Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY13 Fourth Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

2013-12-02

This quarterly report summarizes the status of the project planning to obtain all the approvals required for a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). The final CRADA documents processed by PNNL’s Legal Services were submitted to all the parties for signatures.

Development of Abrasion-Resistant Coating for Solar Reflective Films. Cooperative Research and Development Final Report, CRADA Number CRD-07-247

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, Matthew

The purpose of this CRADA is to develop an abrasion-resistant coating, suitable for use on polymeric-based reflective films (e.g., the ReflecTech reflective film), that allows for improved scratch resistance and enables the use of aggressive cleaning techniques (e.g., direct contact methods like brushing) without damaging the specular reflectance properties of the reflective film.

Development of Isotropic, Micro-Toughened Titanium-Base Intermetallic Composites for High-Temperature Service Final Report CRADA No. TC-0497-93A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nieh, T. G.; Waltz, Z. R.

The purpose of this Cooperative Research and Development Agreement (CRADA) between LLNL and P&W is to develop advanced composites and their processing technologies, resulting in major improviements in the ductility and toughnes of high-strength, high-stiffness TiAl-base composite materials for commercial jet engines and U.S. Department of Energy (DOE) Defense Program applications.

Development of a Laser for Landmine Destruction Final Report CRADA No. TC02126.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamamoto, R.; Sheppard, C.

2017-08-31

This was one of two CRADAs between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and First Alliance Technologies, LLC (First Alliance), to conduct research and development activity toward an integrated system for the detecting, locating, and destroying of landmines and unexploded ordinance using a laser to destroy landmines and unexploded ordinance and First Alliance’s Land Mine Locator (LML) system.

Commercialization Plan Support for Development of Low Cost Vacuum Insulating Glazing: Cooperative Research and Development Final Report, CRADA Number CRD-11-449

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dameron, Arrelaine

During the duration of this CRADA, V-Glass and NREL will partner in testing, analysis, performance forecasting, costing, and evaluation of V-Glass’s GRIPWELD™ process technology for creating a low cost hermetic seal for conventional and vacuum glazing. Upon successful evaluation of hermeticity, V-Glass’s GRIPWELD™ will be evaluated for its potential use in highly insulating window glazing.

Micromagnetic Code Development of Advanced Magnetic Structures Final Report CRADA No. TC-1561-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cerjan, Charles J.; Shi, Xizeng

The specific goals of this project were to: Further develop the previously written micromagnetic code DADIMAG (DOE code release number 980017); Validate the code. The resulting code was expected to be more realistic and useful for simulations of magnetic structures of specific interest to Read-Rite programs. We also planned to further the code for use in internal LLNL programs. This project complemented LLNL CRADA TC-840-94 between LLNL and Read-Rite, which allowed for simulations of the advanced magnetic head development completed under the CRADA. TC-1561-98 was effective concurrently with LLNL non-exclusive copyright license (TL-1552-98) to Read-Rite for DADIMAG Version 2 executablemore » code.« less

Fiber Based Optical Amplifier for High Energy Laser Pulses Final Report CRADA No. TC02100.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Messerly, M.; Cunningham, P.

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Livermore National Laboratory (LLNL), and The Boeing Company to develop an optical fiber-based laser amplifier capable of producing and sustaining very high-energy, nanosecond-scale optical pulses. The overall technical objective of this CRADA was to research, design, and develop an optical fiber-based amplifier that would meet specific metrics.

Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C.

PubMed

Murakami, Chiaki; Mizuno, Satoru; Kado, Sayaka; Sakane, Fumio

2017-06-01

Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. PC-PLC plays pivotal roles in inflammation, carcinogenesis, tumor progression, atherogenesis, and subarachnoid hemorrhage. Although the activity of PC-PLC in mammalian tissues was discovered approximately 40 years ago, neither the protein nor its gene has been identified. In the present study, we developed a non-radioactive enzyme activity assay for PC-PLC based on mass spectrometric detection of DG following HPLC separation. This new liquid chromatography-mass spectrometry (LC-MS) assay directly determines a specific reaction product, 1-palmitoyl-2-oleoyl-DG, that is generated from 1-palmitoyl-2-oleoyl-PC by purified Bacillus cereus PC-PLC. The LC-MS assay offers several advantages including a lower background (0.02% versus 91%), higher signal background ratio (4242 versus 1.06)/signal noise ratio (7494 versus 4.4), higher sensitivity (≥32-fold), and lower limit of quantitation (0.04 pmol versus 0.69 pmol of PC-PLC), than a conventional fluorometric assay, which indirectly detects phosphocholine produced in the reaction. In addition to Bacillus cereus PC-PLC, the LC-MS assay was applicable to the measurement of mammalian PC-PLC prepared from the mouse brain. The radioisotope-free, highly sensitive and precise LC-MS assay for PC-PLC would be useful for the purification and identification of PC-PLC protein. Copyright © 2017 Elsevier Inc. All rights reserved.

Mobile Ocean Test Berth Support: Cooperative Research and Development Final Report, CRADA Number CRD-10-413

DOE Office of Scientific and Technical Information (OSTI.GOV)

LiVecchi, Albert

The Northwest National Marine Renewable Energy Center (NNMREC), headquartered at the Oregon State University, is establishing the capabilities to test prototype wave energy conversion devices in the ocean. This CRADA will leverage the technical expertise and resources at NREL in the wind industry and in ocean engineering to support and enhance the development of the NNMREC Mobile Ocean Test Berth (MOTB). This CRADA will provide direct support to NNMREC by providing design evaluation and review of the MOTB, developing effective protocols for testing of the MOTB and wave energy conversion devices in the ocean, assisting in the specification of appropriatemore » instrumentation and data acquisition packages, and providing guidance on obtaining and maintaining A2LA (American Association for Laboratory Accreditation) accreditation.« less

Manufacturing and Characterization of Ultra Pure Ferrous Alloys Final Report CRADA No. TC02069.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lesuer, D.; McGreevy, T. E.

This CRADA was a.collaborative effort between the Lawrence Livermore National Security LLC (formerly University of California)/Lawrence Livermore National Laboratory (LLNL),and Caterpillar Inc. (CaterpiHar), to further advance levitation casting techniques (developed at the Central Research Institute for Material (CRIM) in St. Petersburg, Russia) for use in manufacturing high purity metal alloys. This DOE Global Initiatives for Proliferation Prevention Program (IPP) project was to develop and demonstrate the levitation casting technology for producing ultra-pure alloys.

High Density, Insensitive Oxidizer With RDX Performance Final Report CRADA No. TC02178.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pagoria, P.; Preda, D.

2017-08-25

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Physical Sciences, Inc. (PSI), to develop a synthesis and evaluate a novel high density, insensitive oxidizer with RDX performance. This CRADA resulted from the award of a Phase I STTR ("STTR") from DOD. In recent years, the synthesis of new energetic heterocyclic compounds to replace the energetic materials currently in the stockpile has received a great amount of attention. The Office of the Secretary of Defense has identified that there is a need to incorporate new energetic materialsmore » in current and future weapon systems in an effort to increase performance and decrease sensitivity. For many of the future weapon systems, incorporation of energetic compounds currently in the stockpile will not provide the desired performance and sensitivity goals. The success of this CRADA may lead to a Phase I option STTR from DOD and to a Phase II STTR from DOD. The goal of this CRADA was to produce and test a novel oxidizer, 2,5,8-trinitroheptazine (TNH).« less

Correlations between serum trypsinogen-2 and pancreatic cancer.

PubMed

Cao, Jianbiao; Xia, Changhong; Cui, Tingting; Guo, Hanbin; Li, Haoran; Ren, Yongqiang; Wang, Shuai

2015-01-01

To investigate associations be- tween serum trypsinogen-2, pancreatitis and pancreatic cancer (PC) and determine cutoff values for PC diagnosis. We recruited 88 patients from Internal Medicine/Surgical Departments of General Military Hospital of Beijing PLA between 12/2009 and 6/2010. Serum samples were collected preoperatively from 23 PC patients, 30 pancreatitis patients and 35 healthy controls. Enzyme-linked immunosorbent assay was used to detect trypsinogen-2 semiquantitatively. Serum trypsinogen-2 levels of PC and pancreatitis patients were significantly higher than those of controls (51.2 ± 80.3, 107.7 ± 98.1 vs. 1.0 ± 0.5, p = 0.03, p < 0.001) and significantly higher in pancreatitis vs. PC patients (107.7 ± 98.1 vs. 51.2 ± 80.3, p = 0.01). Higher Balthazar CT grades correlated with higher trypsinogen-2 in pancreatitis group. ROC curves for trypsinogen-2 revealed optimal cutoff value 1.8 as lower PC detection limit with 95.7% sensitivity and 91.4% specificity, and optimal cutoff value 19.9 for upper PC detection limit with 87.0% sensitivity and 97.1% specificity. Trypsinogen-2 levels correlated with pancreatic injury level. An AUC of 0.73 (95% Cl: 0.59-0.84, p = 0.002) distinguished PC from pancreatitis. Serum trypsinogen-2 is associated with PC and pancreatitis. Levels between 1.8 μg/L and 19.9 μg/L strongly suggest PC. Detection of serum trypsinogen-2 may provide simple, sensitive, specific non-invasive initial screening for early PC diagnosis.

Trinitromethyl Heterocyclic Oxidizers as a Solid Propellant Ingredient Final Report CRADA No TC02146.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pagoria, P.; Racoveanu, A.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Physical Sciences, Inc. (PSI), to develop a synthesis of two novel energetic heterocyclic oxidizers as possible replacements for ammonium perchlorate (AP) in rocket propellant formulations. This CRADA resulted from the award of the Phase I Small Business Technology Transfer (STTR) from DOD. The CRADA consisted of two phases. The goal for Phase 1 was to produce a new oxidizer called TNMDNP. Phase 2 is optional (based on the success of Phase 1) and the goal of Phase 2more » (optional) was to produce a new oxidizer called TNMDNT. Phase 2 tasks would be performed based on the successful results of Phase 1.« less

Computational fluid dynamic comparison between patch-based and primary closure techniques after carotid endarterectomy.

PubMed

Domanin, Maurizio; Bissacco, Daniele; Le Van, Davide; Vergara, Christian

2018-03-01

The aim of the study was to provide, by means of computational fluid dynamics, a comparative analysis after carotid endarterectomy (CEA) between patch graft (PG) and primary closure (PC) techniques performed in real carotid geometries to identify disturbed flow conditions potentially involved in the development of restenosis. Eight carotid geometries in seven asymptomatic patients who underwent CEA were analyzed. In six cases (A-F), CEA was performed using PG closure; in two cases (G and H), PC was performed. Three-dimensional carotid geometries, derived from postoperative magnetic resonance angiography, were reconstructed, and a computational fluid dynamics analysis was performed. A virtual scenario with PC closure was designed in patients in whom PG was originally inserted and vice versa. This allowed us to compare for each patient hemodynamic effects in the PG and PC scenarios in terms of oscillatory shear index (OSI) and relative residence time (RRT), considered indicators of disturbed flow. For the six original PG cases, the mean averaged-in-space OSI was 0.07 ± 0.01 for PG and 0.03 ± 0.02 for virtual-PC (difference, 0.04 ± 0.01; P = .0016). The mean of the percentage of area (%A) with OSI >0.2 resulted in 10.08% ± 3.38% for PG and 3.80% ± 3.22% for virtual-PC (difference, 6.28 ± 1.91; P = .008). For the same cases, the mean of the averaged-in-space RRT resulted in 5.48 ± 3.40 1/Pa for PG and 2.62 ± 1.12 1/Pa for virtual-PC (difference, 2.87 ± 1.46; P = .097). The mean of %A RRT >4.0 1/Pa resulted in 26.53% ± 12.98% for PG and 9.95% ± 6.53% for virtual-PC (difference, 16.58 ± 5.93; P = .025). For the two original PC cases, the averaged-in-space OSIs were 0.02 and 0.04 for PC and 0.03 and 0.02 for virtual-PG; the %A OSIs >0.2 were 0.9% and 7.6% for PC and 3.0% and 2.2% for virtual-PG; the averaged-in-space RRTs were 1.8 and 2.0 1/Pa for PC and 2.9 and 1.9 1/Pa for virtual-PG; the %A RRTs >4.0 1/Pa were 6.8% and 9.8% for PC and 9.4% and 6.2% for virtual-PG. These results revealed generally higher disturbed flows in the PG configurations with respect to the PC ones. OSI and RRT values were generally higher in PG cases with respect to PC, especially for high carotids or when the arteriotomy is mainly at the bulb region. Thus, an elective use of patch should be considered to prevent disturbed flows. Copyright © 2017 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Advanced Analog Signal Processing for Fuzing Final Report CRADA No. TC-1306-96

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fu, C. Y.; Spencer, D.

The purpose of this CRADA between LLNL and Kaman Aerospace/Raymond Engineering Operations (Raymond) was to demonstrate the feasibility of using Analog/Digital Neural Network (ANN) Technology for advanced signal processing, fuzing, and other applications. This cooperation sought to Ieverage the expertise and capabilities of both parties--Raymond to develop the signature recognition hardware system, using Raymond’s extensive experience in the area of system development plus Raymond’s knowledge of military applications, and LLNL to apply ANN and related technologies to an area of significant interest to the United States government. This CRADA effort was anticipated to be a three-year project consisting of threemore » phases: Phase I, Proof-of-Principle Demonstration; Phase II, Proof-of-Design, involving the development of a form-factored integrated sensor and ANN technology processo~ and Phase III, Final Design and Release of the integrated sensor and ANN fabrication process: Under Phase I, to be conducted during calendar year 1996, Raymond was to deliver to LLNL an architecture (design) for an ANN chip. LLNL was to translate the design into a stepper mask and to produce and test a prototype chip from the Raymond design.« less

Nano-Filament Field Emission Cathode Development Final Report CRADA No. TSB-0731-93

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernhardt, Tony; Fahlen, Ted

At the time the CRADA was established, Silicon Video Corporation, of Cupertino, CA was a one-year-old rapidly growing start-up company. SVC was developing flat panel displays (FPDs) to replace Cathode Ray Terminals (CRTs) for personal computers, work stations and televisions. They planned to base their products on low cost and energy efficient field emission technology. It was universally recognized that the display was both the dominant cost item and differentiating feature of many products such as laptop computers and hand-held electronics and that control of the display technology through U.S. sources was essential to success in these markets. The purposemore » of this CRADA project was to determine if electrochemical planarization would be a viable, inexpensive alternative to current optical polishing techniques for planarizing the surface of a ceramic backplate of a thin film display.« less

H2@Scale Laboratory CRADA Call | Hydrogen and Fuel Cells | NREL

Science.gov Websites

research and development agreement (CRADA) projects with the Hydrogen at Scale (H2@Scale) national CRADA Call H2@Scale CRADA Agreement Template Responses to CRADA Call Questions: Part 1 (includes

Improved Advanced Actuated Hybrid Mirrors Final Report CRADA No. TC02130.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbee, T. W.; Ealey, M. A.

2017-08-25

This was a collaborative effort to develop and demonstrate an improved Advanced Actuated Hybrid Mirrors (AAHM) for commercial or Government purposes. The AAHM consists of a nanolaminate film replicating a precision optical surface bonded to a Silicon Carbide (SiC) substrate with active figure control capability. The goal of this project was to further the development of specific AAHM technologies. The intent of the CRADA was to combine the expertise of LLNL and NG Xinetics in the manufacture and test of a very high quality AAHM, incorporating lessons learned from earlier joint efforts.

Development of Personal Decontamination System Final Report CRADA No. TC-02078-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, W. J.; O'Dell, P.

2017-09-27

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and O’Dell Engineering, Ltd. (O’Dell) to develop an improved low-cost personal decontamination system for Toxic Industrial Chemicals (TICs) and chemical agents. The significant change to the project was that COTS (Commercial Off-the Shelf Components) were identified that performed as well, or better than, the proprietary materials created and tested as part of this CRADA. These COTS components were combined to create a new LPDS (low-cost personal decontamination system) that met all specifications.

TRANSCRIPTIONAL PROFILING USING THE FLOWTHROUGH GENOSENSOR FINAL CRADA REPORT C/ORNL97-00472

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doktycz, M. J.; Yang, H.

1999-06-01

A Cooperative Research and Development Agreement (CRADA) between Lockheed Martin Energy Research Corporation (Contractor) and Gene Logic, Inc., (Participant) was carried out to evaluate the technical feasibility study of the application of the flowthrough genosensor for gene expression (transcriptional) profiling, over the current industry practice of using flat surface hybridization arrays to monitor the relative abundance of individual mRNA species in a cell. Various parameters, including substrate preparation, flow rates, hybridization conditions and sample concentrations, were evaluated on the flowthrough genosensor. The superiority of the flowthrough genosensor, in terms of hybridization rate and sensitivity were established.

Equipment Only - Solar Resources Measurements at the University of Texas at Austin, TX: Cooperative Research and Development Final Report, CRADA Number CRD-07-222

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoffel, T.

Faculty and staff at the University of Texas at Austin collected solar resource measurements at their campus using equipment on loan from the National Renewable Energy Laboratory. The equipment was used to train students on the operation and maintenance of solar radiometers and was returned to NREL's Solar Radiation Research Laboratory upon completion of the CRADA. The resulting data augment the solar resource climatology information required for solar resource characterizations in the U.S. The cooperative agreement was also consistent with NREL's goal of developing an educated workforce to advance renewable energy technologies.

High Resolution Sub-MM Fiberoptic Endoscope Final Report CRADA No. TSB-1447-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, Gary F.; Smith, John

2018-01-22

At the time of the CRADA, LLNL needed to develop a sub-mm outer diameter fiberoptic endoscope with 25pm or better resolution at 3-lOmm working distance to support the Enhanced Surveillance Program (ESP) and the Core Surveillance Program for DOE. The commercially available systems did not meet the image resolution requirements and development work was needed to reach three goals. We also needed to perform preliminary investigations into the production of such an endoscope with a steerable-articulated distal end. The goal of such an endoscope was to allow for a 45 degree inspection cone including the lens field of view.

Conversion of Indigenous Agricultural Waste Feedstocks to Fuel Ethanol. Cooperative Research and Development Final Report, CRADA Number CRD-13-504

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elander, Richard

This Cooperative Research and Development Agreement (CRADA) is between the National Renewable Energy Laboratory (NREL), a world leader in biomass conversion research and Ecopetrol American Inc., Ecopetrol S.A.'s U.S. subsidiary. The research and development efforts described in the Joint Work Statement (JWS) will take advantage of the strengths of both parties. NREL will use its Integrated Biorefinery Facility and vast experience in the conversion of lignocellulosic feedstocks to fuel ethanol to develop processes for the conversion of Ecopetrol's feedstocks. Ecopetrol will establish the infrastructure in Columbia to commercialize the conversion process.

KSC-98pc461

NASA Image and Video Library

1998-04-10

STS-91 Mission Specialists Franklin Chang-Diaz, Ph.D., and Janet Kavandi, Ph.D., participate in the Crew Equipment Interface Test, or CEIT, inside an airlock in KSC's Orbiter Processing Facility Bay 2. During CEIT, the crew have an opportunity to get a hands-on look at the payloads with which they'll be working on-orbit. The STS-91 crew are scheduled to launch aboard the Shuttle Discovery for the ninth and final docking with the Russian Space Station Mir from KSC's Launch Pad 39A on May 28 at 8:05 EDT

Scale Up of Malonic Acid Fermentation Process: Cooperative Research and Development Final Report, CRADA Number CRD-16-612

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schell, Daniel J

The goal of this work is to use the large fermentation vessels in the National Renewable Energy Laboratory's (NREL) Integrated Biorefinery Research Facility (IBRF) to scale-up Lygos' biological-based process for producing malonic acid and to generate performance data. Initially, work at the 1 L scale validated successful transfer of Lygos' fermentation protocols to NREL using a glucose substrate. Outside of the scope of the CRADA with NREL, Lygos tested their process on lignocellulosic sugars produced by NREL at Lawrence Berkeley National Laboratory's (LBNL) Advanced Biofuels Process Development Unit (ABPDU). NREL produced these cellulosic sugar solutions from corn stover using amore » separate cellulose/hemicellulose process configuration. Finally, NREL performed fermentations using glucose in large fermentors (1,500- and 9,000-L vessels) to intermediate product and to demonstrate successful performance of Lygos' technology at larger scales.« less

Enhanced control and sensing for the REMOTEC ANDROS Mk VI robot. CRADA final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spelt, P.F.; Harvey, H.W.

1998-08-01

This Cooperative Research and Development Agreement (CRADA) between Lockheed Martin Energy Systems, Inc., and REMOTEC, Inc., explored methods of providing operator feedback for various work actions of the ANDROS Mk VI teleoperated robot. In a hazardous environment, an extremely heavy workload seriously degrades the productivity of teleoperated robot operators. This CRADA involved the addition of computer power to the robot along with a variety of sensors and encoders to provide information about the robot`s performance in and relationship to its environment. Software was developed to integrate the sensor and encoder information and provide control input to the robot. ANDROS Mkmore » VI robots are presently used by numerous electric utilities to perform tasks in reactors where substantial exposure to radiation exists, as well as in a variety of other hazardous environments. Further, this platform has potential for use in a number of environmental restoration tasks, such as site survey and detection of hazardous waste materials. The addition of sensors and encoders serves to make the robot easier to manage and permits tasks to be done more safely and inexpensively (due to time saved in the completion of complex remote tasks). Prior research on the automation of mobile platforms with manipulators at Oak Ridge National Laboratory`s Center for Engineering Systems Advanced Research (CESAR, B&R code KC0401030) Laboratory, a BES-supported facility, indicated that this type of enhancement is effective. This CRADA provided such enhancements to a successful working teleoperated robot for the first time. Performance of this CRADA used the CESAR laboratory facilities and expertise developed under BES funding.« less

Building Diagnostic Market Deployment - Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katipamula, S.; Gayeski, N.

2012-04-30

Operational faults are pervasive across the commercial buildings sector, wasting energy and increasing energy costs by up to about 30% (Mills 2009, Liu et al. 2003, Claridge et al. 2000, Katipamula and Brambley 2008, and Brambley and Katipamula 2009). Automated fault detection and diagnostic (AFDD) tools provide capabilities essential for detecting and correcting these problems and eliminating the associated energy waste and costs. The U.S. Department of Energy's (DOE) Building Technology Program (BTP) has previously invested in developing and testing of such diagnostic tools for whole-building (and major system) energy use, air handlers, chillers, cooling towers, chilled-water distribution systems, andmore » boilers. These diagnostic processes can be used to make the commercial buildings more energy efficient. The work described in this report was done as part of a Cooperative Research and Development Agreement (CRADA) between the U.S. Department of Energy's Pacific Northwest National Laboratory (PNNL) and KGS Building LLC (KGS). PNNL and KGS both believe that the widespread adoption of AFDD tools will result in significant reduction to energy and peak energy consumption. The report provides an introduction and summary of the various tasks performed under the CRADA. The CRADA project had three major focus areas: (1) Technical Assistance for Whole Building Energy Diagnostician (WBE) Commercialization, (2) Market Transfer of the Outdoor Air/Economizer Diagnostician (OAE), and (3) Development and Deployment of Automated Diagnostics to Improve Large Commercial Building Operations. PNNL has previously developed two diagnostic tools: (1) whole building energy (WBE) diagnostician and (2) outdoor air/economizer (OAE) diagnostician. WBE diagnostician is currently licensed non-exclusively to one company. As part of this CRADA, PNNL developed implementation documentation and provided technical support to KGS to implement the tool into their software suite, Clockworks. PNNL also provided validation data sets and the WBE software tool to validate the KGS implementation. OAE diagnostician automatically detects and diagnoses problems with outdoor air ventilation and economizer operation for air handling units (AHUs) in commercial buildings using data available from building automation systems (BASs). As part of this CRADA, PNNL developed implementation documentation and provided technical support to KGS to implement the tool into their software suite. PNNL also provided validation data sets and the OAE software tool to validate the KGS implementation. Finally, as part of this CRADA project, PNNL developed new processes to automate parts of the re-tuning process and transfer those process to KGS for integration into their software product. The transfer of DOE-funded technologies will transform the commercial buildings sector by making buildings more energy efficient and also reducing the carbon footprint from the buildings. As part of the CRADA with PNNL, KGS implemented the whole building energy diagnostician, a portion of outdoor air economizer diagnostician and a number of measures that automate the identification of re-tuning measures.« less

Percutaneous cholecystostomy for high-risk patients with acute cholangitis.

PubMed

Li, Yan-Lin; Wong, Kin-Hoi; Chiu, Keith Wan-Hang; Cheng, Andrew Kai-Chun; Cheung, Ronald Kin-On; Yam, Max Kai-Ho; Chan, Angie Lok-Chi; Chan, Victor Siang-Hua; Law, Martin Wai-Ming; Lee, Paul Sing-Fun

2018-05-01

Percutaneous cholecystostomy (PC) is a well-established treatment for acute cholecystitis. We investigate the performance and role of PC in managing acute cholangitis.Retrospective review on all patients who underwent PC for acute cholangitis between January 2012 and June 2017 at a major regional hospital in Hong Kong.Thirty-two patients were included. The median age was 84 years and median American Society of Anaesthesiologists (ASA) physical status was Class III (severe systemic disease). All fulfilled Tokyo Guidelines 2013 (TG13) diagnostic criteria for moderate or severe cholangitis. Eighty-four percent of the patients were shown to have lower common bile duct stones on imaging. The majority had previously failed intervention by endoscopic retrograde cholangiopancreatography (38%), percutaneous transhepatic biliary drainage (38%), or both (13%)The technical success rate for PC was 100% with no procedure-related mortality. The overall 30-day mortality was 9%. Rest of the patients (91%) had significant improvement in clinical symptoms and could be discharged with median length of stay of 14 days. Significant postprocedural biochemical improvement was observed in terms of white cell count (P < .001), serum bilirubin (P < .001), alkaline phosphatase (P = .001), and alanine transaminase levels (P < .001). Time from admission to PC was associated with excess mortality (P = .002).PC is an effective treatment for acute cholangitis in high-risk elderly patients. Early intervention is associated with lower mortality. PC is particularly valuable as a temporising measure before definitive treatment in critical patients or as salvage therapy where other methods endoscopic retrograde cholangiopancreatography/percutaneous transhepatic biliary drainage (ERCP/PTBD) have failed.

KSC-98pc538

NASA Image and Video Library

1998-04-27

The orbiter Discovery sits in the transfer aisle of KSC's Vehicle Assembly Building as it awaits being attached to the yellow hoist and crane for lifting into a vertical position. Once standing upright, Discovery will be mated with an orange external tank and two white solid rocket boosters, transforming the orbiter into the Space Shuttle Discovery, slated for launch on STS-91, the ninth and final docking mission with the Russian Space Station Mir. The six-member crew of STS-91 will dock with Mir and pick up Mission Specialist Andrew Thomas, Ph.D., who will have been on Mir about four months, to return him to Earth. STS-91 is scheduled to launch June 2 at about 6:04 p.m. EDT

Interventional Application of Shape Memory Polymer Foam Final Report CRADA No. TC-02067-03

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maitland, D.; Metzger, M. F.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Sierra Interventions, LLC, to develop shape memory polymer foam devices for treating hemorrhagic stroke.

Development of a laser Doppler displacement encoder system with ultra-low-noise-level for linear displacement measurement with subnanometer resolution - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shu, Deming

An U.S. DOE Cooperative Research and Development Agreement (CRADA) between ANL and Optodyne, Inc. has been established to develop a prototype laser Doppler displacement encoder system with ultra-low noise level for linear measurements to sub-nanometer resolution for synchrotron radiation applications. We have improved the heterodyne efficiency and reduced the detector shot noises by proper shielding and adding a low-pass filter. The laser Doppler displacement encoder system prototype demonstrated a ~ 1 nm system output noise floor with single reflection optics. With multiple-pass optical arrangement, 0.1 nm scale closed-loop feedback control is achieved.

KSC-98pc466

NASA Image and Video Library

1998-04-10

STS-91 crew members participate in the Crew Equipment Interface Test, or CEIT, in KSC's Orbiter Processing Facility Bay 2. Laying down inspecting a foot restraint for an extravehicular activity (EVA) spacewalk is STS-91 Mission Specialist Franklin Chang-Diaz, Ph.D. Looking over his shoulder is Kieth Johnson, an EVA trainer and flight controller from Johnson Space Center. STS-91 Mission Specialist Janet Kavandi, Ph.D., stands next to Johnson. During CEIT, the crew have an opportunity to get a hands-on look at the payloads with which they'll be working on-orbit. The STS-91 crew are scheduled to launch aboard the Shuttle Discovery for the ninth and final docking with the Russian Space Station Mir from KSC's Launch Pad 39A on May 28 at 8:05 EDT

Frito-Lay North America/NREL CRADA: Cooperative Research and Development Final Report, CRADA Number CRD-06-176

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, A.

2013-06-01

Frito Lay North America (FLNA) requires technical assistance for the evaluation and implementation of renewable energy and energy efficiency projects in production facilities and distribution centers across North America. Services provided by NREL do not compete with those available in the private sector, but rather provide FLNA with expertise to create opportunities for the private sector renewable/efficiency industries and to inform FLNA decision making regarding cost-effective projects. Services include: identifying the most cost-effective project locations based on renewable energy resource data, utility data, incentives and other parameters affecting projects; assistance with feasibility studies; procurement specifications; design reviews; and other servicesmore » to support FNLA in improving resource efficiency at facilities. This Cooperative Research and Development Agreement (CRADA) establishes the terms and conditions under which FLNA may access capabilities unique to the laboratory and required by FLNA. Each subsequent task issued under this umbrella agreement would include a scope-of-work, budget, schedule, and provisions for intellectual property specific to that task.« less

Technology Assessment for Powertrain Components Final Report CRADA No. TC-1124-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tokarz, F.; Gough, C.

LLNL utilized its defense technology assessment methodologies in combination with its capabilities in the energy; manufacturing, and transportation technologies to demonstrate a methodology that synthesized available but incomplete information on advanced automotive technologies into a comprehensive framework.

Pulsed Plasma Processing of Diesel Engine Exhaust Final Report CRADA No. TC-0336-92-1-C

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merritt, Bernard T.; Broering, Louis

The goal was to develop an exhaust-gas treatment process for the reduction of NO x and hydrocarbon from diesel engines. The project began believing that direct chemical reduction on NO x was possible through the use of non-thermal plasmas. The original CRADA began in 1993 and was scheduled to finish in 1996. It had as its goals three metrics: 1) remove two grams/brake-horse-power-hour of NOx, 2) have no more than five percent energy penalty, and 3) cost no more than ten percent of the engine cost. These goals were all aimed at heavy-duty diesel trucks. This CRADA had its Defensemore » Program funding eliminated by DOE prior to completion in 1995. Prior to loss of funding from DOE, LLNL discovered that due to the large oxygen content in diesel exhaust, direct chemical reduction was not possible. In understanding why, a breakthrough was achieved that combined the use of a non-thermal plasma and a catalyst. This process was named Plasma Assisted Catalytic Reduction (P ACR). Because of this breakthrough, the CRADA became a funds-in only CRADA, once DOE DP funding ended. As a result, the funding decreased from about 1M dollars per year to about $400k per year. Subsequently, progress slowed as well. The CRADA was amended several times to reflect the funds-in nature. At each amendment, the deliverables were modified; the goals remained the same but the focus changed from heavy-duty to lightduty to SUVs. The diesel-engine NO x problem is similar to the furnace and boiler NO x emission problem with the added constraint that ammonia-like additives are impractical for a mobile source. Lean-burning gasoline engines are an additional area of application because the standard three-way catalyst is rendered ineffective by the presence of oxygen. In the P ACR process an electrical discharge is used to create a non-thermal plasma that contains oxidative radicals O and OH. These oxidative radicals convert NO to NO 2. Selective catalytic reduction using a readily available catalyst then converts the NO 2 to harmless gases, N 2 and 0 2.« less

A Compact, Portable, Reduced-Cost, Gamma Ray Spectroscopic System for Nuclear Verification Final Report CRADA No. TSB-1551-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lavietes, A.; Kalkhoran, N.

The overall goal of this project was to demonstrate a compact gamma-ray spectroscopic system with better energy resolution and lower costs than scintillator-based detector systems for uranium enrichment analysis applications.

Development of Operational Free-Space-Optical (FSO) Laser Communication Systems Final Report CRADA No. TC02093.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruggiero, A.; Orgren, A.

This project was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Livermore National Laboratory (LLNL) and LGS Innovations, LLC (formerly Lucent Technologies, Inc.), to develop long-range and mobile operational free-space optical (FSO) laser communication systems for specialized government applications. LLNL and LGS Innovations formerly Lucent Bell Laboratories Government Communications Systems performed this work for a United States Government (USG) Intelligence Work for Others (I-WFO) customer, also referred to as "Government Customer", or "Customer" and "Government Sponsor." The CRADA was a critical and required part of the LLNL technology transfer plan formore » the customer.« less

NREL/University of Delaware Offshore Wind R&D Collaboration: Cooperative Research and Development Final Report, CRADA Number CRD-10-393

DOE Office of Scientific and Technical Information (OSTI.GOV)

Musial, Walt

2015-11-12

Specifically, the work under this CRADA includes, but is not limited to, the development of test procedures for an offshore test site in Delaware waters; testing of installed offshore wind turbines; performance monitoring of those turbines; and a program of research and development on offshore wind turbine blades, components, coatings, foundations, installation and construction of bottom-fixed structures, environmental impacts, policies, and more generally on means to enhance the reliability, facilitate permitting, and reduce costs for offshore wind turbines. This work will be conducted both at NREL's National Wind Technology Center and participant facilities, as well as the established offshore windmore » test sites.« less

Characterization of the Tribological Behavior of Oxide-Based NanoMaterials: Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fenske, George

2017-01-04

Under the Argonne/Pixelligent cooperative research and development agreement (CRADA – C1200801), Argonne performed labscale tribological tests on proprietary nano-sized ZrO 2 material developed by Pixelligent. Pixelligent utilized their proprietary process to prepare variants with different surfactants at different loadings in different carrier fluids for testing and evaluation at Argonne. Argonne applied a range of benchtop tribological test rigs to evaluate friction and wear under a range of conditions (contact geometry, loads, speeds, and temperature) that simulated a broad range of conditions experienced in engines and driveline components. Post-test analysis of worn surfaces provided information on the structure and chemistry ofmore » the tribofilms produced during the tests.« less

Numerical Simulations of 3D Seismic Data Final Report CRADA No. TC02095.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedmann, S. J.; Kostov, C.

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of Califomia)/Lawrence-Livermore National Laboratory (LLNL) and Schlumberger Cambridge Research (SCR), to develop synthetic seismic data sets and supporting codes.

Ceramic High Efficiency Particulate Air (HEPA) Filter Final Report CRADA No. TC02160.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, M.; Bergman, W.

2017-08-25

The technical objective of this project was to develop a ceramic HEPA filter technology, by initially producing and testing coupon ceramics, small scale prototypes, and full scale prototype HEPA filters, and to address relevant manufacturing and commercialization technical issues.

Development of DNA Pillar Chip Final Report CRADA No. TSB-2035-01

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ness, K. D.; Long, G. W.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Tetracore, to demonstrate a proof of principal device for the capture and controlled release of DNA moving within a flow stream.

Surface Inspection Machine Infrared (SIMIR). Final CRADA report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Powell, G.L.; Neu, J.T.; Beecroft, M.

This Cooperative Research and Development Agreement was a one year effort to make the surface inspection machine based on diffuse reflectance infrared spectroscopy (Surface Inspection Machine-Infrared, SIMIR), being developed by Surface Optics Corporation, perform to its highest potential as a practical, portable surface inspection machine. The design function of the SIMIR is to inspect metal surfaces for cleanliness (stains). The system is also capable of evaluating graphite-resin systems for cure and heat damage, and for measuring the effects of moisture exposure on lithium hydride, corrosion on uranium metal, and the constituents of and contamination on wood, paper, and fabrics. Overmore » the period of the CRADA, extensive experience with the use of the SIMIR for surface cleanliness measurements have been achieved through collaborations with NASA and the Army. The SIMIR was made available to the AMTEX CRADA for Finish on Yarn where it made a very significant contribution. The SIMIR was the foundation of a Forest Products CRADA that was developed over the time interval of this CRADA. Surface Optics Corporation and the SIMIR have been introduced to the chemical spectroscopy on-line analysis market and have made staffing additions and arrangements for international marketing of the SIMIR as an on-line surface inspection device. LMES has been introduced to a wide range of aerospace applications, the research and fabrication skills of Surface Optics Corporation, has gained extensive experience in the areas of surface cleanliness from collaborations with NASA and the Army, and an extensive introduction to the textile and forest products industries. The SIMIR, marketed as the SOC-400, has filled an important new technology need in the DOE-DP Enhanced Surveillance Program with instruments delivered to or on order by LMES, LANL, LLNL, and Pantex, where extensive collaborations are underway to implement and improve this technology.« less

Treatment of Produced Water From Coal-Bed Methane Production Using Capacitive Deionization Final Report CRADA No. TSV-1380-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tran, T. D.; Patton, C. C.

The production af Coal-Bed Methane (CBM) is always accompanied by the production of large amounts of water. The produced water is typically too high in dissolved solids and salinity to be suitable for surface disposal.

Laser Drilling Development Trial Final Report CRADA No. TSB-1538-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hermann, M. R.; Hebbar, R. R.

This project performed various laser drilling tests to demonstrate femtosecond laser drilling of fuel injector nozzles with minimal recast, minimal heat affected zone and no collateral damage. LLNL had extensive experience in ultra short-pulse laser systems and developed specialized hardware for these applications.

Development of Weldable Superplastic Forming Aluminum Alloy Sheet Final Report CRADA No. TC-1086-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lesuer, D.; Sun, T. C.

Numerous applications could exist for superplastic formable, weldable aluminum alloys in the automotive, aerospace, architectural, and construction industries. In this project, LLNL and Kaiser worked with the Institute for Metals Superplasticity Problems to develop and evaluate weldable superplastic alloys.

Phase II, Compact AMS System for Biological Tracer Detection Final Report CRADA No. TSV-1533-96

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, T. A.; Hamm, R. W.

2017-11-01

The objective of this collaboration between LLNL and AccSys Technology, Inc. of Pleasanton, California was to build and demonstrate a low cost, compact tritium (3H) Accelerator Mass Spectrometer (AMS) system matched to the requirements of biomedical research.

KSC-98pc521

NASA Image and Video Library

1998-04-21

Processing activities for STS-91 continue in KSC's Orbiter Processing Facility Bay 2. Two Get Away Special (GAS) canisters are shown after their installation into Discovery's payload bay. At left is G-090, containing three educational experiments sponsored by Utah State University, and at right is G-743, an experiment sponsored by Broward Community College in Florida to test DNA exposed to cosmic radiation in a microgravity environment. STS-91 is scheduled to launch aboard the Space Shuttle Discovery for the ninth and final docking with the Russian Space Station Mir from KSC's Launch Pad 39A on June 2 with a launch window opening around 6:04 p.m. EDT

Enhanced control & sensing for the REMOTEC ANDROS Mk VI robot. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spelt, P.F.; Harvey, H.W.

1997-08-01

This Cooperative Research and Development Agreement (CRADA) between Lockheed Marietta Energy Systems, Inc., and REMOTEC, Inc., explored methods of providing operator feedback for various work actions of the ANDROS Mk VI teleoperated robot. In a hazardous environment, an extremely heavy workload seriously degrades the productivity of teleoperated robot operators. This CRADA involved the addition of computer power to the robot along with a variety of sensors and encoders to provide information about the robot`s performance in and relationship to its environment. Software was developed to integrate the sensor and encoder information and provide control input to the robot. ANDROS Mkmore » VI robots are presently used by numerous electric utilities to perform tasks in reactors where substantial exposure to radiation exists, as well as in a variety of other hazardous environments. Further, this platform has potential for use in a number of environmental restoration tasks, such as site survey and detection of hazardous waste materials. The addition of sensors and encoders serves to make the robot easier to manage and permits tasks to be done more safely and inexpensively (due to time saved in the completion of complex remote tasks). Prior research on the automation of mobile platforms with manipulators at Oak Ridge National Laboratory`s Center for Engineering Systems Advanced Research (CESAR, B&R code KC0401030) Laboratory, a BES-supported facility, indicated that this type of enhancement is effective. This CRADA provided such enhancements to a successful working teleoperated robot for the first time. Performance of this CRADA used the CESAR laboratory facilities and expertise developed under BES funding.« less

Fixed-Abrasive Grinding of Thin-Film Recording Heads Final Report CRADA No. TC-0498-93

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blaedel, K. L.; Newman, C.

The goals of this project were (1) to significantly reduce the cost of manufacturing thin-film recording heads for magnetic storage media and (2) to meet the stringent dimensional tolerances required for heads in the next generation high-density disc drives.

Microwave Sintering of Ceramic Materials for Industrial Application Final Report CRADA No. TC-1116-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caplan, M.; Tandon, R.; Callis, R.

The goal of this project was to develop the commercial capability in the US to sinter alumina oxide ceramic parts for the semiconductor manufacturing equipment industry. We planned to use the millimeter microwave (30 GHz) sintering system first developed by IAP in Russia.

Commercialization of Ultra-Hard Ceramics for Cutting Tools Final Report CRADA No. TC0279.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landingham, R.; Neumann, T.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Greenleaf Corporation (Greenleaf) to develop the technology for forming unique precursor nano-powders process that can be consolidated into ceramic products for industry. LLNL researchers have developed a solgel process for forming nano-ceramic powders. The nano powders are highly tailorable, allowing the explicit design of desired properties that lead to ultra hard materials with fine grain size. The present CRADA would allow the two parties to continue the development of the sol-gel process and the consolidation process in ordermore » to develop an industrially sound process for the manufacture of these ultra-hard materials.« less

Advanced Borobond™ Shields for Nuclear Materials Containment and Borobond™ Immobilization of Volatile Fission Products - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagh, Arun S.

2016-05-19

Borobond is a company-proprietary material developed by the CRADA partner in collaboration with Argonne, and is based on Argonne's Ceramicrete technology. It is being used by DOE for nuclear materials safe storage, and Boron Products, LLC is the manufacturer and supplier of Borobond. The major objective of this project was to produce a more versatile composition of this material and find new applications. Major target applications were use for nuclear radiation shields, such as in dry storage casks; use in immobilization of most difficult waste streams, such as Hanford K-Basin waste; use for soluble and volatile fission products, such asmore » Cs, Tc, Sr, and I; and use for corrosion and fire protection applications in nuclear facilities.« less

CRADAs: They're Not Just for NCI Anymore | Poster

Cancer.gov

By Karen Surabian, Thomas Stackhouse, and Jeffrey Thomas, Contributing Writers, and Bruce Crise, Guest Writer Advancing scientific discovery is increasingly dependent on diverse and innovative partnerships, and the Cooperative Research and Development Agreement (CRADA) is an essential tool for establishing partnerships. CRADAs allow a federal laboratory to enter into

HCCI Combustion Engines Final Report CRADA No. TC02032.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aceves, S.; Lyford-Pike, E.

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Livermore National Laboratory (LLNL) and Cummins Engine Company (Cwnmins), to advance the state of the art on HomogeneousCharge Compression-Ignition (HCCI) engines, resulting in a clean, high-efficiency alternative to diesel engines.

Automated System for Aneuploidy Detection in Sperm Final Report CRADA No. TC-1364-96: Phase I SBIR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wyrobek, A. J.; Dunlay, R. T.

This project was a relationship between Lawrence Livermore National Laboratory (LLNL) and Biological Detection, Inc. (now known as Cellomics, Inc.) It was funded as a Phase I SBIR from the National Institutes of Health (NIH) awarded to Cellomics, Inc. with a subcontract to LLNL.

Energy Systems Integration News | Energy Systems Integration Facility |

Science.gov Websites

Aids Solar Power in Hawaii Inverter load rejection overvoltage tests completed by NREL with partner the report, Inverter Load Rejection Over-Voltage Testing: SolarCity CRADA Task 1a Final Report. Based % of minimum daytime load (MDL) to 250% of MDL. If those increases are implemented, they will represent

Rapid Assessment of Individual Soldier Operational Readiness Final Report CRADA No. TC02104.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turteltaub, K.; Mapes, J.

This was a collaborative effort between Lawrence Livermore National Security (LLNS) (formerly The Regents of the University of California), Lawrence Livermore National Laboratory (LLNL) and Rules Based Medicine, Inc. {RBM), to identify markers in blood that would be candidates for determining the combat readiness of troops.

CRADA Final Report for CRADA Number ORNL00-0605: Advanced Engine/Aftertreatment System R&D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pihl, Josh A; West, Brian H; Toops, Todd J

2011-10-01

Navistar and ORNL established this CRADA to develop diesel engine aftertreatment configurations and control strategies that could meet emissions regulations while maintaining or improving vehicle efficiency. The early years of the project focused on reducing the fuel penalty associated with lean NOx trap (LNT), also known as NOx adsorber catalyst regeneration and desulfation. While Navistar pursued engine-based (in-cylinder) approaches to LNT regeneration, complementary experiments at ORNL focused on in-exhaust fuel injection. ORNL developed a PC-based controller for transient electronic control of EGR valve position, intake throttle position, and actuation of fuel injectors in the exhaust system of a Navistar enginemore » installed at Oak Ridge. Aftertreatment systems consisting of different diesel oxidation catalysts (DOCs) in conjunction with a diesel particle filter and LNT were evaluated under quasi-steady-state conditions. Hydrocarbon (HC) species were measured at multiple locations in the exhaust system with Gas chromatograph mass spectrometry (GC-MS) and Fourier transform infrared (FTIR) spectroscopy. Under full-load, rated speed conditions, injection of fuel upstream of the DOC reduced the fuel penalty for a given level of NOx reduction by 10-20%. GC-MS showed that fuel compounds were 'cracked' into smaller hydrocarbon species over the DOC, particularly light alkenes. GC-MS analysis of HC species entering and exiting the LNT showed high utilization of light alkenes, followed by mono-aromatics; branched alkanes passed through the LNT largely unreacted. Follow-on experiments at a 'road load' condition were conducted, revealing that the NOx reduction was better without the DOC at lower temperatures. The improved performance was attributed to the large swings in the NOx adsorber core temperature. Split-injection experiments were conducted with ultra-low sulfur diesel fuel and three pure HC compounds: 1-pentene, toluene, and iso-octane. The pure compound experiments confirmed the previous results regarding hydrocarbon reactivity: 1-pentene was the most efficient LNT reductant, followed by toluene. Injection location had minimal impact on the reactivity of these two compounds. Iso-octane was an ineffective LNT reductant, requiring high doses (resulting in high HC emissions) to achieve reasonable NOx conversions. Diesel fuel reactivity was sensitive to injection location, with the best performance achieved through fuel injection downstream of the DOC. This configuration generated large LNT temperature excursions, which probably improved the efficiency of the NOx storage/reduction process, but also resulted in very high HC emissions. The ORNL team demonstrated an LNT desulfation under 'road load' conditions using throttling, EGR, and in-pipe injection of diesel fuel. Flow reactor characterization of core samples cut from the front and rear of the engine-aged LNT revealed complex spatially dependent degradation mechanisms. The front of the catalyst contained residual sulfates, which impacted NOx storage and conversion efficiencies at high temperatures. The rear of the catalyst showed significant sintering of the washcoat and precious metal particles, resulting in lower NOx conversion efficiencies at low temperatures. Further flow reactor characterization of engine-aged LNT core samples established that low temperature performance was limited by slow release and reduction of stored NOx during regeneration. Carbon monoxide was only effective at regenerating the LNT at temperatures above 200 C; propene was unreactive even at 250 C. Low temperature operation also resulted in unselective NOx reduction, resulting in high emissions of both N{sub 2}O and NH{sub 3}. During the latter years of the CRADA, the focus was shifted from LNTs to other aftertreatment devices. Two years of the CRADA were spent developing detailed ammonia SCR device models with sufficient accuracy and computational efficiency to be used in development of model-based ammonia injection control algorithms.ORNL, working closely with partners at Navistar and Mi« less

Application of powder metallurgy techniques for the development of non-toxic ammunition. Final CRADA report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowden, R.; Kelly, R.

1997-05-30

The purpose of the Cooperative Research and Development Agreement (CRADA) between Martin Marietta Energy Systems, Inc., and Delta Frangible Ammunition (DFA), was to identify and evaluate composite materials for the development of small arms ammunition. Currently available small arms ammunition utilizes lead as the major component of the projectile. The introduction of lead into the environment by these projectiles when they are expended is a rapidly increasing environmental problem. At certain levels, lead is a toxic metal to the environment and a continual health and safety concern for firearm users as well as those who must conduct lead recovery operationsmore » from the environment. DFA is a leading supplier of high-density mixtures, which will be used to replace lead-based ammunition in specific applications. Current non-lead ammunition has several limitations that prevent it from replacing lead-based ammunition in many applications (such as applications that require ballistics, weapon recoil, and weapon function identical to that of lead-based ammunition). The purpose of the CRADA was to perform the research and development to identify cost-effective materials to be used in small arms ammunition that eventually will be used in commercially viable, environmentally conscious, non-lead, frangible and/or non-frangible, ammunition.« less

Final report for the Tera Computer TTI CRADA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davidson, G.S.; Pavlakos, C.; Silva, C.

1997-01-01

Tera Computer and Sandia National Laboratories have completed a CRADA, which examined the Tera Multi-Threaded Architecture (MTA) for use with large codes of importance to industry and DOE. The MTA is an innovative architecture that uses parallelism to mask latency between memories and processors. The physical implementation is a parallel computer with high cross-section bandwidth and GaAs processors designed by Tera, which support many small computation threads and fast, lightweight context switches between them. When any thread blocks while waiting for memory accesses to complete, another thread immediately begins execution so that high CPU utilization is maintained. The Tera MTAmore » parallel computer has a single, global address space, which is appealing when porting existing applications to a parallel computer. This ease of porting is further enabled by compiler technology that helps break computations into parallel threads. DOE and Sandia National Laboratories were interested in working with Tera to further develop this computing concept. While Tera Computer would continue the hardware development and compiler research, Sandia National Laboratories would work with Tera to ensure that their compilers worked well with important Sandia codes, most particularly CTH, a shock physics code used for weapon safety computations. In addition to that important code, Sandia National Laboratories would complete research on a robotic path planning code, SANDROS, which is important in manufacturing applications, and would evaluate the MTA performance on this code. Finally, Sandia would work directly with Tera to develop 3D visualization codes, which would be appropriate for use with the MTA. Each of these tasks has been completed to the extent possible, given that Tera has just completed the MTA hardware. All of the CRADA work had to be done on simulators.« less

The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population.

PubMed

Gamboa, Ricardo; Huesca-Gómez, Claudia; López-Pérez, Vanessa; Posadas-Sánchez, Rosalinda; Cardoso-Saldaña, Guillermo; Medina-Urrutia, Aida; Juárez-Rojas, Juan Gabriel; Soto, María Elena; Posadas-Romero, Carlos; Vargas-Alarcón, Gilberto

2018-05-21

We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors.

Value Proposition of Department of Defense Domestic Technology Transfer

DTIC Science & Technology

2010-01-15

Directorate NASA Langley Research Center and Boundary Layer Research, Inc., Everett, WA CRADA/PLA Complete Trivalent Chromium Pretreatment Naval Air...Dynamics Directorate NASA Langley Research Center and Boundary Layer Research, Inc., Everett, WA CRADA/PLA Trivalent Chromium Processes Naval Air...Warfare Systems Center, Pacific Various CRADA On-Hold Safety Welding Cart Air Force Training Device Design and Engineering Center Spika Welding

Development of a General-Purpose Analysis System Based on a Programmable Fluid Processor Final Report CRADA No. TC-2027-01

DOE Office of Scientific and Technical Information (OSTI.GOV)

McConaghy, C. F.; Gascoyne, P. R.

The purpose ofthis project was to develop a general-purpose analysis system based on a programmable fluid processor (PFP). The PFP is an array of electrodes surrounded by fluid reservoirs and injectors. Injected droplets of various reagents are manjpulated and combined on the array by Dielectrophoretic (DEP) forces. The goal was to create a small handheld device that could accomplish the tasks currently undertaken by much larger, time consuming, manual manipulation in the lab. The entire effo1t was funded by DARPA under the Bio-Flips program. MD Anderson Cancer Center was the PI for the DARPA effort. The Bio-Flips program was amore » 3- year program that ran from September 2000 to September 2003. The CRADA was somewhat behind the Bi-Flips program running from June 2001 to June 2004 with a no cost extension to September 2004.« less

Low Voltage Electron Beam Processing Final Report CRADA No. TC-645-93-A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, H.; Wakalopulos, G.

This CRADA project was established to develop a small, inexpensive sealed-tube electron beam processing system having immediate applications in industrial, high speed manufacturing processes, and in the Department of Energy (DOE) waste treatment/cleanup operations. The technical work involved the development and demonstration of a compact, sealed, 50-75 kilovolt (kV) EB generator prototype, including controls and power supply. The specific goals of this project were to develop a low cost vacuum tube capable of shooting an electron beam several inches into the air, and to demonstrate that wide area materials processing is feasible by stacking the tubes to produce continuous beams.more » During the project, we successfully demonstrated the producibility of a low cost electron beam system and several material processing operations of interest to US industry, DOE and, since September 11, 2001, the Homeland Security.« less

KSC-98pc376

NASA Image and Video Library

1998-03-18

KENNEDY SPACE CENTER, FLA. -- The alpha-magnetic spectrometer (AMS-1) is lifted in KSC’s MultiPayload Processing Facility in preparation for a move to the Space Station Processing Facility via the Payload Environmental Transportation System. The STS-91 payload arrived at KSC in January and is scheduled to be flown on the 9th and final Mir docking mission, scheduled for launch in May. The objectives of the AMS-1 investigation are to search for anti-matter and dark matter in space and to study astrophysics. The STS-91 flight crew includes Commander Charles Precourt; Pilot Dominic Gorie; and Mission Specialists Wendy B. Lawrence; Franklin Chang-Diaz, Ph.D.; Janet Kavandi, Ph.D.; and Valery Ryumin, with the Russian Space Agency. After docking with the Russian Space Station Mir, Mission Specialist Andrew Thomas, Ph.D., will join the STS-91 crew and return to Earth aboard Discovery

KSC-98pc375

NASA Image and Video Library

1998-03-18

KENNEDY SPACE CENTER, FLA. -- The alpha-magnetic spectrometer (AMS-1) is lifted in KSC’s MultiPayload Processing Facility in preparation for a move to the Space Station Processing Facility via the Payload Environmental Transportation System. The STS-91 payload arrived at KSC in January and is scheduled to be flown on the 9th and final Mir docking mission, scheduled for launch in May. The objectives of the AMS-1 investigation are to search for anti-matter and dark matter in space and to study astrophysics. The STS-91 flight crew includes Commander Charles Precourt; Pilot Dominic Gorie; and Mission Specialists Wendy B. Lawrence; Franklin Chang-Diaz, Ph.D.; Janet Kavandi, Ph.D.; and Valery Ryumin, with the Russian Space Agency. After docking with the Russian Space Station Mir, Mission Specialist Andrew Thomas, Ph.D., will join the STS-91 crew and return to Earth aboard Discovery

CRADAs: They're Not Just for NCI Anymore | Poster

Cancer.gov

By Karen Surabian, Thomas Stackhouse, and Jeffrey Thomas, Contributing Writers, and Bruce Crise, Guest Writer Advancing scientific discovery is increasingly dependent on diverse and innovative partnerships, and the Cooperative Research and Development Agreement (CRADA) is an essential tool for establishing partnerships. CRADAs allow a federal laboratory to enter into collaborative research and development (R&D) projects with outside parties (commercial or nonprofit).

New Aqueous Binders for Lithium-ion Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jansen, Andrew N.; Krumdick, Gregory K.; Trask, Stephen E.

2016-12-22

This final report summarizes the research effort of the CRADA between PPG Industries and Argonne National Laboratory (CRADA # C1400501 and Amendment 1 - ACK 85C11, Rev. 1), and completes the requirements of Task #5 in the CRADA. The results from Argonne represent a combined effort between the MERF and CAMP Facility (Materials Engineering Research Facility and the Cell Analysis, Modeling and Prototyping Facility). The key points of this report can be briefly summarized as: The multicomponent aqueous binder for NCM cathodes developed by PPG shows promising results when used on the CAMP Facility’s pilot-scale coater; NCM523 cathode electrodes exposedmore » to water exhibit a voltage anomaly in the first two formation cycles that appears to have little effect on the material capacity, but needs to be explored further; the experimental LFP electrode produced by PPG does cycle electrochemically, but with reduced capacity and an uncharacteristic voltage profile; there is no obvious correlation between the pH and zeta-potential of materials that are commonly used in the lithium-ion battery; lithium ions are more readily dissolved out of NCM523 by water than the transition metals (by two orders of magnitude), and suggests that the plating bath may need to be spiked with a lithium salt; the approach of creating sub-micron size NCM523 particles via ball milling results in a cathode material with poor electrochemical performance.« less

Sperm Scoring Using Multi-Spectral Flow Imaging and FISH-IS Final Report CRADA No. TC02088.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchetti, F.; Morrissey, P. J.

This was to be a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Amnis Corporation, to develop an automated system for scoring sperm interphase cells for the presence of chromosomal abnormalities using fluorescence in situ hybridization and the Amnis ImageStream technology platform.

Evaluation of SAGE Electrochromic Devices: Cooperative Research and Development Final Report, CRADA Number CRD-15-579

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tenent, Robert C.

2017-12-06

NREL will conduct durability testing of Sage Electrochromics dynamic windows products using American Society for Testing and Materials (ASTM) standard methods and drive parameters as defined by Sage. Window units will be tested and standard analysis performed. Data will be summarized and reported back to Sage at the end of the testing period.

Algorithms and Architectures for Elastic-Wave Inversion Final Report CRADA No. TC02144.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsen, S.; Lindtjorn, O.

2017-08-15

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Schlumberger Technology Corporation (STC), to perform a computational feasibility study that investigates hardware platforms and software algorithms applicable to STC for Reverse Time Migration (RTM) / Reverse Time Inversion (RTI) of 3-D seismic data.

The Google High Power Density Inverter Prize: Innovation in PV Inverter Power Density: Cooperative Research and Development Final Report, CRADA Number: CRD-14-568

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundstrom, Blake

Google is encouraging development of advanced photovoltaic inverters with high power density by holding a public competition and offering a prize for the best performing high power developed. NREL will perform the performance and validation for all inverters entered into the competition and provide results to Google.

Graded Reflectivity Mirror for the Solid State Heat Capacity Laser Final Report CRADA No. TC-2085-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamamoto, R.; Davis, J. A.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and the Boeing Company, to develop a Graded Reflectivity Mirror (GRM) to achieve improved near field fill and higher brightness in the far field output of LLNL’s Solid State Heat Capacity Laser (SSHCL).

Rarefaction Shock Wave Cutter for Offshore Oil-Gas Platform Removal Final Report CRADA No. TC02009.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glenn, L. A.; Barker, J.

This was a collaborative effort between Lawrence Livermore National Security, LLC/Lawrence Livermore National Laboratory (LLNL) (formerly the University of California) and Jet Research Center, a wholly owned division of Halliburton Energy Services, Inc. to design and prototype an improved explosive cutter for cutting the support legs of offshore oil and gas platforms.

Preoperative chemotherapy for T2 breast cancer is associated with improved surgical outcome.

PubMed

Karanlik, H; Ozgur, I; Cabioglu, N; Sen, F; Erturk, K; Kilic, B; Onder, S; Deniz, M; Yavuz, E; Aydiner, A

2015-09-01

The aim of this study is to compare the clinical outcome in T2 breast cancer patients who underwent preoperative chemotherapy (PC) and who did not. The study also tried to define a subgroup of patients, who are more beneficial after PC in terms of lower re-excision rates, better cosmetic results and local recurrence free survival. 251 consecutive patients treated for nonmetastatic T2 invasive breast cancer were analyzed retrospectively. Of those; 141 underwent primary surgery (PS) followed by chemotherapy, whereas 110 were treated with combination of PC and surgery. The patients who were treated with PC had a significantly higher incidence of negative margins and lower rate of re-excision (5% vs. 16%, p = 0.02). Of all patients attempted breast conserving surgery (BCS), patients in the PC group were more likely to undergo BCS as their definitive operation compared to patients with PS group (BCS rates; PC group: 99% vs. PS group: 92%, p = 0.05). Multifocal disease (OR: 7, 95% Cl, 2.7-18.4, p = 0.0001) and PC (OR = 0.2; 95% CI, 0.06-0.72, p = 0.01) were factors associated with margin positivity in patients treated with BCS. There was no statistically significant difference in 5 year local-recurrence free survival rates between 2 groups. Our study shows that PC significantly decreases the re-excision in patients undergoing BCS with primary T2 breast tumors. This data suggests that any patient with a tumor greater than 2 cm might be considered for PC to increase BCS success with final negative margins. Copyright © 2015. Published by Elsevier Ltd.

Information integrity and privacy for computerized medical patient records

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallegos, J.; Hamilton, V.; Gaylor, T.

Sandia National Laboratories and Oceania, Inc. entered into a Cooperative Research and Development Agreement (CRADA) in November 1993 to provide ``Information Integrity and Privacy for Computerized Medical Patient Records`` (CRADA No. SC93/01183). The main objective of the project was to develop information protection methods that are appropriate for databases of patient records in health information systems. This document describes the findings and alternative solutions that resulted from this CRADA.

