected included demographics, attendance, virtual learning environment use, additional learning needs, previous degree qualifications, and summative marks. Differences between students who had to take an examination more than once (resit) and nonresit students were explored using t test and χ 2 analysis. Relationships between attendance and end-of-year marks were explored using regression analysis. Male students outperformed female students in four of the six units and as the total year average. Students who attended <80% of classes were more likely to have a resit in one or more units (relative risk [ RR] = 2.6; 95% confidence interval [CI], 1.4-4.9). Students who performed poorly (<70%) in the semester 1 unit of a course on human structure and failed the semester 1 practical assessment of a course on clinical management were significantly more likely to have one or more resit assessments in semester 2 units ( RR = 3.5 [95% CI, 2.2-5.7]; RR = 3.2 [95% CI, 2.0-4.9]). Attendance and unit 105 were independent predictors of one or more resits at the end-of-year ( R 2 = 0.86, p < .001). Attendance and first semester summative marks were associated with end-of-year performance. As such, these markers of performance may be used to flag struggling students in the program.

Engagement as predictors of performance in a single cohort of undergraduate chiropractic students

PubMed Central

Rix, Jacqueline; Dewhurst, Philip; Cooke, Caroline; Newell, David

2018-01-01

Objective: To investigate the potential association of novel academic and nonacademic factors with chiropractic student academic performance. Methods: Students enrolled into year 1 of a chiropractic master's degree (MChiro) at our college were selected for this study. Data collected included demographics, attendance, virtual learning environment use, additional learning needs, previous degree qualifications, and summative marks. Differences between students who had to take an examination more than once (resit) and nonresit students were explored using t test and χ2 analysis. Relationships between attendance and end-of-year marks were explored using regression analysis. Results: Male students outperformed female students in four of the six units and as the total year average. Students who attended <80% of classes were more likely to have a resit in one or more units (relative risk [RR] = 2.6; 95% confidence interval [CI], 1.4–4.9). Students who performed poorly (<70%) in the semester 1 unit of a course on human structure and failed the semester 1 practical assessment of a course on clinical management were significantly more likely to have one or more resit assessments in semester 2 units (RR = 3.5 [95% CI, 2.2–5.7]; RR = 3.2 [95% CI, 2.0–4.9]). Attendance and unit 105 were independent predictors of one or more resits at the end-of-year (R2 = 0.86, p < .001). Conclusion: Attendance and first semester summative marks were associated with end-of-year performance. As such, these markers of performance may be used to flag struggling students in the program. PMID:29332429

Multinational Comparison of Prophylactic Antibiotic Use for Eyelid Surgery.

PubMed

Fay, Aaron; Nallasamy, Nambi; Bernardini, Francesco; Wladis, Edward J; Durand, Marlene L; Devoto, Martin H; Meyer, Dale; Hartstein, Morris; Honavar, Santosh; Osaki, Midori H; Osaki, Tammy H; Santiago, Yvette M; Sales-Sanz, Marco; Vadala, Giuseppe; Verity, David

2015-07-01

Antibiotic stewardship is important in controlling resistance, adverse reactions, and cost. The literature regarding antibiotic use for eyelid surgery is lacking. To determine standard care and assess factors influencing antibiotic prescribing practices for eyelid surgery. A survey study was conducted from February 2, 2014, to March 24, 2014. The survey was distributed to 2397 oculoplastic surgeons in private and academic oculoplastic surgery practices in 43 countries. All surgeons were members of ophthalmic plastic and reconstructive surgery societies. Data were analyzed by geographic location. Linear regression was performed to quantify contributions to rates of prescribing postoperative antibiotics for routine eyelid surgical procedures. Rates of prescribing prophylactic intravenous, oral, and topical antibiotics as well as factors that influence surgeons' prescribing practices. A total of 782 responses were received from 2397 surgeons (average response rate, 36.7%; 2.5% margin of error) from 43 countries. Topical antibiotic use was common in all regions (85.2%). Perioperative intravenous antibiotic use was uncommon in all regions (13.5%). Geographic location was the greatest predictor of antibiotic prescribing practices (range, 2.9% in the United Kingdom to 86.7% in India; mean, 24%). Within Europe, Italy had the highest rate of antibiotic prescriptions for eyelid surgery (41.7%) and the United Kingdom had the lowest rate (2.9%.) In South America, Venezuela had the highest rate of antibiotic prescriptions for eyelid surgery (83.3%) and Chile had the lowest rate (0%). The practice locations that were associated with routinely prescribing postoperative oral antibiotics were India (odds ratio [OR], 15.83; 95% CI, 4.85-51.68; P < .001), Venezuela (OR, 13.47; 95% CI, 1.43-127.19; P = .02), and Southeast Asia (OR, 2.80; 95% CI, 1.15-6.84; P = .02). Conversely, practice location in the United Kingdom (OR, 0.048; 95% CI, 0.0063-0.37; P = .004), Australia and New Zealand (OR, 0.15; 95% CI, 0.033-0.67; P = .01), and the United States and Canada (OR, 0.41; 95% CI, 0.23-0.72; P = .002) were associated with decreased rates of postoperative oral antibiotic use. Surgeons' concern for allergic reactions was associated with decreased rates of prescribing antibiotics (OR, 0.34; 95% CI, 0.23-0.49; P < .001), while surgeons' concern for infection was associated with increased rates of prescribing antibiotics (OR 1.80; 95% CI, 1.45-2.23; P < .001). These results from members of ophthalmic plastic and reconstructive surgery societies confirm that antibiotic prescribing practices for routine eyelid surgical procedures vary widely throughout the world. No standard of care has been established that would require the routine use of postoperative prophylactic antibiotics following eyelid surgery.

A PWM Buck Converter With Load-Adaptive Power Transistor Scaling Scheme Using Analog-Digital Hybrid Control for High Energy Efficiency in Implantable Biomedical Systems.

PubMed

Park, Sung-Yun; Cho, Jihyun; Lee, Kyuseok; Yoon, Euisik

2015-12-01

We report a pulse width modulation (PWM) buck converter that is able to achieve a power conversion efficiency (PCE) of > 80% in light loads 100 μA) for implantable biomedical systems. In order to achieve a high PCE for the given light loads, the buck converter adaptively reconfigures the size of power PMOS and NMOS transistors and their gate drivers in accordance with load currents, while operating at a fixed frequency of 1 MHz. The buck converter employs the analog-digital hybrid control scheme for coarse/fine adjustment of power transistors. The coarse digital control generates an approximate duty cycle necessary for driving a given load and selects an appropriate width of power transistors to minimize redundant power dissipation. The fine analog control provides the final tuning of the duty cycle to compensate for the error from the coarse digital control. The mode switching between the analog and digital controls is accomplished by a mode arbiter which estimates the average of duty cycles for the given load condition from limit cycle oscillations (LCO) induced by coarse adjustment. The fabricated buck converter achieved a peak efficiency of 86.3% at 1.4 mA and > 80% efficiency for a wide range of load conditions from 45 μA to 4.1 mA, while generating 1 V output from 2.5-3.3 V supply. The converter occupies 0.375 mm(2) in 0.18 μm CMOS processes and requires two external components: 1.2 μF capacitor and 6.8 μH inductor.

Social perception of morbidity in facial nerve paralysis.

PubMed

Li, Matthew Ka Ki; Niles, Navin; Gore, Sinclair; Ebrahimi, Ardalan; McGuinness, John; Clark, Jonathan Robert

2016-08-01

There are many patient-based and clinician-based scales measuring the severity of facial nerve paralysis and the impact on quality of life, however, the social perception of facial palsy has received little attention. The purpose of this pilot study was to measure the consequences of facial paralysis on selected domains of social perception and compare the social impact of paralysis of the different components. Four patients with typical facial palsies (global, marginal mandibular, zygomatic/buccal, and frontal) and 1 control were photographed. These images were each shown to 100 participants who subsequently rated variables of normality, perceived distress, trustworthiness, intelligence, interaction, symmetry, and disability. Statistical analysis was performed to compare the results among each palsy. Paralyzed faces were considered less normal compared to the control on a scale of 0 to 10 (mean, 8.6; 95% confidence interval [CI] = 8.30-8.86) with global paralysis (mean, 3.4; 95% CI = 3.08-3.80) rated as the most disfiguring, followed by the zygomatic/buccal (mean, 6.0; 95% CI = 5.68-6.37), marginal (mean, 6.5; 95% CI = 6.08-6.86), and then temporal palsies (mean, 6.9; 95% CI = 6.57-7.21). Similar trends were seen when analyzing these palsies for perceived distress, intelligence, and trustworthiness, using a random effects regression model. Our sample suggests that society views paralyzed faces as less normal, less trustworthy, and more distressed. Different components of facial paralysis are worse than others and surgical correction may need to be prioritized in an evidence-based manner with social morbidity in mind. © 2016 Wiley Periodicals, Inc. Head Neck 38:1158-1163, 2016. © 2016 Wiley Periodicals, Inc.

47 CFR 80.503 - Cooperative use of facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... station or marine utility station on shore may install ship radio stations on board United States... verifying that the ship station licensee has the sole right of control of the ship stations, that the vessel operators must use the ship stations subject to the orders and instructions of the coast station or marine...

A High-Order Test for Optimality of Bang-Bang Controls.

DTIC Science & Technology

1983-11-01

Systems * Istituto di Matematica Applicata, Universitl di Padova, ITALY. sponsored by the United States Army under Contract No. DAAG29-80-C-0041...the first order variation at the terminal point of the trajectory lim [x(T,u ) - x(TW)]/E (1.1) Istituto di Matematica Applicata, Universitl di Padova

Medical Surveillance Monthly Report. Volume 19, Number 5

DTIC Science & Technology

2012-05-01

genital herpes ” (ICD-9-CM 054.1 with any fi ft h digit) in any diagnostic position. Incidence rates of MHD were com- pared between three groups of active...cervi- cal cancers and 80 percent of genital warts, was licensed in the United States.2 Consis- tent with the Centers for Disease Control and

34 CFR 460.3 - What regulations apply to the adult education programs?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Education Programs and Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 460. (c) The...

34 CFR 614.3 - What regulations apply to this program?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (10) 34 CFR part 97 (Protection of Human...

34 CFR 460.3 - What regulations apply to the adult education programs?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Education Programs and Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 460. (c) The...

34 CFR 460.3 - What regulations apply to the adult education programs?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Education Programs and Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 460. (c) The...

34 CFR 614.3 - What regulations apply to this program?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (10) 34 CFR part 97 (Protection of Human...

34 CFR 460.3 - What regulations apply to the adult education programs?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Education Programs and Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 460. (c) The...

34 CFR 614.3 - What regulations apply to this program?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Review of Department of Education Programs and Activities). (5) 34 CFR part 80 (Uniform Administrative... (Grants)). (9) 34 CFR part 86 (Drug-Free Schools and Campuses). (10) 34 CFR part 97 (Protection of Human...

34 CFR 460.3 - What regulations apply to the adult education programs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Education Programs and Activities). (6) 34 CFR part 80 (Uniform Administrative Requirements for Grants and...) 34 CFR part 86 (Drug-Free Schools and Campuses). (b) The regulations in this part 460. (c) The...

The pattern of early lung parenchymal and air space injury following acute blood loss.

PubMed

Younger, J G; Taqi, A S; Jost, P F; Till, G O; Johnson, K J; Stern, S A; Hirschl, R B

1998-07-01

Acute lung injury is a frequent clinical occurrence following blood loss and trauma. The nature of this injury remains poorly understood. To examine the relative parenchymal and intra-alveolar distribution of inflammation in a rat model of hemorrhage and resuscitation. Rats were anesthetized and subjected to hemorrhage followed by resuscitation with shed blood and saline. Myeloperoxidase activity of lung homogenates and cytology of bronchoalveolar lavage fluid were used to measure total lung and intra-alveolar neutrophil invasion. Extravasation of i.v.-administered [125I]-albumin was used to determine total lung and alveolar permeability. Permeability results were analyzed using their base-10 logarithmic transformations. 86 animals were studied. Whole-lung myeloperoxidase activity was increased (control = 0.34 +/- 0.16 units, injured = 0.84 +/- 0.43 units, p < 0.01), while there was no difference in intra-alveolar leukocyte counts (injured = 1.85 +/- 1.30 x 10(5)/mL, control = 2.44 +/- 1.75 x 10(5)/mL, p = 0.40), suggesting that the cellular component of the injury was more severe in the intravascular and interstitial spaces. There was a strong trend toward increased permeability in the interstitial compartment, and a significant increase in permeability in the intra-alveolar compartment (whole-lung permeability: control = -0.27 +/- 0.19 units, injured = 0.10 +/- 0.55 units, p = 0.06; alveolar permeability: control = -2.00 +/- 0.47 units, injured = -1.32 +/- 0.49 units, p < 0.01), suggesting that the loss of integrity to macromolecules was not limited to the interstitium. Hemorrhage and resuscitation resulted in an acute lung injury characterized by extravasation of intravascular protein into both the interstitium and the intra-alveolar space. Neutrophil invasion of the lung was demonstrable only in the interstitial compartment.

ENGINEERING DEVELOPMENT UNIT SOLAR SAIL

NASA Image and Video Library

2016-01-13

TIFFANY LOCKETT OVERSEES THE HALF SCALE (36 SQUARE METERS) ENGINEERING DEVELOPMENT UNIT (EDU) SOLAR SAIL DEPLOYMENT DEMONSTRATION IN PREPARATION FOR FULL SCALE EDU (86 SQUARE METERS) DEPLOYMENT IN APRIL, 2016

Wenxin Keli versus Sotalol for Paroxysmal Atrial Fibrillation Caused by Hyperthyroidism: A Prospective, Open Label, and Randomized Study

PubMed Central

Meng, Zhaowei; Tan, Jian; He, Qing; Zhu, Mei; Li, Xue; Zhang, Jianping; Jia, Qiang; Wang, Shen; Zhang, Guizhi; Zheng, Wei

2015-01-01

We aimed to compare effectiveness of Wenxin Keli (WK) and sotalol in assisting sinus rhythm (SR) restoration from paroxysmal atrial fibrillation (PAF) caused by hyperthyroidism, as well as in maintaining SR. We randomly prescribed WK (18 g tid) or sotalol (80 mg bid) to 91 or 89 patients. Since it was not ethical not to give patients antiarrhythmia drugs, no control group was set. Antithyroid drugs were given to 90 patients (45 in WK group, 45 in sotalol group); 131I was given to 90 patients (46 in WK group, 44 in sotalol group). Three months later, SR was obtained in 83/91 or 80/89 cases from WK or sotalol groups (P = 0.762). By another analysis, SR was obtained in 86/90 or 77/90 cases from 131I or ATD groups (P = 0.022). Then, we randomly assigned the successfully SR-reverted patients into three groups: WK, sotalol, and control (no antiarrhythmia drug was given) groups. After twelve-month follow-up, PAF recurrence happened in 1/54, 2/54, and 9/55 cases, respectively. Log-Rank test showed significant higher PAF recurrent rate in control patients than either treatment (P = 0.06). We demonstrated the same efficacies of WK and sotalol to assist SR reversion from hyperthyroidism-caused PAF. We also showed that either drug could maintain SR in such patients. PMID:26074982

Homicide, suicide, and unintentional firearm fatality: comparing the United States with other high-income countries, 2003.

PubMed

Richardson, Erin G; Hemenway, David

2011-01-01

Violent death is a major public health problem in the United States and throughout the world. A cross-sectional analysis of the World Health Organization Mortality Database analyzes homicides and suicides (both disaggregated as firearm related and non-firearm related) and unintentional and undetermined firearm deaths from 23 populous high-income Organization for Economic Co-Operation and Development countries that provided data to the World Health Organization for 2003. The US homicide rates were 6.9 times higher than rates in the other high-income countries, driven by firearm homicide rates that were 19.5 times higher. For 15-year olds to 24-year olds, firearm homicide rates in the United States were 42.7 times higher than in the other countries. For US males, firearm homicide rates were 22.0 times higher, and for US females, firearm homicide rates were 11.4 times higher. The US firearm suicide rates were 5.8 times higher than in the other countries, though overall suicide rates were 30% lower. The US unintentional firearm deaths were 5.2 times higher than in the other countries. Among these 23 countries, 80% of all firearm deaths occurred in the United States, 86% of women killed by firearms were US women, and 87% of all children aged 0 to 14 killed by firearms were US children. The United States has far higher rates of firearm deaths-firearm homicides, firearm suicides, and unintentional firearm deaths compared with other high-income countries. The US overall suicide rate is not out of line with these countries, but the United States is an outlier in terms of our overall homicide rate.

A classification scheme for the morphology of lava flow fields

NASA Technical Reports Server (NTRS)

Wilson, L.; Pinkerton, H.; Head, James W.; Roberts, K. Magee

1993-01-01

Analysis of the processes controlling the advance of lava flows shows that, if no other factors intervene, thermal constraints will act to limit the maximum length of a flow being fed at a given volume or mass effusion rate from a vent. These constraints can be characterized through the Gratz number, which takes on a large value at the vent and decreases down flow. Early application of this principle showed that, despite the many subtleties of modes of heat loss from flows, motion apparently ceases when the Gratz number has decreased to a value close to 300. Recent analyses of flow units from the 1983-86 Pu'u 'O'o eruption of Kilauea and of other, more silicic lava flow units confirm this finding.

Fate and transport of glyphosate and aminomethylphosphonic acid in surface waters of agricultural basins

USGS Publications Warehouse

Coupe, R.H.; Kalkhoff, S.J.; Capel, P.D.; Gregoire, C.

2012-01-01

Background: Glyphosate [N-(phosphonomethyl)glycine] is a herbicide used widely throughout the world in the production of many crops and is heavily used on soybeans, corn and cotton. Glyphosate is used in almost all agricultural areas of the United States, and the agricultural use of glyphosate has increased from less than 10 000 Mg in 1992 to more than 80 000 Mg in 2007. The greatest intensity of glyphosate use is in the midwestern United States, where applications are predominantly to genetically modified corn and soybeans. In spite of the increase in usage across the United States, the characterization of the transport of glyphosate and its degradate aminomethylphosphonic acid (AMPA) on a watershed scale is lacking. Results: Glyphosate and AMPA were frequently detected in the surface waters of four agricultural basins. The frequency and magnitude of detections varied across basins, and the load, as a percentage of use, ranged from 0.009 to 0.86% and could be related to three general characteristics: source strength, rainfall runoff and flow route. Conclusions: Glyphosate use in a watershed results in some occurrence in surface water; however, the watersheds most at risk for the offsite transport of glyphosate are those with high application rates, rainfall that results in overland runoff and a flow route that does not include transport through the soil. ?? 2011 Society of Chemical Industry.

Morphological study of rat skin flaps treated with subcutaneous dimethyl sulfoxide combined with hyperbaric oxygen therapy.

