Addressing controversies in science education: a pragmatic approach to evolution education

NASA Astrophysics Data System (ADS)

Hildebrand, David; Bilica, Kimberly; Capps, John

2008-09-01

Science education controversies typically prove more intractable than those in scientific research because they involve a wider range of considerations (e.g., epistemic, social, ethical, political, and religious). How can educators acknowledge central issues in a controversy (such as evolution)? How can such problems be addressed in a way that is ethically sensitive and intellectually responsible? Drawing in part on pragmatic philosopher John Dewey, our solution is politically proactive, philosophically pragmatic, and grounded in research. Central to our proposal is (1) steps toward creating a philosophical “total attitude” that is democratic, imaginative, and hypothetical; (2) a deeper understanding of how scientific theories can be pragmatically true; and (3) an assessment of differing pedagogical approaches for teaching evolution in the classroom.

Non compaction cardiomyopathy: Review of a controversial entity.

PubMed

Lorca, Rebeca; Rozado, José; Martín, María

2018-05-11

Non-compaction cardiomyopathy is a heterogeneous and complex entity concerning which there are still many doubts to be resolved. While the American Heart Association includes it among genetic cardiomyopathies, the European Society of Cardiology treats it as an unclassified cardiomyopathy. It may present in a sporadic or familial form, isolated or associated with other heart diseases, affecting only the left ventricle or both and can sometimes appear as a mixed phenotype in patients with other cardiomyopathies. Different forms of clinical presentation are also associated with its different morphological manifestations, and even non-compaction of the left ventricle may be triggered by other physiological or pathological processes. The purpose of this review is an update of this entity and its controversies. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

Plutonium controversy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richmond, C.R.

1980-01-01

The toxicity of plutonium is discussed, particularly in relation to controversies surrounding the setting of radiation protection standards. The sources, amounts of, and exposure pathways of plutonium are given and the public risk estimated. (ACR)

The Cretaceous/Tertiary Extinction Controversy.

ERIC Educational Resources Information Center

McCartney, Kevin

1984-01-01

The cause of the Cretaceous/Tertiary extinction has become a major geologic controversy. Current evidence for the two opposing views is reviewed to provide an introduction to the controversy and to form the basis for a seminar of discussion topic. (Author/JN)

Controversies in colorectal cancer screening.

PubMed

Pox, Christian P

2014-01-01

Colorectal cancer (CRC) is one of the most common cancers worldwide and a good candidate for screening programmes. However, there is controversy concerning which of the available screening tests should be used. There is general agreement that screening for CRC in the asymptomatic population should begin at the age of 50. Several different screening methods are available which can be separated into those that mainly detect cancers: faecal occult blood tests [guaiac (FOBT) and immunochemical (FIT)], genetic stool tests, blood tests and the M2-pyruvate kinase (M2-PK) test. Methods that detect cancers and polyps are colonoscopy, sigmoidoscopy, CT-colonography (CT-C) and colon capsule endoscopy. The only tests for which a reduction in CRC mortality compared to no screening have been proven in randomized trials are FOBT and sigmoidoscopy. Several trials suggest that FIT are superior to FOBT in terms of detection rates of cancers and advanced adenomas and possibly compliance. There is indirect evidence suggesting efficacy of colonoscopy as a screening test. The role of CT-C is controversial. There is data suggesting a good sensitivity for neoplasia >9 mm with a lower sensitivity for smaller neoplasia. However, radiation exposure is considered a major limitation in some countries. Unresolved questions include the lesion cut-off for referral to colonoscopy and work-up of extracolonic findings. For other methods, like genetic stool testing using newer markers, blood tests, capsule endoscopy and M2-PK, there is currently insufficient data on screening of the asymptomatic population. Key Messages: Colorectal screening is recommended and should be performed in the form of an organized programme. If detection of early-stage cancers is the aim of a screening programme, FIT seem to be superior to FOBT. If detection and removal of adenomas is the aim of a screening programme, endoscopic methods seem to be good alternatives. Sigmoidoscopy is easier to perform but will likely only

Teen Addiction. Current Controversies Series.

ERIC Educational Resources Information Center

Winters, Paul A., Ed.

The Current Controversies series explores social, political, and economic controversies that dominate the national and international scenes today from a variety of perspectives. Recent surveys have shown that, after years of decline, drug use among teenagers has increased during the 1990s, and that alcohol and tobacco use have remained…

Sensitive skin in Europe.

PubMed

Misery, L; Boussetta, S; Nocera, T; Perez-Cullell, N; Taieb, C

2009-04-01

Sensitive skin appears as a very frequent condition, but there is no comparative data between countries. To perform an epidemiological approach to skin sensitivity in different European countries. An opinion poll was conducted in eight European countries: Belgium, France, Germany, Greece, Italy, Portugal, Spain and Switzerland. This sample (4506 persons) was drawn from a representative sample of each population aged 15 years or older. Sensitive or very sensitive skin was declared by 38.4% and slightly or not sensitive skin by 61.6%. Women declared more sensitive skin than men. A dermatological disease was declared by 31.2% of people with very sensitive skin, 17.6% of those with sensitive skin, 8.7% of those with slightly sensitive skin and 3.7% of those who do not have sensitive skin. A history of childhood atopic dermatitis was more frequent in patients with sensitive or very sensitive skin. The interviewees who declared that they had dry or oily skin also reported significantly more frequently sensitive or very sensitive skin than those with normal skin. Sensitive and very sensitive skins were clearly more frequent in Italy and France. This study is the first study that compares skin sensitivity in European countries. Prevalence is high, but significant differences are noted between these countries. Dermatological antecedents (or treatments?) could be involved in the occurrence of skin sensitivity.

Anatomy of a Book Controversy.

ERIC Educational Resources Information Center

Homstad, Wayne

A major controversy arose in 1987 in a midwestern school district, after a middle school teacher assigned the novel "Go Ask Alice" to her seventh-grade class. This book describes the district's attempt to answer two basic questions: What should students read? and Who should decide what students read? The book controversy is first…

Responsibility-sensitive fairness in health financing: judgments in four European countries.

PubMed

Le Clainche, Christine; Wittwer, Jerome

2015-04-01

Risky health behaviours substantially increase medical and social costs. We document the extent to which a sample of European students (from Denmark, France, Italy and Sweden) consider that individuals should assume the financial burden of paying the costs of risky behaviour. We test the acceptability of different ways of financing costs because of ill health that is more or less associated with risky behaviour in accordance with a normative framework relating to responsibility-sensitive fairness. We find that the majority of students agree with assuming financial responsibility for risky behaviours and that there should be compensation for unfavourable circumstances. Students agree that two individuals with the same responsibility variables should make an equal financial contribution and that more effort in maintaining health for given circumstances should be rewarded with a lower financial contribution. The specific health context and the type of risky behaviours involved matter in determining perceptions of justice in health financing. Copyright © 2014 John Wiley & Sons, Ltd.

Contrasting Controversies: Fracking and Climate Change

NASA Astrophysics Data System (ADS)

Duggan-Haas, D.; Zabel, I. H. H.; Ross, R. M.

2014-12-01

Slickwater high-volume hydraulic fracturing (commonly known as "fracking") is highly controversial. So is global warming, and the two issues are closely related, but the natures of these two controversies have substantial and important differences. Building upon years of experience in teaching and developing resources and strategies for teaching about evolution and climate change, staff at the Paleontological Research Institution have engaged in public outreach and educator professional development to help nurture understanding of fracking and the broader energy system. How are these controversies similar to and different from one another, and how should understanding these similarities and differences inform educational programming (and about how you talk about these issues with your Uncle Fred at the family holiday dinner?). It is nearly universally agreed amongst scientists who study climate that changes now underway are real and human caused, and are posing or likely to pose very serious problems for humanity. Scientists who study slickwater high-volume hydraulic fracturing agree that it causes environmental damage, but there is no consensus as to whether fracking causes more or less harm (e.g., among different kinds of environment harm, across different temporal and spatial scales, and among different social contexts) than other ways of producing energy on a large scale. In other words, the basic tenets of climate change are not a matter of scientific controversy, though the implications for policy making obviously remain politically controversial, while fracking is an issue of both scientific and political controversy. Without advocating for or against fracking, we help audiences disentangle scientific and political issues, better understand the energy resources used in their own communities, and consider issues of scale, systems, and complexity. We will compare and contrast the overlapping controversies surrounding climate change and fracking and highlight

History Forum Addresses Creation/Evolution Controversy.

ERIC Educational Resources Information Center

Schweinsberg, John

1997-01-01

A series of programs entitled Creationism and Evolution: The History of a Controversy was presented at the University of Alabama in Huntsville. The controversy was addressed from an historical and sociological, rather than a scientific perspective. Speakers addressed the evolution of scientific creationism, ancient texts versus sedimentary rocks…

Diagnosis and management of clinical and subclinical cobalamin deficiencies: why controversies persist in the age of sensitive metabolic testing.

PubMed

Carmel, Ralph

2013-05-01

In the past two decades, sensitive biochemical tests have uncovered cobalamin deficiency much more frequently than ever before. Almost all cases involve mild, biochemical changes without clinical manifestations (subclinical cobalamin deficiency; SCCD), whose health impact is unclear. Because the causes of SCCD are most often unknown, nonmalabsorptive, and seldom documented, controversy and confusion surround the diagnostic criteria and, inevitably, consequences and management of SCCD. To complicate matters, our grasp of the rarer clinical deficiency, usually a serious, progressive medical disease rooted in severe malabsorption, has receded as absorption testing has disappeared. Reexamining the accumulation of assumptions and misperceptions about cobalamin deficiency and distinguishing SCCD from clinical deficiency is long overdue. The biology of cobalamin provides an important starting point: cobalamin stores exceed daily losses so greatly and binding proteins regulate absorption so effectively that deficiency typically achieves clinical expression only after years of severe, relentless malabsorption. Dietary insufficiency, mild, partial malabsorption, and other incomplete, intermittent causes can usually produce only SCCD. Thus, the most fundamental difference between the two deficiencies is the relentlessness of the underlying cause, which determines prognosis and health impact. Inattention to absorptive status has exacerbated the limitations of biochemical testing. All the biochemical tests are highly sensitive but specificity is poor, no diagnostic gold standard exists, and diagnostic cutpoints fluctuate excessively. To limit the adverse diagnostic consequences, the diagnosis of SCCD, whose need for treatment is unclear, should be deferred unless at least two tests are abnormal. Indeed, cobalamin biology indicates that the absorption system, while enhancing cobalamin delivery, also sets a strict upper limit on it, which suggests that cobalamin excess is

The Reviewing of Controversial Juvenile Books: A Study.

ERIC Educational Resources Information Center

Crow, Sherry R.

1986-01-01

Describes a study which examined reviewers' treatment of controversial juvenile books in Booklist, Bulletin of Center for Children's Books, Horn Book, and School Library Journal. The total number of controversial books reviewed by each journal, promptness of reviews, and extent of discussion of controversial features are discussed. (MBR)

Media Coverage and Public Opinion on Scientific Controversies.

ERIC Educational Resources Information Center

Mazur, Allan

1981-01-01

Examines the relationship of media coverage and public opinion in scientific controversy. A survey of coverage of controversies arising regarding sociobiology, water fluoridation, nuclear power and the Three Mile Island disaster indicates that the media play an active role in shaping and constructing controversy rather than just reporting it. (JMF)

Participation rate or informed choice? Rethinking the European key performance indicators for mammography screening.

PubMed

Strech, Daniel

2014-03-01

Despite the intensive controversies about the likelihood of benefits and harms of mammography screening almost all experts conclude that the choice to screen or not to screen needs to be made by the individual patient who is adequately informed. However, the "European guideline for quality assurance in breast cancer screening and diagnosis" specifies a participation rate of 70% as the key performance indicator for mammography screening. This paper argues that neither the existing evidence on benefits and harms, nor survey research with women, nor compliance rates in clinical trials, nor cost-effectiveness ratios justify participation rates as a reasonable performance indicator for preference-sensitive condition such as mammography screening. In contrast, an informed choice rate would be more reasonable. Further research needs to address the practical challenges in assessing informed choice rates. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Asian and European American cultural values and communication styles among Asian American and European American college students.

PubMed

Park, Yong S; Kim, Bryan S K

2008-01-01

The present study examined the relationships between adherence to Asian and European cultural values and communication styles among 210 Asian American and 136 European American college students. A principal components analysis revealed that, for both Asian Americans and European Americans, the contentious, dramatic, precise, and open styles loaded onto the first component suggesting low context communication, and interpersonal sensitivity and inferring meaning styles loaded onto the second component suggesting high context communication. Higher adherence to emotional self-control and lower adherence to European American values explained Asian Americans' higher use of the indirect communication, while higher emotional self-control explained why Asian Americans use a less open communication style than their European American counterparts. When differences between sex and race were controlled, adherence to humility was inversely related to contentious and dramatic communication styles but directly related to inferring meaning style, adherence to European American values was positively associated with precise communication and inferring meaning styles, and collectivism was positively related to interpersonal sensitivity style. 2008 APA

Teachers, Classroom Controversy, and the Media

ERIC Educational Resources Information Center

Faulconer, Tracy; Freeman, Ayesha Coning

2005-01-01

This article discusses the relationship between teachers, classroom controversy and the media. It also features the story of Ayesha, who coincidentally is one of the authors of this article. Ayesha's story is a social studies teacher's bad dream featuring one of her worst fears: (1) public criticism; and (2) controversy over something that has…

Streamlining antibiotic therapy with procalcitonin protocols: consensus and controversies.

PubMed

Haubitz, Sebastian; Mueller, Beat; Schuetz, Philipp

2013-04-01

Accumulating evidence supports procalcitonin (PCT) as an accurate surrogate biomarker for likelihood and severity of bacterial infections. In community-acquired pneumonia and other respiratory infections, PCT-guided antibiotic therapy algorithms resulted in reduced antibiotic exposure while maintaining a similar or even better level of safety compared with standard care. Reductions in antibiotic use translate into lower treatment costs, decreased risk of side effects and decreased bacterial multiresistance. This is especially important, as acute respiratory infections represent the most frequent reason for antibiotic prescriptions worldwide. Still, there is some controversy about the benefits of PCT measurement in sepsis patients in the intensive care unit and for nonrespiratory infections. Highly sensitive PCT assays are readily available in many hospitals today, and point-of-care assays with high enough sensitivity for antibiotic guidance are expected to be available soon. Herein, the authors provide an overview of recent studies evaluating PCT in different clinical situations and an outlook of currently enrolling or upcoming interventional trials.

Converging Climate Sensitivities of European Forests Between Observed Radial Tree Growth and Vegetation Models

NASA Technical Reports Server (NTRS)

Zhang, Zhen; Babst, Flurin; Bellassen, Valentin; Frank, David; Launois, Thomas; Tan, Kun; Ciais, Philippe; Poulter, Benjamin

2017-01-01

The impacts of climate variability and trends on European forests are unevenly distributed across different bioclimatic zones and species. Extreme climate events are also becoming more frequent and it is unknown how they will affect feed backs of CO2 between forest ecosystems and the atmosphere. An improved understanding of species differences at the regional scale of the response of forest productivity to climate variation and extremes is thus important for forecasting forest dynamics. In this study, we evaluate the climate sensitivity of above ground net primary production (NPP) simulated by two dynamic global vegetation models (DGVM; ORCHIDEE and LPJ-wsl) against tree ring width (TRW) observations from about1000 sites distributed across Europe. In both the model simulations and the TRW observations, forests in northern Europe and the Alps respond positively to warmer spring and summer temperature, and their overall temperature sensitivity is larger than that of the soil-moisture-limited forests in central Europe and Mediterranean regions. Compared with TRW observations, simulated NPP from ORCHIDEE and LPJ-wsl appear to be overly sensitive to climatic factors. Our results indicate that the models lack biological processes that control time lags, such as carbohydrate storage and remobilization, that delay the effects of radial growth dynamics to climate. Our study highlights the need for re-evaluating the physiological controls on the climate sensitivity of NPP simulated by DGVMs. In particular, DGVMs could be further enhanced by a more detailed representation of carbon reserves and allocation that control year-to year variation in plant growth.

Sexual Orientation, Controversy, and Science.

PubMed

Bailey, J Michael; Vasey, Paul L; Diamond, Lisa M; Breedlove, S Marc; Vilain, Eric; Epprecht, Marc

2016-09-01

SummaryOngoing political controversies around the world exemplify a long-standing and widespread preoccupation with the acceptability of homosexuality. Nonheterosexual people have seen dramatic surges both in their rights and in positive public opinion in many Western countries. In contrast, in much of Africa, the Middle East, the Caribbean, Oceania, and parts of Asia, homosexual behavior remains illegal and severely punishable, with some countries retaining the death penalty for it. Political controversies about sexual orientation have often overlapped with scientific controversies. That is, participants on both sides of the sociopolitical debates have tended to believe that scientific findings-and scientific truths-about sexual orientation matter a great deal in making political decisions. The most contentious scientific issues have concerned the causes of sexual orientation-that is, why are some people heterosexual, others bisexual, and others homosexual? The actual relevance of these issues to social, political, and ethical decisions is often poorly justified, however. © The Author(s) 2016.

The Choice Controversy.

ERIC Educational Resources Information Center

Cookson, Peter W., Jr., Ed.

Issues in school choice--constitutionality, feasibility, equity, and educational productivity--are examined in this book. The controversy requires an ongoing analysis of the origins of the school-choice movement, the kinds of plans proposed and implemented, their educational and social consequences, and the philosophical assumptions underlying the…

Controversies in dengue pathogenesis

PubMed Central

Halstead, Scott B

2012-01-01

Research into the pathogenesis of dengue fever has exploded over the last half-century, with issues that were considered simple becoming more complex as additional data are found. This has led to the development of a number of controversies that are being studied across the globe and debated in the literature. In this paper, the following six controversies are analysed and, where possible, resolved: the 1997 World Health Organization (WHO) case definition of dengue haemorrhagic fever (DHF) is not useful; DHF is not significantly associated with secondary dengue infection; DHF results from infection with a ‘virulent’ dengue virus; DHF is owing to abnormal T-cell responses; DHF results from auto-immune responses; and DHF results from direct infection of endothelial cells. PMID:22668442

Evolutionary Psychology: Controversies, Questions, Prospects, and Limitations

ERIC Educational Resources Information Center

Confer, Jaime C.; Easton, Judith A.; Fleischman, Diana S.; Goetz, Cari D.; Lewis, David M. G.; Perilloux, Carin; Buss, David M.

2010-01-01

Evolutionary psychology has emerged over the past 15 years as a major theoretical perspective, generating an increasing volume of empirical studies and assuming a larger presence within psychological science. At the same time, it has generated critiques and remains controversial among some psychologists. Some of the controversy stems from…

Penetrating abdominal injuries: management controversies

PubMed Central

Butt, Muhammad U; Zacharias, Nikolaos; Velmahos, George C

2009-01-01

Penetrating abdominal injuries have been traditionally managed by routine laparotomy. New understanding of trajectories, potential for organ injury, and correlation with advanced radiographic imaging has allowed a shift towards non-operative management of appropriate cases. Although a selective approach has been established for stab wounds, the management of abdominal gunshot wounds remains a matter of controversy. In this chapter we describe the rationale and methodology of selecting patients for non-operative management. We also discuss additional controversial issues, as related to antibiotic prophylaxis, management of asymptomatic thoracoabdominal injuries, and the use of colostomy vs. primary repair for colon injuries. PMID:19374761

Controversies in Persistent (Chronic) Lyme Disease

PubMed Central

2016-01-01

The Centers for Disease Control and Prevention estimates that more than 300 000 new cases of Lyme disease occur each year in the United States and that 10% to 20% of these patients will remain symptomatic despite receiving appropriate antibiotic therapy. Many elements of the disease are poorly understood and have generated considerable controversy. This paper discusses the medical controversies related to posttreatment manifestations and their potential impact on infusion nurses. PMID:27755213

History Textbook Controversies in Japan. ERIC Digest.

ERIC Educational Resources Information Center

Masalski, Kathleen Woods

Currently, there is a controversy in Japan about textbook treatments of Japanese military actions during World War II. This digest examines: (1) the importance of history textbooks in schools in Japan and the United States; (2) the context of history textbook controversies in Japan; (3) the current issues and contending positions in the Japanese…

Adolescent Controversial Status Brokers: A Double-Edged Sword

PubMed Central

Borowski, Sarah; Zeman, Janice; Carboni, Inga; Gilman, Rich; Thrash, Todd

2016-01-01

Using a 3-wave longitudinal, multidimensional approach, this study investigated the influence of social network position and social status on psychosocial outcomes of 440 youth (45.1% girls; Mage = 16.1; 90.9% Caucasian) over 26 months, focusing on the controversial status classification (i.e., youth who are both highly liked and disliked by their peers). Brokerage (i.e., the degree to which a person has relationships with peers who do not have a direct relationship with each other) was examined in conjunction with sociometric status to explain potential heterogeneity of outcomes for controversial status youth. Adolescents completed peer nominations and self-reports of adjustment. Results demonstrated that brokerage related to poorer psychosocial outcomes for controversial than average status youth. Brokerage appears to add predictive value to youths’ adjustment beyond traditional sociometric classifications, especially for controversial status youth. PMID:27428447

Can lagrangian models reproduce the migration time of European eel obtained from otolith analysis?

NASA Astrophysics Data System (ADS)

Rodríguez-Díaz, L.; Gómez-Gesteira, M.

2017-12-01

European eel can be found at the Bay of Biscay after a long migration across the Atlantic. The duration of migration, which takes place at larval stage, is of primary importance to understand eel ecology and, hence, its survival. This duration is still a controversial matter since it can range from 7 months to > 4 years depending on the method to estimate duration. The minimum migration duration estimated from our lagrangian model is similar to the duration obtained from the microstructure of eel otoliths, which is typically on the order of 7-9 months. The lagrangian model showed to be sensitive to different conditions like spatial and time resolution, release depth, release area and initial distribution. In general, migration showed to be faster when decreasing the depth and increasing the resolution of the model. In average, the fastest migration was obtained when only advective horizontal movement was considered. However, faster migration was even obtained in some cases when locally oriented random migration was taken into account.

Covering Conflict and Controversy: Measuring Balance, Fairness, Defamation.

ERIC Educational Resources Information Center

Simon, Todd F.; And Others

1989-01-01

Measures balance, fairness, and defamation in local stories containing controversy and covering law enforcement, education, local government, and business. Finds that most stories lack balance and that the opposing side of the controversy was not contacted in 28 percent of the instances. (RS)

Epstein–Barr virus in the multiple sclerosis brain: a controversial issue—report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria

PubMed Central

Niedobitek, Gerald; Aloisi, Francesca; Middeldorp, Jaap M.

2011-01-01

Recent epidemiological and immunological studies provide evidence for an association between Epstein–Barr virus infection and multiple sclerosis, suggesting a role of Epstein–Barr virus infection in disease induction and pathogenesis. A key question in this context is whether Epstein–Barr virus-infected B lymphocytes are present within the central nervous system and the lesions of patients with multiple sclerosis. Previous studies on this topic provided highly controversial results, showing Epstein–Barr virus reactivity in B cells in the vast majority of multiple sclerosis cases and lesions, or only exceptional Epstein–Barr virus-positive B cells in rare cases. In an attempt to explain the reasons for these divergent results, a workshop was organized under the umbrella of the European Union FP6 NeuroproMiSe project, the outcome of which is presented here. This report summarizes the current knowledge of Epstein–Barr virus biology and shows that Epstein–Barr virus infection is highly complex. There are still major controversies, how to unequivocally identify Epstein–Barr virus infection in pathological tissues, particularly in situations other than Epstein–Barr virus-driven lymphomas or acute Epstein–Barr virus infections. It further highlights that unequivocal proof of Epstein–Barr virus infection in multiple sclerosis lesions is still lacking, due to issues related to the sensitivity and specificity of the detection methods. PMID:21846731

The Procedurally Directive Approach to Teaching Controversial Issues

ERIC Educational Resources Information Center

Gregory, Maughn Rollins

2014-01-01

Recent articles on teaching controversial topics in schools have employed Michael Hand's distinction between "directive teaching," in which teachers attempt to persuade students of correct positions on topics that are not rationally controversial, and "nondirective teaching," in which teachers avoid persuading students on…

Evidence to support controversy in microsurgery.

PubMed

Fan, Kenneth L; Patel, Ketan M; Mardini, Samir; Attinger, Christopher; Levin, L Scott; Evans, Karen K

2015-03-01

Microsurgery practice, including preoperative patient selection, intraoperative technique, and anesthetic considerations, varies from institution to institution and from surgeon to surgeon. Many surgeons' practices are driven by "conventional wisdom," which is handed down from mentors to fellows and residents. In this article, the authors explore the oxymoron that there is evidence to support controversy in microsurgery. Indeed, if there was convincing evidence to support varying microsurgery practices, there would be no controversy. The authors conducted a review with a focus on evidence-based medicine to support microsurgery practice.

37 CFR 251.72 - Declaration of controversy: Initiation of arbitration proceeding.

Code of Federal Regulations, 2010 CFR

2010-07-01

... controversy: Initiation of arbitration proceeding. If the Librarian determines that a controversy exists among... royalties, the Librarian shall publish in the Federal Register a declaration of controversy along with a...

Ground-Based Optical Measurements at European Flux Sites: A Review of Methods, Instruments and Current Controversies

PubMed Central

Balzarolo, Manuela; Anderson, Karen; Nichol, Caroline; Rossini, Micol; Vescovo, Loris; Arriga, Nicola; Wohlfahrt, Georg; Calvet, Jean-Christophe; Carrara, Arnaud; Cerasoli, Sofia; Cogliati, Sergio; Daumard, Fabrice; Eklundh, Lars; Elbers, Jan A.; Evrendilek, Fatih; Handcock, Rebecca N.; Kaduk, Joerg; Klumpp, Katja; Longdoz, Bernard; Matteucci, Giorgio; Meroni, Michele; Montagnani, Lenoardo; Ourcival, Jean-Marc; Sánchez-Cañete, Enrique P.; Pontailler, Jean-Yves; Juszczak, Radoslaw; Scholes, Bob; Martín, M. Pilar

2011-01-01

This paper reviews the currently available optical sensors, their limitations and opportunities for deployment at Eddy Covariance (EC) sites in Europe. This review is based on the results obtained from an online survey designed and disseminated by the Co-cooperation in Science and Technology (COST) Action ESO903—“Spectral Sampling Tools for Vegetation Biophysical Parameters and Flux Measurements in Europe” that provided a complete view on spectral sampling activities carried out within the different research teams in European countries. The results have highlighted that a wide variety of optical sensors are in use at flux sites across Europe, and responses further demonstrated that users were not always fully aware of the key issues underpinning repeatability and the reproducibility of their spectral measurements. The key findings of this survey point towards the need for greater awareness of the need for standardisation and development of a common protocol of optical sampling at the European EC sites. PMID:22164055

Domesticating Biotechnology: How London's Science Museum Has Framed the Controversy.

ERIC Educational Resources Information Center

Levidow, Les

1998-01-01

Exhibits in London's Science Museum are critiqued in this discussion of the problem of balance in presenting controversial issues in museum exhibits. Science museums claim to portray controversial issues in a neutral manner, but neutrality is impossible. Asks how science museums can involve visitors in the controversy and how the museum's role can…

Controversial Higher-Education Reforms Spark Riots in Athens

ERIC Educational Resources Information Center

Labi, Aisha

2007-01-01

This article discusses the Greek Parliament's controversial education bill passed recently that sparked riots and unrest in Athens. The government's controversial education package includes measures that would limit the number of years students can take to complete a university degree and would curtail university asylum laws. A separate proposal…

Controversies in faith and health care.

PubMed

Tomkins, Andrew; Duff, Jean; Fitzgibbon, Atallah; Karam, Azza; Mills, Edward J; Munnings, Keith; Smith, Sally; Seshadri, Shreelata Rao; Steinberg, Avraham; Vitillo, Robert; Yugi, Philemon

2015-10-31

Differences in religious faith-based viewpoints (controversies) on the sanctity of human life, acceptable behaviour, health-care technologies and health-care services contribute to the widespread variations in health care worldwide. Faith-linked controversies include family planning, child protection (especially child marriage, female genital mutilation, and immunisation), stigma and harm reduction, violence against women, sexual and reproductive health and HIV, gender, end-of-life issues, and faith activities including prayer. Buddhism, Christianity, Hinduism, Islam, Judaism, and traditional beliefs have similarities and differences in their viewpoints. Improved understanding by health-care providers of the heterogeneity of viewpoints, both within and between faiths, and their effect on health care is important for clinical medicine, public-health programmes, and health-care policy. Increased appreciation in faith leaders of the effect of their teachings on health care is also crucial. This Series paper outlines some faith-related controversies, describes how they influence health-care provision and uptake, and identifies opportunities for research and increased interaction between faith leaders and health-care providers to improve health care. Copyright © 2015 Elsevier Ltd. All rights reserved.

A Rhetoric of Controversy.

ERIC Educational Resources Information Center

Phillips, Kendall R.

1999-01-01

Contributes to scholarship advancing the understanding of human communication by exploring the concept of controversy within a theoretical framework which does not presume the existence of a public sphere. Suggests an alternative perspective based on the intersection of moments of opportunity and specific sites of discourse. Applies this…

What's Wrong with the "Teach the Controversy" Slogan?

ERIC Educational Resources Information Center

Scott, Eugenie C.

2007-01-01

Teachers are often exhorted by creationists to "teach the controversy." Although such encouragement sounds on the surface like a proposal for critical thinking instruction, the history of the creationist movement in North America belies this claim. Rather than teach students to analyze and evaluate actual scientific controversies, the intent of…

Literature for Children: Avoiding Controversy and Intellectual Challenge.

ERIC Educational Resources Information Center

Adams, Dennis M.

1986-01-01

Discusses lack of literature on controversial subjects that can help prepare children and young adults to deal perceptively with complexities of modern world. Highlights include meeting the issues head-on, glorifying armed conflict in video media, avoiding issues of nuclear war, and intellectual depth and dealing with controversial issues. (12…

Censorship: Managing the Controversy.

ERIC Educational Resources Information Center

National School Boards Association, Alexandria, VA.

In this monograph, certain viewpoints, strategies, and policy tips have been separated from the main text. These "notebooks" of information, taken together, comprise a useful handbook for school officials who want to recognize censorship, put it in perspective, and prepare for consequent controversy. The purpose is to provide workable strategies…

Schizophrenia in children: a review of European research.

PubMed

Tsiantis, J; Macri, I; Maratos, O

1986-01-01

European literature on childhood schizophrenia is divergent and vast. The topic itself is controversial and complex. The article reviews selected European literature on childhood schizophrenia and presents the most important trends of research from the literature. Extensive work has been devoted in tracing and defining the boundaries of childhood schizophrenia from infantile psychosis, autism, organic psychoses, and borderline states, and of mapping out the condition. The factor of development as an important variable when studying diagnostic criteria and the course of the condition was singled out by many researchers. The evidence from the research on etiological factors was also reviewed, and most authors seem to agree on a nature-nurture interaction model. The different treatment modalities and approaches are also presented and discussed. Finally, a proposal is made for comparative studies to be carried out that will cover course and followup.

Cultural Diversity among American and European Businesspersons.

ERIC Educational Resources Information Center

West, Judy F.; Nixon, Judy C.

An astute American, knowledgeable of and sensitive to cultural diversities among Europeans can communicate effectively for business success. The results of research into the communication customs of 27 European countries are presented: the Big Three (France, Germany, United Kingdom--England, Northern Ireland, Scotland, and Wales); Western…

Why Map Issues? On Controversy Analysis as a Digital Method

PubMed Central

2015-01-01

This article takes stock of recent efforts to implement controversy analysis as a digital method in the study of science, technology, and society (STS) and beyond and outlines a distinctive approach to address the problem of digital bias. Digital media technologies exert significant influence on the enactment of controversy in online settings, and this risks undermining the substantive focus of controversy analysis conducted by digital means. To address this problem, I propose a shift in thematic focus from controversy analysis to issue mapping. The article begins by distinguishing between three broad frameworks that currently guide the development of controversy analysis as a digital method, namely, demarcationist, discursive, and empiricist. Each has been adopted in STS, but only the last one offers a digital “move beyond impartiality.” I demonstrate this approach by analyzing issues of Internet governance with the aid of the social media platform Twitter. PMID:26336325

The chilling effect: how do researchers react to controversy?

PubMed

Kempner, Joanna

2008-11-18

Can political controversy have a "chilling effect" on the production of new science? This is a timely concern, given how often American politicians are accused of undermining science for political purposes. Yet little is known about how scientists react to these kinds of controversies. Drawing on interview (n = 30) and survey data (n = 82), this study examines the reactions of scientists whose National Institutes of Health (NIH)-funded grants were implicated in a highly publicized political controversy. Critics charged that these grants were "a waste of taxpayer money." The NIH defended each grant and no funding was rescinded. Nevertheless, this study finds that many of the scientists whose grants were criticized now engage in self-censorship. About half of the sample said that they now remove potentially controversial words from their grant and a quarter reported eliminating entire topics from their research agendas. Four researchers reportedly chose to move into more secure positions entirely, either outside academia or in jobs that guaranteed salaries. About 10% of the group reported that this controversy strengthened their commitment to complete their research and disseminate it widely. These findings provide evidence that political controversies can shape what scientists choose to study. Debates about the politics of science usually focus on the direct suppression, distortion, and manipulation of scientific results. This study suggests that scholars must also examine how scientists may self-censor in response to political events.

The Chilling Effect: How Do Researchers React to Controversy?

PubMed Central

Kempner, Joanna

2008-01-01

Background Can political controversy have a “chilling effect” on the production of new science? This is a timely concern, given how often American politicians are accused of undermining science for political purposes. Yet little is known about how scientists react to these kinds of controversies. Methods and Findings Drawing on interview (n = 30) and survey data (n = 82), this study examines the reactions of scientists whose National Institutes of Health (NIH)-funded grants were implicated in a highly publicized political controversy. Critics charged that these grants were “a waste of taxpayer money.” The NIH defended each grant and no funding was rescinded. Nevertheless, this study finds that many of the scientists whose grants were criticized now engage in self-censorship. About half of the sample said that they now remove potentially controversial words from their grant and a quarter reported eliminating entire topics from their research agendas. Four researchers reportedly chose to move into more secure positions entirely, either outside academia or in jobs that guaranteed salaries. About 10% of the group reported that this controversy strengthened their commitment to complete their research and disseminate it widely. Conclusions These findings provide evidence that political controversies can shape what scientists choose to study. Debates about the politics of science usually focus on the direct suppression, distortion, and manipulation of scientific results. This study suggests that scholars must also examine how scientists may self-censor in response to political events. PMID:19018657

Controversies in neonatal resuscitation.

PubMed

Chalkias, Athanasios; Xanthos, Theodoros; Syggelou, Angeliki; Bassareo, Pier Paolo; Iacovidou, Nicoletta

2013-10-01

Despite recent advances in perinatal medicine and in the art of neonatal resuscitation, resuscitation strategy and treatment methods in the delivery room should be individualized depending on the unique characteristics of the neonate. The constantly increasing evidence has resulted in significant treatment controversies, which need to be resolved with further clinical and experimental research.

The bellerophont controversy revisited

USGS Publications Warehouse

Harper, J.A.; Rollins, H.B.

2000-01-01

An old controversy reestablished itself in the late 1970s and early 1980s that focused on the systematic placement of the enigmatic Bellerophontoidea (informally, "bellerophonts"), a group of planispirally coiled, wholly fossil molluscs. The controversy embraced three fundamental concepts that are based on different philosophical interpretations of shell form, muscle scar patterns, and other preserved shell features: 1) all bellerophonts were monoplacophorans; 2) all bellerophonts were gastropods; and 3) some bellerophonts were monoplacophorans and some were gastropods. A review of the main issues appearing in the literature since the early 1980s indicates that these three philosophical divisions still exist and, indeed, have become entrenched. An examination of the relevant anatomical and shell features of recent gastropods and monoplacophorans, and comparison with preserved features in enigmatic fossil forms, convinces us that the bellerophontoideans and the coiled and high-domed "monoplacophorans" (Cyclomya) were gastropods. Only the flattened, spoon-and cap-shaped monoplacophorans (Tergomya) were true monoplacophorans. We present a hypothetical scheme for the morphological diversification of gastropods from early monoplacophorans that could account for Cyclomya, Bellerophontoidea, Patellogastropoda, and Prosobranchia.

European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay.

PubMed

Krintus, Magdalena; Kozinski, Marek; Boudry, Pascal; Capell, Nuria Estañ; Köller, Ursula; Lackner, Karl; Lefèvre, Guillaume; Lennartz, Lieselotte; Lotz, Johannes; Herranz, Antonio Mora; Nybo, Mads; Plebani, Mario; Sandberg, Maria B; Schratzberger, Wolfgang; Shih, Jessie; Skadberg, Øyvind; Chargui, Ahmed Taoufik; Zaninotto, Martina; Sypniewska, Grazyna

2014-11-01

International recommendations highlight the superior value of cardiac troponins (cTns) for early diagnosis of myocardial infarction along with analytical requirements of improved precision and detectability. In this multicenter study, we investigated the analytical performance of a new high sensitive cardiac troponin I (hs-cTnI) assay and its 99th percentile upper reference limit (URL). Laboratories from nine European countries evaluated the ARCHITECT STAT high sensitive troponin I (hs-TnI) immunoassay on the ARCHITECT i2000SR/i1000SR immunoanalyzers. Imprecision, limit of blank (LoB), limit of detection (LoD), limit of quantitation (LoQ) linearity of dilution, interferences, sample type, method comparisons, and 99th percentile URLs were evaluated in this study. Total imprecision of 3.3%-8.9%, 2.0%-3.5% and 1.5%-5.2% was determined for the low, medium and high controls, respectively. The lowest cTnI concentration corresponding to a total CV of 10% was 5.6 ng/L. Common interferences, sample dilution and carryover did not affect the hs-cTnI results. Slight, but statistically significant, differences with sample type were found. Concordance between the investigated hs-cTnI assay and contemporary cTnI assay at 99th percentile cut-off was found to be 95%. TnI was detectable in 75% and 57% of the apparently healthy population using the lower (1.1 ng/L) and upper (1.9 ng/L) limit of the LoD range provided by the ARCHITECT STAT hs-TnI package insert, respectively. The 99th percentile values were gender dependent. The new ARCHITECT STAT hs-TnI assay with improved analytical features meets the criteria of high sensitive Tn test and will be a valuable diagnostic tool.

Controversial Science and the Media

NASA Astrophysics Data System (ADS)

Riordon, James

2012-02-01

The possibility that the OPERA collaboration has detected superluminal neutrinos was among the most controversial topics in physics news in decades, and one of the most widely covered stories in all of science in 2011. Word of the research initially reached journalists and the public prior to publication in peer-reviewed journals. Understandably, many physicists are concerned that the significance of controversial science may be exaggerated or distorted when news organizations report on science at such an early stage. I will offer an overview of the ways the story was promoted by the media relations personnel, and outline the rationales that motivate media relations efforts along with the associated benefits and drawbacks that can result. Finally, I will examine the accuracy and completeness of the superluminal neutrino news stories that ultimately were made available to the general public.

Controversial Science and the Media

NASA Astrophysics Data System (ADS)

Riordon, James

2012-03-01

The possibility that the OPERA collaboration has detected superluminal neutrinos was among the most controversial topics in physics news in decades, and one of the most widely covered stories in all of science in 2011. Word of the research initially reached journalists and the public prior to publication in peer-reviewed journals. Understandably, many physicists are concerned that the significance of controversial science may be exaggerated or distorted when news organizations report on science at such an early stage. I will offer an overview of the ways the story was promoted by the media relations personnel, and outline the rationales that motivate media relations efforts along with the associated benefits and drawbacks that can result. Finally, I will examine the accuracy and completeness of the superluminal neutrino news stories that ultimately were made available to the general public.

Medical Device Regulation: A Comparison of the United States and the European Union.

PubMed

Maak, Travis G; Wylie, James D

2016-08-01

Medical device regulation is a controversial topic in both the United States and the European Union. Many physicians and innovators in the United States cite a restrictive US FDA regulatory process as the reason for earlier and more rapid clinical advances in Europe. The FDA approval process mandates that a device be proved efficacious compared with a control or be substantially equivalent to a predicate device, whereas the European Union approval process mandates that the device perform its intended function. Stringent, peer-reviewed safety data have not been reported. However, after recent high-profile device failures, political pressure in both the United States and the European Union has favored more restrictive approval processes. Substantial reforms of the European Union process within the next 5 to 10 years will result in a more stringent approach to device regulation, similar to that of the FDA. Changes in the FDA regulatory process have been suggested but are not imminent.

A Perspective of Controversy in Human Rights Education: A Curricular Proposition

ERIC Educational Resources Information Center

Magendzo, Abraham K.; Pavez, Jorge B.

2017-01-01

This article proposes introducing a strategy of controversy into human rights curriculum. First, it refers to the development of human rights education in Latin America and illustrates how controversy can be incorporated in the different disciplines of the curriculum. Second, the article shows how human rights from a controversial perspective can…

Teaching Controversial Topics in the Humanities and Social Sciences in Ireland: Using Structured Academic Controversy to Develop Multi-Perspectivity in the Learner

ERIC Educational Resources Information Center

Bruen, Jennifer; Crosbie, Veronica; Kelly, Niamh; Loftus, Maria; Maillot, Agnès; McGillicuddy, Áine; Péchenart, Juliette

2016-01-01

Purpose: This study had two main objectives: The first was to explore the extent to which a group of University lecturers feel that they are prepared to deal with controversial issues in their classrooms. The second was to elicit their views on a didactic approach known as Structured Academic Controversy (SAC). SAC is a constructivist teaching…

16 CFR 2.3 - Policy as to private controversies.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Policy as to private controversies. 2.3 Section 2.3 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE... other action when the alleged violation of law is merely a matter of private controversy and does not...

Implants and Ethnocide: Learning from the Cochlear Implant Controversy

ERIC Educational Resources Information Center

Sparrow, Robert

2010-01-01

This paper uses the fictional case of the "Babel fish" to explore and illustrate the issues involved in the controversy about the use of cochlear implants in prelinguistically deaf children. Analysis of this controversy suggests that the development of genetic tests for deafness poses a serious threat to the continued flourishing of Deaf…

An Assessment of the Quality of Life in the European Union Based on the Social Indicators Approach

ERIC Educational Resources Information Center

Grasso, Marco; Canova, Luciano

2008-01-01

This article carries out a multidimensional analysis of welfare based on the social indicators approach aimed at assessing the quality of life in the 25 member countries of the European Union. It begins with description of the social indicators approach and provides some specifications on its most controversial points. It then specifies the…

Drug Testing: A National Controversy.

ERIC Educational Resources Information Center

Stone, Karen; Thompson, Judith R.

1989-01-01

Addresses some of the controversies and illustrates the historical background of drug testing and what the different drug tests are. Also outlines some national statistics and opinions on drug testing and the results of a survey taken of a Louisiana population dealing with this issue. (NB)

Controversial Issues in Learning Disability.

ERIC Educational Resources Information Center

Sapir, Selma C.

The author discusses controversial issues in the field of learning disabilities (LD). Among topics addressed are conflicting definitions of LD and the impact of the operational definition accepted by the US Government; etiological questions concerning the separation of neurological, environmental, and emotional factors; approaches used in training…

Patch testing: facts and controversies.

PubMed

Wolf, Ronni; Orion, Edith; Ruocco, Vincenzo; Baroni, Adone; Ruocco, Eleonora

2013-01-01

The German dermatologist, Josef Jadassohn (1863-1936), first presented the results of his innovative patch-testing technique in 1895. The safety and efficacy of this diagnostic tool has stood the test of time and is still the gold standard for the diagnosis of allergic contact dermatitis (ACD). Since its discovery, much effort has been put into standardization and optimization of allergens, vehicles, and concentrations of patch-test materials; in procedures of its application; and in reading and scoring of test reactions--all contributing to the development of an accurate, reliable, and safe test with a high reproducibility of its results. Even this seemingly carved-in-stone practice, which has been used for nearly 120 years, has been questioned and challenged, engendering debates, disagreements, and controversies, which show no signs of coming to an end. Almost every step of the procedure has provoked discussions and controversies: Copyright © 2013 Elsevier Inc. All rights reserved.

Towards a European code of medical ethics. Ethical and legal issues.

PubMed

Patuzzo, Sara; Pulice, Elisabetta

2017-01-01

The feasibility of a common European code of medical ethics is discussed, with consideration and evaluation of the difficulties such a project is going to face, from both the legal and ethical points of view. On the one hand, the analysis will underline the limits of a common European code of medical ethics as an instrument for harmonising national professional rules in the European context; on the other hand, we will highlight some of the potentials of this project, which could be increased and strengthened through a proper rulemaking process and through adequate and careful choice of content. We will also stress specific elements and devices that should be taken into consideration during the establishment of the code, from both procedural and content perspectives. Regarding methodological issues, the limits and potentialities of a common European code of medical ethics will be analysed from an ethical point of view and then from a legal perspective. The aim of this paper is to clarify the framework for the potential but controversial role of the code in the European context, showing the difficulties in enforcing and harmonising national ethical rules into a European code of medical ethics. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

What price politics? Scientists and political controversy.

PubMed

Nye, M J

1999-01-01

There is a long tradition within scientific communities that encourages governments, patrons and citizens to enlist scientific expertise in the service of the public good. However, since the 17th century, scientists who have engaged in public political controversy have often been judged harshly by scientific colleagues, as well as by political adversaries. Some prominent scientists were politically active in Germany, France and England during the 1920s and 1930s; controversial stands were taken by the British physicist P.M.S. Blackett and the American chemist Linus C. Pauling against their countries' nuclear weapons policy following the Second World War.

Controversies and consensus in the innovation access for cancer therapy in the European countries: on the subject of metastatic prostate cancer.

PubMed

Oudard, S; Courbon, F

2017-02-01

Innovative cancer therapies and advances in drug development have created new hopes for patients and health providers. The purpose of this article was to evaluate the discrepancies in the assessment of the magnitude of benefit of four new drugs (abiraterone acetate, enzalutamide, cabazitaxel, radium-223 dichloride) for the treatment of metastatic castration-resistant prostate cancer (mCRPC). The comparison was done among three European countries (UK, Germany and France) and Canada, according to the statement of each country and to the European Society of Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale. Whereas those drugs are authorized by the European Medical Agency, one can observed that clear discrepancies in the magnitude of benefit assessment exist between selected countries, as well as between national pricing evaluation agencies and ESMO. However, price setting and reimbursement decisions remain national responsibility with differences in assessment of the medical value of new treatment across countries, leading to a heterogeneous accessibility to cancer treatments. In conclusion, several procedures have to be implemented to overcome the patchwork of administrative assessments. Among them, the assessment of medical value should be based on independent statements of learned societies, and the harmonization of access to cancer therapy in Europe has to be driven by a common European reimbursement and pricing policy. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Darwinian Controversies: An Historiographical Recounting

ERIC Educational Resources Information Center

Depew, David J.

2010-01-01

This essay reviews key controversies in the history of the Darwinian research tradition: the Wilberforce-Huxley debate in 1860, early twentieth-century debates about the heritability of acquired characteristics and the consistency of Mendelian genetics with natural selection; the 1925 Scopes trial about teaching evolution; tensions about race,…

Women's Athletics: Coping with Controversy.

ERIC Educational Resources Information Center

Hoepner, Barbara J., Ed.

This book is a collection of papers discussing controversial topics in women's athletics. Section one, "Overview--Women's Rights," includes articles on women's rights and equal opportunities in sports, the emergence of women in sports, and significant events in a century of American women's sports. Section two, "Women's Intercollegiate…

The design of an enzyme: a chronology on the controversy.

PubMed

Buc, Henri

2013-05-13

After the publication of the Monod-Wyman-Changeux model, a controversy arose between Jacques Monod, Francis Crick and Jeffries Wyman about the comparison of the regulatory performances of an oligomer undergoing a concerted transition between two states and a monomer having the same composition and subjected to a similar conformational equilibrium. The controversy took place between September 1965 and March 1966. It gave rise to several unpublished notes. Numerous misunderstandings between the participants were not fully dissipated as the controversy abruptly ended. Copyright © 2013 Elsevier Ltd. All rights reserved.

The European VLBI network

NASA Technical Reports Server (NTRS)

Schilizzi, R. T.

1980-01-01

The capabilities of the European very long baseline interferometry (VLBI) network are summarized. The range of baseline parameters, sensitivities, and recording and other equipment available are included. Plans for upgrading the recording facilities and the use of geostationary satellites for signal transfer and clock synchronization are discussed.

The Rasch Rating Model and the Disordered Threshold Controversy

ERIC Educational Resources Information Center

Adams, Raymond J.; Wu, Margaret L.; Wilson, Mark

2012-01-01

The Rasch rating (or partial credit) model is a widely applied item response model that is used to model ordinal observed variables that are assumed to collectively reflect a common latent variable. In the application of the model there is considerable controversy surrounding the assessment of fit. This controversy is most notable when the set of…

The Cretaceous/Tertiary Extinction Controversy Reconsidered.