KSC-98pc673

NASA Image and Video Library

1998-06-02

With the help of a suit technician, STS-91 Pilot Dominic L. Gorie dons his flight suit in the Operations and Checkout (O&C) Building prior to the crew walkout and transport to Launch Pad 39A. Gorie is on his first Shuttle mission. As a commander in the Navy, he flew combat missions in Operation Desert Storm and has earned a Distinguished Flying Cross as well as a master’s degree in aviation systems. Along with backing up Precourt on the flight deck, Gorie will perform the final Shuttle-Mir undocking and flyaround. He will also assist with the transfer of materials to and from Mir and the photographic documentation of the space station. STS91 is scheduled to be launched on June 2 with a launch window opening around 6:10 p.m. EDT. The mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will be returning to Earth as a STS-91 crew member after living more than four months aboard Mir

In-service testing of Ni{sub 3}Al coupons and trays in carburizing furnaces at Delphi Saginaw. CRADA final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sikka, V.K.; Santella, M.L.; Viswanathan, S.

1998-08-01

This Cooperative Research and Development Agreement (CRADA) report deals with the development of nickel aluminide alloy for improved longer life heat-resistant fixture assemblies for batch and continuous pusher carburizing furnaces. The nickel aluminide development was compared in both coupon and component testing with the currently used Fe-Ni-Cr heat-resisting alloy known as HU. The specific goals of the CRADA were: (1) casting process development, (2) characterization and possible modification of the alloy composition to optimize its manufacturing ability and performance under typical furnace operating conditions, and (3) testing and evaluation of specimens and prototype fixtures. In support of the CRADA objectives,more » coupons of nickel aluminide and the HU alloy were installed in both batch and pusher furnaces. The coupons were taken from two silicon levels and contained welds made with two different filler compositions (IC-221LA and IC-221W). Both nickel-aluminide and HU coupons were removed from the batch and pusher carburizing furnace at time intervals ranging from one month to one year. The exposed coupons were cut and mounted for metallographic, hardness, and microprobe analysis. The results of the microstructural analysis have been transmitted to General Motors Corporation, Saginaw Division (Delphi Saginaw) through reports that were presented at periodic CRADA review meetings. Based on coupon testing and verification of the coupon results with the testing of trays, Delphi Saginaw moved forward with the use of six additional trays in a batch furnace and two assemblies in a pusher furnace. Fifty percent of the trays and fixtures are in the as-cast condition and the remaining trays and fixtures are in the preoxidized condition. The successful operating experience of two assemblies in the pusher furnace for nearly a year formed the basis for a production run of 63 more assemblies. The production run required melting of 94 heats weighing 500 lb. each. Twenty-six of the 94 heats were from virgin stock, and 68 were from the revert that used 50% virgin and 50% revert. Detailed chemical analysis of the 94 heats reflected that the nickel aluminide can be cast into heat-treat fixtures under production conditions. In addition to the chemical analysis, the castings showed excellent dimensional reproducibility. A total of six batch furnace trays and 65 pusher furnace assemblies of nickel aluminide alloy IC-221M are currently operating in production furnaces at Delphi Saginaw. Two of the pusher furnace assemblies have completed two years of service without any failure. The CRADA has accomplished the goal of demonstrating that the nickel aluminide can be produced under commercial production conditions and it has superior performance over the currently used HU alloy in both batch and pusher furnaces.« less

Carbon recombination lines as a diagnostic of photodissociation regions

NASA Technical Reports Server (NTRS)

Natta, A.; Walmsley, C. M.; Tielens, A. G. G. M.

1994-01-01

We have observed the C91 alpha radio recombination line toward the Orion H II region. This narrow (approximately 3-5 km per sec full width at half maximum (FWHM)) line is spatially very extended (approximately 8 arcmin or 1 pc). These charateristics compare well with the observed characteristics of the C II fine structure line at 158 microns. Thus, the C91 alpha line originates in the predominantly neutral photodissociation regions separating the H II region from the molecular cloud. We have developed theoretical models for the C II radio recombination lines from photodissociation regions. The results show that the I(C91 alpha)/I(C158) intensity ratio is a sensitive function of the temperature and density of the emitting gas. We have also extended theoretical models for photodissociation regions to include the C II recombination lines. Comparison with these models show that, in the central portion of the Orion region, the C91 alpha line originates in dense (10(exp 6) per cu cm), warm (500-1000 K) gas. Even at large projected distances (approximately 1 pc), the inferred density is still high (10(exp 5) per cu cm) and implies extremely high thermal pressures. As in the case of the (C II) 158 microns line, the large extent of the C91 alpha line shows that (FUV) photons can penetrate to large distances from the illuminating source. The decline of the intensity of the incident radiation field with distance from Theta(sup 1) C seems to be dominated by geometrical dilution, rather than dust extinction. Finally, we have used our models to calculate the intensity of the 9850 A recombination line of C II. The physical conditions inferred from this line are in good agreement with those determined from the radio recombination and the far-infrared fine-structure lines. We show that the ratio of the 9850 A to the C91 alpha lines is a very good probe of very high density clumps.

Non-Invasive Pneumothorax Detector Final Report CRADA No. TC02110.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, J. T.; Purcell, R.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and ElectroSonics Medical Inc. (formerly known as BIOMEC, Inc.), to develop a non-invasive pneumothorax detector based upon the micropower impulse radar technology invented at LLNL. Under a Work for Others Subcontract (L-9248), LLNL and ElectroSonics successfully demonstrated the feasibility of a novel device for non-invasive detection of pneumothorax for emergency and long-term monitoring. The device is based on Micropower Impulse Radar (MIR) Ultra Wideband (UWB) technology. Phase I experimental results were promising, showing that a pneumothorax volume even asmore » small as 30 ml was clearly detectable from the MIR signals. Phase I results contributed to the award of a National Institute of Health (NIH) SBIR Phase II grant to support further research and development. The Phase II award led to the establishment of a LLNL/ElectroSonics CRADA related to Case No. TC02045.0. Under the subsequent CRADA, LLNL and ElectroSonics successfully demonstrated the feasibility of the pneumothorax detection in human subject research trials. Under this current CRADA TC02110.0, also referred to as Phase II Type II, the project scope consisted of seven tasks in Project Year 1; five tasks in Project Year 2; and four tasks in Project Year 3. Year 1 tasks were aimed toward the delivery of the pneumothorax detector design package for the pre-production of the miniaturized CompactFlash dockable version of the system. The tasks in Project Years 2 and 3 critically depended upon the accomplishments of Task 1. Since LLNL’s task was to provide subject matter expertise and performance verification, much of the timeline of engagement by the LLNL staff depended upon the overall project milestones as determined by the lead organization ElectroSonics. The scope of efforts were subsequently adjusted accordingly to commensurate with funding availability.« less

Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester.

PubMed

West, Allyson A; Yan, Jian; Jiang, Xinyin; Perry, Cydne A; Innis, Sheila M; Caudill, Marie A

2013-04-01

Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA). DHA plays a critical role in fetal development and is linked to health endpoints in adulthood. It is unknown whether choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or the PC:PE ratio in pregnant and nonpregnant women. This study tested whether choline intake affects indicators of choline-related lipid metabolism, including erythrocyte and plasma PC-DHA and PC:PE ratios, in pregnant women in the third trimester and nonpregnant women. Pregnant (n = 26) and nonpregnant (n = 21) women consumed 480 or 930 mg choline/d and a daily DHA supplement for 12 wk. Blood was collected at baseline and at the midpoint and end of the study. PC-DHA was analyzed as the proportion of total PC fatty acids. Pregnant women had greater (P = 0.002) PC-DHA concentrations than did nonpregnant women at baseline. The proportion of erythrocyte and plasma PC-DHA increased (P ≤ 0.002) in pregnant and nonpregnant women regardless of choline intake. However, in nonpregnant women, consumption of 930 mg choline/d led to greater (P < 0.001) erythrocyte PC-DHA and a more rapid increase (P < 0.001) in plasma PC-DHA. Lower (P = 0.001-0.024) erythrocyte and plasma PC:PE in pregnant women was not modified by choline intake. A higher choline intake may increase PEMT activity, resulting in greater PC-DHA enrichment of the PC molecule in nonpregnant women. Increased production of PC-DHA during pregnancy indicates elevated PEMT activity and a higher demand for methyl donors. This trial was registered at clinicaltrials.gov as NCT01127022.

Development of Plastic Substrate Technology for Active Matrix Liquid Crystal Displays Final Report CRADA No. TC-761-93

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carey, P.; Kamath, H.

Raychem Corporation (RYC) and the Lawrence Livermore National Laboratory (LLNL) conducted a development program with the goal to make rugged, low-cost., high-resolution flat panel displays based on RYC's proprietary Nematic Curvilinear Aligned Phase (NCAP) liquid crystal and LLNL's patented processes for the formation and doping of polycrystalline silicon on low-temperature, flexible, plastic substrates.

Winnebago Resource Study. Cooperative Research and Development Final Report, CRADA Number CRD-09-329

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jimenez, A.; Robichaud, R.

2015-03-01

Since 2005 the NREL Native American Tall Tower Loan program has assisted Native American tribes to assess their wind resource by lending tall (30m - 50m) anemometer. This program has allowed tribes a lower risk way to gather financeable wind data for potential utility scale wind energy projects. These projects offer Tribes a significant economic development opportunity.

Breast Cancer Diagnostic System Final Report CRADA No. TC02098.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubenchik, A. M.; DaSilva, L. B.

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Liver more National Laboratory (LLNL) and BioTelligent, Inc. together with a Russian Institution (BioFil, Ltd.), to develop a new system ( diagnostic device, operating procedures, algorithms and software) to accurately distinguish between benign and malignant breast tissue (Breast Cancer Diagnostic System, BCDS).

Renewable Energy Institute International (REII): Cooperative Research and Development Final Report, CRADA Number CRD-10-387

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carpenter, D.

2014-11-01

NREL will provide the Renewable Energy Institute with detailed on-site biomass gasifier syngas monitoring, using the NREL transportable Molecular Beam Mass Spectrometer. This information will be used to optimize the parameters of the gasifier operation, insuring the quality of the syngas made in the Red Lion Bioenergy gasifier and its compatibility with catalytic conversion to fuels.

Laser Shot Peening Final Report CRADA No. TC-02059-03

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stuart, B. C.; Hackel, L.

This was a collaborative effort between The Regents of the University of California, Lawrence Livermore National Laboratory (LLNL) and Metal Improvement Company, Inc. (MIC), to further develop the laser shot peening technology. This project had an emphasis on laser development and government and military applications including DOE’s natural gas and oil technology program (NGOTP), Yucca Mountain Project (YMP), F-22 Fighter, etc.

cCRADA | FNLCR Staging

Cancer.gov

A contractor Cooperative Research and Development Agreement(cCRADA) is a partnering mechanism that expands the opportunities for FNLCR’s researchers to work with external parties to conduct collaborative research activities and explore develo

Cargo Movement Operations System (CMOS). Final Software Design Document Increment III, (PC UNIX - Navy Configuration)

DTIC Science & Technology

1991-07-03

NO [ ] COMMENT DISPOSITION: COMMENT STATUS: OPEN [ ] CLOSED ( ] ORIGINATOR CONTROL NUMBER: SDD-0003 PROGRAM OFFICE CONTROL NUMBER: DATA ITEM DISCREPANCY WORKSHEET CDRL NUMBER: A006-02 DATE: 07/03/91 ORIGINATOR NAME: Vivian L. Martin OFFICE SYMBOL: SAIC TELEPHONE NUMBER: 272-2999 SUBSTANTIVE: X EDITORIAL: PAGE NUMBER: L-1 PARA NUMBER: 10 COMMENT OR RECOMMENDED CHANGE: Explain the effect of "no longer required" or "replaced" CSUs on the Navy configuration Menu hierarchy. RATIONALE: Paragraph 10 states that the CMOS menu heirarchy is

cCRADA | Frederick National Laboratory for Cancer Research

Cancer.gov

A contractor Cooperative Research and Development Agreement(cCRADA) is a partnering mechanism that expands the opportunities for Frederick National Laboratoryresearchers to work with external parties to conduct collaborative research acti

Atrial Model Development and Prototype Simulations: CRADA Final Report on Tasks 3 and 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Hara, T.; Zhang, X.; Villongco, C.

2016-10-28

The goal of this CRADA was to develop essential tools needed to simulate human atrial electrophysiology in 3-dimensions using an anatomical image-based anatomy and physiologically detailed human cellular model. The atria were modeled as anisotropic, representing the preferentially longitudinal electrical coupling between myocytes. Across the entire anatomy, cellular electrophysiology was heterogeneous, with left and right atrial myocytes defined differently. Left and right cell types for the “control” case of sinus rhythm (SR) was compared with remodeled electrophysiology and calcium cycling characteristics of chronic atrial fibrillation (cAF). The effects of Isoproterenol (ISO), a beta-adrenergic agonist that represents the functional consequences ofmore » PKA phosphorylation of various ion channels and transporters, was also simulated in SR and cAF to represent atrial activity under physical or emotional stress. Results and findings from Tasks 3 & 4 are described. Tasks 3 and 4 are, respectively: Input parameters prepared for a Cardioid simulation; Report including recommendations for additional scenario development and post-processing analytic strategy.« less

Predictive Model and Methodology for Heat Treatment Distortion Final Report CRADA No. TC-298-92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nikkel, D. J.; McCabe, J.

This project was a multi-lab, multi-partner CRADA involving LLNL, Los Alamos National Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, Martin Marietta Energy Systems and the industrial partner, The National Center of Manufacturing Sciences (NCMS). A number of member companies of NCMS participated including General Motors Corporation, Ford Motor Company, The Torrington Company, Gear Research, the Illinois Institute of Technology Research Institute, and Deformation Control Technology •. LLNL was the lead laboratory for metrology technology used for validation of the computational tool/methodology. LLNL was also the lead laboratory for the development of the software user interface , for the computationalmore » tool. This report focuses on the participation of LLNL and NCMS. The purpose of the project was to develop a computational tool/methodology that engineers would use to predict the effects of heat treatment on the _size and shape of industrial parts made of quench hardenable alloys. Initially, the target application of the tool was gears for automotive power trains.« less

Laser Materials Processing Final Report CRADA No. TC-1526-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crane, J.; Lehane, C. J.

2017-09-08

This CRADA project was a joint effort between Lawrence Livermore National Laboratory (LLNL) and United Technologies Corporation (UTC)/Pratt & Whitney (P&W) to demonstrate process capability for drilling holes in turbine airfoils using LLNL-developed femtosecond laser machining technology. The basis for this development was the ability of femtosecond lasers to drill precision holes in variety of materials with little or no collateral damage. The ultimate objective was to develop a laser machine tool consisting of an extremely advanced femtosecond laser subsystem to be developed by LLNL on a best-effort basis and a drilling station for turbine blades and vanes to bemore » developed by P&W. In addition, P&W was responsible for commercializing the system. The goal of the so called Advanced Laser Drilling (ALD) system was to drill specified complex hole-shapes in turbine blades and vanes with a high degree precision and repeatability and simultaneously capable of very high speed processing.« less

Airbags to Martian Landers: Analyses at Sandia National Laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gwinn, K.W.

1994-03-01

A new direction for the national laboratories is to assist US business with research and development, primarily through cooperative research and development agreements (CRADAs). Technology transfer to the private sector has been very successful as over 200 CRADAs are in place at Sandia. Because of these cooperative efforts, technology has evolved into some new areas not commonly associated with the former mission of the national laboratories. An example of this is the analysis of fabric structures. Explicit analyses and expertise in constructing parachutes led to the development of a next generation automobile airbag; which led to the construction, testing, andmore » analysis of the Jet Propulsion Laboratory Mars Environmental Survey Lander; and finally led to the development of CAD based custom garment designs using 3D scanned images of the human body. The structural analysis of these fabric structures is described as well as a more traditional example Sandia with the test/analysis correlation of the impact of a weapon container.« less

Development of a Delivery System for Treating Cerebrovascular Aneurysms Final Report CRADA No. TC-1440-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, A.; Derbin, J. T.

The objective of the project was to develop a system for delivering an implantable medical device used to treat cerebrovascular aneurysms, which can cause disability or hemorrhagic stroke (over 15,000 strokes in the U.S. each year are caused by ruptured aneurysms). Micrus has developed an implantable device with the potential to significantly improve the treatment of cerebrovascular aneurysms. This implantable device should significantly reduce the number of hemorrhagic strokes. LLNL has performed proof-of-concept experiments for a delivery system that could be modified to deploy the Micrus device into aneurysms. The purpose of this CRADA was to complete development of themore » LLNL delivery system and to integrate it with the Micrus device. The goal of the project was to develop an integrated minimally-invasive medical device for treating cerebrovascular aneurysms. The device was designed to access aneurysms through commercially-available catheters which are introduced into the patient through a small incision in the leg.« less

Hyperspectral Sensors Final Report CRADA No. TC02173.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Priest, R. E.; Sauvageau, J. E.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Science Applications International Corporation (SAIC), National Security Space Operations/SRBU, to develop longwave infrared (LWIR) hyperspectral imaging (HSI) sensors for airborne and potentially ground and space, platforms. LLNL has designed and developed LWIR HSI sensors since 1995. The current generation of these sensors has applications to users within the U.S. Department of Defense and the Intelligence Community. User needs are for multiple copies provided by commercial industry. To gain the most benefit from the U.S. Government’s prior investments inmore » LWIR HSI sensors developed at LLNL, transfer of technology and know-how from LLNL HSI experts to commercial industry was needed. The overarching purpose of the CRADA project was to facilitate the transfer of the necessary technology from LLNL to SAIC thereby allowing the U.S. Government to procure LWIR HSI sensors from this company.« less

Particulate Emissions Control using Advanced Filter Systems: Final Report for Argonne National Laboratory, Corning Inc. and Hyundai Motor Company CRADA Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seong, Hee Je; Choi, Seungmok

2015-10-09

This is a 3-way CRADA project working together with Corning, Inc. and Hyundai Motor Co. (HMC). The project is to understand particulate emissions from gasoline direct-injection engines (GDI) and their physico-chemical properties. In addition, this project focuses on providing fundamental information about filtration and regeneration mechanisms occurring in gasoline particulate filter (GPF) systems. For the work, Corning provides most advanced filter substrates for GPF applications and HMC provides three-way catalyst (TWC) coating services of these filter by way of a catalyst coating company. Then, Argonne National Laboratory characterizes fundamental behaviors of filtration and regeneration processes as well as evaluated TWCmore » functionality for the coated filters. To examine aging impacts on TWC and GPF performance, the research team evaluates gaseous and particulate emissions as well as back-pressure increase with ash loading by using an engine-oil injection system to accelerate ash loading in TWC-coated GPFs.« less

Brandon Research, Inc. Orthopedic Implant Cooperative Research and Development Agreement (CRADA) Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freeman, W.R.

1999-04-22

The project was a joint research effort between the U. S. Department of Energy's (DOE) Kansas City Plant (KCP) and Brandon Research, Inc. to develop ways to improve implants used for orthopedic surgery for joint replacement. The primary product produced by this study is design information, which may be used to develop implants that will improve long-term fixation and durability in the host bone environment.

Solidification Technologies for Radioactive and Chemical Liquid Waste Treatment - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castiglioni, Andrew J.; Gelis, Artem V.

This project, organized under DOE/NNSA's Global Initiatives for Proliferation Prevention program, joined Russian and DOE scientists in developing more effective solidification and storage technologies for liquid radioactive waste. Several patent applications were filed by the Russian scientists (Russia only) and in 2012, the technology developed was approved by Russia's Federal State Unitary Enterprise RADON for application throughout Russia in cleaning up and disposing of radioactive waste.

Research and Development of Zinc Air Fuel Cell To Achieve Commercialization Final Report CRADA No. TC-1544-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, J. F.; Haley, H. D.

The specific goal of this project was to advance the development of the zinc air fuel cell (ZAFC) towards commercial readiness in different mobile applications, including motor bikes, passenger cars, vans, buses and off-road vehicles (golf carts, factory equipment), and different stationary applications including generator sets, uninterruptible power systems and electric utility loading leveling and distributive power.

Command History OPNAV 5750-1, Fiscal Year 2004

DTIC Science & Technology

2006-05-04

Equipment allocation and distribution finalized. • 6-week plan developed for material production and testing. This project will have two primary...which has proven to be successful in the Navy’s past efforts to apply the proprietary technology to such materials as silicon- and carbon-based rubbers...and gels, epoxy resins, polyurethanes, etc. We will evaluate and select candidate materials and enlist the cooperation of suppliers and CRADA

Data Intensive Scientific Workflows on a Federated Cloud: CRADA Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garzoglio, Gabriele

The Fermilab Scientific Computing Division and the KISTI Global Science Experimental Data Hub Center have built a prototypical large-scale infrastructure to handle scientific workflows of stakeholders to run on multiple cloud resources. The demonstrations have been in the areas of (a) Data-Intensive Scientific Workflows on Federated Clouds, (b) Interoperability and Federation of Cloud Resources, and (c) Virtual Infrastructure Automation to enable On-Demand Services.

CRADA Payment Options | NCI Technology Transfer Center | TTC

Cancer.gov

NCI TTC CRADA PAYMENT OPTIONS: Electronic Payments by Wire Transfer via Fedwire, Mail a check to the Institute or Center, or Automated Clearing House (ACH)/Electronic Funds Transfer (ETF) payments via Pay.gov (NCI ONLY).

Palliative Care is Associated with Reduced Aggressive End-of-Life Care in Patients with Gastrointestinal Cancer.

PubMed

Merchant, Shaila J; Brogly, Susan B; Goldie, Craig; Booth, Christopher M; Nanji, Sulaiman; Patel, Sunil V; Lajkosz, Katherine; Baxter, Nancy N

2018-06-01

We examined the delivery of physician palliative care (PC) services and its association with aggressive end-of-life care (EOLC) in patients with gastrointestinal (GI) cancer in Ontario, Canada. All patients with primary cause of death from esophageal, gastric, colon, and anorectal cancer from January 2003 to December 2013 were identified. PC services within 2 years of death were classified: (1) any PC; (2) timing of first PC (≤ 7, 8-90, 91-180, and 181-730 days before death); and (3) intensity of PC measured by number of days used (1st-25th, 26th-50th, 51st-75th, and 76th-100th percentiles). Aggressive EOLC was defined as any of the following: chemotherapy, emergency department visits, hospital or intensive care unit (ICU) admissions (all ≤ 30 days of death), and death in hospital and in the ICU; these were combined as a composite outcome (any aggressive EOLC). The cohort included 34,630 patients, of whom 74% had at least one PC service. Timing of the first PC service varied: ≤ 7 (12%), 8-90 (42%), 91-180 (16%), and 181-730 (30%) days before death. Compared with patients not receiving PC, any PC was associated with a reduction in any aggressive EOLC (risk ratio [RR] 0.75, 95% confidence interval [CI] 0.74-0.76); this association was similar regardless of timing of the first PC service. The most dramatic reduction in aggressive EOLC occurred in patients who received the greatest number of days of PC (RR 0.65, 95% CI 0.63-0.67). The majority of patients received PC within 2 years of death. A larger number of days of PC was associated with a greater reduction in aggressive EOLC.

KSC-98pc676

NASA Image and Video Library

1998-06-02

STS-91 Mission Specialist Janet Lynn Kavandi gives a smile and a thumbs-up as two technicians help her with her flight suit in the Operations and Checkout (O&C) Building. The final fitting takes place prior to the crew walkout and transport to Launch Pad 39A. She is on her first Shuttle flight. Kavandi was selected as an astronaut candidate in 1994. She holds a doctorate in analytical chemistry and has received two patents. On this mission, she will be responsible for the SPACEHAB module aboard Discovery which will be used to transport supplies to Mir and bring back U.S. experiment hardware that has been in operation aboard the space station. She will also assist Chang-Diaz with AMS operations. STS-91 is scheduled to be launched on June 2 with a launch window opening around 6:10 p.m. EDT. The mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will return to Earth as a STS-91 crew member after living more than four months aboard Mir

Imaging Prostate Cancer Microenvironment by collagen Hybridization

DTIC Science & Technology

2014-10-01

from enlarged lymph nodes. Figure 3. Ex vivo NIRF imaging of PC-3 PIP xenograft. AI = androgen independent, AR = androgen receptor negative, PSMA ...center O.D. rim/focal ROI PC-3 rapid 0.25 ± .09 1.21 ± 0.40 PC-3 ( PSMA +) PIP rapid 0.26 ± .12 NA DU-145 slow 0.01 ± 0.01 0.06 ± 0.02 HP LNCaP

Control Strategies for HCCI Mixed-Mode Combustion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, Robert M; Edwards, Kevin Dean

2010-03-01

Delphi Automotive Systems and ORNL established this CRADA to expand the operational range of Homogenous Charge Compression Ignition (HCCI) mixed-mode combustion for gasoline en-gines. ORNL has extensive experience in the analysis, interpretation, and control of dynamic engine phenomena, and Delphi has extensive knowledge and experience in powertrain compo-nents and subsystems. The partnership of these knowledge bases was important to address criti-cal barriers associated with the realistic implementation of HCCI and enabling clean, efficient operation for the next generation of transportation engines. The foundation of this CRADA was established through the analysis of spark-assisted HCCI data from a single-cylinder research engine.more » This data was used to (1) establish a conceptual kinetic model to better understand and predict the development of combustion instabilities, (2) develop a low-order model framework suitable for real-time controls, and (3) provide guidance in the initial definition of engine valve strategies for achieving HCCI operation. The next phase focused on the development of a new combustion metric for real-time characterization of the combustion process. Rapid feedback on the state of the combustion process is critical to high-speed decision making for predictive control. Simultaneous to the modeling/analysis studies, Delphi was focused on the development of engine hardware and the engine management system. This included custom Delphi hardware and control systems allowing for flexible control of the valvetrain sys-tem to enable HCCI operation. The final phase of this CRADA included the demonstration of conventional and spark assisted HCCI on the multi-cylinder engine as well as the characterization of combustion instabilities, which govern the operational boundaries of this mode of combustion. ORNL and Delphi maintained strong collaboration throughout this project. Meetings were held on a bi-weekly basis with additional reports, presentation, and meetings as necessary to maintain progress. Delphi provided substantial support through modeling, hardware, data exchange, and technical consultation. This CRADA was also successful at establishing important next steps to further expanding the use of an HCCI engine for improved fuel efficiency and emissions. These topics will be address in a follow-on CRADA. The objectives are: (1) Improve fundamental understanding of the development of combustion instabilities with HCCI operation through modeling and experiments; (2) Develop low-order model and feedback combustion metrics which are well suited to real-time predictive controls; and (3) Construct multi-cylinder engine system with advanced Delphi technologies and charac-terize HCCI behavior to better understand limitations and opportunities for expanded high-efficiency operation.« less

Radiation Hardened Telerobotic Dismantling System Development Final Report CRADA No. TC-1340-96

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, C.; Lightman, A.

This project was a collaborative effort between the University of California, LLNL and RedZone Robotics, Inc. for the development of radiation-hardened telerobotic dismantling systems for use in applications such as nuclear facility remediation, nuclear accident response, and Chemobyltype remediation. The project supported the design, development, fabrication and testing of a Ukrainian robotic systems. The project was completed on time and within budget. All deliverables were completed. The final project deliverables were consistent with the plans developed in the original project with the exception that the fabricated systems remained in Ukraine.

How You Can Partner with NIH | NCI Technology Transfer Center | TTC

Cancer.gov

NCI Technology Transfer Center (TTC) provides an array of agreements to support the National Cancer Institute's partnering. Deciding which type of agreement to use can be a challenge: CRADA, MTA, collaboration, agreement, CTA, Materials-CRADA

Southern California Edison Grid Integration Evaluation: Cooperative Research and Development Final Report, CRADA Number CRD-10-376

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mather, Barry

2015-07-09

The objective of this project is to use field verification to improve DOE’s ability to model and understand the impacts of, as well as develop solutions for, high penetration PV deployments in electrical utility distribution systems. The Participant will work with NREL to assess the existing distribution system at SCE facilities and assess adding additional PV systems into the electric power system.

Medical Isotope Program: O-18, C-13, and Xe-129 Final Report CRADA No. TC-2043-02

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scheibner, K. F.; Fought, J.

This was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and Spectra Gases, Inc., to develop new and cheaper sources of Oxgyen-18 (O-18), Carbon-13 (C-13), and Xenon-129 (Xe-129), and to develop new applications of these stable medical isotopes in medicine resulting in a substantial increase in stable isotopes that are important to human health sciences.

Electron-Beam Vapor Deposition of Mold Inserts Final Report CRADA No. TSB-777-94

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shepp, T.; Feeley, T.

Lawrence Livermore National Laboratory and H.G.G. Laser Fare, Inc. studied the application of electron-beam vapor deposition technology to the production of mold inserts for use in an injection molding machine by Laser Fare. Laser Fare provided LLNL with the requirements of the mold inserts as well as sample inserts. LLNL replicated the mold insert(s) to Laser Fare for testing by Laser Fare.

Infrastructure, Components and System Level Testing and Analysis of Electric Vehicles: Cooperative Research and Development Final Report, CRADA Number CRD-09-353

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neubauer, J.

2013-05-01

Battery technology is critical for the development of innovative electric vehicle networks, which can enhance transportation sustainability and reduce dependence on petroleum. This cooperative research proposed by Better Place and NREL will focus on predicting the life-cycle economics of batteries, characterizing battery technologies under various operating and usage conditions, and designing optimal usage profiles for battery recharging and use.

Manufacturing Steps for Commercial Production of Nano-Structure Capacitors Final Report CRADA No. TC02159.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbee, T. W.; Schena, D.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and TroyCap LLC, to develop manufacturing steps for commercial production of nano-structure capacitors. The technical objective of this project was to demonstrate high deposition rates of selected dielectric materials which are 2 to 5 times larger than typical using current technology.

Digital X-Ray Imager Final Report CRADA No. TSB-1161-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Logan, C.; Toker, E.

The global objective of this cooperation was to lower the cost and improve the quality of breast health care in the United States. We planned to achieve it by designing a very high performance digital radiography unit for breast surgical specimen radiography in the operating room. These technical goals needed to be achieved at reasonable manufacturing costs to enable MedOptics to achieve high market penetration at a profit.

Metabolic system alterations in pancreatic cancer patient serum: potential for early detection

PubMed Central

2013-01-01

Background The prognosis of pancreatic cancer (PC) is one of the poorest among all cancers, due largely to the lack of methods for screening and early detection. New biomarkers for identifying high-risk or early-stage subjects could significantly impact PC mortality. The goal of this study was to find metabolic biomarkers associated with PC by using a comprehensive metabolomics technology to compare serum profiles of PC patients to healthy control subjects. Methods A non-targeted metabolomics approach based on high-resolution, flow-injection Fourier transform ion cyclotron resonance mass spectrometry (FI-FTICR-MS) was used to generate comprehensive metabolomic profiles containing 2478 accurate mass measurements from the serum of Japanese PC patients (n=40) and disease-free subjects (n=50). Targeted flow-injection tandem mass spectrometry (FI-MS/MS) assays for specific metabolic systems were developed and used to validate the FI-FTICR-MS results. A FI-MS/MS assay for the most discriminating metabolite discovered by FI-FTICR-MS (PC-594) was further validated in two USA Caucasian populations; one comprised 14 PCs, six intraductal papillary mucinous neoplasims (IPMN) and 40 controls, and a second comprised 1000 reference subjects aged 30 to 80, which was used to create a distribution of PC-594 levels among the general population. Results FI-FTICR-MS metabolomic analysis showed significant reductions in the serum levels of metabolites belonging to five systems in PC patients compared to controls (all p<0.000025). The metabolic systems included 36-carbon ultra long-chain fatty acids, multiple choline-related systems including phosphatidylcholines, lysophosphatidylcholines and sphingomyelins, as well as vinyl ether-containing plasmalogen ethanolamines. ROC-AUCs based on FI-MS/MS of selected markers from each system ranged between 0.93 ±0.03 and 0.97 ±0.02. No significant correlations between any of the systems and disease-stage, gender, or treatment were observed. Biomarker PC-594 (an ultra long-chain fatty acid), was further validated using an independently-collected US Caucasian population (blinded analysis, n=60, p=9.9E-14, AUC=0.97 ±0.02). PC-594 levels across 1000 reference subjects showed an inverse correlation with age, resulting in a drop in the AUC from 0.99 ±0.01 to 0.90 ±0.02 for subjects aged 30 to 80, respectively. A PC-594 test positivity rate of 5.0% in low-risk reference subjects resulted in a PC sensitivity of 87% and a significant improvement in net clinical benefit based on decision curve analysis. Conclusions The serum metabolome of PC patients is significantly altered. The utility of serum metabolite biomarkers, particularly PC-594, for identifying subjects with elevated risk of PC should be further investigated. PMID:24024929

Clinical Trials Reference Materials and Related Links | Division of Cancer Prevention

Cancer.gov

Agreements Clinical Trials Agreement Confidential Disclosure Agreements Cooperative Research and Development Agreement (CRADA) - Research Plan Financial and Staffing Contribution of the Parties Exception or Modifications to the CRADA Human Subject Protection/Informed Consent Tutorials (or Education) |

Extraction of Iodine from Source Rock and Oil for Radioiodine Dating Final Report CRADA No. TC-1550-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moran, J. E.; Summa, L.

This was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and Exxon Production Research Company (EPR) to develop improved techniques for extracting, concentrating, and measuring iodine from large volumes of source rock and oil. The purpose of this project was to develop a technique for measuring total iodine extracted from rock, obtain isotopic ratios, and develop age models for samples provided by EPR.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tiegs, T.N.

The Cooperative Research and Development Agreement (CRADA) was to develop composites of TiC-Ni{sub 3}Al with refined grain microstructures for application in diesel engine fuel injection devices. Grain refinement is important for improved wear resistance and high strength for the applications of interest. Attrition milling effectively reduces the initial particle size and leads to a reduction of the final grain size. However, an increase in the oxygen content occurs concomitantly with the grinding operation and decreased densification of the compacts occurs during sintering.

The role of peri-hepatic drain placement in liver surgery: a prospective analysis

PubMed Central

Butte, Jean M; Grendar, Jan; Bathe, Oliver; Sutherland, Francis; Grondin, Sean; Ball, Chad G; Dixon, Elijah

2014-01-01

Background The standard use of an intra-operative perihepatic drain (IPD) in liver surgery is controversial and mainly supported by retrospective data. The aim of this study was to evaluate the role of IPD in liver surgery. Methods All patients included in a previous, randomized trial were analysed to determine the association between IPD placement, post-operative complications (PC) and treatment. A multivariate analysis identified predictive factors of PC. Results One hundred and ninety-nine patients were included in the final analysis of which 114 (57%) had colorectal liver metastases. IPD (n = 87, 44%) was associated with pre-operative biliary instrumentation (P = 0.023), intra-operative bleeding (P < 0.011), Pringle’s manoeuver(P < 0.001) and extent of resection (P = 0.001). Seventy-seven (39%) patients had a PC, which was associated with pre-operative biliary instrumentation (P = 0.048), extent of resection (P = 0.002) and a blood transfusion (P = 0.001). Patients with IPD had a higher rate of high-grade PC (25% versus 12%, P = 0.008). Nineteen patients (9.5%) developed a post-operative collection [IPD (n = 10, 11.5%) vs. no drains (n = 9, 8%), P = 0.470]. Seven (8%) patients treated with and 9(8%) without a IPD needed a second drain after surgery, P = 1. Resection of ≥3 segments was the only independent factor associated with PC [odds ratio (OR) = 2, P = 0.025, 95% confidence interval (CI) 1.1–3.7]. Discussion In spite of preferential IPD use in patients with more complex tumours/resections, IPD did not decrease the rate of PC, collections and the need for a percutaneous post-operative drain. IPD should be reserved for exceptional circumstances in liver surgery. PMID:25041265

Development of HANAA to Achieve Commercialization Final Report CRADA No. TC-2025-01

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koopman, R. P.; Schmidt, J. C.

The objective of this project was to provide DOD and the intelligence agencies with highly portable, advanced, bio-detection instruments and to further the DOE objective of putting advanced instrumentation for the detection of biological terrorism agents into the hands of first responders. All sponsors of the HANAA development work at LLNL believed that the technology must be commercialized to fully contribute to their missions. Intelligence organizations, military teams, and first responders must be able to purchase the instruments for a reasonable price and obtain maintenance services and support equipment from a reliable supplier in order for the instrument to bemore » useful to them. The goal was to efficiently transfer HANAA technology from LLNL to ETG, a company that would manufacture the instrument and make it commercially available to the constituencies important to our sponsors. This was to include a current beta test instrument and all knowledge of problems with the instrument and recommendations for solving those problems in a commercial version. The following tasks were to be completed under this CRADA.« less

Development of a High Volume Capable Process to Manufacture High Performance Photovoltaic Cells: Cooperative Research and Development Final Report, CRADA Number CRD-08-322

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geisz, J. F.

2012-11-01

The intent of the work is for RFMD and NREL to cooperate in the development of a commercially viable and high volume capable process to manufacture high performance photovoltaic cells, based on inverted metamorphic (IMM) GaAs technology. The successful execution of the agreement will result in the production of a PV cell using technology that is capable of conversion efficiency at par with the market at the time of release (reference 2009: 37-38%), using RFMD's production facilities. The CRADA work has been divided into three phases: (1) a foundation phase where the teams will demonstrate the manufacturing of a basicmore » PV cell at RFMD's production facilities; (2) a technology demonstration phase where the teams will demonstrate the manufacturing of prototype PV cells using IMM technology at RFMD's production facilities, and; (3) a production readiness phase where the teams will demonstrate the capability to manufacture PV cells using IMM technology with high yields, high reliability, high reproducibility and low cost.« less

Advanced High Power mm-Wave Microwave Devices Final Report CRADA No. TC-0287-92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shang, C. C.; Tomlin, T.

The purpose of this CRADA was to improve existing high-average-power microwave devices and develop the next generation microwave devices for energy and defense applications. A Free Electron Maser was under test at the FOM Institute (Rijnhuizen) Netherlands with the goal of producing a lMW-long pulse to CW microwave output in the range 130GHz to 250GHz. The DC acceleration and beam transport system is eventually to be used in a depressed collector cotilguration requiring 99.8% beam transmission in order that the high voltage 2MV supply be required only to supply 20 milliamps of body current. A relativistic version of the Herrmannmore » optical theory originally developed for microwave tube beams was used to take into account thermal elections far out on the gaussian distribution tail that can translate into beam current well outside the ideal beam edge. This theory was applied to the FOM beamline design and predicts that the beam envelope containing 99.8% of the current can be successfully transported to the undulator for a wide range of assumed eminence values.« less

Concepts for the Design of a Diagnostic Device to Detect Malignancies in Human Tissues Final Report CRADA No. TSB-2023-00

DOE Office of Scientific and Technical Information (OSTI.GOV)

DaSilva, L.; Marion, J.; Chase, C.

BioLuminate, Inc. planned to develop, produce and market a revolutionary diagnostic device for early breast cancer diagnosis. The device was originally invented by NASA; and exclusively licensed to BioLuminate for commercialization. At the time of the CRADA, eighty-five percent (85%) of all biopsies in the United States were found negative each year. The number of biopsies cost the health care system $23 billio n annually. A multi-sensor probe would allow surgeons to improve breast cancer scre ening and significantly reduce the number of biopsies. BioLuminate was developing an in-vivo system for the detection of cancer using a multi-sensor needle/probe. Themore » first system would be developed for the detection of breast cancer. LLNL, in collaboration with BioLuminate worked toward a detailed concept specification for the prototype multi-sensor needle/probe suitable for breast cancer analysis. BioLuminate in collaboration with LLNL, worked to develop a new version of the needle probe that would be the same size as needles commonly used to draw blood.« less

National Security Science and Technology Initiative: Air Cargo Screening, Final Report for CRADA Number NFE-07-01081

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bingham, Philip; Bush, John; Bowerman, Biays

The non-intrusive inspection (NII) of consolidated air cargo carried on commercial passenger aircraft continues to be a technically challenging, high-priority requirement of the Department of Homeland Security’s Science and Technology Directorate (DHS S&T), the Transportation Security Agency and the Federal Aviation Administration. The goal of deploying a screening system that can reliably and cost-effectively detect explosive threats in consolidated cargo without adversely affecting the flow of commerce will require significant technical advances that will take years to develop. To address this critical National Security need, the Battelle Memorial Institute (Battelle), under a Cooperative Research and Development Agreement (CRADA) with fourmore » of its associated US Department of Energy (DOE) National Laboratories (Oak Ridge, Pacific Northwest, Idaho, and Brookhaven), conducted a research and development initiative focused on identifying, evaluating, and integrating technologies for screening consolidated air cargo for the presence of explosive threats. Battelle invested $8.5M of internal research and development funds during fiscal years 2007 through 2009.« less

Improving Translation Models for Predicting the Energy Yield of Photovoltaic Power Systems. Cooperative Research and Development Final Report, CRADA Number CRD-13-526

DOE Office of Scientific and Technical Information (OSTI.GOV)

Emery, Keith

2015-08-04

The project under this CRADA will analyze field data of various flat-plate and concentrator module technologies and cell measurements at the laboratory level. The field data will consist of current versus voltage data collected over many years on a latitude tilt test bed for Si, CdTe, amorphous silicon, and CIGS technologies. The concentrator data will be for mirror- and lens-based module designs using multijunction cells. The laboratory data will come from new measurements of cell performance with systematic variation of irradiance, temperature and spectral composition. These measurements will be labor-intensive and the aim will be to cover the widest possiblemore » parameter space for as many different PV samples as possible. The data analysis will require software tools to be developed. These tools will be customized for use with the specific NREL datasets and will be unsuitable for commercial release. The tools will be used to evaluate different translation equations against NREL outdoor datasets.« less

KSC-98pc732

NASA Image and Video Library

1998-06-02

KENNEDY SPACE CENTER, Fla. -- Startled by the thunderous roar of the Space Shuttle Discovery’s engines as it lifts off, birds hurriedly leave the Launch Pad 39A area for a more peaceful site. Liftoff time for the 91st Shuttle launch and last Shuttle-Mir mission was 6:06:24 p.m. EDT June 2. On board Discovery are Mission Commander Charles J. Precourt; Pilot Dominic L. Gorie; and Mission Specialists Wendy B. Lawrence, Franklin R. Chang-Diaz, Janet Lynn Kavandi and Valery Victorovitch Ryumin. The nearly 10-day mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for the Space Shuttle orbiter Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will be returning to Earth as an STS-91 crew member after living more than four months aboard Mir

Epileptic Seizure Forewarning by Nonlinear Techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hively, L.M.

2002-04-19

This report describes work that was performed under a Cooperative Research and Development Agreement (CRADA) between UT-Battelle, LLC (Contractor) and a commercial participant, VIASYS Healthcare Inc. (formerly Nicolet Biomedical, Inc.). The Contractor has patented technology that forewarns of impending epileptic events via scalp electroencephalograph (EEG) data and successfully demonstrated this technology on 20 datasets from the Participant under pre-CRADA effort. This CRADA sought to bridge the gap between the Contractor's existing research-class software and a prototype medical device for subsequent commercialization by the Participant. The objectives of this CRADA were (1) development of a combination of existing computer hardware andmore » Contractor-patented software into a clinical process for warning of impending epileptic events in human patients, and (2) validation of the epilepsy warning methodology. This work modified the ORNL research-class FORTRAN for forewarning to run under a graphical user interface (GUI). The GUI-FORTRAN software subsequently was installed on desktop computers at five epilepsy monitoring units. The forewarning prototypes have run for more than one year without any hardware or software failures. This work also reported extensive analysis of model and EEG datasets to demonstrate the usefulness of the methodology. However, the Participant recently chose to stop work on the CRADA, due to a change in business priorities. Much work remains to convert the technology into a commercial clinical or ambulatory device for patient use, as discussed in App. H.« less

78 FR 42532 - Cooperative Research and Development Agreement (CRADA) Opportunity With the Department of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-16

... DEPARTMENT OF HOMELAND SECURITY Cooperative Research and Development Agreement (CRADA) Opportunity With the Department of Homeland Security for the Development of a Foot-and-Mouth Disease 3ABC ELISA... in developing and validating an ELISA diagnostic kit for detection of Foot and Mouth Disease Virus...

Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)*

PubMed Central

Haas, Laura T.; Kostylev, Mikhail A.; Strittmatter, Stephen M.

2014-01-01

Soluble Amyloid-β oligomers (Aβo) can trigger Alzheimer disease (AD) pathophysiology by binding to cell surface cellular prion protein (PrPC). PrPC interacts physically with metabotropic glutamate receptor 5 (mGluR5), and this interaction controls the transmission of neurotoxic signals to intracellular substrates. Because the interruption of the signal transduction from PrPC to mGluR5 has therapeutic potential for AD, we developed assays to explore the effect of endogenous ligands, agonists/antagonists, and antibodies on the interaction between PrPC and mGluR5 in cell lines and mouse brain. We show that the PrPC segment of amino acids 91–153 mediates the interaction with mGluR5. Agonists of mGluR5 increase the mGluR5-PrPC interaction, whereas mGluR5 antagonists suppress protein association. Synthetic Aβo promotes the protein interaction in mouse brain and transfected HEK-293 cell membrane preparations. The interaction of PrPC and mGluR5 is enhanced dramatically in the brains of familial AD transgenic model mice. In brain homogenates with Aβo, the interaction of PrPC and mGluR5 is reversed by mGluR5-directed antagonists or antibodies directed against the PrPC segment of amino acids 91–153. Silent allosteric modulators of mGluR5 do not alter Glu or basal mGluR5 activity, but they disrupt the Aβo-induced interaction of mGluR5 with PrPC. The assays described here have the potential to identify and develop new compounds that inhibit the interaction of PrPC and mGluR5, which plays a pivotal role in the pathogenesis of Alzheimer disease by transmitting the signal from extracellular Aβo into the cytosol. PMID:25148681

Reconciling Basin-Scale Top-Down and Bottom-Up Methane Emission Measurements for Onshore Oil and Gas Development: Cooperative Research and Development Final Report, CRADA Number CRD-14-572

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heath, Garvin A.

The overall objective of the Research Partnership to Secure Energy for America (RPSEA)-funded research project is to develop independent estimates of methane emissions using top-down and bottom-up measurement approaches and then to compare the estimates, including consideration of uncertainty. Such approaches will be applied at two scales: basin and facility. At facility scale, multiple methods will be used to measure methane emissions of the whole facility (controlled dual tracer and single tracer releases, aircraft-based mass balance and Gaussian back-trajectory), which are considered top-down approaches. The bottom-up approach will sum emissions from identified point sources measured using appropriate source-level measurement techniquesmore » (e.g., high-flow meters). At basin scale, the top-down estimate will come from boundary layer airborne measurements upwind and downwind of the basin, using a regional mass balance model plus approaches to separate atmospheric methane emissions attributed to the oil and gas sector. The bottom-up estimate will result from statistical modeling (also known as scaling up) of measurements made at selected facilities, with gaps filled through measurements and other estimates based on other studies. The relative comparison of the bottom-up and top-down estimates made at both scales will help improve understanding of the accuracy of the tested measurement and modeling approaches. The subject of this CRADA is NREL's contribution to the overall project. This project resulted from winning a competitive solicitation no. RPSEA RFP2012UN001, proposal no. 12122-95, which is the basis for the overall project. This Joint Work Statement (JWS) details the contributions of NREL and Colorado School of Mines (CSM) in performance of the CRADA effort.« less

Electrical Microengineering of Redox Enzymes

DTIC Science & Technology

1994-03-31

coating applied to the electrode 41 to prevent lose of mediator graphite foil potassium -~0.02a 0.03  electrolyte wus dioxane with 15% 42...hexacyanoferrats(ll)d aqueous buffer carbon fiber’ none h 40-5000 biotin/avidin complex used to obtain a 43 surface layer of HRP Pt organic metal, potassium ...OFFICE OF NAVAL RESEARCH AD-A279 015 FINAL REPORT FOR CONTRACT NOOO 14-91 -J- 1656 R&T CODE 413h007---05 ELECTRICAL MICROENGINEERING OF REDOX ENZYMES

Accelerator-Detector Complex for Photonuclear Detection of Hidden Explosives Final Report CRADA No. TC2065.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowdermilk, W. H.; Brothers, L. J.

This was a collaborative effort by Lawrence Livermore National Security (formerly the University of California)/Lawrence Livermore National Laboratory (LLNL), Valley Forge Composite Technologies, Inc., and the following Russian Institutes: P. N. Lebedev Physical Institute (LPI), Innovative Technologies Center.(AUO CIT), Central Design Bureau-Almas (CDB Almaz), Moscow Instrument Automation Research Institute, and Institute for High Energy Physics (IBEP) to develop equipment and procedures for detecting explosive materials concealed in airline checked baggage and cargo.

Public Key-Based Need-to-Know Authorization Engine Final Report CRADA No. TSB-1553-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mark, R.; Williams, R.

The goals of this project were to develop a public key-based authentication service plug-in based on LLNL's requirements, integrate the public key-based authentication with the Intra Verse authorization service adn the LLNL NTK server by developing a full-featured version of the prototyped Intra Verse need-to-know plug in; and to test the authorization and need-to-know plug-in in a secured extranet prototype among selected national Labs.

Exploration of Novel Materials for Development of Next Generation OPV Devices: Cooperative Research and Development Final Report, CRADA Number CRD-10-398

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olson, D.

2012-09-01

Organic-based solar cells offer the potential for low cost, scalable conversion of solar energy. This project will try to utilize the extensive organic synthetic capabilities of ConocoPhillips to produce novel acceptor and donor materials as well potentially as interface modifiers to produce improved OPV devices with greater efficiency and stability. The synthetic effort will be based on the knowledge base and modeling being done at NREL to identify new candidate materials.

Reliability Evaluation of Next Generation Inverter: Cooperative Research and Development Final Report, CRADA Number CRD-12-478

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paret, Paul

The National Renewable Energy Laboratory (NREL) will conduct thermal and reliability modeling on three sets of power modules for the development of a next generation inverter for electric traction drive vehicles. These modules will be chosen by General Motors (GM) to represent three distinct technological approaches to inverter power module packaging. Likely failure mechanisms will be identified in each package and a physics-of-failure-based reliability assessment will be conducted.

High-speed microprocessor characterization. Final report/project accomplishments summary, CRADA Number KCP-94-1004

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, L.W.

The objective of the project was to characterize and document the critical operating parameters of an 0.8-micron, 350-MHz, 32-bit microprocessor prototype. The roles of FM and T and the participant company were: FM and T -- evaluation performance of the prototype 32-bit microprocessor using the IDS5000 and Tektronix S3260 Integrated Circuit Test System; Corda -- design and build the prototype microprocessor. This project was terminated with nearly all of the planned activities unaddressed.

Xylo-Oligosaccharide Process Development, Composition, and Techno-Economic Analysis. Cooperative Research and Development Final Report, CRADA Number CRD-12-483

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shekiro, Joe; Elander, Richard

2015-12-01

The purpose of this cooperative work agreement between General Mills Inc. (GMI) and NREL is to determine the feasibility of producing a valuable food ingredient (xylo-oligosaccharides or XOS), a highly soluble fiber material, from agricultural waste streams, at an advantaged cost level relative to similar existing ingredients. The scope of the project includes pilot-scale process development (Task 1), compositional analysis (Task 2), and techno-economic analysis (Task 3).

Solar Technology Validation Project - USS Data, LLC: Cooperative Research and Development Final Report, CRADA Number CRD-09-367-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilcox, S.

2013-08-01

Under this Agreement, NREL will work with Participant to improve concentrating solar power system performance characterizations. This work includes, but is not limited to, research and development of methods for acquiring renewable resource characterization information using site-specific measurements of solar radiation and meteorological conditions; collecting system performance data; and developing tools for improving the design, installation, operation, and maintenance of solar energy conversion systems. This work will be conducted at NREL and Participant facilities.

Solar Technology Validation Project - RES Americas: Cooperative Research and Development Final Report, CRADA Number CRD-09-367-11

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilcox, S.

Under this Agreement, NREL will work with Participant to improve concentrating solar power system performance characterizations. This work includes, but is not limited to, research and development of methods for acquiring renewable resource characterization information using site-specific measurements of solar radiation and meteorological conditions; collecting system performance data; and developing tools for improving the design, installation, operation, and maintenance of solar energy conversion systems. This work will be conducted at NREL and Participant facilities.

Rapidly Deployable Security System Final Report CRADA No. TC-2030-01

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kohlhepp, V.; Whiteman, B.; McKibben, M. T.

The ultimate objective of the LEADER and LLNL strategic partnership was to develop and commercialize_a security-based system product and platform for the use in protecting the substantial physical and economic assets of the government and commerce of the United States. The primary goal of this project was to integrate video surveillance hardware developed by LLNL with a security software backbone developed by LEADER. Upon completion of the project, a prototype hardware/software security system that is highly scalable was to be demonstrated.

Development and Implementaton of Advanced Materials for Aircraft Engine Applications Development and Implementation of Nanostructure Laminates Final Report CRADA No. TC-0497-93-B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbee, T. W.; Yee, W.

The objective of this project was to develop engineered nanostructure laminate materials for applications in gas turbine engines. Although the focus of this effort was on developing improved · thermal barrier coatings, the data and experience gained through such project tasks as basic theoretical work and modeling of composition/structure property relationships can be applied. to the development of microscructure laminates for other·applications.

77 FR 1708 - Cooperative Research and Development Agreement: Technology To Provide Wireless Precise Time...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-11

... determine the viability of certain wireless alternative timing approaches by conducting live, on-air tests... conducted from other sites as deemed necessary during CRADA testing. Reception of these test broadcasts are..., Test Plan, and Project Report for each phase of the CRADA work. We anticipate that the non-Federal...

78 FR 50424 - NIH Cooperative Research and Development Agreement Program: Invitation To Solicit Nonclinical and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

...) Program. This CRADA Program is an extension of collaboration opportunities solicited by NIH or developed... health mission of the NIH. These collaboration opportunities are structured under the authority of 15 U.S... use of such additional information. The collaboration will be governed by CRADA terms that address...

76 FR 25362 - Cooperative Research and Development Agreement: Butanol Fuel Blend Usage With Marine Outboard...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-04

... participants would identify and investigate the advantages, disadvantages, required technology enhancements... Development Agreements (CRADAs), are authorized by the Federal Technology Transfer Act of 1986 (Pub. L. 99- 502, codified at 15 U.S.C. 3710(a)). A CRADA promotes the transfer of technology to the private sector...

CRADA opportunities in pressurized combustion research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maloney, D J; Norton, T S; Casleton, K H

1995-06-01

The Morgantown Energy Technology Center recently began operation of a Low Emissions Combustor Test and Research (LECTR) Facility. This facility was built to support the development of Advanced Gas Turbine Systems (ATS) by providing test facilities and engineering support to METC customers through the ATS University-Industry Consortium and through CRADA participation with industrial partners.

Effects of feeding ractopamine hydrochloride (Paylean) to physical and immunological castrates (Improvest) in a commercial setting on carcass cutting yields and loin quality.

PubMed

Lowe, B K; Gerlemann, G D; Carr, S N; Rincker, P J; Schroeder, A L; Petry, D B; McKeith, F K; Allee, G L; Dilger, A C

2014-08-01

Effects of feeding ractopamine (RAC; 5 mg/kg) to physically castrated (PC) and immunologically castrated (IC) pigs on carcass characteristics, cutting yields, and loin quality were evaluated using 285 carcasses. Male pigs were randomly assigned to sex treatments (PC and IC) at birth and fed the same nursery diets before allotment into 32 pens with 22 pigs per pen in a grow-finish barn. Pigs in the PC group were physically castrated at approximately 5 d of age, and pigs in the IC group were administered Improvest at 11 and 18 wk of age. Diet treatments (control or RAC) were initiated on study d 87. Pigs were marketed at 12 d (4.5 wk post-second Improvest dose), 19 d (5.5 wk post-second Improvest dose), and 33 d (7.5 wk post-second Improvest dose) following the start of final diet treatments. Three carcasses per pen were selected for evaluation of cutting yields and loin quality. Data were analyzed using PROC MIXED in SAS with fixed effects of sex, diet, market group, and their interaction; carcass (N = 285) was the experimental unit. Carcasses from RAC-fed pigs were heavier (P < 0.01) and had deeper (P = 0.02) loins than control-fed carcasses. Carcasses from IC pigs were similar (P = 0.22) in weight but had less (P < 0.01) fat and shallower (P = 0.02) loins when compared to PC carcasses. There were differences (P < 0.05) among market groups for carcass weights, fat depths, loin depths, and estimated carcass leanness. For cutting yields, RAC-fed carcasses had greater (P ≤ 0.03) bone-in lean and total carcass cutting yields than control-fed carcasses while there were no differences (P > 0.05) between RAC-fed and control-fed carcasses when evaluating LM color, marbling, firmness, pH, drip loss, and tenderness. Carcasses from IC pigs had greater (P < 0.05) boneless lean yields, bone-in lean yields, and total carcass cutting yields than PC carcasses. There were minimal differences (P < 0.05) in LM marbling, firmness, composition, and tenderness between PC and IC pigs. There was an interaction (P = 0.03) between sex and diet for LM composition. Control-fed PC loins had more (P < 0.01) lipid than all other treatment combinations. Market group had effects (P < 0.05) on carcass cutting yields, LM color, marbling and firmness scores, pH, purge loss, composition, and tenderness. The results from this study indicated RAC and immunological castration were additive in terms of improving carcass cutting yields while having minimal effects on pork quality.

Tire Development for Effective Transportation and Utilization of Used Tires, CRADA 01-N044, Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Susan M. Maley

Scrap tires represent a significant disposal and recycling challenge for the United States. Over 280 million tires are generated on an annual basis, and several states have large stockpiles or abandoned tire piles that are slated for remediation. While most states have programs to address the accumulation and generation of scrap tires, most of these states struggle with creating and sustaining recycling or beneficial end use markets. One of the major issues with market development has been the costs associated with transporting and processing the tires into material for recycling or disposal. According to a report by the Rubber Manufacturesmore » Association tire-derived fuel (TDF) represents the largest market for scrap tires, and approximately 115 million tires were consumed in 2001 as TDF (U.S. Scrap Tire Markets, 2001, December 2002, www.rma.org/scraptires). This market is supported primarily by cement kilns, followed by various industries including companies that operate utility and industrial boilers. However the use of TDF has not increased and the amount of TDF used by boiler operators has declined. The work completed through this cooperative research and development agreement (CRADA) has shown the potential of a mobile tire shredding unit to economically produce TDF and to provide an alterative low cost fuel to suitable coal-fired power systems. This novel system addresses the economic barriers by processing the tires at the retailer, thereby eliminating the costs associated with hauling whole tires. The equipment incorporated into the design allow for small 1-inch chunks of TDF to be produced in a timely fashion. The TDF can then be co-fired with coal in suitable combustion systems, such as a fluidized bed. Proper use of TDF has been shown to boost efficiency and reduce emissions from power generation systems, which is beneficial to coal utilization in existing power plants. Since the original scope of work outlined in the CRADA could not be completed because of lack of progress by the CRADA members, the agreement was not extended beyond February 2004. The work completed included the detailed design of the mobile unit, a general economic analysis of the operating the system, and outreach activities.« less

Nutrient Patterns and Their Association with Socio-Demographic, Lifestyle Factors and Obesity Risk in Rural South African Adolescents

PubMed Central

Pisa, Pedro T.; Pedro, Titilola M.; Kahn, Kathleen; Tollman, Stephen M.; Pettifor, John M.; Norris, Shane A.

2015-01-01

The aim of this study was to identify and describe the diversity of nutrient patterns and how they associate with socio-demographic and lifestyle factors including body mass index in rural black South African adolescents. Nutrient patterns were identified from quantified food frequency questionnaires (QFFQ) in 388 rural South African adolescents between the ages of 11–15 years from the Agincourt Health and Socio-demographic Surveillance System (AHDSS). Principle Component Analysis (PCA) was applied to 25 nutrients derived from QFFQs. Multiple linear regression and partial R2 models were fitted and computed respectively for each of the retained principal component (PC) scores on socio-demographic and lifestyle characteristics including body mass index (BMI) for age Z scores. Four nutrient patterns explaining 79% of the total variance were identified: PCI (26%) was characterized by animal derived nutrients; PC2 (21%) by vitamins, fibre and vegetable oil nutrients; PC3 (19%) by both animal and plant derived nutrients (mixed diet driven nutrients); and PC4 (13%) by starch and folate. A positive and significant association was observed with BMI for age Z scores per 1 standard deviation (SD) increase in PC1 (0.13 (0.02; 0.24); p = 0.02) and PC4 (0.10 (−0.01; 0.21); p = 0.05) scores only. We confirmed variability in nutrient patterns that were significantly associated with various lifestyle factors including obesity. PMID:25984738

Plug and Play Solar Power: Simplifying the Integration of Solar Energy in Hybrid Applications; Cooperative Research and Development Final Report, CRADA Number CRD-13-523

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundstrom, Blake R.