PubMed

Almeida, K G; Oliveira, R J; Dourado, D M; Filho, E A; Fernandes, W S; Souza, A S; Araújo, F H S

2015-12-28

This study investigated the effects of hyperbaric oxygen therapy (HBOT) and dimethyl sulfoxide (DMSO) in tissue necrosis, genotoxicity, and cell apoptosis. Random skin flaps were made in 50 male Wistar rats, randomly divided into the following groups. Control group (CT), wherein a rectangular skin section (2 x 8 cm) was dissected from the dorsal muscle layer, preserving the cranial vessels, lifted, and refixed to the bed; distilled water (DW) group, in which DW was injected into the distal half of the skin flap; DMSO group, wherein 5% DMSO was injected; HBOT group, comprising animals treated only with HBOT; and HBOT + DMSO group, comprising animals treated with 100% oxygen at 2.5 atmospheres absolute for 1 h, 2 h after the experiment, daily for 10 consecutive days. A skinflap specimen investigated by microscopy. The percentage of necrosis was not significantly different between groups. The cell viability index was significantly different between groups (P < 0.001): 87.40% (CT), 86.20% (DW), 84.60% (DMSO), 86.60% (DMSO + HBO), and 91% (HBO) (P < 0.001), as was the cell apoptosis index of 12.60 (CT), 12.00 (DW), 15.40 (DMSO), 9.00 (HBO), and 12.00 (DMSO + HBO) (P < 0.001). The genotoxicity test revealed the percentage of cells with DNA damage to be 22.80 (CT), 22.60 (DW), 26.00 (DMSO), 8.80 (DMSO + HBO), and 7.20 (HBO) (P < 0.001). Although the necrotic area was not different between groups, there was a significant reduction in the cellular DNA damage and apoptosis index in the HBOT group.

Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88.

PubMed

Shao, Fenli; Tan, Tao; Tan, Yang; Sun, Yang; Wu, Xingxin; Xu, Qiang

2016-09-01

Psoriasis is a chronic inflammatory skin disease with excessive activation of toll-like receptors (TLRs), which play important roles in developing psoriasis. Targeting TLR signaling remains a challenge for treating psoriasis. Here, we found that andrographolide (Andro), a small-molecule natural product, alleviated imiquimod- but not interleukin 23 (IL-23)-induced psoriasis in mice with reducing expressions of IL-23 and IL-1β in the skin. The improvement in imiquimod-induced psoriasis by Andro was not observed in microtubule-associated protein 1 light chain 3 beta (MAP1LC3B) knockout mice. Furthermore, Andro inhibited mRNA expressions of IL-23, IL-6 and IL-1β but not CD80 and CD86 in bone-marrow derived dendritic cells (BMDCs) treated with lipopolysaccharide (LPS) in a MAP1LC3B-dependent manner. In addition, Andro inhibited imiquimod-induced mRNA expressions of IL-23, IL-6, IL-1β, CD80 and CD86 in BMDCs from mice. Interestingly, Andro induced a degradation of myeloid differentiation factor 88 (MyD88) and blocked the recruitment of TNF receptor-associated factor 6 (TRAF6) to MyD88 upon LPS stimulation in BMDCs from mice. Blockade of autophagic proteolysis using NH4Cl or MAP1LC3B(-/-) BMDCs abolished the Andro-induced MyD88 degradation. In conclusion, Andro controls activation of MyD88-dependent cytokines and alleviates psoriasis in mice via inducing autophagic proteolysis of MyD88, which could be a novel strategy to treat psoriasis. Copyright © 2016 Elsevier Inc. All rights reserved.

Biostratigraphy and chronostratigraphy of the area between Sarasota and Lake Okeechobee, southern Florida: An integrated approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wingard, G.L.; Edwards, L.E.; McCartan, L.

1993-03-01

Preliminary analysis of paleontologic and isotopic data from 15 coreholes, integrated with the lithostratigraphic framework, has revealed three chronostratigraphic depositional units in the subsurface of the Arcadia and Sarasota 30 [times] 60-minute quadrangles, in the southern Florida peninsula. (1) An upper Oligocene depositional unit unconformably overlies the lower Oligocene Suwannee Formation and has been dated by using [sup 87]Sr/[sup 86]Sr values and molluscs. (2) A lower and middle Miocene depositional unit has been dated on the basis of [sup 87]Sr/[sup 86]Sr values, molluscs, and dinoflagellates. The upper boundary of this unit is marked by the top of the Venice Claymore » in the western part of the study area. (3) A Pliocene and Pleistocene depositional unit, dated on the basis of [sup 87]Sr/[sup 86]Sr values, molluscs, dinoflagellates, foraminifera, ostracodes, and pollen, unconformably overlies the lower and middle Miocene beds; this unconformity represents approximately a 13-million-year gap in the record. The Pliocene and Pleistocene unit is seen in the surficial deposits of the Caloosahatchee, Tamiami, Bermont, and Fort Thompson Formations. The interpretation of Florida's geologic history is hampered by the interfingering of onlap/offlap cycles from two coastlines, a unique situation in southeastern coastal plain geology. In addition, a complex diagenetic history, mixing of carbonate and siliciclastic regimes, and lack of surface exposures make interpretation of the stratigraphic sequences difficult. The chronostratigraphic depositional units identified cut across lithofacies boundaries and allow correlation across the Florida peninsula, thus leading to the development of coherent, well-defined lithostratigraphic units.« less

Detection of bacteriuria and bacteremia in newborn calves by a catalase-based urine test.

PubMed

Raboisson, D; Clément, J; Queney, N; Lebreton, P; Schelcher, F

2010-01-01

Bacteremia occurs frequently in newborn calves. The predictive value of clinical signs is low, suggesting the use of calf-side diagnostic tests. To investigate testing of urine catalase activity (Uriscreen test) for bacteriuria and bacteremia detection. Five colostrum-free calves and 3 colostrum-fed control calves. Controlled experimental trial. Colostrum-free calves were inoculated PO with Escherichia coli O78+. A clinical score was established to define the onset of the illness. Blood and urine (cystocentesis) samplings and cultures, and Uriscreen tests, were performed 4-6 times from inoculation to death. Three control calves received the same management as 3 inoculated calves, but with colostrum and without inoculation. Bacteremia was demonstrated in all of the inoculated colostrum-free calves and in none of the control calves. The E. coli O78+ strain, E. coli, and Klebsiella spp. were recovered from 4/5, 5/5, and 2/5 inoculated colostrum-free calves, respectively. Urine cultures were negative for the 2 groups at the start of the experiment; 5/5 colostrum-deprived inoculated calves were positive for E. coli thereafter whereas 3/3 controls remained negative. Concordance of Uriscreen tests with bacteremia and bacteriuria was 0.86 and 0.88, respectively. Kappa value of agreement between Uriscreen and bacteremia and bacteriuria was 0.73 and 0.76, respectively. Sensitivity of Uriscreen for bacteremia and bacteriuria was 80.0 and 86.6%, respectively, and specificity was 92.8 and 88.8%, respectively. The results suggest that Uriscreen can be used for detection of bacteremia in neonatal calves in connection with a constant bacteriuria. Copyright © 2010 by the American College of Veterinary Internal Medicine.

Fragment distribution in 78,86Kr+181Ta reactions

NASA Astrophysics Data System (ADS)

Zhang, Dong-Hong; Zhang, Feng-Shou

2018-05-01

Within the framework of the isospin-dependent quantum molecular dynamics model, along with the GEMINI model, the 86Kr+181Ta reaction at 80, 120 and 160 MeV/nucleon and the 78Kr+181Ta reaction at 160 MeV/nucleon are studied, and the production cross sections of the generated fragments are calculated. More inter-mediate and large mass fragments can be produced in the reactions with a large range of impact parameter. The production cross sections of nuclei such as the isotopes of Si and P generally decrease with increasing incident energy. Isotopes near the neutron drip line are produced more in the neutron-rich system 86Kr+181Ta. Supported by Youth Research Foundation of Shanxi Datong University (2016Q10)

Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization.

PubMed

Cucak, Helena; Grunnet, Lars Groth; Rosendahl, Alexander

2014-01-01

Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and diminished insulin production. Local islet immunity is still poorly understood, and hence, we evaluated macrophage subpopulations in pancreatic islets in the well-established murine model of T2D, the db/db mouse. Already at 8 weeks of disease, on average, 12 macrophages were observed in the diabetic islets, whereas only two were recorded in the nondiabetic littermates. On a detailed level, the islet resident macrophages increased fourfold compared with nondiabetic littermates, whereas a pronounced recruitment (eightfold) of a novel subset of macrophages (CD68+F4/80-) was observed. The majority of the CD68+F4/80+ but only 40% of the CD68+F4/80- islet macrophages expressed CD11b. Both islet-derived macrophage subsets expressed moderate MHC-II, high galectin-3, and low CD80/CD86 levels, suggesting the cells to be macrophages rather than DCs. On a functional level, the vast majority of the macrophages in the diabetic islets was of the proinflammatory, M1-like phenotype. The systemic immunity in diabetic animals was characterized by a low-grade inflammation with elevated cytokine levels and increase of splenic cytokine, producing CD68+F4/80- macrophages. In late-stage diabetes, the cytokine signature changed toward a TGF-β-dominated profile, coinciding with a significant increase of galectin-3-positive macrophages in the spleen. In summary, our results show that proinflammatory M1-like galectin-3+ CD80/CD86(low) macrophages invade diabetic islets. Moreover, the innate immunity matures in a diabetes-dependent manner from an initial proinflammatory toward a profibrotic phenotype, supporting the concept that T2D is an inflammatory disease.

Test characteristics of the SD FK80 Plasmodium falciparum/Plasmodium vivax malaria rapid diagnostic test in a non-endemic setting

PubMed Central

2009-01-01

Background The SD FK80 P.f/P.v Malaria Antigen Rapid Test (Standard Diagnostics, Korea) (FK80) is a three-band malaria rapid diagnostic test detecting Plasmodium falciparum histidine-rich protein-2 (HRP-2) and Plasmodium vivax-specific lactate dehydrogenase (Pv-pLDH). The present study assessed its performance in a non-endemic setting. Methods Stored blood samples (n = 416) from international travellers suspected of malaria were used, with microscopy corrected by PCR as the reference method. Samples infected by Plasmodium falciparum (n = 178), Plasmodium vivax (n = 99), Plasmodium ovale (n = 75) and Plasmodium malariae (n = 24) were included, as well as 40 malaria negative samples. Results Overall sensitivities for the diagnosis of P. falciparum and P. vivax were 91.6% (95% confidence interval (CI): 86.2% - 95.0%) and 75.8% (65.9% - 83.6%). For P. falciparum, sensitivity at parasite densities ≥ 100/μl was 94.6% (88.8% - 97.6%); for P. vivax, sensitivity at parasite densities ≥ 500/μl was 86.8% (75.4% - 93.4%). Four P. falciparum samples showed a Pv-pLDH line, three of them had parasite densities exceeding 50.000/μl. Two P. vivax samples, one P. ovale and one P. malariae sample showed a HRP-2 line. For the HRP-2 and Pv-pLDH lines, respectively 81.4% (136/167) and 55.8% (43/77) of the true positive results were read as medium or strong line intensities. The FK80 showed good reproducibility and reliability for test results and line intensities (kappa values for both exceeding 0.80). Conclusion The FK80 test performed satisfactorily in diagnosing P. falciparum and P. vivax infections in a non-endemic setting. PMID:19930609

Efficacy of a web-based intervention with and without guidance for employees with risky drinking: results of a three-arm randomized controlled trial.

PubMed

Boß, Leif; Lehr, Dirk; Schaub, Michael Patrick; Paz Castro, Raquel; Riper, Heleen; Berking, Matthias; Ebert, David Daniel

2018-04-01

To test the efficacy of a web-based alcohol intervention with and without guidance. Three parallel groups with primary end-point after 6 weeks. Open recruitment in the German working population. Adults (178 males/256 females, mean age 47 years) consuming at least 21/14 weekly standard units of alcohol (SUA) and scoring ≥ 8/6 on the Alcohol Use Disorders Identification Test. Five web-based modules including personalized normative feedback, motivational interviewing, goal setting, problem-solving and emotion regulation during 5 weeks. One intervention group received an unguided self-help version (n=146) and the second received additional adherence-focused guidance by eCoaches (n=144). Controls were on a waiting list with full access to usual care (n=144). Primary outcome was weekly consumed SUA after 6 weeks. SUA after 6 months was examined as secondary outcome, next to numbers of participants drinking within the low-risk range, and general and work-specific mental health measures. All groups showed reductions of mean weekly SUA after 6 weeks (unguided: -8.0; guided: -8.5; control: -3.2). There was no significant difference between the unguided and guided intervention (P=0.324). Participants in the combined intervention group reported significantly fewer SUA than controls [B=-4.85, 95% confidence interval (CI)=-7.02 to -2.68, P < 0.001]. The intervention groups also showed significant reductions in SUA consumption after 6 months (B=-5.72, 95% CI=-7.71 to -3.73, P < 0.001) and improvements regarding general and work-related mental health outcomes after 6 weeks and 6 months. A web-based alcohol intervention, administered with or without personal guidance, significantly reduced mean weekly alcohol consumption and improved mental health and work-related outcomes in the German working population. © 2017 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.

Efficacy of a web‐based intervention with and without guidance for employees with risky drinking: results of a three‐arm randomized controlled trial

PubMed Central

Lehr, Dirk; Schaub, Michael Patrick; Paz Castro, Raquel; Riper, Heleen; Berking, Matthias; Ebert, David Daniel

2017-01-01

Abstract Aims To test the efficacy of a web‐based alcohol intervention with and without guidance. Design Three parallel groups with primary end‐point after 6 weeks. Setting Open recruitment in the German working population. Participants Adults (178 males/256 females, mean age 47 years) consuming at least 21/14 weekly standard units of alcohol (SUA) and scoring ≥ 8/6 on the Alcohol Use Disorders Identification Test. Intervention Five web‐based modules including personalized normative feedback, motivational interviewing, goal setting, problem‐solving and emotion regulation during 5 weeks. One intervention group received an unguided self‐help version (n=146) and the second received additional adherence‐focused guidance by eCoaches (n=144). Controls were on a waiting list with full access to usual care (n=144). Measurements Primary outcome was weekly consumed SUA after 6 weeks. SUA after 6 months was examined as secondary outcome, next to numbers of participants drinking within the low‐risk range, and general and work‐specific mental health measures. Findings All groups showed reductions of mean weekly SUA after 6 weeks (unguided: −8.0; guided: −8.5; control: −3.2). There was no significant difference between the unguided and guided intervention (P=0.324). Participants in the combined intervention group reported significantly fewer SUA than controls [B=−4.85, 95% confidence interval (CI)=−7.02 to −2.68, P < 0.001]. The intervention groups also showed significant reductions in SUA consumption after 6 months (B=−5.72, 95% CI=−7.71 to −3.73, P < 0.001) and improvements regarding general and work‐related mental health outcomes after 6 weeks and 6 months. Conclusions A web‐based alcohol intervention, administered with or without personal guidance, significantly reduced mean weekly alcohol consumption and improved mental health and work‐related outcomes in the German working population. PMID:29105879

[Renal biopsy practice in Piedmont and Valle d'Aosta].

PubMed

Manganaro, Marco; Nebiolo, Pier Eugenio; Rollino, Cristiana; Giacchino, Franca; Savoldi, Silvana; Besso, Luca; Colla, Loredana; Amore, Alessandro; Ferro, Michela; Marazzi, Federico; Chiarinotti, Doriana; Guarnieri, Andrea; Quaglia, Marco; Manes, Massimo; Vaccaro, Valentina; Marcuccio, Cristina; Licata, Carolina; Patti, Rosaria; Mariano, Filippo; Bongi, Anna Maria; Biamino, Ercole; Boschetti, Maria Antonietta; Della Volpe, Mario; Malcangi, Ugo; Baroni, Adriana; Vagelli, Giuseppe; Costantini, Luigia; Salomone, Mario; Formica, Marco; Caramello, Elisa; Campo, Andrea; Pignone, Eugenia; Messuerotti, Alessandra; Roccatello, Dario; Stratta, Piero; Segoloni, Giuseppe; Coppo, Rosanna

2012-01-01

In 2010 a questionnaire was administered to the renal units of Piedmont and Valle d'Aosta to analyze their procedures for renal biopsy (RB). Seventy-eight percent of units performed RBs, 57% for more than 20 years, but only 43% performed at least 20 BRs per year. 20/21 units performed RB in an inpatient setting and 1/21 in day hospital with the patient remaining under observation the night after. Thirty-two percent did not consider a single kidney as a contraindication to RB, 59% considered it a relative contraindication and 9% considered it an absolute contraindication. In 90.5% of units there was a specific protocol for patient preparation for RB and 86% used a specific informed consent form. Ninety-five percent of units performed ultrasound-guided RB, 60% of them using needle guides attached to the probe. In 81% of units the left side was preferred; 71% put a pillow under the patient's abdomen. All units used disposable, automated or semi-automated needles. Needle size was 16G in 29%, 18G in 58%, and both 16G and 18G in 14% of units; 1 to 3 samples were drawn. One third of units had a microscope available for immediate evaluation of specimen adequacy. After RB, 86% of units kept patients in the prone position for 2-6 hours and all prescribed a period of bed rest (at least 24 hours in 90.5%). 90.5% of units followed a specific postbiopsy observation protocol consisting of blood pressure, heart rate and red blood cell measurements at different times, and urine monitoring and ultrasound control within 12-24 hours (only half of them also employing color Doppler). One third of all units discharged patients after 1 day and two thirds after 2-3 days; all prescribed abstention from effort and from antiplatelet drugs for 7-15 days. In 9 units both RB and tissue processing and examination were done in the same hospital, while 12 units sent the samples elsewhere. 76% obtained results in 2-4 days, 19% in 6-7 days, and 5% in 10-15 days. Less than 20% of the interviewed operators were fully familiar with the clauses of hospital insurance securing their activity. Use of RB is widespread in Piedmont and Valle d'Aosta but its practice shows variation between centers.

A Study to Develop a Management Model for the Optimal Mix of Inpatient Services for Womack Army Community Hospital

DTIC Science & Technology

1988-07-01

Pneumonia and Pleurisy Age 0- 17) accounted for 80.645 admissions for 250 bed days and a cost of 86,370.80 dollars. For the Variable Y42 to remain in the...Pneumonia & Pleurisy Age 0-17 97 3.1 297 098 Bronchitis & Asthma Age 0-17 107 2.7 286 140 Angina Pectoris 94 4.2 392 143 Chest Pain 148 3.4 509 162

[Implication of inverse-probability weighting method in the evaluation of diagnostic test with verification bias].

PubMed

Kang, Leni; Zhang, Shaokai; Zhao, Fanghui; Qiao, Youlin

2014-03-01

To evaluate and adjust the verification bias existed in the screening or diagnostic tests. Inverse-probability weighting method was used to adjust the sensitivity and specificity of the diagnostic tests, with an example of cervical cancer screening used to introduce the Compare Tests package in R software which could be implemented. Sensitivity and specificity calculated from the traditional method and maximum likelihood estimation method were compared to the results from Inverse-probability weighting method in the random-sampled example. The true sensitivity and specificity of the HPV self-sampling test were 83.53% (95%CI:74.23-89.93)and 85.86% (95%CI: 84.23-87.36). In the analysis of data with randomly missing verification by gold standard, the sensitivity and specificity calculated by traditional method were 90.48% (95%CI:80.74-95.56)and 71.96% (95%CI:68.71-75.00), respectively. The adjusted sensitivity and specificity under the use of Inverse-probability weighting method were 82.25% (95% CI:63.11-92.62) and 85.80% (95% CI: 85.09-86.47), respectively, whereas they were 80.13% (95%CI:66.81-93.46)and 85.80% (95%CI: 84.20-87.41) under the maximum likelihood estimation method. The inverse-probability weighting method could effectively adjust the sensitivity and specificity of a diagnostic test when verification bias existed, especially when complex sampling appeared.

