The Arkansas Nightmare.

ERIC Educational Resources Information Center

Schoppmeyer, Martin W., Sr.; Noggle, F. Kellar; Portman, Gerald L.; Schoppmeyer, Martin W., Jr.

This paper examines recent efforts in Arkansas to nullify property taxes. It describes how anti-tax citizens, whose push for a constitutional amendment in 1998 was thwarted by the state supreme court, have vowed to collect enough signatures to place the amendment on the 2000 ballot. The proposed amendment will abolish ad valorem taxes upon real…

26 CFR 1.164-3 - Definitions and special rules.

Code of Federal Regulations, 2011 CFR

2011-04-01

... sold, and the term “medical supplies” includes drugs, medicines, and medical devices. (4) Except in the... qualify as ad valorem. For example, a motor vehicle tax based on weight, model year, and horsepower, or..., clothing, medical supplies, and motor vehicles, or any of them, shall not be taken into account in...

40 CFR 35.929-2 - General requirements for all user charge systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of the user charges or ad valorem taxes which are attributable to waste water treatment services. (g... than every 2 years the waste water contribution of users and user classes, the total costs of operation... subscribers receiving waste treatment services from the grantee shall adopt user charge systems in accordance...

40 CFR 35.929-2 - General requirements for all user charge systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of the user charges or ad valorem taxes which are attributable to waste water treatment services. (g... than every 2 years the waste water contribution of users and user classes, the total costs of operation... subscribers receiving waste treatment services from the grantee shall adopt user charge systems in accordance...

30 CFR 206.257 - Valuation standards for ad valorem leases.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., were not part of the total consideration paid for the purchase of coal production. (c)(1) The value of... with the lessee for sales, purchases, or other dispositions of like-quality coal produced in the area... following factors shall be considered: Price, time of execution, duration, market or markets served, terms...

30 CFR 210.203 - How do I submit sales contracts?

Code of Federal Regulations, 2010 CFR

2010-07-01

... royalty terms. (b) When to submit. (1) For coal and metal production, you must submit the required... MANAGEMENT FORMS AND REPORTS Production and Royalty Reports-Solid Minerals § 210.203 How do I submit sales..., and phosphate production, and production from any other lease with ad valorem royalty terms, you must...

30 CFR 206.264 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false In-situ and surface gasification and... THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Coal § 206.264 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in-situ or...

30 CFR 1206.463 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false In-situ and surface gasification and..., DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Indian Coal § 1206.463 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in...

30 CFR 1206.463 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false In-situ and surface gasification and..., DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Indian Coal § 1206.463 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in...

30 CFR 1206.264 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false In-situ and surface gasification and..., DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.264 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in...

30 CFR 206.463 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false In-situ and surface gasification and... THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Coal § 206.463 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in-situ or...

30 CFR 1206.264 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false In-situ and surface gasification and..., DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.264 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in...

30 CFR 1206.463 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false In-situ and surface gasification and..., DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Indian Coal § 1206.463 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in...

30 CFR 1206.264 - In-situ and surface gasification and liquefaction operations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false In-situ and surface gasification and..., DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE PRODUCT VALUATION Federal Coal § 1206.264 In-situ and surface gasification and liquefaction operations. If an ad valorem Federal coal lease is developed by in...

40 CFR 35.929-1 - Approval of the user charge system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the grantee's costs of waste water treatment services; (B) The grantee's budgeting and accounting... operation and maintenance; (C) The ad valorem tax system collected tax funds for the costs of waste water..., which required the subscriber to pay its share of the cost of waste water treatment services. (4) A user...

40 CFR 35.929-1 - Approval of the user charge system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the grantee's costs of waste water treatment services; (B) The grantee's budgeting and accounting... operation and maintenance; (C) The ad valorem tax system collected tax funds for the costs of waste water..., which required the subscriber to pay its share of the cost of waste water treatment services. (4) A user...

40 CFR 35.929-1 - Approval of the user charge system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the grantee's costs of waste water treatment services; (B) The grantee's budgeting and accounting... operation and maintenance; (C) The ad valorem tax system collected tax funds for the costs of waste water..., which required the subscriber to pay its share of the cost of waste water treatment services. (4) A user...

40 CFR 35.929-1 - Approval of the user charge system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the grantee's costs of waste water treatment services; (B) The grantee's budgeting and accounting... operation and maintenance; (C) The ad valorem tax system collected tax funds for the costs of waste water..., which required the subscriber to pay its share of the cost of waste water treatment services. (4) A user...

40 CFR 35.929-1 - Approval of the user charge system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the grantee's costs of waste water treatment services; (B) The grantee's budgeting and accounting... operation and maintenance; (C) The ad valorem tax system collected tax funds for the costs of waste water..., which required the subscriber to pay its share of the cost of waste water treatment services. (4) A user...

19 CFR 191.26 - Recordkeeping for manufacturing drawback.

Code of Federal Regulations, 2014 CFR

2014-04-01

... analysis in the entry papers to be 91.7% pure titanium dioxide is imported and dutiable at a 5% ad valorem.... The total duty paid is $600. Titanium in the synthetic rutile is designated as the basis for a drawback claim under 19 U.S.C. 1313(b). The amount of titanium dioxide in the synthetic rutile is...

Incidence of Russian log export tax: A vertical log-lumber model

Treesearch

Ying Lin; Daowei Zhang

2017-01-01

In 2007, Russia imposed an ad valorem tax on its log exports that lasted until 2012. In this paper, weuse a Muth-type equilibrium displacement model to investigate the market and welfare impacts of this tax, utilizing a vertical linkage between log and lumber markets and considering factor substitution. Our theoretical analysis indicates...

The Changing Role of the School Attorney: Protecting and Exploiting Sources of Revenue for Schools.

ERIC Educational Resources Information Center

Simiele, Thomas C.

This paper describes ways in which the public school district can cut costs, similar to those utilized by the private sector in a shrinking economy. One strategy is to generate new revenue and protect old revenue from erosion through "ad valorem" taxation of real property. Between appraisal years, schools districts can actively seek out…

19 CFR 10.13 - Statutory provision: Subheading 9802.00.80, Harmonized Tariff Schedule of the United States (19 U...

Code of Federal Regulations, 2011 CFR

2011-04-01

... the exemption bears to the full value of the assembled article. Example 1. A transistor radio is assembled abroad from foreign-made components and American-made transistors. Upon importation, the transistor radio is subject to the ad valorem rate of duty applicable to transistor radios upon the value of...

19 CFR 10.13 - Statutory provision: Subheading 9802.00.80, Harmonized Tariff Schedule of the United States (19 U...

Code of Federal Regulations, 2012 CFR

2012-04-01

... the exemption bears to the full value of the assembled article. Example 1. A transistor radio is assembled abroad from foreign-made components and American-made transistors. Upon importation, the transistor radio is subject to the ad valorem rate of duty applicable to transistor radios upon the value of...

19 CFR 10.13 - Statutory provision: Subheading 9802.00.80, Harmonized Tariff Schedule of the United States (19 U...

Code of Federal Regulations, 2014 CFR

2014-04-01

... the exemption bears to the full value of the assembled article. Example 1. A transistor radio is assembled abroad from foreign-made components and American-made transistors. Upon importation, the transistor radio is subject to the ad valorem rate of duty applicable to transistor radios upon the value of...

19 CFR 10.13 - Statutory provision: Subheading 9802.00.80, Harmonized Tariff Schedule of the United States (19 U...

Code of Federal Regulations, 2013 CFR

2013-04-01

... the exemption bears to the full value of the assembled article. Example 1. A transistor radio is assembled abroad from foreign-made components and American-made transistors. Upon importation, the transistor radio is subject to the ad valorem rate of duty applicable to transistor radios upon the value of...

19 CFR 10.13 - Statutory provision: Subheading 9802.00.80, Harmonized Tariff Schedule of the United States (19 U...

Code of Federal Regulations, 2010 CFR

2010-04-01

... the exemption bears to the full value of the assembled article. Example 1. A transistor radio is assembled abroad from foreign-made components and American-made transistors. Upon importation, the transistor radio is subject to the ad valorem rate of duty applicable to transistor radios upon the value of...

19 CFR 351.525 - Calculation of ad valorem subsidy rate and attribution of subsidy to a product.

Code of Federal Regulations, 2010 CFR

2010-04-01

... by dividing the amount of the benefit allocated to the period of investigation or review by the sales... under paragraph (b) of this section. Normally, the Secretary will determine the sales value of a product... product. (i) In general. If a subsidy is tied to the production or sale of a particular product, the...

78 FR 67112 - Fresh Garlic From the People's Republic of China: Preliminary Results of New Shipper Review of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... is above de minimis, we will calculate importer-specific ad valorem duty assessment rate based on the...- average dumping margin is zero or de minimis, or an importer-specific assessment rate is zero or de... final results of this review (except, if the rate is zero or de minimis, then zero cash deposit will be...

Tax, price and cigarette brand preferences: a longitudinal study of adult smokers from the ITC Mexico Survey.

PubMed

Sáenz de Miera Juárez, Belén; Thrasher, James F; Reynales Shigematsu, Luz Myriam; Hernández Ávila, Mauricio; Chaloupka, Frank J

2014-03-01

Recent tax increases in Mexico differed in structure and provided an opportunity to better understand tobacco industry pricing strategies, as well as smokers' responses to any resulting price changes. To assess if taxes were passed onto consumers of different cigarette brands, the extent of brand switching and predictors of preference for cheaper national brands. Using data from three waves of the Mexican administration of the International Tobacco Control Survey, we analysed self-reported brand and price paid at last cigarette purchase. Generalised estimating equations were used to determine predictors of price and preference for national brands. The average price of premium/international brands increased each year from 2008 to 2011; however, the price for discount/national brands increased only from 2010 to 2011. The percentage of smokers who smoked national brands remained stable between 2008 and 2010 but dropped in 2011. Factors related to smoking national brands as opposed to international brands included being male and having relatively older age, lower education, lower income and higher consumption. Tobacco industry pricing strategies in the wake of ad valorem taxes implemented in Mexico prior to 2011 had the impact of segmenting the market into discount national brands and premium international brands. The specific tax increase implemented in 2011 reduced the price gap between these two segments by raising the price of the national brands relative to the international brands. Evidence for trading up was found after the 2011 tax increase. These results provide further evidence for the relevance of tax policy as a tobacco control strategy; in particular, they illustrate the importance of how specific rather than ad valorem taxes can reduce the potential for downward brand switching in the face of decreasing cigarette affordability.

Tax, price, and cigarette brand preferences: A longitudinal study of adult smokers from the ITC Mexico Survey

PubMed Central

Sáenz de Miera Juárez, Belén; Thrasher, James F; Reynales Shigematsu, Luz Myriam; Hernández Ávila, Mauricio; Chaloupka, Frank J

2014-01-01

Background Recent tax increases in Mexico differed in structure and provide an opportunity to better understand tobacco industry pricing strategies, as well as smokers’ responses to any resulting price changes. Objectives To assess if taxes were passed onto consumers of different cigarette brands, the extent of brand switching, and predictors of preference for cheaper national brands. Methods Using data from three waves of the Mexican administration of the ITC Survey, we analyzed self-reported brand and price paid at last cigarette purchase. Generalized estimating equations were used to determine predictors of price and preference for national brands. Results The average price of premium/international brands increased each year from 2008–2011; however, the price for discount/national brands increased only from 2010 to 2011. The percentage of smokers who smoked national brands remained stable between 2008 and 2010 but dropped in 2011. Factors related to smoking national as opposed to international brands included being male and having relatively older age, lower education, lower income, and higher consumption. Conclusions Tobacco industry pricing strategies in the wake of ad valorem taxes implemented in Mexico prior to 2011 had the impact of segmenting the market into discount national brands and premium international brands. The specific tax increase implemented in 2011 reduced the price gap between these two segments, by raising the price of the national brands relative to the international brands. Evidence for trading up was found after the 2011 tax increase. These results provide further evidence for the relevance of tax policy as a tobacco control strategy; in particular, they illustrate the importance of how specific rather than ad valorem taxes can reduce the potential for downward brand switching in the face of decreasing cigarette affordability. PMID:24114563

Alcohol taxation policy in Thailand: implications for other low- to middle-income countries.

PubMed

Sornpaisarn, Bundit; Shield, Kevin D; Rehm, Jürgen

2012-08-01

  Prevention of drinking initiation is a significant challenge in low- and middle-income countries that have a high prevalence of abstainers, including life-time abstainers. This paper aims to encourage a debate on an alternative alcohol taxation approach used currently in Thailand, which aims specifically to prevent drinking initiation in addition to reduce alcohol-attributable harms.   Theoretical evaluation, simulation and empirical analysis.   The taxation method of Thailand, 'Two-Chosen-One' (2C1) combines specific taxation (as a function of the alcohol content) and ad valorem taxation (as a function of the price), resulting in an effective tax rate that puts a higher tax both on beverages which are preferred by heavy drinkers and on beverages which are preferred by potential alcohol consumption neophytes, compared to either taxation system alone. As a result of these unique properties of the 2C1 taxation system, our simulations indicate that 2C1 taxation leads to a lower overall consumption than ad valorem or specific taxation alone. In addition, it puts a relatively high tax on beverages attractive to young people, the majority of whom are currently abstaining. Currently, the abstention rates in Thailand are higher than expected based on its economic wealth, which could be taken as an indication that the taxation strategy is successful.   'Two-chosen-one' (2C1) taxation has the potential to simultaneously reduce alcohol consumption and prevent drinking initiation among youth; however, additional empirical evidence is needed to assess its effectiveness in terms of the public health impact in low- and middle-income countries. © 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.

Changing demographics and state fiscal outlook: the case of sales taxes.

PubMed

Mullins, D R; Wallace, S

1996-04-01

"Broad-scale demographic changes have implications for state and local finance in terms of the composition of the base of revenue sources and their yields. This article examines the effect of such changes on the potential future yield of consumption-based taxes. The effect of household characteristics and composition on the consumption of selected groups of goods subject to ad valorem retail sales taxes is estimated, generating demographic elasticities of consumption. These elasticities are applied to projected demographic changes in eight states through the year 2000. The results show rather wide variation in expected consumption shifts and potential tax bases across the states, with income growth having the greatest effect...." The geographical focus is on the United States. excerpt

Introducing local property tax for fiscal decentralization and local authority autonomy

NASA Astrophysics Data System (ADS)

Dimopoulos, Thomas; Labropoulos, Tassos; Hadjimitsis, Diafantos G.

2015-06-01

Charles Tiebout (1956), in his work "A Pure Theory of Local Expenditures", provides a vision of the workings of the local public sector, acknowledging many similarities to the features of a competitive market, however omitting any references to local taxation. Contrary to other researchers' claim that the Tiebout model and the theory of fiscal decentralization are by no means synonymous, this paper aims to expand Tiebout's theory, by adding the local property tax in the context, introducing a fair, ad valorem property taxation system based on the automated assessment of the value of real estate properties within the boundaries of local authorities. Computer Assisted Mass Appraisal methodology integrated with Remote Sensing technology and GIS analysis is applied to local authorities' property registries and cadastral data, building a spatial relational database and providing data to be statistically processed through Multiple Regression Analysis modeling. The proposed scheme accomplishes economy of scale using CAMA procedures on one hand, but also succeeds in making local authorities self-sufficient through a decentralized, fair, locally calibrated property taxation model, providing rational income administration.

Do High Consumers of Sugar-Sweetened Beverages Respond Differently to Price Changes? A Finite Mixture IV-Tobit Approach.

PubMed

Etilé, Fabrice; Sharma, Anurag

2015-09-01

This study compares the impact of sugar-sweetened beverages (SSBs) tax between moderate and high consumers in Australia. The key methodological contribution is that price response heterogeneity is identified while controlling for censoring of consumption at zero and endogeneity of expenditure by using a finite mixture instrumental variable Tobit model. The SSB price elasticity estimates show a decreasing trend across increasing consumption quantiles, from -2.3 at the median to -0.2 at the 95th quantile. Although high consumers of SSBs have a less elastic demand for SSBs, their very high consumption levels imply that a tax would achieve higher reduction in consumption and higher health gains. Our results also suggest that an SSB tax would represent a small fiscal burden for consumers whatever their pre-policy level of consumption, and that an excise tax should be preferred to an ad valorem tax. Copyright © 2015 John Wiley & Sons, Ltd.

Mandatory labels, taxes and market forces: An empirical evaluation of fat policies.

PubMed

Allais, Olivier; Etilé, Fabrice; Lecocq, Sébastien

2015-09-01

The public-health community views mandatory Front-of-Pack (FOP) nutrition labels and nutritional taxes as promising tools to control the growth of food-related chronic diseases. This paper uses household scanner data to propose an ex-ante evaluation and comparison of these two policy options for the fromage blanc and dessert yogurt market. In most markets, labelling is voluntary and firms display fat labels only on the FOP of low-fat products to target consumers who do not want to eat fat. We here separately identify consumer preferences for fat and for FOP fat labels by exploiting an exogenous difference in legal labelling requirements between these two product categories. Estimates of demand curves are combined with a supply model of oligopolistic price competition to simulate policies. We find that a feasible ad valorem fat tax dominates a mandatory FOP-label policy from an economic perspective, but both are equally effective in reducing average fat purchases. Copyright © 2015 Elsevier B.V. All rights reserved.

Recent tobacco tax rate adjustment and its potential impact on tobacco control in China.

PubMed

Hu, Teh-Wei; Mao, Zhengzhong; Shi, Jian

2010-02-01

To compare the new tobacco tax structure effective from May 2009 with the tax structure before May 2009 and to analyse its potential impact. Published government statistics and estimated price elasticities of the demand for cigarettes are used to estimate the impact of the new tax rate adjustment on cigarette consumption and population health. The new adjustment increased the tax rate by 11.7% points at the producer price level. Converting this 11.7% point increase to the retail price level would mean an increase of 3.4% points in the retail price tax rate. Thus, China's new cigarette tax rate at the retail level would be 43.4% instead of the previous 40%. The primary motivation for the recent Chinese government tobacco tax adjustment is to raise additional government revenue. Because the additional ad valorem tax has not yet been transferred to smokers, there is no public health benefit. It is hoped that the Chinese government will pass along these taxes to the retail price level, which would result in between 640,000 and two million smokers quitting smoking and between 210,000 and 700,000 quitters avoiding smoking-related premature death.

Comparative analysis of property taxation policies within Greece and Cyprus evaluating the use of GIS, CAMA, and remote sensing techniques

NASA Astrophysics Data System (ADS)

Dimopoulos, Thomas; Labropoulos, Tassos; Hadjimitsis, Diofantos G.

2014-08-01

This paper aims to examine how CAMA, GIS and Remote Sensing are integrated to assist property taxation. Real property tax apart from its fiscal dimension is directly linked to geographic location. The value of the land and other immovable features such as buildings and structures is determined from specific parameters. All these immovable assets are visible and have specific geographic location & coordinates, materials, occupied area, land-use & utility, ownership & occupancy status and finally a specific value (ad valorem property taxation system) according to which the property tax is levied to taxpayers. Of high importance in the tax imposing procedure is that the use of CAMA, GIS and Remote Sensing tools is capable of providing effective and efficient collection of this property value determining data. Furthermore, these tools can track changes during a property's lifecycle such parcel subdivision into plots, demolition of a building and development of a new one or track a change in the planning zone. The integration of these systems also supports a full range of business processes on revenue mobilization ranging from billing to taxpayers objections management.

Spatial taxation effects on regional coal economic activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, C.W.; Labys, W.C.

1980-01-01

Spatial taxation effects related to economic activities at the regional level can be directly evaluated using the Kuhn-Tucker system of equations based on a commodity model. In particular, the impacts of a specific tax are predictable within a given set of trade patterns. However, the impacts of an ad valorem tax are difficult to evaluate analytically, mainly because of nonlinearity in the associated response surface. The aspect of spatial-taxation analysis of present relevance for the coal industry related to coal policy, i.e., the share of tax burdens coal producers and consumers are able to bear. Each supplier in a givenmore » market boundary shares the same amount of tax burden, which may eliminate the weakest coal producers, i.e., Southern West Virginia coal mines. The same analogy also applies to the weakest demand region, i.e., Illinois, Wisconsin, and Minnesota utilities. Consequently, a proper policy requires that some preferential tax treatment be given to these regions. Since the taxation effects depend critically on the trade patterns and market boundaries, the successful policy application of present regional energy models will not be possible unless effects of this type are included in the evaluation.« less

Correction of misleading information in prescription drug television advertising: The roles of advertisement similarity and time delay.

PubMed

Aikin, Kathryn J; Southwell, Brian G; Paquin, Ryan S; Rupert, Douglas J; O'Donoghue, Amie C; Betts, Kevin R; Lee, Philip K

Prescription drug television advertisements containing potentially consequential misinformation sometimes appear in the United States. When that happens, the U.S. Food and Drug Administration can request that companies distribute corrective advertisements to address misinformation and inaccurate claims. Previous research has demonstrated effectiveness in corrective advertising for various products. The present article builds on that work with a randomized experimental study (n = 6454) of corrective advertising investigating the extent to which visual similarity matters between violative and corrective ads and the extent to which time delay matters between violative and corrective advertisement exposure. Our study sample included overweight or obese U.S. adults recruited from an existing online consumer panel representative of the U.S. adult population. We created a brand for a fictitious prescription weight-loss drug and produced corresponding direct-to-consumer (DTC) television ads. All participants viewed the same violative ad, but were randomly assigned to view corrective ads with different levels of visual similarity and exposure time delay using a 4 × 4 between-subjects factorial design. Results suggest corrective ad exposure can influence consumer perceptions of drug efficacy, risks, and benefits previously established by violative ads that overstated drug efficacy, broadened drug indication, and omitted important risk information. Corrective ads also can weaken consumer intentions to consider and investigate a drug. However, ad similarity does not appear to affect consumer perceptions and preferences. Although we found that the effects of violative ad exposure tend to diminish over time, the length of the delay between violative and corrective ad exposure has limited influence. An exception to this was observed with regard to recall of drug benefits and risks, where the impact of corrective ad exposure increases with greater time delay. These results extend previous research to a new health condition and hold implications for regulatory policy. Published by Elsevier Inc.

77 FR 12307 - Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

..., corrective advertising is designed to dissipate or correct erroneous beliefs resulting from a false claim... how variations in corrective advertising may impact consumers' misleading product beliefs. III. Design... those who see only the original ad, only the corrective ad, and neither ad. Table 1--Design of Phase 1...

Holographic bulk reconstruction with α' corrections

NASA Astrophysics Data System (ADS)

Roy, Shubho R.; Sarkar, Debajyoti

2017-10-01

We outline a holographic recipe to reconstruct α' corrections to anti-de Sitter (AdS) (quantum) gravity from an underlying CFT in the strictly planar limit (N →∞ ). Assuming that the boundary CFT can be solved in principle to all orders of the 't Hooft coupling λ , for scalar primary operators, the λ-1 expansion of the conformal dimensions can be mapped to higher curvature corrections of the dual bulk scalar field action. Furthermore, for the metric perturbations in the bulk, the AdS /CFT operator-field isomorphism forces these corrections to be of the Lovelock type. We demonstrate this by reconstructing the coefficient of the leading Lovelock correction, also known as the Gauss-Bonnet term in a bulk AdS gravity action using the expression of stress-tensor two-point function up to subleading order in λ-1.

The recent and projected public health and economic benefits of cigarette taxation in Greece.

PubMed

Alpert, Hillel R; Vardavas, Constantine I; Chaloupka, Frank J; Vozikis, Athanassios; Athanasakis, Konstantinos; Kyriopoulos, Ioannis; Bertic, Monique; Behrakis, Panagiotis K; Connolly, Gregory N

2014-09-01

Greece is in an economic crisis compounded by the costs caused by smoking. The present investigation estimates the economic and public health benefits ensuing from the recent cigarette excise tax increase in 2011 and projects the potential benefits from an additional €2.00 per pack cigarette tax increase. The effects of the recent cigarette excise tax increase were calculated on outcome measures: total price per pack, including specific excise, ad valorem tax, and value-added tax consumption; tax revenue; and per capita consumption of cigarettes. Additionally, smoking-attributable mortality, years of potential life lost, and productivity losses were estimated. Projected effects of an additional €2.00 per pack tax increase on consumption and tax revenue were also assessed. The cigarette excise tax increase in 2011 created €558 million in new tax revenue. Cigarette consumption reached a recent low of 24.9 billion sticks sold or 2197 sticks per person in 2011, indicating a 16% decrease in per capita cigarette consumption from the previous year. An additional €2.00 per pack increase in Greek cigarette taxes is projected to result in reduced cigarette sales by an additional 20% and lead to an increase in total cigarette tax revenues by nearly €1.2 billion and the prevention of 192,000 premature deaths. Nations such as Greece, should employ taxation as a crucial measure to promote public health and economic development in such dire times. International economic organisations should aggressively pursue programmes and policies that champion the economic benefits of tobacco taxation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Association between tax structure and cigarette consumption: findings from the International Tobacco Control Policy Evaluation (ITC) Project.

PubMed

Shang, Ce; Lee, Hye Myung; Chaloupka, Frank J; Fong, Geoffrey T; Thompson, Mary; O'Connor, Richard J

2018-05-24

Recent studies show that greater price variability and more opportunities for tax avoidance are associated with tax structures that depart from a specific uniform one. These findings indicate that tax structures other than a specific uniform one may lead to more cigarette consumption. This paper aims to examine how cigarette tax structure is associated with cigarette consumption. We used survey data taken from the International Tobacco Control Policy Evaluation Project in 17 countries to conduct the analysis. Self-reported cigarette consumption was aggregated to average measures for each surveyed country and wave. The effect of tax structures on cigarette consumption was estimated using generalised estimating equations after adjusting for sociodemographic characteristics, average taxes and year fixed effects. Our study provides important empirical evidence of a relationship between tax structure and cigarette consumption. We find that a change from a specific to an ad valorem structure is associated with a 6%-11% higher cigarette consumption. In addition, a change from uniform to tiered structure is associated with a 34%-65% higher cigarette consumption. The results are consistent with existing evidence and suggest that a uniform and specific tax structure is the most effective tax structure for reducing tobacco consumption. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Sanctions, Smuggling, and the Cigarette: The Granting of Iran Office of Foreign Asset Control's Licenses to Big Tobacco.

PubMed

Batmanghelidj, Esfandyar; Heydari, Gholamreza

2014-02-01

Presuming that tobacco taxes, levied both as import duties and ad valorem, would financially benefit the Iranian Government, such the introduction of a highly desired US product to the market would be antithetical to the sanctions regime currently in place. This paper as a systematic review and documents through Pubmed and webs seeks to understand the politician economy implications of nicotine addiction in Iran, focusing on the US office of foreign asset control's (OFAC) awarding of Iran operations licenses to American tobacco companies. By comparing Iran's tobacco industry and the attendant public health crisis that has arisen from high rates of nicotine addiction, to conditions in Turkey, it can be demonstrated that Iran is uniquely unable to extract revenues from the sale of tobacco products. The primary point of comparison between Iran and Turkey is smoking-attributable annual productivity loses of each country as estimated through the use of smoking-attributable mortality, morbidity and economic costs software (SAMMEC) and the available related literature. Based on the calculations derived from the SAMMEC model, Iran is burdened with an incredible cost to the economy borne by a high prevalence of smokers. It is concluded that an awareness of this condition enables OFAC to award licenses to big tobacco without fear of undermining current foreign policy initiatives.

Sanctions, Smuggling, and the Cigarette: The Granting of Iran Office of Foreign Asset Control's Licenses to Big Tobacco

PubMed Central

Batmanghelidj, Esfandyar; Heydari, Gholamreza

2014-01-01

Background: Presuming that tobacco taxes, levied both as import duties and ad valorem, would financially benefit the Iranian Government, such the introduction of a highly desired US product to the market would be antithetical to the sanctions regime currently in place. Methods: This paper as a systematic review and documents through Pubmed and webs seeks to understand the politician economy implications of nicotine addiction in Iran, focusing on the US office of foreign asset control's (OFAC) awarding of Iran operations licenses to American tobacco companies. Results: By comparing Iran's tobacco industry and the attendant public health crisis that has arisen from high rates of nicotine addiction, to conditions in Turkey, it can be demonstrated that Iran is uniquely unable to extract revenues from the sale of tobacco products. The primary point of comparison between Iran and Turkey is smoking-attributable annual productivity loses of each country as estimated through the use of smoking-attributable mortality, morbidity and economic costs software (SAMMEC) and the available related literature. Based on the calculations derived from the SAMMEC model, Iran is burdened with an incredible cost to the economy borne by a high prevalence of smokers. Conclusions: It is concluded that an awareness of this condition enables OFAC to award licenses to big tobacco without fear of undermining current foreign policy initiatives. PMID:24627738

Bulk locality and quantum error correction in AdS/CFT

NASA Astrophysics Data System (ADS)

Almheiri, Ahmed; Dong, Xi; Harlow, Daniel

2015-04-01

We point out a connection between the emergence of bulk locality in AdS/CFT and the theory of quantum error correction. Bulk notions such as Bogoliubov transformations, location in the radial direction, and the holographic entropy bound all have natural CFT interpretations in the language of quantum error correction. We also show that the question of whether bulk operator reconstruction works only in the causal wedge or all the way to the extremal surface is related to the question of whether or not the quantum error correcting code realized by AdS/CFT is also a "quantum secret sharing scheme", and suggest a tensor network calculation that may settle the issue. Interestingly, the version of quantum error correction which is best suited to our analysis is the somewhat nonstandard "operator algebra quantum error correction" of Beny, Kempf, and Kribs. Our proposal gives a precise formulation of the idea of "subregion-subregion" duality in AdS/CFT, and clarifies the limits of its validity.

78 FR 60679 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... Company Model 717-200 airplanes. This AD was prompted by multiple reports of cracks of overwing frames. This AD requires repetitive inspections for cracking of the overwing frames, and corrective actions if necessary. We are issuing this AD to detect and correct such cracking that could sever a frame, which may...

One-Loop Test of Quantum Black Holes in anti–de Sitter Space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, James T.; Pando Zayas, Leopoldo A.; Rathee, Vimal

Within 11-dimensional supergravity we compute the logarithmic correction to the entropy of magnetically charged asymptotically AdS4 black holes with arbitrary horizon topology. We find perfect agreement with the expected microscopic result arising from the dual field theory computation of the topologically twisted index. Our result relies crucially on a particular limit to the extremal black hole case and clarifies some aspects of quantum corrections in asymptotically AdS spacetimes.

One-Loop Test of Quantum Black Holes in anti–de Sitter Space

DOE PAGES

Liu, James T.; Pando Zayas, Leopoldo A.; Rathee, Vimal; ...

2018-06-01

Within 11-dimensional supergravity we compute the logarithmic correction to the entropy of magnetically charged asymptotically AdS4 black holes with arbitrary horizon topology. We find perfect agreement with the expected microscopic result arising from the dual field theory computation of the topologically twisted index. Our result relies crucially on a particular limit to the extremal black hole case and clarifies some aspects of quantum corrections in asymptotically AdS spacetimes.

One-Loop Test of Quantum Black Holes in anti-de Sitter Space

NASA Astrophysics Data System (ADS)

Liu, James T.; Pando Zayas, Leopoldo A.; Rathee, Vimal; Zhao, Wenli

2018-06-01

Within 11-dimensional supergravity we compute the logarithmic correction to the entropy of magnetically charged asymptotically AdS4 black holes with arbitrary horizon topology. We find perfect agreement with the expected microscopic result arising from the dual field theory computation of the topologically twisted index. Our result relies crucially on a particular limit to the extremal black hole case and clarifies some aspects of quantum corrections in asymptotically AdS spacetimes.

Logarithmic corrections to entropy of magnetically charged AdS4 black holes

NASA Astrophysics Data System (ADS)

Jeon, Imtak; Lal, Shailesh

2017-11-01

Logarithmic terms are quantum corrections to black hole entropy determined completely from classical data, thus providing a strong check for candidate theories of quantum gravity purely from physics in the infrared. We compute these terms in the entropy associated to the horizon of a magnetically charged extremal black hole in AdS4×S7 using the quantum entropy function and discuss the possibility of matching against recently derived microscopic expressions.

One-Loop Test of Quantum Black Holes in anti-de Sitter Space.

PubMed

Liu, James T; Pando Zayas, Leopoldo A; Rathee, Vimal; Zhao, Wenli

2018-06-01

Within 11-dimensional supergravity we compute the logarithmic correction to the entropy of magnetically charged asymptotically AdS_{4} black holes with arbitrary horizon topology. We find perfect agreement with the expected microscopic result arising from the dual field theory computation of the topologically twisted index. Our result relies crucially on a particular limit to the extremal black hole case and clarifies some aspects of quantum corrections in asymptotically AdS spacetimes.

76 FR 11324 - Airworthiness Directives; Allied Ag Cat Productions, Inc. Models G-164, G-164A, G-164B, G-164B...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... rudder assembly for corrosion, taking necessary corrective action if corrosion is found, and applying corrosion protection. This AD retains the requirements of the previous AD and changes the compliance time.... We are issuing this AD to detect and correct corrosion in the rudder main tubular spar, which could...

Cigarette price level and variation in five Southeast Asian countries.

PubMed

Liber, Alex C; Ross, Hana; Ratanachena, Sophapan; Dorotheo, E Ulysses; Foong, Kin

2015-06-01

To monitor and analyse impacts of the interaction between tobacco excise tax policy and industry price strategy, on the price level and variation of cigarettes sold in five Southeast Asian countries (Indonesia, Cambodia, Lao PDR, the Philippines and Vietnam). Prices of cigarette sold by sticks and packs were collected through an in-person survey of retailers during 2011. Mean cigarette prices and price variation were calculated in each study country for single cigarettes, whole packs and brand groups. Price variation of whole packs was greater in countries with ad-valorem excise tax structures (Cambodia, Lao PDR and Vietnam) than in countries with multitiered specific excise taxes (Indonesia and the Philippines). The price variation for single sticks appeared to be driven by local currency denomination. Cigarettes sold individually cost more per stick than cigarettes sold in whole packs in every brand group except for Indonesia's domestic brands. Tobacco industry strategy and excise tax structure drove the price level and variation of cigarettes sold in packs, while currency denominations influence the selling price of single sticks. To maximise the effectiveness of tobacco tax policies, countries should adopt specific excise tax structures to decrease cigarette price variation, which would minimise opportunities for smokers to 'trade down' to a cheaper brand to avoid a tax-driven price increase. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Generalized Entanglement Entropy and Holography

NASA Astrophysics Data System (ADS)

Obregón, O.

2018-04-01

A nonextensive statistical mechanics entropy that depends only on the probability distribution is proposed in the framework of superstatistics. It is based on a Γ(χ 2) distribution that depends on β and also on pl . The corresponding modified von Neumann entropy is constructed; it is shown that it can also be obtained from a generalized Replica trick. We address the question whether the generalized entanglement entropy can play a role in the gauge/gravity duality. We pay attention to 2dCFT and their gravity duals. The correction terms to the von Neumann entropy result more relevant than the usual UV (for c = 1) ones and also than those due to the area dependent AdS 3 entropy which result comparable to the UV ones. Then the correction terms due to the new entropy would modify the Ryu-Takayanagi identification between the CFT entanglement entropy and the AdS entropy in a different manner than the UV ones or than the corrections to the AdS 3 area dependent entropy.

75 FR 1527 - Airworthiness Directives; The Boeing Company Model 737-300, -400, and -500 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-12

... subsequent deployment of the oxygen masks. We are issuing this AD to detect and correct fatigue cracking of... deployment of the oxygen masks. We are issuing this AD to detect and correct fatigue cracking of the fuselage...

Quantum corrections to Bekenstein-Hawking black hole entropy and gravity partition functions

NASA Astrophysics Data System (ADS)

Bytsenko, A. A.; Tureanu, A.

2013-08-01

Algebraic aspects of the computation of partition functions for quantum gravity and black holes in AdS3 are discussed. We compute the sub-leading quantum corrections to the Bekenstein-Hawking entropy. It is shown that the quantum corrections to the classical result can be included systematically by making use of the comparison with conformal field theory partition functions, via the AdS3/CFT2 correspondence. This leads to a better understanding of the role of modular and spectral functions, from the point of view of the representation theory of infinite-dimensional Lie algebras. Besides, the sum of known quantum contributions to the partition function can be presented in a closed form, involving the Patterson-Selberg spectral function. These contributions can be reproduced in a holomorphically factorized theory whose partition functions are associated with the formal characters of the Virasoro modules. We propose a spectral function formulation for quantum corrections to the elliptic genus from supergravity states.

The efficacy of sugar labeling formats: Implications for labeling policy.

PubMed

Vanderlee, Lana; White, Christine M; Bordes, Isabelle; Hobin, Erin P; Hammond, David

2015-12-01

To examine knowledge of sugar recommendations and test the efficacy of formats for labeling total and added sugar on pre-packaged foods. Online surveys were conducted among 2008 Canadians aged 16-24. Participants were asked to identify recommended limits for total and added sugar consumption. In Experiment 1, participants were randomized to one of six labeling conditions with varying information for total sugar for a high- or low-sugar product and were asked to identify the relative amount of total sugar in the product. In Experiment 2, participants were randomized to one of three labels with different added sugar formats and were asked if the product contained added sugar and the relative amount of added sugar. Few young people correctly identified recommendations for total sugar (5%) or added sugar (7%). In Experiment 1, those who were shown percent daily value information were more likely to correctly identify the relative amount of total sugar (P < 0.05). In Experiment 2, those shown added sugar information were more likely to correctly identify that the product contained added sugar and the relative amount of added sugar in the product (P < 0.05). Improved labeling may improve consumer understanding of the amount of sugars in food products. © 2015 The Obesity Society.

Usefulness of 3-dimensional stereotactic surface projection FDG PET images for the diagnosis of dementia

PubMed Central

Kim, Jahae; Cho, Sang-Geon; Song, Minchul; Kang, Sae-Ryung; Kwon, Seong Young; Choi, Kang-Ho; Choi, Seong-Min; Kim, Byeong-Chae; Song, Ho-Chun

2016-01-01

Abstract To compare diagnostic performance and confidence of a standard visual reading and combined 3-dimensional stereotactic surface projection (3D-SSP) results to discriminate between Alzheimer disease (AD)/mild cognitive impairment (MCI), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). [18F]fluorodeoxyglucose (FDG) PET brain images were obtained from 120 patients (64 AD/MCI, 38 DLB, and 18 FTD) who were clinically confirmed over 2 years follow-up. Three nuclear medicine physicians performed the diagnosis and rated diagnostic confidence twice; once by standard visual methods, and once by adding of 3D-SSP. Diagnostic performance and confidence were compared between the 2 methods. 3D-SSP showed higher sensitivity, specificity, accuracy, positive, and negative predictive values to discriminate different types of dementia compared with the visual method alone, except for AD/MCI specificity and FTD sensitivity. Correction of misdiagnosis after adding 3D-SSP images was greatest for AD/MCI (56%), followed by DLB (13%) and FTD (11%). Diagnostic confidence also increased in DLB (visual: 3.2; 3D-SSP: 4.1; P < 0.001), followed by AD/MCI (visual: 3.1; 3D-SSP: 3.8; P = 0.002) and FTD (visual: 3.5; 3D-SSP: 4.2; P = 0.022). Overall, 154/360 (43%) cases had a corrected misdiagnosis or improved diagnostic confidence for the correct diagnosis. The addition of 3D-SSP images to visual analysis helped to discriminate different types of dementia in FDG PET scans, by correcting misdiagnoses and enhancing diagnostic confidence in the correct diagnosis. Improvement of diagnostic accuracy and confidence by 3D-SSP images might help to determine the cause of dementia and appropriate treatment. PMID:27930593

78 FR 49232 - Airworthiness Directives; Learjet Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

... tube is installed; and follow-on/corrective actions, as applicable. Since we issued that AD, we have... AD, and would require determining if a certain fuel crossflow tube is installed, performing repetitive measurements of the fuel crossflow tube and surrounding valves and cables, and doing corrective...

77 FR 46932 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-07

... Company Model 767 airplanes. This AD was prompted by reports of cracks of the underwing longeron fittings... for cracking, and related investigative and corrective actions if necessary. We are issuing this AD to detect and correct such cracking, which could result in loss of the primary load path between the...

77 FR 42625 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-1412; Directorate Identifier 2011-NM-158-AD; Amendment 39-17088; AD 2012-12-08] RIN 2120-AA64... 37781-37783 in the issue of Monday, June 25, 2012 make the following correction: Sec. 39.13 [Corrected...

78 FR 8999 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

...-400 series airplanes. This proposed AD was prompted by reports of auxiliary power unit (APU) faults... the APU power feeder cables; replacing the clamps and installing grommets; and related investigative and corrective actions if necessary. We are proposing this AD to detect and correct chafing of the APU...

78 FR 23694 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

... track of the inboard flap. This proposed AD would require repetitive inspections of the forward support fitting assemblies of the inboard track of the left and right inboard flaps for cracking, and corrective actions if necessary. We are proposing this AD to detect and correct cracking of the forward support...

75 FR 39472 - Airworthiness Directives; Eclipse Aerospace, Inc. Model EA500 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-09

..., altitude preselect, and/or transponder codes. We are proposing this AD to correct faulty integration of... determined to be a software communication integration issue between the EFIS display interface and associated... transponder codes. We are issuing this AD to correct faulty integration of hardware and software, which could...

78 FR 71989 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... forward engine mount, and related investigative and corrective actions if necessary. This AD was prompted by a report of cracked barrel nuts found on a forward engine mount. We are issuing this AD to detect and correct cracked barrel nuts on a forward engine mount, which could result in reduced load capacity...

Estimated Effects of Different Alcohol Taxation and Price Policies on Health Inequalities: A Mathematical Modelling Study.

PubMed

Meier, Petra S; Holmes, John; Angus, Colin; Ally, Abdallah K; Meng, Yang; Brennan, Alan

2016-02-01

While evidence that alcohol pricing policies reduce alcohol-related health harm is robust, and alcohol taxation increases are a WHO "best buy" intervention, there is a lack of research comparing the scale and distribution across society of health impacts arising from alternative tax and price policy options. The aim of this study is to test whether four common alcohol taxation and pricing strategies differ in their impact on health inequalities. An econometric epidemiological model was built with England 2014/2015 as the setting. Four pricing strategies implemented on top of the current tax were equalised to give the same 4.3% population-wide reduction in total alcohol-related mortality: current tax increase, a 13.4% all-product duty increase under the current UK system; a value-based tax, a 4.0% ad valorem tax based on product price; a strength-based tax, a volumetric tax of £0.22 per UK alcohol unit (= 8 g of ethanol); and minimum unit pricing, a minimum price threshold of £0.50 per unit, below which alcohol cannot be sold. Model inputs were calculated by combining data from representative household surveys on alcohol purchasing and consumption, administrative and healthcare data on 43 alcohol-attributable diseases, and published price elasticities and relative risk functions. Outcomes were annual per capita consumption, consumer spending, and alcohol-related deaths. Uncertainty was assessed via partial probabilistic sensitivity analysis (PSA) and scenario analysis. The pricing strategies differ as to how effects are distributed across the population, and, from a public health perspective, heavy drinkers in routine/manual occupations are a key group as they are at greatest risk of health harm from their drinking. Strength-based taxation and minimum unit pricing would have greater effects on mortality among drinkers in routine/manual occupations (particularly for heavy drinkers, where the estimated policy effects on mortality rates are as follows: current tax increase, -3.2%; value-based tax, -2.9%; strength-based tax, -6.1%; minimum unit pricing, -7.8%) and lesser impacts among drinkers in professional/managerial occupations (for heavy drinkers: current tax increase, -1.3%; value-based tax, -1.4%; strength-based tax, +0.2%; minimum unit pricing, +0.8%). Results from the PSA give slightly greater mean effects for both the routine/manual (current tax increase, -3.6% [95% uncertainty interval (UI) -6.1%, -0.6%]; value-based tax, -3.3% [UI -5.1%, -1.7%]; strength-based tax, -7.5% [UI -13.7%, -3.9%]; minimum unit pricing, -10.3% [UI -10.3%, -7.0%]) and professional/managerial occupation groups (current tax increase, -1.8% [UI -4.7%, +1.6%]; value-based tax, -1.9% [UI -3.6%, +0.4%]; strength-based tax, -0.8% [UI -6.9%, +4.0%]; minimum unit pricing, -0.7% [UI -5.6%, +3.6%]). Impacts of price changes on moderate drinkers were small regardless of income or socioeconomic group. Analysis of uncertainty shows that the relative effectiveness of the four policies is fairly stable, although uncertainty in the absolute scale of effects exists. Volumetric taxation and minimum unit pricing consistently outperform increasing the current tax or adding an ad valorem tax in terms of reducing mortality among the heaviest drinkers and reducing alcohol-related health inequalities (e.g., in the routine/manual occupation group, volumetric taxation reduces deaths more than increasing the current tax in 26 out of 30 probabilistic runs, minimum unit pricing reduces deaths more than volumetric tax in 21 out of 30 runs, and minimum unit pricing reduces deaths more than increasing the current tax in 30 out of 30 runs). Study limitations include reducing model complexity by not considering a largely ineffective ban on below-tax alcohol sales, special duty rates covering only small shares of the market, and the impact of tax fraud or retailer non-compliance with minimum unit prices. Our model estimates that, compared to tax increases under the current system or introducing taxation based on product value, alcohol-content-based taxation or minimum unit pricing would lead to larger reductions in health inequalities across income groups. We also estimate that alcohol-content-based taxation and minimum unit pricing would have the largest impact on harmful drinking, with minimal effects on those drinking in moderation.

The Association between Tax Structure and Cigarette Price Variability: Findings from the International Tobacco Control Policy Evaluation (ITC) Project

PubMed Central

Shang, Ce; Chaloupka, Frank J.; Fong, Geoffrey T; Thompson, Mary; O’Connor, Richard J

2015-01-01

Background Recent studies have shown that more opportunities exist for tax avoidance when cigarette excise tax structure departs from a uniform specific structure. However, the association between tax structure and cigarette price variability has not been thoroughly studied in the existing literature. Objective To examine how cigarette tax structure is associated with price variability. The variability of self-reported prices is measured using the ratios of differences between higher and lower prices to the median price such as the IQR-to-median ratio. Methods We used survey data taken from the International Tobacco Control Policy Evaluation (ITC) Project in 17 countries to conduct the analysis. Cigarette prices were derived using individual purchase information and aggregated to price variability measures for each surveyed country and wave. The effect of tax structures on price variability was estimated using Generalised Estimating Equations after adjusting for year and country attributes. Findings Our study provides empirical evidence of a relationship between tax structure and cigarette price variability. We find that, compared to the specific uniform tax structure, mixed uniform and tiered (specific, ad valorem or mixed) structures are associated with greater price variability (p≤0.01). Moreover, while a greater share of the specific component in total excise taxes is associated with lower price variability (p≤0.05), a tiered tax structure is associated with greater price variability (p≤0.01). The results suggest that a uniform and specific tax structure is the most effective tax structure for reducing tobacco consumption and prevalence by limiting price variability and decreasing opportunities for tax avoidance. PMID:25855641

Alcohol taxes' contribution to prices in high and middle-income countries: Data from the International Alcohol Control Study.

PubMed

Wall, Martin; Casswell, Sally; Callinan, Sarah; Chaiyasong, Surasak; Viet Cuong, Pham; Gray-Phillip, Gaile; Parry, Charles

2017-11-22

Taxation is increasingly being used as an effective means of influencing behaviour in relation to harmful products. In this paper we use data from six participating countries of the International Alcohol Control Study to examine and evaluate their comparative prices and tax regimes. We calculate taxes and prices for three high-income and three middle-income countries. The data are drawn from the International Alcohol Control survey and from the Alcohol Environment Protocol. Tax systems are described and then the rates of tax on key products presented. Comparisons are made using the Purchasing Power Parity rates. The price and purchase data from each country's International Alcohol Control survey is then used to calculate the mean percentage of retail price paid in tax weighted by actual consumption. Both ad valorem and specific per unit of alcohol taxation systems are represented among the six countries. The prices differ widely between countries even though presented in terms of Purchasing Power Parity. The percentage of tax in the final price also varies widely but is much lower than the 75% set by the World Health Organization as a goal for tobacco tax. There is considerable variation in tax systems and prices across countries. There is scope to increase taxation and this analysis provides comparable data, including the percentage of tax in final price, from some middle and high-income countries for consideration in policy discussion. © 2017 The Authors Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs.

Smokeless tobacco product prices and taxation in Bangladesh: findings from the International Tobacco Control Survey.