The Commonwealth Scientific and Industrial Research Organisation (CSIRO) is Australia's national science agency. CSIRO received funding from the Australian Solar Institute (ASI) for the United States-Australia Solar Energy Collaboration (USASEC) project 1-USO032 Plug and Play Solar Power: Simplifying the Integration of Solar Energy in Hybrid Applications (Broader Project). The Australian Solar Institute (ASI) operated from August 2009 to December 2012 before being merged into the Australian Renewable Energy Agency (ARENA). The Broader Project sought to simplify the integration, accelerate the deployment, and lower the cost of solar energy in hybrid distributed generation applications by creating plug and play solar technology.more » CSIRO worked with the National Renewable Energy Laboratory (NREL) as set out in a Joint Work Statement to review communications protocols relevant to plug-and-play technology and perform prototype testing in its Energy System Integration Facility (ESIF). For the avoidance of doubt, this CRADA did not cover the whole of the Broader Project and only related to the work described in the Joint Work Statement, which was carried out by NREL.« less

CRADA Final Report for CRADA Number NFE-08-01671 Materials for Advanced Turbocharger Designs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maziasz, P. J.; Wilson, M.

2014-11-28

Results were obtained on residual stresses in the weld of the steel shaft to the Ni-based superalloy turbine wheel for turbochargers. Neutron diffraction studies at the HFIR Residual Stress Facility showed asymmetric tensile stresses after electron-beam welding of the wheel and shaft. A post-weld heat-treatment was found to relieve and reduce the residual stresses. Results were also obtained on cast CF8C-Plus steel as an upgrade alternative to cast irons (SiMo, Ni-resist) for higher temperature capability and performance for the turbocharger housing. CF8C-Plus steel has demonstrated creep-rupture resistance at 600-950oC, and is more creep-resistant than HK30Nb, but lacks oxidation-resistance at 800oCmore » and above in 10% water vapor. New modified CF8C-Plus Cu/W steels with Cr and Ni additions show better oxidation resistance at 800oC in 10% water vapor, and have capability to higher temperatures. For automotive gasoline engine turbocharger applications, higher temperatures are required, so at the end of this project, testing began at 1000oC and above.« less

High Specific Stiffness Shafts and Advanced Bearing Coatings for Gas Turbine Engines Final Report CRADA No. TC-1089-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbee, Troy; Chin, Herbert

At the time of the CRADA, the largest in-service gas-turbine aircraft engines strove for increased thrust and power density to meet the requirements for take-off thrust, given the increase in take-off gross weight (TOGW) associated with longer range transport requirements. The trend in modem turbo shaft engines was toward turbine shafts with higher and higher length-to-diameter ratios, which reduced the shaft critical speed. Using co nventional shaft materials, this lead to shafts that needed to operate near or above sensitive shaft bending critical speeds, therefore requiring multiple bearings and/ or multiple squeeze-film dampers to control the dynamic response. Using newmore » materials and d esign concepts this project demonstrated the use of new shaft materials which could provide increased shaft speed range above existing maximum engine speeds without encountering a critic al speed event and high vector deflections. This increased main shaft speed also resulted in decreased bearing life associated with lower heat dissipation and higher centrifugal forces. Thus, a limited effort was devoted to feasibility of higher performance bearing coatings to mitigate the speed effects.« less

Telemedicine. Final report/project accomplishments summary CRADA number 95-KCP-1014

DOE Office of Scientific and Technical Information (OSTI.GOV)

VanDeusen, A.L.

1997-04-01

This project was initiated to fill existing voids in the telemedicine equipment market. Currently, when a medical facility adds telemedicine capability to their video conference system, they must purchase expensive and bulky encoders and decoders in order to send information over the available data channel. Even with this expensive equipment, only one data type (stethoscope or ECG) can be sent at a time. In addition, since existing encoders and decoders are not designed specifically for telemedicine, special cables must be built to connect with this equipment. This project resulted in the design and construction of an encoder/decoder system that resolvedmore » these issues. The unit (referred to as the Telecoder) is designed specifically for the telemedicine market. The Telecoder is compact, handles two types of data (stethoscope and ECG) simultaneously, integrates with existing medical equipment, and is less expensive. In addition to the Telecoder module, a prototype was built that adds all the necessary logic and interfaces necessary to integrate the basic encoder design into additional Cardionics products. Although a complete integration into other Cardionics products was not in the scope of this CRADA, all the basic design work has been done to allow Cardionics to complete the work.« less

(1-3)-beta-D-glucan in association with lactate dehydrogenase as biomarkers of Pneumocystis pneumonia (PcP) in HIV-infected patients.

PubMed

Esteves, F; Lee, C-H; de Sousa, B; Badura, R; Seringa, M; Fernandes, C; Gaspar, J F; Antunes, F; Matos, O

2014-07-01

Pneumocystis pneumonia (PcP) is a major HIV-related illness caused by Pneumocystis jirovecii. Definitive diagnosis of PcP requires microscopic detection of P. jirovecii in pulmonary specimens. The objective of this study was to evaluate the usefulness of two serum markers in the diagnosis of PcP. Serum levels of (1-3)-beta-d-glucan (BG) and lactate dehydrogenase (LDH) were investigated in 100 HIV-positive adult patients and 50 healthy blood donors. PcP cases were confirmed using indirect immunofluorescence with monoclonal anti-Pneumocystis antibodies and nested-PCR to amplify the large subunit mitochondrial rRNA gene of P. jirovecii in pulmonary specimens. BG and LDH levels in serum were measured using quantitative microplate-based assays. BG and LDH positive sera were statistically associated with PcP cases (P ≤ 0.001). Sensitivity, specificity, positive/negative predictive values (PPV/NPV), and positive/negative likelihood ratios (PLR/NLR) were 91.3 %, 61.3 %, 85.1 %, 79.2 %, 2.359, and 0.142, respectively, for the BG kit assay, and 91.3 %, 35.5 %, 75.9 %, 64.7 %, 1.415 and 0.245, respectively, for the LDH test. Serologic markers levels combined with the clinical diagnostic criteria for PcP were evaluated for their usefulness in diagnosis of PcP. The most promising cutoff levels for diagnosis of PcP were determined to be 400 pg/ml of BG and 350 U/l of LDH, which combined with clinical data presented 92.8 % sensitivity, 83.9 % specificity, 92.8 % PPV, 83.9 % NPV, 5.764 PLR and 0.086 NLR (P < 0.001). This study confirmed that BG is a reliable indicator for detecting P. jirovecii infection. The combination between BG/LDH levels and clinical data is a promising alternative approach for PcP diagnosis.

Chemical and Mechanical Characterization of Diamond-Like Carbon Hard Coatings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poker, D B; Doughty, C

1999-12-28

This CRADA was intended to investigate and optimize the process used by ASTEX-PlasmaQuest for deposition of diamond-like carbon films. Approval for funding was delayed, and an unexpected move of the PlasmaQuest headquarters and research facilities prevented appropriate samples from being prepared before the end of the CRADA. Therefore, No effort was expended under this program.

KSC-98pc687

NASA Image and Video Library

1998-06-02

KENNEDY SPACE CENTER, Fla. -- Startled by the thunderous roar of the Space Shuttle Discovery’s engines as it lifts off, a bird hurriedly leaves the Launch Pad 39A area for a more peaceful site. Liftoff time for the 91st Shuttle launch and last Shuttle-Mir mission was 6:06:24 p.m. EDT June 2. On board Discovery are Mission Commander Charles J. Precourt; Pilot Dominic L. Gorie; and Mission Specialists Wendy B. Lawrence, Franklin R. Chang-Diaz, Janet Lynn Kavandi and Valery Victorovitch Ryumin. The nearly 10-day mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for the Space Shuttle orbiter Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will be returning to Earth as an STS-91 crew member after living more than four months aboard Mir

CRADA No. BNL-C-97-10 between BNL and Cotton, Inc. Final abstract and final report [Final Report of Research carried out under DOE CRADA No. BNL-C-97-10 - "Prediction of Yield in Cotton"

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The objectives of this work were to determine if the numbér of fiber cell initials varied genetically and to compare the number of initials with that of mature fibers obtained at harvest time. The method used to count the number of fiber cell initials is direct, simple, quick and done while the plant is growing. In contrast, the currently used commercial process is indirect and needs large amount mature fibers gathered at harvest time. However, all current work on cotton yield is based on fiber numbers obtained by the indirect commercial process. Consequently, it was necessary to compare results obtainedmore » from the two methods using the same plants as the source of material. The results show that the number of fiber initials per ovule differed significantly (P>0.05) for seven cultivars in 1995 and 1996. AIso, a 1997 study shows the number of fiber initials varied by 15% over boll positions and environments, with rankings among cultivars generally consistent across boll positions and sampling times. Finally, although there were differences among cultivars for initial fiber cell number, all cultivars had nearly the same number of mature lint fibers per seed. This last finding is significant. It indicates that the rate of fiber cell initiation varies among cultivars; the lower the rate, the greater the difference between the number of initials and the number of mature fiber cells. If the rate of fiber initiation is relatively high, the number of initials and mature fibers differs by about 11%; if it is low, the difference is as high as 31%. Cotton breeders may be able to use genetic differences for the number of fiber initials and/or the rate of fiber cell initiation in crop improvement programs.« less

Accuracy of ECG interpretation in competitive athletes: the impact of using standised ECG criteria.

PubMed

Drezner, Jonathan A; Asif, Irfan M; Owens, David S; Prutkin, Jordan M; Salerno, Jack C; Fean, Robyn; Rao, Ashwin L; Stout, Karen; Harmon, Kimberly G

2012-04-01

Interpretation of ECGs in athletes is complicated by physiological changes related to training. The purpose of this study was to determine the accuracy of ECG interpretation in athletes among different physician specialties, with and without use of a standised ECG criteria tool. Physicians were asked to interpret 40 ECGs (28 normal ECGs from college athletes randomised with 12 abnormal ECGs from individuals with known ciovascular pathology) and classify each ECG as (1) 'normal or variant--no further evaluation and testing needed' or (2) 'abnormal--further evaluation and testing needed.' After reading the ECGs, participants received a two-page ECG criteria tool to guide interpretation of the ECGs again. A total of 60 physicians participated: 22 primary care (PC) residents, 16 PC attending physicians, 12 sports medicine (SM) physicians and 10 ciologists. At baseline, the total number of ECGs correctly interpreted was PC residents 73%, PC attendings 73%, SM physicians 78% and ciologists 85%. With use of the ECG criteria tool, all physician groups significantly improved their accuracy (p<0.0001): PC residents 92%, PC attendings 90%, SM physicians 91% and ciologists 96%. With use of the ECG criteria tool, specificity improved from 70% to 91%, sensitivity improved from 89% to 94% and there was no difference comparing ciologists versus all other physicians (p=0.053). Providing standised criteria to assist ECG interpretation in athletes significantly improves the ability to accurately distinguish normal from abnormal findings across physician specialties, even in physicians with little or no experience.

Synthesis of a Novel Energetic Heterocyclic Oxidizer with Higher Energy and Lower Sensitivity Final Report CRADA No. TC02099.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pagoria, P.; Racoveanu, A.

2017-09-08

The project involved the synthesis of 5g of a target energetic compound, 3,4-bis(5-nitro-1,2,5- oxadiazol-4-yl)-1,2,5-oxadiazole-1-oxide (DNTF. The deliverables were the synthesis of 5g of DNTF along with quantities of the precursor compounds. In addition, small-scale safety tests on DNTF were performed, which to confirmed that DNTF has no undesirable safety properties before scaling up the synthesis in Phase II of this project.

Demonstration of Laser Plasma X-Ray Source with X-Ray Collimator Final Report CRADA No. TC-1564-99

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, S. M.; Forber, R. A.

2017-09-28

This collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and JMAR Research, Inc. (JRI), was to demonstrate that LLNL x-ray collimators can effectively increase the wafer throughput of JRI's laser based x-ray lithography systems. The technical objectives were expected to be achieved by completion of the following tasks, which are separated into two task lists by funding source. The organization (LLNL or JMAR) having primary responsibility is given parenthetically for each task.

Modeling Parasitic Energy Losses and the Impact of Advanced Tribological Concepts on Fuel Efficiency - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fenske, George

2016-11-28

Our primary task for this project was to perform FMEP calculations for a broad range of parameters including engine type [spark ignition (SI) or compression ignition (CI)], engine size, engine mode (speed and load), lubricant viscosity, asperity friction, surface finish, oil type (mineral or synthetic), and additive (friction modifier), as discussed previously [1–3]. The actual analysis was limited to a large diesel engine and it included both load and speed dependencies as well as lubricant viscosity and speed.

Design of 3x3 Focusing Array for Heavy Ion Driver Final Report on CRADA TC-02082-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martovetsky, N.

This memo presents a design of a 3x3 quadrupole array for HIF. It contains 3 D magnetic field computations of the array build with racetrack coils with and without different shields. It is shown that it is possible to have a low error magnetic field in the cells and shield the stray fields to acceptable levels. The array design seems to be a practical solution to any size array for future multi-beam heavy ion fusion drivers.

Image Matrix Processor for Volumetric Computations Final Report CRADA No. TSB-1148-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberson, G. Patrick; Browne, Jolyon

The development of an Image Matrix Processor (IMP) was proposed that would provide an economical means to perform rapid ray-tracing processes on volume "Giga Voxel" data sets. This was a multi-phased project. The objective of the first phase of the IMP project was to evaluate the practicality of implementing a workstation-based Image Matrix Processor for use in volumetric reconstruction and rendering using hardware simulation techniques. Additionally, ARACOR and LLNL worked together to identify and pursue further funding sources to complete a second phase of this project.

Compiling for Application Specific Computational Acceleration in Reconfigurable Architectures Final Report CRADA No. TSB-2033-01

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Supinski, B.; Caliga, D.

2017-09-28

The primary objective of this project was to develop memory optimization technology to efficiently deliver data to, and distribute data within, the SRC-6's Field Programmable Gate Array- ("FPGA") based Multi-Adaptive Processors (MAPs). The hardware/software approach was to explore efficient MAP configurations and generate the compiler technology to exploit those configurations. This memory accessing technology represents an important step towards making reconfigurable symmetric multi-processor (SMP) architectures that will be a costeffective solution for large-scale scientific computing.

77 FR 23475 - PJM Interconnection, L.L.C., Duke Energy Ohio, Inc., Duke Energy Kentucky, Inc; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER12-91-000, ER12-91-002, ER12-92-002] PJM Interconnection, L.L.C., Duke Energy Ohio, Inc., Duke Energy Kentucky, Inc; Notice of Filing Take notice that on April 5, 2012, Duke Energy Ohio, Inc. and Duke Energy Kentucky, Inc., tendered...

JPRS Report, China.

DTIC Science & Technology

1991-01-16

JPRS-CAR-91-002 16 JANUARY 1991, FOREIGN BROADCAST INFORMATION SERVICE -’PRS Report-- I p~provd t•= p,,.• :i..SU China REPRODUCED BY U.S. DEPARTMENT...OF COMMERCE NATIONAL TECHNICAL INFORMATION SERVICE SPRINGFIELD, VA. 22161 China JPRS-CAR-91-002 CONTENTS 16 January 1991 INTERNATIONAL 19th-Century...disasters; delegated to and retrieved from the localities arbitrarily coordination, organization, arbitration, and resolution without benefit of a legal

Efficacy of Massachusetts and 793B Vaccines Against Infectious Bronchitis Moroccan-Italy 02 Virus in Specific-Pathogen-Free Chickens and Commercial Broilers.

PubMed

Belkasmi, Sakhia F Z; Fellahi, Siham; Umar, Sajid; Delpont, Mattias; Delverdier, Maxence; Lucas, Marie-Noëlle; Bleuart, Céline; Kichou, Faouzi; Nassik, Saâdia; Guerin, Jean-Luc; Fihri, Ouafaa Fassi; Ducatez, Mariette F; El Houadfi, Mohammed

2017-12-01

The ability of commercial vaccines H120 and 4/91 to protect against Moroccan-Italy 02 infectious bronchitis virus (Mor-It02) was investigated in specific-pathogen-free (SPF) chickens and commercial broiler chickens. Commercial broiler chicks (Experiment 1) were vaccinated at the hatchery with H120 vaccine at Day 1, and challenged at Day 21 with 10 4 50% egg-infective dose (EID 50 ) of Mor-It02. All chicks were observed daily for clinical signs attributable to Mor-It02 infection during the 10 days postchallenge (pc). At 5 and 10 days pc, chicks were humanely sacrificed for necropsy examination, and tissues were collected for histopathology evaluation. To better understand the findings on commercial broilers, day-old SPF chicks were divided into five groups in a second experiment: Group Mass/4-91, vaccinated with H120 and 4/91 respectively at Days 1 and 15 of age; Group Mass/Mass, vaccinated by H120 at Days 1 and 15; Group Mass, vaccinated with H120 at Day 1; Group NV, kept unvaccinated; and Group NC, kept as a negative control (unchallenged). At Day 24 of age, Groups Mass/4-91, Mass/Mass, Mass, and NV were challenged with 10 4 EID 50 of Mor-It02. In both experiments, blood samples were collected at different periods for serologic analyses. Oropharyngeal swabs were collected for virus detection by reverse-transcription PCR. In Experiments 1 and 2, respiratory signs started as early as 24 hr pc and maximum severity was observed on Days 3 and 4 pc. The viral shedding rate was significantly lower in Group Mass/4-91 compared to other challenged groups. Serologic analysis in both experiments showed that the sera of challenged group exhibited significantly higher antibody titers than sera collected before challenge. Histopathologic investigations in SPF birds showed deciliation and hyperplasia in Group NV and less-pronounced lesions in Groups Mass/Mass and Mass. In commercial broilers vaccinated with H120 alone, hyperplasia and deciliation were observed in 90% of the tracheas. These experiments illustrated that Mor-It02 is pathogenic for chickens and a combination of live H120 and 4/91 vaccines given respectively at Day 1 and Day 15 of age confer a good protection against Mor-It02.

Report to Congress on the Activities of the DoD Office of Technology Transition

DTIC Science & Technology

2006-08-01

a 4:1 return- on -investment (ROI) to DoD from licensing revenues, CRADAs, and other partnerships. In addition, the ...nutritional high energy bar for the troops. The result was the “HooAH!” bar. Based on an invention at Natick and through a CRADA with MGM Mars, inc...production capacities for high performance RH microprocessors with a progression from radiation tolerant to radiation

Method for Processing Liver Spheroids Using an Automatic Tissue Processor

DTIC Science & Technology

2016-05-01

Harry; Kristovich, Robert L. (ECBC); and Valdes, Leah R. (ORISE) 5d. PROJECT NUMBER CRADA 1314C w/ Wake Forest University 5e. TASK NUMBER 5f. WORK...The work described in this report was authorized under project no. CRADA1314C with Wake Forest University Health Sciences. The work was started in... Wake Forest Institute for Regenerative Medicine Winston-Salem, NC iv Blank v CONTENTS 1. INTRODUCTION

Distribution and pathological features of pancreatic, ampullary, biliary and duodenal cancers resected with pancreaticoduodenectomy.

PubMed

Chandrasegaram, Manju D; Chiam, Su C; Chen, John W; Khalid, Aisha; Mittinty, Murthy L; Neo, Eu L; Tan, Chuan P; Dolan, Paul M; Brooke-Smith, Mark E; Kanhere, Harsh; Worthley, Chris S

2015-02-28

Pancreatic cancer (PC) has the worst survival of all periampullary cancers. This may relate to histopathological differences between pancreatic cancers and other periampullary cancers. Our aim was to examine the distribution and histopathologic features of pancreatic, ampullary, biliary and duodenal cancers resected with a pancreaticoduodenectomy (PD) and to examine local trends of periampullary cancers resected with a PD. A retrospective review of PD between January 2000 and December 2012 at a public metropolitan database was performed. The institutional ethics committee approved this study. There were 142 PDs during the study period, of which 70 cases were pre-2010 and 72 post-2010, corresponding to a recent increase in the number of cases. Of the 142 cases, 116 were for periampullary cancers. There were also proportionately more PD for PC (26/60, 43% pre-2010 vs 39/56, 70% post-2010, P = 0.005). There were 65/116 (56%) pancreatic, 29/116 (25%), ampullary, 17/116 (15%) biliary and 5/116 (4%) duodenal cancers. Nodal involvement occurred more frequently in PC (78%) compared to ampullary (59%), biliary (47%) and duodenal cancers (20%), P = 0.002. Perineural invasion was also more frequent in PC (74%) compared to ampullary (34%), biliary (59%) and duodenal cancers (20%), P = 0.002. Microvascular invasion was seen in 57% pancreatic, 38% ampullary, 41% biliary and 20% duodenal cancers, P = 0.222. Overall, clear margins (R0) were achieved in fewer PC 41/65 (63%) compared to ampullary 27/29 (93%; P = 0.003) and biliary cancers 16/17 (94%; P = 0.014). This study highlights that almost half of PD was performed for cancers other than PC, mainly ampullary and biliary cancers. The volume of PD has increased in recent years with an increased proportion being for PC. PC had higher rates of nodal and perineural invasion compared to ampullary, biliary and duodenal cancers.

Economic Analysis of Alternatives for PC Upgrade of OR Department Laboratory

DTIC Science & Technology

1990-09-01

DEPARTMENT LABORATORY by Chen Lung-Shan September, 1990 Thesis Advisor: Thomas E. Halwachs Approved for public release; distribution is unlimited. 91...b. RESTRICTIVE MARKINGS UNCLASSIFIED 2a. SECURITY CLASSIFICATION AUTHORITY 3. DISTRIBUTION/AVAILABILITY OF REPORT Approved for public release...Approved for public release; distribution is unlimited. Economic Analysis Of Alternatives For PC Upgrade Of OR Department Laboratory by Lung-shan Chen

Regional Anesthesia and Valproate Sodium for the Prevention of Chronic Post-Amputation Pain

DTIC Science & Technology

2014-10-01

and meetings with VAMC nursing and all study personnel while awaiting CRADA approval from VAMC NOVEMBER Duke/VA CRADA approved; start of enrollment at...Duke patient enrollment MAY Numerous meetings at Duke (Investigational Drug Service, Limb Loss Clinical Nurse Specialist, in-patient team) to discuss...Dionne Apedjihoun, CRC met with Nancy Payne, Duke Clinical Nurse /Limb Loss Specialist to trouble shoot potential patient recruitment for in and out

Technology Transfer Opportunities: On-Demand Printing in Support of National Geospatial Data

USGS Publications Warehouse

,

1997-01-01

The U.S. Geological Survey (USGS) and the 3M Company of St. Paul, Minnesota, have entered into a cooperative research and development agreement (CRADA) to investigate maps-on-demand technology to support the production of USGS mapping products. The CRADA will potentially help the USGS to develop on-demand alternatives to lithographic maps and help 3M to develop a series of commercial instant map-printing systems.

Materials-Enabled High-Efficiency (MEHE) Heavy-Duty Diesel Engines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kass, M.; Veliz, M.

2011-09-30

The purpose of this Cooperative Research and Development Agreement (CRADA) between UTBattelle, Inc. and Caterpillar, Inc. was to improve diesel engine efficiency by incorporating advanced materials to enable higher combustion pressures and temperatures necessary for improved combustion. The project scope also included novel materials for use in advanced components and designs associated with waste-heat recovery and other concepts for improved thermal efficiency. Caterpillar initially provided ORNL with a 2004 Tier 2 C15 ACERT diesel engine (designed for on-highway use) and two 600 hp motoring dynamometers. The first year of the CRADA effort was focused on establishing a heavy-duty experimental enginemore » research cell. First year activities included procuring, installing and commissioning the cell infrastructure. Infrastructure components consisted of intake air handling system, water tower, exhaust handling system, and cell air conditioning. Other necessary infrastructure items included the fuel delivery system and bottled gas handling to support the analytical instrumentation. The second year of the CRADA focused on commissioning the dynamometer system to enable engine experimentation. In addition to the requirements associated with the dynamometer controller, the electrical system needed a power factor correction system to maintain continuity with the electrical grid. During the second year the engine was instrumented and baseline operated to confirm performance and commission the dynamometer. The engine performance was mapped and modeled according to requirements provided by Caterpillar. This activity was further supported by a Work-for-Others project from Caterpillar to evaluate a proprietary modeling system. A second Work-for-Others activity was performed to evaluate a novel turbocharger design. This project was highly successful and may lead to new turbocharger designs for Caterpillar heavy-duty diesel engines. During the third (and final) year of the CRADA, a novel valve material was evaluated to assess high temperature performance and durability. A series of prototype valves, composed of a unique nickel-alloy was placed in the engine head. The engine was aggressively operated using a transient test cycle for 200 hours. The valve recession was periodically measured to determine valve performance. Upon completion of the test the valves were removed and returned to Caterpillar for additional assessment. Industrial in-kind support was available throughout the project period. Review of the status and research results were carried out on a regular basis (meetings and telecons) which included direction for future work activities. A significant portion of the industrial support was in the form of information exchange and technical consultation.« less

University of Washington/ Northwest National Marine Renewable Energy Center Tidal Current Technology Test Protocol, Instrumentation, Design Code, and Oceanographic Modeling Collaboration: Cooperative Research and Development Final Report, CRADA Number CRD-11-452

DOE Office of Scientific and Technical Information (OSTI.GOV)

Driscoll, Frederick R.

The University of Washington (UW) - Northwest National Marine Renewable Energy Center (UW-NNMREC) and the National Renewable Energy Laboratory (NREL) will collaborate to advance research and development (R&D) of Marine Hydrokinetic (MHK) renewable energy technology, specifically renewable energy captured from ocean tidal currents. UW-NNMREC is endeavoring to establish infrastructure, capabilities and tools to support in-water testing of marine energy technology. NREL is leveraging its experience and capabilities in field testing of wind systems to develop protocols and instrumentation to advance field testing of MHK systems. Under this work, UW-NNMREC and NREL will work together to develop a common instrumentation systemmore » and testing methodologies, standards and protocols. UW-NNMREC is also establishing simulation capabilities for MHK turbine and turbine arrays. NREL has extensive experience in wind turbine array modeling and is developing several computer based numerical simulation capabilities for MHK systems. Under this CRADA, UW-NNMREC and NREL will work together to augment single device and array modeling codes. As part of this effort UW NNMREC will also work with NREL to run simulations on NREL's high performance computer system.« less

High Penetration Photovoltaic Power Electronics and Energy Management Technology Research, Development and Demonstration: Cooperative Research and Development Final Report, CRADA Number CRD-13-517

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hudgins, Andrew P.

Advanced Energy Industries, Inc., will partner with DOE's National Renewable Energy Laboratory (NREL) to conduct research and development to demonstrate technologies that will increase the penetration of photovoltaic (PV) technologies for commercial and utility applications. Standard PV power control systems use simple control techniques that only provide real power to the grid. A focus of this partnership is to demonstrate how state of the art control and power electronic technologies can be combined to create a utility interactive control platform.

ALPHA SMP SYSTEM(S) Final Report CRADA No. TC-1404-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seager, M.; Beaudet, T.

Within the scope of this subcontract, Digital Equipment Corporation (DIGITAL) and the University, through the Lawrence Livermore National Laboratory (LLNL), engaged in joint research and development activities of mutual interest and benefit. The primary objectives of these activities were, for LLNL to improve its capability to perform its mission, and for DIGITAL to develop technical capability complimentary to this mission. The collaborative activities had direct manpower investments by DIGITAL and LLNL. The project was divided into four areas of concern, which were handled concurrently. These areas included Gang Scheduling, Numerical Methods, Applications Development and Code Development Tools.

Shallow Water Imaging Sonar System for Environmental Surveying Final Report CRADA No. TC-1130-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ng, L. C.; Rosenbaum, H.

The scope of this research is to develop a shallow water sonar system designed to detect and map the location of objects such as hazardous wastes or discarded ordnance in coastal waters. The system will use high frequency wide-bandwidth imaging sonar, mounted on a moving platform towed behind a boat, to detect and identify objects on the sea bottom. Resolved images can be obtained even if the targets are buried in an overlayer of silt. Reference 1 ( also attached) summarized the statement of work and the scope of collaboration.

LST CGM Generator and Viewer Final Report CRADA No. TSB-1558-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vickers, Don; Larson, Don

The purpose of this project was to jointly develop and test a software plug-in that would convert native Pro /ENGINEER digital engineering drawings to Computer Graphics Metafile (CGM) format. If it was not feasible to convert the Pro/ENGINEER files, we planned to develop and test a similar conversion of native AutoCAD engineering drawings to CGM. CGM viewer plug-ins were developed as needed. There were four main tasks in this project: 1. Requirements for CGM Plug-in 2. Product Evaluation 3. Product Development Feasibility Study 4. Developing a "Plug-In" Application.

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY13 Third Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

2013-08-06

This quarterly report summarizes the status for the project planning to obtain all the approvals required for a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). The CRADA documents have been processed by PNNL Legal Services that is also coordinating the revision effort with the industrial parties to address DOE’s comments.

The association of lean and fat mass with all-cause mortality in older adults: The Cardiovascular Health Study.

PubMed

Spahillari, A; Mukamal, K J; DeFilippi, C; Kizer, J R; Gottdiener, J S; Djoussé, L; Lyles, M F; Bartz, T M; Murthy, V L; Shah, R V

2016-11-01

Understanding contributions of lean and fat tissue to cardiovascular and non-cardiovascular mortality may help clarify areas of prevention in older adults. We aimed to define distributions of lean and fat tissue in older adults and their contributions to cause-specific mortality. A total of 1335 participants of the Cardiovascular Health Study (CHS) who underwent dual-energy x-ray absorptiometry (DEXA) scans were included. We used principal components analysis (PCA) to define two independent sources of variation in DEXA-derived body composition, corresponding to principal components composed of lean ("lean PC") and fat ("fat PC") tissue. We used Cox proportional hazards regression using these PCs to investigate the relationship between body composition with cardiovascular and non-cardiovascular mortality. Mean age was 76.2 ± 4.8 years (56% women) with mean body mass index 27.1 ± 4.4 kg/m 2 . A greater lean PC was associated with lower all-cause (HR = 0.91, 95% CI 0.84-0.98, P = 0.01) and cardiovascular mortality (HR = 0.84, 95% CI 0.74-0.95, P = 0.005). The lowest quartile of the fat PC (least adiposity) was associated with a greater hazard of all-cause mortality (HR = 1.24, 95% CI 1.04-1.48, P = 0.02) relative to fat PCs between the 25th-75th percentile, but the highest quartile did not have a significantly greater hazard (P = 0.70). Greater lean tissue mass is associated with improved cardiovascular and overall mortality in the elderly. The lowest levels of fat tissue mass are linked with adverse prognosis, but the highest levels show no significant mortality protection. Prevention efforts in the elderly frail may be best targeted toward improvements in lean muscle mass. Copyright © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Final Report of a CRADA Between Pacific Northwest National Laboratory and the Ford Motor Company (CRADA No. PNNL/265): “Deactivation Mechanisms of Base Metal/Zeolite Urea Selective Catalytic Reduction Materials, and Development of Zeolite-Based Hydrocarbon Adsorber Materials”

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Feng; Kwak, Ja Hun; Lee, Jong H.

2013-02-14

Reducing NOx emissions and particulate matter (PM) are primary concerns for diesel vehicles required to meet current LEV II and future LEV III emission standards which require 90+% NOx conversion. Currently, urea SCR as the NOx reductant and a Catalyzed Diesel Particulate Filter (CDPF) are being used for emission control system components by Ford Motor Company for 2010 and beyond diesel vehicles. Because the use of this technology for vehicle applications is new, the relative lack of experience makes it especially challenging to satisfy durability requirements. Of particular concern is being able to realistically simulate actual field aging of themore » catalyst systems under laboratory conditions. This is necessary both as a rapid assessment tool for verifying improved performance and certifiability of new catalyst formulations, and to develop a good understanding of deactivation mechanisms that can be used to develop improved catalyst materials. In addition to NOx and PM, the hydrocarbon (HC) emission standards are expected to become much more stringent during the next few years. Meanwhile, the engine-out HC emissions are expected to increase and/or be more difficult to remove. Since HC can be removed only when the catalyst becomes warm enough for its oxidation, three-way catalyst (TWC) and diesel oxidation catalyst (DOC) formulations often contain proprietary zeolite materials to hold the HC produced during the cold start period until the catalyst reaches its operating temperature (e.g., >200°C). Unfortunately, much of trapped HC tends to be released before the catalyst reaches the operating temperature. Among materials effective for trapping HC during the catalyst warm-up period, siliceous zeolites are commonly used because of their high surface area and high stability under typical operating conditions. However, there has been little research on the physical properties of these materials related to the adsorption and release of various hydrocarbon species found in the engine exhaust. For these reasons, automakers and engine manufacturers have difficulty improving their catalytic converters for meeting the stringent HC emission standards. In this collaborative program, scientists and engineers in the Institute for Integrated Catalysis at Pacific Northwest National Laboratory and at Ford Motor Company have investigated laboratory- and engine-aged SCR catalysts, containing mainly base metal zeolites. These studies are leading to a better understanding of various aging factors that impact the long-term performance of SCR catalysts and improve the correlation between laboratory and engine aging, saving experimental time and cost. We have also studied materials effective for the temporary storage of HC species during the cold-start period. In particular, we have examined the adsorption and desorption of various HC species produced during the combustion with different fuels (e.g., gasoline, E85, diesel) over potential HC adsorber materials, and measured the kinetic parameters to update Ford’s HC adsorption model. Since this CRADA has now been completed, in this final report we will provide brief summaries of most of the work carried out on this CRADA over the last several years.« less

Language used by health care professionals to describe dying at an acute care hospital.

PubMed

Wentlandt, Kirsten; Toupin, Philippe; Novosedlik, Natalia; Le, Lisa W; Zimmermann, Camilla; Kaya, Ebru

2018-05-21

To understand the language used to describe the deterioration and death of patients in an acute academic tertiary care centre, and to identify whether patient diagnoses or palliative care(PC) involvement was associated with clearer descriptions of this process. We conducted a retrospective chart review of the final admission of 150 patients who died on an inpatient internal medicine unit. Conventional and summative content analysis was performed of the language used to describe, either directly or indirectly, that the patient's death was imminent. Of the 150 deaths, the median age was 79.5(range22-101), 58% were male, and 69% spoke English. A total of 45% of deaths were from cancer, and 66% occurred with prior PC team involvement. There was no documentation of the dying process in 18(12%) of charts. In the remainder, clinicians' documentation of imminent death fell into three categories: 1 identification of the current state using specific labels, e.g. 'dying'(24.7%), or 'end of life'(15.3%), or less specific language, 'unwell' or 'doing poorly'(6.0%); 2 predicting the future state using specific or more vague predictions: e.g.'hours to days'(7.3%) or 'poor or guarded prognosis'(26.0%); 3 using care provided to the patient to imply patient status: e.g. palliative care(49.3%) or comfort care(28.7%). PC involvement, but not a malignant diagnosis, was associated with more frequent use of specific language to describe the current(p=0.004) or future state(p=0.02). Death and dying in hospital is inadequately documented and is often described using unclear and vague language. PC involvement is associated with clearer language to describe this process. Copyright © 2018. Published by Elsevier Inc.

Growth and characterization of thin Cu-phthalocyanine films on MgO(001) layer for organic light-emitting diodes

PubMed Central

2012-01-01

Surface morphology and thermal stability of Cu-phthalocyanine (CuPc) films grown on an epitaxially grown MgO(001) layer were investigated by using atomic force microscope and X-ray diffractometer. The (002) textured β phase of CuPc films were prepared at room temperature beyond the epitaxial MgO/Fe/MgO(001) buffer layer by the vacuum deposition technique. The CuPc structure remained stable even after post-annealing at 350°C for 1 h under vacuum, which is an important advantage of device fabrication. In order to improve the device performance, we investigated also current-voltage-luminescence characteristics for the new top-emitting organic light-emitting diodes with different thicknesses of CuPc layer. PMID:23181826

Growth and characterization of thin Cu-phthalocyanine films on MgO(001) layer for organic light-emitting diodes.

PubMed

Bae, Yu Jeong; Lee, Nyun Jong; Kim, Tae Hee; Cho, Hyunduck; Lee, Changhee; Fleet, Luke; Hirohata, Atsufumi

2012-11-26

Surface morphology and thermal stability of Cu-phthalocyanine (CuPc) films grown on an epitaxially grown MgO(001) layer were investigated by using atomic force microscope and X-ray diffractometer. The (002) textured β phase of CuPc films were prepared at room temperature beyond the epitaxial MgO/Fe/MgO(001) buffer layer by the vacuum deposition technique. The CuPc structure remained stable even after post-annealing at 350°C for 1 h under vacuum, which is an important advantage of device fabrication. In order to improve the device performance, we investigated also current-voltage-luminescence characteristics for the new top-emitting organic light-emitting diodes with different thicknesses of CuPc layer.

Interactions of Saccharomyces cerevisiae fermentation product and in-feed antibiotic on gastrointestinal and immunological responses in piglets challenged with Escherichia coli K88+.

PubMed

Kiarie, E; Scott, M; Krause, D O; Khazanehei, H; Khafipour, E; Nyachoti, C M

2012-12-01

Interactive effects between in-feed antibiotics (PC; 0.04% chlortetracycline + 0.004% Denagard) and a Saccharomyces cerevisiae fermentation product (XPC) were investigated. Five pens of 3 pigs/pen were randomly allotted to one of six diets consisting of control (NC; no additives), XPC alone (0.2%), PC alone, or PC plus one of three levels of XPC (0.1, 0.2, or 0.4%). On day 7, all pigs were bled for baseline serum and then orally inoculated with a 6-mL dose of 2 x 10(9) cfu/mL of ciprofloxacin-resistant Escherichia coli K88(+) (ETEC). Severity of diarrhea, using fecal score (FS), was assessed on days 8, 9, and 10. On day 10, pigs were bled and 1 pig/pen was killed to obtain gastrointestinal (GIT) samples. Remaining pigs were monitored for another 4 d and then killed to obtain GIT samples. Pigs fed PC and XPC in combination of PC had a lower (P = 0.02) FS than NC. The PC pigs had lower (P = 0.02) serum interleukin-6 and XPC pigs had higher (P < 0.01) serum tumor necrosis factor-α than NC pigs. Ileal mucosal ETEC count was lower on day 10 (P = 0.04) and day 14 (P < 0.01) when additives were fed in combination. Microbiome analysis of day 10 digesta using pyrosequencing showed that pigs fed the PC with XPC had enriched (P = 0.01) Streptococcaceae family than PC fed alone. On day 10, pigs fed PC alone and in combination with XPC at a lower dose had shallower (P = 0.01) crypt depth than those fed higher doses of XPC, XPC alone, or NC. Pigs fed XPC had a thicker colon wall on day 10 (P < 0.01) compared to those fed non-XPC diets. Ileal and colonic digesta NH(3) concentration was lower (P < 0.05) for pigs fed additives-containing diets on days 10 and 14. Feeding PC or XPC reduced diarrhea and the number of ETEC attached to the ileal mucosa; however, responses suggest independent and interactive effects that might be associated with the nature of these additives.

QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components.

PubMed

Shahlaei, Mohsen; Sabet, Razieh; Ziari, Maryam Bahman; Moeinifard, Behzad; Fassihi, Afshin; Karbakhsh, Reza

2010-10-01

Quantitative relationships between molecular structure and methionine aminopeptidase-2 inhibitory activity of a series of cytotoxic anthranilic acid sulfonamide derivatives were discovered. We have demonstrated the detailed application of two efficient nonlinear methods for evaluation of quantitative structure-activity relationships of the studied compounds. Components produced by principal component analysis as input of developed nonlinear models were used. The performance of the developed models namely PC-GRNN and PC-LS-SVM were tested by several validation methods. The resulted PC-LS-SVM model had a high statistical quality (R(2)=0.91 and R(CV)(2)=0.81) for predicting the cytotoxic activity of the compounds. Comparison between predictability of PC-GRNN and PC-LS-SVM indicates that later method has higher ability to predict the activity of the studied molecules. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

Importance of initial and final state effects for azimuthal correlations in p + Pb collisions

DOE PAGES

Greif, Moritz; Greiner, Carsten; Schenke, Bjorn; ...

2017-11-27

In this work, we investigate the relative importance of initial and final state effects on azimuthal correlations of gluons in low and high multiplicity p+Pb collisions. To achieve this, we couple Yang-Mills dynamics of pre-equilibrium gluon fields (IP-GLASMA) to a perturbative QCD based parton cascade for the final state evolution (BAMPS) on an event-by-event basis. We find that signatures of both the initial state correlations and final state interactions are seen in azimuthal correlation observables, such as v 2 {2PC} (p T), their strength depending on the event multiplicity and transverse momentum. Initial state correlations dominate v 2 {2PC} (pmore » T) in low multiplicity events for transverse momenta p T > 2 GeV. Lastly, while final state interactions are dominant in high multiplicity events, initial state correlations affect v 2 {2PC} (p T) for p T > 2 GeV as well as the pT integrated v 2 {2PC}.« less

Importance of initial and final state effects for azimuthal correlations in p + Pb collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greif, Moritz; Greiner, Carsten; Schenke, Bjorn

In this work, we investigate the relative importance of initial and final state effects on azimuthal correlations of gluons in low and high multiplicity p+Pb collisions. To achieve this, we couple Yang-Mills dynamics of pre-equilibrium gluon fields (IP-GLASMA) to a perturbative QCD based parton cascade for the final state evolution (BAMPS) on an event-by-event basis. We find that signatures of both the initial state correlations and final state interactions are seen in azimuthal correlation observables, such as v 2 {2PC} (p T), their strength depending on the event multiplicity and transverse momentum. Initial state correlations dominate v 2 {2PC} (pmore » T) in low multiplicity events for transverse momenta p T > 2 GeV. Lastly, while final state interactions are dominant in high multiplicity events, initial state correlations affect v 2 {2PC} (p T) for p T > 2 GeV as well as the pT integrated v 2 {2PC}.« less

Enhanced activity and stability of binuclear iron (III) phthalocyanine on graphene nanosheets for electrocatalytic oxygen reduction in acid

NASA Astrophysics Data System (ADS)

Li, Tengfei; Peng, Yingxiang; Li, Kai; Zhang, Rui; Zheng, Lirong; Xia, Dingguo; Zuo, Xia

2015-10-01

Binuclear iron (III) phthalocyanine (bi-FePc) and iron (III) phthalocyanine (FePc) are synthesized in situ on graphene nanosheets (GNS) by a microwave-assisted method. TEM, ultraviolet-visible spectroscopy and Raman spectroscopy confirm that bi-FePc is supported on GNS through π-π interactions. The catalytic activity of the bi-FePc/GNS and FePc/GNS composites in the oxygen reduction reaction (ORR) is investigated by CV and RDE measurements. The bi-FePc/GNS composite shows a more positive onset potential (0.12 V vs. Hg/Hg2SO4) for the ORR than FePc/GNS (-0.02 V vs. Hg/Hg2SO4), and a four-electron mechanism similar to commercial Pt/C (0.22 V vs. Hg/Hg2SO4). Moreover, bi-FePc/GNS exhibits good stability with 100% retention after 36,000 s, while Pt/C has a retention of only 50% after the same period. Additionally, bi-FePc/GNS shows higher tolerance toward methanol than the Pt/C catalyst. XPS and X-ray absorption fine structure spectroscopy demonstrate that compared with FePc/GNS, bi-FePc/GNS possesses a higher concentration of Fe3+ and smaller skeleton radius of the phthalocyanine ring, which has a square-planar structure that evidently favors the ORR. Thus, bi-FePc/GNS is a promising candidate as a cathode catalyst in direct methanol fuel cells.

History of gonorrhea and prostate cancer in a population-based case-control study in Mexico.

PubMed

Vázquez-Salas, Ruth Argelia; Torres-Sánchez, Luisa; López-Carrillo, Lizbeth; Romero-Martínez, Martín; Manzanilla-García, Hugo A; Cruz-Ortíz, Carlos Humberto; Mendoza-Peña, Fernando; Jiménez-Ríos, Miguel Ángel; Rodríguez-Covarrubias, Francisco; Hernández-Toríz, Narciso; Moreno-Alcázar, Othón

2016-02-01

We evaluated the association between a history of sexually transmitted diseases (STDs) and the risk for prostate cancer (PC) among Mexican males. PC incident cases (n=402) that were identified at six public hospitals in Mexico City were matched by age (±5 years) with 805 population controls with no history of PC. By face-to-face interview, we obtained information about sexual history, previous STDs, sociodemographic characteristics, and familial history of PC. An unconditional logistic regression model was used to estimate the risk for PC. A total of 16.6% of men reported having had at least one previous STD, and the most frequently reported STD was gonorrhea (10.5%). After adjusting by PC familial history, the history of STD was associated with a two-fold greater risk of PC: odds ratio (OR)=2.67; 95% confidence interval (95% CI=1.91-3.73). When each STD was evaluated separately, only gonorrhea was associated with a significant increase in PC risk (OR=3.04; 95% CI=1.99-4.64). These associations were similar when we stratified by low-risk PC (Gleason <7) and high-risk PC (Gleason ≥7). These results confirm that STDs, and particularly gonorrhea, may play an etiological role in PC among Mexican males, which is consistent with a previous report from a multiethnic cohort. Copyright © 2015 Elsevier Ltd. All rights reserved.

32 CFR Appendix B to Part 28 - Disclosure Form To Report Lobbying

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Disclosure Form To Report Lobbying B Appendix B to Part 28 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND... Report Lobbying EC23OC91.000 EC23OC91.001 EC23OC91.002 ...

32 CFR Appendix B to Part 28 - Disclosure Form To Report Lobbying

Code of Federal Regulations, 2014 CFR

2014-07-01

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32 CFR Appendix B to Part 28 - Disclosure Form To Report Lobbying

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Disclosure Form To Report Lobbying B Appendix B to Part 28 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND... Report Lobbying EC23OC91.000 EC23OC91.001 EC23OC91.002 ...

32 CFR Appendix B to Part 28 - Disclosure Form To Report Lobbying

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Disclosure Form To Report Lobbying B Appendix B to Part 28 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND... Report Lobbying EC23OC91.000 EC23OC91.001 EC23OC91.002 ...

32 CFR Appendix B to Part 28 - Disclosure Form To Report Lobbying

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Disclosure Form To Report Lobbying B Appendix B to Part 28 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND... Report Lobbying EC23OC91.000 EC23OC91.001 EC23OC91.002 ...

Hydrogen Compressor Reliability Investigation and Improvement. Cooperative Research and Development Final Report, CRADA Number CRD-13-514

DOE Office of Scientific and Technical Information (OSTI.GOV)

Terlip, Danny

2016-03-28

Diaphragm compressors have become the primary source of on-site hydrogen compression for hydrogen fueling stations around the world. NREL and PDC have undertaken two studies aimed at improving hydrogen compressor operation and reducing the cost contribution to dispensed fuel. The first study identified the failure mechanisms associated with mechanical compression to reduce the maintenance and down-time. The second study will investigate novel station configurations to maximize hydrogen usage and compressor lifetime. This partnership will allow for the simulation of operations in the field and a thorough analysis of the component failure to improve the reliability of diaphragm compression.

Test of a 250 kVA Battery-Inverter System Micro-Grid: Cooperative Research and Development Final Report, CRADA Number CRD-11-460

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kramer, William; Martin, Greg; Lundstrom, Blake

Portland General Electric (PGE) is installing a 5-megawatt (MW) lithium-ion-based battery-inverter system (BIS) in Salem, Oregon, as part of the Pacific Northwest Smart Grid Demonstration Project. NREL will assist PGE in testing a 250-kilovolt-ampere (kVA) portion of the BIS in order to verify correct operation and minimize risk to subsequent demonstrations. In this project NREL will providetechnical support for the 250-kVA test and will work with PGE to write a test plan and evaluate the system in the lab before deployment in the field.

Development of Carbon-14 Waste Destruction and Recovery System Using AC Plasma Torch Technology Final Report CRADA No. TC02108.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Althouse, P.; McKannay, R. H.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and ISOFLEX USA (ISOFLEX), to 1) develop and test a prototype waste destruction system ("System") using AC plasma torch technology to break down and drastically reduce the volume of Carbon-14 (C-14) contaminated medical laboratory wastes while satisfying all environmental regulations, and 2) develop and demonstrate methods for recovering 99%+ of the carbon including the C-14 allowing for possible re-use as a tagging and labeling tool in the biomedical industry.

Investigation of the fundamentals of low-energy nanosecond pulse ignition: Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallner, Thomas; Scarcelli, Riccardo; Zhang, Anqi

A detailed investigation of the fundamentals of low-energy nanosecond pulse ignition was performed with the objective to overcome the barrier presented by limited knowledge and characterization of nonequilibrium plasma ignition for realistic internal combustion engine applications (be it in the automotive or power generation field) and shed light on the mechanisms which improve the performance of the advanced TPS ignition system compared to conventional state-of-the-art hardware. Three main tasks of the research included experimental evaluation on a single-cylinder automotive gasoline engine, experimental evaluation on a single-cylinder stationary natural gas engine and energy quantification using x-ray diagnostics.

Artificial Retina Project: Final Report for CRADA ORNL 01-0625

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenbaum, E; Little, J

The U.S. Department of Energy’s Artificial Retina Project is a collaborative, multi-institutional effort to develop an implantable microelectronic retinal prosthesis that restores useful vision to people blinded by retinal diseases. The ultimate goal of the project is to restore reading ability, facial recognition, and unaided mobility in people with retinitis pigmentosa and age-related macular degeneration. The project taps into the unique research technologies and resources developed at DOE national laboratories to surmount the many technical challenges involved with developing a safe, effective, and durable product. The research team includes six DOE national laboratories, four universities, and private industry.

Investigations into Performance and Lifetime Enhancements of OPV Devices: Cooperative Research and Development Final Report, CRADA Number CRD-08-263

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginley, D.

2014-06-01

To evaluate Plextronics new additives and derivatives in lithium-ion Battery Applications, Plextronics will provide to NREL, a starting point, including materials and initial data for proof of concept. The central focus of this project is to acertain the nature of the efficacy of the Plextronics additives through physical and electrical characterization, including evaluations of new derivatives, system evaluations on batteries made with Plexcore and to study long term cycling performance differences. The initial focus is to establish Plexcore mode of action to support the commercialization of the first commercial evaluations of Plexcore in Sept. 2013.

Development of an Ultra-Low-Cost Solar Water Heater: Cooperative Research and Development Final Report, CRADA Number CRD-12-487

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merrigan, Tim

2016-02-17

NREL and RhoTech will collaborate to bring long-lived, ultra-low-cost, high-performance solar water heaters (SWH) to market readiness. An existing RhoTech design uses seam-welded polymer thin films to make an unglazed thermosiphon, and this design will be modified to improve durability through ultraviolet and overheat protection, and to improve performance by adding a glazing to the collector. Two generations of the new glazed systems will be tested in the field, resulting in a robust market-ready SWH design that can be installed for under $1,000 without rebates.

Development of an Opto-Acoustic Recanalization System Final Report CRADA No. 1314-96

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silva, L. D.; Adam, H. R.

The objective of the project was to develop an ischemic stroke treatient system that restores blood flow to the brain by removing occlusions using acoustic energy created by fiber optic delivery of laser light, a process called Opto Acoustic Recanalization (OAR). The key tasks of the project were to select a laser system, quantify temperature, pressure and particle size distribution, and develop a prototype device incorporating a feedback mechanism. System parameters were developed to cause emulsification while attempting to minimize particle size and collateral damage. The prototype system was tested in animal models and resulted in no visible collateral damage.

High Temperature Catalytic Combustion Suppports Final Report CRADA No. TSB-0841-94

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hair, Lucy; Magno, Scott

This Small Business CRADA between LLNL and Catalytica was executed on January 25, 1995. The total estimated cost of this project was 113K. LLNL's contribution was estimated at $50K funded under the DOE/Defense Program Small Business Initiative. Catalytica's in-kind contribution was estimated at 63K. Catalytic combusion catalyst systems operate at temperatures from 600°C to above 1300°C. Catalytica has developed technology that limits the catalyst temperature to below 1000°C. At temperatures in the range of 850 to 1000°C, the thermal stability of the catalyst is an important issue. Typical supports such as stabilized aluminas, hexaluminates, zirconia and stabilized zirconia supports aremore » typically used but lack either thermal stability or other desirable properties. Catalytica had developed a new concept for thermally stable mixed oxide supports but this concept required the preparation of molecularly uniform precursors; that is, prior to high temperature treatment of these materials, the elements that make up the mixed oxide must be as nearly uniform as possible on a molecular level. The technique of sol gel processing appeared to be the preferred technique to make these molecularly uniform precursors, and a cooperative program with LLNL was established to prepare and test the proposed compounds. Catalytica proposed the composition and concentration levels for the materials to be prepared.« less

Wireless Sensor for Measuring Pump Efficiency: Small Business Voucher Project with KCF Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fugate, David L.; Liu, Xiaobing; Gehl, Anthony C.

This document is to fulfill the final report requirements for the Small Business Voucher (SBV) CRADA project with ORNL and KCF Technologies (CRADA/NFE-16-06133). Pumping systems account for nearly 20% of the world’s electrical energy demand and range from 25-50% of the energy usage in many industrial and building power plants. The energy cost is the largest element in the total cost of owning a pump (~40%). In response to a recent DOE mandate for improved pump efficiency pump manufacturers are preparing for the changes that the impending regulations will bring, including design improvements. This mandate also establishes a need formore » new low cost pump efficiency measurement systems. The standard industry definition of pump efficiency is the mechanical water horsepower delivered divided by the electrical horsepower input to the motor. KCF Technologies has developed a new sensor measurement technique to estimate fluid pump efficiency using a thermodynamic approach. KCF Technologies applied for a SBV grant with ORNL as the research partner. KCF needed a research partner with the proper facilities to demonstrate the efficacy of its wireless sensor unit for measuring pump efficiency. The ORNL Building Technologies Research and Integration Center (BTRIC) test resources were used to test and demonstrate the successful measurement of pump efficiency with the KCF sensor technology. KCF is now working on next steps to commercialize this sensing technology.« less

High Efficiency Water Heating Technology Development Final Report. Part I, Lab/Field Performance Evaluation and Accelerated Life Testing of a Hybrid Electric Heat Pump Water Heater (HPWH)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, Van D.; Murphy, Richard W.; Rice, C. Keith

DOE has supported efforts for many years with the objective of getting a water heater that uses heat pump technology (aka a heat pump water heater or HPWH) successfully on the residential equipment market. The most recent previous effort (1999-2002) produced a product that performed very well in ORNL-led accelerated durability and field tests. The commercial partner for this effort, Enviromaster International (EMI), introduced the product to the market under the trade name Watter$aver in 2002 but ceased production in 2005 due to low sales. A combination of high sales price and lack of any significant infrastructure for service aftermore » the sale were the principal reasons for the failure of this effort. What was needed for market success was a commercial partner with the manufacturing and market distribution capability necessary to allow economies of scale to lead to a viable unit price together with a strong customer service infrastructure. General Electric certainly meets these requirements, and knowing of ORNL s expertise in this area, approached ORNL with the proposal to partner in a CRADA to produce a high efficiency electric water heater. A CRADA with GE was initiated early in Fiscal Year, 2008. GE initially named its product the Hybrid Electric Water Heater (HEWH).« less

Ca/Alq3 hybrid cathode buffer layer for the optimization of organic solar cells based on a planar heterojunction

NASA Astrophysics Data System (ADS)

El Jouad, Z.; Barkat, L.; Stephant, N.; Cattin, L.; Hamzaoui, N.; Khelil, A.; Ghamnia, M.; Addou, M.; Morsli, M.; Béchu, S.; Cabanetos, C.; Richard-Plouet, M.; Blanchard, P.; Bernède, J. C.

2016-11-01

Use of efficient anode cathode buffer layer (CBL) is crucial to improve the efficiency of organic photovoltaic cells. Here we show that using a double CBL, Ca/Alq3, allows improving significantly cell performances. The insertion of Ca layer facilitates electron harvesting and blocks hole collection, leading to improved charge selectivity and reduced leakage current, whereas Alq3 blocks excitons. After optimisation of this Ca/Alq3 CBL using CuPc as electron donor, it is shown that it is also efficient when SubPc is substituted to CuPc in the cells. In that case we show that the morphology of the SubPc layer, and therefore the efficiency of the cells, strongly depends on the deposition rate of the SubPc film. It is necessary to deposit slowly (0.02 nm/s) the SubPc films because at higher deposition rate (0.06 nm/s) the films are porous, which induces leakage currents and deterioration of the cell performances. The SubPc layers whose formations are kinetically driven at low deposition rates are more uniform, whereas those deposited faster exhibit high densities of pinholes.

Automated feature extraction and classification from image sources

USGS Publications Warehouse

,

1995-01-01

The U.S. Department of the Interior, U.S. Geological Survey (USGS), and Unisys Corporation have completed a cooperative research and development agreement (CRADA) to explore automated feature extraction and classification from image sources. The CRADA helped the USGS define the spectral and spatial resolution characteristics of airborne and satellite imaging sensors necessary to meet base cartographic and land use and land cover feature classification requirements and help develop future automated geographic and cartographic data production capabilities. The USGS is seeking a new commercial partner to continue automated feature extraction and classification research and development.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davison, B. H.; Kuritz, T.

This CRADA was a collaborative effort between the Oak Ridge National Laboratory (ORNL) and Sass & Sass, Inc. It also had involvement with the University of Tennessee Knoxville (UTK) The CRADA focused on the development and commercialization in the U.S. of the substance developed in Russia with potential veterinary applications. The project addressed validation and further characterization of the lead substance necessary for its commercialization in the U.S. market as a veterinarian biologic and at the commercialization of the product for the Russian market, by the Russian group establishing of sustainability of the Russian research groups.

[Changes in the thrombophilic status in patients with pre-eclampsia].

PubMed

Baptista-González, H A; Rosenfeld-Mann, F; Saavedra-Trejo, M R; Castro-López, J L; Peñuela-Olaya, M A

1999-04-01

The object of this study was to evaluate the changes in fibrinolysis and clotting inhibitors in patients with preeclampsia and to describe the connection between preeclampsia and blood pressure values. Two groups of pregnant women were prospectively studied at delivery: group 1 women without preeclampsia and group 2 patients with preeclampsia. The variables that were registered are: diastolic blood pressure (DBP), systolic blood pressure (SBP), mean blood pressure (MBP), hemoglobin (Hb), platelet count (Plt), lupus like inhibitor, anticardiolipin antibodies (ACA), antinuclear antibodies (ANA), fibronectina, D dimer, protein S (PS), protein C (PC) and vo Willebrand factor (vWF). 62 pregnant women were included. The patients of group 2 presented high values of Hb (p 0.01), fibronectin (p 0.0001), D-dimer (p 0.01) and lower PC (p 0.04). We found an association between fibronectin and higher values of SBP, DBP, MBP and Hb (p 0.0007) versus lower values of VFW and PC (p 0.002). The low values of total PS were associated with high D-dimer and SBP results (p 0.04 and 0.002 respectively). All patients were ACA/ANA negative. In preclampsia there is a increased hemoconcentration and drop in clotting inhibitors (PC), without fibrinolytic compensatory response (lower D-dimer) and remarked vasopressive effect (hig fibronectin). This changes depend on the stratification of blood pressure. Th SBP and MBP values depend on the haemodynamic changes (Hb, fibronectin), while the increase in DBP expresses a non compensated thrombophilic state.

LiverTox: Advanced QSAR and Toxicogeomic Software for Hepatotoxicity Prediction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, P-Y.; Yuracko, K.

2011-02-25

YAHSGS LLC and Oak Ridge National Laboratory (ORNL) established a CRADA in an attempt to develop a predictive system using a pre-existing ORNL computational neural network and wavelets format. This was in the interest of addressing national needs for toxicity prediction system to help overcome the significant drain of resources (money and time) being directed toward developing chemical agents for commerce. The research project has been supported through an STTR mechanism and funded by the National Institute of Environmental Health Sciences beginning Phase I in 2004 (CRADA No. ORNL-04-0688) and extending Phase II through 2007 (ORNL NFE-06-00020). To attempt themore » research objectives and aims outlined under this CRADA, state-of-the-art computational neural network and wavelet methods were used in an effort to design a predictive toxicity system that used two independent areas on which to base the system’s predictions. These two areas were quantitative structure-activity relationships and gene-expression data obtained from microarrays. A third area, using the new Massively Parallel Signature Sequencing (MPSS) technology to assess gene expression, also was attempted but had to be dropped because the company holding the rights to this promising MPSS technology went out of business. A research-scale predictive toxicity database system called Multi-Intelligent System for Toxicogenomic Applications (MISTA) was developed and its feasibility for use as a predictor of toxicological activity was tested. The fundamental focus of the CRADA was an attempt and effort to operate the MISTA database using the ORNL neural network. This effort indicated the potential that such a fully developed system might be used to assist in predicting such biological endpoints as hepatotoxcity and neurotoxicity. The MISTA/LiverTox approach if eventually fully developed might also be useful for automatic processing of microarray data to predict modes of action. A technical paper describing the methods and technology used in the CRADA has been published. This paper was entitled “A Toxicity Evaluation and Predictive System Based on Neural Networks and Wavelets” and appeared in an American Chemical Society peer-reviewed publication this year (J. Chem. Inf. Model. 47: 676685, 2007). A patent application was filed but later abandoned.« less

KSC-98pc587

NASA Image and Video Library

1998-05-02

Under the supervision of Boeing technicians, the Alpha Magnetic Spectrometer (AMS), a payload slated to fly on STS-91, is undergoing a final weight and balance check on the Launch Package Integration Stand in the Space Station Processing Facility (SSPF). Next, it will be placed in the Payload Canister and transported to Launch Complex 39A where it will be installed into Space Shuttle Discovery's payload bay. Weighing in at approximately three tons, the AMS is a major particle physics experiment that will look for cosmic antimatter originating from outside our galaxy. The data it gathers could also give clues about the mysterious "dark matter" that may make up 90 percent or more of the universe. STS-91 is scheduled to be launched on June 2 with a launch window opening around 6:10 p.m. EDT. The mission will also feature the ninth Shuttle docking with the Russian Space Station Mir, the first Mir docking for Discovery, and the conclusion of Phase I of the joint U.S.-Russian International Space Station Program. The STS-91 flight crew includes Commander Charles Precourt; Pilot Dominic Gorie; and Mission Specialists Wendy B. Lawrence; Franklin Chang-Diaz, Ph.D.; Janet Kavandi, Ph.D.; and Valery Ryumin, with the Russian Space Agency. Andrew Thomas, Ph.D., will be returning to Earth with the crew after living more than four months aboard Mir

Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles.