ERIC Educational Resources Information Center

McCartney, Kevin; Nienstedt, Jeffrey

1986-01-01

Reviews varying positions taken in the Cretaceous/Tertiary (K/Y) extinction controversy. Analyzes and contests the meteoritic impact theory known as the Alvarez Model. Presents an alternative working hypothesis explaining the K/T transition. (ML)

Comparative sensitivity of European native (Anodonta anatina) and exotic (Corbicula fluminea) bivalves to mercury

NASA Astrophysics Data System (ADS)

Oliveira, Patrícia; Lopes-Lima, Manuel; Machado, Jorge; Guilhermino, Lúcia

2015-12-01

Pollution is believed to be an important factor modulating the competition between exotic invasive bivalves and their native competitors. Thus, the objective of the present study was to compare the sensitivity of the European native Anodonta anatina and the exotic invasive species Corbicula fluminea to mercury, a ubiquitous environmental contaminant of high concern. In laboratory acute bioassays, adult organisms of both species were exposed independently to mercury for 96 h (31-500 μg/L). The criteria indicative of toxicity were mortality and biomarkers of oxidative stress and damage, neurotoxicity, and energy production changes. Mercury induced mortality in A. anatina (72 h-LC10 and 72 h-LC50 of 14.0 μg/L and 49.6 μg/L, respectively) but not in C. fluminea. The ability of C. fluminea to maintaining the shell closed for considerable periods of time when exposed to high concentrations of mercury and the effective activation (up to 63 μg/L) of mechanisms against the oxidative stress caused by mercury may have contributed to its relatively low sensitivity. In the range of concentrations tested, mercury had no significant effects on the other parameters analysed in C. fluminea. Overall, the findings of the present study, suggest that in real scenarios of competition between C. fluminea and A. anatina populations, the presence of mercury may modulate the process, acting in favour of the exotic species because it is less sensitive to this environmental contaminant than the native bivalve. The results of the present study highlight the need of further investigation on the effects of mercury on the competition between exotic invasive species and their native competitors, especially the effects potentially induced by long-term exposure to low concentrations of this metal, the mechanisms involved in the tolerance to mercury-induced stress, and the potential post-exposure recovery of both exotic invasive and native bivalves. This knowledge is most important for

Controversial Curriculum? Ask the Community!

ERIC Educational Resources Information Center

Davis, William Jeffrey

2009-01-01

Involving communities in the process of curriculum development may not be novel, but it seems lacking with regard to controversial issues such as lessons on diverse family structures, homosexuality, and other special situations. Disparity in values and convictions can lead one person to support a decision, while another person might hold an…

Eliminating Racism: Profiles in Controversy.

ERIC Educational Resources Information Center

Katz, Phyllis A., Ed.; Taylor, Dalmas A., Ed.

Dialogue and research on racism since the mid-1970s have yielded increased controversy over the theories, foundation, and continued existence of racism. The chapters presented in this book provide various divergent views of what constitutes racism and frameworks for reducing it. The following chapters (and their authors) are included: (1)…

Age determination of unaccompanied asylum seeking minors in the European Union: a health law perspective.

PubMed

Abbing, Henriette D C Roscam

2011-01-01

In the European Union, unaccompanied asylum seekers below 18 years of age are entitled to specific treatment. Age assessment practices to verify the age-statement by the asylum seeker differ between EU Member States. Medical methods in use raise questions about accuracy, reliability and safety. The medical, legal and ethical acceptability of invasive methods (notably X-rays) in particular is controversial. Human rights are at stake. The lack of common practices results in different levels of protection (discrimination). The absence ofstandardisation is an obstacle for the functioning of the Common European Asylum System. EU Best Practice Guidelines should remedy the situation; such guidelines should reflect the best interest of the child.

Weak value controversy

NASA Astrophysics Data System (ADS)

Vaidman, L.

2017-10-01

Recent controversy regarding the meaning and usefulness of weak values is reviewed. It is argued that in spite of recent statistical arguments by Ferrie and Combes, experiments with anomalous weak values provide useful amplification techniques for precision measurements of small effects in many realistic situations. The statistical nature of weak values is questioned. Although measuring weak values requires an ensemble, it is argued that the weak value, similarly to an eigenvalue, is a property of a single pre- and post-selected quantum system. This article is part of the themed issue `Second quantum revolution: foundational questions'.

Teaching Controversial Issues of Bioethics.

ERIC Educational Resources Information Center

Stronck, David R.

Many teachers avoid controversial topics because they do not want to upset students or parents, do not know appropriate instructional strategies, and fail to recognize the importance of motivating students through placing science in its relevant context. An example is provided for use in a methods course for helping future high school teachers to…

Embracing Controversy in the Classroom

ERIC Educational Resources Information Center

Cannard, Kelly

2005-01-01

Discussing controversial topics such as stem cell research is a great way for students to build scientific understanding, enhance communication skills, and develop an appreciation for civic decision making. Tackling a topic such as stem cells at the middle level, however, can be a challenge because most young adolescents see the world in black and…

42 CFR 405.817 - Principles for determining amount in controversy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Principles for determining amount in controversy... the Medicare Part B Program § 405.817 Principles for determining amount in controversy. (a) Individual... may assert that the aggregation principles contained in this subpart may be applied to determine the...

Preparing Students for Science in the Face of Social Controversy

ERIC Educational Resources Information Center

Bramschreiber, Terry; Westmoreland, David

2015-01-01

Science educators often teach topics that are largely resolved in the scientific community yet remain controversial in broader society. In such cases, students may perceive the teacher as biased. We present two exercises that foster more objective learning about the scientific underpinnings of socially controversial topics. The first exercise…

Controversial Issues in United States History Classrooms: Teachers' Perspectives

ERIC Educational Resources Information Center

Nichols-Cocke, Cathy

2014-01-01

The purpose of this study was to understand how secondary level United States History teachers approached controversial issues in their standards-based, high-stakes testing classrooms. Controversial issues consisted of multiple points of view, were socially constructed, and had the potential to challenge belief systems. The audience and their…

Sorting Out the Video Game Controversy.

ERIC Educational Resources Information Center

Crespi, Pam

1983-01-01

This article looks at the controversy over video games; arguments for and against them are offered, along with a list of regulations in force around the country and nine important factors agencies should consider before leasing the machines. (JM)

Controversial Texts and Public Education.

ERIC Educational Resources Information Center

Smith, David L.

Because public schools are designed to serve the widest range of interests and are committed to the ideal of democracy, teachers cannot afford to avoid teaching works or presenting ideas that offend some members of communities. Students need to learn the value of controversy and of the challenges posed by a text. Richard Wright's "Native Son" and…

Controversies in Pediatric Sports Medicine (Commentary).

ERIC Educational Resources Information Center

Dyment, Paul G.

1989-01-01

Discusses controversial issues that have arisen in children's sports, including infant exercise programs, trampolines, amenorrhea in the adolescent athlete, coed contact sports, and sport participation by children with Down Syndrome. Policy statements are included from the American Academy of Pediatrics. (JD)

Causes of oral cancer--an appraisal of controversies.

PubMed

Warnakulasuriya, S

2009-11-28

Major risk factors for oral cancer are cigarette smoking and alcohol misuse. Among Asian populations, regular use of betel quid (with or without added tobacco) increases oral cancer risks. Dentists should be aware of some emerging risk factors for oral, and particularly oropharyngeal cancer such as the role of the human papillomavirus infection (HPV). Decreases in risk could be achieved by encouraging high fruit and vegetable consumption. Some controversies related to the aetiology of this disease also need clarification. The objective of this paper is to provide an opinion on these debated controversies.

Sexual and reproductive rights and the human rights agenda: controversial and contested.

PubMed

Nowicka, Wanda

2011-11-01

In this paper I share some of my experience and observations, as an advocate for women's rights, of the last 20 years of struggles for sexual and reproductive health and rights, carried out in many key places where these issues have been debated and decided. I do not aspire to be comprehensive about the current status of human rights related to sexuality and reproduction. Given that my expertise is of a practical (rather than theoretical) nature, the complexity of the topic and contradictory events with regard to it, which take place almost everyday, I will highlight some selected achievements and setbacks in this area, particularly regarding abortion rights. I will provide examples of how human rights related to sexual and reproductive health have been addressed in UN policy-setting bodies, such as the Commission on the Status of Women and Commission on Population and Development, as well as in the UN human rights system such as Treaty Monitoring Bodies and Human Rights Council. Given my work with European institutions, I provide examples of important decisions by the Council of Europe and the European Court of Human Rights. Lastly, I discuss growing opposition to a progressive human rights agenda and the universality of human rights. Despite significant successes, sexual and reproductive rights will long remain controversial and contested. Hence, it is crucial to try to find new ways to engage and new partners to work with. Copyright © 2011 Reproductive Health Matters. Published by Elsevier Ltd. All rights reserved.

Sugar consumption, metabolic disease and obesity: The state of the controversy.

PubMed

Stanhope, Kimber L

2016-01-01

The impact of sugar consumption on health continues to be a controversial topic. The objective of this review is to discuss the evidence and lack of evidence that allows the controversy to continue, and why resolution of the controversy is important. There are plausible mechanisms and research evidence that supports the suggestion that consumption of excess sugar promotes the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) both directly and indirectly. The direct pathway involves the unregulated hepatic uptake and metabolism of fructose, leading to liver lipid accumulation, dyslipidemia, decreased insulin sensitivity and increased uric acid levels. The epidemiological data suggest that these direct effects of fructose are pertinent to the consumption of the fructose-containing sugars, sucrose and high fructose corn syrup (HFCS), which are the predominant added sugars. Consumption of added sugar is associated with development and/or prevalence of fatty liver, dyslipidemia, insulin resistance, hyperuricemia, CVD and T2DM, often independent of body weight gain or total energy intake. There are diet intervention studies in which human subjects exhibited increased circulating lipids and decreased insulin sensitivity when consuming high sugar compared with control diets. Most recently, our group has reported that supplementing the ad libitum diets of young adults with beverages containing 0%, 10%, 17.5% or 25% of daily energy requirement (Ereq) as HFCS increased lipid/lipoprotein risk factors for CVD and uric acid in a dose-response manner. However, un-confounded studies conducted in healthy humans under a controlled, energy-balanced diet protocol that enables determination of the effects of sugar with diets that do not allow for body weight gain are lacking. Furthermore, recent reports conclude that there are no adverse effects of consuming beverages containing up to 30% Ereq sucrose or HFCS, and the conclusions from several meta-analyses suggest

Sugar consumption, metabolic disease and obesity: The state of the controversy

PubMed Central

Stanhope, Kimber L.

2016-01-01

The impact of sugar consumption on health continues to be a controversial topic. The objective of this review is to discuss the evidence and lack of evidence that allows the controversy to continue, and why resolution of the controversy is important. There are plausible mechanisms and research evidence that support the suggestion that consumption of excess sugar promotes the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) both directly and indirectly. The direct pathway involves the unregulated hepatic uptake and metabolism of fructose, which leads to liver lipid accumulation, dyslipidemia, decreased insulin sensitivity and increased uric acid levels. The epidemiological data suggest that these direct effects of fructose are pertinent to the consumption of the fructose-containing sugars, sucrose and HFCS, which are the predominant added sugars. Consumption of added sugar is associated with development and/or prevalence of fatty liver, dyslipidemia, insulin resistance, hyperuricemia, cardiovascular disease and type 2 diabetes, and many of these associations are independent of body weight gain or total energy intake. There are diet intervention studies in which human subjects exhibited increased circulating lipids and decreased insulin sensitivity when consuming high sugar compared with control diets. Most recently, our group has reported that supplementing the ad libitum diets of young adults with beverages containing 0, 10, 17.5 or 25% of daily energy requirement (Ereq) as high fructose corn syrup (HFCS) increased lipid/lipoprotein risk factors for cardiovascular disease (CVD) and uric acid in a dose response manner. However, un-confounded studies conducted in healthy humans under a controlled, energy-balanced diet protocol that allow determination of the effects of sugar with diets that do not allow for body weight gain are lacking. Furthermore, there are recent reports that conclude that there are no adverse effects of consuming beverages

From Classroom to Controversy: Conflict in the Teaching of Religion

ERIC Educational Resources Information Center

Neal, Lynn S.

2013-01-01

What happens when a class assignment becomes a source of controversy? How do we respond? What do we learn? By describing the controversy surrounding an assignment on religion and representation, this article examines conflict's productive role in teaching about New Religious Movements (NRMs) and religion. It suggests that we consider how our…

Zollinger-Ellison syndrome: past, present and future controversies.

PubMed Central

Jensen, R. T.

1994-01-01

It is fitting that the Zollinger-Ellison syndrome (ZES) be included in the Lester Dragstedt Symposium because Dr. Dragstedt had a long-time interest in this disease, having been one of the five discussants of the original article and subsequently reporting with Dr. Oberhelman on nine cases. The approach to therapy of ZES has been controversial from the beginning, and a number of controversies remain. In this article, four different controversies are analyzed from the prospective of the past (Zollinger-Dragstedt era, 1955-1980), present and what may happen in the future in light of recent results. Specifically analyzed are: 1) the role of gastric surgery in the management; 2) whether gastrinoma removal without aggressive resection in patients with ZES without MEN-I is the preferred surgical therapy; 3) whether patients with MEN-I should undergo routine surgical exploration; and 4) whether most gastrinomas will be localized preoperatively. An analysis of recent advances suggests there may be marked changes in the future from our current and our past approaches. Images Figure 2 PMID:7502529

Tennessee to Texas: Tracing the Evolution Controversy in Public Education

ERIC Educational Resources Information Center

Armenta, Tony; Lane, Kenneth E.

2010-01-01

Darwin's Theory of Evolution has stirred controversy since its inception. Public schools in the United States, pressed by special interest groups on both sides of the controversy, have struggled with how best to teach the theory, if at all. Court cases have dealt with whether states can ban the teaching of evolutionary theory, whether Creationism…

Improving Learning by Discussing Controversies in 20th Century Physics.

ERIC Educational Resources Information Center

Niaz, Mansoor; Rodriguez, Maria A.

2002-01-01

Textbooks rarely emphasize how controversial some physics theories were at the time of their proposal. Makes the case that useful classroom debate can be generated by considering the controversy that arose over models of the atom such as Rutherford's and Bohr's, and ideas about fractional charges put forward by Millikan and arising from quark…

Sparking controversy: Jean Antoine Nollet and medical electricity south of the Alps.

PubMed

Bertucci, Paola

2005-01-01

The paper considers a significant episode in the history of eighteenth-century electricity: the controversy over the "medicated tubes". Invented by the Italian erudite Gianfrancesco Pivati, the tubes were said to produce instantaneous cures. Jean Antoine Nollet was one of the main actors of the controversy. In 1749, after touring Italy to see for himself the Italian tubes and their effects, he published a report, discrediting Pivati's accounts. This study shows that the report, which has since been the main source for interpretations of the controversy, hides the key role of the Bologna Istituto delle Scienze in promoting Pivati's invention. Relying on manuscript sources, I propose a change of perspective on the controversy that illuminates the world of Italian experimental philosophy during the Enlightenment and its place in the Republic of Letters. I also analyze the reasons for Nollet's silence over the involvement of the Istituto delle Scienze in the controversy and the relevance of medical electricity in the wider context of contemporary electrical experimental philosophy.

Visualizing Social Justice: Using Controversial Images in Social Studies Classrooms

ERIC Educational Resources Information Center

Hawley, Todd S.; Crowe, Alicia R.; Mooney, Evan

2016-01-01

In this article, we promote the use of controversial images to enhance the discussion of social justice issues in schools. Controversial images provide rich opportunities for students to question what is occurring currently in society as well as what has occurred in the past. We provide an example set of activities to be used in teacher education…

Tele-monitoring of ventilator-dependent patients: a European Respiratory Society Statement.

PubMed

Ambrosino, Nicolino; Vitacca, Michele; Dreher, Michael; Isetta, Valentina; Montserrat, Josep M; Tonia, Thomy; Turchetti, Giuseppe; Winck, Joao Carlos; Burgos, Felip; Kampelmacher, Michael; Vagheggini, Guido

2016-09-01

The estimated prevalence of ventilator-dependent individuals in Europe is 6.6 per 100 000 people. The increasing number and costs of these complex patients make present health organisations largely insufficient to face their needs. As a consequence, their burden lays mostly over families. The need to reduce healthcare costs and to increase safety has prompted the development of tele-monitoring for home ventilatory assistance.A European Respiratory Society Task Force produced a literature research based statement on commonly accepted clinical criteria for indications, follow-up, equipment, facilities, legal and economic issues of tele-monitoring of these patients.Many remote health monitoring systems are available, ensuring safety, feasibility, effectiveness, sustainability and flexibility to face different patients' needs. The legal problems associated with tele-monitoring are still controversial. National and European Union (EU) governments should develop guidelines and ethical, legal, regulatory, technical, administrative standards for remote medicine. The economic advantages, if any, of this new approach must be compared to a "gold standard" of home care that is very variable among different European countries and within each European country.Much more research is needed before considering tele-monitoring a real improvement in the management of these patients. Copyright ©ERS 2016.

European trauma guideline compliance assessment: the ETRAUSS study.

PubMed

Hamada, Sophie Rym; Gauss, Tobias; Pann, Jakob; Dünser, Martin; Leone, Marc; Duranteau, Jacques

2015-12-08

Haemorrhagic shock is the leading cause of preventable death in trauma patients. The 2013 European trauma guidelines emphasise a comprehensive, multidisciplinary, protocol-based approach to trauma care. The aim of the present Europe-wide survey was to compare 2015 practice with the 2013 guidelines. A group of members of the Trauma and Emergency Medicine section of the European Society of Intensive Care Medicine developed a 50-item questionnaire based upon the core recommendations of the 2013 guidelines, employing a multistep approach. The questionnaire covered five fields: care structure and organisation, haemodynamic resuscitation targets, fluid management, transfusion and coagulopathy, and haemorrhage control. The sampling used a two-step approach comprising initial purposive sampling of eminent trauma care providers in each European country, followed by snowball sampling of a maximum number of trauma care providers. A total of 296 responses were collected, 243 (81 %) from European countries. Those from outside the European Union were excluded from the analysis. Approximately three-fourths (74 %) of responders were working in a designated trauma centre. Blunt trauma predominated, accounting for more than 90 % of trauma cases. Considerable heterogeneity was observed in all five core aspects of trauma care, along with frequent deviations from the 2013 guidelines. Only 92 (38 %) of responders claimed to comply with the recommended systolic blood pressure target, and only 81 (33 %) responded that they complied with the target pressure in patients with traumatic brain injury. Crystalloid use was predominant (n = 209; 86 %), and vasopressor use was frequent (n = 171, 76 %) but remained controversial. Only 160 respondents (66 %) declared that they used tranexamic acid always or often. This is the first European trauma survey, to our knowledge. Heterogeneity is significant across centres with regard to the clinical protocols for trauma patients and as to locally

Nosema ceranae (Microsporidia), a controversial 21st century honey bee pathogen.

PubMed

Higes, Mariano; Meana, Aránzazu; Bartolomé, Carolina; Botías, Cristina; Martín-Hernández, Raquel

2013-02-01

The worldwide beekeeping sector has been facing a grave threat, with losses up to 100-1000 times greater than those previously reported. Despite the scale of this honey bee mortality, the causes underlying this phenomenon remain unclear, yet they are thought to be multifactorial processes. Nosema ceranae, a microsporidium recently detected in the European bee all over the world, has been implicated in the global phenomenon of colony loss, although its role remains controversial. A review of the current knowledge about this pathogen is presented focussing on discussion related with divergent results, trying to analyse the differences specially based on different methodologies applied and divisive aspects on pathology while considering a biological or veterinarian point of view. For authors, the disease produced by N. ceranae infection cannot be considered a regional problem but rather a global one, as indicated by the wide prevalence of this parasite in multiple hosts. Not only does this type of nosemosis causes a clear pathology on honeybees at both the individual and colony levels, but it also has significant effects on the production of honeybee products. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

30 CFR 282.7 - Jurisdictional controversies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Jurisdictional controversies. 282.7 Section 282.7 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OPERATIONS IN THE OUTER CONTINENTAL SHELF FOR MINERALS OTHER THAN OIL, GAS, AND SULPHUR General § 282.7...

30 CFR 281.9 - Jurisdictional controversies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Jurisdictional controversies. 281.9 Section 281.9 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF General § 281.9 Jurisdictional...

30 CFR 281.9 - Jurisdictional controversies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Jurisdictional controversies. 281.9 Section 281.9 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL...

The ISS Sensitizing Agents Data Bank (BDS).

PubMed

Brunetto, Barbara; Binetti, Roberto; Ceccarelli, Federica; Costamagna, Francesca Marina; D'Angiolini, Antonella; Fabri, Alessandra; Ferri, Maurizio; Marcello, Ida; Riva, Giovanni; Roazzi, Paolo; Trucchi, Daniela; Tinghino, Raffaella

2008-01-01

The Istituto Superiore Sanità has developed a data bank on sensitizing substances (Banca Dati Sensibilizzanti, BDS), available on website (www.iss.it/bdse/), sharing complete, controlled and updated information coming from different sources, such as scientific publications, international agencies and governmental or non governmental organizations. It is worthwhile that the main objective of the BDS is not the classification of sensitizing or potentially sensitizing agents within specific risk classes, but it is essentially to provide concise and non confidential information related to this endpoint. At present, the BDS includes: all the substances officially classified by European Union, (Annex I to Directive 67/548/EEC), some substances listed in I (Directive 67/548/EEC) for endpoints different than "sensitization" but indicated as sensitizers by other relevant institutions, all the substances indicated as sensitizers by relevant agencies or institutions (ACGIH, DFG), some substances indicted as sensitizers by industry and other non-governmental organizations (ETAD and HERA), all the substances regarded as "potentially sensitizing dyes" by the Commission of the European Community for the award of the eco-label to textile products, some substances for which, even in the absence of any categorization by Union, ACGIH or DFG, it is not possible to exclude a sensitizing potential on the basis of reliable documents.

[A European discussion about stem cells for therapeutic use].

PubMed

Boer, G J

2002-06-29

Stem cells as a source material for growing cellular transplants to repair dysfunctional organs appear to be a new challenge for medical science. Though stem cells are also present in foetal and adult organs, embryonic stem cells from the pre-implantation embryo in particular have the potency to proliferate easily in vitro and the capacity to differentiate into all the body's organ-specific cells. Therefore, these are the ideal cells for developing new cell transplantation therapies for diseases such as Parkinson's disease, diabetes mellitus and heart failure. The use of spare in vitro fertilization (IVF) embryos or pre-implantation embryos specially created to harvest human embryonic stem cells is, however, controversial and an ethical problem. In a European discussion platform organised by the European Commission Research Directorate-General, the status quo of the progress was presented and subsequently commented upon and discussed in terms of medical-ethical, social, industrial and patient interests. The expectations of this new medical technology were high, but clinical trials seem only acceptable once the in vitro differentiation of stem cells can be adequately controlled and once it is known how in vitro prepared stem cells behave after implantation. The ethical justification of the use of in vitro pre-implantation embryos remains controversial. The prevailing view is that the interests of severely ill patients for whom no adequate therapy exists, surmounts the interest of protection of a human in vitro pre-implantation embryo, regardless of whether it was the result of IVF or of transplantation of a somatic cell nucleus of the patient in an enucleated donor egg cell (therapeutic cloning).

The breast implant controversy.

PubMed

Cook, R R; Harrison, M C; LeVier, R R

1994-02-01

The breast implant issue is a "bad news/good news" story. For many women with implants, the controversy has caused a fair degree of anxiety which may or may not be resolved as further information becomes available. It has also taken its toll on Dow Corning. Whole lines of medical products have been eliminated or are being phase out. The development of new medical applications has been terminated. As a consequence, employees have lost their jobs. What the effect will be on the biomedical industry as a whole remains to be seen (11). While silicones have been an important component in various medical devices, it is likely that other materials can be used as replacements. However, suppliers of non-silicone materials are also reevaluating their role in this market. For example, Du Pont, the nation's largest chemical company, has determined that the unpredictable and excessive costs of doing business with manufacturers of implantable medical devices no longer justifies the unrestricted sale of standard raw materials into this industry. Other companies are quietly following suit. On the up side, it is possible that the research being driven by this controversy will result in a greater understanding of the immunologic implications of xenobiotics, of the importance of nonbiased observations, of the need for ready access to valid data sets, and of the opportunity for valid scientific information to guide legal decisions. Only time will tell.

Geometric design practices for European roads

DOT National Transportation Integrated Search

2001-06-01

The objective of the scanning tour was to review and document European procedures and practices in roadway geometric design and context-sensitive design, in which a balance is sought between safety and mobility needs and community interests. The U.S....

Parental Voices and Controversies in Autism

ERIC Educational Resources Information Center

Langan, Mary

2011-01-01

Parents of children with autism have played a prominent role in controversies surrounding this condition. Parental voices were critical in challenging the "refrigerator mother" theory and more recently have attracted public attention for claims that autism may be caused by childhood vaccinations and that "unorthodox biomedical" treatments may…

Controversy matters: Impacts of topic and solution controversy on the perceived credibility of a scientist who advocates.

PubMed

Beall, Lindsey; Myers, Teresa A; Kotcher, John E; Vraga, Emily K; Maibach, Edward W

2017-01-01

In this article, we focus on the potential influence of a scientist's advocacy position on the public's perceived credibility of scientists as a whole. Further, we examine how the scientist's solution position (information only, non-controversial, and controversial) affects the public's perception of the scientist's motivation for sharing information about specific issues (flu, marijuana, climate change, severe weather). Finally, we assess how perceived motivations mediate the relationship between solution position and credibility. Using data from a quota sample of American adults obtained by Qualtrics (n = 2,453), we found that in some conditions advocating for a solution positively predicted credibility, while in one condition, it negatively predicted scientist credibility. We also found that the influence of solution position on perceived credibility was mediated by several motivation perceptions; most notably through perception that the scientist was motivated to: (a) serve the public and (b) persuade the public. Further results and implications are discussed.

Controversy matters: Impacts of topic and solution controversy on the perceived credibility of a scientist who advocates

PubMed Central

Myers, Teresa A.; Kotcher, John E.; Vraga, Emily K.; Maibach, Edward W.

2017-01-01

In this article, we focus on the potential influence of a scientist’s advocacy position on the public’s perceived credibility of scientists as a whole. Further, we examine how the scientist’s solution position (information only, non-controversial, and controversial) affects the public’s perception of the scientist’s motivation for sharing information about specific issues (flu, marijuana, climate change, severe weather). Finally, we assess how perceived motivations mediate the relationship between solution position and credibility. Using data from a quota sample of American adults obtained by Qualtrics (n = 2,453), we found that in some conditions advocating for a solution positively predicted credibility, while in one condition, it negatively predicted scientist credibility. We also found that the influence of solution position on perceived credibility was mediated by several motivation perceptions; most notably through perception that the scientist was motivated to: (a) serve the public and (b) persuade the public. Further results and implications are discussed. PMID:29136643

Controversial Issues within Biology: Enriching Biology Teaching.

ERIC Educational Resources Information Center

Van Rooy, Wilhelmina

2000-01-01

Describes the development and implementation of a senior high school biology lesson concerned with organ transplantation. Discusses the teacher's rationale and techniques for using controversial issues in science teaching. (Contains 18 references.) (Author/WRM)

Teaching Controversial Ideas: Implications for Change.

ERIC Educational Resources Information Center

Eisenstein, Herbert S.

1982-01-01

Discusses three controversial ideas in education: Dewey's concept of education as continuous experience; Freire's concept of praxis as a pedagogy of freedom; and Maxine Greene's concern with autonomy and choice. Describes how teachers and education in general could benefit from the integration of these ideas into the teacher education curriculum.…

Deliberating International Science Policy Controversies: Uncertainty and AIDS in South Africa

ERIC Educational Resources Information Center

Paroske, Marcus

2009-01-01

International science policy controversies involve disputes over cultural differences in the assessment of knowledge claims and competing visions of the policy-making process between different nations. This essay analyzes these dynamics in the recent controversy surrounding AIDS policy in South Africa. It develops the notion of an epistemological…

Toward a phylogenetic chronology of ancient Gaulish, Celtic, and Indo-European.

PubMed

Forster, Peter; Toth, Alfred

2003-07-22

Indo-European is the largest and best-documented language family in the world, yet the reconstruction of the Indo-European tree, first proposed in 1863, has remained controversial. Complications may include ascertainment bias when choosing the linguistic data, and disregard for the wave model of 1872 when attempting to reconstruct the tree. Essentially analogous problems were solved in evolutionary genetics by DNA sequencing and phylogenetic network methods, respectively. We now adapt these tools to linguistics, and analyze Indo-European language data, focusing on Celtic and in particular on the ancient Celtic language of Gaul (modern France), by using bilingual Gaulish-Latin inscriptions. Our phylogenetic network reveals an early split of Celtic within Indo-European. Interestingly, the next branching event separates Gaulish (Continental Celtic) from the British (Insular Celtic) languages, with Insular Celtic subsequently splitting into Brythonic (Welsh, Breton) and Goidelic (Irish and Scottish Gaelic). Taken together, the network thus suggests that the Celtic language arrived in the British Isles as a single wave (and then differentiated locally), rather than in the traditional two-wave scenario ("P-Celtic" to Britain and "Q-Celtic" to Ireland). The phylogenetic network furthermore permits the estimation of time in analogy to genetics, and we obtain tentative dates for Indo-European at 8100 BC +/- 1,900 years, and for the arrival of Celtic in Britain at 3200 BC +/- 1,500 years. The phylogenetic method is easily executed by hand and promises to be an informative approach for many problems in historical linguistics.

The Animism Controversy Revisited: A Probability Analysis

ERIC Educational Resources Information Center

Smeets, Paul M.

1973-01-01

Considers methodological issues surrounding the Piaget-Huang controversy. A probability model, based on the difference between the expected and observed animistic and deanimistic responses is applied as an improved technique for the assessment of animism. (DP)

The use of content analysis in the assessment of medical controversies.

PubMed

de Villiers, F P

1991-12-01

Medicine is fraught with controversies, and several strategies have been developed in order to reach rational conclusions. Examples are using more subjects or an improved research design, developing consensus statements or using meta-analysis. An additional strategy is described in this paper. The language content of scientific papers is examined to establish whether the authors use factual (informational) language or emotional appeals (directive language) to convince the reader. This type of content analysis is then applied to a sample controversy. The paper shows that directive language content analysis can be applied effectively to scientific publications to clarify the basis of and reasoning behind some controversies.

Lindane in forestry: a continuing controversy

Treesearch

Thomas W. Koerber

1976-01-01

Use of the chlorinated hydrocarbon insecticide lindane to control bark beetles is controversial. Differences of opinion persist, even among knowledgeable entomologists, on whether use is justified in view of potentially harmful side effects. Effectiveness of lindane treatments, as employed in preventing tree mortality from bark beetles, is also in question. In seven...

Accreditation in Kinesiology: The Process, Criticism and Controversy, and the Future

ERIC Educational Resources Information Center

Templin, Thomas J.; Blankenship, Bonnie Tjeerdsma

2007-01-01

The question of accreditation has been quite controversial in higher education. Some consider accreditation as a necessary "evil" while others reject it outright. It is a process designed to promote quality assurance and improvement in institutions and programs, yet one mired in various issues. While accreditation is controversial in a number of…

Science, Politics, and the IQ Controversy.

ERIC Educational Resources Information Center

Snyderman, Mark; Rothman, Stanley

1986-01-01

The controversy over intelligence testing is more often influenced by political considerations than empirical research. A survey of 1,020 experts found that a majority agree that (1) intelligence can be defined; (2) heredity plays a role in individual and group IQ differences; and (3) intelligence testing in schools should continue at its present…

Apraxia of Speech: Concepts and Controversies

ERIC Educational Resources Information Center

Ziegler, Wolfram; Aichert, Ingrid; Staiger, Anja

2012-01-01

Purpose: This article was written as an editorial to a collection of original articles on apraxia of speech (AOS) in which some of the more recent advancements in the understanding of this syndrome are discussed. It covers controversial issues concerning the theoretical foundations of AOS. Our approach was motivated by a change of perspective on…

Glaciers in Patagonia: Controversy and prospects

NASA Astrophysics Data System (ADS)

Kargel, J. S.; Alho, P.; Buytaert, W.; Célleri, R.; Cogley, J. G.; Dussaillant, A.; Guido, Z.; Haeberli, W.; Harrison, S.; Leonard, G.; Maxwell, A.; Meier, C.; Poveda, G.; Reid, B.; Reynolds, J.; Rodríguez, C. A. Portocarrero; Romero, H.; Schneider, J.

2012-05-01

Lately, glaciers have been subjects of unceasing controversy. Current debate about planned hydroelectric facilities—a US7- to 10-billion megaproject—in a pristine glacierized area of Patagonia, Chile [Romero Toledo et al., 2009; Vince, 2010], has raised anew the matter of how glaciologists and global change experts can contribute their knowledge to civic debates on important issues. There has been greater respect for science in this controversy than in some previous debates over projects that pertain to glaciers, although valid economic motivations again could trump science and drive a solution to the energy supply problem before the associated safety and environmental problems are understood. The connection between glaciers and climate change—both anthropogenic and natural—is fundamental to glaciology and to glaciers' practical importance for water and hydropower resources, agriculture, tourism, mining, natural hazards, ecosystem conservation, and sea level [Buytaert et al., 2010; Glasser et al., 2011]. The conflict between conservation and development can be sharper in glacierized regions than almost anywhere else. Glaciers occur in spectacular natural landscapes, but they also supply prodigious exploitable meltwater.

Controversies in Alzheimer's disease drug development.

PubMed

Cummings, Jeffrey L

2008-08-01

Understanding of the pathophysiological basis of Alzheimer's disease (AD) is increasing rapidly and a variety of potential treatment modalities have emerged based on these improved mechanistic insights. The optimal way of proceeding with disease-modifying drug development remains to be clarified and controversies have emerged regarding the definition of Alzheimer's disease, the participation of mild cognitive impairment patients in clinical trials, the definition of disease modification, the potential impediments to satisfaction from patients receiving disease-modifying therapy, the importance of add-on therapy with symptomatic agents, the optimal clinical trial design to demonstrate disease modification, the best means of minimizing time spent in Phase II of drug development, the potential role of adaptive designs in clinical trials, the use of enrichment designs in clinical trials, the role of biomarkers in clinical trials, the treatment of advanced patients with disease-modifying agents, and distinctions between disease modification and disease prevention. The questions surrounding these issues must be resolved as disease-modifying therapies for AD are advanced. These controversies are framed and potential directions towards resolution described.

Mercury, vaccines, and autism: one controversy, three histories.

PubMed

Baker, Jeffrey P

2008-02-01

The controversy regarding the once widely used mercury-containing preservative thimerosal in childhood vaccines has raised many historical questions that have not been adequately explored. Why was this preservative incorporated in the first place? Was there any real evidence that it caused harm? And how did thimerosal become linked in the public mind to the "autism epidemic"? I examine the origins of the thimerosal controversy and their legacy for the debate that has followed. More specifically, I explore the parallel histories of three factors that converged to create the crisis: vaccine preservatives, mercury poisoning, and autism. An understanding of this history provides important lessons for physicians and policymakers seeking to preserve the public's trust in the nation's vaccine system.

Sensitivity of Earth Wheat Markets to Space Weather: Comparative Analysis based on data from Medieval European Markets

NASA Astrophysics Data System (ADS)

Pustil'Nik, Lev

We consider a problem of the possible influence of unfavorable states of the space weather on agriculture markets through the chain of connections: "space weather"-"earth weather"- "agriculture crops"-"price reaction". We show that new manifestations of "space weather"- "earth weather" relations discovered in the recent time allow revising a wide range of the expected solar-terrestrial connections. In the previous works we proposed possible mechanisms of wheat market reaction on the specific unfavorable states of space weather in the form of price bursts and price asymmetry. We point out that implementation of considered "price reaction scenarios" is possible only for the case of simultaneous realization of several necessary conditions: high sensitivity of local earth weather in the selected region to space weather; the state of "high risk agriculture" in the selected agriculture zone; high sensitivity of agricultural market to a possible deficit of yield. Results of our previous works (I, II), including application of this approach to the Medieval England wheat market (1250-1700) and to the modern USA durum market (1910-1992), showed that connection between wheat price bursts and space weather state in these cases was absolutely real. The aim of the present work is to answer the question why wheat markets in one selected region may be sensitive to a space weather factor, while in other regions wheat markets demonstrate absolutely indifferent reaction on the space weather. For this aim, we consider dependence of sensitivity of wheat markets to space weather as a function of their location in different climatic zones of Europe. We analyze a database of 95 European wheat markets from 14 countries for the 600-year period (1260-1912). We show that the observed sensitivity of wheat markets to space weather effects is controlled, first of all, by a type of predominant climate in different zones of agricultural production. Wheat markets in the Northern and, partly, in

Fluoxetine vs. placebo for the treatment of recurrent vasovagal syncope with anxiety sensitivity.

PubMed

Flevari, Panayota; Leftheriotis, Dionyssios; Repasos, Evangelos; Katsaras, Dimitrios; Katsimardos, Andreas; Lekakis, John

2017-01-01

The optimal medical therapy of patients with vasovagal syncope (VVS) remains controversial. Fluoxetine is effective against anxiety and panic disorders, while its use has shown promising results for VVS. Anxiety sensitivity is a personality trait observed in a considerable proportion of patients with VVS, associated with predisposition to anxiety and panic disorders. Our aim was to examine whether fluoxetine exerts beneficial effects regarding VVS prevention in the subset of patients with anxiety sensitivity. We assessed 106 patients with typical history of recurrent VVS, without other comorbidities, and a diagnostic, positive head-up tilt test. A psychiatric examination ruled out clinical psychiatric disease. Their psychological, stress-related profile was assessed by the Anxiety Sensitivity Index (ASI) questionnaire, a 16-item questionnaire, assessing fear of anxiety-related sensations, previously studied in VVS. Patients scoring positive for ASI (n = 60, 57% of the population) were randomized in a 2:1 fashion to receive either 10-40 mg fluoxetine daily (n = 40) or placebo (n = 20), and were followed-up for 1 year. A significant difference was observed between patients receiving fluoxetine and those with placebo, regarding the distribution of syncope-free time during the study (P < 0.05). A significant difference was also observed between the two groups regarding presyncopal events and the total number of patients who experienced syncope or presyncope during follow-up. Sensitivity to anxiety is a common personality trait in recurrent VVS. Fluoxetine is superior to placebo against syncope in these patients. This drug may be a first-line pharmacological treatment for this difficult-to-treat group. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

Anticipation and Controversy Surround "Superman" Release

ERIC Educational Resources Information Center

Aarons, Dakarai I.

2010-01-01

Well in advance of its official release, the education film "Waiting For Superman" has attracted a level of attention that could make it one of the year's most-watched documentaries--and one of the most controversial among educators, some of whom question its depictions of the American school system and how to improve it. Made by…

Controversy, Trials, and Crime--Oh My!

ERIC Educational Resources Information Center

Rott, Kim

2006-01-01

Teenagers' innate interest with the justice system is one of the reasons that so many high school literary classics teem with criminals, controversial issues, and trials. Novels such as "To Kill a Mockingbird," "A Separate Peace," "The Crucible," and "Twelve Angry Men" feature high-impact trials. In the author's desire to tap into this interest,…

Calcitonin estimation in patients with nodular goiter and its significance for early detection of MTC: european comments to the guidelines of the American Thyroid Association.

PubMed

Elisei, Rossella; Romei, Cristina

2013-03-14

One of the most discussed and controversial issue in the management of thyroid nodules is the need to perform a routine measurement of serum Calcitonin (Ct) in all cases. The American Thyroid Association guidelines do not recommend in favor or against this procedure since they retain that there are not enough evidences that it can determine an advantage to the health outcomes of these patients. This is not the view of many European experts who met in Lisbon in 2009 at the European Thyroid Association-Cancer Research Network meeting to discuss all the still open controversial issues on the management of medullary thyroid cancer patients.This paper is focused on the routine measurement of serum Ct in all patients with thyroid nodule(s): the evidences, the rational and the benefits of this procedure are deeply analysed following the discussion that was done in Lisbon. The conclusions reached at that time are reported in detail.

Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature.

PubMed

Schnuch, Axel; Uter, Wolfgang; Geier, Johannes; Lessmann, Holger; Frosch, Peter J

2007-07-01

To study the frequency of sensitization to 26 fragrances to be labelled according to current European regulation. During 4 periods of 6 months, from 1 January 2003 to 31 December 2004, 26 fragrances were patch tested additionally to the standard series in a total of 21 325 patients; the number of patients tested with each of the fragrances ranged from 1658 to 4238. Hydroxymethylpentylcyclohexene carboxaldehyde (HMPCC) was tested throughout all periods. The following frequencies of sensitization (rates in %, standardized for sex and age) were observed: tree moss (2.4%), HMPCC (2.3), oak moss (2.0), hydroxycitronellal (1.3), isoeugenol (1.1), cinnamic aldehyde (1.0), farnesol (0.9), cinnamic alcohol (0.6), citral (0.6), citronellol (0.5), geraniol (0.4), eugenol (0.4), coumarin (0.4), lilial (0.3), amyl-cinnamic alcohol (0.3), benzyl cinnamate (0.3), benzyl alcohol (0.3), linalool (0.2), methylheptin carbonate (0.2), amyl-cinnamic aldehyde (0.1), hexyl-cinnamic aldehyde (0.1), limonene (0.1), benzyl salicylate (0.1), gamma-methylionon (0.1), benzyl benzoate (0.0), anisyl alcohol (0.0). 1) Substances with higher sensitization frequencies were characterized by a considerable number of '++/+++' reactions. 2) Substances with low sensitization frequencies were characterized by a high number of doubtful/irritant and a low number of stronger (++/+++) reactions. 3) There are obviously fragrances among the 26 which are, with regard to contact allergy, of great, others of minor, and some of no importance at all.

LCA – Unique and Controversial Case Studies

EPA Science Inventory

This session will focus on case studies and applications that have a unique or controversial aspect. Some of the most recent topics that seem to have significant interest include: LCA-based product declarations, LCA-based standards, LCA-based labels, alternative energy, agricul...

Metaphysics for an enlightened public: The controversy over monads in Germany, 1746-1748.

PubMed

Broman, Thomas

2012-03-01

This essay analyzes the controversy that attended the prize essay question on monads proposed by the Berlin Academy of Sciences in 1746. The controversy was first touched off by an anonymous pamphlet published by the mathematician Leonhard Euler, the academy's most well known member, that attacked the doctrine of monads. It peaked with the awarding of the prize to Johann Heinrich Gottlob Justi, whose winning essay closely followed Euler's arguments. This essay discusses the controversy as one instance in a broader quarrel in the German academic community over the suitability of Christian Wolff's philosophy as the foundation for a broad range of academic disciplines, including natural philosophy. It also analyzes the controversy as displaying the central role of the periodical press in the emergent German public sphere.

A new earthworm species within a controversial genus: Eiseniona gerardoi sp. n. (Annelida, Lumbricidae) - description based on morphological and molecular data

PubMed Central

Díaz Cosín, Darío J.; Novo, Marta; Fernández, Rosa; Fernández Marchán, Daniel; Gutiérrez, Mónica

2014-01-01

Abstract The morphological and anatomical simplicity of soil dwelling animals, such as earthworms, has limited the establishment of a robust taxonomy making it sometimes subjective to authors’ criteria. Within this context, integrative approaches including molecular information are becoming more popular to solve the phylogenetic positioning of conflictive taxa. Here we present the description of a new lumbricid species from the region of Extremadura (Spain), Eiseniona gerardoi sp. n. The assignment to this genus is based on both a morphological and a phylogenetic study. The validity of the genus Eiseniona, one of the most controversial within Lumbricidae, is discussed. A synopsis of the differences between the type species and the west-European members of the genus is provided. PMID:24843253

Anxiety Sensitivity: A Missing Piece to the Agoraphobia-without-Panic Puzzle

ERIC Educational Resources Information Center

Hayward, Chris; Wilson, Kimberly A.

2007-01-01

This article reviews the controversy surrounding the diagnosis of agoraphobia without panic attacks and proposes a key role for anxiety sensitivity in explaining agoraphobic avoidance among those who have never experienced panic. Although rare in clinical samples, agoraphobia without panic is commonly observed in population-based surveys,…

Social controversy belongs in the climate science classroom

NASA Astrophysics Data System (ADS)

Walsh, Elizabeth M.; Tsurusaki, Blakely K.

2014-04-01

Scientists, educators and stakeholders are grappling with how to best approach climate change education for diverse audiences, a task made difficult due to persistent social controversy. This Perspective examines how sociocultural learning theories can inform the design and implementation of climate change education experiences for learners with varied understandings of and attitudes towards climate change. The literature demonstrates that explicitly addressing learners' social and community experiences, values and knowledge supports understandings of and increased concern about climate change. Science learning environments that situate climate change in its social context can support conceptual understandings, shift attitudes and increase the participation of diverse communities in responding to climate change. Examples are provided of successful programmes that attend to social dimensions and learners' previous experiences, including experiences of social controversy.

Caffeine controversies.

PubMed

Gentle, Samuel J; Travers, Colm P; Carlo, Waldemar A

2018-04-01

Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction. The purpose of the review is to analyze this dynamic trajectory and discuss controversies that still remain after decades of caffeine use. Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus. The lower rate of death or neurodevelopmental impairment noted at 18-21 months was not statistically different at later timepoints; however, infants in the caffeine group had lower rates of motor impairment at 11-year follow-up. The time of caffeine therapy initiation is now substantially earlier, and doses used are sometimes higher that previously used, but there are limited data to support these practices. Caffeine therapy for apnea of prematurity (AOP) remains one of the pillars of neonatal care, although more evidence to support dosing and timing of initiation and discontinuation are needed.

Debating Diversity: Ethics and Controversial Public Issues

ERIC Educational Resources Information Center

Darr, Christopher R.

2016-01-01

Courses: Ethics, Organizational Communication, Political Communication. Objectives: After completing this unit activity, students should be able to (1) apply multiple ethical perspectives to real-world diversity issues in a debate format, and (2) explain the role of informational and social category diversity in current controversies.

What Can We Learn from Taiwanese Teachers about Teaching Controversial Public Issues?

ERIC Educational Resources Information Center

Hung, Yu-Han

2016-01-01

This study explores how history teachers in Taiwan make curricular decisions while engaging controversial public issues. The main political controversies discussed in Taiwanese society center on the relationship between Taiwan and the People's Republic of China. This study documents how four social studies teachers formulate their curricular…

Controversies in gestational diabetes.

PubMed

Nolan, Christopher J

2011-02-01

Gestational diabetes mellitus (GDM) and controversy are old friends. However, several major studies in the field have clarified some of the main issues. There is now no doubt that hyperglycaemia, at levels less than those that occur in overt diabetes, is associated with adverse pregnancy outcomes, such as large-for-gestational age infants, neonatal hyperinsulinism, neonatal hypoglycaemia and pre-eclampsia. We also have evidence now that a standard approach to GDM with diagnosis at 24-28 weeks, dietary advice, self-monitoring of blood glucose and insulin therapy as needed reduces these adverse perinatal outcomes. Unknown, however, is if this same approach is effective at reducing long-term risks of metabolic syndrome, type 2 diabetes and cardiovascular disease in both the mothers and babies. For example, could our management strategies miss critical time points of fuel-mediated injury to the foetus important for the baby's long-term metabolic health? The implications of a recent international consensus statement on new diagnostic criteria for GDM are discussed, as well as issues relating to the timing of diagnosis. The potential place for a risk calculator for adverse outcomes in GDM pregnancy that takes into account glycaemic and non-glycaemic risk factors is considered. Such a tool could help stratify GDM women to different levels of care. Ongoing issues relating to maternal glycaemic and foetal growth targets, and the use of oral hypoglycaemic agents in GDM are discussed. To resolve some of the remaining controversies, further carefully designed randomised controlled trials in GDM with long-term follow-up of both mothers and babies are necessary. Copyright © 2010 Elsevier Ltd. All rights reserved.

[Addressing the controversy regarding the association between thimerosal-containing vaccines and autism].

PubMed

García-Fernández, Lisset; Hernández, Adrián V; Suárez Moreno, Víctor; Fiestas, Fabián

2013-04-01

Vaccination is one of the most important public health interventions in the reduction childhood morbidity and mortality. Thimerosal is an organic mercury compound used as preservante in multi-dose vials. Often in Peru, there are waves of controversy about the safety of this type of vaccines, mainly arguing that there is an association between them and autism. As a result of these controversies, there have been some voices asking for laws banning thimerosal-containing vaccines, which would have a large impact in costs and the logistic aspects of the public vaccination programs. The aim of this article is to review the literature for the main controversies about thimerosal in vaccines and its supposed association to autism. We made an historical review about these controversies given the available scientific evidence and the statements from important international organizations. We concluded that the current available evidence do not support an association between thimerosal and childhood neurodevelopmental disorders, such as autism.

Controversial role of pets in the development of atopy in children.