Association of time in blood glucose range with outcomes following cardiac surgery.

PubMed

Omar, Amr S; Salama, Ahmed; Allam, Mahmoud; Elgohary, Yasser; Mohammed, Shaban; Tuli, Alejandro Kohn; Singh, Rajvir

2015-01-01

The importance of optimal postoperative glycemic control in cardiac patients remains unclear. Various glycemic targets have been prescribed to reduce wound infection and overall mortality rates. To assess glucose control, as determined by time in range (TIR), in patients with glycemic targets of 6.0 to 8.1 mmol/L, and to determine factors related to poor control. This prospective descriptive study evaluated 227 consecutive patients, 100 with and 127 without diabetes, after cardiac surgery. Patients received insulin to target glucose concentrations of 6.0 to 8.1 mmol/L. Data analyzed included patient age, gender, race, Euro score, cardiopulmonary bypass time (CPB), aortic cross clamp time (ACC), length of ventilation, stay in the intensive care unit (ICU) and stay in the hospital. Patients were divided into two groups, those who maintained > 80% and < 80% TIR. Outcome variables were compared in diabetics and non-diabetics. Patients with >80% and <80% TIR were matched in age, sex, gender, and Euro score. Failure to maintain target glycemia was significantly more frequent in diabetics (p = 0.001), in patients with glycated hemoglobin (HbA1c) > 8% (p = 0.0001), and in patients taking dopamine (p = 0.04) and adrenaline (p = 0.05). Times of CPB and ACC, length of stay in the ICU and ventilation were significantly higher in patients with TIR <80% than >80%. Rates of hypoglycemia, acute kidney injury, and in-hospital mortality were similar in the two groups, although the incidence of wound infection was higher in patients with TIR <80%. Both diabetics and non-diabetics with low TIR had poorer outcomes, as shown by length of stay and POAF. No significant differences were found between the two ethnic groups (Arabs and Asians). Patients with >80% TIR, whether or not diabetics, had better outcomes than those with <80% TIR, as determined by wound infection, lengths of ventilation and ICU stay. Additionally, they were not subject to frequent hypoglycemic events. Preoperatively high HbA1C is likely a good predictor of poor glycemic control.

Improved uniformity in high-performance organic photovoltaics enabled by (3-aminopropyl)triethoxysilane cathode functionalization.

PubMed

Luck, Kyle A; Shastry, Tejas A; Loser, Stephen; Ogien, Gabriel; Marks, Tobin J; Hersam, Mark C

2013-12-28

Organic photovoltaics have the potential to serve as lightweight, low-cost, mechanically flexible solar cells. However, losses in efficiency as laboratory cells are scaled up to the module level have to date impeded large scale deployment. Here, we report that a 3-aminopropyltriethoxysilane (APTES) cathode interfacial treatment significantly enhances performance reproducibility in inverted high-efficiency PTB7:PC71BM organic photovoltaic cells, as demonstrated by the fabrication of 100 APTES-treated devices versus 100 untreated controls. The APTES-treated devices achieve a power conversion efficiency of 8.08 ± 0.12% with histogram skewness of -0.291, whereas the untreated controls achieve 7.80 ± 0.26% with histogram skewness of -1.86. By substantially suppressing the interfacial origins of underperforming cells, the APTES treatment offers a pathway for fabricating large-area modules with high spatial performance uniformity.

40 CFR 86.1717-99 - Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. 86.1717-99 Section 86.1717-99 Protection of... diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. (a) The provisions of § 86...

40 CFR 86.1717-01 - Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. 86.1717-01 Section 86.1717-01 Protection of... diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. (a) The provisions of § 86...

40 CFR 86.1717-99 - Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. 86.1717-99 Section 86.1717-99 Protection of... diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. (a) The provisions of § 86...

40 CFR 86.1717-01 - Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Emission control diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. 86.1717-01 Section 86.1717-01 Protection of... diagnostic system for 1999 and later light-duty vehicles and light-duty trucks. (a) The provisions of § 86...

[Silent myocardial ischemia in patients with transient ischemic attacks].

PubMed

Sánchez Valiente, S; Mostacero, E; del Río, A; Morales, F

1994-10-01

Given evidence that ischemic heart disease is the most frequent cause of death in patients with cerebrovascular disease, we used ergometrics to screen 80 patients with TIA for silent myocardial ischemia (SMI) at the neurological unit of Hospital Clínico Universitario in Zaragoza, Spain. The patients were compared with a control group of 80 with no signs of heart disease. Neither the patients nor the controls had ever shown clinical signs of coronary ischemia and their baseline electrocardiograms were normal. Stress test results were positive in 25 (31%) of the TIA patients, and in 4 (5%) (p < 0.001) of the controls, showing that the prevalence of SMI is significantly higher in TIA patients than in the general population. Hiperlipidemia (75% testing positive versus 43% negative, p < 0.01) and diabetes (31% testing positive versus 13% negative, p < 0.01) were the risk factors statistically related with a positive stress test.

Polymerization of a dual-cured cement through ceramic: LED curing light vs halogen lamp.

PubMed

Lopes, Lawrence Gonzaga; Franco, Eduardo Batista; Name Neto, Abrão; Herrera, Francyle S; Kurachi, Cristina; Castañeda-Espinosa, Juan C; Lauris, José Roberto Pereira

2004-12-01

The aim of this study was to investigate the influence of light source, LED unit and halogen lamp (HL), on the effectiveness of Enforce dual-cured cement cured under a ceramic disc. Three exposure times (60, 80 and 120 s) were also evaluated. Two experimental groups, in which the polymerization of the dual-cured cement was performed through a ceramic disc, and two control groups, in which the polymerization of the dual-cured cement was performed directly without presence of ceramic disc were subdivided into three subgroups (three different exposure times), with five specimens each: G1A- HL 60s; G1B- HL 80s; G1C- HL 120s; G2A- LED 60s; G2B- LED 80s; G2C- LED 120s; and control groups: G3A- HL 60s; G3B- HL 80s; G3C- HL 120s; G4A- LED 60s; G4B- LED 80s and G4C- LED 120s. Cement was applied in a steel matrix (4mm diameter, 1.2mm thickness). In the experimental groups, a ceramic disc was placed on top. The cement was light-cured through the ceramic by a HL and LED, however, the control groups were cured without the ceramic disc. The specimens were stored in a light-proof container at 37ºC for 24 hours, then Vickers hardness was determined. A four-way ANOVA and Tukey test (p£ 0.05) were performed. All specimens cured by LED for 60s showed inferior values compared with the halogen groups. In general, light-curing by LED for 80s and 120s was comparable to halogen groups (60s and 80s) and their control groups. LED technology can be viable for light-curing through conventional ceramic indirect restorations, when curing time is increased in relation to HL curing time.

Efficiency of dual-cured resin cement polymerization induced by high-intensity LED curing units through ceramic material.

PubMed

Watanabe, H; Kazama, Re; Asai, T; Kanaya, F; Ishizaki, H; Fukushima, M; Okiji, T

2015-01-01

This study aimed to evaluate the ability of high-intensity light-emitting diode (LED) and other curing units to cure dual-cured resin cement through ceramic material. A halogen curing unit (Jetlite 3000, Morita), a second-generation LED curing unit (Demi, Kerr), and two high-intensity LED curing units (PenCure 2000, Morita; Valo, Ultradent) were tested. Feldspathic ceramic plates (VITABLOCS Mark II, A3; Vita Zahnfabrik) with thicknesses of 1.0, 2.0, and 3.0 mm were prepared. Dual-cured resin cement samples (Clearfil Esthetic Cement, Kuraray Noritake Dental) were irradiated directly or through one of the ceramic plates for different periods (5, 10, 15, or 20 seconds for the high-intensity LED units and 20, 40, 60, or 80 seconds for the others). The Knoop hardness test was used to determine the level of photopolymerization that had been induced in the resin cement. Data were analyzed by one-way analysis of variance and Dunnett's post-hoc test to identify test-control (maximum irradiation without a ceramic plate) differences for each curing unit (p<0.05). For all curing units, the curing conditions had a statistically significant effect on the Knoop hardness numbers (KHNs) of the irradiated cement samples (p<0.001). In general, the KHN decreased with increasing plate thickness and increased as the irradiation period was extended. Jetlite 3000 achieved control-level KHN values only when the plate thickness was 1.0 mm. At a plate thickness ≥2.0 mm, the LED units (except for PenCure 2000 at 3.0 mm) were able to achieve control-level KHN values when the irradiation time was extended. At a plate thickness of 3.0 mm, irradiation for 20 seconds with the Valo or for 80 seconds with the Demi were the only methods that produced KHN values equivalent to those produced by direct irradiation. Regardless of the type of curing unit used, indirect irradiation of dual-cured resin cement through a ceramic plate resulted in decreased KHN values compared with direct irradiation. When the irradiation period was extended, only the LED units were able to achieve similar KHN values to those observed under direct irradiation in the presence of plates ≥2.0-mm thick. High-intensity LED units require a shorter irradiation period than halogen and second-generation LED curing units to obtain KHN values similar to those observed during direct irradiation.

Temperament and fracture in preschool-aged children.

PubMed

Ryckman, Kandace; Richmond, Sarah A; Anderson, Laura N; Birken, Catherine S; Parkin, Patricia C; Macarthur, Colin; Maguire, Jonathon L; Howard, Andrew W

2017-07-01

Approximately one-half of all children will sustain a fracture before adulthood. Understanding the factors that place a child at increased risk of fracture is necessary to inform effective injury prevention strategies. The purpose of this study was to examine the association between temperament and fracture risk in preschool-aged children. Children aged 3 to 6 years who were diagnosed with a fracture were recruited from the Hospital for Sick Children Fracture Clinic. Using a retrospective case-control study design, the 148 cases were frequency-matched by age and sex to 426 controls from the TARGet Kids primary care paediatric cohort. The Childhood Behaviour Questionnaire, a 36-item caregiver response questionnaire was used to assess three of the following temperament factors: surgency (e.g., high activity level), negative affect (e.g., anger, fear, discomfort) and effortful control (e.g., attentional focusing). Unadjusted logistic models demonstrated no association between children with previous fracture and higher scores of surgency (unadjusted odds ratio [OR]=1.06, 95% confidence interval [CI]: 0.84, 1.34), negative affect (unadjusted OR=1.15, 95% CI: 0.93, 1.42) or effortful control (unadjusted OR=0.80, 95% CI: 0.63, 1.03). Further, models adjusted for covariates also demonstrated no significant association with surgency (1.00, 95% CI: 0.78, 1.29), negative affect (1.09, 95% CI: 0.86, 1.37) and effortful control (0.80, 95% CI: 0.61, 1.05). None of the three main temperament types identified by the Childhood Behaviour Questionnaire were associated with an increase in fracture risk.

Directional Selectivity for FM Sweeps in the Suprageniculate Nucleus of the Mustached Bat Medial Geniculate Body

PubMed Central

O’NEILL, WILLIAM E.; BRIMIJOIN, W. OWEN

2014-01-01

Mustached bats emit echolocation and communication calls containing both constant frequency (CF) and frequency-modulated (FM) components. Previously we found that 86% of neurons in the ventral division of the external nucleus of the inferior colliculus (ICXv) were directionally selective for linear FM sweeps and that selectivity was dependent on sweep rate. The ICXv projects to the suprageniculate nucleus (Sg) of the medial geniculate body. In this study, we isolated 37 single units in the Sg and measured their responses to best excitatory frequency (BEF) tones and linear 12-kHz upward and downward FM sweeps centered on the BEF. Sweeps were presented at durations of 30, 12, and 4 ms, yielding modulation rates of 400, 1,000, and 3,000 kHz/s. Spike count versus level functions were obtained at each modulation rate and compared with BEF controls. Sg units responded well to both tones and FM sweeps. BEFs clustered at 58 kHz, corresponding to the dominant CF component of the sonar signal. Spike count functions for both tones and sweeps were predominantly non-monotonic. FM directional selectivity was significant in 53–78% of the units, depending on modulation rate and level. Units were classified as up-selective (52%), down-selective (24%), or bi-directional (non-selective, 16%); a few units (8%) showed preferences that were either rate- or level-dependent. Most units showed consistent directional preferences at all SPLs and modulation rates tested, but typically showed stronger selectivity at lower sweep rates. Directional preferences were attributable to suppression of activity by sweeps in the non-preferred direction (~80% of units) and/or facilitation by sweeps in the preferred direction (~20–30%). Latencies for BEF tones ranged from 4.9 to 25.7 ms. Latencies for FM sweeps typically varied linearly with sweep duration. Most FM latency-duration functions had slopes ranging from 0.4 to 0.6, suggesting that the responses were triggered by the BEF. Latencies for BEF tones and FM sweeps were significantly correlated in most Sg units, i.e., the response to FM was temporally related to the occurrence of the BEF in the FM sweep. FM latency declined relative to BEF latency as modulation rate increased, suggesting that at higher rates response is triggered by frequencies in the sweep preceding the BEF. We conclude that Sg and ICXv units have similar, though not identical, response properties. Sg units are predominantly upsweep selective and could respond to either or both the CF and FM components in biosonar signals in a number of echolocation scenarios, as well as to a variety of communication sounds. PMID:12091543

Sawtimber oak stand response to six distinct cutting methods

Treesearch

Jeffery S. Ward; George R. Stephens

2003-01-01

Nonindustrial private owners control over 80 percent of the 50 million acres of oak-dominated forest in the northern United States. Although non-commodity amenities are more important than timber production for many of these owners, the expense of forest ownership may make them amenable to forest management practices that provide income while retaining the desired non-...

Cytisus scoparius (L.) Link: Scotch broom

Treesearch

Susan E. Meyer

2008-01-01

The genus Cytisus comprises about 80 species native to Eurasia and North Africa. Many are cultivated as ornamentals, and several of these have become more or less naturalized in the United States, especially in California (Munz and Keck 1959). Scotch broom - C. scoparius (L.) Link - was planted extensively for erosion control during the first half of the century (Gill...

40 CFR 86.429-78 - Maintenance, unscheduled; test vehicles.

Code of Federal Regulations, 2013 CFR

2013-07-01

... vehicles. 86.429-78 Section 86.429-78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES..., unscheduled; test vehicles. (a) Any unscheduled engine, emission control system, or fuel system adjustment...

42 CFR 476.86 - Correlation of Title XI functions with Title XVIII functions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... functions. 476.86 Section 476.86 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control Quality Improvement Organizations (QIOs...

The prevalence of dental erosion in 5-year-old preschoolers in Sharjah, United Arab Emirates.

PubMed

Gopinath, Vellore Kannan

2016-01-01

The aim of this study was to determine the percentage of 5-year-old preschoolers in Sharjah, affected by dental erosion and to assess the predictors. A total of 403 5-year-old children were examined of which 48.14% (n = 194) were boys and 51.86% (n = 209) were girls; 31.27% (n = 126) were Emirati and 68.73% (n = 277) were non-Emirati Arabs. Examination of dental erosion was confined to palatal surfaces of maxillary incisors using the erosion index described in the UK National Survey of Children's Dental Health, 1993. Dental caries was charted using the World Health Organization 1997 criteria. In the sample of 403 5-year-old preschoolers examined, dental erosion was apparent in 237 (58.80%) children, with 55.09% showing the dissolution of enamel and 3.72% exhibiting exposed dentin. Predictors of dental erosion as determined by logistic regression concluded that compared to Emirati citizens other Arab nationalities have 0.27 times the odds (95% confidence interval [CI] =0.18-0.42) of having tooth erosion (P < 0.05). Children with caries experience have 0.28 times the odds (95% CI = 0.16-0.51) of having tooth erosion compared to children with no caries experience (P < 0.05). Children who drink sugary or carbonated beverages have 0.30 times the odds (95% CI = 0.19-0.41) of having dental erosion compared to children who drink water (P < 0.05). The findings of this study indicate that 58.80% of 5-year-old preschoolers in Sharjah, United Arab Emirates, were affected by dental erosion. Caries experience and consumption of acidic drinks were associated with dental erosion.

The prevalence of dental erosion in 5-year-old preschoolers in Sharjah, United Arab Emirates

PubMed Central

Gopinath, Vellore Kannan

2016-01-01

Objective: The aim of this study was to determine the percentage of 5-year-old preschoolers in Sharjah, affected by dental erosion and to assess the predictors. Materials and Methods: A total of 403 5-year-old children were examined of which 48.14% (n = 194) were boys and 51.86% (n = 209) were girls; 31.27% (n = 126) were Emirati and 68.73% (n = 277) were non-Emirati Arabs. Examination of dental erosion was confined to palatal surfaces of maxillary incisors using the erosion index described in the UK National Survey of Children's Dental Health, 1993. Dental caries was charted using the World Health Organization 1997 criteria. Results: In the sample of 403 5-year-old preschoolers examined, dental erosion was apparent in 237 (58.80%) children, with 55.09% showing the dissolution of enamel and 3.72% exhibiting exposed dentin. Predictors of dental erosion as determined by logistic regression concluded that compared to Emirati citizens other Arab nationalities have 0.27 times the odds (95% confidence interval [CI] =0.18–0.42) of having tooth erosion (P < 0.05). Children with caries experience have 0.28 times the odds (95% CI = 0.16–0.51) of having tooth erosion compared to children with no caries experience (P < 0.05). Children who drink sugary or carbonated beverages have 0.30 times the odds (95% CI = 0.19–0.41) of having dental erosion compared to children who drink water (P < 0.05). Conclusions: The findings of this study indicate that 58.80% of 5-year-old preschoolers in Sharjah, United Arab Emirates, were affected by dental erosion. Caries experience and consumption of acidic drinks were associated with dental erosion. PMID:27095899

34 CFR 400.3 - What other regulations apply to the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... applicable to parts 401, 410, 411, 413, 418, and 419). (6) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

34 CFR 400.3 - What other regulations apply to the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2013 CFR

2013-07-01

... applicable to parts 401, 410, 411, 413, 418, and 419). (6) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

34 CFR 400.3 - What other regulations apply to the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2012 CFR

2012-07-01

... applicable to parts 401, 410, 411, 413, 418, and 419). (6) 34 CFR part 80 (Uniform Administrative... Governmentwide Requirements for Drug-Free Workplace (Grants)). (10) 34 CFR part 86 (Drug-Free Schools and...

45 CFR 86.13 - Military and merchant marine educational institutions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE... educational institution whose primary purpose is the training of individuals for a military service of the United States or for the merchant marine. (Secs. 901, 902, Education Amendments of 1972, 86 Stat. 373...

40 CFR 97.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Individual Unit Opt-ins. § 97.86 Withdrawal from NOX Budget Trading Program. (a) Requesting withdrawal. To...

40 CFR 97.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Individual Unit Opt-ins. § 97.86 Withdrawal from NOX Budget Trading Program. (a) Requesting withdrawal. To...

STS-86 Mission Specialist David Wolf in white room

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 Mission Specialist David A. Wolf, at center facing camera, prepares to enter the Space Shuttle Atlantis at Launch Pad 39A, with the assistance of Rick Welty, in foreground at center, United Space Alliance (USA) orbiter vehicle closeout chief; and closeout team members, in background from left, Jim Davis, NASA quality assurance specialist; and George Schramm, USA mechanical technician. STS-86 Mission Specialist Vladimir Georgievich Titov, in foreground at far left, is awaiting his turn.