PubMed

Stephens, Camilla; Castiella, Agustin; Gomez-Moreno, Eva M; Otazua, Pedro; López-Nevot, Miguel-Ángel; Zapata, Eva; Ortega-Alonso, Aida; Ruiz-Cabello, Francisco; Medina-Cáliz, Inmaculada; Robles-Díaz, Mercedes; Soriano, German; Roman, Eva; Hallal, Hacibe; Moreno-Planas, José M; Prieto, Martin; Andrade, Raúl J; Lucena, M Isabel

2016-09-01

Positive autoantibody (AAB) titres are commonly encountered in autoimmune hepatitis (AIH) and in a proportion of drug-induced liver injury (DILI) patients. The underlying mechanism for selective AAB occurrence in DILI is unknown, but could be associated with variations in immune-associated genes. Hence, we aimed to analyse human leucocyte antigen (HLA) allele compositions in DILI with positive (+) and negative (-) AAB titres and in AIH patients. High-resolution genotyping of HLA class I (A, B, C) and II (DRB1, DQB1) loci was performed on 207 DILI and 50 idiopathic AIH patients and compared with 885 healthy Spanish controls. Compared with controls, HLA-B*08:01 [44 vs. 9.7%, P=3.7E-13/corrected P-value (Pc)=1.0E-11], C*07:01 (46 vs. 24%, P=6.4E-04/Pc=0.012), DRB1*03:01 (58 vs. 21.5%, P=5.0E-09/Pc=1.0E-07) and DQB1*02:01 (56 vs. 22%, P=6.8E-08/Pc=9.0E-07) were significantly more frequent in AIH patients. The HLA-A*01:01 frequency was increased in the same population, but did not reach significance after Bonferroni's correction (34 vs. 19%, P=0.02/Pc=0.37). Fifty-eight of 207 DILI patients presented positive titres for at least one AAB (predominantly antinuclear antibody 76% and antismooth muscle antibody 28%). There was a tendency towards higher representation of DRB1*14:01 and DQB1*05:03 in DILI AAB+ compared with DILI AAB- (13.8 vs. 4.0%, P=0.02/Pc=0.5; 13.8 vs. 4.7%, P=0.04/Pc=0.5). The presence of HLA alleles B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 and possibly A*01:01 enhances the risk of AIH (type 1) in Spanish patients. These alleles form part of the ancestral haplotype 8.1. HLA-DRB1*14:01 and DQB1*05:03 could potentially increase the risk of positive AAB (particularly antinuclear antibody) in Spanish DILI patients.

NASA PC software evaluation project

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Kuan, Julie C.

1986-01-01

The USL NASA PC software evaluation project is intended to provide a structured framework for facilitating the development of quality NASA PC software products. The project will assist NASA PC development staff to understand the characteristics and functions of NASA PC software products. Based on the results of the project teams' evaluations and recommendations, users can judge the reliability, usability, acceptability, maintainability and customizability of all the PC software products. The objective here is to provide initial, high-level specifications and guidelines for NASA PC software evaluation. The primary tasks to be addressed in this project are as follows: to gain a strong understanding of what software evaluation entails and how to organize a structured software evaluation process; to define a structured methodology for conducting the software evaluation process; to develop a set of PC software evaluation criteria and evaluation rating scales; and to conduct PC software evaluations in accordance with the identified methodology. Communication Packages, Network System Software, Graphics Support Software, Environment Management Software, General Utilities. This report represents one of the 72 attachment reports to the University of Southwestern Louisiana's Final Report on NASA Grant NGT-19-010-900. Accordingly, appropriate care should be taken in using this report out of context of the full Final Report.

Electron Beam Cured Epoxy Resin Composites for High Temperature Applications

NASA Technical Reports Server (NTRS)

Janke, Christopher J.; Dorsey, George F.; Havens, Stephen J.; Lopata, Vincent J.; Meador, Michael A.

1997-01-01

Electron beam curing of Polymer Matrix Composites (PMC's) is a nonthermal, nonautoclave curing process that has been demonstrated to be a cost effective and advantageous alternative to conventional thermal curing. Advantages of electron beam curing include: reduced manufacturing costs; significantly reduced curing times; improvements in part quality and performance; reduced environmental and health concerns; and improvement in material handling. In 1994 a Cooperative Research and Development Agreement (CRADA), sponsored by the Department of Energy Defense Programs and 10 industrial partners, was established to advance the electron beam curing of PMC technology. Over the last several years a significant amount of effort within the CRADA has been devoted to the development and optimization of resin systems and PMCs that match the performance of thermal cured composites. This highly successful materials development effort has resulted in a board family of high performance, electron beam curable cationic epoxy resin systems possessing a wide range of excellent processing and property profiles. Hundreds of resin systems, both toughened and untoughened, offering unlimited formulation and processing flexibility have been developed and evaluated in the CRADA program.

Identification of Biomarkers for PKD1 Using Urinary Exosomes

PubMed Central

Hogan, Marie C.; Bakeberg, Jason L.; Gainullin, Vladimir G.; Irazabal, Maria V.; Harmon, Amber J.; Lieske, John C.; Charlesworth, M. Cristine; Johnson, Kenneth L.; Madden, Benjamin J.; Zenka, Roman M.; McCormick, Daniel J.; Sundsbak, Jamie L.; Heyer, Christina M.; Torres, Vicente E.; Harris, Peter C.

2015-01-01

Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either PKD1 or PKD2, which encode polycystin-1 (PC1) or polycystin-2 (PC2), respectively. PC1 and PC2 are secreted on urinary exosome-like vesicles (ELVs) (100-nm diameter vesicles), in which PC1 is present in a cleaved form and may be complexed with PC2. Here, label-free quantitative proteomic studies of urine ELVs in an initial discovery cohort (13 individuals with PKD1 mutations and 18 normal controls) revealed that of 2008 ELV proteins, 9 (0.32%) were expressed at significantly different levels in samples from individuals with PKD1 mutations compared to controls (P<0.03). In samples from individuals with PKD1 mutations, levels of PC1 and PC2 were reduced to 54% (P<0.02) and 53% (P<0.001), respectively. Transmembrane protein 2 (TMEM2), a protein with homology to fibrocystin, was 2.1-fold higher in individuals with PKD1 mutations (P<0.03). The PC1/TMEM2 ratio correlated inversely with height-adjusted total kidney volume in the discovery cohort, and the ratio of PC1/TMEM2 or PC2/TMEM2 could be used to distinguish individuals with PKD1 mutations from controls in a confirmation cohort. In summary, results of this study suggest that a test measuring the urine exosomal PC1/TMEM2 or PC2/TMEM2 ratio may have utility in diagnosis and monitoring of polycystic kidney disease. Future studies will focus on increasing sample size and confirming these studies. The data were deposited in the ProteomeXchange (identifier PXD001075). PMID:25475747

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balachandran, U.

The purpose of this CRADA is to develop a fabrication process to reduce the manufacturing cost for a very compact, high temperature, film-on-foil high energy-density PLZT (Pb-La-Zr- Ti-O) capacitor. Motivation for this CRADA is derived from the DOE’s Office of Vehicle Technologies (OVT) program, which seeks to advance technologies to improve vehicle fuel efficiency in the mid-term and facilitate the transition to electric drive vehicles over the longterm. The objective of Argonne’s work is to develop and characterize high-performance capacitors on base-metal foils. The PLZT film-on-foil prepared using a spin-coating technique

Cast CF8C-Plus Stainless Steel for Turbocharger Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maziasz, P.J.; Shyam, A.; Evans, N.D.

2010-06-30

The purpose of this Cooperative Research and Development Agreement (CRADA) project is to provide the critical test data needed to qualify CF8C-Plus cast stainless steel for commercial production and use for turbocharger housings with upgraded performance and durability relative to standard commercial cast irons or stainless steels. The turbocharger technologies include, but are not limited to, heavy-duty highway diesel engines, and passenger vehicle diesel and gasoline engines. This CRADA provides additional critical high-temperature mechanical properties testing and data analysis needed to quality the new CF8C-Plus steels for turbocharger housing applications.

22 CFR Appendix B to Part 311 - Disclosure Form To Report Lobbying

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Disclosure Form To Report Lobbying B Appendix B to Part 311 Foreign Relations PEACE CORPS NEW RESTRICTIONS ON LOBBYING Pt. 311, App. B Appendix B to Part 311—Disclosure Form To Report Lobbying EC13OC91.000 EC13OC91.001 EC13OC91.002 ...

The Distribution of Fallout Radionuclides (Sr 90, I 131, and Cs 137) in Naturally Contaminated Milk (in German)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lagoni, H.; Paakkola, O.; Peters, K. H.

1963-01-01

The distribution of Sr 90, I 131, and Cs 137 in milk was investigated in the autumn of 1962. The concentration of the radioisotopes in I kg of the milk used was 44.5 pC Sr 90, 176.0 pC Sr 89, 106.0 pC I 131, and 91.0 pC Cs 137. The distribution of the isotopes in the fatty part of the milk and in the non-fatty constituents was determined and the results are tabulated, showing that most of the radioisotopes follow the aqueous phase to the skim milk. 60% of the radioiodine goes to the butter fat. In acid precipitation ofmore » the skim milk more than 90% of the Sr 90 goes with the whey, whereas the I 131 and Cs 137 go with the casein.« less

14 CFR 91.805 - Final compliance: Subsonic airplanes.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Final compliance: Subsonic airplanes. 91... § 91.805 Final compliance: Subsonic airplanes. Except as provided in §§ 91.809 and 91.811, on and after January 1, 1985, no person may operate to or from an airport in the United States any subsonic airplane...

14 CFR 91.805 - Final compliance: Subsonic airplanes.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Final compliance: Subsonic airplanes. 91... § 91.805 Final compliance: Subsonic airplanes. Except as provided in §§ 91.809 and 91.811, on and after January 1, 1985, no person may operate to or from an airport in the United States any subsonic airplane...

14 CFR 91.805 - Final compliance: Subsonic airplanes.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Final compliance: Subsonic airplanes. 91... § 91.805 Final compliance: Subsonic airplanes. Except as provided in §§ 91.809 and 91.811, on and after January 1, 1985, no person may operate to or from an airport in the United States any subsonic airplane...

14 CFR 91.805 - Final compliance: Subsonic airplanes.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Final compliance: Subsonic airplanes. 91... § 91.805 Final compliance: Subsonic airplanes. Except as provided in §§ 91.809 and 91.811, on and after January 1, 1985, no person may operate to or from an airport in the United States any subsonic airplane...

14 CFR 91.805 - Final compliance: Subsonic airplanes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Final compliance: Subsonic airplanes. 91... § 91.805 Final compliance: Subsonic airplanes. Except as provided in §§ 91.809 and 91.811, on and after January 1, 1985, no person may operate to or from an airport in the United States any subsonic airplane...

Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus.

PubMed

Grönwall, Caroline; Reynolds, Harmony; Kim, June K; Buyon, Jill; Goldberg, Judith D; Clancy, Robert M; Silverman, Gregg J

2014-07-01

Noninvasive carotid measurements have proven value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgM anti-PC, as well as lower levels of the ratio of IgM anti-PC/total IgM, compared to patients without plaque (p=0.004 and p=0.02, respectively). The IgM anti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgM anti-PC/total IgM was better for predicting plaque than either test alone. These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirm the utility of IgM anti-PC levels as a biomarker for subclinical CV disease. Copyright © 2014 Elsevier Inc. All rights reserved.

KSC-98pc688

NASA Image and Video Library

1998-06-02

KENNEDY SPACE CENTER, Fla. -- Some of Florida's natural foliage stands silent sentinel to the lift off of the Space Shuttle Discovery from Launch Pad 39A at 6:06:24 p.m. EDT June 2. On board Discovery are Mission Commander Charles J. Precourt; Pilot Dominic L. Gorie; and Mission Specialists Wendy B. Lawrence, Franklin R. Chang-Diaz, Janet Lynn Kavandi and Valery Victorovitch Ryumin. The nearly 10-day mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for the Space Shuttle orbiter Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will be returning to Earth as a STS-91 crew member after living more than four months aboard Mir

KSC-98pc684

NASA Image and Video Library

1998-06-02

KENNEDY SPACE CENTER, Fla. -- The Space Coast's natural foliage frames the Space Shuttle Discovery and the reflection of the intense heat and light of its liftoff from Launch Pad 39A at 6:06:24 p.m. EDT June 2. On board Discovery are Mission Commander Charles J. Precourt; Pilot Dominic L. Gorie; and Mission Specialists Wendy B. Lawrence, Franklin R. Chang-Diaz, Janet Lynn Kavandi and Valery Victorovitch Ryumin. The nearly 10-day mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for the Space Shuttle orbiter Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will be returning to Earth as an STS-91 crew member after living more than four months aboard Mir

KSC-98pc683

NASA Image and Video Library

1998-06-02

KENNEDY SPACE CENTER, Fla. -- Tree branches frame the Space Shuttle Discovery as it lifts off from Launch Pad 39A at 6:06:24 p.m. EDT June 2 on its way to the Mir space station. On board Discovery are Mission Commander Charles J. Precourt; Pilot Dominic L. Gorie; and Mission Specialists Wendy B. Lawrence, Franklin R. Chang-Diaz, Janet Lynn Kavandi and Valery Victorovitch Ryumin. The nearly 10-day mission will feature the ninth and final Shuttle docking with the Russian space station Mir, the first Mir docking for the Space Shuttle orbiter Discovery, the first on-orbit test of the Alpha Magnetic Spectrometer (AMS), and the first flight of the new Space Shuttle super lightweight external tank. Astronaut Andrew S. W. Thomas will be returning to Earth as an STS-91 crew member after living more than four months aboard Mir

Cost Effective Bioethanol via Acid Pretreatment of Corn Stover, Saccharification, and Conversion via a Novel Fermentation Organism: Cooperative Research and Development Final Report, CRADA Number: CRD-12-485

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dowe, N.

2014-05-01

This research program will convert acid pretreated corn stover to sugars at the National Renewable Energy Laboratory (NREL) and then transfer these sugars to Honda R&D and its partner the Green Earth Institute (GEI) for conversion to ethanol via a novel fermentation organism. In phase one, NREL will adapt its pretreatment and saccharification process to the unique attributes of this organism, and Honda R&D/GEI will increase the sugar conversion rate as well as the yield and titer of the resulting ethanol. In later phases, NREL, Honda R&D, and GEI will work together at NREL to optimize and scale-up to pilot-scalemore » the Honda R&D/GEI bioethanol production process. The final stage will be to undertake a pilot-scale test at NREL of the optimized bioethanol conversion process.« less

Evidence for azimuthal variations of the oxygen-abundance gradient tracing the spiral structure of the galaxy HCG 91c

NASA Astrophysics Data System (ADS)

Vogt, F. P. A.; Pérez, E.; Dopita, M. A.; Verdes-Montenegro, L.; Borthakur, S.

2017-05-01

Context. The distribution of elements in galaxies forms an important diagnostic tool to characterize these systems' formation and evolution. This tool is, however, complex to use in practice, as galaxies are subject to a range of simultaneous physical processes active from pc to kpc scales. This renders observations of the full optical extent of galaxies down to sub-kpc scales essential. Aims: Using the WiFeS integral field spectrograph, we previously detected abrupt and localized variations in the gas-phase oxygen abundance of the spiral galaxy HCG 91c. Here, we follow-up on these observations to map HCG 91c's disk out to 2 Re at a resolution of 600 pc, and characterize the non-radial variations of the gas-phase oxygen abundance in the system. Methods: We obtained deep MUSE observations of the target under 0.6 arcsec seeing conditions. We perform both a spaxel-based and aperture-based analysis of the data to map the spatial variations of 12 +log (O/H) across the disk of the galaxy. Results: We confirm the presence of rapid variations of the oxygen abundance across the entire extent of the galaxy previously detected with WiFeS, for all azimuths and radii. The variations can be separated in two categories: a) localized and associated with individual H II regions; and b) extended over kpc scales, and occurring at the boundaries of the spiral structures in the galaxy. Conclusions: Our MUSE observations suggest that the enrichment of the interstellar medium in HGC 91c has proceeded preferentially along spiral structures, and less efficiently across them. Our dataset highlights the importance of distinguishing individual star-forming regions down to scales of a few 100 pc when using integral field spectrographs to spatially resolve the distribution of oxygen abundances in a given system, and accurately characterize azimuthal variations and intrinsic scatter. The movie associated to Fig. 8 is available at http://www.aanda.org

Identification and functional characterization of an uncharacterized antimicrobial peptide from a ciliate Paramecium caudatum.

PubMed

Cui, Pengfei; Dong, Yuan; Li, Zhijian; Zhang, Yubo; Zhang, Shicui

2016-07-01

The global ever-growing concerns about multi-drug resistant (MDR) microbes leads to urgent demands for exploration of new antibiotics including antimicrobial peptides (AMPs). Here we demonstrated that a cDNA from Ciliata Paramecium caudatum, designated Pcamp1, coded for a protein with features characteristic of AMPs, which is not homologous to any AMPs currently known. Both the C-terminal 91 amino acid residues of PcAMP1, cPcAMP1, expressed in Escherichia coli and the C-terminal 26 amino acid residues (predicted mature AMP), cPcAMP1/26, synthesized, underwent a coil-to-helix transition in the presence of TFE, SDS or DPC. Functional assays revealed that cPcAMP1 and cPcAMP1/26 were both able to kill Aeromonas hydrophila and Staphylococcus aureus. ELISA showed that cPcAMP1 and cPcAMP1/26 were able to bind to microbe-associated molecular pattern molecules LPS and LTA, which was further corroborated by the observations that cPcAMP1 could deposit onto the bacterial membranes. Importantly, both cPcAMP1 and cPcAMP1/26 were able to induce bacterial membrane permeabilization and depolarization, and to increase intracellular ROS levels. Additionally, cPcAMP1 and cPcAMP1/26 were not cytotoxic to mammalian cells. Taken together, our results show that PcAMP1 is a potential AMP with a membrane selectivity towards bacterial cells, which renders it a promising template for the design of novel peptide antibiotics against MDR microbes. It also shows that use of signal conserved sequence of AMPs can be an effective tool to identify potential AMPs across different animal classes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Could machine learning improve the prediction of pelvic nodal status of prostate cancer patients? Preliminary results of a pilot study.

PubMed

De Bari, B; Vallati, M; Gatta, R; Simeone, C; Girelli, G; Ricardi, U; Meattini, I; Gabriele, P; Bellavita, R; Krengli, M; Cafaro, I; Cagna, E; Bunkheila, F; Borghesi, S; Signor, M; Di Marco, A; Bertoni, F; Stefanacci, M; Pasinetti, N; Buglione, M; Magrini, S M

2015-07-01

We tested and compared performances of Roach formula, Partin tables and of three Machine Learning (ML) based algorithms based on decision trees in identifying N+ prostate cancer (PC). 1,555 cN0 and 50 cN+ PC were analyzed. Results were also verified on an independent population of 204 operated cN0 patients, with a known pN status (187 pN0, 17 pN1 patients). ML performed better, also when tested on the surgical population, with accuracy, specificity, and sensitivity ranging between 48-86%, 35-91%, and 17-79%, respectively. ML potentially allows better prediction of the nodal status of PC, potentially allowing a better tailoring of pelvic irradiation.

10 CFR 51.91 - Final environmental impact statement-contents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Final environmental impact statement-contents. 51.91... Implementing Section 102(2) Final Environmental Impact Statements-General Requirements § 51.91 Final environmental impact statement—contents. (a)(1) The final environmental impact statement will include responses...

Analysis and Design of a Fiber-optic Probe for DNA Sensors Final Report CRADA No. TSB-1147-95

DOE Office of Scientific and Technical Information (OSTI.GOV)

Molau, Nicole; Vail, Curtis

In 1995, a challenge in the field of genetics dealt with the acquisition of efficient DNA sequencing techniques for reading the 3 billion base-pairs that comprised the human genome. AccuPhotonics, Inc. proposed to develop and manufacture a state-of-the-art near-field scanning optical microscopy (NSOM) fiber-optic probe that was expected to increase probe efficiency by two orders of magnitude over the existing state-of-the-art and to improve resolution to 10Å. The detailed design calculation and optimization of electrical properties of the fiber-optic probe tip geometry would be performed at LLNL, using existing finite-difference time-domain (FDTD) electromagnetic (EM) codes.

Mosaic Transparent Armor System Final Report CRADA No. TC02162.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuntz, J. D.; Breslin, M.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and The Protective Group, Inc. (TPG) to improve the performance of the mosaic transparent armor system (MTAS) for transparent armor applications, military and civilian. LLNL was to provide the unique MTAS technology and designs to TPG for innovative construction and ballistic testing of improvements needed for current and near future application of the armor windows on vehicles and aircraft. The goal of the project was to advance the technology of MTAS to the point that these mosaic transparent windowsmore » would be introduced and commercially manufactured for military vehicles and aircraft.« less

Equipment Loan for Concentrated PV Cavity Converter (PVCC) Research: Cooperative Research and Development Final Report, CRADA Number CRD-08-285

DOE Office of Scientific and Technical Information (OSTI.GOV)

Netter, Judy

2015-07-28

Interest in High Concentration Photovoltaics (HCPV) for terrestrial applications has significantly grown in recent years. A major driver behind this growth trend is the availability of high efficiency multi-junction (MJ) cells that promise reliable operation under high concentrations (500 to 1000 suns). The primary impact of HCPV on the solar electricity cost is the dramatic reduction in cell cost. For terrestrial HCPV systems, operating at concentrations ≥ 500 suns, the expensive MJ cells are marginally affordable. Most recently, triple-junction test cells have achieved a conversion efficiency of over 40% under concentrated sunlight. Photovoltaic Cavity Converter (PVCC) is a multi-bandgap, highmore » concentration PV device developed by United Innovations, Inc., under subcontract to NREL. The lateral- (2- dimensional) structure of PVCC, as opposed to vertical multi-junction (MJ) structure, helps to circumvent most of the developmental challenges MJ technology has yet to overcome. This CRADA will allow the continued development of this technology by United Innovations. This project was funded by the California Energy Commission and is the second phase of a twopart demonstration program. The key advantage of the design was the use of a PVCC as the receiver. PVCCs efficiently process highly concentrated solar radiation into electricity by recycling photons that are reflected from the surface of the cells. Conventional flat, twodimensional receivers cannot recycle photons and the reflected photons are lost to the conversion process.« less

Clinical usefulness of novel tag-less Agile patency capsule prior to capsule endoscopy for patients with suspected small bowel stenosis.

PubMed

Nakamura, Masanao; Hirooka, Yoshiki; Yamamura, Takeshi; Miyahara, Ryoji; Watanabe, Osamu; Ando, Takafumi; Ohmiya, Naoki; Goto, Hidemi

2015-01-01

The Agile patency capsule (PC; Given Imaging Ltd, Yoqneam, Israel) is used as a dummy prior to capsule endoscopy (CE) to avoid retention of the CE capsule. However, impaction of the PC's inner radio frequency identification (RFID) tag in a stricture could cause small-bowel ileus. Recently, the RFID tag-less PC was introduced into clinical practice. Herein, we aimed to retrospectively evaluate the usefulness of the tag-less PC. Of 154 patients who were scheduled to undergo CE, 100 consecutive patients (65%) who underwent PC evaluation were enrolled in the present study. Primary study end point was the retention rate of the CE capsule after successful passage of the PC. Secondary end point was analysis of the significant factors affecting the passage of the PC. In total, 87 patients (87%) had bowel patency confirmed by PC evaluation. There was no capsule retention in any of these 87 patients during CE. Abnormal findings were obtained from 60 CE, and 41 patients received new or modified treatment. Multivariate analysis of factors related to the confirmation of patency demonstrated that stenosis on imaging was the most influential factor (P = 0.002, odds ratio 16.387). The results confirmed that passage of the PC depends on stenosis on imaging. Use of the tag-less PC confirmed gastrointestinal tract patency for most of the patients who did not have stenosis on imaging and allowed estimation of the patency for patients who did have stenosis on imaging. © 2014 The Authors. Digestive Endoscopy © 2014 Japan Gastroenterological Endoscopy Society.

Serum Immunoglobulin G4 in Discriminating Autoimmune Pancreatitis From Pancreatic Cancer: A Diagnostic Meta-analysis.

PubMed

Dai, Cong; Cao, Qin; Jiang, Min; Sun, Ming-Jun

2018-03-01

Differentiation between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) is a clinical challenge. Emerging published data on the accuracy of serum immunoglobulin G4 (IgG4) for the differential diagnosis between AIP and PC are inconsistent. The objective of our study was to perform a meta-analysis evaluating the clinical utility of serum IgG4 in the differential diagnosis between AIP and PC. We performed a systematic literature search of multiple electronic databases. The methodological quality of each study was assessed according to the Quality Assessment of Diagnostic Accuracy Studies checklist. Random-effects model was used to summarize the diagnostic odds ratio and other measures of accuracy. Eleven studies comprising 523 AIP patients and 771 PC patients were included in the meta-analysis. The summary estimates for serum IgG4 in distinguishing AIP from PC were as follows: diagnostic odds ratio, 57.30 (95% confidence interval [CI], 23.17-141.67); sensitivity, 0.72 (95% CI, 0.68-0.76); specificity, 0.93 (95% CI, 0.91-0.94). The area under the curve of serum IgG4 in distinguishing AIP from PC was 0.9200. Our meta-analysis found that serum IgG4 has high specificity and relatively low sensitivity in the differential diagnosis between AIP and PC. Therefore, serum IgG4 is useful in distinguishing AIP from PC.

Effect of vitamin E on oxidative stress in the contralateral testis of neonatal and pubertal hemicastrated rats.

PubMed

Han, Woong Kyu; Jin, Mei Hua; Han, Sang Won

2012-02-01

To evaluate whether the antioxidant vitamin E can prevent the harmful effects of reactive oxidative stress (ROS) that occur during compensatory testicular hypertrophy (CTH). Thirty Sprague-Dawley rats were divided into six equal groups: neonatal hemicastrated vitamin E (NH_Vit E/NH) and sham surgical controls (NC), and pubertal hemicastrated vitamin E (PH_Vit E/PH) and sham surgical controls (PC). Vitamin E was administered orally to the NH_Vit E and PH_Vit E groups three times a week from week 3-12 prior to sacrifice. Antioxidant enzymes were measured in testis samples from each animal. Differences in superoxide dismutase activity were observed between the NH (21.04 ± 0.48) and NH_Vit E (22.62 ± 0.64) groups (P = 0.008); the PH (20.59 ± 0.11) and PC (20.91 ± 0.20) groups (P = 0.032); and the PH (20.59 ± 0.11) and PH_Vit E (22.32 ± 1.01) groups (P = 0.008). Thiobarbituric acid-reactive substance in the PH and PH_Vit E groups was 0.097 ± 0.022 and 0.036 ± 0.004 (P = 0.008), respectively; and in the NH and NH_Vit E groups it was 0.135 ± 0.02 and 0.039 ± 0.003 (P = 0.008), respectively. These results suggest that CTH is not associated with reducing oxidative injury, nor does it prevent ROS-induced cell damage. However, administration of vitamin E does reduce oxidative injury and prevent ROS-induced cell damage in a hemicastrated rat model. Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

A critical note on the IAGA-endorsed Polar Cap (PC) indices: excessive excursions in the real-time index values

NASA Astrophysics Data System (ADS)

Stauning, Peter

2018-04-01

The Polar Cap (PC) indices were approved by the International Association for Geomagnetism and Aeronomy (IAGA) in 2013 and made available at the web portal http://pcindex.org holding prompt (real-time) as well as archival index values. The present note provides the first reported examination of the validity of the IAGA-endorsed method to generate real-time PC index values. It is demonstrated that features of the derivation procedure defined by Janzhura and Troshichev (2011) may cause considerable excursions in the real-time PC index values compared to the final index values. In examples based on occasional downloads of index values, the differences between real-time and final values of PC indices were found to exceed 3 mV m-1, which is a magnitude level that may indicate (or hide) strong magnetic storm activity.

78 FR 17865 - Airworthiness Directives; PILATUS AIRCRAFT LTD. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-25

... TBO were moved from Chapter 5: Time Limits/Maintenance Checks, to Chapter 4: Structural, Component and... Directives; PILATUS AIRCRAFT LTD. Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final... all PILATUS AIRCRAFT LTD. Models PC-12, PC-12/45, and PC-12/47 airplanes. This AD results from...

Molecular imprinting ratiometric fluorescence sensor for highly selective and sensitive detection of phycocyanin.

PubMed

Wang, Xiaoyan; Yu, Jialuo; Kang, Qi; Shen, Dazhong; Li, Jinhua; Chen, Lingxin

2016-03-15

A facile strategy was developed to prepare molecular imprinting ratiometric fluorescence sensor for highly selective and sensitive detection of phycocyanin (PC) based on fluorescence resonance energy transfer (FRET), via a sol-gel polymerization process using nitrobenzoxadiazole (NBD) as fluorescent signal source. The ratio of two fluorescence peak emission intensities of NBD and PC was utilized to determine the concentration of PC, which could effectively reduce the background interference and fluctuation of diverse conditions. As a result, this sensor obtained high sensitivity with a low detection limit of 0.14 nM within 6 min, and excellent recognition specificity for PC over its analogues with a high imprinting factor of 9.1. Furthermore, the sensor attained high recoveries in the range of 93.8-110.2% at three spiking levels of PC, with precisions below 4.7% in seawater and lake water samples. The developed sensor strategy demonstrated simplicity, reliability, rapidity, high selectivity and high sensitivity, proving to be a feasible way to develop high efficient fluorescence sensors and thus potentially applicable for ultratrace analysis of complicated matrices. Copyright © 2015 Elsevier B.V. All rights reserved.

A novel matrix dispersion based on phospholipid complex for improving oral bioavailability of baicalein: preparation, in vitro and in vivo evaluations.

PubMed

Zhou, Yang; Dong, Wujun; Ye, Jun; Hao, Huazhen; Zhou, Junzhuo; Wang, Renyun; Liu, Yuling

2017-11-01

Phospholipid complex is one of the most successful approaches for enhancing oral bioavailability of poorly absorbed plant constituents. But the sticky property of phospholipids results in an unsatisfactory dissolution of drugs. In this study, a matrix dispersion of baicalein based on phospholipid complex (BaPC-MD) was first prepared by a discontinuous solvent evaporation method, in which polyvinylpyrrolidone-K30 (PVP-K30) was employed for improving the dispersibility of baicalein phospholipid complex (BaPC) and increasing dissolution of baicalein. The combination ratio of baicalein and phospholipids in BaPC-MD was 99.39% and baicalein was still in a complete complex state with phospholipid in BaPC-MD. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier Transform Infrared (FTIR) analyzes demonstrated that baicalein was fully transformed to an amorphous state in BaPC-MD and phospholipid complex formed. The water-solubility and n-octanol solubility of baicalein in BaPC-MD significantly increased compared with those of pure baicalein. Compared with baicalein and BaPC, the cumulative dissolution of BaPC-MD at 120 min increased 2.77- and 1.23-fold, respectively. In vitro permeability study in Caco-2 cells indicated that the permeability of BaPC-MD was remarkably higher than those of baicalein and BaPC. Pharmacokinetic study showed that the average C max of BaPC-MD was significantly increased compared to baicalein and BaPC. AUC 0-14 h of BaPC-MD was 5.01- and 1.91-fold of baicalein and BaPC, respectively. The novel BaPC-MD significantly enhanced the oral bioavailability of baicalein by improving the dissolution and permeability of baicalein without destroying the complexation state of baicalein and phospholipids. The current drug delivery system provided an optimal strategy to significantly enhance oral bioavailability for poorly water-soluble drugs.

KSC-98pc694

NASA Image and Video Library

1998-06-02

STS-91 Mission Commander Charles J. Precourt gets help with his flight gear from white room crew members Jean Alexander and Greg Lohning as he prepares to enter the Space Shuttle Discovery at Launch Pad 39A. White room crew member Dave Law is in the foreground

Fabricating photoswitches and field-effect transistors from self-assembled tetra(2-isopropyl-5-methyphenoxy) copper phthalocyanines nanowires.

PubMed

Cheng, Chuanwei; Gao, Junshan; Xu, Guoyue; Zhang, Haiqian; Li, Yingying; Luo, Yan

2009-05-01

Tetra(2-isopropyl-5-methyphenoxy) copper phthalocyanine (CuPc) nanowires synthesized by a facile, low temperature self-assembled route, were incorporated into nano-devices: photoswitch and organic field-effect transistor. The devices were capable of switching on/off reversibly and fast by turning the 808 nm infrared light on/off. And the carrier mobility micro of CuPc nanowires incorporated in the devices was -0.02 cm2/V x s. The prelimenary results in this study show the potential application of metal phthalocyanine nanowires in low-cost fabrication of nano photo-electric devices.

Retinal Nerve Fiber Layer and Peripapillary Choroidal Thicknesses in Non-Glaucomatous Unilateral Optic Atrophy Compared with Unilateral Advanced Pseudoexfoliative Glaucoma.

PubMed

Kucukevcilioglu, Murat; Ayyildiz, Onder; Aykas, Seckin; Gokce, Gokcen; Koylu, Mehmet Talay; Ozgonul, Cem; Ozge, Gokhan; Mumcuoglu, Tarkan; Yumusak, Erhan

2017-02-01

To investigate retinal nerve fiber layer thickness (RNFL-T) and peripapillary choroidal thickness (PC-T) in non-glaucomatous optic atrophy (OA) patients in comparison with unaffected and control eyes, furthermore, to compare thickness profiles with unilateral pseudoexfoliative advanced glaucoma. Thirty-three eyes with OA (Group A), 33 unaffected fellow eyes (Group B), 25 right eyes of 25 control subjects (Group C), and 15 eyes with advanced glaucoma (Group D) were enrolled. RNFL-T was measured in six regions by spectral-domain optical coherence tomography. Enhanced depth imaging optical coherence tomography was obtained to evaluate PC-T in corresponding regions. RNFL-T was significantly lower in Group A than in Groups B and C globally and at all peripapillary regions (all p < 0.001). P-CT in Group A was significantly lower globally (p = 0.03) and in three regions (temporal, p = 0.001; temporal-superior, p = 0.01; and nasal-inferior, p = 0.037) versus Group C. However, it was significantly thinner than in Group B in all regions (temporal, p = 0.02; temporal-superior, p = 0.013; nasal-superior, p = 0.044; nasal, p = 0.02; nasal-inferior, p < 0.001; and temporal-inferior, p < 0.001) and globally (p < 0.001). In Group A RNFL-T (thicker superiorly and inferiorly; thinner temporally and nasally) and PC-T (superior > temporal > nasal > inferior) profiles were almost identical to that in unaffected fellow eyes and control eyes. However, Group D showed different patterns with less regional differences in RNFL-T, and the greatest value of PC-T in nasal quadrant. Besides retinal nerve fiber layer thinning, non-glaucomatous OA is associated with choroidal thinning. The RNFL-T and PC-T profiles in advanced glaucoma eyes differed from the common patterns seen among OA eyes, unaffected fellow eyes, and control eyes.

14 CFR 91.853 - Final compliance: Civil subsonic airplanes.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Final compliance: Civil subsonic airplanes... Noise Limits § 91.853 Final compliance: Civil subsonic airplanes. Except as provided in § 91.873, after... airplane subject to § 91.801(c) of this subpart, unless that airplane has been shown to comply with Stage 3...

14 CFR 91.853 - Final compliance: Civil subsonic airplanes.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Final compliance: Civil subsonic airplanes... Noise Limits § 91.853 Final compliance: Civil subsonic airplanes. Except as provided in § 91.873, after... airplane subject to § 91.801(c) of this subpart, unless that airplane has been shown to comply with Stage 3...

14 CFR 91.853 - Final compliance: Civil subsonic airplanes.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Final compliance: Civil subsonic airplanes... Noise Limits § 91.853 Final compliance: Civil subsonic airplanes. Except as provided in § 91.873, after... airplane subject to § 91.801(c) of this subpart, unless that airplane has been shown to comply with Stage 3...

14 CFR 91.853 - Final compliance: Civil subsonic airplanes.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Final compliance: Civil subsonic airplanes... Noise Limits § 91.853 Final compliance: Civil subsonic airplanes. Except as provided in § 91.873, after... airplane subject to § 91.801(c) of this subpart, unless that airplane has been shown to comply with Stage 3...

14 CFR 91.853 - Final compliance: Civil subsonic airplanes.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Final compliance: Civil subsonic airplanes... Noise Limits § 91.853 Final compliance: Civil subsonic airplanes. Except as provided in § 91.873, after... airplane subject to § 91.801(c) of this subpart, unless that airplane has been shown to comply with Stage 3...

Prostate cancer-related anxiety in long-term survivors after radical prostatectomy.

PubMed

Meissner, Valentin H; Herkommer, Kathleen; Marten-Mittag, Birgitt; Gschwend, Jürgen E; Dinkel, Andreas

2017-12-01

Knowledge of the psychological distress of long- and very long-term (>10 years) prostate cancer (PC) survivors is limited. This study intended to examine the parameters influencing anxiety related to prostate-specific antigen (PSA) and PC in long-term survivors after radical prostatectomy. We surveyed 4719 PC survivors from the German multicenter prospective database "Familial Prostate Cancer." We evaluated the association of PC-related anxiety (MAX-PC) with sociodemographic characteristics, family history of PC, global health status/quality of life (EORTC QLQ-C30), depression and anxiety (PHQ-2; GAD-2), latest PSA level, time since radical prostatectomy, and current therapy. The survey participants' mean age was 75.2 years (SD = 6.5). Median follow-up was 11.5 years, and 19.5% of participants had survived more than 15 years since the initial treatment. The final regression analysis found that younger age, lower global health status/quality of life, higher depression and anxiety scores, higher latest PSA level, and shorter time since radical prostatectomy predicted increased PSA-related anxiety and PC anxiety. Familial PC was predictive only of PSA anxiety (all p < 0.05). The final model explained 12% of the variance for PSA anxiety and 24% for PC anxiety. PC-related anxiety remained relevant many years after prostatectomy and was influenced by younger age, psychological status, rising PSA level, and shorter time since initial treatment. Survivors with these characteristics are at increased risk of PC-related anxieties, which should be considered by the treating physician during follow-up.

Partial meniscectomy provides no benefit for symptomatic degenerative medial meniscus posterior root tears.

PubMed

Krych, Aaron J; Johnson, Nick R; Mohan, Rohith; Dahm, Diane L; Levy, Bruce A; Stuart, Michael J

2018-04-01

Medial meniscus posterior root tears (MMPRTs) are recognized as a source of pain and dysfunction, but treatment options remain a challenge. The purpose of the study was to determine (1) the efficacy of partial meniscectomy to treat MMPRTs compared to a matched group of non-operatively treated MMPRTs, and (2) risk factors for worse clinical and radiographic outcome. This retrospective comparative study was performed to include patients with complete, isolated MMPRTs with documented clinical symptoms and were treated with arthroscopic partial meniscectomy (PMM) and a minimum 2-year follow-up. These patients were then matched by age, gender, and BMI to patients with the same diagnosis who were treated non-operatively. Clinical and radiographic outcomes were compared between the two groups. Analysis was performed to determine risk factors for worse clinical and radiographic outcome in the PMM group alone. Overall, 52 patients were included in the study. Twenty-six patients (9M:17F) with a mean age of 55 ± 9 and a mean BMI of 32.8 ± 5.3 were treated with PMM and followed for 5.5 ± 2.0 years (range 2.3-9.3 years). In the PMM group, final median Tegner score was 3, mean IKDC score was 67.8 ± 20, and more patients had grade II or higher arthritis at final follow-up than baseline (91.3 vs. 36%, p < 0.01). Overall, 14 of the 26 patients (54%) treated operatively progressed to total knee arthroplasty at a mean of 54.3 months. There was no significant difference in final Tegner scores, IKDC, K-L grades, progression to arthroplasty, or overall failure rate between the PMM group and non-operative group. Following PMM, female patients had lower final IKDC scores (44.0 ± 2.8 vs. 74.6 ± 16.7, p = 0.02) compared to males, as well as a higher rate of arthroplasty (70.6 vs. 20.0%, p = 0.009). Higher BMI correlated with lower IKDC scores (r = -0.91, p = 0.01) and meniscal extrusion was associated with higher rate of arthritis at final follow-up (p = 0.02). Partial meniscectomy for a complete MMPRT provides no benefit in halting arthritic progression. Patients who undergo PMM for MMPRTs still progress to significant arthritis, poor clinical outcomes and a high arthroplasty rate (54%) at over 5-year follow-up. Female gender, increased BMI, and meniscus extrusion were associated with worse outcome. Level III.

APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.

PubMed

Mata, Ignacio F; Leverenz, James B; Weintraub, Daniel; Trojanowski, John Q; Hurtig, Howard I; Van Deerlin, Vivianna M; Ritz, Beate; Rausch, Rebecca; Rhodes, Shannon L; Factor, Stewart A; Wood-Siverio, Cathy; Quinn, Joseph F; Chung, Kathryn A; Peterson, Amie L; Espay, Alberto J; Revilla, Fredy J; Devoto, Johnna; Hu, Shu-Ching; Cholerton, Brenna A; Wan, Jia Y; Montine, Thomas J; Edwards, Karen L; Zabetian, Cyrus P

2014-11-01

Cognitive impairment is a common and disabling problem in Parkinson disease (PD) that is not well understood and is difficult to treat. Identification of genetic variants that influence the rate of cognitive decline or pattern of early cognitive deficits in PD might provide a clearer understanding of the etiopathogenesis of this important nonmotor feature. To determine whether common variation in the APOE, MAPT, and SNCA genes is associated with cognitive performance in patients with PD. We studied 1079 PD patients from 6 academic centers in the United States who underwent assessments of memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), attention and executive function (Letter-Number Sequencing Test and Trail Making Test), language processing (semantic and phonemic verbal fluency tests), visuospatial skills (Benton Judgment of Line Orientation test), and global cognitive function (Montreal Cognitive Assessment). Participants underwent genotyping for the APOE ε2/ε3/ε4 alleles, MAPT H1/H2 haplotypes, and SNCA rs356219. We used linear regression to test for association between genotype and baseline cognitive performance with adjustment for age, sex, years of education, disease duration, and site. We used a Bonferroni correction to adjust for the 9 comparisons that were performed for each gene. Nine variables derived from 7 psychometric tests. The APOE ε4 allele was associated with lower performance on the HVLT-R Total Recall (P = 6.7 × 10(-6); corrected P [Pc] = 6.0 × 10(-5)), Delayed Recall (P = .001; Pc = .009), and Recognition Discrimination Index (P = .004; Pc = .04); a semantic verbal fluency test (P = .002; Pc = .02); the Letter-Number Sequencing Test (P = 1 × 10(-5); Pc = 9 × 10(-5)); and Trail Making Test B minus Trail Making Test A (P = .002; Pc = .02). In a subset of 645 patients without dementia, the APOE ε4 allele was associated with lower scores on the HVLT-R Total Recall (P = .005; Pc = .045) and the semantic verbal fluency (P = .005; Pc = .045) measures. Variants of MAPT and SNCA were not associated with scores on any tests. Our data indicate that the APOE ε4 allele is an important predictor of cognitive function in PD across multiple domains. Among PD patients without dementia, the APOE ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD.

49 CFR Appendix D to Part 222 - Determining Risk Levels

Code of Federal Regulations, 2011 CFR

2011-10-01

... prediction formulas can be used to derive the following for each crossing: 1. the predicted collisions (PC) 2... for errors such as data entry errors. The final output is the predicted number of collisions (PC). (e... collisions (PC). (f) For the prediction and severity index formulas, please see the following DOT...

KSC-91PC-0219

NASA Image and Video Library

1990-12-20

CAPE CANAVERAL, Fla. – The orbiter Discovery, its wheels retracted atop the orbiter transporter, rolls over from the OPF high bay to the VAB. Discovery is slated to lift off in March on mission STS-39, a DoD flight carrying a crew of seven. Photo credit: NASA

Revealing the Galactic Center in the Far-Infrared with SOFIA/FORCAST

NASA Astrophysics Data System (ADS)

Lau, Ryan M.; Herter, Terry; Morris, Mark; Li, Zhiyuan; Becklin, Eric; Adams, Joseph; Hankins, Matthew

2015-08-01

We present a summary of far-infrared imaging observations of the inner 40 pc of the Galactic center addressing the dense, dusty torus around Sgr A*, massive star formation, and dust production around massive stars and in the Sgr A East supernova remnant. Observations of warm dust emission were performed using the Faint Object Infrared Camera for the SOFIA Telescope (FORCAST). The Circumnuclear Ring (CNR) surrounding and heated by central cluster in the vicinity of Sgr A* shows no internal active star formation but does exhibit significant density “clumps,” a surprising result because tidal shearing should act quickly to smear out structure. G-0.02-0.07, a complex consisting of three compact HII regions and one ultracompact HII region, is site of the most recent confirmed star formation within ~10 pc of the Galactic center. Our observations reveal the dust morphologies and SEDs of the regions to constrain the composition and gas-to-dust mass ratios of the emitting dust and identify heating sources candidates from archival near-IR images. FORCAST observations Luminous Blue Variables (LBVs) located in and near the Quintuplet Cluster reveal the asymmetric, compressed shell of hot dust surrounding the Pistol Star and provide the first detection of the thermal emission from the symmetric, hot dust envelope surrounding G0.120-0.048. These two LBV’s have nebulae with similar quantities of dust (~0.02 M⊙) but exhibit contrasting appearances due to the external influence of their different environments. Finally, the far-infrared observations indicate the presence of ~0.02 M⊙ of warm (~100 K) dust in the hot interior of the ~10,000 yr-old SgrA East supernova remnant indicating the dust has survived the passage of the reverse shock. The results suggest that supernovae may indeed be the dominant dust production mechanism in the dense environment of early Universe galaxies.

The design of PC/MISI, a PC-based common user interface to remote information storage and retrieval systems. Presentation visuals. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Hall, Philip P.

1985-01-01

This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled, The Design of PC/MISI, a PC-Based Common User Interface to Remote Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-15. The paper discusses the following: problem definition; the PC solution; the goals of system design; the design description; future considerations, the research environment; conclusions.

The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients.

PubMed

Vargas-Alarcón, Gilberto; Cruz-López, Miguel; Valladares, Adán; Álvarez-León, Edith; Juárez-Cedillo, Teresa; Pérez-Méndez, Óscar; de-la-Peña, Jorge Escobedo; Escobedo, Galileo; Fragoso, Jose Manuel

2015-11-01

Silent myocardial ischemia (SMI) is a multifactorial and polygenic disorder that results from an excessive inflammatory response. Considering the prominent role of IL-1β, IL-1F10 and IL-1RN as regulators of the inflammatory process and vascular physiology, the aim of the present study was to analyze whether IL-1β, IL-1F10 and IL-1RN single nucleotide polymorphisms (SNPs) are associated with SMI. One polymorphism was associated with risk of SMI. Under co-dominant, recessive and additive models, the IL-1β-511 T>C polymorphism was associated with increased risk of SMI when compared to healthy controls (OR=4.68, 95%CI=2.21-9.92, pCCo-dom=0.0048; OR=3.97, 95%CI=1.97-7.99, pCRec=0.0024; OR=2.02, 95%CI=1.41-2.90, pCAdd=0.0024, respectively). All models were adjusted for gender, age and smoking. Linkage disequilibrium analysis showed four haplotypes (CTCC, CCTC, CCCT and CTCC) with increased frequency in SMI patients when compared to healthy controls (OR=2.53, 95%CI=1.47-4.36, pC=0.0009, OR=2.34, 95%CI=1.15-4.74, pC=0.02, OR=2.44, 95%CI=1.14-5.18, pC=0.02, OR=5.11, 95%CI=1.37-19.05, pC=0.01, respectively). In summary, our data suggest that the IL-1β-511 T>C polymorphism plays an important role in the development of SMI in diabetic patients. In addition, in our study was possible to distinguish one protective and four risk haplotypes for development of SMI. Copyright © 2015 Elsevier B.V. All rights reserved.

Community Energy Storage Thermal Analysis and Management: Cooperative Research and Development Final Report, CRADA Number CRD-11-445

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Kandler A.

The goal of this project is to create thermal solutions and models for community energy storage devices using both purpose-designed batteries and EV or PHEV batteries. Modeling will be employed to identify major factors of a device's lifetime and performance. Simultaneously, several devices will be characterized to determine their electrical and thermal performance under controlled conditions. After the factors are identified, a variety of thermal design approaches will be evaluated to improve the performance of energy storage devices. Upon completion of this project, recommendations for community energy storage device enclosures, thermal management systems, and/or battery sourcing will be made. NREL'smore » interest is in both new and aged batteries.« less

Phase II: Automated System for Aneuploidy Detection in Sperm Final Report CRADA No. TC-1554-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wyrobek, W. J.; Dunlay, R. T.

This was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and Cellomics, Inc. (formerly BioDx and Biological Detection, Inc.) to develop an automated system for detecting human sperm aneuploidy. Aneuploidy (an abnormal number of chromosomes) is one of the major categories of chromosomally abnormal sperm, which results in chromosomally defective pregnancies and babies. An automated system would be used for testing the effects of toxic agents and for other research and clinical applications. This collaborated effort was funded by a National Institutes of Environmental Health Services, Phase II, Small Business Innovation Research Program (SBIR) grantmore » to Cellornics (Contract No. N44-ES-82004).« less

Effect of moisture on the physical and durability properties of methyl methacrylate polymer concrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fontana, J.J.; Reams, W.

1983-01-01

The compressive strength of methyl methacrylate PC composites decays very rapidly as the moisture content of the coarse aggregate is increased from 0 to 1 wt %. The durability of the PC also shows evidence of decay. Addition of silane coupling agent, such as A-1120, to the monomer component of a PC composite increases the compressive strength of such composites made with moist coarse aggregates. The compressive strengths of such PC composites are as high as a normal PCC used in highway applications. The durability of PC composites made with a silane additive seems to increase as the composite undergoesmore » freeze-thaw cycling which reinforces the justification that such materials can be used for PCC repairs without a sacrifice in use lifespans. However, for the convenience of using moist aggregates, one must endure the additional cost of the silane coupling agent. If it costs more than $0.02/lb to dry the aggregate, and one is willing to accept the reduced strengths associated with moist aggregates, then the use of a silane coupling agent can be cost effective. 3 figures, 4 tables.« less

Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes

PubMed Central

Langeberg, Wendy J.; Kwon, Erika M.; Koopmeiners, Joseph S.; Ostrander, Elaine A.; Stanford, Janet L.

2009-01-01

Background Mismatch repair (MMR) gene activity may be associated with prostate cancer (PC) risk and outcomes. This study evaluated whether single nucleotide polymorphisms (SNPs) in key MMR genes are related to PC outcomes. Methods Data from two population-based case-control studies of PC among Caucasian and African-American men residing in King County, Washington were combined for this analysis. Cases (n=1,458) were diagnosed with PC in 1993–96 or 2002–05 and identified via the Seattle-Puget Sound SEER cancer registry. Controls (n=1,351) were age-matched to cases and identified via random digit dialing. Logistic regression was used to assess the relationship between haplotype-tagging SNPs and PC risk and disease aggressiveness. Cox proportional hazards regression was used to assess the relationship between SNPs and PC recurrence and PC-specific death. Results Nineteen SNPs were evaluated in the key MMR genes: five in MLH1, 10 in MSH2, and 4 in PMS2. Among Caucasian men, one SNP in MLH1 (rs9852810) was associated with: overall PC risk (OR=1.21, 95% CI=1.02, 1.44; p=0.03), more aggressive PC (OR=1.49, 95% CI=1.15–1.91; p<0.01), and PC recurrence (HR=1.83, 95% CI=1.18, 2.86; p<0.01), but not PC-specific mortality. A non-synonymous coding SNP in MLH1, rs1799977 (I219V), was also found to be associated with more aggressive disease. These results did not remain significant after adjusting for multiple comparisons. Conclusion This population-based case-control study provides evidence for a possible association with a gene variant in MLH1 in relation to risk of overall PC, more aggressive disease, and PC recurrence, which warrants replication. PMID:20056646

KSC-98pc695

NASA Image and Video Library

1998-06-02

STS-91 Mission Specialist Janet Lynn Kavandi gets some help with her flight suit from David Brandt in the White Room at Launch Pad 39A. He and white room crew member Greg Lohning will assist Kavandi to enter the Space Shuttle Discovery through the hatch seen in the background

Exploring synchrotron radiation capabilities: The ALS-Intel CRADA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gozzo, F.; Cossy-Favre, A; Trippleet, B.

1997-04-01

Synchrotron radiation spectroscopy and spectromicroscopy were applied, at the Advanced Light Source, to the analysis of materials and problems of interest to the commercial semiconductor industry. The authors discuss some of the results obtained at the ALS using existing capabilities, in particular the small spot ultra-ESCA instrument on beamline 7.0 and the AMS (Applied Material Science) endstation on beamline 9.3.2. The continuing trend towards smaller feature size and increased performance for semiconductor components has driven the semiconductor industry to invest in the development of sophisticated and complex instrumentation for the characterization of microstructures. Among the crucial milestones established by themore » Semiconductor Industry Association are the needs for high quality, defect free and extremely clean silicon wafers, very thin gate oxides, lithographies near 0.1 micron and advanced material interconnect structures. The requirements of future generations cannot be met with current industrial technologies. The purpose of the ALS-Intel CRADA (Cooperative Research And Development Agreement) is to explore, compare and improve the utility of synchrotron-based techniques for practical analysis of substrates of interest to semiconductor chip manufacturing. The first phase of the CRADA project consisted in exploring existing ALS capabilities and techniques on some problems of interest. Some of the preliminary results obtained on Intel samples are discussed here.« less

Transactive Campus Energy Systems: Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katipamula, Srinivas; Corbin, Charles D.; Haack, Jereme N.

Transactive energy refers to the combination of economic and control techniques to improve grid reliability and efficiency. The fundamental purpose of transactive energy management is to seamlessly coordinate the operation of large numbers of new intelligent assets—such as distributed solar, energy storage and responsive building loads—to provide the flexibility needed to operate the power grid reliably and at minimum cost, particularly one filled with intermittent renewable generation such as the Pacific Northwest. It addresses the key challenge of providing smooth, stable, and predictable “control” of these assets, despite the fact that most are neither owned nor directly controlled by themore » power grid. The Clean Energy and Transactive Campus (CETC) work described in this report was done as part of a Cooperative Research and Development Agreement (CRADA) between the U.S. Department of Energy’s Pacific Northwest National Laboratory (PNNL) and the Washington State Department of Commerce (Commerce) through the Clean Energy Fund (CEF). The project team consisted of PNNL, the University of Washington (UW) and Washington State University (WSU), to connect the PNNL, UW, and WSU campuses to form a multi-campus testbed for transaction-based energy management—transactive—solutions. Building on the foundational transactive system established by the Pacific Northwest Smart Grid Demonstration (PNWSGD), the purpose of the project was to construct the testbed as both a regional flexibility resource and as a platform for research and development (R&D) on buildings/grid integration and information-based energy efficiency. This report provides a summary of the various tasks performed under the CRADA.« less

NREL and DONG Energy Collaboration for Grid Simulator Controls and Testing: Cooperative Research and Development Final Report, CRADA Number CRD-13-527

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gevorgian, Vahan

The National Renewable Energy Laboratory (NREL) and DONG Energy are interested in collaborating for the development of control algorithms, modeling, and grid simulator testing of wind turbine generator systems involving NWTC's advanced Controllable Grid Interface (CGI). NREL and DONG Energy will work together to develop control algorithms, models, test methods, and protocols involving NREL's CGI, as well as appropriate data acquisition systems for grid simulation testing. The CRADA also includes work on joint publication of results achieved from modeling and testing efforts. Further, DONG Energy will send staff to NREL on a long-term basis for collaborative work including modeling andmore » testing. NREL will send staff to DONG Energy on a short-term basis to visit wind power sites and participate in meetings relevant to this collaborative effort. DOE has provided NREL with over 10 years of support in developing custom facilities and capabilities to enable testing of full-scale integrated wind turbine drivetrain systems in accordance with the needs of the US wind industry. NREL currently operates a 2.5MW dynamometer and is in the processes of commissioning a 5MW dynamometer and a grid simulator (referred to as a 'Controllable Grid Interface' or CGI). DONG Energy is the market leader in offshore wind power development, with currently over 1 GW of on- and offshore wind power in operation, and 1.3 GW under construction. DONG Energy has on-going R&D projects involving high voltage DC (HVDC) transmission.« less

Assessment of Parylene C Thin Films for Heart Valve Tissue Engineering

PubMed Central

Marei, Isra; Chester, Adrian; Carubelli, Ivan; Prodromakis, Themistoklis; Trantidou, Tatiana

2015-01-01

Background: Scaffolds are a key component of tissue-engineered heart valves (TEHVs). Several approaches had been adopted in the design of scaffolds using both natural and synthetic resources. We have investigated the suitability of parylene C (PC), a vapor deposited polymeric material, for the use as a scaffold in TEHV. Aims: To evaluate the adsorption of extracellular matrix components onto plasma-activated PC and study the biocompatibility of PC by measuring cellular adhesion, viability, apoptosis, and phenotypic expression of valve endothelial and interstitial cells. Finally, the mechanical properties of PC were compared with those of native aortic valve cusp tissue. Methods: PC slides were plasma activated and then coated with gelatin, type I collagen, or fibronectin. Porcine pulmonary valve endothelial and interstitial cells were then grown on plasma oxidized PC with different types of coatings and their adhesion was observed after 20 h of incubation. Cell viability was tested using the MTS assay, and apoptosis was estimated using TUNEL staining. The mechanical properties of PC and valve tissue were measured using a Bose Mechanical Tester. Finally, cell-seeded PC films were exposed to pulsatile pressure and aortic shear stress, respectively, to test their durability in a dynamic environment. Results: Our findings show that collagen and fibronectin could bind to plasma oxidized PC. Both valve endothelial and interstitial cells adhered to protein-coated ECM. PC had a profile of mechanical stiffness and ultimate tensile strength that were comparable with or in excess of those seen in porcine aortic valve cusps. Cells were still attached to PC films after 3 days of exposure to up to 50 mmHg pulsatile pressure or aortic levels of shear stress. Conclusion: PC is a promising candidate for use as a scaffold in tissue engineering heart valves. Additional studies are required to determine both the durability and long-term performance of cell-seeded PC when in a similar hemodynamic environment to that of the aortic valve. PMID:26101808

Pressure Wire Compared to Microcatheter Sensing for Coronary Fractional Flow Reserve: The PERFORM Study.

PubMed

Ali, Ziad A; Parviz, Yasir; Brinkman, Matthew; Matsumura, Mitsuaki; Redfors, Björn; Brogno, David A; Corral, Maria D; Fall, Khady N; Mintz, Gary S; Stone, Gregg W; Maehara, Akiko; Jeremias, Allen; Kirtane, Ajay J

2018-05-15

Among technologies used to assess FFR, a monorail, sensor-tipped micro pressure catheter (PC) may be advantageous for delivery and re-assessment. We sought to determine whether the larger cross-sectional area of the PC influences FFR measurements compared to the pressure wire. PERFORM was a single-center, prospective study designed to determine the precision and accuracy of the PC compared with the pressure wire (PW) for measurement of FFR. Eligible patients had native coronary artery target lesions with visually estimated diameter stenosis of 40-90%. The independently adjudicated primary endpoint was the difference in hyperemic PW-determined minimal FFR with and without the PC distal to the stenosis. Seventy-four patients (95 lesions) were prospectively analyzed between December 2015 and December 2016. Median hyperemic FFR was 0.84 [IQR 0.78, 0.89] with the PW and 0.79 [IQR 0.73, 0.85] with the PC distal to the stenosis (p<0.001). Such differences led to clinical discordance, whereby the PC decreased the hyperemic PW-determined FFR from >0.80 to ≤0.80 in 17 of 95 measurements (19%). Median resting Pd/Pa was lower following introduction of the PC compared with the PW alone (0.93 [IQR 0.90, 0.97] versus 0.90 [IQR 0.86, 0.95], p<0.001). Median pressure drift was not different between the PW and the PC (0.01 [IQR -0.01, 0.05] versus 0.01 [IQR 0.00, 0.02], p=0.38). Introduction of the PC reduced device success and both hyperemic FFR and resting Pd/Pa compared with the PW alone, leading to re-classifying physiological significance to below ischemic threshold in one out of five assessments.