PubMed

Nargis, N; Hussain, A K M G; Fong, G T

2014-12-01

Smokeless tobacco use occupies a significant portion of overall tobacco consumption in Bangladesh. Yet very little is known about the effectiveness of tax and price policy in controlling the use of smokeless tobacco use in the country. The paper examines the price distribution of various smoked (cigarette, bidi) and smokeless tobacco products (zarda, gul) using the univariate Epanechnikov kernel density function. It estimates the own and cross price elasticity of demand for the most widely used smokeless tobacco product zarda using two-step regression analysis. The analysis is based on data from the ITC Bangladesh Wave 3 Survey which is a nationally representative cohort survey of tobacco users and nonusers conducted in in Bangladesh during 2011-12. The price elasticity of lower price brands of zarda is estimated at -0.64 and of higher priced brands at -0.39, and the cross price elasticity of zarda with respect to cigarette price at 0.35. The tax increase on smokeless tobacco needs to be greater than the tax increase on smoked tobacco to bridge the wide price differential between the two types of products that currently encourages downward substitution from smoked to smokeless tobacco and discourages quitting behavior. This paper argues that increasing tax on smokeless tobacco simultaneously with the tax increase on smoked tobacco can have significant negative impact on the prevalence of smokeless tobacco use in Bangladesh. Finally, a specific excise system replacing the existing ad valorem excise tax can substantially contribute to the revenue collection performance from smokeless tobacco products.

The impact of a sugar-sweetened beverages tax on oral health and costs of dental care in Australia.

PubMed

Sowa, P Marcin; Keller, Elena; Stormon, Nicole; Lalloo, Ratilal; Ford, Pauline J

2018-05-22

Despite a clear causal link between frequent consumption of sugar-sweetened beverages (SSBs) and dental disease, little is known about the implications of a tax on SSBs in the context of oral health. The aim of our study was to estimate the impacts of a SSB tax on the Australian population in the context of oral health outcomes, dental care utilisation and associated costs. We designed a cohort model that accounted for the consequences of the tax through the mechanisms of consumer response to price increase, the effect on oral health due to change in sugar intake, and the implications for dental care use. Our results indicate that in the adult population an ad valorem tax of 20% would lead to a reduction in decayed, missing and filled teeth (DMFT) by 3.9 million units over 10 years, resulting in cost savings of A$666 million. Scenario analyses show that the outcomes are sensitive to the choice of the time horizon, tax rate, price elasticity of demand for SSBs, and the definition of target population. We found that the total and per-person consequences of SSB tax were considerable, both in terms of dental caries (tooth decay) averted and dental care avoided. These results have to be compounded with the implications of SSB tax for other aspects of health and health care, especially in the context of chronic diseases. On the other hand, the improved outcomes have to be weighted against a welfare loss associated with introducing a tax.

75 FR 6154 - Airworthiness Directives; The Boeing Company Model 767 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... to include the vertical inner chord at STA 1809.5. This proposed AD results from reported fatigue... horizontal inner chord at STA 1809.5. We are proposing this AD to detect and correct fatigue cracking in the... and correct fatigue cracking in the bulkhead structure at station (STA) 1809.5 and the vertical inner...

Three dimensional view of the SYK/AdS duality

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, Sumit R.; Jevicki, Antal; Suzuki, Kenta

2017-09-05

We show that the spectrum of the SYK model can be interpreted as that of a 3D scalar coupled to gravity. The scalar has a mass which is at the Breitenholer-Freedman bound of AdS 2, and subject to a delta function potential at the center of the interval along the third direction. This, through Kaluza-Klein procedure on AdS 2 × (S 1)/Z 2, generates the spectrum reproducing the bi-local propagator at strong coupling. Furthermore, the leading 1/J correction calculated in this picture reproduces the known correction to the poles of the SYK propagator, providing credence to a conjecture that themore » bulk dual of this model can be interpreted as a three dimensional theory.« less

Non-equilibrium condensation process in holographic superconductor with nonlinear electrodynamics

NASA Astrophysics Data System (ADS)

Liu, Yunqi; Gong, Yungui; Wang, Bin

2016-02-01

We study the non-equilibrium condensation process in a holographic superconductor with nonlinear corrections to the U (1) gauge field. We start with an asymptotic Anti-de-Sitter (AdS) black hole against a complex scalar perturbation at the initial time, and solve the dynamics of the gravitational systems in the bulk. When the black hole temperature T is smaller than a critical value T c , the scalar perturbation grows exponentially till saturation, the final state of spacetime approaches to a hairy black hole. In the bulk theory, we find the clue of the influence of nonlinear corrections in the gauge filed on the process of the scalar field condensation. We show that the bulk dynamics in the non-equilibrium process is completely consistent with the observations on the boundary order parameter. Furthermore we examine the time evolution of horizons in the bulk non-equilibrium transformation process from the bald AdS black hole to the AdS hairy hole. Both the evolution of apparent and event horizons show that the original AdS black hole configuration requires more time to finish the transformation to become a hairy black hole if there is nonlinear correction to the electromagnetic field. We generalize our non-equilibrium discussions to the holographic entanglement entropy and find that the holographic entanglement entropy can give us further understanding of the influence of the nonlinearity in the gauge field on the scalar condensation.

Semiclassical Virasoro blocks from AdS 3 gravity

DOE PAGES

Hijano, Eliot; Kraus, Per; Perlmutter, Eric; ...

2015-12-14

We present a unified framework for the holographic computation of Virasoro conformal blocks at large central charge. In particular, we provide bulk constructions that correctly reproduce all semiclassical Virasoro blocks that are known explicitly from conformal field theory computations. The results revolve around the use of geodesic Witten diagrams, recently introduced in [1], evaluated in locally AdS 3 geometries generated by backreaction of heavy operators. We also provide an alternative computation of the heavy-light semiclassical block — in which two external operators become parametrically heavy — as a certain scattering process involving higher spin gauge fields in AdS 3; thismore » approach highlights the chiral nature of Virasoro blocks. Finally, these techniques may be systematically extended to compute corrections to these blocks and to interpolate amongst the different semiclassical regimes.« less

Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model.

PubMed

Carradori, Dario; Balducci, Claudia; Re, Francesca; Brambilla, Davide; Le Droumaguet, Benjamin; Flores, Orfeu; Gaudin, Alice; Mura, Simona; Forloni, Gianluigi; Ordoñez-Gutierrez, Lara; Wandosell, Francisco; Masserini, Massimo; Couvreur, Patrick; Nicolas, Julien; Andrieux, Karine

2018-02-01

Alzheimer's disease (AD) is a neurodegenerative disorder related, in part, to the accumulation of amyloid-β peptide (Aβ) and especially the Aβ peptide 1-42 (Aβ 1-42 ). The aim of this study was to design nanocarriers able to: (i) interact with the Aβ 1-42 in the blood and promote its elimination through the "sink effect" and (ii) correct the memory defect observed in AD-like transgenic mice. To do so, biodegradable, PEGylated nanoparticles were surface-functionalized with an antibody directed against Aβ 1-42 . Treatment of AD-like transgenic mice with anti-Aβ 1-42 -functionalized nanoparticles led to: (i) complete correction of the memory defect; (ii) significant reduction of the Aβ soluble peptide and its oligomer level in the brain and (iii) significant increase of the Aβ levels in plasma. This study represents the first example of Aβ 1-42 monoclonal antibody-decorated nanoparticle-based therapy against AD leading to complete correction of the memory defect in an experimental model of AD. Copyright © 2017 Elsevier Inc. All rights reserved.

75 FR 1297 - Airworthiness Directives; Boeing Model 737-600, -700, -700C, -800, -900, and -900ER Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

... installed, one-time torquing of the nut and bolt, and corrective actions if necessary. This proposed AD... nut and bolt, and corrective actions if necessary. That AD resulted from reports of parts coming off... of the slat track hardware (i.e., the bolt, washers, downstops, stop location, and nut shown in...

76 FR 35327 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... stabilizer takeoff warning switches, and corrective actions if necessary. This AD was prompted by reports that the warning horn did not sound during the takeoff warning system test of the S132 ``nose up stab takeoff warning switch.'' We are issuing this AD to detect and correct a takeoff warning system switch...

75 FR 55691 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... takeoff warning switches, and corrective actions if necessary. This proposed AD results from reports that the warning horn did not sound during the takeoff warning system test of the S132 ``nose up stab takeoff warning switch.'' We are proposing this AD to detect and correct a takeoff warning system switch...

78 FR 79338 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

...We propose to adopt a new airworthiness directive (AD) for certain Bombardier, Inc. Model DHC-8-400 series airplanes. This proposed AD was prompted by reports of missing clamps that are required to provide positive separation between the alternating current (AC) feeder cables and the hydraulic line of the landing gear alternate extension. This proposed AD would require inspecting for missing clamps, and related investigative and corrective actions if necessary. We are proposing this AD to detect and correct chafing of the AC feeder cable. A chafed and arcing AC feeder cable could puncture the adjacent hydraulic line, which, in combination with the use of the alternate extension system, could result in an in-flight fire.

77 FR 31724 - Exchange Visitor Program-Summer Work Travel; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... DEPARTMENT OF STATE 22 CFR Part 62 RIN 1400-AD14 [Public Notice 7902] Exchange Visitor Program--Summer Work Travel; Correction AGENCY: Department of State. ACTION: Interim final rule; correction SUMMARY: This document contains minor corrections to the Exchange Visitor Program--Summer Work Travel...

77 FR 65099 - Use of the Centennial of Flight Commission Name; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-25

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Part 1204 [Docket No. NASA-2012-0004] RIN 2700-AD78 Use of the Centennial of Flight Commission Name; Correction AGENCY: National Aeronautics and Space Administration. ACTION: Direct final rule; correction. SUMMARY: This document corrects a direct...

Improving dementia health literacy using the FLOW mnemonic: pilot findings from the Old SCHOOL hip-hop program.

PubMed

Noble, James M; Hedmann, Monique G; Williams, Olajide

2015-02-01

Dementia health literacy is low among the public and likely poses a significant barrier to Alzheimer's disease (AD) symptom recognition and treatment, particularly among minority populations already facing higher AD burden. We evaluated the pilot phase of a novel AD health education program, Old SCHOOL (Seniors Can Have Optimal Aging and Ongoing Longevity) Hip-Hop (OSHH), which is designed to enable children to be AD health educational conduits in the home ("child-mediated health communication"). OSHH applied our stroke-validated model of engaging, dynamic, and age- and culturally appropriate curriculum delivered to elementary school-age children (fourth/fifth grades, ages 9-11 years). We assessed AD knowledge among the children at baseline, immediately following the intervention (1-hour program delivered daily over 3 consecutive days), and 3 months later. For key AD symptoms, we developed the FLOW mnemonic (forget, lose, overlook, write/wander); students were additionally taught action plans for recognized symptoms. Seventy-five students completed baseline assessments, and 68 completed posttesting. AD symptoms in FLOW were not well known at baseline (individually ranging from 16% to 71% correct) but were highly learned after 3 days (89% to 98% correct) and retained well after 3 months (80% to 95% correct, p ≤ .01 for all comparisons vs. baseline). AD localization, including its effect on memory and the hippocampus, was also highly learned and retained (p < .001). Eighteen students (24%) reported having a close friend/family member with AD. This study suggests our hip-hop health education model may be an effective method to improve AD health literacy. © 2014 Society for Public Health Education.

Smithsonian Astrophysical Observatory (SAO) star catalog (Sao staff 1966, edition ADC 1989): Documentation for the machine-readable version

NASA Technical Reports Server (NTRS)

Roman, Nancy G.; Warren, Wayne H., Jr.

1989-01-01

An updated, corrected, and extended machine readable version of the catalog is described. Published and unpublished errors discovered in the previous version were corrected, and multiple star and supplemental BD identifications were added to stars where more than one SAO entry has the same Durchmusterung number. Henry Draper Extension (HDE) numbers were added for stars found in both volumes of the extension. Data for duplicate SAO entries (those referring to the same star) were flagged. J2000 positions in usual units and in radians were added.

Loop corrections for Kaluza-Klein AdS amplitudes

NASA Astrophysics Data System (ADS)

Aprile, F.; Drummond, J. M.; Heslop, P.; Paul, H.

2018-05-01

Recently we conjectured the four-point amplitude of graviton multiplets in AdS5 × S5 at one loop by exploiting the operator product expansion of N = 4 super Yang-Mills theory. Here we give the first extension of those results to include Kaluza-Klein modes, obtaining the amplitude for two graviton multiplets and two states of the first KK mode. Our method again relies on resolving the large N degeneracy among a family of long double-trace operators, for which we obtain explicit formulas for the leading anomalous dimensions. Having constructed the one-loop amplitude we are able to obtain a formula for the one-loop corrections to the anomalous dimensions of all twist five double-trace operators.

Unitary reconstruction of secret for stabilizer-based quantum secret sharing

NASA Astrophysics Data System (ADS)

Matsumoto, Ryutaroh

2017-08-01

We propose a unitary procedure to reconstruct quantum secret for a quantum secret sharing scheme constructed from stabilizer quantum error-correcting codes. Erasure correcting procedures for stabilizer codes need to add missing shares for reconstruction of quantum secret, while unitary reconstruction procedures for certain class of quantum secret sharing are known to work without adding missing shares. The proposed procedure also works without adding missing shares.

76 FR 8294 - Technical Correction: Completion of Entry and Entry Summary-Declaration of Value; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... DEPARTMENT OF HOMELAND SECURITY U. S. Customs and Border Protection 19 CFR Part 141 [USCBP-2008-0062; CBP Dec. 10-34] RIN 1515-AD61 (Formerly 1505-AB96) Technical Correction: Completion of Entry and Entry Summary-- Declaration of Value; Correction AGENCY: Customs and Border Protection, Department of...

The effect of cigarette prices on brand-switching in China: a longitudinal analysis of data from the ITC China Survey

PubMed Central

White, Justin S; Li, Jing; Hu, Teh-wei; Fong, Geoffrey T; Jiang, Yuan

2014-01-01

Background Recent studies have found that Chinese smokers are relatively unresponsive to cigarette prices. As the Chinese government contemplates higher tobacco taxes, it is important to understand the reasons for this low response. One possible explanation is that smokers buffer themselves from rising cigarette prices by switching to cheaper cigarette brands. Objective This study examines how cigarette prices influence consumers’ choices of cigarette brands in China. Methods This study uses panel data from the first three waves of the International Tobacco Control China Survey, drawn from six large cities in China and collected between 2006 and 2009. The study sample includes 3477 smokers who are present in at least two waves (8552 person-years). Cigarette brands are sorted by price into four tiers, using excise tax categories to determine the cut-off for each tier. The analysis relies on a conditional logit model to identify the relationship between price and brand choice. Findings Overall, 38% of smokers switched price tiers from one wave to the next. A ¥1 change in the price of cigarettes alters the tier choice of 4–7% of smokers. Restricting the sample to those who chose each given tier at baseline, a ¥1 increase in price in a given tier would decrease the share choosing that tier by 4% for Tier 1 and 1–2% for Tiers 2 and 3. Conclusions China's large price spread across cigarette brands appears to alter the brand selection of some consumers, especially smokers of cheaper brands. Tobacco pricing and tax policy can influence consumers’ incentives to switch brands. In particular, whereas ad valorem taxes in a tiered pricing system like China's encourage trading down, specific excise taxes discourage the practice. PMID:23697645

Differential effects of green tax reform over economies: A case of Korea

NASA Astrophysics Data System (ADS)

Kim, Tae Heon

2011-12-01

It is controversial whether or not green tax reform through a carbon tax has double dividend feature. The economic effects of green tax reform vary according to economies due to different preexisting conditions. Recent studies about the economic impacts of a carbon tax have noted the role of preexisting factor taxes in the second best world. The present study, however, explores the role of existing taxes on energy products in introducing a carbon tax, by employing a computable general equilibrium (CGE) model for Korea, a country that has high existing taxes on petroleum products. Above all, I find that a carbon tax is the most efficient policy instrument among three alternative taxes---an energy tax, a carbon tax and an ad valorem tax---to reduce carbon emissions in Korea under both lump-sum tax replacement and labor tax replacement. The carbon tax, however, brings about welfare and GDP loss. The economic costs can be reduced, but cannot be completely removed by revenue recycling. Second, this study explores how existing taxes on petroleum products affect the economic cost of introducing a carbon tax, by manipulating existing taxes on petroleum products. I find that the existing taxes raise the economic costs of introducing a carbon tax. Third, this study shows that the economic costs of a carbon tax can be reduced when its revenue is returned to cut preexisting taxes on petroleum products. Thus, restructuring existing taxes on energy products plays a crucial role in introducing a carbon tax. From the specific case of the Korean economy, the present study indicates that existing taxes on not only factors but also energy products are one of the main sources of economic costs in introducing a carbon tax.

The association between tax structure and cigarette price variability: findings from the ITC Project.

PubMed

Shang, Ce; Chaloupka, Frank J; Fong, Geoffrey T; Thompson, Mary; O'Connor, Richard J

2015-07-01

Recent studies have shown that more opportunities exist for tax avoidance when cigarette excise tax structure departs from a uniform specific structure. However, the association between tax structure and cigarette price variability has not been thoroughly studied in the existing literature. To examine how cigarette tax structure is associated with price variability. The variability of self-reported prices is measured using the ratios of differences between higher and lower prices to the median price such as the IQR-to-median ratio. We used survey data taken from the International Tobacco Control Policy Evaluation (ITC) Project in 17 countries to conduct the analysis. Cigarette prices were derived using individual purchase information and aggregated to price variability measures for each surveyed country and wave. The effect of tax structures on price variability was estimated using Generalised Estimating Equations after adjusting for year and country attributes. Our study provides empirical evidence of a relationship between tax structure and cigarette price variability. We find that, compared to the specific uniform tax structure, mixed uniform and tiered (specific, ad valorem or mixed) structures are associated with greater price variability (p≤0.01). Moreover, while a greater share of the specific component in total excise taxes is associated with lower price variability (p≤0.05), a tiered tax structure is associated with greater price variability (p≤0.01). The results suggest that a uniform and specific tax structure is the most effective tax structure for reducing tobacco consumption and prevalence by limiting price variability and decreasing opportunities for tax avoidance. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Alzheimer's disease detection using 11C-PiB with improved partial volume effect correction

NASA Astrophysics Data System (ADS)

Raniga, Parnesh; Bourgeat, Pierrick; Fripp, Jurgen; Acosta, Oscar; Ourselin, Sebastien; Rowe, Christopher; Villemagne, Victor L.; Salvado, Olivier

2009-02-01

Despite the increasing use of 11C-PiB in research into Alzheimer's disease (AD), there are few standardized analysis procedures that have been reported or published. This is especially true with regards to partial volume effects (PVE) and partial volume correction. Due to the nature of PET physics and acquisition, PET images exhibit relatively low spatial resolution compared to other modalities, resulting in bias of quantitative results. Although previous studies have applied PVE correction techniques on 11C-PiB data, the results have not been quantitatively evaluated and compared against uncorrected data. The aim of this study is threefold. Firstly, a realistic synthetic phantom was created to quantify PVE. Secondly, MRI partial volume estimate segmentations were used to improve voxel-based PVE correction instead of using hard segmentations. Thirdly, quantification of PVE correction was evaluated on 34 subjects (AD=10, Normal Controls (NC)=24), including 12 PiB positive NC. Regional analysis was performed using the Anatomical Automatic Labeling (AAL) template, which was registered to each patient. Regions of interest were restricted to the gray matter (GM) defined by the MR segmentation. Average normalized intensity of the neocortex and selected regions were used to evaluate the discrimination power between AD and NC both with and without PVE correction. Receiver Operating Characteristic (ROC) curves were computed for the binary discrimination task. The phantom study revealed signal losses due to PVE between 10 to 40 % which were mostly recovered to within 5% after correction. Better classification was achieved after PVE correction, resulting in higher areas under ROC curves.

Comparative assessment of astigmatism-corrected Czerny-Turner imaging spectrometer using off-the-shelf optics

NASA Astrophysics Data System (ADS)

Yuan, Qun; Zhu, Dan; Chen, Yueyang; Guo, Zhenyan; Zuo, Chao; Gao, Zhishan

2017-04-01

We present the optical design of a Czerny-Turner imaging spectrometer for which astigmatism is corrected using off-the-shelf optics resulting in spectral resolution of 0.1 nm. The classic Czerny-Turner imaging spectrometer, consisting of a plane grating, two spherical mirrors, and a sensor with 10-μm pixels, was used as the benchmark. We comparatively assessed three configurations of the spectrometer that corrected astigmatism with divergent illumination of the grating, by adding a cylindrical lens, or by adding a cylindrical mirror. When configured with the added cylindrical lens, the imaging spectrometer with a point field of view (FOV) and a linear sensor achieved diffraction-limited performance over a broadband width of 400 nm centered at 800 nm, while the maximum allowable bandwidth was only 200 nm for the other two configurations. When configured with the added cylindrical mirror, the imaging spectrometer with a one-dimensional field of view (1D FOV) and an area sensor showed its superiority on imaging quality, spectral nonlinearity, as well as keystone over 100 nm bandwidth and 10 mm spatial extent along the entrance slit.

75 FR 37711 - Automatic Dependent Surveillance-Broadcast (ADS-B) Out Performance Requirements To Support Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... Performance Requirements To Support Air Traffic Control (ATC) Service; Correction AGENCY: Federal Aviation... performance standards for Automatic Dependent Surveillance--Broadcast (ADS-B) Out avionics on aircraft... entitled, ``Automatic Dependent Surveillance--Broadcast (ADS-B) Out Performance Requirements To Support Air...

78 FR 39633 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

...We propose to supersede three existing airworthiness directives (ADs) that apply to The Boeing Company Model 757-200, - 200PF, and -200CB series airplanes. The existing ADs currently require repetitive inspections and audible tap tests of the upper and lower skins of the trailing edge wedges on certain slats, and related investigative and corrective actions if necessary. Since we issued these ADs, we have received reports of slats disbonding on airplanes on which the terminating actions of the existing ADs were completed and also reports of slats disbonding on airplanes outside of the applicability of the existing ADs. This proposed AD would require a determination of the type of trailing edge wedges of the leading edge slats, repetitive inspections on certain trailing edge wedges for areas of skin-to-core disbonding, and corrective actions if necessary. This proposed AD would also provide an optional terminating action for the repetitive inspections. This AD would revise the applicability of the existing ADs to include additional airplanes. We are proposing this AD to prevent delamination of the trailing edge wedge of the leading edge slats, possible loss of pieces of the trailing edge wedge assembly during flight, reduction of the reduced maneuver and stall margins, and consequent reduced controllability of the airplane.

77 FR 59728 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... correct installation of certain bonding straps, and applicable corrective actions. This new AD adds... the potential of ignition sources inside fuel tanks in the event of a severe lightning strike, which... installation of certain bonding straps, and applicable corrective actions. That NPRM also proposed to add...

Author Correction: Geometric constraints during epithelial jamming

NASA Astrophysics Data System (ADS)

Atia, Lior; Bi, Dapeng; Sharma, Yasha; Mitchel, Jennifer A.; Gweon, Bomi; Koehler, Stephan A.; DeCamp, Stephen J.; Lan, Bo; Kim, Jae Hun; Hirsch, Rebecca; Pegoraro, Adrian F.; Lee, Kyu Ha; Starr, Jacqueline R.; Weitz, David A.; Martin, Adam C.; Park, Jin-Ah; Butler, James P.; Fredberg, Jeffrey J.

2018-06-01

In the first correction to this Article, the authors added James P. Butler and Jeffrey J. Fredburg as equally contributing authors. However, this was in error; the statement should have remained indicating that Lior Atia, Dapeng Bi and Yasha Sharma contributed equally. This has now been corrected.

78 FR 21045 - Adaptation of Regulations to Incorporate Swaps-Records of Transactions; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-09

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 1 RIN 3038-AD53 Adaptation of Regulations to Incorporate Swaps--Records of Transactions; Correction AGENCY: Commodity Futures Trading Commission. ACTION...), regarding Adaptation of Regulations to Incorporate Swaps--Records of Transactions. DATES: This correction to...

Leica ADS40 Sensor for Coastal Multispectral Imaging

NASA Technical Reports Server (NTRS)

Craig, John C.

2007-01-01

The Leica ADS40 Sensor as it is used for coastal multispectral imaging is presented. The contents include: 1) Project Area Overview; 2) Leica ADS40 Sensor; 3) Focal Plate Arrangements; 4) Trichroid Filter; 5) Gradient Correction; 6) Image Acquisition; 7) Remote Sensing and ADS40; 8) Band comparisons of Satellite and Airborne Sensors; 9) Impervious Surface Extraction; and 10) Impervious Surface Details.

76 FR 72863 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... discrepancies if necessary. This proposed AD was prompted by reports of stress corrosion cracking in the chord... segments made from 7075 aluminum. We are proposing this AD to detect and correct stress corrosion and/or... proposed AD. Discussion We have received numerous reports of stress corrosion cracking in the chord...

77 FR 37827 - Airworthiness Directives; The Cessna Aircraft Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

...) generator control unit (GCU). We are proposing this AD to prevent DC generator overvoltage events, which... proposed AD. Discussion We have received reports of direct current (DC) generator overvoltage events. The... generator and the left and right engine DC generators, and corrective actions if necessary. That AD also...

77 FR 58973 - Airworthiness Directives; Eurocopter France Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-25

... function correctly. We propose this AD to prevent an uncommanded landing gear retraction that would cause... electrical interferences on the solenoid valve power supply line have caused untimely retraction of the main... retraction. AD No. 2006-0152 classified portions of the ASB as mandatory. Proposed AD Requirements This...

75 FR 17889 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... reports of fuel leakage from the center tank. We are proposing this AD to detect and correct improperly... Condition (e) This AD results from reports of fuel leakage from the center tank. We are issuing this AD to...

Holographic helical superconductor with higher curvature corrections

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Subir; Paul, Chandrima

2018-01-01

We study SU(2) × U(1) gauge theory with Chern-Simons term, coupled to scalar field in adjoint, in Einstein-Gauss-Bonnet gravity. We explore phases of holographic superconductor in terms of the condensates and free energies in the background of AdS black hole and AdS soliton. In the case of black hole, we find with increasing strength of higher curvature terms, transition temperature decreases. For AdS soliton, the critical value of chemical potential increases as the higher curvature terms dominate.

Using eye-tracking to examine how embedding risk corrective statements improves cigarette risk beliefs: Implications for tobacco regulatory policy.

PubMed

Lochbuehler, Kirsten; Tang, Kathy Z; Souprountchouk, Valentina; Campetti, Dana; Cappella, Joseph N; Kozlowski, Lynn T; Strasser, Andrew A

2016-07-01

Tobacco companies have deliberately used explicit and implicit misleading information in marketing campaigns. The aim of the current study was to experimentally investigate whether the editing of explicit and implicit content of a print advertisement improves smokers' risk beliefs and smokers' knowledge of explicit and implicit information. Using a 2(explicit/implicit)×2(accurate/misleading) between-subject design, 203 smokers were randomly assigned to one of four advertisement conditions. The manipulation of graphic content was examined as an implicit factor to convey product harm. The inclusion of a text corrective in the body of the ad was defined as the manipulated explicit factor. Participants' eye movements and risk beliefs/recall were measured during and after ad exposure, respectively. Results indicate that exposure to a text corrective decreases false beliefs about the product (p<.01) and improves correct recall of information provided by the corrective (p<.05). Accurate graphic content did not alter the harmfulness of the product. Independent of condition, smokers who focused longer on the warning label made fewer false inferences about the product (p=.01) and were more likely to correctly recall the warning information (p<.01). Nonetheless, most smokers largely ignored the text warning. Embedding a corrective statement in the body of the ad is an effective strategy to convey health information to consumers, which can be mandated under the Tobacco Control Act. Eye-tracking results objectively demonstrate that text-only warnings are not viewed by smokers, thus minimizing their effectiveness for conveying risk information. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Using Eye-tracking to Examine How Embedding Risk Corrective Statements Improves Cigarette Risk Beliefs: Implications for Tobacco Regulatory Policy

PubMed Central

Lochbuehler, Kirsten; Tang, Kathy Z.; Souprountchouk, Valentina; Campetti, Dana; Cappella, Joseph N.; Kozlowski, Lynn T.; Strasser, Andrew A.

2016-01-01

Background Tobacco companies have deliberately used explicit and implicit misleading information in marketing campaigns. The aim of the current study was to experimentally investigate whether the editing of explicit and implicit content of a print advertisement improves smokers’ risk beliefs and smokers’ knowledge of explicit and implicit information. Methods Using a 2(explicit/implicit) x 2(accurate/misleading) between-subject design, 203 smokers were randomly assigned to one of four advertisement conditions. The manipulation of graphic content was examined as an implicit factor to convey product harm. The inclusion of a text corrective in the body of the ad was defined as the manipulated explicit factor. Participants’ eye movements and risk beliefs/recall were measured during and after ad exposure, respectively. Results Results indicate that exposure to a text corrective decreases false beliefs about the product (p < .01) and improves correct recall of information provided by the corrective (p < .05). Accurate graphic content did not alter the harmfulness of the product. Independent of condition, smokers who focused longer on the warning label made fewer false inferences about the product (p = .01) and were more likely to correctly recall the warning information (p < .01). Nonetheless, most smokers largely ignored the text warning. Conclusions Embedding a corrective statement in the body of the ad is an effective strategy to convey health information to consumers, which can be mandated under the Tobacco Control Act (2009). Eye-tracking results objectively demonstrate that text-only warnings are not viewed by smokers, thus minimizing their effectiveness for conveying risk information. PMID:27160034

78 FR 42724 - Airworthiness Directives; Beechcraft Corporation Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-17

... certain Beechcraft Corporation Models 1900, 1900C, and 1900D airplanes. AD 2011-27-51 currently requires... deformation to the weight and/or weight bracket with corrective action as necessary. Since we issued AD 2011..., January 18, 2012), for certain Hawker Beechcraft Corporation Models 1900, 1900C, and 1900D airplanes. AD...

77 FR 72200 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... correctly on the engine fuel feed manifold couplings. This AD also requires inspecting the assembly of the engine fuel feed manifold rigid and full flexible couplings. This AD was prompted by reports of fuel leaks due to improperly assembled engine fuel feed manifold couplings. We are issuing this AD to detect...

78 FR 66859 - Airworthiness Directives; the Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-07

... airplanes. This proposed AD was prompted by reports of bearing damage at certain trailing edge (TE) flap... certain trailing edge (TE) flap support rib assemblies. We are issuing this AD to detect and correct...

Estimated Effects of Different Alcohol Taxation and Price Policies on Health Inequalities: A Mathematical Modelling Study

PubMed Central

Meier, Petra S.; Holmes, John; Angus, Colin; Ally, Abdallah K.; Meng, Yang; Brennan, Alan

2016-01-01

Introduction While evidence that alcohol pricing policies reduce alcohol-related health harm is robust, and alcohol taxation increases are a WHO “best buy” intervention, there is a lack of research comparing the scale and distribution across society of health impacts arising from alternative tax and price policy options. The aim of this study is to test whether four common alcohol taxation and pricing strategies differ in their impact on health inequalities. Methods and Findings An econometric epidemiological model was built with England 2014/2015 as the setting. Four pricing strategies implemented on top of the current tax were equalised to give the same 4.3% population-wide reduction in total alcohol-related mortality: current tax increase, a 13.4% all-product duty increase under the current UK system; a value-based tax, a 4.0% ad valorem tax based on product price; a strength-based tax, a volumetric tax of £0.22 per UK alcohol unit (= 8 g of ethanol); and minimum unit pricing, a minimum price threshold of £0.50 per unit, below which alcohol cannot be sold. Model inputs were calculated by combining data from representative household surveys on alcohol purchasing and consumption, administrative and healthcare data on 43 alcohol-attributable diseases, and published price elasticities and relative risk functions. Outcomes were annual per capita consumption, consumer spending, and alcohol-related deaths. Uncertainty was assessed via partial probabilistic sensitivity analysis (PSA) and scenario analysis. The pricing strategies differ as to how effects are distributed across the population, and, from a public health perspective, heavy drinkers in routine/manual occupations are a key group as they are at greatest risk of health harm from their drinking. Strength-based taxation and minimum unit pricing would have greater effects on mortality among drinkers in routine/manual occupations (particularly for heavy drinkers, where the estimated policy effects on mortality rates are as follows: current tax increase, −3.2%; value-based tax, −2.9%; strength-based tax, −6.1%; minimum unit pricing, −7.8%) and lesser impacts among drinkers in professional/managerial occupations (for heavy drinkers: current tax increase, −1.3%; value-based tax, −1.4%; strength-based tax, +0.2%; minimum unit pricing, +0.8%). Results from the PSA give slightly greater mean effects for both the routine/manual (current tax increase, −3.6% [95% uncertainty interval (UI) −6.1%, −0.6%]; value-based tax, −3.3% [UI −5.1%, −1.7%]; strength-based tax, −7.5% [UI −13.7%, −3.9%]; minimum unit pricing, −10.3% [UI −10.3%, −7.0%]) and professional/managerial occupation groups (current tax increase, −1.8% [UI −4.7%, +1.6%]; value-based tax, −1.9% [UI −3.6%, +0.4%]; strength-based tax, −0.8% [UI −6.9%, +4.0%]; minimum unit pricing, −0.7% [UI −5.6%, +3.6%]). Impacts of price changes on moderate drinkers were small regardless of income or socioeconomic group. Analysis of uncertainty shows that the relative effectiveness of the four policies is fairly stable, although uncertainty in the absolute scale of effects exists. Volumetric taxation and minimum unit pricing consistently outperform increasing the current tax or adding an ad valorem tax in terms of reducing mortality among the heaviest drinkers and reducing alcohol-related health inequalities (e.g., in the routine/manual occupation group, volumetric taxation reduces deaths more than increasing the current tax in 26 out of 30 probabilistic runs, minimum unit pricing reduces deaths more than volumetric tax in 21 out of 30 runs, and minimum unit pricing reduces deaths more than increasing the current tax in 30 out of 30 runs). Study limitations include reducing model complexity by not considering a largely ineffective ban on below-tax alcohol sales, special duty rates covering only small shares of the market, and the impact of tax fraud or retailer non-compliance with minimum unit prices. Conclusions Our model estimates that, compared to tax increases under the current system or introducing taxation based on product value, alcohol-content-based taxation or minimum unit pricing would lead to larger reductions in health inequalities across income groups. We also estimate that alcohol-content-based taxation and minimum unit pricing would have the largest impact on harmful drinking, with minimal effects on those drinking in moderation. PMID:26905063

Integrability in AdS/CFT correspondence: quasi-classical analysis

NASA Astrophysics Data System (ADS)

Gromov, Nikolay

2009-06-01

In this review, we consider a quasi-classical method applicable to integrable field theories which is based on a classical integrable structure—the algebraic curve. We apply it to the Green-Schwarz superstring on the AdS5 × S5 space. We show that the proposed method reproduces perfectly the earlier results obtained by expanding the string action for some simple classical solutions. The construction is explicitly covariant and is not based on a particular parameterization of the fields and as a result is free from ambiguities. On the other hand, the finite size corrections in some particularly important scaling limit are studied in this paper for a system of Bethe equations. For the general superalgebra \\su(N|K) , the result for the 1/L corrections is obtained. We find an integral equation which describes these corrections in a closed form. As an application, we consider the conjectured Beisert-Staudacher (BS) equations with the Hernandez-Lopez dressing factor where the finite size corrections should reproduce quasi-classical results around a general classical solution. Indeed, we show that our integral equation can be interpreted as a sum of all physical fluctuations and thus prove the complete one-loop consistency of the BS equations. We demonstrate that any local conserved charge (including the AdS energy) computed from the BS equations is indeed given at one loop by the sum of the charges of fluctuations with an exponential precision for large S5 angular momentum of the string. As an independent result, the BS equations in an \\su(2) sub-sector were derived from Zamolodchikovs's S-matrix. The paper is based on the author's PhD thesis.

Abnormal functional connectivity of the posterior cingulate cortex is associated with depressive symptoms in patients with Alzheimer’s disease

PubMed Central

Zhang, Jiangtao; Guo, Zhongwei; Liu, Xiaozheng; Jia, Xize; Li, Jiapeng; Li, Yaoyao; Lv, Danmei; Chen, Wei

2017-01-01

Background Depressive symptoms are significant and very common psychiatric complications in patients with Alzheimer’s disease (AD), which can aggravate the decline in social function. However, changes in the functional connectivity (FC) of the brain in AD patients with depressive symptoms (D-AD) remain unclear. Objective To investigate whether any differences exist in the FC of the posterior cingulate cortex (PCC) between D-AD patients and non-depressed AD patients (nD-AD). Materials and methods We recruited 15 D-AD patients and 17 age-, sex-, educational level-, and Mini-Mental State Examination (MMSE)-matched nD-AD patients to undergo tests using the Neuropsychiatric Inventory, Hamilton Depression Rating Scale, and 3.0T resting-state functional magnetic resonance imaging. Bilateral PCC were selected as the regions of interest and between-group differences in the PCC FC network were assessed using Student’s t-test. Results Compared with the nD-AD group, D-AD patients showed increased PCC FC in the right amygdala, right parahippocampus, right superior temporal pole, right middle temporal lobe, right middle temporal pole, and right hippocampus (AlphaSim correction; P<0.05). In the nD-AD group, MMSE scores were positively correlated with PCC FC in the right superior temporal pole and right hippocampus (false discovery rate corrected; P<0.05). Conclusion Differences were detected in PCC FC between nD-AD and D-AD patients, which may be related to depressive symptoms. Our study provides a significant enhancement to our understanding of the functional mechanisms underlying D-AD. PMID:29066900

Thermodynamic variables of first-order entropy corrected Lovelock-AdS black holes: P{-}V criticality analysis

NASA Astrophysics Data System (ADS)

Haldar, Amritendu; Biswas, Ritabrata

2018-06-01

We investigate the effect of thermal fluctuations on the thermodynamics of a Lovelock-AdS black hole. Taking the first order logarithmic correction term in entropy we analyze the thermodynamic potentials like Helmholtz free energy, enthalpy and Gibbs free energy. We find that all the thermodynamic potentials are decreasing functions of correction coefficient α . We also examined this correction coefficient must be positive by analysing P{-}V diagram. Further we study the P{-}V criticality and stability and find that presence of logarithmic correction in it is necessary to have critical points and stable phases. When P{-}V criticality appears, we calculate the critical volume V_c, critical pressure P_c and critical temperature T_c using different equations and show that there is no critical point for this black hole without thermal fluctuations. We also study the geometrothermodynamics of this kind of black holes. The Ricci scalar of the Ruppeiner metric is graphically analysed.

Ka-Band ARM Zenith Radar Corrections Value-Added Product

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Karen; Toto, Tami; Giangrande, Scott

The KAZRCOR Value -added Product (VAP) performs several corrections to the ingested KAZR moments and also creates a significant detection mask for each radar mode. The VAP computes gaseous attenuation as a function of time and radial distance from the radar antenna, based on ambient meteorological observations, and corrects observed reflectivities for that effect. KAZRCOR also dealiases mean Doppler velocities to correct velocities whose magnitudes exceed the radar’s Nyquist velocity. Input KAZR data fields are passed through into the KAZRCOR output files, in their native time and range coordinates. Complementary corrected reflectivity and velocity fields are provided, along with amore » mask of significant detections and a number of data quality flags. This report covers the KAZRCOR VAP as applied to the original KAZR radars and the upgraded KAZR2 radars. Currently there are two separate code bases for the different radar versions, but once KAZR and KAZR2 data formats are harmonized, only a single code base will be required.« less

Effect of curvature squared corrections to gravitational action on viscosity-to-entropy ratio of the dual gauge theory

NASA Astrophysics Data System (ADS)

Petrov, Pavel

In this thesis we study the properties of strongly-coupled large-N conformal field theories (CFT's) using AdS/CFT correspondence. Chapter 1 serves as an introduction. In Chapter 2 we study the shear viscosity of strongly-coupled large-N conformal field theories. We find that it is affected by R2 corrections to the AdS action and present an example of 4D theory in which the the conjectured universal lower bound on viscosity-to-entropy ratio η/s > 1/4π is violated by 1/N corrections. This fact proves that there is no universal lower bound of 1/4π on viscosity-to-entropy ratio and may be relevant for the studies of QCD quark-gluon plasma for which this ratio is experimentally found to be close to 1/4π. In Chapter 3 we study the formation of the electron star in 4D AdS space. We show that in a gravity theory with charged fermions a layer of charged fermion fluid may form at a finite distance from the charged black hole. We show that these “electron stars” are candidate gravity duals for strongly interacting fermion systems at finite density and finite temperature. Entropy density for such systems scales as s ˜ T2/z at low temperatures as expected from IR criticality of electron stars solutions.

Source Memory for Self and Other in Patients With Mild Cognitive Impairment due to Alzheimer’s Disease

PubMed Central

Deason, Rebecca G.; Budson, Andrew E.; Gutchess, Angela H.

2016-01-01

Objectives. The present study examined the role of enactment in source memory in a cognitively impaired population. As seen in healthy older adults, it was predicted that source memory in people with mild cognitive impairment due to Alzheimer’s disease (MCI-AD) would benefit from the self-reference aspect of enactment. Method. Seventeen participants with MCI-AD and 18 controls worked in small groups to pack a picnic basket and suitcase and were later tested for their source memory for each item. Results. For item memory, self-referencing improved corrected recognition scores for both MCI-AD and control participants. The MCI-AD group did not demonstrate the same benefit as controls in correct source memory for self-related items. However, those with MCI-AD were relatively less likely to misattribute new items to the self and more likely to misattribute new items to others when committing errors, compared with controls. Discussion. The enactment effect and self-referencing did not enhance accurate source memory more than other referencing for patients with MCI-AD. However, people with MCI-AD benefited in item memory and source memory, being less likely to falsely claim new items as their own, indicating some self-reference benefit occurs for people with MCI-AD. PMID:24904049

Source Memory for Self and Other in Patients With Mild Cognitive Impairment due to Alzheimer's Disease.

PubMed

Rosa, Nicole M; Deason, Rebecca G; Budson, Andrew E; Gutchess, Angela H

2016-01-01

The present study examined the role of enactment in source memory in a cognitively impaired population. As seen in healthy older adults, it was predicted that source memory in people with mild cognitive impairment due to Alzheimer's disease (MCI-AD) would benefit from the self-reference aspect of enactment. Seventeen participants with MCI-AD and 18 controls worked in small groups to pack a picnic basket and suitcase and were later tested for their source memory for each item. For item memory, self-referencing improved corrected recognition scores for both MCI-AD and control participants. The MCI-AD group did not demonstrate the same benefit as controls in correct source memory for self-related items. However, those with MCI-AD were relatively less likely to misattribute new items to the self and more likely to misattribute new items to others when committing errors, compared with controls. The enactment effect and self-referencing did not enhance accurate source memory more than other referencing for patients with MCI-AD. However, people with MCI-AD benefited in item memory and source memory, being less likely to falsely claim new items as their own, indicating some self-reference benefit occurs for people with MCI-AD. Published by Oxford University Press on behalf of the Gerontological Society of America 2014.

The traveling salesman problem as a new screening test in early Alzheimer's disease: an exploratory study. Visual problem-solving in AD.

PubMed

De Vreese, Luc Pieter; Pradelli, Samantha; Massini, Giulia; Buscema, Massimo; Savarè, Rita; Grossi, Enzo

2005-12-01

In the clinical setting, brief general mental status tests tend to detect early-stage Alzheimer's disease (AD) less well than more specific cognitive tests. Some preliminary information was collected on the diagnostic accuracy of the Traveling Salesman Problem (TSP) compared with the Mini-Mental State Examination (MMSE) in recognizing early AD from normal aging. Fifteen AD outpatients (mean +/- SD MMSE: 24.45 +/- 2.61) and 30 age- and education-matched controls were submitted in a single blind protocol to a paper-and-pencil visually-presented version of the TSP, containing a random array of 30 points (TSP30). The task consisted of drawing the shortest continuous path, passing through each point once and only once, and returning to the starting point. Path lengths for subjects' solutions were computed and compared with the optimal solution given by a specific evolutionary algorithm called GenD. TP30 discriminated significantly better between AD subjects and controls (ROC curve AUC = 0.976; 95% CI 0.94-1.01) compared with the MMSE corrected for age and education (ROC curve AUC = 0.877; 95% CI 0.74-1.005). A path length of 478.2354, taken as "cut-off point", classified correctly subjects with a sensitivity of 93.3% and a specificity of 99.3%, whereas a score corrected for age and education of 25.85 on the MMSE had a sensitivity of 73.3% and a specificity of 96.7%. The TSP seems to be particularly sensitive to early AD and independent of patient's age and educational level. The high diagnostic ability, simplicity, and independence of age and education make the TSP promising as a screening test for early AD.

Higher Curvature Gravity from Entanglement in Conformal Field Theories.

PubMed

Haehl, Felix M; Hijano, Eliot; Parrikar, Onkar; Rabideau, Charles

2018-05-18

By generalizing different recent works to the context of higher curvature gravity, we provide a unifying framework for three related results: (i) If an asymptotically anti-de Sitter (AdS) spacetime computes the entanglement entropies of ball-shaped regions in a conformal field theory using a generalized Ryu-Takayanagi formula up to second order in state deformations around the vacuum, then the spacetime satisfies the correct gravitational equations of motion up to second order around the AdS background. (ii) The holographic dual of entanglement entropy in higher curvature theories of gravity is given by the Wald entropy plus a particular correction term involving extrinsic curvatures. (iii) Conformal field theory relative entropy is dual to gravitational canonical energy (also in higher curvature theories of gravity). Especially for the second point, our novel derivation of this previously known statement does not involve the Euclidean replica trick.

Higher Curvature Gravity from Entanglement in Conformal Field Theories

NASA Astrophysics Data System (ADS)

Haehl, Felix M.; Hijano, Eliot; Parrikar, Onkar; Rabideau, Charles

2018-05-01

By generalizing different recent works to the context of higher curvature gravity, we provide a unifying framework for three related results: (i) If an asymptotically anti-de Sitter (AdS) spacetime computes the entanglement entropies of ball-shaped regions in a conformal field theory using a generalized Ryu-Takayanagi formula up to second order in state deformations around the vacuum, then the spacetime satisfies the correct gravitational equations of motion up to second order around the AdS background. (ii) The holographic dual of entanglement entropy in higher curvature theories of gravity is given by the Wald entropy plus a particular correction term involving extrinsic curvatures. (iii) Conformal field theory relative entropy is dual to gravitational canonical energy (also in higher curvature theories of gravity). Especially for the second point, our novel derivation of this previously known statement does not involve the Euclidean replica trick.

Thermodynamic instability of topological black holes in Gauss-Bonnet gravity with a generalized electrodynamics

NASA Astrophysics Data System (ADS)

Hendi, S. H.; Panahiyan, S.

2014-12-01

Motivated by the string corrections on the gravity and electrodynamics sides, we consider a quadratic Maxwell invariant term as a correction of the Maxwell Lagrangian to obtain exact solutions of higher dimensional topological black holes in Gauss-Bonnet gravity. We first investigate the asymptotically flat solutions and obtain conserved and thermodynamic quantities which satisfy the first law of thermodynamics. We also analyze thermodynamic stability of the solutions by calculating the heat capacity and the Hessian matrix. Then, we focus on horizon-flat solutions with an anti-de Sitter (AdS) asymptote and produce a rotating spacetime with a suitable transformation. In addition, we calculate the conserved and thermodynamic quantities for asymptotically AdS black branes which satisfy the first law of thermodynamics. Finally, we perform thermodynamic instability criterion to investigate the effects of nonlinear electrodynamics in canonical and grand canonical ensembles.

Theoretical calculation of enthalpy of formation of multiconformational molecules: 1,2-ethanediol, propanediols, and glycerol

NASA Astrophysics Data System (ADS)

Dorofeeva, Olga V.; Suchkova, Taisiya A.

2018-04-01

The gas-phase enthalpies of formation of four molecules with high flexibility, which leads to the existence of a large number of low-energy conformers, were calculated with the G4 method to see whether the lowest energy conformer is sufficient to achieve high accuracy in the computed values. The calculated values were in good agreement with the experiment, whereas adding the correction for conformer distribution makes the agreement worse. The reason for this effect is a large anharmonicity of low-frequency torsional motions, which is ignored in the calculation of ZPVE and thermal enthalpy. It was shown that the approximate correction for anharmonicity estimated using a free rotor model is of very similar magnitude compared with the conformer correction but has the opposite sign, and thus almost fully compensates for it. Therefore, the common practice of adding only the conformer correction is not without problems.

77 FR 22686 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

...-500 series airplanes. This proposed AD was prompted by reports of chem-mill step cracking on the aft...-mill steps, and repair if necessary. We are proposing this AD to detect and correct cracking on the aft... proposed AD. Discussion More than 300 incidents of skin chem-mill cracks on 26 airplanes have been reported...

76 FR 50881 - Airworthiness Directives; M7 Aerospace LP Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

... interconnect primary control cables, and checking and setting of flight control cable tension. This AD was prompted by a report of a failure of a rudder control cable. We are issuing this AD to correct the unsafe... paragraphs (g)(2) or (h)(1) of this AD, check (set) flight control cable tension. (i) Alternative Methods of...

76 FR 6533 - Airworthiness Directives; Hawker Beechcraft Corporation (Type Certificate Previously Held by...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-07

... (FAA), DOT. ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for the products listed above. This AD requires a detailed inspection for proper sealant of the left and right... sealant on the left and right pylon firewall structures. We are issuing this AD to detect and correct...