PubMed

Fretzayas, Andrew; Kotzia, Doxa; Moustaki, Maria

2013-05-01

Exposure to environmental allergens originating from different sources has been implicated in the sensitization to the respective allergens and development of atopic diseases. Keeping domestic animals is associated with exposure to relevant allergens but there are controversial data whether this exposure promotes or protects from the development of atopy. We herein reviewed the literature regarding the available data for the exposure to pets (cats and/or dogs) and the development of atopy. For this purpose, we searched the PubMed database. This review attempts to answer the following questions that arise from the daily practice and the relevant studies, which are: a) is pet keeping associated with sensitization? b) is there an association between keeping pets and the development of asthma, allergic rhinitis and eczema, and, c) what is the underlying mechanism of any possible protective association? Despite the fact that several studies and meta-analyses have been conducted to explore the role of pets in the development of atopy, there are still conflicting pieces of evidence. It seems that there are different effects depending on the type of pets, the time and duration of exposure, and the genetic background of the individual. Further appropriately designed birth cohort studies are needed to explore whether exposure to relevant allergens from pets promotes or protects from the development of atopy.

Controversy over Student's Art Exhibit at Yale Raises Issues of Academic Freedom

ERIC Educational Resources Information Center

Wilson, Robin

2008-01-01

This article describes the controversy surrounding a Yale University art student, Aliza Shvarts, who told the campus newspaper that she had repeatedly inseminated herself artificially and then induced abortions as part of her senior thesis. The controversy has created massive reverberations throughout academe, especially in the already hotly…

The European politics of animal experimentation: From Victorian Britain to 'Stop Vivisection'.

PubMed

Germain, Pierre-Luc; Chiapperino, Luca; Testa, Giuseppe

2017-08-01

This paper identifies a common political struggle behind debates on the validity and permissibility of animal experimentation, through an analysis of two recent European case studies: the Italian implementation of the European Directive 2010/63/EC regulating the use of animals in science, and the recent European Citizens' Initiative (ECI) 'Stop Vivisection'. Drawing from a historical parallel with Victorian antivivisectionism, we highlight important threads in our case studies that mark the often neglected specificities of debates on animal experimentation. From the representation of the sadistic scientist in the XIX century, to his/her claimed capture by vested interests and evasion of public scrutiny in the contemporary cases, we show that animals are not simply the focus of the debate, but also a privileged locus at which much broader issues are being raised about science, its authority, accountability and potential misalignment with public interest. By highlighting this common socio-political conflict underlying public controversies around animal experimentation, our work prompts the exploration of modes of authority and argumentation that, in establishing the usefulness of animals in science, avoid reenacting the traditional divide between epistemic and political fora. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Risk assessment for marine spills along European coastlines.

PubMed

Fernández-Macho, Javier

2016-12-15

A marine-spill risk index is proposed to measure and compare the relative vulnerability of coastal regions to marine spills in European waters. It is applied to 301 spills in European waters between 1970 and 2014 for 429 Eurostat territorial units and 156 regions in Europe's coasts. The results show a high heterogeneity among European coastal regions with areas, predominantly on the Atlantic coast, with high marine-spill risks. In particular, UK coasts are markedly affected as there are only five non-British coastal territories within the first 25 territorial units most at risk from marine spills. Across countries, European Atlantic countries face highest risks versus coastal countries on other European waters that are relatively safer. The index also shows a tendency of sea currents to have positive dispersal effects leading to smaller risks rather than otherwise. The index may help to design protection policies and reduce the vulnerability of sensitive resources. Copyright © 2016 Elsevier Ltd. All rights reserved.

Myriad and the mass media: the covering of a gene patent controversy.

PubMed

Caulfield, Timothy; Bubela, Tania; Murdoch, C J

2007-12-01

We explore how the print media in four jurisdictions framed the controversy surrounding Myriad Genetic's BRCA patents and consider the possible influence of media on public perceptions and policy reform. We used a broad search strategy to collect newspaper articles from Factiva and Lexis/Nexis on Myriad Genetics and the BRCA gene and identified the main triggers for those articles. We then selected articles on the BRCA gene patents for coding. The coding frame queried the presence or absence of either positive or negative statements about gene patenting and a subjective assessment of the tone of the article. We compared the differences in tone and number of positive and negative statements between jurisdictions (Australia, Canada, United Kingdom, and United States). Myriad Genetic's BRCA1/2 gene patents sparked significant international newspaper coverage in comparison to other stories on gene patenting controversies. Only 55.9% of 143 articles presented a variety of perspectives. The majority of articles (77.6%) had a negative overall tenor; only 6.29% had a positive overall tenor, whereas 16.1% were neutral. There were significant differences in the overall tenor between jurisdictions, with Canadian coverage being overwhelmingly negative in comparison with the other three jurisdictions. The main triggers for news coverage were largely local licensing deals, actions at regional patent offices, and statements and publications by prominent figures. Myriad's patents were largely portrayed as a negative story, except in Utah where Myriad Genetics is located, and as an example of the problems associated with gene patents. The story was primarily framed as a social dilemma that needed to be addressed. In Canada there was a disproportionate level of coverage of the political response to the threat of patent infringement action against government testing laboratories and potential impacts on public health care. In Europe and elsewhere in the United States, the opposition

Empowerment in healthcare policy making: three domains of substantive controversy.

PubMed

Chiapperino, Luca; Tengland, Per-Anders

2015-12-01

This paper distinguishes between the uses of empowerment across different contexts in healthcare policy and health promotion, providing a model for the ethical and political scrutiny of those uses. We argue that the controversies currently engendered by empowerment are better understood by means of a historical distinction between two concepts of empowerment, namely, what we call the radical empowerment approach and the new wave of empowerment. Building on this distinction, we present a research agenda for ethicists and policy makers, highlighting three domains of controversy raised by the new wave of empowerment, namely: (1) the relationship between empowerment and paternalistic interferences on the part of professionals; (2) the evaluative commitment of empowerment strategies to the achievement of health-related goals; and (3) the problems arising from the emphasis on responsibility for health in recent uses of empowerment. Finally, we encourage the explicit theorisation of these moral controversies as a necessary step for the development and implementation of ethically legitimate empowerment processes.

Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer.

PubMed

Beyer, J; Albers, P; Altena, R; Aparicio, J; Bokemeyer, C; Busch, J; Cathomas, R; Cavallin-Stahl, E; Clarke, N W; Claßen, J; Cohn-Cedermark, G; Dahl, A A; Daugaard, G; De Giorgi, U; De Santis, M; De Wit, M; De Wit, R; Dieckmann, K P; Fenner, M; Fizazi, K; Flechon, A; Fossa, S D; Germá Lluch, J R; Gietema, J A; Gillessen, S; Giwercman, A; Hartmann, J T; Heidenreich, A; Hentrich, M; Honecker, F; Horwich, A; Huddart, R A; Kliesch, S; Kollmannsberger, C; Krege, S; Laguna, M P; Looijenga, L H J; Lorch, A; Lotz, J P; Mayer, F; Necchi, A; Nicolai, N; Nuver, J; Oechsle, K; Oldenburg, J; Oosterhuis, J W; Powles, T; Rajpert-De Meyts, E; Rick, O; Rosti, G; Salvioni, R; Schrader, M; Schweyer, S; Sedlmayer, F; Sohaib, A; Souchon, R; Tandstad, T; Winter, C; Wittekind, C

2013-04-01

In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497-513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, ∼50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.

The current revolution in newborn screening: new technology, old controversies.

PubMed

Tarini, Beth A

2007-08-01

Newborn screening has provided a model of a successful public health screening program for the past 40 years. However, the history of newborn screening is not without controversy. Many of these controversies have been rekindled with the introduction of tandem mass spectrometry, a technology that has greatly increased our ability to detect potential disease in asymptomatic newborns. This review highlights the challenges raised by this and future technological advances as we strive to maintain the success of newborn screening in the 21st century.

Controversial Issues and the Teaching of A-Level Biology: Possibilities and Problems.

ERIC Educational Resources Information Center

Van Rooy, Wilhelmina

This thesis focuses on the espoused beliefs, values, and attitudes of experienced A-Level Biology teachers in relation to the teaching of controversial biological issues. Of major interest is the thinking behind what the teachers in this study regard as the possibilities and problems for the teaching of controversial issues given the teaching…

The Catholic School, Controversial Issues and the Laity: A Canadian Research Study

ERIC Educational Resources Information Center

McDonough, Graham

2015-01-01

Catholic schools have an important role in helping cultivate the future adult laity, especially given the continuing numerical decline and ageing of clergy and vowed religious persons. As there is demonstrable plurality among the laity on some issues that are controversial within the Church, however, and receiving and responding to controversy is…

37 CFR 351.3 - Controversy and further proceedings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... participant who has filed a written direct statement. (2) Bad faith inflation of claim. If the Copyright Royalty Judges determine that a participant asserts in bad faith an amount in controversy in excess of $10...

Contemporary management of paraesophaegeal hernias: establishing a European expert consensus.

PubMed

Bonrath, E M; Grantcharov, T P

2015-08-01

The surgical treatment of paraesophageal hernias remains a challenge due to the lack of consensus regarding principles of operative treatment. The objectives of this study were to achieve consensus on key topics through expert opinion using a Delphi methodology. A Delphi survey combined with a face-to-face meeting was conducted. A panel of European experts in foregut surgery from high-volume centres generated items in the first survey round. In subsequent rounds, the panel rated agreement with statements on a 5-point Likert-type scale. Internal consistency (consensus) was predefined as Cronbach's α > .80. Items that >70 % of the panel either rated as irrelevant/unimportant, or relevant/important were selected as consensus items, while topics that did not reach this cut-off were termed "undecided/controversial". Three survey rounds were completed: 19 experts from 10 countries completed round one, 18 continued through rounds two and three. Internal consistency was high in rounds two and three (α > .90). Fifty-eight additional/revised items derived from comments and free-text entries were included in round three. In total, 118 items were rated; consensus agreement was achieved for 70 of these. Examples of consensus topics are the relevance of the disease profile for assessing surgical urgency and complexity, the role of clinical history as the mainstay of patient follow-up, indications for revision surgery, and training and credentialing recommendations. Topics with the most "undecided/controversial" items were follow-up, postoperative care and surgical technique. This Delphi study achieved expert consensus on key topics in the operative management of paraesophageal hernias, providing an overview of the current opinion among European foregut surgeons. Moreover, areas with substantial variability in opinions were identified reflecting the current lack of empirical evidence and opportunities for future research.

Controversial Issues in Our Schools. Fastback 146.

ERIC Educational Resources Information Center

Goldstein, William

There is virtually nothing taught in the American public school that is not potentially explosive at some time or place. America's cultural makeup provides for the development of controversy whenever such issues as sex, religion, politics, and economics are raised, and particularly when they are raised in the school environment. School…

The Controversy on National Standards for History.

ERIC Educational Resources Information Center

Chapin, June R.

This paper examines the controversy generated by the 1994 release of the "National Standards for United States History: Exploring the American Experience (5-12)" and "National Standards for World History: Exploring Paths to the Present (5-12)." The standards engendered protests as conservatives and others charged that it was a "politically…

Two decades of p-phenylenediamine and toluene-2,5-diamine patch testing - focus on co-sensitizations in the European baseline series and cross-reactions with chemically related substances.

PubMed

Vogel, Tatiana A; Heijnen, Rakita W; Coenraads, Pieter-Jan; Schuttelaar, Marie-Louise A

2017-02-01

Cross-reactions and co-sensitizations are of great importance in understanding contact allergy and exposure sources. To investigate common cross-reactions and co-sensitizations in p-phenylenediamine (PPD)-sensitized and toluene-2,5-diamine (TDA)-sensitized individuals. From our patch test population, 8036 patients patch tested with the European baseline series were extracted. Readings had to be performed at least on day 3 according to ICDRG guidelines. Two hundred and fifty-one patients were sensitized to PPD and/or TDA; 231 patients were sensitized to PPD, and 109 to TDA. Significant differences were observed regarding the strengths of patch test reactions to PPD and number of cross-reactions. For TDA, a difference was found between all reaction strengths, except between + and ++ strengths. PPD-sensitized individuals were more likely to be sensitized to carba mix, cobalt chloride, colophonium, p-tert-butyl phenolformaldehyde resin, paraben mix, and methylisothiazolinone. TDA-sensitized individuals were more often sensitized to carba mix. Cross-reactivity was commonly found among individuals sensitized to PPD or TDA, and was strongly related to the strength of the patch test reaction. Regarding co-sensitizations, a frequently appearing or common exposure source could not be determined. However, modification of the allergen by, for example, the skin microbiota may have caused the formation of molecules that are, for the human immune system, indistinguishable from PPD. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Understanding and Developing Controversial Issues in College Courses.

ERIC Educational Resources Information Center

Payne, Brian K.; Gainey, Randy R.

2003-01-01

Discusses common controversial issues in different college disciplines, such as the death penalty and drug legalization. Also suggests useful methods for encouraging enlightening discussions, such as verbal and physical cues, student-centered activities, and text selection. (SLD)

Controversial Issues--Teachers' Attitudes and Practices in the Context of Citizenship Education

ERIC Educational Resources Information Center

Oulton, Christopher; Day, Vanessa; Dillon, Justin; Grace, Marcus

2004-01-01

Current conceptions of citizenship favour public involvement in dialogue on controversial issues such as GM food. 'Students with higher levels of civic knowledge are more likely to expect to participate in political and civic activities as adults' (Kerr et al., 2003, p. 4). Young people need to be aware of the nature of controversy and be able to…

The Vocational-Liberal Arts Controversy: Looking Backwards.

ERIC Educational Resources Information Center

Miles, Sue L.

The liberal arts-vocational education controversy is examined in this article through a series of fictitious letters based on historical facts that present the thoughts of key educational personalities regarding the community college's role in providing vocational education and liberal arts education. Part I, which takes the form of a letter and…

A Constructive Controversy Approach to "Case Studies"

ERIC Educational Resources Information Center

Bird, Sharon R.; Erickson, Karla A.

2010-01-01

On the basis of analysis of student responses to a case study titled "Drinks and Dinner," the authors evaluate the pedagogical potential of using constructive controversy case studies to teach about inequality. "Drinks and Dinner" is designed to capture the complexity of social interactions that defy simple solutions to engage students in…

Controversial medical and agri-food biotechnology: a cultivation analysis.

PubMed

Bauer, Martin W

2002-04-01

Whether biotechnology is one or several developments is not clear. Once distinctions are required, the question is: Which one prevails? When the good, the bad, and the ugly settle, where do they fall? Evaluation implies distinction, and representation drives attitude. The controversies over biotechnology are fertile ground on which to study these issues. The imports of genetically modified (GM) soya into Europe in 1996-97 and the cloning of Dolly the sheep from adult cells in 1997 changed the symbolic environment for genetic engineering. The ensuing public controversies came to focus mainly on field trials of GM crops and food labeling. This paper will explore the relationship between quality press coverage and public perception, in particular the cultivation of the contrast between "desirable" biomedical (RED) and "undesirable" agri-food (GREEN) biotechnology in Britain. The argument draws on a systematic analysis of the British press coverage of biotechnology from 1973 to 1999 and analysis of public perceptions in 1996 and 1999. The paper concludes that the debate over GM crops and food ingredients fostered the RED-GREEN contrast among the newspaper-reading public, thereby shielding RED biotechnology from public controversy, and ushered in a realignment of the regulatory framework in 2000.

Correlating the Ancient Maya and Modern European Calendars with High-Precision AMS 14C Dating

PubMed Central

Kennett, Douglas J.; Hajdas, Irka; Culleton, Brendan J.; Belmecheri, Soumaya; Martin, Simon; Neff, Hector; Awe, Jaime; Graham, Heather V.; Freeman, Katherine H.; Newsom, Lee; Lentz, David L.; Anselmetti, Flavio S.; Robinson, Mark; Marwan, Norbert; Southon, John; Hodell, David A.; Haug, Gerald H.

2013-01-01

The reasons for the development and collapse of Maya civilization remain controversial and historical events carved on stone monuments throughout this region provide a remarkable source of data about the rise and fall of these complex polities. Use of these records depends on correlating the Maya and European calendars so that they can be compared with climate and environmental datasets. Correlation constants can vary up to 1000 years and remain controversial. We report a series of high-resolution AMS 14C dates on a wooden lintel collected from the Classic Period city of Tikal bearing Maya calendar dates. The radiocarbon dates were calibrated using a Bayesian statistical model and indicate that the dates were carved on the lintel between AD 658-696. This strongly supports the Goodman-Martínez-Thompson (GMT) correlation and the hypothesis that climate change played an important role in the development and demise of this complex civilization. PMID:23579869

Controversy and Counternarrative in the Social Studies

ERIC Educational Resources Information Center

Shaver, Erik James

2017-01-01

This qualitative study sought to explore reasons why social studies teachers chose to teach controversial issues and counternarratives in their classroom in an era where doing so is dangerous for teachers and their job security, and how they go about doing so in their classrooms. The theoretical framework of this study encompassed the notion that…

Controversies in Alzheimer’s disease drug development

PubMed Central

Cummings, Jeffrey L.

2010-01-01

Understanding of the pathophysiological basis of Alzheimer’s disease (AD) is increasing rapidly and a variety of potential treatment modalities have emerged based on these improved mechanistic insights. The optimal way of proceeding with disease-modifying drug development remains to be clarified and controversies have emerged regarding the definition of Alzheimer’s disease, the participation of mild cognitive impairment patients in clinical trials, the definition of disease modification, the potential impediments to satisfaction from patients receiving disease-modifying therapy, the importance of add-on therapy with symptomatic agents, the optimal clinical trial design to demonstrate disease modification, the best means of minimizing time spent in Phase II of drug development, the potential role of adaptive designs in clinical trials, the use of enrichment designs in clinical trials, the role of biomarkers in clinical trials, the treatment of advanced patients with disease-modifying agents, and distinctions between disease modification and disease prevention. The questions surrounding these issues must be resolved as disease-modifying therapies for AD are advanced. These controversies are framed and potential directions towards resolution described. PMID:18925488

New perspectives for European climate services: HORIZON2020

NASA Astrophysics Data System (ADS)

Bruning, Claus; Tilche, Andrea

2014-05-01

The developing of new end-to-end climate services was one of the core priorities of 7th Framework for Research and Technological Development of the European Commission and will become one of the key strategic priorities of Societal Challenge 5 of HORIZON2020 (the new EU Framework Programme for Research and Innovation 2014-2020). Results should increase the competitiveness of European businesses, and the ability of regional and national authorities to make effective decisions in climate-sensitive sectors. In parallel, the production of new tailored climate information should strengthen the resilience of the European society to climate change. In this perspective the strategy to support and foster the underpinning science for climate services in HORIZON2020 will be presented.

Federal Judge Orders Showing of Controversial Film.

ERIC Educational Resources Information Center

Flygare, Thomas J.

1987-01-01

Reviews a recent court decision in Nebraska regarding the cancellation of a controversial film on the University of Nebraska campus. The film was cancelled after a state senator threatened to close the theater if the movie was shown. The lawsuit alleged the university violated the First Amendment in cancelling the film; the judge ruled for the…

Controversial Novels and Censorship in the Schools.

ERIC Educational Resources Information Center

Katz, John Stuart

The legal history of censorship in general in the United States as well as the legal context in particular of the censorship of novels from schools is discussed. This thesis deals with four novels which have aroused substantial controversy when taught in the schools. The novels are: "The Catcher in the Rye," by J. D. Salinger, "The Adventures of…

A Controversial Issue as an Educational Object

ERIC Educational Resources Information Center

Kouki, Elina; Virta, Arja

2016-01-01

The aim of this study is to examine upper secondary students' (n = 96) argumentation skills and ability to discuss a controversial issue: the evacuation of Finnish children to Sweden and other Nordic countries because of the war. According to their essays written on the basis of multifaceted and contradictory sources, most of the students were not…

Chemical sensitivity: pathophysiology or pathopsychology?

PubMed

Genuis, Stephen J

2013-05-01

Escalating numbers of people throughout the world are presenting to primary care physicians, allergists, and immunologists with myriad clinical symptoms after low-level exposure to assorted everyday chemicals such as smoke, perfumes, air fresheners, paints, glues, and other products. This clinical state is referred to by various diagnostic labels, including multiple chemical sensitivity disorder, environmental intolerance, chemical sensitivity (CS), and sensitivity-related illness, and has been the subject of much controversy within the health care community. The goal of this study was to provide a brief overview of the etiology, pathogenesis, clinical presentation, and management of CS. An evaluation of the medical community's response to this emerging diagnosis was also explored. This review was prepared by assessing available medical and scientific literature from MEDLINE, as well as by reviewing numerous books, toxicology journals, conference proceedings, government publications, and environmental health periodicals. A primary observation, however, is that there is limited scientific literature available on the issue of CS. The format of a traditional integrated review was chosen because such reviews play a pivotal role in scientific research and professional practice in medical issues with limited primary study and uncharted clinical territory. The sensitization state of CS seems to be initiated by a significant toxic exposure, occurring as a 1-time event, or on surpassing a threshold of toxicity after toxicant accrual from repeated lower-level exposures. Once sensitized through a toxicant-induced loss of tolerance, individuals exposed to inciting triggers such as minute amounts of diverse everyday chemicals may experience various clinical and immune sequelae, sometimes involving lymphocyte, antibody, or cytokine responses. Precautionary avoidance of inciting triggers will prevent symptoms, and desensitization immunotherapy or immune suppression may improve

Controversial Therapies for Young Children with Developmental Disabilities.

ERIC Educational Resources Information Center

Nickel, Robert E.

1996-01-01

This article examines reasons parents may choose a controversial alternative treatment for a child with developmental disabilities and reviews a few specific treatments--vitamin B-6 and magnesium, auditory integration training, megavitamins and minerals, Piracetam, intravenous immunoglobulin, and melatonin. Recommendations on talking with families…

The effects of controversy, concurrence seeking, and individualistic learning on achievement and attitude change

NASA Astrophysics Data System (ADS)

Johnson, Roger; Brooker, Charlotte; Stutzman, James; Hultman, Donald; Johnson, David W.

The effects of cooperative-controversy, cooperative-concurrence seeking, and individualistic learning were compared on motivation, achievement, and attitudes toward the science subject being studied. Eighty-four fifth-grade students were assigned to conditions on a stratified random basis controlling for sex and reading ability. In all three conditions students studied whether wolves should or should not be a protected species. The results indicate that cooperative-controversy resulted in the highest achievement, greatest motivation to learn more about wolves, more positive attitudes toward the wolf, and more positive attitudes toward controversy.

Teachers' Perceptions of the Role of Evidence in Teaching Controversial Socio-Scientific Issues

ERIC Educational Resources Information Center

Levinson, Ralph

2006-01-01

Eighty-three teachers across the curriculum were interviewed to explain their views on and approaches to, the teaching of socio-scientific controversial issues to 14-19 year olds, particularly with regard to developments in biomedicine and biotechnology. This study focused on teachers' views on the nature of evidence in controversial issues and…

Scientific Experts and the Controversy about Teaching Creation/Evolution in the UK Press

ERIC Educational Resources Information Center

Allgaier, Joachim

2010-01-01

The issue whether creationist accounts of the origins of life should be taught in science education alongside or even instead Darwin's theory of evolution is controversial in many countries. In 2002 there was a controversy around teaching creationism in science classes at a secondary school in England. The research presented in this paper uses…

The Seal Killing Controversy: What Are the Facts?

ERIC Educational Resources Information Center

Scheffer, Victor B.

1973-01-01

Discusses the seal controversy using the harp and Alaska fur seals to illustrate the two distinct issues, i.e., conservation (the effect of killing upon the animal population); and two, morality (the effect of killing upon the human spirit). Factual information combines with personal philosophy. (LK)

Disaster, Controversy--Are You Prepared for the Worst?

ERIC Educational Resources Information Center

Heller, Robert W.; And Others

1991-01-01

Provides demographic profiles from "Executive Educator's" fourth annual survey of U.S. school executives. Regarding disaster preparedness, only a small percentage of all districts in earthquake-prone areas have earthquake and fire action plans. Concerning controversial issues, teaching about substance abuse, child abuse, and teen suicide meets…

A Critique of "Controversial Medical Treatments of Learning Disabilities"

ERIC Educational Resources Information Center

Feingold, Benjamin F.

1977-01-01

The author replies to the article titled "Controversial Medical Treatments of Learning Disabilities" (R. Sieben), and discusses research on the relationship between food additives and hyperactivity, and dietary treatments for learning disabled children. (IM)

Sugar substitutes: Health controversy over perceived benefits

PubMed Central

Tandel, Kirtida R.

2011-01-01

Sugar is an inseparable part of the food we consume. But too much sugar is not ideal for our teeth and waistline. There have been some controversial suggestions that excessive sugar may play an important role in certain degenerative diseases. So artificial sweeteners or artificially sweetened products continue to attract consumers. A sugar substitute (artificial sweetener) is a food additive that duplicates the effect of sugar in taste, but usually has less food energy. Besides its benefits, animal studies have convincingly proven that artificial sweeteners cause weight gain, brain tumors, bladder cancer and many other health hazards. Some kind of health related side effects including carcinogenicity are also noted in humans. A large number of studies have been carried out on these substances with conclusions ranging from “safe under all conditions” to “unsafe at any dose”. Scientists are divided in their views on the issue of artificial sweetener safety. In scientific as well as in lay publications, supporting studies are often widely referenced while the opposing results are de-emphasized or dismissed. So this review aims to explore the health controversy over perceived benefits of sugar substitutes. PMID:22025850

Adjunctive use of the diode laser in non-surgical periodontal therapy: exploring the controversy.

PubMed

Porteous, Mary Sornborger; Rowe, Dorothy J

2014-04-01

Despite the controversy regarding clinical efficacy, dental hygienists use the diode laser as an adjunct to non-surgical periodontal therapy. The technique to maximize successful laser therapy outcome is controversial as well. The purpose of this review is to explore the scientific foundation of the controversy surrounding the use of the diode laser as an adjunct to non-surgical periodontal therapy. Further, this paper addresses the weaknesses in study design, the heterogeneity of methodology in the published clinical studies, especially the laser parameters, and how these issues impact the collective clinical and microbial data, and thus conclusions regarding clinical efficacy. Evaluation of the literature identifies possible mechanisms that could contribute to the varied, often conflicting results among laser studies that are the foundation of the controversy surrounding clinical efficacy. These mechanisms include current paradigms of periodontal biofilm behavior, tissue response to laser therapy being dependent on tissue type and health, and that the successful therapeutic treatment window is specific to the target tissue, biofilm composition, laser wavelength, and laser energy delivered. Lastly, this paper discusses laser parameters used in the various clinical studies, and how their diversity contributes to the controversy. Although this review does not establish clinical efficacy, it does reveal the scientific foundation of the controversy and the need for standardized, well designed randomized controlled clinical trials to develop specific guidelines for using the laser as an adjunct to non-surgical periodontal therapy. Using evidence-based laser guidelines would allow dental hygienists to provide more effective non-surgical periodontal care.

Early Childhood Commercial Exhibit Controversies: 1890 and 1990.

ERIC Educational Resources Information Center

Hewes, Dorothy W.

The controversy over the contrast between early childhood principles and the commercial exhibits at the 1990 annual meeting of the National Association for the Education of Young Children prompted a search for historical antecedents. Research disclosed that the first popular linking of Froebelian kindergarten curriculum and manufactured equipment…

The Ecology Controversy: Opposing Viewpoints. Critical Issues Series.

ERIC Educational Resources Information Center

McCuen, Gary E., Ed.; Bender, David L., Ed.

Ecological problems are explored in this book of sixteen student readings and exercises aimed at developing and applying critical thinking skills. The readings, mostly extracts from books and periodicals, are introduced by the editor and accompanied by questions. Chapter I, The Population Controversy, includes selections from Paul Ehrlich's The…

IQ Test Controversy: Past, Present, and Future Trends.

ERIC Educational Resources Information Center

Alford, David W.

The controversies surrounding the use of intelligence quotient (IQ) tests with children are summarized. This article discusses what intelligence is and how intelligence is measured. It also examines factors which can affect measurement, including examiner training or bias, examinee age, misinterpretation of test scores, and poor tests. The…

Perspective: Academic Controversies as a Vital Instructional Tool.

ERIC Educational Resources Information Center

Johnson, David W.; Johnson, Roger T.

1997-01-01

Advocates the use of academic controversies (student research and classroom debate on an issue with clearly defined positions). Identifies three ways that this educates students about civil justice: (1) students learn citizenship skills; (2) provides a procedure for resolving civil justice problems; and (3) increases academic learning. (MJP)

Teaching About the Creation/Evolution Controversy. Fastback 134.

ERIC Educational Resources Information Center

Bergman, Jerry

The booklet discusses questions related to teaching engendered by the creation/evolution controversy, presents current positions of educators and textbooks, and recommends a two-model teaching approach. It is divided into six chapters. Chapter I defines and summarizes evolution and creationism as different belief structures, and outlines various…

[Sensitive skin: a complex syndrome].

PubMed

Escalas-Taberner, J; González-Guerra, E; Guerra-Tapia, A

2011-10-01

Epidemiologic studies indicate that ever larger numbers of people report having sensitive skin, for which a European prevalence of 50% is estimated. Sensitive skin is characterized by hyperreactivity, with manifestations varying in relation to many factors. The pathogenesis of this disorder is poorly understood, although studies point to a biophysical mechanism. Objective diagnosis of sensitive skin is difficult, as information comes mainly from the patient's report of symptoms in the absence of effective, strongly predictive tests because of great interindividual variability in skin sensitivity. Substances that trigger a reaction in hypersensitive skin also vary greatly. The impact of this syndrome on quality of life is considerable and patients often present psychiatric symptoms; therefore, dermatologists should explore this possibility when taking a patient's history. Patient cooperation and physician persistence are both essential for treating sensitive skin. Copyright © 2011 Elsevier España, S.L. y AEDV. All rights reserved.

Controversy and consensus on a clinical pharmacist in primary care in the Netherlands.

PubMed

Hazen, Ankie C M; Wal, Aletta W van der; Sloeserwij, Vivianne M; Zwart, Dorien L M; Gier, Johan J de; Wit, Niek J de; Leendertse, Anne J; Bouvy, Marcel L; Bont, Antoinette A de

2016-10-01

Background Controversy about the introduction of a non-dispensing pharmacist in primary care practice hampers implementation. Objective The aim of this study is to systematically map the debate on this new role for pharmacists amongst all stakeholders to uncover and understand the controversy and consensus. Primary health care in the Netherlands. Method Q methodology. 163 participants rank-ordered statements on issues concerning the integration of a non-dispensing pharmacist in primary care practice. Stakeholder perspectives on the role of the non-dispensing pharmacist and pharmaceutical care in primary care. Results This study identified the consensus on various features of the non-dispensing pharmacist role as well as the financial, organisational and collaborative aspects of integrating a non-dispensing pharmacist in primary care practice. Q factor analysis revealed four perspectives: "the independent community pharmacist", "the independent clinical pharmacist", "the dependent clinical pharmacist" and "the medication therapy management specialist". These four perspectives show controversies to do with the level of professional independency of the non-dispensing pharmacist and the level of innovation of task performance. Conclusion Despite the fact that introducing new professional roles in healthcare can lead to controversy, the results of this Q study show the potential of a non-dispensing pharmacist as a pharmaceutical care provider and the willingness for interprofessional collaboration. The results from the POINT intervention study in the Netherlands will be an important next step in resolving current controversies.

Implementation Strategies for Gender-Sensitive Public Health Practice: A European Workshop.

PubMed

Oertelt-Prigione, Sabine; Dalibert, Lucie; Verdonk, Petra; Stutz, Elisabeth Zemp; Klinge, Ineke

2017-11-01

Providing a robust scientific background for the focus on gender-sensitive public health and a systematic approach to its implementation. Within the FP7-EUGenMed project ( http://eugenmed.eu ) a workshop on sex and gender in public health was convened on February 2-3, 2015. The experts participated in moderated discussion rounds to (1) assemble available knowledge and (2) identify structural influences on practice implementation. The findings were summarized and analyzed in iterative rounds to define overarching strategies and principles. The participants discussed the rationale for implementing gender-sensitive public health and identified priorities and key stakeholders to engage in the process. Communication strategies and specific promotion strategies with distinct stakeholders were defined. A comprehensive list of gender-sensitive practices was established using the recently published taxonomy of the Expert Recommendations for Implementing Change (ERIC) project as a blueprint. A clearly defined implementation strategy should be mandated for all new projects in the field of gender-sensitive public health. Our tool can support researchers and practitioners with the analysis of current and past research as well as with the planning of new projects.

Major Trends and Issues in Early Childhood Education: Challenges, Controversies, and Insights. (Second Edition).

ERIC Educational Resources Information Center

Isenberg, Joan Packer, Ed.; Jalongo, Mary Renck, Ed.

Noting that understanding the contexts, continuities, and controversies of early childhood education is especially challenging because of the diversity in the field, this book provides a critical examination of the issues and controversies surrounding early childhood practices, policies, and professional development. Following an introduction…

Teaching Controversial Topics to Skeptical High School Students

NASA Astrophysics Data System (ADS)

Ford, K. S.

2012-12-01

Tennessee passes the "Monkey Bill" (HB 0368, SB 0893), North Carolina's state government passes a law to criminalize reference in state documents to scientific models that predict sea level rise to reach at least one meter by the next century, and public concern still lags far behind the scientific community's concern on climate change. The American public and even science teachers across the country seem to have lost faith in the ability of the scientific community to unify a strong message about several important scientific lessons, including global warming in particular. This lack of a unified message has weakened the ability of science teachers to effectively teach the lesson of global warming. For science teachers in strongly conservative areas of the country, it is much easier to omit difficult topics and avoid angering parents and school board members. Teachers who do feel strongly about scientifically proven, yet publically controversial topics CAN teach these topics in conservative areas by confirming students' belief systems by being honest and open about motivations surrounding both sides of controversial topics, and by using vocabulary that avoids triggering negative perceptions about these controversial topics. For true learning and change of preconceived opinion to take place, it is important for students to come to the understanding in their own minds in an open and safe learning environment instead of having the message "preached" to them, which only serves to make them feel unintelligent and defensive if they disagree. This presentation will include lessons learned from a practicing science teacher who works in a community that overwhelmingly disputes the validity of human impacts on climate change.

Controversies in water management: Frames and mental models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolkman, M.J.; Department of Civil Engineering and Management, Faculty of Engineering Technology; Veen, A. van der

Controversies in decision and policy-making processes can be analysed using frame reflection and mental model mapping techniques. The purpose of the method presented in this paper is to improve the quality of the information and interpretations available to decision makers, by surfacing and juxtaposing the different frames of decision makers, experts, and special interests groups. The research provides a new method to analyse frames. It defines a frame to consist of perspectives and a mental model, which are in close interaction (through second order learning processes). The mental model acts like a 'filter' through which the problem situation is observed.more » Five major perspective types guide the construction of meaning out of the information delivered by the mental model, and determine what actors see as their interests. The perspective types are related to an actor's institutional and personal position in the decision making process. The method was applied to a case, in order to test its viability. The case concerns the decision making process and environmental impact assessment procedure for the improvement of dike ring 53 in the Netherlands, which was initiated by the Dutch 'Flood Defences Act 1996'. In this specific case the perspectives and mental models of stakeholders were elicited to explain controversies. The case was analysed with regard to the conflicts emerging between stakeholders, on an individual level. The influence of institutional embedding of individuals on the use of information and the construction of meaning, and the limits of a participatory approach were analysed within the details of controversies that emerged during the case analysis. Complicating factor appeared to be the interaction between national dike safety norms (short term) and local water management problems (long term). Revealed controversies mainly concerned disputes between an organisational and a technical perspective. But also disputes on distribution of

The Effects of Controversy, Concurrence Seeking, and Individualistic Learning on Achievement and Attitude Change.

ERIC Educational Resources Information Center

Johnson, Roger; And Others

1985-01-01

Compared effects of cooperative learning activities (with and without structured controversy) and individualistic learning activities on the achievement and attitudes of fifth graders (N=84) toward wolves. Results show that cooperative-controversy resulted in the highest achievement, greatest motivation to learn about wolves, and more positive…

Liebig-Wohler Controversy and the Concept of Isomerism

ERIC Educational Resources Information Center

Esteban, Soledad

2008-01-01

Very often controversies contribute to the development of science. An example is the conflict between Liebig and Wohler on the occasion of their analyses of fulminates and cyanates, which showed that compounds with different properties could have the same composition. Their results, together with other similar evidences, led Berzelius to recognize…

Relational Frame Theory: An Overview of the Controversy

ERIC Educational Resources Information Center

Gross, Amy C.; Fox, Eric J.

2009-01-01

Although Skinner's "Verbal Behavior" (1957) was published over 50 years ago, behavior-analytic research on human language and cognition has been slow to develop. In recent years, a new behavioral approach to language known as relational frame theory (RFT) has generated considerable attention, research, and debate. The controversy surrounding RFT…

Beyond Textbook Civics/Teaching the Confederate Monument Controversy

ERIC Educational Resources Information Center

Allen, Stephanie Teachout

2017-01-01

Civics education shouldn't be confined to dusty textbooks, as evidenced by this assortment of projects. In one unit, elementary students play out the presidential election--from campaigning to inauguration day--using the Storypath approach. In another project, 5th graders explore the controversy about Confederate monuments by studying a local…

Teaching Controversial Materials: Teaching about the Nuclear Issue.

ERIC Educational Resources Information Center

Wall, Joseph

1986-01-01

Describes difficulties encountered in presenting a college course on nuclear weapons and disarmament. Maintains that such courses must strive for a fuller historical account of the arms race, in addition to stressing the humanistic and ethical questions involved. Warns that controversy will arise and concludes that even blind anger is preferable…

Hot Buttons. Unraveling 10 Controversial Issues in Education.

ERIC Educational Resources Information Center

Walling, Donovan R., Ed.

This book is a collection of essays that deal with 10 current controversial issues. The issues are also the topics of 10 recent fastbacks from the Phi Delta Kappa fastback series published between 1993 and 1996. Following the introduction, the articles include the following: (1) "Accountability" (Jack Frymier); (2) "Assessment…

Efficiency measures and output specification : the case of European railways

DOT National Transportation Integrated Search

2000-12-01

This study analyzes the sensitivity of the efficiency indicators of a sample of European railway companies to different alternatives in output specification. The results vary according to the specification selected. Investigating the causes of these ...

Polemics in Public: Poncelet, Gergonne, Plücker, and the Duality Controversy.

PubMed

Lorenat, Jemma

2015-12-01

A plagiarism charge in 1827 sparked a public controversy centered between Jean-Victor Poncelet (1788-1867) and Joseph-Diez Gergonne (1771-1859) over the origin and applications of the principle of duality in geometry. Over the next three years and through the pages of various journals, monographs, letters, reviews, reports, and footnotes, vitriol between the antagonists increased as their potential publicity grew. While the historical literature offers valuable resources toward understanding the development, content, and applications of geometric duality, the hostile nature of the exchange seems to have deterred an in-depth textual study of the explicitly polemical writings. We argue that the necessary collective endeavor of beginning and ending this controversy constitutes a case study in the circulation of geometry. In particular, we consider how the duality controversy functioned as a medium of communicating new fundamental principles to a wider audience of practitioners.

What Is a Controversial Issue? Implications for the Treatment of Religious Beliefs in Education

ERIC Educational Resources Information Center

Cooling, Trevor

2012-01-01

An important debate in the literature on controversial issues concerns how to identify them. This matters for teachers because settled issues should be taught directively and controversial issues should be taught nondirectively. Teachers are professionally accountable for this decision. This article examines the contribution of Michael Hand to the…

Diversity in Information Technology Education: Issues and Controversies

ERIC Educational Resources Information Center

Trajkovski, Goran, Ed.

2006-01-01

"Diversity in Information Technology Education: Issues and Controversies" sheds light on the status of diversity in the field of IT education. It identifies a wide range of problems that educators face on a daily basis, and gives practical, applicable solutions, mainly by showcasing successful and replicable examples. The chapters in "Diversity in…

European Education, European Citizenship? On the Role of Education in Constructing Europeanness.

ERIC Educational Resources Information Center

Ollikainen, Aaro

2000-01-01

Focuses on the role of the European Union (EU) education programs in fostering a sense of European citizenship. Addresses the five meanings given to the concept of European citizenship: (1) recognition of European heritage; (2) EU loyalty; (3) right of free movement; (4) political participation; and (5) active citizenship. (CMK)

Breast vs. bottle: a new controversy.

PubMed

Caruncho, E S

1979-01-01

The infant feeding controversy had its roots in the early 1960s, when the declining birth rate in industrialized countries led the multinational baby food manufacturers to look to the fast growing populations of the 3rd World to bolster their sales. The connection between infant formula, malnutrition, and infant mortality has been increasingly recognized by the World Health Organization and other groups and individuals. The expense of infant formula, overdilution by impoverished parents attempting to stretch the food budget, and poor sanitary conditions made millions of 3rd World babies victims of malnutrition, infectious diseases, and premature death. In 1974, the British public interest group called War on Want launched an international campaign against the aggressive promotional practices of the infant formula manufacturers. A nonbinding agreement between the International Council of Infant Food Industries and their critics in Geneva in 1979 was regarded as a truce rather than a solution to the controversy, but worldwide attention was attracted to the infant feeding issue. Scientific research has confirmed the advantages of breast feeding in providing immunity as well as optimal nutrition and contraceptive protection. Although greater convenience, necessity of working outside the home, or insufficient milk lead some mothers to bottle feed, misleading and aggressive promotional campaigns of the infant feeding companies have been very effective in persuading mothers of all income levels to choose bottle feeding. With increasing realization of the benefits of breast feeding, efforts are now underway to reverse the trends.

The missing link of Jewish European ancestry: contrasting the Rhineland and the Khazarian hypotheses.

PubMed

Elhaik, Eran

2013-01-01

The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The "Rhineland hypothesis" depicts Eastern European Jews as a "population isolate" that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the "Khazarian hypothesis" suggests that Eastern European Jews descended from the Khazars, an amalgam of Turkic clans that settled the Caucasus in the early centuries CE and converted to Judaism in the 8th century. Mesopotamian and Greco-Roman Jews continuously reinforced the Judaized empire until the 13th century. Following the collapse of their empire, the Judeo-Khazars fled to Eastern Europe. The rise of European Jewry is therefore explained by the contribution of the Judeo-Khazars. Thus far, however, the Khazars' contribution has been estimated only empirically, as the absence of genome-wide data from Caucasus populations precluded testing the Khazarian hypothesis. Recent sequencing of modern Caucasus populations prompted us to revisit the Khazarian hypothesis and compare it with the Rhineland hypothesis. We applied a wide range of population genetic analyses to compare these two hypotheses. Our findings support the Khazarian hypothesis and portray the European Jewish genome as a mosaic of Near Eastern-Caucasus, European, and Semitic ancestries, thereby consolidating previous contradictory reports of Jewish ancestry. We further describe a major difference among Caucasus populations explained by the early presence of Judeans in the Southern and Central Caucasus. Our results have important implications for the demographic forces that shaped the genetic diversity in the Caucasus and for medical studies.

Progressive Transitions in Chemistry Teachers' Understanding of Nature of Science Based on Historical Controversies

ERIC Educational Resources Information Center

Niaz, Mansoor

2009-01-01

The objective of this study is to facilitate progressive transitions in chemistry teachers understanding of nature of science in the context of historical controversies. Selected controversies referred to episodes that form part of the chemistry curriculum both at secondary and university freshman level. The study is based on 17 in-service…

Darwinian Controversies: An Historiographical Recounting

NASA Astrophysics Data System (ADS)

Depew, David J.

2010-05-01

This essay reviews key controversies in the history of the Darwinian research tradition: the Wilberforce-Huxley debate in 1860, early twentieth-century debates about the heritability of acquired characteristics and the consistency of Mendelian genetics with natural selection; the 1925 Scopes trial about teaching evolution; tensions about race, culture, and eugenics at the 1959 centenary celebration Darwin’s Origin of Species; adaptationism and its critics in the Sociobiology debate of 1970s and, more recently, Evolutionary Psychology; and current disputes about Intelligent Design. These controversies, I argue, are etched into public memory because they occur at the emotionally charged boundaries between public-political, technical-scientific, and personal-religious spheres of discourse. Over most of them falls the shadow of eugenics. The main lesson is that the history of Darwinism cannot be told except by showing the mutual influence of the different norms of discourse that obtain in the personal, technical, and public spheres. Nor can evolutionary biology successfully be taught to citizens and citizens-to-be until the fractious intersections between spheres of discourse have been made explicit. In the course of showing why, I take rival evolutionary approaches to be dynamical historical research traditions rather than static theories. Accordingly, I distinguish Darwin’s version of Darwinism from its later transformations. I pay special attention to the role Darwin assigned to development in evolution, which was marginalized by twentieth-century population genetical Darwinism, but has recently resurfaced in new forms. I also show how the disputed phrases “survival of the fittest” and “social Darwinism” have shaped personal anxieties about “Darwinism,” have provoked public opposition to teaching evolution in public schools, and have cast a shadow over efforts to effectively communicate to the public largely successful technical efforts to make

Adolescent Controversial Status Brokers: A Double-Edged Sword

ERIC Educational Resources Information Center

Borowski, Sarah; Zeman, Janice; Carboni, Inga; Gilman, Rich; Thrash, Todd

2017-01-01

Using a 3-wave longitudinal, multidimensional approach, this study investigated the influence of social network position and social status on the psychosocial outcomes of 440 youth (45.1% girls; M[subscript age] = 16.1 years; 90.9% Caucasian) over 26 months, focusing on the controversial status classification (i.e., youth who are highly liked and…

Teaching Darwin: Contemporary Social Studies through Controversial Issues

ERIC Educational Resources Information Center

Swanson, Helge

2010-01-01

I explore Darwin and his Theory of Natural Selection from a Social Science perspective and a social studies approach of inquiry into contemporary issues. This approach augments the more common natural science focus on the mechanics of natural selection and evolution in favor of a focus on social issues, controversy, and dialog necessary to support…

Taking One's Principles Seriously: A Teacher Confronts Controversy

ERIC Educational Resources Information Center

Hare, William

2010-01-01

A teacher faces hostility from certain colleagues who view his decision to attend a controversial lecture as tantamount to the repudiation of the principle of inclusive education and the rights of students with disabilities. The teacher sees the proposed boycott of the lecture as a form of censorship threatening freedom of inquiry and critical…

Tracking: Conflicts and Resolutions. Controversial Issues in Education.

ERIC Educational Resources Information Center

Lockwood, Anne Turnbaugh

The educational tracking system raises highly controversial issues. This book offers both the viewpoints of researchers who have grappled with the issue of tracking and the personal experiences of school staff who have wrestled with the issue of whether or not to track instruction. It presents summaries of interviews that were conducted with three…

The Problem of Catholic School Teachers Deferring to the Home on Controversial Religious Issues

ERIC Educational Resources Information Center

McDonough, Graham P.

2010-01-01

This paper observes that an ironic tension occurs in the discussion of controversial issues in some Catholic schools. One technique that teachers use in response to student disagreement with the official Church view on a controversial issue like contraception, homosexuality, or female ordination is to present Church teaching but then suggest that…

Vascular Access Guidelines: Summary, Rationale, and Controversies.

PubMed

Sequeira, Adrian; Naljayan, Mihran; Vachharajani, Tushar J

2017-03-01

Dialysis vascular access management in the United States changed significantly after National Kidney Foundation-Kidney Disease Outcome Quality Initiative (NKF-KDOQI) clinical practice guidelines were first published in 1997. The Centers for Medicare and Medicaid Service adopted these guidelines and in collaboration with the End-Stage Renal Disease Networks established the Fistula First Breakthrough Initiative (FFBI) in 2003 to improve the rate of arteriovenous fistula use over arteriovenous graft and central venous catheter in the dialysis population. The implementation of guidelines and FFBI has led to a significant increase in the arteriovenous fistula use in the prevalent dialysis population. The guidelines are criticized for being opinion based and often impractical. Over the past 2 decades, the patient population undergoing dialysis has become older with complex comorbidities and challenges for creating an ideal vascular access. Advancing knowledge about access pathophysiology, improved treatment options, and improved process of care with team approach model point toward diminishing relevance of few of the existing guidelines. Moreover, several guidelines remain controversial and may be leading to clinical decisions that may be unfavorable to the patients. The review discusses the historical aspect of vascular access care in the United States and evolution of current practice standards and controversies surrounding few of these guidelines in the current time. Published by Elsevier Inc.

Military laser weapons: current controversies.

PubMed

Seet, B; Wong, T Y

2001-09-01

Military laser weapons systems are becoming indispensable in most modern armies. These lasers have undergone many stages of development, and have outpaced research on eye protection measures, which continue to have inherent limitations. Eye injuries caused by military lasers are increasingly reported, leading to speculation that these would become an important cause of blinding in modern conflicts. As part of the effort to ban inhumane weapons, international laws have been passed to restrict the proliferation of such blinding weapons. However, there are controversies concerning the interpretation, implementation and effectiveness of these laws. The ophthalmic community can play a greater role in highlighting ocular morbidity from military lasers, and in preventing their further proliferation.