Intensity-Modulated Radiotherapy of Head and Neck Cancer Aiming to Reduce Dysphagia: Early Dose-Effect Relationships for the Swallowing Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, Felix Y.; Kim, Hyungjin M.; Lyden, Teresa H.

2007-08-01

Purpose: To present initial results of a clinical trial of intensity-modulated radiotherapy (IMRT) aiming to spare the swallowing structures whose dysfunction after chemoradiation is a likely cause of dysphagia and aspiration, without compromising target doses. Methods and Materials: This was a prospective, longitudinal study of 36 patients with Stage III-IV oropharyngeal (31) or nasopharyngeal (5) cancer. Definitive chemo-IMRT spared salivary glands and swallowing structures: pharyngeal constrictors (PC), glottic and supraglottic larynx (GSL), and esophagus. Lateral but not medial retropharyngeal nodes were considered at risk. Dysphagia endpoints included objective swallowing dysfunction (videofluoroscopy), and both patient-reported and observer-rated scores. Correlations between dosesmore » and changes in these endpoints from pre-therapy to 3 months after therapy were assessed. Results: Significant correlations were observed between videofluoroscopy-based aspirations and the mean doses to the PC and GSL, as well as the partial volumes of these structures receiving 50-65 Gy; the highest correlations were associated with doses to the superior PC (p = 0.005). All patients with aspirations received mean PC doses >60 Gy or PC V{sub 65} >50%, and GSL V{sub 50} >50%. Reduced laryngeal elevation and epiglottic inversion were correlated with mean PC and GSL doses (p < 0.01). All 3 patients with strictures had PC V{sub 70} >50%. Worsening patient-reported liquid swallowing was correlated with mean PC (p = 0.05) and esophageal (p 0.02) doses. Only mean PC doses were correlated with worsening patient-reported solid swallowing (p = 0.04) and observer-rated swallowing scores (p = 0.04). Conclusions: These dose-volume-effect relationships provide initial IMRT optimization goals and motivate further efforts to reduce swallowing structures doses to reduce dysphagia and aspiration.« less

The outcome of surgical resection versus assignment to the liver transplant waiting list for hepatocellular carcinoma.

PubMed

Pierie, Jean-Pierre E N; Muzikansky, Alona; Tanabe, Kenneth K; Ott, Mark J

2005-07-01

Optimal management of patients with hepatocellular carcinoma (HCC) is controversial. This study was conducted to evaluate the outcome of tumor resection versus assignment to a liver transplant waiting list (WL) in patients with HCC. Prospectively collected patient data from 1970 to 1997 on 313 patients with HCC were retrospectively analyzed by multivariate analysis to determine the effect of liver disease, method of treatment, and tumor-related factors on survival. A total of 199 patients underwent nonsurgical palliative care (PC), 81 underwent partial liver resection (LR), and 33 were assigned to a liver transplant WL, of which 22 received a donor liver. A total of 91%, 53%, and 91% of the patients had cirrhotic livers in the PC, LR, and WL groups, respectively (P < .001). In the LR group, the absence of a tumor capsule (P < .0001) and a poorly differentiated tumor (P = .027) were both adverse prognostic factors. In the WL group, hepatitis B (P = .02) and American Joint Committee on Cancer tumor stage III (P = .019) were adverse prognostic factors. The 3-year survival rates were 4%, 33%, and 38% for the PC, LR, and WL patients, respectively (P < .0001). The 3-year survival rate in the LR patients was 51% in patients without cirrhosis and 15% in patients with cirrhosis (P < .0001). Patients with locally unresectable tumors, distant disease, or both will continue to receive PC. Patients assigned to liver transplant WLs run the risk of not receiving a donor liver, in which case their survival is predicted to be poor. Survival after resection in a group of patients with advanced tumors is worse than that after transplantation; however, shortages of donor livers presently preclude transplantation in this population of patients.

Influence of Different Factors on Relative Air Humidity in Zaragoza, Spain

NASA Astrophysics Data System (ADS)

Cuadrat, José M.

2015-03-01

In this study, the spatial patterns of relative air humidity and its relation to urban, geographical and meteorological factors in the city of Zaragoza (Spain) is discussed. We created a relative humidity database by means of 32 urban transects. Data were taken on different days and with different weather types. This data set was used to map the mean spatial distribution of urban dry island (UDI). Using stepwise multiple regression analysis and Landsat ETM+ images the relationships between mean UDI and the main geographic-urban factors: topography, land cover and surface reflectivity, have been analyzed. Different spatial patterns of UDI were determined using Principal Component Analysis (Varimax rotation). The three components extracted accounted for 91% of the total variance. PC1 accounted for the most general patterns (similar to mean UDI); PC2 showed a shift of dry areas to the SE and PC3 a shift to NW. Using data on wind direction in Zaragoza, we have found that the displacement of dry areas to the SE (PC 2) was greater during NW winds while the shift to the NW (PC 3) was produced mainly by SE winds.

VizieR Online Data Catalog: Search for extraterrestrial intelligence (Isaacson+, 2017)

NASA Astrophysics Data System (ADS)

Isaacson, H.; Siemion, A. P. V.; Marcy, G. W.; Lebofsky, M.; Price, D. C.; MacMahon, D.; Croft, S.; Deboer, D.; Hickish, J.; Werthimer, D.; Sheikh, S.; Hellbourg, G.; Enriquez, J. E.

2017-08-01

The stellar sample is defined by two selection criteria. The first is a volume-limited sample of stars within 5pc of the Sun. The second is a spectral class complete sample consisting of stars across the main sequence and some giant branch stars, all within 50pc. We combined the two sub-samples (5pc and 5-50pc) to produce the final set of 1709 target stars that are listed in Table 1. (1 data file).

Phototoxic effect of aluminium-chlorine and aluminium-hydroxide phthalocyanines on Leishmania (l.) amazonensis.

PubMed

Nesi-Reis, V; Navasconi, T R; Lera-Nosone, D S S L; Oliveira, E L; Barbosa, P M; Caetano, W; Silveira, T G V; Aristides, S M A; Hioka, N; Lonardoni, M V C

2018-03-01

This study investigated the activity of photosensitive phthalocyanines on promastigotes and amastigotes of Leishmania (L.) amazonensis. Aluminum phthalocyanine chloride (AlPcCl), Aluminum phthalocyanine hydroxide (AlPcOH) and zinc phthalocyanine (PcZn) were tested in the presence (matte red LED, potency of 2.5-2.3 μW for 30 min) and absence of light against L. amazonensis promastigotes and the parasite viability was evaluated after 24, 48 and 72 h. The amastigote forms were treated with AlPcCl and AlPcOH, following the same lighting protocols described for the promastigote forms, being evaluated after 24 h. Cytotoxicity to human erythrocytes and peritoneal macrophages was also evaluated. The results showed that AlPcCl and AlPcOH in the presence of light have antileishmania activity, with leishmanistatic effects on promastigotes and amastigotes of L. amazonensis, without causing cytotoxicity to peritoneal macrophages and erythrocytes. The concentrations that inhibited 50% of the promastigote forms after 24 h of light exposure were 0.21 ± 0.08 μM for AlPcCl and 0.23 ± 0.06 μM for AlPcOH. In 48 h and 72 h after the treatment, the IC 50 of AlPcCl was 0.13 ± 0.02 and 0.12 ± 0.03 μM and for AlPcOH was 0.14 ± 0.01 μM and 0.11 ± 0.01 μM, respectively. PcZn showed no activity on promastigotes of L. amazonensis. This study showed a substantial photodynamic activity of the phthalocyanines AlPcCl and AlPcOH against intracellular amastigotes forms of L. amazonensis after irradiation, presenting IC 50 values of 0.62 ± 0.06 μM and 0.92 ± 0.12 μM, respectively. These results support the possibility of using photodynamic therapy for the treatment of cutaneous leishmaniasis. Copyright © 2017 Elsevier B.V. All rights reserved.

Solutions for Digital Video Transmission Technology Final Report CRADA No. TC02068.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, A. T.; Rivers, W.

This Project aimed at development of software for seismic data processing based on the Geotool code developed by the American company Multimax., Inc. The Geotool code was written in early 90-es for the UNIX platform. Under Project# 2821, functions of the old Geotool code were transferred into a commercial version for the Microsoft XP and Vista platform with addition of new capabilities on visualization and data processing. The developed new version of the Geotool+ was implemented using the up-to-date tool Microsoft Visual Studio 2005 and uses capabilities of the .NET platform. C++ was selected as the main programming language formore » the Geotool+. The two-year Project was extended by six months and funding levels increased from 600,000 to $670,000. All tasks were successfully completed and all deliverables were met for the project even though both the industrial partner and LLNL principal investigator left the project before its final report.« less

Association between late-onset hypogonadism syndrome plus metabolic syndrome and prostate cancer and its aggressiveness.

PubMed

Fuentes-Pastor, J; Pellejero, P; Ortiz, I; Ramírez-Backhaus, M; de Gracia, A; Marrugo, C; Gomez-Ferrer, A; Calatrava, A; Rubio-Briones, J; Rodriguez-Torreblanca, C; Solsona-Narbón, E

2016-09-01

To assess the relationship between prostate cancer (PC) and the presence of metabolic syndrome and late-onset hypogonadism (LOH) syndrome. A retrospective study was conducted on 686 patients who underwent prostate biopsy. We analysed the demographic variables, clinical data and biopsy results. To diagnose metabolic syndrome, we employed the criteria of the American Heart Association. For the diagnosis of LOH syndrome, we employed the Androgen Deficiency in the Aging Male questionnaire and testosterone levels (TT). We evaluated the relationship between free testosterone (FT) and bioavailable testosterone (BT) on one hand and PC and its aggressiveness on the other, as well as the usefulness of the TT to prostate specific antigen (TT/PSA) ratio in the PC diagnosis. The patient's median age was 65 years. Metabolic syndrome is not associated with PC (39.4% vs. 35%; P=.1) but is associated with a PC Gleason score >7 (50.4% vs. 29.44%; P=.002). LOH, low FT and low BT are associated with an increased presence of PC (51% vs. 35%, P=.02; 44.86% vs. 33.33%, P=.03; and 46.46% vs. 33.08%, P=.01, respectively) and with an increased probability of a PC Gleason score >7 (61.54% vs. 37.5%, P=.02; 54.17% vs. 34.12%, P=.02; 54.35% vs. 34.48%, P=.02, respectively). Additionally, the median TT/PSA ratio was significantly lower in patients with positive biopsies (P=.022). Metabolic syndrome was not associated with the probability of having PC but was associated with a PC Gleason score >7. Moreover, LOH syndrome had a higher percentage of PC and a greater presence of PC Gleason scores >7, as did low levels of FT and low levels of BT. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

A proteomic approach to the analysis of the components of the phycobilisomes from two cyanobacteria with complementary chromatic adaptation: Fremyella diplosiphon UTEX B590 and Tolypothrix PCC 7601.

PubMed

Pérez-Gómez, Bertha; Mendoza-Hernández, Guillermo; Cabellos-Avelar, Tecilli; Leyva-Castillo, Lourdes Elizabeth; Gutiérrez-Cirlos, Emma Berta; Gómez-Lojero, Carlos

2012-10-01

Tolypothrix PCC 7601 and Fremyella diplosiphon UTEX B590 can produce two alternative phycobilisome (PBS) rods. PE-PBSs with one phycocyanin (PC) disk and multiple phycoerythrin (PE) disks are found in cells grown under green light (GL). PC-PBSs with only PC disks are obtained from cells grown under red light (RL). In this manuscript, we show the localization of the linker proteins and ferredoxin-NADP(+) oxidoreductase (FNR) in the PC-PBS and of PE-PBS rods using visible spectroscopy and mass spectrometry. PE-PBSs with different [PE]/[PC] ratios and PC-PBSs with different [PC]/[AP] (AP, allophycocyanin) ratios were isolated. CpeC was the primary rod linker protein found in the PBSs with a [PE]/[PC] ratio of 1.1, which indicates that this is the rod linker at the interphase PC-PE. CpeC and CpeD were identified in the PBSs with a [PE]/[PC] ratio of 1.6, which indicates that CpcD is the linker between the first and the second PE hexamers. Finally, CpeC, CpeD, and CpeE were found in the PBSs with a [PE]/[PC] ratio of 2.9, indicating the position of CpeE between the second and third PE moieties. CpcI2 was identified in the two PC-PBSs obtained from cells grown under RL, which indicates that CpcI2 is the linker between the first and second PC hexamers. CpcH2 was identified only in the PC-PBSs from Tolypothrix with a high [PC]/[AP] ratio of 1.92, which indicates that CpcH2 is the linker between the second and third PC hexamers. The PC-PBSs contained the rod cap protein L(R)(10) (CpcD), but this protein was absent in the PE-PBSs. PE-PBSs (lacking L(R)(10)) incorporated exogenous rFNR in a stoichiometry of up to five FNRs per PBS. A maximum of two FNRs per PBS were found in PC-PBSs (with L(R)(10)). These observations support the hypothesis that FNR binds at the distal ends of the PBS rods in the vacant site of CpcD L(R)(10). Finally, the molecular mass of the core membrane linker (L(CM)) was determined to be 102 kDa from a mass spectrometry analysis.

Preliminary experience on the use of the Adnatest® system for detection of circulating tumor cells in prostate cancer patients.

PubMed

Todenhöfer, Tilman; Hennenlotter, Jörg; Feyerabend, Susan; Aufderklamm, Stefan; Mischinger, Johannes; Kühs, Ursula; Gerber, Valentina; Fetisch, Jasmin; Schilling, David; Hauch, Siegfried; Stenzl, Arnulf; Schwentner, Christian

2012-08-01

The Adnatest® system combines immunomagnetic enrichment of epithelial cells with polymerase chain reaction for prostate cancer (PC)-specific transcripts for the detection circulating tumor cells (CTCs). We evaluated the Adnatest® in patients with castration-resistant PC receiving docetaxel chemotherapy. CTCs were assessed in 16 patients with castration-resistant PC before cycles one and three of chemotherapy. Furthermore, markers of stem cells and epithelial-mesenchymal transition were assessed. Treatment response was assessed by imaging and prostate-specific antigen measurements. Before chemotherapy, 11 patients were Adnatest®-positive whereas five patients were Adnatest®-positive before cycle three. A positive Adnatest® correlated with radiological progression (p=0.02). Rates of disease progression in epidermal growth factor receptor (EGFR)-positive and -negative patients were 100% and 7.7% (p=0.03). In this preliminary study, the Adnatest® detected CTCs in a considerable proportion of patients with castration-resistant PC. First data on certain markers (EGFR and aldehyd dehydrogenase 1) encourage future studies investigating transcripts predicting treatment response.

An innovative method for the solidification/stabilization of PAHs-contaminated soil using sulfonated oil.

PubMed

Ma, Fujun; Wu, Bin; Zhang, Qian; Cui, Deshan; Liu, Qingbing; Peng, Changsheng; Li, Fasheng; Gu, Qingbao

2018-02-15

Stabilization/solidification (S/S) has been successfully employed in many superfund sites contaminated with organic materials. However, this method's long-term effectiveness has not been fully evaluated and the increase in soil volume following treatment is unfavorable to follow-up disposal. The present study developed a novel method for the S/S of PAHs-contaminated soil with the facilitation of sulfonated oil (SO). Adding SO significantly improved the unconfined compressive strength (UCS) values of Portland cement and activated carbon (PC-AC) treated soil samples, and the UCS values of the soil sample treated with 0.02% of SO were up to 2.3 times higher than without SO addition. When the soil was treated with PC-AC-SO, the PAHs leaching concentrations were 14%-25% of that in leachates of the control soil, and high molecular weight PAHs including benzo(a)pyrene were rarely leached. Freeze/thaw durability tests reveal that the leachability of PAHs was not influenced by freeze-thaw cycles. The UCS values of PC-AC-SO treated soil samples were 2.2-3.4 times greater than those of PC-AC treated soil samples after 12 freeze-thaw cycles. The PC-AC-SO treated soils resist disintegration better when compared to the PC-AC treated soils. The SEM micrographs reveal that the soils' compactness was significantly improved when treated with SO. Copyright © 2017 Elsevier B.V. All rights reserved.

Predictors of CPAP compliance in different clinical settings: primary care versus sleep unit.

PubMed

Nadal, Núria; de Batlle, Jordi; Barbé, Ferran; Marsal, Josep Ramon; Sánchez-de-la-Torre, Alicia; Tarraubella, Nuria; Lavega, Merce; Sánchez-de-la-Torre, Manuel

2018-03-01

Good adherence to continuous positive airway pressure (CPAP) treatment improves the patient's quality of life and decreases the risk of cardiovascular disease. Previous studies that have analyzed the adherence to CPAP were performed in a sleep unit (SU) setting. The involvement of primary care (PC) in the management of obstructive sleep apnea (OSA) patients receiving CPAP treatment could introduce factors related to the adherence to treatment. The objective was to compare the baseline predictors of CPAP compliance in SU and PC settings. OSA patients treated with CPAP were followed for 6 months in SU or PC setting. We included baseline clinical and anthropometrical variables, the Epworth Sleep Scale (ESS) score, the quality of life index, and the Charlson index. A logistic regression was performed for each group to determine the CPAP compliance predictors. Discrimination and calibration were performed using the area under the curve and Hosmer-Lemeshow tests. We included 191 patients: 91 in the PC group and 100 in the SU group. In 74.9% of the patients, the compliance was ≥ 4 h per day, with 80% compliance in the SU setting and 69.2% compliance in the PC setting (p = 0.087). The predictors of CPAP compliance were different between SU and PC settings. Body mass index, ESS, and CPAP pressure were predictors in the SU setting, and ESS, gender, and waist circumference were predictors in the PC setting. The predictors of adequate CPAP compliance vary between SU and PC settings. Detecting compliance predictors could help in the planning of early interventions to improve CPAP adherence.

Temozolomide treatment of pituitary carcinomas and atypical adenomas: systematic review of case reports

PubMed Central

Ji, Yan; Vogel, Rachel Isaksson; Lou, Emil

2016-01-01

Background Pituitary carcinomas (PC) and atypical pituitary adenomas (APA) are rare variants of pituitary tumors for which no evidence-based treatment currently exists. We sought to determine whether temozolomide represents an effective chemotherapeutic option for patients with PC and APA. Methods A systematic review was performed using all published cases of PC and APA treated with temozolomide, and for which information on treatment regimen, clinical response, and survival could be identified. The primary goal of this analysis was to describe overall survival and progression-free survival among PC and APA patients after temozolomide treatment. Secondary goals included assessment of response rate and biomarkers of response. Results We identified 57 cases and obtained follow-up data on 54 patients (31 APA and 23 PC) for analysis. Estimates of 5-year progression-free survival and overall survival were 21.9% and 57.4% for patients with APA and 36.1% and 56.2% for patients with PC. Among those who responded to temozolomide, overall survival was marginally statistically significantly greater for patients on long-term temozolomide therapy compared with those who were not (5-year overall survival 91.7% vs 54.1%, P = .08); Progression-free survival results were similar but not statistically significant. The objective response rate was 48.4% for patients with APA and 65.2% for patients with PC. Stable disease occurred in 29% of APA and 17.4% of PC patients. Neither histology nor expression of Ki-67 correlated with response; however, negative O6-methylguanine-DNA methyltransferase staining was strongly related to response to temozolomide in patients with APA (P < .001). Conclusions Temozolomide is an effective treatment of both PC and APA, and long-term treatment can be considered for particularly aggressive cases. PMID:27551432

Mangiferin inhibition of proliferation and induction of apoptosis in human prostate cancer cells is correlated with downregulation of B-cell lymphoma-2 and upregulation of microRNA-182.

PubMed

Li, Minglin; Ma, Huili; Yang, Lixin; Li, Peng

2016-01-01

Mangiferin, a flavonoid extracted from the mango tree, possesses anti-inflammatory, antibacterial, anti-herpes simplex and antitumor activity, and is able to affect immune function. The present study investigated the anticancer effects of mangiferin treatment on PC3 human prostate cancer cells, and the potential underlying mechanisms. In the present study, an MTT assay was used to analyze the proliferation of PC3 cells. Subsequently, flow cytometry and colorimetric assay kits were utilized to measure the PC3 cell apoptotic rate. The expression levels of B-cell lymphoma-2 (Bcl-2) and microRNA-182 (miR-182) were detected using western blot analysis and quantitative reverse transcription-polymerase chain reaction, respectively. Finally, miR-182 and anti-miR-182 were transfected into PC3 cells, which were used to investigate the effects of mangiferin. Mangiferin treatment reduced the proliferation of PC3 human prostate cancer cells in a concentration- and time-dependent manner. In addition, mangiferin was able to promote apoptosis and induce the caspase-3 activity of PC3 human prostate cancer cells. Mangiferin treatment was also able to significantly reduce Bcl-2 expression levels and enhance miR-182 expression in PC3 cells. Finally, it was observed that mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells, and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182.

An HPLC-ICP-MS technique for determination of cadmium-phytochelatins in genetically modified Arabidopsis thaliana.

PubMed

Sadi, Baki B M; Vonderheide, Anne P; Gong, Ji-Ming; Schroeder, Julian I; Shann, Jodi R; Caruso, Joseph A

2008-01-01

A reversed-phase high-performance liquid chromatographic technique was developed to separate cadmium-phytochelatin complexes (Cd-PC2, Cd-PC3, and Cd-PC4) of interest in the plant Arapidopsis thaliana. High-performance liquid chromatography (HPLC) was coupled to an inductively coupled plasma mass spectrometric (ICP-MS) system with some modification to the interface. This was done in order to sustain the plasma with optimum sensitivity for cadmium detection in the presence of the high methanol loads used in the gradient elution of the reversed-phase separation. The detection limits were found to be 91.8 ngl(-1), 77.2 ngl(-1) and 49.2 ngl(-1) for Cd-PC2, Cd-PC3, and Cd-PC4 respectively. The regression coefficients (r2) for Cd-PC2 to Cd-PC4 detection ranged from 0.998 to 0.999. The method was then used to investigate the occurrence and effect of cadmium-phytochelatin complexes in wild-type Arabidopsis and a phytochelatin-deficient mutant cad1-3 that had been genetically modified to ectopically express the wheat TaPCS1 phytochelatin synthase enzyme. The primary complex found in both wild-type and transgenic plants was Cd-PC2. In both lines, higher levels of Cd-PC2 were found in shoots than in roots, showing that phytochelatin synthases contribute to the accumulation of cadmium in shoots, in the Cd-PC2 form. Genetic modification did, however, impact the overall accumulation of Cd. Transgenic plants contained almost two times more cadmium in the form of Cd-PC2 in their roots than did the corresponding wild-type plants. Similarly, the shoot samples of the modified species also contained more (by 1.6 times) cadmium in the form of Cd-PC2 than the wild type. The enhanced role of PC2 in the transgenic Arabidopsis correlates with data showing long-distance transport of Cd in transgenic plants. Targeted transgenic expression of non-native phytochelatin synthases may contribute to improving the efficiency of plants for phytoremediation.

A pH-sensitive micelle composed of heparin, phospholipids, and histidine as the carrier of photosensitizers: Application to enhance photodynamic therapy of cancer.

PubMed

Debele, Tilahun Ayane; Mekuria, Shewaye Lakew; Tsai, Hsieh-Chih

2017-05-01

In this study, we describe the synthesis of a stable, pH-sensitive micelle composed of heparin, 1, 2-distearoyl-sn-glycerol-3-phosphoethanolamine, and l-histidine (HDH) through 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) chemistry. 1 H-Nuclear magnetic resonance (NMR) and Fourier transform infrared spectroscopy (FTIR) analyses confirmed the formation of HDH copolymers and dynamic light scattering (DLS) measurements indicated a particle size of 111.57±12.36nm and zeta potential of -59.8±5.2mV for the nanoparticles. The drug-loading and encapsulation efficiency of the micelles were 14.52±1.2% and 65.47±1.87%, respectively. Drug release studies showed approximately 91% zinc phthalocyanine (ZnPc) release from micelles in acidic conditions (pH 5.0) in comparison with 63% in physiological conditions (pH 7.4) after 96h of incubation. Singlet oxygen ( 1 O 2 ) detection revealed that the micelles prevented ZnPc aggregation and enhanced 1 O 2 generation. Cellular uptake of ZnPc-loaded micelles (ZnPc-HDH) was observed using confocal microscopy. Phototoxicity experiments in HeLa cells showed that ZnPc-loaded micelles had higher toxicity than that shown by the same concentration of free ZnPc. Hence, pH-sensitive HDH micelles are a promising carrier for hydrophobic ZnPc and improving PDT efficacy. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluation of quality of life using a tablet PC-based survey in cancer patients treated with radiotherapy: a multi-institutional prospective randomized crossover comparison of paper and tablet PC-based questionnaires (KROG 12-01).

PubMed

Kim, Haeyoung; Park, Hee Chul; Yoon, Sang Min; Kim, Tae Hyun; Kim, Jinsung; Kang, Min Kyu; Jung, Jinhong; Kim, Sang-Won; Yea, Ji Woon; Park, Sung Ho; Park, Young Suk

2016-10-01

This study compared a tablet PC questionnaire with a paper method for reliability and patient preferences in the acquisition of patient-reported outcomes (PROs) for patients treated with radiotherapy. By comparing the two modes of PRO administration, we aimed to evaluate the adequacy of using tablet PC questionnaires in future clinical use. Patients were randomized in a crossover study design using two different methods for PRO entry. A group of 89 patients answered a paper questionnaire followed by the tablet PC version, whereas 89 patients in another group completed the tablet PC questionnaire followed by the paper version. Surveys were performed four times per patient throughout the course of the radiotherapy. The Korean versions of the M.D. Anderson Symptom Inventory (MDASI-K) and the Brief Fatigue Inventory (BFI-K) were used. The primary endpoint of our current study was an assessment of patient preference for the survey method. The proportions of patients preferring each mode of questionnaire were evaluated. The proportion of patients who preferred the tablet PC version, paper form, or who had no preference was 52.2, 22.1, and 25.7 %, respectively. More than half of the patients preferred the tablet PC to the paper version in all four surveys. Age, gender, educational status, prior experience of using a tablet PC, and the order of paper to tablet PC administration did not impact patient preferences. Inter-class correlation coefficients (ICCs) between the modes were 0.92 for MDASI-K and 0.94 for BFI-K and ranged from 0.91 to 0.96 on both instruments during the four surveys. A tablet PC-based PRO is an acceptable and reliable method compared with paper-based data collection for Korean patients receiving radiotherapy.

Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat

PubMed Central

Reeds, Dominic N.; Mohammed, B. Selma; Klein, Samuel; Boswell, Craig Brian

2013-01-01

Background: Phosphatidylcholine and deoxycholate (PC-DC) injections are a popular nonsurgical method to eliminate unwanted fat. The safety and efficacy of this approach is uncertain. Objective: The authors evaluate the effects of PC-DC treatments on body composition, adipocyte function, and mechanisms responsible for fat loss. Methods: This randomized, open-label study enrolled 13 women with a body mass index (BMI) ≤30 kg/m2 and lower abdominal subcutaneous fat suitable for small-volume liposuction. Patients were randomized by the final digit of their Social Security numbers and received between 2 and 4 PC-DC treatments, spaced 8 weeks apart. One side below the umbilicus was injected with PC-DC. The contralateral, control side received no treatment. Adipose tissue biopsies were performed on the treated side at baseline, 1 week after the first treatment, and 8 weeks after the final treatment. The primary outcome was change in adipose tissue thickness at baseline and 8 weeks after the final treatment. Results: Seven women completed the study. Treatment with PC-DC significantly reduced the thickness of the anterior subcutaneous abdominal fat (P = .004). Adipose tissue showed rapid increases in crown-like structures, macrophage infiltration, and reduced expression of leptin, hormone-sensitive lipase, adipose tissue triglyceride lipase, and CD36. Plasma C-reactive protein, lipid profile, and plasma glucose concentrations were unchanged. Conclusions: PC-DC injections can effectively reduce abdominal fat volume and thickness by inducing adipocyte necrosis. These treatments do not appear to increase circulating markers of inflammation or affect glucose and lipid metabolism. Level of Evidence: 3 PMID:23439063

Factors associated with successful transition among children with disabilities in eight European countries

PubMed Central

2017-01-01

Introduction This research paper aims to assess factors reported by parents associated with the successful transition of children with complex additional support requirements that have undergone a transition between school environments from 8 European Union member states. Methods Quantitative data were collected from 306 parents within education systems from 8 EU member states (Bulgaria, Cyprus, Greece, Ireland, the Netherlands, Romania, Spain and the UK). The data were derived from an online questionnaire and consisted of 41 questions. Information was collected on: parental involvement in their child’s transition, child involvement in transition, child autonomy, school ethos, professionals’ involvement in transition and integrated working, such as, joint assessment, cooperation and coordination between agencies. Survey questions that were designed on a Likert-scale were included in the Principal Components Analysis (PCA), additional survey questions, along with the results from the PCA, were used to build a logistic regression model. Results Four principal components were identified accounting for 48.86% of the variability in the data. Principal component 1 (PC1), ‘child inclusive ethos,’ contains 16.17% of the variation. Principal component 2 (PC2), which represents child autonomy and involvement, is responsible for 8.52% of the total variation. Principal component 3 (PC3) contains questions relating to parental involvement and contributed to 12.26% of the overall variation. Principal component 4 (PC4), which involves transition planning and coordination, contributed to 11.91% of the overall variation. Finally, the principal components were included in a logistic regression to evaluate the relationship between inclusion and a successful transition, as well as whether other factors that may have influenced transition. All four principal components were significantly associated with a successful transition, with PC1 being having the most effect (OR: 4.04, CI: 2.43–7.18, p<0.0001). Discussion To support a child with complex additional support requirements through transition from special school to mainstream, governments and professionals need to ensure children with additional support requirements and their parents are at the centre of all decisions that affect them. It is important that professionals recognise the educational, psychological, social and cultural contexts of a child with additional support requirements and their families which will provide a holistic approach and remove barriers for learning. PMID:28636649

Factors associated with successful transition among children with disabilities in eight European countries.

PubMed

Ravenscroft, John; Wazny, Kerri; Davis, John M

2017-01-01

This research paper aims to assess factors reported by parents associated with the successful transition of children with complex additional support requirements that have undergone a transition between school environments from 8 European Union member states. Quantitative data were collected from 306 parents within education systems from 8 EU member states (Bulgaria, Cyprus, Greece, Ireland, the Netherlands, Romania, Spain and the UK). The data were derived from an online questionnaire and consisted of 41 questions. Information was collected on: parental involvement in their child's transition, child involvement in transition, child autonomy, school ethos, professionals' involvement in transition and integrated working, such as, joint assessment, cooperation and coordination between agencies. Survey questions that were designed on a Likert-scale were included in the Principal Components Analysis (PCA), additional survey questions, along with the results from the PCA, were used to build a logistic regression model. Four principal components were identified accounting for 48.86% of the variability in the data. Principal component 1 (PC1), 'child inclusive ethos,' contains 16.17% of the variation. Principal component 2 (PC2), which represents child autonomy and involvement, is responsible for 8.52% of the total variation. Principal component 3 (PC3) contains questions relating to parental involvement and contributed to 12.26% of the overall variation. Principal component 4 (PC4), which involves transition planning and coordination, contributed to 11.91% of the overall variation. Finally, the principal components were included in a logistic regression to evaluate the relationship between inclusion and a successful transition, as well as whether other factors that may have influenced transition. All four principal components were significantly associated with a successful transition, with PC1 being having the most effect (OR: 4.04, CI: 2.43-7.18, p<0.0001). To support a child with complex additional support requirements through transition from special school to mainstream, governments and professionals need to ensure children with additional support requirements and their parents are at the centre of all decisions that affect them. It is important that professionals recognise the educational, psychological, social and cultural contexts of a child with additional support requirements and their families which will provide a holistic approach and remove barriers for learning.

Evaluation of Aerogel Clad Optical Fibers Final Report CRADA No. TSB-1448-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maitland, Duncan; Droege, M. W.

Fiber-optic based sensors will be needed for in situ monitoring of degradation products in various components of nuclear weapons. These sensors typically consist of a transducer located at the measurement site whose optical properties are modulated by interaction with the targeted degradation product. The interrogating light source and the detector for determining sensor response are located remotely. These two subsystems are connected by fiber optic cables. LLNL has developed a new technology, aerogel clad optical fibers, that have the advantage of accepting incident rays over a much wider angular range than normal glass clad fibers. These fibers are also capablemore » of transmitting light more efficiently. These advantages can lead to a factor of 2-4 improvement in sensitivity and detection limit.« less

Improved Fiber Optics Final Report CRADA No. TSB-957-94

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fox, Glenn; Wilford, Sandy

The existing chemistry of Lumenyte® (an illumination fiber optic developed by LIC) was such that the component monomers inherently polymerized to a very hard mass if exposed to environmental IR, UV, or a combination of these frequencies. Lumenyte optic also would cure to a hard mass by exposure to the UV & IR generated by the illuminating lamps-although this could occur at a much slower rate, and the hardening could occur even when the adverse frequencies were filtered. The resultant product did not have the flexibility for the required applications. LIC's objective was to include other monomeric components in themore » formulation to impart permanent flexibility. LIC sought the expertise and the use of the facilities in the Polymeric Materials Section at LLNL to achieve this objective.« less

Ceramic High Efficiency Particulate Air (HEPA) Filter Final Report CRADA No. TC02102.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitchell, M.; Morse, T.

This was a collaborative effort between Lawrence Livermore National Security, LLC (formerly The Regents of the University of California)/Lawrence Livermor e National Laboratory (LLNL) and Flanders-Precisionaire (Flanders), to develop ceramic HEP A filters under a Thrust II Initiative for Proliferation Prevention (IPP) project. The research was conducted via the IPP Program at Commonwe alth of Independent States (CIS) Institutes, which are handled under a separate agreement. The institutes (collectively referred to as "CIS Institutes") involved with this project were: Bochvar: Federal State Unitarian Enterprise All-Russia Scientific and Research Institute of Inorganic Materials (FSUE VNIINM); Radium Khlopin: Federal State Unitarian Enterprisemore » NPO Radium Institute named (FSUE NPO Radium Institute); and Bakor: Science and Technology Center Bakor (STC Bakor).« less

Water Treatment Using Advanced Ultraviolet Light Sources Final Report CRADA No. TC02089.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoppes, W.; Oster, S.

This was a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Teknichal Services, LLC (TkS), to develop water treatment systems using advanced ultraviolet light sources. The Russian institutes involved with this project were The High Current Electronics Institute (HCEI) and Russian Institute of Technical Physics-Institute of Experimental Physics (VNIIEF). HCEI and VNIIEF developed and demonstrated the potential commercial viability of short-wavelength ultraviolet excimer lamps under a Thrust 1 Initiatives for Proliferation Prevention (IPP) Program. The goals of this collaboration were to demonstrate both the commercial viability of excilampbased watermore » disinfection and achieve further substantial operational improvement in the lamps themselves; particularly in the area of energy efficiency.« less

Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE)

PubMed Central

Han, Thang S; Krone, Nils; Willis, Debbie S; Conway, Gerard S; Hahner, Stefanie; Rees, D Aled; Stimson, Roland H; Walker, Brian R; Arlt, Wiebke; Ross, Richard J

2013-01-01

Context Quality of life (QoL) has been variously reported as normal or impaired in adults with congenital adrenal hyperplasia (CAH). To explore the reasons for this discrepancy we investigated the relationship between QoL, glucocorticoid treatment and other health outcomes in CAH adults. Methods Cross-sectional analysis of 151 adults with 21-hydroxylase deficiency aged 18–69 years in whom QoL (assessed using the Short Form Health Survey), glucocorticoid regimen, anthropometric and metabolic measures were recorded. Relationships were examined between QoL, type of glucocorticoid (hydrocortisone, prednisolone and dexamethasone) and dose of glucocorticoid expressed as prednisolone dose equivalent (PreDEq). QoL was expressed as z-scores calculated from matched controls (14 430 subjects from UK population). Principal components analysis (PCA) was undertaken to identify clusters of associated clinical and biochemical features and the principal component (PC) scores used in regression analysis as predictor of QoL. Results QoL scores were associated with type of glucocorticoid treatment for vitality (P=0.002) and mental health (P=0.011), with higher z-scores indicating better QoL in patients on hydrocortisone monotherapy (P<0.05). QoL did not relate to PreDEq or mutation severity. PCA identified three PCs (PC1, disease control; PC2, adiposity and insulin resistance and PC3, blood pressure and mutations) that explained 61% of the variance in observed variables. Stepwise multiple regression analysis demonstrated that PC2, reflecting adiposity and insulin resistance (waist circumference, serum triglycerides, homeostasis model assessment of insulin resistance and HDL-cholesterol), related to QoL scores, specifically impaired physical functioning, bodily pain, general health, Physical Component Summary Score (P<0.001) and vitality (P=0.002). Conclusions Increased adiposity, insulin resistance and use of prednisolone or dexamethasone are associated with impaired QoL in adults with CAH. Intervention trials are required to establish whether choice of glucocorticoid treatment and/or weight loss can improve QoL in CAH adults. PMID:23520247

How to define pathologic pelvic floor descent in MR defecography during defecation?

PubMed

Schawkat, Khoschy; Heinrich, Henriette; Parker, Helen L; Barth, Borna K; Mathew, Rishi P; Weishaupt, Dominik; Fox, Mark; Reiner, Caecilia S

2018-06-01

To assess the extents of pelvic floor descent both during the maximal straining phase and the defecation phase in healthy volunteers and in patients with pelvic floor disorders, studied with MR defecography (MRD), and to define specific threshold values for pelvic floor descent during the defecation phase. Twenty-two patients (mean age 51 ± 19.4) with obstructed defecation and 20 healthy volunteers (mean age 33.4 ± 11.5) underwent 3.0T MRD in supine position using midsagittal T2-weighted images. Two radiologists performed measurements in reference to PCL-lines in straining and during defecation. In order to identify cutoff values of pelvic floor measurements for diagnosis of pathologic pelvic floor descent [anterior, middle, and posterior compartments (AC, MC, PC)], receiver-operating characteristic (ROC) curves were plotted. Pelvic floor descent of all three compartments was significantly larger during defecation than at straining in patients and healthy volunteers (p < 0.002). When grading pelvic floor descent in the straining phase, only two healthy volunteers showed moderate PC descent (10%), which is considered pathologic. However, when applying the grading system during defecation, PC descent was overestimated with 50% of the healthy volunteers (10 of 20) showing moderate PC descent. The AUC for PC measurements during defecation was 0.77 (p = 0.003) and suggests a cutoff value of 45 mm below the PCL to identify patients with pathologic PC descent. With the adapted cutoff, only 15% of healthy volunteers show pathologic PC descent during defecation. MRD measurements during straining and defecation can be used to differentiate patients with pelvic floor dysfunction from healthy volunteers. However, different cutoff values should be used during straining and during defecation to define normal or pathologic PC descent.

Random spot urine protein to creatinine ratio is a reliable measure of proteinuria in lupus nephritis in Koreans.

PubMed

Choi, In Ah; Park, Jin Kyun; Lee, Eun Young; Song, Yeong Wook; Lee, Eun Bong

2013-01-01

The accurate assessment of proteinuria is critical for the management of lupus nephritis. Measuring the protein to creatinine (P/C) ratio in random spot urine (RSU) samples has been introduced as an alternative to the 24-hour (24h) urine collection method. However, it remains unclear as to whether the RSU P/C ratio is reliable for assessing lupus nephritis (LN) in routine clinical practice. In total, 275 pairs of 24h urine and RSU samples from 102 patients with biopsy-proven LN were analysed. The correlation and concordance between the P/C ratios in the two sample types were assessed by Pearson or Spearman correlation and intra-class correlation coefficient (ICC) using mixed models for repeated measurements, respectively. The mean 24h urine P/C ratio was 3.2 ± 4.9. Overall, RSU P/C ratio correlated strongly with the 24h urine P/C ratio (r=0.944, p<0.001) with an excellent agreement (ICC=0.949, 95% confidence interval [CI]: 0.69-1.00). Subgroup analyses revealed that the correlation remained high in class II, III, IV, and V LN (rho=0.868, p<0.001; rho=0.649, p=0.007; r=0.945, p<0.001; and rho=0.900, p=0.001, respectively). The correlation between the 24h urine and RSU P/C ratio in the range of 0.5 to 3 was good (r=0.720, p<0.001) with ICC of 0.659 (95%CI 0.554-0.812). RSU P/C ratio ≥0.5 could predict 24h PCR ≥0.5 with 91.7% sensitivity and 70.2% specificity, whereas RSU P/C ratio ≥1.0 increased specificity up to 94.7%. The RSU P/C ratio is an excellent alternative to the 24 hour P/C ratio for assessing the presence of clinically significant proteinuria in LN. RSU P/C ratio >1.0 may prompt directly to a renal biopsy, whereas RSU P/C ratio between 0.5-1.0 should be followed by a confirmatory 24h urine collection.

A Formal Palliative Care Service Improves the Quality of Care in Patients with Stage IV Cancer and Bowel Obstruction.

PubMed

Gabriel, Emmanuel; Kukar, Moshim; Groman, Adrienne; Alvarez-Perez, Amy; Schneider, Jaclyn; Francescutti, Valerie

2017-02-01

Patients with stage IV cancer and bowel obstruction present a complicated management problem. The aim of this study was to evaluate the role of the palliative care service (PC) in the management of this complex disease process. A retrospective analysis was conducted of all patients admitted to Roswell Park Cancer Institute with stage IV cancer and bowel obstruction from 2009 to 2012 after the institution of a formal PC. This cohort was matched to similar patients from 2005 to 2008 (no palliative care service or NPC). Patient characteristics and outcomes included baseline demographics, comorbid conditions, do-not-resuscitate (DNR) status, laboratory parameters, medical and surgical management, length of stay, symptom relief, and disposition status. A total of 19 patients were identified in the PC group. Based on the PC group baseline characteristics, 19 patients were identified for the NPC group using matched values. Regarding outcomes, there were significant differences in the medication regimens (narcotics, octreotide, and Decadron) between the 2 groups. In the PC group, 14 of 19 patients showed improvement compared to 9 of 19 in the NPC group. Nearly 60% of patients in the PC group had a formal DNR order versus 10.5% in NPC ( P = .002). A significantly higher percentage of patients were discharged to hospice in the PC group (47.4% vs 0.0%, P = .006). Palliative care consultation improves the quality of care for patients with stage IV cancer and bowel obstruction, with particular benefits in symptom management, end-of-life discussion, and disposition to hospice.

Adapting PC104Plus for Space

NASA Technical Reports Server (NTRS)

Abbott, Larry; Cox, Gary; Nguyen, Hai

2000-01-01

This article addresses the issues associated with adapting the commercial PC104Plus standard and its associated architecture to the requirements of space applications. In general, space applications exhibit extreme constraints on power, weight, and volume. EMI and EMC are also issues of significant concern. Additionally, space applications have to survive high radiation environment. Finally, NASA is always concerned about achieving cost effective solutions that are compatible with safety and launch constraints. Weight and volume constraints are directly related to high launch cost. Power on the other hand is not only related to the high launch costs, but are related to the problem of dissipating the resulting heat once in space. The article addresses why PC104Plus is an appropriate solution for the weight and volume issues. The article also addresses what NASA did electrically to reduce power consumption and mechanically dissipate the associated heat in a microgravity and vacuum environment, and how these solutions allow NASA to integrate various sizes of ruggedized custom PC104 boards with COTS, PC104 complaint boards for space applications. In addition to the mechanical changes to deal with thermal dissipation NASA also made changes to minimize EMI. Finally, radiation issues are addressed as well as the architectural and testing solutions and the implications for use of COTS PC104Plus boards.

Astrometry With the Hubble Space Telescope: Trigonometric Parallaxes of Planetary Nebula Nuclei NGC 6853, NGC 7293, ABELL 31, and DeHt 5

NASA Technical Reports Server (NTRS)

Benedict, G. F.; McArthur, Barbara E.; Napiwotzki, Ralf; Harrison, Thomas E.; Harris, Hugh C.; Nelan, Edmund; Bond, Howard E; Patterson, Richard J.; Ciardullo, Robin

2009-01-01

We present absolute parallaxes and relative proper motions for the central stars of the planetary nebulae NGC 6853 (The Dumbbell), NGC 7293 (The Helix), Abell 31, and DeHt 5. This paper details our reduction and analysis using DeHt 5 as an example. We obtain these planetary nebula nuclei (PNNi) parallaxes with astrometric data from Fine Guidance Sensors FGS 1r and FGS 3, white-light interferometers on the Hubble Space Telescope. Proper motions, spectral classifications and VJHKT2M and DDO51 photometry of the stars comprising the astrometric reference frames provide spectrophotometric estimates of reference star absolute parallaxes. Introducing these into our model as observations with error, we determine absolute parallaxes for each PNN. Weighted averaging with previous independent parallax measurements yields an average parallax precision, sigma (sub pi)/ pi = 5%. Derived distances are: d(sub NGC6853) = 405(exp +28 sub -25) pc, d(sub NGC7293) = 216(exp +14 sub -12) pc, d(sub Abell31) = 621(exp +91 sub -70) pc, and d(sub DeHt5) = 345(exp +19 sub -17) pc. These PNNi distances are all smaller than previously derived from spectroscopic analyses of the central stars. To obtain absolute magnitudes from these distances requires estimates of interstellar extinction. We average extinction measurements culled from the literature, from reddening based on PNNi intrinsic colors derived from model SEDs, and an assumption that each PNN experiences the same rate of extinction as a function of distance as do the reference stars nearest (in angular separation) to each central star. We also apply Lutz-Kelker bias corrections. The absolute magnitudes and effective temperatures permit estimates of PNNi radii through both the Stefan-Boltzmann relation and Eddington fluxes. Comparing absolute magnitudes with post-AGB models provides mass estimates. Masses cluster around 0.57 solar Mass, close to the peak of the white dwarf mass distribution. Adding a few more PNNi with well-determined distances and masses, we compare all the PNNi with cooler white dwarfs of similar mass, and confirm, as expected, that PNNi have larger radii than white dwarfs that have reached their final cooling tracks.

10 CFR 51.91 - Final environmental impact statement-contents.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Final environmental impact statement-contents. 51.91 Section 51.91 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR DOMESTIC LICENSING AND RELATED REGULATORY FUNCTIONS National Environmental Policy Act-Regulations...

U.S. Geological Survey and Microsoft Cooperative Research and Development Agreement: Geospatial Data Browsing and Retrieval Site on the World Wide Web

USGS Publications Warehouse

,

1999-01-01

In May 1997, the U.S. Geological Survey (USGS) and the Microsoft Corporation of Redmond, Wash., entered into a cooperative research and development agreement (CRADA) to make vast amounts of geospatial data available to the general public through the Internet. The CRADA is a 36-month joint effort to develop a general, public-oriented browsing and retrieval site for geospatial data on the Internet. Specifically, Microsoft plans to (1) modify a large volume of USGS geospatial data so the images can be displayed quickly and easily over the Internet, (2) implement an easy-to-use interface for low-speed connections, and (3) develop an Internet Web site capable of servicing millions of users per day.

U.S. Geological Survey and Microsoft Cooperative Research and Development Agreement: Geospatial Data Browsing and Retrieval Site on the World Wide Web

USGS Publications Warehouse

,

1998-01-01

In May 1997, the U.S. Geological Survey (USGS) and the Microsoft Corporation of Redmond, Wash., entered into a cooperative research and development agreement (CRADA) to make vast amounts of geospatial data available to the general public through the Internet. The CRADA is a 36-month joint effort to develop a general, public-oriented browsing and retrieval site for geospatial data on the Internet. Specifically, Microsoft plans to (1) modify a large volume of USGS geospatial data so the images can be displayed quickly and easily over the Internet, (2) implement an easy-to-use interface for low-speed connections, and (3) develop an Internet Web site capable of servicing millions of users per day.

The Role of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer: A Prospective Cohort Study.

PubMed

Saito, Tomotaka; Hirano, Kenji; Isayama, Hiroyuki; Nakai, Yousuke; Saito, Kei; Umefune, Gyotane; Akiyama, Dai; Watanabe, Takeo; Takagi, Kaoru; Hamada, Tsuyoshi; Takahara, Naminatsu; Uchino, Rie; Mizuno, Suguru; Kogure, Hirofumi; Matsubara, Saburo; Yamamoto, Natsuyo; Tada, Minoru; Koike, Kazuhiko

2017-03-01

Although patients with pancreatic cancer (PC) are prone to exocrine pancreatic insufficiency, there are little evidence about pancreatic enzyme replacement therapy (PERT) in patients with PC, especially those receiving chemotherapy. This is a prospective consecutive observational study of PERT in patients with unresectable PC. We prospectively enrolled patients receiving chemotherapy for unresectable PC from April 2012 to February 2014 and prescribed oral pancrelipase of 48,000 lipase units per meal (pancrelipase group). N-benzoyl-tryrosyl para-aminobenzoic acid test was performed at baseline. Patients receiving chemotherapy before April 2012 were retrospectively studied as a historical cohort. Data on the nutritional markers at baseline and 16 weeks were extracted, and serial changes, defined as the ratio of markers at 16 weeks/baseline, were compared between 2 groups. A total of 91 patients (46 in the pancrelipase group and 45 in the historical cohort) were analyzed. N-benzoyl-tryrosyl para-aminobenzoic acid test was low in 94% of the pancrelipase group. Serial change in the pancrelipase group versus historical cohort was 1.01 versus 0.95 in body mass index (P < 0.001) and 1.03 versus 0.97 in serum albumin (P = 0.131). The rate of exocrine pancreatic insufficiency in unresectable PC was high, and PERT can potentially improve the nutritional status during chemotherapy.

Reconstructing merger timelines using star cluster age distributions: the case of MCG+08-11-002

NASA Astrophysics Data System (ADS)

Davies, Rebecca L.; Medling, Anne M.; U, Vivian; Max, Claire E.; Sanders, David; Kewley, Lisa J.

2016-05-01

We present near-infrared imaging and integral field spectroscopy of the centre of the dusty luminous infrared galaxy merger MCG+08-11-002, taken using the Near InfraRed Camera 2 (NIRC2) and the OH-Suppressing InfraRed Imaging Spectrograph (OSIRIS) on Keck II. We achieve a spatial resolution of ˜25 pc in the K band, allowing us to resolve 41 star clusters in the NIRC2 images. We calculate the ages of 22/25 star clusters within the OSIRIS field using the equivalent widths of the CO 2.3 μm absorption feature and the Br γ nebular emission line. The star cluster age distribution has a clear peak at ages ≲ 20 Myr, indicative of current starburst activity associated with the final coalescence of the progenitor galaxies. There is a possible second peak at ˜65 Myr which may be a product of the previous close passage of the galaxy nuclei. We fit single and double starburst models to the star cluster age distribution and use Monte Carlo sampling combined with two-sided Kolmogorov-Smirnov tests to calculate the probability that the observed data are drawn from each of the best-fitting distributions. There is a >90 per cent chance that the data are drawn from either a single or double starburst star formation history, but stochastic sampling prevents us from distinguishing between the two scenarios. Our analysis of MCG+08-11-002 indicates that star cluster age distributions provide valuable insights into the timelines of galaxy interactions and may therefore play an important role in the future development of precise merger stage classification systems.

Application of Short Screening Tools for Post-Traumatic Stress Disorder in the Korean Elderly Population

PubMed Central

Jang, Yu Jin; Chung, Hae Gyung; Choi, Jin Hee; Kim, Tae Yong; So, Hyung Seok

2016-01-01

Objective Post-traumatic stress disorder (PTSD) is often missed or incorrectly diagnosed in primary care settings. Although brief screening instruments may be useful in detecting PTSD, an adequate validation study has not been conducted with older adults. This study aimed to evaluate the reliability and validity of the Korean version of the primary care PTSD screen (PC-PTSD) and single-item PTSD screener (SIPS) in elderly veterans. Methods The PC-PTSD and SIPS assessments were translated into Korean, with a back-translation to the original language to verify accuracy. Vietnamese war veterans [separated into a PTSD group (n=41) and a non-PTSD group (n=99)] participated in several psychometric assessments, including the Korean versions of the PC-PTSD (PC-PTSD-K), SIPS (SIPS-K), a structured clinical interview from the Diagnostic and Statistical Manual of Mental Disorders-IV(SCID), and PTSD checklist(PCL). Results The PC-PTSD-K showed high internal consistency (Cronbach α=0.76), and the test-retest reliability of the PC-PTSD-K and SIPS-K were also high (r=0.97 and r=0.91, respectively). A total score of 3 from the PC-PTSD-K yielded the highest diagnostic efficiency, with sensitivity and specificity values of 0.90 and 0.86, respectively. The 'bothered a lot' response level from the SIPS-K showed the highest diagnostic efficiency, with sensitivity and specificity values of 0.85 and 0.89, respectively. Conclusion Our findings suggest that both PC-PTSD-K and SIPS-K have good psychometric properties with high validity and reliability for detecting PTSD symptoms in elderly Korean veterans. However, further research will be necessary to increase our understanding of PTSD characteristics in diverse groups with different types of trauma. PMID:27482241

Synthesis, Spectral and Photophysical Properties of Anthracene Substituted Phthalocyanines; A Study as Polyurethane Electrospun Nanofibers.

PubMed

Ku, Kyo-Sun; Kumar, Rangaraju Satish; Son, Young-A

2018-03-01

We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work. For this synthesis, we started from base-catalysed aromatic displacement reaction of 4-nitrophthalonitrile with 9-hydroxyanthracene. The resulting four phthalocyanines (PCs) have been fully characterized by a series of spectroscopic methods including electronic absorption, elemental analysis, MALDI-TOF mass, and IR spectroscopy. The aggregation behavior of these PCs was investigated in different concentrations of chloroform solution. Further thermal stability also investigated by TG analysis. Finally we successfully made phthalocyanine (PC1) blended polyurethane electrospun (ES) nanofibers.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Edwin S.

Under the CRADA, NREL will provide assistance to NRGsim to debug and convert the EnergyPlus Hysteresis Phase Change Material ('PCM') model to C++ for adoption into the main code package of the EnergyPlus simulation engine.

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

PubMed Central

Zhang, Weidong; Randell, Edward W.; Sun, Guang; Likhodii, Sergei; Liu, Ming; Furey, Andrew

2017-01-01

To test whether type 2 diabetic patients have an elevated level of advanced glycation end-products (AGEs) and responsible for altered phosphatidylcholine metabolism, which we recently found to be associated with osteoarthritis (OA) and diabetes mellitus (DM), synovial fluid (SF) and plasma samples were collected from OA patients with and without DM. Hyperglycemia-related AGEs including methylglyoxal (MG), free methylglyoxal-derived hydroimidazolone (MG-H1), and protein bound N-(Carboxymethyl)lysine (CML) and N-(Carboxyethyl)lysine (CEL) levels were measured in both SF and plasma samples using liquid chromatography coupled tandem mass spectrometry methodology. The correlation between these AGEs and phosphatidylcholine acyl-alkyl C34:3 (PC ae C34:3) and C36:3 (PC ae C36:3) were examined. Eighty four patients with knee OA, including 46 with DM and 38 without DM, were included in the study. There was no significant difference in plasma levels of MG, MG-H1, CML, and CEL between OA patients with and without DM. However, the levels of MG and MG-H1, but not CML and CEL in SF were significantly higher in OA patients with DM than in those without (all p ≤0.04). This association strengthened after adjustment for age, body mass index (BMI), sex and hexose level (p<0.02). Moreover, the levels of MG-H1 in SF was negatively and significantly correlated with PC ae C34:3 (ρ = -0.34; p = 0.02) and PC ae C36:3 (ρ = -0.39; P = 0.03) after the adjustment of age, BMI, sex and hexose level. Our data indicated that the production of non-protein bound AGEs was increased within the OA-affected joint of DM patients. This is associated with changes in phosphatidylcholine metabolism and might be responsible for the observed epidemiological association between OA and DM. PMID:28898260

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications.

PubMed

Wang, Wei; Qin, Jiang-Jiang; Voruganti, Sukesh; Nag, Subhasree; Zhou, Jianwei; Zhang, Ruiwen

2015-11-01

Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial developmental and physiological processes in the cell. More recently, they have been found to play important roles in human carcinogenesis and cancer development and progression. The deregulation and dysfunction of PcG proteins often lead to blocking or inappropriate activation of developmental pathways, enhancing cellular proliferation, inhibiting apoptosis, and increasing the cancer stem cell population. Genetic and molecular investigations of PcG proteins have long been focused on their PcG functions. However, PcG proteins have recently been shown to exert non-classical-Pc-functions, contributing to the regulation of diverse cellular functions. We and others have demonstrated that PcG proteins regulate the expression and function of several oncogenes and tumor suppressor genes in a PcG-independent manner, and PcG proteins are associated with the survival of patients with cancer. In this review, we summarize the recent advances in the research on PcG proteins, including both the Pc-repressive and non-classical-Pc-functions. We specifically focus on the mechanisms by which PcG proteins play roles in cancer initiation, development, and progression. Finally, we discuss the potential value of PcG proteins as molecular biomarkers for the diagnosis and prognosis of cancer, and as molecular targets for cancer therapy. © 2015 Wiley Periodicals, Inc.

JPRS Report Science & Technology USSR: Chemistry

DTIC Science & Technology

1991-08-29

EXPLOSIVES Cryostatic Problems at Temperatures Below 2 K. Part 2. Analysis of Principal Refrigerator Designs //. F. Kuzmenko; KHIMICHESKOYEINEFTYANOYE...VOLOKNA, No 1, Jan 91] 24 Eperimental Method for Evaluating Quality of Core-Shell Interface in Polymeric Light Conductors [M. A. Maryukov...No 3, Mar 91 pp 178-179 [Article by Yu. S. Ivchenko] UDC 66.023.002.237:66.063.8 [Abstract] An attempt was made to design a universal apparatus

Pharmacokinetics, dose proportionality and permeability of S002-333 and its enantiomers, a potent antithrombotic agent, in rabbits.

PubMed

Saxena, Amrita; Valicherla, Guru R; Joshi, Pankaj; Saxena, Rohit; Cheruvu, Srikanth H; Bhunia, Shome S; Jain, Girish K; Siddiqui, Hefazat H; Saxena, Anil K; Gayen, Jiaur R

2015-01-01

1. S002-333 [(2-(4'-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-pyrido (3,4-b) indole-3-carboxylic acid amide)] is a novel and potent antithrombotic active agent. The present work investigates the pharmacokinetics, bioavailability, dose proportionality and permeability of the racemate, S002-333 in male New Zealand White (NZW) rabbits. 2. Rabbits were administered single intravenous (i.v.) (2 mg/kg) and three oral doses of 10, 20 and 40 mg/kg of S002-333, respectively, at different occasions to evaluate dose proportionality. Serial blood samples were collected and analyzed by a liquid chromatography tandem mass spectrometry (LC-MS/MS) method. Since S002-333 is a racemate consisting of S004-1032 (R) and S007-1558 (S), same samples were analyzed using a chiralcel column so as to evaluate the respective enantiomers. 3. The peak plasma concentration, after oral administration, occurred at ∼10 h post-dose. The clearance (CL) and volume of distribution (Vd) after i.v. dose were found to be 3.05 ± 0.09 l/h/kg and 6.73 ± 1.16 l/kg, respectively. The absolute oral bioavailability of S002-333 was 16.32%, whereas it was 6.62 and 5.90% for R- and S-enantiomers, respectively. The absolute bioavailability of 10, 20 and 40 mg/kg doses were found to be 27.91, 14.39 and 16.91%, respectively. The PAMPA (parallel artificial membrane permeability assay) assay shows that S002-333 has a low-passive permeability at gastric and intestinal environment. 4. In conclusion, S002-333 has low-passive permeability, low CL and large Vd. The R-enantiomer has a "slightly" greater bioavailability than the S-enantiomer.

Investigation of natural phosphatidylcholine sources: separation and identification by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS2) of molecular species.

PubMed

Le Grandois, Julie; Marchioni, Eric; Zhao, Minjie; Giuffrida, Francesca; Ennahar, Saïd; Bindler, Françoise

2009-07-22

This study is a contribution to the exploration of natural phospholipid (PL) sources rich in long-chain polyunsaturated fatty acids (LC-PUFAs) with nutritional interest. Phosphatidylcholines (PCs) were purified from total lipid extracts of different food matrices, and their molecular species were separated and identified by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS(2)). Fragmentation of lithiated adducts allowed for the identification of fatty acids linked to the glycerol backbone. Soy PC was particularly rich in species containing essential fatty acids, such as (18:2-18:2)PC (34.0%), (16:0-18:2)PC (20.8%), and (18:1-18:2)PC (16.3%). PC from animal sources (ox liver and egg yolk) contained major molecular species, such as (16:0-18:2)PC, (16:0-18:1)PC, (18:0-18:2)PC, or (18:0-18:1)PC. Finally, marine source (krill oil), which was particularly rich in (16:0-20:5)PC and (16:0-22:6)PC, appeared to be an interesting potential source for food supplementation with LC-PUFA-PLs, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Allelic distribution of human leucocyte antigen in historical and recently diagnosed tuberculosis patients in Southern Italy.