Defense Logistics Agency Disposition Services Afghanistan Disposal Process Needed Improvement

DTIC Science & Technology

2013-11-08

audit, and management was proactive in correcting the deficiencies we identified. DLA DS eliminated backlogs, identified and corrected system ...problems, provided additional system training, corrected coding errors, added personnel to key positions, addressed scale issues, submitted debit...Service Automated Information System to the Reutilization Business Integration2 (RBI) solution. The implementation of RBI in Afghanistan occurred in

Proteomics-Derived Cerebrospinal Fluid Markers of Autopsy-Confirmed Alzheimer’s Disease

PubMed Central

Roher, Alex E.; Maarouf, Chera L.; Sue, Lucia I.; Hu, Yiran; Wilson, Jeffrey; Beach, Thomas G.

2010-01-01

The diagnostic performance of several candidate cerebrospinal fluid (CSF) protein biomarkers of neuropathologically-confirmed Alzheimer’s disease (AD), non-demented (ND) elderly controls and non-AD dementias (NADD) was assessed. Candidate markers were selected on the basis of initial 2-dimensional gel electrophoresis studies or by literature review. Markers selected by the former method included apolipoprotein A-1 (ApoA1), hemopexin (HPX), transthyretin (TTR) and pigment epithelium-derived factor (PEDF) while markers identified from the literature included Aβ1–40, Aβ1–42, total tau, phosphorylated tau, α-1 acid glycoprotein (A1GP), haptoglobin, zinc α-2 glycoprotein (Z2GP) and apolipoprotein E (ApoE). Ventricular CSF concentrations of the markers were measured by ELISA. The concentrations of Aβ1–42, ApoA1, A1GP, ApoE, HPX and Z2GP differed significantly among AD, ND and NADD subjects. Logistic regression analysis for the diagnostic discrimination of AD from ND found that Aβ1–42, ApoA1 and HPX each had significant and independent associations with diagnosis. The CSF concentrations of these three markers distinguished AD from ND subjects with 84% sensitivity and 72% specificity, with 78% of subjects correctly classified. By comparison, using Aβ1–42 alone gave 79% sensitivity and 61% specificity, with 68% of subjects correctly classified. For the diagnostic discrimination of AD from NADD, only the concentration of Aβ1–42 was significantly related to diagnosis, with a sensitivity of 58%, specificity of 86% and 86% correctly classified. The results indicate that for the discrimination of AD from ND control subjects, measurement of a set of markers including Aβ1–42, ApoA1 and HPX improved diagnostic performance over that obtained by measurement of Aβ1–42 alone. For the discrimination of AD from NADD subjects, measurement of Aβ1–42 alone was superior. PMID:19863188

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

PubMed

Hinrich, Anthony J; Jodelka, Francine M; Chang, Jennifer L; Brutman, Daniella; Bruno, Angela M; Briggs, Clark A; James, Bryan D; Stutzmann, Grace E; Bennett, David A; Miller, Steven A; Rigo, Frank; Marr, Robert A; Hastings, Michelle L

2016-04-01

Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long-term potentiation, learning, and memory. Given its role in cognition and its association with the Alzheimer's disease (AD) risk gene, apoE, ApoER2 has been proposed to be involved in AD, though a role for the receptor in the disease is not clear. ApoER2 signaling requires amino acids encoded by alternatively spliced exon 19. Here, we report that the balance of ApoER2 exon 19 splicing is deregulated in postmortem brain tissue from AD patients and in a transgenic mouse model of AD To test the role of deregulated ApoER2 splicing in AD, we designed an antisense oligonucleotide (ASO) that increases exon 19 splicing. Treatment of AD mice with a single dose of ASO corrected ApoER2 splicing for up to 6 months and improved synaptic function and learning and memory. These results reveal an association between ApoER2 isoform expression and AD, and provide preclinical evidence for the utility of ASOs as a therapeutic approach to mitigate Alzheimer's disease symptoms by improving ApoER2 exon 19 splicing. © 2016 The Authors. Published under the terms of the CC BY 4.0 license.

Improving the patient-clinician and parent-clinician partnership in atopic dermatitis management.

PubMed

Mancini, Anthony J; Paller, Amy S; Simpson, Eric L; Ellis, Charles N; Eichenfield, Lawrence F

2012-09-01

Long-term adherence to carefully developed, individualized strategies is necessary for the optimum treatment outcomes in patients with atopic dermatitis (AD). However, the parents of children with AD frequently lack sufficient information about the disease and its treatment, hold incorrect and sometimes harmful beliefs about these issues, and too often do not follow through consistently with the treatment plan. The health care provider is the primary source of such education, so an effective provider relationship is fundamental to adherence. In addition to the provision of correct information and the correction of misinformation, clinicians must be aware of and must address barriers to adherence with AD therapy, especially parent anxiety about the safety of topical medications (corticosteroids and topical calcineurin inhibitors). Copyright © 2012 Elsevier Inc. All rights reserved.

A design of PAL with astigmatism

NASA Astrophysics Data System (ADS)

Wei, Yefei; Xiang, Huazhong; Zhu, Tianfeng; Chen, Jiabi

2015-08-01

Progressive addition lens (PAL) is designed for those who suffer from myopia and presbyopia to have a clear vision from a far distance to a nearby distance. Additionally there are many people that also suffer from astigmatism and need to be corrected. The cylinder power can't be simply added to the diopter of the PAL directly, because the diopter of the PAL needs to be changed smoothly. A methods has been proposed in this article to solve the problem, the freeform surface height of a PAL without astigmatism and the cylindrical lens surface height for the correction of astigmatism are calculated separately. The both two surface heights were added together, then the final surface is produced and shown with the both properties of PALs and cylindrical lenses used to correct the astigmatism.

78 FR 6272 - Rules Relating to Additional Medicare Tax; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... Rules Relating to Additional Medicare Tax; Correction AGENCY: Internal Revenue Service (IRS), Treasury... regulations are relating to Additional Hospital Insurance Tax on income above threshold amounts (``Additional Medicare Tax''), as added by the Affordable Care Act. Specifically, these proposed regulations provide...

Holographic Rényi entropy in AdS3/LCFT2 correspondence

NASA Astrophysics Data System (ADS)

Chen, Bin; Song, Feng-yan; Zhang, Jia-ju

2014-03-01

The recent study in AdS3/CFT2 correspondence shows that the tree level contribution and 1-loop correction of holographic Rényi entanglement entropy (HRE) exactly match the direct CFT computation in the large central charge limit. This allows the Rényi entanglement entropy to be a new window to study the AdS/CFT correspondence. In this paper we generalize the study of Rényi entanglement entropy in pure AdS3 gravity to the massive gravity theories at the critical points. For the cosmological topological massive gravity (CTMG), the dual conformal field theory (CFT) could be a chiral conformal field theory or a logarithmic conformal field theory (LCFT), depending on the asymptotic boundary conditions imposed. In both cases, by studying the short interval expansion of the Rényi entanglement entropy of two disjoint intervals with small cross ratio x, we find that the classical and 1-loop HRE are in exact match with the CFT results, up to order x 6. To this order, the difference between the massless graviton and logarithmic mode can be seen clearly. Moreover, for the cosmological new massive gravity (CNMG) at critical point, which could be dual to a logarithmic CFT as well, we find the similar agreement in the CNMG/LCFT correspondence. Furthermore we read the 2-loop correction of graviton and logarithmic mode to HRE from CFT computation. It has distinct feature from the one in pure AdS3 gravity.

Mechanisms underlying the production of false memories for famous people's names in aging and Alzheimer's disease.

PubMed

Plancher, Gaën; Guyard, Anne; Nicolas, Serge; Piolino, Pascale

2009-10-01

It is well known that the occurrence of false memories increases with aging, but the results remain inconsistent concerning Alzheimer's disease (AD). Moreover, the mechanisms underlying the production of false memories are still unclear. Using an experimental episodic memory test with material based on the names of famous people in a procedure derived from the DRM paradigm [Roediger, H. L., III, & McDermott, K. B. (1995). Creating false memories: Remembering words not presented in lists. Journal of Experimental Psychology: Learning, Memory & Cognition, 21, 803-814], we examined correct and false recall and recognition in 30 young adults, 40 healthy older adults, and 30 patients with AD. Moreover, we evaluated the relationships between false memory performance, correct episodic memory performance, and a set of neuropsychological assessments evaluating the semantic memory and executive functions. The results clearly indicated that correct recall and recognition performance decreased with the subjects' age, but it decreased even more with AD. In addition, semantically related false recalls and false recognitions increased with age but not with dementia. On the contrary, non-semantically related false recalls and false recognitions increased with AD. Finally, the regression analyses showed that executive functions mediated related false memories and episodic memory mediated related and unrelated false memories in aging. Moreover, executive functions predicted related and unrelated false memories in AD, and episodic and semantic memory predicted semantically related and unrelated false memories in AD. In conclusion, the results obtained are consistent with the current constructive models of memory suggesting that false memory creation depends on different cognitive functions and, consequently, that the impairments of these functions influence the production of false memories.

78 FR 65171 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... airplane undergoing a passenger- to-freighter conversion. This AD requires doing a general visual... service information identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services... proposed to require doing a general visual inspection of the station 1920 splice clip for correct fastener...

77 FR 57995 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-0997; Directorate Identifier 2011-NM-043-AD; Amendment 39-16963; AD 2012-04-07] RIN 2120-AA64... of the issue of Monday, March 5, 2012 make the following correction: [[Page 57996

77 FR 71723 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... directive (AD) that applies to certain The Boeing Company Model 737-200, -200C, - 300, and -400 series... related investigative and corrective actions, and revise certain inspection types. This proposed AD would...

76 FR 13546 - Airworthiness Directives; The Boeing Company Model MD-90-30 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

...We propose to adopt a new airworthiness directive (AD) for the products listed above. This proposed AD would require a detailed inspection to detect distress and existing repairs to the leading edge structure of the vertical stabilizer at the splice at Station Zfs=52.267; repetitive inspections for cracking in the front spar cap forward flanges of the vertical stabilizer, and either the aft flanges or side skins; repetitive inspections for loose and missing fasteners; and related investigative and corrective actions if necessary. This proposed AD was prompted by reports of cracked vertical stabilizer skin, a severed front spar cap, elongated fastener holes at the leading edge of the vertical stabilizer, and a cracked front spar web and front spar cap bolt holes in the vertical stabilizer. We are proposing this AD to detect and correct such cracking damage, which could result in the structure being unable to support limit load, and could lead to the loss of the vertical stabilizer.

76 FR 41651 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

...We are adopting a new airworthiness directive (AD) for the products listed above. This AD requires a detailed inspection to detect distress and existing repairs to the leading edge structure of the vertical stabilizer at the splice at Station Zfs = 52.267; repetitive inspections for cracking in the front spar cap forward flanges of the vertical stabilizer, and either the aft flanges or side skins; repetitive inspections for loose and missing fasteners; and related investigative and corrective actions if necessary. This AD was prompted by reports of cracked vertical stabilizer skin, a severed front spar cap, elongated fastener holes at the leading edge of the vertical stabilizer, and a cracked front spar web and front spar cap bolt holes in the vertical stabilizer. We are issuing this AD to detect and correct such cracking damage, which could result in the structure being unable to support limit load, and could lead to the loss of the vertical stabilizer.

76 FR 35342 - Airworthiness Directives; The Boeing Company Model MD-90-30 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

...We are adopting a new airworthiness directive (AD) for the products listed above. This AD requires a detailed inspection to detect distress and existing repairs to the leading edge structure of the vertical stabilizer at the splice at Station Zfs=52.267; repetitive inspections for cracking in the front spar cap forward flanges of the vertical stabilizer, and either the aft flanges or side skins; repetitive inspections for loose and missing fasteners; and related investigative and corrective actions if necessary. This AD was prompted by reports of cracked vertical stabilizer skin, a severed front spar cap, elongated fastener holes at the leading edge of the vertical stabilizer, and cracked front spar web and front spar cap bolt holes in the vertical stabilizer. We are issuing this AD to detect and correct such cracking damage, which could result in the structure being unable to support limit load, and could lead to the loss of the vertical stabilizer.

78 FR 37497 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-21

... and corrective actions if necessary. That AD resulted from fuel system reviews conducted by the... the fuel tanks are installed, and related investigative and corrective actions if necessary. Since the... CONTACT: Rebel Nichols, Aerospace Engineer, Propulsion Branch, ANM-140S, FAA, Seattle Aircraft...

14 CFR 29.1043 - Cooling tests.

Code of Federal Regulations, 2012 CFR

2012-01-01

... be of the minimum grade approved for the engines, and the mixture settings must be those used in... factor (except cylinder barrels). Unless a more rational correction applies, temperatures of engine..., must be corrected by adding to them the difference between the maximum ambient atmospheric temperature...

14 CFR 29.1043 - Cooling tests.

Code of Federal Regulations, 2011 CFR

2011-01-01

... be of the minimum grade approved for the engines, and the mixture settings must be those used in... factor (except cylinder barrels). Unless a more rational correction applies, temperatures of engine..., must be corrected by adding to them the difference between the maximum ambient atmospheric temperature...

78 FR 63903 - Airworthiness Directives; the Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM... corrective actions if necessary. This proposed AD also specifies an optional action of doing an inspection for corrosion damage of the bonding brackets, and corrective actions if necessary, which would...

77 FR 2928 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... pressure hose and electrical wiring of the green electrical motor pump (EMP). This proposed AD would... for correct condition and installation of hydraulic pressure hoses, electrical conduits, feeder cables... detect and correct chafing of hydraulic pressure hoses and electrical wiring of the green EMPs, which in...

75 FR 71526 - Corporate Credit Unions, Technical Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 704 RIN 3133-AD58 Corporate Credit Unions... request for comments. SUMMARY: NCUA is issuing technical corrections to its corporate credit union rule... for submitting comments. NCUA Web site: http://www.ncua.gov/Resources/RegulationsOpinionsLaws/Proposed...

Effect of astigmatism on visual acuity in eyes with a diffractive multifocal intraocular lens.

PubMed

Hayashi, Ken; Manabe, Shin-Ichi; Yoshida, Motoaki; Hayashi, Hideyuki

2010-08-01

To examine the effect of astigmatism on visual acuity at various distances in eyes with a diffractive multifocal intraocular lens (IOL). Hayashi Eye Hospital, Fukuoka, Japan. In this study, eyes had implantation of a diffractive multifocal IOL with a +3.00 diopter (D) addition (add) (AcrySof ReSTOR SN6AD1), a diffractive multifocal IOL with a +4.00 D add (AcrySof ReSTOR SN6AD3), or a monofocal IOL (AcrySof SN60WF). Astigmatism was simulated by adding cylindrical lenses of various diopters (0.00, 0.50, 1.00, 1.50, 2.00), after which distance-corrected acuity was measured at various distances. At most distances, the mean visual acuity in the multifocal IOL groups decreased in proportion to the added astigmatism. With astigmatism of 0.00 D and 0.50 D, distance-corrected near visual acuity (DCNVA) in the +4.00 D group and distance-corrected intermediate visual acuity (DCIVA) and DCNVA in the +3.00 D group were significantly better than in the monofocal group; the corrected distance visual acuity (CDVA) was similar. The DCNVA with astigmatism of 1.00 D was better in 2 multifocal groups; however, with astigmatism of 1.50 D and 2.00 D, the CDVA and DCIVA at 0.5m in the multifocal groups were significantly worse than in the monofocal group, although the DCNVA was similar. With astigmatism of 1.00 D or greater, the mean CDVA and DCNVA in the multifocal groups reached useful levels (20/40). The presence of astigmatism in eyes with a diffractive multifocal IOL compromised all distance visual acuities, suggesting the need to correct astigmatism of greater than 1.00 D. No author has a financial or proprietary interest in any material or method mentioned. Copyright 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Limited Associations of Dopamine System Genes With Alcohol Dependence and Related Traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)

PubMed Central

Hack, Laura M.; Kalsi, Gursharan; Aliev, Fazil; Kuo, Po-Hsiu; Prescott, Carol A.; Patterson, Diana G.; Walsh, Dermot; Dick, Danielle M.; Riley, Brien P.; Kendler, Kenneth S.

2012-01-01

Background Over 50 years of evidence from research has established that the central dopaminergic reward pathway is likely involved in alcohol dependence (AD). Additional evidence supports a role for dopamine (DA) in other disinhibitory psychopathology, which is often comorbid with AD. Family and twin studies demonstrate that a common genetic component accounts for most of the genetic variance in these traits. Thus, DA-related genes represent putative candidates for the genetic risk that underlies not only AD but also behavioral disinhibition. Many linkage and association studies have examined these relationships with inconsistent results, possibly because of low power, poor marker coverage, and/or an inappropriate correction for multiple testing. Methods We conducted an association study on the products encoded by 10 DA-related genes (DRD1-D5, SLC18A2, SLC6A3, DDC, TH, COMT) using a large, ethnically homogeneous sample with severe AD (n = 545) and screened controls (n = 509). We collected genotypes from linkage disequilibrium (LD)-tagging single nucleotide polymorphisms (SNPs) and employed a gene-based method of correction. We tested for association with AD diagnosis in cases and controls and with a variety of alcohol-related traits (including age-at-onset, initial sensitivity, tolerance, maximum daily drinks, and a withdrawal factor score), disinhibitory symptoms, and a disinhibitory factor score in cases only. A total of 135 SNPs were genotyped using the Illumina GoldenGate and Taqman Assays-on-Demand protocols. Results Of the 101 SNPs entered into standard analysis, 6 independent SNPs from 5 DA genes were associated with AD or a quantitative alcohol-related trait. Two SNPs across 2 genes were associated with a disinhibitory symptom count, while 1 SNP in DRD5 was positive for association with the general disinhibitory factor score. Conclusions Our study provides evidence of modest associations between a small number of DA-related genes and AD as well as a range of alcohol-related traits and measures of behavioral disinhibition. While we did conduct gene-based correction for multiple testing, we did not correct for multiple traits because the traits are correlated. However, false-positive findings remain possible, so our results must be interpreted with caution. PMID:21083670

78 FR 72836 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-04

... airplanes. This proposed AD was prompted by multiple reports of cracking in the overwing frames. This proposed AD would require repetitive inspections for cracking in the overwing frames, and corrective... a severed frame and might increase the loading of adjacent frames, resulting in damage to the...

78 FR 52870 - Airworthiness Directives; Beechcraft Corporation Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... the front spar cap angles and hat section structure of the vertical stabilizer. This proposed AD would require inspections of the vertical stabilizer spar angles and hat section for cracks with corrective... information identified in this proposed AD, contact Beechcraft Corporation at address: 10511 E. Central...

77 FR 17327 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011-1087; Directorate Identifier 2011-NM-032-AD; Amendment 39-16967; AD 2012-04-11] RIN 2120-AA64 Airworthiness Directives; Airbus Airplanes Correction In rule document 2012-5859 appearing on pages 14679-14681...

78 FR 9455 - Agency Information Collection (eBenefits Portal) Activity Under OMB Review; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

... DEPARTMENT OF VETERANS AFFAIRS [OMB Control No. 2900-0737] Agency Information Collection (e... error. The notice incorrectly identified the responsible VA organization. This document corrects that error by removing ``Office of Information and Technology'' and adding, in its place, ``Veterans Benefits...

76 FR 16235 - Corporate Credit Unions, Technical Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 707 RIN 3133-AD58 Corporate Credit Unions... 2010, NCUA issued technical corrections to its corporate credit union rule, published in the Federal... October 2010, NCUA published a comprehensive overhaul to its corporate credit union rule, 12 CFR part 704...

Added Diagnostic Value of Cerebrospinal Fluid Biomarkers for Differential Dementia Diagnosis in an Autopsy-Confirmed Cohort.

PubMed

Niemantsverdriet, Ellis; Feyen, Bart F E; Le Bastard, Nathalie; Martin, Jean-Jacques; Goeman, Johan; De Deyn, Peter Paul; Bjerke, Maria; Engelborghs, Sebastiaan

2018-01-01

Differential dementia diagnosis remains a challenge due to overlap of clinical profiles, which often results in diagnostic doubt. Determine the added diagnostic value of cerebrospinal fluid (CSF) biomarkers for differential dementia diagnosis as compared to autopsy-confirmed diagnosis. Seventy-one dementia patients with autopsy-confirmed diagnoses were included in this study. All neuropathological diagnoses were established according to standard neuropathological criteria and consisted of Alzheimer's disease (AD) or other dementias (NONAD). CSF levels of Aβ1 - 42, T-tau, and P-tau181 were determined and interpreted based on the IWG-2 and NIA-AA criteria, separately. A panel of three neurologists experienced with dementia made clinical consensus dementia diagnoses. Clinical and CSF biomarker diagnoses were compared to the autopsy-confirmed diagnoses. Forty-two patients (59%) had autopsy-confirmed AD, whereas 29 patients (41%) had autopsy-confirmed NONAD. Of the 24 patients with an ambiguous clinical dementia diagnosis, a correct diagnosis would have been established in 67% of the cases applying CSF biomarkers in the context of the IWG-2 or the NIA-AA criteria respectively. AD CSF biomarkers have an added diagnostic value in differential dementia diagnosis and can help establishing a correct dementia diagnosis in case of ambiguous clinical dementia diagnoses.

Glucose-6-phosphate transporter gene therapy corrects metabolic and myeloid abnormalities in glycogen storage disease type Ib mice

PubMed Central

Yiu, Wai Han; Pan, Chi-Jiunn; Allamarvdasht, Mohammad; Kim, So Youn; Chou, Janice Y.

2008-01-01

Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the glucose-6-phosphate transporter (G6PT), an endoplasmic reticulum-associated transmembrane protein that is ubiquitously expressed. GSD-Ib patients suffer from disturbed glucose homeostasis and myeloid dysfunctions. To evaluate the feasibility of gene replacement therapy for GSD-Ib, we have infused adenoviral (Ad) vector containing human G6PT (Ad-hG6PT) into G6PT-deficient (G6PT-/-) mice that manifest symptoms characteristics of the human disorder. Ad-hG6PT-infusion restores significant levels of G6PT mRNA expression in the liver, bone marrow, and spleen and corrects metabolic as well as myeloid abnormalities in G6PT-/- mice. The G6PT-/- mice receiving gene therapy exhibit improved growth; normalized serum profiles for glucose, cholesterol, triglyceride, uric acid, and lactic acid; and reduced hepatic glycogen deposition. The therapy also corrects neutropenia and lowers the elevated serum levels of granulocyte colony stimulating factor. The development of bone and spleen in the infused G6PT-/- mice is improved and accompanied by increased cellularity and normalized myeloid progenitor cell frequencies in both tissues. This effective use of gene therapy to correct metabolic imbalances and myeloid dysfunctions in GSD-Ib mice holds promise for the future of gene therapy in humans. PMID:17006547

78 FR 38550 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... skin just above certain lap splice locations is subject to widespread fatigue damage. This AD requires... necessary. We are issuing this AD to detect and correct fatigue cracking of the fuselage skin, which could... skin just above certain lap splice locations is subject to widespread fatigue damage. We are issuing...

77 FR 24355 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-24

... cracks found in the Web pockets of the wing center section (WCS) spanwise beams. This AD requires repetitive detailed inspections and high frequency eddy current inspections for cracks of the WCS spanwise beams, and repair if necessary. We are issuing this AD to detect and correct cracking in the WCS...

76 FR 36995 - Requirements for Taxpayers Filing Form 5472; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-24

... * * * 0 Par. 2. Section 1.6038A-1T is amended by adding paragraph (o) to read as follows: Sec. 1.6038A-1T... section expires on June 10, 2014. * * * * * 0 Par. 3. Section 1.6038A-2T is amended by adding paragraph (i...

78 FR 78694 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... all Airbus Model A330-200 and -300 series airplanes, and Model A340-200 and -300 series airplanes. AD..., and corrective actions if needed. This new AD expands the applicability, reduces the compliance time... the comment received. Request To Change Compliance Time US Airways requested that we change the...

77 FR 55681 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... prompted by reports of stress corrosion cracking in the chord segments made from 7079 aluminum in the... repairing discrepancies if necessary. We are issuing this AD to detect and correct stress corrosion and/or... America Code 55: Stabilizers. (e) Unsafe Condition This AD was prompted by reports of stress corrosion...

78 FR 68360 - Airworthiness Directives; Rolls-Royce plc Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-14

... Airworthiness Directives; Rolls-Royce plc Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT... turbofan engines. The AD number is incorrect in the Regulatory text. This document corrects that error. In... turbofan engines. As published, the AD number 2013-19-17 under Sec. 39.13 [Amended], is incorrect. No other...

78 FR 51055 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... a report of corrosion of the components of the main landing gear (MLG) retraction actuator found in... related pins. This AD requires inspection of the MLG retraction actuator components; corrective actions if necessary; and, for certain retraction actuators, installation of a new jam nut. We are issuing this AD to...

77 FR 29212 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

... Company Model 777 airplanes. This AD was prompted by reports of fractured and missing latch pin retention... inspections for fractured or missing latch pin retention bolts, replacement of existing titanium bolts with... AD to detect and correct fractured and missing latch pin retention bolts, which could result in...

78 FR 26712 - Airworthiness Directives; Eurocopter France Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2013... could result in loss of control of the helicopter. DATES: We must receive comments on this proposed AD... issued EASA AD No. 2011-0154, dated August 22, 2011, to correct an unsafe condition for Eurocopter Model...

78 FR 51053 - Airworthiness Directives; Beechcraft Corporation and Hawker Beechcraft Corporation

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... of elevator balance weights becoming loose or failing because the balance weight material was under strength and did not meet material specifications. This AD requires inspections of elevator balance weights and replacement of defective elevator balance weights. We are issuing this AD to correct the unsafe...

78 FR 42893 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... the passenger oxygen masks are longer than the specified length, possibly leading to inactive oxygen masks in an emergency. This proposed AD would require replacing certain oxygen mask lanyards. We propose this AD to detect and correct lanyards of incorrect length, which might not activate the flow of oxygen...

78 FR 27314 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... found in the crew oxygen system due to the use of incorrect pressure testing procedures during manufacturing. This proposed AD would require cleaning the crew oxygen system. We are proposing this AD to detect and correct oil contaminants, which could cause an ignition and result in a fire in the oxygen...

Providing Location Security in Vehicular Ad Hoc Networks

ERIC Educational Resources Information Center

Yan, Gongjun

2010-01-01

Location is fundamental information in Vehicular Ad-hoc Networks (VANETs). Almost all VANET applications rely on location information. Therefore it is of importance to ensure location information integrity, meaning that location information is original (from the generator), correct (not bogus or fabricated) and unmodified (value not changed). We…

77 FR 11791 - Airworthiness Directives; Saab AB, Saab Aerosystems Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... installation wiring. For the reasons described above, this [EASA] AD requires a one- time [detailed] inspection... installation, and if corrosion is found repairing each affected harness braid or replacing each affected component and/or wiring harness. We are proposing this AD to detect and correct corrosion of critical system...

78 FR 7647 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... gouges, scratches, and corrosion, and replacing the trunnions if necessary; and adding serial numbers and... section. We are issuing this AD to detect and correct cracking, gouges, scratches, and corrosion of the... trunnions and upper and lower pins for gouges, scratches, and corrosion, and replacing if necessary; and...

75 FR 59062 - Airworthiness Directives; The Cessna Aircraft Company Model 750 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... elevators and left and right horizontal stabilizer. For all airplanes, this new AD requires replacing the... inspecting the inboard-hinge brackets of the left and right elevators for cracking and doing related investigative and corrective actions if necessary. For certain airplanes, this new AD requires inspecting for...

77 FR 14342 - Polyvinyl Alcohol From Taiwan: Correction to Notice of Opportunity To Request Administrative Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... DEPARTMENT OF COMMERCE International Trade Administration [A-583-841] Polyvinyl Alcohol From Taiwan: Correction to Notice of Opportunity To Request Administrative Review AGENCY: Import Administration, International Trade Administration, Department of Commerce. FOR FURTHER INFORMATION CONTACT: Dustin Ross, AD/CVD Operations, Office 1, Import...

76 FR 47529 - Customer Clearing Documentation and Timing of Acceptance for Clearing; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Parts 1, 23, and 39 RIN 3038-AD51 Customer Clearing Documentation and Timing of Acceptance for Clearing; Correction AGENCY: Commodity Futures Trading Commission... published in the Federal Register of August 1, 2011, regarding Customer Clearing Documentation and Timing of...

78 FR 74009 - Floodplain Management and Protection of Wetlands; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

...] RIN 2501-AD51 Floodplain Management and Protection of Wetlands; Correction AGENCY: Office of the... governing the protection of wetlands and floodplains. Upon publication, HUD discovered that it inadvertently... by calling the Federal Relay Service at 800-877-8339 (this is a toll-free number). SUPPLEMENTARY...

The relationship between alcohol taxes and binge drinking: evaluating new tax measures incorporating multiple tax and beverage types.

PubMed

Xuan, Ziming; Chaloupka, Frank J; Blanchette, Jason G; Nguyen, Thien H; Heeren, Timothy C; Nelson, Toben F; Naimi, Timothy S

2015-03-01

U.S. studies contribute heavily to the literature about the tax elasticity of demand for alcohol, and most U.S. studies have relied upon specific excise (volume-based) taxes for beer as a proxy for alcohol taxes. The purpose of this paper was to compare this conventional alcohol tax measure with more comprehensive tax measures (incorporating multiple tax and beverage types) in analyses of the relationship between alcohol taxes and adult binge drinking prevalence in U.S. states. Data on U.S. state excise, ad valorem and sales taxes from 2001 to 2010 were obtained from the Alcohol Policy Information System and other sources. For 510 state-year strata, we developed a series of weighted tax-per-drink measures that incorporated various combinations of tax and beverage types, and related these measures to state-level adult binge drinking prevalence data from the Behavioral Risk Factor Surveillance System surveys. In analyses pooled across all years, models using the combined tax measure explained approximately 20% of state binge drinking prevalence, and documented more negative tax elasticity (-0.09, P = 0.02 versus -0.005, P = 0.63) and price elasticity (-1.40, P < 0.01 versus -0.76, P = 0.15) compared with models using only the volume-based tax. In analyses stratified by year, the R-squares for models using the beer combined tax measure were stable across the study period (P = 0.11), while the R-squares for models rely only on volume-based tax declined (P < 0.0). Compared with volume-based tax measures, combined tax measures (i.e. those incorporating volume-based tax and value-based taxes) yield substantial improvement in model fit and find more negative tax elasticity and price elasticity predicting adult binge drinking prevalence in U.S. states. © 2014 Society for the Study of Addiction.

The relationship between alcohol taxes and binge drinking: evaluating new tax measures incorporating multiple tax and beverage types

PubMed Central

Xuan, Ziming; Chaloupka, Frank J.; Blanchette, Jason G.; Nguyen, Thien H.; Heeren, Timothy C.; Nelson, Toben F.; Naimi, Timothy S.

2015-01-01

Aims U.S. studies contribute heavily to the literature about the tax elasticity of demand for alcohol, and most U.S. studies have relied upon specific excise (volume-based) taxes for beer as a proxy for alcohol taxes. The purpose of this paper was to compare this conventional alcohol tax measure with more comprehensive tax measures (incorporating multiple tax and beverage types) in analyses of the relationship between alcohol taxes and adult binge drinking prevalence in U.S. states. Design Data on U.S. state excise, ad valorem and sales taxes from 2001 to 2010 were obtained from the Alcohol Policy Information System and other sources. For 510 state-year strata, we developed a series of weighted tax-per-drink measures that incorporated various combinations of tax and beverage types, and related these measures to state-level adult binge drinking prevalence data from the Behavioral Risk Factor Surveillance System surveys. Findings In analyses pooled across all years, models using the combined tax measure explained approximately 20% of state binge drinking prevalence, and documented more negative tax elasticity (−0.09, P=0.02 versus −0.005, P=0.63) and price elasticity (−1.40, P<0.01 versus −0.76, P=0.15) compared with models using only the volume-based tax. In analyses stratified by year, the R-squares for models using the beer combined tax measure were stable across the study period (P=0.11), while the R-squares for models rely only on volume-based tax declined (P<0.01). Conclusions Compared with volume-based tax measures, combined tax measures (i.e. those incorporating volume-based tax and value-based taxes) yield substantial improvement in model fit and find more negative tax elasticity and price elasticity predicting adult binge drinking prevalence in U.S. states. PMID:25428795

A 3D inversion for all-space magnetotelluric data with static shift correction

NASA Astrophysics Data System (ADS)

Zhang, Kun

2017-04-01

Base on the previous studies on the static shift correction and 3D inversion algorithms, we improve the NLCG 3D inversion method and propose a new static shift correction method which work in the inversion. The static shift correction method is based on the 3D theory and real data. The static shift can be detected by the quantitative analysis of apparent parameters (apparent resistivity and impedance phase) of MT in high frequency range, and completed correction with inversion. The method is an automatic processing technology of computer with 0 cost, and avoids the additional field work and indoor processing with good results. The 3D inversion algorithm is improved (Zhang et al., 2013) base on the NLCG method of Newman & Alumbaugh (2000) and Rodi & Mackie (2001). For the algorithm, we added the parallel structure, improved the computational efficiency, reduced the memory of computer and added the topographic and marine factors. So the 3D inversion could work in general PC with high efficiency and accuracy. And all the MT data of surface stations, seabed stations and underground stations can be used in the inversion algorithm.

Optimal JPWL Forward Error Correction Rate Allocation for Robust JPEG 2000 Images and Video Streaming over Mobile Ad Hoc Networks

NASA Astrophysics Data System (ADS)

Agueh, Max; Diouris, Jean-François; Diop, Magaye; Devaux, François-Olivier; De Vleeschouwer, Christophe; Macq, Benoit

2008-12-01

Based on the analysis of real mobile ad hoc network (MANET) traces, we derive in this paper an optimal wireless JPEG 2000 compliant forward error correction (FEC) rate allocation scheme for a robust streaming of images and videos over MANET. The packet-based proposed scheme has a low complexity and is compliant to JPWL, the 11th part of the JPEG 2000 standard. The effectiveness of the proposed method is evaluated using a wireless Motion JPEG 2000 client/server application; and the ability of the optimal scheme to guarantee quality of service (QoS) to wireless clients is demonstrated.

Entanglement entropy of ABJM theory and entropy of topological black hole

NASA Astrophysics Data System (ADS)

Nian, Jun; Zhang, Xinyu

2017-07-01

In this paper we discuss the supersymmetric localization of the 4D N = 2 offshell gauged supergravity on the background of the AdS4 neutral topological black hole, which is the gravity dual of the ABJM theory defined on the boundary {S}^1× H^2 . We compute the large- N expansion of the supergravity partition function. The result gives the black hole entropy with the logarithmic correction, which matches the previous result of the entanglement entropy of the ABJM theory up to some stringy effects. Our result is consistent with the previous on-shell one-loop computation of the logarithmic correction to black hole entropy. It provides an explicit example of the identification of the entanglement entropy of the boundary conformal field theory with the bulk black hole entropy beyond the leading order given by the classical Bekenstein-Hawking formula, which consequently tests the AdS/CFT correspondence at the subleading order.

78 FR 23465 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...-mill areas on the crown skin panels. This AD requires repetitive inspections for cracking of the fuselage skin at certain locations at chem-mill areas, and repair if necessary. We are issuing this AD to detect and correct fatigue cracking of the skin panel at the specified chem-mill step locations, which...

78 FR 25369 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... at chem-mill areas on the crown skin panels. This AD requires repetitive inspections for cracking of the fuselage skin at certain locations at chem-mill areas, and repair if necessary. We are issuing this AD to detect and correct fatigue cracking of the skin panel at the specified chem-mill step...

77 FR 57536 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

... chem-mill areas on the crown skin panels. This proposed AD would require repetitive inspections for cracking of the fuselage skin at certain locations at chem-mill areas, and repair if necessary. We are proposing this AD to detect and correct fatigue cracking of the skin panel at the specified chem-mill step...

75 FR 5689 - Airworthiness Directives; Turbomeca Arriel 2B and 2B1 Turboshaft Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

...We are adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory continuing airworthiness information (MCAI) issued by an aviation authority of another country to identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as:

75 FR 68179 - Airworthiness Directives; Austro Engine GmbH Model E4 Diesel Piston Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

...We are adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory continuing airworthiness information (MCAI) issued by an aviation authority of another country to identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as:

77 FR 28238 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... adaptor and the wing skin. This AD requires performing an electrical bonding test between the gravity fill re-fuel adaptor and the top skin panels on the left-hand and right-hand wings, and if necessary... repairing the gravity fuel adaptor if any corrosion is found. We are issuing this AD to detect and correct...

77 FR 63714 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

.... ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... instructions and doing the work specified in those instructions. We are issuing this AD to detect and correct..., Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Kelly...

76 FR 9498 - Airworthiness Directives; The Boeing Company Model 737-300, -400, and -500 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-18

... installed, repetitive inspections for corrosion and indications of corrosion on affected carriage spindles... repetitive inspections. This AD results from reports of corrosion found on carriage spindles that are located on the outboard trailing edge flaps. We are issuing this AD to detect and correct corrosion of the...

75 FR 15357 - Airworthiness Directives; The Boeing Company Model 767 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-29

... airplanes. This proposed AD would require repetitive inspections to detect fatigue cracking in the upper... this AD to detect and correct fatigue cracking in the upper wing skin at the fastener holes common to... October 28, 1999. Further Boeing analysis has determined the cracks to be a result of fatigue due to...

78 FR 63858 - Airworthiness Directives; Bell Helicopter Textron, Inc. (Bell) Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Administration (FAA), DOT. ACTION: Final rule. SUMMARY: We are superseding Airworthiness Directive (AD) 2009-05... affected part-numbered main rotor yoke (yoke) on its data plate, reducing the retirement life of the... shows the retirement life should be reduced on certain yokes. We are issuing this AD to correct the...

77 FR 41041 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-12

... terminal ``A'' of the electrically heated flight deck window 1. This AD requires repetitive inspections for damage of the electrical connections at terminal ``A'' of the left and right flight deck window 1, and corrective actions if necessary. This AD also allows for replacing a flight deck window 1 with a new improved...

75 FR 60669 - Airworthiness Directives; Hawker Beechcraft Corporation (Type Certificate Previously Held by...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

... rulemaking (NPRM). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain Model 400A... left and right pylon firewall structures, and corrective actions if necessary. This proposed AD results from reports of missing sealant on the left and right pylon firewall structures. We are proposing this...

76 FR 13543 - Airworthiness Directives; The Boeing Company Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

...We propose to adopt a new airworthiness directive (AD) for the products listed above. This proposed AD would require a detailed inspection to detect distress and existing repairs to the leading edge structure of the vertical stabilizer at the splice at Station Zfs = 52.267; repetitive inspections for cracking in the front spar cap forward flanges of the vertical stabilizer, and either the aft flanges or side skins; repetitive inspections for loose and missing fasteners; and related investigative and corrective actions if necessary. This proposed AD was prompted by reports of cracked vertical stabilizer skin, a severed front spar cap, elongated fastener holes at the leading edge of the vertical stabilizer, and a cracked front spar web and front spar cap bolt holes in the vertical stabilizer. We are proposing this AD to detect and correct such cracking damage, which could result in the structure being unable to support limit load, and could lead to the loss of the vertical stabilizer.

Causality constraints on corrections to the graviton three-point coupling

DOE PAGES

Camanho, Xián O.; Edelstein, José D.; Maldacena, Juan; ...

2016-02-03

In this paper, we consider higher derivative corrections to the graviton three-point coupling within a weakly coupled theory of gravity. Lorentz invariance allows further structures beyond the one present in the Einstein theory. We argue that these are constrained by causality. We devise a thought experiment involving a high energy scattering process which leads to causality violation if the graviton three-point vertex contains the additional structures. This violation cannot be fixed by adding conventional particles with spins J ≤ 2. But, it can be fixed by adding an in finite tower of extra massive particles with higher spins, J > 2. In AdS theories this implies a constraint on the conformal anomaly coefficients |more » $$\\frac{a-c}{c}$$|≲ $$\\frac{1}{2}$$ $${^Δ}_{gap}$$ in terms of Δgap, the dimension of the lightest single trace operator with spin J > 2. Lastly, for inflation, or de Sitter-like solutions, it indicates the existence of massive higher spin particles if the gravity wave non-gaussianity deviates significantly from the one computed in the Einstein theory.« less

Holographic definition of points and distances

NASA Astrophysics Data System (ADS)

Czech, Bartłomiej; Lamprou, Lampros

2014-11-01

We discuss the way in which field theory quantities assemble the spatial geometry of three-dimensional anti-de Sitter space (AdS3). The field theory ingredients are the entanglement entropies of boundary intervals. A point in AdS3 corresponds to a collection of boundary intervals which is selected by a variational principle we discuss. Coordinates in AdS3 are integration constants of the resulting equation of motion. We propose a distance function for this collection of points, which obeys the triangle inequality as a consequence of the strong subadditivity of entropy. Our construction correctly reproduces the static slice of AdS3 and the Ryu-Takayanagi relation between geodesics and entanglement entropies. We discuss how these results extend to quotients of AdS3 —the conical defect and the BTZ geometries. In these cases, the set of entanglement entropies must be supplemented by other field theory quantities, which can carry the information about lengths of nonminimal geodesics.

Simple Decision-Analytic Functions of the AUC for Ruling Out a Risk Prediction Model and an Added Predictor.

PubMed

Baker, Stuart G

2018-02-01

When using risk prediction models, an important consideration is weighing performance against the cost (monetary and harms) of ascertaining predictors. The minimum test tradeoff (MTT) for ruling out a model is the minimum number of all-predictor ascertainments per correct prediction to yield a positive overall expected utility. The MTT for ruling out an added predictor is the minimum number of added-predictor ascertainments per correct prediction to yield a positive overall expected utility. An approximation to the MTT for ruling out a model is 1/[P (H(AUC model )], where H(AUC) = AUC - {½ (1-AUC)} ½ , AUC is the area under the receiver operating characteristic (ROC) curve, and P is the probability of the predicted event in the target population. An approximation to the MTT for ruling out an added predictor is 1 /[P {(H(AUC Model:2 ) - H(AUC Model:1 )], where Model 2 includes an added predictor relative to Model 1. The latter approximation requires the Tangent Condition that the true positive rate at the point on the ROC curve with a slope of 1 is larger for Model 2 than Model 1. These approximations are suitable for back-of-the-envelope calculations. For example, in a study predicting the risk of invasive breast cancer, Model 2 adds to the predictors in Model 1 a set of 7 single nucleotide polymorphisms (SNPs). Based on the AUCs and the Tangent Condition, an MTT of 7200 was computed, which indicates that 7200 sets of SNPs are needed for every correct prediction of breast cancer to yield a positive overall expected utility. If ascertaining the SNPs costs $500, this MTT suggests that SNP ascertainment is not likely worthwhile for this risk prediction.

77 FR 57990 - Interest Rate Risk Policy and Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... NATIONAL CREDIT UNION ADMINISTRATION 12 CFR Part 741 RIN 3133-AD66 Interest Rate Risk Policy and Program Correction In rule document 2012-02091, appearing on pages 55155-5167 in the issue of Thursday, February 2, 2012, make the following corrections: 1. On page 5157, in the second column, in the first line...

76 FR 4569 - Implementing the Whistleblower Provisions of Section 23 of the Commodity Exchange Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 165 RIN Number 3038-AD04 Implementing the Whistleblower Provisions of Section 23 of the Commodity Exchange Act Correction In proposed rule document 2010-29022, beginning on page 75728 in the issue of Monday, December 6, 2010, make the following correction...

76 FR 53326 - Airworthiness Directives; Eurocopter France (ECF) Model EC120B Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

... also requires modifying the emergency switch electrical wiring and performing tests to ensure correct... the RFM after modifying the emergency switch electrical wiring and performing tests to ensure correct... likely to exist or develop on other helicopters of the same type design. Differences Between This AD and...

76 FR 7508 - National Flood Insurance Program, Policy Wording Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... unintentionally omitted words in this final rule. DATES: This rule is effective March 14, 2011. ADDRESSES: The... until the final rule's effective date of December 31, 2000. The words ``Coverage for'' do not... in Appendix A. FEMA proposed to correct the paragraph by adding the words ``Coverage for'' at the...

76 FR 1983 - Airworthiness Directives; The Boeing Company Model MD-11 and MD-11F Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

... assemblies of the tail tank fuel system, a wiring change, and corrective actions if necessary. This AD also requires, for certain airplanes, a general visual inspection for correct installation of the self-adhering high-temperature electrical insulation tape; installation of a wire assembly support bracket and...

78 FR 47154 - Core Principles and Other Requirements for Swap Execution Facilities; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 37 RIN 3038-AD18 Core Principles and Other... this chapter. Appendix B to Part 37--Guidance on, and Acceptable Practices in, Compliance With Core Principles [Corrected] 2. On page 33600, in the second column, under the heading Core Principle 3 of Section...

Author Correction to: Pooled Analyses of Phase III Studies of ADS-5102 (Amantadine) Extended-Release Capsules for Dyskinesia in Parkinson's Disease.

PubMed

Elmer, Lawrence W; Juncos, Jorge L; Singer, Carlos; Truong, Daniel D; Criswell, Susan R; Parashos, Sotirios; Felt, Larissa; Johnson, Reed; Patni, Rajiv

2018-04-01

An Online First version of this article was made available online at http://link.springer.com/journal/40263/onlineFirst/page/1 on 12 March 2018. An error was subsequently identified in the article, and the following correction should be noted.

Additional Term in the Webb-Pearman-Leuning Correction due to Surface Heating From an Open-Path Gas Analyzer

NASA Astrophysics Data System (ADS)

Burba, G. G.; Anderson, D. J.; Xu, L.; McDermitt, D. K.

2006-12-01

One laboratory and two field experiments were conducted between September 2005 and September 2006 to investigate the impact of an added heat flux in the sample path of the LI-7500 CO2/H2O gas analyzer caused by the difference in temperatures between the ambient air and the surface of the instrument. Contribution of heat dissipated from the internal instrument electronics toward the instrument surface was substantial, especially in cold conditions. In the environmental chamber, surface heating ranged from about 0 °C above ambient, at air temperatures above +40 °C, to about 7 °C, at an air temperature of -25 °C. In the field, daytime temperature differences were overall smaller than in the chamber due to convective cooling by the wind and some long-wave cooling, despite the added sunlight contribution. However, considerable temperature gradients (up to 2 °C per 1mm) were still observed over the lower window of the LI-7500, suggesting strong sensible heat fluxes above the instrument surface. The nighttime situation was different due to strong long-wave cooling of some parts of the instrument, partially (and sometimes, fully) offsetting effects of the electronics heating in the other parts. The concept of an added heat flux term in the Web-Pearman-Leuning correction is revisited, and effect of the instrument surface heating on the CO2 flux measurements is examined. The proposed concept is presented in detail, along with resulted corrections to the originally computed flux. Field data are examined separately for daytime and nighttime cases, and on hourly and seasonal time scales. Significant reduction in the apparent CO2 uptake during off-season periods was observed as a result of applying correction due to the added heat, while fluxes during the growing season have not been noticeably affected. The correction also resulted in the elimination of most of the wrong signs from the off-season open- path CO2 fluxes, in considerable reduction in variability of the data, elimination of the difference between measurements made with the LI-6262 and the LI-7500, and in a significant improvement in off-season integrations of CO2 exchange. A framework was created to develop a site-specific practical correction due to instrument surface heating. The concept may provide a basis for further research in the area of instrument temperature affecting the measurement of the open-path fluxes. Proposed correction may be useful for future CO2 flux research, and it can also be applied to pre-existing data today.

Documentation for the machine-readable version of the Smithsonian Astrophysical Observatory Star catalogue (SAO) version 1984

NASA Technical Reports Server (NTRS)

Roman, N. G.; Warren, W. H., Jr.

1984-01-01

An updated, corrected and extended machine readable version of the Smithsonian Astrophysical Observatory star catalog (SAO) is described. Published and unpublished errors discovered in the previous version have been corrected, and multiple star and supplemental BD identifications added to stars where more than one SAO entry has the same Durchmusterung number. Henry Draper Extension (HDE) numbers have been added for stars found in both volumes of the extension. Data for duplicate SAO entries (those referring to the same star) have been blanked out, but the records themselves have been retained and flagged so that sequencing and record count are identical to the published catalog.

Diagnosis of Atopic Dermatitis: Mimics, Overlaps, and Complications

PubMed Central

Siegfried, Elaine C.; Hebert, Adelaide A.