Current controversies in Niemann-Pick C1 disease: steroids or gangliosides; neurons or neurons and glia.

PubMed

Erickson, Robert P

2013-05-01

There has been a recent explosion in research on Niemann-Pick type C disease. Much of the work has used mouse models or cells in culture to elucidate the pathophysiological mechanisms resulting in the phenotype of the disease. This work has generated several contrasting views on the mechanism, which are labeled 'controversies' here. In this review, two of these controversies are explored. The first concerns which stored materials are causative in the disease: cholesterol, gangliosides and sphingolipids, or something else? The second concerns which cells in the body require Npc1 in order to function properly: somatic cells, neurons only, or neurons and glia? For the first controversy, a clear answer has emerged. More research will be needed in order to definitively solve the second controversy.

DTCA of prescription medicines in the European Union: is there still a need for a ban?

PubMed

Poser, Mareen

2010-12-01

The pharmaceutical sector is one of the main markets in the European Union. The consumption of medicines is high and steadily increasing. However, the pharmaceutical market is subject to a wider range of restrictions than almost any other sector. The restrictions mainly apply to information provision and advertising practice within the community. One of the main features in pharmaceutical regulation is the ban on direct-to-consumer advertising (DTCA) of prescription medicines. However, an abolition of the ban is controversial in the European Community, especially as the pharmaceutical industry keeps pleading for its ability to use the highly effective marketing strategy of DTCA to promote prescription medicines to the general public. Such advertising is only allowed in two jurisdictions in the world, New Zealand and the United States. In both systems the impact of DTCA on the consumer and the economy has been subject to research. The outcome of these studies is outlined in this article. Since the European Commission has provided a new proposal to amend the current information practice regarding prescription medicines in 2008 (European Commission, Proposal for a Directive of the European Parliament and of the Council Amending, as Regards Information to the General Public on Medicinal Products Subject to Medical Prescription, Directive 2001/83/EC on the Community Code Relating to Medicinal Products for Human Use, COM/2008/0663 final) it is time to examine different options to regulate the provision of information and discuss the need for a ban of DTCA.

Perspectives in patent law: overview, careers, and controversies.

PubMed

Davis, Clara

2009-01-01

This paper is directed to scientists and engineers who wish to learn more about careers in patent law. It presents an overview of the patent process along with a description of the various roles of individuals and institutions involved. Finally, the paper briefly discusses a few of the more controversial issues in the patent law field today.

Centimeter repeatability of the VLBI estimates of European baselines

NASA Technical Reports Server (NTRS)

Rius, Antonio; Zarraoa, Nestor; Sardon, Esther; Ma, Chopo

1992-01-01

In the last three years, the European Geodetic Very Long Baseline Interferometry (VLBI) Network has grown to a total of six fixed antennas placed in Germany, Italy, Spain and Sweden, all equipped with the standard geodetic VLBI instrumentation and data recording systems. During this period of time, several experiments have been carried out using this interferometer providing data of very high quality due to the excellent sensitivity and performance of the European stations. The purpose of this paper is to study the consistency of the VLBI geodetic results on the European baselines with respect to the different degrees of freedom in the analysis procedure. Used to complete this study were both real and simulated data sets, two different software packages (OCCAM 3.0 and CALC 7.4/SOLVE), and a variety of data analysis strategies.

[Foucault, Derrida, and the history of madness: notes on a controversy].

PubMed

Pereira Neto, A F

1998-01-01

The publication of the book Folie et Déraison. Histoire de la Folie à l'Age Classique (1961), by Michel Foucault, sparked a debate between the author and philosopher Jacques Derrida during the 1960s and 70s. Derrida criticized the methodological proposal and organization of the History of Madness presented by Foucault in the foreword to the first edition. The controversy appears to have motivated the author to withdraw this same foreword from the second edition. The purpose of this article is to analyze some current points in this controversy. It also presents a research agenda for an understanding of the reasons leading Foucault to take this stance.

Imaging Management of Breast Density, a Controversial Risk Factor for Breast Cancer.

PubMed

Falcon, Shannon; Williams, Angela; Weinfurtner, Jared; Drukteinis, Jennifer S

2017-04-01

Breast density is well recognized as an independent risk factor for the development of breast cancer. However, the magnitude of risk is controversial. As the public becomes increasingly aware of breast density as a risk factor, legislation and notification laws in relation to breast density have become common throughout the United States. Awareness of breast density as a risk factor for breast cancer presents new challenges for the clinician in the approach to the management and screening of women with dense breasts. The evidence and controversy surrounding breast density as a risk factor for the development of breast cancer are discussed. Common supplemental screening modalities for breast cancer are also discussed, including tomosynthesis, ultrasonography, and magnetic resonance imaging. A management strategy for screening women with dense breasts is also presented. The American College of Radiology recognizes breast density as a controversial risk factor for breast cancer, whereas the American Congress of Obstetricians and Gynecologists recognizes breast density as a modest risk factor. Neither organization recommends the routine use of supplemental screening in women with dense breasts without considering additional patient-related risk factors. Breast density is a poorly understood and controversial risk factor for the development of breast cancer. Mammography is a screening modality proven to reduce breast cancer-related mortality rates and is the single most appropriate tool for population-based screening. Use of supplemental screening modalities should be tailored to individual risk assessment.

European consensus statement on the prevention of venous thromboembolism. European Consensus Conference, Windsor, U.K., November, 1991.

PubMed

Haas, S

1993-12-01

Since the Consensus Conference of the National Institute of Health in 1986, the developments in the field of prevention of venous thromboembolism were mainly characterized by a more specific and extended use of new prophylactic agents such as low molecular weight heparins as well as the perception that outpatients may be at risk for thromboembolic complications, too. Therefore, in November 1991, a European Consensus Conference on the prevention of thromboembolism was held in Windsor, UK, in order to analyse the risk constellation of various patient populations and to give recommendations for primary prophylaxis in general surgery, urology, neurosurgery, orthopaedic and trauma surgery, obstetrics and gynaecology and medical patients. In addition, the cost-effectiveness of the various methods was highlighted, and the question of secondary prevention addressed. The meeting was organized under the patronage of the European Economic Commission, and experts from 15 different countries were invited to participate. The conference was organized according to acknowledged guidelines of consensus conference organization, i.e. each expert had to formulate his provisional standpoint, the working documents were compiled by the organizer, and this file was sent to the delegates before the conference. During the first part of the meeting, the delegates presented their views in plenary sessions. Controversial points were discussed in working groups, and the results were discussed in plenary sessions. Consensus or lack of accord was documented and the open questions were formulated in order to be answered by future studies. The published statements and recommendations are based on different levels of evidence.(ABSTRACT TRUNCATED AT 250 WORDS)

[The controversy of routine articulator mounting in orthodontics].

PubMed

Wang, Li; Han, Xianglong; Bai, Ding

2013-06-01

Articulators have been widely used by clinicians of dentistry. But routine articulator mounting is still controversial in orthodontics. Orthodontists oriented by gnathology approve routine articulator mounting while nongnathologic orthodontists disapprove it. This article reviews the thoughts of orthodontist that they agree or disagree with routine articulator mounting based on the considerations of biting, temporomandibular disorder (TMD), periodontitis, and so on.

Hate Speech: The History of an American Controversy.

ERIC Educational Resources Information Center

Walker, Samuel

Noting that no other country in the world offers protection to offensive speech, this book provides a comprehensive account of the history of the hate speech controversy in the United States. The book examines the issue, from the conflicts over the Ku Klux Klan in the 1920s and American Nazi groups in the 1930s, to the famous Skokie, Illinois…

Dissociative identity disorder: a controversial diagnosis.

PubMed

Gillig, Paulette Marie

2009-03-01

A brief description of the controversies surrounding the diagnosis of dissociative identity disorder is presented, followed by a discussion of the proposed similarities and differences between dissociative identity disorder and borderline personality disorder. The phenomenon of autohypnosis in the context of early childhood sexual trauma and disordered attachment is discussed, as is the meaning of alters or alternate personalities. The author describes recent neurosciences research that may relate the symptoms of dissociative identity disorder to demonstrable disordered attention and memory processes. A clinical description of a typical patient presentation is included, plus some recommendations for approaches to treatment.

Controversies in Oral and Maxillofacial Pathology.

PubMed

Peacock, Zachary S

2017-11-01

Several benign pathologic entities that are commonly encountered by the oral and maxillofacial surgeon remain controversial. From etiology to treatment, no consensus exists in the literature regarding the best treatment of benign lesions, such as the keratocystic odontogenic tumor, giant cell lesion, or ameloblastoma. Given the need for often-morbid treatment to prevent recurrence of these lesions, multiple less-invasive treatments exist in the literature for each entity with little agreement. As the molecular and genomic pathogenesis of these lesions are better understood, directed treatments will hopefully lessen the contention in management. Copyright © 2017 Elsevier Inc. All rights reserved.

Intellectual property and information controversy (II)

NASA Astrophysics Data System (ADS)

Aoyama, Hirokazu

As advanced information has been proceeded rapidly, intellectual property has become more important than ever as business resources of enterprises. Based on the former report by the author "present status of and trend in intellectual property" this paper describes "information" related intellectual property controversy which have been occurred, that is, 1) affairs related to computer hardwares and softwares (the case of compatible machines and OS, the case of application softwares, computer crimes) and 2) affairs on trade secret (the case of revealing enterprises'secret, the case of industrial espionage). It also discusses how intellectual property should be protected and utilized from now on.

Teaching Controversy by Seminar: An Example in Quaternary Geomorphology.

ERIC Educational Resources Information Center

Harwood, Doug

1987-01-01

Describes how seminar work can be structured to help students develop skills of critical thinking and expression when discussing controversial issues in their chosen subject. Particular emphasis is given to methods of organizing instructional materials and appropriate roles for seminar leaders. The debate surrounding the existence of a prehistoric…

What Determines Student Acceptance of Politically Controversial Scientific Conclusions?

ERIC Educational Resources Information Center

Walker, J. D.; Wassenberg, Deena; Franta, Gabriel; Cotner, Sehoya

2017-01-01

Certain scientific conclusions are controversial, in that they are rejected by a substantial proportion of nonscientists despite an overwhelming scientific consensus. Science educators are motivated to help students understand the evidence behind the scientific consensus on these matters and to move students' views into alignment with those held…

Childhood Psychological Disorders: Current Controversies. Making Sense of Psychology

ERIC Educational Resources Information Center

Bursztyn, Alberto M., Ed.

2011-01-01

This accessible, informative book will help teachers, parents, and practitioners make sense of current issues and controversies surrounding childhood disabilities. Almost 12 percent of children in American schools have been identified as disabled in ways that interfere with their capacity to learn. Yet parents of children with disabilities often…

Spine Trauma-What Are the Current Controversies?

PubMed

Oner, Cumhur; Rajasekaran, Shanmuganathan; Chapman, Jens R; Fehlings, Michael G; Vaccaro, Alexander R; Schroeder, Gregory D; Sadiqi, Said; Harrop, James

2017-09-01

Although less common than other musculoskeletal injuries, spinal trauma may lead to significantly more disability and costs. During the last 2 decades there was substantial improvement in our understanding of the basic patterns of spinal fractures leading to more reliable classification and injury severity assessment systems but also rapid developments in surgical techniques. Despite these advancements, there remain unresolved issues concerning the management of these injuries. At this moment there is persistent controversy within the spinal trauma community, which can be grouped under 6 headings. First of all there is still no unanimity on the role and timing of medical and surgical interventions for patients with associated neurologic injury. The same is also true for type and timing of surgical intervention in multiply injured patients. In some common injury types like odontoid fractures and burst type (A3-A4) fractures in thoracolumbar spine, there is wide variation in practice between operative versus nonoperative management without clear reasons. Also, the role of different surgical approaches and techniques in certain injury types are not clarified yet. Methods of nonoperative management and care of elderly patients with concurrent complex disorders are also areas where there is no consensus. In this overview article the main reasons for these controversies are reviewed and the possible ways for resolutions are discussed.

The Missing Link of Jewish European Ancestry: Contrasting the Rhineland and the Khazarian Hypotheses

PubMed Central

Elhaik, Eran

2013-01-01

The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The “Rhineland hypothesis” depicts Eastern European Jews as a “population isolate” that emerged from a small group of German Jews who migrated eastward and expanded rapidly. Alternatively, the “Khazarian hypothesis” suggests that Eastern European Jews descended from the Khazars, an amalgam of Turkic clans that settled the Caucasus in the early centuries CE and converted to Judaism in the 8th century. Mesopotamian and Greco–Roman Jews continuously reinforced the Judaized empire until the 13th century. Following the collapse of their empire, the Judeo–Khazars fled to Eastern Europe. The rise of European Jewry is therefore explained by the contribution of the Judeo–Khazars. Thus far, however, the Khazars’ contribution has been estimated only empirically, as the absence of genome-wide data from Caucasus populations precluded testing the Khazarian hypothesis. Recent sequencing of modern Caucasus populations prompted us to revisit the Khazarian hypothesis and compare it with the Rhineland hypothesis. We applied a wide range of population genetic analyses to compare these two hypotheses. Our findings support the Khazarian hypothesis and portray the European Jewish genome as a mosaic of Near Eastern-Caucasus, European, and Semitic ancestries, thereby consolidating previous contradictory reports of Jewish ancestry. We further describe a major difference among Caucasus populations explained by the early presence of Judeans in the Southern and Central Caucasus. Our results have important implications for the demographic forces that shaped the genetic diversity in the Caucasus and for medical studies. PMID:23241444

The Role of Historical-Philosophical Controversies in Teaching Sciences: The Debate between Biot and Ampere

ERIC Educational Resources Information Center

Braga, Marco; Guerra, Andreia; Reis, Jose Claudio

2012-01-01

This paper evaluates the viability of using controversies in teaching. An educational project has been elaborated in which some historical-philosophical clashes were introduced into the classical syllabus of physics. The historical-philosophical controversy dealt with here, took place between the French physicists Biot and Ampere in the 19th…

Research in the Wake of the No Child Left Behind Act: Why the Controversies Will Continue and Some Suggestions for Controversial Research

ERIC Educational Resources Information Center

Brigham, Frederick J.; Gustashaw, William E., III; Wiley, Andrew L.; Brigham, Michele St. Peter

2004-01-01

The authors provide an analysis of why the controversies surrounding educational treatment are likely to continue even with scientific validation of practices as called for in the No Child Left Behind (NCLB) act. They describe how bias in human judgment makes it difficult to trust others and also difficult to doubt oneself relative to important…

Clarifying Public Controversy: An Approach to Teaching Social Studies.

ERIC Educational Resources Information Center

Newmann, Fred M.; Oliver, Donald W.

This book presents a rational discussion process approach to the teaching of specific social controversies in the social studies in secondary schools. The authors provide an in-depth analysis of this approach which includes both theory and application. The introductory chapters place the discussion process framework within terms of American values…

Teacher College Students' Views of Controversial Environmental Issues: Ambivalence and Readiness to Adopt a Stance

ERIC Educational Resources Information Center

Weinberger, Yehudith; Dreyfus, Amos

2013-01-01

One of the most important goals of discussing controversial issues in the classroom is to educate students to possess an inclination towards reason, open mindedness and fairness. However, research tends to show that teachers are not adequately trained to lead fruitful discussions about controversial issues and do not possess the necessary skills…

The European Cooperation Is Facing New Challenges--Some Impact on Citizenship Education in the Netherlands

ERIC Educational Resources Information Center

Oonk, Henk

2014-01-01

The crisis in Europe constitutes a major test for the very pursuit of European integration and for its legitimacy in the eyes of the citizens. In this paper a number of striking economic aspects of the crisis will be discussed next to political tensions concerning sensitive issues. Given the decline in the support for the European integration…

European Surveillance System on Contact Allergies (ESSCA): results with the European baseline series, 2013/14.

PubMed

Uter, W; Amario-Hita, J C; Balato, A; Ballmer-Weber, B; Bauer, A; Belloni Fortina, A; Bircher, A; Chowdhury, M M U; Cooper, S M; Czarnecka-Operacz, M; Dugonik, A; Gallo, R; Giménez-Arnau, A; Johansen, J D; John, S M; Kieć-Świerczyńska, M; Kmecl, T; Kręcisz, B; Larese Filon, F; Mahler, V; Pesonen, M; Rustemeyer, T; Sadowska-Przytocka, A; Sánchez-Pérez, J; Schliemann, S; Schuttelaar, M L; Simon, D; Spiewak, R; Valiukevičienė, S; Weisshaar, E; White, I R; Wilkinson, S M

2017-09-01

Contact allergy is a common condition and can severely interfere with daily life or professional activities. Due to changes in exposures, such as introduction of new substances, new products or formulations and regulatory intervention, the spectrum of contact sensitization changes. To evaluate the current spectrum of contact allergy to allergens present in the European baseline series (EBS) across Europe. Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (ESSCA, www.essca-dc.org) in consecutively patch-tested patients, 2013/14, in 46 departments in 12 European countries. Altogether, 31 689 patients were included in the analysis. Compared to a similar analysis in 2004, the prevalence of contact allergy to methylisothiazolinone went up to around 20% in several departments. In comparison, contact allergy to the metals nickel, cobalt and chromium remained largely stable, at 18.1%, 5.9% and 3.2%, respectively, similar to mostly unchanged prevalence with fragrance mix I, II and Myroxylon pereirae (balsam of Peru) at 7.3%, 3.8% and 5.3%, respectively. In the subgroup of departments diagnosing (mainly) patients with occupational contact dermatitis, the prevalence of work-related contact allergies such as epoxy resin or rubber additives was found to be increased, compared to general dermatology departments. Continuous surveillance of contact allergy based on network data offers the identification of time trends or persisting problems, and thus enables focussing in-depth research (subgroup analyses, exposure analysis) on areas where it is needed. © 2017 European Academy of Dermatology and Venereology.

A substantial prehistoric European ancestry amongst Ashkenazi maternal lineages.

PubMed

Costa, Marta D; Pereira, Joana B; Pala, Maria; Fernandes, Verónica; Olivieri, Anna; Achilli, Alessandro; Perego, Ugo A; Rychkov, Sergei; Naumova, Oksana; Hatina, Jiři; Woodward, Scott R; Eng, Ken Khong; Macaulay, Vincent; Carr, Martin; Soares, Pedro; Pereira, Luísa; Richards, Martin B

2013-01-01

The origins of Ashkenazi Jews remain highly controversial. Like Judaism, mitochondrial DNA is passed along the maternal line. Its variation in the Ashkenazim is highly distinctive, with four major and numerous minor founders. However, due to their rarity in the general population, these founders have been difficult to trace to a source. Here we show that all four major founders, ~40% of Ashkenazi mtDNA variation, have ancestry in prehistoric Europe, rather than the Near East or Caucasus. Furthermore, most of the remaining minor founders share a similar deep European ancestry. Thus the great majority of Ashkenazi maternal lineages were not brought from the Levant, as commonly supposed, nor recruited in the Caucasus, as sometimes suggested, but assimilated within Europe. These results point to a significant role for the conversion of women in the formation of Ashkenazi communities, and provide the foundation for a detailed reconstruction of Ashkenazi genealogical history.

Beyond the conventional: meeting the challenges of landscape governance within the European Landscape Convention?

PubMed

Scott, Alister

2011-10-01

Academics and policy makers seeking to deconstruct landscape face major challenges conceptually, methodologically and institutionally. The meaning(s), identity(ies) and management of landscape are controversial and contested. The European Landscape Convention provides an opportunity for action and change set within new governance agendas addressing interdisciplinarity and spatial planning. This paper critically reviews the complex web of conceptual and methodological frameworks that characterise landscape planning and management and then focuses on emerging landscape governance in Scotland within a mixed method approach involving policy analyses, semi-structured interviews and best practice case studies. Using Dower's (2008) criteria from the Articles of the European Landscape Convention, the results show that whilst some progress has been made in landscape policy and practice, largely through the actions of key individuals and champions, there are significant institutional hurdles and resource limitations to overcome. The need to mainstream positive landscape outcomes requires a significant culture change where a one-size-fits-all approach does not work. Copyright © 2011 Elsevier Ltd. All rights reserved.

Scientific Controversies in Teaching Science: The Case of Volta.

ERIC Educational Resources Information Center

Kipnis, Nahum

2001-01-01

Discusses a way of introducing a scientific controversy that emphasizes objective aspects of such issues as multiple theoretical interpretation of phenomena, choosing a theory, and insistence on the chosen theory. The goal is to give students a better insight into the workings of science and provide guidelines for building theories in their own…

The Animal Experimentation Controversy: Ethical Views of Prospective Teachers

ERIC Educational Resources Information Center

de Villiers, Rian

2012-01-01

Vivisection (live animal experimentation) is a controversial issue for many people. The purpose of this case study is to examine the attitudes of prospective teachers toward vivisection in education and research, to determine if gender has an influence on these attitudes, and to discuss the implications of these attitudes with regard to teaching…

The Reverse Discrimination Controversy. A Moral and Legal Analysis.

ERIC Educational Resources Information Center

Fullinwider, Robert K.

This book has two principal aims: to clarify the topical and controversial issue of reverse discrimination and to reach some conclusions about the rights and wrongs involved in this issue. Focusing mainly on preferential hiring, the book explicitly and extensively addresses the law and the institutional context of the issues. Examination of the…

Recent hospital charity care controversies highlight ambiguities and outdated features of government regulations.

PubMed

MacKelvie, Charles; Apolskis, Michael; Unland, James J

2005-01-01

For years the hospital industry has been embroiled in controversies involving pricing, charity care, and collection practices. Unfortunately, Medicare regulations and policies governing hospital charge-setting and collection practices have not helped bring much clarity to the situation, nor has related CMS and OIG guidance. Coordinated effort by hospitals and regulatory bodies can help clarify unclear government regulation of charity care, pricing, and collections and end potentially destructive controversies that sap valuable time, energy, and resources from efforts addressing much graver long-term threats to hospital viability.

The Validity of Observational Measures in Detecting Optimal Maternal Communication Styles: Evidence from European Americans and Latinos

ERIC Educational Resources Information Center

Nadeem, Erum; Romo, Laura F.; Sigman, Marian; Lefkowitz, Eva S.; Au, Terry K.

2007-01-01

This study examined the sensitivity of an observational coding system for assessing positive and negative maternal behaviors of Latino and European American mothers toward their adolescent children. Ninety Latino (54 Spanish speaking and 35 English speaking) and 20 European American mother-adolescent dyads participated in an observational study of…

Everything You Need To Know To Understand the Current Controversies You Learned from Psychological Research: A Comment on the Rind and Lilienfeld Controversies.

ERIC Educational Resources Information Center

Sternberg, Robert J.

2002-01-01

Discusses applications of theories and research in psychology to understand controversies generated by two recent articles, explaining the need to distinguish between rational and intuitive thinking, recognize the power of context, think reflectively, and realize the costs of defying the crowd, and noting steps one can take to be wiser and more…

Recommendation to increase the test concentration of methylchloroisothiazolinone/methylisothiazolinone in the European baseline patch test series - on behalf of the European Society of Contact Dermatitis and the European Environmental and Contact Dermatitis Research Group.

PubMed

Bruze, Magnus; Goossens, An; Isaksson, Marléne

2014-07-01

Methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) in aqua is present in the European baseline patch test series at 100 ppm, whereas 200 ppm has been used in Sweden since 1986, in Spain in the late 1980s, and, in recent years, also in the United Kingdom and Ireland. With regard to MCI/MI, to investigate the data on contact allergy rates in dermatitis patients, the frequencies of allergic contact dermatitis in the same group, and adverse reactions, particularly patch test sensitization in tested dermatitis patients, and to find the optimal patch test concentration as dose in mg/cm(2) . We performed a survey of the literature found via the National Library of Medicine (PubMed, http://www.ncbi.nlm.nih.gov/pubmed, last accessed 20 February 2014). MCI/MI at 200 ppm aq. diagnosis substantially more contact allergy and allergic contact dermatitis, without any registered increase in patch test sensitization, than the presently used concentration of 100 ppm. MCI/MI at 200 ppm aq. is recommended to be included in the European baseline patch test series. To avoid patch test sensitization, a dose of 0.006 mg/cm(2) must not be exceeded, which means a volume of 15 µl for Finn Chambers(®) (Ø 8 mm). © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Education Dept. to End Controversial Study of Upward Bound

ERIC Educational Resources Information Center

Field, Kelly

2008-01-01

Yielding to pressure from Congress and grant recipients, the U.S. Education Department has agreed to abandon a controversial evaluation of the Upward Bound (UB) college-preparation program. The study, which began last year, was designed to measure whether Upward Bound would have a bigger impact on college-going rates if it were refocused on…

Women, Webquests, and Controversial Issues in the Social Studies

ERIC Educational Resources Information Center

Crocco, Margaret Smith; Cramer, Judith

2005-01-01

America has been called "the argument culture," but you would not know it from many social studies classrooms. Despite a longstanding tradition in social studies of teaching controversial issues, all too few of today's classrooms accommodate this kind of intellectual activity. Perhaps it is the pressure of high stakes testing, or the emphasis on…

Before We Were Us, We Were Them: Curating Controversy

ERIC Educational Resources Information Center

Watson, Keri

2014-01-01

Prompted by the passage of Alabama House Bill 56, I organized the museum studies course I taught for Auburn University at Montgomery in the 2013 spring semester around an exhibition on immigration. The course offered the opportunity to engage students, faculty, and the community in discussion of an important, timely, and controversial topic.…

Medical students and controversial ethical issues: results from the multicenter study SBRAME.

PubMed

Lucchetti, Giancarlo; de Oliveira, Leandro Romani; Leite, José Roberto; Lucchetti, Alessandra Lamas Granero

2014-12-15

Medical students(MS) will face ethical issues throughout their lives as doctors. The present study aims to investigate medical students' opinions on controversial ethical issues and factors associated with these opinions. SBRAME (Spirituality and Brazilian Medical Education) is a multicenter study involving 12 Brazilian medical schools with 5950 MS. Participants completed a questionnaire that collected information on socio-demographic data, medical schools characteristics, religious beliefs and opinions on controversial ethical issues. Of all MS, 3630 participated in the survey (61.0%). The sample was 53.8% women and the mean age was 22.5 years. In general, most MS have no objections to prescription of birth control (90.8%), adult stem cell use (87.5%), embryonic stem cell use (82.0%) and abortion for genetic reasons (51.2%). Approximately half of students have no objections to human cloning (47.3%), 45.7% to withdrawal of artificial life support, 41.4% to euthanasia and 23.3% to abortion for failed contraception. Socio-demographic data such as age, gender and income had little influence on MS opinions. On the other hand, medical schools characteristics (number of medical students in the university, year of medical school foundation, location of the university and type of university) and religious aspects (religious affiliation, religious attendance, non-organizational religiousness and intrinsic religiousness) were highly correlated with their opinions. In general, MS with more supportive opinions on controversial ethical issues were less religious and from non-traditional (newer), urban, public and bigger universities. The current study reveals MS have different opinions regarding controversial ethical issues. Noteworthy, these opinions seem to be shaped more by university characteristics and religious beliefs than socio-demographic data.

Non-animal sensitization testing: state-of-the-art.

PubMed

Vandebriel, Rob J; van Loveren, Henk

2010-05-01

Predictive tests to identify the sensitizing properties of chemicals are carried out using animals. In the European Union timelines for phasing out many standard animal tests were established for cosmetics. Following this policy, the new European Chemicals Legislation (REACH) favors alternative methods, if validated and appropriate. In this review the authors aim to provide a state-of-the art overview of alternative methods (in silico, in chemico, and in vitro) to identify contact and respiratory sensitizing capacity and in some occasions give a measure of potency. The past few years have seen major advances in QSAR (quantitative structure-activity relationship) models where especially mechanism-based models have great potential, peptide reactivity assays where multiple parameters can be measured simultaneously, providing a more complete reactivity profile, and cell-based assays. Several cell-based assays are in development, not only using different cell types, but also several specifically developed assays such as three-dimenionally (3D)-reconstituted skin models, an antioxidant response reporter assay, determination of signaling pathways, and gene profiling. Some of these assays show relatively high sensitivity and specificity for a large number of sensitizers and should enter validation (or are indeed entering this process). Integrating multiple assays in a decision tree or integrated testing system is a next step, but has yet to be developed. Adequate risk assessment, however, is likely to require significantly more time and efforts.

Skin diseases associated with Malassezia yeasts: facts and controversies.

PubMed

Gaitanis, Georgios; Velegraki, Aristea; Mayser, Peter; Bassukas, Ioannis D

2013-01-01

The implication of the yeast genus Malassezia in skin diseases has been characterized by controversy, since the first description of the fungal nature of pityriasis versicolor in 1846 by Eichstedt. This is underscored by the existence of Malassezia yeasts as commensal but also by their implication in diseases with distinct absence of inflammation despite the heavy fungal load (pityriasis versicolor) or with characteristic inflammation (eg, seborrheic dermatitis, atopic dermatitis, folliculitis, or psoriasis). The description of 14 Malassezia species and subsequent worldwide epidemiologic studies did not reveal pathogenic species but rather disease-associated subtypes within species. Emerging evidence demonstrates that the interaction of Malassezia yeasts with the skin is multifaceted and entails constituents of the fungal wall (melanin, lipid cover), enzymes (lipases, phospholipases), and metabolic products (indoles), as well as the cellular components of the epidermis (keratinocytes, dendritic cells, and melanocytes). Understanding the complexity of their interactions will highlight the controversies on the clinical presentation of Malassezia-associated diseases and unravel the complexity of skin homeostatic mechanisms. Copyright © 2013 Elsevier Inc. All rights reserved.

Playful biometrics: controversial technology through the lens of play.

PubMed

Ellerbrok, Ariane

2011-01-01

This article considers the role of play in the context of technological emergence and expansion, particularly as it relates to recently emerging surveillance technologies. As a case study, I consider the trajectory of automated face recognition—a biometric technology of numerous applications, from its more controversial manifestations under the rubric of national security to a clearly emerging orientation toward play. This shift toward “playful” biometrics—or from a technology traditionally coded as “hard” to one now increasingly coded as “soft”—is critical insofar as it renders problematic the traditional modes of critique that have, up until this point, challenged the expansion of biometric systems into increasingly ubiquitous realms of everyday life. In response to this dynamic, I propose theorizing the expansion of face recognition specifically in relation to “play,” a step that allows us to broaden the critical space around newly emerging playful biometrics, as well as playful surveillance more generally. In addition, play may also have relevance for theorizing other forms of controversial technology, particularly given its potential role in processes of obfuscation, normalization, and marginalization.

Teaching Controversial Issues in the JLL Classroom for Chinese Students

ERIC Educational Resources Information Center

Shimojimai, Yasuko

2017-01-01

This paper discusses how teachers explore teaching controversial issues in the Japanese language classroom to Japanese language learner (JLL) or culturally and linguistically diverse (CLD) students who have different cultural and political backgrounds. Assuring educational opportunities with consideration of JLLs' background is important…

Is there a sensitive period in human incest avoidance?

PubMed

Luo, Liqun

2011-06-24

Many studies support the proposition that early cosocialization with opposite-sex children has the effect of inhibiting later mutual sexual attraction, but the existence of a period in the life cycle in which individuals are sensitive to the effect of early cosocialization has been a matter of controversy. Drawing on earlier traditional psychological research, and on more recent work guided by parental investment theory, we hypothesized that only for maternal perinatal association (MPA)-absent males a less-than- around-three-years age difference with the sister can predict stronger aversion to sibling incest. The results corroborated the hypothesis. The results can be interpreted as support for the existence of a sensitive period as well as for the potent role of MPA. Cross-cultural comparative studies were called on to further test the hypothesis.

Interfacing of Science, Medicine and Law: The Stem Cell Patent Controversy in the United States and the European Union.

PubMed

Davey, Sonya; Davey, Neil; Gu, Qian; Xu, Na; Vatsa, Rajet; Devalaraja, Samir; Harris, Paul; Gannavaram, Sreenivas; Dave, Raj; Chakrabarty, Ananda

2015-01-01

The patent eligibility of stem cells-particularly those derived from human embryos-has long been under debate in both the scientific and legal communities. On the basis of moral grounds, the European Patent Office (EPO) has refrained from granting patents for stem cells obtained through the destruction of human embryos. On the contrary, the United States Patent and Trademark Office (USPTO) has historically granted patents regarding the isolation and use of human embryonic and other stem cells. To date, these US patents remain valid despite an increasing onslaught of challenges in court. However, recent precedents established in US courts significantly narrow the scope of patent eligibility within biotechnology. This article compares the implications of recent legal changes on stem cell patent eligibility between the EU and US.

Staggering successes amid controversy in California water management

NASA Astrophysics Data System (ADS)

Lund, J. R.

2012-12-01

Water in California has always been important and controversial, and it probably always will be. California has a large, growing economy and population in a semi-arid climate. But California's aridity, hydrologic variability, and water controversies have not precluded considerable economic successes. The successes of California's water system have stemmed from the decentralization of water management with historically punctuated periods of more centralized strategic decision-making. Decentralized management has allowed California's water users to efficiently explore incremental solutions to water problems, ranging from early local development of water systems (such as Hetch Hetchy, Owens Valley, and numerous local irrigation projects) to more contemporary efforts at water conservation, water markets, wastewater reuse, and conjunctive use of surface and groundwater. In the cacophony of local and stakeholder interests, strategic decisions have been more difficult, and consequently occur less frequently. California state water projects and Sacramento Valley flood control are examples where decades of effort, crises, floods and droughts were needed to mobilize local interests to agree to major strategic decisions. Currently, the state is faced with making strategic environmental and water management decisions regarding its deteriorating Sacramento-San Joaquin Delta. Not surprisingly, human uncertainties and physical and fiscal non-stationarities dominate this process.

Fetal abuse and neglect: an emerging controversy.

PubMed

Landwirth, J

1987-04-01

Advances in fetal medicine have expanded opportunities for protection of fetal health and intrauterine management of an increasing number of fetal disorders. The legal rights and duties of parents to provide necessary medical treatment for the child may extend to the prenatal period. Resolution of the conflict between the rights of the fetus to be born healthy and the pregnant woman's right of privacy is difficult and controversial. It is suggested that intrusion into a woman's individual fundamental rights for the potential benefit of her fetus should be permissible only in narrowly defined circumstances.

Antivenoms for snakebite: design, function, and controversies.

PubMed

Lavonas, Eric J

2012-08-01

Animal-derived antivenoms have been used to treat snake envenomation for more than 100 years. Major technological advantages in the past 30 years have produced antivenoms that are highly purified and chemically modified to reduce the risk of acute hypersensitivity reactions. Like all pharmaceutical manufacture, commercial-scale antivenom production requires making trade-offs between cost, purity, pharmacokinetic profile, and production yield. This article reviews the current state of the art for antivenom production and development. Particular attention is paid to controversies and trade-offs used to achieve a balance between improved safety and pharmacokinetic performance.

The Emergence of the Controversy around the Theory of Evolution and Creationism in UK Newspaper Reports

ERIC Educational Resources Information Center

Allgaier, Joachim; Holliman, Richard

2006-01-01

The question of whether religious explanations about the origin of life should be taught alongside scientific accounts in compulsory science education has sparked controversy in several countries for decades. An important site for these controversies is media reporting. This article presents the results of a quantitative and qualitative analysis…

Millennia of Discord: The Controversial Educational Program of Isocrates

ERIC Educational Resources Information Center

Marsh, Charles

2010-01-01

Five years ago in "Theory and Research in Education", James R. Muir fired a new salvo in the debate regarding the merits of Isocrates' educational program, a controversy that has endured for more than two millennia. Was the Isocratean program misguided and lowbrow, as in the estimations of Plato and Aristotle--or was it the most successful program…

Creationism in the Classroom: A Controversy with Serious Consequences

ERIC Educational Resources Information Center

Baker, Sylvia

2010-01-01

The resignation of the Revd Professor Michael Reiss from his position as Director of Education at the Royal Society over the issue of the teaching of creationism in school science classes provides the background to this article. The immediate controversy is described and considered in relation to its wider context and to the serious questions that…

The Evolution/Creation Science Controversy: Educate Rather Than Debate.

ERIC Educational Resources Information Center

Jane, Beverley

This paper is linked to the theme History and Philosophy of Science. The Evolution and creation science controversy is now in the general public's arena and poses a challenge for school science. The paper begins by briefly describing the current situation concerning this issue in Australia and the United States of America. In the subject Biology,…

Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe.

PubMed

Mothes-Luksch, N; Raith, M; Stingl, G; Focke-Tejkl, M; Razzazi-Fazeli, E; Zieglmayer, R; Wöhrl, S; Swoboda, I

2017-09-01

In the Mediterranean area, lipid transfer proteins (LTPs) are important causes of plant-food allergies often associated with severe allergic reactions. There, peach LTP (Pru p 3) seems to be the primary sensitizer, whereas in Central Europe, little is known about the importance of LTP sensitization. In this region, allergen extract-based diagnosis is often complicated by co-sensitization to Bet v 1, the major birch pollen allergen, its cross-reactive food allergens, and profilins. We investigated the role of LTP sensitization in Central European patients displaying strong allergic reactions to plant-derived food. Analysis of IgE reactivity revealed that ten of thirteen patients were sensitized to Pru p 3, nine to Bet v 1, and two to profilin. Our results showed that LTP sensitization represents a risk factor for severe allergic symptoms in Central Europe. Furthermore, the strong IgE reactivity detected in immunoblots of plant-food extracts indicated that Pru p 3 can be used as a marker allergen for LTP sensitization also in Central European patients. © 2017 The Authors Allergy Published by John Wiley & Sons Ltd.

Climate Change Impairs Nitrogen Cycling in European Beech Forests.

PubMed

Dannenmann, Michael; Bimüller, Carolin; Gschwendtner, Silvia; Leberecht, Martin; Tejedor, Javier; Bilela, Silvija; Gasche, Rainer; Hanewinkel, Marc; Baltensweiler, Andri; Kögel-Knabner, Ingrid; Polle, Andrea; Schloter, Michael; Simon, Judy; Rennenberg, Heinz

2016-01-01

European beech forests growing on marginal calcareous soils have been proposed to be vulnerable to decreased soil water availability. This could result in a large-scale loss of ecological services and economical value in a changing climate. In order to evaluate the potential consequences of this drought-sensitivity, we investigated potential species range shifts for European beech forests on calcareous soil in the 21st century by statistical species range distribution modelling for present day and projected future climate conditions. We found a dramatic decline by 78% until 2080. Still the physiological or biogeochemical mechanisms underlying the drought sensitivity of European beech are largely unknown. Drought sensitivity of beech is commonly attributed to plant physiological constraints. Furthermore, it has also been proposed that reduced soil water availability could promote nitrogen (N) limitation of European beech due to impaired microbial N cycling in soil, but this hypothesis has not yet been tested. Hence we investigated the influence of simulated climate change (increased temperatures, reduced soil water availability) on soil gross microbial N turnover and plant N uptake in the beech-soil interface of a typical mountainous beech forest stocking on calcareous soil in SW Germany. For this purpose, triple 15N isotope labelling of intact beech seedling-soil-microbe systems was combined with a space-for-time climate change experiment. We found that nitrate was the dominant N source for beech natural regeneration. Reduced soil water content caused a persistent decline of ammonia oxidizing bacteria and therefore, a massive attenuation of gross nitrification rates and nitrate availability in the soil. Consequently, nitrate and total N uptake of beech seedlings were strongly reduced so that impaired growth of beech seedlings was observed already after one year of exposure to simulated climatic change. We conclude that the N cycle in this ecosystem and here

Climate Change Impairs Nitrogen Cycling in European Beech Forests

PubMed Central

Dannenmann, Michael; Bilela, Silvija; Gasche, Rainer; Hanewinkel, Marc; Baltensweiler, Andri; Kögel-Knabner, Ingrid; Polle, Andrea; Schloter, Michael; Simon, Judy; Rennenberg, Heinz

2016-01-01

European beech forests growing on marginal calcareous soils have been proposed to be vulnerable to decreased soil water availability. This could result in a large-scale loss of ecological services and economical value in a changing climate. In order to evaluate the potential consequences of this drought-sensitivity, we investigated potential species range shifts for European beech forests on calcareous soil in the 21st century by statistical species range distribution modelling for present day and projected future climate conditions. We found a dramatic decline by 78% until 2080. Still the physiological or biogeochemical mechanisms underlying the drought sensitivity of European beech are largely unknown. Drought sensitivity of beech is commonly attributed to plant physiological constraints. Furthermore, it has also been proposed that reduced soil water availability could promote nitrogen (N) limitation of European beech due to impaired microbial N cycling in soil, but this hypothesis has not yet been tested. Hence we investigated the influence of simulated climate change (increased temperatures, reduced soil water availability) on soil gross microbial N turnover and plant N uptake in the beech-soil interface of a typical mountainous beech forest stocking on calcareous soil in SW Germany. For this purpose, triple 15N isotope labelling of intact beech seedling-soil-microbe systems was combined with a space-for-time climate change experiment. We found that nitrate was the dominant N source for beech natural regeneration. Reduced soil water content caused a persistent decline of ammonia oxidizing bacteria and therefore, a massive attenuation of gross nitrification rates and nitrate availability in the soil. Consequently, nitrate and total N uptake of beech seedlings were strongly reduced so that impaired growth of beech seedlings was observed already after one year of exposure to simulated climatic change. We conclude that the N cycle in this ecosystem and here

42 CFR 405.745 - Amount in controversy ascertained after reconsideration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 2 2011-10-01 2011-10-01 false Amount in controversy ascertained after reconsideration. 405.745 Section 405.745 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED...

"We Make It Controversial": Elementary Preservice Teachers' Beliefs about Race

ERIC Educational Resources Information Center

Buchanan, Lisa Brown

2015-01-01

The impetus for this study began during an elementary teacher education course meeting, where preservice teachers discussed whether or not it was appropriate to discuss controversial topics--including race--with young children. Preservice teachers disclosed their "uncomfortableness" with race at large, and emphasized that discussions…

Challenges and Controversies of Foot and Ankle Trauma.

PubMed

Taghavi, Cyrus E; Sandlin, Michael Isiah; Thordarson, David B

2017-02-15

Traumatic injury to the foot and ankle can result in long-term disability, which may have substantial negative implications on a patient's functional outcomes and quality of life. The diagnosis and appropriate management of these challenging injuries are not always agreed on or straightforward. In particular, the appropriate diagnosis and management of distal tibiofibular syndesmotic injuries as well as the surgical approach and role of primary subtalar arthrodesis for intra-articular calcaneal fractures are controversial.

"Treason in the Textbooks": Reinterpreting the Harold Rugg Textbook Controversy in the Context of Wartime Schooling

ERIC Educational Resources Information Center

Dorn, Charles

2008-01-01

For most educational historians, the Harold Rugg textbook controversy serves as an example of the mid-twentieth-century "assault" on progressive education. By restricting their analyses of the textbook controversy to the "rise and fall" of the progressivism paradigm, however, scholars have generally missed Americans' more measured approach to the…

[Controversies regarding distribution, instrumentation, and competence of hemodynamics laboratories].

PubMed

Olivari, Z; Piccolo, E

2001-01-01

In the last few years we have witnessed a substantial growth in the number of catheterization laboratories, especially in the northern regions of Italy, a phenomenon which has met some controversy and has been discussed in a Symposium at the ANMCO National Conference (Florence, May 20-23, 2000). The controversy is essentially between those who believe in the implementation of catheterization laboratories in all cardiology units equipped with a cardiological intensive care unit (and the creation of a functional network with the tutorial centers) and those who refer to the existing guidelines, standards and VRQ which envisage a geographical distribution of laboratories on the basis of a balance between needs of the population and the minimum quantity of procedures performed by each center in order to guarantee the best quality and cost-effectiveness. The aim of the Symposium was to clarify whether the two "innovations" of these last few years, namely the introduction of new portable radiological equipment on the one hand and the effectiveness of primary angioplasty in the treatment of acute myocardial infarction on the other, may influence the redefinition of criteria regarding the distribution of laboratories, taking into account as well the expansion of indications for coronary angioplasty and coronary angiography. After a lively discussion, the proceedings can be summed up as follows: no agreement was reached regarding the role of portable radiological equipment in the decisional process regarding the setting up of a new catheterization laboratory; primary angioplasty should be carried out in centers with an adequate volume of activity and a functioning inter-hospital organizational structure for this demanding activity; otherwise it does not offer any advantages over fibrinolytic therapy; the proposal of a new organizational model is based on the creation of transverse inter-hospital cardiology departments, the size of which is based on the overall size of the

The advantage and disadvantage of peripheral ignorance: the gas adsorption controversy.

PubMed

Palló, Gábor

2010-07-01

In the early history of surface chemistry, in the 1920s, the nature of gas adsorption was a pivotal subject. A theory created by Michael Polanyi in the peripheral Hungary contradicted the received view originating from the American Irving Langmuir. When working out his theory, Polanyi had not even heard of Langmuir's rival description. However, Polanyi emigrated from Hungary to Germany, the centre of his field, and tried to defend his adsorption theory in the circle of the leading experts, including Einstein and Fritz Haber. This controversy seemed vital to his survival as a scientist and as an immigrant. The aim of this article is to recapitulate this controversy, with its sad undercurrents, the role of local science, methods of argumentation, and the work of a central scientific community.

[On controversies around the Oedipus Complex].

PubMed

Drwiega, Marek

2002-01-01

In the article the author would like to draw the readers' attention to one of the central issues of psychoanalysis, i.e. Oedipus complex. In the development of the psychoanalysis the classical conception of Oedipus complex presented by Freud gave rise to a severe criticism both on the part of some psychoanalysts, especially women such as e.g. Melanie Klein, and on the part of ethnographers such as B. Malinowski. In the paper the author presents the main controversies concerning this interesting discussion. The fact of the matter is that the Oedipus complex is a hotly debated subject, not only from the cultural point of view but also within the psychoanalytical movement.

The Legitimizing Function of Judicial Rhetoric in the Eugenics Controversy.

ERIC Educational Resources Information Center

Hasian, Marouf, Jr.; Croasmun, Earl

1992-01-01

Investigates the possibility that judicial policymaking is responsive to the situational exigencies created in part through public discourse. Investigates the elite and public perspectives regarding the eugenics controversy in the 1920s to explore the emergent relationship between the public and technical spheres of argument. (SR)

Communications Contingency Plan: Planning for Crises and Controversy. Phase 1

NASA Technical Reports Server (NTRS)

Treise, Deborah; Bernstein, Arla G.; Yates, Brad

1998-01-01

Interviews were conducted with a variety of Marshall Space Flight Center personnel and local media representatives in Huntsville, Alabama, in order to identify the current perceptions of these individuals regarding communication effectiveness between MSFC and the media. The purposes of the Phase One report are to (1) assess the need for a contingency plan for communicating in situations of crisis and controversy; (2) identify goals and objectives for the planning process; and (3) provide recommendations for future planning activities to achieve the goals and objectives outlined in Phase One. It is strongly recommended that MSFC personnel who are involved in communications with the media participate in a facilitated, strategic communications planning process in order to develop Phase Two of the Communications Contingency Plan (CCP). Phase Two will address (1) the categorizing, ranking and prioritizing of crises and controversies; (2) the development of action steps and implementation strategies for the CCP; and (3) the development of a monitoring and evaluation process for ongoing plan effectiveness.

Questions and controversies: the role of necroptosis in liver disease

PubMed Central

Dara, Lily; Liu, Zhang-Xu; Kaplowitz, Neil

2016-01-01

Acute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the liver from acute liver failure, and in chronic injury, to curb secondary inflammation and fibrosis, is of paramount importance as a therapeutic strategy. Both apoptosis and necrosis occur in the liver, but the occurrence of necroptosis in the liver and its contribution to liver disease is controversial. Necroptosis is a form of regulated necrosis which occurs in certain cell types when caspases (+/−cIAPs) are inhibited through the RIPK1-RIPK3 activation of MLKL. The occurrence of necroptosis in the liver has recently been examined in multiple liver injury models with conflicting results. The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field. PMID:27924226

A substantial prehistoric European ancestry amongst Ashkenazi maternal lineages

PubMed Central

Costa, Marta D.; Pereira, Joana B.; Pala, Maria; Fernandes, Verónica; Olivieri, Anna; Achilli, Alessandro; Perego, Ugo A.; Rychkov, Sergei; Naumova, Oksana; Hatina, Jiři; Woodward, Scott R.; Eng, Ken Khong; Macaulay, Vincent; Carr, Martin; Soares, Pedro; Pereira, Luísa; Richards, Martin B.

2013-01-01

The origins of Ashkenazi Jews remain highly controversial. Like Judaism, mitochondrial DNA is passed along the maternal line. Its variation in the Ashkenazim is highly distinctive, with four major and numerous minor founders. However, due to their rarity in the general population, these founders have been difficult to trace to a source. Here we show that all four major founders, ~40% of Ashkenazi mtDNA variation, have ancestry in prehistoric Europe, rather than the Near East or Caucasus. Furthermore, most of the remaining minor founders share a similar deep European ancestry. Thus the great majority of Ashkenazi maternal lineages were not brought from the Levant, as commonly supposed, nor recruited in the Caucasus, as sometimes suggested, but assimilated within Europe. These results point to a significant role for the conversion of women in the formation of Ashkenazi communities, and provide the foundation for a detailed reconstruction of Ashkenazi genealogical history. PMID:24104924

Chlorine: Undergraduate Research on an Element of Controversy

NASA Astrophysics Data System (ADS)

Chang, Hasok

2009-04-01

If chemical elements were people, chlorine would be a celebrity. Although intrinsically no more or less important than any other element, chlorine has had a knack of making headlines. The genre of "object biography" has been quite successful in popular science recently. We took this opportunity to write a "biographical" study of chlorine. Chlorine's wide range of interesting controversies is well suited for attracting and maintaining the enthusiasm of the diverse range of students we teach in our department.