PubMed

Ruggiero, Giuseppina; Cosentini, Elena; Zanzi, Delia; Sanna, Veronica; Terrazzano, Giuseppe; Matarese, Giuseppe; Sanduzzi, Alessandro; Perna, Francesco; Zappacosta, Serafino

2004-03-01

This study addresses the analysis of the human leucocyte antigen (HLA) allele distribution in 54 historical and in 68 recently diagnosed tuberculosis (TB) patients. The historical cohort was characterized by the presence of large fibrocavernous lesions effectively treated with therapeutic pneumothorax during the period 1950-55. Patients and healthy controls enrolled in the study were from the Campania region of southern Italy. No significant association between HLA alleles and TB in the population of recently diagnosed TB patients was observed. On the contrary, among the historical TB patients there was a strong association with an increased frequency of the HLA-DR4 allele alone and/or in the presence of the HLA-B14 allele (P = 0.000004; Pc = 0.0008), as well as with a decreased frequency of the HLA-A2+,-B14-,DR4- allele association (P = 0.00005; Pc = 0.01). In order to exclude any interference from age-related factors, these results were confirmed by comparing the historical cohort of TB patients with an age-matched healthy control population of the same ethnic origin (P = 0.00004; Pc = 0.008; and P = 0.0001; and Pc = 0.02, respectively).

10 CFR 51.91 - Final environmental impact statement-contents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... comment is discussed individually in the text of the statement. (3) If changes in the draft environmental... 10 Energy 2 2011-01-01 2011-01-01 false Final environmental impact statement-contents. 51.91 Section 51.91 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR...

Cancer of the ovary, fallopian tube, and peritoneum: a population-based comparison of the prognostic factors and outcomes.

PubMed

Rottmann, Miriam; Burges, A; Mahner, S; Anthuber, C; Beck, T; Grab, D; Schnelzer, A; Kiechle, M; Mayr, D; Pölcher, M; Schubert-Fritschle, G; Engel, J

2017-09-01

The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of the Munich Cancer Registry (meanwhile 4.8 million inhabitants). Tumour site differences were examined by comparing prognostic factors, treatments, the time to progression, and survival. The effect of the tumour site was additionally analysed by a Cox regression model. The median age at diagnosis, histology, and FIGO stage significantly differed among the tumour sites (p < 0.001); PC patients were older, more often diagnosed with a serous subtype, and in FIGO stage III or IV. The time to progression and survival significantly differed among the tumour sites. When stratified by FIGO stage, the differences in time to progression disappeared, and the differences in survival considerably weakened. The differences in the multivariate survival analysis showed an almost identical outcome in PC patients (HR 1.07 [0.91-1.25]) and an improved survival of FC patients (HR 0.63 [0.49-0.81]) compared to that of OC patients. The comparison of OC, FC, and PC patients in this large-scale population-based study showed differences in the prognostic factors. These differences primarily account for the inferior outcome of PC patients, and for the improved survival of FC compared to OC patients.

NGAL, MIC-1 and CA19-9 in Pancreatic Juice: Pathobiological Implications in Diagnosing Benign and Malignant Disease of the Pancreas

PubMed Central

KAUR, SUKHWINDER; BAINE, MICHAEL J.; GUHA, SUSHOVAN; OCHI, NOBUO; CHAKRABORTY, SUBHANKAR; MALLYA, KAVITA; THOMAS, COLLEEN; CROOK, JULIA; WALLACE, MICHAEL B.; WOODWARD, TIMOTHY A.; JAIN, MANEESH; SINGH, SHAILENDER; SASSON, AARON R.; SKINNER, VERNA; RAIMONDO, MASSIMO; BATRA, SURINDER K.

2012-01-01

Objective Pancreatic diseases pose significant diagnostic challenge as signs and symptoms often overlap. We investigated the potential of pancreatic juice neutrophil gelatinase–associated lipocalin (NGAL), macrophage inhibitory cytokine-1 (MIC-1), and carbohydrate antigen 19-9 (CA19-9) to aid in the diagnosis of patients with symptoms suggestive of pancreatic diseases. Methods 105 chronic pancreatitis (CP), pancreatic cancer (PC), and non-pancreatic non-healthy (NPNH, patients with symptoms mimicking pancreatic disease but found to be free of pancreatic pathology) patients underwent endoscopic pancreatic juice collection following secretin-stimulation. NGAL and MIC-1 levels were measured by enzyme-linked immunosorbent assay while CA19-9 was measured by radioimmunoassay. Results NGAL, MIC-1, and CA19-9 were significantly elevated in the pancreatic juice of CP and PC patients as compared to NPNH controls (p<0.034). NGAL appeared most promising in differentiating diseased versus non-diseased pancreata (AUCs=0.88–0.91) while MIC-1 was found to be higher in PC than CP patients (p=0.043). Interestingly, MIC-1 levels in diabetic PC patients were higher than in non-diabetic PC (p=0.030) and diabetic CP patients (p=0.087). CA19-9 showed the least ability to distinguish patient groups (AUCs=0.61–0.76). Conclusions Pancreatic juice NGAL shows potential utility in establishing pancreatic etiology in the context of non-specific symptoms while MIC-1 may aid in differentiating PC from CP. PMID:23146921

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

PubMed Central

Wang, Wei; Qin, Jiang-Jiang; Voruganti, Sukesh; Nag, Subhasree; Zhou, Jianwei; Zhang, Ruiwen

2016-01-01

Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial developmental and physiological processes in the cell. More recently, they have been found to play important roles in human carcinogenesis and cancer development and progression. The deregulation and dysfunction of PcG proteins often lead to blocking or inappropriate activation of developmental pathways, enhancing cellular proliferation, inhibiting apoptosis, and increasing the cancer stem cell population. Genetic and molecular investigations of PcG proteins have long been focused on their PcG functions. However, PcG proteins have recently been shown to exert non-polycomb functions, contributing to the regulation of diverse cellular functions. We and others have demonstrated that PcG proteins regulate the expression and function of several oncogenes and tumor suppressor genes in a PcG-independent manner, and PcG proteins are associated with the survival of patients with cancer. In this review, we summarize the recent advances in the research on PcG proteins, including both the polycomb-repressive and non-polycomb functions. We specifically focus on the mechanisms by which PcG proteins play roles in cancer initiation, development, and progression. Finally, we discuss the potential value of PcG proteins as molecular biomarkers for the diagnosis and prognosis of cancer, and as molecular targets for cancer therapy. PMID:26227500

RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.

PubMed

Satijn, D P; Gunster, M J; van der Vlag, J; Hamer, K M; Schul, W; Alkema, M J; Saurin, A J; Freemont, P S; van Driel, R; Otte, A P

1997-07-01

The Polycomb (Pc) protein is a component of a multimeric, chromatin-associated Polycomb group (PcG) protein complex, which is involved in stable repression of gene activity. The identities of components of the PcG protein complex are largely unknown. In a two-hybrid screen with a vertebrate Pc homolog as a target, we identify the human RING1 protein as interacting with Pc. RING1 is a protein that contains the RING finger motif, a specific zinc-binding domain, which is found in many regulatory proteins. So far, the function of the RING1 protein has remained enigmatic. Here, we show that RING1 coimmunoprecipitates with a human Pc homolog, the vertebrate PcG protein BMI1, and HPH1, a human homolog of the PcG protein Polyhomeotic (Ph). Also, RING1 colocalizes with these vertebrate PcG proteins in nuclear domains of SW480 human colorectal adenocarcinoma and Saos-2 human osteosarcoma cells. Finally, we show that RING1, like Pc, is able to repress gene activity when targeted to a reporter gene. Our findings indicate that RING1 is associated with the human PcG protein complex and that RING1, like PcG proteins, can act as a transcriptional repressor.

Phase Error Correction in Time-Averaged 3D Phase Contrast Magnetic Resonance Imaging of the Cerebral Vasculature

PubMed Central

MacDonald, M. Ethan; Forkert, Nils D.; Pike, G. Bruce; Frayne, Richard

2016-01-01

Purpose Volume flow rate (VFR) measurements based on phase contrast (PC)-magnetic resonance (MR) imaging datasets have spatially varying bias due to eddy current induced phase errors. The purpose of this study was to assess the impact of phase errors in time averaged PC-MR imaging of the cerebral vasculature and explore the effects of three common correction schemes (local bias correction (LBC), local polynomial correction (LPC), and whole brain polynomial correction (WBPC)). Methods Measurements of the eddy current induced phase error from a static phantom were first obtained. In thirty healthy human subjects, the methods were then assessed in background tissue to determine if local phase offsets could be removed. Finally, the techniques were used to correct VFR measurements in cerebral vessels and compared statistically. Results In the phantom, phase error was measured to be <2.1 ml/s per pixel and the bias was reduced with the correction schemes. In background tissue, the bias was significantly reduced, by 65.6% (LBC), 58.4% (LPC) and 47.7% (WBPC) (p < 0.001 across all schemes). Correction did not lead to significantly different VFR measurements in the vessels (p = 0.997). In the vessel measurements, the three correction schemes led to flow measurement differences of -0.04 ± 0.05 ml/s, 0.09 ± 0.16 ml/s, and -0.02 ± 0.06 ml/s. Although there was an improvement in background measurements with correction, there was no statistical difference between the three correction schemes (p = 0.242 in background and p = 0.738 in vessels). Conclusions While eddy current induced phase errors can vary between hardware and sequence configurations, our results showed that the impact is small in a typical brain PC-MR protocol and does not have a significant effect on VFR measurements in cerebral vessels. PMID:26910600

Development of Interpretable Predictive Models for BPH and Prostate Cancer.

PubMed

Bermejo, Pablo; Vivo, Alicia; Tárraga, Pedro J; Rodríguez-Montes, J A

2015-01-01

Traditional methods for deciding whether to recommend a patient for a prostate biopsy are based on cut-off levels of stand-alone markers such as prostate-specific antigen (PSA) or any of its derivatives. However, in the last decade we have seen the increasing use of predictive models that combine, in a non-linear manner, several predictives that are better able to predict prostate cancer (PC), but these fail to help the clinician to distinguish between PC and benign prostate hyperplasia (BPH) patients. We construct two new models that are capable of predicting both PC and BPH. An observational study was performed on 150 patients with PSA ≥3 ng/mL and age >50 years. We built a decision tree and a logistic regression model, validated with the leave-one-out methodology, in order to predict PC or BPH, or reject both. Statistical dependence with PC and BPH was found for prostate volume (P-value < 0.001), PSA (P-value < 0.001), international prostate symptom score (IPSS; P-value < 0.001), digital rectal examination (DRE; P-value < 0.001), age (P-value < 0.002), antecedents (P-value < 0.006), and meat consumption (P-value < 0.08). The two predictive models that were constructed selected a subset of these, namely, volume, PSA, DRE, and IPSS, obtaining an area under the ROC curve (AUC) between 72% and 80% for both PC and BPH prediction. PSA and volume together help to build predictive models that accurately distinguish among PC, BPH, and patients without any of these pathologies. Our decision tree and logistic regression models outperform the AUC obtained in the compared studies. Using these models as decision support, the number of unnecessary biopsies might be significantly reduced.

An Investigation of Siloxane Cross-linked Hydroxyapatite-Gelatin/Copolymer Composites for Potential Orthopedic Applications†

PubMed Central

Dyke, Jason Christopher; Knight, Kelly Jane; Zhou, Huaxing; Chiu, Chi-Kai; Ko, Ching-Chang; You, Wei

2012-01-01

Causes of bone deficiency are numerous, but biomimetic alloplastic grafts provide an alternative to repair tissue naturally. Previously, a hydroxyapatite-gelatin modified siloxane (HAp-Gemosil) composite was prepared by cross-linking (N, N′-bis[(3-trimethoxysilyl)propyl]ethylene diamine (enTMOS) around the HAp-Gel nanocomposite particles, to mimic the natural composition and properties of bone. However, the tensile strength remained too low for many orthopedic applications. It was hypothesized that incorporating a polymer chain into the composite could help improve long range interaction. Furthermore, designing this polymer to interact with the enTMOS siloxane cross-linked matrix would provide improved adhesion between the polymer and the ceramic composite, and improve mechanical properties. To this end, copolymers of L-Lactide (LLA), and a novel alkyne derivatized trimethylene carbonate, propargyl carbonate (PC), were synthesized. Incorporation of PC during copolymerization affects properties of copolymers such as molecular weight, Tg, and % PC incorporation. More importantly, PC monomers bear a synthetic handle, allowing copolymers to undergo post-polymerization functionalization with graft monomers to specifically tailor the properties of the final composite. For our investigation, P(LLA-co-PC) copolymers were functionalized by an azido-silane (AS) via copper catalyzed azide-alkyne cycloaddition (CuAAC) through terminal alkyne on PC monomers. The new functionalized polymer, P(LLA-co-PC)(AS) was blended with HAp-Gemosil, with the azido-silane linking the copolymer to the silsesquioxane matrix within the final composite. These HAp-Gemosil/P(LLA-co-PC)(AS) composites were subjected to mechanical and biological testing, and the results were compared with those from the HAp-Gemosil composites. This study revealed that incorporating a cross-linkable polymer served to increase the flexural strength of the composite by 50%, while maintaining the biocompatibility of HAp-Gemosil ceramics. PMID:23139457

Substrate analysis of the Pneumocystis carinii protein kinases PcCbk1 and PcSte20 using yeast proteome microarrays provides a novel method for Pneumocystis signalling biology.

PubMed

Kottom, Theodore J; Limper, Andrew H

2011-10-01

Pneumocystis carinii (Pc) undergoes morphological transitions between cysts and trophic forms. We have previously described two Pc serine/threonine kinases, termed PcCbk1 and PcSte20, with PcSte20 belonging to a family of kinases involved in yeast mating, while PcCbk1 is a member of a group of protein kinases involved in regulation of cell cycle, shape, and proliferation. As Pc remains genetically intractable, knowledge on specific substrates phosphorylated by these kinases remains limited. Utilizing the phylogenetic relatedness of Pc to Saccharomyces cerevisiae, we interrogated a yeast proteome microarray containing >4000 purified protein based peptides, leading to the identification of 18 potential PcCbk1 and 15 PcSte20 substrates (Z-score > 3.0). A number of these potential protein substrates are involved in bud site selection, polarized growth, and response to mating α factor and pseudohyphal and invasive growth. Full-length open reading frames suggested by the PcCbk1 and PcSte20 protoarrays were amplified and expressed. These five proteins were used as substrates for PcCbk1 or PcSte20, with each being highly phosphorylated by the respective kinase. Finally, to demonstrate the utility of this method to identify novel PcCbk1 and PcSte20 substrates, we analysed DNA sequence data from the partially complete Pc genome database and detected partial sequence information of potential PcCbk1 kinase substrates PcPxl1 and PcInt1. We additionally identified the potential PcSte20 kinase substrate PcBdf2. Full-length Pc substrates were cloned and expressed in yeast, and shown to be phosphorylated by the respective Pc kinases. In conclusion, the yeast protein microarray represents a novel crossover technique for identifying unique potential Pc kinase substrates. Copyright © 2011 John Wiley & Sons, Ltd.

Array Effects in Large Wind Farms. Cooperative Research and Development Final Report, CRADA Number CRD-09-343

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moriarty, Patrick

2016-02-23

The effects of wind turbine wakes within operating wind farms have a substantial impact on the overall energy production from the farm. The current generation of models drastically underpredicts the impact of these wakes leading to non-conservative estimates of energy capture and financial losses to wind farm operators and developers. To improve these models, detailed research of operating wind farms is necessary. Rebecca Barthelmie of Indiana University is a world leader of wind farm wakes effects and would like to partner with NREL to help improve wind farm modeling by gathering additional wind farm data, develop better models and increasemore » collaboration with European researchers working in the same area. This is currently an active area of research at NREL and the capabilities of both parties should mesh nicely.« less

Development of Rotational Accelerometers Final Report CRADA No. TSB-2008-99

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunter, S.; Crosson, R.

One of the difficulties in fabricating an inexpensive angular rate or rotation sensor is producing a device that is insensitive to acceleration, including the constant acceleration of gravity. The majority of rate sensors are either tuning fork type devices sensing a relatively weak force (i.e., Coriolis effect) and thus not very sensitive, or gyroscopes (either rotating or fiber optic based) that are large, consume lots of power and are expensive. This project was a collaborative effort between LLNL and The Fredericks Company to develop a rotational sensor as a standardized, commercial product. The Fredericks Company possessed expertise and capabilities inmore » the technical aspects of manufacturing this type of sensor, and they were interested in collaborating with LLNL to manufacture the rotational rate sensors as a commercial product.« less

Electromagnetic Simulations for Aerospace Application Final Report CRADA No. TC-0376-92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madsen, N.; Meredith, S.

Electromagnetic (EM) simulation tools play an important role in the design cycle, allowing optimization of a design before it is fabricated for testing. The purpose of this cooperative project was to provide Lockheed with state-of-the-art electromagnetic (EM) simulation software that will enable the optimal design of the next generation of low-observable (LO) military aircraft through the VHF regime. More particularly, the project was principally code development and validation, its goal to produce a 3-D, conforming grid,time-domain (TD) EM simulation tool, consisting of a mesh generator, a DS13D-based simulation kernel, and an RCS postprocessor, which was useful in the optimization ofmore » LO aircraft, both for full-aircraft simulations run on a massively parallel computer and for small scale problems run on a UNIX workstation.« less

Cellulosic Biomass Sugars to Advantage Jet Fuel: Catalytic Conversion of Corn Stover to Energy Dense, Low Freeze Point Paraffins and Naphthenes: Cooperative Research and Development Final Report, CRADA Number CRD-12-462

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elander, Rick

NREL will provide scientific and engineering support to Virent Energy Systems in three technical areas: Process Development/Biomass Deconstruction; Catalyst Fundamentals; and Technoeconomic Analysis. The overarching objective of this project is to develop the first fully integrated process that can convert a lignocellulosic feedstock (e.g., corn stover) efficiently and cost effectively to a mix of hydrocarbons ideally suited for blending into jet fuel. The proposed project will investigate the integration of Virent Energy System’s novel aqueous phase reforming (APR) catalytic conversion technology (BioForming®) with deconstruction technologies being investigated by NREL at the 1-500L scale. Corn stover was chosen as a representativemore » large volume, sustainable feedstock.« less

Commercialization of LLNL Zinc Air Fuel Cell Technology For Stationary And Mobile Applications And Electromechanical Battery For Mobile Applications Final Report CRADA No. TC-1420-97

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tokarz, F. J.; Cooper, J. F.; Haley, D.

Utility deregulation is occurring throughout the world. Energy storage, peak demand leveling and power quality are becoming increasingly important. New, innovative costeffective methods are critical to the financial success or failure of utility companies in the new free market environment. The implementation of energy storage gives a utility the ability to better utilize existing generating capacity. Energy is stored in the periods of low overall demand and then the stored energy is connected to the power grid during peak demand periods. Storing energy in this manner will lead to significant economic benefits to utilities as well as their customers. Furthermore,more » because the utility's system is operated more efficiently there is a direct reduction in atmospheric pollutants including greenhouse gases.« less

Application of Vacancy Injection Gettering to Improve Efficiency of Solar Cells Produced by Millinet Solar: Cooperative Research and Development Final Report, CRADA Number CRD-10-417

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sopori, B.

2012-07-01

NREL will apply vacancy injection gettering (VIG) to Millinet solar cells and evaluate the performance improvement produced by this process step. The VIG will be done in conjunction with the formation of a back, Al-alloyed, contact. Millinet Solar will provide NREL with cells having AR coating on the front side and screen-printed Al on the backside, which will be processed in the NREL's optical furnace to perform simultaneous VIG and back contact alloying with deep BSF. These cells will be sent back to Millinet solar for a screen-printed front/side contact mask, followed by a second firing at NREL. Detailed analysesmore » will be performed to determine improvements due to BSF and VIG.« less

Development of Kinetics and Mathematical Models for High-Pressure Gasification of Lignite-Switchgrass Blends: Cooperative Research and Development Final Report, CRADA Number CRD-11-447

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iisa, Kristiina

2016-04-06

NREL will work with Participant as a subtier partner under DE-FOA-0000240 titled "Co-Production of Power, Fuels, and Chemicals via Coal/Biomass Mixtures." The goal of the project is to determine the gasification characteristics of switchgrass and lignite mixtures and develop kinetic models. NREL will utilize a pressurized thermogravimetric analyzer to measure the reactivity of chars generated in a pressurized entrained-flow reactor at Participant's facilities and to determine the evolution of gaseous species during pyrolysis of switchgrass-lignite mixtures. Mass spectrometry and Fourier-transform infrared analysis will be used to identify and quantify the gaseous species. The results of the project will aid inmore » defining key reactive properties of mixed coal biomass fuels.« less

NREL Helps Industry Partner Commercialize Promising Technology For Forest

Science.gov Websites

development agreement (CRADA) with Minerals Technologies, Inc. of Bethlehem, Penn. to conduct research to -shared research agreement is designed to provide Minerals Technologies, Inc. access to NREL's research

48 CFR 970.5227-2 - Rights in data-technology transfer.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Research and Development Agreement (CRADA) information in accordance with Technology Transfer actions under... descriptive of the data and is suitable for dissemination purposes, (B) The program under which it was funded...

48 CFR 970.5227-2 - Rights in data-technology transfer.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Research and Development Agreement (CRADA) information in accordance with Technology Transfer actions under... descriptive of the data and is suitable for dissemination purposes, (B) The program under which it was funded...

48 CFR 970.5227-2 - Rights in data-technology transfer.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Research and Development Agreement (CRADA) information in accordance with Technology Transfer actions under... descriptive of the data and is suitable for dissemination purposes, (B) The program under which it was funded...

48 CFR 970.5227-2 - Rights in data-technology transfer.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Research and Development Agreement (CRADA) information in accordance with Technology Transfer actions under... descriptive of the data and is suitable for dissemination purposes, (B) The program under which it was funded...

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

This quarterly report summarizes the status for the project planning to complete all the legal and contract documents required for establishing the subcontracts needed and a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). During the second quarter (1/1/2013 to 3/31/2013), all the technical and legal documents for the subcontracts to Purdue University, University of Illinois, and PlastiComp, Inc. were completed. The revised CRADA documents were sent to DOE, Autodesk, Toyota, and Magna for technical and legal reviews. PNNL Legal Services contacted project partners’more » Legal counterparts for completing legal documents for the project. A non-disclosure agreement was revised and sent to all the parties for reviews.« less

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Simmons, Kevin L.

This quarterly report summarizes the status for the project planning to initiate all the legal and contract documents required for establishing the subcontracts needed and a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). During the first quarter (10/1/2012 to 12/31/2012), the statements of work (SOW) for the subcontracts to Purdue University, University of Illinois, and PlastiComp, Inc. were completed. A draft of the CRADA SOW was sent to Autodesk, Toyota, and Magna for technical and legal reviews. PNNL Legal Services contacted project partners’more » Legal counterparts for preparing legal documents for the project. A non-disclosure agreement was drafted and sent to all the parties for reviews.« less

Search for and follow-up imaging of subparsec accretion disks in AGN

NASA Astrophysics Data System (ADS)

Kondratko, Paul Thomas

We report results of several large surveys for water maser emission among Active Galactic Nuclei with the 100-m Green Bank Telescope and the two NASA Deep Space Network 70-m antennas at Tidbinbilla, Australia and at Robledo, Spain. We detected 23 new sources, which resulted in a 60% increase in the number of then known nuclear water maser sources. Eight new detections show the characteristic spectral signature of emission from an edge-on accretion disk and therefore constitute good candidates for the determination of black hole mass and geometric distance. This increase in the number of known sources has enabled us to reconsider statistical properties of the resulting sample. For the 30 water maser sources with available hard X-ray data, we found a possible correlation between unabsorbed X-ray luminosity (2-10 keV) and total isotropic water maser luminosity of the form L 2-10 0([Special characters omitted.] , consistent with the model proposed by Neufeld et al. (1994) in which X-ray irradiation of molecular accretion disk gas by the central engine excites the maser emission. We mapped for the first time with Very Long Baseline Interferomatey (VLBI) the full extent of the pc-scale accretion disk in NGC 3079 as traced by water maser emission. Positions and line-of-sight velocities of maser emission are consistent with a nearly edge-on pc-scale disk and a central mass of ~ 2 x 10^6 [Special characters omitted.] enclosed within ~ 0.4 pc. Based on the kinematics of the system, we propose that the disk is geometrically-thick, massive, subject to gravitational instabilities, and hence most likely clumpy and star- forming. The accretion disk in NGC 3079 is thus markedly different from the compact, thin, warped, differentially rotating disk in the archetypal maser galaxy NGC 4258. We also detect maser emission at high latitudes above the disk and suggest that it traces an inward extension of the kpc-scale bipolar wide- angle outflow previously observed along the galactic minor axis. We also report the first VLBI map of the pc-scale accretion disk in NGC 3393. Water maser emission in this source appears to follow Keplerian rotation and traces a linear structure between disk radii of 0.36 and ~ 1 pc. Assuming an edge-on disk and Keplerian rotation, the inferred central mass is (3.1±0.2) × 10^7 [Special characters omitted.] enclosed within 0.36±0.02 pc, which corresponds to a mean mass density of ~ 10 8.2 [Special characters omitted.] pc -3 . We also measured with the Green Bank Telescope centripetal acceleration within the disk, from which we infer the disk radius of 0.17±0.02 pc for the maser feature that is located along the line of sight to the dynamical center. This emission evidently occurs much closer to the center than the emission from the disk midline (0.17 vs. 0.36 pc), contrary to the situation in the two archetypal maser systems NGC 4258 and NGC 1068.

Changing Patterns of Mental Health Care Use: The Role of Integrated Mental Health Services in Veteran Affairs Primary Care.

PubMed

Leung, Lucinda B; Yoon, Jean; Rubenstein, Lisa V; Post, Edward P; Metzger, Maureen E; Wells, Kenneth B; Sugar, Catherine A; Escarce, José J

2018-01-01

Aiming to foster timely, high-quality mental health care for Veterans, VA's Primary Care-Mental Health Integration (PC-MHI) embeds mental health specialists in primary care and promotes care management for depression. PC-MHI and patient-centered medical home providers work together to provide the bulk of mental health care for primary care patients with low-to-moderate-complexity mental health conditions. This study examines whether increasing primary care clinic engagement in PC-MHI services is associated with changes in patient health care utilization and costs. We performed a retrospective longitudinal cohort study of primary care patients with identified mental health needs in 29 Southern California VA clinics from October 1, 2008 to September 30, 2013, using electronic administrative data (n = 66,638). We calculated clinic PC-MHI engagement as the proportion of patients receiving PC-MHI services among all primary care clinic patients in each year. Capitalizing on variation in PC-MHI engagement across clinics, our multivariable regression models predicted annual patient use of 1) non-primary care based mental health specialty (MHS) visits, 2) total mental health visits (ie, the sum of MHS and PC-MHI visits), and 3) health care utilization and costs. We controlled for year- and clinic-fixed effects, other clinic interventions, and patient characteristics. Median clinic PC-MHI engagement increased by 8.2 percentage points over 5 years. At any given year, patients treated at a clinic with 1 percentage-point higher PC-MHI engagement was associated with 0.5% more total mental health visits (CI, 0.18% to 0.90%; P = .003) and 1.0% fewer MHS visits (CI, -1.6% to -0.3%; P = .002); this is a substitution rate, at the mean, of 1.5 PC-MHI visits for each MHS visit. There was no PC-MHI effect on other health care utilization and costs. As intended, greater clinic engagement in PC-MHI services seems to increase realized accessibility to mental health care for primary care patients, substituting PC-MHI for MHS visits, without increasing acute care use or total costs. Thus, PC-MHI services within primary care clinics may improve mental health care value at the patient population level. More research is needed to understand the relationship between clinic PC-MHI engagement and clinical quality of mental health care. © Copyright 2018 by the American Board of Family Medicine.

KSC-91PC-0265

NASA Image and Video Library

1991-02-20

Vice President of the United States Dan Quayle, right, tries on a communications headset in the Launch Control Center and learns about firing room activities from Launch Director Robert Sieck. Quayle spoke with members of the STS-39 flight crew participating in the Terminal Countdown Demonstration Test, toured the launch pad and other center facilities, addressed workers and held a press conference. Image credit: NASA

C II forbidden-line 158 micron mapping in Sagittarius A Rotation curve and mass distribution in the galactic center

NASA Technical Reports Server (NTRS)

Lugten, J. B.; Genzel, R.; Crawford, M. K.; Townes, C. H.

1986-01-01

Based on data obtained with the NASA Kuiper Airborne Observatory 91.4 cm telescope, the 158-micron fine structure line emission of C(+) is mapped near the galactic center. The strongest emission comes from a 10-pc FWHM diameter disk centered on Sgr A West whose dominant motion is rotation. Extended C(+) emission is also found from the +50 km/s galactic center molecular cloud, and a second cloud at v(LSR) of about -35 km/s. The rotation curve and mass distribution within 10 pc of the galactic center are derived, and the C(+) profiles show a drop-off of rotation velocity between 2 and 10 pc. A mass model is suggested with 2-4 million solar masses in a central point mass, and a M/L ratio of the central stellar cluster of 0.5 solar masses/solar luminosities, suggesting a large abundance of giants and relatively recent star formation in the center.

Adsorption of metal-phthalocyanine molecules onto the Si(111) surface passivated by δ doping: Ab initio calculations

NASA Astrophysics Data System (ADS)

Veiga, R. G. A.; Miwa, R. H.; McLean, A. B.

2016-03-01

We report first-principles calculations of the energetic stability and electronic properties of metal-phthalocyanine (MPc) molecules (M = Cr, Mn, Fe, Co, Ni, Cu, and Zn) adsorbed on the δ -doped Si(111)-B (√{3 }×√{3 }) reconstructed surface. (i) It can be seen that CrPc, MnPc, FePc, and CoPc are chemically anchored to the topmost Si atom. (ii) Contrastingly, the binding of the NiPc, CuPc, and ZnPc molecules to the Si (111 ) -B (√{3 }×√{3 }) surface is exclusively ruled by van der Waals interactions, the main implication being that these molecules may diffuse and rearrange to form clusters and/or self-organized structures on this surface. The electronic structure calculations reveal that in point (i), owing to the formation of the metal-Si covalent bond, the net magnetic moment of the molecule is quenched by 1 μB , remaining unchanged in point (ii). In particular, the magnetic moment of CuPc (1 μB ) is preserved after adsorption. Finally, we verify that the formation of ZnPc, CuPc, and NiPc molecular (self-assembled) arrangements on the Si(111)-B (√{3 }×√{3 } ) surface is energetically favorable, in good agreement with recent experimental findings.

Safety and efficacy of percutaneous cecostomy/colostomy for treatment of large bowel obstruction in adults with cancer.

PubMed

Tewari, Sanjit O; Getrajdman, George I; Petre, Elena N; Sofocleous, Constantinos T; Siegelbaum, Robert H; Erinjeri, Joseph P; Weiser, Martin R; Thornton, Raymond H

2015-02-01

To assess the safety and efficacy of image-guided percutaneous cecostomy/colostomy (PC) in the management of colonic obstruction in patients with cancer. Twenty-seven consecutive patients underwent image-guided PC to relieve large bowel obstruction at a single institution between 2000 and 2012. Colonic obstruction was the common indication. Patient demographics, diagnosis, procedural details, and outcomes including maximum colonic distension (MCD; ie, greatest transverse measurement of the colon on radiograph or scout computed tomography image) were recorded and retrospectively analyzed. Following PC, no patient experienced colonic perforation; pain was relieved in 24 of 27 patients (89%). Catheters with tip position in luminal gas rather than mixed stool/gas or stool were associated with greater decrease in MCD (-40%, -12%, and -16%, respectively), with the difference reaching statistical significance (P = .002 and P = .013, respectively). Catheter size was not associated with change in MCD (P = .978). Catheters were successfully removed from six of nine patients (67%) with functional obstructions and two of 18 patients (11%) with mechanical obstructions. One patient underwent endoscopic stent placement after catheter removal. Three patients required diverting colostomy after PC, and their catheters were removed at the time of surgery. One major complication (3.7%; subcutaneous emphysema, pneumomediastinum, and sepsis) occurred 8 days after PC and was successfully treated with cecostomy exchange, soft-tissue drainage, and intravenous antibiotic therapy. Image-guided PC is safe and effective for management of functional and mechanical bowel obstruction in patients with cancer. For optimal efficacy, catheters should terminate within luminal gas. Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.

Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer.

PubMed

Mahon, K L; Lin, H-M; Castillo, L; Lee, B Y; Lee-Ng, M; Chatfield, M D; Chiam, K; Breit, S N; Brown, D A; Molloy, M P; Marx, G M; Pavlakis, N; Boyer, M J; Stockler, M R; Daly, R J; Henshall, S M; Horvath, L G

2015-04-14

Docetaxel improves symptoms and survival in metastatic castration-resistant prostate cancer (CRPC). However, ∼50% of patients are chemoresistant. This study examined whether changes in cytokine levels predict for docetaxel resistance in vitro and in a clinical cohort. PC3 cells or their docetaxel-resistant subline (PC3Rx) were co-cultured with U937 monocytes, with and without docetaxel treatment, and cytokine levels were measured. The circulating levels of 28 cytokines were measured pre-/post cycle 1 of docetaxel from 55 men with CRPC, and compared with prostate-specific antigen (PSA) response. PC3Rx-U937 co-culture expressed more cytokines, chiefly markers of alternative macrophage differentiation, compared with PC3-U937 co-culture. Docetaxel treatment enhanced cytokine production by PC3Rx-U937 co-culture, while reducing cytokine levels in PC3-U937. In patients, changes in the levels of seven circulating cytokines (macrophage inhibitory cytokine 1 (MIC1), interleukin (IL)-1ra, IL-1β, IL-4, IL-6, IL-12 and IFNγ) after cycle 1 of docetaxel were associated with progressive disease (all P<0.05). The combination of changes in MIC1, IL-4 and IL-6 most strongly predicted PSA response (P=0.002). In vitro studies suggest docetaxel resistance is mediated, at least in part, by cytokines induced by the interaction between the docetaxel-resistant tumour cells and macrophages. Early changes in circulating cytokine levels were associated with docetaxel resistance in CRPC patients. When considered together, these data suggest a significant role for the inflammatory response and macrophages in the development of docetaxel resistance in CRPC.

Partial wave spectroscopic microscopy can predict prostate cancer progression and mitigate over-treatment (Conference Presentation)

NASA Astrophysics Data System (ADS)

Zhang, Di; Graff, Taylor; Crawford, Susan; Subramanian, Hariharan; Thompson, Sebastian; Derbas, Justin R.; Lyengar, Radha; Roy, Hemant K.; Brendler, Charles B.; Backman, Vadim

2016-02-01

Prostate Cancer (PC) is the second leading cause of cancer deaths in American men. While prostate specific antigen (PSA) test has been widely used for screening PC, >60% of the PSA detected cancers are indolent, leading to unnecessary clinical interventions. An alternative approach, active surveillance (AS), also suffer from high expense, discomfort and complications associated with repeat biopsies (every 1-3 years), limiting its acceptance. Hence, a technique that can differentiate indolent from aggressive PC would attenuate the harms from over-treatment. Combining microscopy with spectroscopy, our group has developed partial wave spectroscopic (PWS) microscopy, which can quantify intracellular nanoscale organizations (e.g. chromatin structures) that are not accessible by conventional microscopy. PWS microscopy has previously been shown to predict the risk of cancer in seven different organs (N ~ 800 patients). Herein we use PWS measurement of label-free histologically-normal prostatic epithelium to distinguish indolent from aggressive PC and predict PC risk. Our results from 38 men with low-grade PC indicated that there is a significant increase in progressors compared to non-progressors (p=0.002, effect size=110%, AUC=0.80, sensitivity=88% and specificity=72%), while the baseline clinical characteristics were not significantly different. We further improved the diagnostic power by performing nuclei-specific measurements using an automated system that separates in real-time the cell nuclei from the remaining prostate epithelium. In the long term, we envision that the PWS based prognostication can be coupled with AS without any change to the current procedure to mitigate the harms caused by over-treatment.

Binuclear Phthalocyanines as Model Electrocatalysts for the Reduction of Oxygen.

DTIC Science & Technology

1985-05-01

solution, in which case the final product is Co(II)Pc. Aqueous acid addition (under nitrogen) to Co(I)Pc (in DCB/OH-) yields Co(II)Pc and presumably hydrogen ...little doubt, given the tendency for Co(I) to reduce aqueous acid to hydrogen [101, that hydrogen is produced in this reaction, though it was not proven...reduction occurs in water by a 2-electron process to hydrogen peroxide or a 4-electron process to water. This latter process must be catalysed on a

Significance of serum total prostate specific antigen and digital rectal examination in the diagnosis of prostate cancer.

PubMed

Abdrabo, Abdelkarim A; Fadlalla, Adil I; Fadl-Elmula, Imad M

2011-11-01

To assess the significance of serum total prostate specific antigen (tPSA) and digital rectal examination (DRE) in the diagnosis of prostate cancer (PC). One hundred and eighteen patients with serum tPSA ranging between 2.5 and 10 ng/ml with lower urinary tract symptoms presented at the Urology Clinic of Soba University Hospital, Khartoum, Sudan from August 2008 and January 2010 were included in the study. Serum tPSA was measured using enzyme immunoassay method, and accordingly, the patients were classified into 2 groups: patients that had tPSA between 2.5-4.0 ng/ml; and patients that had tPSA between 4.1-10 ng/ml. The DRE was performed on all patients by a qualified urologist, and were recorded as a group with suspicion of PC, and a group with no suspicion of PC. All patients underwent transrectal sextant prostate biopsy. The DRE alone showed 63.8% sensitivity and 68% specificity with 46.9% positive predictive value (PPV) for the diagnosis of PC. The tPSA test revealed 91.6% sensitivity and 24% specificity with PPV of 34%. However, when combining DRE and tPSA, the sensitivity reached 100% and the specificity increased to 92% with PPV of 49%. Combining DRE and tPSA test increases the sensitivity, specificity, and PPV of PC detection.

Model of Oxygen and Glucose Deprivation in PC12 Cells and Detection of HSP70 Protein

NASA Astrophysics Data System (ADS)

He, Jinting; Yang, Le; Shao, Yankun

2018-01-01

Objective: PC12 cell was used to set up a ischemia model by OGD and detected HSP70 protein. Methods: Use of PC12 cells induced by NGF stimulation into nerve cells, oxygen and glucose deprivation to build the nerve cells of oxygen and glucose deprivation model; using Western blot analysis of PC12 cells into neuron-like cells and oxygen-glucose deprivation model established. Results: The application of a final concentration of 50 ng / ml of NGF in DMEM complete mediumPC12 cells showed a typical neuronal morphology with the increase in cell culture time. NGF culture time showed a positive correlation, the establishment of oxygen and glucose deprivation (OGD) training environment, the OGD after nerve element appears different degrees of damage, OGD can effectively induce the expression of HSP70. Conclusion: PC12 cell transformed into cells by NGF; the cell model of OGD was established.

Sandia National Laboratories:

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New Browse Technology Portfolios Technology Partnerships Business, Industry, & Non-Profits Government

Dinutuximab (Unituxin™) | NCI Technology Transfer Center | TTC

Cancer.gov

In 2010, NCI entered into a Cooperative Research and Development Agreement (CRADA) with United Therapeutics Corp., under which the company assumed responsibility for manufacturing dinutuximab and moving it through the steps required for regulatory approval.

Long-term outcome of permanent hemodialysis catheters: a controlled study.

PubMed

Jean, G; Charra, B; Chazot, C; Vanel, T; Terrat, J C; Hurot, J M

2001-01-01

Hemodialysis tunneled catheters are widely used nowadays. However, their complications, infection and dysfunction, remain much too frequent. Different types of tunneled silicone hemodialysis catheters are available. We prospectively compared the long-term outcome of the two most popular devices, Permcath cuffed double catheter and TwinCath uncuffed twin catheter, both inserted percutaneously. From January 1994 to April 1998, 125 tunneled catheters were inserted in the internal jugular vein of 86 chronic hemodialysis patients, 63 TwinCath MedComp (TC) and 62 Permcath Quinton (PC). They were prospectively followed looking for technical patency, infection and dysfunction rate. TC were used more often for iterative access (52 vs. 25%, p = 0.01) and were inserted more frequently in the left internal jugular vein (59 vs. 16% p < 0.001). Their median technical survival rate was longer (869 vs. 433 days for PC, p < 0.01) with a 1-year patency rate of 80 vs. 53% (p = 0.002). Total catheter extrusion was also slightly less frequent with TC (4.7 vs. 9.6%), but partial extrusion happened more frequently (43 vs. 16%, p = 0.02). No significant difference in infection rate was observed, 0.77 for TC vs. 1.3 local infection/1,000 catheter days; 1.08 vs. 1.30 bacteremia/1,000 catheter days. A persistent catheter thrombosis was observed in 7.9 vs. 20.9% in PC (p = 0.04), the number of dysfunction was 10.5 vs. 24/1,000 days in use (p = 0.0001) and the number of urokinase infusion was 4.4 vs. 12/1,000 days (p = 0.001). PC needed more radiological interventions for dysfunction with endolumenal brushes (4 vs. 0) or fibrin sleeve removal (4 vs. 0). The vena cava thrombosis incidence was not different (2 vs. 3). Although the study was not randomized, TC appears more efficient allowing for a longer patency with a lower dysfunction rate than PC. This was reinforced by less favorable conditions of TC including more left jugular side and more iterative catheters. The cuff does not offer a better bacteriological barrier or protection against extrusion, and the TC seems at a less risk of fibrin sleeves. However, a large randomized study is needed to definitively conclude. Copyright 2001 S. Karger AG, Basel

Biological applications of phase-contrast electron microscopy.

PubMed

Nagayama, Kuniaki

2014-01-01

Here, I review the principles and applications of phase-contrast electron microscopy using phase plates. First, I develop the principle of phase contrast based on a minimal model of microscopy, introducing a double Fourier-transform process to mathematically formulate the image formation. Next, I explain four phase-contrast (PC) schemes, defocus PC, Zernike PC, Hilbert differential contrast, and schlieren optics, as image-filtering processes in the context of the minimal model, with particular emphases on the Zernike PC and corresponding Zernike phase plates. Finally, I review applications of Zernike PC cryo-electron microscopy to biological systems such as protein molecules, virus particles, and cells, including single-particle analysis to delineate three-dimensional (3D) structures of protein and virus particles and cryo-electron tomography to reconstruct 3D images of complex protein systems and cells.

Differential expression of steroid 5alpha-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer.

PubMed

Das, Kakoli; Lorena, Pia D N; Ng, Lai Kuan; Lim, Diana; Shen, Liang; Siow, Woei Yun; Teh, Ming; Reichardt, Juergen K V; Salto-Tellez, Manuel

2010-09-01

The biological role of steroid 5alpha-reductase isozymes (encoded by the SRD5A1 and SRD5A2 genes) and angiogenic factors that play important roles in the pathogenesis and vascularization of prostate cancer (PC) is poorly understood. The sub-cellular expression of these isozymes and vascular endothelial growth factor (VEGF) in PC tissue microarrays (n=62) was examined using immunohistochemistry. The effect of SRD5A inhibition on the angiogenesis pathway genes in PC was also examined in prostate cell lines, LNCaP, PC3, and RWPE-1, by treating them with the SRD5A inhibitors finasteride and dutasteride, followed by western blot, quantitative PCR, and ELISA chip array techniques. In PC tissues, nuclear SRD5A1 expression was strongly associated with higher cancer Gleason scores (P=0.02), higher cancer stage (P=0.01), and higher serum prostate specific antigen (PSA) levels (P=0.01), whereas nuclear SRD5A2 expression was correlated with VEGF expression (P=0.01). Prostate tumor cell viability was significantly reduced in dutasteride-treated PC3 and RWPE-1 cells compared with finasteride-treated groups. Expression of the angiogenesis pathway genes transforming growth factor beta 1 (TGFB1), endothelin (EDN1), TGFalpha (TGFA), and VEGFR1 was upregulated in LNCaP cells, and at least 7 out of 21 genes were upregulated in PC3 cells treated with finasteride (25 muM). Our findings suggest that SRD5A1 expression predominates in advanced PC, and that inhibition of SRD5A1 and SRD5A2 together was more effective in reducing cell numbers than inhibition of SRD5A2 alone. However, these inhibitors did not show any significant difference in prostate cell angiogenic response. Interestingly, some angiogenic genes remained activated after treatment, possibly due to the duration of treatment and tumor resistance to inhibitors.

The performance of blended conventional and novel binders in the in-situ stabilisation/solidification of a contaminated site soil.

PubMed

Wang, Fei; Wang, Hailing; Jin, Fei; Al-Tabbaa, Abir

2015-03-21

This paper presents an investigation of the effects of novel binders and pH values on the effectiveness of the in-situ stabilisation/solidification technique in treating heavy metals and organic contaminated soils after 1.5-year treatment. To evaluate the performance of different binders, made ground soils of SMiRT site, upto 5 m depth, were stabilised/solidified with the triple auger system and cores were taken for laboratory testing after treatment. Twenty four different binders were used including Portland cement (PC), ground granulated blastfurnace slag (GGBS), pulverised fuel ash (PFA), MgO and zeolite. Unconfined compressive strength (UCS), leachate pH and the leachability of heavy metals and total organics were applied to study the behaviours of binders in treating site soils. Under various contaminant level and binder level, the results show that UCS values were 22-3476 kPa, the leachability of the total organics was in the range of 22-241 mg/l and the heavy metals was in the range of 0.002-0.225 mg/l. In addition, the combination of GGBS and MgO at a ratio of 9:1 shows better immobilisation efficiency in treating heavy metals and organic contaminated soils after 1.5-year treatment, and the binding mechanisms under different binders were also discussed in this paper. Copyright © 2014 Elsevier B.V. All rights reserved.

Final Environmental Assessment for Force Structure Changes at Langley Air Force Base, VA

DTIC Science & Technology

2011-10-01

Shepard Blvd, Hampton, VA, 23665, DEQ PC No. 20095002, PC Case Status - Release Confirmed, Case Closed. Langley Air Force Base- Building 333, 90 Oak...NOISEXPO ‘77, Chicago , IL. March. White, R. 1972. Effects of Repetitive Sonic Booms on Glass Breakage. FAA Report FAA-RD-72- 43. April. 6

Enhanced cell apoptosis triggered by a multi modal mesoporous amphiphilic drug delivery system

NASA Astrophysics Data System (ADS)

Pradhan, Lina; Srivastava, R.; Bahadur, D.

2015-11-01

Mesoporous magnetic nanoparticles (MMNPs) have been synthesized through a facile soft chemical route and are conjugated with multiple therapeutic agents. These MMNPs have the ability to contain and deliver both hydrophilic and hydrophobic drugs simultaneously with the mediation of an AC magnetic field (ACMF). Furthermore, the synthesis and characterization of doxorubicin hydrochloride:paclitaxel (DOX:TXL) and doxorubicin hydrochloride:cisplatin (DOX:Cis-Pt) conjugates are demonstrated. MMNPs show an excellent loading efficiency of ˜96:83% (DOX:TXL) and ˜93:83% (DOX:Cis-Pt) along with a loading capacity of ˜0.002:0.002 mg mg-1 (DOX:TXL) and ˜0.002:0.002 mg mg-1 (DOX:Cis-Pt), respectively. Over a period of 180 h, a sustained release of drugs is observed and shows a better efficiency at pH 4.3 (˜85:63%-DOX:TXL and ˜86:73%-DOX:Cis-Pt) compared to that under physiological pH conditions (˜28:22%-DOX:TXL and ˜26:22%-DOX:Cis-Pt). The MMNPs can release ˜37:22% (DOX:TXL) and ˜34:25% (DOX:Cis-Pt) within 30 min when triggered by an ACMF (at ˜43 °C). The in vitro cytotoxic effect, the ROS generation level and cell cycle distribution analysis of DOX:TXL-MMNPs and DOX:Cis-Pt-MMNPs treated MDA-MB231, MCF-7 and PC3 cancer cells are demonstrated. Enhanced cell apoptosis is observed by thermo-chemotherapy which includes application of an ACMF for 15 min. Specifically, DOX:TXL-MMNPs are more effective than DOX:Cis-Pt-MMNPs towards the PC3 cell line. The internalization of multiple drug loaded MMNPs by cells and their morphological changes due to thermo-chemotherapy are confirmed through confocal microscopy. From the present results, it is observed that the DOX:TXL and DOX:Cis-Pt conjugated MMNPs, under an ACMF, can readily minimize drug resistance. This has significantly enhanced the cell apoptosis of target cancer cells.

Microchip-based Integration of Cell Immobilization, Electrophoresis, Post-column Derivatization, and Fluorescence Detection for Monitoring the Release of Dopamine from PC 12 Cells

PubMed Central

Li, Michelle W.; Martin, R. Scott

2008-01-01

In this paper, we describe the fabrication and evaluation of a multilayer microchip device that can be used to quantitatively measure the amount of catecholamines released from PC 12 cells immobilized within the same device. This approach allows immobilized cells to be stimulated on-chip and, through rapid actuation of integrated microvalves, the products released from the cells are repeatedly injected into the electrophoresis portion of the microchip, where the analytes are separated based upon mass and charge and detected through post-column derivatization and fluorescence detection. Following optimization of the post-column derivatization detection scheme (using naphthalene-2,3-dicarboxaldehyde and 2-β-mercaptoethanol), off-chip cell stimulation experiments were performed to demonstrate the ability of this device to detect dopamine from a population of PC 12 cells. The final 3-dimensional device that integrates an immobilized PC 12 cell reactor with the bilayer continuous flow sampling/electrophoresis microchip was used to continuously monitor the on-chip stimulated release of dopamine from PC 12 cells. Similar dopamine release was seen when stimulating on-chip versus off-chip yet the on-chip immobilization studies could be carried out with 500 times fewer cells in a much reduced volume. While this paper is focused on PC 12 cells and neurotransmitter analysis, the final device is a general analytical tool that is amenable to immobilization of a variety of cell lines and analysis of various released analytes by electrophoretic means. PMID:18810283

Diagnostic accuracy of a two-item Drug Abuse Screening Test (DAST-2).

PubMed

Tiet, Quyen Q; Leyva, Yani E; Moos, Rudolf H; Smith, Brandy

2017-11-01

Drug use is prevalent and costly to society, but individuals with drug use disorders (DUDs) are under-diagnosed and under-treated, particularly in primary care (PC) settings. Drug screening instruments have been developed to identify patients with DUDs and facilitate treatment. The Drug Abuse Screening Test (DAST) is one of the most well-known drug screening instruments. However, similar to many such instruments, it is too long for routine use in busy PC settings. This study developed and validated a briefer and more practical DAST for busy PC settings. We recruited 1300 PC patients in two Department of Veterans Affairs (VA) clinics. Participants responded to a structured diagnostic interview. We randomly selected half of the sample to develop and the other half to validate the new instrument. We employed signal detection techniques to select the best DAST items to identify DUDs (based on the MINI) and negative consequences of drug use (measured by the Inventory of Drug Use Consequences). Performance indicators were calculated. The two-item DAST (DAST-2) was 97% sensitive and 91% specific for DUDs in the development sample and 95% sensitive and 89% specific in the validation sample. It was highly sensitive and specific for DUD and negative consequences of drug use in subgroups of patients, including gender, age, race/ethnicity, marital status, educational level, and posttraumatic stress disorder status. The DAST-2 is an appropriate drug screening instrument for routine use in PC settings in the VA and may be applicable in broader range of PC clinics. Published by Elsevier Ltd.

Oral gastrografin radiography for the evaluation of the functional impact of peritoneal carcinomatosis: Correlation with clinicopathological findings

PubMed Central

MEI, LIE-JUN; WANG, LIN-WEI; HUANG, CHAO-QUN; YANG, XIAO-JUN; LI, YAN

2015-01-01

This study was conducted to evaluate the functional impact of peritoneal carcinomatosis (PC) on the gastrointestinal system by oral gastrografin radiography (OGR). OGR was performed on 105 patients with PC from abdominal malignancies. The OGR characteristics were analyzed and compared with intraoperative observations. OGR provided real-time dynamic information on the functional impacts of PC. The OGR findings were normal in 9 (8.6%) and abnormal in 96 (91.4%) cases. In terms of frequency, 33 cases (31.4%) exhibited mild intestinal aggregation and flattening of the intestinal mucosa; 29 cases (27.6%) exhibited limited intestinal invasion, marginally stenotic small bowel and mucosal deformities; 26 cases (24.8%) exhibited only mild mesenteric contracture and mild slowing of gastrointestinal peristalsis; 5 cases (4.8%) exhibited obvious mesenteric contracture, ball-like changes, fixed position and disappearance of the intestinal mucosa; 2 cases (1.9%) exhibited complete pyloric obstruction; and 1 case (0.9%) exhibited duodenal obstruction. Gastric PC was associated with a higher percentage of stomach filling defects and small intestinal aggregates compared with PC from other malignancies (P<0.01 for both). In 87 cases, the ORG findings were in accordance with the intraoperative findings (κ=0.726, P<0.001), whereas 17 cases (16.2%) were underestimated and 1 (0.9%) was overestimated by OGR. This study indicated that OGR may be a useful technique for the evaluation of the functional impacts of PC on the gastrointestinal system and may help optimize the selection of patients for treatment. PMID:26623037

Image analysis of hardened concrete : performance enhancement of the Automated Concrete Evaluation System (ACES).

DOT National Transportation Integrated Search

2006-01-01

Since 2001, the Missouri Department of Transportation and National Nuclear Security Administrations Kansas City Plant, : operated by Honeywell Federal Manufacturing & Technologies, have collaborated on three CRADAs (Cooperative : Research and D...

GREEN REACTION CHEMISTRIES PERFORMED IN THE SST REACTOR

EPA Science Inventory

The U. S. Environmental Protection Agency (USEPA) and Kreido Laboratories have established a Cooperative Research and Development Agreement (CRADA) collaboration, to develop and commercialize green and sustainable chemistries in the area of industrial chemical synthesis. Uti...

Halaven® - eribulin mesylate (analog of halichondrin B) | NCI Technology Transfer Center | TTC

Cancer.gov

Under a CRADA with NCI, Eisai Co. provided eribulin for NCI's preclinical development activities and to support NCI's Phase I clinical trials. Eisai ultimately took the product, Halaven®, to licensure.

10 CFR 784.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... contracts, grants, agreements, understandings and other arrangements (including Cooperative Research and Development Agreements [CRADAs], Work for Others and User Facility agreements, which includes research, development, or demonstration work, and includes any assignment or substitution of the parties, entered into...

Utility of Big Area Additive Manufacturing (BAAM) For The Rapid Manufacture of Customized Electric Vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Love, Lonnie J.

This Oak Ridge National Laboratory (ORNL) Manufacturing Development Facility (MDF) technical collaboration project was conducted in two phases as a CRADA with Local Motors Inc. Phase 1 was previously reported as Advanced Manufacturing of Complex Cyber Mechanical Devices through Community Engagement and Micro-manufacturing and demonstrated the integration of components onto a prototype body part for a vehicle. Phase 2 was reported as Utility of Big Area Additive Manufacturing (BAAM) for the Rapid Manufacture of Customized Electric Vehicles and demonstrated the high profile live printing of an all-electric vehicle using ONRL s Big Area Additive Manufacturing (BAAM) technology. This demonstration generatedmore » considerable national attention and successfully demonstrated the capabilities of the BAAM system as developed by ORNL and Cincinnati, Inc. and the feasibility of additive manufacturing of a full scale electric vehicle as envisioned by the CRADA partner Local Motors, Inc.« less

Ultraviolet observations of cool stars. VIII - Interstellar matter toward Procyon

NASA Technical Reports Server (NTRS)

Anderson, R. C.; Henry, R. C.; Moos, H. W.; Linsky, J. L.

1978-01-01

The profile of the chromospheric L-alpha emission line of the F5 IV-V star Procyon (Alpha CMi, d = 3.5 pc) has been measured using the high-resolution Princeton spectrometer aboard NASA's Copernicus satellite. L-alpha absorption lines of interstellar deuterium and hydrogen are distinctly present. The average number density of interstellar hydrogen along the line of sight is found to be 0.11 + or - 0.02 per cu cm, similar to the densities that have been found in the directions of the stars Epsilon Eri, Epsilon Ind, and Alpha Cen A. These stars are all within 3.5 pc of the earth. The ratio of deuterium to hydrogen in the direction of Procyon is found to be 1.3 (+1.2, -0.5) x 10 to the -5th.

Effect of Al Addition on Microstructure of AZ91D

NASA Astrophysics Data System (ADS)

Joshi, Utsavi; Babu, Nadendla Hari

Casting is a net shape or near net shape forming process so work-hardening will not be applicable for improving properties of magnesium cast alloys. Grain refinement, solid-solution strengthening, precipitation hardening and specially designed heat treatment are the techniques used to enhance the properties of these alloys. This research focusses on grain refinement of magnesium alloy AZ91D, which is a widely used commercial cast alloy. Recently, Al-B based master alloys have shown potential in grain refining AZ91D. A comparative study of the grain refinement of AZ91D by addition of 0.02wt%B, 0.04wt%B, 0.1wt%B, 0.5wt%B and 1.0wt%B of A1-5B master alloy and equivalent amount of solute element aluminium is described in this paper. Hardness profile of AZ91D alloyed with boron and aluminium is compared.