2015-01-01

Atopic dermatitis (AD) is one of the most common skin diseases affecting infants and children. A smaller subset of adults has persistent or new-onset AD. AD is characterized by pruritus, erythema, induration, and scale, but these features are also typical of several other conditions that can mimic, coexist with, or complicate AD. These include inflammatory skin conditions, infections, infestations, malignancies, genetic disorders, immunodeficiency disorders, nutritional disorders, graft-versus-host disease, and drug eruptions. Familiarity of the spectrum of these diseases and their distinguishing features is critical for correct and timely diagnosis and optimal treatment. PMID:26239454

Thermodynamics of Einstein-Born-Infeld black holes with negative cosmological constant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miskovic, Olivera; Olea, Rodrigo; INFN, Sezione di Milano, Via Celoria 16, I-20133, Milano

2008-06-15

We study the thermodynamics associated to topological black hole solutions of AdS gravity coupled to nonlinear electrodynamics (Born-Infeld) in any dimension, using a background-independent regularization prescription for the Euclidean action given by boundary terms, which explicitly depend on the extrinsic curvature (Kounterterms series). A finite action principle leads to the correct definition of thermodynamic variables as Noether charges, which satisfy a Smarr-like relation. In particular, for the odd-dimensional case, a consistent thermodynamic description is achieved if the internal energy of the system includes the vacuum energy for AdS spacetime.

Non-Ceruloplasmin Copper Distincts Subtypes in Alzheimer's Disease: a Genetic Study of ATP7B Frequency.

PubMed

Squitti, Rosanna; Ventriglia, Mariacarla; Gennarelli, Massimo; Colabufo, Nicola A; El Idrissi, Imane Ghafir; Bucossi, Serena; Mariani, Stefania; Rongioletti, Mauro; Zanetti, Orazio; Congiu, Chiara; Rossini, Paolo M; Bonvicini, Cristian

2017-01-01

Meta-analyses show that serum copper non-bound-to-ceruloplasmin (non-Cp-Cu) is higher in patients with Alzheimer's disease (AD). ATP7B gene variants associate with AD, modulating the size of non-Cp-Cu pool. However, a dedicated genetic study comparing AD patients after stratification for a copper biomarker to demonstrate the existence of a copper subtype of AD has not yet been carried out. An independent patient sample of 287 AD patients was assessed for non-Cp-Cu serum concentrations, rs1801243, rs1061472, and rs732774 ATP7B genetic variants and the APOE4 genotype. Patients were stratified into two groups based on a non-Cp-Cu cutoff (1.9 μM). Single-locus and haplotype-group analyses were performed to define their frequencies in dependence of the non-Cp-Cu group. The two AD subgroups did not differ regarding age, sex, MMSE score, or APOE4 frequency allele, while they did differ regarding non-Cp-Cu concentrations in serum, allele, genotype, and haplotype frequencies of rs1061472 A > G and rs732774 C > T after multiple testing corrections. AD patients with a GG genotype had a 1.76-fold higher risk of having a non-Cp-Cu higher than 1.9 μmol/L (p = 0.029), and those with a TT genotype for rs732774 C > T of 1.8-fold (p = 0.018). After 100,000 permutations for multiple testing corrections, the haplotype containing the AC alleles appeared more frequently in AD patients with normal non-Cp-Cu [43 vs. 33 %; Pm = 0.03], while the haplotype containing the GT risk alleles appeared more frequently in the higher non-Cp-Cu AD (66 vs. 55 %; Pm = 0.01). Genetic heterogeneity sustains a copper AD metabolic subtype; non-Cp-Cu is a marker of this copper AD.

75 FR 1536 - Airworthiness Directives; The Boeing Company Model 737-600, -700, and -800 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-12

... stringers of the wing center section for drill starts, and applicable related investigative and corrective actions. This AD results from drill starts being found on the free flange of the lower stringers of the... this AD to prevent cracks from propagating from drill starts in the free flange, vertical web, and...

78 FR 68688 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

... fuel transfer system. We are issuing this AD to detect and correct damage to certain fuel booster pumps... problem with the fuel transfer system. The results of the subsequent investigation revealed damage on the... was prompted by a report of an in-flight problem with the fuel transfer system. We are issuing this AD...

75 FR 8554 - Airworthiness Directives; The Boeing Company Model 747-100, -200B, and -200F Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... AD results from reports of fatigue cracking on modified airplanes. We are proposing this AD to detect and correct fatigue cracking in the longitudinal lap joints of the fuselage lower lobe, which could... reports of incidents involving fatigue cracking and corrosion of transport category airplanes that are...

78 FR 6251 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... airplanes. This proposed AD was prompted by reports of cracks and heat damage on pivot joint components... proposing this AD to detect and correct heat damage and cracks in the pivot pin, truck beam lugs, and inner... joint components have been found with cracks or heat damage. There have been 11 such findings on Model...

75 FR 71538 - Airworthiness Directives; Airbus Model A340-500 and A340-600 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

...We are adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory continuing airworthiness information (MCAI) originated by an aviation authority of another country to identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as:

75 FR 2060 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-14

...We are adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory continuing airworthiness information (MCAI) originated by an aviation authority of another country to identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as:

75 FR 54076 - National Flood Insurance Program, Policy Wording Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... Standard Flood Insurance Policy by adding in two unintentionally omitted words. DATES: Comments must be... 44 CFR until the final rule's effective date of December 31, 2000. The words ``Coverage for'' do not... paragraph by adding the words ``Coverage for'' at the beginning of 44 CFR part 61 Appendix A(2) III.B.4...

75 FR 13695 - Airworthiness Directives; Lockheed Martin Corporation/Lockheed Martin Aeronautics Company Model...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

... proposed AD results from a report of fatigue cracking of the wing upper and lower rainbow fittings during... fittings are susceptible to multiple site fatigue damage. We are proposing this AD to detect and correct such fatigue cracks, which could grow large and lead to the failure of the fitting and a catastrophic...

75 FR 39804 - Airworthiness Directives; The Boeing Company Model 757 Airplanes, Model 767 Airplanes, and Model...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

... of the electrical terminal at the left and right flightdeck window 1, and corrective actions if necessary. This AD also allows for replacing the flightdeck window 1 with a new improved flightdeck window... flightdeck window 1. This AD results from several reports of electrical arcs at the terminal blocks of the...

75 FR 3660 - Airworthiness Directives; The Boeing Company Model 757 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... airplanes. This proposed AD would require repetitive inspections for corrosion and cracking in the front... side link support fitting at WS 292. We are proposing this AD to detect and correct such corrosion and... fastener locations common to the side link support fitting at WS 292. This area is not covered by the...

Study of the Influence of Age in 18F-FDG PET Images Using a Data-Driven Approach and Its Evaluation in Alzheimer's Disease.

PubMed

Jiang, Jiehui; Sun, Yiwu; Zhou, Hucheng; Li, Shaoping; Huang, Zhemin; Wu, Ping; Shi, Kuangyu; Zuo, Chuantao; Neuroimaging Initiative, Alzheimer's Disease

2018-01-01

18 F-FDG PET scan is one of the most frequently used neural imaging scans. However, the influence of age has proven to be the greatest interfering factor for many clinical dementia diagnoses when analyzing 18 F-FDG PET images, since radiologists encounter difficulties when deciding whether the abnormalities in specific regions correlate with normal aging, disease, or both. In the present paper, the authors aimed to define specific brain regions and determine an age-correction mathematical model. A data-driven approach was used based on 255 healthy subjects. The inferior frontal gyrus, the left medial part and the left medial orbital part of superior frontal gyrus, the right insula, the left anterior cingulate, the left median cingulate, and paracingulate gyri, and bilateral superior temporal gyri were found to have a strong negative correlation with age. For evaluation, an age-correction model was applied to 262 healthy subjects and 50 AD subjects selected from the ADNI database, and partial correlations between SUVR mean and three clinical results were carried out before and after age correction. All correlation coefficients were significantly improved after the age correction. The proposed model was effective in the age correction of both healthy and AD subjects.

a 3d Information System for the Documentation of Archaeologica L Excavations

NASA Astrophysics Data System (ADS)

Ardissone, P.; Bornaz, L.; Degattis, G.; Domaine, R.

2013-07-01

Documentation of archaeological and cultural heritage sites is at the heart of the archaeological process and an important component in cultural heritage research, presentation and restorations. In 2012 the Superintendence of Cultural Heritage of Aosta Valley - IT (Soprintendenza per i Beni e le Attività Culturali della Region e Autonoma Valle d'Aosta) carried out a complex archaeological excavation in a composite archaeological context, situated an urban background: the Aosta city centre. This archaeological excavation has been characterized by the classical urban archaeological issues: little space, short time, complex stratigraphy. Moreover the investigations have come out several structures and walls that required safety and conservation measures. Ad hoc 3D solutions carried out a complete 3D survey of the area in 10 different time/situations of the Archaeological digs, chosen in collaborations with the archaeological staff. In this way a multi temporal 3D description of the site has been provided for the archaeological analysis and for the project of the restorations activities. The 3D surveys has been carried out integrating GPS, laser scanner technology and photogrammetry. In order to meet the needs of the site, and its complex logistics and to obtain products that guarantee the high quality and detail required for archaeological analysis, we have developed different procedures and methodologies: hdr imaging for 3D model with correct, consistent and uniform colours, noise filtering and people filtering, for the removal of interference between laser instrument and object of the survey, Advanced laser scanner triangulation, in order to consider both artificial and natural tie points, for a correct registration of a huge amount of scans. Single image orientation on 3D data, in order to integrate the laser data with data coming from digital photogrammetry (faster on the field than the laser scanner survey, than used in certain situations). The results of all these methodologies and procedures will be presented and described in the article. For the documentation of the archaeological excavations and for the management of the conservation activities (condition assessment, planning, and conservation work). Ad Hoc 3D solutions has costumized 2 special plug-ins of its own software platform Ad Hoc: Ad Hoc Archaeology and Ad Hoc Conservation. The software platform integrates a 3D database management system. All information (measurements, plotting, areas of interests…) are organized according to their correct 3D position. They can be queried using attributes, geometric characteristics or their spatial position. The Ad Hoc Archaeology plug-in allows archeologists to fill out UUSS sheets in an internal database, put them in the correct location within the 3D model of the site, define the mutual relations between the UUSS, divide the different archaeological phases. A simple interface will facilitate the construction of the stratigraphic chart (matrix), in a 3D environment as well (matrix 3D). The Ad Hoc Conservation plug-in permits conservators and restorers to create relationships between the different approaches and descriptions of the same parts of the monument, i.e.: between stratigraphyc units or historical phases and architectural components and/or decay pathologies. The 3D DBMS conservation module uses a codified terminology based on "ICOMOS illustrated glossary of stone deterioration" and other glossary. Specific tools permits restorers to compute correctly surfaces and volumes. In this way decay extension and intensity can be measured with high precision and with an high level of detail, for a correct time and costs estimation of each conservation step.

ACT Reporting Category Interpretation Guide: Version 1.0. ACT Working Paper 2016 (05)

ERIC Educational Resources Information Center

Powers, Sonya; Li, Dongmei; Suh, Hongwook; Harris, Deborah J.

2016-01-01

ACT reporting categories and ACT Readiness Ranges are new features added to the ACT score reports starting in fall 2016. For each reporting category, the number correct score, the maximum points possible, the percent correct, and the ACT Readiness Range, along with an indicator of whether the reporting category score falls within the Readiness…

76 FR 31221 - Truth in Lending; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

... remaining portion of the $5,000 and $1,000 balances at the variable rate determined using the 10-point... protected balances. * * * * * Supplement I to Part 226 [Corrected] 0 4. On page 23016, in the first column... applies to a $5,000 balance on a credit card account is a variable rate that is determined by adding a...

The Relationship between Self-Esteem and AD/HD Characteristics in the Serious Juvenile Delinquents in Japan

ERIC Educational Resources Information Center

Matsuura, Naomi; Hashimoto, Toshiaki; Toichi, Motomi

2009-01-01

The purpose of this study was to clarify the following 2 points: (1) whether self-esteem changes after correctional education, and (2) whether attention deficit/hyperactivity characteristics affect self-esteem. The subjects were 118 juveniles (all males) admitted to "A" juvenile correctional facility. Our findings indicated that during…

77 FR 5728 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-06

... between bonding lead and the harness, due to over length of the bonding lead. As the affected wire is not... chafing of the wires, and corrective actions, if necessary. We are proposing this AD to detect and correct contact or chafing of wires and bonding leads which, if not detected could be a source of sparks in the...

75 FR 37765 - Federal Advisory Committee; Military Leadership Diversity Commission (MLDC); Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... Chief Steven A. Hady, Designated Federal Officer, MLDC, at (703) 602-0838, 1851 South Bell Street, Suite... published a notice in the Federal Register on June 18, 2010 (75 FR 34707), announcing a meeting of the... corrects the June 18 notice by adding a closed Administrative Meeting (July 6, 2010) and an agenda for the...

A Directory of Selective Corrections Films.

ERIC Educational Resources Information Center

Lankes, George A.

This directory of selective film titles has been prepared to serve as a ready index to many of the films of potential value for the enrichment of a corrections curriculum. Recognizing that the list is not complete, the directory has been assembled in a manner which allows for adding titles by alphabetic sequence on the blank sides of the pages.…

Cerebral blood flow and freezing of gait in Parkinson's disease.

PubMed

Imamura, K; Okayasu, N; Nagatsu, T

2012-09-01

We investigated the relationship between freezing of gait (FOG) severity in Parkinson's disease (PD) and regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) and evaluated the effect of selegiline therapy. We evaluated 54 patients with PD (FOG positive: 21 patients, and FOG negative: 33 patients) with N-isopropyl-p-[I-123] iodoamphetamine ((123) I-IMP) SPECT and the Unified Parkinson's Disease Rating Scale (UPDRS) part III, Mini-Mental State Examination (MMSE), and Beck Depression Inventory. [Correction added on 18 April 2012, after online publication: In the preceding statement, 55 instead of 54 patients with PD were evaluated, and FOG negative consisted of 34 instead of 33 patients] Furthermore, we examined rCBF in FOG-negative patients treated with levodopa with or without selegiline. Z-values of bilateral Brodmann areas (BA) 10 and 11 and left BA32 showed significant increases in the FOG-positive group compared with the FOG-negative group. [Correction added on 18 April 2012, after online publication: In the preceding statement, Z-values was changed to Z-scores] There were significantly positive correlations between Z-values of these areas and FOG score, especially on both sides of BA11. [Correction added on 18 April 2012, after online publication: In the preceding statement, Z-values was changed to Z-scores] An increase in Z-values in bilateral BA10 and 11 and left BA32 in the levodopa-selegiline treatment group after 1 year was significantly inhibited compared with the levodopa treatment group. [Correction added on 18 April 2012, after online publication: In the preceding statement, left BA32 was changed to right BA32, and Z-values was changed to Z-scores] There was a close relationship between FOG severity in PD and an increase in rCBF in BA 10, 11 and 32. Furthermore, selegiline's FOG prevention effect may be related to maintaining rCBF in these same areas. © 2012 John Wiley & Sons A/S.

Radiological Evaluation of Strategic Structures in Patients with Mild Cognitive Impairment and Early Alzheimer's Disease.

PubMed

Nesteruk, Tomasz; Nesteruk, Marta; Styczyńska, Maria; Barcikowska-Kotowicz, Maria; Walecki, Jerzy

2016-01-01

The aim of the study was to evaluate the diagnostic value of two measurement techniques in patients with cognitive impairment - automated volumetry of the hippocampus, entorhinal cortex, parahippocampal gyrus, posterior cingulate gyrus, cortex of the temporal lobes and corpus callosum, and fractional anisotropy (FA) index measurement of the corpus callosum using diffusion tensor imaging. A total number of 96 patients underwent magnetic resonance imaging study of the brain - 33 healthy controls (HC), 33 patients with diagnosed mild cognitive impairment (MCI) and 30 patients with Alzheimer's disease (AD) in early stage. The severity of the dementia was evaluated with neuropsychological test battery. The volumetric measurements were performed automatically using FreeSurfer imaging software. The measurements of FA index were performed manually using ROI (region of interest) tool. The volumetric measurement of the temporal lobe cortex had the highest correct classification rate (68.7%), whereas the lowest was achieved with FA index measurement of the corpus callosum (51%). The highest sensitivity and specificity in discriminating between the patients with MCI vs. early AD was achieved with the volumetric measurement of the corpus callosum - the values were 73% and 71%, respectively, and the correct classification rate was 72%. The highest sensitivity and specificity in discriminating between HC and the patients with early AD was achieved with the volumetric measurement of the entorhinal cortex - the values were 94% and 100%, respectively, and the correct classification rate was 97%. The highest sensitivity and specificity in discriminating between HC and the patients with MCI was achieved with the volumetric measurement of the temporal lobe cortex - the values were 90% and 93%, respectively, and the correct classification rate was 92%. The diagnostic value varied depending on the measurement technique. The volumetric measurement of the atrophy proved to be the best imaging biomarker, which allowed the distinction between the groups of patients. The volumetric assessment of the corpus callosum proved to be a useful tool in discriminating between the patients with MCI vs. early AD.

Worldsheet scattering in AdS3/CFT2

NASA Astrophysics Data System (ADS)

Sundin, Per; Wulff, Linus

2013-07-01

We confront the recently proposed exact S-matrices for AdS 3/ CFT 2 with direct worldsheet calculations. Utilizing the BMN and Near Flat Space (NFS) expansions for strings on AdS 3 × S 3 × S 3 × S 1 and AdS 3 × S 3 × T 4 we compute both tree-level and one-loop scattering amplitudes. Up to some minor issues we find nice agreement in the tree-level sector. At the one-loop level however we find that certain non-zero tree-level processes, which are not visible in the exact solution, contribute, via the optical theorem, and give an apparent mismatch for certain amplitudes. Furthermore we find that a proposed one-loop modification of the dressing phase correctly reproduces the worldsheet calculation while the standard Hernandez-Lopez phase does not. We also compute several massless to massless processes.

One-Loop One-Point Functions in Gauge-Gravity Dualities with Defects.

PubMed

Buhl-Mortensen, Isak; de Leeuw, Marius; Ipsen, Asger C; Kristjansen, Charlotte; Wilhelm, Matthias

2016-12-02

We initiate the calculation of loop corrections to correlation functions in 4D defect conformal field theories (dCFTs). More precisely, we consider N=4 SYM theory with a codimension-one defect separating two regions of space, x_{3}>0 and x_{3}<0, where the gauge group is SU(N) and SU(N-k), respectively. This setup is made possible by some of the real scalar fields acquiring a nonvanishing and x_{3}-dependent vacuum expectation value for x_{3}>0. The holographic dual is the D3-D5 probe brane system where the D5-brane geometry is AdS_{4}×S^{2} and a background gauge field has k units of flux through the S^{2}. We diagonalize the mass matrix of the dCFT making use of fuzzy-sphere coordinates and we handle the x_{3} dependence of the mass terms in the 4D Minkowski space propagators by reformulating these as standard massive AdS_{4} propagators. Furthermore, we show that only two Feynman diagrams contribute to the one-loop correction to the one-point function of any single-trace operator and we explicitly calculate this correction in the planar limit for the simplest chiral primary. The result of this calculation is compared to an earlier string-theory computation in a certain double scaling limit and perfect agreement is found. Finally, we discuss how to generalize our calculation to any single-trace operator, to finite N, and to other types of observables such as Wilson loops.

76 FR 15800 - Airworthiness Directives; The Boeing Company Model MD-90-30 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... products listed above. This AD requires repetitive inspections for cracking of the left and right upper... by a report of a crack found in the upper skin panel at the aft inboard corner of a right horizontal stabilizer. We are issuing this AD to detect and correct cracks in the upper center skin panels of the...

76 FR 1996 - Airworthiness Directives; M7 Aerospace LP (Type Certificate Previously Held by Fairchild Aircraft...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

... manufacturer of inner glass ply fracture. We are issuing this AD to detect and correct damage to the cockpit...: Discussion We received reports from the windshield manufacturer of inner glass ply fractures found on 19... reports from the windshield manufacturer of inner glass ply fracture. We are issuing this AD to detect and...

76 FR 10288 - Airworthiness Directives; The Boeing Company Model 767-200, -300, -300F, and -400ER Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... and corrosion to an area within five inches of the fail-safe strap. Revision 2 of this service.... The existing AD currently requires inspections to detect cracking or corrosion of the fail-safe straps... corrective actions. Since we issued that AD, we have received additional reports of cracks in 51 fail-safe...

75 FR 1017 - Airworthiness Directives; General Electric Company (GE) CF34-1A, CF34-3A, and CF34-3B Series...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

...) fan blades within compliance times specified in the AD, inspecting the fan blade abradable rub strip on certain engines for wear, inspecting the fan blades on certain engines for cracks, inspecting the.... This ad supersedure requires the same actions but corrects the effectivity for certain fan blades...

76 FR 63167 - Airworthiness Directives; Diamond Aircraft Industries GmbH Airplanes With Supplemental Type...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... airplane weight and balance. We are issuing this AD to correct the unsafe condition on these products... revise hour = $255. weight and balance. According to the manufacturer, all of the costs of this AD may be... weight and balance. (h) Optional Actions If all actions in paragraphs (g)(1), (g)(2), (g)(3), and (g)(4...

76 FR 40262 - Determination of Attainment, Approval and Promulgation of Air Quality Implementation Plans...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

.... Therefore, EPA is correcting this error by adding paragraph (jj) to 40 CFR 52.726 for Illinois. Section 553...: 42 U.S.C. 7401 et seq. Subpart O--Illinois 0 2. Section 52.726 is amended by adding paragraph (jj) to read as follows: Sec. 52.726 Control strategy. Ozone. * * * * * (jj) Determination of attainment. On...

76 FR 40288 - Airworthiness Directives; The Boeing Company Model MD-90-30 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... rulemaking (NPRM). SUMMARY: We propose to adopt a new airworthiness directive (AD) for all Model MD-90-30... cracking on the aft side of the left and right wing rear spar lower caps at station Xrs = 164.000, further.... We are proposing this AD to detect and correct cracking of the left and right rear spar lower caps...

75 FR 70868 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

...: Notice of proposed rulemaking (NPRM). SUMMARY: We propose to adopt a new airworthiness directive (AD) for... electrical terminal at the left and right flightdeck window 1, and corrective actions if necessary. This proposed AD would also allow for replacing the flightdeck window 1 with a new improved flightdeck window...

78 FR 19090 - Airworthiness Directives; Embraer S.A. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-29

...We are adopting a new airworthiness directive (AD) for certain Embraer S.A. Model ERJ 170 and ERJ 190 airplanes. This AD was prompted by a report that high rate discharge (HRD) bottle explosive cartridges of a cargo compartment fire extinguisher system were swapped between the forward and aft cargo compartments. Additional investigation also revealed the possibility of swapping between the electrical connectors of the HRD and low rate discharge (LRD) bottles, and a rotated installation of the HRD bottle. Improper assembly of the fire extinguishing bottle might cause the extinguishing agent to be discharged toward the unselected cargo compartment rather than toward the cargo compartment with fire. This AD requires an inspection of the HRD bottle for correct installation and to determine if the pressure switch is in the correct position, and re-installation if necessary; an inspection of the HRD and LRD bottle discharge heads to determine the part number, and replacement if necessary; and, for certain airplanes, an inspection to identify the HRD and LRD bottle electrical connectors, and relocation if necessary. We are issuing this AD to prevent the inability of the fire extinguishing system to suppress fire.

Improved Correction of IR Loss in Diffuse Shortwave Measurements: An ARM Value-Added Product

DOE Office of Scientific and Technical Information (OSTI.GOV)

Younkin, K; Long, CN

Simple single black detector pyranometers, such as the Eppley Precision Spectral Pyranometer (PSP) used by the Atmospheric Radiation Measurement (ARM) Program, are known to lose energy via infrared (IR) emission to the sky. This is especially a problem when making clear-sky diffuse shortwave (SW) measurements, which are inherently of low magnitude and suffer the greatest IR loss. Dutton et al. (2001) proposed a technique using information from collocated pyrgeometers to help compensate for this IR loss. The technique uses an empirically derived relationship between the pyrgeometer detector data (and alternatively the detector data plus the difference between the pyrgeometer casemore » and dome temperatures) and the nighttime pyranometer IR loss data. This relationship is then used to apply a correction to the diffuse SW data during daylight hours. We developed an ARM value-added product (VAP) called the SW DIFF CORR 1DUTT VAP to apply the Dutton et al. correction technique to ARM PSP diffuse SW measurements.« less

40 CFR Table 6 to Subpart Kkkkk of... - Continuous Compliance With Emission Limitations and Work Practice Standards

Code of Federal Regulations, 2010 CFR

2010-07-01

... or DLS/FF i. If you use a bag leak detection system, initiating corrective action within 1 hour of a bag leak detection system alarm and completing corrective actions in accordance with your OM&M plan... established during the performance test; and iv. If chemicals are added to the scrubber water, collecting the...

75 FR 61977 - Airworthiness Directives; The Boeing Company Model 747-100, 747-200B, and 747-200F Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... fatigue-related skin cracks and corrosion of the skin panel lap joints in the fuselage upper lobe, and... of corrosion, and related investigative and corrective actions. This AD reduces the maximum interval... and correct fatigue cracking and corrosion in the fuselage upper lobe skin lap joints, which could...

76 FR 4224 - Airworthiness Directives; The Boeing Company Model 767-300 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... backup structure at the lower VHF antenna cutout at station 1197 + 99 between stringers 39 left and 39... periphery of the VHF antenna baseplate at station 1197 + 99. We are issuing this AD to detect and correct... lower VHF antenna cutout at station 1197 + 99 between stringers 39L and 39R, and corrective actions if...

Heavy fields and gravity

NASA Astrophysics Data System (ADS)

Goon, Garrett

2017-01-01

We study the effects of heavy fields on 4D spacetimes with flat, de Sitter and anti-de Sitter asymptotics. At low energies, matter generates specific, calculable higher derivative corrections to the GR action which perturbatively alter the Schwarzschild-( A) dS family of solutions. The effects of massive scalars, Dirac spinors and gauge fields are each considered. The six-derivative operators they produce, such as ˜ R 3 terms, generate the leading corrections. The induced changes to horizon radii, Hawking temperatures and entropies are found. Modifications to the energy of large AdS black holes are derived by imposing the first law. An explicit demonstration of the replica trick is provided, as it is used to derive black hole and cosmological horizon entropies. Considering entropy bounds, it's found that scalars and fermions increase the entropy one can store inside a region bounded by a sphere of fixed size, but vectors lead to a decrease, oddly. We also demonstrate, however, that many of the corrections fall below the resolving power of the effective field theory and are therefore untrustworthy. Defining properties of black holes, such as the horizon area and Hawking temperature, prove to be remarkably robust against higher derivative gravitational corrections.

78 FR 79287 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

...We are adopting a new airworthiness directive (AD) for certain Bombardier, Inc. Model CL-600-2C10 (Regional Jet Series 700, 701, & 702), CL-600-2D15 (Regional Jet Series 705), and CL-600-2D24 (Regional Jet Series 900) airplanes. This AD was prompted by a report that traces of oil could be found in the crew oxygen system due to the use of incorrect pressure testing procedures during manufacturing. This AD requires cleaning the crew oxygen system. We are issuing this AD to detect and correct oil contaminants, which could cause an ignition and result in a fire in the oxygen system.

An exact operator that knows its location

NASA Astrophysics Data System (ADS)

Anand, N.; Chen, Hongbin; Fitzpatrick, A. Liam; Kaplan, Jared; Li, Daliang

2018-02-01

We use conformal symmetry to define an AdS3 proto-field ϕ as an exact linear combination of Virasoro descendants of a CFT2 primary operator O . We find that both symmetry considerations and a gravitational Wilson line formalism lead to the same results. The operator ϕ has many desirable properties; in particular it has correlators that agree with gravitational perturbation theory when expanded at large c, and that automatically take the correct form in all vacuum AdS3 geometries, including BTZ black hole backgrounds. In the future it should be possible to use ϕ to probe bulk locality and black hole horizons at a non-perturbative level.

Log corrections to entropy of three dimensional black holes with soft hair

NASA Astrophysics Data System (ADS)

Grumiller, Daniel; Perez, Alfredo; Tempo, David; Troncoso, Ricardo

2017-08-01

We calculate log corrections to the entropy of three-dimensional black holes with "soft hairy" boundary conditions. Their thermodynamics possesses some special features that preclude a naive direct evaluation of these corrections, so we follow two different approaches. The first one exploits that the BTZ black hole belongs to the spectrum of Brown-Henneaux as well as soft hairy boundary conditions, so that the respective log corrections are related through a suitable change of the thermodynamic ensemble. In the second approach the analogue of modular invariance is considered for dual theories with anisotropic scaling of Lifshitz type with dynamical exponent z at the boundary. On the gravity side such scalings arise for KdV-type boundary conditions, which provide a specific 1-parameter family of multi-trace deformations of the usual AdS3/CFT2 setup, with Brown-Henneaux corresponding to z = 1 and soft hairy boundary conditions to the limiting case z → 0+. Both approaches agree in the case of BTZ black holes for any non-negative z. Finally, for soft hairy boundary conditions we show that not only the leading term, but also the log corrections to the entropy of black flowers endowed with affine û (1) soft hair charges exclusively depend on the zero modes and hence coincide with the ones for BTZ black holes.

76 FR 18020 - Airworthiness Directives; Sicma Aero Seat 9140, 9166, 9173, 9174, 9184, 9188, 9196, 91B7, 91B8...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... [email protected]zodiac.com ; Internet http://www.sicma.zodiac.com/en/ . (3) You may review copies of the... adopting a new airworthiness directive (AD) for the products listed above. This AD results from mandatory... identify and correct an unsafe condition on an aviation product. The MCAI describes the unsafe condition as...

Logarithmic black hole entropy corrections and holographic Rényi entropy

NASA Astrophysics Data System (ADS)

Mahapatra, Subhash

2018-01-01

The entanglement and Rényi entropies for spherical entangling surfaces in CFTs with gravity duals can be explicitly calculated by mapping these entropies first to the thermal entropy on hyperbolic space and then, using the AdS/CFT correspondence, to the Wald entropy of topological black holes. Here we extend this idea by taking into account corrections to the Wald entropy. Using the method based on horizon symmetries and the asymptotic Cardy formula, we calculate corrections to the Wald entropy and find that these corrections are proportional to the logarithm of the area of the horizon. With the corrected expression for the entropy of the black hole, we then find corrections to the Rényi entropies. We calculate these corrections for both Einstein and Gauss-Bonnet gravity duals. Corrections with logarithmic dependence on the area of the entangling surface naturally occur at the order GD^0. The entropic c-function and the inequalities of the Rényi entropy are also satisfied even with the correction terms.

False Recognition in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease-Disinhibition or Amnesia?

PubMed

Flanagan, Emma C; Wong, Stephanie; Dutt, Aparna; Tu, Sicong; Bertoux, Maxime; Irish, Muireann; Piguet, Olivier; Rao, Sulakshana; Hodges, John R; Ghosh, Amitabha; Hornberger, Michael

2016-01-01

Episodic memory recall processes in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) can be similarly impaired, whereas recognition performance is more variable. A potential reason for this variability could be false-positive errors made on recognition trials and whether these errors are due to amnesia per se or a general over-endorsement of recognition items regardless of memory. The current study addressed this issue by analysing recognition performance on the Rey Auditory Verbal Learning Test (RAVLT) in 39 bvFTD, 77 AD and 61 control participants from two centers (India, Australia), as well as disinhibition assessed using the Hayling test. Whereas both AD and bvFTD patients were comparably impaired on delayed recall, bvFTD patients showed intact recognition performance in terms of the number of correct hits. However, both patient groups endorsed significantly more false-positives than controls, and bvFTD and AD patients scored equally poorly on a sensitivity index (correct hits-false-positives). Furthermore, measures of disinhibition were significantly associated with false positives in both groups, with a stronger relationship with false-positives in bvFTD. Voxel-based morphometry analyses revealed similar neural correlates of false positive endorsement across bvFTD and AD, with both patient groups showing involvement of prefrontal and Papez circuitry regions, such as medial temporal and thalamic regions, and a DTI analysis detected an emerging but non-significant trend between false positives and decreased fornix integrity in bvFTD only. These findings suggest that false-positive errors on recognition tests relate to similar mechanisms in bvFTD and AD, reflecting deficits in episodic memory processes and disinhibition. These findings highlight that current memory tests are not sufficient to accurately distinguish between bvFTD and AD patients.

Postoperative shoulder imbalance in Lenke Type 1A adolescent idiopathic scoliosis and related factors.

PubMed

Matsumoto, Morio; Watanabe, Kota; Kawakami, Noriaki; Tsuji, Taichi; Uno, Koki; Suzuki, Teppei; Ito, Manabu; Yanagida, Haruhisa; Minami, Shohei; Akazawa, Tsutomu

2014-11-05

The purpose of this study was to investigate the occurrence and factors associated with postoperative shoulder imbalance (PSI) in Lenke type 1A curve. This study included 106 patients with Lenke Type 1A curve who were followed up more than two years after posterior correction surgery. Pedicle screw (PS) constructs were used in 84 patients, and hybrid constructs in 22. The upper instrumented vertebra was rostral to the upper-end vertebra (UEV) in 70 patients, at UEV in 26, and below UEV in 10. The clavicle angle and T1 tilt angle were measured as PSI indicators, and correlations between radiographic parameters of shoulder balance and other radiographic parameters and associations between PSI and clinical parameters were investigated. For statistical analyses, paired and unpaired t-tests were used. The mean Cobb angles of the main and proximal thoracic curves were 54.6 ± 9.5 and 26.7 ± 7.9 degrees before surgery, 14.5 ± 7.5, and 14.9 ± 7.1 at follow-up. Clavicle angle and T1 tilt angle were -2.9 ± 2.8 and -2.6 ± 6.3 before surgery, 2.4 ± 2.8 and 4.4 ± 4.3 immediately after surgery, and 1.8 ± 2.1 and 3.4 ± 5.5 at follow-up. Twenty patients developed distal adding-on. Clavicle angle at follow-up correlated weakly but significantly with preoperative clavicle angle (r = 0.34, p = 0.001) and with the correction rates of the main thoracic curve (r = 0.34, p = 0.001); it correlated negatively with the proximal curve spontaneous correction rate (r=-0.21, p = 0.034). The clavicle angle at follow-up was significantly larger in patients with PS-only constructs (PS 2.1 degrees vs. hybrid 0.9, p = 0.02), and tended to be smaller in patients with distal adding-on (adding-on 1.1 vs. non adding-on 2.0, p = 0.09). PSI was more common with better correction of the main curve (using PS constructs), in patients with a larger preoperative clavicle angle, and with a larger and more rigid proximal curve. Distal adding-on may compensate for PSI.

Movement Correction Method for Human Brain PET Images: Application to Quantitative Analysis of Dynamic [18F]-FDDNP Scans

PubMed Central

Wardak, Mirwais; Wong, Koon-Pong; Shao, Weber; Dahlbom, Magnus; Kepe, Vladimir; Satyamurthy, Nagichettiar; Small, Gary W.; Barrio, Jorge R.; Huang, Sung-Cheng

2010-01-01

Head movement during a PET scan (especially, dynamic scan) can affect both the qualitative and quantitative aspects of an image, making it difficult to accurately interpret the results. The primary objective of this study was to develop a retrospective image-based movement correction (MC) method and evaluate its implementation on dynamic [18F]-FDDNP PET images of cognitively intact controls and patients with Alzheimer’s disease (AD). Methods Dynamic [18F]-FDDNP PET images, used for in vivo imaging of beta-amyloid plaques and neurofibrillary tangles, were obtained from 12 AD and 9 age-matched controls. For each study, a transmission scan was first acquired for attenuation correction. An accurate retrospective MC method that corrected for transmission-emission misalignment as well as emission-emission misalignment was applied to all studies. No restriction was assumed for zero movement between the transmission scan and first emission scan. Logan analysis with cerebellum as the reference region was used to estimate various regional distribution volume ratio (DVR) values in the brain before and after MC. Discriminant analysis was used to build a predictive model for group membership, using data with and without MC. Results MC improved the image quality and quantitative values in [18F]-FDDNP PET images. In this subject population, medial temporal (MTL) did not show a significant difference between controls and AD before MC. However, after MC, significant differences in DVR values were seen in frontal, parietal, posterior cingulate (PCG), MTL, lateral temporal (LTL), and global between the two groups (P < 0.05). In controls and AD, the variability of regional DVR values (as measured by the coefficient of variation) decreased on average by >18% after MC. Mean DVR separation between controls and ADs was higher in frontal, MTL, LTL and global after MC. Group classification by discriminant analysis based on [18F]-FDDNP DVR values was markedly improved after MC. Conclusion The streamlined and easy to use MC method presented in this work significantly improves the image quality and the measured tracer kinetics of [18F]-FDDNP PET images. The proposed MC method has the potential to be applied to PET studies on patients having other disorders (e.g., Down syndrome and Parkinson’s disease) and to brain PET scans with other molecular imaging probes. PMID:20080894

Multiscale deep neural network based analysis of FDG-PET images for the early diagnosis of Alzheimer's disease.

PubMed

Lu, Donghuan; Popuri, Karteek; Ding, Gavin Weiguang; Balachandar, Rakesh; Beg, Mirza Faisal

2018-05-01

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases with a commonly seen prodromal mild cognitive impairment (MCI) phase where memory loss is the main complaint progressively worsening with behavior issues and poor self-care. However, not all individuals clinically diagnosed with MCI progress to AD. A fraction of subjects with MCI either progress to non-AD dementia or remain stable at the MCI stage without progressing to dementia. Although a curative treatment of AD is currently unavailable, it is extremely important to correctly identify the individuals in the MCI phase that will go on to develop AD so that they may benefit from a curative treatment when one becomes available in the near future. At the same time, it would be highly desirable to also correctly identify those in the MCI phase that do not have AD pathology so they may be spared from unnecessary pharmocologic interventions that, at best, may provide them no benefit, and at worse, could further harm them with adverse side-effects. Additionally, it may be easier and simpler to identify the cause of the cognitive impairment in these non-AD cases, and hence proper identification of prodromal AD will be of benefit to these individuals as well. Fluorodeoxy glucose positron emission tomography (FDG-PET) captures the metabolic activity of the brain, and this imaging modality has been reported to identify changes related to AD prior to the onset of structural changes. Prior work on designing classifier using FDG-PET imaging has been promising. Since deep-learning has recently emerged as a powerful tool to mine features and use them for accurate labeling of the group membership of given images, we propose a novel deep-learning framework using FDG-PET metabolism imaging to identify subjects at the MCI stage with presymptomatic AD and discriminate them from other subjects with MCI (non-AD / non-progressive). Our multiscale deep neural network obtained 82.51% accuracy of classification just using measures from a single modality (FDG-PET metabolism data) outperforming other comparable FDG-PET classifiers published in the recent literature. Copyright © 2018 Elsevier B.V. All rights reserved.

Online education improves pediatric residents' understanding of atopic dermatitis.

PubMed

Craddock, Megan F; Blondin, Heather M; Youssef, Molly J; Tollefson, Megha M; Hill, Lauren F; Hanson, Janice L; Bruckner, Anna L

2018-01-01

Pediatricians manage skin conditions such as atopic dermatitis (AD) but report that their dermatologic training is inadequate. Online modules may enhance medical education when sufficient didactic or clinical teaching experiences are lacking. We assessed whether an online module about AD improved pediatric residents' knowledge and changed their clinical management of AD. Target and control cohorts of pediatric residents from two institutions were recruited. Target subjects took a 30-question test about AD early in their residency, reviewed the online module, and repeated the test 6 months and 1 year later. The control subjects, who had 1 year of clinical experience but had not reviewed the online module, also took the test. The mean percentage of correct answers was calculated and compared using two-sided, two-sample independent t tests and repeated-measures analysis of variance. For a subset of participants, clinical documentation from AD encounters was reviewed and 13 practice behaviors were compared using the Fisher exact test. Twenty-five subjects in the target cohort and 29 subjects in the control cohort completed the study. The target cohort improved from 18.0 ± 3.2 to 23.4 ± 3.4 correctly answered questions over 1 year (P < .001). This final value was greater than that of the control cohort (20.7 ± 4.5; P = .01). Meaningful differences in practice behaviors were not seen. Pediatric residents who reviewed an online module about AD demonstrated statistically significant improvement in disease-specific knowledge over time and had statistically significantly higher scores than controls. Online dermatology education may effectively supplement traditional clinical teaching. © 2017 Wiley Periodicals, Inc.

TRIAD IV: Nationwide Survey of Medical Students' Understanding of Living Wills and DNR Orders.

PubMed

Mirarchi, Ferdinando L; Ray, Matthew; Cooney, Timothy

2016-12-01

Living wills are a form of advance directives that help to protect patient autonomy. They are frequently encountered in the conduct of medicine. Because of their impact on care, it is important to understand the adequacy of current medical school training in the preparation of physicians to interpret these directives. Between April and August 2011 of third and fourth year medical students participated in an internet survey involving the interpretation of living wills. The survey presented a standard living will as a "stand-alone," a standard living will with the addition an emergent clinical scenario and then variations of the standard living will that included a code status designation ("DNR," "Full Code," or "Comfort Care"). For each version/ scenario, respondents were asked to assign a code status and choose interventions based on the cases presented. Four hundred twenty-five students from medical schools throughout the country responded. The majority indicated they had received some form of advance directive training and understood the concept of code status and the term "DNR." Based on a stand-alone document, 15% of respondents correctly denoted "full code" as the appropriate code status; adding a clinical scenario yielded negligible improvement. When a code designation was added to the living will, correct code status responses ranged from 68% to 93%, whereas correct treatment decisions ranged from 18% to 78%. Previous training in advance directives had no impact on these results. Our data indicate that the majority of students failed to understand the key elements of a living will; adding a code status designations improved correct responses with the exception of the term DNR. Misunderstanding of advance directives is a nationwide problem and jeopardizes patient safety. Medical School ethics curricula need to be improved to ensure competency with respect to understanding advance directives.

First archeointensity results from Portuguese potteries (1550-1750 AD)

NASA Astrophysics Data System (ADS)

Hartmann, Gelvam A.; Trindade, Ricardo I. F.; Goguitchaichvili, Avto; Etchevarne, Carlos; Morales, Juan; Afonso, Marisa C.

2009-01-01

Geomagnetic field variations at archeomagnetic timescales can be obtained from well-dated heated structures and archeological potsherds. Here, we present the first archeointensity results obtained on Portuguese ceramics (1550 to 1750 AD) collected at Brazilian archeological sites. The results are compared to those obtained from Western Europe and currently available geomagnetic field models. Continuous thermomagnetic and IRM acquisitions curves indicate that Ti-poor titanomagnetite is responsible for the remanence in these ceramic fragments. Five fragments (24 samples) out of twelve analyzed yielded reliable intensity estimates. The row archeointensity data were corrected for TRM anisotropy and cooling rate effect. The mean dipole moments are obtained for three different age intervals: 1550±30 AD, 1600±30 AD and 1750±50 AD. Mean intensities vary from 37.9±4.2 μT to 54.8±7.6 μT in agreement with the previously reported data for 1550 AD and 1750 AD. Relatively weaker, but still highly dispersed, values were obtained for 1600 AD ceramics.

Reheating of the Universe as holographic thermalization

NASA Astrophysics Data System (ADS)

Kawai, Shinsuke; Nakayama, Yu

2016-08-01

Assuming gauge/gravity correspondence we study reheating of the Universe using its holographic dual. Inflaton decay and thermalisation of the decay products correspond to collapse of a spherical shell and formation of a blackhole in the dual anti-de Sitter (AdS) spacetime. The reheating temperature is computed as the Hawking temperature of the developed blackhole probed by a dynamical boundary, and is determined by the inflaton energy density and the AdS radius, with corrections from the dynamics of the shell collapse. For given initial energy density of the inflaton field the holographic model typically gives lower reheating temperature than the instant reheating scenario, while it is shown to be safely within phenomenological bounds.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karch, Andreas; Sato, Yoshiki

In this paper we discuss geodesic Witten diagrams in generic holographic conformal field theories with boundary or defect. Boundary CFTs allow two different de-compositions of two-point functions into conformal blocks: boundary channel and ambient channel. Building on earlier work, we derive a holographic dual of the boundary channel decomposition in terms of bulk-to-bulk propagators on lower dimensional AdS slices. In the situation in which we can treat the boundary or defect as a perturbation around pure AdS spacetime, we obtain the leading corrections to the two-point function both in boundary and ambient channel in terms of geodesic Witten diagrams whichmore » exactly reproduce the decomposition into corresponding conformal blocks on the field theory side.« less

Adding gauge fields to Kaplan's fermions

NASA Astrophysics Data System (ADS)

Blum, T.; Kärkkäinen, Leo

1994-04-01

We experiment with adding dynamical gauge field to Kaplan (defect) fermions. In the case of U (1) gauge theory we use an inhomogenous Higgs mechanism to restrict the 3d gauge dynamics to a planar 2d defect. In our simulations the 3d theory produce the correct 2d gauge dynamics. We measure fermion propagators with dynamical gauge fields. They posses the correct chiral structure. The fermions at the boundary of the support of the gauge field (waveguide) are non-chiral, and have a mass two times heavier than the chiral modes. Moreover, these modes cannot be excited by a source at the defect; implying that they are dynamically decoupled. We have also checked that the anomaly relation is fullfilled for the case of a smooth external gauge field.

Geometry and supersymmetry of heterotic warped flux AdS backgrounds

NASA Astrophysics Data System (ADS)

Beck, S.; Gutowski, J.; Papadopoulos, G.

2015-07-01

We classify the geometries of the most general warped, flux AdS backgrounds of heterotic supergravity up to two loop order in sigma model perturbation theory. We show under some mild assumptions that there are no AdS n backgrounds with n ≠ 3. Moreover the warp factor of AdS3 backgrounds is constant, the geometry is a product AdS 3 × M 7 and such solutions preserve, 2, 4, 6 and 8 supersymmetries. The geometry of M 7 has been specified in all cases. For 2 supersymmetries, it has been found that M 7 admits a suitably restricted G 2 structure. For 4 supersymmetries, M 7 has an SU(3) structure and can be described locally as a circle fibration over a 6-dimensional KT manifold. For 6 and 8 supersymmetries, M 7 has an SU(2) structure and can be described locally as a S 3 fibration over a 4-dimensional manifold which either has an anti-self dual Weyl tensor or a hyper-Kähler structure, respectively. We also demonstrate a new Lichnerowicz type theorem in the presence of α' corrections.

77 FR 10952 - Airworthiness Directives; CFM International S.A. Model CFM56 Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

.../N) and serial number (SN) high-pressure compressor (HPC) 4-9 spools installed. In Table 1 of the AD, the HPC 4-9 spool SN GWN05AMO in the 2nd column of the Table is incorrect. This document corrects that...), currently requires removing certain HPC 4-9 spools listed by P/N and SN in the AD. As published, in Table 1...

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease.

PubMed

Cunnane, Stephen C; Courchesne-Loyer, Alexandre; St-Pierre, Valérie; Vandenberghe, Camille; Pierotti, Tyler; Fortier, Mélanie; Croteau, Etienne; Castellano, Christian-Alexandre

2016-03-01

Brain glucose uptake is impaired in Alzheimer's disease (AD). A key question is whether cognitive decline can be delayed if this brain energy defect is at least partly corrected or bypassed early in the disease. The principal ketones (also called ketone bodies), β-hydroxybutyrate and acetoacetate, are the brain's main physiological alternative fuel to glucose. Three studies in mild-to-moderate AD have shown that, unlike with glucose, brain ketone uptake is not different from that in healthy age-matched controls. Published clinical trials demonstrate that increasing ketone availability to the brain via moderate nutritional ketosis has a modest beneficial effect on cognitive outcomes in mild-to-moderate AD and in mild cognitive impairment. Nutritional ketosis can be safely achieved by a high-fat ketogenic diet, by supplements providing 20-70 g/day of medium-chain triglycerides containing the eight- and ten-carbon fatty acids octanoate and decanoate, or by ketone esters. Given the acute dependence of the brain on its energy supply, it seems reasonable that the development of therapeutic strategies aimed at AD mandates consideration of how the underlying problem of deteriorating brain fuel supply can be corrected or delayed. © 2016 New York Academy of Sciences.

"Push-Through" Rod Passage Technique for the Improvement of Lumbar Lordosis and Sagittal Balance in Minimally Invasive Adult Degenerative Scoliosis Surgery.