Sub-Saharan Africa Report.

DTIC Science & Technology

1987-01-16

Botha (DIE AFRIKANER, 8 Oct 86) 55 s 57 (DIE AFRIKANER, 15 Oct 86) 59 BP Oil Company Integration Plans Viewed (DIE BURGER, 17 Nov 86...among things, ban the transporta- tion of crude oil to South Africa and Namibia on Norwegian ships, ban any form of investment and trans- fer of...on November 10 on an em- bargo against the sale and transport of oil to South Africa, and calls for the setting up of a United Nations "mechanism

[Individual, community, regulatory, and systemic approaches to tobacco control interventions].

PubMed

Gorini, Giuseppe

2011-01-01

During the 60s and the 70s strategies for decreasing initiation or quitting have been developed, in order to find those with high success rates. Unfortunately, interventions with an individual approach involved few smokers, so their impact in decreasing smoking prevalence was limited. The socio-ecological model offers a theoretical framework to community interventions for smoking cessation developed during the 80s, in which smoking was considered not only an individual, but also a social problem. In the 80s and the 90s smoking cessation community trials were developed, such as the Community Intervention Trial for Smoking Cessation (COMMIT). Afterwards, policy interventions (price policy; smoking bans in public places; advertising bans; bans of sales to minors) were developed, such as the American Stop Smoking Intervention Study for Cancer Prevention (ASSIST). California has been the first State all over the world to develop a comprehensive Tobacco Control Program in 1988, becoming the place for an ever-conducted natural experiment. All policy interventions in tobacco control have been finally grouped together in the World Health Organization - Framework Convention on Tobacco Control (WHO-FCTC), the first Public Health Treaty. Study designs have changed, according to the individual, community, or regulatory approaches: the classical randomized controlled trials (RCTs), in which the sampling unit is the individual, have been carried out for the evaluation of smoking cessation treatments, whereas cluster RCTs, in which the sampling unit is the community, have been conducted for evaluating community interventions, such as COMMIT. Finally, quasi-experimental studies (before/after study; prospective cohorts, both with a control group), in which the observational unit is a State, have been used for evaluating tobacco control policies, such as ASSIST and the International Tobacco Control Policy Evaluation Project. Although the successes of the last 20 years, tobacco control is at a critical point: in a reductionist approach, we tried to study its parts, but few efforts have been done to consider tobacco control as a complex network that needs an alternative approach to be understood, the systems thinking approach. New attempts of understanding and solving contradictions within tobacco control using a systems thinking approach are presented.

40 CFR 86.001-23 - Required data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Required data. 86.001-23 Section 86...-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.001-23 Required data. Section 86.001-23 includes text...-emission control system combination and all test data that are derived from testing described under § 86...

High-cycle-life, high-energy-density nickel-zinc batteries

NASA Astrophysics Data System (ADS)

Wagner, O. C.

1982-02-01

The ERADCOM nickel-zinc program, resulted in the development of 5 ampere-hour nickel-zinc cells that maintained 79% to 86% of initial capacity after 650 cycles on the C/3 80% DOD cycling regime. One cell is still delivering 70% of initial capacity after 880 cycles. This achievement is primarily due to the employment of an interrupted current (IC) charging mode on every cycle, the optimum frequency being 5 to 8 Hertz at a rest-to-pulse-ratio of 3/1, with charge control being by means of a GRL pressure switch attached to each cell at a cutoff pressure of 8 psig, and venting means at 10 psig. Design and performance characteristics of the battery are reported.

Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease.

PubMed

Dezfoli, Seper; Horton, Henry A; Thepyasuwan, Nattapaun; Berel, Dror; Targan, Stephan R; Vasiliauskas, Eric A; Dubinsky, Marla; Shih, David Q; Kaur, Manreet; McGovern, Dermot P B; Ippoliti, Andrew; Feldman, Edward J; Melmed, Gil Y

2015-08-01

Pertussis epidemics have recently emerged across the United States, prompting broad public health recommendations for adult Tdap vaccination (tetanus, diphtheria, acellular pertussis). The impact of immunosuppressive regimens for inflammatory bowel disease (IBD) on vaccine responses to the Tdap vaccine is not known. We performed a prospective controlled trial between April 2011 and March 2012. Adults with IBD were consecutively stratified based on therapeutic regimen into one of 5 groups: A: no IBD therapy or 5-aminosalicylates alone; B: maintenance biologic monotherapy; C: maintenance immunomodulator monotherapy; D: combined biologic and immunomodulator therapy; and E: healthy age-matched controls. Subjects received Tdap, and serum antibody levels against tetanus toxoid, pertussis toxoid, and filamentous hemagglutinin (FHA) were drawn just before and approximately 4 weeks after vaccination. The primary outcome was the booster response rate to each antigen. Secondary outcomes included the differences in pregeometric and postgeometric mean titers. A total of 98 subjects enrolled, and 84 completed the study. Tetanus response rates were 55%, 56%, 40%, 27%, and 63% across groups A to E, respectively. Group D rates were lower than those of group B (P = 0.02). Postvaccination pertussis toxoid responses were 59%, 72%, 47%, 45%, and 75%, while FHA responses were 86%, 72%, 80%, 64%, and 75% across groups A to E, respectively. Prevaccination and postvaccination geometric mean titer differences for FHA were lower in group D than those in group A (P = 0.05). Antibody responses to tetanus and pertussis vaccination may be affected by therapeutic drug regimen. Patients with IBD should optimally receive Tdap before starting immunomodulators, particularly when used in combination with anti-tumor necrosis factor alpha agents.

An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production

PubMed Central

Hristov, Alexander N.; Oh, Joonpyo; Giallongo, Fabio; Frederick, Tyler W.; Harper, Michael T.; Weeks, Holley L.; Branco, Antonio F.; Moate, Peter J.; Deighton, Matthew H.; Williams, S. Richard O.; Kindermann, Maik; Duval, Stephane

2015-01-01

A quarter of all anthropogenic methane emissions in the United States are from enteric fermentation, primarily from ruminant livestock. This study was undertaken to test the effect of a methane inhibitor, 3-nitrooxypropanol (3NOP), on enteric methane emission in lactating Holstein cows. An experiment was conducted using 48 cows in a randomized block design with a 2-wk covariate period and a 12-wk data collection period. Feed intake, milk production, and fiber digestibility were not affected by the inhibitor. Milk protein and lactose yields were increased by 3NOP. Rumen methane emission was linearly decreased by 3NOP, averaging about 30% lower than the control. Methane emission per unit of feed dry matter intake or per unit of energy-corrected milk were also about 30% less for the 3NOP-treated cows. On average, the body weight gain of 3NOP-treated cows was 80% greater than control cows during the 12-wk experiment. The experiment demonstrated that the methane inhibitor 3NOP, applied at 40 to 80 mg/kg feed dry matter, decreased methane emissions from high-producing dairy cows by 30% and increased body weight gain without negatively affecting feed intake or milk production and composition. The inhibitory effect persisted over 12 wk of treatment, thus offering an effective methane mitigation practice for the livestock industries. PMID:26229078

An inhibitor persistently decreased enteric methane emission from dairy cows with no negative effect on milk production.

PubMed

Hristov, Alexander N; Oh, Joonpyo; Giallongo, Fabio; Frederick, Tyler W; Harper, Michael T; Weeks, Holley L; Branco, Antonio F; Moate, Peter J; Deighton, Matthew H; Williams, S Richard O; Kindermann, Maik; Duval, Stephane

2015-08-25

A quarter of all anthropogenic methane emissions in the United States are from enteric fermentation, primarily from ruminant livestock. This study was undertaken to test the effect of a methane inhibitor, 3-nitrooxypropanol (3NOP), on enteric methane emission in lactating Holstein cows. An experiment was conducted using 48 cows in a randomized block design with a 2-wk covariate period and a 12-wk data collection period. Feed intake, milk production, and fiber digestibility were not affected by the inhibitor. Milk protein and lactose yields were increased by 3NOP. Rumen methane emission was linearly decreased by 3NOP, averaging about 30% lower than the control. Methane emission per unit of feed dry matter intake or per unit of energy-corrected milk were also about 30% less for the 3NOP-treated cows. On average, the body weight gain of 3NOP-treated cows was 80% greater than control cows during the 12-wk experiment. The experiment demonstrated that the methane inhibitor 3NOP, applied at 40 to 80 mg/kg feed dry matter, decreased methane emissions from high-producing dairy cows by 30% and increased body weight gain without negatively affecting feed intake or milk production and composition. The inhibitory effect persisted over 12 wk of treatment, thus offering an effective methane mitigation practice for the livestock industries.

Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis.

PubMed

Lau, Susanna K P; Lee, Kim-Chung; Curreem, Shirly O T; Chow, Wang-Ngai; To, Kelvin K W; Hung, Ivan F N; Ho, Deborah T Y; Sridhar, Siddharth; Li, Iris W S; Ding, Vanessa S Y; Koo, Eleanor W F; Wong, Chi-Fong; Tam, Sidney; Lam, Ching-Wan; Yuen, Kwok-Yung; Woo, Patrick C Y

2015-12-01

Although tuberculosis (TB) is a reemerging disease that affects people in developing countries and immunocompromised populations in developed countries, the current diagnostic methods are far from optimal. Metabolomics is increasingly being used for studies on infectious diseases. We performed metabolome profiling of plasma samples to identify potential biomarkers for diagnosing TB. We compared the plasma metabolome profiles of TB patients (n = 46) with those of community-acquired pneumonia (CAP) patients (n = 30) and controls without active infection (n = 30) using ultrahigh-performance liquid chromatography-electrospray ionization-quadrupole time of flight mass spectrometry (UHPLC-ESI-QTOFMS). Using multivariate and univariate analyses, four metabolites, 12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid [12(R)-HETE], ceramide (d18:1/16:0), cholesterol sulfate, and 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol, were identified and found to have significantly higher levels in TB patients than those in CAP patients and controls. In a comparison of TB patients and controls, the four metabolites demonstrated area under the receiver operating characteristic curve (AUC) values of 0.914, 0.912, 0.905, and 0.856, sensitivities of 84.8%, 84.8%, 87.0%, and 89.1%, specificities of 90.0%, 86.7%, 86.7%, and 80.0%, and fold changes of 4.19, 26.15, 6.09, and 1.83, respectively. In a comparison of TB and CAP patients, the four metabolites demonstrated AUC values of 0.793, 0.717, 0.802, and 0.894, sensitivities of 89.1%, 71.7%, 80.4%, and 84.8%, specificities of 63.3%, 66.7%, 70.0%, and 83.3%, and fold changes of 4.69, 3.82, 3.75, and 2.16, respectively. 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol combined with 12(R)-HETE or cholesterol sulfate offered ≥70% sensitivity and ≥90% specificity for differentiating TB patients from controls or CAP patients. These novel plasma biomarkers, especially 12(R)-HETE and 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol, alone or in combination, are potentially useful for rapid and noninvasive diagnosis of TB. The present findings may offer insights into the pathogenesis and host response in TB. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis

PubMed Central

Lee, Kim-Chung; Curreem, Shirly O. T.; To, Kelvin K. W.; Hung, Ivan F. N.; Ho, Deborah T. Y.; Sridhar, Siddharth; Li, Iris W. S.; Ding, Vanessa S. Y.; Koo, Eleanor W. F.; Wong, Chi-Fong; Tam, Sidney; Lam, Ching-Wan; Yuen, Kwok-Yung

2015-01-01

Although tuberculosis (TB) is a reemerging disease that affects people in developing countries and immunocompromised populations in developed countries, the current diagnostic methods are far from optimal. Metabolomics is increasingly being used for studies on infectious diseases. We performed metabolome profiling of plasma samples to identify potential biomarkers for diagnosing TB. We compared the plasma metabolome profiles of TB patients (n = 46) with those of community-acquired pneumonia (CAP) patients (n = 30) and controls without active infection (n = 30) using ultrahigh-performance liquid chromatography–electrospray ionization-quadrupole time of flight mass spectrometry (UHPLC-ESI-QTOFMS). Using multivariate and univariate analyses, four metabolites, 12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid [12(R)-HETE], ceramide (d18:1/16:0), cholesterol sulfate, and 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol, were identified and found to have significantly higher levels in TB patients than those in CAP patients and controls. In a comparison of TB patients and controls, the four metabolites demonstrated area under the receiver operating characteristic curve (AUC) values of 0.914, 0.912, 0.905, and 0.856, sensitivities of 84.8%, 84.8%, 87.0%, and 89.1%, specificities of 90.0%, 86.7%, 86.7%, and 80.0%, and fold changes of 4.19, 26.15, 6.09, and 1.83, respectively. In a comparison of TB and CAP patients, the four metabolites demonstrated AUC values of 0.793, 0.717, 0.802, and 0.894, sensitivities of 89.1%, 71.7%, 80.4%, and 84.8%, specificities of 63.3%, 66.7%, 70.0%, and 83.3%, and fold changes of 4.69, 3.82, 3.75, and 2.16, respectively. 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol combined with 12(R)-HETE or cholesterol sulfate offered ≥70% sensitivity and ≥90% specificity for differentiating TB patients from controls or CAP patients. These novel plasma biomarkers, especially 12(R)-HETE and 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol, alone or in combination, are potentially useful for rapid and noninvasive diagnosis of TB. The present findings may offer insights into the pathogenesis and host response in TB. PMID:26378277

Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations.

PubMed

Zhang, Yan; Yang, Jing; Zhang, Jing; Sun, Liangdan; Hirankarn, Nattiya; Pan, Hai-Feng; Lau, Chak Sing; Chan, Tak Mao; Lee, Tsz Leung; Leung, Alexander Moon Ho; Mok, Chi Chiu; Zhang, Lu; Wang, Yongfei; Shen, Jiangshan Jane; Wong, Sik Nin; Lee, Ka Wing; Ho, Marco Hok Kung; Lee, Pamela Pui Wah; Chung, Brian Hon-Yin; Chong, Chun Yin; Wong, Raymond Woon Sing; Mok, Mo Yin; Wong, Wilfred Hing Sang; Tong, Kwok Lung; Tse, Niko Kei Chiu; Li, Xiang-Pei; Avihingsanon, Yingyos; Rianthavorn, Pornpimol; Deekajorndej, Thavatchai; Suphapeetiporn, Kanya; Shotelersuk, Vorasuk; Ying, Shirley King Yee; Fung, Samuel Ka Shun; Lai, Wai Ming; Wong, Chun-Ming; Ng, Irene Oi Lin; Garcia-Barcelo, Maria-Merce; Cherny, Stacey S; Cui, Yong; Sham, Pak Chung; Yang, Sen; Ye, Dong-Qing; Zhang, Xue-Jun; Lau, Yu Lung; Yang, Wanling

2016-05-01

Genetic interaction has been considered as a hallmark of the genetic architecture of systemic lupus erythematosus (SLE). Based on two independent genome-wide association studies (GWAS) on Chinese populations, we performed a genome-wide search for genetic interactions contributing to SLE susceptibility. The study involved a total of 1 659 cases and 3 398 controls in the discovery stage and 2 612 cases and 3 441 controls in three cohorts for replication. Logistic regression and multifactor dimensionality reduction were used to search for genetic interaction. Interaction of CD80 (rs2222631) and ALOX5AP (rs12876893) was found to be significantly associated with SLE (OR_int=1.16, P_int_all=7.7E-04 at false discovery rate<0.05). Single nuclear polymorphism rs2222631 was found associated with SLE with genome-wide significance (P_all=4.5E-08, OR=0.86) and is independent of rs6804441 in CD80, whose association was reported previously. Significant correlation was observed between expression of these two genes in healthy controls and SLE cases, together with differential expression of these genes between cases and controls, observed from individuals from the Hong Kong cohort. Genetic interactions between BLK (rs13277113) and DDX6 (rs4639966), and between TNFSF4 (rs844648) and PXK (rs6445975) were also observed in both GWAS data sets. Our study represents the first genome-wide evaluation of epistasis interactions on SLE and the findings suggest interactions and independent variants may help partially explain missing heritability for complex diseases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Long working hours and skipping breakfast concomitant with late evening meals are associated with suboptimal glycemic control among young male Japanese patients with type 2 diabetes.

PubMed

Azami, Yasushi; Funakoshi, Mitsuhiko; Matsumoto, Hisashi; Ikota, Akemi; Ito, Koichi; Okimoto, Hisashi; Shimizu, Nobuaki; Tsujimura, Fumihiro; Fukuda, Hiroshi; Miyagi, Chozi; Osawa, Sayaka; Osawa, Ryo; Miura, Jiro

2018-04-17

To assess the associations of working conditions, eating habits and glycemic control among young Japanese workers with type 2 diabetes. This hospital- and clinic-based prospective study included 352 male and 126 female working patients with diabetes aged 20-40 years. Data were obtained from June to July 2012 and June to July 2013. Logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for suboptimal glycemic control (glycosylated hemoglobin level of ≥7%) obtained from June to July 2013. Multivariable logistic regression analysis showed that disease duration of ≥10 years (OR 2.43, 95% CI 1.02-5.80), glycosylated hemoglobin level of ≥7% in 2012 (OR 8.50, 95% CI 4.90-14.80), skipping breakfast and late evening meals (OR 2.50, 95% CI 1.25-5.00) and working ≥60 h/week (OR 2.92, 95% CI 1.16-7.40) were predictive of suboptimal glycemic control in male workers, whereas a glycosylated hemoglobin level of ≥7% in 2012 (OR 17.96, 95% CI 5.93-54.4), oral hyperglycemic agent therapy (OR 12.49, 95% CI 2.75-56.86) and insulin therapy (OR 11.60, 95% CI 2.35-57.63) were predictive of suboptimal glycemic control in female workers. Working ≥60 h/week and habitual skipping breakfast concomitant with late evening meals might affect the ability of young male workers with type 2 diabetes to achieve and maintain glycemic control. © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

[Physical and technical quality assurance in German breast cancer screening: progress report of the Reference Center Muenster after three years].

PubMed

Sommer, A; Girnus, R; Wendt, B; Czwoydzinski, J; Wüstenbecker, C; Heindel, W; Lenzen, H

2009-05-01

German breast cancer screening is monitored by a large physical quality assurance program. This report refers to the first experiences of the Reference Center (RC) Muenster after three years of the technical quality control of digital and analog mammography units (MU). This paper also shows whether the presently used quality assurance (QA) method is able to ensure that the MUs in the screening program are functioning without any serious problems. RC Muenster supervises 95 units (May 2008). The daily, weekly and monthly quality assurance of these units is controlled by web-based QA software named "MammoConrol" and developed by RC Muenster. The annual QA for the units must be conducted in the form of an on-site inspection by medical physics experts of the RC and is scored by an objective ranking system. The results of these QA routines were evaluated and analyzed for this paper. During the period from 3/1/2006 to 5/31/2008, 8 % of the analog systems and 1 % of the digital systems exhibited problems in the daily QA. For 9 % of the analog MUs and 17 % of the digital MUs, failures appeared in the monthly QA. In the annual control, 86.7 % of the analog units exhibited slight problems and 13.3 % had serious problems. With respect to the digital units, 12 % were without any defects, 58 % had slight problems, 27 % had serious failures and 3 % had to be reported to the responsible authorities and were temporarily shut down. The special quality control requirements for German breast cancer screening, including annual on-site checks of the units, have shown in the last three years that QA with a high monitoring standard can be ensured for a large number of decentralized MUs. The currently used QA method sufficiently ensures that the screening program is technically safe. Further studies must show whether the density and focus of the QA measures must be reconfigured.