KSC-98pc641

NASA Image and Video Library

1998-05-26

Technicians supervise the closure of Discovery's payload bay doors from the Payload Changout Room at Launch Pad 39A as preparations for the STS-91 launch continue. STS-91 is scheduled to be launched on June 2 with a launch window opening around 6:10 p.m. EDT. The mission will feature the ninth Shuttle docking with the Russian Space Station Mir, the first Mir docking for Discovery, the conclusion of Phase I of the joint U.S.-Russian International Space Station Program, and the first flight of the new Space Shuttle super lightweight external tank. The STS-91 flight crew includes Commander Charles Precourt; Pilot Dominic Gorie; and Mission Specialists Wendy B. Lawrence; Franklin Chang-Diaz, Ph.D.; Janet Kavandi, Ph.D.; and Valery Ryumin, with the Russian Space Agency. Andrew Thomas, Ph.D., will be returning to Earth with the crew after living more than four months aboard Mir

KSC-98pc640

NASA Image and Video Library

1998-05-26

Technicians supervise the closure of Discovery's payload bay doors from the Payload Changout Room at Launch Pad 39A as preparations for the STS-91 launch continue. STS-91 is scheduled to be launched on June 2 with a launch window opening around 6:10 p.m. EDT. The mission will feature the ninth Shuttle docking with the Russian Space Station Mir, the first Mir docking for Discovery, the conclusion of Phase I of the joint U.S.-Russian International Space Station Program, and the first flight of the new Space Shuttle super lightweight external tank. The STS-91 flight crew includes Commander Charles Precourt; Pilot Dominic Gorie; and Mission Specialists Wendy B. Lawrence; Franklin Chang-Diaz, Ph.D.; Janet Kavandi, Ph.D.; and Valery Ryumin, with the Russian Space Agency. Andrew Thomas, Ph.D., will be returning to Earth with the crew after living more than four months aboard Mir

KSC-91PC-0264

NASA Image and Video Library

1991-02-20

CAPE CANAVERAL, Fla. -- Vice President of the United States Dan Quayle. right. tries on a communications headset in the Launch Control Center and learns about firing room activities from Launch Director Robert Sieck. Quayle spoke with members of the STS-39 flight crew participating in the Terminal Countdown Demonstration Test, toured the launch pad and other center facilities, addressed workers and held a press conference. Image credit: NASA

Surface Observation Climatic Summaries (SOCS) for Hood AAF, Texas

DTIC Science & Technology

1992-03-01

ASEIVILLE, PC 26001-2723 8. PERFUMING ORGANIZATION REPORT RUlKBER: USAFETAC/DS-92/275 9. SPOS(ORING/MONITORING AGENCY NANE AND ADDRESS: USAF...TX PERIOD OF RECORD: OCT 81 - SEP 91 LEST TO Tl"C: + 6 NORM,: APR HOURS: ALL WIND SPEED IN MOTS DII [CI 1 1-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39

KSC-98pc282

NASA Image and Video Library

1998-02-12

KENNEDY SPACE CENTER, FLA. -- The Space Shuttle's first super lightweight external tank is lifted in KSC's Vehicle Assembly Building for STS-91 pre-flight processing. STS-91 is targeted for launch in late May. The improved tank is 7,500 pounds lighter than its predecessors and was developed to increase the Shuttle payload capacity on International Space Station assembly flights. Major changes to the lighter tank include the use of new materials and a revised internal design. The new liquid oxygen and liquid hydrogen tanks are constructed of aluminum lithium a lighter, stronger material than the metal alloy currently used. The redesigned walls of the liquid hydrogen tank were machined to provide additional strength and stability as well

KSC-98pc283

NASA Image and Video Library

1998-02-12

KENNEDY SPACE CENTER, FLA. -- The Space Shuttle's first super lightweight external tank is lifted in KSC's Vehicle Assembly Building for STS-91 pre-flight processing. STS-91 is targeted for launch in late May. The improved tank is 7,500 pounds lighter than its predecessors and was developed to increase the Shuttle payload capacity on International Space Station assembly flights. Major changes to the lighter tank include the use of new materials and a revised internal design. The new liquid oxygen and liquid hydrogen tanks are constructed of aluminum lithium a lighter, stronger material than the metal alloy currently used. The redesigned walls of the liquid hydrogen tank were machined to provide additional strength and stability as well

KSC-98pc281

NASA Image and Video Library

1998-02-12

KENNEDY SPACE CENTER, FLA. -- The Space Shuttle's first super lightweight external tank is lifted in KSC's Vehicle Assembly Building for STS-91 pre-flight processing. STS-91 is targeted for launch in late May. The improved tank is 7,500 pounds lighter than its predecessors and was developed to increase the Shuttle payload capacity on International Space Station assembly flights. Major changes to the lighter tank include the use of new materials and a revised internal design. The new liquid oxygen and liquid hydrogen tanks are constructed of aluminum lithium a lighter, stronger material than the metal alloy currently used. The redesigned walls of the liquid hydrogen tank were machined to provide additional strength and stability as well

Comparison of Circulating Endothelial Cell/Platelet Count Ratio to Aspartate Transaminase/Platelet Ratio Index for Identifying Patients with Cirrhosis

PubMed Central

Sethi, Saurabh; Simonetto, Douglas A; Abdelmoneim, Soha S; Campion, Michael B; Kaloiani, Irakli; Clayton, Amy C; Kremers, Walter K; Halling, Kevin C; Kamath, Patrick S; Talwalkar, Jayant; Shah, Vijay H

2012-01-01

Background/Objectives Circulating endothelial cells (CECs) are indicative of vascular injury and correlate with severity of vascular diseases. A pilot study showed that the ratio of CEC to platelet count (CEC/PC) was effective in predicting cirrhosis. Therefore, we evaluated CEC/PC in a larger cohort of patients, correlated it with cirrhosis, and compared its operating characteristics with previously described biomarker for cirrhosis, the AST/platelet ratio index (APRI). Methods Fifty-three patients with cirrhosis, 20 matched healthy controls, and 9 patients with noncirrhotic liver disease were recruited. Peripheral blood sample was collected and analyzed to enumerate nucleated CEC CD146+, CD105+, CD45– using a commercial assay. Results Median CEC counts were significantly higher in patients with cirrhosis (62 cells/4 mL, interquartile range [IQR]: 43.5–121) as compared with controls (31 cells/4 mL, IQR: 22.2–40). The CEC/PC was also significantly elevated in cirrhotics (0.69, IQR: 0.39–1.48) compared with controls (0.12, IQR: 0.09–0.20) and noncirrhotics (0.21, IQR: 0.08–0.43). Receiver operator characteristic (ROC) analysis revealed that CEC cutoff value of ≥37 cells/4 mL showed sensitivity of 81% and specificity of 75% for differentiating cirrhosis from controls (area under the curve [AUC]: 0.80; 95% confidence interval [CI] 0.67–0.91). The CEC/PC ratio cutoff value of ≥0.23 showed sensitivity of 91% and specificity of 82% (AUC: 0.92; 95% CI 0.83–0.99). The APRI cutoff value of ≥0.4 showed sensitivity of 94% and specificity of 85% for differentiating cirrhosis from control patients (AUC: 0.96; 95% CI 0.90–1.0). A product of CEC and APRI, termed CAPRI (CEC-APRI), effectively distinguished patients with cirrhosis from controls; with cutoff value of ≥12.7, showing higher sensitivity of 98% and specificity of 85% (AUC: 0.98; 95% CI 0.96–1.0). Conclusion The CEC/PC ratio is significantly elevated in patients with cirrhosis and demonstrates comparable operating characteristics to previously described APRI. Furthermore, CAPRI, compiled as product of CEC to APRI showed outstanding ability to distinguish patients with cirrhosis from controls, although larger studies are necessary for validation. PMID:25755402

Experimental Study on Hot Metal Desulfurization Using Sintered Red Mud-Based Flux

NASA Astrophysics Data System (ADS)

Li, Fengshan; Zhang, Yanling; Guo, Zhancheng

2017-09-01

This research presents the results of laboratory and pilot-scale tests conducted on the use of sintered red mud (RM)-based flux in the hot metal desulfurization (HMD) process. Al2O3/Na2O in RM can decrease the melting point of lime-based slag and can work as a flux in the HMD process. Good slag fluidity was observed throughout the process, and high desulfurization rates ( 80%) with a low final S content (<0.02%) were experimentally obtained when the RM:CaO ratio was between 1.2:1 and 2.4:1. The pilot-scale test results indicated that a desulfurization rate as high as 91% and a S content <0.0099% could be acquired when RM:lime = 1:1, verifying the feasibility of using sintered RM-based flux in HMD. The data obtained provide important information for promoting the large-scale application of sintered RM in steelmaking.

Development of CVD Diamond for Industrial Applications Final Report CRADA No. TC-2047-02

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caplan, M.; Olstad, R.; Jory, H.

2017-09-08

This project was a collaborative effort to develop and demonstrate a new millimeter microwave assisted chemical vapor deposition(CVD) process for manufacturing large diamond disks with greatly reduced processing times and costs from those now available. In the CVD process, carbon based gases (methane) and hydrogen are dissociated into plasma using microwave discharge and then deposited layer by layer as polycrystalline diamond onto a substrate. The available low frequency (2.45GHz) microwave sources used elsewhere (De Beers) result in low density plasmas and low deposition rates: 4 inch diamond disks take 6-8 weeks to process. The new system developed in this projectmore » uses a high frequency 30GHz Gyrotron as the microwave source and a quasi-optical CVD chamber resulting in a much higher density plasma which greatly reduced the diamond processing times (1-2 weeks)« less

Development of a Bio-Equivalent Ultraviolet Dosimeter to Monitor the Capacity for Vitamin D Synthesis of Sunlight Final Report CRADA No. TC02086.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, C. F.; Wood, D.

This project represents a collaborative effort between Lawrence Livermore National Security, LLC as manager and operator of Lawrence Livermore National Laboratory (LLNL) and Rhyolite Technology Group, Inc. (Rhyolite) to develop concepts and designs for a consumer ultraviolet (UV) biodosimeter based on the human biochemistry of Vitamin D synthesis. Rhyolite was established to engage in product development, licensing and consulting for the manufacture and supply of new products worldwide. Rhyolite worked jointly with LLNL and the Kiev Institute of Physics (KIP) in Ukraine to leverage previously developed UV sensor technologies by extending the previous work into commercially viable products. The projectmore » consisted primarily of the scientific, engineering and business activities needed to develop the UV bio-dosimeter for applications that include health and industrial measurement of ultraviolet radiation.« less

Intelligent Manufacturing of Commercial Optics Final Report CRADA No. TC-0313-92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, J. S.; Pollicove, H.

The project combined the research and development efforts of LLNL and the University of Rochester Center for Manufacturing Optics (COM), to develop a new generation of flexible computer controlled optics· grinding machines. COM's principal near term development effort is to commercialize the OPTICAM-SM, a new prototype spherical grinding machine. A crucial requirement for commercializing the OPTICAM-SM is the development of a predictable and repeatable material removal process ( deterministic micro-grinding) that yields high quality surfaces that minimize non-deterministic polishing. OPTICAM machine tools and the fabrication process development studies are part of COM' s response to the DOD (ARPA) request tomore » implement a modernization strategy for revitalizing the U.S. optics manufacturing base. This project was entered into in order to develop a new generation of :flexible, computer-controlled optics grinding machines.« less

Mobile Building Energy Audit and Modeling Tools: Cooperative Research and Development Final Report, CRADA Number CRD-11-00441

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brackney, L.

Broadly accessible, low cost, accurate, and easy-to-use energy auditing tools remain out of reach for managers of the aging U.S. building population (over 80% of U.S. commercial buildings are more than 10 years old*). concept3D and NREL's commercial buildings group will work to translate and extend NREL's existing spreadsheet-based energy auditing tool for a browser-friendly and mobile-computing platform. NREL will also work with concept3D to further develop a prototype geometry capture and materials inference tool operable on a smart phone/pad platform. These tools will be developed to interoperate with NREL's Building Component Library and OpenStudio energy modeling platforms, and willmore » be marketed by concept3D to commercial developers, academic institutions and governmental agencies. concept3D is NREL's lead developer and subcontractor of the Building Component Library.« less

Imperium/Lanzatech Syngas Fermentation Project - Biomass Gasification and Syngas Conditioning for Fermentation Evaluation: Cooperative Research and Development Final Report, CRADA Number CRD-12-474

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilcox, E.

2014-09-01

LanzaTech and NREL will investigate the integration between biomass gasification and LanzaTech's proprietary gas fermentation process to produce ethanol and 2,3-butanediol. Using three feed materials (woody biomass, agricultural residue and herbaceous grass) NREL will produce syngas via steam indirect gasification and syngas conditioning over a range of process relevant operating conditions. The gasification temperature, steam-to-biomass ratio of the biomass feed into the gasifier, and several levels of syngas conditioning (based on temperature) will be varied to produce multiple syngas streams that will be fed directly to 10 liter seed fermenters operating with the Lanzatech organism. The NREL gasification system willmore » then be integrated with LanzaTech's laboratory pilot unit to produce large-scale samples of ethanol and 2,3-butanediol for conversion to fuels and chemicals.« less

Technical Support to SBIR Phase II Project: Improved Conversion of Cellulose Waste to Ethanol Using a Dual Bioreactor System: Cooperative Research and Development Final Report, CRADA Number CRD-08-310

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, M.

2013-04-01

Over-dependence on fossil fuel has spurred research on alternative energy. Inedible plant materials such as grass and corn stover represent abundant renewable natural resources that can be transformed into biofuel. Problems in enzymatic conversion of biomass to sugars include the use of incomplete synergistic enzymes, end-product inhibition, and adsorption and loss of enzymes necessitating their use in large quantities. Technova Corporation will develop a defined consortium of natural microorganisms that will efficiently break down biomass to energy-rich soluble sugars, and convert them to cleaner-burning ethanol fuel. The project will also develop a novel biocatalytic hybrid reactor system dedicated to thismore » bioprocess, which embodies recent advances in nanotechnology. NREL will participate to develop a continuous fermentation process.« less

Process Parameter Evaluation and Optimization for Advanced Material Development Final Report CRADA No. TC-1234-96

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hrubesh, L.; McGann, T. W.

This project was established as a three-year collaboration to produce and characterize · silica aerogels prepared by a Rapid Supercritical Extraction (RSCE) process to meet . BNA, Inc. application requirements. The objectives of this project were to study the parameters necessary to produce optimized aerogel parts with narrowly specified properties and establish the range and limits of the process for producing such aerogels. The project also included development of new aerogel materials useful for high temperature applications. The results of the project were expected to set the conditions necessary to produce quantities of aerogels having particular specifications such as size,more » shape, density, and mechanical strength. BNA, Inc. terminated the project on April 7, 1999, 10-months prior to the anticipated completion date, due to termination of corporate funding for the project. The technical accomplishments achieved are outlined in Paragraph C below.« less

Micropulsations in the electric field near the plasmapause, observed by Isee 1

NASA Technical Reports Server (NTRS)

Moe, T. E.; Maynard, N. C.; Heppner, J. P.

1980-01-01

The results of a survey of occurrence of micropulsations near and inside the plasmapause, made on the basis of 1 year of data from the double probe electric field instrument on Isee 1, are presented. It is reported that the observed pulsations are classified as Pc 3 and P 2, and that one single Pc 1 event is observed. It is found that Pc 3 events are common during the local day, with a maximum percentage of occurrence as high as 72 in the morning hours. Attention is given to Pi 2 events showing that they are concentrated on the local nightside. Finally, it is noted that pulsations in the Pc 1 range appear on only one inbound pass, which makes the Pc 1 a rare phenomenon at low and moderate latitudes in the plasmasphere.

Characteristics and outcomes of patients with advanced cancer evaluated by a palliative care team at an emergency center. A retrospective study.

PubMed

Delgado-Guay, Marvin Omar; Rodriguez-Nunez, Alfredo; Shin, Seong Hoon; Chisholm, Gary; Williams, Janet; Frisbee-Hume, Susan; Bruera, Eduardo

2016-05-01

Patients with advanced cancer may be referred for a palliative care consultation (PC) from a hospital emergency center (EC) or as inpatients. However, research about symptoms and outcomes in patients with advanced cancer who receive PC at the EC is limited. We reviewed demographic variables, frequency and intensity of symptoms (using the Edmonton Symptom Assessment Scale (ESAS)), PC interventions, time from admission to PC consultation, hospitalization duration, and discharge destination of 200 advanced cancer patients referred to PC services from the EC ("EC patients") and 200 matched advanced cancer inpatients referred to PC services ("inpatients") from January 1, 2010, through December 31, 2011. The median age for all patients was 56 years (range, 48-64 years); 222 (56 %) patients were female, and 243 (61 %) were white. There were no significant demographic differences between the EC patients and inpatients. The median time from admission to PC was 12 h (range, 7-23 h) for the EC patients and 24 h (24-96 h) for the inpatients (p < 0.0001). For EC patients and inpatients, symptoms at presentation for PC consultation included uncontrolled pain (83 and 45 %, respectively; p < 0.0001), nausea/vomiting/constipation (41 and 19 %, respectively; p < 0.0001), and dyspnea (29 and 19 %, respectively; p = 0.02). The medians and interquartile ranges of baseline symptom intensities for EC patients and inpatients, respectively, were as follows: pain, 7 (5-9) and 5 (2-8) (p < 0.0001); fatigue, 7 (4-8) and 6 (4-8) (p = 0.0517); and sleep, 6 (0-8) and 4 (1-7) (p = 0.1064). At follow-up, improvement was observed in pain (125/238 [53 %]), sleep (59/131 [45 %]), well-being (32/82 [39 %]), fatigue (53/139 [38 %]), anxiety (51/132 [39 %]), appetite (46/132 [35 %]), dyspnea (49/160 [31 %]), nausea (52/170 [31 %]), depression (36/123 [29 %]), and drowsiness (37/126 [29 %]). After PC consultations, discharge/admission destinations for EC patients were as follows: home, 65 (33 %); home hospice, 13 (7 %); inpatient hospice, 8 (4 %); regular hospital floor, 65 (33 %); and PC unit, 46 (23 %). The median duration of hospitalization was 92 h (range, 69-114) for hospitalized EC patients and 125 h (range, 108-142) for inpatients (p < 0.0001). Referral to PC from the EC led to earlier delivery of PC with subsequent earlier control of symptoms. EC patients who received PC consultations and were hospitalized had shorter hospitalizations than PC referral in the inpatient area. More research is needed to describe the impact of PC services on symptom assessment and management and on goals and plan of care in patients with advanced illness admitted to the EC.

OUTER LOOP LANDFILL CASE STUDY

EPA Science Inventory

This presentation will describe the interim data reaulting from a CRADA between USEPA and Waste Management, Inc. at the outer Loop Landfill Bioreactor research project located in Louisville, KY. Recently updated data will be presented covering landfill solids, gas being collecte...

Sandia National Laboratories: Research: Materials Science

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New research. Research Our research uses Sandia's experimental, theoretical, and computational capabilities to

Next Generation Source Measuments: CRADA partner communication sheet

EPA Science Inventory

Partnerships to Advance Next Gen. Source MeasurementsA growing number of government, academic, and industry groups are recognizing the revolution in air pollution and greenhouse gas source measurement science enabled by the rapid advances in sensors, communications, data integrat...

HFE p.C282Y gene variant is associated with varicose veins in Russian population.

PubMed

Sokolova, Ekaterina A; Shadrina, Alexandra S; Sevost'ianova, Kseniya S; Shevela, Andrey I; Soldatsky, Evgenii Yu; Seliverstov, Evgenii I; Demekhova, Marina Yu; Shonov, Oleg A; Ilyukhin, Evgenii A; Smetanina, Mariya A; Voronina, Elena N; Zolotukhin, Igor A; Filipenko, Maxim L

2016-08-01

Recently, the association of polymorphism rs1800562 (p.C282Y) in the hemochromatosis (HFE) gene with the increased risk of venous ulceration was shown. We hypothesized that HFE gene polymorphism might be involved not only in ulceration process, but also in susceptibility to primary varicose veins. We genotyped HFE p.C282Y (rs1800562) and p.H63D (rs1799945) variants in patients with primary varicose veins (n = 463) and in the control group (n = 754). In our study, p.282Y variant (rs1800562 A allele) was significantly associated with the risk of varicose veins (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02). A borderline significant reverse association of p.63D variant (rs1799945 G allele) with venous leg ulcer development was revealed in Russians (OR 0.25, 95 % CI = 0.06-1.00, P = 0.05), but not in the meta-analysis (P = 0.56). We conclude that the HFE gene polymorphism can affect the risk of developing primary varicose veins.

Association between mismatch repair gene MSH3 codons 1036 and 222 polymorphisms and sporadic prostate cancer in the Iranian population.

PubMed

Jafary, Fariba; Salehi, Mansoor; Sedghi, Maryam; Nouri, Nayereh; Jafary, Farzaneh; Sadeghi, Farzaneh; Motamedi, Shima; Talebi, Maede

2012-01-01

The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.

Simultaneous determination of built-in voltage and charge carrier mobility in organic diodes from light intensity dependent current-voltage characteristics

NASA Astrophysics Data System (ADS)

Huang, Fobao; Peng, Yingquan; Xu, Kun; Lv, Wenli; Xu, Sunan; Wang, Ying; Tang, Ying; Wei, Yi; Yang, Yuhuan; Liu, Guohan

2017-05-01

Built-in voltage (V bi) and charge carrier mobility are essential parameters of organic diodes, such as organic photodiodes, organic light-emitting diodes and organic solar cells. The existing methods for charge carrier mobility measurement require either expensive equipment, or stringent sample preparation. We demonstrate a method that simultaneously determines the V bi and charge carrier mobility in organic photodiodes and solar cells from incident light intensity dependent current-voltage characteristics. The V bi is determined from the saturation open-circuit voltage, while the charge carrier mobility from the space-charge limited photocurrent. The V bi for organic diodes, ‘ITO/copper phthalocyanine (CuPc)/2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline (BCP)/Al’, ‘ITO/ lead phthalocyanine (PbPc)/BCP/Al’, ‘ITO/CuPc/C60/BCP/Al’, and ‘ITO/PbPc/C60/BCP/Al’, were measured to be 0.583  ±  0.019, 0.458  ±  0.002, 0.605  ±  0.009 and 0.538  ±  0.004 V, respectively; the hole mobility of CuPc and PbPc thin films were measured to be (1.383  ±  0.367)  ×  10-6 cm2 V-1 s-1 and (3.675  ±  0.887)  ×  10-6 cm2 V-1 s-1, respectively. The measured values for V bi and carrier mobility coincide with related experimental results reported in other literature.

Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.

PubMed

Demidyuk, Ilya V; Shubin, Andrey V; Gasanov, Eugene V; Kurinov, Alexander M; Demkin, Vladimir V; Vinogradova, Tatyana V; Zinovyeva, Marina V; Sass, Alexander V; Zborovskaya, Irina B; Kostrov, Sergey V

2013-01-01

Proprotein convertases (PCs) is a protein family which includes nine highly specific subtilisin-like serine endopeptidases in mammals. The system of PCs is involved in carcinogenesis and levels of PC mRNAs alter in cancer, which suggests expression status of PCs as a possible marker for cancer typing and prognosis. The goal of this work was to assess the information value of expression profiling of PC genes. Quantitative polymerase chain reaction was used for the first time to analyze mRNA levels of all PC genes as well as matrix metalloproteinase genes MMP2 and MMP14, which are substrates of PCs, in 30 matched pairs of samples of human lung cancer tumor and adjacent tissues without pathology. Significant changes in the expression of PCs have been revealed in tumor tissues: increased FURIN mRNA level (p<0.00005) and decreased mRNA levels of PCSK2 (p<0.007), PCSK5 (p<0.0002), PCSK7 (p<0.002), PCSK9 (p<0.00008), and MBTPS1 (p<0.00004) as well as a tendency to increase in the level of PCSK1 mRNA. Four distinct groups of samples have been identified by cluster analysis of the expression patterns of PC genes in tumor vs. normal tissue. Three of these groups covering 80% of samples feature a strong elevation in the expression of a single gene in cancer: FURIN, PCSK1, or PCSK6. Thus, the changes in the expression of PC genes have a limited number of scenarios, which may reflect different pathways of tumor development and cryptic features of tumors. This finding allows to consider the mRNAs of PC genes as potentially important tumor markers.

Centralized Cryptographic Key Management and Critical Risk Assessment - CRADA Final Report For CRADA Number NFE-11-03562

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abercrombie, R. K.; Peters, Scott

The Department of Energy Office of Electricity Delivery and Energy Reliability (DOE-OE) Cyber Security for Energy Delivery Systems (CSEDS) industry led program (DE-FOA-0000359) entitled "Innovation for Increasing Cyber Security for Energy Delivery Systems (12CSEDS)," awarded a contract to Sypris Electronics LLC to develop a Cryptographic Key Management System for the smart grid (Scalable Key Management Solutions for Critical Infrastructure Protection). Oak Ridge National Laboratory (ORNL) and Sypris Electronics, LLC as a result of that award entered into a CRADA (NFE-11-03562) between ORNL and Sypris Electronics, LLC. ORNL provided its Cyber Security Econometrics System (CSES) as a tool to be modifiedmore » and used as a metric to address risks and vulnerabilities in the management of cryptographic keys within the Advanced Metering Infrastructure (AMI) domain of the electric sector. ORNL concentrated our analysis on the AMI domain of which the National Electric Sector Cyber security Organization Resource (NESCOR) Working Group 1 (WG1) has documented 29 failure scenarios. The computational infrastructure of this metric involves system stakeholders, security requirements, system components and security threats. To compute this metric, we estimated the stakes that each stakeholder associates with each security requirement, as well as stochastic matrices that represent the probability of a threat to cause a component failure and the probability of a component failure to cause a security requirement violation. We applied this model to estimate the security of the AMI, by leveraging the recently established National Institute of Standards and Technology Interagency Report (NISTIR) 7628 guidelines for smart grid security and the International Electrotechnical Commission (IEC) 63351, Part 9 to identify the life cycle for cryptographic key management, resulting in a vector that assigned to each stakeholder an estimate of their average loss in terms of dollars per day of system operation. To further address probabilities of threats, information security analysis can be performed using game theory implemented in dynamic Agent Based Game Theoretic (ABGT) simulations. Such simulations can be verified with the results from game theory analysis and further used to explore larger scale, real world scenarios involving multiple attackers, defenders, and information assets. The strategy for the game was developed by analyzing five electric sector representative failure scenarios contained in the AMI functional domain from NESCOR WG1. From these five selected scenarios, we characterized them into three specific threat categories affecting confidentiality, integrity and availability (CIA). The analysis using our ABGT simulation demonstrated how to model the AMI functional domain using a set of rationalized game theoretic rules decomposed from the failure scenarios in terms of how those scenarios might impact the AMI network with respect to CIA.« less

Finite element analysis of constrained total Condylar Knee Prosthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-07-13

Exactech, Inc., is a prosthetic joint manufacturer based in Gainesville, FL. The company set the goal of developing a highly effective prosthetic articulation, based on scientific principles, not trial and error. They developed an evolutionary design for a total knee arthroplasty system that promised improved performance. They performed static load tests in the laboratory with similar previous designs, but dynamic laboratory testing was both difficult to perform and prohibitively expensive for a small business to undertake. Laboratory testing also cannot measure stress levels in the interior of the prosthesis where failures are known to initiate. To fully optimize their designsmore » for knee arthroplasty revisions, they needed range-of-motion stress/strain data at interior as well as exterior locations within the prosthesis. LLNL developed computer software (especially NIKE3D) specifically designed to perform stress/strain computations (finite element analysis) for complex geometries in large displacement/large deformation conditions. Additionally, LLNL had developed a high fidelity knee model for other analytical purposes. The analysis desired by Exactech could readily be performed using NIKE3D and a modified version of the high fidelity knee that contained the geometry of the condylar knee components. The LLNL high fidelity knee model was a finite element computer model which would not be transferred to Exactech during the course of this CRADA effort. The previously performed laboratory studies by Exactech were beneficial to LLNL in verifying the analytical capabilities of NIKE3D for human anatomical modeling. This, in turn, gave LLNL further entree to perform work-for-others in the prosthetics field. There were two purposes to the CRADA (1) To modify the LLNL High Fidelity Knee Model to accept the geometry of the Exactech Total Knee; and (2) To perform parametric studies of the possible design options in appropriate ranges of motion so that an optimum design could be selected for production. Because of unanticipated delays in the CRADA funding, the knee design had to be finalized before the analysis could be accomplished. Thus, the scope of work was modified by the industrial partner. It was decided that it would be most beneficial to perform FEA that would closely replicate the lab tests that had been done as the basis of the design. Exactech was responsible for transmitting the component geometries to Livermore, as well as providing complete data from the quasi-static laboratory loading tests that were performed on various designs. LLNL was responsible for defining the basic finite element mesh and carrying out the analysis. We performed the initial computer simulation and verified model integrity, using the laboratory data. After performing the parametric studies, the results were reviewed with Exactech. Also, the results were presented at the Orthopedic Research Society meeting in a poster session.« less

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.

PubMed

Burnett, Lisa C; LeDuc, Charles A; Sulsona, Carlos R; Paull, Daniel; Rausch, Richard; Eddiry, Sanaa; Carli, Jayne F Martin; Morabito, Michael V; Skowronski, Alicja A; Hubner, Gabriela; Zimmer, Matthew; Wang, Liheng; Day, Robert; Levy, Brynn; Fennoy, Ilene; Dubern, Beatrice; Poitou, Christine; Clement, Karine; Butler, Merlin G; Rosenbaum, Michael; Salles, Jean Pierre; Tauber, Maithe; Driscoll, Daniel J; Egli, Dieter; Leibel, Rudolph L

2017-01-03

Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the noncoding RNA gene SNORD116. Here, we found that protein and transcript levels of nescient helix loop helix 2 (NHLH2) and the prohormone convertase PC1 (encoded by PCSK1) were reduced in PWS patient induced pluripotent stem cell-derived (iPSC-derived) neurons. Moreover, Nhlh2 and Pcsk1 expression were reduced in hypothalami of fasted Snord116 paternal knockout (Snord116p-/m+) mice. Hypothalamic Agrp and Npy remained elevated following refeeding in association with relative hyperphagia in Snord116p-/m+ mice. Nhlh2-deficient mice display growth deficiencies as adolescents and hypogonadism, hyperphagia, and obesity as adults. Nhlh2 has also been shown to promote Pcsk1 expression. Humans and mice deficient in PC1 display hyperphagic obesity, hypogonadism, decreased GH, and hypoinsulinemic diabetes due to impaired prohormone processing. Here, we found that Snord116p-/m+ mice displayed in vivo functional defects in prohormone processing of proinsulin, pro-GH-releasing hormone, and proghrelin in association with reductions in islet, hypothalamic, and stomach PC1 content. Our findings suggest that the major neuroendocrine features of PWS are due to PC1 deficiency.

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome

PubMed Central

Burnett, Lisa C.; LeDuc, Charles A.; Sulsona, Carlos R.; Paull, Daniel; Rausch, Richard; Eddiry, Sanaa; Carli, Jayne F. Martin; Morabito, Michael V.; Skowronski, Alicja A.; Hubner, Gabriela; Zimmer, Matthew; Wang, Liheng; Day, Robert; Levy, Brynn; Dubern, Beatrice; Poitou, Christine; Clement, Karine; Rosenbaum, Michael; Salles, Jean Pierre; Tauber, Maithe; Egli, Dieter

2016-01-01

Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the noncoding RNA gene SNORD116. Here, we found that protein and transcript levels of nescient helix loop helix 2 (NHLH2) and the prohormone convertase PC1 (encoded by PCSK1) were reduced in PWS patient induced pluripotent stem cell–derived (iPSC-derived) neurons. Moreover, Nhlh2 and Pcsk1 expression were reduced in hypothalami of fasted Snord116 paternal knockout (Snord116p–/m+) mice. Hypothalamic Agrp and Npy remained elevated following refeeding in association with relative hyperphagia in Snord116p–/m+ mice. Nhlh2-deficient mice display growth deficiencies as adolescents and hypogonadism, hyperphagia, and obesity as adults. Nhlh2 has also been shown to promote Pcsk1 expression. Humans and mice deficient in PC1 display hyperphagic obesity, hypogonadism, decreased GH, and hypoinsulinemic diabetes due to impaired prohormone processing. Here, we found that Snord116p–/m+ mice displayed in vivo functional defects in prohormone processing of proinsulin, pro-GH–releasing hormone, and proghrelin in association with reductions in islet, hypothalamic, and stomach PC1 content. Our findings suggest that the major neuroendocrine features of PWS are due to PC1 deficiency. PMID:27941249

The influence of magnetic fields exposure on neurite outgrowth in PC12 rat pheochromocytoma cells

NASA Astrophysics Data System (ADS)

Fan, W.; Ding, J.; Duan, W.; Zhu, Y. M.

2004-11-01

The aim of present work was to investigate the influence of magnetic fields exposure on neurite outgrowth in PC12 cells. The neurite number per cell, length of neurites and directions of neurite growth with respect to the direction of the magnetic field were analyzed after exposure to 50 Hz electromagnetic field for 96 h. A promotion was observed under a weak field (0.23 mT), as the average number of neurites per cell increased to 2.38±0.06 compared to 1.91±0.07 neurites/cell of the control dishes, while inhibition and directional outgrowth was evident under a relatively stronger field (1.32 mT). Our work shows that biological systems can be very sensitive to the strength of electromagnetic field.

GREEN REACTION CHEMISTRIES PERFORMED IN THE SPINNING TUBE-IN-TUBE (STT) REACTOR

EPA Science Inventory

The U. S. Environmental Protection Agency (USEPA) and Kreido Laboratories have established a Cooperative Research and Development Agreement (CRADA) collaboration, to develop and commercialize green and sustainable chemistries in the area of industrial chemical synthesis. Utilizi...

Sandia National Laboratories: Sandia National Laboratories: Missions:

Science.gov Websites

Transfer Browse Technology Portfolios Technology Partnerships Business, Industry, & Non-Profits Agreements Cooperative Research and Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal atmospheric flight with emphasis on aerodynamics; navigation, guidance and control; and thermal protection

Sandia National Laboratories: Contact Us

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New )* Non-mail deliveries: 1515 Eubank SE Albuquerque, NM 87123 Sandia National Laboratories, California P.O

Sandia National Laboratories: Predicting Performance Margins

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New areas of Materials Sciences, leveraging both experimental and modeling expertise at Sandia. The PPM

Sandia National Laboratories: Research: Research Foundations: Engineering

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New engineering transitions in advanced, highly critical systems by integrating theory development, experimental

Sandia National Laboratories: Careers: Materials Science

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New Sandia's experimental, theoretical, and computational capabilities to establish the state of the art in

Direct sp(3)C-H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis.

PubMed

Feng, Zhu-Jia; Xuan, Jun; Xia, Xu-Dong; Ding, Wei; Guo, Wei; Chen, Jia-Rong; Zou, You-Quan; Lu, Liang-Qiu; Xiao, Wen-Jing

2014-04-07

Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp(3) C-H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50-91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er).

A Systematic Examination of the Association between Parental and Child Obesity across Countries123

PubMed Central

Wang, Youfa; Min, Jungwon; Khuri, Jacob; Li, Miao

2017-01-01

Childhood obesity has become a global epidemic. Parents can have an important influence on their children’s health behaviors and weight status. Many studies have examined the association between parental and childhood weight status. However, much heterogeneity between studies exists, and the parent-child (P-C) association in obesity has varied. The purpose of this systematic examination and meta-analysis was to examine the strength and variation of the P-C association in obesity and to identify factors (e.g., demographic characteristics and country’s economic level) that may influence this association. PubMed was searched for relevant studies published between January 2000 and July 2015. Thirty-two studies from 21 countries met inclusion criteria; 27 reported ORs for the P-C obesity association and were included in a meta-analysis. The meta-analysis showed a strong P-C obesity association (pooled OR: 2.22; 95% CI: 2.09, 2.36), which varied by type of P-C pair (i.e., parents-child, father-child, and mother-child), child age, parent and child weight status, and the country’s economic level. Stronger associations were shown in older children than in younger children (β ± SE: 0.02 ± 0.01), in both parents than in father only (β ± SE: 0.51 ± 0.11) or mother only (β ± SE: 0.38 ± 0.11), in parental obesity (β ± SE: 0.26 ± 0.10) and child obesity (β ± SE: 0.28 ± 0.12) than in parental and child overweight, and in high- than in middle-income countries (β ± SE: 0.23 ± 0.08). Thus, research from multiple countries shows significant P-C associations in weight status, but this association varies by child age, type of P-C pair, weight status, and the country’s economic level. Results suggest that families and parents should be a key target for obesity intervention efforts. PMID:28507009

A Systematic Examination of the Association between Parental and Child Obesity across Countries.

PubMed

Wang, Youfa; Min, Jungwon; Khuri, Jacob; Li, Miao

2017-05-01

Childhood obesity has become a global epidemic. Parents can have an important influence on their children's health behaviors and weight status. Many studies have examined the association between parental and childhood weight status. However, much heterogeneity between studies exists, and the parent-child (P-C) association in obesity has varied. The purpose of this systematic examination and meta-analysis was to examine the strength and variation of the P-C association in obesity and to identify factors (e.g., demographic characteristics and country's economic level) that may influence this association. PubMed was searched for relevant studies published between January 2000 and July 2015. Thirty-two studies from 21 countries met inclusion criteria; 27 reported ORs for the P-C obesity association and were included in a meta-analysis. The meta-analysis showed a strong P-C obesity association (pooled OR: 2.22; 95% CI: 2.09, 2.36), which varied by type of P-C pair (i.e., parents-child, father-child, and mother-child), child age, parent and child weight status, and the country's economic level. Stronger associations were shown in older children than in younger children (β ± SE: 0.02 ± 0.01), in both parents than in father only (β ± SE: 0.51 ± 0.11) or mother only (β ± SE: 0.38 ± 0.11), in parental obesity (β ± SE: 0.26 ± 0.10) and child obesity (β ± SE: 0.28 ± 0.12) than in parental and child overweight, and in high- than in middle-income countries (β ± SE: 0.23 ± 0.08). Thus, research from multiple countries shows significant P-C associations in weight status, but this association varies by child age, type of P-C pair, weight status, and the country's economic level. Results suggest that families and parents should be a key target for obesity intervention efforts. © 2017 American Society for Nutrition.

Internet search query analysis can be used to demonstrate the rapidly increasing public awareness of palliative care in the USA.

PubMed

McLean, Sarah; Lennon, Paul; Glare, Paul

2017-01-27

A lack of public awareness of palliative care (PC) has been identified as one of the main barriers to appropriate PC access. Internet search query analysis is a novel methodology, which has been effectively used in surveillance of infectious diseases, and can be used to monitor public awareness of health-related topics. We aimed to demonstrate the utility of internet search query analysis to evaluate changes in public awareness of PC in the USA between 2005 and 2015. Google Trends provides a referenced score for the popularity of a search term, for defined regions over defined time periods. The popularity of the search term 'palliative care' was measured monthly between 1/1/2005 and 31/12/2015 in the USA and in the UK. Results were analysed using independent t-tests and joinpoint analysis. The mean monthly popularity of the search term increased between 2008-2009 (p<0.001), 2011-2012 (p<0.001), 2013-2014 (p=0.004) and 2014-2015 (p=0.002) in the USA. Joinpoint analysis was used to evaluate the monthly percentage change (MPC) in the popularity of the search term. In the USA, the MPC increase was 0.6%/month (p<0.05); in the UK the MPC of 0.05% was non-significant. Although internet search query surveillance is a novel methodology, it is freely accessible and has significant potential to monitor health-seeking behaviour among the public. PC is rapidly growing in the USA, and the rapidly increasing public awareness of PC as demonstrated in this study, in comparison with the UK, where PC is relatively well established is encouraging in increasingly ensuring appropriate PC access for all. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

[Knowledge about Biosimilars in Primary Care: a study by the Spanish Society of Primary Care Physicians (SEMERGEN)].

PubMed

Micó-Pérez, R M; Payares-Herrera, C; Palomo-Jiménez, P I; Sánchez-Fierro, J; Avendaño-Solá, C; Llisterri-Caro, J L

2018-02-16

The objective of this study was to evaluate the awareness and training needs on biosimilar drugs in Primary Care (PC) physicians. Descriptive cross-sectional study based on an on-line questionnaire with a total of 34 multiple choice questions, published on the SEMERGEN website. The main Knowledge areas were: biosimilar definition; regulatory and legal framework; prescription, traceability, interchangeability and pharmacovigilance; availability of biosimilars in the PC setting, and the biosimilars contribution to sustainability. The software used for the analysis and data processing was the Barbwin 7.5. An analysis was performed on the responses from 701 questionnaires completed. There was a slight majority (57%) of women participants. The majority of participant worked in urban centres (60.91%). The definition of biosimilar was not known by 58% of those that responded, and 73% were unaware that the management of biosimilars and generics was not comparable. Most (84%) of those that responded were not aware that the studies required for the approval of biosimilars is different from reference biological medicines. Around two-thirds (66%) those that responded did not know of any biosimilars available in PC setting, and the 94% were also unaware of the Spanish legal framework for the management of biosimilar medicines. The current knowledge about biosimilars among PC physicians is low. The critical areas in need of further training include specific information on biosimilars currently available in PC setting, as well as key aspects regarding prescription, interchangeability and pharmacovigilance requirements. Six out of ten doctors do not know of any biosimilar used in PC in Spain. Copyright © 2018 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

[Toxicity of Pythium oligandrum broth to animal and its control effect on rot diseases caused by Penicillium italicum and Penicillium digitatum in orange fruit storage].

PubMed

Tan, Yan; Peng, Liangzhi; Yuan, Ling; Wang, Shaobo

2015-11-04

In order to develop a safe, nontoxic and efficient biological antistaling agent and to decrease the incidence of rot diseases caused by the Penicillium italicum and Penicillium digitatum in orange fruit storage. the present experiment was carried out with Pythium oligandrum broth (POB) produced by our self-isolated strain (P. oligandrum CQ2010) to study the toxicity to animal. Thereafter, mycelium growth and spore germination of both P. digitatum and P. italicum and control effect of rot disease in orange storage were compared after treated by liquid culture medium (control), POB, prochloraz (PC) , and PC + POB. Gastric lavage with large amount POB did not influence mouse weight. The animals also showed no abnormality in appearance, behaviors and pathology changes in heart, liver, kidney, lung and intestine. POB decreased the hyphal growth by 70.24% - 93.74% and spore germination by 44.91% - 87.82% (24 h after POB addition) of these two pathogenic fungi. Disease incidence of orange fruit following P. italicum inoculation changed in the sequence: CK > POB > PC > PC + POB and the control efficacy behaved otherwise. In commercial simulation storage, the disease incidence of orange fruit caused by P. digitatum and P. italicum was above 50% of the total. The fruit rot rate was 26.40% (CK), 15.03% (POB), 16.61% (PC) and 4.21% (PC + POB). There were no significant differences in fruit quality under different treatments. POB was safe to animal and could decrease rot disease incidence caused by P. italicum and P. digitatum in orange storage whereby producing a positive interaction with prochloraz and controlling rot diseases caused by these two fungi.

Neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1, and carbohydrate antigen 19-9 in pancreatic juice: pathobiologic implications in diagnosing benign and malignant disease of the pancreas.

PubMed

Kaur, Sukhwinder; Baine, Michael J; Guha, Sushovan; Ochi, Nobuo; Chakraborty, Subhankar; Mallya, Kavita; Thomas, Colleen; Crook, Julia; Wallace, Michael B; Woodward, Timothy A; Jain, Maneesh; Singh, Shailender; Sasson, Aaron R; Skinner, Verna; Raimondo, Massimo; Batra, Surinder K

2013-04-01

Pancreatic diseases pose significant diagnostic challenge as signs and symptoms often overlap. We investigated the potential of pancreatic juice neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1 (MIC-1), and carbohydrate antigen 19-9 (CA19-9) to aid in the diagnosis of patients with symptoms suggestive of pancreatic diseases. A total of 105 chronic pancreatitis (CP), pancreatic cancer (PC), and nonpancreatic nonhealthy (patients with symptoms mimicking pancreatic disease but found to be free of any pancreatic disease) patients underwent endoscopic pancreatic juice collection after secretin stimulation. Neutrophil gelatinase-associated lipocalin and MIC-1 levels were measured by enzyme-linked immunosorbent assay, whereas CA19-9 was measured by radioimmunoassay. Neutrophil gelatinase-associated lipocalin, MIC-1, and CA19-9 were significantly elevated in the pancreatic juice of patients with CP and patients with PC as compared with nonpancreatic nonhealthy controls (P ≤ 0.034). Neutrophil gelatinase-associated lipocalin seemed most promising in differentiating diseased versus nondiseased pancreata (areas under the curve, 0.88-0.91), whereas MIC-1 was found to be higher in patients with PC than in patients with CP (P = 0.043). Interestingly, MIC-1 levels in diabetic patients with PC were higher than in nondiabetic patients with PC (P = 0.030) and diabetic patients with CP (P = 0.087). Carbohydrate antigen 19-9 showed the least ability to distinguish patient groups (areas under the curve, 0.61-0.76). Pancreatic juice neutrophil gelatinase-associated lipocalin shows potential utility in establishing pancreatic etiology in the context of nonspecific symptoms, whereas MIC-1 may aid in differentiating PC from CP.

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction

PubMed Central

Hayee, Bu'Hussain; Antonopoulos, Aristotelis; Murphy, Emma J; Rahman, Farooq Z; Sewell, Gavin; Smith, Bradley N; McCartney, Sara; Furman, Mark; Hall, Georgina; Bloom, Stuart L; Haslam, Stuart M; Morris, Howard R; Boztug, Kaan; Klein, Christoph; Winchester, Bryan; Pick, Edgar; Linch, David C; Gale, Rosemary E; Smith, Andrew M; Dell, Anne; Segal, Anthony W

2011-01-01

Glucose-6-phosphatase, an enzyme localized in the endoplasmic reticulum (ER), catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate. In humans, there are three differentially expressed glucose-6-phosphatase catabolic genes (G6PC1–3). Recently, it has been shown that mutations in the G6PC3 gene result in a syndrome associating congenital neutropenia and various organ malformations. The enzymatic function of G6PC3 is dependent on G6P transport into the ER, mediated by G6P translocase (G6PT). Mutations in the gene encoding G6PT result in glycogen storage disease type-1b (GSD-1b). Interestingly, GSD-1b patients exhibit a similar neutrophil dysfunction to that observed in G6PC3-deficient patients. To better understand the causes of neutrophil dysfunction in both diseases, we have studied the neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of patients with G6PC3 and G6PT syndromes. Unexpectedly, sodium dodecyl sulfate–polyacrylamide gel electrophoresis experiments indicated hypo-glycosylation of gp91phox, the electron-transporting component of the NADPH oxidase, in all of these patients. Rigorous mass spectrometric glycomic profiling showed that most of the complex-type antennae which characterize the neutrophil N-glycome of healthy individuals were severely truncated in the patients' neutrophils. A comparable truncation of the core 2 antenna of the O-glycans was also observed. This aberrant neutrophil glycosylation is predicted to have profound effects on the neutrophil function and merit designation of both syndromes as a new class of congenital disorders of glycosylation. PMID:21385794

Agreement between central corneal thickness measured using Pentacam, ultrasound pachymetry, specular microscopy and optic biometer Lenstar LS 900 and the influence of intraocular pressure.

PubMed

Borrego-Sanz, L; Sáenz-Francés, F; Bermudez-Vallecilla, M; Morales-Fernández, L; Martínez-de-la-Casa, J M; Santos-Bueso, E; Jañez, L; García-Feijoo, J

2014-01-01

To compare central corneal thickness (CCT) values obtained by Lenstar (LE), Pentacam (PC), specular microscopy (SM) and ultrasound pachymetry (UP) in healthy corneas and study their influence on intraocular pressure (IOP) readings determined by Goldmann applanation tonometry (GAT). CCT was measured in 76 healthy subjects by LE, PC, SM and UP. We established Lin's concordance correlation coefficient (ρ-C) between different techniques. The influence of CCT on GAT was established through univariate linear regression models, IOP being the dependent variable. The highest ρ-C was found between LE and SM at 0.94 (95% CI: 0.91-0.96) and between LE and UP at 0.95 (95% CI: 0.94-0.97). IOP readings showed less variability when CCT was determined using LE (7.7%, B = 0.16; 95% CI: 0.004-0.28). Although CCT values obtained with UP, PC, SM and LE show good correlation, these methods are not completely interchangeable. The amount of IOP variation differs when CCT is determined using LE or SM. © 2014 S. Karger AG, Basel.

Sandia National Laboratories: Strategic Partnership Projects, Non-Federal

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New Sandia Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements Alt text Potential

Climbing The Knowledge Mountain - The New Solids Processing Design And Management Manual (Presentation)

EPA Science Inventory

The USEPA, Water Environment Federation (WEF) and Water Environment Research Foundation (WERF), under a Cooperative Research and Development Agreement (CRADA), are undertaking a massive effort to produce a Solids Processing Design and Management Manual (Manual). The Manual, repr...

Climbing The Knowledge Mountain - The New Solids Processing Design And Management Manual

EPA Science Inventory

The USEPA, Water Environment Federation (WEF) and Water Environment Research Foundation (WERF), under a Cooperative Research and Development Agreement (CRADA), are undertaking a massive effort to produce a Solids Processing Design and Management Manual (Manual). The Manual, repr...

PROCESS INTENSIFIED GREEN REACTION CHEMISTRIES PERFORMED IN THE SPINNING TUBE-IN-TUBE (STT®) REACTOR

EPA Science Inventory

The U. S. Environmental Protection Agency (USEPA) and Kreido Laboratories have established a Cooperative Research and Development Agreement (CRADA) collaboration, to develop and commercialize green and sustainable chemistries in the area of industrial chemical synthesis. Utilizi...

LEACHATE NITROGEN CONCENTRATIONS AND BACTERIAL NUMBERS FROM TWO BIOREACTOR LANDFILLS

EPA Science Inventory

The U.S. EPA and Waste Management Inc. have entered into a cooperative research and development agreement (CRADA) to study landfills operated as bioreactors. Two different landfill bioreactor configurations are currently being tested at the Outer Loop landfill in Louisville, KY...

Sandia National Laboratories: National Security Missions: Defense Systems

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New leadership for the national security community by delivering cutting-edge experimental and operational sensor

Sandia National Laboratories: National Security Missions: Nuclear Weapons

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New , in which fundamental science, computer models, and unique experimental facilities come together so

Nondestructive x-ray Scattering Characterization of High Temperature Superconducting Wires

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thurston, T R

The purpose of this CRADA was to characterize the structural properties of the superconductor material within the wires in order to determine which processing procedures produce the best superconductor texture and phase development, and hence the best ultimate current carrying capacity.

21 CFR 516.141 - Qualified expert panels.

Code of Federal Regulations, 2012 CFR

2012-04-01

... funding from the requestor through a contract or research grant (either directly or indirectly through...), including for each the following: Name of the firm, topic/issue, amount received, date initiated. (iv) Contracts, grants, Cooperation Research and Development Agreement (CRADAs) (current or under negotiation...

21 CFR 516.141 - Qualified expert panels.

Code of Federal Regulations, 2013 CFR

2013-04-01

... funding from the requestor through a contract or research grant (either directly or indirectly through...), including for each the following: Name of the firm, topic/issue, amount received, date initiated. (iv) Contracts, grants, Cooperation Research and Development Agreement (CRADAs) (current or under negotiation...

21 CFR 516.141 - Qualified expert panels.

Code of Federal Regulations, 2014 CFR

2014-04-01

... funding from the requestor through a contract or research grant (either directly or indirectly through...), including for each the following: Name of the firm, topic/issue, amount received, date initiated. (iv) Contracts, grants, Cooperation Research and Development Agreement (CRADAs) (current or under negotiation...

78 FR 57401 - Cooperative Research and Development Agreement (CRADA) Opportunity With the Department of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-18

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2013-0064] Cooperative Research and Development... Research of Purpose Bred Explosive Detection Canines AGENCY: Science and Technology Directorate... canines; understanding, collection and analysis of quantitative behavior trait measurement; application of...

Automatic control of a negative ion source

NASA Astrophysics Data System (ADS)

Saadatmand, K.; Sredniawski, J.; Solensten, L.

1989-04-01

A CAMAC based control architecture is devised for a Berkeley-type H - volume ion source [1]. The architecture employs three 80386 TM PCs. One PC is dedicated to control and monitoring of source operation. The other PC functions with digitizers to provide data acquisition of waveforms. The third PC is used for off-line analysis. Initially, operation of the source was put under remote computer control (supervisory). This was followed by development of an automated startup procedure. Finally, a study of the physics of operation is now underway to establish a data base from which automatic beam optimization can be derived.

KSC-98pc542

NASA Image and Video Library

1998-04-28

The SPACEHAB Single Module is raised by crane from a transporter in KSC's Space Station Processing Facility, where it will be moved to the payload canister. It will be joined in the canister by the Alpha Magnetic Spectrometer-01 payload before being moved to Launch Pad 39A for the STS-91 mission, scheduled to launch June 2 at around 6:04 p.m. EDT. SPACEHAB is used mainly as a large pressurized cargo container for science, logistical equipment and supplies to be exchanged between the orbiter Discovery and the Russian Space Station Mir. The nearly 10-day flight of STS-91 also is scheduled to return the sixth American, Mission Specialist Andrew Thomas, Ph.D., aboard the Russian orbiting outpost safely to Earth

Interferon-gamma +874 T/A and interleukin-10 -1082 A/G single nucleotide polymorphism in Egyptian children with tuberculosis.

PubMed

Mosaad, Y M; Soliman, O E; Tawhid, Z E; Sherif, D M

2010-10-01

The aim was to investigate the association of interferon-gamma (IFN-γ) +874 T/A and interleukin-10 (IL-10)-1082 A/G single nucleotide polymorphisms with tuberculous infection and post-BCG lymphadenitis in Egyptian children. IFN-γ +874 T/A and IL-10 -1082 A/G polymorphism detection by amplification refractory mutation system technique was carried out for 110 patients with TB, 40 patients with post-BCG lymphadenitis and 118 healthy controls. IFN-γ +874 A allele was higher in TB and post-BCG patients than those in healthy controls (Pc=0.006 and 0.002, respectively). IFN-γ +874 genotype AA was significantly higher in patients with TB than that in control (Pc=0.015), in extrapulmonary than patients with pulmonary TB (PTB) (Pc=0.009), and young children with TB below 5 years (Pc=0.024). No statistically significant differences were observed between patients with TB and controls for the frequency of IL-10(-1082) alleles or genotypes (P>0.05); however, a statistically significant difference in the frequency of IL-10 (-1082) GG genotype was found between patients with pulmonary and extrapulmonary TB (Pc=0.003). Low producer IFN-γ +874 A/A genotype is associated with post-BCG lymphadenitis and TB disease especially in younger children below 5 years. IL-10-1082 G/G genotype did not exhibit significant association except for increased GG frequency in PTB. Both cytokine polymorphisms have no relation to tuberculin reaction in patients with TB. © 2010 The Authors. Scandinavian Journal of Immunology © 2010 Blackwell Publishing Ltd.

Polycystin-2-dependent control of cardiomyocyte autophagy.

PubMed

Criollo, Alfredo; Altamirano, Francisco; Pedrozo, Zully; Schiattarella, Gabriele G; Li, Dan L; Rivera-Mejías, Pablo; Sotomayor-Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K; Jiang, Nan; May, Herman I; Morselli, Eugenia; Somlo, Stefan; de Smedt, Humbert; Gillette, Thomas G; Lavandero, Sergio; Hill, Joseph A

2018-05-01

Considerable evidence points to critical roles of intracellular Ca 2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) encoding polycystin-2 (PC2) are associated with autosomal dominant polycystic kidney disease (ADPKD), the most common inherited nephropathy. PC2 has been associated with impaired Ca 2+ handling in cardiomyocytes and indirect evidence suggests that this protein may be involved in autophagic control. Here, we investigated the role for PC2 as an essential regulator of Ca 2+ homeostasis and autophagy. Activation of autophagic flux triggered by mTOR inhibition either pharmacologically (rapamycin) or by means of nutrient depletion was suppressed in cells depleted of PC2. Moreover, cardiomyocyte-specific PC2 knockout mice (αMhc-cre;Pkd2 F/F mice) manifested impaired autophagic flux in the setting of nutrient deprivation. Stress-induced autophagy was blunted by intracellular Ca 2+ chelation using BAPTA-AM, whereas removal of extracellular Ca 2+ had no effect, pointing to a role of intracellular Ca 2+ homeostasis in stress-induced cardiomyocyte autophagy. To determine the link between stress-induced autophagy and PC2-induced Ca 2+ mobilization, we over-expressed either wild-type PC2 (WT) or a Ca 2+ -channel deficient PC2 mutant (PC2-D509V). PC2 over-expression increased autophagic flux, whereas PC2-D509V expression did not. Importantly, autophagy induction triggered by PC2 over-expression was attenuated by BAPTA-AM, supporting a model of PC2-dependent control of autophagy through intracellular Ca 2+ . Furthermore, PC2 ablation was associated with impaired Ca 2+ handling in cardiomyocytes marked by partial depletion of sarcoplasmic reticulum Ca 2+ stores. Finally, we provide evidence that Ca 2+ -mediated autophagy elicited by PC2 is a mechanism conserved across multiple cell types. Together, this study unveils PC2 as a novel regulator of autophagy acting through control of intracellular Ca 2+ homeostasis. Copyright © 2018. Published by Elsevier Ltd.

Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY 2014 First Quarterly Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Ba Nghiep; Sanborn, Scott E.; Simmons, Kevin L.

2014-02-19

The CRADA between PNNL, Autodesk, Toyota and Magna has been effective since October 28th, 2013. The whole team including CRADA and subcontract partners kicked off the project technically on November 1st, 2013. This report describes work performed during the first quarter of FY 2014. The following technical progresses have been made toward project milestones: 1) The project kickoff meeting was organized at PlastiComp, Inc. in Winona on November 13th, 2013 involving all the project partners. During this meeting the research plan and Gantt chart were discussed and refined. The coordination of the research activities among the partners was also discussedmore » to ensure that the deliverables and timeline will be met. 2) Autodesk delivered a research version of ASMI to PNNL for process modeling using this tool under the project. PNNL installed this research version on a PNNL computer and tested it. Currently, PNNL is using ASMI to prepare the models for PlastiComp plaques. 3) PlastiComp has compounded long carbon-fiber reinforced polypropylene and polyamide 6,6 compounds for rheological and thermal characterization tests by the Autodesk laboratories in Melbourne, Australia. 4) Initial mold flow analysis was carried out by PlastiComp to confirm that the 3D complex part selected by Toyota as a representative automotive part is moldable. 5) Toyota, Magna, PlastiComp and PNNL finalized the planning for molding the Toyota 3D complex part. 6) Purdue University worked with PNNL to update and specify the test matrix for characterization of fiber length/orientation. 7) Purdue University developed tools to automate the data collection and analysis of fiber length and orientation measurements. 8) Purdue University designed and specified equipment to replace the need for equipment using the technology established by the University of Leeds at General Motors.« less

Plug-and -Play Model Architecture and Development Environment for Powertrain/Propulsion System - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rousseau, Aymeric

2013-02-01

Several tools already exist to develop detailed plant model, including GT-Power, AMESim, CarSim, and SimScape. The objective of Autonomie is not to provide a language to develop detailed models; rather, Autonomie supports the assembly and use of models from design to simulation to analysis with complete plug-and-play capabilities. Autonomie provides a plug-and-play architecture to support this ideal use of modeling and simulation for math-based automotive control system design. Models in the standard format create building blocks, which are assembled at runtime into a simulation model of a vehicle, system, subsystem, or component to simulate. All parts of the graphical usermore » interface (GUI) are designed to be flexible to support architectures, systems, components, and processes not yet envisioned. This allows the software to be molded to individual uses, so it can grow as requirements and technical knowledge expands. This flexibility also allows for implementation of legacy code, including models, controller code, processes, drive cycles, and post-processing equations. A library of useful and tested models and processes is included as part of the software package to support a full range of simulation and analysis tasks, immediately. Autonomie also includes a configuration and database management front end to facilitate the storage, versioning, and maintenance of all required files, such as the models themselves, the model’s supporting files, test data, and reports. During the duration of the CRADA, Argonne has worked closely with GM to implement and demonstrate each one of their requirements. A use case was developed by GM for every requirement and demonstrated by Argonne. Each of the new features were verified by GM experts through a series of Gate. Once all the requirements were validated they were presented to the directors as part of GM Gate process.« less

Evaluation of Subsurface Flow and Free-water Surface Wetlands Treating NPR-3 Produced Water - Year No. 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myers, J. E.; Jackson, L. M.

2001-10-13

This paper is a summary of some of the activities conducted during the first year of a three-year cooperative research and development agreement (CRADA) between the Department of Energy (DOE) Rocky Mountain Oilfield Testing Center (RMOTC) and Texaco relating to the treatment of produced water by constructed wetlands. The first year of the CRADA is for design, construction and acclimation of the wetland pilot units. The second and third years of the CRADA are for tracking performance of pilot wetlands as the plant and microbial communities mature. A treatment wetland is a proven technology for the secondary and tertiary treatmentmore » of produced water, storm water and other wastewaters. Treatment wetlands are typically classified as either free-water surface (FWS) or subsurface flow (SSF). Both FWS and SSF wetlands work well when properly designed and operated. This paper presents a collection of kinetic data gathered from pilot units fed a slipstream of Wyoming (NPR-3) produced water. The pilot units are set up outdoors to test climatic influences on treatment. Monitoring parameters include evapotranspiration, plant growth, temperature, and NPDES discharge limits. The pilot wetlands (FWS and SSF) consist of a series of 100-gal plastic tubs filled with local soils, gravel, sharp sand and native wetland plants (cattail (Typha spp.), bulrush (Scirpus spp.), dwarf spikerush (Eleocharis)). Feed pumps control hydraulic retention time (HRT) and simple water control structures control the depth of water. The treated water is returned to the existing produced water treatment system. All NPDES discharge limits are met. Observations are included on training RMOTC summer students to do environmental work.« less

Type and frequency of side effects during PC6 acupuncture: observations from therapists and patients participating in clinical efficacy trials of acupuncture.

PubMed

Enblom, Anna; Johnsson, Anna

2017-12-01

Many therapists practise PC6 acupuncture for emesis (nausea and vomiting) during pregnancy, different cancer therapies, palliative care, after surgery, or to induce relaxing effects in general. Knowledge of side effects is central to shared decision-making. To describe the type and frequency of side effects and the level of needle-induced pain during PC6 acupuncture. We included 1298 PC6 acupuncture treatments, delivered to 221 participants (77% women, mean age 52.5, range 18-91 years). The subjects had received genuine PC6 acupuncture, in one of two previous randomised controlled trials, aimed at inducing antiemetic (n=100, with 100 providing data on side effects and 94 on needle-induced pain, respectively) or relaxing (n=121, with 120 providing data) effects. Side effects during and after the acupuncture treatments were registered in structured treatment protocols and study diaries. No serious complications occurred. Side effects during the acupuncture sessions included minor bleeding in 5.0%, tiredness in 4.9%, numbness in 4.5% and dizziness in 1.4% of the 1298 treatments. After treatment, the mean proportions of participants reporting side effects each week were: tiredness 25.8%; feeling cold 17.8%; dizziness 9.7%; sweating 9.3%; haematoma 8.8%; and soreness at the needling sites 4.3%. Participants perceived the needling to be not painful (47.4% of participants), or mildly (39.1%), moderately (11.6%) or very painful (1.4%). Few side effects occurred and those that did were mild. Nearly 90% found PC6 acupuncture to be not painful or only mildly painful. Healthcare professionals may consider the observed levels of side effects when informing patients about side effects of PC6 acupuncture. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

VLBI observations of the nucleus of Centaurus A

NASA Technical Reports Server (NTRS)

Preston, R. A.; Wehrle, A. E.; Morabito, D. D.; Jauncey, D. L.; Batty, M. J.; Haynes, R. F.; Wright, A. E.; Nicolson, G. D.

1983-01-01

VLBI observations of the nucleus of Centaurus A made at 2.3 GHz on baselines with minimum fringe spacings of 0.15 and 0.0027 arcsec are presented. Results show that the nuclear component is elongated with a maximum extent of approximately 0.05 arcsec which is equivalent to a size of approximately 1 pc at the 5 Mpc distance of Centaurus A. The position angle of the nucleus is found to be 30 + or - 20 degrees, while the ratio of nuclear jet length to width is less than or approximately equal to 20. The nuclear flux density is determined to be 6.8 Jy, while no core component is found with an extent less than or approximately equal to 0.001 (less than or approximately equal to 0.02 pc) with a flux density of greater than or approximately equal to 20 mJy. A model of the Centaurus A nucleus composed of at least two components is developed on the basis of these results in conjunction with earlier VLBI and spectral data. The first component is an elongated source of approximately 0.05 arcsec (approximately 1 pc) size which contains most of the 2.3 GHz nuclear flux, while the second component is a source of approximately 0.0005 arcsec (approximately 0.01 pc) size which is nearly completely self-absorbed at 2.3 GHz but strengthens at higher frequencies.