PubMed

Haque, Raqeeb M; Uddin, Omar M; Ahmed, Yousef; El Ahmadieh, Tarek Y; Hashmi, Sohaib Z; Shah, Amir; Fessler, Richard G

2016-10-01

Traditional open surgical techniques for correction of adult degenerative scoliosis (ADS) are often associated with increased blood loss, postoperative pain, and complications. Minimally invasive (MIS) techniques have been utilized to address these issues; however, concerns regarding improving certain alignment parameters have been raised. A new "push-through" technique for MIS correction of ADS has been developed wherein a rod is bent before its placement into the screw heads and then contoured further to yield improved correction of radiographic parameters. Preoperative and postoperative radiographic measurements of 3 patients who underwent MIS correction of scoliosis using the "push-through" technique were compared with 22 prior patients who had received traditional MIS correction. All patients received staged correction of scoliosis. The first stage involved insertion of lateral lumbar interbodies. Standing x-rays were then evaluated for overall global balance. The second stage involved appropriate MIS facetectomies, facet fusions, posterior transforaminal interbodies at lower lumbar segments, and finally the placement of rods.TECHNIQUE OVERVIEW:: (1) A long rod composed of titanium is bent with a mild lordosis and passed through the extensions of the screw heads cephalad to caudad. (2) The rod is passed fully through the incision so it extrudes from the caudal end of the construct. At this point, further lordosis is bent into the rods. (3) The rod is then pulled back into the appropriate position. (4) The unnecessary cephalad rod is then cut to appropriate length with a circular saw. (5) Rod reducers are then sequentially lowered and tightened to achieve the desired correction. Mean age for all patients was 66.02 years. Preoperative coronal Cobb, sagittal vertical axis (SVA), and pelvic incidence (PI) were similar in all patients, whereas lumbar lordosis (LL) was smaller (15.27 vs. 29.85 degrees, P=0.00389) and pelvic tilt (PT) was larger (37.00 vs. 27.00 degrees, P=0.00011) in "push-through" patients. Postoperatively, "pushthrough" patients experienced greater correction of LL (21.93 vs. 3.70 degrees, P=0.00001), PI-LL (-18.57 vs. -0.26 degrees, P=0.00471), PT (-7.67 vs. -0.40 degrees, P=0.00341), SVA (-40.67 mm vs. 0.95 mm, P=0.05846), and coronal Cobb (-20.23 vs. -18.76 degrees, P=0.75). This new method of contouring a rod enables improved LL. This technique is easy to perform and can be a valuable tool in treating ADS using MIS techniques.

Lipid correction model of carbon stable isotopes for a cosmopolitan predator, spiny dogfish Squalus acanthias.

PubMed

Reum, J C P

2011-12-01

Three lipid correction models were evaluated for liver and white dorsal muscle from Squalus acanthias. For muscle, all three models performed well, based on the Akaike Information Criterion value corrected for small sample sizes (AIC(c) ), and predicted similar lipid corrections to δ(13) C that were up to 2.8 ‰ higher than those predicted using previously published models based on multispecies data. For liver, which possessed higher bulk C:N values compared to that of white muscle, all three models performed poorly and lipid-corrected δ(13) C values were best approximated by simply adding 5.74 ‰ to bulk δ(13) C values. © 2011 The Author. Journal of Fish Biology © 2011 The Fisheries Society of the British Isles.

78 FR 79333 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

...We propose to supersede airworthiness directive (AD) 2000-12- 12, for certain Airbus Model A300, A300-600, and A310 series airplanes. AD 2000-12-12 currently requires inspecting to detect cracks in the lower spar axis of the nacelle pylon between ribs 9 and 10, and repair if necessary. AD 2000-12-12 also provides for optional modification of the pylon, which terminates the inspections for Model A300 series airplanes. Since we issued AD 2000-12-12, we have received reports of cracking of the lower pylon spar after accomplishing the existing modification and have determined that shorter initial and repetitive inspection compliance times are necessary to address the identified unsafe condition. This proposed AD would reduce the initial and repetitive inspection compliance times. We are proposing this AD to detect and correct fatigue cracking, which could result in reduced structural integrity of the lower spar of the nacelle pylon.

Five major controversial issues about fusion level selection in corrective surgery for adolescent idiopathic scoliosis: a narrative review.

PubMed

Lee, Choon Sung; Hwang, Chang Ju; Lee, Dong-Ho; Cho, Jae Hwan

2017-07-01

Shoulder imbalance, coronal decompensation, and adding-on phenomenon following corrective surgery in patients with adolescent idiopathic scoliosis are known to be related to the fusion level selected. Although many studies have assessed the appropriate selection of the proximal and distal fusion level, no definite conclusions have been drawn thus far. We aimed to assess the problems with fusion level selection for corrective surgery in patients with adolescent idiopathic scoliosis, and to enhance understanding about these problems. This study is a narrative review. We conducted a literature search of fusion level selection in corrective surgery for adolescent idiopathic scoliosis. Accordingly, we selected and reviewed five debatable topics related to fusion level selection: (1) selective thoracic fusion; (2) selective thoracolumbar-lumbar (TL-L) fusion; (3) adding-on phenomenon; (4) distal fusion level selection for major TL-L curves; and (5) proximal fusion level selection and shoulder imbalance. Selective fusion can be chosen in specific curve types, although there is a risk of coronal decompensation or adding-on phenomenon. Generally, wider indications for selective fusions are usually associated with more frequent complications. Despite the determination of several indications for selective fusion to avoid such complications, no clear guidelines have been established. Although authors have suggested various criteria to prevent the adding-on phenomenon, no consensus has been reached on the appropriate selection of lower instrumented vertebra. The fusion level selection for major TL-L curves primarily focuses on whether distal fusion can terminate at L3, a topic that remains unclear. Furthermore, because of the presence of several related factors and complications, proximal level selection and shoulder imbalance has been constantly debated and remains controversial from its etiology to its prevention. Although several difficult problems in the diagnosis and treatment of adolescent idiopathic scoliosis have been resolved by understanding its mechanism and via technical advancement, no definite guideline for fusion level selection has been established. A review of five major controversial issues about fusion level selection could provide better understanding of adolescent idiopathic scoliosis. We believe that a thorough validation study of the abovementioned controversial issues can help address them. Copyright © 2017 Elsevier Inc. All rights reserved.

Comparison of line shortening assessed by aerial image and wafer measurements

NASA Astrophysics Data System (ADS)

Ziegler, Wolfram; Pforr, Rainer; Thiele, Joerg; Maurer, Wilhelm

1997-02-01

Increasing number of patterns per area and decreasing linewidth demand enhancement technologies for optical lithography. OPC, the correction of systematic non-linearity in the pattern transfer process by correction of design data is one possibility to tighten process control and to increase the lifetime of existing lithographic equipment. The two most prominent proximity effects to be corrected by OPC are CD variation and line shortening. Line shortening measured on a wafer is up to 2 times larger than full resist simulation results. Therefore, the influence of mask geometry to line shortening is a key item to parameterize lithography. The following paper discusses the effect of adding small serifs to line ends with 0.25 micrometer ground-rule design. For reticles produced on an ALTA 3000 with standard wet etch process, the corner rounding on them mask can be reduced by adding serifs of a certain size. The corner rounding was measured and the effect on line shortening on the wafer is determined. This was investigated by resist measurements on wafer, aerial image plus resist simulation and aerial image measurements on the AIMS microscope.

Does boundary quantum mechanics imply quantum mechanics in the bulk?

NASA Astrophysics Data System (ADS)

Kabat, Daniel; Lifschytz, Gilad

2018-03-01

Perturbative bulk reconstruction in AdS/CFT starts by representing a free bulk field ϕ (0) as a smeared operator in the CFT. A series of 1 /N corrections must be added to ϕ (0) to represent an interacting bulk field ϕ. These corrections have been determined in the literature from several points of view. Here we develop a new perspective. We show that correlation functions involving ϕ (0) suffer from ambiguities due to analytic continuation. As a result ϕ (0) fails to be a well-defined linear operator in the CFT. This means bulk reconstruction can be understood as a procedure for building up well-defined operators in the CFT which thereby singles out the interacting field ϕ. We further propose that the difficulty with defining ϕ (0) as a linear operator can be re-interpreted as a breakdown of associativity. Presumably ϕ (0) can only be corrected to become an associative operator in perturbation theory. This suggests that quantum mechanics in the bulk is only valid in perturbation theory around a semiclassical bulk geometry.

Using a drug facts box to communicate drug benefits and harms: two randomized trials.

PubMed

Schwartz, Lisa M; Woloshin, Steven; Welch, H Gilbert

2009-04-21

Direct-to-consumer prescription drug ads typically fail to provide fundamental information that consumers need to make informed decisions: data on how well the drug works. To see whether providing consumers with a drug facts box-a table quantifying outcomes with and without the drug-improves knowledge and affects judgments about prescription medications. Two randomized, controlled trials conducted between October 2006 and April 2007: a symptom drug box trial using direct-to-consumer ads for a histamine-2 blocker and a proton-pump inhibitor to treat heartburn, and a prevention drug box trial using direct-to-consumer ads for a statin and clopidogrel to prevent cardiovascular events. National sample of U.S. adults identified by random-digit dialing. Adults age 35 to 70 years who completed a mailed survey; the final samples comprised 231 participants with completed surveys in the symptom drug box trial (49% response rate) and 219 in the prevention drug box trial (46% response rate). In both trials, the control group received 2 actual drug ads (including both the front page and brief summary). The drug box group received the same ads, except that the brief summary was replaced by a drug facts box. Choice between drugs (primary outcome of the symptom drug box trial) and accurate perceptions of drug benefits and side effects (primary outcome of the prevention drug box trial). In the symptom drug box trial, 70% of the drug box group and 8% of the control group correctly identified the PPI as being "a lot more effective" than the histamine-2 blocker (P < 0.001), and 80% and 38% correctly recognized that the side effects of the 2 drugs were similar (P < 0.001). When asked what they would do if they had bothersome heartburn and could have either drug for free, 68% of the drug box group and 31% of the control group chose the proton-pump inhibitor, the superior drug (P < 0.001). In the prevention drug box trial, the drug box improved consumers' knowledge of the benefits and side effects of a statin and clopidogrel. For example, 72% of the drug box group and 9% of the control group correctly quantified the benefit (absolute risk reduction) of the statin (P < 0.001). Most of the control participants overestimated this benefit, and 65% did so by a factor of 10 or more. The trials tested drug boxes in only 4 direct-to-consumer ads. If other direct-to-consumer ads were to communicate outcome data better, the effect of the drug box would be reduced. A drug facts box improved U.S. consumers' knowledge of prescription drug benefits and side effects. It resulted in better choices between drugs for current symptoms and corrected the overestimation of benefit in the setting of prevention. National Cancer Institute and Attorney General Consumer and Prescriber Education Program.

The QCD corrections of the process h → ηbZ

NASA Astrophysics Data System (ADS)

Zhu, Rong-Fei; Feng, Tai-Fu; Zhang, Hai-Bin

2018-05-01

We investigate the 125 GeV Higgs boson decay to a pseudoscalar quarkonium ηb and Z boson. We calculate the quantum chromodynamics (QCD) one-loop corrections to the branching ratio of the process, Br(h → ηbZ), both in the Standard Model (SM) and in the two Higgs double models (THDM). Adding the QCD one-loop corrections, the branching ratio of h → ηbZ in the SM is Br(h → ηbZ) = (4.739‑0.244+0.276) × 10‑5. The relative correction of that QCD one-loop level relative to the tree level of Br(h → ηbZ) is around 76% in the SM. Similarly, the relative correction in the THDM also can be around 75%. The key parameter, tan β, can affect the relative correction in the THDM.

Preliminary maintenance experience for DSS 13 unattended operations demonstration. [Deep Space Network

NASA Technical Reports Server (NTRS)

Remer, D. S.; Lorden, G.

1979-01-01

The maintenance data base collected for 15 weeks of recent unattended and automated operation of DSS 13 is summarized. During this period, DSS 13 was receiving spacecraft telemetry while being controlled remotely from JPL in Pasadena. Corrective and preventive maintenance manhours are reported by subsystem for DSS 13 including the equipment added for the automation demonstration. The corrective and preventive maintenance weekly manhours at DSS 13 averaged 22 and 40, respectively. The antenna hydraulic and electronic systems accounted for about half of the preventive and corrective maintenance manhours for a comparable attended DSN station, DSS 11.

Deterministic ion beam material adding technology for high-precision optical surfaces.

PubMed

Liao, Wenlin; Dai, Yifan; Xie, Xuhui; Zhou, Lin

2013-02-20

Although ion beam figuring (IBF) provides a highly deterministic method for the precision figuring of optical components, several problems still need to be addressed, such as the limited correcting capability for mid-to-high spatial frequency surface errors and low machining efficiency for pit defects on surfaces. We propose a figuring method named deterministic ion beam material adding (IBA) technology to solve those problems in IBF. The current deterministic optical figuring mechanism, which is dedicated to removing local protuberances on optical surfaces, is enriched and developed by the IBA technology. Compared with IBF, this method can realize the uniform convergence of surface errors, where the particle transferring effect generated in the IBA process can effectively correct the mid-to-high spatial frequency errors. In addition, IBA can rapidly correct the pit defects on the surface and greatly improve the machining efficiency of the figuring process. The verification experiments are accomplished on our experimental installation to validate the feasibility of the IBA method. First, a fused silica sample with a rectangular pit defect is figured by using IBA. Through two iterations within only 47.5 min, this highly steep pit is effectively corrected, and the surface error is improved from the original 24.69 nm root mean square (RMS) to the final 3.68 nm RMS. Then another experiment is carried out to demonstrate the correcting capability of IBA for mid-to-high spatial frequency surface errors, and the final results indicate that the surface accuracy and surface quality can be simultaneously improved.

Smokeless tobacco product prices and taxation in Bangladesh: Findings from the ITC survey

PubMed Central

Nargis, N; Hussain, AKMG; Fong, GT

2015-01-01

Context Smokeless tobacco use is well-recognized as occupying a significant portion of overall tobacco consumption in Bangladesh. Yet very little is known about the effectiveness of tax and price policy in controlling the use of smokeless tobacco use in the country. Aims The aims of this paper are to examine the price distribution of various smoked and smokeless tobacco products and estimate the effects of changes in the prices of tobacco products on the consumption of smokeless tobacco. Settings and Design The data for this paper came from the Wave 3 ITC Bangladesh (ITC BD) Survey conducted between November 2011 and May 2012. It is a cohort survey of a nationally representative sample of adult tobacco users and non-users in Bangladesh selected using a stratified multistage cluster sampling design. Two measures of smokeless tobacco use are used in the analysis—prevalence of smokeless tobacco use indicating the decision to use smokeless tobacco products, and the frequency of using smokeless tobacco per day indicating intensity of smokeless tobacco use. Methods and Material The regression analysis involves estimation of the demand function for the most widely used smokeless tobacco product in Bangladesh, zarda. Statistical analysis used The descriptive analysis looks at the characteristics of the price distribution of cigarette, bidi, zarda, and gul using the univariate Epanechnikov kernel density estimation. Results It estimates the price elasticity of lower price brands of zarda (the most commonly used smokeless tobacco product in Bangladesh) at -0.64 and of higher-priced brands at -0.39, and the cross-price elasticity of zarda with respect to cigarettes at 0.35. Conclusions The tax increase on smokeless tobacco products needs to be greater than the tax increase on smoked tobacco products to bridge the wide price differential between the two types of products that currently encourages downward substitution and discourages quitting behaviour. Finally, a specific excise system replacing the existing ad valorem excise tax can substantially contribute to the revenue collection performance from smokeless tobacco products. PMID:25526246

A simple but fully nonlocal correction to the random phase approximation

NASA Astrophysics Data System (ADS)

Ruzsinszky, Adrienn; Perdew, John P.; Csonka, Gábor I.

2011-03-01

The random phase approximation (RPA) stands on the top rung of the ladder of ground-state density functional approximations. The simple or direct RPA has been found to predict accurately many isoelectronic energy differences. A nonempirical local or semilocal correction to this direct RPA leaves isoelectronic energy differences almost unchanged, while improving total energies, ionization energies, etc., but fails to correct the RPA underestimation of molecular atomization energies. Direct RPA and its semilocal correction may miss part of the middle-range multicenter nonlocality of the correlation energy in a molecule. Here we propose a fully nonlocal, hybrid-functional-like addition to the semilocal correction. The added full nonlocality is important in molecules, but not in atoms. Under uniform-density scaling, this fully nonlocal correction scales like the second-order-exchange contribution to the correlation energy, an important part of the correction to direct RPA, and like the semilocal correction itself. For the atomization energies of ten molecules, and with the help of one fit parameter, it performs much better than the elaborate second-order screened exchange correction.

Reheating of the Universe as holographic thermalization

DOE PAGES

Kawai, Shinsuke; Nakayama, Yu

2016-06-14

Here, assuming gauge/gravity correspondence we study reheating of the Universe using its holographic dual. Inflaton decay and thermalisation of the decay products correspond to collapse of a spherical shell and formation of a blackhole in the dual anti-de Sitter (AdS) spacetime. The reheating temperature is computed as the Hawking temperature of the developed blackhole probed by a dynamical boundary, and is determined by the inflaton energy density and the AdS radius, with corrections from the dynamics of the shell collapse. For given initial energy density of the inflaton field the holographic model gives significantly lower reheating temperature than the instantmore » reheating scenario, while it is shown to be safely within phenomenological bounds.« less

Reheating of the Universe as holographic thermalization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawai, Shinsuke; Nakayama, Yu

Here, assuming gauge/gravity correspondence we study reheating of the Universe using its holographic dual. Inflaton decay and thermalisation of the decay products correspond to collapse of a spherical shell and formation of a blackhole in the dual anti-de Sitter (AdS) spacetime. The reheating temperature is computed as the Hawking temperature of the developed blackhole probed by a dynamical boundary, and is determined by the inflaton energy density and the AdS radius, with corrections from the dynamics of the shell collapse. For given initial energy density of the inflaton field the holographic model gives significantly lower reheating temperature than the instantmore » reheating scenario, while it is shown to be safely within phenomenological bounds.« less

Boundary holographic Witten diagrams

DOE PAGES

Karch, Andreas; Sato, Yoshiki

2017-09-25

In this paper we discuss geodesic Witten diagrams in generic holographic conformal field theories with boundary or defect. Boundary CFTs allow two different de-compositions of two-point functions into conformal blocks: boundary channel and ambient channel. Building on earlier work, we derive a holographic dual of the boundary channel decomposition in terms of bulk-to-bulk propagators on lower dimensional AdS slices. In the situation in which we can treat the boundary or defect as a perturbation around pure AdS spacetime, we obtain the leading corrections to the two-point function both in boundary and ambient channel in terms of geodesic Witten diagrams whichmore » exactly reproduce the decomposition into corresponding conformal blocks on the field theory side.« less

Holographic entanglement for Chern-Simons terms

NASA Astrophysics Data System (ADS)

Azeyanagi, Tatsuo; Loganayagam, R.; Ng, Gim Seng

2017-02-01

We derive the holographic entanglement entropy contribution from pure and mixed gravitational Chern-Simons(CS) terms in AdS2 k+1. This is done through two different methods: first, by a direct evaluation of CS action in a holographic replica geometry and second by a descent of Dong's derivation applied to the corresponding anomaly polynomial. In lower dimensions ( k = 1 , 2), the formula coincides with the Tachikawa formula for black hole entropy from gravitational CS terms. New extrinsic curvature corrections appear for k ≥ 3: we give explicit and concise expressions for the two pure gravitational CS terms in AdS7 and present various consistency checks, including agreements with the black hole entropy formula when evaluated at the bifurcation surface.

27 CFR 30.32 - Determination of proof obscuration.

Code of Federal Regulations, 2010 CFR

2010-04-01

... added to the temperature corrected hydrometer reading will give the true proof. (c) Distillation method... use of a precision hydrometer and thermometer in accordance with the provisions of § 13.23 to the...

Defluoridation of drinking water by combined electrocoagulation: effects of the molar ratio of alkalinity and fluoride to Al(III).

PubMed

Zhao, Hua-Zhang; Yang, Wei; Zhu, Jun; Ni, Jin-Ren

2009-03-01

The defluoridation efficiency (epsilon(F)) of electrocoagulation (EC) is closely related to the pH level of the F(-)-containing solution. The pH level usually needs to be adjusted by adding acid in order to obtain the highest epsilon(F) for the F(-)-containing groundwater. The use of combined EC (CEC), which is the combination of chemical coagulation with EC, was proposed to remove fluoride from drinking water for the first time in this study. The optimal scheme for the design and operation of CEC were obtained through experiments on the treatment of F(-)-containing groundwater. It was found, with OH(-) being the only alkalinity of the raw water, that the highest efficiency would be obtained when the molar ratio of alkalinity and fluoride to Al(III) (gamma(Alkalinity+F)) was controlled at 3.0. However, when the raw water contained HCO(3)(-) alkalinity, a correction coefficient was needed to correct the concentration of HCO(3)(-) to obtain the optimal defluoridation condition of gamma(Alkalinity+F)=3.0 for CEC. The correction coefficient of HCO(3)(-) concentration was concluded as 0.60 from the experiment. For the practical F(-)-containing groundwater treatment, CEC can achieve similar epsilon(F) as an acid-adding EC process. The consumption of aluminum electrode was decreased in CEC. The energy consumption also declined greatly in CEC, which is less than one third of that in the acid-adding EC process.

76 FR 19278 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... are proposing this AD to detect and correct cracking in the fail-safe interlayer of certain No. 2 and... to detect and correct cracking in the fail-safe interlayer of certain No. 2 and No. 3 glass windows... cracking in the fail-safe interlayer of certain No. 2 and No. 3 glass windows, which could result in loss...

Preventing Fusion Mass Shift Avoids Postoperative Distal Curve Adding-on in Adolescent Idiopathic Scoliosis.

PubMed

Shigematsu, Hideki; Cheung, Jason Pui Yin; Bruzzone, Mauro; Matsumori, Hiroaki; Mak, Kin-Cheung; Samartzis, Dino; Luk, Keith Dip Kei

2017-05-01

Surgery for adolescent idiopathic scoliosis (AIS) is only complete after achieving fusion to maintain the correction obtained intraoperatively. The instrumented or fused segments can be referred to as the "fusion mass". In patients with AIS, the ideal fusion mass strategy has been established based on fulcrum-bending radiographs for main thoracic curves. Ideally, the fusion mass should achieve parallel endplates of the upper and lower instrumented vertebra and correct any "shift" for truncal balance. Distal adding-on is an important element to consider in AIS surgery. This phenomenon represents a progressive increase in the number of vertebrae included distally in the primary curvature and it should be avoided as it is associated with unsatisfactory cosmesis and an increased risk of revision surgery. However, it remains unknown whether any fusion mass shift, or shift in the fusion mass or instrumented segments, affects global spinal balance and distal adding-on after curve correction surgery in patients with AIS. (1) To investigate the relationship among postoperative fusion mass shift, global balance, and distal adding-on phenomenon in patients with AIS; and (2) to identify a cutoff value of fusion mass shift that will lead to distal adding-on. This was a retrospective study of patients with AIS from a single institution. Between 2006 and 2011 we performed 69 selective thoracic fusions for patients with main thoracic AIS. All patients were evaluated preoperatively and at 2 years postoperatively. The Cobb angle between the cranial and caudal endplates of the fusion mass and the coronal shift between them, which was defined as "fusion mass shift", were measured. Patients with a fusion mass Cobb angle greater than 20° were excluded to specifically determine the effect of fusion mass shift on distal adding-on phenomenon. Fusion mass shift was empirically set as 20 mm for analysis. Therefore, of the 69 patients who underwent selective thoracic fusion, only 52 with a fusion mass Cobb angle of 20° or less were recruited for study. We defined patients with a fusion mass shift of 20 mm or less as the balanced group and those with a fusion mass shift greater than 20 mm as the unbalanced group. A receiver operating characteristic (ROC) curve was used to determine the cutoff point of fusion mass shift for adding-on. Of the 52 patients studied, fusion mass shift (> 20 mm) was noted in 11 (21%), and six of those patients had distal adding-on at final followup. Although global spinal balance did not differ significantly between patients with or without fusion mass shift, the occurrence of adding-on phenomenon was significantly higher in the unbalanced group (55% (six of 11 patients), odds ratio [OR], 8.6; 95% CI, 2-39; p < 0.002) than the balanced group (12% [five of 41 patients]). Based on the ROC curve analysis, a fusion mass shift more than 18 mm was observed as the cutoff point for distal adding-on phenomenon (area under the curve, 0.70; 95% CI, 0.5-0.9; likelihood ratio, 5.0; sensitivity, 0.64; specificity, 0.73; positive predictive value, 39% [seven of 18 patients]; negative predictive value, 88% [30 of 34 patients]; OR, 4.8; 95% CI, 1-20; p = 0.02). Our study illustrates the substantial utility of the fulcrum-bending radiograph in determining fusion levels that can avoid fusion mass shift; thereby, underlining its importance in designing personalized surgical strategies for patients with scoliosis. Preoperatively, determining fusion levels by fulcrum-bending radiographs to avoid residual fusion mass shift is imperative. Intraoperatively, any fusion mass shift should be corrected to avoid distal adding-on, reoperation, and elevated healthcare costs. Level II, prognostic study.

CT-based attenuation and scatter correction compared with uniform attenuation correction in brain perfusion SPECT imaging for dementia

NASA Astrophysics Data System (ADS)

Gillen, Rebecca; Firbank, Michael J.; Lloyd, Jim; O'Brien, John T.

2015-09-01

This study investigated if the appearance and diagnostic accuracy of HMPAO brain perfusion SPECT images could be improved by using CT-based attenuation and scatter correction compared with the uniform attenuation correction method. A cohort of subjects who were clinically categorized as Alzheimer’s Disease (n=38 ), Dementia with Lewy Bodies (n=29 ) or healthy normal controls (n=30 ), underwent SPECT imaging with Tc-99m HMPAO and a separate CT scan. The SPECT images were processed using: (a) correction map derived from the subject’s CT scan or (b) the Chang uniform approximation for correction or (c) no attenuation correction. Images were visually inspected. The ratios between key regions of interest known to be affected or spared in each condition were calculated for each correction method, and the differences between these ratios were evaluated. The images produced using the different corrections were noted to be visually different. However, ROI analysis found similar statistically significant differences between control and dementia groups and between AD and DLB groups regardless of the correction map used. We did not identify an improvement in diagnostic accuracy in images which were corrected using CT-based attenuation and scatter correction, compared with those corrected using a uniform correction map.

27 CFR 24.192 - Process and materials.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the kinds and within the limitations prescribed in § 24.182 may be added with yeast or yeast culture to acclimate the yeast and to facilitate the process of secondary fermentation or to correct the wine...

27 CFR 24.192 - Process and materials.

Code of Federal Regulations, 2013 CFR

2013-04-01

... the kinds and within the limitations prescribed in § 24.182 may be added with yeast or yeast culture to acclimate the yeast and to facilitate the process of secondary fermentation or to correct the wine...

27 CFR 24.192 - Process and materials.

Code of Federal Regulations, 2014 CFR

2014-04-01

... the kinds and within the limitations prescribed in § 24.182 may be added with yeast or yeast culture to acclimate the yeast and to facilitate the process of secondary fermentation or to correct the wine...

27 CFR 24.192 - Process and materials.

Code of Federal Regulations, 2011 CFR

2011-04-01

... the kinds and within the limitations prescribed in § 24.182 may be added with yeast or yeast culture to acclimate the yeast and to facilitate the process of secondary fermentation or to correct the wine...

27 CFR 24.192 - Process and materials.

Code of Federal Regulations, 2012 CFR

2012-04-01

... the kinds and within the limitations prescribed in § 24.182 may be added with yeast or yeast culture to acclimate the yeast and to facilitate the process of secondary fermentation or to correct the wine...

75 FR 61345 - Airworthiness Directives; Eclipse Aerospace, Inc. Model EA500 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... faulty integration of hardware and software, which could result in unannunciated, uncommanded changes in..., altitude preselect, and/or transponder codes. We are issuing this AD to correct faulty integration of...

Archeomagnetism of Jesuit Missions in South Brazil (1657-1706 AD) and assessment of the South American database

NASA Astrophysics Data System (ADS)

Poletti, Wilbor; Trindade, Ricardo I. F.; Hartmann, Gelvam A.; Damiani, Nadir; Rech, Raquel M.

2016-07-01

South America contributes only a small fraction of the global archeomagnetic data. Recent work in the region has expanded significantly the previous database with new data being generated from Chile, Argentina, Northeast and Southeast Brazil. We report here new results from Jesuit Missions in South Brazil, at the triple border with Argentina and Paraguay. Our archeological collection comprises a total of 24 fragments of baked clay construction materials from three Jesuit Missions, São Luiz Gonzaga 1657-1687 AD (3 fragments), São João Batista 1667-1697 AD (4 fragments) and Santo Ângelo 1676-1706 AD (17 fragments). Archeointensity determinations were performed with the double-heating technique in its modified form, with pTRM checks and pTRM tail checks. Measurements were complemented by anisotropy and cooling-rate corrections. A total of 24 specimens (11 fragments) passed strict quality selection, corresponding to a success rate of 45%. We also performed an experimental test for the 6-specimen average anisotropy correction technique and we show that it does not correct for the effects of TRM anisotropy. Results were similar within error for the three missions: São Luiz Gonzaga (40.2 ± 2.4 μT), São João Batista (39.1 ± 1.6 μT) and Santo Ângelo (41.1 ± 2.0 μT). These data were then compared with the most reliable data from South America, after a critical assessment of the current database. According to our analysis, only 39 intensity data for the continent can be considered as high-quality, most within the last 700 years; only three data were retained for older periods (800-1100 AD). The filtered data match reasonably well the available models for the past five centuries. A combined curve for South and Southeast Brazil plus Argentina plot systematically below relocated data from NE Brazil and Chile. These differences are likely due to complexities in the geometry of the field in South America not appropriately accounted for by a simple axial dipole. Our analysis highlights the need for high-quality data for the continent.

Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.

PubMed

Ito, Hiroshi; Shinotoh, Hitoshi; Shimada, Hitoshi; Miyoshi, Michie; Yanai, Kazuhiko; Okamura, Nobuyuki; Takano, Harumasa; Takahashi, Hidehiko; Arakawa, Ryosuke; Kodaka, Fumitoshi; Ono, Maiko; Eguchi, Yoko; Higuchi, Makoto; Fukumura, Toshimitsu; Suhara, Tetsuya

2014-04-01

The characteristic neuropathological changes in Alzheimer's disease (AD) are deposition of amyloid senile plaques and neurofibrillary tangles. The (18)F-labeled amyloid tracer, [(18)F]2-[(2-{(E)-2-[2-(dimethylamino)-1,3-thiazol-5-yl]vinyl}-1,3-benzoxazol-6-yl)oxy]-3-fluoropropan-1-ol (FACT), one of the benzoxazole derivatives, was recently developed. In the present study, deposition of amyloid senile plaques was measured by positron emission tomography (PET) with both [(11)C]Pittsburgh compound B (PIB) and [(18)F]FACT in the same subjects, and the regional uptakes of both radiotracers were directly compared. Two PET scans, one of each with [(11)C]PIB and [(18)F]FACT, were performed sequentially on six normal control subjects, two mild cognitive impairment (MCI) patients, and six AD patients. The standardized uptake value ratio of brain regions to the cerebellum was calculated with partial volume correction using magnetic resonance (MR) images to remove the effects of white matter accumulation. No significant differences in the cerebral cortical uptake were observed between normal control subjects and AD patients in [(18)F]FACT studies without partial volume correction, while significant differences were observed in [(11)C]PIB. After partial volume correction, the cerebral cortical uptake was significantly larger in AD patients than in normal control subjects for [(18)F]FACT studies as well as [(11)C]PIB. Relatively lower uptakes of [(11)C]PIB in distribution were observed in the medial side of the temporal cortex and in the occipital cortex as compared with [(18)F]FACT. Relatively higher uptake of [(11)C]PIB in distribution was observed in the frontal and parietal cortices. Since [(18)F]FACT might bind more preferentially to dense-cored amyloid deposition, regional differences in cerebral cortical uptake between [(11)C]PIB and [(18)F]FACT might be due to differences in regional distribution between diffuse and dense-cored amyloid plaque shown in the autoradiographic and histochemical assays of postmortem AD brain sections.

Kahn Bani Sa’ad Correctional Facility, Kahn Bani Sa’ad, Iraq

DTIC Science & Technology

2008-07-25

building (Building No. 07/03): 1. Ground floor columns were tested with a Schmidt hammer devise (measures the elastic properties or strength of...3. First floor columns – Schmidt hammer and ultrasonic tests were conducted on all the first floor columns. The test results showed the strength...Building Nos. 07/02 and 07/01): 1. Ground floor columns – Using a Schmidt hammer device, very few columns showed low strength. Further study and

Association between Primary Caregiver Education and Cognitive and Language Development of Preterm Neonates.

PubMed

Asztalos, Elizabeth V; Church, Paige T; Riley, Patricia; Fajardo, Carlos; Shah, Prakesh S

2017-03-01

Objective  This study aims to explore the association between primary caregiver education and cognitive and language composite scores of the Bayley Scales of Infant and Toddler Development, 3rd ed. (Bayley-III) in preterm infants at 18 to 21 months corrected age. Design  An observational study was performed on preterm infants born before 29 weeks' gestation between 2010 and 2011. Primary caregivers were categorized by their highest education level and cognitive and language composite scores of the Bayley-III were compared among infants between these groups with adjustment for perinatal and neonatal factors. Results  In total, 1,525 infants/caregivers were included in the multivariate analysis. Compared with those with less than a high school education, infants with primary caregivers who received partial college/specialized training displayed higher cognitive (adjusted difference [AD]: 4.6, 95% confidence interval [CI]: 1.8-7.4) and language scores (AD: 4.0, 95% CI: 0.8-7.1); infants with primary caregivers with university graduate education or above also demonstrated higher cognitive (AD: 6.4, 95% CI: 2.6-10.1) and language scores (AD: 9.9, 95% CI: 5.7-14.1). Conclusion  Higher levels of education of the primary caregiver were associated with increased cognitive and language composite scores at 18 to 21 months corrected age in preterm infants. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A model-free method for mass spectrometer response correction. [for oxygen consumption and cardiac output calculation

NASA Technical Reports Server (NTRS)

Shykoff, Barbara E.; Swanson, Harvey T.

1987-01-01

A new method for correction of mass spectrometer output signals is described. Response-time distortion is reduced independently of any model of mass spectrometer behavior. The delay of the system is found first from the cross-correlation function of a step change and its response. A two-sided time-domain digital correction filter (deconvolution filter) is generated next from the same step response data using a regression procedure. Other data are corrected using the filter and delay. The mean squared error between a step response and a step is reduced considerably more after the use of a deconvolution filter than after the application of a second-order model correction. O2 consumption and CO2 production values calculated from data corrupted by a simulated dynamic process return to near the uncorrupted values after correction. Although a clean step response or the ensemble average of several responses contaminated with noise is needed for the generation of the filter, random noise of magnitude not above 0.5 percent added to the response to be corrected does not impair the correction severely.

Intraplacental Gene Therapy with Ad-IGF-1 Corrects Naturally Occurring Rabbit Model of Intrauterine Growth Restriction

PubMed Central

Keswani, Sundeep G.; Balaji, Swathi; Katz, Anna B.; King, Alice; Omar, Khaled; Habli, Mounira; Klanke, Charles

2015-01-01

Abstract Intrauterine growth restriction (IUGR) due to placental insufficiency is a leading cause of perinatal complications for which there is no effective prenatal therapy. We have previously demonstrated that intraplacental injection of adenovirus-mediated insulin-like growth factor-1 (Ad-IGF-1) corrects fetal weight in a murine IUGR model induced by mesenteric uterine artery branch ligation. This study investigated the effect of intraplacental Ad-IGF-1 gene therapy in a rabbit model of naturally occurring IUGR (runt) due to placental insufficiency, which is similar to the human IUGR condition with onset in the early third trimester, brain sparing, and a reduction in liver weight. Laparotomy was performed on New Zealand White rabbits on day 21 of 30 days of gestation and litters were divided into five groups: Control (first position)+phosphate-buffered saline (PBS), control+Ad-IGF-1, runt (third position)+PBS, runt+Ad-IGF-1, and runt+Ad-LacZ. The effect of IGF-1 gene therapy on fetal, placental, liver, heart, lung, and musculoskeletal weights of the growth-restricted pups was examined. Protein expression after gene transfer was seen along the maternal–fetal placenta interface (n=12) 48 hr after gene therapy. There was minimal gene transfer detected in the pups or maternal organs. At term, compared with the normally grown first-position control, the runted third-position pups demonstrated significantly lower fetal, placental, liver, lung, and musculoskeletal weights. The fetal, liver, and musculoskeletal weights were restored to normal by intraplacental Ad-IGF-1 gene therapy (p<0.01), with no change in the placental weight. Intraplacental gene therapy is a novel strategy for the treatment of IUGR caused by placental insufficiency that takes advantage of an organ that will be discarded at birth. Development of nonviral IGF-1 gene delivery using placenta-specific promoters can potentially minimize toxicity to the mother and fetus and facilitate clinical translation of this novel therapy. PMID:25738403

Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

PubMed

Keswani, Sundeep G; Balaji, Swathi; Katz, Anna B; King, Alice; Omar, Khaled; Habli, Mounira; Klanke, Charles; Crombleholme, Timothy M

2015-03-01

Intrauterine growth restriction (IUGR) due to placental insufficiency is a leading cause of perinatal complications for which there is no effective prenatal therapy. We have previously demonstrated that intraplacental injection of adenovirus-mediated insulin-like growth factor-1 (Ad-IGF-1) corrects fetal weight in a murine IUGR model induced by mesenteric uterine artery branch ligation. This study investigated the effect of intraplacental Ad-IGF-1 gene therapy in a rabbit model of naturally occurring IUGR (runt) due to placental insufficiency, which is similar to the human IUGR condition with onset in the early third trimester, brain sparing, and a reduction in liver weight. Laparotomy was performed on New Zealand White rabbits on day 21 of 30 days of gestation and litters were divided into five groups: Control (first position)+phosphate-buffered saline (PBS), control+Ad-IGF-1, runt (third position)+PBS, runt+Ad-IGF-1, and runt+Ad-LacZ. The effect of IGF-1 gene therapy on fetal, placental, liver, heart, lung, and musculoskeletal weights of the growth-restricted pups was examined. Protein expression after gene transfer was seen along the maternal-fetal placenta interface (n=12) 48 hr after gene therapy. There was minimal gene transfer detected in the pups or maternal organs. At term, compared with the normally grown first-position control, the runted third-position pups demonstrated significantly lower fetal, placental, liver, lung, and musculoskeletal weights. The fetal, liver, and musculoskeletal weights were restored to normal by intraplacental Ad-IGF-1 gene therapy (p<0.01), with no change in the placental weight. Intraplacental gene therapy is a novel strategy for the treatment of IUGR caused by placental insufficiency that takes advantage of an organ that will be discarded at birth. Development of nonviral IGF-1 gene delivery using placenta-specific promoters can potentially minimize toxicity to the mother and fetus and facilitate clinical translation of this novel therapy.

Documentation for the machine-readable version of the Henry Draper Catalogue (edition 1985)

NASA Technical Reports Server (NTRS)

Roman, N. G.; Warren, W. H., Jr.

1985-01-01

An updated, corrected and extended machine-readable version of the catalog is described. Published and unpublished errors discovered in the previous version was corrected; letters indicating supplemental stars in the BD have been moved to a new byte to distinguish them from double-star components; and the machine readable portion of The Henry Draper Extension (HDE) (HA 100) was converted to the same format as the main catalog, with additional data added as necessary.

The Altimetric Wet Tropospheric Correction: Progress Since The ERS-1 Mission

NASA Astrophysics Data System (ADS)

Eymard, L.; Obligis, E.

2006-07-01

To correct for the path delay due to humidity in the troposphere, dedicated microwave radiometers have been added to altimeters on ESA and NASA/CNES missions. This paper presents the major issues with calibration and retrieval of the wet tropospheric path d elay s ince E RS1, a s w ell a s n ew developments for in-flight monitoring, retrieval of the path delay over the open ocean and in coastal regions.

Evaluation of Different Power of Near Addition in Two Different Multifocal Intraocular Lenses

PubMed Central

Unsal, Ugur; Baser, Gonen

2016-01-01

Purpose. To compare near, intermediate, and distance vision and quality of vision, when refractive rotational multifocal intraocular lenses with 3.0 diopters or diffractive multifocal intraocular lenses with 2.5 diopters near addition are implanted. Methods. 41 eyes of 41 patients in whom rotational +3.0 diopters near addition IOLs were implanted and 30 eyes of 30 patients in whom diffractive +2.5 diopters near addition IOLs were implanted after cataract surgery were reviewed. Uncorrected and corrected distance visual acuity, intermediate visual acuity, near visual acuity, and patient satisfaction were evaluated 6 months later. Results. The corrected and uncorrected distance visual acuity were the same between both groups (p = 0.50 and p = 0.509, resp.). The uncorrected intermediate and corrected intermediate and near vision acuities were better in the +2.5 near vision added intraocular lens implanted group (p = 0.049, p = 0.005, and p = 0.001, resp.) and the uncorrected near vision acuity was better in the +3.0 near vision added intraocular lens implanted group (p = 0.001). The patient satisfactions of both groups were similar. Conclusion. The +2.5 diopters near addition could be a better choice in younger patients with more distance and intermediate visual requirements (driving, outdoor activities), whereas the + 3.0 diopters should be considered for patients with more near vision correction (reading). PMID:27340560

Added sugars: consumption and associated factors among adults and the elderly. São Paulo, Brazil.

PubMed

Bueno, Milena Baptista; Marchioni, Dirce Maria Lobo; César, Chester Luis Galvão; Fisberg, Regina Mara

2012-06-01

To investigate added sugar intake, main dietary sources and factors associated with excessive intake of added sugar. A population-based household survey was carried out in São Paulo, the largest city in Brazil. Cluster sampling was performed and the study sample comprised 689 adults and 622 elderly individuals. Dietary intake was estimated based on a 24-hour food recall. Usual nutrient intake was estimated by correcting for the within-person variance of intake using the Iowa State University (ISU) method. Linear regression analysis was conducted to identify factors associated with added sugar intake. Average of energy intake (EI) from added sugars was 9.1% (95% CI: 8.9%; 9.4%) among adults and 8.4% (95% CI: 8.2%; 8.7%) among the elderly (p < 0.05). Average added sugar intake (% EI) was higher among women than among men (p < 0.05). Soft drink was the main source of added sugar among adults, while table sugar was the main source of added sugar among the elderly. Added sugar intake increased with age among adults. Moreover, higher socioeconomic level was associated with added sugar intake in the same group. Added sugar intake is higher among younger adults of higher socioeconomic level. Soft drink and table sugar accounted for more than 50% of the sugar consumed.

A Family-Engaged Educational Program for Atopic Dermatitis: A Seven-Year, Multicenter Experience in Daegu-Gyeongbuk, South Korea

PubMed Central

Jang, Yong Hyun; Lee, Jin Sub; Kim, Sang Lim; Song, Chang Hyun; Jung, Hong Dae; Shin, Dong Hoon; Cho, Jae We; Chung, Hyun; Suh, Moo Kyu

2015-01-01

Background It is important to educate families of pediatric patients with atopic dermatitis (AD) so that they have a correct understanding of AD. Objective The purpose of this study is to introduce, evaluate, and improve our family-engaged educational program. Methods Children suffering from AD and their families have participated in a half-day educational program called "AD school" with catchy slogans such as "Enjoy with AD Families!" every year since 2005. Educational lectures were conducted for parents. For children with AD, various entertaining programs were provided. A feedback survey about AD school was administered for the purpose of evaluation. Results A total of 827 people (376 patients and 451 family members) participated in this program over 7 years. On-site surveys showed a positive response (i.e., "excellent" or "good") for the prick test (95.1%), emollient education (78.4%), educational lecture (97.0%), drawing contest and games (90.2%), and recreation (magic show; 99.0%) respectively. Telephone surveys one year later also elicited a positive response. Conclusion We herein introduce the experience of a half-day, family-engaged educational program for AD. Family-engaged education programs for AD such as this AD school encourage and validate family participation in the treatment of their children's AD. PMID:26273152

A Family-Engaged Educational Program for Atopic Dermatitis: A Seven-Year, Multicenter Experience in Daegu-Gyeongbuk, South Korea.

PubMed

Jang, Yong Hyun; Lee, Jin Sub; Kim, Sang Lim; Song, Chang Hyun; Jung, Hong Dae; Shin, Dong Hoon; Cho, Jae We; Chung, Hyun; Suh, Moo Kyu; Kim, Do Won

2015-08-01

It is important to educate families of pediatric patients with atopic dermatitis (AD) so that they have a correct understanding of AD. The purpose of this study is to introduce, evaluate, and improve our family-engaged educational program. Children suffering from AD and their families have participated in a half-day educational program called "AD school" with catchy slogans such as "Enjoy with AD Families!" every year since 2005. Educational lectures were conducted for parents. For children with AD, various entertaining programs were provided. A feedback survey about AD school was administered for the purpose of evaluation. A total of 827 people (376 patients and 451 family members) participated in this program over 7 years. On-site surveys showed a positive response (i.e., "excellent" or "good") for the prick test (95.1%), emollient education (78.4%), educational lecture (97.0%), drawing contest and games (90.2%), and recreation (magic show; 99.0%) respectively. Telephone surveys one year later also elicited a positive response. We herein introduce the experience of a half-day, family-engaged educational program for AD. Family-engaged education programs for AD such as this AD school encourage and validate family participation in the treatment of their children's AD.

78 FR 25377 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

...We are adopting a new airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, -900 and -900ER series airplanes. This AD was prompted by a report of leaking fuel from the wing leading edge area at the inboard end of the number 5 leading edge slat. This AD requires modifying the fluid drain path in the wing leading edge area, forward of the wing front spar, and doing all applicable related investigative and corrective actions; and installing new seal disks on the latches in the fuel shutoff valve access door. We are issuing this AD to prevent flammable fluids from accumulating in the wing leading edge, and draining inboard and onto the engine exhaust nozzle, which could result in a fire.

Lunar Sample Compendium

NASA Technical Reports Server (NTRS)

Meyer, C.

2009-01-01

The Lunar Sample Compendium is a succinct summary of what has been learned from the study of Apollo and Luna samples of the Moon. Basic information is compiled, sample-by-sample, in the form of an advanced catalog in order to provide a basic description of each sample. Information presented is carefully attributed to the original source publication, thus the Compendium also serves as a ready access to the now vast scientific literature pertaining to lunar smples. The Lunar Sample Compendium is a work in progress (and may always be). Future plans include: adding sections on additional samples, adding new thin section photomicrographs, replacing the faded photographs with newly digitized photos from the original negatives, attempting to correct the age data using modern decay constants, adding references to each section, and adding an internal search engine.

Florbetapir F18 PET Amyloid Neuroimaging and Characteristics in Patients With Mild and Moderate Alzheimer Dementia.

PubMed

Degenhardt, Elisabeth K; Witte, Michael M; Case, Michael G; Yu, Peng; Henley, David B; Hochstetler, Helen M; D'Souza, Deborah N; Trzepacz, Paula T

2016-01-01

Clinical diagnosis of Alzheimer disease (AD) is challenging, with a 70.9%-87.3% sensitivity and 44.3%-70.8% specificity, compared with autopsy diagnosis. Florbetapir F18 positron emission tomography (FBP-PET) estimates beta-amyloid plaque density antemortem. Of 2052 patients (≥55 years old) clinically diagnosed with mild or moderate AD dementia from 2 solanezumab clinical trials, 390 opted to participate in a FBP-PET study addendum. We analyzed baseline prerandomization characteristics. A total of 22.4% had negative FBP-PET scans, whereas 72.5% of mild and 86.9% of moderate AD patients had positive results. No baseline clinical variable reliably differentiated negative from positive FBP-PET scan groups. These data confirm the challenges of correctly diagnosing AD without using biomarkers. FBP-PET can aid AD dementia differential diagnosis by detecting amyloid pathology antemortem, even when the diagnosis of AD is made by expert clinicians. Copyright © 2016 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

Publisher Correction: 2D MoS2 as an efficient protective layer for lithium metal anodes in high-performance Li-S batteries

NASA Astrophysics Data System (ADS)

Cha, Eunho; Patel, Mumukshu D.; Park, Juhong; Hwang, Jeongwoon; Prasad, Vish; Cho, Kyeongjae; Choi, Wonbong

2018-06-01

In the version of this Article originally published, a technical error in typesetting led to the traces in Fig. 3a being trimmed and made to overlap. The figure has now been corrected with the traces as supplied by the authors; the original and corrected Fig. 3a are shown below. Also, in the last paragraph of the section "Mechanistic study on Li diffusion in MoS2" the authors incorrectly included the term `high-concentration' in the text "the Li diffusion will be dominated by high-concentration Li migration on the surface of T-MoS2 with a much smaller energy barrier (0.155 eV) to overcome". This term has now been removed from all versions of the Article. Finally, the authors have added an extra figure in the Supplementary Information (Supplementary Fig. 19) to show galvanostatic tests at 1 and 3 mA cm-2 for the MoS2-coated Li symmetric cells. The caption to Fig. 3 of the Article has been amended to reflect this, with the added wording "Galvanostatic tests at 1 and 3 mA cm-2 can be found in Supplementary Fig. 19."

Entanglement entropy with a time-dependent Hamiltonian

NASA Astrophysics Data System (ADS)

Sivaramakrishnan, Allic

2018-03-01

The time evolution of entanglement tracks how information propagates in interacting quantum systems. We study entanglement entropy in CFT2 with a time-dependent Hamiltonian. We perturb by operators with time-dependent source functions and use the replica trick to calculate higher-order corrections to entanglement entropy. At first order, we compute the correction due to a metric perturbation in AdS3/CFT2 and find agreement on both sides of the duality. Past first order, we find evidence of a universal structure of entanglement propagation to all orders. The central feature is that interactions entangle unentangled excitations. Entanglement propagates according to "entanglement diagrams," proposed structures that are motivated by accessory spacetime diagrams for real-time perturbation theory. To illustrate the mechanisms involved, we compute higher-order corrections to free fermion entanglement entropy. We identify an unentangled operator, one which does not change the entanglement entropy to any order. Then, we introduce an interaction and find it changes entanglement entropy by entangling the unentangled excitations. The entanglement propagates in line with our conjecture. We compute several entanglement diagrams. We provide tools to simplify the computation of loop entanglement diagrams, which probe UV effects in entanglement propagation in CFT and holography.