Degradation of benzodiazepines after 120 days of EMS deployment.

PubMed

McMullan, Jason T; Jones, Elizabeth; Barnhart, Bruce; Denninghoff, Kurt; Spaite, Daniel; Zaleski, Erin; Silbergleit, Robert

2014-01-01

EMS treatment of status epilepticus improves outcomes, but the benzodiazepine best suited for EMS use is unclear, given potential high environmental temperature exposures. To describe the degradation of diazepam, lorazepam, and midazolam as a function of temperature exposure and time over 120 days of storage on active EMS units. Study boxes containing vials of diazepam, lorazepam, and midazolam were distributed to 4 active EMS units in each of 2 EMS systems in the southwestern United States during May-August 2011. The boxes logged temperature every minute and were stored in EMS units per local agency policy. Two vials of each drug were removed from each box at 30-day intervals and underwent high-performance liquid chromatography to determine drug concentration. Concentration was analyzed as mean (and 95%CI) percent of initial labeled concentration as a function of time and mean kinetic temperature (MKT). 192 samples were collected (2 samples of each drug from each of 4 units per city at 4 time-points). After 120 days, the mean relative concentration (95%CI) of diazepam was 97.0% (95.7-98.2%) and of midazolam was 99.0% (97.7-100.2%). Lorazepam experienced modest degradation by 60 days (95.6% [91.6-99.5%]) and substantial degradation at 90 days (90.3% [85.2-95.4%]) and 120 days (86.5% [80.7-92.3%]). Mean MKT was 31.6°C (95%CI 27.1-36.1). Increasing MKT was associated with greater degradation of lorazepam, but not midazolam or diazepam. Midazolam and diazepam experienced minimal degradation throughout 120 days of EMS deployment in high-heat environments. Lorazepam experienced significant degradation over 120 days and appeared especially sensitive to higher MKT exposure.

Effects of nattokinase on blood pressure: a randomized, controlled trial.

PubMed

Kim, Ji Young; Gum, Si Nae; Paik, Jean Kyung; Lim, Hyo Hee; Kim, Kyong-Chol; Ogasawara, Kazuya; Inoue, Kenichi; Park, Sungha; Jang, Yangsoo; Lee, Jong Ho

2008-08-01

The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

Evaluation and Analysis of Gas Turbine Internal Flow Restrictors.

DTIC Science & Technology

1986-08-01

Ail? 836 EVALUATION AND ANALYSIS OF GAS TURBINE INTERNAL FLd 1/2 RESTRICTORS(U) UNIVERSAL ENERGY SYSTEMS INC DAYTON ON G F HOLLE AUG 86 AFMAL-TR-86...NUMB6EftSI 5. MONITORING ORGANIZATION REPORT NUMBERISt AFWAL-TR-86- 2050 OF pEYFsM~ 1 * ORAIAIN7 NM FMNTRIG.GNZ70 Universal Energy Systems, Inc Air Force... Energy Systems, Inc. and Allison Gas Turgine Division of General Motors Corporation was sponsored by the Aeropropulsion Laboratory, United States Air

Improving Outcomes in Patients With Sepsis.

PubMed

Armen, Scott B; Freer, Carol V; Showalter, John W; Crook, Tonya; Whitener, Cynthia J; West, Cheri; Terndrup, Thomas E; Grifasi, Marissa; DeFlitch, Christopher J; Hollenbeak, Christopher S

2016-01-01

Sepsis mortality may be improved by early recognition and appropriate treatment based on evidence-based guidelines. An intervention was developed that focused on earlier identification of sepsis, early antimicrobial administration, and an educational program that was disseminated throughout all hospital units and services. There were 1331 patients with sepsis during the intervention period and 1401 patients with sepsis during the control period. After controlling for expected mortality, patients in the intervention period had 30% lower odds of dying (odds ratio = 0.70, 95% confidence interval [CI] = 0.57 to 0.84). They also had 1.07 fewer days on average in the intensive care unit (95% CI = -1.98 to -0.16), 2.15 fewer hospital days (95% CI = -3.45 to -0.86), and incurred on average $1949 less in hospital costs, although the effect on costs was not statistically significant. Continued incremental improvement and sustainment is anticipated through organizational oversight, continued education, and initiation of an automated electronic sepsis alert function. © The Author(s) 2014.

Improving Outcomes in Patients With Sepsis

PubMed Central

Armen, Scott B.; Freer, Carol V.; Showalter, John W.; Crook, Tonya; Whitener, Cynthia J.; West, Cheri; Terndrup, Thomas E.; Grifasi, Marissa; DeFlitch, Christopher J.; Hollenbeak, Christopher S.

2017-01-01

Sepsis mortality may be improved by early recognition and appropriate treatment based on evidence-based guidelines. An intervention was developed that focused on earlier identification of sepsis, early antimicrobial administration, and an educational program that was disseminated throughout all hospital units and services. There were 1331 patients with sepsis during the intervention period and 1401 patients with sepsis during the control period. After controlling for expected mortality, patients in the intervention period had 30% lower odds of dying (odds ratio = 0.70, 95% confidence interval [CI] = 0.57 to 0.84). They also had 1.07 fewer days on average in the intensive care unit (95% CI = −1.98 to −0.16), 2.15 fewer hospital days (95% CI = −3.45 to −0.86), and incurred on average $1949 less in hospital costs, although the effect on costs was not statistically significant. Continued incremental improvement and sustainment is anticipated through organizational oversight, continued education, and initiation of an automated electronic sepsis alert function. PMID:25216849

Vertebrate species introductions in the United States and its territories

USGS Publications Warehouse

Witmer, Gary W.; Fuller, Pam L.

2011-01-01

At least 1,065 introduced vertebrate species have been introduced in the United States and its territories, including at least 86 mammalian, 127 avian, 179 reptilian/amphibian, and 673 fish species. Examples in each major taxonomic group include domestic cat, small Indian mongoose, red fox, goat, pig, rabbit, rats, house mouse, gray squirrel, nutria, starling, Indian common myna, red-vented bulbul, brown treesnake, red-eared slider, brown trout, tilapia, and grass carp. We briefly review some of these species and the types of damage they cause. We then review the basic types of methods used for control or eradication of each taxonomic group, including physical, chemical, biological, and cultural methods. We discuss some of the challenges in managing these species, including issues with the use of toxicants, land access, public attitudes, and monitoring difficulties. Finally, we list some ongoing research and future research needs, including improved detection methods, improved attractants, improved barriers, improved capture methods, fertility control, and risk assessment methods.

Great Decisions '86.

ERIC Educational Resources Information Center

Hoepli, Nancy L., Ed.

Designed to initiate discussion of foreign policy decisions, this book contains an analysis of eight foreign policy issues confronting the United States in 1986. Each unit provides the background and guidelines to provide perspective to assist in understanding foreign policy crises. The units included in this issue are: (1) "How Foreign Policy Is…

Effectiveness of Haemophilus influenzae type b vaccines administered according to various schedules: systematic review and meta-analysis of observational data.

PubMed

Jackson, Charlotte; Mann, Andrea; Mangtani, Punam; Fine, Paul

2013-11-01

Conjugate vaccines against Haemophilus influenzae type b (Hib) are widely used. The full implications of Hib vaccination schedule for vaccine effectiveness (VE) are unclear. We searched the literature for observational studies reporting the effectiveness of conjugate Hib vaccines administered according to different schedules. We summarized dose-specific VE estimates, where appropriate, using random effects meta-analysis. Thirty-one eligible articles (reporting 30 studies conducted in 17 countries) were identified. Meta-analysis of case-control studies using community controls produced VE estimates against Hib meningitis of 55% (95% confidence interval: 2-80%, based on 3 studies), 96% (86-99%, 3 studies) and 96% (86-99%, 4 studies) after 1, 2 and 3 doses of vaccines other than the polyribosyl ribitol phosphate outer membrane protein vaccine. Estimates were similar using hospital controls. VE against invasive Hib disease in case-control studies was estimated as 59% (30-76%, 3 studies) and 97% (87-99%, 3 studies) for 1 and 3 doses (insufficient data were identified to estimate 2-dose VE). Point estimates from 2 studies suggested VE>90% after 1 dose of the polyribosyl ribitol phosphate outer membrane protein vaccine, but meta-analysis was not possible. Using data from 4 cohort studies, 3-dose VE was estimated as 94% (88-97%). There was some evidence that Hib vaccine was less effective when administered with acellular (rather than whole cell) pertussis vaccine. Weak evidence from 2 studies suggested that a booster confers some additional protection following full primary vaccination and may compensate for an incomplete primary series. Observational data suggest that ≥2 doses of Hib vaccine are required for high effectiveness, but do not strongly favor any particular schedule.

40 CFR 96.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 21 2011-07-01 2011-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Individual Unit Opt-ins § 96.86 Withdrawal from NOX Budget Trading Program. (a) Requesting...

40 CFR 96.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Individual Unit Opt-ins § 96.86 Withdrawal from NOX Budget Trading Program. (a) Requesting...

40 CFR 96.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Individual Unit Opt-ins § 96.86 Withdrawal from NOX Budget Trading Program. (a) Requesting...

40 CFR 97.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Individual Unit Opt-ins § 97.86 Withdrawal from NOX Budget Trading Program. (a) Requesting withdrawal. To withdraw...

40 CFR 96.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 22 2013-07-01 2013-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO 2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Individual Unit Opt-ins § 96.86 Withdrawal from NOX Budget Trading Program. (a) Requesting...

40 CFR 97.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Individual Unit Opt-ins § 97.86 Withdrawal from NOX Budget Trading Program. (a) Requesting withdrawal. To withdraw...

40 CFR 97.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 21 2014-07-01 2014-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Individual Unit Opt-ins § 97.86 Withdrawal from NOX Budget Trading Program. (a) Requesting withdrawal. To withdraw...

40 CFR 96.86 - Withdrawal from NOX Budget Trading Program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 22 2012-07-01 2012-07-01 false Withdrawal from NOX Budget Trading... PROGRAMS (CONTINUED) NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS FOR STATE IMPLEMENTATION PLANS Individual Unit Opt-ins § 96.86 Withdrawal from NOX Budget Trading Program. (a) Requesting...

40 CFR 86.001-23 - Required data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Required data. 86.001-23 Section 86...-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.001-23 Required data. Section 86.001-23 includes text... each evaporative/refueling emission family-emission control system combination and all test data that...

40 CFR 86.001-23 - Required data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Required data. 86.001-23 Section 86...-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.001-23 Required data. Section 86.001-23 includes text... each evaporative/refueling emission family-emission control system combination and all test data that...

40 CFR 86.001-23 - Required data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Required data. 86.001-23 Section 86...-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.001-23 Required data. Section 86.001-23 includes text... each evaporative/refueling emission family-emission control system combination and all test data that...

40 CFR 86.001-23 - Required data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Required data. 86.001-23 Section 86...-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.001-23 Required data. Section 86.001-23 includes text... each evaporative/refueling emission family-emission control system combination and all test data that...

Identifying Important Gaps in Randomized Controlled Trials of Adult Cardiac Arrest Treatments: A Systematic Review of the Published Literature.

PubMed

Sinha, Shashank S; Sukul, Devraj; Lazarus, John J; Polavarapu, Vivek; Chan, Paul S; Neumar, Robert W; Nallamothu, Brahmajee K

2016-11-01

Cardiac arrest is a major public health concern worldwide. The extent and types of randomized controlled trials (RCT)-our most reliable source of clinical evidence-conducted in these high-risk patients over recent years are largely unknown. We performed a systematic review, identifying all RCTs published in PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library from 1995 to 2014 that focused on the acute treatment of nontraumatic cardiac arrest in adults. We then extracted data on the setting of study populations, types and timing of interventions studied, risk of bias, outcomes reported, and how these factors have changed over time. Over this 20-year period, 92 RCTs were published containing 64 309 patients (median, 225.5 per trial). Of these, 81 RCTs (88.0%) involved out-of-hospital cardiac arrest, whereas 4 (4.3%) involved in-hospital cardiac arrest and 7 (7.6%) included both. Eighteen RCTs (19.6%) were performed in the United States, 68 (73.9%) were performed outside the United States, and 6 (6.5%) were performed in both settings. Thirty-eight RCTs (41.3%) evaluated drug therapy, 39 (42.4%) evaluated device therapy, and 15 (16.3%) evaluated protocol improvements. Seventy-four RCTs (80.4%) examined interventions during the cardiac arrest, 15 (16.3%) examined post cardiac arrest treatment, and 3 (3.3%) studied both. Overall, reporting of the risk of bias was limited. The most common outcome reported was return of spontaneous circulation: 86 (93.5%) with only 22 (23.9%) reporting survival beyond 6 months. Fifty-three RCTs (57.6%) reported global ordinal outcomes, whereas 15 (16.3%) reported quality-of-life. RCTs in the past 5 years were more likely to be focused on protocol improvements and postcardiac arrest care. Important gaps in RCTs of cardiac arrest treatments exist, especially those examining in-hospital cardiac arrest, protocol improvement, postcardiac arrest care, and long-term or quality-of-life outcomes. © 2016 American Heart Association, Inc.

Disparities in cancer screening by occupational characteristics.

PubMed

Fedewa, Stacey A; Sauer, Ann Goding; DeSantis, Carol; Siegel, Rebecca L; Jemal, Ahmedin

2017-12-01

Cancer screening patterns according to occupation characteristics in the United States are not well known, but could be used to help inform cancer control efforts. We examined cervical (CC), breast (BC) and colorectal cancer (CRC) screening prevalence and prevalence ratios (PR) by occupational characteristics in 2010, 2013 and 2015 National Health Interview Surveys (NHIS) among eligible US workers (CC women 21-65years; n=20,997), (BC women ≥40years; n=14,258) and (CRC men and women ≥50years; n=17,333). Cervical, breast and colorectal cancer screening prevalence among US workers was 84.0%, 68.9%, and 56.8%, respectively. Unadjusted prevalence ratios for cervical (PR=0.92, 95%CI 0.90, 0.94), breast (PR=0.86, 95%CI 0.83, 0.90) and colorectal cancer screening (PR=0.83, 95%CI 0.80, 0.87) were lower among workers in small (<25 employees) compared to large organizations (≥500 employees). People in food service, construction, production, and sales occupations were 13-26%, 17-28% and 9-30% less likely to be up to date with cervical, breast, and colorectal cancer screening, respectively, compared to healthcare professionals. Adjustment for socioeconomic factors and insurance status eliminated most associations. Disparities in cancer screening by occupational characteristics were mostly attributed to lower socioeconomic status and lack of insurance. These findings underscore the need for innovative public health strategies to improve cancer screening in vulnerable populations. Copyright © 2017 Elsevier Inc. All rights reserved.

86. Shock absorber, top of launch control center, southeast corner ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. Shock absorber, top of launch control center, southeast corner - Ellsworth Air Force Base, Delta Flight, Launch Control Facility, County Road CS23A, North of Exit 127, Interior, Jackson County, SD

40 CFR 86.1826-01 - Assigned deterioration factors for small volume manufacturers and small volume test groups.

Code of Federal Regulations, 2012 CFR

2012-07-01

... durability groups) that is equipped with unproven emission control systems. (v) The manufacturer must... small volume manufacturers and small volume test groups. 86.1826-01 Section 86.1826-01 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW...

40 CFR 86.1826-01 - Assigned deterioration factors for small volume manufacturers and small volume test groups.

Code of Federal Regulations, 2013 CFR

2013-07-01

... durability groups) that is equipped with unproven emission control systems. (v) The manufacturer must... small volume manufacturers and small volume test groups. 86.1826-01 Section 86.1826-01 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW...

40 CFR 86.1826-01 - Assigned deterioration factors for small volume manufacturers and small volume test groups.

Code of Federal Regulations, 2011 CFR

2011-07-01

... durability groups) that is equipped with unproven emission control systems. (v) The manufacturer must... small volume manufacturers and small volume test groups. 86.1826-01 Section 86.1826-01 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW...

40 CFR 86.1826-01 - Assigned deterioration factors for small volume manufacturers and small volume test groups.

Code of Federal Regulations, 2010 CFR

2010-07-01

... durability groups) that is equipped with unproven emission control systems. (v) The manufacturer must... small volume manufacturers and small volume test groups. 86.1826-01 Section 86.1826-01 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW...

Calibration of amino acid racemization (AAR) kinetics in United States mid-Atlantic Coastal Plain Quaternary mollusks using 87Sr/ 86Sr analyses: Evaluation of kinetic models and estimation of regional Late Pleistocene temperature history

USGS Publications Warehouse

Wehmiller, J.F.; Harris, W.B.; Boutin, B.S.; Farrell, K.M.

2012-01-01

The use of amino acid racemization (AAR) for estimating ages of Quaternary fossils usually requires a combination of kinetic and effective temperature modeling or independent age calibration of analyzed samples. Because of limited availability of calibration samples, age estimates are often based on model extrapolations from single calibration points over wide ranges of D/L values. Here we present paired AAR and 87Sr/ 86Sr results for Pleistocene mollusks from the North Carolina Coastal Plain, USA. 87Sr/ 86Sr age estimates, derived from the lookup table of McArthur et al. [McArthur, J.M., Howarth, R.J., Bailey, T.R., 2001. Strontium isotopic stratigraphy: LOWESS version 3: best fit to the marine Sr-isotopic curve for 0-509 Ma and accompanying Look-up table for deriving numerical age. Journal of Geology 109, 155-169], provide independent age calibration over the full range of amino acid D/L values, thereby allowing comparisons of alternative kinetic models for seven amino acids. The often-used parabolic kinetic model is found to be insufficient to explain the pattern of racemization, although the kinetic pathways for valine racemization and isoleucine epimerization can be closely approximated with this function. Logarithmic and power law regressions more accurately represent the racemization pathways for all amino acids. The reliability of a non-linear model for leucine racemization, developed and refined over the past 20 years, is confirmed by the 87Sr/ 86Sr age results. This age model indicates that the subsurface record (up to 80m thick) of the North Carolina Coastal Plain spans the entire Quaternary, back to ???2.5Ma. The calibrated kinetics derived from this age model yield an estimate of the effective temperature for the study region of 11??2??C., from which we estimate full glacial (Last Glacial Maximum - LGM) temperatures for the region on the order of 7-10??C cooler than present. These temperatures compare favorably with independent paleoclimate information for the region. ?? 2011 Elsevier B.V.

Development of a Catalytic Combustor for Aircraft Gas Turbine Engines.

DTIC Science & Technology

1976-09-22

80 VI. DESIGN OF 7.6 CI CIANETE COMBUSTORS . . . . . . . . . . . 86 1. Design and Fabrication of CombusLors for Large Scale T est in...obtained for this program included round holes of different diameters, squares, rectangles, triangles, and other more complex hollow configurations

ENGINEERING DEVELOPMENT UNIT SOLAR SAIL

NASA Image and Video Library

2016-01-13

TIFFANY LOCKETT OVERSEES THE HALF SCALE (36 SQUARE METERS) ENGINEERING DEVELOPMENT UNIT (EDU) SOLAR SAIL DEPLOYMENT DEMONSTRATION IN PREPARATION FOR FULL SCALE EDU (86 SQUARE METERS) DEPLOYMENT IN APRIL, 2016. DETAILS OF RIPS AND HOLES IN SOLAR SAIL FABRIC.