Localized double-array stacking analysis of PcP: D″ and ULVZ structure beneath the Cocos plate, Mexico, central Pacific, and north Pacific

USGS Publications Warehouse

Hutko, Alexander R.; Lay, Thorne; Revenaugh, Justin

2009-01-01

A large, high quality P-wave data set comprising short-period and broadband signals sampling four separate regions in the lowermost mantle beneath the Cocos plate, Mexico, the central Pacific, and the north Pacific is analyzed using regional one-dimensional double-array stacking and modelling with reflectivity synthetics. A data-screening criterion retains only events with stable PcP energy in the final data stacks used for modelling and interpretation. This significantly improves the signal stacks relative to including unscreened observations, allows confident alignment on the PcP arrival and allows tight bounds to be placed on P-wave velocity structure above the core–mantle boundary (CMB). The PcP reflections under the Cocos plate are well modelled without any ultra-low velocity zone from 5 to 20°N. At latitudes from 15 to 20°N, we find evidence for two P-wave velocity discontinuities in the D″ region. The first is ∼182 km above the CMB with a δln Vp of +1.5%, near the same depth as a weaker discontinuity (<+0.5%) observed from 5 to 15°N in prior work. The other reflector is ∼454 km above the CMB, with a δln Vp of +0.4%; this appears to be a shallower continuation of the joint P- and S-wave discontinuity previously detected south of 15° N, which is presumed to be the perovskite to post-perovskite phase transition. The data stacks for paths bottoming below Mexico have PcP images that are well matched with the simple IASP91 structure, contradicting previous inferences of ULVZ presence in this region. These particular data are not very sensitive to any D″ discontinuities, and simply bound them to be <∼2%, if present. Data sampling the lowermost mantle beneath the central Pacific confirm the presence of a ∼15-km thick ultra-low velocity zone (ULVZ) just above the CMB, with δln Vp and δln Vs of around −3 to −4% and −4 to −8%, respectively. The ULVZ models predict previous S-wave data stacks well. The data for this region indicate laterally varying Vp discontinuities in D″, with one subregion having a δln Vp of 0.5% 140 km above the CMB. Beneath the north Pacific, the PcP arrivals are compatible with only weak ULVZ (δln Vp ∼ 0 to −3%), and there is a weak D″ reflector with δln Vp = 0.5%, near 314 km above the CMB. These results indicate localized occurrence of detectable ULVZ structures rather than ubiquitous ULVZ structure and emphasize the distinctiveness between the large low shear velocity province under the central Pacific and circum-Pacific regions.

Measurement of the CP-violating phase ϕs in Bs(0)→Ds(+)Ds(-) decays.

PubMed

Aaij, R; Abellán Beteta, C; Adeva, B; Adinolfi, M; Affolder, A; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Anderson, J; Andreassen, R; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baesso, C; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Borsato, M; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; Brett, D; Britsch, M; Britton, T; Brodzicka, J; Brook, N H; Brown, H; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chefdeville, M; Chen, S; Cheung, S-F; Chiapolini, N; Chrzaszcz, M; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Cogoni, V; Cojocariu, L; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Corvo, M; Counts, I; Couturier, B; Cowan, G A; Craik, D C; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dalseno, J; David, P; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Donleavy, S; Dordei, F; Dorigo, M; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dreimanis, K; Dujany, G; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elena, E; Elsasser, Ch; Ely, S; Esen, S; Evans, H-M; Evans, T; Falabella, A; Färber, C; Farinelli, C; Farley, N; Farry, S; Fay, R F; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fol, P; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garofoli, J; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gavardi, L; Gavrilov, G; Geraci, A; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianelle, A; Gianì, S; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Hussain, N; Hutchcroft, D; Hynds, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kelsey, M; Kenyon, I R; Ketel, T; Khanji, B; Khurewathanakul, C; Klaver, S; Klimaszewski, K; Kochebina, O; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Liles, M; Lindner, R; Linn, C; Lionetto, F; Liu, B; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lowdon, P; Lucchesi, D; Luo, H; Lupato, A; Luppi, E; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Malinin, A; Manca, G; Mancinelli, G; Mapelli, A; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Märki, R; Marks, J; Martellotti, G; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martinez Vidal, F; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Mazurov, A; McCann, M; McCarthy, J; McNab, A; McNulty, R; McSkelly, B; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M-N; Moggi, N; Molina Rodriguez, J; Monteil, S; Morandin, M; Morawski, P; Mordà, A; Morello, M J; Moron, J; Morris, A-B; Mountain, R; Muheim, F; Müller, K; Mussini, M; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neri, N; Neubert, S; Neufeld, N; Neuner, M; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Novoselov, A; O'Hanlon, D P; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Onderwater, G; Orlandea, M; Otalora Goicochea, J M; Otto, A; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palombo, F; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Pappalardo, L L; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrignani, C; Pazos Alvarez, A; Pearce, A; Pellegrino, A; Pepe Altarelli, M; Perazzini, S; Perez Trigo, E; Perret, P; Perrin-Terrin, M; Pescatore, L; Pesen, E; Petridis, K; Petrolini, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Pistone, A; Playfer, S; Plo Casasus, M; Polci, F; Poluektov, A; Polycarpo, E; Popov, A; Popov, D; Popovici, B; Potterat, C; Price, E; Price, J D; Prisciandaro, J; Pritchard, A; Prouve, C; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rachwal, B; Rademacker, J H; Rakotomiaramanana, B; Rama, M; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redi, F; Reichert, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, S; Rihl, M; Rinnert, K; Rives Molina, V; Robbe, P; Rodrigues, A B; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rotondo, M; Rouvinet, J; Ruf, T; Ruiz, H; Ruiz Valls, P; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salustino Guimaraes, V; Sanchez Mayordomo, C; Sanmartin Sedes, B; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sarti, A; Satriano, C; Satta, A; Saunders, D M; Savrie, M; Savrina, D; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M-H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Sepp, I; Serra, N; Serrano, J; Sestini, L; Seyfert, P; Shapkin, M; Shapoval, I; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, V; Shires, A; Silva Coutinho, R; Simi, G; Sirendi, M; Skidmore, N; Skillicorn, I; Skwarnicki, T; Smith, N A; Smith, E; Smith, E; Smith, J; Smith, M; Snoek, H; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Spradlin, P; Sridharan, S; Stagni, F; Stahl, M; Stahl, S; Steinkamp, O; Stenyakin, O; Stevenson, S; Stoica, S; Stone, S; Storaci, B; Stracka, S; Straticiuc, M; Straumann, U; Stroili, R; Subbiah, V K; Sun, L; Sutcliffe, W; Swientek, K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szilard, D; Szumlak, T; T'Jampens, S; Teklishyn, M; Tellarini, G; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Todd, J; Tolk, S; Tomassetti, L; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Ustyuzhanin, A; Uwer, U; Vacca, C; Vagnoni, V; Valenti, G; Vallier, A; Vazquez Gomez, R; Vazquez Regueiro, P; Vázquez Sierra, C; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vieites Diaz, M; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; de Vries, J A; Waldi, R; Wallace, C; Wallace, R; Walsh, J; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Websdale, D; Whitehead, M; Wicht, J; Wiedner, D; Wilkinson, G; Williams, M P; Williams, M; Wilschut, H W; Wilson, F F; Wimberley, J; Wishahi, J; Wislicki, W; Witek, M; Wormser, G; Wotton, S A; Wright, S; Wyllie, K; Xie, Y; Xing, Z; Xu, Z; Yang, Z; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L

2014-11-21

We present a measurement of the CP-violating weak mixing phase ϕs using the decay Bs(0)→Ds(+)Ds(-) in a data sample corresponding to 3.0 fb(-1) of integrated luminosity collected with the LHCb detector in pp collisions at center-of-mass energies of 7 and 8 TeV. An analysis of the time evolution of the system, which does not use the constraint |λ|=1 to allow for the presence of CP violation in decay, yields ϕs=0.02±0.17(stat)±0.02(syst)  rad, |λ|=0.91(-0.15)(+0.18)(stat)±0.02(syst). This result is consistent with the standard model expectation.

Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants.

PubMed

Conover, Gloria M; Martinez-Morales, Fernando; Heidtman, Matthew I; Luo, Zhao-Qing; Tang, May; Chen, Cui; Geiger, Otto; Isberg, Ralph R

2008-02-01

The function of phosphatidylcholine (PC) in the bacterial cell envelope remains cryptic. We show here that productive interaction of the respiratory pathogen Legionella pneumophila with host cells requires bacterial PC. Synthesis of the lipid in L. pneumophila was shown to occur via either phospholipid N-methyltransferase (PmtA) or phosphatidylcholine synthase (PcsA), but the latter pathway was demonstrated to be of predominant importance. Loss of PC from the cell envelope caused lowered yields of L. pneumophila within macrophages as well as loss of high multiplicity cytotoxicity, while mutants defective in PC synthesis could be complemented either by reintroduction of PcsA or by overproduction of PmtA. The lowered yields and reduced cytotoxicity in mutants with defective PC biosynthesis were due to three related defects. First, there was a poorly functioning Dot/Icm apparatus, which delivers substrates required for intracellular growth into the cytosol of infected cells. Second, there was reduced bacterial binding to macrophages, possibly due to loss of PC or a PC derivative on the bacterium that is recognized by the host cell. Finally, strains lacking PC had low steady-state levels of flagellin protein, a deficit that had been previously associated with the phenotypes of lowered cytotoxicity and poor cellular adhesion.

Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo[S

PubMed Central

Pynn, Christopher J.; Henderson, Neil G.; Clark, Howard; Koster, Grielof; Bernhard, Wolfgang; Postle, Anthony D.

2011-01-01

Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Although altered PC synthesis has been suggested to contribute to development of hepatocarcinoma and nonalcoholic steatohepatitis, analysis of the specificity of hepatic PC metabolism in human patients has been limited by the lack of sensitive and safe methodologies. Here we incorporated a deuterated methyl-d9-labled choline chloride, to quantify biosynthesis fluxes through both of the PC synthetic pathways in vivo in human volunteers and compared these fluxes with those in mice. Rates and molecular specificities of label incorporated into mouse liver and plasma PC were very similar and strongly suggest that label incorporation into human plasma PC can provide a direct measure of hepatic PC synthesis in human subjects. Importantly, we demonstrate for the first time that the PEMT pathway in human liver is selective for polyunsaturated PC species, especially those containing docosahexaenoic acid. Finally, we present a multiple isotopomer distribution analysis approach, based on transfer of deuterated methyl groups to S-adenosylmethionine and subsequent sequential methylations of PE, to quantify absolute flux rates through the PEMT pathway that are applicable to studies of liver dysfunction in clinical studies. PMID:21068006

Optical and nanomechanical study of anti-scratch layers on polycarbonate lenses

NASA Astrophysics Data System (ADS)

Charitidis, C.; Laskarakis, A.; Kassavetis, S.; Gravalidis, C.; Logothetidis, S.

2004-07-01

In recent years, as the optical-electronic industry developed, polymeric materials were gradually increasing in importance. Polycarbonate (PC) is a good candidate for eyewear applications due to its low weight and transparency. In the case of PC lenses, the deposition of anti-scratch (AS) coatings on the polymer surface is essential for the improvement of the mechanical behavior of the lens. In this work, we present a detailed investigation of the optical and nanomechanical properties of a PC based optical lens and coated by an AS coating as a protective overcoat. The study of the effect of the AS coating on the optical response of the PC lens has been performed by the use of Spectroscopic Ellipsometry (SE) in the IR spectral region, where the characteristic features corresponding to the different bonding configuration of the PC lens and the AS coating were studied. Also, the nanomechanical study of the PC lens, before and after the deposition of the AS coating, performed by nanoindentation measurements revealed the significant enhancement of the mechanical response of the AS/PC lens. More specifically, the AS/PC lens is characterized by enhanced values of hardness and elastic modulus. Finally, the use of AS coating has found to lead to a better scratch resistance and to the reduction of the coefficient of friction (μ) of the PC lens.

Aircraft Hydraulic Systems Dynamic Analysis

DTIC Science & Technology

1978-10-01

002O,30 DAoo DPV AtH Tapf1AR91 15017VLOL6l 2O 30117l t1 l .43# 1 S 11 C OATA--~8 T 0 PACT~?/PP TL/t 9PIIT b l’ I 0 AL91* E?’S/2 v T~f 1 U-M. 322 ...PRESSURE SLOT DO 160 toloWsl~pp 1P(IýPESPAtT,4 PSS) GO TO 162 OLEAX*(. ZESP -LPRFSS)*PLEAX*DT GO TO 164~ 16? L KUESL~S SPKD 164tqUFrRS!;-;4! ? L PP E

Photometric optimization and comparison of hybrid white LEDs for mesopic road lighting.

PubMed

Zhang, Chuanwen; Xiao, Licai; Zhong, Ping; He, Guoxing

2018-06-01

The photometric model for the mesopic luminous efficacy (LE m ) of hybrid white LEDs, including the radiant efficiency of both blue and red LEDs as well as the overall quantum efficiency of the phosphor layer or the quantum dot (QD) film, was developed. The optimal spectral parameters of integrated with quantum dots (QD-WLED), phosphor-converted white LED (pc-WLED) with red LEDs instead of red phosphor (pc/R WLED) for both color fidelity index (R f ) and color rendering index (R a ) above 70, 80, and 90 at correlated color temperatures of 2700-6500 K were obtained by maximizing the average LE m of four road lighting standards. By comparing among pc-WLED, QD-WLED, and pc/R WLED, it was suggested that the pc/R WLEDs make strong candidates for mesopic road lighting. The requirements of the overall efficiency of QD film were presented if the QD-WLEDs were competitive to the pc-WLEDs. Finally, the three real pc/R WLEDs with both R f and R a about 80 at CCTs of 2982 K, 4560 K, and 5683 K were demonstrated.

C-phycocyanin protects against low fertility by inhibiting reactive oxygen species in aging mice

PubMed Central

Li, Yan-Jiao; Han, Zhe; Ge, Lei; Zhou, Cheng-Jie; Zhao, Yue-Fang; Wang, Dong-Hui; Ren, Jing; Niu, Xin-Xin; Liang, Cheng-Guang

2016-01-01

Women over 35 have higher rates of infertility, largely due to deterioration of oocyte quality characterized by fragmentation, abnormal meiotic spindle-chromosome complexes, and oxidative stress. C-phycocyanin (PC) is a biliprotein enriched in Spirulina platensis that is known to possess antioxidant, anti-inflammatory, and radical-scavenging properties. D-galactose-induced aging acceleration in mice has been extensively used to study aging mechanisms and for pharmaceutical screening. In this study, adult female B6D2F/1 mice injected with D-galactose were used as a model to test the age-reversing effects of PC on degenerated reproductive ability. Our results show that PC can prevent oocyte fragmentation and aneuploidy by maintaining cytoskeletal integrity. Moreover, PC can reverse the expression of antioxidant genes, increase superoxide dismutase (SOD) activity and decrease methane dicarboxylic aldehyde (MDA) content, and normalize mitochondria distribution. PC exerts its benefit by inhibiting reactive oxygen species (ROS) production, which decreases apoptosis. Finally, we observe a significant increase in litter size after PC administration to D-galactose-induced aging mice. Our study demonstrates for the first time that D-galactose-induced impaired female reproductive capability can be partially rescued by the antioxidant effects of PC. PMID:27008700

A KINE-CHEMICAL INVESTIGATION OF THE AB DOR MOVING GROUP 'STREAM'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barenfeld, Scott A.; Bubar, Eric J.; Mamajek, Eric E.

2013-03-20

The AB Dor Moving Group consists of a 'nucleus' of {approx}10 stars at d {approx_equal} 20 pc, along with dozens of purported 'stream' members distributed across the sky. We perform a chemical and kinematic analysis of a subsample of AB Dor stream stars to test whether they constitute a physical stellar group. We use the NEMO Galactic kinematic code to investigate the orbits of the stream members, and perform a chemical abundance analysis using high resolution spectra taken with the Magellan Clay 6.5 m telescope. Using a {chi}{sup 2} test with the measured abundances for 10 different elements, we findmore » that only half of the purported AB Dor stream members could possibly constitute a statistically chemically homogeneous sample. Some stream members with three-dimensional velocities were hundreds of parsecs from the AB Dor nucleus {approx}10{sup 8} yr ago, and hence were unlikely to share a common origin. We conclude that the published lists of AB Dor moving group stream members are unlikely to represent the dispersed remnant of a single star formation episode. A subsample of the stream stars appears to be both statistically chemically homogeneous and in the vicinity of the AB Dor nucleus at birth. Their mean metallicity is [Fe/H] = 0.02 {+-} 0.02 dex, which we consider representative for the AB Dor group. Finally, we report a strong lower limit on the age of the AB Dor nucleus of >110 Myr based on the pre-main sequence contraction times for K-type members which have reached the main sequence.« less

A Kine-chemical Investigation of the AB Dor Moving Group "Stream"

NASA Astrophysics Data System (ADS)

Barenfeld, Scott A.; Bubar, Eric J.; Mamajek, Eric E.; Young, Patrick A.

2013-03-01

The AB Dor Moving Group consists of a "nucleus" of ~10 stars at d ~= 20 pc, along with dozens of purported "stream" members distributed across the sky. We perform a chemical and kinematic analysis of a subsample of AB Dor stream stars to test whether they constitute a physical stellar group. We use the NEMO Galactic kinematic code to investigate the orbits of the stream members, and perform a chemical abundance analysis using high resolution spectra taken with the Magellan Clay 6.5 m telescope. Using a χ2 test with the measured abundances for 10 different elements, we find that only half of the purported AB Dor stream members could possibly constitute a statistically chemically homogeneous sample. Some stream members with three-dimensional velocities were hundreds of parsecs from the AB Dor nucleus ~108 yr ago, and hence were unlikely to share a common origin. We conclude that the published lists of AB Dor moving group stream members are unlikely to represent the dispersed remnant of a single star formation episode. A subsample of the stream stars appears to be both statistically chemically homogeneous and in the vicinity of the AB Dor nucleus at birth. Their mean metallicity is [Fe/H] = 0.02 ± 0.02 dex, which we consider representative for the AB Dor group. Finally, we report a strong lower limit on the age of the AB Dor nucleus of >110 Myr based on the pre-main sequence contraction times for K-type members which have reached the main sequence.

Pulsed Gamma Rays from the Millisecond Pulsar J0030+0451 with the Fermi Large Area Telescope

DOE PAGES

Abdo, A. A.; Ackermann, M.; Atwood, W. B.; ...

2009-06-19

In this paper, we report the discovery of gamma-ray pulsations from the nearby isolated millisecond pulsar (MSP) PSR J0030+0451 with the Large Area Telescope on the Fermi Gamma-ray Space Telescope (formerly GLAST). This discovery makes PSR J0030+0451 the second MSP to be detected in gamma rays after PSR J0218+4232, observed by the EGRET instrument on the Compton Gamma-Ray Observatory. The spin-down power E(dotabove) = 3.5 x 10 33 erg s -1 is an order of magnitude lower than the empirical lower bound of previously known gamma-ray pulsars. The emission profile is characterized by two narrow peaks, 0.07 ± 0.01 andmore » 0.08 ± 0.02 wide, respectively, separated by 0.44 ± 0.02 in phase. The first gamma-ray peak falls 0.15 ± 0.01 after the main radio peak. The pulse shape is similar to that of the "normal" gamma-ray pulsars. An exponentially cutoff power-law fit of the emission spectrum leads to an integral photon flux above 100 MeV of (6.76 ± 1.05 ± 1.35) × 10 –8 cm –2 s –1 with cutoff energy (1.7 ± 0.4 ± 0.5) GeV. Finally, based on its parallax distance of (300 ± 90) pc, we obtain a gamma-ray efficiency L γ/E(dotabove) ≃ 15% for the conversion of spin-down energy rate into gamma-ray radiation, assuming isotropic emission.« less

Sandia National Laboratories: Employee & Retiree Resources

Science.gov Websites

, visit hbe.sandia.gov. Click on the group that applies to you - active represented, active non Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New

Sandia National Laboratories: Agreements

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New Projects, Non-Federal Entity (SPP/NFE) Agreements Sandia performs work on a reimbursable basis for a non

LANDFILLS AS BIOREACTORS: RESEARH AT THE OUTER LOOP LANDFILL, LOUISVILLE, KENTUCKY; FIRST INTERIM REPORT

EPA Science Inventory

Interim report resulting from a cooperative research and development agreement (CRADA) between US EP A's Officeof Research and Development - National Risk Management Research Laboratory and a n ongoing field demonstration
of municipal waste landfills being operated as bioreact...

IN SITU BIOREMEDIATION IN A LANDFILL: LEACHATE CHEMICAL AND MICROBIAL PARAMETERS

EPA Science Inventory

In recent years the conversion of landfills to landfill bioreactors has received increased attention owing to potential economic and waste treatment benefits. The U.S. EPA has entered into a Cooperative Research and Development Agreement (CRADA), with Waste Management Inc., testi...

Sandia National Laboratories: Pulsed-Power Science and Technology

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New and diagnostic tools to analyze results from Z and other experimental platforms. The results also

Glycobiology in yeast: production of bio-ative biopolymers and small molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scheller, Henrik

The accomplished goals of the CRADA were the establishment of a yeast strain capable of producing levels of vanillin suitable for commercial production and the identification of novel glycosyltransferases to construct the biosynthetic pathway of a gum Arabic-variant in yeast.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gatchett, A.M.; Fradkin, L.; Moore, M.

In 1986, the Federal Technology Transfer Act (FTTA) was established to promote a closer, collaborative relationship between federal government agencies and the private sector. With the increasing need for new cost-effective technologies to prevent and control pollution, both the US Environmental Protection Agency (EPA) and private industry are encouraged to facilitate the transfer of knowledge and technology under this Act. The FTTA removed several of the legal and institutional barriers to cooperative research that existed before the Act`s passage. Through the FTTA, the government strives to promote the movement of its products, processes, skills, and knowledge into the private sectormore » for further development and commercialization by encouraging the exchange of technical personnel and the sharing of facilities and other resources. Collaborative efforts between industry, federal agencies, and academia are made possible through cooperative research and development agreements (CRADAs). Forty-two CRADAs and five licensing agreements have been initiated with EPA under this program. This paper provides an overview of this new and innovative program within the EPA. 1 fig., 2 tabs.« less

Exploring the kinetics of gelation and final architecture of enzymatically cross-linked chitosan/gelatin gels.

PubMed

da Silva, Marcelo A; Bode, Franziska; Grillo, Isabelle; Dreiss, Cécile A

2015-04-13

Small-angle neutron scattering (SANS) was used to characterize the nanoscale structure of enzymatically cross-linked chitosan/gelatin hydrogels obtained from two protocols: a pure chemical cross-linking process (C), which uses the natural enzyme microbial transglutaminase, and a physical-co-chemical (PC) hybrid process, where covalent cross-linking is combined with the temperature-triggered gelation of gelatin, occurring through the formation of triple-helices. SANS measurements on the final and evolving networks provide a correlation length (ξ), which reflects the average size of expanding clusters. Their growth in PC gels is restricted by the triple-helices (ξ ∼ 10s of Å), while ξ in pure chemical gels increases with cross-linker concentration (∼100s of Å). In addition, the shear elastic modulus in PC gels is higher than in pure C gels. Our results thus demonstrate that gelatin triple helices provide a template to guide the cross-linking process; overall, this work provides important structural insight to improve the design of biopolymer-based gels.

The First Photometric Analysis of the Open Clusters Dolidze 32 and 36

NASA Astrophysics Data System (ADS)

Amin, M. Y.; Elsanhory, W. H.; Haroon, A. A.

2018-06-01

We present a first study of two open clusters Dolidze 32 and Dolidze 36 in the near-infrared region JHKs with the aid of PPMXL catalog. In our study, we used a method able to separate open cluster stars from those that belong to the stellar background. Our results of calculations indicate that for both cluster Dolidze 32 and Dolidze 36 the number of probable member is 286 and 780, respectively. We have estimated the cluster center for Dolidze 32 and Dolidze 36 are α = 18h41m4s.188 , δ = -04°04'57''.144 , α = 20h02m29s.95 , δ = 42°05'49''.2 , respectively. The limiting radius for both clusters Dolidze 32 and Dolidze 36 is about 0.94 ± 0.03 pc and 0.81 ± 0.03 pc, respectively. The Color Magnitude Diagram allows us to estimate the reddening E(B - V) = 1.41 ± 0.03 mag. for Dolidze 32 and E(B - V) = 0.19 ± 0.04 mag. for Dolidze 36 in such a way that the distance modulus (m - M) is 11.36 ± 0.02 and 10.10 ± 0.03 for both clusters, respectively. On the other hand, the luminosity and mass functions of these two open clusters, Dolidze 32 and Dolidze 36, have been estimated, showing that the estimated masses are 437 ± 21 M⊙ and 678 ± 26 M⊙, respectively, while the mass function slopes are -2.56 ± 0.62 and -2.01 ± 0.70 for Dolidze 32 and Dolidze 36, respectively. Finally, the dynamical state of these two clusters shows that only Dolidze 36 can be considered as a dynamically relaxed cluster.

Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.

PubMed

Yan, Jian; Jiang, Xinyin; West, Allyson A; Perry, Cydne A; Malysheva, Olga V; Brenna, J Thomas; Stabler, Sally P; Allen, Robert H; Gregory, Jesse F; Caudill, Marie A

2013-12-01

Although biomarkers of choline metabolism are altered by pregnancy, little is known about the influence of human pregnancy on the dynamics of choline-related metabolic processes. This study used stable isotope methodology to examine the effects of pregnancy on choline partitioning and the metabolic activity of choline-related pathways. Healthy third-trimester pregnant (n = 26; initially week 27 of gestation) and nonpregnant (n = 21) women consumed 22% of their total choline intake (480 or 930 mg/d) as methyl-d9-choline for the final 6 wk of a 12-wk feeding study. Plasma d9-betaine:d9-phosphatidylcholine (PC) was lower (P ≤ 0.04) in pregnant than in nonpregnant women, suggesting greater partitioning of choline into the cytidine diphosphate-choline (CDP-choline) PC biosynthetic pathway relative to betaine synthesis during pregnancy. Pregnant women also used more choline-derived methyl groups for PC synthesis via phosphatidylethanolamine N-methyltransferase (PEMT) as indicated by comparable increases in PEMT-PC enrichment in pregnant and nonpregnant women despite unequal (pregnant > nonpregnant; P < 0.001) PC pool sizes. Pregnancy enhanced the hydrolysis of PEMT-PC to free choline as shown by greater (P < 0.001) plasma d3-choline:d3-PC. Notably, d3-PC enrichment increased (P ≤ 0.011) incrementally from maternal to placental to fetal compartments, signifying the selective transfer of PEMT-PC to the fetus. The enhanced use of choline for PC production via both the CDP-choline and PEMT pathways shows the substantial demand for choline during late pregnancy. Selective partitioning of PEMT-PC to the fetal compartment may imply a unique requirement of PEMT-PC by the developing fetus.

Pectus Excavatum and Pectus Carinatum: Associated Conditions, Family History, and Postoperative Patient Satisfaction.

PubMed

Kuru, Pinar; Cakiroglu, Aylin; Er, Aynur; Ozbakir, Hincal; Cinel, Ali Emin; Cangut, Busra; Iris, Merve; Canbaz, Berkay; Pıçak, Ebru; Yuksel, Mustafa

2016-02-01

Pectus excavatum (PE) and pectus carinatum (PC) are the most common chest wall deformities. In this study, we aimed to characterize how patients obtained information about these deformities, as well as patients' family history, associated medical problems, and postoperative satisfaction after the Nuss and Abramson procedures. This cross-sectional retrospective study included patients who were operated by a single surgeon between 2006 and 2013. Follow-up calls were made after approval of our institution's ethics committee. We reached 207 of the 336 PE patients (61.6%) and 73 of the 96 PC patients (76%). The majority of the patients were male (85% of the PE patients and 91.8% of the PC patients). The age of diagnosis of PE was 14.52±0.51 years and the age at the time of operation was 17.89±0.42 years; for PC patients, the corresponding ages were 15.23±0.55 years and 16.77±0.55 years, respectively. A total of 70% of the PE patients and 63.8% of the PC patients obtained information about pectus deformities through the Internet. In 27.1% of the PE patients with an associated anomaly, 57.1% (n=13) had scoliosis, while 41.1% of the PC patients with an associated anomaly had kyphosis (n=5). Postoperative satisfaction, as evaluated on a scale from 0 to 10, was 8.17±0.15 for PE patients and 8.37±0.26 for PC patients. The postoperative pain duration was 51.93±5.18 days for PE patients and 38.5±6.88 days for PC patients. In this study, we found that most patients with pectus deformities were male. The Internet was an important resource for patients to learn about their deformities. Family history and associated anomalies were identified as important aspects for consideration in the clinical setting. The patients reported high levels of postoperative satisfaction, and pain management was found to be one of the most important elements of postoperative care.

Pectus Excavatum and Pectus Carinatum: Associated Conditions, Family History, and Postoperative Patient Satisfaction

PubMed Central

Kuru, Pinar; Cakiroglu, Aylin; Er, Aynur; Ozbakir, Hincal; Cinel, Ali Emin; Cangut, Busra; Iris, Merve; Canbaz, Berkay; Pıçak, Ebru; Yuksel, Mustafa

2016-01-01

Background Pectus excavatum (PE) and pectus carinatum (PC) are the most common chest wall deformities. In this study, we aimed to characterize how patients obtained information about these deformities, as well as patients’ family history, associated medical problems, and postoperative satisfaction after the Nuss and Abramson procedures. Methods This cross-sectional retrospective study included patients who were operated by a single surgeon between 2006 and 2013. Follow-up calls were made after approval of our institution’s ethics committee. We reached 207 of the 336 PE patients (61.6%) and 73 of the 96 PC patients (76%). Results The majority of the patients were male (85% of the PE patients and 91.8% of the PC patients). The age of diagnosis of PE was 14.52±0.51 years and the age at the time of operation was 17.89±0.42 years; for PC patients, the corresponding ages were 15.23±0.55 years and 16.77±0.55 years, respectively. A total of 70% of the PE patients and 63.8% of the PC patients obtained information about pectus deformities through the Internet. In 27.1% of the PE patients with an associated anomaly, 57.1% (n=13) had scoliosis, while 41.1% of the PC patients with an associated anomaly had kyphosis (n=5). Postoperative satisfaction, as evaluated on a scale from 0 to 10, was 8.17±0.15 for PE patients and 8.37±0.26 for PC patients. The postoperative pain duration was 51.93±5.18 days for PE patients and 38.5±6.88 days for PC patients. Conclusion In this study, we found that most patients with pectus deformities were male. The Internet was an important resource for patients to learn about their deformities. Family history and associated anomalies were identified as important aspects for consideration in the clinical setting. The patients reported high levels of postoperative satisfaction, and pain management was found to be one of the most important elements of postoperative care. PMID:26889443

Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation.

PubMed

Momi, N; Ponnusamy, M P; Kaur, S; Rachagani, S; Kunigal, S S; Chellappan, S; Ouellette, M M; Batra, S K

2013-03-14

Despite evidence that long-term smoking is the leading risk factor for pancreatic malignancies, the underlying mechanism(s) for cigarette-smoke (CS)-induced pancreatic cancer (PC) pathogenesis has not been well established. Our previous studies revealed an aberrant expression of the MUC4 mucin in PC as compared with the normal pancreas, and its association with cancer progression and metastasis. Interestingly, here we explore a potential link between MUC4 expression and smoking-mediated PC pathogenesis and report that both cigarette smoke extract and nicotine, which is the major component of CS, significantly upregulates MUC4 in PC cells. This nicotine-mediated MUC4 overexpression was via the α7 subunit of nicotinic acetylcholine receptor (nAChR) stimulation and subsequent activation of the JAK2/STAT3 downstream signaling cascade in cooperation with the MEK/ERK1/2 pathway; this effect was blocked by the α7nAChR antagonists, α-bungarotoxin and mecamylamine, and by specific siRNA-mediated STAT3 inhibition. In addition, we demonstrated that nicotine-mediated MUC4 upregulation promotes the PC cell migration through the activation of the downstream effectors, such as HER2, c-Src and FAK; this effect was attenuated by shRNA-mediated MUC4 abrogation, further implying that these nicotine-mediated pathological effects on PC cells are MUC4 dependent. Furthermore, the in vivo studies showed a marked increase in the mean pancreatic tumor weight (low dose (100 mg/m(3) total suspended particulate (TSP)), P=0.014; high dose (247 mg/m(3) TSP), P=0.02) and significant tumor metastasis to various distant organs in the CS-exposed mice, orthotopically implanted with luciferase-transfected PC cells, as compared with the sham controls. Moreover, the CS-exposed mice had elevated levels of serum cotinine (low dose, 155.88±35.96 ng/ml; high dose, 216.25±29.95 ng/ml) and increased MUC4, α7nAChR and pSTAT3 expression in the pancreatic tumor tissues. Altogether, our findings revealed for the first time that CS upregulates the MUC4 mucin in PC via the α7nAChR/JAK2/STAT3 downstream signaling cascade, thereby promoting metastasis of PC.

A revised estimate of the distance to the clouds in the Chamaeleon complex using the Tycho-Gaia Astrometric Solution

NASA Astrophysics Data System (ADS)

Voirin, Jordan; Manara, Carlo F.; Prusti, Timo

2018-03-01

Context. The determination of the distance to dark star-forming clouds is a key parameter to derive the properties of the cloud itself and of its stellar content. This parameter is still loosely constrained even in nearby star-forming regions. Aim. We want to determine the distances to the clouds in the Chamaeleon-Musca complex and explore the connection between these clouds and the large-scale cloud structures in the Galaxy. Methods: We used the newly estimated distances obtained from the parallaxes measured by the Gaia satellite and included in the Tycho-Gaia Astrometric Solution catalog. When known members of a region are included in this catalog we used their distances to infer the distance to the cloud. Otherwise, we analyzed the dependence of the color excess on the distance of the stars and looked for a turn-on of this excess, which is a proxy of the position of the front-edge of the star-forming cloud. Results: We are able to measure the distance to the three Chamaeleon clouds. The distance to Chamaeleon I is 179-10-10+11+11 pc, where the quoted uncertainties are statistical and systematic uncertainties, respectively, 20 pc further away than previously assumed. The Chamaeleon II cloud is located at the distance of 181-5-10+6+11 pc, which agrees with previous estimates. We are able to measure for the first time a distance to the Chamaeleon III cloud of 199-7-11+8+12 pc. Finally, the distance of the Musca cloud is smaller than 603-70-92+91+133 pc. These estimates do not allow us to distinguish between the possibility that the Chamaeleon clouds are part of a sheet of clouds parallel to the Galactic plane, or perpendicular to it. Conclusions: We measured a larger distance to the Chamaeleon I cloud than assumed in the past, confirmed the distance to the Chamaeleon II region, and measured for the first time the distance to the Chamaleon III cloud. These values are consistent with the scenario in which the three clouds are part of a single large-scale structure. Gaia Data Release 2 will allow us to put more stringent constraints on the distances to these clouds by giving us access to parallax measurements for a larger number of members of these regions. Tables 3-6 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/610/A64

21 CFR 640.91 - Processing.

Code of Federal Regulations, 2012 CFR

2012-04-01

... STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Plasma Protein Fraction (Human) § 640.91 Processing. (a) Date... °C or colder. (e) Heat treatment. Heating of the final containers of Plasma Protein Fraction (Human... concentration of the product. (g) Incubation. All final containers of Plasma Protein Fraction (Human) shall be...

21 CFR 640.91 - Processing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Plasma Protein Fraction (Human) § 640.91 Processing. (a) Date... °C or colder. (e) Heat treatment. Heating of the final containers of Plasma Protein Fraction (Human... concentration of the product. (g) Incubation. All final containers of Plasma Protein Fraction (Human) shall be...

21 CFR 640.91 - Processing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Plasma Protein Fraction (Human) § 640.91 Processing. (a) Date... °C or colder. (e) Heat treatment. Heating of the final containers of Plasma Protein Fraction (Human... concentration of the product. (g) Incubation. All final containers of Plasma Protein Fraction (Human) shall be...

21 CFR 640.91 - Processing.

Code of Federal Regulations, 2014 CFR

2014-04-01

... STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Plasma Protein Fraction (Human) § 640.91 Processing. (a) Date... °C or colder. (e) Heat treatment. Heating of the final containers of Plasma Protein Fraction (Human... concentration of the product. (g) Incubation. All final containers of Plasma Protein Fraction (Human) shall be...

A randomized clinical trial of tailored interventions for health promotion and recidivism reduction among homeless parolees: outcomes and cost analysis

PubMed Central

Zhang, Sheldon; Salem, Benissa E.; Farabee, David; Hall, Betsy; Marlow, Elizabeth; Faucette, Mark; Bond, Doug; Yadav, Kartik

2015-01-01

Objectives This study conducted a randomized controlled trial with 600 recently released homeless men exiting California jails and prisons. Methods The purpose of this study was to primarily ascertain how different levels of intensity in peer coaching and nurse-partnered intervention programs may impact reentry outcomes; specifically: (a) an intensive peer coach and nurse case managed (PC-NCM) program; (b) an intermediate peer coaching (PC) program with brief nurse counseling; and (c) the usual care (UC) program involving limited peer coaching and brief nurse counseling. Secondary outcomes evaluated the operational cost of each program. Results When compared to baseline, all three groups made progress on key health-related outcomes during the 12-month intervention period; further, 84.5 % of all participants eligible for hepatitis A/B vaccination completed their vaccine series. The results of the detailed operational cost analysis suggest the least costly approach (i.e., UC), which accounted for only 2.11 % of the total project expenditure, was as effective in achieving comparable outcomes for this parolee population as the PC-NCM and PC approaches, which accounted for 53.98 % and 43.91 %, respectively, of the project budget. Conclusions In this study, all three intervention strategies were found to be comparable in achieving a high rate of vaccine completion, which over time will likely produce tremendous savings to the public health system. PMID:27217822

Finite Element Analysis of IPS Empress II Ceramic Bridge Reinforced by Zirconia Bar

PubMed Central

Kermanshah, H.; Bitaraf, T.; Geramy, A.

2012-01-01

Objective: The aim of this study was to determine the effect of trenched zirconia bar on the von Mises stress distribution of IPS –Empress II core ceramics. Materials and Methods: The three-dimensional model including a three-unit bridge from the second premolar to the second molar was designed. The model was reinforced with zirconia bar (ZB), zirconia bar with vertical trench (VZB) and zirconia bar with horizontal trench (HZB) (cross sections of these bars were circular). The model without zirconia bar was designed as the control. The bridges were loaded by 200 N and 500 N on the occlusal surface at the middle of the pontic component and von Mises stresses were evaluated along a defined path. Results: In the connector area, von Mises stress in MPa were approximately identical in the specimens with ZB (at molar connector (MC): 4.75 and at premolar connector (PC): 6.40) and without ZB (MC: 5.50, PC: 6.68), and considerable differences were not recognized. Whereas, Von-Mises stress (MPa) in the specimens with horizontal trenched Zirconia bar (HZB) (MC: 3.91, PC: 2.44) and Vertical trenched Zirconia bar (VZB) (MC: 2.53, PC: 2.56) was decreased considerably. Conclusion: Embeded trenched zirconia bar could reinforce IPS-Empress II at the connector area which is a main failure region in all ceramic fixed partial dentures. PMID:23323181

Finite Element Analysis of IPS Empress II Ceramic Bridge Reinforced by Zirconia Bar.

PubMed

Kermanshah, H; Bitaraf, T; Geramy, A

2012-01-01

The aim of this study was to determine the effect of trenched zirconia bar on the von Mises stress distribution of IPS -Empress II core ceramics. The three-dimensional model including a three-unit bridge from the second premolar to the second molar was designed. The model was reinforced with zirconia bar (ZB), zirconia bar with vertical trench (VZB) and zirconia bar with horizontal trench (HZB) (cross sections of these bars were circular). The model without zirconia bar was designed as the control. The bridges were loaded by 200 N and 500 N on the occlusal surface at the middle of the pontic component and von Mises stresses were evaluated along a defined path. IN THE CONNECTOR AREA, VON MISES STRESS IN MPA WERE APPROXIMATELY IDENTICAL IN THE SPECIMENS WITH ZB (AT MOLAR CONNECTOR (MC): 4.75 and at premolar connector (PC): 6.40) and without ZB (MC: 5.50, PC: 6.68), and considerable differences were not recognized. Whereas, Von-Mises stress (MPa) in the specimens with horizontal trenched Zirconia bar (HZB) (MC: 3.91, PC: 2.44) and Vertical trenched Zirconia bar (VZB) (MC: 2.53, PC: 2.56) was decreased considerably. Embeded trenched zirconia bar could reinforce IPS-Empress II at the connector area which is a main failure region in all ceramic fixed partial dentures.

A randomized clinical trial of tailored interventions for health promotion and recidivism reduction among homeless parolees: outcomes and cost analysis.

PubMed

Nyamathi, Adeline M; Zhang, Sheldon; Salem, Benissa E; Farabee, David; Hall, Betsy; Marlow, Elizabeth; Faucette, Mark; Bond, Doug; Yadav, Kartik

2016-03-01

This study conducted a randomized controlled trial with 600 recently released homeless men exiting California jails and prisons. The purpose of this study was to primarily ascertain how different levels of intensity in peer coaching and nurse-partnered intervention programs may impact reentry outcomes; specifically: (a) an intensive peer coach and nurse case managed (PC-NCM) program; (b) an intermediate peer coaching (PC) program with brief nurse counseling; and (c) the usual care (UC) program involving limited peer coaching and brief nurse counseling. Secondary outcomes evaluated the operational cost of each program. When compared to baseline, all three groups made progress on key health-related outcomes during the 12-month intervention period; further, 84.5 % of all participants eligible for hepatitis A/B vaccination completed their vaccine series. The results of the detailed operational cost analysis suggest the least costly approach (i.e., UC), which accounted for only 2.11 % of the total project expenditure, was as effective in achieving comparable outcomes for this parolee population as the PC-NCM and PC approaches, which accounted for 53.98 % and 43.91 %, respectively, of the project budget. In this study, all three intervention strategies were found to be comparable in achieving a high rate of vaccine completion, which over time will likely produce tremendous savings to the public health system.

Hormone therapy use and physical quality of life in postmenopausal women with multiple sclerosis.

PubMed

Bove, Riley; White, Charles C; Fitzgerald, Kathryn C; Chitnis, Tanuja; Chibnik, Lori; Ascherio, Alberto; Munger, Kassandra L

2016-10-04

To determine the association between hormone therapy (HT) and physical quality of life (QOL) in postmenopausal women with multiple sclerosis (MS). We included female participants from the prospective Nurses' Health Study, with a diagnosis of definite or probable MS, who had completed a physical functioning assessment (PF10; subscale of the 36-Item Short-Form Health Survey QOL survey) at a time point between 3 and 10 years after their final menstrual period (early postmenopause). We assessed the association between HT use at this time point (never vs at least 12 months of systemic estrogen with/without progestin) and both PF10 and the 36-Item Short-Form Health Survey Physical Component Scale. We used a linear regression model adjusting for age, MS duration, menopause type and duration, and further for additional covariates (only ancestry was significant). Among 95 participants meeting all inclusion criteria at their first postmenopausal assessment, 61 reported HT use and 34 reported none. HT users differed from non-HT users in MS duration (p = 0.02) and menopause type (p = 0.01) but no other clinical or demographic characteristics. HT users had average PF10 scores that were 23 points higher than non-HT users (adjusted p = 0.004) and average Physical Component Scale scores that were 9.1 points higher in the 59 women with these available (adjusted p = 0.02). Longer duration of HT use was also associated with higher PF10 scores (p = 0.02, adjusted p = 0.06). Systemic HT use was associated with better physical QOL in postmenopausal women with MS in this observational study. Further studies are necessary to investigate causality. © 2016 American Academy of Neurology.

Sandia National Laboratories: Facts & Figures

Science.gov Websites

Technology Partnerships Business, Industry, & Non-Profits Government Universities Center for Development Agreement (CRADA) Strategic Partnership Projects, Non-Federal Entity (SPP/NFE) Agreements New 1,615.2 Defense Nuclear Nonproliferation 204.2 Other NNSA 1.2 NON-NNSA DOE 2,061.1M Energy & Threat

COOPERATIVE RESEARCH AND DEVELOPMENT FOR APPLICATION OF CFD TO ESTIMATING HUMAN EXPOSURES TO ENVIRONMENTAL POLLUTANTS

EPA Science Inventory

Under a Cooperative Research and Development Agreement (CRADA), Fluent, Inc. and the US EPA National Exposure Research Laboratory (NERL) propose to improve the ability of environmental scientists to use computer modeling for environmental exposure to air pollutants in human exp...

7 CFR 91.24 - Reports of test results.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Reports of test results. 91.24 Section 91.24... SERVICES AND GENERAL INFORMATION Reporting § 91.24 Reports of test results. (a) Results of analyses are... may call the appropriate Science and Technology laboratory for interim or final results prior to...

Pressure effect on the electronic transport properties of Fe1+yTe1-xSex

NASA Astrophysics Data System (ADS)

Arsenijević, Stevan; Gaál, Richard; Rønnow, Henrik; Viennois, Romain; Giannini, Enrico; van der Marel, Dirk; Forró, László

2012-02-01

We present a systematic study of electronic transport as function of pressure up to 25 kbar of Fe+yTe1-xSex single crystalline samples (with y=0.02, 0.05, and x=0, 0.2, and 0.3). Pressure is demonstrated to be a clean control parameter to drive the system with high Fe-excess through the metal-insulator (MIT) transition, in analogy with increasing the Se-doping or reducing the Fe-excess. The scaling of resistivity ρ(T, p) below 50 K identified a critical pressure of pc=8 kbar which separates non-metallic and metallic temperature dependences. At the pc the low-temperature sheet resistance is in the 6.5 kφ/square range. The Seebeck coefficient (S) at pc changes sign from negative to positive indicating a change in the electronic structure and in the balance between the electron and hole carriers. The S at the highest pressure exhibits low positive values similar to the metallic, superconducting cuprates. The critical MIT behavior, related to a quantum phase transition, indicates a universality of the Fe- and Cu-based high-Tc superconductors.

NREL Quickens its Tech Transfer Efforts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lammers, H.

2012-02-01

Innovations and 'aha' movements in renewable energy and energy efficiency, while exciting in the lab, only truly live up to their promise once they find a place in homes or business. Late last year President Obama issued a directive to all federal agencies to increase their efforts to transfer technologies to the private sector in order to achieve greater societal and economic impacts of federal research investments. The president's call to action includes efforts to establish technology transfer goals and to measure progress, to engage in efforts to increase the speed of technology transfer and to enhance local and regionalmore » innovation partnerships. But, even before the White House began its initiative to restructure the commercialization process, the National Renewable Energy Laboratory had a major effort underway designed to increase the speed and impact of technology transfer activities and had already made sure its innovations had a streamlined path to the private sector. For the last three years, NREL has been actively setting commercialization goals and tracking progress against those goals. For example, NREL sought to triple the number of innovations over a five-year period that began in 2009. Through best practices associated with inventor engagement, education and collaboration, NREL quadrupled the number of innovations in just three years. Similar progress has been made in patenting, licensing transactions, income generation and rewards to inventors. 'NREL is known nationally for our cutting-edge research and companies know to call us when they are ready to collaborate,' William Farris, vice president for commercialization and technology transfer, said. 'Once a team is ready to dive in, they don't want be mired in paperwork. We've worked to make our process for licensing NREL technology faster; it now takes less than 60 days for us to come to an agreement and start work with a company interested in our research.' While NREL maintains a robust patent portfolio, often companies are looking to do more than just license a technology. These relationships are invaluable in successfully moving technologies from NREL to the marketplace. 'We may generate new and potentially valuable innovations, but our commercialization partners do the heavy work of building a successful business around our technology,' Farris said. Tools such as CRADAs (Cooperative Research and Development Agreements) allow NREL to continue working with companies to refine and develop technologies. And, working with businesses is an area where NREL excels. NREL is responsible for one quarter of the CRADAs in the DOE system. 'When you look at the results of our CRADA program, you can demonstrate that we are actively engaged with companies in collaborating on research and moving technologies to market,' Farris said. NREL is first among DOE labs with 186 active CRADAs. And last year, NREL also was first with the number of new CRADAs signed. 'Part of the success in our working with industry goes back to NREL's mission to grow and support new industries,' Farris added. 'NREL has basic research capabilities, but we are never going to be the ultimate producer of a commercial product. That is the role of the private sector.' Farris also credits the advocacy and support that the Office of Energy Efficiency and Renewable Energy at DOE provides for these technology transfer activities. 'EERE's support is critical to our success,' Farris said. To assist the private sector in moving a technology from the lab to the manufacturing line, NREL has a number of programs in place to give that first, or even final, nudge toward commercialization. For instance, the Commercialization Assistance Program helps startups overcome technical barriers by granting free access to 40 hours of work at the lab. Through the Innovation and Entrepreneurship Center, NREL also helps clean energy businesses develop strong links with the financial community, as well as other key stakeholders in the commercialization process. In March, NREL formally opened the Colorado Center for Renewable Energy and Economic Development a cooperative program with the state of Colorado designed to bring together stakeholders and service providers that support the growth of cleantech companies. CREED currently is working with more than 25 stakeholders - governmental partners, universities, industry associations, venture capital organizations and small businesses - to improve the access these groups have to technologies developed at NREL and to provide services such as classes and workshops for entrepreneurs. When it comes to bringing together cleantech stakeholders, NREL's Industry Growth Forum is the marquee event. At the forum, clean energy entrepreneurs have the opportunity to present their business cases to an expert panel of investors and energy executives. Companies that have presented have raised $3.4 billion in funding to date.« less

Anchoring the Distance Scale via X-Ray/Infrared Data for Cepheid Clusters: SU Cas

NASA Astrophysics Data System (ADS)

Majaess, D.; Turner, D. G.; Gallo, L.; Gieren, W.; Bonatto, C.; Lane, D. J.; Balam, D.; Berdnikov, L.

2012-07-01

New X-ray (XMM-Newton) and JHKs (Observatoire du Mont-Mégantic) observations for members of the star cluster Alessi 95, which Turner et al. discovered hosts the classical Cepheid SU Cas, were used in tandem with UCAC3 (proper motion) and Two Micron All Sky Survey observations to determine precise cluster parameters: E(J - H) = 0.08 ± 0.02 and d = 405 ± 15 pc. The ensuing consensus among cluster, pulsation, and trigonometric distances (d=414+/- 5(\\sigma _{\\bar{x}}) +/- 10 (\\sigma) pc) places SU Cas in a select group of nearby fundamental Cepheid calibrators (δ Cep, ζ Gem). High-resolution X-ray observations may be employed to expand that sample as the data proved pertinent for identifying numerous stars associated with SU Cas. Acquiring X-ray observations of additional fields may foster efforts to refine Cepheid calibrations used to constrain H 0.

Clinical and radiological analysis of a series of periapical cysts and periapical granulomas diagnosed in a Brazilian population.

PubMed

Tavares, Daniel-Petitet; Rodrigues, Janderson-Teixeira; Dos Santos, Teresa-Cristina-Ribeiro-Bartholomeu; Armada, Luciana; Pires, Fábio-Ramôa

2017-01-01

Periapical cysts (PC) and periapical granulomas (PG) are the two most common chronic inflammatory periapical diseases, but their clinicoradiological characteristics can vary depending on the methods employed in each study. The aim of the present work was to analyze the clinical and radiological profile of a series of PC and PG diagnosed in a Brazilian population. The files of two Oral Pathology laboratories were reviewed and all cases diagnosed as PG and PC were selected for the study. Clinical and radiological information were retrieved and data were tabulated and descriptively and comparatively analyzed. Final sample was composed by 647 inflammatory periapical lesions, including 244 PG (38%) and 403 PC (62%). The number of women affected by PG was significantly higher than the number of women affected by PC ( p =0.037). Anterior region of the maxilla was the most common affected area for both entities (39% of the cases), but the most common anatomical location of PG (anterior maxilla and posterior maxilla) was different from PC (anterior maxilla and posterior mandible) ( p <0.0001). Upper lateral incisor was the most affected tooth. The mean radiological size of the PC was larger than the mean radiological size of the PG ( p <0.0001) and PC showed well-defined radiological images more frequently than PG ( p <0.0001). PC were more common than PG, both showed predilection for adult females, most lesions affected predominantly the anterior maxilla and PC presented larger mean radiological diameter and well-defined images when compared with PG. Key words: Periapical granuloma, periapical cyst, radicular cyst, diagnosis, Oral Pathology.

Bak-Sneppen model: Local equilibrium and critical value.

PubMed

Fraiman, Daniel

2018-04-01

The Bak-Sneppen (BS) model is a very simple model that exhibits all the richness of self-organized criticality theory. At the thermodynamic limit, the BS model converges to a situation where all particles have a fitness that is uniformly distributed between a critical value p_{c} and 1. The p_{c} value is unknown, as are the variables that influence and determine this value. Here we study the BS model in the case in which the lowest fitness particle interacts with an arbitrary even number of m nearest neighbors. We show that p_{c} verifies a simple local equilibrium relation. Based on this relation, we can determine bounds for p_{c} of the BS model and exact results for some BS-like models. Finally, we show how transformations of the original BS model can be done without altering the model's complex dynamics.

Bak-Sneppen model: Local equilibrium and critical value

NASA Astrophysics Data System (ADS)

Fraiman, Daniel

2018-04-01

The Bak-Sneppen (BS) model is a very simple model that exhibits all the richness of self-organized criticality theory. At the thermodynamic limit, the BS model converges to a situation where all particles have a fitness that is uniformly distributed between a critical value pc and 1. The pc value is unknown, as are the variables that influence and determine this value. Here we study the BS model in the case in which the lowest fitness particle interacts with an arbitrary even number of m nearest neighbors. We show that pc verifies a simple local equilibrium relation. Based on this relation, we can determine bounds for pc of the BS model and exact results for some BS-like models. Finally, we show how transformations of the original BS model can be done without altering the model's complex dynamics.

The Gould’s Belt Distances Survey (GOBELINS) II. Distances and Structure toward the Orion Molecular Clouds

NASA Astrophysics Data System (ADS)

Kounkel, Marina; Hartmann, Lee; Loinard, Laurent; Ortiz-León, Gisela N.; Mioduszewski, Amy J.; Rodríguez, Luis F.; Dzib, Sergio A.; Torres, Rosa M.; Pech, Gerardo; Galli, Phillip A. B.; Rivera, Juana L.; Boden, Andrew F.; Evans, Neal J., II; Briceño, Cesar; Tobin, John J.

2017-01-01

We present the results of the Gould’s Belt Distances Survey of young star-forming regions toward the Orion Molecular Cloud Complex. We detected 36 young stellar objects (YSOs) with the Very Large Baseline Array, 27 of which have been observed in at least three epochs over the course of two years. At least half of these YSOs belong to multiple systems. We obtained parallax and proper motions toward these stars to study the structure and kinematics of the Complex. We measured a distance of 388 ± 5 pc toward the Orion Nebula Cluster, 428 ± 10 pc toward the southern portion L1641, 388 ± 10 pc toward NGC 2068, and roughly ˜420 pc toward NGC 2024. Finally, we observed a strong degree of plasma radio scattering toward λ Ori.

The Intermediate Stellar Mass Population in R136 Determined from Hubble Space Telescope Planetary Camera 2 Images

NASA Astrophysics Data System (ADS)

Hunter, Deidre A.; Shaya, Edward J.; Holtzman, Jon A.; Light, Robert M.; O'Neil, Earl J., Jr.; Lynds, Roger

1995-07-01

We have analyzed Hubble Space Telescope (HST) images of the compact, luminous star cluster R136 in the LMC that were taken with the refurbished HST and new Wide Field/Planetary Camera. These images allow us to examine the stellar population in a region of unusually intense star formation at a scale of 0.01 pc. We have detected stars to 23.5 in F555W and have quantified the stellar population to an M555,0 of 0.9 or a mass of 2.8 Msun. Comparisons of HR diagrams with isochrones that were constructed for the HST flight filter system from theoretical stellar evolutionary tracks reveal massive stars, a main sequence to at least 2.8 Msun, and stars with M555,0 ≥ 0.5 still on pre-main sequence tracks. The average stellar population is fit with a 3-4 Myr isochrone. Contrary to expectations from star formation models, however, the formation period for the massive stars and lower mass stars appear to largely overlap. We have measured the IMF for stars 2.8-15 Msun in three annuli from 0.5-4.7 pc from the center of the cluster. The slopes of the IMF in all three annuli are the same within the uncertainties, thus, showing no evidence for mass segregation beyond 0.5 pc. Furthermore, the combined IMF slope, -122±006 is close to a normal Salpeter IMF. The lower mass limit must be lower than the limits of our measurements: ≤ 2.8 Msun beyond 0.5 pc and ≤ 7 Msun within 0.1 pc. This is contrary to some predictions that the lower mass limit could be as high as 10 Msun in regions of intense massive star formation. Integrated properties of R136 are consistent with its being comparable to a rather small globular cluster when such clusters were the same age as R136. From the surface brightness profile, an upper limit for the core radius of 0.02 pc is set. Within a radius of 0.4 pc we estimate that there have been roughly 20 crossing times and relaxation should be well along. Within 0.5 pc crowding prevents us from detecting the intermediate mass population, but there is a hint of an excess of stars brighter than M555,0 = -5 and of a deficit in the highest mass stars between 0.6 pc and 1.2 pc. This would be consistent with dynamical segregation.

VizieR Online Data Catalog: HST photometry in R136 (Hunter+ 1995)

NASA Astrophysics Data System (ADS)

Hunter, D. A.; Shaya, E. J.; Holtzman, J. A.; Light, R. M.; Oneil, Earl J., Jr.

1996-01-01

We have analyzed Hubble Space Telescope (HST) images of the compact, luminous star cluster R136 in the LMC that were taken with the refurbished HST and new Wide Field/Planetary Camera. These images allow us to examine the stellar population in a region of unusually intense star formation at a scale of 0.01pc. We have detected stars to 23.5 in F555W and have quantified the stellar population to an M_555.0 of 0.9 or a mass of 2.8M⊙. Comparisons of HR diagrams with isochrones that were constructed for the HST flight filter system from theoretical stellar evolutionary tracks reveal massive stars, a main sequence to at least 2.8M⊙, and stars with M_555.0>=0.5 still on pre-main sequence tracks. The average stellar population is fit with a 3-4Myr isochrone. Contrary to expectations from star formation models, however, the formation period for the massive stars and lower mass stars appear to largely overlap. We have measured the IMF for stars 2.8-15M⊙ in three annuli from 0.5-4.7pc from the center of the cluster. The slopes of the IMF in all three annuli are the same within the uncertainties, thus, showing no evidence for mass segregation beyond 0.5pc. Furthermore, the combined IMF slope, -1.22+/-0.06, is close to a normal Salpeter IMF. The lower mass limit must be lower than the limits of our measurements: <=2.8M⊙ beyond 0.5pc and <=7M⊙ within 0.1pc. This is contrary to some predictions that the lower mass limit could be as high as 10M⊙ in regions of intense massive star formation. Integrated properties of R136 are consistent with its being comparable to a rather small globular cluster when such clusters were the same age as R136. From the surface brightness profile, an upper limit for core radius of 0.02pc is set. Within a radius of 0.4pc we estimate that there have been roughly 20 crossing times and relaxation should be well along. Within 0.5pc crowding prevents us from detecting the intermediate mass population, but there is a hint of an excess of stars brighter than M_555.0=-5 and of a deficit in the highest mass stars between 0.6pc and 1.2pc. This would be consistent with dynamical segregation. (1 data file).

Principal Component Noise Filtering for NAST-I Radiometric Calibration

NASA Technical Reports Server (NTRS)

Tian, Jialin; Smith, William L., Sr.

2011-01-01

The National Polar-orbiting Operational Environmental Satellite System (NPOESS) Airborne Sounder Testbed- Interferometer (NAST-I) instrument is a high-resolution scanning interferometer that measures emitted thermal radiation between 3.3 and 18 microns. The NAST-I radiometric calibration is achieved using internal blackbody calibration references at ambient and hot temperatures. In this paper, we introduce a refined calibration technique that utilizes a principal component (PC) noise filter to compensate for instrument distortions and artifacts, therefore, further improve the absolute radiometric calibration accuracy. To test the procedure and estimate the PC filter noise performance, we form dependent and independent test samples using odd and even sets of blackbody spectra. To determine the optimal number of eigenvectors, the PC filter algorithm is applied to both dependent and independent blackbody spectra with a varying number of eigenvectors. The optimal number of PCs is selected so that the total root-mean-square (RMS) error is minimized. To estimate the filter noise performance, we examine four different scenarios: apply PC filtering to both dependent and independent datasets, apply PC filtering to dependent calibration data only, apply PC filtering to independent data only, and no PC filters. The independent blackbody radiances are predicted for each case and comparisons are made. The results show significant reduction in noise in the final calibrated radiances with the implementation of the PC filtering algorithm.

The Use of Adjuvant Nutrition to Preserve and Increase Lean Body Mass in AIDS Patients with Muscle Wasting.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2000-01-03

The studies conducted under this CRADA were aimed at determining if nutritional supplementation with HMb, in combination with glutamine and arginine can ameliorate the AIDS-associated wasting syndrome and in turn improve the clinical course of the disease.