Brady's Geothermal Field - Analysis of Pressure Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, David

*This submission provides corrections to GDR Submissions 844 and 845* Poroelastic Tomography (PoroTomo) by Adjoint Inverse Modeling of Data from Hydrology. The 3 *csv files containing pressure data are the corrected versions of the pressure dataset found in Submission 844. The dataset has been corrected in the sense that the atmospheric pressure has been subtracted from the total pressure measured in the well. Also, the transducers used at wells 56A-1 and SP-2 are sensitive to surface temperature fluctuations. These temperature effects have been removed from the corrected datasets. The 4th *csv file contains corrected version of the pumping data foundmore » in Submission 845. The data has been corrected in the sense that the data from several wells that were used during the PoroTomo deployment pumping tests that were not included in the original dataset has been added. In addition, several other minor changes have been made to the pumping records due to flow rate instrument calibration issues that were discovered.« less

Teachable Moments: When Protests Erupted Following the Publication of an Anti-Reparations Ad in a Campus Newspaper, Brown University President Ruth Simmons Decided Her Community Could Benefit from Taking a Closer Look at the University's Historical Ties to Slavery

ERIC Educational Resources Information Center

Hamilton, Kendra

2005-01-01

It all started as a rather ran-of-the-mill campus controversy over race and slavery: an anti-reparations ad ran in The Brown Daily Herald; students cried foul, formed human chains and demanded "reparations" in the form of free advertising for the opposing side; still others responded with shouts of "political correctness." But then something…

Shooting string holography of jet quenching at RHIC and LHC

DOE PAGES

Ficnar, Andrej; Gubser, Steven S.; Gyulassy, Miklos

2014-10-13

We derive a new formula for jet energy loss using finite endpoint momentum shooting strings initial conditions in SYM plasmas to overcome the difficulties of previous falling string holographic scenarios. We apply the new formula to compute the nuclear modification factor R AA and the elliptic flow parameter v 2 of light hadrons at RHIC and LHC. We show furthermore that Gauss–Bonnet quadratic curvature corrections to the AdS 5 geometry improve the agreement with the recent data.

Shooting string holography of jet quenching at RHIC and LHC

NASA Astrophysics Data System (ADS)

Ficnar, Andrej; Gubser, Steven S.; Gyulassy, Miklos

2014-11-01

We derive a new formula for jet energy loss using finite endpoint momentum shooting strings initial conditions in SYM plasmas to overcome the difficulties of previous falling string holographic scenarios. We apply the new formula to compute the nuclear modification factor RAA and the elliptic flow parameter v2 of light hadrons at RHIC and LHC. We show furthermore that Gauss-Bonnet quadratic curvature corrections to the AdS5 geometry improve the agreement with the recent data.

Physical condition for elimination of ambiguity in conditionally convergent lattice sums

NASA Astrophysics Data System (ADS)

Young, K.

1987-02-01

The conditional convergence of the lattice sum defining the Madelung constant gives rise to an ambiguity in its value. It is shown that this ambiguity is related, through a simple and universal integral, to the average charge density on the crystal surface. The physically correct value is obtained by setting the charge density to zero. A simple and universally applicable formula for the Madelung constant is derived as a consequence. It consists of adding up dipole-dipole energies together with a nontrivial correction term.

Adding liquid feed to a total mixed ration reduces feed sorting behavior and improves productivity of lactating dairy cows.

PubMed

DeVries, T J; Gill, R M

2012-05-01

This study was designed to determine the effect of adding a molasses-based liquid feed (LF) supplement to a total mixed ration (TMR) on the feed sorting behavior and production of dairy cows. Twelve lactating Holstein cows (88.2±19.5 DIM) were exposed, in a crossover design with 21-d periods, to each of 2 treatment diets: 1) control TMR and 2) control TMR with 4.1% dietary dry matter LF added. Dry matter intake (DMI), sorting, and milk yield were recorded for the last 7 d of each treatment period. Milk samples were collected for composition analysis for the last 3 d of each treatment period; these data were used to calculate 4% fat-corrected milk and energy-corrected milk yield. Sorting was determined by subjecting fresh feed and orts samples to particle separation and expressing the actual intake of each particle fraction as a percentage of the predicted intake of that fraction. Addition of LF did not noticeably change the nutrient composition of the ration, with the exception of an expected increase in dietary sugar concentration (from 4.0 to 5.4%). Liquid feed supplementation affected the particle size distribution of the ration, resulting in a lesser amount of short and a greater amount of fine particles. Cows sorted against the longest ration particles on both treatment diets; the extent of this sorting was greater on the control diet (55.0 vs. 68.8%). Dry matter intake was 1.4 kg/d higher when cows were fed the LF diet as compared with the control diet, resulting in higher acid-detergent fiber, neutral-detergent fiber, and sugar intakes. As a result of the increased DMI, cows tended to produce 1.9 kg/d more milk and produced 3.1 and 3.2 kg/d more 4% fat-corrected milk and energy-corrected milk, respectively, on the LF diet. As a result, cows tended to produce more milk fat (0.13 kg/d) and produced more milk protein (0.09 kg/d) on the LF diet. No difference between treatments was observed in the efficiency of milk production. Overall, adding a molasses-based LF to TMR can be used to decrease feed sorting, enhance DMI, and improve milk yield. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Half-BPS Wilson loop and AdS 2/CFT 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giombi, Simone; Roiban, Radu; Tseytlin, Arkady A.

Here, we study correlation functions of local operator insertions on the 1/2-BPS Wilson line in N=4 super Yang–Mills theory. These correlation functions are constrained by the 1d superconformal symmetry pre-served by the 1/2-BPS Wilson line and define a defect CFT 1 living on the line. At strong coupling, a set of elementary operator insertions with protected scaling dimensions correspond to fluctuations of the dual fundamental string in AdS 5×S 5 ending on the line at the boundary and can be thought of as light fields propagating on the AdS 2 worldsheet. We use AdS/CFT techniques to compute the tree-level AdSmore » 2 Witten diagrams describing the strong coupling limit of the four-point functions of the dual operator insertions. Using the OPE, we also extract the leading strong coupling corrections to the anomalous dimensions of the “two-particle” operators built out of elementary excitations. In the case of the circular Wilson loop, we match our results for the 4-point functions of a special type of scalar insertions to the prediction of localization to 2d Yang–Mills theory.« less

Half-BPS Wilson loop and AdS 2/CFT 1

DOE PAGES

Giombi, Simone; Roiban, Radu; Tseytlin, Arkady A.

2017-09-01

Here, we study correlation functions of local operator insertions on the 1/2-BPS Wilson line in N=4 super Yang–Mills theory. These correlation functions are constrained by the 1d superconformal symmetry pre-served by the 1/2-BPS Wilson line and define a defect CFT 1 living on the line. At strong coupling, a set of elementary operator insertions with protected scaling dimensions correspond to fluctuations of the dual fundamental string in AdS 5×S 5 ending on the line at the boundary and can be thought of as light fields propagating on the AdS 2 worldsheet. We use AdS/CFT techniques to compute the tree-level AdSmore » 2 Witten diagrams describing the strong coupling limit of the four-point functions of the dual operator insertions. Using the OPE, we also extract the leading strong coupling corrections to the anomalous dimensions of the “two-particle” operators built out of elementary excitations. In the case of the circular Wilson loop, we match our results for the 4-point functions of a special type of scalar insertions to the prediction of localization to 2d Yang–Mills theory.« less

Thermodynamics of Resonant Scalars in AdS/CFT and implications for QCD

NASA Astrophysics Data System (ADS)

Megías, Eugenio; Valle, Manuel

2016-11-01

We explore the thermodynamics of a simple 5D Einstein-dilaton gravity model with a massive scalar field, with asymptotically AdS behavior in the UV. The holographic renormalization is addressed in details, and analytical results are obtained at high temperatures. We study the power corrections predicted by the model, and compare with lattice data in the deconfined phase of gluodynamics. Finally, it is discussed the role played by the conformal anomaly for integer values of the dimension of the condensate dual to the scalar field. Talk given by E. Megías at the QCD@Work: International Workshop on QCD, 27-30 June 2016, Martina Franca, Italy.

78 FR 49697 - HUD Acquisition Regulations (HUDAR): Correcting Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-15

... final rule that amended the HUDAR to implement miscellaneous changes, which included, for example, removing obsolete and redundant provisions, updating provisions that address the organizational structure of HUD, and adding provisions on contractor record retention. In making the organizational changes...

Towards Linking Anonymous Authorship in Casual Sexual Encounter Ads

PubMed Central

Fries, Jason A.; Segre, Alberto M.; Polgreen, Philip M.

2013-01-01

Objective This paper constructs an authorship-linked collection or corpus of anonymous, sex-seeking ads found on the classifieds website Craigslist. This corpus is then used to validate an authorship attribution approach based on identifying near duplicate text in ad clusters, providing insight into how often anonymous individuals post sex-seeking ads and where they meet for encounters. Introduction The increasing use of the Internet to arrange sexual encounters presents challenges to public health agencies formulating STD interventions, particularly in the context of anonymous encounters. These encounters complicate or break traditional interventions. In previous work [1], we examined a corpus of anonymous personal ads seeking sexual encounters from the classifieds website Craigslist and presented a way of linking multiple ads posted across time to a single author. The key observation of our approach is that some ads are simply reposts of older ads, often updated with only minor textual changes. Under the presumption that these ads, when not spam, originate from the same author, we can use efficient near-duplicate detection techniques to cluster ads within some threshold similarity. Linking ads in this way allows us to preserve the anonymity of authors while still extracting useful information on the frequency with which authors post ads, as well as the geographic regions in which they seek encounters. While this process detects many clusters, the lack of a true corpus of authorship-linked ads makes it difficult to validate and tune the parameters of our system. Fortunately, many ad authors provide an obfuscated telephone number in ad text (e.g., 867–5309 becomes 8sixseven5three oh nine) to bypass Craigslist filters, which prohibit including phone numbers in personal ads. By matching phone numbers of this type across all ads, we can create a corpus of ad clusters known to be written by a single author. This authorship corpus can then be used to evaluate and tune our existing near-duplicate detection system, and in the future identify features for more robust authorship attribution techniques. Methods From 7-1-2009 until 7-1-2011, RSS feeds were collected daily for 8 personal ad categories from 414 sites across the United States, for a total of 67 million ads. To create an anonymous, author-linked corpus, we used a regular expression to identify obfuscated phone numbers in ad text. We measure the ability of near-duplicate detection to link clusters in two ways: 1) detecting all ads in a cluster; and 2) correctly detecting a subset of ads within a single cluster. Ads incorrectly assigned to more than 1 cluster are considered false positives. All results are reported in terms of precision, recall, and F-scores (common information retrieval metrics) across cluster size, expressed as number of ads. Results 652,014 ads contained phone numbers, producing a total of 46,079 authorship-linked ad clusters. For detecting all ads within a cluster, precision ranged from 0.05 to 0.0 and recall from 0.02 to 0.0 for all cluster sizes. For detecting partial clusters, see Figure 1. Conclusions We find that near-duplicate detection alone is insufficient to detect all ads within a cluster. However, we do find that the process can, with high precision and low recall, detect a subset of ads associated with a single author. This follows the intuition that an author’s total set of ads is itself comprised of multiple self-similar subsets. While a near-duplicate detection approach can correctly identify subsets of ads linked to a single author, this process alone cannot attribute multiple clusters to a single author. Future work will explore leveraging additional linguistic features to improve author attribution. (Top) Evaluations for partial cluster detection using the near-duplicate identification approach to linking anonymous authorship in Craigslist ads and (bottom) the distribution of ad cluster sizes.

Validation of Montgomery-Åsberg Rating Scale and Cornell Scale for Depression in Dementia in Brazilian elderly patients.

PubMed

Portugal, Maria da Glória; Coutinho, Evandro Silva Freire; Almeida, Cloyra; Barca, Maria Lage; Knapskog, Anne-Brita; Engedal, Knut; Laks, Jerson

2012-08-01

There are few studies on validation of depression scales in the elderly in Latin America. This study aimed to assess the validity of Montgomery-Åsberg. Depression Rating Scale (MADRS) and Cornell Scale for Depression in Dementia (CSDD) in Brazilian elderly outpatients. A convenience sample of 95 outpatients was diagnosed for dementia and depression according to DSM-IV-TR, ICD-10, and PDC-dAD criteria. Receiver Operating Curves (ROC) were used to calculate the area under the curve (AUC) and to assess MADRS and CSDD cut-offs for each diagnostic criterion. Dementia was diagnosed in 71 of 95 patients. Depression was diagnosed in 35, 30, and 51 patients by ICD-10, DSM-IV, and PDC-dAD, respectively. MADRS cut-off score of 10 correctly diagnosed 67.4% and 66.3% patients as depressed according to DSM-IV and ICD-10. A cut-off of 9 correctly identified 74.7% by PDC-dAD criteria; a CSDD cut-off score of 13 best recognized depression according to DSM-IV and ICD-10. A score of 11 diagnosed depression according to PDC-dAD, while MADRS = 9 recognized depression in dementia. CSDD was more efficient in showing depression in mild than in moderate/severe dementia according to DSM-IV/ICD-10. PDC-dAD behaved nicely for any severity stage. MADRS and CSDD cut-offs of 10 and 13 were the optimal ones to diagnose depression in elderly, respectively. CSDD cut-offs are higher than those found in other countries. Other Latin American studies are needed to compare results with our study.

Depth of word processing in Alzheimer patients and normal controls: a magnetoencephalographic (MEG) study.

PubMed

Walla, P; Püregger, E; Lehrner, J; Mayer, D; Deecke, L; Dal Bianco, P

2005-05-01

Effects related to depth of verbal information processing were investigated in probable Alzheimer's disease patients (AD) and age matched controls. During word encoding sessions 10 patients and 10 controls had either to decide whether the letter "s" appeared in visually presented words (alphabetical decision, shallow encoding), or whether the meaning of each presented word was animate or inanimate (lexical decision, deep encoding). These encoding sessions were followed by test sessions during which all previously encoded words were presented again together with the same number of new words. The task was then to discriminate between repeated and new words. Magnetic field changes related to brain activity were recorded with a whole cortex MEG.5 probable AD patients showed recognition performances above chance level related to both depths of information processing. Those patients and 5 age matched controls were then further analysed. Recognition performance was poorer in probable AD patients compared to controls for both levels of processing. However, in both groups deep encoding led to a higher recognition performance than shallow encoding. We therefore conclude that the performance reduction in the patient group was independent of depth of processing. Reaction times related to false alarms differed between patients and controls after deep encoding which perhaps could already be used for supporting an early diagnosis. The analysis of the physiological data revealed significant differences between correctly recognised repetitions and correctly classified new words (old/new-effect) in the control group which were missing in the patient group after deep encoding. The lack of such an effect in the patient group is interpreted as being due to the respective neuropathology related to probable AD. The present results demonstrate that magnetic field recordings represent a useful tool to physiologically distinguish between probable AD and age matched controls.

Longitudinal MR cortical thinning of individuals and its correlation with PET metabolic reduction: a measurement consistency and correctness studies

NASA Astrophysics Data System (ADS)

Lin, Zhongmin S.; Avinash, Gopal; McMillan, Kathryn; Yan, Litao; Minoshima, Satoshi

2014-03-01

Cortical thinning and metabolic reduction can be possible imaging biomarkers for Alzheimer's disease (AD) diagnosis and monitoring. Many techniques have been developed for the cortical measurement and widely used for the clinical statistical studies. However, the measurement consistency of individuals, an essential requirement for a clinically useful technique, requires proper further investigation. Here we leverage our previously developed BSIM technique 1 to measure cortical thickness and thinning and use it with longitudinal MRI from ADNI to investigate measurement consistency and spatial resolution. 10 normal, 10 MCI, and 10 AD subjects in their 70s were selected for the study. Consistent cortical thinning patterns were observed in all baseline and follow up images. Rapid cortical thinning was shown in some MCI and AD cases. To evaluate the correctness of the cortical measurement, we compared longitudinal cortical thinning with clinical diagnosis and longitudinal PET metabolic reduction measured using 3D-SSP technique2 for the same person. Longitudinal MR cortical thinning and corresponding PET metabolic reduction showed high level pattern similarity revealing certain correlations worthy of further studies. Severe cortical thinning that might link to disease conversion from MCI to AD was observed in two cases. In summary, our results suggest that consistent cortical measurements using our technique may provide means for clinical diagnosis and monitoring at individual patient's level and MR cortical thinning measurement can complement PET metabolic reduction measurement.

Recognition of familiar people with a mobile cloud architecture for Alzheimer patients.

PubMed

Fardoun, Habib M; Mashat, Abdullah A; Ramirez Castillo, Jaime

2017-02-01

This article aims to the evaluation of a prototypal assistive technology for Alzheimer's disease (AD) patients that helps them to remember personal details of familiar people they meet in their daily lives. An architecture is proposed for a personal information system powered by face recognition, where the main AD patient's interaction is performed in a smart watch device and the face recognition is carried out on the Cloud. A prototype was developed to perform some tests in a real-life scenario. The prototype showed correct results as a personal information system based on face recognition. However, usability flaws were identified in the interaction with the smart watch. Our architecture showed correct performance and we realized that it could be introduced in other fields, apart from assistive technology. However, when being targeted to patients with dementia some usability problems appeared, such as difficulties to read information in a small screen or take a proper photo. These problems should be addressed in further research. Implications for Rehabilitation This article presents a prototypal assistive technology for Alzheimer's disease (AD) patients. It targets AD patients to recognize their familiars, especially in medium-advanced stages of the disease. Analysing pictures taken by a smart watch, which the patient carries, the person in front is recognized and information about him is sent to the watch. This technology enables patients to have all the information of any close person, as a remainder, easing their daily lives, improving their self-esteem and stimulating the patient with novel technology.

Assessing the Added Value of Dynamical Downscaling in the Context of Hydrologic Implication

NASA Astrophysics Data System (ADS)

Lu, M.; IM, E. S.; Lee, M. H.

2017-12-01

There is a scientific consensus that high-resolution climate simulations downscaled by Regional Climate Models (RCMs) can provide valuable refined information over the target region. However, a significant body of hydrologic impact assessment has been performing using the climate information provided by Global Climate Models (GCMs) in spite of a fundamental spatial scale gap. It is probably based on the assumption that the substantial biases and spatial scale gap from GCMs raw data can be simply removed by applying the statistical bias correction and spatial disaggregation. Indeed, many previous studies argue that the benefit of dynamical downscaling using RCMs is minimal when linking climate data with the hydrological model, from the comparison of the impact between bias-corrected GCMs and bias-corrected RCMs on hydrologic simulations. It may be true for long-term averaged climatological pattern, but it is not necessarily the case when looking into variability across various temporal spectrum. In this study, we investigate the added value of dynamical downscaling focusing on the performance in capturing climate variability. For doing this, we evaluate the performance of the distributed hydrological model over the Korean river basin using the raw output from GCM and RCM, and bias-corrected output from GCM and RCM. The impacts of climate input data on streamflow simulation are comprehensively analyzed. [Acknowledgements]This research is supported by the Korea Agency for Infrastructure Technology Advancement (KAIA) grant funded by the Ministry of Land, Infrastructure and Transport (Grant 17AWMP-B083066-04).

Quantum statistical relation for black holes in nonlinear electrodynamics coupled to Einstein-Gauss-Bonnet AdS gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miskovic, Olivera; Olea, Rodrigo

2011-03-15

We consider curvature-squared corrections to Einstein-Hilbert gravity action in the form of a Gauss-Bonnet term in D>4 dimensions. In this theory, we study the thermodynamics of charged static black holes with anti-de Sitter (AdS) asymptotics, and whose electric field is described by nonlinear electrodynamics. These objects have received considerable attention in recent literature on gravity/gauge dualities. It is well-known that, within the framework of anti-de Sitter/conformal field theory (AdS/CFT) correspondence, there exists a nonvanishing Casimir contribution to the internal energy of the system, manifested as the vacuum energy for global AdS spacetime in odd dimensions. Because of this reason, wemore » derive a quantum statistical relation directly from the Euclidean action and not from the integration of the first law of thermodynamics. To this end, we employ a background-independent regularization scheme which consists, in addition to the bulk action, of counterterms that depend on both extrinsic and intrinsic curvatures of the boundary (Kounterterm series). This procedure results in a consistent inclusion of the vacuum energy and chemical potential in the thermodynamic description for Einstein-Gauss-Bonnet AdS gravity regardless of the explicit form of the nonlinear electrodynamics Lagrangian.« less

Simplifying mental math: Changing how added sugars are displayed on the nutrition facts label can improve consumer understanding.

PubMed

Khandpur, Neha; Graham, Dan J; Roberto, Christina A

2017-07-01

Proposed variations to Nutrition Facts Labels (NFL) have included the display of added sugars (AS) content, but its impact on consumer understanding is poorly understood. To examine the degree to which different formats for displaying AS influence consumer understanding, perceptions, and purchase intentions. Randomized-controlled online experiment. A sample of 2509 U.S adults. Participants were randomized to 1 of 8 conditions and viewed 10 food or beverage images with either: (1) no label (control); (2) the current NFL (without AS); (3) the proposed NFL without AS; or the proposed NFL with AS in (4) grams, (5) grams and teaspoons, (6) grams and percent Daily Value (%DV), (7) grams with high/medium/low text, or (8) grams with high/medium/low text and %DV. ANCOVAs compared scores on quizzes that assessed the accuracy of judgments about AS, overall nutrition understanding and purchase intentions. Presenting AS in grams plus high/medium/low text with and without %DV led to the highest AS understanding scores (85% and 83% correct, respectively) compared to 70% correct when AS was not on the label or was displayed in grams only (74% correct). Displaying AS in teaspoons did not significantly improve understanding beyond grams alone. Consumers were best able to determine which of two products was healthier when AS was presented as %DV (68% correct) versus displayed in grams alone (60% correct), but %DV did not differ from high/medium/low text or teaspoons. None of the labels influenced purchase intentions relative to no label. Displaying AS on the NFL in grams with high/medium/low text, %DV, or the combination of the two, improved consumer understanding more than presenting it in grams or teaspoons. Copyright © 2017 Elsevier Ltd. All rights reserved.

Upgraded Analytical Model of the Cylinder Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Souers, P. Clark; Lauderbach, Lisa; Garza, Raul

2013-03-15

A Gurney-type equation was previously corrected for wall thinning and angle of tilt, and now we have added shock wave attenuation in the copper wall and air gap energy loss. Extensive calculations were undertaken to calibrate the two new energy loss mechanisms across all explosives. The corrected Gurney equation is recommended for cylinder use over the original 1943 form. The effect of these corrections is to add more energy to the adiabat values from a relative volume of 2 to 7, with low energy explosives having the largest correction. The data was pushed up to a relative volume of aboutmore » 15 and the JWL parameter ω was obtained directly. The total detonation energy density was locked to the v=7 adiabat energy density, so that the Cylinder test gives all necessary values needed to make a JWL.« less

Upgraded Analytical Model of the Cylinder Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Souers, P. Clark; Lauderbach, Lisa; Garza, Raul

2013-03-15

A Gurney-type equation was previously corrected for wall thinning and angle of tilt, and now we have added shock wave attenuation in the copper wall and air gap energy loss. Extensive calculations were undertaken to calibrate the two new energy loss mechanisms across all explosives. The corrected Gurney equation is recommended for cylinder use over the original 1943 form. The effect of these corrections is to add more energy to the adiabat values from a relative volume of 2 to 7, with low energy explosives having the largest correction. The data was pushed up to a relative volume of aboutmore » 15 and the JWL parameter ω was obtained directly. Finally, the total detonation energy density was locked to the v = 7 adiabat energy density, so that the Cylinder test gives all necessary values needed to make a JWL.« less

Dating young geomorphic surfaces using age of colonizing Douglas fir in southwestern Washington and northwestern Oregon, USA

USGS Publications Warehouse

Pierson, T.C.

2007-01-01

Dating of dynamic, young (<500 years) geomorphic landforms, particularly volcanofluvial features, requires higher precision than is possible with radiocarbon dating. Minimum ages of recently created landforms have long been obtained from tree-ring ages of the oldest trees growing on new surfaces. But to estimate the year of landform creation requires that two time corrections be added to tree ages obtained from increment cores: (1) the time interval between stabilization of the new landform surface and germination of the sampled trees (germination lag time or GLT); and (2) the interval between seedling germination and growth to sampling height, if the trees are not cored at ground level. The sum of these two time intervals is the colonization time gap (CTG). Such time corrections have been needed for more precise dating of terraces and floodplains in lowland river valleys in the Cascade Range, where significant eruption-induced lateral shifting and vertical aggradation of channels can occur over years to decades, and where timing of such geomorphic changes can be critical to emergency planning. Earliest colonizing Douglas fir (Pseudotsuga menziesii) were sampled for tree-ring dating at eight sites on lowland (<750 m a.s.l.), recently formed surfaces of known age near three Cascade volcanoes - Mount Rainier, Mount St. Helens and Mount Hood - in southwestern Washington and northwestern Oregon. Increment cores or stem sections were taken at breast height and, where possible, at ground level from the largest, oldest-looking trees at each study site. At least ten trees were sampled at each site unless the total of early colonizers was less. Results indicate that a correction of four years should be used for GLT and 10 years for CTG if the single largest (and presumed oldest) Douglas fir growing on a surface of unknown age is sampled. This approach would have a potential error of up to 20 years. Error can be reduced by sampling the five largest Douglas fir instead of the single largest. A GLT correction of 5 years should be added to the mean ring-count age of the five largest trees growing on the surface being dated, if the trees are cored at ground level. This correction would have an approximate error of ??5 years. If the trees are cored at about 1.4 m above the round surface (breast height), a CTG correction of 11 years should be added to the mean age of the five sampled trees (with an error of about ??7 years).

3D magnetotelluric inversion system with static shift correction and theoretical assessment in oil and gas exploration

NASA Astrophysics Data System (ADS)

Dong, H.; Kun, Z.; Zhang, L.

2015-12-01

This magnetotelluric (MT) system contains static shift correction and 3D inversion. The correction method is based on the data study on 3D forward modeling and field test. The static shift can be detected by the quantitative analysis of apparent parameters (apparent resistivity and impedance phase) of MT in high frequency range, and completed correction with inversion. The method is an automatic processing technology of computer with zero-cost, and avoids the additional field work and indoor processing with good results shown in Figure 1a-e. Figure 1a shows a normal model (I) without any local heterogeneity. Figure 1b shows a static-shifted model (II) with two local heterogeneous bodies (10 and 1000 ohm.m). Figure 1c is the inversion result (A) for the synthetic data generated from model I. Figure 1d is the inversion result (B) for the static-shifted data generated from model II. Figure 1e is the inversion result (C) for the static-shifted data from model II, but with static shift correction. The results show that the correction method is useful. The 3D inversion algorithm is improved base on the NLCG method of Newman & Alumbaugh (2000) and Rodi & Mackie (2001). For the algorithm, we added the frequency based parallel structure, improved the computational efficiency, reduced the memory of computer, added the topographic and marine factors, and added the constraints of geology and geophysics. So the 3D inversion could even work in PAD with high efficiency and accuracy. The application example of theoretical assessment in oil and gas exploration is shown in Figure 1f-i. The synthetic geophysical model consists of five layers (from top to downwards): shale, limestone, gas, oil, groundwater and limestone overlying a basement rock. Figure 1f-g show the 3D model and central profile. Figure 1h shows the centrel section of 3D inversion, the resultsd show a high degree of reduction in difference on the synthetic model. Figure 1i shows the seismic waveform reflects the interfaces of every layer overall, but the relative positions of the interface of the two-way travel time vary, and the interface between limestone and oil at the sides of the section is not reflected. So 3-D MT can make up for the deficiency of the seismic results such as the fake sync-phase axis and multiple waves.

78 FR 9 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-02

... AD adds repetitive inspections for cracking using different inspection methods and inspecting... cracking using different inspection methods and would inspect additional areas, and corrective actions if... an acceptable method for accomplishing the inspections in areas covered by non-terminating repairs as...

77 FR 731 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-06

... mechanism of the horizontal stabilizer trim actuator (HSTA). This AD requires repetitive inspections... trim actuator of the horizontal stabilizer; various modification(s); and corrective actions if... the ball nut and ballscrew and attachment (Gimbal) fittings for the trim actuator of the horizontal...

78 FR 70211 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

.... ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing... assemblies of the inboard track of the left and right inboard flaps for cracking, and corrective actions if... Operations, M-30, West Building [[Page 70212

Performance-based workload assessment: Allocation strategy and added task sensitivity

NASA Technical Reports Server (NTRS)

Vidulich, Michael A.

1990-01-01

The preliminary results of a research program investigating the use of added tasks to evaluate mental workload are reviewed. The focus of the first studies was a reappraisal of the traditional secondary task logic that encouraged the use of low-priority instructions for the added task. It was believed that such low-priority tasks would encourage subjects to split their available resources among the two tasks. The primary task would be assigned all the resources it needed, and any remaining reserve capacity would be assigned to the secondary task. If the model were correct, this approach was expected to combine sensitivity to primary task difficulty with unintrusiveness to primary task performance. The first studies of the current project demonstrated that a high-priority added task, although intrusive, could be more sensitive than the traditional low-priority secondary task. These results suggested that a more appropriate model of the attentional effects associated with added task performance might be based on capacity switching, rather than the traditional optimal allocation model.

Frontiers in the pathogenesis of Alzheimer’s disease

PubMed Central

Sambamurti, Kumar; Jagannatha Rao, K. S.; Pappolla, Miguel A.

2009-01-01

Alzheimer’s disease (AD) is characterized by progressive dementia and brain deposits of the amyloid β protein (Aβ) as senile plaques and the microtubule-associated protein, Tau, as neurofibrillary tangles (NFT). The current treatment of AD is limited to drugs that attempt to correct deficits in the cholinergic pathway or glutamate toxicity. These drugs show some improvement over a short period of time but the disease ultimately requires treatment to prevent and stop the neurodegeneration that affects multiple pathways. The currently favored hypothesis is that Aβ aggregates to toxic forms that induce neurodegeneration. Drugs that reduce Aβ successfully treat transgenic mouse models of AD, but the most promising anti-Aβ vaccination approach did not successfully treat AD in a clinical trial. These studies suggest that AD pathogenesis is a complex phenomenon and requires a more broad-based approach to identify mechanisms of neurodegeneration. Multiple hypotheses have been proposed and the field is ready for a new generation of ideas to develop early diagnostic approaches and develop successful treatment plans. PMID:21416019

Rindler fluid with weak momentum relaxation

NASA Astrophysics Data System (ADS)

Khimphun, Sunly; Lee, Bum-Hoon; Park, Chanyong; Zhang, Yun-Long

2018-01-01

We realize the weak momentum relaxation in Rindler fluid, which lives on the time-like cutoff surface in an accelerating frame of flat spacetime. The translational invariance is broken by massless scalar fields with weak strength. Both of the Ward identity and the momentum relaxation rate of Rindler fluid are obtained, with higher order correction in terms of the strength of momentum relaxation. The Rindler fluid with momentum relaxation could also be approached through the near horizon limit of cutoff AdS fluid with momentum relaxation, which lives on a finite time-like cutoff surface in Anti-de Sitter(AdS) spacetime, and further could be connected with the holographic conformal fluid living on AdS boundary at infinity. Thus, in the holographic Wilson renormalization group flow of the fluid/gravity correspondence with momentum relaxation, the Rindler fluid can be considered as the Infrared Radiation(IR) fixed point, and the holographic conformal fluid plays the role of the ultraviolet(UV) fixed point.

Prosody impairment and associated affective and behavioral disturbances in Alzheimer's disease.

PubMed

Roberts, V J; Ingram, S M; Lamar, M; Green, R C

1996-12-01

We examined the ability to produce, repeat, and comprehend emotional prosody in 20 patients with Alzheimer's disease (AD) and in 11 elderly normal control subjects. In addition, caregivers of AD patients completed affective and behavioral measures with reference to the patient. Relative to control subjects, comprehension of emotional prosody was marginally impaired in mildly demented AD patients, whereas production, comprehension, and repetition of emotional prosody were significantly impaired in moderately demented AD patients. The moderately demented patients performed significantly poorer than the mildly demented patients on the production and repetition tasks. In contrast, there was no significance difference between the two groups on the prosody comprehension task. Additional analyses revealed an inverse relationship between the ability to correctly produce and repeat emotional prosody and the frequency of agitated behaviors and depressive symptomatology in moderately demented patients. This latter findings suggests that the inability to communicate emotional message is associated with disturbances in mood and behavior in AD patients. Implications for the management of disruptive behavior in agitated and aprosodic AD patients include the development of caregiver sensitivity to unexpressed emotion and caregiver assistance with emotional expression.

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

PubMed

Vieira, Marcelo N N; Lyra E Silva, Natalia M; Ferreira, Sergio T; De Felice, Fernanda G

2017-01-01

Despite significant advances in current understanding of mechanisms of pathogenesis in Alzheimer's disease (AD), attempts at drug development based on those discoveries have failed to translate into effective, disease-modifying therapies. AD is a complex and multifactorial disease comprising a range of aberrant cellular/molecular processes taking part in different cell types and brain regions. As a consequence, therapeutics for AD should be able to block or compensate multiple abnormal pathological events. Here, we examine recent evidence that inhibition of protein tyrosine phosphatase 1B (PTP1B) may represent a promising strategy to combat a variety of AD-related detrimental processes. Besides its well described role as a negative regulator of insulin and leptin signaling, PTB1B recently emerged as a modulator of various other processes in the central nervous system (CNS) that are also implicated in AD. These include signaling pathways germane to learning and memory, regulation of synapse dynamics, endoplasmic reticulum (ER) stress and microglia-mediated neuroinflammation. We propose that PTP1B inhibition may represent an attractive and yet unexplored therapeutic approach to correct aberrant signaling pathways linked to AD.

Code Properties from Holographic Geometries

NASA Astrophysics Data System (ADS)

Pastawski, Fernando; Preskill, John

2017-04-01

Almheiri, Dong, and Harlow [J. High Energy Phys. 04 (2015) 163., 10.1007/JHEP04(2015)163] proposed a highly illuminating connection between the AdS /CFT holographic correspondence and operator algebra quantum error correction (OAQEC). Here, we explore this connection further. We derive some general results about OAQEC, as well as results that apply specifically to quantum codes that admit a holographic interpretation. We introduce a new quantity called price, which characterizes the support of a protected logical system, and find constraints on the price and the distance for logical subalgebras of quantum codes. We show that holographic codes defined on bulk manifolds with asymptotically negative curvature exhibit uberholography, meaning that a bulk logical algebra can be supported on a boundary region with a fractal structure. We argue that, for holographic codes defined on bulk manifolds with asymptotically flat or positive curvature, the boundary physics must be highly nonlocal, an observation with potential implications for black holes and for quantum gravity in AdS space at distance scales that are small compared to the AdS curvature radius.

Head motion evaluation and correction for PET scans with 18F-FDG in the Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) multi-center study.

PubMed

Ikari, Yasuhiko; Nishio, Tomoyuki; Makishi, Yoko; Miya, Yukari; Ito, Kengo; Koeppe, Robert A; Senda, Michio

2012-08-01

Head motion during 30-min (six 5-min frames) brain PET scans starting 30 min post-injection of FDG was evaluated together with the effect of post hoc motion correction between frames in J-ADNI multicenter study carried out in 24 PET centers on a total of 172 subjects consisting of 81 normal subjects, 55 mild cognitive impairment (MCI) and 36 mild Alzheimer's disease (AD) patients. Based on the magnitude of the between-frame co-registration parameters, the scans were classified into six levels (A-F) of motion degree. The effect of motion and its correction was evaluated using between-frame variation of the regional FDG uptake values on ROIs placed over cerebral cortical areas. Although AD patients tended to present larger motion (motion level E or F in 22 % of the subjects) than MCI (3 %) and normal (4 %) subjects, unignorable motion was observed in a small number of subjects in the latter groups as well. The between-frame coefficient of variation (SD/mean) was 0.5 % in the frontal, 0.6 % in the parietal and 1.8 % in the posterior cingulate ROI for the scans of motion level 1. The respective values were 1.5, 1.4, and 3.6 % for the scans of motion level F, but reduced by the motion correction to 0.5, 0.4 and 0.8 %, respectively. The motion correction changed the ROI value for the posterior cingulate cortex by 11.6 % in the case of severest motion. Substantial head motion occurs in a fraction of subjects in a multicenter setup which includes PET centers lacking sufficient experience in imaging demented patients. A simple frame-by-frame co-registration technique that can be applied to any PET camera model is effective in correcting for motion and improving quantitative capability.

Memory Alteration Test to Detect Amnestic Mild Cognitive Impairment and Early Alzheimer's Dementia in Population with Low Educational Level.

PubMed

Custodio, Nilton; Lira, David; Herrera-Perez, Eder; Montesinos, Rosa; Castro-Suarez, Sheila; Cuenca-Alfaro, José; Valeriano-Lorenzo, Lucía

2017-01-01

Background/Aims : Short tests to early detection of the cognitive impairment are necessary in primary care setting, particularly in populations with low educational level. The aim of this study was to assess the performance of Memory Alteration Test (M@T) to discriminate controls, patients with amnestic Mild Cognitive Impairment (aMCI) and patients with early Alzheimer's Dementia (AD) in a sample of individuals with low level of education. Methods : Cross-sectional study to assess the performance of the M@T (study test), compared to the neuropsychological evaluation (gold standard test) scores in 247 elderly subjects with low education level from Lima-Peru. The cognitive evaluation included three sequential stages: (1) screening (to detect cases with cognitive impairment); (2) nosological diagnosis (to determinate specific disease); and (3) classification (to differentiate disease subtypes). The subjects with negative results for all stages were considered as cognitively normal (controls). The test performance was assessed by means of area under the receiver operating characteristic (ROC) curve. We calculated validity measures (sensitivity, specificity and correctly classified percentage), the internal consistency (Cronbach's alpha coefficient), and concurrent validity (Pearson's ratio coefficient between the M@T and Clinical Dementia Rating (CDR) scores). Results : The Cronbach's alpha coefficient was 0.79 and Pearson's ratio coefficient was 0.79 ( p < 0.01). The AUC of M@T to discriminate between early AD and aMCI was 99.60% (sensitivity = 100.00%, specificity = 97.53% and correctly classified = 98.41%) and to discriminate between aMCI and controls was 99.56% (sensitivity = 99.17%, specificity = 91.11%, and correctly classified = 96.99%). Conclusions : The M@T is a short test with a good performance to discriminate controls, aMCI and early AD in individuals with low level of education from urban settings.

The X-43 Fin Actuation System Problem - Reliability in Shades of Gray

NASA Technical Reports Server (NTRS)

Peebles, Curtis

2006-01-01

Following the loss of the first X-43 during launch, the mishap investigation board indicated the Fin Actuator System (FAS) needed to have a larger torque margin. To supply this added torque, a second actuator was added. The consequences of what seemed to be a simple modification would trouble the X-43 program. Because of the second actuator, a new computer board was required. This proved to be subject to electronic noise. This resulted in the actuator latch up in ground tests of the FAS for the second launch. Such a latch up would cause the Pegasus booster to fail, as the FAS was a single string system. The problem was corrected and the second flight was successful. The same modifications were added to the FAS for flight three. When the FAS underwent ground tests, it also latched up. The failure indicated that each computer board had a different tolerance to electronic noise. The problem with the FAS was corrected. Subsequently, another failure occurred, raising questions about the design, and the probability of failure for the X-43 Mach 10 flight. This was not simply a technical issue, but illuminated the difficulties facing both managers and engineers in assessing risk, design requirements, and probabilities in cutting edge aerospace projects.

Comparing cerebral perfusion in Alzheimer's disease and Parkinson's disease dementia: an ASL-MRI study.

PubMed

Le Heron, Campbell J; Wright, Sarah L; Melzer, Tracy R; Myall, Daniel J; MacAskill, Michael R; Livingston, Leslie; Keenan, Ross J; Watts, Richard; Dalrymple-Alford, John C; Anderson, Tim J

2014-06-01

Emerging evidence suggests that Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) share neurodegenerative mechanisms. We sought to directly compare cerebral perfusion in these two conditions using arterial spin labeling magnetic resonance imaging (ASL-MRI). In total, 17 AD, 20 PDD, and 37 matched healthy controls completed ASL and structural MRI, and comprehensive neuropsychological testing. Alzheimer's disease and PDD perfusion was analyzed by whole-brain voxel-based analysis (to assess absolute blood flow), a priori specified region of interest analysis, and principal component analysis (to generate a network differentiating the two groups). Corrections were made for cerebral atrophy, age, sex, education, and MRI scanner software version. Analysis of absolute blood flow showed no significant differences between AD and PDD. Comparing each group with controls revealed an overlapping, posterior pattern of hypoperfusion, including posterior cingulate gyrus, precuneus, and occipital regions. The perfusion network that differentiated AD and PDD groups identified relative differences in medial temporal lobes (AD

Network capability estimation. Vela network evaluation and automatic processing research. Technical report. [NETWORTH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snell, N.S.

1976-09-24

NETWORTH is a computer program which calculates the detection and location capability of seismic networks. A modified version of NETWORTH has been developed. This program has been used to evaluate the effect of station 'downtime', the signal amplitude variance, and the station detection threshold upon network detection capability. In this version all parameters may be changed separately for individual stations. The capability of using signal amplitude corrections has been added. The function of amplitude corrections is to remove possible bias in the magnitude estimate due to inhomogeneous signal attenuation. These corrections may be applied to individual stations, individual epicenters, ormore » individual station/epicenter combinations. An option has been added to calculate the effect of station 'downtime' upon network capability. This study indicates that, if capability loss due to detection errors can be minimized, then station detection threshold and station reliability will be the fundamental limits to network performance. A baseline network of thirteen stations has been performed. These stations are as follows: Alaskan Long Period Array, (ALPA); Ankara, (ANK); Chiang Mai, (CHG); Korean Seismic Research Station, (KSRS); Large Aperture Seismic Array, (LASA); Mashhad, (MSH); Mundaring, (MUN); Norwegian Seismic Array, (NORSAR); New Delhi, (NWDEL); Red Knife, Ontario, (RK-ON); Shillong, (SHL); Taipei, (TAP); and White Horse, Yukon, (WH-YK).« less

Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome

PubMed Central

Shaw, Jillian L.; Zhang, Shixing

2015-01-01

Aging individuals with Down syndrome (DS) have an increased risk of developing Alzheimer's disease (AD), a neurodegenerative disorder characterized by impaired memory. Memory problems in both DS and AD individuals usually develop slowly and progressively get worse with age, but the cause of this age-dependent memory impairment is not well understood. This study examines the functional interactions between Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in both DS and AD, in regulating memory. Using Drosophila as a model, we find that overexpression of nebula (fly homolog of DSCR1) initially protects against APP-induced memory defects by correcting calcineurin and cAMP signaling pathways but accelerates the rate of memory loss and exacerbates mitochondrial dysfunction in older animals. We report that transient upregulation of Nebula/DSCR1 or acute pharmacological inhibition of calcineurin in aged flies protected against APP-induced memory loss. Our data suggest that calcineurin dyshomeostasis underlies age-dependent memory impairments and further imply that chronic Nebula/DSCR1 upregulation may contribute to age-dependent memory impairments in AD in DS. SIGNIFICANCE STATEMENT Most Down syndrome (DS) individuals eventually develop Alzheimer's disease (AD)-like dementia, but mechanisms underlying this age-dependent memory impairment remain poorly understood. This study examines Nebula/Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in both DS and AD, in regulating memory. We uncover a previously unidentified role for Nebula/DSCR1 in modulating APP-induced memory defects during aging. We show that upregulation of Nebula/DSCR1, an inhibitor of calcineurin, rescues APP-induced memory defects in young flies but enhances memory loss of older flies. Excitingly, transient Nebula/DSCR1 overexpression or calcineurin inhibition in aged flies ameliorates APP-mediated memory problems. These results suggest that chronic Nebula/DSCR1 upregulation may contribute to age-dependent memory loss in DS and AD and points to correcting calcineurin signaling as a means to improve memory during aging. PMID:26269644

Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome.

PubMed

Shaw, Jillian L; Zhang, Shixing; Chang, Karen T

2015-08-12

Aging individuals with Down syndrome (DS) have an increased risk of developing Alzheimer's disease (AD), a neurodegenerative disorder characterized by impaired memory. Memory problems in both DS and AD individuals usually develop slowly and progressively get worse with age, but the cause of this age-dependent memory impairment is not well understood. This study examines the functional interactions between Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in both DS and AD, in regulating memory. Using Drosophila as a model, we find that overexpression of nebula (fly homolog of DSCR1) initially protects against APP-induced memory defects by correcting calcineurin and cAMP signaling pathways but accelerates the rate of memory loss and exacerbates mitochondrial dysfunction in older animals. We report that transient upregulation of Nebula/DSCR1 or acute pharmacological inhibition of calcineurin in aged flies protected against APP-induced memory loss. Our data suggest that calcineurin dyshomeostasis underlies age-dependent memory impairments and further imply that chronic Nebula/DSCR1 upregulation may contribute to age-dependent memory impairments in AD in DS. Most Down syndrome (DS) individuals eventually develop Alzheimer's disease (AD)-like dementia, but mechanisms underlying this age-dependent memory impairment remain poorly understood. This study examines Nebula/Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in both DS and AD, in regulating memory. We uncover a previously unidentified role for Nebula/DSCR1 in modulating APP-induced memory defects during aging. We show that upregulation of Nebula/DSCR1, an inhibitor of calcineurin, rescues APP-induced memory defects in young flies but enhances memory loss of older flies. Excitingly, transient Nebula/DSCR1 overexpression or calcineurin inhibition in aged flies ameliorates APP-mediated memory problems. These results suggest that chronic Nebula/DSCR1 upregulation may contribute to age-dependent memory loss in DS and AD and points to correcting calcineurin signaling as a means to improve memory during aging. Copyright © 2015 the authors 0270-6474/15/3511374-10$15.00/0.

HIV testing in correctional institutions: evaluating existing strategies, setting new standards.

PubMed

Basu, Sanjay; Smith-Rohrberg, Duncan; Hanck, Sarah; Altice, Frederick L

2005-01-01

Before introducing an HIV testing protocol into correctional facilities, the unique nature of these environments must be taken into account. We analyze three testing strategies that have been used in correctional settings--mandatory, voluntary, and routine "opt out" testing--and conclude that routine testing is most likely beneficial to inmates, the correctional system, and the outside community. The ethics of pre-release testing, and the issues surrounding segregation, confidentiality, and linking prisoners with community-based care, also play a role in determining how best to establish HIV testing strategies in correctional facilities. Testing must be performed in a manner that is not simply beneficial to public health, but also enhances the safety and health status of individual inmates. Longer-stay prison settings provide ample opportunities not just for testing but also for in-depth counseling, mental health and substance abuse treatment, and antiretroviral therapy. Jails present added complexities because of their shorter stay with respect to prisons, and testing, treatment, and counseling policies must be adapted to these settings.

Characterization of cross-section correction to charge exchange recombination spectroscopy rotation measurements using co- and counter-neutral-beam views.

PubMed

Solomon, W M; Burrell, K H; Feder, R; Nagy, A; Gohil, P; Groebner, R J

2008-10-01

Measurements of rotation using charge exchange recombination spectroscopy can be affected by the energy dependence of the charge exchange cross section. On DIII-D, the associated correction to the rotation can exceed 100 kms at high temperatures. In reactor-relevant low rotation conditions, the correction can be several times larger than the actual plasma rotation and therefore must be carefully validated. New chords have been added to the DIII-D CER diagnostic to view the counter-neutral-beam line. The addition of these views allows determination of the toroidal rotation without depending on detailed atomic physics calculations, while also allowing experimental characterization of the atomic physics. A database of rotation comparisons from the two views shows that the calculated cross-section correction can adequately describe the measurements, although there is a tendency for "overcorrection." In cases where accuracy better than about 15% is desired, relying on calculation of the cross-section correction may be insufficient.

Towards universal potentials for (H2)2 and isotopic variants: post-Born-Oppenheimer contributions.

PubMed

Diniz, Leonardo G; Mohallem, José R

2008-06-07

Adiabatic corrections are evaluated for the interaction of two hydrogen molecules (H(2))(2) and isotopic variants. Their contribution to the cluster formation amount up to 10% of the interaction energy. Added to the best ab initio Born-Oppenheimer isotropic potential, they correct especially its short range repulsive part. Calculations of second virial coefficients are improved in general, with an impressive agreement with experiments for gaseous D(2) in a large range of temperatures. The potentials are available in both analytical and numerical forms.