APOLLO I: Anticoagulation control in atrial fibrillation.

PubMed

Pinho-Costa, Luís; Moreira, Sónia; Azevedo, Cristiana; Azevedo, Pedro; Castro, Elisabete; Sousa, Hélder; Melo, Miguel

2015-05-01

Anticoagulation control as assessed by time in therapeutic range (TTR) correlates positively with the safety and efficacy of thromboprophylaxis in atrial fibrillation. We set out to assess TTR in our unit and to investigate determinants of better control. This was a case series study of atrial fibrillation patients anticoagulated with warfarin or acenocoumarol at the Family Health Unit of Fânzeres. Sociodemographic and clinical data were collected and TTR was calculated by the Rosendaal method, based on international normalized ratio tests performed in external laboratories in the preceding six months. SPSS 21.0 was used for the statistical analysis, with descriptive statistics, Spearman's correlation, and the Mann-Whitney U and Kruskal-Wallis tests. Of the 106 eligible patients, 70% participated in the study. Median TTR was 65.3% (P25=48.3%, P75=86.8%). We found a positive association between this variable and duration of atrial fibrillation (ρ=0.477, p<0.001, r(2)=0.116) and with duration of anticoagulation (ρ=0.5, p<0.001, r(2)=0.087). No association was found with age, gender, educational level or existence of a caregiver (p>0.05). Median TTR in our unit is similar to that in southern European countries and close to the good control threshold (70%) proposed by the European Society of Cardiology. The duration of atrial fibrillation and of anticoagulation explains only a small part of the measure's variability. Other determinants of anticoagulation control must be investigated in future studies and comparative studies should be carried out in family health units monitoring anticoagulation on the premises. Copyright © 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

Participation in a National Lifestyle Change Program is associated with improved diabetes Control outcomes.

PubMed

Jackson, Sandra L; Staimez, Lisa R; Safo, Sandra; Long, Qi; Rhee, Mary K; Cunningham, Solveig A; Olson, Darin E; Tomolo, Anne M; Ramakrishnan, Usha; Narayan, Venkat K M; Phillips, Lawrence S

2017-09-01

Clinical trials show lifestyle change programs are beneficial, yet large-scale, successful translation of these programs is scarce. We investigated the association between participation in the largest U.S. lifestyle change program, MOVE!, and diabetes control outcomes. This longitudinal, retrospective cohort study used Veterans Health Administration databases of patients with diabetes who participated in MOVE! between 2005 and 2012, or met eligibility criteria (BMI ≥25kg/m 2 ) but did not participate. Main outcomes were diabetic eye disease, renal disease, and medication intensification. There were 400,170 eligible patients with diabetes, including 87,366 (22%) MOVE! Included patients were 96% male, 77% white, with mean age 58years and BMI 34kg/m 2 . Controlling for baseline measurements and age, race, sex, BMI, and antidiabetes medications, MOVE! participants had lower body weight (-0.6kg), random plasma glucose (-2.8mg/dL), and HbA1c (-0.1%) at 12months compared to nonparticipants (each p<0.001). In multivariable Cox models, MOVE! participants had lower incidence of eye disease (hazard ratio 0.80, 95% CI 0.75-0.84) and renal disease (HR 0.89, 95% CI 0.86-0.92) and reduced medication intensification (HR 0.82, 95% CI 0.80-0.84). If able to overcome participation challenges, lifestyle change programs in U.S. health systems may improve health among the growing patient population with diabetes. Published by Elsevier Inc.

Reduction of intra-hospital transport time using the easy tube arrange device.

PubMed

Joo, Ki Hyuk; Yoo, In Sool; Lee, Jinwoong; Kim, Seung Whan; Ryu, Seung; You, Yeon Ho; Cho, Yong Chul; Jeong, Woon Jun; Ahn, Byung Jun; Cho, Sung Uk

2016-06-01

Critically ill patients sometimes require transport to another location. Longer intra-hospital transport time increases the risk of hemodynamic instability and associated complications. Therefore, reducing intra-hospital transport time is critical. Our objective was to evaluate whether or not a new device the easy tube arrange device (ETAD) has the potential to reduce intra-hospital transport time of critically ill patients. We enrolled volunteers for this prospective randomized controlled study. Each participant arranged four, five, and six fluid tubings, monitoring lines, and therapeutic equipment on a cardiopulmonary resuscitation training mannequin (Resusci Anne). The time required to arrange the fluid tubings for intra-hospital transport using two different methods was evaluated. The median time to arrange four, five, and six fluid tubings was 86.00 (76.50 to 98.50), 96.00 (86.00 to 113.00), and 115.50 (93.00 to 130.75) seconds, respectively, using the conventional method and 60.50 (52.50 to 72.75), 69.00 (57.75 to 80.80), and 72.50 (64.75 to 90.50) seconds using the ETAD (all P<0.001). The total duration (for preparing the basic setting and organizing before and after the transport) was 280.00 (268.75 to 293.00), 315.50 (304.75 to 330.75), and 338.00 (319.50 to 360.25) seconds for four, five, and six fluid tubings, respectively, using the conventional method and 274.50 (261.75 to 289.25), 288.00 (271.75 to 298.25), and 301.00 (284.50 to 310.75) seconds, respectively, using the new method (P=0.024, P<0.001, and P<0.001, respectively). The ETAD was convenient to use, reduced the time to arrange medical tubings, and is expected to assist medical staff during intra-hospital transport.

Implementation and evaluation of an automated dispensing system.

PubMed

Schwarz, H O; Brodowy, B A

1995-04-15

An institution's experience in replacing a traditional unit dose cassette-exchange system with an automated dispensing system is described. A 24-hour unit dose cassette-exchange system was replaced with an automated dispensing system (Pyxis's Medstation Rx) on a 36-bed cardiovascular surgery unit and an 8-bed cardiovascular intensive care unit. Significantly fewer missing doses were reported after Medstation Rx was implemented. No conclusions could be made about the impact of the system on the reporting of medication errors. The time savings for pharmacy associated with the filling, checking, and delivery of new medication orders equated to about 0.5 full-time equivalent (FTE). Medstation Rx also saved substantial nursing time for acquisition of controlled substances and for controlled-substance inventory taking at shift changes. A financial analysis showed that Medstation Rx could save the institution about $1 million over five years if all personnel time savings could be translated into FTE reductions. The automated system was given high marks by the nurses in a survey; 80% wanted to keep the system on their unit. Pilot implementation of an automated dispensing system improved the efficiency of drug distribution over that of the traditional unit dose cassette-exchange system.

Safety, efficacy and clinical generalization of the STAR protocol: a retrospective analysis.

PubMed

Stewart, Kent W; Pretty, Christopher G; Tomlinson, Hamish; Thomas, Felicity L; Homlok, József; Noémi, Szabó Némedi; Illyés, Attila; Shaw, Geoffrey M; Benyó, Balázs; Chase, J Geoffrey

2016-12-01

The changes in metabolic pathways and metabolites due to critical illness result in a highly complex and dynamic metabolic state, making safe, effective management of hyperglycemia and hypoglycemia difficult. In addition, clinical practices can vary significantly, thus making GC protocols difficult to generalize across units.The aim of this study was to provide a retrospective analysis of the safety, performance and workload of the stochastic targeted (STAR) glycemic control (GC) protocol to demonstrate that patient-specific, safe, effective GC is possible with the STAR protocol and that it is also generalizable across/over different units and clinical practices. Retrospective analysis of STAR GC in the Christchurch Hospital Intensive Care Unit (ICU), New Zealand (267 patients), and the Gyula Hospital, Hungary (47 patients), is analyzed (2011-2015). STAR Christchurch (BG target 4.4-8.0 mmol/L) is also compared to the Specialized Relative Insulin and Nutrition Tables (SPRINT) protocol (BG target 4.4-6.1 mmol/L) implemented in the Christchurch Hospital ICU, New Zealand (292 patients, 2005-2007). Cohort mortality, effectiveness and safety of glycemic control and nutrition delivered are compared using nonparametric statistics. Both STAR implementations and SPRINT resulted in over 86 % of time per episode in the blood glucose (BG) band of 4.4-8.0 mmol/L. Patients treated using STAR in Christchurch ICU spent 36.7 % less time on protocol and were fed significantly more than those treated with SPRINT (73 vs. 86 % of caloric target). The results from STAR in both Christchurch and Gyula were very similar, with the BG distributions being almost identical. STAR provided safe GC with very few patients experiencing severe hypoglycemia (BG < 2.2 mmol/L, <5 patients, 1.5 %). STAR outperformed its predecessor, SPRINT, by providing higher nutrition and equally safe, effective control for all the days of patient stay, while lowering the number of measurements and interventions required. The STAR protocol has the ability to deliver high performance and high safety across patient types, time, clinical practice culture (Christchurch and Gyula) and clinical resources.

Survival of patients with gastric lymphoma in Germany and in the United States.

PubMed

Castro, Felipe A; Jansen, Lina; Krilaviciute, Agne; Katalinic, Alexander; Pulte, Dianne; Sirri, Eunice; Ressing, Meike; Holleczek, Bernd; Luttmann, Sabine; Brenner, Hermann

2015-10-01

This study aims to examine survival for gastric lymphomas and its main subtypes, mucosa-associated lymphoid tissue lymphoma (MALT), and diffuse large B-cell lymphoma (DLBCL), in Germany and in the United States. Data for patients diagnosed in 1997-2010 were used from 10 population-based German cancer registries and compared to the data from the US Surveillance, Epidemiology and End Results (SEER) 13 registries database. Patients age 15-74 diagnosed with gastric lymphomas were included in the analysis. Period analysis and modeled period analysis were used to estimate 5-year and 10-year relative survival (RS) in 2002-2010 and survival trends from 2002-2004 to 2008-2010. Overall, the database included 1534 and 2688 patients diagnosed with gastric lymphoma in 1997-2010 in Germany and in the United States, respectively. Survival was substantially higher for MALT (5-year and 10-year RS: 89.0% and 80.9% in Germany, 93.8% and 86.8% in the United States) than for DLBCL (67.5% and 59.2% in Germany, and 65.3% and 54.7% in the United States) in 2002-2010. Survival was slightly higher among female patients and decreased by age for gastric lymphomas combined and its main subtypes. A slight, nonsignificant, increase in the 5-year RS for gastric lymphomas combined was observed in Germany and the United States, with increases in 5-year RS between 2002-2004 and 2008-2010 from 77.1% to 81.0% and from 77.3% to 82.0%, respectively. Five-year RS of MALT exceeded 90% in 2008-2010 in both countries. Five-year RS of MALT meanwhile exceeds 90% in both Germany and the United States, but DLBCL has remained below 70% in both countries. © 2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

Improving teamwork: impact of structured interdisciplinary rounds on a hospitalist unit.

PubMed

O'Leary, Kevin J; Haviley, Corinne; Slade, Maureen E; Shah, Hiren M; Lee, Jungwha; Williams, Mark V

2011-02-01

Effective collaboration and teamwork is essential in providing safe and effective care. Research reveals deficiencies in teamwork on medical units involving hospitalists. The aim of this study was to assess the impact of an intervention, Structured Inter-Disciplinary Rounds (SIDR), on nurses' ratings of collaboration and teamwork. The study was a controlled trial involving an intervention and control hospitalist unit. The intervention, SIDR, combined a structured format for communication with a forum for regular interdisciplinary meetings. We asked nurses to rate the quality of communication and collaboration with hospitalists using a 5-point ordinal scale. We also assessed teamwork and safety climate using a validated instrument. Multivariable regression analyses were used to assess the impact on length of stay (LOS) and cost using both a concurrent and historic control. A total of 49 of 58 (84%) nurses completed surveys. A larger percentage of nurses rated the quality of communication and collaboration with hospitalists as high or very high on the intervention unit compared to the control unit (80% vs. 54%; P = 0.05). Nurses also rated the teamwork and safety climate significantly higher on the intervention unit (P = 0.008 and P = 0.03 for teamwork and safety climate, respectively). Multivariable analyses demonstrated no difference in the adjusted LOS and an inconsistent effect on cost. SIDR had a positive effect on nurses' ratings of collaboration and teamwork on a hospitalist unit, yet no impact on LOS and cost. Further study is required to assess the impact of SIDR on patient safety measures. Copyright © 2010 Society of Hospital Medicine.

40 CFR 86.1823-08 - Durability demonstration procedures for exhaust emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES (CONTINUED) General Compliance Provisions for Control of Air Pollution From New and In... volume test groups may optionally meet the requirements of §§ 86.1838-01 and 86.1826-01 in lieu of the...

45 CFR 2543.86 - Clean Air Act and the Federal Water Pollution Control Act.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 4 2012-10-01 2012-10-01 false Clean Air Act and the Federal Water Pollution Control Act. 2543.86 Section 2543.86 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT...

45 CFR 2543.86 - Clean Air Act and the Federal Water Pollution Control Act.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 4 2013-10-01 2013-10-01 false Clean Air Act and the Federal Water Pollution Control Act. 2543.86 Section 2543.86 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, AND OTHER NON-PROFIT...

Regional distribution of Paenibacillus larvae subspecies larvae, the causative organism of American foulbrood, in honey bee colonies of the Western United States.

PubMed

Eischen, Frank A; Graham, R Henry; Cox, Robert

2005-08-01

We examined honey bee, Apis mellifera L., colonies pollinating almonds in California during February 2003 for Paenibacillus larvae subsp. Larvae, the causative organism of the virulent brood disease American foulbrood. Colonies originating from the Rocky Mountain area and California had significantly higher numbers (P < 0.05) of bacterial colony-forming units (CFUs) (408 and 324 per 30 adult bees, respectively) than colonies from the upper Midwest (1.28). Colonies from the northwestern, central, and southwestern United States had intermediate CFU or bacterial colony levels. Operations positive for P. larvae larvae were relatively uniform at approximately 70-80%, and no regional significant differences were found. Percentages of colonies with high CFUs (> or = 400 per 30 bees) differed significantly, with those from the Rocky Mountain region having 8.73% compared with those of the upper Midwest with 0%. The significance of CFU levels was evaluated by inoculating healthy colonies with diseased immatures and sampling adult bees. The number of CFUs detected per diseased immature was conservatively estimated to be approximately 399 CFUs per 30 adult bees. We defined this spore level as 1 disease equivalent. Based on this, 3.86% colonies in our survey had 1 or more disease equivalent number of P. larvae larvae CFUs. Operations with high P. larvae larvae spore levels in their colonies will likely observe American foulbrood if prophylaxis is not practiced diligently.

Temperature-(208-318 K) and pressure-(18-696 Torr) dependent rate coefficients for the reaction between OH and HNO3

NASA Astrophysics Data System (ADS)

Dulitz, Katrin; Amedro, Damien; Dillon, Terry J.; Pozzer, Andrea; Crowley, John N.

2018-02-01

Rate coefficients (k5) for the title reaction were obtained using pulsed laser photolytic generation of OH coupled to its detection by laser-induced fluorescence (PLP-LIF). More than 80 determinations of k5 were carried out in nitrogen or air bath gas at various temperatures and pressures. The accuracy of the rate coefficients obtained was enhanced by in situ measurement of the concentrations of both HNO3 reactant and NO2 impurity. The rate coefficients show both temperature and pressure dependence with a rapid increase in k5 at low temperatures. The pressure dependence was weak at room temperature but increased significantly at low temperatures. The entire data set was combined with selected literature values of k5 and parameterised using a combination of pressure-dependent and -independent terms to give an expression that covers the relevant pressure and temperature range for the atmosphere. A global model, using the new parameterisation for k5 rather than those presently accepted, indicated small but significant latitude- and altitude-dependent changes in the HNO3 / NOx ratio of between -6 and +6 %. Effective HNO3 absorption cross sections (184.95 and 213.86 nm, units of cm2 molecule-1) were obtained as part of this work: σ213.86 = 4.52-0.12+0.23 × 10-19 and σ184.95 = 1.61-0.04+0.08 × 10-17.

A Web-Based Education Program for Colorectal Lesion Diagnosis with Narrow Band Imaging Classification.

PubMed

Aihara, Hiroyuki; Kumar, Nitin; Thompson, Christopher C

2018-04-19

An education system for narrow band imaging (NBI) interpretation requires sufficient exposure to key features. However, access to didactic lectures by experienced teachers is limited in the United States. To develop and assess the effectiveness of a colorectal lesion identification tutorial. In the image analysis pretest, subjects including 9 experts and 8 trainees interpreted 50 white light (WL) and 50 NBI images of colorectal lesions. Results were not reviewed with subjects. Trainees then participated in an online tutorial emphasizing NBI interpretation in colorectal lesion analysis. A post-test was administered and diagnostic yields were compared to pre-education diagnostic yields. Under the NBI mode, experts showed higher diagnostic yields (sensitivity 91.5% [87.3-94.4], specificity 90.6% [85.1-94.2], and accuracy 91.1% [88.5-93.7] with substantial interobserver agreement [κ value 0.71]) compared to trainees (sensitivity 89.6% [84.8-93.0], specificity 80.6% [73.5-86.3], and accuracy 86.0% [82.6-89.2], with substantial interobserver agreement [κ value 0.69]). The online tutorial improved the diagnostic yields of trainees to the equivalent level of experts (sensitivity 94.1% [90.0-96.6], specificity 89.0% [83.0-93.2], and accuracy 92.0% [89.3-94.7], p < 0.001 with substantial interobserver agreement [κ value 0.78]). This short, online tutorial improved diagnostic performance and interobserver agreement. © 2018 S. Karger AG, Basel.

ERIC First Analysis: Water Resources; 1985-86 National High School Debate Resolutions.

ERIC Educational Resources Information Center

Wagner, David L.; Fraleigh, Douglas

Designed to serve as a framework from which high school debate students, coaches, and judges can evaluate the issues, arguments and evidence present in the availability and quality of water resources in the United States, this booklet provides guidelines for research on the 1985-86 debate resolutions selected by the National Federation of State…

Park West High School Vocational and High School Equivalency Bilingual Program 1985-86. OEA Evaluation Section Report.

ERIC Educational Resources Information Center

New York City Board of Education, Brooklyn, NY. Office of Educational Evaluation.

The Vocational and High School Equivalency Bilingual Program helped students with limited English proficiency develop their English language skills enough to enable them to participate effectively in mainstream classes and compete successfully in the United States labor market. During 1985-86 the program provided English as a second language and…

Production of Omega-3 Fatty Acid Ethyl Esters from Menhaden Oil Using Proteus vulgaris Lipase-Mediated One-Step Transesterification and Urea Complexation.