Ethical Perspectives on the Current Controversy Regarding Openness in Adoption.

ERIC Educational Resources Information Center

Tavis, Timothy M.

This paper outlines current changes in American adoption practice and the controversies surrounding these changes. It includes a discussion of the role that neo-Kantian and utilitarian perspectives have played in American adoption policy and practice, and offers an alternative, the communitarian perspective, described by Sandel (1984). Adoption…

SCHOOL INTEGRATION CONTROVERSIES IN NEW YORK CITY, A PILOT STUDY.

ERIC Educational Resources Information Center

SWANSON, BERT E.

THE MAJOR PROBLEM OF THIS PREPARATORY RESEARCH PROGRAM WAS TO ASCERTAIN THE FEASIBILITY OF MAKING A FULL-SCALE STUDY OF THE DYNAMICS OF SCHOOL INTEGRATION CONTROVERSIES IN NEW YORK CITY. METHODS INVOLVED INTERVIEWING AND OBSERVING LEADERS AT CITYWIDE AND NEIGHBORHOOD LEVELS, INCLUDING SCHOOL ADMINISTRATORS, SCHOOL BOARD MEMBERS, TEACHERS, PARENT…

Information, education, and health behaviors: Evidence from the MMR vaccine autism controversy.

PubMed

Chang, Lenisa V

2018-05-02

In the wake of strong, although later refuted, claims of a link between autism and the measles-mumps-rubella (MMR) vaccine, I examine whether fewer parents immunized or delayed vaccinations for their children and if there was a differential response by mother's education level. Using various controls and a differencing strategy that compares in MMR take-up with other vaccines, I find that the MMR-autism controversy led to a decline in the immediate years and that there were negative spillovers onto other vaccines. I also find evidence that more highly educated mothers responded more strongly to the controversy either by not immunizing their children altogether or, to a lesser degree, delaying vaccination. Moreover, the educational gap was greater in states where there was greater media attention devoted to the controversy. This is consistent with the health allocative efficiency hypothesis whereby part of the education gradient in health outcomes is due to more-educated individuals absorbing and responding to health information more quickly. However, unlike in the United Kingdom, where previous studies find that the gap was eliminated after the link was refuted, the evidence for the United States suggests that the educational gap persisted. Copyright © 2018 John Wiley & Sons, Ltd.

"There is Space, and There are Limits": The Challenge of Teaching Controversial Topics in an Illiberal Democracy

ERIC Educational Resources Information Center

Ho, Li-Ching; Alviar-Martin, Theresa; Leviste, Enrique Niño P.

2014-01-01

Background/Context: Research indicates that across democratic societies, teachers face numerous intellectual and emotional challenges when handling controversial topics in the classroom. Less attention, however, has been paid to how teachers' willingness to teach controversial topics intersects with political and other societal factors in…

J Wave Syndromes: History and Current Controversies

PubMed Central

Liu, Tong; Zheng, Jifeng

2016-01-01

The concept of J wave syndromes was first proposed in 2004 by Yan et al for a spectrum of electrocardiographic (ECG) manifestations of prominent J waves that are associated with a potential to predispose affected individuals to ventricular fibrillation (VF). Although the concept of J wave syndromes is widely used and accepted, there has been tremendous debate over the definition of J wave, its ionic and cellular basis and arrhythmogenic mechanism. In this review article, we attempted to discuss the history from which the concept of J wave syndromes (JWS) is evolved and current controversies in JWS. PMID:27721848

Culture and context: East Asian American and European American differences in P3 event-related potentials and self-construal.

PubMed

Lewis, Richard S; Goto, Sharon G; Kong, Lauren L

2008-05-01

Research has demonstrated differences in social and cognitive processes between East Asians and European Americans. Whereas East Asians have been characterized as being more sensitive to situational context and attending more to the perceptual field, European Americans have been characterized as being more focused on the object and being more field independent. The goal of the present experiment was to investigate differences in neural responses to target objects and stimulus context between East Asian Americans and European Americans using a three-stimulus novelty P3 event-related potential design. As hypothesized, European Americans displayed relatively greater target P3 amplitudes, indexing attention to target events, whereas East Asian Americans displayed relatively greater novelty P3 amplitudes, indexing attention to contextually deviant events. Furthermore, the authors found that interdependent self-construal mediated the relationship between culture and the novelty P3. These findings identify a specific pattern of neural activity associated with established cultural differences in contextual sensitivity.

Botswana alcohol policy and the presidential levy controversy.

PubMed

Pitso, Joseph M N; Obot, Isidore S

2011-05-01

To assess the state of alcohol policy in Botswana in the context of a substantial levy imposed on alcohol sales by the President. DESIGN, MEASUREMENTS: Analysis of policy documents and media reports to describe the drivers of policy formation. Botswana. Legislation aimed at addressing the problem of excessive consumption of alcohol in the country has been proposed and enacted since independence in 1966 and a draft national alcohol policy is currently being debated. The policy recognizes the need to protect the rights of adult citizens of Botswana to purchase and consume alcohol in a safe and well-regulated manner and the role of government in ensuring that vulnerable members of the community are protected against the impact of harmful use of alcohol. In 2008, controversy erupted over the proposal by the President of the country to impose a 70% levy on alcohol products, later reduced to 30%. The industry responded by threatening to go to court and has since focused their response on what they claim to be serious economic losses due to reduced consumption of their products. The ongoing controversy in Botswana calls attention to the role of the industry in influencing the debate on alcohol and the need to keep in mind overall public health interest in efforts to develop and implement a national alcohol policy. © 2011 The Authors, Addiction © 2011 Society for the Study of Addiction.

D. W. Griffith's Controversial Film, "The Birth of a Nation."

ERIC Educational Resources Information Center

Pitcher, Conrad

1999-01-01

Presents a lesson plan that enables students to investigate race relations during the Progressive Era by analyzing D. W. Griffith's "The Birth of a Nation" and the controversy surrounding the release of the film. Explores the pros and cons of using motion pictures as teaching tool. Includes two student handouts. (CMK)

Evolution of the Two Cultures controversy

NASA Astrophysics Data System (ADS)

Bieniek, Ronald J.

1981-05-01

The Two Cultures schism is a persistent problem in our society. For over a century, scientific spokesmen and literary critics, from T. H. Huxley and M. Arnold to C. P. Snow and F. R. Leavis, have been involved in the Two Cultures issue. This article examines the evolution of the controversy between the ''scientific'' and ''humanistic'' elements of Western culture and its relation to educational policies. The division and antagonism between these two cultures appears to have arisen from differences in the human attitudes that they are preceived to engender. ''Scientific'' professionalism has been associated with a progressive optimism and self-assurance that nurture a broad humanitarianism, while the ''literary'' tradition is characterized by restraint, acceptance, and a more selective humanism.

Surgical training and the European Working Time Directive: The role of informal workplace learning.

PubMed

Giles, James A

2010-01-01

The introduction of European Working Time Directive, limiting doctors' working hours to 48 per week, has caused recent controversy within the profession. The Royal College of Surgeons of England in particular has been one of the loudest critics of the legislation. One of the main concerns is regarding the negative impact on training hours for those embarking on surgical careers. Simulation technology has been suggested as a method to overcome this reduction in hospital training hours, and research suggests that this is a good substitute for operative training in a theatre. However, modern educational theory emphasises the power of informal workplace learning in postgraduate education, and the essential role of experience in training future surgeons. Copyright 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

The Controversy Over Ability Grouping in American Education, 1916-1970.

ERIC Educational Resources Information Center

McDermott, John W., Jr.

This study traces the controversy over the classification of children according to their ability from its origins in the development of the mental testing movement after 1916. The campaign to organize the schools largely on the basis of standardized tests of intelligence drew substantial support after 1920 from the development of research bureaus…

Improving the Quality of Science Classroom Discourse on Controversial Issues.

ERIC Educational Resources Information Center

Geddis, Arthur N.

1991-01-01

Illustrates how the sophistication of students' discussion on controversial issues can be increased by explicit attention to (1) the defensibility of more than one position, and (2) the relationship between protagonist's interests and the positions adopted. Presents a case study of a teacher using this scheme as he reflects on and modifies his…

Pulse oximeter saturation target limits for preterm infants: a survey among European neonatal intensive care units.

PubMed

Huizing, Maurice J; Villamor-Martínez, Eduardo; Vento, Máximo; Villamor, Eduardo

2017-01-01

The optimum range of pulse oximeter oxygen saturation (SpO 2 ) for preterm infants remains controversial. Between November 2015 and February 2016, we conducted a web-based survey aimed to investigate the current and former practices on SpO 2 targets in European neonatal intensive care units (NICUs). We obtained valid responses from 193 NICUs, treating 8590 newborns ≤28 weeks per year, across 27 countries. Forty different saturation ranges were reported, ranging from 82-93 to 94-99%. The most frequently utilized SpO 2 ranges were 90-95% (28%), 88-95% (12%), 90-94% (5%), and 91-95% (5%). A total of 156 NICUs (81%) changed their SpO 2 limits over the last 10 years. The most frequently reported former limits were 88-92% (18%), 85-95% (9%), 88-93 (7%), and 85-92% (6%). The NICUs that increased their SpO 2 ranges expected to obtain a reduction in mortality. A 54% of the NICUs found the scientific evidence supporting their SpO 2 targeting policy strong or very strong. We detected a high degree of heterogeneity in pulse oximeter SpO 2 target limits across European NICUs. The currently used limits are 3 to 5% higher than the former limits, and the most extreme limits, such as lower below 85% or upper above 96%, have almost been abandoned. What is Known: • For preterm infants requiring supplemental oxygen, the optimum range of pulse oximeter oxygen saturation (SpO 2 ) to minimize organ damage, without causing hypoxic injury, remains controversial. What is New: • This survey highlights the lack of consensus regarding SpO 2 target limits for preterm infants among European neonatal intensive care units (NICUs). We detected 40 different SpO 2 ranges, and even the most frequently reported range (i.e., 90-95%) was used in only 28% of the 193 respondent NICUs. • A total of 156 NICUs (81%) changed their SpO 2 limits over the last 10 years. The currently used limits are 3 to 5% higher than the former limits, and the most extreme limits, such as lower below 85% or upper

How medical specialists appraise three controversial health innovations: scientific, clinical and social arguments.

PubMed

Lehoux, Pascale; Denis, Jean-Louis; Rock, Melanie; Hivon, Myriam; Tailliez, Stephanie

2010-01-01

Medical specialists play a pivotal role in health innovation evaluation and policy making. Their influence derives not only from their expertise, but also from their social status and the power of their professional organisations. Little is known, however, about how medical specialists determine what makes a health innovation desirable and why. Our qualitative study investigated the views of 28 medical specialists and experts from Quebec and Ontario (Canada) on three controversial innovations: electroconvulsive therapy, prostate-specific antigen screening and prenatal screening for Down's syndrome. Our findings indicate that the scientific, clinical and social arguments of medical specialists combine to create a relatively consistent narrative for each innovation. Our comparative analysis suggests that these narratives bring about a 'soft' resolution to controversies, which relies on a more or less tacit understanding of the social desirability of innovations and which sets the stage for their routinisation. Such an unpacking of medical specialists' arguments both for and against new technologies is needed because such arguments may easily be considered authoritative and because there are few forums for debating the social desirability of innovations not generally deemed to be highly controversial.

Is the European standard series suitable for patch testing in Riyadh, Saudi Arabia?

PubMed

el-Rab, M O; al-Sheikh, O A

1995-11-01

Due to the lack of a regional patch test series in our geographical area, the suitability of the European standard series was evaluated by patch testing dermatitis patients in Riyadh, Saudi Arabia. Of 240 consecutive patients with various forms of dermatitis, 136 (57%) showed 1 or more positive patch tests, women, 74 (54%), slightly outnumbering men, 62 (46%). Positive reactions were found to 21 of the 22 items in the test series. Sensitization was most common to nickel sulfate (51 = 37.5%), potassium dichromate (48 = 35%) and cobalt chloride (43 = 32%) The frequency of sensitization to nickel was higher in women (41 = 30%) while that to dichromate was higher in men (39 = 29%). Less reactions were found to fragrance mix (21 = 15%), formaldehyde (15 = 11%) and neomycin sulfate (15 = 11%). Sensitization to other allergens ranged between 10 and 1%. Less than 1% of patients (0.7%) reacted to benzocaine and none to primin. The frequency of occurrence of multiple sensitivities is also presented. We conclude that the European standard series is suitable for patch testing dermatitis patients in our region, with the exception of benzocaine and primin. The addition of 3 allergens that could be of local relevance is discussed.

Government Regulation of the Pursuit of Knowledge: The Recombinant DNA Controversy.

ERIC Educational Resources Information Center

Berger, Richard G.

1978-01-01

Government regulation of recombinant DNA research is addressed. Issues discussed include the potential of such research; National Institutes of Health guidelines; federal, state, and local regulation; the controversy over self-regulation; first amendment protection for scientific research; and problems in drafting legislation. (JMD)

Controversial Practices: The Need for a Reacculturation of Early Intervention Fields.

ERIC Educational Resources Information Center

McWilliam, R. A.

1999-01-01

Identifies characteristics (such as cure claims, practitioner specialization, and questionable research) of controversial practices in early intervention. Evaluates 13 such practices grouped into medical, educational, and therapeutic categories and suggests reasons that professionals and parents adopt such practices. Suggestions for the field…

Moral Controversy, Directive Counsel, and the Doctor’s Role: Findings From a National Survey of Obstetrician–Gynecologists

PubMed Central

Yoon, John D.; Rasinski, Kenneth A.; Curlin, Farr A.

2013-01-01

Purpose To explore physicians’ attitudes toward providing directive counsel when dealing with morally controversial medical decisions, and to examine associations between physicians’ opinions and their demographic and religious characteristics. Method In 2008–2009, the authors mailed a survey to a stratified, random sample of 1,800 U.S. obstetrician–gynecologists. They asked participants whether, when dealing with either typical or morally controversial medical decisions, “a physician should encourage patients to make the decision that the physician believes is best.” Results Among eligible physicians, the response rate was 66%. Fifty-four percent of respondents rejected the use of directive counsel for typical medical decisions; 78% did so for morally controversial medical decisions. Physicians were less likely to refrain from directive counsel for typical medical decisions if they were older and foreign-born but more likely to refrain from directive counsel if they were more theologically pluralistic. Theological pluralism was the only characteristic significantly associated with refraining from directive counsel for morally controversial medical decisions. Conclusions Providing nondirective counsel to their patients appears to have become the norm among certain obstetrician–gynecologists in the United States, particularly when dealing with morally controversial medical decisions. These physicians tend to be female, younger, U.S.-born, and more theologically pluralistic. Shifts toward refraining from directive counsel seem to relate to shifts in physicians’ demographic, cultural, and religious characteristics. PMID:20736675

Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs.

PubMed

Thalmann, O; Shapiro, B; Cui, P; Schuenemann, V J; Sawyer, S K; Greenfield, D L; Germonpré, M B; Sablin, M V; López-Giráldez, F; Domingo-Roura, X; Napierala, H; Uerpmann, H-P; Loponte, D M; Acosta, A A; Giemsch, L; Schmitz, R W; Worthington, B; Buikstra, J E; Druzhkova, A; Graphodatsky, A S; Ovodov, N D; Wahlberg, N; Freedman, A H; Schweizer, R M; Koepfli, K-P; Leonard, J A; Meyer, M; Krause, J; Pääbo, S; Green, R E; Wayne, R K

2013-11-15

The geographic and temporal origins of the domestic dog remain controversial, as genetic data suggest a domestication process in East Asia beginning 15,000 years ago, whereas the oldest doglike fossils are found in Europe and Siberia and date to >30,000 years ago. We analyzed the mitochondrial genomes of 18 prehistoric canids from Eurasia and the New World, along with a comprehensive panel of modern dogs and wolves. The mitochondrial genomes of all modern dogs are phylogenetically most closely related to either ancient or modern canids of Europe. Molecular dating suggests an onset of domestication there 18,800 to 32,100 years ago. These findings imply that domestic dogs are the culmination of a process that initiated with European hunter-gatherers and the canids with whom they interacted.

[3rd and 4th generation estroprogestatives French controversy: What effect on women's behavior?].

PubMed

Torres, Luis; Frapard, Christian; Daumas, Aurélie; Guibert, Nicolas; Lagouanelle-Simeoni, Marie-Claude; Rakoto, Jean-Claude; Villani, Patrick; Sambuc, Roland

2016-04-01

The primary objective of this study was to determine the reasons given by women who have changed or suspended their contraceptive method in 2013. What influence had the 3rd and 4th generation estroprogestatives (EP) French controversy and advices from doctors? Did they notice any consequences of the controversy on their lifestyle? Did they feel an impact on their behavior to health professionals? A study was conducted on women of childbearing age. Data collection took place between November 4 and December 16, 2013. The included subjects were between 18 and 55 years old females. Subjects were surveyed through an anonymous self-administered questionnaire distributed through pharmacies. The protocol called for the construction of clusters of subjects by having heard about, or not, of the controversy. Patients reporting having heard about the controversy have formed the "exposed" group while the others have formed the "unexposed" group. We compared two parameters between these two groups: the rate of subjects who reported having modified or suspended their contraceptive method in 2013 on one hand, and the rate of subjects who reported having made a change in their contraceptive method without or against advices from a doctor on the other hand. The sample included 988 subjects. The average age was 34 years. The level of exposure to media debates was 86.5%. Of the respondents, 19.8% were under 3rd or 4th generation EP in 2012, thus directly involved in the discussions and affected by health recommendations. Of the patients, 38.5% reported having changed their contraception in 2013. In these women, when they confirmed having heard about the controversy, 40.1% of them claimed to have conducted this process without or against advices from a doctor. This number dropped to 18.2% for those who had not heard of it. Media coverage of the 3rd and 4th generation EP vascular risk was not mentioned more by patients who suspended all medical contraceptive method than it was by

How did the fracking controversy emerge in the period 2010-2012?

PubMed

Mazur, Allan

2016-02-01

In 2010-2012, the controversy over fracking grew rapidly, first in the United States, and then internationally. An important step was the anti-fracking documentary film Gasland. With help from celebrity sources, the film was produced and won a prize at the Sundance Film Festival by early 2010 and had an Oscar nomination by early 2011, in the meantime popularizing potent images of hazard including tainted aquifers and ignitable water running from kitchen faucets. During this period, major US news organizations paid little attention to the issue. The offshore Deepwater Horizon disaster of April 2010 spurred The New York Times to prolific reporting on potential risks of the new onshore technique for extracting shale gas. With flagship news coverage, the controversy had by 2012 gained wide media attention that evoked public concern and opposition, spreading from the United States to other nations. © The Author(s) 2014.

Resolving Controversies Concerning the Kinetic Structure of Multi-Ion Plasma Shocks

NASA Astrophysics Data System (ADS)

Keenan, Brett; Simakov, Andrei; Chacon, Luis; Taitano, William

2017-10-01

Strong collisional shocks in multi-ion plasmas are featured in several high-energy-density environments, including Inertial Confinement Fusion (ICF) implosions. Yet, basic structural features of these shocks remain poorly understood (e.g., the shock width's dependence on the Mach number and the plasma ion composition, and temperature decoupling between ion species), causing controversies in the literature; even for stationary shocks in planar geometry [cf., Ref. and Ref.]. Using a LANL-developed, high-fidelity, 1D-2V Vlasov-Fokker-Planck code (iFP), as well as direct comparisons to multi-ion hydrodynamic simulations and semi-analytic predictions, we critically examine steady-state, planar shocks in two-ion species plasmas and put forward resolutions to these controversies. This work was supported by the Los Alamos National Laboratory LDRD Program, Metropolis Postdoctoral Fellowship for W.T.T., and used resources provided by the Los Alamos National Laboratory Institutional Computing Program.

Environmental Sensitive Areas (ESAs) changes in the Canyoles river watershed in Eastern Spain since the European Common Agriculture Policies (CAP) implementation

NASA Astrophysics Data System (ADS)

Ángel González Peñaloza, Félix; Cerdà, Artemi

2014-05-01

The Enviromental Sensitive Areas (ESAs) approach to study the Land Degradation is a methodology developed by professor Costas Kosmas et al., (1999) to map environmental sensitive areas and then the impact of Land Degradation and desertification on Mediterranean Type Ecosystems (Salvati et al., 2013). This methodology has been applied mainly to the Mediterranean Belt (Lavado Contador et al., 2009), but other authors adapted the methodology to other climatic regions (Izzo et al., 2013). The ESAs methodology allows mapping changes in the distribution of the sensitive areas to Desertification as a consequence of biophysical or human chances. In the Mediterranean countries of Europe, especially Spain, suffered a dramatic change due to the application of the European Common Agricultural Policies (CAP) after 1992. The objective of the CAP was to implemented policies to improve the environmental conditions of agricultural land. This target is especially relevant in Mediterranean areas of Spain, mainly the South and the East of the country. An Environmental Sensitive Area (ESAs) model (Kosmas et al., 2009) was implemented using Geographical Information System (GIS) tools, to identify, assess, monitor and map the levels of sensitivity to land degradation in the Canyoles river watershed, which is a representative landscape of the Mediterranean belt in Eastern Spain The results show that it was found that after the implementation of CAP, the most sensitive areas have expanded. This increase in degraded areas is driven by the expansion of commercial and chemically managed crops that increased the soil erosion (Cerdà et al., 2009) and that few soil conservation strategies were applied (Giménez Morera et al., 2010). Another factor that triggered Desertification processes is the increase in the recurrencesof forest fires as a consequence of land abandonment (Cerdà and Lasanta, 2005; Cerdà and Doerr, 2007). This contributed to an increase of scrubland. Our research show an

Six controversial issues on subclinical Cushing's syndrome.

PubMed

Chiodini, Iacopo; Albani, Adriana; Ambrogio, Alberto Giacinto; Campo, Michela; De Martino, Maria Cristina; Marcelli, Giorgia; Morelli, Valentina; Zampetti, Benedetta; Colao, Annamaria; Pivonello, Rosario

2017-05-01

Subclinical Cushing's syndrome is a condition of hypercortisolism in the absence of signs specific of overt cortisol excess, and it is associated with an increased risk of diabetes, hypertension, fragility fractures, cardiovascular events and mortality. The subclinical Cushing's syndrome is not rare, being estimated to be between 0.2-2 % in the adult population. Despite the huge number of studies that have been published in the recent years, several issues remain controversial for the subclinical Cushing's syndrome screening, diagnosis and treatment. The Altogether to Beat Cushing's syndrome Group was founded in 2012 for bringing together the leading Italian experts in the hypercortisolism-related diseases. This document represents the Altogether to Beat Cushing's syndrome viewpoint regarding the following controversial issues on Subclinical Cushing's syndrome (SCS): (1) Who has to be screened for subclinical Cushing's syndrome? (2) How to screen the populations at risk? (3) How to diagnose subclinical Cushing's syndrome in patients with an adrenal incidentaloma? (4) Which consequence of subclinical Cushing's syndrome has to be searched for? (5) How to address the therapy of choice in AI patients with subclinical Cushing's syndrome? (6) How to follow-up adrenal incidentaloma patients with subclinical Cushing's syndrome surgically or conservatively treated? Notwithstanding the fact that most studies that faced these points may have several biases (e.g., retrospective design, small sample size, different criteria for the subclinical Cushing's syndrome diagnosis), we believe that the literature evidence is sufficient to affirm that the subclinical Cushing's syndrome condition is not harmless and that the currently available diagnostic tools are reliable for identifying the majority of individuals with subclinical Cushing's syndrome.

The trans-Alaska pipeline controversy: Technology, conservation, and the frontier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coates, P.A.

1991-01-01

The Trans-Alaska Pipeline was the object of perhaps the most passionately fought conservation battle in the U.S. Although numerous authors documented the pipeline construction during its construction, there is, surprisingly, no previous scholarly treatment of this event written by an historian. Coates is an environmental historian who views the most interesting aspect of the controversy to be [open quote]its relationship to earlier engineering projects and technological innovations in Alaska and the debates that accompanied them.[close quotes] Thus, he describes how the conservationist and environmental ideas arose during numerous earlier major Alaskan projects and controversies, including the Alaska Highway (1938-41), Canolmore » Pipeline (1943-45), exploration of Naval Petroleum Reserve Number Four (Pet 4, 1944-1953), DEWline (1953-57), oil development in the Kenai National Moose Range (1957-58), statehood (1958), the creation of the Arctic Wildlife Refuge (1960), Project Chariot (1958-63), and Rampart Dam (1959-67). The history starts with the acquisition of Alaska in 1867 and finishes about the time of the Valdez oil spill in 1989.« less

Emerging therapies for hemophilia: controversies and unanswered questions

PubMed Central

Arruda, Valder R.; Doshi, Bhavya S.; Samelson-Jones, Benjamin J.

2018-01-01

Several new therapies for hemophilia have emerged in recent years. These strategies range from extended half-life factor replacement products and non-factor options with improved pharmacokinetic profiles to gene therapy aiming for phenotypic cure. While these products have the potential to change hemophilia care dramatically, several challenges and questions remain regarding broader applicability, long-term safety, and which option to pursue for each patient. Here, we review these emerging therapies with a focus on controversies and unanswered questions in each category. PMID:29770199

Determining Extension's Role in Controversial Issues: Content, Process, Neither, or Both?

ERIC Educational Resources Information Center

Goerlich, Dan; Walker, Martha A.

2015-01-01

Controversial issues offer Extension faculty opportunities to facilitate community dialogue and apply conflict resolution strategies to help communities achieve higher ground. Handled appropriately, the long-term benefits to the community, the Extension organization, and the faculty member of facilitating public issues outweigh the costs. This…

Race and Genetics: Controversies in Biomedical, Behavioral, and Forensic Sciences

ERIC Educational Resources Information Center

Ossorio, Pilar; Duster, Troy

2005-01-01

Among biomedical scientists, there is a great deal of controversy over the nature of race, the relevance of racial categories for research, and the proper methods of using racial variables. This article argues that researchers and scholars should avoid a binary-type argument, in which the question is whether to use race always or never.…

Reading "Daddy's Roommate": Preservice Teachers Respond to a Controversial Text.

ERIC Educational Resources Information Center

Williams, Shawyn

2002-01-01

Explores the responses of the author's 31 pre-service teachers to a controversial picture book. Begins by searching for a short text geared to elementary age children and suited for read-alouds. Notes that she believes that the majority of pre-service teachers at this stage in the program are still very impressionable and must be given multiple…

A Review and Update of Treatment Options and Controversies in the Management of Hepatocellular Carcinoma.

PubMed

Dhir, Mashaal; Melin, Alyson A; Douaiher, Jeffrey; Lin, Chi; Zhen, Weining Ken; Hussain, Shahid M; Geschwind, Jean-Francois H; Doyle, Maria B Majella; Abou-Alfa, Ghassan K; Are, Chandrakanth

2016-06-01

To review the current management, outline recent advances and address controversies in the management of hepatocellular carcinoma (HCC). The treatment of HCC is multidisciplinary involving hepatologists, surgeons, medical oncologists, radiation oncologists, radiologists, interventional radiologists, and other disciplines. Each of these disciplines brings its unique perspective and differing opinions that add to controversies in the management of HCC. A focused literature review was performed to identify recent studies on the management of HCC and thereby summarize relevant information on the various therapeutic modalities and controversies involved in the treatment of HCC. The main treatment algorithms continue to rely on hepatic resection or transplantation with controversies involving patients harboring early stage disease and borderline hepatic function. The other treatment strategies include locoregional therapies, radiation, and systemic therapy used alone or in combination with other treatment modalities. Recent advances in locoregional therapies, radiation, and systemic therapies have provided better therapeutic options with curative intent potential for some locoregional therapies. Further refinements in combination therapies such as algorithms consisting of locoregional therapies and systemic or radiation therapies are likely to add additional options and improve survival. The management of HCC has witnessed significant strides with advances in existing options and introduction of several new treatment modalities of various combinations. Further refinements in these treatment options combined with enrollment in clinical trials are essential to improve the management and outcomes of patients with HCC.

Controversies in breast cancer: adjuvant and neoadjuvant therapy.

PubMed

Montemurro, Filippo; Redana, Stefania; Valabrega, Giorgio; Aglietta, Massimo

2005-06-01

Initial randomised studies of chemotherapy and endocrine therapy showed that systemic treatments had a substantial impact on the survival of women with early breast cancer. The original assumption was that the efficacy of these treatments was limited to those patients presenting with more adverse prognostic features. Subsequently, meta-analyses of randomised trials revealed that the benefits of chemotherapy and endocrine therapy are not mutually exclusive and extend to all the prognostic subgroups. However, the absolute benefit varies according to baseline characteristics such as tumour stage and other biological factors. Over the last 10 years, considerable progress has been made with the introduction of new drugs into the adjuvant and neoadjuvant treatment of women with breast cancer. Taxanes and third-generation aromatase inhibitors are providing proof of additional benefits compared with standard reference treatments. In parallel, research on the biology of breast cancer is establishing novel prognostic and predictive factors, which may allow better treatment tailoring. Currently, however, women with early breast cancer and their doctors face the difficult task of making therapeutic decisions often based on early results from positive studies. In a disease where follow up is crucial to fully assess the benefit and long-term toxicities of an intervention, current knowledge leaves unanswered questions that generate debate and controversy. This review will summarise recent results from randomised trials of adjuvant and neoadjuvant therapy in women with early breast cancer and focus on the current controversies.

Controversies relating to the management of acromioclavicular joint dislocations.

PubMed

Modi, C S; Beazley, J; Zywiel, M G; Lawrence, T M; Veillette, C J H

2013-12-01

The aim of this review is to address controversies in the management of dislocations of the acromioclavicular joint. Current evidence suggests that operative rather than non-operative treatment of Rockwood grade III dislocations results in better cosmetic and radiological results, similar functional outcomes and longer time off work. Early surgery results in better functional and radiological outcomes with a reduced risk of infection and loss of reduction compared with delayed surgery. Surgical options include acromioclavicular fixation, coracoclavicular fixation and coracoclavicular ligament reconstruction. Although non-controlled studies report promising results for arthroscopic coracoclavicular fixation, there are no comparative studies with open techniques to draw conclusions about the best surgical approach. Non-rigid coracoclavicular fixation with tendon graft or synthetic materials, or rigid acromioclavicular fixation with a hook plate, is preferable to fixation with coracoclavicular screws owing to significant risks of loosening and breakage. The evidence, although limited, also suggests that anatomical ligament reconstruction with autograft or certain synthetic grafts may have better outcomes than non-anatomical transfer of the coracoacromial ligament. It has been suggested that this is due to better restoration horizontal and vertical stability of the joint. Despite the large number of recently published studies, there remains a lack of high-quality evidence, making it difficult to draw firm conclusions regarding these controversial issues.

Diagnostic performance of HbA1c for diabetes in Arab vs. European populations: a systematic review and meta-analysis.

PubMed

Bertran, E A; Berlie, H D; Taylor, A; Divine, G; Jaber, L A

2017-02-01

To examine differences in the performance of HbA 1c for diagnosing diabetes in Arabs compared with Europeans. The PubMed, Embase and Cochrane library databases were searched for records published between 1998 and 2015. Estimates of sensitivity, specificity and log diagnostic odds ratios for an HbA 1c cut-point of 48 mmol/mol (6.5%) were compared between Arabs and Europeans, using a bivariate linear mixed-model approach. For studies reporting multiple cut-points, population-specific summary receiver operating characteristic (SROC) curves were constructed. In addition, sensitivity, specificity and Youden Index were estimated for strata defined by HbA 1c cut-point and population type. Database searches yielded 1912 unique records; 618 full-text articles were reviewed. Fourteen studies met the inclusion criteria; hand-searching yielded three additional eligible studies. Three Arab (N = 2880) and 16 European populations (N = 49 127) were included in the analysis. Summary sensitivity and specificity for a HbA 1c cut-point of 48 mmol/mol (6.5%) in both populations were 42% (33-51%), and 97% (95-98%). There was no difference in area under SROC curves between Arab and European populations (0.844 vs. 0.847; P = 0.867), suggesting no difference in HbA 1c diagnostic accuracy between populations. Multiple cut-point summary estimates stratified by population suggest that Arabs have lower sensitivity and higher specificity at a HbA 1c cut-point of 44 mmol/mol (6.2%) compared with European populations. Estimates also suggest similar test performance at cut-points of 44 mmol/mol (6.2%) and 48 mmol/mol (6.5%) for Arabs. Given the low sensitivity of HbA 1c in the high-risk Arab American population, we recommend a combination of glucose-based and HbA 1c testing to ensure an accurate and timely diagnosis of diabetes. © 2016 Diabetes UK.

The letter: private text or public place? The Mattioli-Gesner controversy about the aconitum primum.

PubMed

Delisle, Candice

2004-01-01

From 1555 to 1565, Pietro Andrea Mattioli and Conrad Gesner were locked in controversy over the veracity of Mattioli's picture of aconitum primum. This dispute led to numerous vehement publications and to intensive exchanges of letters, not only between the protagonists but also within their own and sometimes inter-connected networks of correspondence. This dispute illustrates how 16th-century scholars played upon the ambiguous place of these letters between private and public space to deal with controversy in the Republic of Letters.

Beyond Controversies: Sexuality Education for Adolescents in India

PubMed Central

Khubchandani, Jagdish; Clark, Jeffrey; Kumar, Raman

2014-01-01

Sexuality education for adolescents is one of the most controversial topics in the field of child health. In the past decade, policymakers in India have also struggled with the issue and there has been greater public discourse. However, policymaking and public discussions on adolescent sexuality education are frequently fueled by religious, social, and cultural values, while receiving scant scientific attention. To meet the needs of an expanding young population in India, scientific evidence for best practices must be kept at the core of policymaking in the context of sexuality education for adolescents. PMID:25374847

Integrating Research and Practice: Distractions, Controversies, and Options for Moving Forward

ERIC Educational Resources Information Center

Gambrill, Eileen

2015-01-01

Integrating practice and research is vital in all helping professions in order to offer the most ethical, evidence-informed interventions to clients. This article describes some avoidable distractions that hinder integration, discusses controversies related to integration, and describes options for moving forward, including making wasted resources…

The effect of land use intensity on soil organic carbon stocks of European croplands

NASA Astrophysics Data System (ADS)

Dechow, Rene; Gebbert, Sören; Franko, Uwe; Kätterer, Thomas; Kolbe, Hartmut

2013-04-01

Croplands cover about one third of Europe and are assumed to be the biggest source of greenhouse gas emissions of the European biosphere with the degradation of soil organic carbon (SOC) being a major contributor of this source. Soil carbon stocks of croplands are subjected to ranges of natural and anthropogenic influences that control the release or uptake of CO2. The separation of drivers is essential for assessing recent and prospective GHG mitigation potentials by cropland management. Within the last decades the management of European croplands is characterized by an ongoing intensification. The increasing influence of the global market on farmers' decision and the establishment of industrialized farming practise in Europe had significant impact on the shift of crop rotations during the last decades. Due to the high spatial variability and the dominating fraction of slowly degradable carbon it needs at least decades to detect changes while agricultural management is characterized by short term system interventions. Long term observations representing time intervals of decades to hundreds of years are therefore essential to make reliable suggestions about the sensitivity of soil carbon turnover against external impacts because the temporal scale of these experiments corresponds to the temporal scale of soil C turnover. A data set of about 32 European long-term experiments (380 variants) was used to quantify the uncertainty of the RothC soil carbon model. The parameters of the model were adapted to represent the sensitivity of SOC on weather conditions and crop types found in the data set by applying an Monte Carlo Markov Chain algorithm. Integrated in a GIS environment the modified model was used to run scenarios that vary in terms of climate conditions and crop rotations within the time period 1970-2010 on a European scale. Regionalized sensitivities of SOC on natural drivers and crop rotations will be presented.

The Effect of Falsely Balanced Reporting of the Autism-Vaccine Controversy on Vaccine Safety Perceptions and Behavioral Intentions

ERIC Educational Resources Information Center

Dixon, Graham; Clarke, Christopher

2013-01-01

Controversy surrounding an autism-vaccine link has elicited considerable news media attention. Despite being widely discredited, research suggests that journalists report this controversy by presenting claims both for and against a link in a relatively "balanced" fashion. To investigate how this reporting style influences judgments of vaccine…

Adult Attachment States of Mind: Measurement Invariance across Ethnicity and Associations with Maternal Sensitivity

PubMed Central

Haltigan, John D.; Leerkes, Esther M.; Wong, Maria S.; Fortuna, Keren; Roisman, Glenn I.; Supple, Andrew J.; O’Brien, Marion; Calkins, Susan D.; Plamondon, André

2017-01-01

The current study examined the developmental significance of mothers’ adult attachment representations assessed prenatally with the Adult Attachment Interview in relation to observed maternal sensitivity at 6 months postpartum in an ethnically diverse sample (N = 131 African American; N = 128 European American). Multiple groups confirmatory factor analyses provided evidence for partial measurement invariance of a two factor dismissing and preoccupied latent structure of adult attachment across the two ethnic groups of women. African American women showed modest elevations on the preoccupied factor relative to European American women. Although the dismissing factor showed an empirically equivalent negative association with maternal sensitivity in both ethnic groups, this effect was reduced to marginal significance when controlling for maternal socioeconomic status. PMID:24936609

Cholangiocarcinoma—controversies and challenges

PubMed Central

Patel, Tushar

2013-01-01

Cholangiocarcinomas are a diverse group of tumors that are presumed to originate from the biliary tract epithelium either within the liver or the biliary tract. These cancers are often difficult to diagnose, their pathogenesis is poorly understood, and their dismal prognosis has resulted in a nihilistic approach to their management. The two major clinical phenotypes are intrahepatic, mass-forming tumors and large ductal tumors. Among the ductal cancers, lesions at the liver hilum are most prevalent. The risk factors, clinical presentation, natural history and management of these two types of cholangiocarcinoma are distinct. Efforts to improve outcomes for patients with these diseases are affected by several challenges to effective management. For example, designations based on anatomical characteristics have been inconsistently applied, which has confounded analysis of epidemiological trends and assessment of risk factors. The evaluation of therapeutic options, particularly systemic therapies, has been limited by a lack of appreciation of the different phenotypes. Controversies exist regarding the appropriate workup and choice of management approach. However, new and emerging tools for improved diagnosis, expanded indications for surgical approaches, an emerging role for locoregional and intrabiliary therapies and improved systemic therapies provide optimism and hope for improved outcomes in the future. PMID:21460876

Race and Intelligence: The Fallacies Behind the Race-IQ Controversy.

ERIC Educational Resources Information Center

Richardson, Ken, Ed.; Spears, David, Ed.

This collection of essays about intelligence stems from the revived nature-nurture controversy about the origins of mental abilities, led notably by Arthur Jensen, whose article in 1969 created a furore in the U.S.A., and more lately by H. J. Eysenck in Britain. In planning this book, an attempt has been made to step back from the debate itself…

42 CFR 405.740 - Principles for determining the amount in controversy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Principles for determining the amount in... Reconsiderations and Appeals Under Medicare Part A § 405.740 Principles for determining the amount in controversy... more appellants, the Secretary may assert that the aggregation principles contained in this subpart may...

The Columbus Controversy: A Historian Walks through the Battlefield of Ideas.

ERIC Educational Resources Information Center

Thernstrom, Stephan

1992-01-01

Reviews controversies concerning celebrating the 500th anniversary of Columbus' landing in America. Summarizes historians' perspectives concerning that event, including the following: (1) who was first; (2) discovery or invasion; (3) native population numbers; (4) how so few conquered so many; (5) Columbus and slavery; and (6) Columbus and…

Non Celiac Gluten Sensitivity.

PubMed

Bardella, Maria Teresa; Elli, Luca; Ferretti, Francesca

2016-12-01

A new syndrome responding to gluten-free diet and defined non-celiac gluten sensitivity entered the spectrum of gluten-related disorders, together with celiac disease and wheat allergy. However, its definition, prevalence, diagnosis, pathogenesis, treatment, and follow up are still controversial. The purpose of the review is to summarize the evidence and problems emerging from the current literature. Direct implication of gluten in the onset of symptoms is often unproved as a low fermentable oligo-, di- and mono-saccharides and polyols diet or other components of cereals as wheat amylase trypsin inhibitor could be similarly involved. To date, no specific biomarkers or histological abnormalities confirm diagnosis, and only the self-reported response to gluten-free diet as well as a positive double blind placebo-gluten challenge characterizes these non-celiac, non-wheat allergic patients. Critical revision of published studies can offer practical indications in approaching this clinical topic and useful suggestions to standardize scientific researches.

Behavioral consequences of conflict-oriented health news coverage: the 2009 mammography guideline controversy and online information seeking.

PubMed

Weeks, Brian E; Friedenberg, Laura M; Southwell, Brian G; Slater, Jonathan S

2012-01-01

Building on channel complementarity theory and media-system dependency theory, this study explores the impact of conflict-oriented news coverage of health issues on information seeking online. Using Google search data as a measure of behavior, we demonstrate that controversial news coverage of the U.S. Preventive Services Task Force's November 2009 recommendations for changes in breast cancer screening guidelines strongly predicted the volume of same-day online searches for information about mammograms. We also found that this relationship did not exist 1 year prior to the coverage, during which mammography news coverage did not focus on the guideline controversy, suggesting that the controversy frame may have driven search behavior. We discuss the implications of these results for health communication scholars and practitioners.

The Oil Drop Experiment: A Rational Reconstruction of the Millikan-Ehrenhaft Controversy and Its Implications for Chemistry Textbooks.

ERIC Educational Resources Information Center

Niaz, Mansoor

2000-01-01

Develops a history and philosophy of science framework based on a rational reconstruction of experimental observations that led to the Millikan-Ehrenhaft controversy, and evaluates 31 chemistry books for coverage of the controversy. Finds that most books lacked a history and philosophy of science perspective and did not adequately address several…

Using a Historical Controversy to Teach Critical Thinking, the Meaning of "Theory", and the Status of Scientific Knowledge

ERIC Educational Resources Information Center

Montgomery, Keith

2009-01-01

It is important that students understand the "open-ended" nature of scientific knowledge and the correct relationship between facts and theory. One way this can be taught is to examine a past controversy in which the interpretation of facts was contested. The controversy discussed here, with suggestions for teaching, is "Expanding…

The Breivik controversy: politics, terrorism and psychiatry.

PubMed

Tietze, Tad

2014-08-01

To examine and analyse the controversy over psychiatric aspects of the case of Norwegian far right mass murderer Anders Behring Breivik. Because of a basic acceptance of methodological individualism and scientific positivism, mainstream psychiatry is currently ill suited to being broadly applied to the spheres of politics and political violence. Rather than jettison psychiatric insights in such cases, the choices facing the profession are either to accept the narrowness of its utility or to work towards a theoretical framework that sees the individual psyche as socially embedded rather than as socially constitutive, and psychiatric science itself as socially constructed and hence inescapably value-laden. © The Royal Australian and New Zealand College of Psychiatrists 2014.

Management of endometrial cancer: issues and controversies.

PubMed

Bogani, G; Dowdy, S C; Cliby, W A; Ghezzi, F; Rossetti, D; Frigerio, L; Mariani, A

2016-01-01

Although endometrial cancer (EC) is the most common gynecologic cancer in developed countries, several aspects of its management are still controversial. In particular, the need to perform lymphadenectomy represents an important matter of discussion. Because of the discordant results in the literature, it is still not possible to draft any definitive conclusions regarding the therapeutic value of lymph node dissection. The present review discusses the role of lymphadenectomy in the setting of EC, risk factors for lymphatic spread, identification of patients at risk for lymph node dissemination, and the current evidence for adjuvant therapies in patients with positive nodes. Reasons for the difficulty in demonstrating any therapeutic value of pelvic and para-aortic lymphadenectomy are also discussed.

Drug safety: Pregnancy rating classifications and controversies.

PubMed

Wilmer, Erin; Chai, Sandy; Kroumpouzos, George

2016-01-01

This contribution consolidates data on international pregnancy rating classifications, including the former US Food and Drug Administration (FDA), Swedish, and Australian classification systems, as well as the evidence-based medicine system, and discusses discrepancies among them. It reviews the new Pregnancy and Lactation Labeling Rule (PLLR) that replaced the former FDA labeling system with narrative-based labeling requirements. PLLR emphasizes on human data and highlights pregnancy exposure registry information. In this context, the review discusses important data on the safety of most medications used in the management of skin disease in pregnancy. There are also discussions of controversies relevant to the safety of certain dermatologic medications during gestation. Copyright © 2016 Elsevier Inc. All rights reserved.

The dental amalgam controversy: a review

PubMed Central

Feuer, George; Injeyan, H Stephen

1996-01-01

In spite of the long history of mercury amalgam as a dental restorative material, its use continues to be controversial. Mercury vapour is continuously released from dental amalgam and is ultimately absorbed into a variety of tissues. Experimental data have demonstrated that the uptake, tissue retention and excretion of mercury from dental amalgam is significant. Evidence has accumulated indicating a relationship between tissue mercury levels and a multitude of clinical manifestations. However, the clinical significance of mercury toxicity from dental amalgams is a matter for debate. The literature is devoid of randomized clinical trials that are rigorously designed to address this issue. Thus, although research data renders the notion of amalgam safety questionable, the dental community appears determined to continue its use as long as unequivocal evidence correlating amalgam mercury toxicity to specific clinical conditions is lacking.

Revisiting the left-wing response to sociobiology: the case of Finland in a European context.

PubMed

Lepistö, Antti

2015-01-01

This article revisits the left-wing response to sociobiology in the 1970s and 1980s by examining the sociobiology debate in Finland in a larger European context. It argues that the Finnish academic left's response to sociobiology represents a "third way" alongside the purely negative, often Marxist denial of biology's relevance, which characterized the left's response to sociobiology in many European countries such as Hungary and Sweden, and alongside the disregard that sociobiology confronted in most parts of Eastern Europe, as well as in Germany. In the context of the last great political conflict of the Cold War in Europe, the controversy over the American "Euromissiles" (Pershing II and Tomahawk) in 1979-1983, the Finnish academic left challenged the allegedly fatalistic sociobiological aggression and war theories with an alternative biological language, turning the increasing enthusiasm over evolutionary ideas into a pacifist cause. Using leftist and pacifist forums to inform citizens and politicians of such biologically evolved human characteristics as mutual care and sociability, the Finnish critics of sociobiology wished to boost the public spirit, and to rationalize the pacifist ideal of the European-wide popular movement against nuclear weapons and militarism. As a result, the academic leftists in Finland revived the early twentieth-century tradition of "peace biology." A proper understanding of this development calls for an analysis that acknowledges Finland's special geopolitical and cultural position in the Cold War world between East and West.

Differences in Allergic Sensitization by Self-reported Race and Genetic Ancestry

PubMed Central

Yang, James J.; Burchard, Esteban G.; Choudhry, Shweta; Johnson, Christine C.; Ownby, Dennis R.; Favro, David; Chen, Justin; Akana, Matthew; Ha, Connie; Kwok, Pui-Yan; Krajenta, Richard; Havstad, Suzanne L.; Joseph, Christine L.; Seibold, Max A.; Shriver, Mark D.; Williams, L. Keoki

2010-01-01

Background Many allergic conditions occur more frequently in African-American patients when compared with white patients; however it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective To assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods We included 601 women enrolled in a population-based cohort study whose self-reported race was African-American or white. Genetic ancestry was estimated using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE result) and both self-reported race and genetic ancestry. Regression models adjusted for socio-demographic variables, environmental exposures, and location of residence. Results The average proportion of West African ancestry in African-American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African-American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio [aOR] 2.19; 95% confidence interval [CI] 1.22 – 3.93) even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (aOR 2.09 for urban vs. suburban residence, 95% CI 1.32 −3.31). Conclusion Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race may be primarily due to environmental factors rather than genetic differences. Clinical Implications These data suggest that efforts to eliminate disparities in allergic sensitization should focus on contributing environmental factors. PMID:19014772

Making Citizens, Being European? European Symbolism in Slovenian Citizenship Education Textbooks

ERIC Educational Resources Information Center

Banjac, Marinko; Pušnik, Tomaž

2015-01-01

Citizenship education has been an important part of the European Union's (EU) agenda to integrate a European dimension into schools' curricula. The usage of European symbolism in citizenship education curriculum material has been an especially important (yet understudied) means not only to promote a distinct European identity and increase…

General Education Today. A Critical Analysis of Controversies, Practices, and Reforms.

ERIC Educational Resources Information Center

Gaff, Jerry G.