Comparison of two free-energy expressions and their implications in surface enrichment

NASA Astrophysics Data System (ADS)

Jerry, Rocco A.; Nauman, E. Bruce

1993-08-01

We compare two free-energy expressions, developed by Cohen and Muthukumar [J. Chem. Phys. 90, 5749 (1989)] and by Jerry and Nauman [J. Colloid Interface Sci. 154, 122 (1992)], in terms of their predictions concerning surface enrichment. We show that a term must be added to the former expression so that it may predict the correct dependence of the surface composition on the bulk. The latter expression does predict the correct dependence. We have also derived the quadratic surface-energy contribution from a finite (nonzero) range interaction model.

Thermodynamic studies of different black holes with modifications of entropy

NASA Astrophysics Data System (ADS)

Haldar, Amritendu; Biswas, Ritabrata

2018-02-01

In recent years, the thermodynamic properties of black holes are topics of interests. We investigate the thermodynamic properties like surface gravity and Hawking temperature on event horizon of regular black holes viz. Hayward Class and asymptotically AdS (Anti-de Sitter) black holes. We also analyze the thermodynamic volume and naive geometric volume of asymptotically AdS black holes and show that the entropy of these black holes is simply the ratio of the naive geometric volume to thermodynamic volume. We plot the different graphs and interpret them physically. We derive the `cosmic-Censorship-Inequality' for both type of black holes. Moreover, we calculate the thermal heat capacity of aforesaid black holes and study their stabilities in different regimes. Finally, we compute the logarithmic correction to the entropy for both the black holes considering the quantum fluctuations around the thermal equilibrium and study the corresponding thermodynamics.

75 FR 73983 - Assessments, Large Bank Pricing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-30

... 327 RIN 3064-AD66 Assessments, Large Bank Pricing AGENCY: Federal Deposit Insurance Corporation (FDIC... Pricing. This correction clarifies that the comment period for the Assessments, Large Bank Pricing ends January 3, 2011. FOR FURTHER INFORMATION CONTACT: Lisa Ryu, Chief, Large Bank Pricing Section, Division of...

78 FR 27001 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... one-time mid- frequency eddy current (MFEC) inspection, a low-frequency eddy current (LFEC) inspection... new AD instead requires repetitive external eddy current inspections for cracking of certain fuselage crown lap joints, and corrective actions if necessary; internal eddy current and detailed inspections...

Convergent genetic and expression data implicate immunity in Alzheimer's disease

PubMed Central

Jones, Lesley; Lambert, Jean-Charles; Wang, Li-San; Choi, Seung-Hoan; Harold, Denise; Vedernikov, Alexey; Escott-Price, Valentina; Stone, Timothy; Richards, Alexander; Bellenguez, Céline; Ibrahim-Verbaas, Carla A; Naj, Adam C; Sims, Rebecca; Gerrish, Amy; Jun, Gyungah; DeStefano, Anita L; Bis, Joshua C; Beecham, Gary W; Grenier-Boley, Benjamin; Russo, Giancarlo; Thornton-Wells, Tricia A; Jones, Nicola; Smith, Albert V; Chouraki, Vincent; Thomas, Charlene; Ikram, M Arfan; Zelenika, Diana; Vardarajan, Badri N; Kamatani, Yoichiro; Lin, Chiao-Feng; Schmidt, Helena; Kunkle, Brian; Dunstan, Melanie L; Ruiz, Agustin; Bihoreau, Marie-Thérèse; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Hanon, Olivier; Fitzpatrick, Annette L; Buxbaum, Joseph D; Campion, Dominique; Crane, Paul K; Becker, Tim; Gudnason, Vilmundur; Cruchaga, Carlos; Craig, David; Amin, Najaf; Berr, Claudine; Lopez, Oscar L; De Jager, Philip L; Deramecourt, Vincent; Johnston, Janet A; Evans, Denis; Lovestone, Simon; Letteneur, Luc; Kornhuber, Johanes; Tárraga, Lluís; Rubinsztein, David C; Eiriksdottir, Gudny; Sleegers, Kristel; Goate, Alison M; Fiévet, Nathalie; Huentelman, Matthew J; Gill, Michael; Emilsson, Valur; Brown, Kristelle; Kamboh, M Ilyas; Keller, Lina; Barberger-Gateau, Pascale; McGuinness, Bernadette; Larson, Eric B; Myers, Amanda J; Dufouil, Carole; Todd, Stephen; Wallon, David; Love, Seth; Kehoe, Pat; Rogaeva, Ekaterina; Gallacher, John; George-Hyslop, Peter St; Clarimon, Jordi; Lleὀ, Alberti; Bayer, Anthony; Tsuang, Debby W; Yu, Lei; Tsolaki, Magda; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petra; Collinge, John; Sorbi, Sandro; Garcia, Florentino Sanchez; Fox, Nick; Hardy, John; Naranjo, Maria Candida Deniz; Razquin, Cristina; Bosco, Paola; Clarke, Robert; Brayne, Carol; Galimberti, Daniela; Mancuso, Michelangelo; Moebus, Susanne; Mecocci, Patrizia; del Zompo, Maria; Maier, Wolfgang; Hampel, Harald; Pilotto, Alberto; Bullido, Maria; Panza, Francesco; Caffarra, Paolo; Nacmias, Benedetta; Gilbert, John R; Mayhaus, Manuel; Jessen, Frank; Dichgans, Martin; Lannfelt, Lars; Hakonarson, Hakon; Pichler, Sabrina; Carrasquillo, Minerva M; Ingelsson, Martin; Beekly, Duane; Alavarez, Victoria; Zou, Fanggeng; Valladares, Otto; Younkin, Steven G; Coto, Eliecer; Hamilton-Nelson, Kara L; Mateo, Ignacio; Owen, Michael J; Faber, Kelley M; Jonsson, Palmi V; Combarros, Onofre; O'Donovan, Michael C; Cantwell, Laura B; Soininen, Hilkka; Blacker, Deborah; Mead, Simon; Mosley, Thomas H; Bennett, David A; Harris, Tamara B; Fratiglioni, Laura; Holmes, Clive; de Bruijn, Renee FAG; Passmore, Peter; Montine, Thomas J; Bettens, Karolien; Rotter, Jerome I; Brice, Alexis; Morgan, Kevin; Foroud, Tatiana M; Kukull, Walter A; Hannequin, Didier; Powell, John F; Nalls, Michael A; Ritchie, Karen; Lunetta, Kathryn L; Kauwe, John SK; Boerwinkle, Eric; Riemenschneider, Matthias; Boada, Mercè; Hiltunen, Mikko; Martin, Eden R; Pastor, Pau; Schmidt, Reinhold; Rujescu, Dan; Dartigues, Jean-François; Mayeux, Richard; Tzourio, Christophe; Hofman, Albert; Nöthen, Markus M; Graff, Caroline; Psaty, Bruce M; Haines, Jonathan L; Lathrop, Mark; Pericak-Vance, Margaret A; Launer, Lenore J; Farrer, Lindsay A; van Duijn, Cornelia M; Van Broekhoven, Christine; Ramirez, Alfredo; Schellenberg, Gerard D; Seshadri, Sudha; Amouyel, Philippe; Holmans, Peter A

2015-01-01

Background Late–onset Alzheimer's disease (AD) is heritable with 20 genes showing genome wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease we extended these genetic data in a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (p = 3.27×10-12 after multiple testing correction for pathways), regulation of endocytosis (p = 1.31×10-11), cholesterol transport (p = 2.96 × 10-9) and proteasome-ubiquitin activity (p = 1.34×10-6). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected p 0.002 – 0.05). Conclusions The immune response, regulation of endocytosis, cholesterol transport and protein ubiquitination represent prime targets for AD therapeutics. PMID:25533204

Real time pipelined system for forming the sum of products in the processing of video data

NASA Technical Reports Server (NTRS)

Wilcox, Brian (Inventor)

1988-01-01

A 3-by-3 convolver utilizes 9 binary arithmetic units connected in cascade for multiplying 12-bit binary pixel values P sub i which are positive or two's complement binary numbers by 5-bit magnitide (plus sign) weights W sub i which may be positive or negative. The weights are stored in registers including the sign bits. For a negative weight, the one's complement of the pixel value to be multiplied is formed at each unit by a bank of 17 exclusive or gates G sub i under control of the sign of the corresponding weight W sub i, and a correction is made by adding the sum of the absolute values of all the negative weights for each 3-by-3 kernel. Since this correction value remains constant as long as the weights are constant, it can be precomputed and stored in a register as a value to be added to the product PW of the first arithmetic unit.

Convergent genetic and expression data implicate immunity in Alzheimer's disease.

PubMed

2015-06-01

Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10(-12) after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10(-11)), cholesterol transport (P = 2.96 × 10(-9)), and proteasome-ubiquitin activity (P = 1.34 × 10(-6)). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected P = .002-.05). The immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics. Copyright © 2015. Published by Elsevier Inc.

Individual Patient Diagnosis of AD and FTD via High-Dimensional Pattern Classification of MRI

PubMed Central

Davatzikos, C.; Resnick, S. M.; Wu, X.; Parmpi, P.; Clark, C. M.

2008-01-01

The purpose of this study is to determine the diagnostic accuracy of MRI-based high-dimensional pattern classification in differentiating between patients with Alzheimer’s Disease (AD), Frontotemporal Dementia (FTD), and healthy controls, on an individual patient basis. MRI scans of 37 patients with AD and 37 age-matched cognitively normal elderly individuals, as well as 12 patients with FTD and 12 age-matched cognitively normal elderly individuals, were analyzed using voxel-based analysis and high-dimensional pattern classification. Diagnostic sensitivity and specificity of spatial patterns of regional brain atrophy found to be characteristic of AD and FTD were determined via cross-validation and via split-sample methods. Complex spatial patterns of relatively reduced brain volumes were identified, including temporal, orbitofrontal, parietal and cingulate regions, which were predominantly characteristic of either AD or FTD. These patterns provided 100% diagnostic accuracy, when used to separate AD or FTD from healthy controls. The ability to correctly distinguish AD from FTD averaged 84.3%. All estimates of diagnostic accuracy were determined via cross-validation. In conclusion, AD- and FTD-specific patterns of brain atrophy can be detected with high accuracy using high-dimensional pattern classification of MRI scans obtained in a typical clinical setting. PMID:18474436

Correction factor for ablation algorithms used in corneal refractive surgery with gaussian-profile beams

NASA Astrophysics Data System (ADS)

Jimenez, Jose Ramón; González Anera, Rosario; Jiménez del Barco, Luis; Hita, Enrique; Pérez-Ocón, Francisco

2005-01-01

We provide a correction factor to be added in ablation algorithms when a Gaussian beam is used in photorefractive laser surgery. This factor, which quantifies the effect of pulse overlapping, depends on beam radius and spot size. We also deduce the expected post-surgical corneal radius and asphericity when considering this factor. Data on 141 eyes operated on LASIK (laser in situ keratomileusis) with a Gaussian profile show that the discrepancy between experimental and expected data on corneal power is significantly lower when using the correction factor. For an effective improvement of post-surgical visual quality, this factor should be applied in ablation algorithms that do not consider the effects of pulse overlapping with a Gaussian beam.

Robust scatter correction method for cone-beam CT using an interlacing-slit plate

NASA Astrophysics Data System (ADS)

Huang, Kui-Dong; Xu, Zhe; Zhang, Ding-Hua; Zhang, Hua; Shi, Wen-Long

2016-06-01

Cone-beam computed tomography (CBCT) has been widely used in medical imaging and industrial nondestructive testing, but the presence of scattered radiation will cause significant reduction of image quality. In this article, a robust scatter correction method for CBCT using an interlacing-slit plate (ISP) is carried out for convenient practice. Firstly, a Gaussian filtering method is proposed to compensate the missing data of the inner scatter image, and simultaneously avoid too-large values of calculated inner scatter and smooth the inner scatter field. Secondly, an interlacing-slit scan without detector gain correction is carried out to enhance the practicality and convenience of the scatter correction method. Finally, a denoising step for scatter-corrected projection images is added in the process flow to control the noise amplification The experimental results show that the improved method can not only make the scatter correction more robust and convenient, but also achieve a good quality of scatter-corrected slice images. Supported by National Science and Technology Major Project of the Ministry of Industry and Information Technology of China (2012ZX04007021), Aeronautical Science Fund of China (2014ZE53059), and Fundamental Research Funds for Central Universities of China (3102014KYJD022)

An algorithm developed in Matlab for the automatic selection of cut-off frequencies, in the correction of strong motion data

NASA Astrophysics Data System (ADS)

Sakkas, Georgios; Sakellariou, Nikolaos

2018-05-01

Strong motion recordings are the key in many earthquake engineering applications and are also fundamental for seismic design. The present study focuses on the automated correction of accelerograms, analog and digital. The main feature of the proposed algorithm is the automatic selection for the cut-off frequencies based on a minimum spectral value in a predefined frequency bandwidth, instead of the typical signal-to-noise approach. The algorithm follows the basic steps of the correction procedure (instrument correction, baseline correction and appropriate filtering). Besides the corrected time histories, Peak Ground Acceleration, Peak Ground Velocity, Peak Ground Displacement values and the corrected Fourier Spectra are also calculated as well as the response spectra. The algorithm is written in Matlab environment, is fast enough and can be used for batch processing or in real-time applications. In addition, the possibility to also perform a signal-to-noise ratio is added as well as to perform causal or acausal filtering. The algorithm has been tested in six significant earthquakes (Kozani-Grevena 1995, Aigio 1995, Athens 1999, Lefkada 2003 and Kefalonia 2014) of the Greek territory with analog and digital accelerograms.

Real-Time Phase Correction Based on FPGA in the Beam Position and Phase Measurement System

NASA Astrophysics Data System (ADS)

Gao, Xingshun; Zhao, Lei; Liu, Jinxin; Jiang, Zouyi; Hu, Xiaofang; Liu, Shubin; An, Qi

2016-12-01

A fully digital beam position and phase measurement (BPPM) system was designed for the linear accelerator (LINAC) in Accelerator Driven Sub-critical System (ADS) in China. Phase information is obtained from the summed signals from four pick-ups of the Beam Position Monitor (BPM). Considering that the delay variations of different analog circuit channels would introduce phase measurement errors, we propose a new method to tune the digital waveforms of four channels before summation and achieve real-time error correction. The process is based on the vector rotation method and implemented within one single Field Programmable Gate Array (FPGA) device. Tests were conducted to evaluate this correction method and the results indicate that a phase correction precision better than ± 0.3° over the dynamic range from -60 dBm to 0 dBm is achieved.

High-order corrections on the laser cooling limit in the Lamb-Dicke regime.

PubMed

Yi, Zhen; Gu, Wen-Ju

2017-01-23

We investigate corrections on the cooling limit of high-order Lamb-Dicke (LD) parameters in the double electromagnetically induced transparency (EIT) cooling scheme. Via utilizing quantum interferences, the single-phonon heating mechanism vanishes and the system evolves to a double dark state, from which we will obtain the mechanical occupation on the single-phonon excitation state. In addition, the further correction induced by two-phonon heating transitions is included to achieve a more accurate cooling limit. There exist two pathways of two-phonon heating transitions: direct two-phonon excitation from the dark state and further excitation from the single-phonon excited state. By adding up these two parts of correction, the obtained analytical predictions show a well consistence with numerical results. Moreover, we find that the two pathways can destructively interfere with each other, leading to the elimination of two-phonon heating transitions and achieving a lower cooling limit.

Identification of pre-clinical Alzheimer’s disease by a profile of pathogenic proteins in neurally-derived blood exosomes: a case-control study

PubMed Central

Fiandaca, Massimo S.; Kapogiannis, Dimitrios; Mapstone, Mark; Boxer, Adam; Eitan, Erez; Schwartz, Janice B.; Abner, Erin L.; Petersen, Ronald C.; Federoff, Howard J.; Miller, Bruce L.; Goetzl, Edward J.

2014-01-01

Background Proteins pathogenic in Alzheimer’s disease (AD) were extracted from neurally-derived blood exosomes and quantified to develop biomarkers for staging of sporadic AD. Methods Blood exosomes obtained at one time-point from patients with AD (n=57) or frontotemporal dementia (FTD) (n=16), and at two time-points from others (n=24) when cognitively normal and one-ten years later when diagnosed with AD were enriched for neural sources by immunoabsorption. AD-pathogenic exosomal proteins were extracted and quantified by ELISAs. Results Mean exosomal levels of total Tau, P-T181-tau, P-S396-tau and Aβ1-42 for AD and levels of P-T181-tau and Aβ1-42 for FTD were significantly higher than for case-controls. Stepwise discriminant modeling incorporated P-T181-tau, P-S396-tau and Aβ1-42 in AD, but only P-T181-tau in FTD. Classification of 96.4% of AD patients and 87.5% of FTD patients was correct. In 24 AD patients, exosomal levels of P-S396-tau, P-T181-tau and Aβ1-42 were significantly higher than for controls both one to ten years before and when diagnosed with AD. Conclusions Levels of P-S396-tau, P-T181-tau and Aβ1-42 in extracts of neurally-derived blood exosomes predict development of AD up to 10 years prior to clinical onset. PMID:25130657

Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function.

PubMed

Suzuki, Ayuko; Shinozaki, Jun; Yazawa, Shogo; Ueki, Yoshino; Matsukawa, Noriyuki; Shimohama, Shun; Nagamine, Takashi

2018-01-01

The mental rotation task is well-known for the assessment of visuospatial function; however, it has not been used for screening of dementia patients. The aim of this study was to create a simple screening test for patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) by focusing on non-amnestic symptoms. Age-matched healthy controls (age 75.3±6.8), patients with MCI (76.5±5.5), and AD (78.2±5.0) participated in this study. They carried out mental rotation tasks targeting geometric graphics or alphabetical characters with three rotating angles (0°, 90°, and 180°) and indicated the correct answer. Response accuracy and reaction time were recorded along with their eye movements using an eye tracker. To quantify their visual processing strategy, the run count ratio (RC ratio) was calculated by dividing the mean number of fixations in incorrect answers by that in correct answers. AD patients showed lower accuracy and longer reaction time than controls. They also showed a significantly greater number of fixation and smaller saccade amplitude than controls, while fixation duration did not differ significantly. The RC ratio was higher for AD, followed by MCI and control groups. By setting the cut-off value to 0.47 in the 180° rotating angle task, we could differentiate MCI patients from controls with a probability of 80.0%. We established a new screening system for dementia patients by evaluating visuospatial function. The RC ratio during a mental rotation task is useful for discriminating MCI patients from controls.

Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism.

PubMed

Mosconi, Lisa; Brys, Miroslaw; Switalski, Remigiusz; Mistur, Rachel; Glodzik, Lidia; Pirraglia, Elizabeth; Tsui, Wai; De Santi, Susan; de Leon, Mony J

2007-11-27

Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent with AD as compared with those without a family history and whether there are parent gender effects. Forty-nine 50- to 80-year-old normal subjects were examined who received clinical, neuropsychological, and 2-[(18)F]fluoro-2-deoxy-d-glucose-positron emission tomography examinations, including 16 subjects with a maternal (FHm) and eight with a paternal (FHp) family history of AD and 25 with no family history (FH(-)). FH groups were comparable for demographic and neuropsychological measures. As compared with both FH(-) and FHp groups, FHm subjects showed CMRglc reductions in the same regions as clinically affected AD patients, involving the posterior cingulate cortex/precuneus, parietotemporal and frontal cortices, and medial temporal lobes (P < 0.05, corrected for multiple comparisons). These effects remained significant after accounting for possible risk factors for AD, including age, gender, education, apolipoprotein E genotype, and subjective memory complaints. No CMRglc differences were found between FHp and FH(-) subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals.

Minimal area surfaces dual to Wilson loops and the Mathieu equation

DOE PAGES

Huang, Changyu; He, Yifei; Kruczenski, Martin

2016-08-11

The AdS/CFT correspondence relates Wilson loops in N=4 SYM to minimal area surfaces in AdS 5 × S 5 space. Recently, a new approach to study minimal area surfaces in AdS 3 c AdS 5 was discussed based on a Schroedinger equation with a periodic potential determined by the Schwarzian derivative of the shape of the Wilson loop. Here we use the Mathieu equation, a standard example of a periodic potential, to obtain a class of Wilson loops such that the area of the dual minimal area surface can be computed analytically in terms of eigenvalues of such equation. Asmore » opposed to previous examples, these minimal surfaces have an umbilical point (where the principal curvatures are equal) and are invariant under λ-deformations. In various limits they reduce to the single and multiple wound circular Wilson loop and to the regular light-like polygons studied by Alday and Maldacena. In this last limit, the periodic potential becomes a series of deep wells each related to a light-like segment. Small corrections are described by a tight-binding approximation. In the circular limit they are well approximated by an expansion developed by A. Dekel. In the particular case of no umbilical points they reduce to a previous solution proposed by J. Toledo. The construction works both in Euclidean and Minkowski signature of AdS 3.« less

Project SERAPHIM Report.

ERIC Educational Resources Information Center

Moore, John W.

1983-01-01

Lists and briefly describes computer programs recently added to those currently available from Project SERAPHIM. Program name, subject, hardware, author, supplier, and cost are provided in separate listings for Apple, PET, TRS-80 I or III, IBM, VIC-20, TERAK, and PDP-11 microcomputers. Includes corrections for two current Apple programs. (JN)

12 CFR 1267.1 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... means generally a financial contract the value of which is derived from the values of one or more referenced assets, rates, or indices of asset values, or credit-related events. Derivative contracts include... removing the definitions for “Investment grade” and “NRSRO” and adding in correct alphabetical order a...

27 CFR 30.64 - Table 4, showing the fractional part of a gallon per pound at each percent and each tenth percent...

Code of Federal Regulations, 2010 CFR

2010-04-01

... of the liquid and its apparent proof (hydrometer indication, corrected to 60 degrees Fahrenheit). The... of blended whisky containing added solids Temperature °F 75.0° Hydrometer reading 92.0° Apparent...

76 FR 72903 - Folding Metal Tables and Chairs From the People's Republic of China: Notice of Correction to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-868] Folding Metal Tables and... Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration... Astvatsatrian or Trisha Tran, AD/CVD Operations, Office 4, Import Administration, International Trade...

77 FR 65812 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

... (RAT) pump failure. This AD requires inspecting the RAT pump anti-stall valve for correct setting, re...: Vladimir Ulyanov, Aerospace Engineer, International Branch, ANM-116, Transport Airplane Directorate, FAA... anti-stall speed setting and leading to an inability of the hydraulic pump Part Number (P/N) 5909522 to...

78 FR 27318 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-10

... report of corrosion of the components of the main landing gear (MLG) retraction actuator found in service... pins. This proposed AD would require inspection of the MLG retraction actuator components; corrective actions if necessary; and, for certain retraction actuators, installation of a new jam nut. We are...

Summary of Comments on Test Methods Amendments Proposed in the Federal Register on August 27, 1997

EPA Pesticide Factsheets

(EPA) proposed amendments to 40 CFR Parts 60, 61, and 63 to reflect miscellaneous editorial changes and technical corrections throughout the parts in sections pertaining to source testing or monitoring of emissions and operations and added Performance Spec

78 FR 47549 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... Airworthiness Directives; The Boeing Company Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... to certain The Boeing Company Model 737-200, -200C, -300, and -400 series airplanes. AD 2000-06-13 R1..., adds inspections and related investigative and corrective actions, revises certain inspection types...

77 FR 66566 - Airworthiness Directives; Hawker Beechcraft Corporation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... elevator balance weights becoming loose or failing because the balance weight material was under strength... balance weights and replacement of defective elevator balance weights. We are proposing this AD to correct.... Discussion We received reports of elevator balance weights becoming loose or failing on Hawker Beechcraft...

21 CFR 150.110 - Fruit butter.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., canned, and/or dried (evaporated) mature fruits, with or without added water, and screening out skins... this section; (ii) multiply the percent so found by the weight of such fruit ingredient; (iii) divide... no correction is made for water-insoluble solids. Copies may be obtained from the AOAC INTERNATIONAL...

76 FR 18415 - Continuous Emission Monitoring

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 75 Continuous Emission Monitoring CFR Correction In... Sec. 75.11, paragraph (f) is added to read as follows: Sec. 75.11 Specific provisions for monitoring... wood, refuse, or other material in addition to oil or gas shall comply with the monitoring provisions...

Gauge/Gravity correspondence and black hole attractors in various dimensions

NASA Astrophysics Data System (ADS)

Li, Wei

This thesis investigates several topics on Gauge/Gravity correspondence and black hole attractors in various dimensions. The first chapter contains a brief review and summary of main results. Chapters 2 and 3 aim at a microscopic description of black objects in five dimensions. Chapter 2 studies higher-derivative corrections for 5D black rings and spinning black holes. It shows that certain R 2 terms found in Calabi-Yau compactifications of M-theory yield macroscopic corrections to the entropies that match the microscopic corrections. Chapter 3 constructs probe brane configurations that preserve half of the enhanced near-horizon supersymmetry of 5D spinning black holes, whose near-horizon geometry is squashed AdS2 x S 3. There are supersymmetric zero-brane probes stabilized by orbital angular momentum on S3 and one-brane probes with momentum and winding around a U(1)L x U(1)R torus in S3. Chapter 4 constructs and analyzes generic single-centered and multi-centered black hole attractor solutions in various four-dimensional models which, after Kaluza-Klein reduction, admit a description in terms of 3D gravity coupled to a sigma model whose target space is symmetric coset space. The solutions correspond to certain nilpotent generators of the coset algebra. The non-BPS black hole attractors are found to be drastically different from their BPS counterparts. Chapter 5 examines three-dimensional topologically massive gravity with negative cosmological constant in asymptotically AdS 3 spacetimes. It proves that the theory is unitary and stable only at a special value of Chern-Simons coupling, where the theory becomes chiral. This suggests the existence of a stable, consistent quantum gravity theory at the chiral point which is dual to a holomorphic boundary CFT 2. Finally, Chapter 6 studies the two-dimensional N = 1 critical string theory with a linear dilaton background. It constructs time-dependent boundary state solutions that correspond to D0-branes falling toward the Liouville wall. It also shows that there exist four types of stable, falling D0-branes (two branes and two anti-branes) in Type 0A projection and two unstable ones in Type 0B projection.

78 FR 51050 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

... report of cracking in a lower longeron in a nacelle. This AD requires repetitive inspections for cracking... detect and correct such cracking, which could result in degradation of the structural integrity of the... states: There has been one in-service report where a nacelle lower longeron was found to be cracked...

77 FR 28250 - Entity List Additions; Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... person who was added under the destination of Pakistan to clarify the text is the address of this person... follows: Pakistan (1) Jalaluddin Haqqani, a.k.a., the following seven aliases: --General Jalaluddin... Jalaluddin. --Miram Shah, Pakistan. United Arab Emirates (1) Al Maskah Used Car and Spare Parts, Maliha Road...

Quantum Mechanics for Beginning Physics Students

ERIC Educational Resources Information Center

Schneider, Mark B.

2010-01-01

The past two decades of attention to introductory physics education has emphasized enhanced development of conceptual understanding to accompany calculational ability. Given this, it is surprising that current texts continue to rely on the Bohr model to develop a flawed intuition, and introduce correct atomic physics on an ad hoc basis. For…

76 FR 72082 - Miscellaneous Administrative Changes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-22

... the 2008 administrative rule. Revise Table Formatting Error in 10 CFR Part 171 The table in paragraph (c) of Sec. 171.16 is missing a colon and a hard return that would separate the heading... subsequent list item, ``35 to 500 employees.'' The formatting errors are corrected, adding a colon after the...

77 FR 2669 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... methods and would inspect additional areas, and corrective actions if necessary. This proposed AD would... and 11.45, by any of the following methods: Federal eRulemaking Portal: Go to http://www.regulations...-mill cracking in the shear wrinkle areas Inspecting for vertical chem-mill cracking at specified...

77 FR 76228 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-27

.... We are issuing this AD to prevent loss of the hydraulic locking function during take-off and go... corrected, if occurring during take-off and go-around phases in combination with one engine inoperative... and go-around phases, which, in combination with malfunction of one engine, could result in reduced...

78 FR 60667 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... Airworthiness Directives; Airbus Airplanes AGENCY: Federal Aviation Administration (FAA), Department of... all Airbus Model A318, A319, A320, and A321 series airplanes. AD 2012- 26-51 required revising the...''), to correct an unsafe condition for the specified products. The MCAI states: Recently, an Airbus A330...

Author Correction: Ultrahard carbon film from epitaxial two-layer graphene.

PubMed

Gao, Yang; Cao, Tengfei; Cellini, Filippo; Berger, Claire; de Heer, Walter A; Tosatti, Erio; Riedo, Elisa; Bongiorno, Angelo

2018-05-21

In the version of this Article originally published, the second affiliation for Walter A. de Heer had not been included; it should be 'TICNN, Tianjin University, Tianjin, China'. This has now been added and the numbering of subsequent affiliations amended accordingly in all versions of the Article.

Finite Element Analysis of Free-Edge Delamination in Laminated Composite Specimens

DTIC Science & Technology

1991-06-18

for the degree of Doctor of Philosophy at the Ohio State University. Revision by H. R. Chu corrected some errors and added further studies on...Galerkin’s approach, in which interlaminar stresses and displacements of each layer satisfying geometrica ’ boundary conditions were represented as -series

77 FR 19567 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

... aeroplanes listed in the applicability section of this [EASA] AD. Static, fatigue and corrosion tests were... detect and correct cracked nuts on the fuselage which could result in reduced structural integrity of the... products. The MCAI states: During structural part assembly in Airbus production line, some nuts Part Number...

78 FR 56182 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... if certain motor-operated shutoff valve actuators for the fuel tanks are installed, and related...-operated shutoff valve actuators for the fuel tanks are installed, and related investigative and corrective... the different unsafe condition is applicable to all actuator locations required by AD 2008-06-03. We...

Hypnotic Enhancement of Cognitive-Behavioral Weight Loss Treatments--Another Meta-reanalysis.

ERIC Educational Resources Information Center

Kirsch, Irving

1996-01-01

In a meta-analysis of the effect of adding hypnosis to cognitive-behavioral treatments for weight reduction, additional data were obtained from authors of two previous studies, and computational inaccuracies in the previous meta-analyses were corrected. Discusses findings. Correlational analyses indicated that the benefits of hypnosis increased…

78 FR 52712 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-26

... prompted by reports of fractured rudder pedal tubes installed on the pilot-side rudder bar assembly. This... tubes, and replacement of affected pilot-side rudder bar assemblies if necessary. We are proposing this AD to detect and correct cracking of both pilot-side rudder pedal tubes, which could result in loss...

76 FR 22295 - National Poultry Improvement Plan and Auxiliary Provisions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-21

... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection 9 CFR Part 145 [Docket No. APHIS-2009-0031] RIN 0579-AD21 National Poultry Improvement Plan and Auxiliary Provisions Correction In rule document 2011-6539 appearing on pages 15791-15798 in the issue of Tuesday, March 22, 2011, make the...

76 FR 32332 - Office of Thrift Supervision Integration; Dodd-Frank Act Implementation; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-06

..., and 34 [Docket ID OCC-2011-0006] RIN 1557-AD41 Office of Thrift Supervision Integration; Dodd-Frank... Thrift Supervision Integration; Dodd- Frank Act Implementation.'' Inadvertently, an incorrect E-mail...) requesting comment on its notice of proposed rulemaking entitled ``Office of Thrift Supervision Integration...

Perspectives on a Torts Course.

ERIC Educational Resources Information Center

Bernstein, Anita

1993-01-01

One law professor has added interest to a torts course by asking students to select one of five perspectives (economics, corrective justice, feminism, libertarianism, and practicality) on the course content and study it throughout the course. On the final examination, each student must answer one essay question from that viewpoint. (MSE)

78 FR 52419 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-23

... trailing edge flap area that qualify as structural significant items (SSIs). This AD requires revising the... detect and correct fatigue cracking of the wing trailing edge structure, which could result in... within the wing trailing edge flap area that qualify as structural significant items (SSI). We are...

75 FR 76930 - Real-Time Public Reporting of Swap Transaction Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-10

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 43 RIN 3038-AD08 Real-Time Public Reporting of Swap Transaction Data Correction In proposed rule document 2010-29994 beginning on page 76140 in the...--Additional Real-Time Public Reporting Data Fields for Options, Swaptions and Swaps with Embedded Options...

76 FR 16697 - Passenger Weight and Inspected Vessel Stability Requirements; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... Mr. William Peters, U.S. Coast Guard, Office of Design and Engineering Standards, Naval Architecture... December 14, 2010 (75 FR 78064). That rule, among other things, added new definitions of ``Assumed average weight per person'', ``Constructed'', and ``Lightweight'' to 46 CFR 170.055. The definition of ``Length...

43 CFR 418.37 - Disincentives for lower efficiency.

Code of Federal Regulations, 2010 CFR

2010-10-01

... borrowed will be accounted for in the form of a deficit in Lahontan Reservoir storage. This deficit amount will be added to the actual Lahontan Reservoir storage quantity for the purpose of determining the... and other factors. This approach should allow the District to plan its operation to correct for any...

43 CFR 418.37 - Disincentives for lower efficiency.

Code of Federal Regulations, 2011 CFR

2011-10-01

... borrowed will be accounted for in the form of a deficit in Lahontan Reservoir storage. This deficit amount will be added to the actual Lahontan Reservoir storage quantity for the purpose of determining the... and other factors. This approach should allow the District to plan its operation to correct for any...

78 FR 32988 - Core Principles and Other Requirements for Designated Contract Markets; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 38 RIN 3038-AD09 Core Principles and Other... regarding Core Principles and Other Requirements for Designated Contract Markets by inserting a missing... regarding Core Principles and Other Requirements for Designated Contract Markets (77 FR 36612, June 19, 2012...

76 FR 53816 - Softwood Lumber Research, Promotion, Consumer Education and Industry Information Order; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-30

...-10-0015C; FR] RIN 0581-AD03 Softwood Lumber Research, Promotion, Consumer Education and Industry.... Pello, Marketing Specialist, Research and Promotion Division, Fruit and Vegetable Programs, AMS, USDA, P... Softwood Lumber Research, Promotion, Consumer Education and Industry Information Order (Order). The purpose...

78 FR 59801 - Airworthiness Directives; the Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

.... ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for certain The Boeing... chords between stringers S-22 and S-23, left and right sides; and corrective actions and preventive...-140, 1200 New Jersey Avenue SE., Washington, DC 20590. FOR FURTHER INFORMATION CONTACT: Alan Pohl...

Clinical Aspects of Foot Health in Individuals with Alzheimer's Disease.

PubMed

López-López, Daniel; Grela-Fariña, Marta; Losa-Iglesias, Marta Elena; Calvo-Lobo, César; Rodríguez-Sanz, David; Palomo-López, Patricia; Becerro-de-Bengoa-Vallejo, Ricardo

2018-02-07

Alzheimer's disease (AD) shows a marked presence of physiologic changes and the start or aggravation of underlying diseases such as physical frailty in diverse anatomical regions. It is believed to have a particularly harmful effect on the health of the foot. We examined the foot health status in older persons with AD, with a specific focus on the extent to which people with AD may be using inadequate footwear in old age. Seventy-three community-dwelling people with probable, mild to moderate AD aged 65-95 years were recruited from a center of excellence for AD. A single trained physician evaluated health status and foot conditions. Current shoe and foot length and width measurements were taken using a calibrated Brannock device. The results indicate that sixty-five participants (89.04%) suffered from feet problems. Also, only twenty-two subjects (30.14%) used the correct shoes in width and size related with the morphology of their feet. Fifty-one participants (69.86%) were using incorrect shoes in length or width. The present study revealed that peoples with AD had a high presence of foot health problems. Also, the use of inappropriate shoes revealed measurable differences of association between shoe size and the morphology of the foot.

A four-dimensional virtual hand brain-machine interface using active dimension selection.

PubMed

Rouse, Adam G

2016-06-01

Brain-machine interfaces (BMI) traditionally rely on a fixed, linear transformation from neural signals to an output state-space. In this study, the assumption that a BMI must control a fixed, orthogonal basis set was challenged and a novel active dimension selection (ADS) decoder was explored. ADS utilizes a two stage decoder by using neural signals to both (i) select an active dimension being controlled and (ii) control the velocity along the selected dimension. ADS decoding was tested in a monkey using 16 single units from premotor and primary motor cortex to successfully control a virtual hand avatar to move to eight different postures. Following training with the ADS decoder to control 2, 3, and then 4 dimensions, each emulating a grasp shape of the hand, performance reached 93% correct with a bit rate of 2.4 bits s(-1) for eight targets. Selection of eight targets using ADS control was more efficient, as measured by bit rate, than either full four-dimensional control or computer assisted one-dimensional control. ADS decoding allows a user to quickly and efficiently select different hand postures. This novel decoding scheme represents a potential method to reduce the complexity of high-dimension BMI control of the hand.

Classification of white wine aromas with an electronic nose.

PubMed

Lozano, J; Santos, J P; Horrillo, M C

2005-09-15

This paper reports the use of a tin dioxide multisensor array based electronic nose for recognition of 29 typical aromas in white wine. Headspace technique has been used to extract aroma of the wine. Multivariate analysis, including principal component analysis (PCA) as well as probabilistic neural networks (PNNs), has been used to identify the main aroma added to the wine. The results showed that in spite of the strong influence of ethanol and other majority compounds of wine, the system could discriminate correctly the aromatic compounds added to the wine with a minimum accuracy of 97.2%.

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.

PubMed

Chauhan, Ganesh; Adams, Hieab H H; Bis, Joshua C; Weinstein, Galit; Yu, Lei; Töglhofer, Anna Maria; Smith, Albert Vernon; van der Lee, Sven J; Gottesman, Rebecca F; Thomson, Russell; Wang, Jing; Yang, Qiong; Niessen, Wiro J; Lopez, Oscar L; Becker, James T; Phan, Thanh G; Beare, Richard J; Arfanakis, Konstantinos; Fleischman, Debra; Vernooij, Meike W; Mazoyer, Bernard; Schmidt, Helena; Srikanth, Velandai; Knopman, David S; Jack, Clifford R; Amouyel, Philippe; Hofman, Albert; DeCarli, Charles; Tzourio, Christophe; van Duijn, Cornelia M; Bennett, David A; Schmidt, Reinhold; Longstreth, William T; Mosley, Thomas H; Fornage, Myriam; Launer, Lenore J; Seshadri, Sudha; Ikram, M Arfan; Debette, Stephanie

2015-04-01

Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N = 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (p = 0.0006) and BIN1 with HV (p = 0.00089). A weighted AD genetic risk score was associated with smaller HV (beta ± SE = -0.047 ± 0.013, p = 0.00041), even after excluding the APOE locus (p = 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons. Copyright © 2015 Elsevier Inc. All rights reserved.

Frontal activity during a verbal emotional working memory task in patients with Alzheimer's disease: A functional near-infrared spectroscopy study.

PubMed

Ateş, Fatma Ebru; Cangöz, Banu; Özel Kızıl, Erguvan Tuğba; Baskak, Bora; Baran, Zeynel; Özgüven, Halise Devrimci

2017-03-30

Emotional working memory (EWM) is suggested as a working memory (WM) type, distinguished to process emotional stimuli, and may or may not be spared in Alzheimer's disease (AD). The aim was to compare patients with AD and healthy older adults (HC) on verbal EWM performance and accompanying prefrontal cortex activity. Twenty AD patients along with 20 HC individuals are required to complete an emotional one-back task in three conditions (neutral, positive and negative word lists). Prefrontal oxyhemoglobin (oxyHb) concentrations were measured simultaneously by a 24- channel functional near infrared spectroscopy device. Correct response rates were similar in two groups in all conditions. Reaction times were comparable in the EWM positive condition but longer in the AD group in EWMneutral and negative conditions. In the HC group, emotional words had no significant effect on WM. On the other hand, positive compared to neutral words led to greater activation in the left ventral prefrontal cortex (VPFC) in AD group. When compared to HCs, activity in the VPFC was significantly higher in AD patients during the positive condition. Positive words facilitated WM performance in participants with AD. Activity in VPFC may be the functional correlate of this phenomenon. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort.

PubMed

St John-Williams, Lisa; Blach, Colette; Toledo, Jon B; Rotroff, Daniel M; Kim, Sungeun; Klavins, Kristaps; Baillie, Rebecca; Han, Xianlin; Mahmoudiandehkordi, Siamak; Jack, John; Massaro, Tyler J; Lucas, Joseph E; Louie, Gregory; Motsinger-Reif, Alison A; Risacher, Shannon L; Saykin, Andrew J; Kastenmüller, Gabi; Arnold, Matthias; Koal, Therese; Moseley, M Arthur; Mangravite, Lara M; Peters, Mette A; Tenenbaum, Jessica D; Thompson, J Will; Kaddurah-Daouk, Rima

2017-10-17

Alzheimer's disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (ADNI) is creating a comprehensive biochemical database for AD. Using targeted and non- targeted metabolomics and lipidomics platforms we are mapping metabolic pathway and network failures across the trajectory of disease. In this report we present quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction. The dataset presented here is the first of eight metabolomics datasets being generated for broad biochemical investigation of the AD metabolome. We expect that these collective metabolomics datasets will provide valuable resources for researchers to identify novel molecular mechanisms contributing to AD pathogenesis and disease phenotypes.

Word recognition in Alzheimer's disease: Effects of semantic degeneration.

PubMed

Cuetos, Fernando; Arce, Noemí; Martínez, Carmen; Ellis, Andrew W

2017-03-01

Impairments of word recognition in Alzheimer's disease (AD) have been less widely investigated than impairments affecting word retrieval and production. In particular, we know little about what makes individual words easier or harder for patients with AD to recognize. We used a lexical selection task in which participants were shown sets of four items, each set consisting of one word and three non-words. The task was simply to point to the word on each trial. Forty patients with mild-to-moderate AD were significantly impaired on this task relative to matched controls who made very few errors. The number of patients with AD able to recognize each word correctly was predicted by the frequency, age of acquisition, and imageability of the words, but not by their length or number of orthographic neighbours. Patient Mini-Mental State Examination and phonological fluency scores also predicted the number of words recognized. We propose that progressive degradation of central semantic representations in AD differentially affects the ability to recognize low-imageability, low-frequency, late-acquired words, with the same factors affecting word recognition as affecting word retrieval. © 2015 The British Psychological Society.

Measuring the Perpetrators and Funders of Typosquatting

NASA Astrophysics Data System (ADS)

Moore, Tyler; Edelman, Benjamin

We describe a method for identifying "typosquatting", the intentional registration of misspellings of popular website addresses. We estimate that at least 938 000 typosquatting domains target the top 3 264 .com sites, and we crawl more than 285 000 of these domains to analyze their revenue sources. We find that 80% are supported by pay-per-click ads, often advertising the correctly spelled domain and its competitors. Another 20% include static redirection to other sites. We present an automated technique that uncovered 75 otherwise legitimate websites which benefited from direct links from thousands of misspellings of competing websites. Using regression analysis, we find that websites in categories with higher pay-per-click ad prices face more typosquatting registrations, indicating that ad platforms such as Google AdWords exacerbate typosquatting. However, our investigations also confirm the feasibility of significantly reducing typosquatting. We find that typosquatting is highly concentrated: Of typo domains showing Google ads, 63% use one of five advertising IDs, and some large name servers host typosquatting domains as much as four times as often as the web as a whole.

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

PubMed Central

St John-Williams, Lisa; Blach, Colette; Toledo, Jon B.; Rotroff, Daniel M.; Kim, Sungeun; Klavins, Kristaps; Baillie, Rebecca; Han, Xianlin; Mahmoudiandehkordi, Siamak; Jack, John; Massaro, Tyler J.; Lucas, Joseph E.; Louie, Gregory; Motsinger-Reif, Alison A.; Risacher, Shannon L.; Saykin, Andrew J.; Kastenmüller, Gabi; Arnold, Matthias; Koal, Therese; Moseley, M. Arthur; Mangravite, Lara M.; Peters, Mette A.; Tenenbaum, Jessica D.; Thompson, J. Will; Kaddurah-Daouk, Rima

2017-01-01

Alzheimer’s disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (ADNI) is creating a comprehensive biochemical database for AD. Using targeted and non- targeted metabolomics and lipidomics platforms we are mapping metabolic pathway and network failures across the trajectory of disease. In this report we present quantitative metabolomics data generated on serum from 199 control, 356 mild cognitive impairment and 175 AD subjects enrolled in ADNI1 using AbsoluteIDQ-p180 platform, along with the pipeline for data preprocessing and medication classification for confound correction. The dataset presented here is the first of eight metabolomics datasets being generated for broad biochemical investigation of the AD metabolome. We expect that these collective metabolomics datasets will provide valuable resources for researchers to identify novel molecular mechanisms contributing to AD pathogenesis and disease phenotypes. PMID:29039849

Genetic aspect of Alzheimer disease: Results of complex segregation analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sadonvick, A.D.; Lee, I.M.L.; Bailey-Wilson, J.E.

1994-09-01

The study was designed to evaluate the possibility that a single major locus will explain the segregation of Alzheimer disease (AD). The data were from the population-based AD Genetic Database and consisted of 402 consecutive, unrelated probands, diagnosed to have either `probable` or `autopsy confirmed` AD and their 2,245 first-degree relatives. In this analysis, a relative was considered affected with AD only when there were sufficient medical/autopsy data to support diagnosis of AD being the most likely cause of the dementia. Transmission probability models allowing for a genotype-dependent and logistically distributed age-of-onset were used. The program REGTL in the S.A.G.E.more » computer program package was used for a complex segregation analysis. The models included correction for single ascertainment. Regressive familial effects were not estimated. The data were analyzed to test for single major locus (SML), random transmission and no transmission (environmental) hypotheses. The results of the complex segregation analysis showed that (1) the SML was the best fit, and (2) the non-genetic models could be rejected.« less

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.

PubMed

Treutlein, Jens; Frank, Josef; Streit, Fabian; Reinbold, Céline S; Juraeva, Dilafruz; Degenhardt, Franziska; Rietschel, Liz; Witt, Stephanie H; Forstner, Andreas J; Ridinger, Monika; Strohmaier, Jana; Wodarz, Norbert; Dukal, Helene; Foo, Jerome C; Hoffmann, Per; Herms, Stefan; Heilmann-Heimbach, Stefanie; Soyka, Michael; Maier, Wolfgang; Gaebel, Wolfgang; Dahmen, Norbert; Scherbaum, Norbert; Müller-Myhsok, Bertram; Lucae, Susanne; Ising, Marcus; Stickel, Felix; Berg, Thomas; Roggenbuck, Ulla; Jöckel, Karl-Heinz; Scholz, Henrike; Zimmermann, Ulrich S; Buch, Stephan; Sommer, Wolfgang H; Spanagel, Rainer; Brors, Benedikt; Cichon, Sven; Mann, Karl; Kiefer, Falk; Hampe, Jochen; Rosendahl, Jonas; Nöthen, Markus M; Rietschel, Marcella

2017-07-17

The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach ( p uncorrected = 1.2 × 10 -6 ; p corrected = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed.

Elimination of Spurious Fractional Charges in Dissociating Molecules by Correcting the Shape of Approximate Kohn-Sham Potentials.

PubMed

Komsa, Darya N; Staroverov, Viktor N

2016-11-08

Standard density-functional approximations often incorrectly predict that heteronuclear diatomic molecules dissociate into fractionally charged atoms. We demonstrate that these spurious charges can be eliminated by adapting the shape-correction method for Kohn-Sham potentials that was originally introduced to improve Rydberg excitation energies [ Phys. Rev. Lett. 2012 , 108 , 253005 ]. Specifically, we show that if a suitably determined fraction of electron charge is added to or removed from a frontier Kohn-Sham orbital level, the approximate Kohn-Sham potential of a stretched molecule self-corrects by developing a semblance of step structure; if this potential is used to obtain the electron density of the neutral molecule, charge delocalization is blocked and spurious fractional charges disappear beyond a certain internuclear distance.

Thirty-eighth supplement to the American Ornithologists' Union Check-list of North American birds

USGS Publications Warehouse

Monroe, Burt L.; Banks, Richard C.; Fitzpatrick, John W.; Howell, Thomas R.; Johnson, Ned K.; Ouellet, Henri; Remsen, J.V.; Storer, Robert W.

1991-01-01

This fourth supplement after the 6th edition (1983) of the AOU "Check-list of North American Birds" consists of changes adopted by the Committee on Classification and Nomenclature between 1 March 1989 and 1 March 1991. The changes fall into eight categories: (1) five species (Ixobrychus sinensis, Porphyrula flavirostris, Sterna bergii, Streptopelia orientalis, and Ficedula narcissina) are added to the main list because of new distributional information; (2) six species (Pterodroma cervicalis, Ortalis wagleri, Lophornis brachylopha, Corvus sinaloae, Cinclocerthia gutturalis, and Loxops caeruleirostris) are added to the list because of the splitting of species previously in the list; (3) one extinct species (Dysmorodrepanis munroi) is added to the list because of re-identification of the unique type; (4) one scientific name (Speotyto cunicularia) is changed because of generic splitting; (5) one scientific name (Phalacrocorax brasilianus) is changed for nomenclature reasons, accompanied by a change in English name; (6) the spelling of one scientific name (Neocrex colombianus) is corrected; (7) to other English names are changed or corrected; and (8) one sequencing change is made. No new distributional information is included except as noted above (i.e. minor changes of distribution of distributional records within North America are not included). The twelve additions bring the number of species recognized as occurring within the Check-list area (main list) to 1957.