PubMed

Kim, Soo-Jin; Kim, Hyung Kwoun

2016-05-01

An organic solvent-stable lipase from Proteus vulgaris K80 was used to produce the omega-3 polyunsaturated fatty acid ethyl esters (ω-3 PUFA EEs). First, the lyophilized recombinant lipase K80 (LyoK80) was used to perform the transesterification reaction of menhaden oil and ethanol. LyoK80 produced the ω-3 PUFA EEs with a conversion yield of 82 % in the presence of 20 % water content via a three-step ethanol-feeding process; however, in a non-aqueous condition, LyoK80 produced only a slight amount of the ω-3 PUFA EEs. To enhance its reaction properties, the lipase K80 was immobilized on a hydrophobic bead to derive ImmK80; the biochemical properties and substrate specificity of ImmK80 are similar to those of LyoK80. ImmK80 was then used to produce ω-3 PUFA EEs in accordance with the same transesterification reaction. Unlike LyoK80, ImmK80 achieved a high ω-3 PUFA EE conversion yield of 86 % under a non-aqueous system via a one-step ethanol-feeding reaction. The ω-3 PUFA EEs were purified up to 92 % using a urea complexation method.

Producibility Engineering and Planning (PEP)

DTIC Science & Technology

1977-01-01

Materiel System, May 1976. c. Cesare Raimondi, "Estimating Drafting Time - Art , Science , Guess- work", Machine Design, 7 September 1972. d. Current Wage...Comprehensive 8 16 24 32 40 86 45 70 90 80 1/ Cesare Raimondi, "Estimating Drafting Time- Art , Science , Guesswork," Machine Design, September

Effect of low-dose spironolactone on resistant hypertension in type 2 diabetes mellitus: a randomized controlled trial in a sub-Saharan African population.

PubMed

Djoumessi, Romance Nguetse; Noubiap, Jean Jacques N; Kaze, Francois Folefack; Essouma, Mickael; Menanga, Alain Patrick; Kengne, Andre Pascal; Mbanya, Jean Claude; Sobngwi, Eugene

2016-03-23

Low-dose spironolactone has been proven to be effective for resistant hypertension in the general population, but this has yet to be confirmed in type 2 diabetic (T2DM) patients. We assessed the efficacy of a low-dose spironolactone on resistant hypertension in a sub-Saharan African population of T2DM patients from Cameroon. This was a four-week single blinded randomized controlled trial in 17 subjects presenting with resistant hypertension in specialized diabetes care units in Cameroon. They were randomly assigned to treatment with a daily 25 mg of spironolactone (n = 9) or to an alternative antihypertensive regimen (n = 8), on top of any ongoing regimen and prevailing lifestyle prescriptions. They were seen at the start of the treatment, then 2 and 4 weeks later. The primary outcome was change in office and self-measured blood pressure (BP) during follow-up, and secondary outcomes were changes in serum potassium, sodium, and creatinine levels. Compared with alternative treatment, low-dose spironolactone was associated with significant decrease in office systolic BP (-33 vs. -14 mmHg; p = 0.024), and in diastolic BP (-14 vs. -5 mmHg; p = 0.006). After 1 month of spironolactone, all the patients were controlled based on BP below 130/80 mmHg, with significant office BP reduction from 158 ± 17/86 ± 11 to 125 ± 11/72 ± 8, vs. 158 ± 8/94 ± 8 to 144 ± 17/89 ± 12 mmHg in the alternative treatment group. There was no significant variation in sodium and creatinine levels in both groups, but a mild increase of potassium levels in the spironolactone group. Add-on low-dose spironolactone was effective in reducing BP to optimal levels in T2DM Cameroonian patients despite mild increase in serum potassium. Trial registration ClinicalTrials.gov Identifier NCT02426099. Date of registration April 2015.

Immunisation with recombinant proteins subolesin and Bm86 for the control of Dermanyssus gallinae in poultry.

PubMed

Harrington, David; Canales, Mario; de la Fuente, José; de Luna, Carlos; Robinson, Karen; Guy, Jonathan; Sparagano, Olivier

2009-06-19

Dermanyssus gallinae has a worldwide distribution and is considered to be the most serious and economically significant ectoparasite affecting egg-laying poultry in Europe. Recombinant Bm86 and subolesin proteins derived from Boophilus microplus ticks and Aedes albopictus mosquitoes were used to immunise poultry in an attempt to control D. gallinaein vitro. Immunisation with subolesin and Bm86 stimulated different profiles of IgY response, whilst Bm86 but not subolesin was recognized by IgY on western blots. Orthologues for Bm86 were not found in D. gallinae by PCR, but a 150 bp fragment aligned with mammalian akirin 1 and a 300 bp fragment aligned with Amblyomma hebraeum were amplified by subolesin PCR. D. gallinae mortality after feeding was 35.1% higher (P=0.009) in the Subolesin group and 23% higher (not significant) in the Bm86 compared to the Control group. Thus it can be concluded that immunisation with recombinant subolesin can stimulate a protective response in laying hens against D. gallinae.

40 CFR 763.86 - Sampling.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Sampling. 763.86 Section 763.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.86 Sampling. (a) Surfacing material. An accredited inspector...

40 CFR 763.86 - Sampling.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Sampling. 763.86 Section 763.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.86 Sampling. (a) Surfacing material. An accredited inspector...

40 CFR 763.86 - Sampling.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Sampling. 763.86 Section 763.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.86 Sampling. (a) Surfacing material. An accredited inspector...

40 CFR 763.86 - Sampling.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Sampling. 763.86 Section 763.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.86 Sampling. (a) Surfacing material. An accredited inspector...

40 CFR 763.86 - Sampling.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sampling. 763.86 Section 763.86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT ASBESTOS Asbestos-Containing Materials in Schools § 763.86 Sampling. (a) Surfacing material. An accredited inspector...

Alternative Method for the Thermospheric Atomic Oxygen Density Determination

NASA Technical Reports Server (NTRS)

Bennett, A. C.; Omidvar, K.; Atlas, Robert (Technical Monitor)

2001-01-01

Atomic oxygen density in the upper thermosphere (approximately 300 km) can be calculated using ground based incoherent scatter radar and Fabry-Perot interferometer measurements. Burnside et al. was the first to try this method, but Buonsanto et al. provided an extensive treatment of the method in 1997. This paper further examines the method using 46 nights of data collected over six years and the latest information on the oxygen collision frequency. The method is compared with the MSIS (Mass Spectrometer Incoherent Scatter)-86 atomic oxygen prediction values, which are based upon in situ rocket born and satellite measurements from the 70s to the mid-80s. In general, the method supports the MSIS-86 model, but indicates several areas of discrepancy. Furthermore, no direct correlation is found between the geomagnetic conditions and the difference between the method and MSIS-86 predictions.

Polychlorinated biphenyls in fly ashes collected from five coal-fired power plants in North China

NASA Astrophysics Data System (ADS)

Li, Zhiyong; Li, Xu; Ma, Huiqiao; Fan, Lin

2017-01-01

The 5 coal fly ash samples (CFA) were systematically collected from 5 coal-fired power plants (CFPPs) in North China for analysis of 86 PCB congeners. The predominant PCB congeners were PCB-6, -4/10, -28, -18, -19 and -16/32, which belonged to lighter molecular weight (LMW) congeners. The Σ86PCBs for 5 CFPPs ranged from 10.93 to 32.06 ng/g with the mean value as 16.01 ng/g. The PCBs in CFA were dominated by LMW-PCBs with 2-, 3- and 4-Cl PCBs contributed 34.80%, 39.18% and 9.21% to the Σ86PCBs. The TEQ concentrations for 5 CFPPs was 42.54 pg/g higher than 4 pg/g designed by Canada for soil quality, indicated the using of CFA as soil amendment should be cautioned.

Glucocorticoid Antagonism by Endotoxin: Biological Effects during Stress and Basis for Inhibition of Phosphoenolpyruvate Carboxykinase

DTIC Science & Technology

1985-08-01

measurements of PEPCK by catalytic activity (carboyylation) and antigenicity CELISA) ...... 80 discussion. . .................................... 86a...histamine, LPS, or histamine releasor 2agent, known as 48/ 80 , produce increased portal venous pressure with subsequent pooling of blood in the hepato...was washed 4 times for 10 minutes each time in 250 ml wash buff’r (PBS-TW: 3.1S M NaCl in 0.01 M Na1HPO/ NaHPO, pH 7.2, containing 0.3% Tween 20) at

Lipase production by Penicillium restrictum using solid waste of industrial babassu oil production as substrate.

PubMed

Palma, M B; Pinto, A L; Gombert, A K; Seitz, K H; Kivatinitz, S C; Castilho, L R; Freire, D M

2000-01-01

Lipase, protease, and amylase production by Penicillium restrictum in solid-state fermentation was investigated. The basal medium was an industrial waste of babassu oil (Orbignya oleifera) production. It was enriched with peptone, olive oil, and Tween-80. The supplementation positively influenced both enzyme production and fungal growth. Media enriched with Tween-80 provided the highest protease activity (8.6 U/g), whereas those enriched with peptone and olive oil led to the highest lipase (27.8 U/g) and amylase (31.8 U/g) activities, respectively.

Inventory Optimization of USMC Uniforms Through Reverse Logistics

DTIC Science & Technology

2016-05-01

Blouse, Desert, MCCUU wiPermethrin 3 $ 38.86 $ 116.58 8415-01-527-1430 03092 Blouse, Woodland, MCCUU wiPermethrin 2 $ 38.90 $ 77.80 8430-01-591· 1103 ...1 $ 11.66 $ 11.66 8455-01-503- 1103 10054 Clasp, Necktie, Gold Plated 1 $ 1.46 $ 1.46 8405-01-279-5579 02049 Coat, Man’s PolyiWool Gabardne, Green. w...Woodland, MCCUU wiPermethrin 2 $ 38.90 $ 77.80 8430-01-591· 1103 04094 Boot, Rugged All Terrain (RAT), Hot Weather $ 141.70 $ 141.70 8430-01-563-6897 03544

40 CFR 432.12 - Effluent limitations attainable by the application of the best practicable control technology...

Code of Federal Regulations, 2012 CFR

2012-07-01

... units (CFU) per 100 mL at any time. 3 No maximum monthly average limitation. 4 May be measured as hexane... following effluent limitation for ammonia (as N): Effluent Limitations [BPT] Regulatedparameter Maximum daily 1 Maximum monthly avg. 1 Ammonia (as N) 8.0 4.0 1 mg/L (ppm). (2) In the case of process...

40 CFR 432.12 - Effluent limitations attainable by the application of the best practicable control technology...

Code of Federal Regulations, 2013 CFR

2013-07-01

... units (CFU) per 100 mL at any time. 3 No maximum monthly average limitation. 4 May be measured as hexane... following effluent limitation for ammonia (as N): Effluent Limitations [BPT] Regulatedparameter Maximum daily 1 Maximum monthly avg. 1 Ammonia (as N) 8.0 4.0 1 mg/L (ppm). (2) In the case of process...

40 CFR 432.12 - Effluent limitations attainable by the application of the best practicable control technology...

Code of Federal Regulations, 2014 CFR

2014-07-01

... units (CFU) per 100 mL at any time. 3 No maximum monthly average limitation. 4 May be measured as hexane... following effluent limitation for ammonia (as N): Effluent Limitations [BPT] Regulatedparameter Maximum daily 1 Maximum monthly avg. 1 Ammonia (as N) 8.0 4.0 1 mg/L (ppm). (2) In the case of process...

40 CFR 432.12 - Effluent limitations attainable by the application of the best practicable control technology...

Code of Federal Regulations, 2010 CFR

2010-07-01

... units (CFU) per 100 mL at any time. 3 No maximum monthly average limitation. 4 May be measured as hexane... following effluent limitation for ammonia (as N): Effluent Limitations [BPT] Regulatedparameter Maximum daily 1 Maximum monthly avg. 1 Ammonia (as N) 8.0 4.0 1 mg/L (ppm). (2) In the case of process...

40 CFR 432.12 - Effluent limitations attainable by the application of the best practicable control technology...

Code of Federal Regulations, 2011 CFR

2011-07-01

... units (CFU) per 100 mL at any time. 3 No maximum monthly average limitation. 4 May be measured as hexane... following effluent limitation for ammonia (as N): Effluent Limitations [BPT] Regulatedparameter Maximum daily 1 Maximum monthly avg. 1 Ammonia (as N) 8.0 4.0 1 mg/L (ppm). (2) In the case of process...

76 FR 70382 - Airworthiness Directives; General Electric Company (GE) CF6-80C2B Series Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-14

... installing software version 8.2.Q1 to the engine electronic control unit (ECU), which increases the engine's... proposed AD would require the removal of the affected ECUs from service. We are proposing this AD to... software version 8.2.Q1 to the ECU, which increases the engine's margin to flameout. That AD was prompted...

A new approach to the use of α-fetoprotein as surveillance test for hepatocellular carcinoma in patients with cirrhosis

PubMed Central

Biselli, M; Conti, F; Gramenzi, A; Frigerio, M; Cucchetti, A; Fatti, G; D'Angelo, M; Dall'Agata, M; Giannini, E G; Farinati, F; Ciccarese, F; Andreone, P; Bernardi, M; Trevisani, F

2015-01-01

Background: Surveillance for hepatocellular carcinoma (HCC) is recommended in patients with cirrhosis. As α-fetoprotein (AFP) is considered a poor surveillance test, we tested the performance of its changes over time. Methods: Eighty patients were diagnosed with HCC (cases) during semiannual surveillance with ultrasonography and AFP measurement were recruited and matched for age, gender, etiology and Child-Pugh class with 160 contemporary cancer-free controls undergoing the same surveillance training group (TG). As a validation group (VG) we considered 36 subsequent patients diagnosed with HCC, matched 1 : 3 with contemporary cancer-free controls. α-Fetoprotein values at the time of HCC diagnosis (T0) and its changes over the 12 (Δ12) and 6 months (Δ6) before cancer detection were considered. Results: In both TG and VG, >80% of HCCs were found at an early stage. In TG, AFP significantly increased over time only in cases. T0 AFP and a positive Δ6 were independently associated with HCC diagnosis (odds ratio: 1.031 and 2.402, respectively). The area under the curve of T0 AFP was 0.76 and its best cutoff (BC) was 10 ng ml−1 (sensitivity 66.3%, specificity 80.6%). The combination of AFP >10 ng ml−1 or a positive Δ6 composite α-fetoprotein index (CAI) increased the sensitivity to 80% with a negative predictive value (NPV) of 86.2%. Negative predictive value rose to 99%, considering a cancer prevalence of 3%. In the VG, the AFP-BC was again 10 ng ml−1 (sensitivity 66.7%, specificity 88.9%), and CAI sensitivity was 80.6% with a NPV value of 90.5%. Conclusions: CAI achieves adequate sensitivity and NPV as a surveillance test for the early detection of HCC in cirrhosis. PMID:25314061

In Vivo Dentate Nucleus Gamma-aminobutyric Acid Concentration in Essential Tremor vs. Controls.

PubMed

Louis, Elan D; Hernandez, Nora; Dyke, Jonathan P; Ma, Ruoyun E; Dydak, Ulrike

2018-04-01

Despite its high prevalence, essential tremor (ET) is among the most poorly understood neurological diseases. The presence and extent of Purkinje cell (PC) loss in ET is the subject of controversy. PCs are a major storehouse of central nervous system gamma-aminobutyric acid (GABA), releasing GABA at the level of the dentate nucleus. It is therefore conceivable that cerebellar dentate nucleus GABA concentration could be an in vivo marker of PC number. We used in vivo 1 H magnetic resonance spectroscopy (MRS) to quantify GABA concentrations in two cerebellar volumes of interest, left and right, which included the dentate nucleus, comparing 45 ET cases to 35 age-matched controls. 1 H MRS was performed using a 3.0-T Siemens Tim Trio scanner. The MEGA-PRESS J-editing sequence was used for GABA detection in two cerebellar volumes of interest (left and right) that included the dentate nucleus. The two groups did not differ with respect to our primary outcome of GABA concentration (given in institutional units). For the right dentate nucleus, [GABA] in ET cases = 2.01 ± 0.45 and [GABA] in controls = 1.86 ± 0.53, p = 0.17. For the left dentate nucleus, [GABA] in ET cases = 1.68 ± 0.49 and [GABA] controls = 1.80 ± 0.53, p = 0.33. The controls had similar dentate nucleus [GABA] in the right vs. left dentate nucleus (p = 0.52); however, in ET cases, the value on the right was considerably higher than that on the left (p = 0.001). We did not detect a reduction in dentate nucleus GABA concentration in ET cases vs. One interpretation of the finding is that it does not support the existence of PC loss in ET; however, an alternative interpretation is the observed pattern could be due to the effects of terminal sprouting in ET (i.e., collateral sprouting from surviving PCs making up for the loss of GABA-ergic terminals from PC degeneration). Further research is needed.

Data from Controlled Metabolic Ward Studies Provide Guidance for the Determination of Status Indicators and Dietary Requirements for Magnesium.

PubMed

Nielsen, Forrest H; Johnson, Lu Ann K

2017-05-01

Determination of whether magnesium (Mg) is a nutrient of public health concern has been hindered by questionable Dietary Recommended Intakes (DRIs) and problematic status indicators that make Mg deficiency assessment formidable. Balance data obtained since 1997 indicate that the EAR and RDA for 70-kg healthy individuals are about 175 and 250 mg/day, respectively, and these DRIs decrease or increase based on body weight. These DRIs are less than those established for the USA and Canada. Urinary excretion data from tightly controlled metabolic unit balance studies indicate that urinary Mg excretion is 40 to 80 mg (1.65 to 3.29 mmol)/day when Mg intakes are <250 mg (10.28 mmol)/day, and 80 to 160 mg (3.29 to 6.58 mmol)/day when intakes are >250 mg (10.28 mmol)/day. However, changing from low to high urinary excretion with an increase in dietary intake occurs within a few days and vice versa. Thus, urinary Mg as a stand-alone status indicator would be most useful for population studies and not useful for individual status assessment. Tightly controlled metabolic unit depletion/repletion experiments indicate that serum Mg concentrations decrease only after a prolonged depletion if an individual has good Mg reserves. These experiments also found that, although individuals had serum Mg concentrations approaching 0.85 mmol/L (2.06 mg/dL), they had physiological changes that respond to Mg supplementation. Thus, metabolic unit findings suggest that individuals with serum Mg concentrations >0.75 mmol/L (1.82 mg/L), or as high as 0.85 mmol/L (2.06 mg/dL), could have a deficit in Mg such that they respond to Mg supplementation, especially if they have a dietary intake history showing <250 mg (10.28 mmol)/day and a urinary excretion of <80 mg (3.29 mmol)/day.

Supplemental parenteral nutrition versus usual care in critically ill adults: a pilot randomized controlled study.

PubMed

Ridley, Emma J; Davies, Andrew R; Parke, Rachael; Bailey, Michael; McArthur, Colin; Gillanders, Lyn; Cooper, D James; McGuinness, Shay

2018-01-23

In the critically ill, energy delivery from enteral nutrition (EN) is often less than the estimated energy requirement. Parenteral nutrition (PN) as a supplement to EN may increase energy delivery. We aimed to determine if an individually titrated supplemental PN strategy commenced 48-72 hours following ICU admission and continued for up to 7 days would increase energy delivery to critically ill adults compared to usual care EN delivery. This study was a prospective, parallel group, phase II pilot trial conducted in six intensive care units in Australia and New Zealand. Mechanically ventilated adults with at least one organ failure and EN delivery below 80% of estimated energy requirement in the previous 24 hours received either a supplemental PN strategy (intervention group) or usual care EN delivery. EN in the usual care group could be supplemented with PN if EN remained insufficient after usual methods to optimise delivery were attempted. There were 100 patients included in the study and 99 analysed. Overall, 71% of the study population were male, with a mean (SD) age of 59 (17) years, Acute Physiology and Chronic Health Evaluation II score of 18.2 (6.7) and body mass index of 29.6 (5.8) kg/m 2 . Significantly greater energy (mean (SD) 1712 (511) calories vs. 1130 (601) calories, p < 0.0001) and proportion of estimated energy requirement (mean (SD) 83 (25) % vs. 53 (29) %, p < 0.0001) from EN and/or PN was delivered to the intervention group compared to usual care. Delivery of protein and proportion of estimated protein requirements were also greater in the intervention group (mean (SD) 86 (25) g, 86 (23) %) compared to usual care (mean (SD) 53 (29) g, 51 (25) %, p < 0.0001). Antibiotic use, ICU and hospital length of stay, mortality and functional outcomes were similar between the two groups. This individually titrated supplemental PN strategy applied over 7 days significantly increased energy delivery when compared to usual care delivery. Clinical and functional outcomes were similar between the two patient groups. Clinical Trial registry details: NCT01847534 (First registered 22 April 2013, last updated 31 July 2016).