The range of controversies and changes emerging from the current revival of general education are examined, and many ideas, examples, and recommendations for achieving realistic and successful curricular reform are offered. Instead of either offering an apology for general education or advocating any particular approach, the book draws on solid…

Prediction of Students' Argumentation Skills about Controversial Topics by Epistemological Understanding

ERIC Educational Resources Information Center

Mason, Lucia; Scirica, Fabio

2006-01-01

This study focuses on the contribution of overall epistemological understanding to argumentation skills, after controlling for topic knowledge and interest, in eighth graders. Students were introduced to two controversial topics, global warming and genetically modified food, through the reading of a two-sided text on each topic. After reading,…

Clinical Correlates of Alleged Satanic Abuse and Less Controversial Sexual Molestation.

ERIC Educational Resources Information Center

Leavitt, Frank

1994-01-01

This study found that 39 women alleging satanic ritual abuse and 47 women reporting less controversial forms of sexual trauma as children were characterized by high but nondiscriminating levels of psychiatric pathology. Patients alleging satanic ritual abuse reported higher levels of dissociation, in the range often exhibited by patients with…

"...Not Simply Say That They Are All Nazis." Controversy in Discussions of Current Topics in German Civics Classes

ERIC Educational Resources Information Center

Jahr, David; Hempel, Christopher; Heinz, Marcus

2016-01-01

Studies have shown that the Requirement of Controversy defined in the German Beutelsbach Consensus is repeatedly violated in the practice of teaching Civic Education. However, little is known about the impact that different teaching settings have on the quality of controversy in the classroom. In this article, two scenes of classroom discussions…

The Offshore New European Wind Atlas

NASA Astrophysics Data System (ADS)

Karagali, I.; Hahmann, A. N.; Badger, M.; Hasager, C.; Mann, J.

2017-12-01

The New European Wind Atlas (NEWA) is a joint effort of research agencies from eight European countries, co-funded under the ERANET Plus Program. The project is structured around two areas of work: development of dynamical downscaling methodologies and measurement campaigns to validate these methodologies, leading to the creation and publication of a European wind atlas in electronic form. This atlas will contain an offshore component extending 100 km from the European coasts. To achieve this, mesoscale models along with various observational datasets are utilised. Scanning lidars located at the coastline were used to compare the coastal wind gradient reproduced by the meso-scale model. Currently, an experimental campaign is occurring in the Baltic Sea, with a lidar located in a commercial ship sailing from Germany to Lithuania, thus covering the entire span of the south Baltic basin. In addition, satellite wind retrievals from scatterometers and Synthetic Aperture Radar (SAR) instruments were used to generate mean wind field maps and validate offshore modelled wind fields and identify the optimal model set-up parameters.The aim of this study is to compare the initial outputs from the offshore wind atlas produced by the Weather & Research Forecasting (WRF) model, still in pre-operational phase, and the METOP-A/B Advanced Scatterometer (ASCAT) wind fields, reprocessed to stress equivalent winds at 10m. Different experiments were set-up to evaluate the model sensitivity for the various domains covered by the NEWA offshore atlas. ASCAT winds were utilised to assess the performance of the WRF offshore atlases. In addition, ASCAT winds were used to create an offshore atlas covering the years 2007 to 2016, capturing the signature of various spatial wind features, such as channelling and lee effects from complex coastal topographical elements.

Representing New Math: Genre Chains and Controversy in the Saskatchewan Media

ERIC Educational Resources Information Center

LeBlanc, Robert J.

2012-01-01

The media's response to the release of "Math Instruction that Makes Sense" (2011), a research report by the Frontier Centre for Public Policy (FCPP), helped spark a public controversy and spur the Saskatchewan government to reexamine the Ministry of Education's math curriculum. The purpose of this article is to examine the CBC's…

An Evolving Controversy: The Struggle to Teach Science in Science Classes

ERIC Educational Resources Information Center

Berkman, Michael; Plutzer, Eric

2012-01-01

Although the level of controversy varies from one community to the next, biology teachers across the United States struggle to teach evolution. Some face pressure to teach both religious and scientific theories of human origins; others did not have adequate coursework on evolution during teacher preparation. As a result, many biology teachers are…

Service and Emotional Support Animals on Campus: The Relevance and Controversy

ERIC Educational Resources Information Center

Phillips, Melinda

2016-01-01

Service and emotional support animals (ESA) have recently been a topic of conversation on college campuses, despite decades of controversy related to the interpretation of federal law. The distinction between an Emotional Support Animal and Service Animals, and the rights of the student regarding accommodations under FHA and ADA have been debated…

Controversies in "clearing" trauma to the cervical spine.

PubMed

Tins, Bernhard; Cassar-Pullicino, Victor

2007-04-01

Clearance of the traumatic cervical spine is a subject affecting most healthcare professionals dealing with trauma patients. There is a host of often contradictory literature making it hard for an interested reader to come to their own informed opinion based on the current evidence. This review aims to outline the relevant literature for the clearance of the traumatic cervical spine with the particular aim of highlighting the contradictions, controversies and unanswered questions still besetting this important subject. A brief, subjective opinion for a combined clinical and imaging protocol for clearance of the traumatic cervical spine is given.

Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union.

PubMed

Bellanger, Martine; Demeneix, Barbara; Grandjean, Philippe; Zoeller, R Thomas; Trasande, Leonardo

2015-04-01

Epidemiological studies and animal models demonstrate that endocrine-disrupting chemicals (EDCs) contribute to cognitive deficits and neurodevelopmental disabilities. The objective was to estimate neurodevelopmental disability and associated costs that can be reasonably attributed to EDC exposure in the European Union. An expert panel applied a weight-of-evidence characterization adapted from the Intergovernmental Panel on Climate Change. Exposure-response relationships and reference levels were evaluated for relevant EDCs, and biomarker data were organized from peer-reviewed studies to represent European exposure and approximate burden of disease. Cost estimation as of 2010 utilized lifetime economic productivity estimates, lifetime cost estimates for autism spectrum disorder, and annual costs for attention-deficit hyperactivity disorder. Setting, Patients and Participants, and Intervention: Cost estimation was carried out from a societal perspective, ie, including direct costs (eg, treatment costs) and indirect costs such as productivity loss. The panel identified a 70-100% probability that polybrominated diphenyl ether and organophosphate exposures contribute to IQ loss in the European population. Polybrominated diphenyl ether exposures were associated with 873,000 (sensitivity analysis, 148,000 to 2.02 million) lost IQ points and 3290 (sensitivity analysis, 3290 to 8080) cases of intellectual disability, at costs of €9.59 billion (sensitivity analysis, €1.58 billion to €22.4 billion). Organophosphate exposures were associated with 13.0 million (sensitivity analysis, 4.24 million to 17.1 million) lost IQ points and 59 300 (sensitivity analysis, 16,500 to 84,400) cases of intellectual disability, at costs of €146 billion (sensitivity analysis, €46.8 billion to €194 billion). Autism spectrum disorder causation by multiple EDCs was assigned a 20-39% probability, with 316 (sensitivity analysis, 126-631) attributable cases at a cost of €199 million

The European functional tree of bird life in the face of global change

PubMed Central

Thuiller, Wilfried; Pironon, Samuel; Psomas, Achilleas; Barbet-Massin, Morgane; Jiguet, Frédéric; Lavergne, Sébastien; Pearman, Peter B.; Renaud, Julien; Zupan, Laure; Zimmermann, Niklaus E.

2014-01-01

Despite the recognized joint impact of climate and land cover change on facets of biodiversity and their associated functions, risk assessments have primarily evaluated impacts on species ranges and richness. Here we quantify the sensitivity of the functional structure of European avian assemblages to changes in both regional climate and land cover. We combine species range forecasts with functional trait information. We show that species sensitivity to environmental change is randomly distributed across the functional tree of the European avifauna and that functionally unique species are not disproportionately threatened by 2080. However, projected species range changes will modify the mean species richness and functional diversity of bird diets and feeding behaviours. This will unequally affect the spatial structure of functional diversity, leading to homogenization across Europe. Therefore, global changes may alter the functional structure of species assemblages in the future in ways that need to be accounted for in conservation planning. PMID:24452245

European Multicenter Study on Analytical Performance of DxN Veris System HCV Assay.

PubMed

Braun, Patrick; Delgado, Rafael; Drago, Monica; Fanti, Diana; Fleury, Hervé; Gismondo, Maria Rita; Hofmann, Jörg; Izopet, Jacques; Kühn, Sebastian; Lombardi, Alessandra; Marcos, Maria Angeles; Sauné, Karine; O'Shea, Siobhan; Pérez-Rivilla, Alfredo; Ramble, John; Trimoulet, Pascale; Vila, Jordi; Whittaker, Duncan; Artus, Alain; Rhodes, Daniel W

2017-04-01

The analytical performance of the Veris HCV Assay for use on the new and fully automated Beckman Coulter DxN Veris Molecular Diagnostics System (DxN Veris System) was evaluated at 10 European virology laboratories. Precision, analytical sensitivity, specificity, and performance with negative samples, linearity, and performance with hepatitis C virus (HCV) genotypes were evaluated. Precision for all sites showed a standard deviation (SD) of 0.22 log 10 IU/ml or lower for each level tested. Analytical sensitivity determined by probit analysis was between 6.2 and 9.0 IU/ml. Specificity on 94 unique patient samples was 100%, and performance with 1,089 negative samples demonstrated 100% not-detected results. Linearity using patient samples was shown from 1.34 to 6.94 log 10 IU/ml. The assay demonstrated linearity upon dilution with all HCV genotypes. The Veris HCV Assay demonstrated an analytical performance comparable to that of currently marketed HCV assays when tested across multiple European sites. Copyright © 2017 American Society for Microbiology.

Controversies in the Management of Endometrial Carcinoma: An Update

PubMed Central

Mehasseb, Mohamed K.; Latimer, John A.

2012-01-01

Endometrial carcinoma is the commonest type of female genital tract malignancy in the developed countries. Endometrial carcinoma is usually confined to the uterus at the time of diagnosis and as such usually carries an excellent prognosis with high curability. Our understanding and management of endometrial cancer have continuously developed. Current controversies focus on screening and early detection, the extent of nodal surgery, and the changing roles of radiation therapy and chemotherapy and will be discussed in this paper. PMID:22518164

Controversial endocrine interventions for the aged.

PubMed

Leow, M K S; Loh, K C

2006-07-01

Specific endocrine changes occur with the ageing process. The last decade has witnessed significant progress in the basic and clinical science of ageing, thereby rejuvenating the interest in anti-ageing medicine, especially that of hormone replacement, by medical professionals and the lay public. However, endocrine manipulation as a therapeutic strategy for ageing is still evolving as continuing research attempts to answer the many questions of what it can achieve at the risk of incurring unknown long-term adverse effects. The current day doctor is confronted with a host of options, and will benefit from a synopsis of the latest evidence before making the most appropriate decision for aged patients seeking hormonal replacement therapy as a means to counter the effects of ageing. This review aims to give a rapid overview of the endocrine profile of geriatric population and the studies on the more controversial hormonal replacement therapies for the aged.

Prevention of sudden cardiac death in young athletes: controversies and conundrums.

PubMed

Rowland, Thomas

2011-01-01

Strategies for preventing sudden cardiac death in young athletes are predicated on the assumption that: (1) these events reflect pre-existing, clinically silent heart disease, and (2) means for detecting these abnormalities on the pre-participation evaluation are both feasible and accurate. Recent controversy has surrounded both of these presumptions. Some evidence suggests that the myocardial hypertrophy accompanying sports training itself might serve as a substrate for fatal arrhythmias. As well, vigorous debate has arisen over the optimal content of the pre-participation evaluation, particularly regarding the inclusion of routine screening electrocardiograms. As the rarity of these fatal events does not lend itself to an experimental approach, such disagreements are not easily resolved. Consequently, it is expected that decisions regarding approaches to prevention of sudden death in athletes will be dictated largely by region-specific financial, political, and cultural factors. This chapter examines the aetiologies of sudden cardiac death in young athletes as well as the controversies surrounding the prevention of these tragedies. Copyright © 2011 S. Karger AG, Basel.

Managing controversy through consultation: a qualitative study of communication and trust around MMR vaccination decisions

PubMed Central

McMurray, Robert; Cheater, Francine M; Weighall, Anna; Nelson, Carolyn; Schweiger, Martin; Mukherjee, Suzanne

2004-01-01

Background: Controversy over the measles, mumps, and rubella (MMR) vaccine has reduced uptake, raising concerns of a future disease epidemic. Aims: To explore parents' accounts of decision making relating to the MMR vaccine controversy, identifying uptake determinants and education needs. Design of study: Qualitative interviews analysed using the ‘framework’ approach. Setting: Five general practices in the Leeds area, 2002–2003. Method: Sixty-nine interviews conducted with parents of children aged between 4 and 5 years, and 12 interviews with primary care practitioners, managers and immunisation coordinators serving participating sites. Participants were interviewed one-to-one in a place of their choice. Results: The vaccination decision is primarily a function of parental assessments of the relative acceptability and likelihood of possible outcomes. For most parents the evidence of science and medicine plays little role in the decision. Although local general practitioners and health visitors are trusted information sources, the influence of primary care providers on the vaccination decision is limited by concerns over consultation legitimacy, discussion opportunity, and perceptions of financial and political partiality. Parents and practitioners identify a need for new approaches to support decisions and learning when faced with this and similar healthcare controversies. These include new collaborative approaches to information exchange designed to transform rather than supplant existing parent knowledge as part of an ongoing learning process. Conclusion: The study identified new ways in which parents and practitioners need to be supported in order to increase understanding of medical science and secure more informed decisions in the face of health controversy. PMID:15239914

Acute Kidney Injury: Diagnostic Approaches and Controversies

PubMed Central

Makris, Konstantinos; Spanou, Loukia

2016-01-01

Acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality. In the last ten years a large number of publications have highlighted the limitations of traditional approaches and the inadequacies of conventional biomarkers to diagnose and monitor renal insufficiency in the acute setting. A great effort was directed not only to the discovery and validation of new biomarkers aimed to detect AKI more accurately but also to standardise the definition of AKI. Despite the advances in both areas, biomarkers have not yet entered into routine clinical practice and the definition of this syndrome has many areas of uncertainty. This review will discuss the controversies in diagnosis and the potential of novel biomarkers to improve the definition of the syndrome. PMID:28167845

Diabetes mellitus and tuberculosis facts and controversies

PubMed Central

2013-01-01

Tuberculosis (TB) and diabetes mellitus (DM) are both important health issues. A bidirectional association between them has been demonstrated by many researchers. The link of DM and TB is more prominent in developing countries where TB is endemic and the burden of diabetes mellitus is increasing. The association between diabetes and tuberculosis may be the next challenge for global tuberculosis control worldwide. Proper planning and collaboration are necessary to reduce the dual burden of diabetes and TB. One model similar to the TB-HIV program for prevention, screening and treatment of both diseases can be the best approach. In this paper, we review existing data and discuss the matters of controversy that would be helpful for determining research priorities in different countries. PMID:24360398

Maternal Responsiveness and Sensitivity Re-Considered: Some Is More

PubMed Central

Bornstein, Marc H.; Manian, Nanmathi

2013-01-01

Is it always or necessarily the case that common and important parenting practices are better insofar as they occur more often, or worse because they occur less often? Perhaps, less is more, or some is more. To address this question, we studied mothers’ microcoded contingent responsiveness to their infants (M = 5.4 months, SD = 0.2) in relation to independent global judgments of the same mothers’ parenting sensitivity. In a community sample of 335 European American dyads, videorecorded infant and maternal behaviors were timed microanalytically throughout an extended home observation; separately and independently, global maternal sensitivity was rated macroanalytically. Sequential analysis and spline regression showed that, as maternal contingent responsiveness increased, judged maternal sensitivity increased to significance on the contingency continuum, after which mothers who were even more contingent were judged less sensitive. Just significant levels of maternal responsiveness are deemed optimally sensitive. Implications of these findings for typical and atypical parenting, child development, and intervention science are discussed. PMID:24229542

The Discussion of Biotechnology Controversial Issues--An Exploratory Study about Its Potentialities.

ERIC Educational Resources Information Center

Rocha dos Reis, Pedro

This paper describes a qualitative research that used small group discussion activities centered in biotechnology and genetics controversies as a contribution to the promotion of students' thinking tools. Students' written conclusions and reflections about the activities, teachers' interviews, participant observation of the classes, and their…

European Community.

PubMed

1987-05-01

The European Community was established in 1951 to reconcile France and Germany after World War II and to make possible the eventual federation of Europe. By 1986, there were 12 member countries: France, Italy, Belgium, the Federal Republic of Germany, Luxembourg, the Netherlands, Denmark, Ireland, the United Kingdom, Greece, Spain, and Portugal. Principal areas of concern are internal and external trade, agriculture, monetary coordination, fisheries, common industrial and commercial policies, assistance, science and research, and common social and regional policies. The European Community has a budget of US$34.035 billion/year, funded by customs duties and 1.4% of each member's value-added tax. The treaties establishing the European Community call for members to form a common market, a common customs tariff, and common agricultural, transport, economic, and nuclear policies. Major European Community institutions include the Commission, Council of Ministers, European Parliament, Court of Justice, and Economic and Social Committee. The Community is the world's largest trading unit, accounting for 15% of world trade. The 2 main goals of the Community's industrial policy are to create an open internal market and to promote technological innovation in order to improve international competitiveness. The European Community aims to contribute to the economic and social development of Third World countries as well.

Perspective: Challenges and Controversial Issues in the Dietary Guidelines for Americans, 1980-2015.

PubMed

Nestle, Marion

2018-03-01

Since 1980, every edition of the Dietary Guidelines for Americans (DGAs) has recommended increased consumption of fruits, vegetables, and whole grains, but reduced consumption of saturated fat, sugars, and sodium and, therefore, their primary food sources. Every edition has generated controversy, mainly from producers of foods affected by "eat less" recommendations, particularly meat. Objections to the 2015 DGAs focused on environmental as well as scientific issues, but also on purported conflicts of interest among members of the Dietary Guidelines Advisory Committee. On this basis, critics induced Congress to authorize the National Academy of Medicine (NAM) to review the process of drawing up the guidelines. The NAM's 2017 reports should strengthen the process, but as long as science continues to support advice to reduce consumption of targeted foods, the guidelines will continue to elicit political controversy.

Role of circulation in European heatwaves using flow analogues

NASA Astrophysics Data System (ADS)

Jézéquel, Aglaé; Yiou, Pascal; Radanovics, Sabine

2018-02-01

The intensity of European heatwaves is connected to specific synoptic atmospheric circulation. Given the relatively small number of observations, estimates of the connection between the circulation and temperature require ad hoc statistical methods. This can be achieved through the use of analogue methods, which allow to determine a distribution of temperature conditioned to the circulation. The computation of analogues depends on a few parameters. In this article, we evaluate the influence of the variable representing the circulation, the size of the domain of computation, the length of the dataset, and the number of analogues on the reconstituted temperature anomalies. We tested the sensitivity of the reconstitution of temperature to these parameters for four emblematic recent heatwaves: June 2003, August 2003, July 2006 and July 2015. The paper provides general guidelines for the use of flow analogues to investigate European summer heatwaves. We found that Z500 is better suited than SLP to simulate temperature anomalies, and that rather small domains lead to better reconstitutions. The dataset length has an important influence on the uncertainty. We conclude by a set of recommendations for an optimal use of analogues to probe European heatwaves.

Controversial Issues in Healthcare Policy: A Survey of Doctor of Physical Therapy Students in a Public University.

PubMed

Snyder, Drew D; Bennett, Teale K; Oller, Jeremy C; Ge, Weiqing

2017-01-01

The recently passed legislation and proposed policy changes governing the healthcare system have been met with extensive debate and controversy. The primary objective of the study was to determine the attitudes of Doctor of Physical Therapy (DPT) students towards some of these controversial issues. The secondary objective was to determine the demographic factors, including number of years in a physical therapy program, that contribute to their attitude formation. The research design was a cross-sectional non-experimental survey. Purposive sampling was used to recruit subjects in a public university. Subjects took the survey including nine Likert scale questions/statements on controversial issues inspired from legislative efforts and news media sources and one open-ended question. Of the 111 recruited, 106 students agreed to participate as subjects and completed the survey. Only 18.9% agreed or strongly agreed that the Patient Protection and Affordable Care Act is a positive solution for the healthcare system in America. Political affiliation, class level, and developmental environment were associated with a few questions/statements. DPT students in the sample had very diverse attitudes towards controversial issues in healthcare policy. Some of these attitudes revealed very different paradigms from the results found among medical students and the general public.

Turkish Social Studies Teachers' Thoughts about the Teaching of Controversial Issues

ERIC Educational Resources Information Center

Copur, Ahmet; Demirel, Muammer

2016-01-01

In today's world, one of the primary goals of education is to raise individuals as citizens equipped with the skills of communication, high-level thinking, problem solving and questioning as well as with a global viewpoint. Introducing controversial issues into the classroom environment may be among the steps to be taken to achieve these goals. In…

Increasing Early Childhood Preservice Teachers' Intercultural Sensitivity through the ABCs

ERIC Educational Resources Information Center

Monroe, Lisa; Ruan, Jiening

2018-01-01

While the early childhood student population has become increasingly diverse in the U.S., its teaching force remains primarily European American. The diverse student population demands that early childhood educators possess intercultural sensitivity in order to teach their culturally diverse learners effectively. This study examined the…

Contrasting Viewpoints about Controversial Issues: Presenting Different Views on Highly Charged Issues.

ERIC Educational Resources Information Center

Goodwin, Jeff

1993-01-01

County agricultural agents (n=258) viewed the "What's the Beef/Here's the Beef" videos, which present contrasting viewpoints on animal rights. Results suggest that well-educated people who have emotional underpinnings on a controversial issue can have their attitudes moderated by exposure to an educational program. (JOW)

Truth in Packaging: Teaching Controversial Topics to Undergraduates in the Human Sciences.

ERIC Educational Resources Information Center

Fredericks, Marcel; Miller, Steven I.

1993-01-01

Argues that the behavioral or "human" sciences are fundamentally different in scope and intent from the natural sciences. Describes the use of controversial topics in undergraduate courses and provides a four-step process. Recommends using Karl Popper's falsification theory to help students think critically about issues. (CFR)

Transmuting Common Substances: The Cold Fusion Controversy and the Rhetoric of Science.

ERIC Educational Resources Information Center

Thacker, Brad; Stratman, James F.

1995-01-01

Explores the relationship among forensic, deliberative, and epideictic modes of rhetoric in the cold fusion controversy. Shows the interactions between three modes of rhetoric. Examines the ways in which the modes have shaped the emerging scientific consensus. Supports Robert Sanders' contention that rhetorical practices interact with scientific…

Consensus and controversies in best practices for molecular genetic testing of spinocerebellar ataxias

PubMed Central

Sequeiros, Jorge; Seneca, Sara; Martindale, Joanne

2010-01-01

Many laboratories worldwide are offering molecular genetic testing for spinocerebellar ataxias (SCAs). This is essential for differential diagnosis and adequate genetic counselling. The European Molecular Genetics Quality Network (EMQN) started an SCA external quality assessment scheme in 2004. There was a clear need for updated laboratory guidelines. EMQN and EuroGentest organized a Best Practice (BP) meeting to discuss current practices and achieve consensus. A pre-meeting survey showed that 36 laboratories (20 countries) conducted nearly 18 000 SCA tests the year before, and identified issues to discuss. Draft guidelines were produced immediately after the meeting and discussed online for several months. The final version was endorsed by EMQN, and harmonized with guidelines from other oligonucleotide repeat disorders. We present the procedures taken to organize the survey, BP meeting, as well as drafting and approval of BP guidelines. We emphasize the most important recommendations on (1) pre-test requirements, (2) appropriate methodologies and (3) interpretation and reporting, and focus on the discussion of controversial issues not included in the final document. In addition, after an extensive review of scientific literature, and responding to recommendations made, we now produce information that we hope will facilitate the activities of diagnostic laboratories and foster quality SCA testing. For the main loci, this includes (1) a list of repeat sequences, as originally published; (2) primers in use; and (3) an evidence-based description of the normal and pathogenic repeat-size ranges, including those of reduced penetrance and those in which there is still some uncertainty. This information will be maintained and updated in http://www.scabase.eu. PMID:20179748

Reliability of Growth Indicators and Efficiency of Functional Treatment for Skeletal Class II Malocclusion: Current Evidence and Controversies.

PubMed

Perinetti, Giuseppe; Contardo, Luca

2017-01-01

Current evidence on the reliability of growth indicators in the identification of the pubertal growth spurt and efficiency of functional treatment for skeletal Class II malocclusion, the timing of which relies on such indicators, is highly controversial. Regarding growth indicators, the hand and wrist (including the sole middle phalanx of the third finger) maturation method and the standing height recording appear to be most reliable. Other methods are subjected to controversies or were showed to be unreliable. Main sources of controversies include use of single stages instead of ossification events and diagnostic reliability conjecturally based on correlation analyses. Regarding evidence on the efficiency of functional treatment, when treated during the pubertal growth spurt, more favorable response is seen in skeletal Class II patients even though large individual responsiveness remains. Main sources of controversies include design of clinical trials, definition of Class II malocclusion, and lack of inclusion of skeletal maturity among the prognostic factors. While no growth indicator may be considered to have a full diagnostic reliability in the identification of the pubertal growth spurt, their use may still be recommended for increasing efficiency of functional treatment for skeletal Class II malocclusion.

Reliability of Growth Indicators and Efficiency of Functional Treatment for Skeletal Class II Malocclusion: Current Evidence and Controversies

PubMed Central

2017-01-01

Current evidence on the reliability of growth indicators in the identification of the pubertal growth spurt and efficiency of functional treatment for skeletal Class II malocclusion, the timing of which relies on such indicators, is highly controversial. Regarding growth indicators, the hand and wrist (including the sole middle phalanx of the third finger) maturation method and the standing height recording appear to be most reliable. Other methods are subjected to controversies or were showed to be unreliable. Main sources of controversies include use of single stages instead of ossification events and diagnostic reliability conjecturally based on correlation analyses. Regarding evidence on the efficiency of functional treatment, when treated during the pubertal growth spurt, more favorable response is seen in skeletal Class II patients even though large individual responsiveness remains. Main sources of controversies include design of clinical trials, definition of Class II malocclusion, and lack of inclusion of skeletal maturity among the prognostic factors. While no growth indicator may be considered to have a full diagnostic reliability in the identification of the pubertal growth spurt, their use may still be recommended for increasing efficiency of functional treatment for skeletal Class II malocclusion. PMID:28168195

The portrayal of J. Marion Sims' controversial surgical legacy.

PubMed

Spettel, Sara; White, Mark Donald

2011-06-01

In the mid 1800s Dr. J. Marion Sims reported the successful repair of vesicovaginal fistulas with a technique he developed by performing multiple operations on female slaves. A venerated physician in his time, the legacy of Dr. Sims is controversial and represents a significant chapter in the mistreatment of African-Americans by the medical establishment. This review compares the modern debate surrounding his legacy with the presentation of his operation in widely consulted urological texts and journals. A literature review was performed of medical, sociological and periodical sources (1851 to the present) regarding J. Marion Sims and vesicovaginal fistula repair. During the last several decades, while the controversy around Dr. Sims' surgical development has produced a steady stream of articles in the historical and popular literature, relatively little mention is found in standard urology textbooks or journals. With increased public attention, some have debated the removal or modification of public tributes to Dr. Sims. This move has been countered by arguments against the validity of judging a 19th century physician by modern standards. While historians, ethicists and the popular press have debated Dr. Sims' legacy, medical sources have continued to portray him unquestionably as a great figure in medical history. This division keeps the medical profession uninformed and detached from the public debate on his legacy and, thus, the larger issues of ethical treatment of surgical patients. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Activation of innate immunity modulates insulin sensitivity, glucose effectiveness and pancreatic β-cell function in both African ancestry and European ancestry healthy humans.

PubMed

Ferguson, Jane F; Shah, Rhia Y; Shah, Rachana; Mehta, Nehal N; Rickels, Michael R; Reilly, Muredach P

2015-04-01

Insulin resistance is a risk factor for type 2 diabetes, and is associated with inflammatory cardiometabolic disease. Given differences between African ancestry (AA) and European ancestry (EA) in the epidemiology of type 2 diabetes as well as in response to inflammatory stress, we investigated potential race differences in glucose homeostasis responses during experimental endotoxemia in humans. Healthy volunteers (age 18-45 years, BMI 18-30 kg/m(2), 47% female, African-ancestry (AA, n=42) and European-ancestry (EA, n=106)) were recruited as part of the Genetics of Evoked Responses to Niacin and Endotoxemia (GENE) Study. Subjects underwent an inpatient endotoxin challenge (1 ng/kg LPS) and two frequently-sampled intravenous glucose tolerance tests (FSIGTT). Insulin and glucose values obtained during FSIGTT pre- and 24-hours post-LPS were analyzed using the minimal model. FSIGTT derived insulin sensitivity index (SI), disposition index (DI) and glucose effectiveness (SG) decreased significantly following LPS (p<0.0001) while the acute insulin response to glucose (AIR(g)) increased (p<0.0001). Although expected race differences were observed in glucose homeostasis parameters at baseline prior to LPS e.g., lower SI (2.5 vs. 4.1 μU/L/min, p<0.0001) but higher AIR(g) (median 848 vs. 290 μU/L/min, p<0.0001) in AA vs. EA, the changes in glucose homeostasis responses to LPS were directionally and proportionally consistent across race e.g., SI median -35% in EA and -29% in AA and AIR(g) median +17% in EA and +26% in AA. Both EA and AA samples modulated glucose and insulin homeostasis similarly during endotoxemia. Race differences in response to environmental inflammatory stress are unlikely to be a substantial contributor to the observed difference in diabetes incidence and complications between EA and AA. Copyright © 2015 Elsevier Inc. All rights reserved.

A Controversial Reform in Indigenous Education: The Cape York Aboriginal Australian Academy

ERIC Educational Resources Information Center

McCollow, John

2012-01-01

This article examines a controversial initiative in Indigenous education: the establishment of the Cape York Aboriginal Australian Academy (CYAAA). The article provides a brief description of the Academy's three campuses and their communities and considers: the circumstances of its creation, including the role of Noel Pearson and Cape York…

Improving Vocational Students' Consideration of Source Information When Deciding about Science Controversies

ERIC Educational Resources Information Center

Stadtler, Marc; Scharrer, Lisa; Macedo-Rouet, Monica; Rouet, Jean-François; Bromme, Rainer

2016-01-01

We present an empirical investigation of a classroom training fostering vocational students' consideration of source information when deciding about science-based controversies. The training was specifically aimed at raising students' awareness of the division of cognitive labor and the resulting need to take a source's competence into account…

"We Must Look at Both Sides"--But a Denial of Genocide Too?: Difficult Moments on Controversial Issues in the Classroom

ERIC Educational Resources Information Center

Kubota, Ryuko

2014-01-01

In language education, controversial issues sometimes emerge in either planned or spontaneous ways. Based on a classroom episode, this article illuminates dilemmas of approaching controversial issues for teachers who embrace critical pedagogy. A review of interdisciplinary literature demonstrates a general agreement on presenting balanced views…

Rate vs. rhythm control and adverse outcomes among European patients with atrial fibrillation.

PubMed

Purmah, Yanish; Proietti, Marco; Laroche, Cecilé; Mazurek, Michal; Tahmatzidis, Dimitrios; Boriani, Giuseppe; Novo, Salvatore; Lip, Gregory Y H

2018-02-01

The impact of rate and rhythm control strategies on outcomes in patients with atrial fibrillation (AF) remains controversial. Our aims were: to report use of rate and rhythm control strategies in European patients from the EURObservational Research Program AF General Pilot Registry. Secondly, to evaluate outcomes according to assigned strategies. Use of pure rate and rhythm control agents was described according to European regions. 1-year follow-up data were reported. Among rate control strategies, beta-blockers were the most commonly used drug. Proportions of patients assigned to rhythm control varied greatly between countries, and amiodarone was the most used rhythm control drug. Of the original 3119 patients, 1036 (33.2%) were assigned to rate control only and 355 (11.4%) to rhythm control only. Patients assigned to a rate control strategy were older (P < 0.0001) and more likely female (P = 0.0266). Patients assigned to a rate control strategy had higher rates for any thrombo-embolic event (P = 0.0245), cardiovascular death (P = 0.0437), and all-cause death (P < 0.0001). Kaplan-Meier analysis showed that rate control strategy was associated with a higher risk for all-cause death (P < 0.001). On Cox regression analysis, rate control strategy was independently associated with all-cause death (P = 0.0256). A propensity matched analysis only found a trend for the association between rate control and all-cause death (P = 0.0664). In a European AF patients' cohort, a pure rate control strategy was associated with a higher risk for adverse events at 1-year follow-up, and partially adjusted analysis suggested that rate control independently increased the risk for all-cause death. A fully adjusted propensity score matched analysis found that this association was no longer statistically significant, suggesting an important role of comorbidities in determining the higher risk for all-cause death. Published on behalf of the European Society

Promoting the role of the personal narrative in teaching controversial socio-scientific issues

NASA Astrophysics Data System (ADS)

Levinson, Ralph

2008-09-01

Citizens participating in contemporary socio-scientific issues (SSI) need to draw on local knowledge and personal experience. If curricular developments in the teaching of controversial SSI are to reflect contemporary notions of citizenship then the personal narrative is an indispensable instrument in bridging the gap between the local/personal and the emergent science. In the context of controversy personal narratives help contending parties to see events in the light of those who do not share their views. A goal-oriented protagonist is the narrator in the personal narrative, which consists of three components - situation-event-reaction—the reaction being an evaluation of the event. Promoting personal narratives in science-based curricula is considered problematic given the dominant role of science’s explanatory frameworks. An inter-disciplinary approach is proposed based on McLaughlin’s levels of disagreement.

Resolving controversies in hip fracture care: the need for large collaborative trials in hip fractures.

PubMed

Bhandari, Mohit; Sprague, Sheila; Schemitsch, Emil H

2009-07-01

Hip fractures are a significant cause of morbidity and mortality worldwide and the burden of disability associated with hip fractures globally vindicate the need for high-quality research to advance the care of patients with hip fractures. Historically, large, multi-centre randomized controlled trials have been rare in the orthopaedic trauma literature. Similar to other medical specialties, orthopaedic research is currently undergoing a paradigm shift from single centre initiatives to larger collaborative groups. This is evident with the establishment of several collaborative groups in Canada, in the United States, and in Europe, which has proven that multi-centre trials can be extremely successful in orthopaedic trauma research.Despite ever increasing literature on the topic of his fractures, the optimal treatment of hip fractures remains unknown and controversial. To resolve this controversy large multi-national collaborative randomized controlled trials are required. In 2005, the International Hip Fracture Research Collaborative was officially established following funding from the Canadian Institute of Health Research International Opportunity Program with the mandate of resolving controversies in hip fracture management. This manuscript will describe the need, the information, the organization, and the accomplishments to date of the International Hip Fracture Research Collaborative.

Winter precipitation forecast in the European and Mediterranean regions using cluster analysis

NASA Astrophysics Data System (ADS)

Molnos, S.

2017-12-01

The European and Mediterranean climates are sensitive to large-scale circulation of the atmosphere andocean making it difficult to forecast precipitation or temperature on seasonal time-scales. In addition, theMediterranean region has been identified as a hotspot for climate change and already today a drying in theMediterranean region is observed.Thus, it is critically important to predict seasonal droughts as early as possible such that water managersand stakeholders can mitigate impacts.We developed a novel cluster-based forecast method to empirically predict winter's precipitationanomalies in European and Mediterranean regions using precursors in autumn. This approach does notonly utilizes the amplitude but also the pattern of the precursors in generating the forecast.Using a toy model we show that it achieves a better forecast skill than more traditional regression models. Furthermore, we compare our algorithm with dynamic forecast models demonstrating that our prediction method performs better in terms of time and pattern correlation in the Mediterranean and European regions.

Controversy in the Psychology Classroom: Using Hot Topics to Foster Critical Thinking

ERIC Educational Resources Information Center

Dunn, Dana S., Ed.; Gurung, Regan A. R., Ed.; Naufel, Karen Z., Ed.; Wilson, Janie H., Ed.

2012-01-01

One of the hallmarks of a quality liberal arts education is providing undergraduates the opportunity to wrestle with controversial issues. Yet many teachers feel ill-equipped when it comes to broaching disagreeable topics, managing the resulting heated debates, or helping students to separate their personal feelings from scientific evidence. This…

Justifying the Use of Internet Sources in School Assignments on Controversial Issues

ERIC Educational Resources Information Center

Mikkonen, Teemu

2018-01-01

Introduction: This study concerns students' criteria in the evaluation of Internet sources for a school assignment requiring reflections on a controversial issue. The findings are elaborated by analysing students' discursive accounts in justifying the use or non-use of sources. Method: The interview data was collected in a Finnish upper secondary…

Ensuing Dog Fight: The AHA Commission on the Social Studies' Testing Controversy

ERIC Educational Resources Information Center

Schul, James E.

2013-01-01

The American Historical Association's (AHA's) Commission on the Social Studies was a compilation of prominent scholars who, from 1929 to 1934, investigated social studies education in American public schools in order to provide some cohesive recommendations for teachers. The AHA Commission had a controversial ending, with one of its members,…

The Safford, Arizona, Murals of Seymour Fogel: A Study in Artistic Controversy.

ERIC Educational Resources Information Center

Fogel, Jared A.; Stevens, Robert L.

1996-01-01

Examines the controversy generated by art works commissioned by the Works Progress Administration (WPA). Attempting to create work for depression-era artists, the WPA often commissioned murals for government buildings. Recounts the experience of Seymour Fogel, who's positive portrayal of Native Americans ran afoul of racist sentiments in Safford,…

Entanglements of Consumption, Cruelty, Privacy, and Fashion: The Social Controversy over Fur.

ERIC Educational Resources Information Center

Olson, Kathryn M.; Goodnight, G. Thomas

1994-01-01

Posits a critical approach to the study of contemporary social controversy. Examines objectives to the use of fur as oppositional argument, rhetoric that veers from the goal of persuasion to block conventional associations and refashion communication norms. Shows how pro-fur responses illustrate strategies available to bolster, alter, or abandon…

Media Misrepresentations of a Mascot Controversy: Contested Constructions of Race and Gender

ERIC Educational Resources Information Center

Gerstl-Pepin, Cynthia; Liang, Guodong

2010-01-01

This article examines media coverage of a high school Native American mascot controversy. Discourse analysis of media documents and artifacts was utilized to explore how the issue was socially constructed for public consumption. Critical race feminism was used as a framework to examine how media discourses can oversimplify the complex interaction…

Argument, Counterargument, and Integration? Patterns of Argument Reappraisal in Controversial Classroom Discussions

ERIC Educational Resources Information Center

Gronostay, Dorothee

2016-01-01

Being challenged by opposing views in a controversial discussion can stimulate the production of more elaborate and sophisticated argumentations. According to the model of argument reappraisal (Leitão, 2000), such processes require transactivity, meaning that students do not only give reasons to support their own position (e.g., pro/contra…

Neurosteroid Influences on Sensitivity to Ethanol

PubMed Central

Helms, Christa M.; Rossi, David J.; Grant, Kathleen A.

2011-01-01

This review will highlight a variety of mechanisms by which neurosteroids affect sensitivity to ethanol, including physiological states associated with activity of the hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–gonadal (HPG) axes, and the effects of chronic exposure to ethanol, in addition to behavioral implications. To date, γ-aminobutyric acid (GABAA) receptor mechanisms are a major focus of the modulation of ethanol effects by neuroactive steroids. While NMDA receptor mechanisms are gaining prominence in the literature, these complex data would be best discussed separately. Accordingly, GABAA receptor mechanisms are emphasized in this review with brief mention of some NMDA receptor mechanisms to point out contrasting neuroactive steroid pharmacology. Overall, the data suggest that neurosteroids are virtually ubiquitous modulators of inhibitory neurotransmission. Neurosteroids appear to affect sensitivity to ethanol in specific brain regions and, consequently, specific behavioral tests, possibly related to the efficacy and potency of ethanol to potentiate the release of GABA and increase neurosteroid concentrations. Although direct interaction of ethanol and neuroactive steroids at common receptor binding sites has been suggested in some studies, this proposition is still controversial. It is currently difficult to assign a specific mechanism by which neuroactive steroids could modulate the effects of ethanol in particular behavioral tasks. PMID:22654852

[Post-traumatic stress disorder and psychological debriefing: a controversial topic].

PubMed

Debabèche, C; Ansseau, M; Pitchot, W

2012-01-01

The last decades have demonstrated the value of early interventions after a traumatic event. The purpose of these interventions is to prevent the development of psychological consequences such as post-traumatic stress disorder. Psychological debriefing is clearly the most popular intervention. However, in the literature, it is subject to a real controversy. The objective of the present paper is to define the interest of psychological debriefing, but also alternative therapeutical strategies for people exposed to traumatic events.

Preimplantation and prenatal diagnosis, wrongful birth and wrongful life: a global view of bioethical and legal controversies.

PubMed

Frati, Paola; Fineschi, Vittorio; Di Sanzo, Mariantonia; La Russa, Raffaele; Scopetti, Matteo; Severi, Filiberto M; Turillazzi, Emanuela

2017-05-01

Prenatal diagnosis based on different technologies is increasingly used in developed countries and has become a common strategy in obstetric practice. The tests are crucial in enabling mothers to make informed decisions about the possibility of terminating pregnancy. They have generated numerous bioethical and legal controversies in the field of 'wrongful life' claims (action brought by or on behalf of a child against the mother or other people, claiming that he or she has to endure a not-worth-living existence) and 'wrongful birth' claims (action brought by the mother or parents against the physician for being burdened with an unwanted, often disabled child, which could have been avoided). The possibility which exists nowadays to intervene actively by programming and deciding the phases linked to procreation and birth has raised several questions worldwide. The mother's right to self-determination could be an end but whether or not this right is absolute is debatable. Freedom could, with time, act as a barrier that obstructs intrusion into other people's lives and their personal choices. Therapeutic choices may be manageable in a liberal sense, and the sanctity of life can be inflected in a secular sense. These sensitive issues and the various points of view to be considered have motivated this review. Literature searches were conducted on relevant demographic, social science and medical science databases (SocINDEX, Econlit, PopLine, Medline, Embase and Current Contents) and via other sources. Searches focused on subjects related to bioethical and legal controversies in the field of preimplantation and prenatal diagnosis, wrongful birth and wrongful life. A review of the international state of law was carried out, focusing attention on the peculiar issue of wrongful life and investigating the different jurisdictional solutions of wrongful life claims in a comparative survey. Courts around the world are generally reluctant to acknowledge wrongful life claims due to

[After ACC/AHA and ESC Guidelines: Pre-operative cardiological evaluation in non-cardiac surgery: certainties, controversial areas and opportunities for a team approach].

PubMed

Urbinati, Stefano; Faggiano, Pompilio; Colivicchi, Furio; Riccio, Carmine; Abrignani, Maurizio Giuseppe; Genovesi-Ebert, Alberto; Fattirolli, Francesco; De Feo, Stefania; Gambetti, Simona; Uguccioni, Massimo

2011-09-01

A standardized and evidence-based approach to the cardiological management of patients undergoing noncardiac surgery has been recently defined by Task Forces of the American Heart Association (AHA), American College of Cardiology (ACC) and the European Society of Cardiology (ESC) that published their guidelines in 2007 and 2009, respectively. Both the recommendations moved from risk indices to a practical, stepwise approach of the patient, which integrates clinical risk factors and test results with the estimated stress of the planned surgical procedure. In the present paper the main topics of the guidelines are discussed, and moreover, emphasis is placed on four controversial issues such as the use of prophylactic coronary revascularization in patients with myocardial ischemia, the perioperative management of patients with congestive heart failure, the routine use of betablockers and statins, and, finally, the management of antiplatelet therapies in patients with coronary stents. In addition to promoting an improvement of immediate perioperative care, the preoperative cardiological evaluation should be a challenge for identifying subjects with enhanced risk of cardiovascular events, who should be treated and monitored during a long-term follow-up.

Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project.

PubMed

Letovanec, Igor; Finn, Stephen; Zygoura, Panagiota; Smyth, Paul; Soltermann, Alex; Bubendorf, Lukas; Speel, Ernst-Jan; Marchetti, Antonio; Nonaka, Daisuke; Monkhorst, Kim; Hager, Henrik; Martorell, Miguel; Sejda, Aleksandra; Cheney, Richard; Hernandez-Losa, Javier; Verbeken, Eric; Weder, Walter; Savic, Spasenija; Di Lorito, Alessia; Navarro, Atilio; Felip, Enriqueta; Warth, Arne; Baas, Paul; Meldgaard, Peter; Blackhall, Fiona; Dingemans, Anne-Marie; Dienemann, Hendrik; Dziadziuszko, Rafal; Vansteenkiste, Johan; O'Brien, Cathal; Geiger, Thomas; Sherlock, Jon; Schageman, Jeoffrey; Dafni, Urania; Kammler, Roswitha; Kerr, Keith; Thunnissen, Erik; Stahel, Rolf; Peters, Solange

2018-03-01

The reported prevalence of ALK receptor tyrosine kinase gene (ALK) rearrangement in NSCLC ranges from 2% to 7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proved to be a reproducible and sensitive technique. Reverse-transcriptase polymerase chain reaction (RT-PCR) has also been advocated, and most recently, the advent of targeted next-generation sequencing (NGS) for ALK and other fusions has become possible. This study compares anaplastic lymphoma kinase (ALK) evaluation with all four techniques in resected NSCLC from the large European Thoracic Oncology Platform Lungscape cohort. A total of 96 cases from the European Thoracic Oncology Platform Lungscape iBiobank, with any ALK immunoreactivity were examined by FISH, central RT-PCR, and NGS. An H-score higher than 120 defines IHC positivity. RNA was extracted from the same formalin-fixed, paraffin-embedded tissues. For RT-PCR, primers covered the most frequent ALK translocations. For NGS, the Oncomine Solid Tumour Fusion Transcript Kit (Thermo Fisher Scientific, Waltham, MA) was used. The concordance was assessed using the Cohen κ coefficient (two-sided α ≤ 5%). NGS provided results for 77 of the 95 cases tested (81.1%), whereas RT-PCR provided results for 77 of 96 (80.2%). Concordance occurred in 55 cases of the 60 cases tested with all four methods (43 ALK negative and 12 ALK positive). Using ALK copositivity for IHC and FISH as the criterion standard, we derived a sensitivity for RT-PCR/NGS of 70.0%/85.0%, with a specificity of 87.1%/79.0%. When either RT-PCR or NGS was combined with IHC, the sensitivity remained the same, whereas the specificity increased to 88.7% and 83.9% respectively. NGS evaluation with the Oncomine Solid Tumour Fusion transcript kit and RT-PCR proved to have high sensitivity and specificity, advocating their use in routine practice. For maximal sensitivity and specificity, ALK status should be

How "Bright" is it to Use CFLs? A Look at the Controversy

ERIC Educational Resources Information Center

Miller, Roxanne Greitz

2008-01-01

Commonly referred to as CFLs, compact fluorescent light bulbs are rapidly replacing traditional incandescent light bulbs for residential use. However, controversy and even comic parody have arisen surrounding CFL use. CFLs contain small amounts of mercury, and several public forums and news agencies have been announcing that the breakage of a CFL…

The American Trial Jury: Current Issues and Controversies. Looking at the Law.

ERIC Educational Resources Information Center

Ryan, John Paul

1999-01-01

Discusses the controversial issues involved in the jury systems, such as jury selection, jury service, civic participation, and the role of the mass media. Stresses the importance of maintaining the public courtroom as a means for encouraging fair trials and not allowing closed courtrooms. Provides an accompanying article, "The Citizen's Jury," by…

Science News of Controversy: The Case of Marijuana. Journalism Monographs No. 62.

ERIC Educational Resources Information Center

Shepherd, R. Gordon

1979-01-01

A study of news refraction was conducted to determine how well the press has functioned in popularizing scientific views and findings on a subject with direct implications for a controversial social issue. In reporting the marijuana question, the press produced a certain amount of refraction or news-slanting. For example, science articles…

On ```Walking on Water' and the Geoscientists' Fear of Social Controversy''

NASA Astrophysics Data System (ADS)

Book, David L.

2006-10-01

In ```Walking on water' and the geoscientists' fear of social controversy'' (Eos, 87(39),2006), Doron Nof describes how he and two colleagues published an article in the Journal of Paleolimnology offering a `natural explanation' for the legend that Jesus walked on water. He argues that ``the more light we shed on whatever the rest of society thinks and does, the more appreciated science will become.''

History of Concurrency. The Controversy of Military Acquisition Program Schedule Compression

DTIC Science & Technology

1986-09-01

33 The Manhattan Project . ........... 35 Post-War Acquisition . . . . ...... 40 The Lockheed Skunk Works ........ 42 iii Era of Controversy...been involved Vin the Manhattan Project (47:55). The concurrency concept and the innovative foundation of the Air Force Ballistic Missile Program...inter- F4 continental oallistic missile. To snorten the program’s development time they drew upon lessons from the Manhattan Project and made three

A confusion of tongues between psychoanalysis and philosophy: is the controversy over drive versus relational theory a philosophical one?