Fully Automated Atlas-Based Hippocampus Volumetry for Clinical Routine: Validation in Subjects with Mild Cognitive Impairment from the ADNI Cohort.

PubMed

Suppa, Per; Hampel, Harald; Spies, Lothar; Fiebach, Jochen B; Dubois, Bruno; Buchert, Ralph

2015-01-01

Hippocampus volumetry based on magnetic resonance imaging (MRI) has not yet been translated into everyday clinical diagnostic patient care, at least in part due to limited availability of appropriate software tools. In the present study, we evaluate a fully-automated and computationally efficient processing pipeline for atlas based hippocampal volumetry using freely available Statistical Parametric Mapping (SPM) software in 198 amnestic mild cognitive impairment (MCI) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI1). Subjects were grouped into MCI stable and MCI to probable Alzheimer's disease (AD) converters according to follow-up diagnoses at 12, 24, and 36 months. Hippocampal grey matter volume (HGMV) was obtained from baseline T1-weighted MRI and then corrected for total intracranial volume and age. Average processing time per subject was less than 4 minutes on a standard PC. The area under the receiver operator characteristic curve of the corrected HGMV for identification of MCI to probable AD converters within 12, 24, and 36 months was 0.78, 0.72, and 0.71, respectively. Thus, hippocampal volume computed with the fully-automated processing pipeline provides similar power for prediction of MCI to probable AD conversion as computationally more expensive methods. The whole processing pipeline has been made freely available as an SPM8 toolbox. It is easily set up and integrated into everyday clinical patient care.

Intelligent correction of laser beam propagation through turbulent media using adaptive optics

NASA Astrophysics Data System (ADS)

Ko, Jonathan; Wu, Chensheng; Davis, Christopher C.

2014-10-01

Adaptive optics methods have long been used by researchers in the astronomy field to retrieve correct images of celestial bodies. The approach is to use a deformable mirror combined with Shack-Hartmann sensors to correct the slightly distorted image when it propagates through the earth's atmospheric boundary layer, which can be viewed as adding relatively weak distortion in the last stage of propagation. However, the same strategy can't be easily applied to correct images propagating along a horizontal deep turbulence path. In fact, when turbulence levels becomes very strong (Cn 2>10-13 m-2/3), limited improvements have been made in correcting the heavily distorted images. We propose a method that reconstructs the light field that reaches the camera, which then provides information for controlling a deformable mirror. An intelligent algorithm is applied that provides significant improvement in correcting images. In our work, the light field reconstruction has been achieved with a newly designed modified plenoptic camera. As a result, by actively intervening with the coherent illumination beam, or by giving it various specific pre-distortions, a better (less turbulence affected) image can be obtained. This strategy can also be expanded to much more general applications such as correcting laser propagation through random media and can also help to improve designs in free space optical communication systems.

Wafer hotspot prevention using etch aware OPC correction

NASA Astrophysics Data System (ADS)

Hamouda, Ayman; Power, Dave; Salama, Mohamed; Chen, Ao

2016-03-01

As technology development advances into deep-sub-wavelength nodes, multiple patterning is becoming more essential to achieve the technology shrink requirements. Recently, Optical Proximity Correction (OPC) technology has proposed simultaneous correction of multiple mask-patterns to enable multiple patterning awareness during OPC correction. This is essential to prevent inter-layer hot-spots during the final pattern transfer. In state-of-art literature, multi-layer awareness is achieved using simultaneous resist-contour simulations to predict and correct for hot-spots during mask generation. However, this approach assumes a uniform etch shrink response for all patterns independent of their proximity, which isn't sufficient for the full prevention of inter-exposure hot-spot, for example different color space violations post etch or via coverage/enclosure post etch. In this paper, we explain the need to include the etch component during multiple patterning OPC. We also introduce a novel approach for Etch-aware simultaneous Multiple-patterning OPC, where we calibrate and verify a lumped model that includes the combined resist and etch responses. Adding this extra simulation condition during OPC is suitable for full chip processing from a computation intensity point of view. Also, using this model during OPC to predict and correct inter-exposures hot-spots is similar to previously proposed multiple-patterning OPC, yet our proposed approach more accurately corrects post-etch defects too.

An Efficient Correction Algorithm for Eliminating Image Misalignment Effects on Co-Phasing Measurement Accuracy for Segmented Active Optics Systems

PubMed Central

Yue, Dan; Xu, Shuyan; Nie, Haitao; Wang, Zongyang

2016-01-01

The misalignment between recorded in-focus and out-of-focus images using the Phase Diversity (PD) algorithm leads to a dramatic decline in wavefront detection accuracy and image recovery quality for segmented active optics systems. This paper demonstrates the theoretical relationship between the image misalignment and tip-tilt terms in Zernike polynomials of the wavefront phase for the first time, and an efficient two-step alignment correction algorithm is proposed to eliminate these misalignment effects. This algorithm processes a spatial 2-D cross-correlation of the misaligned images, revising the offset to 1 or 2 pixels and narrowing the search range for alignment. Then, it eliminates the need for subpixel fine alignment to achieve adaptive correction by adding additional tip-tilt terms to the Optical Transfer Function (OTF) of the out-of-focus channel. The experimental results demonstrate the feasibility and validity of the proposed correction algorithm to improve the measurement accuracy during the co-phasing of segmented mirrors. With this alignment correction, the reconstructed wavefront is more accurate, and the recovered image is of higher quality. PMID:26934045

All-electron quasiparticle self-consistent GW band structures for SrTiO 3 including lattice polarization corrections in different phases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhandari, Churna; van Schilfgaarde, Mark; Kotani, Takao

The electronic band structure of SrTiO3 is investigated in the all-electron quasiparticle self-consistent GW (QSGW) approximation. Unlike previous pseudopotential-based QSGW or single-shot G0W0 calculations, the gap is found to be significantly overestimated compared to experiment. After putting in a correction for the underestimate of the screening by the random phase approximation in terms of a 0.8Σ approach, the gap is still overestimated. The 0.8Σ approach is discussed and justified in terms of various recent literature results including electron-hole corrections. Adding a lattice polarization correction (LPC) in the q→0 limit for the screening of W, agreement with experiment is recovered. Themore » LPC is alternatively estimated using a polaron model. Here, we apply our approach to the cubic and tetragonal phases as well as a hypothetical layered postperovskite structure and find that the local density approximation (LDA) to GW gap correction is almost independent of structure.« less

All-electron quasiparticle self-consistent GW band structures for SrTiO 3 including lattice polarization corrections in different phases

DOE PAGES

Bhandari, Churna; van Schilfgaarde, Mark; Kotani, Takao; ...

2018-01-23

The electronic band structure of SrTiO3 is investigated in the all-electron quasiparticle self-consistent GW (QSGW) approximation. Unlike previous pseudopotential-based QSGW or single-shot G0W0 calculations, the gap is found to be significantly overestimated compared to experiment. After putting in a correction for the underestimate of the screening by the random phase approximation in terms of a 0.8Σ approach, the gap is still overestimated. The 0.8Σ approach is discussed and justified in terms of various recent literature results including electron-hole corrections. Adding a lattice polarization correction (LPC) in the q→0 limit for the screening of W, agreement with experiment is recovered. Themore » LPC is alternatively estimated using a polaron model. Here, we apply our approach to the cubic and tetragonal phases as well as a hypothetical layered postperovskite structure and find that the local density approximation (LDA) to GW gap correction is almost independent of structure.« less

SU-G-IeP1-06: Estimating Relative Tissue Density From Quantitative MR Images: A Novel Perspective for MRI-Only Heterogeneity Corrected Dose Calculation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soliman, A; Hashemi, M; Safigholi, H

Purpose: To explore the feasibility of extracting the relative density from quantitative MRI measurements as well as estimate a correlation between the extracted measures and CT Hounsfield units. Methods: MRI has the ability to separate water and fat signals, producing two separate images for each component. By performing appropriate corrections on the separated images, quantitative measurement of water and fat mass density can be estimated. This work aims to test this hypothesis on 1.5T.Peanut oil was used as fat-representative, while agar as water-representative. Gadolinium Chloride III and Sodium Chloride were added to the agar solution to adjust the relaxation timesmore » and the medium conductivity, respectively. Peanut oil was added to the agar solution with different percentages: 0%, 3%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100%. The phantom was scanned on 1.5T GE Optima 450W with the body coil using a multigradient echo sequences. Water/fat separation were performed while correcting for main field (B0) inhomogeneity and T{sub 2}* relaxation time. B1+ inhomogeneities were ignored. The phantom was subsequently scanned on a Philips Brilliance CT Big Bore. MR-corrected fat signal from all vials were normalized to 100% fat signal. CT Hounsfield values were then compared to those obtained from the normalized MR-corrected fat values as well as to the phantom for validation. Results: Good agreement were found between CT HU and the MR-extracted fat values (R{sup 2} = 0.98). CT HU also showed excellent agreement with the prepared fat fractions (R{sup 2}=0.99). Vials with 70%, 80%, and 90% fat percentages showed inhomogeneous distributions, however their results were included for completion. Conclusion: Quantitative MRI water/fat imaging can be potentially used to extract the relative tissue density. Further in-vivo validation are required.« less

Assessment of radar altimetry correction slopes for marine gravity recovery: A case study of Jason-1 GM data

NASA Astrophysics Data System (ADS)

Zhang, Shengjun; Li, Jiancheng; Jin, Taoyong; Che, Defu

2018-04-01

Marine gravity anomaly derived from satellite altimetry can be computed using either sea surface height or sea surface slope measurements. Here we consider the slope method and evaluate the errors in the slope of the corrections supplied with the Jason-1 geodetic mission data. The slope corrections are divided into three groups based on whether they are small, comparable, or large with respect to the 1 microradian error in the current sea surface slope models. (1) The small and thus negligible corrections include dry tropospheric correction, inverted barometer correction, solid earth tide and geocentric pole tide. (2) The moderately important corrections include wet tropospheric correction, dual-frequency ionospheric correction and sea state bias. The radiometer measurements are more preferred than model values in the geophysical data records for constraining wet tropospheric effect owing to the highly variable water-vapor structure in atmosphere. The items of dual-frequency ionospheric correction and sea state bias should better not be directly added to range observations for obtaining sea surface slopes since their inherent errors may cause abnormal sea surface slopes and along-track smoothing with uniform distribution weight in certain width is an effective strategy for avoiding introducing extra noises. The slopes calculated from radiometer wet tropospheric corrections, and along-track smoothed dual-frequency ionospheric corrections, sea state bias are generally within ±0.5 microradians and no larger than 1 microradians. (3) Ocean tide has the largest influence on obtaining sea surface slopes while most of ocean tide slopes distribute within ±3 microradians. Larger ocean tide slopes mostly occur over marginal and island-surrounding seas, and extra tidal models with better precision or with extending process (e.g. Got-e) are strongly recommended for updating corrections in geophysical data records.

Value of automatic patient motion detection and correction in myocardial perfusion imaging using a CZT-based SPECT camera.

PubMed

van Dijk, Joris D; van Dalen, Jorn A; Mouden, Mohamed; Ottervanger, Jan Paul; Knollema, Siert; Slump, Cornelis H; Jager, Pieter L

2018-04-01

Correction of motion has become feasible on cadmium-zinc-telluride (CZT)-based SPECT cameras during myocardial perfusion imaging (MPI). Our aim was to quantify the motion and to determine the value of automatic correction using commercially available software. We retrospectively included 83 consecutive patients who underwent stress-rest MPI CZT-SPECT and invasive fractional flow reserve (FFR) measurement. Eight-minute stress acquisitions were reformatted into 1.0- and 20-second bins to detect respiratory motion (RM) and patient motion (PM), respectively. RM and PM were quantified and scans were automatically corrected. Total perfusion deficit (TPD) and SPECT interpretation-normal, equivocal, or abnormal-were compared between the noncorrected and corrected scans. Scans with a changed SPECT interpretation were compared with FFR, the reference standard. Average RM was 2.5 ± 0.4 mm and maximal PM was 4.5 ± 1.3 mm. RM correction influenced the diagnostic outcomes in two patients based on TPD changes ≥7% and in nine patients based on changed visual interpretation. In only four of these patients, the changed SPECT interpretation corresponded with FFR measurements. Correction for PM did not influence the diagnostic outcomes. Respiratory motion and patient motion were small. Motion correction did not appear to improve the diagnostic outcome and, hence, the added value seems limited in MPI using CZT-based SPECT cameras.

[Evaluation of leptin levels in plasma and their reliance on other hormonal factors affecting tissue fat levels in people with various levels of endogenous cotisol].

PubMed

Robaczyk, Maciej G

2002-01-01

The discovery of leptin (LEP) shed new light on mechanisms regulating body fat mass (BFM). In this aspect, interactions between LEP and glucocorticoids at hypothalamic level may be of great importance. Factors that influence plasma LEP levels have not been fully recognized and available data on LEP levels are often inconsistent. The aim of this study was to evaluate absolute and BFM-corrected plasma LEP levels and their diurnal variation, as well as to assess the relationship between LEP levels, body fat distribution, and hormones influencing body fat in subjects with various levels of endogenous cortisol and different nutritional status. Group I was composed of 14 women aged 14-58 yrs, BMI of 23.9-37.1 kg/m2, with hypercortisolism due to ACTH-dependent and ACTH-independent Cushing's syndrome (CUS). 17 women with visceral obesity (OTY) and normal or disturbed carbohydrate metabolism, i.e. impaired glucose tolerance (IGT) and diabetes mellitus (DM), aged 24 do 50 yrs, BMI 30.0-46.1 kg/m2, were included in group II. Group III consisted of 14 women with Addison's disease (AD), aged 18 do 63 yrs, BMI 15.4-31.6 kg/m2. The control group IV (KON) included 17 healthy women with normal BMI. BMI, WHR, body composition, and body fat distribution (DEXA method) were assessed in all subjects. Basal plasma levels of LEP, beta-endorphin (B-EP), cortisol (F), insulin-like growth factor-1 (IGF-1) were measured with RIA test kits. Plasma adrenocorticotrophin (ACTH) levels, serum levels of insulin (IRI) and growth hormone (GH) were measured with IRMA test kits. Blood glucose (G) concentration was determined with an enzymatic method. Adiposity-corrected LEP levels were expressed as LEP/BFM and LEP/%BF indices. Fasting insulin resistance index (FIRI) was also calculated. Higher BFM and %BF values were found in the OTY group as compared with CUS KON and AD groups. BFM distribution did not differ in KON and AD groups whereas CUS subjects exhibited a higher accumulation of fat in the trunk when compared to OTY subjects. Absolute LEP levels were correlated with trunk BF in CUS patients whereas in KON and AD groups these levels were correlated only with limb fat. Absolute LEP levels in CUS and OTY groups were comparable, whereas LEP/BFM and LEP/%BF indices were higher in the CUS group (Table 1) reflecting upregulation of LEP levels (Figs. 1, 2). BFM-corrected LEP levels were comparable in groups with normal cortisolemia, i.e. in OTY and KON groups, whereas in the AD group both absolute and BFM-corrected LEP levels were lower than in controls. No correlation was found between plasma levels of F and LEP in CUS and AD groups. This correlation was negative in KON (Fig. 3) and positive in OTY groups (Fig. 4). Moreover, KON and AD groups demonstrated a negative correlation between plasma ACTH and LEP levels. CUS patients showed positive, BFM-independent correlations between LEP levels, FIRI and G values, and a positive, BFM-dependent correlation between IRI and LEP levels. OTY patients exhibited a BFM-dependent positive correlation between FIRI and LEP levels. In these and in AD patients, a positive, BFM-independent correlation between IRI and LEP levels was found. Moreover, a negative, BFM-dependent correlation between GH and LEP levels was found in OTY patients. In this group, B-EP levels were positively correlated with LEP/BFM and LEP/%BF indices (Fig. 5). A negative correlation between LEP levels, LEP/BFM and LEP/%BF indices was ascertained in the AD group. In CUS, OTY, and KON groups, but not in the AD group, a midnight increase in leptin levels was observed. In conclusion, upregulation of leptin levels in relation to body fat in Cushing's syndrome is independent of the source of hypercortisolism. Apparently, it results from insulin resistance and hyperglycaemia and contributes to coexisting metabolic abnormalities. In Addison's disease, downregulation of leptin may reflect an adaptation mechanism to cortisol deficiency and result from low insulin and extremely high adrenocorticotrophin levels. In women with normal cortisol levels, irrespectively of nutritional status; leptin levels reflect body fat content. In obese subjects, leptin levels may be influenced by cortisol levels, high levels of insulin, IGF-1, and beta-endorphin as well as low levels of growth hormone. Disturbed function of hypothalamic-pituitary-adrenal axis (CUS, AD) does not directly influence diurnal variation in plasma leptin levels. In Cushing's syndrome, visceral fat may be a predominant source of leptin, whereas in women with normal or low cortisol levels peripherally accumulated fat may determine leptin secretion.

Auto-Configuration Protocols in Mobile Ad Hoc Networks

PubMed Central

Villalba, Luis Javier García; Matesanz, Julián García; Orozco, Ana Lucila Sandoval; Díaz, José Duván Márquez

2011-01-01

The TCP/IP protocol allows the different nodes in a network to communicate by associating a different IP address to each node. In wired or wireless networks with infrastructure, we have a server or node acting as such which correctly assigns IP addresses, but in mobile ad hoc networks there is no such centralized entity capable of carrying out this function. Therefore, a protocol is needed to perform the network configuration automatically and in a dynamic way, which will use all nodes in the network (or part thereof) as if they were servers that manage IP addresses. This article reviews the major proposed auto-configuration protocols for mobile ad hoc networks, with particular emphasis on one of the most recent: D2HCP. This work also includes a comparison of auto-configuration protocols for mobile ad hoc networks by specifying the most relevant metrics, such as a guarantee of uniqueness, overhead, latency, dependency on the routing protocol and uniformity. PMID:22163814

Moduli stabilising in heterotic nearly Kähler compactifications

NASA Astrophysics Data System (ADS)

Klaput, Michael; Lukas, Andre; Matti, Cyril; Svanes, Eirik E.

2013-01-01

We study heterotic string compactifications on nearly Kähler homogeneous spaces, including the gauge field effects which arise at order α'. Using Abelian gauge fields, we are able to solve the Bianchi identity and supersymmetry conditions to this order. The four-dimensional external space-time consists of a domain wall solution with moduli fields varying along the transverse direction. We find that the inclusion of α' corrections improves the moduli stabilization features of this solution. In this case, one of the dilaton and the volume modulus asymptotes to a constant value away from the domain wall. It is further shown that the inclusion of non-perturbative effects can stabilize the remaining modulus and "lift" the domain wall to an AdS vacuum. The coset SU(3)/U(1)2 is used as an explicit example to demonstrate the validity of this AdS vacuum. Our results show that heterotic nearly Kähler compactifications can lead to maximally symmetric four-dimensional space-times at the non-perturbative level.

Spontaneous low frequency BOLD signal variations from resting-state fMRI are decreased in Alzheimer disease

PubMed Central

Manning, Kathryn Y.; Rajakumar, Nagalingam; Gómez, Francisco A.; Soddu, Andrea; Borrie, Michael J.

2017-01-01

Previous studies have demonstrated altered brain activity in Alzheimer's disease using task based functional MRI (fMRI), network based resting-state fMRI, and glucose metabolism from 18F fluorodeoxyglucose-PET (FDG-PET). Our goal was to define a novel indicator of neuronal activity based on a first-order textural feature of the resting state functional MRI (RS-fMRI) signal. Furthermore, we examined the association between this neuronal activity metric and glucose metabolism from 18F FDG-PET. We studied 15 normal elderly controls (NEC) and 15 probable Alzheimer disease (AD) subjects from the AD Neuroimaging Initiative. An independent component analysis was applied to the RS-fMRI, followed by template matching to identify neuronal components (NC). A regional brain activity measurement was constructed based on the variation of the RS-fMRI signal of these NC. The standardized glucose uptake values of several brain regions relative to the cerebellum (SUVR) were measured from partial volume corrected FDG-PET images. Comparing the AD and NEC groups, the mean brain activity metric was significantly lower in the accumbens, while the glucose SUVR was significantly lower in the amygdala and hippocampus. The RS-fMRI brain activity metric was positively correlated with cognitive measures and amyloid β1–42 cerebral spinal fluid levels; however, these did not remain significant following Bonferroni correction. There was a significant linear correlation between the brain activity metric and the glucose SUVR measurements. This proof of concept study demonstrates that this novel and easy to implement RS-fMRI brain activity metric can differentiate a group of healthy elderly controls from a group of people with AD. PMID:28582450

Spontaneous low frequency BOLD signal variations from resting-state fMRI are decreased in Alzheimer disease.

PubMed

Kazemifar, Samaneh; Manning, Kathryn Y; Rajakumar, Nagalingam; Gómez, Francisco A; Soddu, Andrea; Borrie, Michael J; Menon, Ravi S; Bartha, Robert

2017-01-01

Previous studies have demonstrated altered brain activity in Alzheimer's disease using task based functional MRI (fMRI), network based resting-state fMRI, and glucose metabolism from 18F fluorodeoxyglucose-PET (FDG-PET). Our goal was to define a novel indicator of neuronal activity based on a first-order textural feature of the resting state functional MRI (RS-fMRI) signal. Furthermore, we examined the association between this neuronal activity metric and glucose metabolism from 18F FDG-PET. We studied 15 normal elderly controls (NEC) and 15 probable Alzheimer disease (AD) subjects from the AD Neuroimaging Initiative. An independent component analysis was applied to the RS-fMRI, followed by template matching to identify neuronal components (NC). A regional brain activity measurement was constructed based on the variation of the RS-fMRI signal of these NC. The standardized glucose uptake values of several brain regions relative to the cerebellum (SUVR) were measured from partial volume corrected FDG-PET images. Comparing the AD and NEC groups, the mean brain activity metric was significantly lower in the accumbens, while the glucose SUVR was significantly lower in the amygdala and hippocampus. The RS-fMRI brain activity metric was positively correlated with cognitive measures and amyloid β1-42 cerebral spinal fluid levels; however, these did not remain significant following Bonferroni correction. There was a significant linear correlation between the brain activity metric and the glucose SUVR measurements. This proof of concept study demonstrates that this novel and easy to implement RS-fMRI brain activity metric can differentiate a group of healthy elderly controls from a group of people with AD.

Sequencing artifacts in the type A influenza databases and attempts to correct them.

PubMed

Suarez, David L; Chester, Nikki; Hatfield, Jason

2014-07-01

There are over 276 000 influenza gene sequences in public databases, with the quality of the sequences determined by the contributor. As part of a high school class project, influenza sequences with possible errors were identified in the public databases based on the size of the gene being longer than expected, with the hypothesis that these sequences would have an error. Students contacted sequence submitters alerting them of the possible sequence issue(s) and requested they the suspect sequence(s) be correct as appropriate. Type A influenza viruses were screened, and gene segments longer than the accepted size were identified for further analysis. Attention was placed on sequences with additional nucleotides upstream or downstream of the highly conserved non-coding ends of the viral segments. A total of 1081 sequences were identified that met this criterion. Three types of errors were commonly observed: non-influenza primer sequence wasn't removed from the sequence; PCR product was cloned and plasmid sequence was included in the sequence; and Taq polymerase added an adenine at the end of the PCR product. Internal insertions of nucleotide sequence were also commonly observed, but in many cases it was unclear if the sequence was correct or actually contained an error. A total of 215 sequences, or 22.8% of the suspect sequences, were corrected in the public databases in the first year of the student project. Unfortunately 138 additional sequences with possible errors were added to the databases in the second year. Additional awareness of the need for data integrity of sequences submitted to public databases is needed to fully reap the benefits of these large data sets. © 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

78 FR 52836 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

...) of America Code 2800, Aircraft Fuel System. (e) Unsafe Condition This AD was prompted by reports of... airplanes of total loss of boost pump pressure of the fuel feed system, followed by loss of fuel system... operational tests of the engine fuel suction feed of the fuel system, and corrective actions if necessary. We...

78 FR 39571 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

... 2800, Aircraft Fuel System. (e) Unsafe Condition This AD was prompted by reports of two in-service... system, followed by loss of fuel system suction feed capability on one engine, and in-flight shutdown of... and correct loss of the engine fuel suction feed capability of the fuel system, which, in the event of...

76 FR 37258 - Airworthiness Directives; Bombardier, Inc. Model DHC-8-400 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

... Aerospace has completed a system safety review of the aeroplanes fuel system against fuel tank safety... the fuel system are required to mitigate unsafe conditions that could result in potential ignition source within the fuel system. We are issuing this AD to require actions to correct the unsafe condition...

77 FR 33619 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

..., and doing related investigative and corrective actions if necessary. This new AD adds an [[Page 33620... or service door to open fully in the event of an emergency evacuation, which could impede exit from... necessary. That NPRM also proposed to add an airplane to the applicability and also remove certain other...

76 FR 82106 - Airworthiness Directives; Lockheed Martin Corporation/Lockheed Martin Aeronautics Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... results from a damage tolerance analysis conducted by the manufacturer indicating that fatigue cracking... cracking of the wing rear spar and upper surface zones, and repair if necessary. We are issuing this AD to detect and correct such fatigue cracking, which could result in cracking that grows large enough to...

78 FR 275 - Airworthiness Directives; REIMS Aviation S.A. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-03

... horizontal tail structure, which could cause the elevator pushrod to jam and could result in loss of control... corrected, could lead to failure of a pushrod and consequent jamming of the elevator controls, possibly resulting in loss of control of the aeroplane. For the reasons described above, this AD requires inspection...

76 FR 79145 - Floodplain Management and Protection of Wetlands

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

...] RIN 2501-AD51 Floodplain Management and Protection of Wetlands Correction In proposed rule document... action or an year floodplain outside of the amendment) \\1\\ Floodways Coastal high hazard outside coastal... existing structure; (2) is designed for a Coastal High Hazard Area under Sec. 55.1(c)(3); and (3) is...

78 FR 54380 - Airworthiness Directives; Eurocopter France Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... they are misaligned. This AD is prompted by the discovery of a loose nut on the tail rotor control stop... nut or a misaligned stop screw, which, if not corrected, could limit yaw authority, and consequently... adjusting the screws if they are misaligned. The proposed requirements were intended to detect a loose nut...

77 FR 40307 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

..., -400D, and -400F series airplanes. That NPRM proposed to require repetitive operational tests of the... operational tests and corrective actions if necessary. We are proposing this supplemental NPRM to detect and... received by the closing date and may amend this proposed AD because of those comments. We will post all...

The Voice of Holland: Allograph Production in Written Dutch Past Tense Inflection

ERIC Educational Resources Information Center

de Bree, Elise; van der Ven, Sanne; van der Maas, Han

2017-01-01

According to the Integration of Multiple Patterns hypothesis (IMP; Treiman & Kessler, 2014), the spelling difficulty of a word is affected by the number of cues converging on the correct answer. We tested this hypothesis in children's regular past tense formation in Dutch. Past tenses are formed by adding either-"de"…

78 FR 11092 - Safety and Health Regulations for Construction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... LABOR DEPARTMENT Occupational Safety and Health Administration 29 CFR Part 1926 Safety and Health Regulations for Construction CFR Correction In Title 29 of the Code of Federal Regulations, Part 1926, revised as of July 1, 2012, on page 225, in Sec. 1926.152, paragraph (c)(16) is added to read as follows: Sec...

77 FR 44437 - Airworthiness Directives; Embraer S.A. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... inspection to determine if a certain part number is installed on the MLG retraction actuator; if necessary... the MLG retraction actuator; and corrective actions if necessary. We are issuing this AD to detect and... occurrence of damage on the rod end of the Main Landing Gear (MLG) retraction actuator. The ANAC [Ag[ecirc...

78 FR 59304 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... ducting with smoke and fire. Incorrectly installed metal clamps, if not corrected, could cause wire bundle... with smoke and fire caused by metal clamps installed on certain hoses. We are issuing this AD to... chaffing, arcing, and burning damage to the control cabin overhead wiring and ducting with smoke and fire...

75 FR 17882 - Airworthiness Directives; The Boeing Company Model 737-300, -400, and -500 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... installed, repetitive inspections for corrosion and indications of corrosion on affected carriage spindles... eliminate the need for the repetitive inspections. The proposed AD results from reports of corrosion found... to detect and correct corrosion of the carriage spindle, which could result in fracture. Fracture of...

78 FR 11972 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... cracks in the skin and surrounding structure under the number 3 very high frequency (VHF) antenna on the.... This AD requires inspecting for cracking and corrosion under the number 3 VHF antenna, and corrective... cracks and corrosion of the skin and surrounding structure under the number 3 VHF antenna, which could...

75 FR 12670 - Airworthiness Directives; The Boeing Company Model 767 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

... joints, the skin at certain external approved repairs, the skin around external features such as antennas... antennas, and at locations where external decals had been cut. We are issuing this AD to detect and correct... skin at certain external approved repairs, the skin around external features such as antennas, and the...

75 FR 13009 - Procedures for Transportation Workplace Drug and Alcohol Testing Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... DEPARTMENT OF TRANSPORTATION Office of the Secretary 49 CFR Part 40 [Docket DOT-OST-2008-0088] RIN OST 2105-AD84 Procedures for Transportation Workplace Drug and Alcohol Testing Programs Correction In rule document 2010-3731 beginning on page 8528 in the issue of Thursday, February 25, 2010, make the...

Correctional Education as Democratic Citizenship Education

ERIC Educational Resources Information Center

Cantrell, Dustin

2013-01-01

Many educators view the process of education as transformative. This transformation is important in all classrooms, but it takes on added importance in prison classrooms. The education that inmates receive in prison can mean the difference between the doorway of freedom with a productive future and the revolving door of recidivism. For many prison…

Correctional Education as Democratic Citizenship Education

ERIC Educational Resources Information Center

Cantrell, Dustin

2012-01-01

Many educators view the process of education as transformative. This transformation is important in all classrooms, but it takes on added importance in prison classrooms. The education that inmates receive in prison can mean the difference between the doorway of freedom with a productive future and the revolving door of recidivism. For many prison…

January 2018 Corrigendum.

PubMed

2018-01-01

Corrections to an article published in the March 2013 issue of JOSPT: Xergia SA, Pappas E, Zampeli F, Georgiou S, Georgoulis AD. Asymmetries in functional hop tests, lower extremity kinematics, and isokinetic strength persist 6 to 9 months following anterior cruciate ligament reconstruction. J Orthop Sports Phys Ther 2018;48(1):52. doi:10.2519/jospt.2018.48.1.52.

75 FR 33162 - Airworthiness Directives; Microturbo Saphir 20 Model 095 Auxiliary Power Units (APUs)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... information (MCAI) issued by the European Aviation Safety Agency (EASA) to identify and correct an unsafe... States Code specifies the FAA's authority to issue rules on aviation safety. Subtitle I, section 106... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety...

78 FR 43761 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

... free-play check for excessive free-play of the shaft swaged bearing installed in the tailstock end of each elevator power control unit (PCU), and replacing any PCU on which the bearing exceeds allowable... condition. We are issuing this AD to detect and correct excessive free-play of the swaged bearings, which...

78 FR 42895 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... for cracking of the pressure floor of both main wheel wells, and related investigative and corrective actions if necessary; and would require modifying the pressure floor of both main wheel wells. We are proposing this AD to prevent fatigue cracking in the pressure floor of the main wheel wells, which could...

78 FR 60656 - Airworthiness Directives; Sikorsky Aircraft Corporation Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... firewall center fire extinguisher discharge tube (No. 1 engine tube) and inspecting the outboard discharge tube to determine if it is correctly positioned. This AD was prompted by the discovery that the No. 1 engine tube installed on the helicopters is too long to ensure that a fire could be effectively...

38 CFR 4.26 - Bilateral factor.

Code of Federal Regulations, 2010 CFR

2010-07-01

... specified type of impairment. (b) The correct procedure when applying the bilateral factor to disabilities... disabilities of the right and left sides will be combined as usual, and 10 percent of this value will be added... treated as 1 disability for the purpose of arranging in order of severity and for all further combinations...

76 FR 79054 - The Commerce Control List

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Part 774 The Commerce Control List CFR Correction 0 In Title 15 of the Code of Federal Regulations, Parts 300 to 799, revised as of... entry in the table under Reasons for control for NS Column 1 and adding an entry following the remaining...

77 FR 48060 - Real-Time Public Reporting of Swap Transaction Data; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... COMMODITY FUTURES TRADING COMMISSION 17 CFR Part 43 RIN 3038-AD08 Real-Time Public Reporting of...'') published the Real-Time Public Reporting of Swap Transaction Data (``Real-Time Public Reporting'') rule and.... Background The Commission published the final rule entitled Real-Time Public Reporting of Swap Transaction...

77 FR 36222 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-18

... of an inboard main landing gear (MLG) door assembly departure due to premature fatigue cracking in... terminate the repetitive inspections. We are proposing this AD to detect and correct fatigue cracking in the... Delivery: Deliver to Mail address above between 9 a.m. and 5 p.m., Monday through Friday, except Federal...

78 FR 33012 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

... to detect and correct fatigue cracks in the fuselage skin that can propagate and grow, and result in... 5 p.m., Monday through Friday, except Federal holidays. For service information identified in this... between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. The AD docket contains this...

76 FR 81360 - Cooperative Inspection Programs: Interstate Shipment of Meat and Poultry Products; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

.... FSIS-2008-0039] RIN 0583-AD37 Cooperative Inspection Programs: Interstate Shipment of Meat and Poultry... to ship meat and poultry products in interstate commerce. The final rule was published in the Federal... the Federal Register, the final rule, ``Cooperative Inspection Programs; Interstate Shipment of Meat...

77 FR 33125 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... along the wing leading edge and the inboard end rib of the wing leading edge due to insufficient clearance. This proposed AD would require inspecting the wire harness along the leading edge for chafing... to detect and correct chafing damage to the wire harness along the wing leading edge which, if not...

75 FR 11433 - Airworthiness Directives; Hawker Beechcraft Corporation Model G58 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... brake reservoir tubing and the heater fuel pump wiring for minimum clearance and installing acceptable... of a power wire shorting out on the brake reservoir tube. We are issuing this AD to detect and correct inadequate clearance of the brake reservoir tubing and the heater fuel pump wiring, which could...

A Compilation of Laws Pertaining to Indians. State of Maine, July 1976.

ERIC Educational Resources Information Center

Maine State Dept. of Indian Affairs, Augusta.

Compiled from the Maine Revised Statutes of 1964, the Constitution of Maine, and the current Resolves and Private and Special Laws, this document constitutes an update to a previous publication (January 1974), correcting errors and adding amendments through 1976. This compilation of laws pertaining to American Indians includes statutes on the…

77 FR 12179 - Airworthiness Directives; Mooney Aviation Company, Inc. (Mooney) Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... inspecting the tail pitch trim assembly for correct positioning and proper attachment and inspecting the Huck... M20TN airplane regarding failure of the tail pitch trim assembly, which could result in loss of control...: Discussion On February 10, 2012, we issued Emergency AD 2012-03-52, which requires inspecting the trim...

77 FR 24643 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... airplanes. This proposed AD was prompted by a report of in-flight fracture of the right windshield (window 1..., followed by the fracture of the inner pane of the first officer's windshield (right window 1). This... (J5 terminal) at the left and right flight deck window 1 windshield, and corrective actions if...

77 FR 60073 - Airworthiness Directives; Saab AB, Saab Aerosystems Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-02

...; and 4. Will not have a significant economic impact, positive or negative, on a substantial number of... delegated agent). (i) Reporting Submit a report of the findings (both positive and negative) of the... AD to detect and correct any chafing on the bottom panel of the center cabin, which could affect the...

Explanation of Ambiguous Advertisements: A Developmental Study with Children and Adolescents.

ERIC Educational Resources Information Center

Nippold, Marilyn A.; And Others

1988-01-01

Forty students aged 9-18 were asked to explain the meanings of lexically ambiguous advertisements from magazines, newspapers, and brochures. Older subjects explained the meanings correctly more frequently than younger subjects. The psychological meanings of the ads were found to be more difficult to explain than the physical meanings. (Author/JDD)

76 FR 2279 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170 and ERJ...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-13

... de Aeronautica S.A. (EMBRAER) Model ERJ 170 and ERJ 190 Airplanes AGENCY: Federal Aviation... airworthiness information (MCAI) originated by an aviation authority of another country to identify and correct...., Monday through Friday, except Federal holidays. For service information identified in this proposed AD...

78 FR 33197 - Airworthiness Directives; Iniziative Industriali Italiane S.p.A. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-04

... plane hinge assembly. We are issuing this AD to require actions to address the unsafe condition on these... plane hinge assembly have been reported. This condition, if not detected and corrected, could lead to... bearing and the horizontal tail/elevator plane hinge assembly to detect any crack, signs of corrosion or...

77 FR 43547 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-25

...). SUMMARY: We propose to adopt a new airworthiness directive (AD) for certain The Boeing Company Model 737... stringers S-22 and S-23, left and right sides; and corrective actions and preventive modification if... Operations, M-30, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590...

77 FR 65805 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

.... ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for all The Boeing... current high frequency (ETHF) inspections for cracking on the aft side of the left and right wing rear... and correct cracking of the left and right rear spar lower caps, which could result in fuel leaks and...

76 FR 37247 - Airworthiness Directives; Learjet Inc. Model 45 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

... the left engine accessory compartment, and corrective actions if necessary. This new AD also requires...) Replace the left engine fuel and hydraulic tubing and install a tubing support channel using new parts. (2... other damage of the case drain tube from the hydraulic pump case installed on the left-hand engine, and...

Optimal Designs for Performance Assessments: The Subject Factor.

ERIC Educational Resources Information Center

Parkes, Jay

Much speculation abounds concerning how expensive performance assessments are or are going to be. Recent projections indicate that, in order to achieve an acceptably high generalizability coefficient, many additional tasks may need to be added, which will enlarge costs. Such projections are, to some degree, correct, and to some degree simplistic.…

76 FR 58416 - Airworthiness Directives; Lockheed Martin Corporation/Lockheed Martin Aeronautics Company Model L...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-21

... specifies a bolt hole eddy current inspection to verify the cracking. The corrective actions for cracking... specified in paragraph (k) of this AD, do eddy current non-destructive inspections (NDI) and detailed... secondary eddy current inspection to detect cracking of fastener holes with suspected crack indications; in...

76 FR 13985 - Gulf Spill Restoration Planning; Public Scoping Meetings for the Programmatic Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-15

... Deepwater Horizon Oil Spill; Correction AGENCY: National Marine Fisheries Service (NMFS), National Oceanic... Horizon Oil Spill. There is a date change for the meeting in Washington, DC. DATES: The public scoping....us . To be added to the Oil Spill PEIS mailing list, please visit: http://www.gulfspillrestoration...

The clinical diagnosis and misdiagnosis of senile dementia of Lewy body type (SDLT).

PubMed

McKeith, I G; Fairbairn, A F; Perry, R H; Thompson, P

1994-09-01

Current clinical classifications do not contain specific diagnostic categories for patients with senile dementia of the Lewy body type (SDLT), recently proposed as the second commonest neuropathological cause of dementia in the elderly. This study determines how existing clinical diagnosis systems label SDLT patients and suggests how such patients may be identified. A range of clinical diagnostic criteria for dementia were applied to case notes of autopsy-confirmed SDLT (n = 20), dementia of Alzheimer type (DAT; n = 21) and multi-infarct dementia (MID; n = 9) patients who had received psychogeriatric assessment. The predictive validity of each set of clinical criteria was calculated against the external criterion of neuropathological diagnosis. Many SDLT patients erroneously met criteria for MID (35% with Hachinski scores > or = 7) or for DAT (15% by NINCDS 'probable AD', 35% by DSM-III-R DAT and 50% by NINCDS 'possible AD'). Up to 85% of SDLT cases could be correctly identified using recently published specific criteria. SDLT usually has a discernible clinical syndrome and existing clinical classifications may need revision to diagnose correctly such patients.

Autonomous power expert system advanced development

NASA Technical Reports Server (NTRS)

Quinn, Todd M.; Walters, Jerry L.

1991-01-01

The autonomous power expert (APEX) system is being developed at Lewis Research Center to function as a fault diagnosis advisor for a space power distribution test bed. APEX is a rule-based system capable of detecting faults and isolating the probable causes. APEX also has a justification facility to provide natural language explanations about conclusions reached during fault isolation. To help maintain the health of the power distribution system, additional capabilities were added to APEX. These capabilities allow detection and isolation of incipient faults and enable the expert system to recommend actions/procedure to correct the suspected fault conditions. New capabilities for incipient fault detection consist of storage and analysis of historical data and new user interface displays. After the cause of a fault is determined, appropriate recommended actions are selected by rule-based inferencing which provides corrective/extended test procedures. Color graphics displays and improved mouse-selectable menus were also added to provide a friendlier user interface. A discussion of APEX in general and a more detailed description of the incipient detection, recommended actions, and user interface developments during the last year are presented.

Stroop effects in Alzheimer's disease: selective attention speed of processing, or color-naming? A meta-analysis.

PubMed

Ben-David, Boaz M; Tewari, Anita; Shakuf, Vered; Van Lieshout, Pascal H H M

2014-01-01

Selective attention, an essential part of daily activity, is often impaired in people with Alzheimer's disease (AD). Usually, it is measured by the color-word Stroop test. However, there is no universal agreement whether performance on the Stroop task changes significantly in AD patients; or if so, whether an increase in Stroop effects reflects a decrease in selective attention, a slowing in generalized speed of processing (SOP), or is the result of degraded color-vision. The current study investigated the impact of AD on Stroop performance and its potential sources in a meta-analysis and mathematical modeling of 18 studies, comparing 637 AD patients with 977 healthy age-matched participants. We found a significant increase in Stroop effects for AD patients, across studies. This AD-related change was associated with a slowing in SOP. However, after correcting for a bias in the distribution of latencies, SOP could only explain a moderate portion of the total variance (25%). Moreover, we found strong evidence for an AD-related increase in the latency difference between naming the font-color and reading color-neutral stimuli (r2 = 0.98). This increase in the dimensional imbalance between color-naming and word-reading was found to explain a significant portion of the AD-related increase in Stroop effects (r2 = 0.87), hinting on a possible sensory source. In conclusion, our analysis highlights the importance of controlling for sensory degradation and SOP when testing cognitive performance and, specifically, selective attention in AD patients. We also suggest possible measures and tools to better test for selective attention in AD.

Interferometric correction system for a numerically controlled machine

DOEpatents

Burleson, Robert R.

1978-01-01

An interferometric correction system for a numerically controlled machine is provided to improve the positioning accuracy of a machine tool, for example, for a high-precision numerically controlled machine. A laser interferometer feedback system is used to monitor the positioning of the machine tool which is being moved by command pulses to a positioning system to position the tool. The correction system compares the commanded position as indicated by a command pulse train applied to the positioning system with the actual position of the tool as monitored by the laser interferometer. If the tool position lags the commanded position by a preselected error, additional pulses are added to the pulse train applied to the positioning system to advance the tool closer to the commanded position, thereby reducing the lag error. If the actual tool position is leading in comparison to the commanded position, pulses are deleted from the pulse train where the advance error exceeds the preselected error magnitude to correct the position error of the tool relative to the commanded position.

"None of the above" as a correct and incorrect alternative on a multiple-choice test: implications for the testing effect.

PubMed

Odegard, Timothy N; Koen, Joshua D

2007-11-01

Both positive and negative testing effects have been demonstrated with a variety of materials and paradigms (Roediger & Karpicke, 2006b). The present series of experiments replicate and extend the research of Roediger and Marsh (2005) with the addition of a "none-of-the-above" response option. Participants (n=32 in both experiments) read a set of passages, took an initial multiple-choice test, completed a filler task, and then completed a final cued-recall test (Experiment 1) or multiple-choice test (Experiment 2). Questions were manipulated on the initial multiple-choice test by adding a "none-of-the-above" response alternative (choice "E") that was incorrect ("E" Incorrect) or correct ("E" Correct). The results from both experiments demonstrated that the positive testing effect was negated when the "none-of-the-above" alternative was the correct response on the initial multiple-choice test, but was still present when the "none-of-the-above" alternative was an incorrect response.

How to use health and nutrition-related claims correctly on food advertising: comparison of benefit-seeking, risk-avoidance, and taste appeals on different food categories.

PubMed

Choi, Hojoon; Springston, Jeffrey K

2014-09-01

This study applies the concepts of health halos and unhealthy = tasty intuition to examine how the different health and nutrition-related (HNR) appeal types interact with different food product types compared with taste claims. The experiment investigated the impact of benefit-seeking and risk-avoidance HNR appeals compared with that of taste appeals on different food types. The authors found that although respondents evaluated food ads with the two HNR appeals as less risky/more beneficial and healthier than food ads with a taste claim, the respondents showed better ad-related evaluations on the HNR appeals for perceivably healthy food and on taste appeal for perceivably unhealthy food. The findings provide several theoretical and practical implications for health food marketing and public health policy.

Memory Alteration Test to Detect Amnestic Mild Cognitive Impairment and Early Alzheimer’s Dementia in Population with Low Educational Level

PubMed Central

Custodio, Nilton; Lira, David; Herrera-Perez, Eder; Montesinos, Rosa; Castro-Suarez, Sheila; Cuenca-Alfaro, José; Valeriano-Lorenzo, Lucía

2017-01-01

Background/Aims: Short tests to early detection of the cognitive impairment are necessary in primary care setting, particularly in populations with low educational level. The aim of this study was to assess the performance of Memory Alteration Test (M@T) to discriminate controls, patients with amnestic Mild Cognitive Impairment (aMCI) and patients with early Alzheimer’s Dementia (AD) in a sample of individuals with low level of education. Methods: Cross-sectional study to assess the performance of the M@T (study test), compared to the neuropsychological evaluation (gold standard test) scores in 247 elderly subjects with low education level from Lima-Peru. The cognitive evaluation included three sequential stages: (1) screening (to detect cases with cognitive impairment); (2) nosological diagnosis (to determinate specific disease); and (3) classification (to differentiate disease subtypes). The subjects with negative results for all stages were considered as cognitively normal (controls). The test performance was assessed by means of area under the receiver operating characteristic (ROC) curve. We calculated validity measures (sensitivity, specificity and correctly classified percentage), the internal consistency (Cronbach’s alpha coefficient), and concurrent validity (Pearson’s ratio coefficient between the M@T and Clinical Dementia Rating (CDR) scores). Results: The Cronbach’s alpha coefficient was 0.79 and Pearson’s ratio coefficient was 0.79 (p < 0.01). The AUC of M@T to discriminate between early AD and aMCI was 99.60% (sensitivity = 100.00%, specificity = 97.53% and correctly classified = 98.41%) and to discriminate between aMCI and controls was 99.56% (sensitivity = 99.17%, specificity = 91.11%, and correctly classified = 96.99%). Conclusions: The M@T is a short test with a good performance to discriminate controls, aMCI and early AD in individuals with low level of education from urban settings. PMID:28878665

A bias in the "mass-normalized" DTT response - An effect of non-linear concentration-response curves for copper and manganese

NASA Astrophysics Data System (ADS)

Charrier, Jessica G.; McFall, Alexander S.; Vu, Kennedy K.-T.; Baroi, James; Olea, Catalina; Hasson, Alam; Anastasio, Cort

2016-11-01

The dithiothreitol (DTT) assay is widely used to measure the oxidative potential of particulate matter. Results are typically presented in mass-normalized units (e.g., pmols DTT lost per minute per microgram PM) to allow for comparison among samples. Use of this unit assumes that the mass-normalized DTT response is constant and independent of the mass concentration of PM added to the DTT assay. However, based on previous work that identified non-linear DTT responses for copper and manganese, this basic assumption (that the mass-normalized DTT response is independent of the concentration of PM added to the assay) should not be true for samples where Cu and Mn contribute significantly to the DTT signal. To test this we measured the DTT response at multiple PM concentrations for eight ambient particulate samples collected at two locations in California. The results confirm that for samples with significant contributions from Cu and Mn, the mass-normalized DTT response can strongly depend on the concentration of PM added to the assay, varying by up to an order of magnitude for PM concentrations between 2 and 34 μg mL-1. This mass dependence confounds useful interpretation of DTT assay data in samples with significant contributions from Cu and Mn, requiring additional quality control steps to check for this bias. To minimize this problem, we discuss two methods to correct the mass-normalized DTT result and we apply those methods to our samples. We find that it is possible to correct the mass-normalized DTT result, although the correction methods have some drawbacks and add uncertainty to DTT analyses. More broadly, other DTT-active species might also have non-linear concentration-responses in the assay and cause a bias. In addition, the same problem of Cu- and Mn-mediated bias in mass-normalized DTT results might affect other measures of acellular redox activity in PM and needs to be addressed.