40 CFR 86.402-78 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... atmosphere from any opening downstream from the exhaust port of a motor vehicle engine. Fuel system means the combination of fuel tank, fuel pump, fuel lines, oil injection metering system, and carburetor or fuel injection components, and includes all fuel system vents. Loaded vehicle mass means curb mass plus 80 kg...

40 CFR 86.402-78 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... atmosphere from any opening downstream from the exhaust port of a motor vehicle engine. Fuel system means the combination of fuel tank, fuel pump, fuel lines, oil injection metering system, and carburetor or fuel injection components, and includes all fuel system vents. Loaded vehicle mass means curb mass plus 80 kg...

40 CFR 86.402-78 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... atmosphere from any opening downstream from the exhaust port of a motor vehicle engine. Fuel system means the combination of fuel tank, fuel pump, fuel lines, oil injection metering system, and carburetor or fuel injection components, and includes all fuel system vents. Loaded vehicle mass means curb mass plus 80 kg...

40 CFR 86.402-78 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... atmosphere from any opening downstream from the exhaust port of a motor vehicle engine. Fuel system means the combination of fuel tank, fuel pump, fuel lines, oil injection metering system, and carburetor or fuel injection components, and includes all fuel system vents. Loaded vehicle mass means curb mass plus 80 kg...

40 CFR 86.402-78 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... atmosphere from any opening downstream from the exhaust port of a motor vehicle engine. Fuel system means the combination of fuel tank, fuel pump, fuel lines, oil injection metering system, and carburetor or fuel injection components, and includes all fuel system vents. Loaded vehicle mass means curb mass plus 80 kg...

Recognizing subtle evidence for silicic magma derivation from petrochemically-similar arc crust: Isotopic and chemical evidence for the bimodal volcanic series of Gorely Volcanic Center, Kamchatka, Russia

NASA Astrophysics Data System (ADS)

Seligman, A. N.; Bindeman, I. N.; Ellis, B. S.; Ponomareva, V.; Leonov, V.

2012-12-01

The Kamchatka Peninsula is home to some of the most prolific subduction related volcanic activity in the world. Gorely caldera and its central volcano are located in the rear of its currently active Eastern Volcanic Front. Recent work determined the presence of explosive ignimbrite eruptions sourced from Gorely volcano during the Pleistocene. We studied 32 eruptive units, including tephrochronologically-dated Holocene tephra, stratigraphically-arranged ignimbrites, as well as pre- and post-caldera lavas. We analyzed oxygen isotope ratios of pyroxene and plagioclase grains by laser fluorination, and major and trace element compositions of whole rocks. In addition, we determined 87Sr/86Sr and 143Nd/144Nd ratios of caldera-forming ignimbrite eruptions. Chemical compositions show that Gorely eruptive units range from basalt to basaltic andesite in the "Pra-Gorely" stages prior to caldera formation and the modern Gorely stages forming its current edifice. In contrast, eruptive material from earlier ignimbrites exposed at Opasny Ravine consists primarily of dacite. Whole rock analyses for Gorely indicate that silicic rocks and ignimbrites volumetrically dominate all other products, forming separate bimodal peaks in our SiO2-frequency diagram. In addition, trace element concentrations and ratios define two trends, one for more silicic and another for more mafic material. δ18Omelt values range from a low of 4.85 up to 6.22‰, where the lowest value was found in the last caldera forming eruption, suggesting incorporation of hydrothermally-altered material from earlier eruptions. 87Sr/86Sr and 143Nd/144Nd ratios range from 0.70328 to 0.70351 and from 0.51303 to 0.51309 respectively, with higher and more diverse values being characteristic of earlier ignimbrite units; again suggesting incorporation of surrounding crustal material. In contrast to these results, MELTS modeling using a variety of likely primitive basalts from Gorely shows it is possible to obtain silicic chemical compositions near the evolved ignimbrite compositions, strictly through 70-80% fractional crystallization at 1-2 kbars and NNO oxygen fugacity. The combination of light δ18O values as well as elevated 87Sr/86Sr and low 143Nd/144Nd values, in addition to the volumetric excess of silicic rocks suggest assimilation of the older and petrochemically-similar country-rocks (Karymshina volcano and/or the underlying Akhomten Massif). This research can be utilized for studies of other volcanoes at "long-term centers", underscoring the importance of using both isotopes and modeling of fractional crystallization to determine silicic magma derivation through coupled shallow crustal assimilation of similar older material and fractional crystallization.

Stray electrical currents in laparoscopic instruments used in da Vinci® robot-assisted surgery: an in vitro study.

PubMed

Mendez-Probst, Carlos E; Vilos, George; Fuller, Andrew; Fernandez, Alfonso; Borg, Paul; Galloway, David; Pautler, Stephen E

2011-09-01

The da Vinci(®) surgical system requires the use of electrosurgical instruments. The re-use of such instruments creates the potential for stray electrical currents from capacitive coupling and/or insulation failure. We used objective measures to report the prevalence and magnitude of such stray currents. Thirty-seven robotic instruments were tested using an electrosurgical unit (ESU) at pure coagulation and cut waveforms at four different settings. Conductive gel-coated instruments were tested at 40W, 80W, and maximum ESU output (coagulation 120W, cut 300W). The magnitude of stray currents was measured by an electrosurgical analyzer. At coagulation waveform in open air, 86% of instruments leaked a mean of 0.4W. In the presence of gel-coated instruments, stray currents were detected in all instruments with means (and standard deviation) of 3.4W (± 2), 4.1W (± 2.3), and 4.1W (± 2.3) at 40W, 80W, and 120W, respectively. At cut waveform in open air, none of the instruments leaked current, while gel-coated instruments leaked a mean of 2.2W (± 1.3), 2.2W (± 1.9) and 3.2W (± 1.9) at 40W, 80W, and 300W, respectively. All tested instruments in our study demonstrated energy leakage. Stray currents were higher during coagulation (high voltage) waveforms, and the magnitude was not always proportionate to the ESU settings. Stray currents have the potential to cause electrical burns. We support the programmed end of life of da Vinci instruments on the basis of safety. Consideration should be given to alternate energy sources or the adoption of active electrode monitoring technology to all monopolar instruments.

Traditional text-only versus multimedia-enhanced radiology reporting: referring physicians' perceptions of value.

PubMed

Sadigh, Gelareh; Hertweck, Timothy; Kao, Cristine; Wood, Paul; Hughes, Danny; Henry, Travis S; Duszak, Richard

2015-05-01

The aim of this study was to evaluate referring physicians' perceptions of multimedia-enhanced radiology reporting (MERR) as an alternative to traditional text-only radiology reporting. MERR supplements text-only reports by embedding user-friendly interactive hyperlinks to key images and graphically plotting target lesion size longitudinally over time. Of 402 physicians responding to a web-based survey, 200 (50 each medical oncologists, radiation oncologists, neurosurgeons, and pulmonologists) practicing in the United States fulfilled criteria to complete an online survey with questions focusing on satisfaction with current text-only reports and the perceived value of image- and data-enriched reporting. The mean respondent age was 46 years, with a mean of 15 years in posttraining clinical practice (85% men; 47% from academic medical centers). Although 80% were satisfied with the format of their current text-only radiology reports, 80% believed that MERR would represent an improvement. The most commonly reported advantages of MERR were "improved understanding of radiology findings by correlating images to text reports" (86%) and "easier access to images while monitoring progression of a disease/condition" (79%). Of the 28% of physicians with concerns about MERR implementation, the most common were that it was "too time intensive" (53%) and "the clinic workflow does not allow itself to view reports in such a fashion" (42%). Physicians indicated a strong increased likelihood of preferentially referring patients to (80%) and recommending peers to (79%) facilities that offer MERR. Most specialist referring physicians believe that interactive image- and data-embedded MERR represents an improvement over current text-only radiology reporting. Compared with current report formatting, most would preferentially refer patients and peers to facilities offering more meaningful image- and graphically enriched reporting platforms. Copyright © 2015 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Reliability and Construct Validity of the NEI VFQ-25 in a Subset of Patients With Geographic Atrophy From the Phase 2 Mahalo Study.

PubMed

Sivaprasad, Sobha; Tschosik, Elizabeth; Kapre, Audrey; Varma, Rohit; Bressler, Neil M; Kimel, Miriam; Dolan, Chantal; Silverman, David

2018-06-01

Geographic atrophy (GA) is an advanced form of age-related macular degeneration characterized by progressive, irreversible visual function loss. This analysis evaluates the psychometric properties of the 25-Item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) composite, near activity, and distance activity scores in patients with GA. Reliability and validity study. Reliability and validity were tested with NEI VFQ-25 data collected from 100 subjects with GA from United States' sites of the phase 2 Mahalo study of lampalizumab (ClinicalTrials.gov identifier: NCT01229215). Strong internal consistency and reproducibility were demonstrated for the NEI VFQ-25 composite (Cronbach's α, 0.95; intraclass correlation coefficient [ICC], 0.86), near activity (Cronbach's α, 0.84; ICC, 0.80), and distance activity (Cronbach's α, 0.84; ICC, 0.84) scores. Convergent validity with the binocular measures, Minnesota Low-Vision Reading Test (MNRead) reading speed and Functional Reading Independence (FRI) index score, was demonstrated for baseline NEI VFQ-25 composite (Pearson correlation [r] = 0.61 and 0.69, respectively), near activities (r = 0.69 and 0.73), and distance activities (r = 0.57 and 0.64) scores. Known-group validity testing for baseline mean NEI VFQ-25 scores (composite, near activities, and distance activities) showed differences between patients with mean maximum MNRead reading speed ≥ 80 vs < 80 words per minute, and between mean FRI index score ≥ 2.5 vs < 2.5 (all P < .0001). Psychometric evidence supports the NEI VFQ-25 as a reliable and valid cross-sectional measure of the impact of GA on patient visual function and vision-related quality of life. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Healthcare professionals' hand hygiene knowledge and beliefs in the United Arab Emirates.

PubMed

Ng, Wai Khuan; Shaban, Ramon Z; van de Mortel, Thea

2017-05-01

Hand hygiene at key moments during patient care is considered an important infection prevention and control measure to reduce healthcare-associated infections. While there is extensive research in Western settings, there is little in the United Arab Emirates where particular cultural and religious customs are thought to influence hand hygiene behaviour. To examine the hand hygiene knowledge and beliefs of health professionals at a tertiary care hospital in the United Arab Emirates. A mixed methods design employed a survey followed by focus groups with nurses and doctors. A total of 109 participants (13.6%) completed the survey: 96 nurses (88%) and 13 doctors (12%). Doctors' hand hygiene knowledge was slightly higher than that of nurses (78.5% versus 73.5%). There was no significant difference in scores on the hand hygiene beliefs scale between nurses (M = 103.06; SD = 8.0) and doctors (M = 99.00; SD = 10.53; t (80) = 1.55; p = 0.13, two-tailed). Seven categories emerged following transcript analysis. Hand hygiene knowledge scores suggest further hand hygiene education is required, especially on alcohol-based hand rub use. Addressing doctors' beliefs is particularly important given the leadership roles that doctors play in healthcare settings.

MMU development at the Martin Marietta plant in Denver, Colorado

NASA Image and Video Library

1980-07-25

S80-36889 (24 July 1980) --- Astronaut Bruce McCandless II uses a simulator at Martin Marietta?s space center near Denver to develop flight techniques for a backpack propulsion unit that will be used on Space Shuttle flights. The manned maneuvering unit (MMU) training simulator allows astronauts to "fly missions" against a full scale mockup of a portion of the orbiter vehicle. Controls of the simulator are like those of the actual MMU. Manipulating them allows the astronaut to move in three straight-line directions and in pitch, yaw and roll. One possible application of the MMU is for an extravehicular activity chore to repair damaged tiles on the vehicle. McCandless is wearing an extravehicular mobility unit (EMU).

A Brief History of International Latin American Student Fraternities: A Movement That Lasted 86 Years (1889-1975)

ERIC Educational Resources Information Center

Fajardo, Oliver

2015-01-01

An international Latin American student fraternity movement preceded the current Latino Greeks that are seen on college campuses today. This document provides new information that has not been published. The movement lasted 86 years and primarily served wealthy international Latin American students who came to the United States to study and, once…

Annual Research Progress Report, FY 1991

DTIC Science & Technology

1991-09-30

59 86/114 0 Natural History of HTLV-III Infection and Disease in a United States Military Community (PR) ............... . ............ 60 86/120 0...Malignant Lymphomas ..................... 142 90/147 0 SWOG 8819 Central Lymphoma Repository Tissue Procurement Protocol ........................... 143 90...Adjuvant Chemo- therapy with or without Endocrine Therapy in High- Risk, Node Negative Breast Cancer Patients and a Natural History Followup Study in Low

Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial.

PubMed

Akilen, R; Tsiami, A; Devendra, D; Robinson, N

2010-10-01

To determine the blood glucose lowering effect of cinnamon on HbA1c, blood pressure and lipid profiles in people with type 2 diabetes. 58 type 2 diabetic patients (25 males and 33 females), aged 54.9 ± 9.8, treated only with hypoglycemic agents and with an HbA1c more than 7% were randomly assigned to receive either 2g of cinnamon or placebo daily for 12 weeks. After intervention, the mean HbA1c was significantly decreased (P<0.005) in the cinnamon group (8.22% to 7.86%) compared with placebo group (8.55% to 8.68%). Mean systolic and diastolic blood pressures (SBP and DBP) were also significantly reduced (P<0.001) after 12 weeks in the cinnamon group (SBP: 132.6 to 129.2 mmHg and DBP: 85.2 to 80.2 mmHg) compared with the placebo group (SBP: 134.5 to 134.9 mmHg and DBP: 86.8 to 86.1 mmHg). A significant reduction in fasting plasma glucose (FPG), waist circumference and body mass index (BMI) was observed at week 12 compared to baseline in the cinnamon group, however, the changes were not significant when compared to placebo group. There were no significant differences in serum lipid profiles of total cholesterol, triglycerides, HDL and LDL cholesterols neither between nor within the groups. Intake of 2g of cinnamon for 12 weeks significantly reduces the HbA1c, SBP and DBP among poorly controlled type 2 diabetes patients. Cinnamon supplementation could be considered as an additional dietary supplement option to regulate blood glucose and blood pressure levels along with conventional medications to treat type 2 diabetes mellitus. © 2010 The Authors. Diabetic Medicine © 2010 Diabetes UK.

40 CFR 81.86 - Metropolitan Sioux City Interstate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Metropolitan Sioux City Interstate Air... Air Quality Control Regions § 81.86 Metropolitan Sioux City Interstate Air Quality Control Region. The Metropolitan Sioux City Interstate Air Quality Control Region (Iowa-Nebraska-South Dakota) consists of the...

40 CFR 81.86 - Metropolitan Sioux City Interstate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Metropolitan Sioux City Interstate Air... Air Quality Control Regions § 81.86 Metropolitan Sioux City Interstate Air Quality Control Region. The Metropolitan Sioux City Interstate Air Quality Control Region (Iowa-Nebraska-South Dakota) consists of the...

Vaping to lose weight: Predictors of adult e-cigarette use for weight loss or control.

PubMed

Morean, Meghan E; Wedel, Amelia V

2017-03-01

Some traditional cigarette smokers are motivated to smoke to lose weight or control their weight. The current study evaluated whether a subset of adult e-cigarette users reported vaping to lose or control their weight and examined potential predictors of vaping for weight management. Adult e-cigarette users (n=459) who reported wanting to lose weight or maintain their weight completed an anonymous online survey. Participants reported on demographics, vaping frequency, e-cigarette nicotine content, cigarette smoking status, preferred e-cigarette/e-liquid flavors, current weight status (i.e., overweight, underweight), use of dieting strategies associated with anorexia and bulimia, lifetime history of binge eating, self-discipline, and impulse control. Binary logistic regression was used to examine whether vaping for weight loss/control was associated with the aforementioned variables. Participants who reported vaping for weight loss/control (13.5%) were more likely to vape frequently (adjOR=1.15; 95% CI [1.00, 1.31]); be overweight (adjOR=2.80; [1.33, 5.90]); restrict calories (adjOR=2.23; [1.13, 4.42]); have poor impulse control (adjOR=0.59; [0.41, 0.86]); and prefer coffee- (adjOR=2.92; [1.47, 5.80]) or vanilla-flavored e-liquid (adjOR=7.44; [1.56, 36.08]). A subset of adult e-cigarette users reported vaping for weight loss/control, raising concerns about expanded, scientifically unsubstantiated uses of e-cigarettes. Identifying where individuals obtain information about vaping for weight loss (e.g., e-cigarette ads, Internet) and whether weight-related motives promote e-cigarette initiation among e-cigarette naïve individuals is important to informing regulatory efforts. Further research also is needed to better understand the link between e-liquid flavors and weight loss motivations. Copyright © 2016 Elsevier Ltd. All rights reserved.

40 CFR 86.1438 - Test run-EPA.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Test run-EPA. 86.1438 Section 86.1438 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Short Test Procedures § 86.1438 Test run—EPA. (a) This section describes the test run performed by the...

40 CFR 86.1438 - Test run-EPA.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Test run-EPA. 86.1438 Section 86.1438 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Short Test Procedures § 86.1438 Test run—EPA. (a) This section describes the test run performed by the...

40 CFR 86.430-78 - Vehicle failure.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Vehicle failure. 86.430-78 Section 86...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1978 and Later New Motorcycles, General Provisions § 86.430-78 Vehicle failure. Any test vehicle which incurs...

40 CFR 86.430-78 - Vehicle failure.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Vehicle failure. 86.430-78 Section 86...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1978 and Later New Motorcycles, General Provisions § 86.430-78 Vehicle failure. Any test vehicle which incurs...

40 CFR 86.430-78 - Vehicle failure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Vehicle failure. 86.430-78 Section 86...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1978 and Later New Motorcycles, General Provisions § 86.430-78 Vehicle failure. Any test vehicle which incurs...

40 CFR 86.430-78 - Vehicle failure.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Vehicle failure. 86.430-78 Section 86...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1978 and Later New Motorcycles, General Provisions § 86.430-78 Vehicle failure. Any test vehicle which incurs...

40 CFR 86.423-78 - Test vehicles.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Test vehicles. 86.423-78 Section 86...) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1978 and Later New Motorcycles, General Provisions § 86.423-78 Test vehicles. (a)(1) Before beginning service...