PubMed

Taub, Gadi

2009-06-01

In recent years the controversy over Drive versus Relational models of the psyche has become entangled in a philosophical controversy over epistemology. Some have argued that the Drive model was a relic of an age of positivistic science, while Relational models are a product of a postmodern condition. This paper argues that the controversy need not be a philosophical one, and that Relational views are not, in fact, a product of postmodernism, nor are they necessarily dependent on a postmodern epistemology. Separating the epistemological from the psychological more carefully may help return the debate to its proper, psychoanalytic domain, and perhaps contribute to a more fruitful dialogue across what, at times, seems like an abyss between Relational views and Drive theory.

Contact sensitivity to preservatives in Singapore: frequency of sensitization to 11 common preservatives 2006-2011.

PubMed

Cheng, Suzanne; Leow, Yung Hian; Goh, Chee Leok; Goon, Anthony

2014-01-01

Preservatives are indispensable agents used to prevent bacterial and fungal contamination of cosmetics, personal care products, domestic preparations, and industrial products. We evaluated patch-test data at the National Skin Centre, Singapore, from 2006 to 2011 to identify the trends in preservative contact allergies. All patients with suspected contact dermatitis were patch tested to 4 preservatives within the modified European standard series. Patients were also tested with 7 preservatives from our special series if clinically indicated. Three thousand one hundred seventy-seven patients were tested to preservatives in the standard series. Sensitization frequencies were all greater than 1%: parabens (2.58%), methylchloroisothiazolinone/methylisothiazolinone (1.75%), quaternium 15 (1.43%), and methyldibromoglutaronitrile (1.2%). There was no change in trends in sensitization frequencies from 2006 to 2011, with no increase in sensitization frequency to methylchloroisothiazolinone/methylisothiazolinone. The sensitization frequencies for methyldibromoglutaronitrile/phenoxyethanol and diazolidinylurea were 2.03% and 1.37%, respectively, and remained less than 1% for bronopol, imidazolidinyl urea, and 2-phenoxyethanol. A rate of 0% was seen for 1,3-dimethylol-5,5-dimethyl hydantoin and formaldehyde; 9.4% of positive patch-test results became positive only at day 7. Preservatives are common causes of allergic contact dermatitis. This should be considered when introducing new preservatives into the market. Day 7 readings are important to detect late reactions.

Listening in the Pakal controversy: a matter of care in Ancient Maya studies.

PubMed

Watson, Matthew C

2014-12-01

This article explores the fraught historical politics of a 20th-century controversy over a Classic Maya king. The controversy ostensibly concerned the age at death of a ruler discovered in 1952 in an elaborate sarcophagus at the Mexican site of Palenque. Combining osteological and epigraphic techniques, Mexican scholars estimated that the ruler died at about 40 or 50years of age. Two decades later, an emerging collective of US hieroglyph experts claimed to have determined the grammatical structure of Maya glyphs for the first time and reevaluated the sarcophagus inscriptions. They concluded that the king, given the name 'Pakal', lived a remarkably long life of 80years (603-683 CE). This reading sparked a controversy that would persist until 1999. At stake was not just how to tell the story of an ancient Maya lord, but who could tell it, with what evidence, and with what degree of certainty. The inclination of some Mexican archaeologists to adopt nationalist and Marxist orientations came into palpable tension with foreign scholars' liberal, universalist knowledge practices. To address this problem, I rethink Pakal's material mediation through bones and inscriptions as a 'matter of concern' (Bruno Latour) and 'matter of care' (Maria Puig de la Bellacasa). I show how these concepts facilitate the reconsideration of contradictory historical propositions as potential sites of coexistence among actors temporarily ill equipped to listen to each other's claims. Ultimately, I present 'listening' as a technique of cosmopolitical care that complements the extensive emphasis on speech and spokespersonship in Latourian cosmopolitics.

Element 74, the Wolfram Versus Tungsten Controversy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holden,N.E.

Two and a quarter centuries ago, a heavy mineral ore was found which was thought to contain a new chemical element called heavy stone (or tungsten in Swedish). A few years later, the metal was separated from its oxide and the new element (Z=74) was called wolfram. Over the years since that time, both the names wolfram and tungsten were attached to this element in various countries. Sixty years ago, IUPAC chose wolfram as the official name for the element. A few years later, under pressure from the press in the USA, the alternative name tungsten was also allowed bymore » IUPAC. Now the original, official name 'wolfram' has been deleted by IUPAC as one of the two alternate names for the element. The history of this controversy is described here.« less

Teaching the Philosophical Interpretations of Quantum Mechanics and Quantum Chemistry through Controversies

ERIC Educational Resources Information Center

Garritz, Andoni

2013-01-01

This study has the key premise of teaching history and philosophy of physical sciences to illustrate how controversies and rivalries among scientists play a key role in the progress of science and why scientific development is not only founded on the accumulation of experimental data. The author is a defender of teachers who consider…

Controversy in the Composition Classroom: Debate as a Mode of Pre-Writing.

ERIC Educational Resources Information Center

McClish, Glen

Controversy and debate can be effectively employed as the central pre-writing activity in the composition classroom. The current model of prewriting in the composition classroom is the reflective model, which involves relatively private exploration of issues and ideas leading to paper topics. Although in the short run it is easier for both student…

For a Psycholinguistic Model of Handwriting Production: Testing the Syllable-Bigram Controversy

ERIC Educational Resources Information Center

Kandel, Sonia; Peereman, Ronald; Grosjacques, Geraldine; Fayol, Michel

2011-01-01

This study examined the theoretical controversy on the impact of syllables and bigrams in handwriting production. French children and adults wrote words on a digitizer so that we could collect data on the local, online processing of handwriting production. The words differed in the position of the lowest frequency bigram. In one condition, it…

Teaching Controversial Environmental Issues: Neutrality and Balance in the Reality of the Classroom

ERIC Educational Resources Information Center

Cotton, Deborah R. E.

2006-01-01

Background: Environmental issues are frequently controversial and involve conflicting interests and values. Much environmental education literature explicitly encourages teachers to promote pro-environmental attitudes and behaviours amongst their students, despite evidence that teacher support for such a policy is ambiguous at best. The literature…

Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms

PubMed Central

Shou, Wenying

2015-01-01

Cooperators who pay a cost to produce publically-available benefits can be exploited by cheaters who do not contribute fairly. How might cooperation persist against cheaters? Two classes of mechanisms are known to promote cooperation: 'partner choice', where a cooperator preferentially interacts with cooperative over cheating partners; and 'partner fidelity feedback', where repeated interactions between individuals ensure that cheaters suffer as their cooperative partners languish (see, for example, Momeni et al., 2013). However when both mechanisms can act, differentiating them has generated controversy. Here, I resolve this controversy by noting that selection can operate on organismal and sub-organismal 'entities' such that partner fidelity feedback at sub-organismal level can appear as partner choice at organismal level. I also show that cooperation between multicellular eukaryotes and mitochondria is promoted by partner fidelity feedback and partner choice between sub-organismal entities, in addition to being promoted by partner fidelity feedback between hosts and symbionts, as was previously known. DOI: http://dx.doi.org/10.7554/eLife.10106.001 PMID:26714105

Tooth-bleaching procedures and their controversial effects: A literature review

PubMed Central

Alqahtani, Mohammed Q.

2014-01-01

Aim This review article will help clinicians improve their understanding of the history of bleaching procedures, bleaching types, components, mechanisms, and their effects on soft tissue, tooth structures, resin composite, and bonding. Methods The controversial issues about bleaching procedures and their effects are reviewed. Additionally, the consequences of pre- and post-bleaching on the bonding potential of composite resin restorations to tooth structure are discussed. Conclusion The overall goal of the paper is to help reduce risks for patients. PMID:25408594

Lyme disease: why the controversy?

PubMed

Beaman, M H

2016-12-01

Some Australians have become convinced of the existence of locally acquired Lyme disease (LD). The history of LD, since its recognition in the early 1970s, is reviewed as a model for investigative approaches to unknown syndromes. Australian Management Guidelines for LD include the requirement for diagnostic testing by National Association of Testing Authorities-accredited laboratories using Therapeutic Goods Administration-licensed tests, which result in the efficient diagnosis of LD in overseas travellers. Despite this, patients who have not left Australia pay many thousands of dollars for non-specialist consultations and testing at overseas laboratories. Unproven long-term therapy with multiple antibiotics has resulted in serious complications, including allergies, line sepsis, pancreatitis and pseudomembranous colitis. Studies have shown that LD vectors are not found in Australia, and Lyme Borrelia has not been found in Australian vectors, animals or patients with autochthonous illnesses. I propose that (i) A non-controversial name for the chronic syndrome should be adopted, 'Australian Multisystem Disorder'. (ii) Research funding should enable the development of a consensus case definition and studies of the epidemiology of this syndrome with laboratory investigations to identify an aetiology and surrogate markers of disease. Prospective, randomised treatment studies could then be undertaken using ethical protocols. © 2016 Royal Australasian College of Physicians.

Simultaneous sensitivity to fragrances.

PubMed

Buckley, D A; Basketter, D A; Smith Pease, C K; Rycroft, R J G; White, I R; McFadden, J P

2006-05-01

Cinnamal/cinnamic alcohol and isoeugenol/eugenol are pairs of related fragrance chemicals found in Fragrance Mix I (FM I), and thus are routinely tested in combination with other fragrances in the European standard patch test series. Their close structural similarity makes the occurrence of simultaneous sensitivity within these chemical pairs likely, although at present there are no robust data to support this hypothesis. To establish the frequency of simultaneous reactions to these fragrance chemicals in patients with suspected fragrance allergy attending a contact dermatitis clinic; to provide evidence in support of proposed metabolic pathways; and to determine whether including all four separately in FM I is necessary to avoid missing a diagnosis of fragrance allergy. We analysed retrospectively the records of patients patch tested to the European standard series during the 15-year period 1984-98 for positive reactions to FM I. In a subset of patients tested to the constituents of FM I, positive reactions to cinnamal, cinnamic alcohol, isoeugenol and eugenol were sought. Data were analysed using 2x2 contingency tables (Fisher's exact test). During this period, 23,660 patients were tested to the European standard series, of whom 1811 (7.7%) had positive reactions to FM I. Of the 1112 patients tested to the constituents of FM I, 934 had positive reactions to at least one constituent (total 1324 positive reactions to constituents). Of these 934, 826 also had positive reactions to FM I itself; 108 were negative to FM I but reacted to one or more of its constituents. One hundred and seventy-eight patients did not react to any of the breakdown constituents of FM I; 34 of these had positive reactions to FM I itself. Of 139 patients allergic to cinnamic alcohol, 87 were also allergic to cinnamal (63%), compared with 108 (11.1%) of 973 cinnamic alcohol-negative patients (P<0.00001). Of 231 patients allergic to isoeugenol, 50 were also allergic to eugenol (22%), vs. 109

U.S. Military Aviation Mishaps In Japan and Okinawan Political Controversy

DTIC Science & Technology

2015-12-01

political controversy over U.S. bases in Japan, the American presence in the island country has proven its strategic advantages for the United States...CONTEMPORARY OKINAWAN HISTORY Located approximately 400 miles south of mainland Japan, Okinawa is the largest island in the Ryukyu Island chain. In the 17th...century, Okinawa served as tributary state to both China and Japan. Commerce brought additional influences to the island , helping to shape a

Discoveries and controversies in cutaneous mosaicism.

PubMed

Castori, Marco; Tadini, Gianluca

2016-06-01

Genetic mosaicism is thought to be a common phenomenon in inherited skin disorders. It is the leading molecular mechanism explaining cutaneous hamartomas and nevoid disorders, skin manifestations of most X-linked genodermatoses and specific forms of clinical variability and topographic distribution in autosomal skin disorders. The developmental (in utero) origin and timing dependence are two major attributes for the current definition of cutaneous mosaicism. Chromosomal mosaicism, lyonization in X-linked genodermatoses, and various types of mosaicism (i.e. type 1, type 2 and revertant mosaicism) in autosomal skin disorders are mechanisms well defined at the molecular level. All these concepts have been fully included in the current medical terminology in dermatology and genetics. Mitotic crossing-over, paradominant inheritance, monoallelic expression of autosomal traits and mosaicism in acquired skin disorders remain without a formal molecular proof and still represent sources of debate in the scientific community. This review summarizes current concepts, discoveries and controversies in the field of cutaneous mosaicism for practitioners and clinical researchers to enhance their understanding of such a underestimated clinical phenomenon and its biological basis.

Can we detect a nonlinear response to temperature in European plant phenology?

PubMed

Jochner, Susanne; Sparks, Tim H; Laube, Julia; Menzel, Annette

2016-10-01

Over a large temperature range, the statistical association between spring phenology and temperature is often regarded and treated as a linear function. There are suggestions that a sigmoidal relationship with definite upper and lower limits to leaf unfolding and flowering onset dates might be more realistic. We utilised European plant phenological records provided by the European phenology database PEP725 and gridded monthly mean temperature data for 1951-2012 calculated from the ENSEMBLES data set E-OBS (version 7.0). We analysed 568,456 observations of ten spring flowering or leafing phenophases derived from 3657 stations in 22 European countries in order to detect possible nonlinear responses to temperature. Linear response rates averaged for all stations ranged between -7.7 (flowering of hazel) and -2.7 days °C -1 (leaf unfolding of beech and oak). A lower sensitivity at the cooler end of the temperature range was detected for most phenophases. However, a similar lower sensitivity at the warmer end was not that evident. For only ∼14 % of the station time series (where a comparison between linear and nonlinear model was possible), nonlinear models described the relationship significantly better than linear models. Although in most cases simple linear models might be still sufficient to predict future changes, this linear relationship between phenology and temperature might not be appropriate when incorporating phenological data of very cold (and possibly very warm) environments. For these cases, extrapolations on the basis of linear models would introduce uncertainty in expected ecosystem changes.

Can we detect a nonlinear response to temperature in European plant phenology?

NASA Astrophysics Data System (ADS)

Jochner, Susanne; Sparks, Tim H.; Laube, Julia; Menzel, Annette

2016-10-01

Over a large temperature range, the statistical association between spring phenology and temperature is often regarded and treated as a linear function. There are suggestions that a sigmoidal relationship with definite upper and lower limits to leaf unfolding and flowering onset dates might be more realistic. We utilised European plant phenological records provided by the European phenology database PEP725 and gridded monthly mean temperature data for 1951-2012 calculated from the ENSEMBLES data set E-OBS (version 7.0). We analysed 568,456 observations of ten spring flowering or leafing phenophases derived from 3657 stations in 22 European countries in order to detect possible nonlinear responses to temperature. Linear response rates averaged for all stations ranged between -7.7 (flowering of hazel) and -2.7 days °C-1 (leaf unfolding of beech and oak). A lower sensitivity at the cooler end of the temperature range was detected for most phenophases. However, a similar lower sensitivity at the warmer end was not that evident. For only ˜14 % of the station time series (where a comparison between linear and nonlinear model was possible), nonlinear models described the relationship significantly better than linear models. Although in most cases simple linear models might be still sufficient to predict future changes, this linear relationship between phenology and temperature might not be appropriate when incorporating phenological data of very cold (and possibly very warm) environments. For these cases, extrapolations on the basis of linear models would introduce uncertainty in expected ecosystem changes.

Preparing Student Teachers to Address Complex Learning and Controversy with Middle Grades Students

ERIC Educational Resources Information Center

Smith, Ann Marie; Lennon, Sean

2011-01-01

This qualitative study explores pre-service teachers' perceptions of teaching critical literacy through discussions of controversial issues. Personality questionnaires were given to six classes of pre-student teachers over three semesters in order to gauge interest in teaching methods that incorporate inquiry learning and critical literacy. The…

The effect of falsely balanced reporting of the autism-vaccine controversy on vaccine safety perceptions and behavioral intentions.

PubMed

Dixon, Graham; Clarke, Christopher

2013-04-01

Controversy surrounding an autism-vaccine link has elicited considerable news media attention. Despite being widely discredited, research suggests that journalists report this controversy by presenting claims both for and against a link in a relatively 'balanced' fashion. To investigate how this reporting style influences judgments of vaccine risk, we randomly assigned 320 undergraduate participants to read a news article presenting either claims both for/against an autism-vaccine link, link claims only, no-link claims only or non-health-related information. Participants who read the balanced article were less certain that vaccines are safe, more likely to believe experts were less certain that vaccines are safe and less likely to have their future children vaccinated. Results suggest that balancing conflicting views of the autism-vaccine controversy may lead readers to erroneously infer the state of expert knowledge regarding vaccine safety and negatively impact vaccine intentions.

Video-game epilepsy: a European study.

PubMed

Kasteleijn-Nolst Trenité, D G; da Silva, A M; Ricci, S; Binnie, C D; Rubboli, G; Tassinari, C A; Segers, J P

1999-01-01

With the introduction of Nintendo video-games on a large scale, reports of children having seizures while playing suggested a possible specific, provocative factor. Although 50% of the photosensitive patients are also sensitive to a 50-Hz television, nonphotosensitive patients with a history of video-game seizures were described as well. The question arises whether this is a mere coincidence, provoked by fatigue and stress, is related to the reaction to the television screen itself, or depends on the movement and color of the pictures of this specific game. A European study was performed in four countries and five sites. All patients were selected because of a history of television, video- or computer-game seizures, with a history of sun-light-, discotheque-, or black and white pattern-evoked seizures, or were already known to be sensitive to intermittent photic stimulation. A total of 387 patients were investigated; 220 (75%) were female and 214 (55%) of those were < 18 years of age. After a routine examination, intermittent photic, pattern, and television stimulation were performed in a standardized way. The patients were investigated with Super Mario World and a standard relatively nonprovocative TV program, both on a 50- and 100-Hz television. Regardless of the distance, Super Mario World proved to be more provocative than the standard program (Wilcoxon, p < 0.05). Eighty-five percent showed epileptiform discharges evoked by intermittent photic stimulation. Forty-five percent of patients were 50-Hz television sensitive and 26% were 100-Hz television sensitive. Pattern sensitivity was found in 28% of patients. The patients, referred because of a television, video- or computer-game seizure, were significantly more sensitive to pattern and to the 50-Hz television (chi square, p < 0.001). More patients are sensitive when playing Super Mario, compared with the standard program (Wilcoxon, p = 0.001) and more sensitive with playing versus viewing (p = 0.016). Of the

Oxygen-sensitive potassium channels in chemoreceptor cell physiology: making a virtue of necessity.

PubMed

Gonzalez, Constancio; Vaquero, Luis M; López-López, José Ramón; Pérez-García, M Teresa

2009-10-01

The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygen-sensitive K(+) channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O(2) sensors to O(2)-sensitive ion channels, have been found. Although the endpoints of the process are analogous, the heterogeneity of the elements involved in the different chemoreceptor tissues precludes a unifying theory of hypoxic signaling, and it has been a source of controversy. However, when these molecular constituents of the hypoxic cascade are brought back to their physiological context, it becomes clear that the diversity of mechanisms is necessary to build up an integrated cellular response that demands the concerted action of several O(2) sensors and several effectors.

Autism Narratives in Media Coverage of the MMR Vaccine-Autism Controversy under a Crip Futurism Framework.

PubMed

Mann, Benjamin W

2018-03-09

While previous studies in health communication have examined online news media regarding autism, there is a lack of research that critically examines how such media representations may stigmatize autism and seeks to eliminate the condition, particularly in the context of the resurging measles, mumps, and rubella (MMR) vaccine-autism controversy. To address this gap in the literature, this study analyzes 153 articles that engage the MMR vaccine-autism controversy from the top 10 online news sources in the U.S. from September 2015 through July 2017. It draws from Kafer's (2013) work in Feminist, Crip, Queer, using a lens of crip futurism to interpret three major narrative themes: a death and survival narrative that purports autism as a worst-case scenario, a societal problem narrative, and a preventative narrative that seeks to eliminate the condition. These themes suggest that online news media narratives about autism surrounding the autism-MMR controversy play into stereotypes about autism, including stigmatization and prioritization of preventive behaviors and cures over supporting the lived experiences of autistic individuals. Continued research on the impact of online media portrayals of autism specifically, and disability in health contexts generally, is called for.

A European perspective--the European clinical research infrastructures network.

PubMed

Demotes-Mainard, J; Kubiak, C

2011-11-01

Evaluating research outcomes requires multinational cooperation in clinical research for optimization of treatment strategies and comparative effectiveness research, leading to evidence-based practice and healthcare cost containment. The European Clinical Research Infrastructures Network (ECRIN) is a distributed ESFRI (European Strategy Forum on Research Infrastructures) roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients, and unlocking latent scientific potential. Servicing multinational trials started during its preparatory phase, and ECRIN will now apply for an ERIC (European Research Infrastructures Consortium) status by 2011. By creating a single area for clinical research in Europe, this achievement will contribute to the implementation of the Europe flagship initiative 2020 'Innovation Union', whose objectives include defragmentation of the research and education capacity, tackling the major societal challenges starting with the area of healthy ageing, and removing barriers to bring ideas to the market.

Herpes Zoster Vaccination: Controversies and Common Clinical Questions.

PubMed

Van Epps, Puja; Schmader, Kenneth E; Canaday, David H

2016-01-01

Herpes zoster, clinically referred to as shingles, is an acute, cutaneous viral infection caused by reactivation of the varicella zoster virus, the same virus that causes chickenpox. The incidence of herpes zoster and its complications increase with decline in cell-mediated immunity, including age-associated decline. The most effective management strategy for herpes zoster is prevention of the disease through vaccination in those who are most vulnerable. Despite the demonstrated efficacy in reducing the incidence and severity of herpes zoster, the uptake of vaccine remains low. Here, we will discuss the controversies that surround the live herpes zoster vaccine and address the common clinical questions that arise. We will also discuss the new adjuvanted herpes zoster vaccine currently under investigation. © 2015 S. Karger AG, Basel.

Cigarette smoking and lung cancer: a continuing controversy.

PubMed

Burch, P R

1982-09-01

During the late 1950s Sir Ronald Fisher questioned the already popular, but in his view precipitate, causal interpretation of the association between smoking and lung cancer. His pungently expressed views began a controversy that has smouldered and sometimes flared ever since. The most recent attack on Fisher's constitutional hypothesis was launched by Reif and in this paper I consider the validity of his criticisms. A range of evidence shows that it is not yet possible to distinguish between constitutional and causal-plus-constitutional interpretations although recent studies indicate that a pure causal hypothesis is incapable of explaining the full association as observed in Western populations. Unfortunately, errors of diagnosis and death certification still impede the rigorous testing of adequately formulated hypotheses.

Promoting the Role of the Personal Narrative in Teaching Controversial Socio-Scientific Issues

ERIC Educational Resources Information Center

Levinson, Ralph

2008-01-01

Citizens participating in contemporary socio-scientific issues (SSI) need to draw on local knowledge and personal experience. If curricular developments in the teaching of controversial SSI are to reflect contemporary notions of citizenship then the personal narrative is an indispensable instrument in bridging the gap between the local/personal…

Old and New Controversies in the Alternative Treatment of Attention-Deficit Hyperactivity Disorder

ERIC Educational Resources Information Center

Rojas, Neal L.; Chan, Eugenia

2005-01-01

Use of complementary and alternative medicine (CAM) for treatment of attention-deficit hyperactivity disorder (ADHD) has become widespread in both referral and primary care populations. We review the purported mechanism of action and available evidence for selected CAM therapies for ADHD. Enduring controversies, such as elimination of artificial…

The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP)--a sentinel approach in the European Union (EU)/European Economic Area (EEA).

PubMed

Spiteri, Gianfranco; Cole, Michelle; Unemo, Magnus; Hoffmann, Steen; Ison, Catherine; van de Laar, Marita

2013-12-01

Antimicrobial resistance in Neisseria gonorrhoeae is monitored in the European Union/European Economic Area through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) coordinated by the European Centre for Disease Prevention and Control. Euro-GASP includes a sentinel surveillance programme which aims to detect in a timely manner changes in resistance patterns and inform treatment guidelines. The programme aims to test a representative number of isolates from each European Union/European Economic Area member state per year for a range of therapeutically relevant antimicrobials through a biannual hybrid centralised/decentralised system. Testing is supported by an External Quality Assurance programme and a laboratory training programme. Participation in the programme has increased to 21 countries in 2012. Euro-GASP has been able to detect the rapid spread of isolates with decreased susceptibility to cefixime across Europe in 2010 and 2011. Results from the programme have informed changes in European treatment guidelines for gonorrhoea and led to the development of the 'Response plan to control and manage the threat of multidrug resistant gonorrhoea in Europe'. Future challenges for Euro-GASP include supporting countries to participate in Euro-GASP through decentralised testing, improving timeliness and epidemiological data quality, and increasing participation from Eastern Europe.

Ethnic differences in physical pain sensitivity: role of acculturation.

PubMed

Chan, Michelle Y P; Hamamura, Takeshi; Janschewitz, Kristin

2013-01-01

Although research suggests that Asian Americans are more reactive to physical pain than European Americans, some evidence suggests that the observed differences in ethnicity may actually reflect Asian Americans' differing levels of acculturation. Two studies were conducted to test this hypothesis. In Study 1, first- and second-generation Asian Americans and European Americans took part in a cold pressor task. Evidence of heightened pain responses was found only among first-generation Asian Americans. Study 2 further controlled for ethnicity and replicated this pattern in finding heightened pain reactions among mainland Chinese students in Hong Kong relative to Hong Kong Chinese students. These findings suggest a role for acculturation in accounting for ethnic differences in physical pain sensitivity. Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

The "Magic Cure" A Review of the Current Controversial Approaches for Treating Learning Disabilities.

ERIC Educational Resources Information Center

Silver, Larry B.

1987-01-01

In view of popular press coverage of controversial approaches to treating learning disabilities, the article briefly reviews evidence concerning the following: neurophysiological retraining (patterning, optometric visual training, cerebellar-vestibular remediation, and applied kinesiology); and orthomolecular medicine (concerning megavitamins,…

Increased sensitivity to climate change in disturbed ecosystems.

PubMed

Kröel-Dulay, György; Ransijn, Johannes; Schmidt, Inger Kappel; Beier, Claus; De Angelis, Paolo; de Dato, Giovanbattista; Dukes, Jeffrey S; Emmett, Bridget; Estiarte, Marc; Garadnai, János; Kongstad, Jane; Kovács-Láng, Edit; Larsen, Klaus Steenberg; Liberati, Dario; Ogaya, Romà; Riis-Nielsen, Torben; Smith, Andrew R; Sowerby, Alwyn; Tietema, Albert; Penuelas, Josep

2015-03-24

Human domination of the biosphere includes changes to disturbance regimes, which push many ecosystems towards early-successional states. Ecological theory predicts that early-successional ecosystems are more sensitive to perturbations than mature systems, but little evidence supports this relationship for the perturbation of climate change. Here we show that vegetation (abundance, species richness and species composition) across seven European shrublands is quite resistant to moderate experimental warming and drought, and responsiveness is associated with the dynamic state of the ecosystem, with recently disturbed sites responding to treatments. Furthermore, most of these responses are not rapid (2-5 years) but emerge over a longer term (7-14 years). These results suggest that successional state influences the sensitivity of ecosystems to climate change, and that ecosystems recovering from disturbances may be sensitive to even modest climatic changes. A research bias towards undisturbed ecosystems might thus lead to an underestimation of the impacts of climate change.

Standard skin prick testing and sensitization to inhalant allergens across Europe--a survey from the GALEN network.

PubMed

Heinzerling, L; Frew, A J; Bindslev-Jensen, C; Bonini, S; Bousquet, J; Bresciani, M; Carlsen, K-H; van Cauwenberge, P; Darsow, U; Fokkens, W J; Haahtela, T; van Hoecke, H; Jessberger, B; Kowalski, M L; Kopp, T; Lahoz, C N; Lodrup Carlsen, K C; Papadopoulos, N G; Ring, J; Schmid-Grendelmeier, P; Vignola, A M; Wöhrl, S; Zuberbier, T

2005-10-01

Skin prick testing (SPT) is the standard method for diagnosing allergic sensitization but is to some extent performed differently in clinical centres across Europe. There would be advantages in harmonizing the standard panels of allergens used in different European countries, both for clinical purposes and for research, especially with increasing mobility within Europe and current trends in botany and agriculture. As well as improving diagnostic accuracy, this would allow better comparison of research findings in European allergy centres. We have compared the different SPT procedures operating in 29 allergy centres within the Global Allergy and Asthma European Network (GA(2)LEN). Standard SPT is performed similarly in all centres, e.g. using commercial extracts, evaluation after 15-20 min exposure with positive results defined as a wheal >3 mm diameter. The perennial allergens included in the standard SPT panel of inhalant allergens are largely similar (e.g. cat: pricked in all centres; dog: 26 of 29 centres and Dermatophagoides pteronyssinus: 28 of 29 centres) but the choice of pollen allergens vary considerably, reflecting different exposure and sensitization rates for regional inhalant allergens. This overview may serve as reference for the practising doctor and suggests a GA(2)LEN Pan-European core SPT panel.

Systematic review on the evaluation criteria of orphan medicines in Central and Eastern European countries.

PubMed

Zelei, Tamás; Molnár, Mária J; Szegedi, Márta; Kaló, Zoltán

2016-06-04

In case of orphan drugs applicability of the standard health technology assessment (HTA) process is limited due to scarcity of good clinical and health economic evidence. Financing these premium priced drugs is more controversial in the Central and Eastern European (CEE) region where the public funding resources are more restricted, and health economic justification should be an even more important aspect of policy decisions than in higher income European countries. To explore and summarize the recent scientific evidence on value drivers related to the health technology assessment of ODs with a special focus on the perspective of third party payers in CEE countries. The review aims to list all potentially relevant value drivers in the reimbursement process of orphan drugs. A systematic literature review was performed; PubMed and Scopus databases were systematically searched for relevant publications until April 2015. Extracted data were summarized along key HTA elements. From the 2664 identified publications, 87 contained relevant information on the evaluation criteria of orphan drugs, but only 5 had direct information from the CEE region. The presentation of good clinical evidence seems to play a key role especially since this should be the basis of cost-effectiveness analyses, which have more importance in resource-constrained economies. Due to external price referencing of pharmaceuticals, the relative budget impact of orphan drugs is expected to be higher in CEE than in Western European (WE) countries unless accessibility of patients remains more limited in poorer European regions. Equity principles based on disease prevalence and non-availability of alternative treatment options may increase the price premium, however, societies must have some control on prices and a rationale based on multiple criteria in reimbursement decisions. The evaluation of orphan medicines should include multiple criteria to appropriately measure the clinical added value of orphan

An analysis of European shale gas policies: Why EU member states are pursuing divergent 'fracking' strategies

NASA Astrophysics Data System (ADS)

Thorne, Ben

The recent progression in hydraulic fracturing or 'fracking' has enabled energy companies to extract once-considered, inaccessible hydrocarbons. The United States has been at the forefront of this controversial industry, revolutionizing the energy market by becoming the world's largest oil and natural gas producer as a result of its vast shale deposits. Shale oil and gas deposits are not unique to North America, however. EU member states are faced with the dilemma of whether to permit fracking domestically or suspend operations. The United Kingdom and Romania have issued concessions for exploring their reserves, while France and Bulgaria have halted all drilling efforts, citing environmental concerns. This paper evaluates why these four European countries pursued divergent fracking policies, arguing that energy security and Russian-relations are more relevant and powerful explanatory factors than a country's commitment to protecting the environment.

Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies.

PubMed

Dessinioti, Clio; Katsambas, Andreas

2013-01-01

Seborrheic dermatitis (SD) is a common skin condition seen frequently in clinical practice. The use of varying terms such as sebopsoriasis, seborrheic dermatitis, seborrheic eczema, dandruff, and pityriasis capitis reflects the complex nature of this condition. Despite its frequency, much controversy remains regarding the pathogenesis of SD. This controversy extends to its classification in the spectrum of cutaneous diseases, having being classified as a form of dermatitis, a fungal disease, or an inflammatory disease, closely related with psoriasis. Some have postulated that SD is caused by Malassezia yeasts, based on the observation of their presence in affected skin and the therapeutic response to antifungal agents. Others have proposed that Malassezia is incidental to a primary inflammatory dermatosis that resulted in increased cell turnover, scaling, and inflammation in the epidermis, similar to psoriasis. The presence of host susceptibility factors, permitting the transition of M furfur to its pathogenic form, may be associated with immune response and inflammation. Metabolites produced by Malassezia species, including oleic acid, malssezin, and indole-3-carbaldehyde, have been implicated. SD also has been traditionally considered to be a form of dermatitis based on the presence of Malassezia in healthy skin, the absence the pathogenic mycelial form of Malassezia yeasts in SD, and its chronic course. As a result, proposed treatments vary, ranging from topical corticosteroids to topical antifungals and antimicrobial peptides. Copyright © 2013 Elsevier Inc. All rights reserved.

Experimental studies on the nature of sensitive skin.

PubMed

Kligman, A M; Sadiq, Iqbal; Zhen, Yaxian; Crosby, Marilyn

2006-11-01

In the USA, Europe and Japan 40 to 50% of women report that they have sensitive skin, defined as abnormal sub-clinical sensory responses to drugs, cosmetics and toiletries in the absence of visible signs of irritation. Itching, burning, stinging and tightness are the commonest complaints, which mainly afflict women. Manufacturers of skin care products have made available a large variety of products which are designed for persons with sensitive skin. Such products are not required by regulatory agencies to submit evidence of safety and efficacy, allowing marketers to make claims that are often exaggerated, irrational and even preposterous. The consumer with self-assessed sensitive skin has no way of judging which products are likely to be most beneficial and least harmful. The marketplace is awash with products for which there is no evidence that the rosy claims have been substantiated by appropriate testing procedures. There is no internationally accepted consensus regarding the criteria which define sensitive skin. Many papers have been published in the last 15 years, mainly originating from industry, which express widely differing views regarding what constitutes sensitive skin. For some, any adverse reaction to a product topically applied to sensitive skin, including breakouts, redness, scaling etc., a panoply of adverse reactions which is virtually meaningless. Others include environmental factors as causative, including cold, dry wind, heat and high humidity, solar radiation, etc., which add to the manifest complexities of the subject. This is the first paper in a series which provides a comprehensive review of the subject, emphasizing the all too many controversies and confusions arising from the lack of a consensus regarding the identification, classification, epidemiology, prevalence and pathogenesis of sensitive skin. Sensitive skin is a biologic reality and not a psychological, fashionable fantasy on the part of impressionable women. There is an urgent

Ethical Considerations for Psychologists Taking a Public Stance on Controversial Issues: The Balance Between Personal and Professional Life

PubMed Central

Haeny, Angela M.

2014-01-01

Previous literature has documented the general issues psychologists often face while balancing their personal and professional lives. The struggle stems from attempting to satisfy the need to maintain a life outside of work while having the professional obligation to follow the American Psychological Association’s (APA’s) Ethical Principles of Psychologists and Code of Conduct (Ethics Code) to prevent their personal lives from interfering with their professional roles and relationships. The present paper analyzes the subject of psychologists taking a public position on controversial public issues. Although the APA Ethics Code does not restrict how psychologists conduct themselves during their personal time, taking a public stance on a controversial issue could potentially strain professional relationships and inadvertently reflect negatively on the profession. The present paper examines ethical issues that a) should be taken into account before psychologists take a public position on a controversial issue, and b) are in conflict with APA’s Ethics Code or current research. PMID:25342876

Ethical Considerations for Psychologists Taking a Public Stance on Controversial Issues: The Balance Between Personal and Professional Life.

PubMed

Haeny, Angela M

2014-07-01

Previous literature has documented the general issues psychologists often face while balancing their personal and professional lives. The struggle stems from attempting to satisfy the need to maintain a life outside of work while having the professional obligation to follow the American Psychological Association's (APA's) Ethical Principles of Psychologists and Code of Conduct (Ethics Code) to prevent their personal lives from interfering with their professional roles and relationships. The present paper analyzes the subject of psychologists taking a public position on controversial public issues. Although the APA Ethics Code does not restrict how psychologists conduct themselves during their personal time, taking a public stance on a controversial issue could potentially strain professional relationships and inadvertently reflect negatively on the profession. The present paper examines ethical issues that a) should be taken into account before psychologists take a public position on a controversial issue, and b) are in conflict with APA's Ethics Code or current research.

Breast cancer screening controversies: who, when, why, and how?

PubMed

Chetlen, Alison; Mack, Julie; Chan, Tiffany

2016-01-01

Mammographic screening is effective in reducing mortality from breast cancer. The issue is not whether mammography is effective, but whether the false positive rate and false negative rates can be reduced. This review will discuss controversies including the reduction in breast cancer mortality, overdiagnosis, the ideal screening candidate, and the optimal imaging modality for breast cancer screening. The article will compare and contrast screening mammography, tomosynthesis, whole-breast screening ultrasound, magnetic resonance imaging, and molecular breast imaging. Though supplemental imaging modalities are being utilized to improve breast cancer diagnosis, mammography still remains the gold standard for breast cancer screening. Copyright © 2015 Elsevier Inc. All rights reserved.

[Sampling in qualitative research: basic principles and some controversies].

PubMed

Martínez-Salgado, Carolina

2012-03-01

This paper presents the rationale for the choice of participants in qualitative research in contrast with that of probability sampling principles in epidemiological research. For a better understanding of the differences, concepts of nomothetic and ideographic generalizability, as well as those of transferability and reflexivity, are proposed, Fundamentals of the main types of sampling commonly used in qualitative research, and the meaning of the concept of saturation are mentioned. Finally, some reflections on the controversies that have arisen in recent years on various paradigmatic perspectives from which to conduct qualitative research, their possibilities of combination with epidemiological research, and some implications for the study of health issues are presented.

The Oil Drop Experiment: Do Physical Chemistry Textbooks Refer to Its Controversial Nature?

ERIC Educational Resources Information Center

Niaz, Mansoor; Rodriguez, Maria A.

2005-01-01

Most general chemistry textbooks consider the oil drop experiment as a classic experiment, characterized by its simplicity and precise results. A review of the history and philosophy of science literature shows that the experiment is difficult to perform (even today!) and generated a considerable amount of controversy. Acceptance of the…

The European Location Framework - from National to European

NASA Astrophysics Data System (ADS)

Pauknerova, E.; Sidlichovsky, P.; Urbanas, S.; Med, M.

2016-06-01

The European Location Framework (ELF) means a technical infrastructure which will deliver authoritative, interoperable geospatial reference data from all over Europe for analysing and understanding information connected to places and features. The ELF has been developed and set up through the ELF Project, which has been realized by a consortium of partners (public, private and academic organisations) since March 2013. Their number increased from thirty to forty in the year 2016, together with a project extension from 36 to 44 months. The project is co-funded by the European Commission's Competitiveness and Innovation Framework Programme (CIP) and will end in October 2016. In broad terms, the ELF Project will deliver a unique gateway to the authoritative reference geospatial information for Europe (harmonised pan-European maps, geographic and land information) sourced from the National Mapping and Cadastral Authorities (NMCAs) around Europe and including transparent licensing. This will be provided as an online ELF web service that will deliver an up-to-date topographic base map and also as view & download services for access to the ELF datasets. To develop and build up the ELF, NMCAs are accompanied and collaborate with several research & academia institutes, a standardisation body, system integrators, software developers and application providers. The harmonisation is in progress developing and triggering a number of geo-tools like edge-matching, generalisation, transformation and others. ELF will provide also some centralised tools like Geo Locator for searching location based on geographical names, addresses and administrative units, and GeoProduct Finder for discovering the available web-services and licensing them. ELF combines national reference geo-information through the ELF platform. ELF web services will be offered to users and application developers through open source (OSKARI) and proprietary (ArcGIS Online) cloud platforms. Recently, 29 NMCAs plus the

Controversy about Management of Hydrocephalus - Shunt vs. Endoscopic Third Ventriculostomy.

PubMed

Kumar, Vikas; Bodeliwala, Shaam; Singh, Daljit

2017-08-01

The best management of hydrocephalus is still controversial in the twenty-first century. Shunt treatment for hydrocephalus is the most common procedure performed in neurosurgical practice and is associated with the highest complications rate. But during the last 2 decades, the treatment of hydrocephalus has improved with better shunt devices available today, increased facilities for investigations and newer approaches like endoscopic third ventriculostomy. The recent advances in development of better endoscopes have provided the patient and treating doctor with an option for an alternative surgery for treatment of hydrocephalus.

Everything you need to know to understand the current controversies you learned from psychological research. A comment on the Rind and Lilienfeld controversies.

PubMed

Sternberg, Robert J

2002-03-01

Psychological theory and research can help explain some of the aspects of the controversies that arose over articles written by B. Rind, P. Tromovitch, and R. Bauserman (1998) and by S. O. Lilienfeld (2002). In particular, one needs to distinguish between rational and intuitive thinking, to recognize the power of context, to be reflective in one's own thinking, and to realize the costs of defying the crowd. There are steps one can take to be wiser and more balanced in one's own thinking than one may have been in the past. One such step is to resolve conflicts among psychologists by attempting to defuse rather than to exacerbate or avoid them.

Framing effectiveness in impact assessment: Discourse accommodation in controversial infrastructure development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rozema, Jaap G., E-mail: j.rozema@uea.ac.uk; Department of Development and Planning, Aalborg University, A.C. Meyers Vænge 15, DK-2450 København SV; Bond, Alan J.

There is ongoing debate about the effectiveness of impact assessment tools, which matters both because of the threat to future practice of the tools which are frequently perceived to be ineffective, and because of the disillusionment that can ensue, and controversy generated, amongst stakeholders in a decision context where opportunities for meaningful debate have not been provided. In this article we regard debate about the meaning of effectiveness in impact assessment as an inevitable consequence of increased participation in environmental decision-making, and therefore frame effectiveness based on an inclusive democracy role to mean the extent to which impact assessment canmore » accommodate civil society discourse. Our aim is to investigate effectiveness based on this framing by looking at one type of impact assessment – environmental impact assessment (EIA) – in two controversial project proposals: the HS2 rail network in England; and the A4DS motorway in the Netherlands. Documentary analysis and interviews held with key civil society stakeholders have been deployed to identify discourses that were mobilised in the cases. EIA was found to be able to accommodate only one out of four discourses that were identified; for the other three it did not provide the space for the arguments that characterised opposition. The conclusion in relation to debate on framings of effectiveness is that EIA will not be considered effective by the majority of stakeholders. EIA was established to support decision-making through a better understanding of impacts, so its ineffectiveness is unsurprising when its role is perceived to be broader. However, there remains a need to map discourses in different decision contexts and to analyse the extent to which the range of discourses are accommodated throughout the decision process, and the role of impact assessment in those processes, before recommendations can be made to either improve impact assessment effectiveness, or whether it

Academic Controversy in Macroeconomics: An Active and Collaborative Method to Increase Student Learning

ERIC Educational Resources Information Center

Santicola, Craig F.

2015-01-01

The literature indicates that there is a lack of learning outcomes in economics that can be attributed to the reliance on traditional lecture and the failure to adopt innovative instructional techniques. This study sought to investigate the student learning effects of academic controversy, a cooperative learning technique that shows promise in the…

College Board Delegates Argue Controversies of the Day: Productivity and Paying for College.

ERIC Educational Resources Information Center

Evangelauf, Jean

1987-01-01

The annual meeting of the College Board focused on some of the most controversial issues facing higher education including: productivity, accountability, prepaid tuition plans, Guaranteed Student Loan (GSL) program, and one alternative to the G.S.L.--students could borrow from the government and then pay a higher Social Security tax. (MLW)

Creating a Controversial Picturebook: Discussions with the Creators of "And Tango Makes Three"

ERIC Educational Resources Information Center

Young, Craig A.

2011-01-01

Censorship is not a new phenomenon in the field of children's literature. Children's and young adult books are often scrutinized for text and illustrations that may be found questionable for use with young readers. If deemed inappropriate, these books become the subjects of controversial debate and may fall victim to censorship. Although numerous…

Controversies in the Classroom: A Radical Teacher Reader. Teaching for Social Justice Series

ERIC Educational Resources Information Center

Entin, Joseph, Ed.; Rosen, Robert C., Ed.; Vogt, Leonard, Ed.

2008-01-01

"Controversies in the Classroom" features the most important and exciting writing from the past 15 years of "Radical Teacher" magazine. This is a must-read for all teachers who are committed to creative pedagogy and social justice. Contributors include: Bernadette Anand, Nancy Barnes, Lilia I. Bartolome, Bill Bigelow, Lawrence Blum, Marjorie Feld,…

Honoring Controversy: Using Real-World Problems to Teach Critical Thinking in Honors Courses

ERIC Educational Resources Information Center

Cargas, Sarita

2016-01-01

In this article Sarita Cargas suggests that getting honors students used to analyzing controversies will contribute to their developing a disposition toward critical thinking. She goes on to say that the value of teaching critical-thinking skills complements the movement of many honors programs toward teaching more than just disciplinary content.…

The European Marine Strategy: Noise Monitoring in European Marine Waters from 2014.

PubMed

Dekeling, René; Tasker, Mark; Ainslie, Michael; Andersson, Mathias; André, Michel; Borsani, Fabrizio; Brensing, Karsten; Castellote, Manuel; Dalen, John; Folegot, Thomas; van der Graaf, Sandra; Leaper, Russell; Liebschner, Alexander; Pajala, Jukka; Robinson, Stephen; Sigray, Peter; Sutton, Gerry; Thomsen, Frank; Werner, Stefanie; Wittekind, Dietrich; Young, John V

2016-01-01

The European Marine Strategy Framework Directive requires European member states to develop strategies for their marine waters leading to programs of measures that achieve or maintain good environmental status (GES) in all European seas by 2020. An essential step toward reaching GES is the establishment of monitoring programs, enabling the state of marine waters to be assessed on a regular basis. A register for impulsive noise-generating activities would enable assessment of their cumulative impacts on wide temporal and spatial scales; monitoring of ambient noise would provide essential insight into current levels and any trend in European waters.

Societal acceptance of controversial facilities: The role of two public participation strategies---negotiation and risk communication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolfe, A.K.

Public participation in decision making about the siting of controversial facilities is viewed in contradictory ways by different groups of people. Some see public participation as an impediment, while others think it is an important mechanism in gaining societal acceptance for eventual siting. This paper discusses two strategies for obtaining societal acceptance--- negotiation and risk communication---in light of the extent to which they (1) involve members of the public; (2) focus on risk-related issues; and (3) contribute to decisions to site controversial facilities. The paper presents an integrated conceptual model for public participation in siting decisions that incorporates risk asmore » well as social, political, and historical contexts. 20 refs., 1 fig.« less

Epistemological depth in a GM crops controversy.

PubMed

Hicks, Daniel J

2015-04-01

This paper examines the scientific controversy over the yields of genetically modified [GM] crops as a case study in epistemologically deep disagreements. Appeals to "the evidence" are inadequate to resolve such disagreements; not because the interlocutors have radically different metaphysical views (as in cases of incommensurability), but instead because they assume rival epistemological frameworks and so have incompatible views about what kinds of research methods and claims count as evidence. Specifically, I show that, in the yield debate, proponents and opponents of GM crops cite two different sets of claims as evidence, which correspond to two rival epistemological frameworks, classical experimental epistemology and Nancy Cartwright's evidence for use. I go on to argue that, even if both sides of the debate accepted Cartwright's view, they might still disagree over what counts as evidence, because evidence for use ties standards of evidence to what is sometimes called the "context of application." Copyright © 2015 Elsevier Ltd. All rights reserved.

Abdominal Aortic Aneurysm: Evolving Controversies and Uncertainties.

PubMed

Carino, Davide; Sarac, Timur P; Ziganshin, Bulat A; Elefteriades, John A

2018-06-01

Abdominal aortic aneurysm (AAA) is defined as a permanent dilatation of the abdominal aorta that exceeds 3 cm. Most AAAs arise in the portion of abdominal aorta distal to the renal arteries and are defined as infrarenal. Most AAAs are totally asymptomatic until catastrophic rupture. The strongest predictor of AAA rupture is the diameter. Surgery is indicated to prevent rupture when the risk of rupture exceeds the risk of surgery. In this review, we aim to analyze this disease comprehensively, starting from an epidemiological perspective, exploring etiology and pathophysiology, and concluding with surgical controversies. We will pursue these goals by addressing eight specific questions regarding AAA: (1) Is the incidence of AAA increasing? (2) Are ultrasound screening programs for AAA effective? (3) What causes AAA: Genes versus environment? (4) Animal models: Are they really relevant? (5) What pathophysiology leads to AAA? (6) Indications for AAA surgery: Are surgeons over-eager to operate? (7) Elective AAA repair: Open or endovascular? (8) Emergency AAA repair: Open or endovascular?

Unicameral bone cysts: general characteristics and management controversies.

PubMed

Pretell-Mazzini, Juan; Murphy, Robert Francis; Kushare, Indranil; Dormans, John P

2014-05-01

Unicameral bone cysts are benign bone lesions that are often asymptomatic and commonly develop in the proximal humerus and femur of skeletally immature patients. The etiology of these lesions remains unknown. Most patients present with a pathologic fracture, but these cysts can be discovered incidentally, as well. Radiographically, a unicameral bone cyst appears as a radiolucent lesion with cortical thinning and is centrally located within the metaphysis. Although diagnosis is frequently straightforward, management remains controversial. Because the results of various management methods are heterogeneous, no single method has emerged as the standard of care. New minimally invasive techniques involve cyst decompression with bone grafting and instrumentation. These techniques have yielded promising results, with low rates of complications and recurrence reported; however, prospective clinical trials are needed to compare these techniques with current evidence-based treatments.

Projecting Long-Term Care Expenditure in Four European Union Member States: The Influence of Demographic Scenarios

ERIC Educational Resources Information Center

Costa-Font, Joan; Wittenberg, Raphael; Patxot, Concepcio; Comas-Herrera, Adelina; Gori, Cristiano; di Maio, Alessandra; Pickard, Linda; Pozzi, Alessandro; Rothgang, Heinz

2008-01-01

This study examines the sensitivity of future long-term care demand and expenditure estimates to official demographic projections in four selected European countries: Germany, Spain, Italy and the United Kingdom. It uses standardised methodology in the form of a macro-simulation exercise and finds evidence for significant differences in…

Controversies in the association of cardiorespiratory fitness and arterial stiffness in children and adolescents.

PubMed

Meyer, Joanna; Elmenhorst, Julia; Giegerich, Tobias; Oberhoffer, Renate; Müller, Jan

2017-07-01

The relationship between cardiorespiratory fitness and arterial compliance in children and adolescents remains controversial. The aim of this study was to assess this association with a quantitative approach. A total of 646 healthy children and adolescents (316 females, age 13.9±2.1 years) were cross-sectionally investigated in seven school settings in and around Munich for their cardiorespiratory fitness and demographic, anthropometric and hemodynamic parameters. Surrogates of arterial stiffness, such as pulse wave velocity (PWV), Augmentation Index normalized to a heart rate of 75 (AI@75), and peripheral and central systolic blood pressures were measured in a supine position using the oscillometric Mobil-O-Graph. Cardiopulmonary fitness was measured by 6-min indoor run tests. After correction for age, sex, body weight, body height, heart rate and mean arterial pressure, controversial findings were produced. PWV increased with higher cardiorespiratory fitness (Beta=0.173; P<0.001), which represented an unfavorable relationship, whereas AI@75 declined with higher cardiorespiratory fitness (Beta=-0.106; P=0.025). Therefore, in contrast to PWV, higher cardiorespiratory fitness seems beneficial for AI@75. The third surrogate of arterial stiffness, central systolic blood pressure, showed no association with cardiorespiratory fitness (Beta=0.066; P=0.052). These controversial outcomes remain almost unchanged when the boys and girls were analyzed separately. Different surrogates of arterial stiffness have different relationships with cardiorespiratory fitness in children and adolescents after correcting for multiple confounders. More research is needed in this field to understand the functioning of the juvenile vessels, and measurements and methodological approaches should be reconsidered.

European Elder (Elderberry)

MedlinePlus

... Name: Sambucus nigra Background European elder is a tree native to Europe and parts of Asia and ... on European elder. Various parts of the elder tree, including the bark, leaves, flowers, fruits, and roots, ...

My Mother and Me: Why Tiger Mothers Motivate Asian Americans But Not European Americans.

PubMed

Fu, Alyssa S; Markus, Hazel Rose

2014-06-01

"Tiger Mother" Amy Chua provoked a culture clash with her claim that controlling parenting in Asian American (AA) contexts produces more successful children than permissive parenting in European American (EA) contexts. At the heart of this controversy is a difference in the normative models of self that guide behavior. Ideas and practices prevalent in AA contexts emphasize that the person is and should be interdependent with one's close others, especially one's mother. In contrast, EA contexts emphasize the person as independent, even from one's mother. We find that AA compared with EA high school students experience more interdependence with their mothers and pressure from them, but that the pressure does not strain their relationship with their mothers. Furthermore, following failure, AAs compared with EAs are more motivated by their mothers, and AAs are particularly motivated by pressure from their mothers when it conveys interdependence. © 2014 by the Society for Personality and Social Psychology, Inc.

Brokered dialogue: A new research method for controversial health and social issues.

PubMed

Parsons, Janet A; Lavery, James V

2012-07-02

Dialogue is a foundational feature of social life and an important way in which we come to understand one another. In situations of controversy dialogue is often absent because of a range of social barriers. We have developed a new film-based qualitative research method for studying controversial issues in healthcare and social policy. We call this method Brokered Dialogue. Theoretically informed by the traditions in narrative inquiry and visual anthropology, the method is premised on the idea that dialogue possesses features making it unique as a generator of new knowledge and opportunities for social intervention. Film is not only an extraordinarily rich data source, but an excellent medium for knowledge transfer and dissemination. The paper introduces the Brokered Dialogue method. We outline its critical steps, including the procedures for sampling, data collection and data analysis of both textual and visual data. Participants in a Brokered Dialogue engage in filmed interviews that capture their perspectives on a given topic; they then share their perspectives with, and pose questions of, one another through the medium of film. Using a participatory editing process, only footage that participants feel comfortable showing to others is incorporated. This technique offers participants a 'safe' space for respectful interaction. The editing process itself is analytic, and the final assembly of footage approximates a dialogue on the topic at hand. A link to a film produced from a project piloting the method is provided to demonstrate its real world application. Brokered Dialogue is a method for promoting respectful interactions among those with seemingly divergent views on a controversial topic and for discovering critical points of divergence that may represent pathways for improvement. While the end product is a 'film', the goal is to have these films used as catalysts for ongoing respectful dialogue and problem-solving concerning the topic at hand informing

Brokered dialogue: A new research method for controversial health and social issues

PubMed Central

2012-01-01

Abstract Background Dialogue is a foundational feature of social life and an important way in which we come to understand one another. In situations of controversy dialogue is often absent because of a range of social barriers. We have developed a new film-based qualitative research method for studying controversial issues in healthcare and social policy. We call this method Brokered Dialogue. Theoretically informed by the traditions in narrative inquiry and visual anthropology, the method is premised on the idea that dialogue possesses features making it unique as a generator of new knowledge and opportunities for social intervention. Film is not only an extraordinarily rich data source, but an excellent medium for knowledge transfer and dissemination. Discussion The paper introduces the Brokered Dialogue method. We outline its critical steps, including the procedures for sampling, data collection and data analysis of both textual and visual data. Participants in a Brokered Dialogue engage in filmed interviews that capture their perspectives on a given topic; they then share their perspectives with, and pose questions of, one another through the medium of film. Using a participatory editing process, only footage that participants feel comfortable showing to others is incorporated. This technique offers participants a ‘safe’ space for respectful interaction. The editing process itself is analytic, and the final assembly of footage approximates a dialogue on the topic at hand. A link to a film produced from a project piloting the method is provided to demonstrate its real world application. Summary Brokered Dialogue is a method for promoting respectful interactions among those with seemingly divergent views on a controversial topic and for discovering critical points of divergence that may represent pathways for improvement. While the end product is a ‘film’, the goal is to have these films used as catalysts for ongoing respectful dialogue and problem

Writing a Rationale for a Controversial Common Reading Book: Alice Walker's "The Color Purple."

ERIC Educational Resources Information Center

Worthington, Pepper

1985-01-01

Offers a rationale that can be used to defend the assignment of Alice Walker's controversial novel for class reading. Indicates four issues that might evoke calls for censorship: (1) subject matter, (2) vocabulary, (3) grammar, and (4) the epistolary form of the work. (RBW)

Lyme disease: diagnostic issues and controversies.

PubMed

Aguero-Rosenfeld, Maria E; Wormser, Gary P

2015-01-01

The diagnosis of Lyme disease is a controversial topic. Most practitioners and scientists recognize that Lyme disease is associated with certain objective clinical manifestations supported by laboratory evidence of infection with Borrelia burgdorferi sensu lato (the etiologic agent). There are others, however, who believe that patients with Lyme disease may have a wide variety of entirely nonspecific symptoms without any objective clinical manifestation and that laboratory evidence of infection by B. burgdorferi is not required to support the diagnosis. In reality, this perspective is not evidence based and would inevitably lead to innumerable misdiagnoses, given the high frequency of medically unexplained symptoms, such as fatigue and musculoskeletal pains, in the general population. Although those espousing this viewpoint do not believe that a positive laboratory test is required, nevertheless, they often seek out and promote alternative, unapproved testing methods that frequently provide false-positive results to justify their diagnosis. Herein, we provide a brief overview of Lyme disease testing, emphasizing current usage and limitations. We also discuss the use of nonvalidated procedures and the prospects for a reduction in such testing practices in the future.

Targeted Coagulation Management in Severe Trauma: The Controversies and the Evidence.

PubMed

Winearls, James; Reade, Michael; Miles, Helen; Bulmer, Andrew; Campbell, Don; Görlinger, Klaus; Fraser, John F

2016-10-01

Hemorrhage in the setting of severe trauma is a leading cause of death worldwide. The pathophysiology of hemorrhage and coagulopathy in severe trauma is complex and remains poorly understood. Most clinicians currently treating trauma patients acknowledge the presence of a coagulopathy unique to trauma patients-trauma-induced coagulopathy (TIC)-independently associated with increased mortality. The complexity and incomplete understanding of TIC has resulted in significant controversy regarding optimum management. Although the majority of trauma centers utilize fixed-ratio massive transfusion protocols in severe traumatic hemorrhage, a widely accepted "ideal" transfusion ratio of blood to blood products remains elusive. The recent use of viscoelastic hemostatic assays (VHAs) to guide blood product replacement has further provoked debate as to the optimum transfusion strategy. The use of VHA to quantify the functional contributions of individual components of the coagulation system may permit targeted treatment of TIC but remains controversial and is unlikely to demonstrate a mortality benefit in light of the heterogeneity of the trauma population. Thus, VHA-guided algorithms as an alternative to fixed product ratios in trauma are not universally accepted, and a hybrid strategy starting with fixed-ratio transfusion and incorporating VHA data as they become available is favored by some institutions. We review the current evidence for the management of coagulopathy in trauma, the rationale behind the use of targeted and fixed-ratio approaches and explore future directions.

Time trends of contact allergy to the European baseline series in Lithuania.

PubMed

Linauskienė, Kotryna; Malinauskienė, Laura; Blažienė, Audra

2017-06-01

Monitoring trends of positive patch test reactions is useful for epidemiological surveillance and contact allergy prevention, and has not previously been reported in Lithuania. To examine and compare changes in the prevalence of contact allergy to European baseline series allergens in adults with suspected contact dermatitis during a 9-year period. In this retrospective study, patch test results of 297 consecutive patients, tested with the European baseline series in 2014-2015, were analysed and compared with the data published earlier in Lithuania. The most common allergens were nickel sulfate (30.6%), methylisothiazolinone (MI) (13.5%), methylchloroisothiazolinone (MCI)/MI (7.4%), potassium dichromate (6.1%), cobalt chloride (6.1%), Myroxylon pereirae resin (5.4%), p-phenylenediamine (5.4%), fragrance mix I (4.7%), formaldehyde (4.4%), and methyldibromo glutaronitrile (3.7%). Increases in the prevalence of sensitization to MCI/MI (2.3% in 2006-2008 and 7.4% in 2014-2015; p < 0.0001) and nickel sulfate (16.4% in 2006-2008 and 30.6% in 2014-2015; p < 0.0001) and decreases in the prevalence of sensitization to paraben mix (3.2% in 2006-2008 and 0.3% in 2014-2015; p = 0.006) were observed. Prevalences for the other allergens remained stable or showed a decreasing trend (Myroxylon pereirae resin; p = 0.06). This study provides current information on the prevalence of contact allergy in Lithuania. Changing trends in sensitivity to some allergens probably reflect changes in exposure. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Mineral Metabolism in European Children Living with a Renal Transplant: A European Society for Paediatric Nephrology/European Renal Association–European Dialysis and Transplant Association Registry Study

PubMed Central

Bonthuis, Marjolein; Busutti, Marco; Jager, Kitty J.; Baiko, Sergey; Bakkaloğlu, Sevcan; Battelino, Nina; Gaydarova, Maria; Gianoglio, Bruno; Parvex, Paloma; Gomes, Clara; Heaf, James G.; Podracka, Ludmila; Kuzmanovska, Dafina; Molchanova, Maria S.; Pankratenko, Tatiana E.; Papachristou, Fotios; Reusz, György; Sanahuja, Maria José; Shroff, Rukshana; Groothoff, Jaap W.; Schaefer, Franz; Verrina, Enrico

2015-01-01

Background and objectives Data on mineral metabolism in pediatric renal transplant recipients largely arise from small single-center studies. In adult patients, abnormal mineral levels are related to a higher risk of graft failure. This study used data from the European Society for Paediatric Nephrology/European Renal Association–European Dialysis and Transplant Association Registry to study the prevalence and potential determinants of mineral abnormalities, as well as the predictive value of a disturbed mineral level on graft survival in a large cohort of European pediatric renal transplant recipients. Design, setting, participants, & measurements This study included 1237 children (0–17 years) from 10 European countries, who had serum calcium, phosphorus, and parathyroid hormone measurements from 2000 onward. Abnormalities of mineral metabolism were defined according to European guidelines on prevention and treatment of renal osteodystrophy in children on chronic renal failure. Results Abnormal serum phosphorus levels were observed in 25% (14% hypophosphatemia and 11% hyperphosphatemia), altered serum calcium in 30% (19% hypocalcemia, 11% hypercalcemia), and hyperparathyroidism in 41% of the patients. A longer time since transplantation was associated with a lower risk of having mineral levels above target range. Serum phosphorus levels were inversely associated with eGFR, and levels above the recommended targets were associated with a higher risk of graft failure independently of eGFR. Conclusions Abnormalities in mineral metabolism are common after pediatric renal transplantation in Europe and are associated with graft dysfunction. PMID:25710805

Controversy in the classroom: How eighth-grade and undergraduate students reason about tradeoffs of genetically modified food

NASA Astrophysics Data System (ADS)

Seethaler, Sherry Lynn

Current issues in science provide a rich context for learning because they can involve complex tradeoffs that cut across traditional disciplinary boundaries. Despite this potential benefit, and the need for citizens to make decisions about such issues, science controversy remains rare in the classroom. Consequently, there is much unknown about how students make sense of complex, multidisciplinary science. This research examined eighth-grade (n = 190) and undergraduate (n = 9) students' reasoning about tradeoffs in the genetically modified food controversy (main study). To extend the findings from the main study, undergraduate students' reasoning was followed as they learned about ten additional science controversies (extension). The studies took place in the context of curricula designed on the basis of the Scaffolded Knowledge Integration Framework, which posits a set of design principles that help students form a rich, integrated network of ideas about a topic. Two new methodologies were developed for this work. The Embedded Perspective of Science Controversy was used to study students' integration of content in their written arguments (main study) and oral and written questions (extension). The Perspective views science controversy as a set of nested levels, where tradeoffs are one of the levels, but connecting to other levels (underlying scientific details, bigger picture context, etc.) is important for the weighing of tradeoffs. A scheme based on Toulmin's (1958) work on argumentation provided a way of comparing the structure of students' arguments. As indicated by pre and post test scores, the curriculum helped both eighth-grade students (t = 11.7, p < 0.0001) and undergraduates (t = 13.9, p < 0.0001) learn about genetically modified food. In their final papers, both eighth-grade and undergraduate students presented evidence for and against their positions, in contrast with prior literature showing individuals have difficulty coming up with evidence against

[Ethical aspects of human embryonic stem cell use and commercial umbilical cord blood stem cell banking. Ethical reflections on the occasion of the regulation of the European Council and Parliament on advanced therapy medicinal products].

PubMed

Virt, G

2010-01-01

The regulation of the European Council and Parliament on advanced therapy medicinal products also includes therapies with human embryonic stem cells. The use of these stem cells is controversially and heavily discussed. Contrary to the use of adult stem cells, medical and ethical problems concerning the use of human embryonic stem cells persists, because this use is based on the destruction of human life at the very beginning. The regulation foresees, therefore, subsidiarity within the European Member States. Although there are no ethical problems in principle with the use of stem cells from the umbilical cord blood, there are social ethical doubts with the banking of these stem cells for autologous use without any currently foreseeable medical advantage by commercial blood banks. Also in this case subsidiarity is valid.

ACC/AHA guidelines superior to ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans: the Copenhagen General Population Study.

PubMed

Mortensen, Martin Bødtker; Nordestgaard, Børge G; Afzal, Shoaib; Falk, Erling

2017-02-21

We compared the 2013 American College of Cardiology/American Heart Association (ACC/AHA) and the 2016 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on prevention of atherosclerotic cardiovascular disease (ASCVD) using different risk prediction models [US Pooled Cohort Equations (US-PCE for any ASCVD) and European Systematic COronary Risk Evaluation system (European-SCORE for fatal ASCVD)] and different statin eligibility criteria. We examined 44 889 individuals aged 40-75 recruited in 2003-09 in the Copenhagen General Population Study, all free of ASCVD, diabetes, and statin use at baseline. We detected 2217 any ASCVD events and 199 fatal ASCVD events through 2014. The predicted-to-observed event ratio was 1.2 using US-PCE for any ASCVD and 5.0 using European-SCORE for fatal ASCVD. The US-PCE, but not the European-SCORE, was well-calibrated around decision thresholds for statin therapy. For a Class I recommendation, 42% of individuals qualified for statins using the ACC/AHA guidelines vs. 6% with the ESC/EAS guidelines. Using ACC/AHA- vs. ESC/EAS-defined statin eligibility led to a substantial gain in sensitivity (+62% for any ASCVD and +76% for fatal ASCVD) with a smaller loss in specificity (-35% for any ASCVD and -36% for fatal ASCVD). Similar differences between the ACC/AHA and ESC/EAS guidelines were found for men and women separately, and for Class IIa recommendations. The sensitivity and specificity of a US-PCE risk of 5% were similar to those of a European-SCORE risk of 1.4%, whereas a US-PCE risk of 7.5% was similar to a European-SCORE risk of 2.4%. The ACC/AHA guidelines were superior to the ESC/EAS guidelines for primary prevention of ASCVD, that is, for accurately assigning statin therapy to those who would benefit. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Cardiology

Occupational sensitization to epoxy resins in Northeastern Italy (1996-2010).

PubMed

Prodi, Andrea; Rui, Francesca; Fortina, Anna Belloni; Corradin, Maria Teresa; Filon, Francesca Larese

2015-01-01

One of the main health concerns of epoxy resins is their role as skin sensitizer. This sensitization is not uncommon, because the prevalence ranges around 1-12% of the general population. Perform a cross sectional study in a patch test population from Northeastern Italy to investigate the prevalence of epoxy resins sensitization among patients with suspected contact dermatitis. Subsequently, relate findings to patients' occupation and evaluate time trend of prevalence. The final study database included 19 088 consecutive patients, tested from 1996 to 2010 in Northeastern Italy. The overall prevalence of epoxy resins sensitization was 0·89%. Dermatitis most frequently involved hands (40·25%). In both sexes, we find a significant correlation in mechanics, woodworkers, and chemical industry workers; and in males only, among farmers and fishers, construction workers, and unemployed. We found significant increase of sensitization in construction workers in the analyzed period. The overall prevalence of sensitization to epoxy resins in Northeastern Italy is in line with other European countries, but we found an increased risk of sensitization in some professions and an increasing trend of prevalence in construction workers. Better preventive actions are strongly advised in higher risk professions, with particular attentions towards building sector.

World's fastest and most sensitive astronomical camera

NASA Astrophysics Data System (ADS)

2009-06-01

corrections to be done at an even higher rate, more than one thousand times a second, and this is where OCam is essential. "The quality of the adaptive optics correction strongly depends on the speed of the camera and on its sensitivity," says Philippe Feautrier from the LAOG, France, who coordinated the whole project. "But these are a priori contradictory requirements, as in general the faster a camera is, the less sensitive it is." This is why cameras normally used for very high frame-rate movies require extremely powerful illumination, which is of course not an option for astronomical cameras. OCam and its CCD220 detector, developed by the British manufacturer e2v technologies, solve this dilemma, by being not only the fastest available, but also very sensitive, making a significant jump in performance for such cameras. Because of imperfect operation of any physical electronic devices, a CCD camera suffers from so-called readout noise. OCam has a readout noise ten times smaller than the detectors currently used on the VLT, making it much more sensitive and able to take pictures of the faintest of sources. "Thanks to this technology, all the new generation instruments of ESO's Very Large Telescope will be able to produce the best possible images, with an unequalled sharpness," declares Jean-Luc Gach, from the Laboratoire d'Astrophysique de Marseille, France, who led the team that built the camera. "Plans are now underway to develop the adaptive optics detectors required for ESO's planned 42-metre European Extremely Large Telescope, together with our research partners and the industry," says Hubin. Using sensitive detectors developed in the UK, with a control system developed in France, with German and Spanish participation, OCam is truly an outcome of a European collaboration that will be widely used and commercially produced. More information The three French laboratories involved are the Laboratoire d'Astrophysique de Marseille (LAM/INSU/CNRS, Université de Provence

Sugars and Health Controversies: What Does the Science Say?123

PubMed Central

Rippe, James M; Angelopoulos, Theodore J

2015-01-01

The consumption of sugar and its relation to various potential adverse health consequences are the subjects of considerable debate and controversy. This supplement to Advances in Nutrition provides an expanded summary of a symposium held on 26 April 2014 entitled “Sugars and Health Controversies: What Does the Science Say?” as part of the ASN Scientific Sessions and Annual Meeting at Experimental Biology 2014. The articles in the supplement discuss results of current systematic reviews and meta-analyses as well as randomized controlled trials and draw implications for public policy considerations. In addition, future research gaps are identified. Current research trials conducted with commonly consumed sugars [e.g., sucrose and high-fructose corn syrup (HFCS)] do not support a unique relation to obesity, metabolic syndrome, diabetes, risk factors for heart disease, or nonalcoholic fatty liver disease. Neurologic differences in response to studies that used pure fructose compared with pure glucose have not been confirmed using typical sugars that are consumed (i.e., sucrose and HFCS), which contain ∼50% glucose and fructose. We conclude that added sugars consumed in the normal forms in which humans consume them, at amounts typical of the human diet and for the time period studied in randomized controlled trials, do not result in adverse health consequences. Although more research trials are needed in many areas of sugar consumption and health, there is little scientific justification for recommending restricting sugar consumption below the reasonable upper limit recommended by the Dietary Guidelines for Americans, 2010 of no more than 25% of calories.

European space programme

NASA Astrophysics Data System (ADS)

Luton, J.-M.

1992-02-01

Successful European Space Agency (ESA) programs include the Ariane launcher development, the Meteosat meteorological satellites and the Intelsat 6, ECS (European Communications Satellite) series of communications satellites. The ESA's policy of placing contracts with industrial companies in its 13 member countries has contributed to the strategic development of European high technology in the world market. The ESA's long-term programs, in addition to the Ariane launcher and Columbus/Hermes space-station/spaceplane programs, include participation in the International Space Station program, the Data Relay Satellite system and a variety of space applications programs. Two high-performance satellites to be placed in polar orbits will contribute to European environmental and climate variation studies and, together with the Polar Platform sector of the Columbus program, will drive the establishment and development of new institutions, industrial structures and infrastructure.

Effects of Synchronicity and Belongingness on Face-to-Face and Computer-Mediated Constructive Controversy

ERIC Educational Resources Information Center

Saltarelli, Andy J.; Roseth, Cary J.

2014-01-01

Adapting face-to-face (FTF) pedagogies to online settings raises boundary questions about the contextual conditions in which the same instructional method stimulates different outcomes. We address this issue by examining FTF and computer-mediated communication (CMC) versions of constructive controversy, a cooperative learning procedure involving…

Critical features of acute stress-induced cross-sensitization identified through the hypothalamic-pituitary-adrenal axis output.

PubMed

Belda, Xavier; Nadal, Roser; Armario, Antonio

2016-08-11

Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. One biological system particularly prone to sensitization is the hypothalamic-pituitary-adrenal (HPA) axis, the prototypic stress system. It is well established that under certain conditions, prior exposure of animals to acute and chronic (triggering) stressors enhances HPA responses to novel (heterotypic) stressors on subsequent days (e.g. raised plasma ACTH and corticosterone levels). However, such changes remain somewhat controversial and thus, the present study aimed to identify the critical characteristics of the triggering and challenging stressors that affect acute stress-induced HPA cross-sensitization in adult rats. We found that HPA cross-sensitization is markedly influenced by the intensity of the triggering stressor, whereas the length of exposure mainly affects its persistence. Importantly, HPA sensitization is more evident with mild than strong challenging stressors, and it may remain unnoticed if exposure to the challenging stressor is prolonged beyond 15 min. We speculate that heterotypic HPA sensitization might have developed to optimize biologically adaptive responses to further brief stressors.

Critical features of acute stress-induced cross-sensitization identified through the hypothalamic-pituitary-adrenal axis output

PubMed Central

Belda, Xavier; Nadal, Roser; Armario, Antonio

2016-01-01

Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. One biological system particularly prone to sensitization is the hypothalamic-pituitary-adrenal (HPA) axis, the prototypic stress system. It is well established that under certain conditions, prior exposure of animals to acute and chronic (triggering) stressors enhances HPA responses to novel (heterotypic) stressors on subsequent days (e.g. raised plasma ACTH and corticosterone levels). However, such changes remain somewhat controversial and thus, the present study aimed to identify the critical characteristics of the triggering and challenging stressors that affect acute stress-induced HPA cross-sensitization in adult rats. We found that HPA cross-sensitization is markedly influenced by the intensity of the triggering stressor, whereas the length of exposure mainly affects its persistence. Importantly, HPA sensitization is more evident with mild than strong challenging stressors, and it may remain unnoticed if exposure to the challenging stressor is prolonged beyond 15 min. We speculate that heterotypic HPA sensitization might have developed to optimize biologically adaptive responses to further brief stressors. PMID:27511270

Patently controversial: markets, morals, and the President's proposal for embryonic stem cell research.

PubMed

Fins, Joseph J; Schachter, Madeleine

2002-09-01

This essay considers the implications of President George W. Bush's proposal for human embryonic stem cell research. Through the perspective of patent law, privacy, and informed consent, we elucidate the ongoing controversy about the moral standing of human embryonic stem cells and their derivatives and consider how the inconsistencies in the president's proposal will affect clinical practice and research.

Eurasiaplex: a forensic SNP assay for differentiating European and South Asian ancestries.

PubMed

Phillips, C; Freire Aradas, A; Kriegel, A K; Fondevila, M; Bulbul, O; Santos, C; Serrulla Rech, F; Perez Carceles, M D; Carracedo, Á; Schneider, P M; Lareu, M V

2013-05-01

We have selected a set of single nucleotide polymorphisms (SNPs) with the specific aim of differentiating European and South Asian ancestries. The SNPs were combined into a 23-plex SNaPshot primer extension assay: Eurasiaplex, designed to complement an existing 34-plex forensic ancestry test with both marker sets occupying well-spaced genomic positions, enabling their combination as single profile submissions to the Bayesian Snipper forensic ancestry inference system. We analyzed the ability of Eurasiaplex plus 34plex SNPs to assign ancestry to a total 1648 profiles from 16 European, 7 Middle East, 13 Central-South Asian and 21 East Asian populations. Ancestry assignment likelihoods were estimated from Snipper using training sets of five-group data (three Eurasian groups, East Asian and African genotypes) and four-group data (Middle East genotypes removed). Five-group differentiations gave assignment success of 91% for NW European populations, 72% for Middle East populations and 39% for Central-South Asian populations, indicating Middle East individuals are not reliably differentiated from either Europeans or Central-South Asians. Four-group differentiations provided markedly improved assignment success rates of 97% for most continental Europeans tested (excluding Turkish and Adygei at the far eastern edge of Europe) and 95% for Central-South Asians, despite applying a probability threshold for the highest likelihood ratio above '100 times more likely'. As part of the assessment of the sensitivity of Eurasiaplex to analyze challenging forensic material we detail Eurasiaplex and 34-plex SNP typing to infer ancestry of a cranium recovered from the sea, achieving 82% SNP genotype completeness. Therefore, Eurasiaplex provides an informative and forensically robust approach to the differentiation of European and South Asian ancestries amongst Eurasian populations. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Advanced Concepts and Controversies in Emergency Department Pain Management.

PubMed

Motov, Sergey M; Nelson, Lewis S

2016-06-01

Pain is the most common complaint for which patients come to the emergency department (ED). Emergency physicians are responsible for pain relief in a timely, efficient, and safe manner in the ED. The improvement in our understanding of the neurobiology of pain has balanced the utilization of nonopioid and opioid analgesia, and simultaneously has led to more rational and safer opioid prescribing practices. This article reviews advances in pain management in the ED for patients with acute and chronic pain as well as describes several newer strategies and controversies. Copyright © 2016 Elsevier Inc. All rights reserved.

European monitoring for raptors and owls: state of the art and future needs.

PubMed

Kovács, András; Mammen, Ubbo C C; Wernham, Chris V

2008-09-01

Sixty-four percent of the 56 raptor and owl species that occur in Europe have an unfavorable conservation status. As well as requiring conservation measures in their own right, raptors and owls function as useful sentinels of wider environmental "health," because they are widespread top predators, relatively easy to monitor, and sensitive to environmental changes at a range of geographical scales. At a time of global acknowledgment of an increasing speed of biodiversity loss, and new, forward-looking and related European Union biodiversity policy, there is an urgent need to improve coordination at a pan-European scale of national initiatives that seek to monitor raptor populations. Here we describe current initiatives that make a contribution to this aim, particularly the current "MEROS" program, the results of a questionnaire survey on the current state of national raptor monitoring across 22 BirdLife Partners in Europe, the challenges faced by any enhanced pan-European monitoring scheme for raptors, and some suggested pathways for efficiently tapping expertise to contribute to such an initiative.

Assessing the public's views in research ethics controversies: deliberative democracy and bioethics as natural allies.

PubMed

Kim, Scott Y H; Wall, Ian F; Stanczyk, Aimee; De Vries, Raymond

2009-12-01

In a liberal democracy, policy decisions regarding ethical controversies, including those in research ethics, should incorporate the opinions of its citizens. Eliciting informed and well-considered ethical opinions can be challenging. The issues may not be widely familiar and they may involve complex scientific, legal, historical, and ethical dimensions. Traditional surveys risk eliciting superficial and uninformed opinions that may be of dubious quality for policy formation. We argue that the theory and practice of deliberative democracy (DD) is especially useful in overcoming such inadequacies. We explain DD theory and practice, discuss the rationale for using DD methods in research ethics, and illustrate in depth the use of a DD method for a longstanding research ethics controversy involving research based on surrogate consent. The potential pitfalls of DD and the means of minimizing them as well as future research directions are also discussed.

Scientific literacy for citizenship: Tools for dealing with the science dimension of controversial socioscientific issues

NASA Astrophysics Data System (ADS)

Kolst, Stein D.

2001-05-01

This article offers a general framework for examining the science dimension of controversial socioscientific issues. Eight specific content-transcending topics to be emphasized in science education are proposed. The topics are grouped under the headings science as a social process, limitations of science, values in science, and critical attitude. Each topic is explored, and it is argued that knowledge of the topics can serve as tools for students' examination of science-related claims in controversial socioscientific issues. The underlying perspective here is empowerment and the needs of students as lay people. The need of society as a whole for decisions to be made on a broad and firm basis is nevertheless also included. The main reason for suggesting the eight content-transcending topics is to provide focal points for the future development of teaching models aimed at science education for citizenship.

A New Impetus for European Youth. European Commission White Paper.

ERIC Educational Resources Information Center

Commission of the European Communities, Brussels (Belgium).

Despite their highly divergent situations, young people largely share the same values, ambitions, and difficulties. Despite the more complex social and economic context in which young Europeans are currently living, they are well equipped to adapt. National and European policymakers must facilitate this process of change by making young people…

Analysis of Internet information on the controversial X-Stop device.

PubMed

Anderson, Joshua T; Sullivan, T Barrett; Ahn, Uri M; Ahn, Nicholas U

2014-10-01

The Internet is frequently used by patients to aid in medical decision making. Multiple studies display the Internet's ineffectiveness in presenting high-quality information regarding surgical procedures and devices. With recent reports of unacceptably high complication rates and poor outcomes with the X-Stop device, it is important that online information is comprehensive and accurate. This study is the first to examine Internet information on the controversial X-Stop. To determine how accurately public information over the Internet portrays the existing primary literature on the X-Stop, how extensively the X-Stop is characterized online, and how patient decision making could foreseeably be affected. This cross-sectional study analyzed publicly available Internet information, including videos on the web site YouTube regarding the X-Stop device. No patients were involved in this study. No specific outcome measures were used. Search engines Google, Yahoo, and Bing were used to identify 105 web sites providing information on the X-Stop. Videos on the web site YouTube were included. Web sites were categorized based on the authorship. Each site was analyzed for the provision of appropriate patient inclusion and exclusion criteria, surgical and nonsurgical treatment alternatives, purported benefits, common complications, peer-reviewed literature citations, and descriptions/diagrams of the procedure. Data were evaluated for each authorship subgroup and the entire group of sites. Forty-three percent of sites were authored by a private medical group, 4% by an academic medical group, 16% by an insurance company, 9% by a biomedical industry, 10% by news sources, and 19% by other. Thirty-one percent of web sites and 11% of sites authored by private medical groups contained references to peer-reviewed literature. Fifty-six percent of web sites reported patient inclusion criteria, whereas 33% reported exclusion criteria. Benefits and complications were reported within 91% and

Educational Pluralism and Freedom of Religion: Recent Decisions of the European Court of Human Rights

ERIC Educational Resources Information Center

Relano, Eugenia

2010-01-01

This paper addresses the sensitive issue of the teaching of religions and beliefs in schools by analysing two recent decisions of the European Court of Human Rights. In these cases, the Court asserts that students should be exempted from compulsory courses on religion or from courses that are not conveyed in an objective, critical and pluralist…

Comment on ``Mesoplates: Resolving a Decades-Old Controversy''

NASA Astrophysics Data System (ADS)

Liu, Han-Shou; Kolenkiewicz, R.

2004-07-01

Plate tectonics is primarily a geokinematic theory. Additional new concepts or components are needed to provide insights and constrains for geodynamic modeling. Recently, in Eos (23 December 2003), Pilger has developed a new concept regarding the kinematics of the lithospheric plates and the underlying mesosphere. He proposed that three mesoplates under the lithosphere can provide a framework for resolving a decades-old controversy on hot spots and mantle plumes. Geodynamic modelers are forced to establish the existence of these three mesoplates. We have attempted to verify the mesoplate hypothesis using satellite gravity signals for remote sensing the stresses in the mesosphere. Our stress patterns of the mesosphere at 100 km depth as inferred from satellite gravity signals show that global stress concentrations are mainly restricted to the boundaries of the Hawaiian, Tristan, and Icelandic Mesoplate as defined by Pilger.

Consensus or controversy? The classification and treatment decision-making by 491 maxillofacial surgeons from around the world in three cases of a unilateral mandibular condyle fracture.

PubMed

Kommers, Sofie C; Boffano, Paolo; Forouzanfar, Tymour

2015-12-01

Many studies are available in the literature on both classification and treatment of unilateral mandibular condyle fractures. To date however, controversy regarding the best treatment for unilateral mandibular condyle fractures remains. In this study, an attempt was made to quantify the level of agreement between a sample of maxillofacial surgeons worldwide, on the classification and treatment decisions in three different unilateral mandibular condyle fracture cases. In total, 491 of 3044 participants responded. In all three mandibular condyle fracture cases, a fairly high level of disagreement was found. Only in the case of a subcondylar fracture, assuming dysocclusion was present, more than 81% of surgeons agreed that the best treatment would be open reduction and internal fixation. Based on the study results, there is considerable variation among surgeons worldwide with regard to treatment of unilateral mandibular condyle fracture. 3D imaging in higher fractures tends to lead to more invasive treatment decisions. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

The Pedagogy of Controversy in the Field of China Studies: Teaching the Cultural Revolution

ERIC Educational Resources Information Center

Carrico, Kevin

2014-01-01

How can we as educators address complex and controversial topics in the social sciences without encouraging simplistic responses and self-reproducing binary oppositions? Drawing upon an ethnographic analysis of a first-year writing seminar on the history of the Chinese Cultural Revolution, this article proposes novel approaches to overcome…

Science and Social Studies Teachers' Beliefs and Practices about Teaching Controversial Issues: Certain Comparisons

ERIC Educational Resources Information Center

Kus, Zafer

2015-01-01

The current study aims to investigate social studies and science teachers' attitudes and classroom practices associated with controversial issues. The study is a qualitative research based on data collected through interviews and observation. Social studies and Science teachers participated in the current study which was conducted in Kirsehir, a…

Adult Attachment States of Mind: Measurement Invariance across Ethnicity and Associations with Maternal Sensitivity

ERIC Educational Resources Information Center

Haltigan, John D.; Leerkes, Esther M.; Wong, Maria S.; Fortuna, Keren; Roisman, Glenn I.; Supple, Andrew J.; O'Brien, Marion; Calkins, Susan D.; Plamondon, André

2014-01-01

This study examined the developmental significance of mothers' adult attachment representations assessed prenatally with the Adult Attachment Interview in relation to observed maternal sensitivity at 6 months postpartum in an ethnically diverse sample (N = 131 African American; N = 128 European American). Multiple-group confirmatory factor…

Initiation of the Pyrenean plate boundary fault and its effect on the near- and far-field deformation of the European plate

NASA Astrophysics Data System (ADS)

Dielforder, Armin; Frasca, Gianluca; Ford, Mary

2017-04-01

The European plate was affected by contractional deformation events in Late Cretaceous time. This is recorded by inception of thrusting and foreland basin subsidence in the Pyrenean realm, and inversion of Mesozoic rift systems in the interior of the European plate. It is widely accepted that the plate-wide deformation resulted from the onset of NE-directed convergence of Africa-Iberia relative to Europe, and a strong mechanical coupling of the plates, which allowed the transfer of stresses far into Europe. Geological data from both the Pyrenean orogen and the interior of the European plate indicate, however, that these conditions persisted only for 15-20 Myr and that Europe experienced a plate-wide stress relaxation during Paleocene time. Although a slow down in plate convergence between Africa and Europe and North Atlantic continental rifting were proposed as potential causes for the stress relaxation, the subject has remained controversial. In particular, none of the mechanisms seem to be suitable to explain the required changes in the mechanical coupling of Iberian and European plates and the associated stress transfer. Here we propose a new model for the Upper Cretaceous to Paleocene tectonic evolution of the European plate, which takes the temporal evolution of the Pyrenean plate boundary fault into account. Based on plate reconstructions, geological field-data, and restored cross-sections we argue that the plate boundary fault initiated during the Upper Cretaceous within the exhumed mantle domain situated between the rifted margins of the Iberian and European plates. At the transition from the Late Cretaceous to Paleocene, the mantle domain was closed and the rifted margins collided. This evolution was associated with a substantial change in the fault rheology leading to an overall decrease in the plate coupling force. During Paleocene time, the plate coupling force was efficiently balanced by the gravitational push of the European plate, leading to a near

Bureaucratic Constructions of Sexual Diversity: "Sensitive", "Controversial" and Silencing

ERIC Educational Resources Information Center

Ullman, Jacqueline; Ferfolja, Tania

2015-01-01

National research illustrates the high degree of discrimination that prevails against lesbian, gay, bisexual, transgender and queer (LGBTQ) students resulting in diminished educational outcomes, both academic and social. This phenomenon is influenced by the prevalence of whole-school silences around LGBTQ topics in many Australian schools. This…

European Science Notes Information Bulletin Reports on Current European/ Middle Eastern Science

DTIC Science & Technology

1991-03-01

energies and furniture-rotating machinery, and marine. A list of the power density which can be precisely controlled . In European research centers in...43 ESNIB 91-02 By controlling the growth of layers of Si and Si/Ge be the domain of the II-V semiconductors, ar- niwbeing alloys, many research ...Office of Naval Research European Office 91-02 AD-A233 618 ESN INFORMATION BULLETIN European Science Notes Information Bulletin Reports on Current

Integration through Europeanization: Ukraine’s Policy Towards the European Union

DTIC Science & Technology

2012-06-08

who have applied to the European Union and have been accepted in principle are: Iceland, Macedonia, Montenegro , Serbia and Turkey. See, European......the one hand, and the Contracting Parties: Albania, Bosnia and Herzegovina, Croatia, former Yugoslav Republic of Macedonia, Moldova, Montenegro

Students' Socio-Scientific Reasoning on Controversies from the Viewpoint of Education for Sustainable Development

ERIC Educational Resources Information Center

Simonneaux, Laurence; Simonneaux, Jean

2009-01-01

In this article, we study third-year university students' reasoning about three controversial socio-scientific issues from the viewpoint of education for sustainable development: local issues (the reintroduction of bears in the Pyrenees in France, wolves in the Mercantour) and a global one (global warming). We used the theoretical frameworks of…

Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials.

PubMed

Sakaguchi, Hitoshi; Ryan, Cindy; Ovigne, Jean-Marc; Schroeder, Klaus R; Ashikaga, Takao

2010-09-01

Regulatory policies in Europe prohibited the testing of cosmetic ingredients in animals for a number of toxicological endpoints. Currently no validated non-animal test methods exist for skin sensitization. Evaluation of changes in cell surface marker expression in dendritic cell (DC)-surrogate cell lines represents one non-animal approach. The human Cell Line Activation Test (h-CLAT) examines the level of CD86 and CD54 expression on the surface of THP-1 cells, a human monocytic leukemia cell line, following 24h of chemical exposure. To examine protocol transferability, between-lab reproducibility, and predictive capacity, the h-CLAT has been evaluated by five independent laboratories in several ring trials (RTs) coordinated by the European Cosmetics Association (COLIPA). The results of the first and second RTs demonstrated that the protocol was transferable and basically had good between-lab reproducibility and predictivity, but there were some false negative data. To improve performance, protocol and prediction model were modified. Using the modified prediction model in the first and second RT, accuracy was improved. However, about 15% of the outcomes were not correctly identified, which exposes some of the limitations of the assay. For the chemicals evaluated, the limitation may due to chemical being a weak allergen or having low solubility (ex. alpha-hexylcinnamaldehyde). The third RT evaluated the modified prediction model and satisfactory results were obtained. From the RT data, the feasibility of utilizing cell lines as surrogate DC in development of in vitro skin sensitization methods shows promise. The data also support initiating formal pre-validation of the h-CLAT in order to fully understand the capabilities and limitations of the assay. Copyright 2010 Elsevier Ltd. All rights reserved.

Cat and dog sensitization in pet shop workers.

PubMed

Yilmaz, I; Oner Erkekol, F; Secil, D; Misirligil, Z; Mungan, D

2013-12-01

Sensitivity and symptoms related to animal proteins have been investigated in various occupational groups. However, data from pet shops are limited. To investigate rates of sensitivity to cats and dogs among pet shop workers, to assess the relationship between sensitivity, allergen levels and symptoms and to investigate whether passive transport from pet shops to homes is possible. Pet shop workers underwent interviews with a questionnaire adapted from the European Community Respiratory Health Survey. Dust samples for allergen detection were collected from pet shops using a vacuum cleaner. Skin tests were performed with common allergens. Dust samples were also obtained from the houses of 7 workers and 12 control subjects. Fifty-one workers from 20 pet shops were included in the study. Thirteen (25%) workers reported work-related symptoms. Four workers had sensitivity to animal allergens. The mean cat/dog allergen levels from pet shops were 15.7 and 3.2 µg/g, respectively. There was no significant relationship between cat/dog allergen levels and work-related symptoms and sensitivity to pets. None of the dust samples collected from the homes of pet shop workers contained cat allergens. Dog allergen was detected in only one house (0.58 µg/g). Neither cat nor dog allergens were found in the homes of the 12 control subjects. Although a quarter of pet shop workers reported work-related symptoms, sensitivity to cat and dog was low. These findings suggest that work-related symptoms may be due to other factors than cat and dog sensitivity.

Balance between climate change mitigation benefits and land use impacts of bioenergy: conservation implications for European birds.

PubMed

Meller, Laura; Thuiller, Wilfried; Pironon, Samuel; Barbet-Massin, Morgane; Hof, Andries; Cabeza, Mar

2015-07-01

Both climate change and habitat modification exert serious pressure on biodiversity. Although climate change mitigation has been identified as an important strategy for biodiversity conservation, bioenergy remains a controversial mitigation action due to its potential negative ecological and socio-economic impacts which arise through habitat modification by land-use change. While the debate continues, the separate or simultaneous impacts of both climate change and bioenergy on biodiversity have not yet been compared. We assess projected range shifts of 156 European bird species by 2050 under two alternative climate change trajectories: a baseline scenario, where the global mean temperature increases by 4°C by the end of the century, and a 2 degrees scenario, where global concerted effort limits the temperature increase to below 2°C. For the latter scenario, we also quantify the pressure exerted by increased cultivation of energy biomass as modelled by IMAGE2.4, an integrated land-use model. The global bioenergy use in this scenario is in the lower end of the range of previously estimated sustainable potential. Under the assumptions of these scenarios, we find that the magnitude of range shifts due to climate change is far greater than the impact of land conversion to woody bioenergy plantations within the European Union, and that mitigation of climate change reduces the exposure experienced by species. However, we identified potential for local conservation conflict between priority areas for conservation and bioenergy production. These conflicts must be addressed by strict bioenergy sustainability criteria that acknowledge biodiversity conservation needs beyond existing protected areas and apply also to biomass imported from outside the European Union.

Balance between climate change mitigation benefits and land use impacts of bioenergy: conservation implications for European birds

PubMed Central

Meller, Laura; Thuiller, Wilfried; Pironon, Samuel; Barbet-Massin, Morgane; Hof, Andries; Cabeza, Mar

2015-01-01

Both climate change and habitat modification exert serious pressure on biodiversity. Although climate change mitigation has been identified as an important strategy for biodiversity conservation, bioenergy remains a controversial mitigation action due to its potential negative ecological and socio-economic impacts which arise through habitat modification by land-use change. While the debate continues, the separate or simultaneous impacts of both climate change and bioenergy on biodiversity have not yet been compared. We assess projected range shifts of 156 European bird species by 2050 under two alternative climate change trajectories: a baseline scenario, where the global mean temperature increases by 4°C by the end of the century, and a 2 degrees scenario, where global concerted effort limits the temperature increase to below 2°C. For the latter scenario, we also quantify the pressure exerted by increased cultivation of energy biomass as modelled by IMAGE2.4, an integrated land-use model. The global bioenergy use in this scenario is in the lower end of the range of previously estimated sustainable potential. Under the assumptions of these scenarios, we find that the magnitude of range shifts due to climate change is far greater than the impact of land conversion to woody bioenergy plantations within the European Union, and that mitigation of climate change reduces the exposure experienced by species. However, we identified potential for local conservation conflict between priority areas for conservation and bioenergy production. These conflicts must be addressed by strict bioenergy sustainability criteria that acknowledge biodiversity conservation needs beyond existing protected areas and apply also to biomass imported from outside the European Union. PMID:26681982

News coverage of controversial emerging technologies. Evidence for the issue attention cycle in print and online media.

PubMed

Anderson, Ashley A; Brossard, Dominique; Scheufele, Dietram A

2012-01-01

This study analyzes the issue attention cycle for print and online media coverage of a scientific publication examining the deaths of Chinese factory workers due to lung damage from chronic exposure to nanoparticles. The results of the nanoparticle study, published in 2009, embody news values that would make the study a prime candidate for press coverage, namely, novelty, negativity, controversy, and potential widespread impact. Nevertheless, mentions of the event in traditional English-language print media were nearly nonexistent. Online media, on the other hand, gave the story greater coverage. This case study exemplifies why online media may not be bound to the same issue attention cycle that print media are for controversial scientific events.

Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis.

PubMed

Gao, Huanqing; Geng, Tingting; Huang, Tao; Zhao, Qinghua

2017-07-03

Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular disease, type 2 diabetes and several types of cancers. However, the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial. This meta-analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aimed to evaluate whether fish oil supplementation could improve insulin sensitivity. We searched the Cochrane Library, PubMed, Embase database for the relevant studies update to Dec 2016. Two researchers screened the literature independently by the selection and exclusion criteria. Studies were pooled using random effect models to estimate a pooled SMD and corresponding 95% CI. This meta-analysis was performed by Stata 13.1 software. A total of 17 studies with 672 participants were included in this meta-analysis study after screening from 498 published articles found after the initial search. In a pooled analysis, fish oil supplementation had no effects on insulin sensitivity compared with the placebo (SMD 0.17, 95%CI -0.15 to 0.48, p = 0.292). In subgroup analysis, fish oil supplementation could benefit insulin sensitivity among people who were experiencing at least one symptom of metabolic disorders (SMD 0.53, 95% CI 0.17 to 0.88, p < 0.001). Similarly, there were no significant differences between subgroups of methods of insulin sensitivity, doses of omega-3 polyunsaturated fatty acids (n-3 PUFA) of fish oil supplementation or duration of the intervention. The sensitivity analysis indicated that the results were robust. Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders.