3D Microfabrication Using Emulsion Mask Grayscale Photolithography Technique

NASA Astrophysics Data System (ADS)

Lee, Tze Pin; Mohamed, Khairudin

2016-02-01

Recently, the rapid development of technology such as biochips, microfluidic, micro-optical devices and micro-electromechanical-systems (MEMS) demands the capability to create complex design of three-dimensional (3D) microstructures. In order to create 3D microstructures, the traditional photolithography process often requires multiple photomasks to form 3D pattern from several stacked photoresist layers. This fabrication method is extremely time consuming, low throughput, costly and complicated to conduct for high volume manufacturing scale. On the other hand, next generation lithography such as electron beam lithography (EBL), focused ion beam lithography (FIB) and extreme ultraviolet lithography (EUV) are however too costly and the machines require expertise to setup. Therefore, the purpose of this study is to develop a simplified method in producing 3D microstructures using single grayscale emulsion mask technique. By using this grayscale fabrication method, microstructures of thickness as high as 500μm and as low as 20μm are obtained in a single photolithography exposure. Finally, the fabrication of 3D microfluidic channel has been demonstrated by using this grayscale photolithographic technique.

A plasma microlens for ultrashort high power lasers

NASA Astrophysics Data System (ADS)

Katzir, Yiftach; Eisenmann, Shmuel; Ferber, Yair; Zigler, Arie; Hubbard, Richard F.

2009-07-01

We present a technique for generation of miniature plasma lens system that can be used for focusing and collimating a high intensity femtosecond laser pulse. The plasma lens was created by a nanosecond laser, which ablated a capillary entrance. The spatial configuration of the ablated plasma focused a high intensity femtosecond laser pulse. This configuration offers versatility in the plasma lens small f-number for extremely tight focusing of high power lasers with no damage threshold restrictions of regular optical components.

Designing instrumented walker to measure upper-extremity's efforts: A case study.

PubMed

Khodadadi, Mohammad; Baniasad, Mina Arab; Arazpour, Mokhtar; Farahmand, Farzam; Zohoor, Hassan

2018-02-26

The high prevalence of shoulder pain in using walkers in patients who have spinal cord injury (SCI). Also, the limited options available to economically measure grip forces in walkers, which drove the need to create one. This article describes a method to obtain upper-extremities' forces and moments in a person with SCI by designing an appropriate instrumented walker. First, since the commercial multidirectional loadcells are too expensive, custom loadcells are fabricated. Ultimately, a complete gait analysis by means of VICON motion analysis and using inverse dynamic method has been held to measure upper-extremities' efforts. The results for a person with SCI using a two-wheel walker in low and high heights and a basic walker show that there are higher shoulder and elbow flexion-extension moments and also higher shoulder forces in superior-inferior direction and higher elbow and wrist forces in anterior-posterior directions. The results are not much different in using two different types of walker. By using the proposed method, upper-extremities' forces and moments were obtained and the results were compared to each other in using two different walkers.

An extremely bright gamma-ray pulsar in the Large Magellanic Cloud

NASA Astrophysics Data System (ADS)

Fermi LAT Collaboration; Ackermann, M.; Albert, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Barbieri, C.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bonino, R.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Cohen-Tanugi, J.; Cuoco, A.; Cutini, S.; D'Ammando, F.; Desiante, F. de Palma R.; Digel, S. W.; Di Venere, L.; Drell, P. S.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Franckowiak, A.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giordano, F.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Hagiwara, K.; Harding, A. K.; Hays, E.; Hewitt, J. W.; Hill, A. B.; Horan, D.; Johnson, T. J.; Knödlseder, J.; Kuss, M.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Li, J.; Li, L.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Maldera, S.; Manfreda, A.; Marshall, F.; Martin, P.; Mayer, M.; Mazziotta, M. N.; Michelson, P. F.; Mirabal, N.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Naletto, G.; Nuss, E.; Ohsugi, T.; Orienti, M.; Orlando, E.; Paneque, D.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reposeur, T.; Romani, R. W.; Parkinson, P. M. Saz; Schulz, A.; Sgrò, C.; Siskind, E. J.; Smith, D. A.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Takahashi, H.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Torres, D. F.; Uchiyama, Y.; Vianello, G.; Wood, K. S.; Wood, M.; Zampieri, L.

2015-11-01

Pulsars are rapidly spinning, highly magnetized neutron stars, created in the gravitational collapse of massive stars. We report the detection of pulsed giga-electron volt gamma rays from the young pulsar PSR J0540-6919 in the Large Magellanic Cloud, a satellite galaxy of the Milky Way. This is the first gamma-ray pulsar detected in another galaxy. It has the most luminous pulsed gamma-ray emission yet observed, exceeding the Crab pulsar’s by a factor of 20. PSR J0540-6919 presents an extreme test case for understanding the structure and evolution of neutron star magnetospheres.

Creating the Primordial Quark-Gluon Plasma at the LHC

NASA Astrophysics Data System (ADS)

Harris, John W.

2013-04-01

Ultra-relativistic collisions of heavy ions at the Large Hadron Collider (LHC) and the Relativistic Heavy Ion Collider (RHIC) create an extremely hot system at temperatures (T) expected only within the first microseconds after the Big Bang. At these temperatures (T ˜ 2 x 10^12 K), a few hundred thousand times hotter than the sun's core, the known ``elementary'' particles cannot exist and matter ``melts'' to form a ``soup'' of quarks and gluons, called the quark-gluon plasma (QGP). This ``soup'' flows easily, with extremely low viscosity, suggesting a nearly perfect hot liquid of quarks and gluons. Furthermore, the liquid is dense, highly interacting and opaque to energetic probes (fast quarks or gluons). RHIC has been in operation for twelve years and has established an impressive set of findings. Recent results from heavy ion collisions at the LHC extend the study of the QGP to higher temperatures and harder probes, such as jets (energetic clusters of particles), particles with extremely large transverse momenta and those containing heavy quarks. I will present a motivation for physics in the field and an overview of the new LHC heavy ion results in relation to results from RHIC.

Machinability of Stellite 6 hardfacing

NASA Astrophysics Data System (ADS)

Benghersallah, M.; Boulanouar, L.; Le Coz, G.; Devillez, A.; Dudzinski, D.

2010-06-01

This paper reports some experimental findings concerning the machinability at high cutting speed of nickel-base weld-deposited hardfacings for the manufacture of hot tooling. The forging work involves extreme impacts, forces, stresses and temperatures. Thus, mould dies must be extremely resistant. The aim of the project is to create a rapid prototyping process answering to forging conditions integrating a Stellite 6 hardfacing deposed PTA process. This study talks about the dry machining of the hardfacing, using a two tips machining tool and a high speed milling machine equipped by a power consumption recorder Wattpilote. The aim is to show the machinability of the hardfacing, measuring the power and the tip wear by optical microscope and white light interferometer, using different strategies and cutting conditions.

Perspectives on Leadership

DTIC Science & Technology

2008-01-01

LEADERSHIP -82- commitment ethic, stress management, and self esteem . The problematic indicators measured are aggression, deference, and change...Junior level followers usually have lower self - esteem , seek satisfaction outside of work, interrupt their careers, and receive more satisfaction from...justify an inflated view of their character, thereby exhibiting a self -righteous attitude and adds, an extremely “high self esteem creates a moral

Climate teleconnections, weather extremes, and vector-borne disease outbreaks

USDA-ARS?s Scientific Manuscript database

Fluctuations in climate lead to extremes in temperature, rainfall, flooding, and droughts. These climate extremes create ideal ecological conditions that promote mosquito-borne disease transmission that impact global human and animal health. One well known driver of such global scale climate fluctua...

Extreme Magnetic Storms: Their Characteristics and Possible Consequences for Humanity

NASA Astrophysics Data System (ADS)

Falkowski, B. J.; Tsurutani, B.; Lakhina, G. S.; Deng, Y.; Mannucci, A. J.

2015-12-01

The solar and interplanetary conditions necessary to create an extreme magnetic storm will be discussed. The Carrington 1859 event was not the largest possible. It will be shown that different facets of fast ICMEs/extreme magnetic storms will have different limitations. Some possible adverse effects of such extreme space weather events on society will be addressed.

Wetlands of the Prairie Pothole Region: Invertebrate species composition, ecology, and management

USGS Publications Warehouse

Euliss, N.H.; Wrubleski, D.A.; Mushet, D.M.; Batzer, D.P.; Rader, R.B.; Wissinger, S.A.

1999-01-01

The Prairie Pothole Region (PPR) of the United States and Canada is a unique area where shallow depressions created by the scouring action of Pleistocene glaciation interact with mid-continental climate variations to create and maintain a variety of wetland classes. These wetlands possess unique environmental and biotic characteristics that add to the overall regional diversity and production of aquatic invertebrates and the vertebrate wildlife that depend upon them as food. Climatic extremes in the PPR have a profound and dynamic influence on wetland hydrology, hydroperiod, chemistry, and ultimately the biota. Available knowledge of aquatic invertebrates in the PPR suggests that diversity of invertebrates within each wetland class is low. Harsh environmental conditions range from frigid winter temperatures that freeze wetlands and their sediments to hot summer temperatures and drought conditions that create steep salinity gradients and seasonally dry habitats. Consequently, the invertebrate community is composed mostly of ecological generalists that possess the necessary adaptations to tolerate environmental extremes. In this review, we describe the highly dynamic nature of prairie pothole wetlands and suggest that invertebrate studies be evaluated within a conceptual framework that considers important hydrologic, chemical, and climatic events.

Changing risks of resonance in extreme weather events for higher atmospheric greenhouse gas concentrations

NASA Astrophysics Data System (ADS)

Huntingford, Chris; Mitchell, Dann; Osprey, Scott

2015-04-01

A recent paper by Petoukhov et al (2013) demonstrates that many of the recent major extreme events in the NH may have been caused by resonant conditions driving very high meridional winds around slowly moving centres-of-action. Besides high amplitudes of planetary wave numbers 6,7 and 8, additional features are identified through 4 further conditions that trigger system resonance. These make the potential for high amplitude waves more likely as well as the possibility of more persistent events. A concern is that human-induced climate change could create conditions more conducive to tropospheric Rossby wave resonance, thereby forcing any periods of extreme weather to become more commonplace and longer lasting. Whilst the CMIP5 ensemble provides much information on expected changes, to fully address changing probabilities of extreme event occurrence - which by definition are relatively rare - is, though, best approached through a massive ensemble modeling framework. The climateprediction-dot-net citizen-science massive ensemble GCM modeling framework provides order 104 simulations for sea-surface temperature, sea-ice extent and atmospheric gas composition representative of both pre-industrial and contemporary conditions. Here we present what these families of simulations imply in terms of the changing likelihood of conditions for mid-latitude resonance, and implications for amplitudes of Rossby waves

Selective probing of mRNA expression levels within a living cell.

PubMed

Nawarathna, D; Turan, T; Wickramasinghe, H Kumar

2009-08-24

We report on a selective and nondestructive measurement of mRNA (messenger ribonucleic acid) expression levels within a living cell. We first modify an atomic force microscope tip to create a tapered nanoscale coaxial cable. Application of an ac (alternating potential) between the inner and outer electrodes of this cable creates a dielectrophoretic force attracting mRNA molecules toward the tip-end which is pretreated with gene specific primers. We selectively extracted and analyzed both high ( approximately 2500) and extremely low (11 0) copy number mRNA from a living cell mRNA in less than 10 s.

Gaining efficiency by centralising the corporate business resiliency process.

PubMed

Martinez, Robert

2017-06-01

Organisations have compiled many business continuity plans over the years in response to uncontrollable events and natural disasters. As the types of threats increase, even more plans are being created. Unfortunately, many corporations do not communicate the existence of these various plans outside of their centre of excellence. Creating a centralised oversight of your business resiliency process brings many benefits, including greater awareness, a bigger pool of expertise, common terminology and reducing the chances of redundant efforts. Having an overarching corporate response plan in place makes it possible to have high-level leadership trained and ready in case an extreme event occurs.

Bathed, Strained, Attenuated, Annihilated: Towards Quantum Optomechanics

NASA Astrophysics Data System (ADS)

Pepper, Brian Jeffrey

The field of optomechanics studies tiny devices that can be pushed mechanically by light. It is an extremely promising avenue towards tests of quantum mechanics on a macroscopic scale, by transferring quantum states of light to nano- or micromechanical objects. This dissertation concerns a long term research program to create quantum superpositions of a macroscopic mirror in an optomechanical cavity. This dissertation has two broad thrusts. The first focuses on microfabrication of a new type of device called optomechanical trampoline resonators, consisting of a small mirror on a cross-shaped tensed silicon nitride membrane. Devices have been fabricated with high mechanical and optical quality, including a 300 kHz device with quality factor 480,000, as well as a device of optical finesse 107,000. These devices are well into the sideband-resolved regime and suitable for optical cooling to the quantum ground state. One such device has been optically cooled to approximately 10 phonons. The second major thrust is theoretical. Creating a macroscopic superposition is a challenging problem, requiring optical cooling to the ground state, strong coupling, extremely high optical finesse and extremely low frequency. A realistic assessment of achievable parameters indicates that it is possible to achieve ground state cooling or strong coupling, but not both. This dissertation proposes a new technique using postselection to achieve macroscopic superpositions with only weak coupling. This relaxes some of the required parameters by orders of magnitude. Prospects for observing hypothetical novel decoherence mechanisms are also discussed.

An extremely bright gamma-ray pulsar in the Large Magellanic Cloud.

PubMed

2015-11-13

Pulsars are rapidly spinning, highly magnetized neutron stars, created in the gravitational collapse of massive stars. We report the detection of pulsed giga-electron volt gamma rays from the young pulsar PSR J0540-6919 in the Large Magellanic Cloud, a satellite galaxy of the Milky Way. This is the first gamma-ray pulsar detected in another galaxy. It has the most luminous pulsed gamma-ray emission yet observed, exceeding the Crab pulsar's by a factor of 20. PSR J0540-6919 presents an extreme test case for understanding the structure and evolution of neutron star magnetospheres. Copyright © 2015, American Association for the Advancement of Science.

The enhanced effects of antibiotics irradiated of extremely high frequency electromagnetic field on Escherichia coli growth properties.

PubMed

Torgomyan, Heghine; Trchounian, Armen

2015-01-01

The effects of extremely high frequency electromagnetic irradiation and antibiotics on Escherichia coli can create new opportunities for applications in different areas—medicine, agriculture, and food industry. Previously was shown that irradiated bacterial sensitivity against antibiotics was changed. In this work, it was presented the results that irradiation of antibiotics and then adding into growth medium was more effective compared with non-irradiated antibiotics bactericidal action. The selected antibiotics (tetracycline, kanamycin, chloramphenicol, and ceftriaxone) were from different groups. Antibiotics irradiation was performed with low intensity 53 GHz frequency during 1 h. The E. coli growth properties—lag-phase duration and specific growth rate—were markedly changed. Enhanced bacterial sensitivity to irradiated antibiotics is similar to the effects of antibiotics of higher concentrations.

Very high-resolution spectroscopy for extremely large telescopes using pupil slicing and adaptive optics.

PubMed

Beckers, Jacques M; Andersen, Torben E; Owner-Petersen, Mette

2007-03-05

Under seeing limited conditions very high resolution spectroscopy becomes very difficult for extremely large telescopes (ELTs). Using adaptive optics (AO) the stellar image size decreases proportional with the telescope diameter. This makes the spectrograph optics and hence its resolution independent of the telescope diameter. However AO for use with ELTs at visible wavelengths require deformable mirrors with many elements. Those are not likely to be available for quite some time. We propose to use the pupil slicing technique to create a number of sub-pupils each of which having its own deformable mirror. The images from all sub-pupils are combined incoherently with a diameter corresponding to the diffraction limit of the sub-pupil. The technique is referred to as "Pupil Slicing Adaptive Optics" or PSAO.

International Meeting on Simulation in Healthcare

DTIC Science & Technology

2010-02-01

wounds, burns, and injury . Participants will create reusable moulage items using realistic gel effects materials—designed to work seamlessly with...simulations of injuries and clinical encounters. Such technology provides extremely high levels of perceived realism and encourages suspension of disbelief...trace. The model gives an estimate of the cerebral flow reduction that occurs during early decelerations, including an estimate for vessel diameter

Concept cells through associative learning of high-level representations.

PubMed

Reddy, Leila; Thorpe, Simon J

2014-10-22

In this issue of Neuron, Quian Quiroga et al. (2014) show that neurons in the human medial temporal lobe (MTL) follow subjects' perceptual states rather than the features of the visual input. Patients with MTL damage however have intact perceptual abilities but suffer instead from extreme forgetfulness. Thus, the reported MTL neurons could create new memories of the current perceptual state.

Strangeness Production in the ALICE Experiment at the LHC

NASA Astrophysics Data System (ADS)

Johnson, Harold; Fenner, Kiara; Harton, Austin; Garcia-Solis, Edmundo; Soltz, Ron

2015-04-01

The study of strange particle production is an important tool in understanding the properties of a hot and dense medium, the quark-gluon plasma, created in heavy-ion collisions at ultra-relativistic energies. This quark-gluon plasma (QGP) is believed to have been present just after the big bang. The standard model of physics contains six types of quarks. Strange quarks are not among the valence quarks found in protons and neutrons. Strange quark production is sensitive to the extremely high temperatures of the QGP. CERN's Large Hadron Collider accelerates particles to nearly the speed of light before colliding them to create this QGP state. In the results of high-energy particle collisions, hadrons are formed out of quarks and gluons when cooling from extremely high temperatures. Jets are a highly collimated cone of particles coming from the hadronization of a single quark or gluon. Understanding jet interactions may give us clues about the QGP. Using FastJet (a popular jet finder algorithm), we extracted strangeness, or strange particle characteristics of jets contained within proton-proton collisions during our research at CERN. We have identified jets with and without strange particles in proton-proton collisions and we will present a comparison of pT spectra in both cases. This material is based upon work supported by the National Science Foundation under grants PHY-1305280 and PHY-1407051.

The Social Origins of Networks and Diffusion.

PubMed

Centola, Damon

2015-03-01

Recent research on social contagion has demonstrated significant effects of network topology on the dynamics of diffusion. However, network topologies are not given a priori. Rather, they are patterns of relations that emerge from individual and structural features of society, such as population composition, group heterogeneity, homophily, and social consolidation. Following Blau and Schwartz, the author develops a model of social network formation that explores how social and structural constraints on tie formation generate emergent social topologies and then explores the effectiveness of these social networks for the dynamics of social diffusion. Results show that, at one extreme, high levels of consolidation can create highly balkanized communities with poor integration of shared norms and practices. As suggested by Blau and Schwartz, reducing consolidation creates more crosscutting circles and significantly improves the dynamics of social diffusion across the population. However, the author finds that further reducing consolidation creates highly intersecting social networks that fail to support the widespread diffusion of norms and practices, indicating that successful social diffusion can depend on moderate to high levels of structural consolidation.

Laser programmable integrated circuit for forming synapses in neural networks

DOEpatents

Fu, C.Y.

1997-02-11

Customizable neural network in which one or more resistors form each synapse is disclosed. All the resistors in the synaptic array are identical, thus simplifying the processing issues. Highly doped, amorphous silicon is used as the resistor material, to create extremely high resistances occupying very small spaces. Connected in series with each resistor in the array is at least one severable conductor whose uppermost layer has a lower reflectivity of laser energy than typical metal conductors at a desired laser wavelength. 5 figs.

Process for forming synapses in neural networks and resistor therefor

DOEpatents

Fu, C.Y.

1996-07-23

Customizable neural network in which one or more resistors form each synapse is disclosed. All the resistors in the synaptic array are identical, thus simplifying the processing issues. Highly doped, amorphous silicon is used as the resistor material, to create extremely high resistances occupying very small spaces. Connected in series with each resistor in the array is at least one severable conductor whose uppermost layer has a lower reflectivity of laser energy than typical metal conductors at a desired laser wavelength. 5 figs.

Laser programmable integrated curcuit for forming synapses in neural networks

DOEpatents

Fu, Chi Y.

1997-01-01

Customizable neural network in which one or more resistors form each synapse. All the resistors in the synaptic array are identical, thus simplifying the processing issues. Highly doped, amorphous silicon is used as the resistor material, to create extremely high resistances occupying very small spaces. Connected in series with each resistor in the array is at least one severable conductor whose uppermost layer has a lower reflectivity of laser energy than typical metal conductors at a desired laser wavelength.

Process for forming synapses in neural networks and resistor therefor

DOEpatents

Fu, Chi Y.

1996-01-01

Customizable neural network in which one or more resistors form each synapse. All the resistors in the synaptic array are identical, thus simplifying the processing issues. Highly doped, amorphous silicon is used as the resistor material, to create extremely high resistances occupying very small spaces. Connected in series with each resistor in the array is at least one severable conductor whose uppermost layer has a lower reflectivity of laser energy than typical metal conductors at a desired laser wavelength.

Small world, big results : nanotechnology and forest products are teaming up to create the ?material of the 21st century?-?coated paper and paperboard

Treesearch

Phil Jones; T. H. Wegner

2007-01-01

At its fundamental level, wood is made up of nanodimensional cellulose nanocrystalline fibrils that have extremely high strength?approximately 25% the strength of carbon nanotubes. Because of this, plus our emerging ability to manipulate cell wall nano- dimensional architecture and functionality, the abundance of lignocellulosic materials, and our emerging ability to...

Subcutaneous Emphysema Mimicking Gas Gangrene Following Perforation of the Rectum: A Case Report

PubMed Central

Moon, Eun-Sun; Jung, Sung-Taek; Seo, Hyoung-Yeon

2004-01-01

We report a case of extensive subcutaneous emphysema of the lower extremity mimicking gas gangrene following perforation of the rectum in a 38-yr-old man. Subcutaneous emphysema of the leg may rarely occur secondary to perforation of the gastrointestinal tract and has often created serious diagnostic problems and high mortality rates. Therefore, prompt diagnosis and aggressive treatment is imperative. PMID:15483358

Layers of Seeing and Seeing through Layers: The Work of Art in the Age of Digital Imagery

ERIC Educational Resources Information Center

Ruby, Louisa Wood

2008-01-01

In consulting on or creating a Web site designed to use works of art for teaching purposes, it is extremely important to be aware of the differences between seeing an artwork "in the flesh" and in reproduction. Museum educators are highly aware of this disparity and are therefore eager to have students visit museums to experience authentic works…

Estimated smoldering probability: a new tool for predicting ground fire in the organic soils on the North Carolina Coastal Plain

Treesearch

James Reardon; Gary Curcio

2011-01-01

In the Southeastern United States, fires in pocosin wetlands and other similar vegetation communities with deep organic soils are a serious concern to fire managers. Highly flammable shrubs, such as gallberry and fetterbush, and small evergreen trees, such as red and loblolly bay, create the potential for extreme surface fire behavior. Moreover, deep organic soils...

Developing Home-Based Virtual Reality Therapy Interventions.

PubMed

Lin, Janice; Kelleher, Caitlin L; Engsberg, Jack R

2013-02-01

Stroke is one of the leading causes of serious long-term disability. However, home exercise programs given at rehabilitation often lack in motivational aspects. The purposes of this pilot study were (1) create individualized virtual reality (VR) games and (2) determine the effectiveness of VR games for improving movement in upper extremities in a 6-week home therapy intervention for persons with stroke. Participants were two individuals with upper extremity hemiparesis following a stroke. VR games were created using the Looking Glass programming language and modified based on personal interests, goals, and abilities. Participants were asked to play 1 hour each day for 6 weeks. Assessments measured upper extremity movement (range of motion and Action Research Arm Test [ARAT]) and performance in functional skills (Canadian Occupational Performance Measure [COPM] and Motor Activity Log [MAL]). Three VR games were created by a supervised occupational therapist student. The participants played approximately four to six times a week and performed over 100 repetitions of movements each day. Participants showed improvement in upper extremity movement and participation in functional tasks based on results from the COPM, ARAT, and MAL. Further development in the programming environment is needed to be plausible in a rehabilitation setting. Suggestions include graded-level support and continuation of creating a natural programming language, which will increase the ability to use the program in a rehabilitation setting. However, the VR games were shown to be effective as a home therapy intervention for persons with stroke. VR has the potential to advance therapy services by creating a more motivating home-based therapy service.

Selective probing of mRNA expression levels within a living cell

PubMed Central

Nawarathna, D.; Turan, T.; Wickramasinghe, H. Kumar

2009-01-01

We report on a selective and nondestructive measurement of mRNA (messenger ribonucleic acid) expression levels within a living cell. We first modify an atomic force microscope tip to create a tapered nanoscale coaxial cable. Application of an ac (alternating potential) between the inner and outer electrodes of this cable creates a dielectrophoretic force attracting mRNA molecules toward the tip-end which is pretreated with gene specific primers. We selectively extracted and analyzed both high (∼2500) and extremely low (11¯0) copy number mRNA from a living cell mRNA in less than 10 s. PMID:19777090

Increasing synchrony of high temperature and low flow in western North American streams: double trouble for coldwater biota?

USGS Publications Warehouse

Arismendi, Ivan; Safeeq, Mohammad; Johnson, Sherri L.; Dunham, Jason B.; Haggerty, Roy

2013-01-01

Flow and temperature are strongly linked environmental factors driving ecosystem processes in streams. Stream temperature maxima (Tmax_w) and stream flow minima (Qmin) can create periods of stress for aquatic organisms. In mountainous areas, such as western North America, recent shifts toward an earlier spring peak flow and decreases in low flow during summer/fall have been reported. We hypothesized that an earlier peak flow could be shifting the timing of low flow and leading to a decrease in the interval between Tmax_w and Qmin. We also examined if years with extreme low Qmin were associated with years of extreme high Tmax_w. We tested these hypotheses using long32 term data from 22 minimally human-influenced streams for the period 1950-2010. We found trends toward a shorter time lag between Tmax_w and Qmin over time and a strong negative association between their magnitudes. Our findings show that aquatic biota may be increasingly experiencing narrower time windows to recover or adapt between these extreme events of low flow and high temperature. This study highlights the importance of evaluating multiple environmental drivers to better gauge the effects of the recent climate variability in freshwaters.

Assessing the Regional Frequency, Intensity, and Spatial Extent of Tropical Cyclone Rainfall

NASA Astrophysics Data System (ADS)

Bosma, C.; Wright, D.; Nguyen, P.

2017-12-01

While the strength of a hurricane is generally classified based on its wind speed, the unprecedented rainfall-driven flooding experienced in southeastern Texas during Hurricane Harvey clearly highlights the need for better understanding of the hazards associated with extreme rainfall from hurricanes and other tropical systems. In this study, we seek to develop a framework for describing the joint probabilistic and spatio-temporal properties of extreme rainfall from hurricanes and other tropical systems. Furthermore, we argue that commonly-used terminology - such as the "500-year storm" - fail to convey the true properties of tropical cyclone rainfall occurrences in the United States. To quantify the magnitude and spatial extent of these storms, a database consisting of hundreds of unique rainfall volumetric shapes (or "voxels") was created. Each voxel is a four-dimensional object, created by connecting, in both space and time, gridded rainfall observations from the daily, gauge-based NOAA CPC-Unified precipitation dataset. Individual voxels were then associated with concurrent tropical cyclone tracks from NOAA's HURDAT-2 archive, to create distinct representations of the rainfall associated with every Atlantic tropical system making landfall over (or passing near) the United States since 1948. Using these voxels, a series of threshold-excess extreme value models were created to estimate the recurrence intervals of extreme tropical cyclone rainfall, both nationally and locally, for single and multi-day timescales. This voxel database also allows for the "indexing" of past events, placing recent extremes - such as the 50+ inches of rain observed during Hurricane Harvey - into a national context and emphasizing how rainfall totals that are rare at the point scale may be more frequent from a regional perspective.

Levitation Performance of Two Opposed Permanent Magnet Pole-Pair Separated Conical Bearingless Motors

NASA Technical Reports Server (NTRS)

Kascak, Peter; Jansen, Ralph; Dever, Timothy; Nagorny, Aleksandr; Loparo, Kenneth

2013-01-01

In standard motor applications, rotor suspension with traditional mechanical bearings represents the most economical solution. However, in certain high performance applications, rotor suspension without contacting bearings is either required or highly beneficial. Examples include applications requiring very high speed or extreme environment operation, or with limited access for maintenance. This paper expands upon a novel bearingless motor concept, in which two motors with opposing conical air-gaps are used to achieve full five-axis levitation and rotation of the rotor. Force in this motor is created by deliberately leaving the motor s pole-pairs unconnected, which allows the creation of different d-axis flux in each pole pair. This flux imbalance is used to create lateral force. This approach is different than previous bearingless motor designs, which require separate windings for levitation and rotation. This paper examines the predicted and achieved suspension performance of a fully levitated prototype bearingless system.

Modeling of skin cooling, blood flow, and optical properties in wounds created by electrical shock

NASA Astrophysics Data System (ADS)

Nguyen, Thu T. A.; Shupp, Jeffrey W.; Moffatt, Lauren T.; Jordan, Marion H.; Jeng, James C.; Ramella-Roman, Jessica C.

2012-02-01

High voltage electrical injuries may lead to irreversible tissue damage or even death. Research on tissue injury following high voltage shock is needed and may yield stage-appropriate therapy to reduce amputation rate. One of the mechanisms by which electricity damages tissue is through Joule heating, with subsequent protein denaturation. Previous studies have shown that blood flow had a significant effect on the cooling rate of heated subcutaneous tissue. To assess the thermal damage in tissue, this study focused on monitoring changes of temperature and optical properties of skin next to high voltage wounds. The burns were created between left fore limb and right hind limb extremities of adult male Sprague-Dawley rats by a 1000VDC delivery shock system. A thermal camera was utilized to record temperature variation during the exposure. The experimental results were then validated using a thermal-electric finite element model (FEM).

Water storage equity and safety assurance policy to mitigate potential 'dual-extreme cumulative threats' in agricultural catchments

NASA Astrophysics Data System (ADS)

Pisaniello, John D.; Tingey-Holyoak, Joanne L.

2017-02-01

Farm dams that are not managed properly at the individual level can create water storage equity and safety threats to downstream communities and the environment that aggregate at the catchment level: a potential 'dual-extreme cumulative' problem. The paper provides indicative evidence and develops understanding of this novel phenomenon and associated policy needs within the Australian setting comprising dual hydrologic extremes of floods and droughts, further exacerbated by climate change. This is achieved through comparative case studies involving surveys of both dam owner perceptions and dam management practices in four States representing a complete range of integrated policy approaches from weak to strong. Survey results find most farmers do not believe dam maintenance is important, will undertake spillway blocking and do not plan for emergencies. These results are supported by physical on-site findings of farmers neglecting dams and blocking or under-designing spillways, in turn storing more water than they are entitled and creating unsafe dams at both the individual and cumulative levels. From detailed cross-case comparative assessment against policy context, it emerges that on-farm perceptions and practices form a range of 'acceptability' of dam management that directly reflects policy strength and integration in each setting. The paper advances the international small dams policy, agricultural water management and hydrology literatures, evidencing the need for effective integrated policy to mitigate dual extreme cumulative threats. Importantly, guidance is provided to jurisdictions internationally with high inter-annual rainfall variation on how best to design integrated policy that can achieve both water storage equity and safety in agricultural catchments.

Use of computer games as an intervention for stroke.

PubMed

Proffitt, Rachel M; Alankus, Gazihan; Kelleher, Caitlin L; Engsberg, Jack R

2011-01-01

Current rehabilitation for persons with hemiparesis after stroke requires high numbers of repetitions to be in accordance with contemporary motor learning principles. The motivational characteristics of computer games can be harnessed to create engaging interventions for persons with hemiparesis after stroke that incorporate this high number of repetitions. The purpose of this case report was to test the feasibility of using computer games as a 6-week home therapy intervention to improve upper extremity function for a person with stroke. One person with left upper extremity hemiparesis after stroke participated in a 6-week home therapy computer game intervention. The games were customized to her preferences and abilities and modified weekly. Her performance was tracked and analyzed. Data from pre-, mid-, and postintervention testing using standard upper extremity measures and the Reaching Performance Scale (RPS) were analyzed. After 3 weeks, the participant demonstrated increased upper extremity range of motion at the shoulder and decreased compensatory trunk movements during reaching tasks. After 6 weeks, she showed functional gains in activities of daily living (ADLs) and instrumental ADLs despite no further improvements on the RPS. Results indicate that computer games have the potential to be a useful intervention for people with stroke. Future work will add additional support to quantify the effectiveness of the games as a home therapy intervention for persons with stroke.

Acquisition of the Navy Rapid Airborne Mine Clearance System

DTIC Science & Technology

2007-04-11

will fire a supercavitating * projectile from the MH-60S helicopter using laser targeting. By supercavitating , the projectile maintains its...258 Mod 1 Armor Piercing Fin Stabilized Discarding Sabot Tracer cartridge (the Mod 1 incorporates a modified projectile nose to allow supercavitation ... Supercavitation is the use of cavitation (forcing water to move at extremely high speed) effects to create a bubble of air around the projectile, which enables

The Impact of the Geologic History and Paleoclimate on the Diversification of East African Cichlids

PubMed Central

Danley, Patrick D.; Husemann, Martin; Ding, Baoqing; DiPietro, Lyndsay M.; Beverly, Emily J.; Peppe, Daniel J.

2012-01-01

The cichlid fishes of the East African Great Lakes are the largest extant vertebrate radiation identified to date. These lakes and their surrounding waters support over 2,000 species of cichlid fish, many of which are descended from a single common ancestor within the past 10 Ma. The extraordinary East African cichlid diversity is intricately linked to the highly variable geologic and paleoclimatic history of this region. Greater than 10 Ma, the western arm of the East African rift system began to separate, thereby creating a series of rift basins that would come to contain several water bodies, including the extremely deep Lakes Tanganyika and Malawi. Uplifting associated with this rifting backponded many rivers and created the extremely large, but shallow Lake Victoria. Since their creation, the size, shape, and existence of these lakes have changed dramatically which has, in turn, significantly influenced the evolutionary history of the lakes' cichlids. This paper reviews the geologic history and paleoclimate of the East African Great Lakes and the impact of these forces on the region's endemic cichlid flocks. PMID:22888465

MaRIE: an experimental facility concept revolutionizing materials in extremes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnes, Cris W

The Matter-Radiation Interactions in Extremes (MaRIE) project intends to create an experimental facility that will revolutionize the control of materials in extremes. That control extends to extreme regimes where solid material has failed and begins to flow - the regimes of fluid dynamics and turbulent mixing. This presentation introduces the MaRIE facility concept, demonstrates examples of the science case that determine its functional requirements, and kicks-off the discussion of the decadal scientific challenges of mixing in extremes, including those MaRIE might address.

Development and initial psychometric evaluation of an item bank created to measure upper extremity function in persons with stroke.

PubMed

Higgins, Johanne; Finch, Lois E; Kopec, Jacek; Mayo, Nancy E

2010-02-01

To create and illustrate the development of a method to parsimoniously and hierarchically assess upper extremity function in persons after stroke. Data were analyzed using Rasch analysis. Re-analysis of data from 8 studies involving persons after stroke. Over 4000 patients with stroke who participated in various studies in Montreal and elsewhere in Canada. Data comprised 17 tests or indices of upper extremity function and health-related quality of life, for a total of 99 items related to upper extremity function. Tests and indices included, among others, the Box and Block Test, the Nine-Hole Peg Test and the Stroke Impact Scale. Data were collected at various times post-stroke from 3 days to 1 year. Once the data fit the model, a bank of items measuring upper extremity function with persons and items organized hierarchically by difficulty and ability in log units was produced. This bank forms the basis for eventual computer adaptive testing. The calibration of the items should be tested further psychometrically, as should the interpretation of the metric arising from using the item calibration to measure the upper extremity of individuals.

Matrices pattern using FIB; 'Out-of-the-box' way of thinking.

PubMed

Fleger, Y; Gotlib-Vainshtein, K; Talyosef, Y

2017-03-01

Focused ion beam (FIB) is an extremely valuable tool in nanopatterning and nanofabrication for potentially high-resolution patterning, especially when refers to He ion beam microscopy. The work presented here demonstrates an 'out-of-the-box' method of writing using FIB, which enables creating very large matrices, up to the beam-shift limitation, in short times and with high accuracy unachievable by any other writing technique. The new method allows combining different shapes in nanometric dimensions and high resolutions for wide ranges. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Photonic crystal fiber Fabry-Perot interferometers with high-reflectance internal mirrors

NASA Astrophysics Data System (ADS)

Fan, Rong; Hou, Yuanbin; Sun, Wei

2015-06-01

We demonstrated an in-line micro fiber-optic Fabry-Perot interferometer with an air cavity which was created by multi-step fusion splicing a muti-mode photonic crystal fiber (MPCF) to a standard single mode fiber (SMF). The fringe visibility of the interference pattern was up to 20 dB by reshaping the air cavity. Experimental results showed that such a device could be used as a highly sensitive strain sensor with the sensitivity of 4.5 pm/μɛ. Moreover, it offered some other outstanding advantages, such as the extremely compact structure, easy fabrication, low cost, and high accuracy.

Science & Technology Review September/October 2008

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bearinger, J P

2008-07-21

This issue has the following articles: (1) Answering Scientists Most Audacious Questions--Commentary by Dona Crawford; (2) Testing the Accuracy of the Supernova Yardstick--High-resolution simulations are advancing understanding of Type Ia supernovae to help uncover the mysteries of dark energy; (3) Developing New Drugs and Personalized Medical Treatment--Accelerator mass spectrometry is emerging as an essential tool for assessing the effects of drugs in humans; (4) Triage in a Patch--A painless skin patch and accompanying detector can quickly indicate human exposure to biological pathogens, chemicals, explosives, or radiation; and (5) Smoothing Out Defects for Extreme Ultraviolet Lithography--A process for smoothing mask defectsmore » helps move extreme ultraviolet lithography one step closer to creating smaller, more powerful computer chips.« less

Counteracting Rotor Imbalance in a Bearingless Motor System with Feedforward Control

NASA Technical Reports Server (NTRS)

Kascak, Peter Eugene; Jansen, Ralph H.; Dever, Timothy; Nagorny, Aleksandr; Loparo, Kenneth

2012-01-01

In standard motor applications, traditional mechanical bearings represent the most economical approach to rotor suspension. However, in certain high performance applications, rotor suspension without bearing contact is either required or highly beneficial. Such applications include very high speed, extreme environment, or limited maintenance access applications. This paper extends upon a novel bearingless motor concept, in which full five-axis levitation and rotation of the rotor is achieved using two motors with opposing conical air-gaps. By leaving the motors' pole-pairs unconnected, different d-axis flux in each pole-pair is created, generating a flux imbalance which creates lateral force. Note this is approach is different than that used in previous bearingless motors, which use separate windings for levitation and rotation. This paper will examine the use of feedforward control to counteract synchronous whirl caused by rotor imbalance. Experimental results will be presented showing the performance of a prototype bearingless system, which was sized for a high speed flywheel energy storage application, with and without feedforward control.

Extreme-Scale Bayesian Inference for Uncertainty Quantification of Complex Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biros, George

Uncertainty quantification (UQ)—that is, quantifying uncertainties in complex mathematical models and their large-scale computational implementations—is widely viewed as one of the outstanding challenges facing the field of CS&E over the coming decade. The EUREKA project set to address the most difficult class of UQ problems: those for which both the underlying PDE model as well as the uncertain parameters are of extreme scale. In the project we worked on these extreme-scale challenges in the following four areas: 1. Scalable parallel algorithms for sampling and characterizing the posterior distribution that exploit the structure of the underlying PDEs and parameter-to-observable map. Thesemore » include structure-exploiting versions of the randomized maximum likelihood method, which aims to overcome the intractability of employing conventional MCMC methods for solving extreme-scale Bayesian inversion problems by appealing to and adapting ideas from large-scale PDE-constrained optimization, which have been very successful at exploring high-dimensional spaces. 2. Scalable parallel algorithms for construction of prior and likelihood functions based on learning methods and non-parametric density estimation. Constructing problem-specific priors remains a critical challenge in Bayesian inference, and more so in high dimensions. Another challenge is construction of likelihood functions that capture unmodeled couplings between observations and parameters. We will create parallel algorithms for non-parametric density estimation using high dimensional N-body methods and combine them with supervised learning techniques for the construction of priors and likelihood functions. 3. Bayesian inadequacy models, which augment physics models with stochastic models that represent their imperfections. The success of the Bayesian inference framework depends on the ability to represent the uncertainty due to imperfections of the mathematical model of the phenomena of interest. This is a central challenge in UQ, especially for large-scale models. We propose to develop the mathematical tools to address these challenges in the context of extreme-scale problems. 4. Parallel scalable algorithms for Bayesian optimal experimental design (OED). Bayesian inversion yields quantified uncertainties in the model parameters, which can be propagated forward through the model to yield uncertainty in outputs of interest. This opens the way for designing new experiments to reduce the uncertainties in the model parameters and model predictions. Such experimental design problems have been intractable for large-scale problems using conventional methods; we will create OED algorithms that exploit the structure of the PDE model and the parameter-to-output map to overcome these challenges. Parallel algorithms for these four problems were created, analyzed, prototyped, implemented, tuned, and scaled up for leading-edge supercomputers, including UT-Austin’s own 10 petaflops Stampede system, ANL’s Mira system, and ORNL’s Titan system. While our focus is on fundamental mathematical/computational methods and algorithms, we will assess our methods on model problems derived from several DOE mission applications, including multiscale mechanics and ice sheet dynamics.« less

Soil heating during the complete combustion of mega-logs and broadcast burning in central Oregon USA pumice soils

Treesearch

Jane E. Smith; Ariel D. Cowan; Stephen A. Fitzgerald

2016-01-01

The environmental effect of extreme soil heating, such as occurs with the complete combustion of large downed wood during wildfires, is a post-fire management concern to forest managers. To address this knowledge gap, we stacked logs to create ‘mega-log’ burning conditions and compared the temperature, duration and penetration of the soil heat pulse in nine high...

Influence of changing surface temperature gradients on mid-latitudinal circulation and western hemispheric summer temperature extremes

NASA Astrophysics Data System (ADS)

Kornhuber, Kai; Hoffmann, Peter; Coumou, Dim

2017-04-01

Many recent summers in the Northern hemisphere (NH) mid-latitudes have seen severe heatwaves (2003, 2004, 2009, 2010, 2012, 2015, (Black et al. 2004; Diffenbaugh & Scherer 2013; Russo et al. 2014; Hoy et al. 2016)). During many of those extremes the mid-latitudinal tropospheric circulation was characterized by an amplified, quasi-stationary and hemispheric wave pattern with a dominant influence of wavenumber seven (Coumou et al. 2014; Petoukhov et al. 2016; Kornhuber et al. 2016). Analyzing NH summer reanalysis data we show that the position where these heat extremes occur is not arbitrary. If the amplitude of wave seven is large, the wave gets "locked" in a specific preferred phase position. As a consequence of this phase-locking behavior some regions are more likely to experience extreme weather during high-amplitude events. Meridional wind speeds associated with the preferred phase are particularly strong over longitudes of the western hemisphere (180°W - 40°E) leading to positive temperature anomalies over the US and Western Europe. Using a widely-used blocking-index we demonstrate that longitudes over these regions experience an increased probability of blocking during high amplitude wave seven events. We show that during the above mentioned extreme summers, amplified waves were locked in their preferred phase-position creating the right dynamical background condition for severe heatwaves to occur. Further, regression analyses reveal that a pronounced Ocean - Land temperature contrast (Tdiff) and weak poleward surface temperature gradient (dT/dy) are associated with an amplified wave seven in its preferred phase-position. Our study suggests that the observed positive trend in Tdiff and negative trend in dT/dy favors the occurrence of high-amplitude, quasi-stationary wave seven in its preferred phase position and therefore persistent heatwaves in the US and western Europe.

Effect of salinity on locomotor performance and thermal extremes of metamorphic Andean Toads (Rhinella spinulosa) from Monte Desert, Argentina.

PubMed

Sanabria, Eduardo; Quiroga, Lorena; Vergara, Cristina; Banchig, Mariana; Rodriguez, Cesar; Ontivero, Emanuel

2018-05-01

Rhinella spinulosa is distributed from Peru to Argentina (from 1200 to 5000 m elevation), inhabiting arid mountain valleys of the Andes, characterized by salty soils. The variations in soil salinity, caused by high evapotranspiration of water, can create an osmotic constraint and high thermal oscillations for metamorphsed Andean toad (R. spinulosa), affecting their thermoregulation and extreme thermal tolerances. We investigated the changes in thermal tolerance parameters (critical thermal maximum and crystallization temperature) of a population of metamorphosed R. spinulosa from the Monte Desert of San Juan, Argentina, under different substrate salinity conditions. Our results suggest that the locomotor performance of metamorphs of R. spinulosa is affected by increasing salinity concentrations in the environment where they develop. On the other hand, the thermal extremes of metamorphs of R. spinulosa also showed changes associated with different salinity conditions. According to other studies on different organisms, the increase of the osmolarity of the internal medium may increase the thermal tolerance of this species. More studies are needed to understand the thermo-osmolar adjustments of the metamorphs of toads to environmental variability. Copyright © 2018 Elsevier Ltd. All rights reserved.

Creating a global sub-daily precipitation dataset

NASA Astrophysics Data System (ADS)

Lewis, Elizabeth; Blenkinsop, Stephen; Fowler, Hayley

2017-04-01

Extremes of precipitation can cause flooding and droughts which can lead to substantial damages to infrastructure and ecosystems and can result in loss of life. It is still uncertain how hydrological extremes will change with global warming as we do not fully understand the processes that cause extreme precipitation under current climate variability. The INTENSE project is using a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales, leading to improved high-resolution climate model representation of extreme rainfall processes. The INTENSE project is in conjunction with the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges Project (GEWEX) Science questions. The first step towards achieving this is to construct a new global sub-daily precipitation dataset. Data collection is ongoing and already covers North America, Europe, Asia and Australasia. Comprehensive, open source quality control software is being developed to set a new standard for verifying sub-daily precipitation data and a set of global hydroclimatic indices will be produced based upon stakeholder recommendations. This will provide a unique global data resource on sub-daily precipitation whose derived indices, e.g. monthly/annual maxima, will be freely available to the wider scientific community.

Evaluation of high pressure water blast with rotating spray bar for removing paint and rubber deposits from airport runways, and review of runway slipperiness problems created by rubber contamination

NASA Technical Reports Server (NTRS)

Horne, W. B.; Griswold, G. D.

1975-01-01

A high pressure water blast with rotating spray bar treatment for removing paint and rubber deposits from airport runways is studied. The results of the evaluation suggest that the treatment is very effective in removing above surface paint and rubber deposits to the point that pavement skid resistance is restored to trafficked but uncontaminated runway surface skid resistance levels. Aircraft operating problems created by runway slipperiness are reviewed along with an assessment of the contributions that pavement surface treatments, surface weathering, traffic polishing, and rubber deposits make in creating or alleviating runway slipperiness. The results suggest that conventional surface treatments for both portland cement and asphaltic concrete runways are extremely vulnerable to rubber deposit accretions which can produce runway slipperiness conditions for aircraft operations as or more slippery than many snow and ice-covered runway conditions. Pavement grooving surface treatments are shown to be the least vulnerable to rubber deposits accretion and traffic polishing of the surface treatments examined.

Patterns of precipitation and soil moisture extremes in Texas, US: A complex network analysis

NASA Astrophysics Data System (ADS)

Sun, Alexander Y.; Xia, Youlong; Caldwell, Todd G.; Hao, Zengchao

2018-02-01

Understanding of the spatial and temporal dynamics of extreme precipitation not only improves prediction skills, but also helps to prioritize hazard mitigation efforts. This study seeks to enhance the understanding of spatiotemporal covariation patterns embedded in precipitation (P) and soil moisture (SM) by using an event-based, complex-network-theoretic approach. Events concurrences are quantified using a nonparametric event synchronization measure, and spatial patterns of hydroclimate variables are analyzed by using several network measures and a community detection algorithm. SM-P coupling is examined using a directional event coincidence analysis measure that takes the order of event occurrences into account. The complex network approach is demonstrated for Texas, US, a region possessing a rich set of hydroclimate features and is frequented by catastrophic flooding. Gridded daily observed P data and simulated SM data are used to create complex networks of P and SM extremes. The uncovered high degree centrality regions and community structures are qualitatively in agreement with the overall existing knowledge of hydroclimate extremes in the study region. Our analyses provide new visual insights on the propagation, connectivity, and synchronicity of P extremes, as well as the SM-P coupling, in this flood-prone region, and can be readily used as a basis for event-driven predictive analytics for other regions.

Extreme Geohazards: Reducing the Disaster Risk and Increasing Resilience

NASA Astrophysics Data System (ADS)

Plag, Hans-Peter; Stein, Seth; Brocklebank, Sean; Jules-Plag, Shelley; Marsh, Stuart; Campus, Paola

2013-04-01

Extreme geohazards have the potential to escalate the global sustainability crisis and put us close to the boundaries of the safe operating space for humanity. Exposure of human assets to geohazards has increased dramatically in recent decades, and the sensitivity of the built environment and the embedded socio-economic fabric have changed. We are putting the urban environment, including megacities, in harm's way. Paradoxically, innovation during recent decades, in particular, urban innovation, has increased the disaster risk and coupled this risk to the sustainability crisis. Only more innovation can reduce disaster risk and lead us out of the sustainability crisis. Extreme geohazards (volcanic eruptions, earthquakes, tsunamis) that occurred regularly throughout the last few millennia mostly did not cause major disasters because population density was low and the built environment was not sprawling into hazardous areas to the same extent as today. Similar extreme events today would cause unparalleled damage on a global scale and could worsen the sustainability crisis. Simulation of these extreme hazards under present conditions can help to assess the disaster risk. The Geohazards Community of Practice of the Group on Earth Observations (GEO) with support from the European Science Foundation is preparing a white paper assessing the contemporary disaster risks associated with extreme geohazards and developing a vision for science and society to engage in deliberations addressing this risk (see http://www.geohazcop.org/projects/extgeowp). Risk awareness and monitoring is highly uneven across the world, and this creates two kinds of problems. Firstly, potential hazards are much more closely monitored in wealthy countries than in the developing world. But the largest hazards are global in nature, and it is critical to get as much forewarning as possible to develop an effective response. The disasters and near-misses of the past show that adherence to scientific knowledge, particularly during the early warning phase, can reduce disasters. This suggests that a strong global monitoring system for geohazards is needed, not least to support the early detection of extreme hazards. Secondly, low risk awareness combined with poverty, corruption, and a lack of building codes and informed land use management creates the conditions to turn hazards into disasters throughout much of the developing world. Democratizing knowledge about extreme geohazards is very important in order to inform deliberations of disaster risks and community strategies that can reduce the disaster risk by increasing resilience and adaptive capacities without compromising the livelihood of communities. We use a four-order scheme to define disaster risk outcomes and associated societal processes. This framework can be implemented in the context of deliberative democracy and governance with participation of the community. The current dialog between science and society is not fully capable of supporting deliberative governance and a democratizing of knowledge. Most scientific knowledge is created independent of those who could put it to use, and a transition to co-design and co-development of knowledge involving a broad stakeholder base is necessary to address the disaster risk associated with extreme events. This transition may have the consequence of more responsibility and even liability for science.

KSC-2009-2947

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – An X-band radar waits to be installed on the U.S. Army landing craft utility ship Brandy Station in Port Canaveral, Fla. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2950

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a crane lowers the X-band radar onto the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

World Epidemiology Review, Number 87.

DTIC Science & Technology

1977-10-13

If fruits and vegetables are eaten raw, they must be washed with extreme care and salads liberally dressed with vinegar . "Water for washing raw...34 ( fermented corn beverage) and other products which may be con- taminated. "The consumption of food sold on the street," said a source, "creates a...discussed the sale of chicha ( fermented corn beverage) and ice cream with the high SAS official. "In the case of ice cream," they explained, "there

Self-Assembled Array of Tethered Manganese Oxide Nanoparticles for the Next Generation of Energy Storage

PubMed Central

Stevens, Tyler E.; Pearce, Charles J.; Whitten, Caleah N.; Grant, Richard P.; Monson, Todd C.

2017-01-01

Many challenges must be overcome in order to create reliable electrochemical energy storage devices with not only high energy but also high power densities. Gaps exist in both battery and supercapacitor technologies, with neither one satisfying the need for both large power and energy densities in a single device. To begin addressing these challenges (and others), we report a process to create a self-assembled array of electrochemically active nanoparticles bound directly to a current collector using extremely short (2 nm or less) conductive tethers. The tethered array of nanoparticles, MnO in this case, bound directly to a gold current collector via short conducting linkages eliminates the need for fillers, resulting in a material which achieves 99.9% active material by mass (excluding the current collector). This strategy is expected to be both scalable as well as effective for alternative tethers and metal oxide nanoparticles. PMID:28287183

Beam test results of STS prototype modules for the future accelerator experiments FAIR/CBM and NICA/MPD projects

NASA Astrophysics Data System (ADS)

Kharlamov, Petr; Dementev, Dmitrii; Shitenkov, Mikhail

2017-10-01

High-energy heavy-ion collision experiments provide the unique possibility to create and investigate extreme states of strongly-interacted matter and address the fundamental aspects of QCD. The experimental investigation the QCD phase diagram would be a major breakthrough in our understanding of the properties of nuclear matter. The reconstruction of the charged particles created in the nuclear collisions, including the determination of their momenta, is the central detection task in high-energy heavy-ion experiments. It is taken up by the Silicon Tracking System in CBM@FAIR and by Inner Tracker in MPD@NICA currently under development. These experiments requires very fast and radiation hard detectors, a novel data read-out and analysis concept including free streaming front-end electronics. Thermal and beam tests of prototype detector modules for these tracking systems showed the stability of sensors and readout electronics operation.

Extreme Experiences and Asking the Unaskable: An Interview with Ted Sizer.

ERIC Educational Resources Information Center

Minton, Elaine

1996-01-01

The renowned educational reformer talks about how memorable, "extreme" learning experiences have shaped his views on education; how to create collegial support; the things that have given him satisfaction; his father's influence on him; the irrepressible optimism of teenagers; taking advantage of serendipitous events; and how questioning…

Environmental Symposium Held in Crystal City, Virginia on May 5-6, 1992

DTIC Science & Technology

1992-05-01

addition, the Act creat a new program designed to prevent sudden, accidental releases of extremely hazardo substances . Generally, the Act sets forth a... prevent of sudden, The owner or operator of any facility handling an extremely hazardous substance will also be required to prepare and implement a risk...management plan to detect and prevent or minimize the potential for an accidental release of extremely hazardous substances . EPA may require that such

High Spatial Resolution Thermal Satellite Technologies

NASA Technical Reports Server (NTRS)

Ryan, Robert

2003-01-01

This document in the form of viewslides, reviews various low-cost alternatives to high spatial resolution thermal satellite technologies. There exists no follow-on to Landsat 7 or ASTER high spatial resolution thermal systems. This document reviews the results of the investigation in to the use of new technologies to create a low-cost useful alternative. Three suggested technologies are examined. 1. Conventional microbolometer pushbroom modes offers potential for low cost Landsat Data Continuity Mission (LDCM) thermal or ASTER capability with at least 60-120 ground sampling distance (GSD). 2. Backscanning could produce MultiSpectral Thermal Imager performance without cooled detectors. 3. Cooled detector could produce hyperspectral thermal class system or extremely high spatial resolution class instrument.

Realistic facial expression of virtual human based on color, sweat, and tears effects.

PubMed

Alkawaz, Mohammed Hazim; Basori, Ahmad Hoirul; Mohamad, Dzulkifli; Mohamed, Farhan

2014-01-01

Generating extreme appearances such as scared awaiting sweating while happy fit for tears (cry) and blushing (anger and happiness) is the key issue in achieving the high quality facial animation. The effects of sweat, tears, and colors are integrated into a single animation model to create realistic facial expressions of 3D avatar. The physical properties of muscles, emotions, or the fluid properties with sweating and tears initiators are incorporated. The action units (AUs) of facial action coding system are merged with autonomous AUs to create expressions including sadness, anger with blushing, happiness with blushing, and fear. Fluid effects such as sweat and tears are simulated using the particle system and smoothed-particle hydrodynamics (SPH) methods which are combined with facial animation technique to produce complex facial expressions. The effects of oxygenation of the facial skin color appearance are measured using the pulse oximeter system and the 3D skin analyzer. The result shows that virtual human facial expression is enhanced by mimicking actual sweating and tears simulations for all extreme expressions. The proposed method has contribution towards the development of facial animation industry and game as well as computer graphics.

Realistic Facial Expression of Virtual Human Based on Color, Sweat, and Tears Effects

PubMed Central

Alkawaz, Mohammed Hazim; Basori, Ahmad Hoirul; Mohamad, Dzulkifli; Mohamed, Farhan

2014-01-01

Generating extreme appearances such as scared awaiting sweating while happy fit for tears (cry) and blushing (anger and happiness) is the key issue in achieving the high quality facial animation. The effects of sweat, tears, and colors are integrated into a single animation model to create realistic facial expressions of 3D avatar. The physical properties of muscles, emotions, or the fluid properties with sweating and tears initiators are incorporated. The action units (AUs) of facial action coding system are merged with autonomous AUs to create expressions including sadness, anger with blushing, happiness with blushing, and fear. Fluid effects such as sweat and tears are simulated using the particle system and smoothed-particle hydrodynamics (SPH) methods which are combined with facial animation technique to produce complex facial expressions. The effects of oxygenation of the facial skin color appearance are measured using the pulse oximeter system and the 3D skin analyzer. The result shows that virtual human facial expression is enhanced by mimicking actual sweating and tears simulations for all extreme expressions. The proposed method has contribution towards the development of facial animation industry and game as well as computer graphics. PMID:25136663

Free electron laser-driven ultrafast rearrangement of the electronic structure in Ti

PubMed Central

Principi, E.; Giangrisostomi, E.; Cucini, R.; Bencivenga, F.; Battistoni, A.; Gessini, A.; Mincigrucci, R.; Saito, M.; Di Fonzo, S.; D'Amico, F.; Di Cicco, A.; Gunnella, R.; Filipponi, A.; Giglia, A.; Nannarone, S.; Masciovecchio, C.

2015-01-01

High-energy density extreme ultraviolet radiation delivered by the FERMI seeded free-electron laser has been used to create an exotic nonequilibrium state of matter in a titanium sample characterized by a highly excited electron subsystem at temperatures in excess of 10 eV and a cold solid-density ion lattice. The obtained transient state has been investigated through ultrafast absorption spectroscopy across the Ti M2,3-edge revealing a drastic rearrangement of the sample electronic structure around the Fermi level occurring on a time scale of about 100 fs. PMID:26798835

On the design of experiments for the study of extreme field limits in the ultra-relativistic interaction of electromagnetic waves with plasmas

NASA Astrophysics Data System (ADS)

Bulanov, Sergei V.; Esirkepov, Timur Z.; Hayashi, Yukio; Kando, Masaki; Kiriyama, Hiromitsu; Koga, James K.; Kondo, Kiminori; Kotaki, Hideyuki; Pirozhkov, Alexander S.; Bulanov, Stepan S.; Zhidkov, Alexei G.; Chen, Pisin; Neely, David; Kato, Yoshiaki; Narozhny, Nikolay B.; Korn, Georg

2011-06-01

The critical electric field of quantum electrodynamics, called also the Schwinger field, is so strong that it produces electron-positron pairs from vacuum, converting the energy of light into matter. Since the dawn of quantum electrodynamics, there has been a dream on how to reach it on Earth. With the rise of laser technology this field has become feasible through the construction of extremely high power lasers or/and with the sophisticated use of nonlinear processes in relativistic plasmas. This is one of the most attractive motivations for extremely high power laser development, i.e. producing matter from vacuum by pure light in fundamental process of quantum electrodynamics in the nonperturbative regime. Recently it has been realized that a laser with intensity well below the Schwinger limit can create an avalanche of electron-positron pairs similar to a discharge before attaining the Schwinger field. It has also been realized that the Schwinger limit can be reached using an appropriate configuration of laser beams. In experiments on the collision of laser light and high intensity electromagnetic pulses generated by relativistic flying mirrors, with electron bunches produced by a conventional accelerator and with laser wake field accelerated electrons the studying of extreme field limits in the nonlinear interaction of electromagnetic waves is proposed. The regimes of dominant radiation reaction, which completely changes the electromagnetic wave-matter interaction, will be revealed. This will result in a new powerful source of high brightness gamma-rays. A possibility of the demonstration of the electronpositron pair creation in vacuum via multi-photon processes can be realized. This will allow modeling under terrestrial laboratory conditions neutron star magnetospheres, cosmological gamma ray bursts and the Leptonic Era of the Universe.

Using Weather Types to Understand and Communicate Weather and Climate Impacts

NASA Astrophysics Data System (ADS)

Prein, A. F.; Hale, B.; Holland, G. J.; Bruyere, C. L.; Done, J.; Mearns, L.

2017-12-01

A common challenge in atmospheric research is the translation of scientific advancements and breakthroughs to decision relevant and actionable information. This challenge is central to the mission of NCAR's Capacity Center for Climate and Weather Extremes (C3WE, www.c3we.ucar.edu). C3WE advances our understanding of weather and climate impacts and integrates these advances with distributed information technology to create tools that promote a global culture of resilience to weather and climate extremes. Here we will present an interactive web-based tool that connects historic U.S. losses and fatalities from extreme weather and climate events to 12 large-scale weather types. Weather types are dominant weather situations such as winter high-pressure systems over the U.S. leading to very cold temperatures or summertime moist humid air masses over the central U.S. leading to severe thunderstorms. Each weather type has a specific fingerprint of economic losses and fatalities in a region that is quantified. Therefore, weather types enable a direct connection of observed or forecasted weather situation to loss of life and property. The presented tool allows the user to explore these connections, raise awareness of existing vulnerabilities, and build resilience to weather and climate extremes.

Early Detection of Lightning Caused Wildfires and Prediction of Wildfire Behavior through Energy Distribution, Atmospherics, Geophysics, the Sun's Azimuth, and Topology

NASA Astrophysics Data System (ADS)

Giesige, C.; Nava, E.

2016-12-01

In the midst of a changing climate we have seen extremes in weather events: lightning, wildfires, hurricanes, tornadoes, and earthquakes. All of these ride on an imbalance of magnetic and electrical distribution about the earth including what goes on from the atmospheric and geophysic levels. There is relevance to the important role the sun plays in developing and feeding of the extreme weather events along with the sun's role helping to create a separation of charges on earth furthering climactic extremes. Focusing attention in North America and on how the sun, atmospheric and geophysic winds come together producing lightning events, there are connections between energy distribution in the environment, lightning caused wildfires, and extreme wildfire behavior. Lightning caused wildfires and extreme fire behavior have become enhanced with the changing climate conditions. Even with strong developments in wildfire science, there remains a lack in full understanding of connections that create a lightning caused wildfire event and lack of monitoring advancements in predicting extreme fire behavior. Several connections have been made in our research allowing us to connect multiple facets of the environment in regards to electric and magnetic influences on wildfires. Among them include: irradiance, winds, pressure systems, humidity, and topology. The connections can be made to develop better detection systems of wildfires, establish with more accuracy areas of highest risk for wildfire and extreme wildfire behavior, and prediction of wildfire behavior. A platform found within the environment can also lead to further understanding and monitoring of other extreme weather events in the future.

`Blame' Hawaii for Extreme Cold Air Outbreaks on the US West Coast?

NASA Astrophysics Data System (ADS)

Grotjahn, R.; Zhang, R.

2017-12-01

Short term extreme cold events punctuate the climate record. Though not always captured by monthly or seasonal means, they can have impacts lasting months. Extreme cold air outbreaks affecting the US West Coast are associated with a specific large scale meteorological pattern (LSMP). The LSMP has large meridional displacements of warm and cold air that create a ridge over and south of western Alaska, then a trough downstream moving with the cold air of the CAO, and finally another ridge over the southeastern US. These three features form in that order over several days leading up to the CAO onset. The warm advection creating the Alaskan ridge displaces cold air which is then advected southward along the North American west coast. Our recent work shows that both advections are driven by a lower level highly unusual high pressure center near the Gulf of Alaska. The cold air advection includes a continental interior portion (which sets up an offshore pressure gradient) and a portion off the west coast (air parcels high enough to be little modified before sinking over the US West Coast). In the mid to upper troposphere there are additional cyclonic centers to the south of the Alaskan ridge. Depending on the region compared, the LSMP has notable pattern correlation (up to 0.7) with the Pacific-North American teleconnection (PNA) negative phase pattern. (Others have shown a link between the PNA negative phase and unusual cold over northwestern North America on longer time scales. Here we find a higher frequency LSMP having centers offset from corresponding centers in the negative phase PNA loading pattern.) Even earlier before onset, we find a connection to a stream function structure straddling the equator that shares properties with slow moving equatorial Rossby waves; this pattern includes a trough near Hawaii that appears linked to the Alaskan ridge building that initiates the CAO. Hence, we arrive at our provocative title. All these features in the geopotential and stream function fields are highly significant from bootstrap statistics. The presentation will emphasize the time evolution of these significant features.

Abnormal viscoelastic behavior of side-chain liquid-crystal polymers

NASA Astrophysics Data System (ADS)

Gallani, J. L.; Hilliou, L.; Martinoty, P.; Keller, P.

1994-03-01

We show that, contrary to what is commonly believed, the isotropic phase of side-chain liquid-crystal polymers has viscoelastic properties which are totally different from those of ordinary flexible melt polymers. The results can be explained by the existence of a transient network created by the dynamic association of mesogenic groups belonging to different chains. The extremely high sensitivity of the compound to the state of the surfaces with which it is in contact offers us an unexpected method of studying surface states.

KSC-2009-2949

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a crane lifts the X-band radar from its transporter to move it onto the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2948

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a crane is moved into position to lift the X-band radar onto the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2952

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., technicians help install the X-band radar on the deck of the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2954

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., the crane is removed from the X-band radar after installation on the deck of the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2953

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., technicians complete installation of the X-band radar (right) on the deck of the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2951

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., technicians help place the X-band radar on the deck of the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

Apparatuses for prestressing rod-type specimens in torsion for in-situ passive fracture toughness testing in an extremely high-pressure environment of hydrogen

DOEpatents

Wang, Jy-an [Oak Ridge, TN; Liu, Ken C [Oak Ridge, TN; Feng, Zhili [Knoxville, TN

2012-05-15

An in-situ specimen fixture particularly adapted for prestressing rod-type SNTT-type specimens comprising a tube and end cap wherein the specimen is secured at one end to the tube, and at the opposite end to the end cap. The end cap is rotatable relative to the tube, and may be fixedly secured for creating a torsional force prestressing the specimen enclosed within the tube.

Gravitational Instabilities, Chondrule Formation, and the FU Orionis Phenomenon

NASA Astrophysics Data System (ADS)

Boley, Aaron C.; Durisen, Richard H.

2008-10-01

Using analytic arguments and numerical simulations, we examine whether chondrule formation and the FU Orionis phenomenon can be caused by the burstlike onset of gravitational instabilities (GIs) in dead zones. At least two scenarios for bursting dead zones can work, in principle. If the disk is on the verge of fragmentation, GI activation near r ~ 4-5 AU can produce chondrule-forming shocks, at least under extreme conditions. Mass fluxes are also high enough during the onset of GIs to suggest that the outburst is related to an FU Orionis phenomenon. This situation is demonstrated by numerical simulations. In contrast, as supported by analytic arguments, if the burst takes place close to r ~ 1 AU, then even low pitch angle spiral waves can create chondrule-producing shocks and outbursts. We also study the stability of the massive disks in our simulations against fragmentation and find that although disk evolution is sensitive to changes in opacity, the disks we study do not fragment, even at high resolution and even for extreme assumptions.

Helium (3) Rich Solar Flares

DOE R&D Accomplishments Database

Colgate, S. A.; Audouze, J.; Fowler, W. A.

1977-05-03

The extreme enrichment of {sup 3} He {sup 4} He greater than or equal to 1 in some solar flares as due to spallation and the subsequent confinement of the products in a high temperature, kT approx. = 200 keV, high density, n{sub e} approx. = 3 x 10{sup 15} cm {sup -3} plasma associated with the magnetic instability producing the flare is interpreted. The pinch or filament is a current of high energy protons that creates the spallation and maintains the temperature that produces the high energy x-ray spectrum and depletes other isotopes D, Li, Be, and B as observed. Finally the high temperature plasma is a uniquely efficient spallation target that is powered by the interaction of stellar convection and self generated magnetic field.

Interactions between social structure, demography, and transmission determine disease persistence in primates.

PubMed

Ryan, Sadie J; Jones, James H; Dobson, Andrew P

2013-01-01

Catastrophic declines in African great ape populations due to disease outbreaks have been reported in recent years, yet we rarely hear of similar disease impacts for the more solitary Asian great apes, or for smaller primates. We used an age-structured model of different primate social systems to illustrate that interactions between social structure and demography create 'dynamic constraints' on the pathogens that can establish and persist in primate host species with different social systems. We showed that this varies by disease transmission mode. Sexually transmitted infections (STIs) require high rates of transmissibility to persist within a primate population. In particular, for a unimale social system, STIs require extremely high rates of transmissibility for persistence, and remain at extremely low prevalence in small primates, but this is less constrained in longer-lived, larger-bodied primates. In contrast, aerosol transmitted infections (ATIs) spread and persist at high prevalence in medium and large primates with moderate transmissibility;, establishment and persistence in small-bodied primates require higher relative rates of transmissibility. Intragroup contact structure - the social network - creates different constraints for different transmission modes, and our model underscores the importance of intragroup contacts on infection prior to intergroup movement in a structured population. When alpha males dominate sexual encounters, the resulting disease transmission dynamics differ from when social interactions are dominated by mother-infant grooming events, for example. This has important repercussions for pathogen spread across populations. Our framework reveals essential social and demographic characteristics of primates that predispose them to different disease risks that will be important for disease management and conservation planning for protected primate populations.

Quantitative methods for stochastic high frequency spatio-temporal and non-linear analysis: Assessing health effects of exposure to extreme ambient temperature

NASA Astrophysics Data System (ADS)

Liss, Alexander

Extreme weather events, such as heat waves and cold spells, cause substantial excess mortality and morbidity in the vulnerable elderly population, and cost billions of dollars. The accurate and reliable assessment of adverse effects of extreme weather events on human health is crucial for environmental scientists, economists, and public health officials to ensure proper protection of vulnerable populations and efficient allocation of scarce resources. However, the methodology for the analysis of large national databases is yet to be developed. The overarching objective of this dissertation is to examine the effect of extreme weather on the elderly population of the Conterminous US (ConUS) with respect to seasonality in temperature in different climatic regions by utilizing heterogeneous high frequency and spatio-temporal resolution data. To achieve these goals the author: 1) incorporated dissimilar stochastic high frequency big data streams and distinct data types into the integrated data base for use in analytical and decision support frameworks; 2) created an automated climate regionalization system based on remote sensing and machine learning to define climate regions for the Conterminous US; 3) systematically surveyed the current state of the art and identified existing gaps in the scientific knowledge; 4) assessed the dose-response relationship of exposure to temperature extremes on human health in relatively homogeneous climate regions using different statistical models, such as parametric and non-parametric, contemporaneous and asynchronous, applied to the same data; 5) assessed seasonal peak timing and synchronization delay of the exposure and the disease within the framework of contemporaneous high frequency harmonic time series analysis and modification of the effect by the regional climate; 6) modeled using hyperbolic functional form non-linear properties of the effect of exposure to extreme temperature on human health. The proposed climate regionalization method algorithmically forms eight climatically homogeneous regions for Conterminous US from satellite Remote Sensing inputs. The relative risk of hospitalizations due to extreme ambient temperature varied across climatic regions. Difference in regional hospitalization rates suggests presence of an adaptation effect to a prevailing climate. In various climatic regions the hospitalizations peaked earlier than the peak of exposure. This suggests disproportionally high impact of extreme weather events, such as cold spells or heat waves when they occur early in the season. These findings provide an insight into the use of high frequency disjoint data sets for the assessment of the magnitude, timing, synchronization and non-linear properties of adverse health consequences due to exposure to extreme weather events to the elderly in defined climatic regions. These findings assist in the creation of decision support frameworks targeting preventions and adaptation strategies such as improving infrastructure, providing energy assistance, education and early warning notifications for the vulnerable population. This dissertation offers a number of methodological innovations for the assessment of the high frequency spatio-temporal and non-linear impacts of extreme weather events on human health. These innovations help to ensure an improved protection of the elderly population, aid policy makers in the development of efficient disaster prevention strategies, and facilitate more efficient allocation of scarce resources.

Pulsed hybrid field emitter

DOEpatents

Sampayan, Stephen E.

1998-01-01

A hybrid emitter exploits the electric field created by a rapidly depoled ferroelectric material. Combining the emission properties of a planar thin film diamond emitter with a ferroelectric alleviates the present technological problems associated with both types of emitters and provides a robust, extremely long life, high current density cathode of the type required by emerging microwave power generation, accelerator technology and display applications. This new hybrid emitter is easy to fabricate and not susceptible to the same failures which plague microstructure field emitter technology. Local electrode geometries and electric field are determined independently from those for optimum transport and brightness preservation. Due to the large amount of surface charge created on the ferroelectric, the emitted electrons have significant energy, thus eliminating the requirement for specialized phosphors in emissive flat-panel displays.

Pulsed hybrid field emitter

DOEpatents

Sampayan, S.E.

1998-03-03

A hybrid emitter exploits the electric field created by a rapidly depoled ferroelectric material. Combining the emission properties of a planar thin film diamond emitter with a ferroelectric alleviates the present technological problems associated with both types of emitters and provides a robust, extremely long life, high current density cathode of the type required by emerging microwave power generation, accelerator technology and display applications. This new hybrid emitter is easy to fabricate and not susceptible to the same failures which plague microstructure field emitter technology. Local electrode geometries and electric field are determined independently from those for optimum transport and brightness preservation. Due to the large amount of surface charge created on the ferroelectric, the emitted electrons have significant energy, thus eliminating the requirement for specialized phosphors in emissive flat-panel displays. 11 figs.

Social selection is a powerful explanation for prosociality.

PubMed

Nesse, Randolph M

2016-01-01

Cultural group selection helps explain human cooperation, but social selection offers a complementary, more powerful explanation. Just as sexual selection shapes extreme traits that increase matings, social selection shapes extreme traits that make individuals preferred social partners. Self-interested partner choices create strong and possibly runaway selection for prosocial traits, without requiring group selection, kin selection, or reciprocity.

Creating "Invited" Spaces for Counter-Radicalization and Counter-Extremism Education

ERIC Educational Resources Information Center

Arshad-Ayaz, Adeela; Naseem, M. Ayaz

2017-01-01

In this article we present an articulation of how "invited spaces" can foster inclusive and authentic participation and public discourse on issues related to extremism and radicalization. Conversations on these issues that are of crucial importance to the general public are usually held in closed spaces or in spaces that are set up by…

Extreme flooding in the West African cities of Dakar and Ouagadougou - atmospheric dynamics and implications for flood risk assessments

NASA Astrophysics Data System (ADS)

Engel, Thomas; Fink, Andreas; Knippertz, Peter

2017-04-01

In this study, two extreme, high-impact events of heavy rainfall and severe floods in West African urban areas (Ouagadougou in 2009, Dakar in 2012) are investigated in terms of their atmospheric causes and statistical return periods. In terms of the synoptic-convective dynamics, the Ouagadougou case is truly exceptional. A succession of two strong and temporarily slow-moving African Easterly Waves (AEWs) caused record-breaking values of tropospheric moisture and low-level relative vorticity, thereby providing the synoptic forcing for the nighttime genesis of Mesoscale Convective Systems (MCSs). Ouagadougou was hit by two successive MCSs, the latter being possible due to the rotation and swift moisture refuelling by the strong convergence in the AEW-related vortex. It is speculated that this case may allow a glimpse of a new type of extreme Sahelian rainstorms. Similarly to the Ouagadougou case, an AEW was instrumental in the overnight development of an MCSs to the east of Dakar, but neither the AEW vortex nor the tropospheric moisture content was as exceptional as in the Ouagadougou case. The Return Value (RV) analysis suggests that TRMM 3B42 data appears to be suitable to estimate centennial RVs using the "peak-over-threshold" approach with a GPD fit, though the good performance might be a result of errors in estimating extreme rainfall over the arid Sahel. On the contrary PERSIANN-CDR is inappropriate for this purpose, despite having a twice as long observational period. The Ouagadougou event also shows that highly unusual dynamical developments can create extreme situations well outside of any RV estimates from century-long daily rainfall observations.

Numerical investigation of freak waves

NASA Astrophysics Data System (ADS)

Chalikov, D.

2009-04-01

Paper describes the results of more than 4,000 long-term (up to thousands of peak-wave periods) numerical simulations of nonlinear gravity surface waves performed for investigation of properties and estimation of statistics of extreme (‘freak') waves. The method of solution of 2-D potential wave's equations based on conformal mapping is applied to the simulation of wave behavior assigned by different initial conditions, defined by JONSWAP and Pierson-Moskowitz spectra. It is shown that nonlinear wave evolution sometimes results in appearance of very big waves. The shape of freak waves varies within a wide range: some of them are sharp-crested, others are asymmetric, with a strong forward inclination. Some of them can be very big, but not steep enough to create dangerous conditions for vessels (but not for fixed objects). Initial generation of extreme waves can occur merely as a result of group effects, but in some cases the largest wave suddenly starts to grow. The growth is followed sometimes by strong concentration of wave energy around a peak vertical. It is taking place in the course of a few peak wave periods. The process starts with an individual wave in a physical space without significant exchange of energy with surrounding waves. Sometimes, a crest-to-trough wave height can be as large as nearly three significant wave heights. On the average, only one third of all freak waves come to breaking, creating extreme conditions, however, if a wave height approaches the value of three significant wave heights, all of the freak waves break. The most surprising result was discovery that probability of non-dimensional freak waves (normalized by significant wave height) is actually independent of density of wave energy. It does not mean that statistics of extreme waves does not depend on wave energy. It just proves that normalization of wave heights by significant wave height is so effective, that statistics of non-dimensional extreme waves tends to be independent of wave energy. It is naive to expect that high order moments such as skewness and kurtosis can serve as predictors or even indicators of freak waves. Firstly, the above characteristics cannot be calculated with the use of spectrum usually determined with low accuracy. Such calculations are definitely unstable to a slight perturbation of spectrum. Secondly, even if spectrum is determined with high accuracy (for example calculated with the use of exact model), the high order moments cannot serve as the predictors, since they change synchronically with variations of extreme wave heights. Appearance of freak waves occurs simultaneously with increase of the local kurtosis, hence, kurtosis is simply a passive indicator of the same local geometrical properties of a wave field. This effect disappears completely, if spectrum is calculated over a very wide ensemble of waves. In this case existence of a freak wave is just disguised by other, non freak waves. Thirdly, all high order moments are dependant of spectral presentation - they increase with increasing of spectral resolution and cut-frequency. Statistics of non-dimensional waves as well as emergence of extreme waves is the innate property of a nonlinear wave field. Probability function for steep waves has been constructed. Such type function can be used for development of operational forecast of freak waves based on a standard forecast provided by the 3-d generation wave prediction model (WAVEWATCH or WAM).

Microorganisms in desert rocks: the edge of life on Earth.

PubMed

Wierzchos, Jacek; de los Ríos, Asunción; Ascaso, Carmen

2012-12-01

This article reviews current knowledge on microbial communities inhabiting endolithic habitats in the arid and hyper-arid regions of our planet. In these extremely dry environments, the most common survival strategy is to colonize the interiors of rocks. This habitat provides thermal buffering, physical stability, and protection against incident UV radiation, excessive photosynthetically active radiation, and freeze-thaw events. Above all, through water retention in the rocks' network of pores and fissures, moisture is made available. Some authors have argued that dry environments pose the most extreme set of conditions faced by microorganisms. Microbial cells need to withstand the biochemical stresses created by the lack of water, along with temperature fluctuations and/or high salinity. In this review, we also address the variety of ways in which microorganisms deal with the lack of moisture in hyper-arid environments and point out the diversity of microorganisms that are able to cope with only the scarcest presence of water. Finally, we discuss the important clues to the history of life on Earth, and perhaps other places in our solar system, that have emerged from the study of extreme microbial ecosystems.

Extreme creep resistance in a microstructurally stable nanocrystalline alloy

NASA Astrophysics Data System (ADS)

Darling, K. A.; Rajagopalan, M.; Komarasamy, M.; Bhatia, M. A.; Hornbuckle, B. C.; Mishra, R. S.; Solanki, K. N.

2016-09-01

Nanocrystalline metals, with a mean grain size of less than 100 nanometres, have greater room-temperature strength than their coarse-grained equivalents, in part owing to a large reduction in grain size. However, this high strength generally comes with substantial losses in other mechanical properties, such as creep resistance, which limits their practical utility; for example, creep rates in nanocrystalline copper are about four orders of magnitude higher than those in typical coarse-grained copper. The degradation of creep resistance in nanocrystalline materials is in part due to an increase in the volume fraction of grain boundaries, which lack long-range crystalline order and lead to processes such as diffusional creep, sliding and rotation. Here we show that nanocrystalline copper-tantalum alloys possess an unprecedented combination of properties: high strength combined with extremely high-temperature creep resistance, while maintaining mechanical and thermal stability. Precursory work on this family of immiscible alloys has previously highlighted their thermo-mechanical stability and strength, which has motivated their study under more extreme conditions, such as creep. We find a steady-state creep rate of less than 10-6 per second—six to eight orders of magnitude lower than most nanocrystalline metals—at various temperatures between 0.5 and 0.64 times the melting temperature of the matrix (1,356 kelvin) under an applied stress ranging from 0.85 per cent to 1.2 per cent of the shear modulus. The unusual combination of properties in our nanocrystalline alloy is achieved via a processing route that creates distinct nanoclusters of atoms that pin grain boundaries within the alloy. This pinning improves the kinetic stability of the grains by increasing the energy barrier for grain-boundary sliding and rotation and by inhibiting grain coarsening, under extremely long-term creep conditions. Our processing approach should enable the development of microstructurally stable structural alloys with high strength and creep resistance for various high-temperature applications, including in the aerospace, naval, civilian infrastructure and energy sectors.

Directed evolution of an extremely stable fluorescent protein.

PubMed

Kiss, Csaba; Temirov, Jamshid; Chasteen, Leslie; Waldo, Geoffrey S; Bradbury, Andrew R M

2009-05-01

In this paper we describe the evolution of eCGP123, an extremely stable green fluorescent protein based on a previously described fluorescent protein created by consensus engineering (CGP: consensus green protein). eCGP123 could not be denatured by a standard thermal melt, preserved almost full fluorescence after overnight incubation at 80 degrees C and possessed a free energy of denaturation of 12.4 kcal/mol. It was created from CGP by a recursive process involving the sequential introduction of three destabilizing heterologous inserts, evolution to overcome the destabilization and finally 'removal' of the destabilizing insert by gene synthesis. We believe that this approach may be generally applicable to the stabilization of other proteins.

Exergaming: Syncing Physical Activity and Learning

ERIC Educational Resources Information Center

Hicks, Lisa; Higgins, John

2010-01-01

This article discusses exergaming, a groundbreaking type of video game which is creating a revolution in physical education. Exergaming combines physical activity and video gaming to create an enjoyable and appealing way for students to be physically active. An extremely popular choice in this genre is the music video/dance rhythm game (MVDG). One…

High-Order Dielectric Metasurfaces for High-Efficiency Polarization Beam Splitters and Optical Vortex Generators

NASA Astrophysics Data System (ADS)

Guo, Zhongyi; Zhu, Lie; Guo, Kai; Shen, Fei; Yin, Zhiping

2017-08-01

In this paper, a high-order dielectric metasurface based on silicon nanobrick array is proposed and investigated. By controlling the length and width of the nanobricks, the metasurfaces could supply two different incremental transmission phases for the X-linear-polarized (XLP) and Y-linear-polarized (YLP) light with extremely high efficiency over 88%. Based on the designed metasurface, two polarization beam splitters working in high-order diffraction modes have been designed successfully, which demonstrated a high transmitted efficiency. In addition, we have also designed two vortex-beam generators working in high-order diffraction modes to create vortex beams with the topological charges of 2 and 3. The employment of dielectric metasurfaces operating in high-order diffraction modes could pave the way for a variety of new ultra-efficient optical devices.

Self-Assembled Array of Tethered Manganese Oxide Nanoparticles for the Next Generation of Energy Storage

DOE PAGES

Stevens, Tyler E.; Pearce, Charles J.; Whitten, Caleah N.; ...

2017-03-13

There are many challenges to overcome in order to create reliable electrochemical energy storage devices with not only high energy but also high power densities. Gaps exist in both battery and supercapacitor technologies, with neither one satisfying the need for both large power and energy densities in a single device. We report a process to create a self-assembled array of electrochemically active nanoparticles bound directly to a current collector using extremely short (2 nm or less) conductive tethers, in order to begin addressing these challenges (and others). The tethered array of nanoparticles, MnO in this case, bound directly to amore » gold current collector via short conducting linkages eliminates the need for fillers, resulting in a material which achieves 99.9% active material by mass (excluding the current collector). Our strategy is expected to be both scalable as well as effective for alternative tethers and metal oxide nanoparticles.« less

Low temperature plasmas induced in SF6 by extreme ultraviolet (EUV) pulses

NASA Astrophysics Data System (ADS)

Bartnik, A.; Skrzeczanowski, W.; Czwartos, J.; Kostecki, J.; Fiedorowicz, H.; Wachulak, P.; Fok, T.

2018-06-01

In this work, a comparative study of extreme ultraviolet (EUV) induced low temperature SF6-based plasmas, created using two different irradiation systems, was performed. Both systems utilized laser-produced plasma (LPP) EUV sources. The essential difference between the systems concerned the formation of the driving EUV beam. The first one contained an efficient ellipsoidal EUV collector allowing for focusing of the EUV radiation at a large distance from the LPP source. The spectrum of focused radiation was limited to the long-wavelength part of the total LPP emission, λ > 8 nm, due to the reflective properties of the collector. The second system did not contain any EUV collector. The gas to be ionized was injected in the vicinity of the LPP, at a distance of the order of 10 mm. In both systems, energies of the driving photons were high enough for dissociative ionization of the SF6 molecules and ionization of atoms or even singly charged ions. Plasmas, created due to these processes, were investigated by spectral measurements in the EUV, ultraviolet (UV), and visible (VIS) spectral ranges. These low temperature plasmas were employed for preliminary experiments concerning surface treatment. The formation of pronounced nanostructures on the silicon surface after plasma treatment was demonstrated.

Reversible creation of nanostructures between identical or different species of materials

NASA Astrophysics Data System (ADS)

Jang, Hyun-Ik; Ko, Sungho; Park, Junyong; Lee, Dong-Eon; Jeon, Seokwoo; Ahn, Chi Won; Yoo, Kwang Soo; Park, Jae Hong

2012-07-01

In this study, accurate nanostructures with various aspect ratios are created on several types of material. This work is highly applicable to the energy, optical, and nano-bio fields, for example. A silicon (Si) nano-mold is preserved using the method described, and target nanostructures are replicated reversibly and unlimitedly to or from various hard and soft materials. It is also verified that various materials can be applied to the substrates. The results confirm that the target nanostructures are successfully created in precise straight line structures and circle structures with various aspect ratios, including extremely high aspect ratios of 1:18. It is suggested that the optimal replicating and demolding process of nanostructures with high aspect ratios, which are the most problematic, could be controlled by means of the surface energy between the functional materials. Relevant numerical and analytical studies are also performed. It is possible to expand the applicability of the nanostructured mold by adopting various backing materials, including rounded substrates. The scope of the applications is extended further by transferring the nanostructures between different species of materials including metallic materials as well as identical species.

Using SDO Data in the Classroom to Do Real Science -- A Community College Laboratory Investigation

NASA Astrophysics Data System (ADS)

Dave, T. A.; Hildreth, S.; Lee, S.; Scherrer, D. K.

2013-12-01

The incredible accessibility of extremely high spatial and temporal resolution data from the Solar Dynamics Observatory creates an opportunity for students to do almost real-time investigation in an Astronomy Lab. We are developing a short series of laboratory exercises using SDO data, targeted for Community College students in an introductory lab class, extendable to high school and university students. The labs initially lead students to explore what SDO can do, online, through existing SDO video clips taken on specific dates. Students then investigate solar events using the Heliophysics Events Knowledgebase (HEK), and make their own online movies of events, to discuss and share with classmates. Finally, students can investigate specific events and areas, selecting specific dates, locations, wavelength regions, and time cadences to create and gather their own SDO datasets for more detailed investigation. In exploring the Sun using actual data, students actually do real science. We are in the process of beta testing the sequence of labs, and are seeking interested community college, university, and high school astronomy lab teachers who might consider trying the labs themselves.

FastID: Extremely Fast Forensic DNA Comparisons

DTIC Science & Technology

2017-05-19

FastID: Extremely Fast Forensic DNA Comparisons Darrell O. Ricke, PhD Bioengineering Systems & Technologies Massachusetts Institute of...Technology Lincoln Laboratory Lexington, MA USA Darrell.Ricke@ll.mit.edu Abstract—Rapid analysis of DNA forensic samples can have a critical impact on...time sensitive investigations. Analysis of forensic DNA samples by massively parallel sequencing is creating the next gold standard for DNA

The extreme ultraviolet explorer archive

NASA Astrophysics Data System (ADS)

Polomski, E.; Drake, J. J.; Dobson, C.; Christian, C.

1993-09-01

The Extreme Ultrviolet Explorer (EUVE) public archive was created to handle the storage, maintenance, and distribution of EUVE data and ancillary documentation, information, and software. Access to the archive became available to the public on July 17, 1992, only 40 days after the launch of the EUVE satellite. A brief overview of the archive's contents and the various methods of access will be described.

Space Suit Technologies Protect Deep-Sea Divers

NASA Technical Reports Server (NTRS)

2008-01-01

Working on NASA missions allows engineers and scientists to hone their skills. Creating devices for the high-stress rigors of space travel pushes designers to their limits, and the results often far exceed the original concepts. The technologies developed for the extreme environment of space are often applicable here on Earth. Some of these NASA technologies, for example, have been applied to the breathing apparatuses worn by firefighters, the fire-resistant suits worn by racecar crews, and, most recently, the deep-sea gear worn by U.S. Navy divers.

KSC-2009-2955

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a container is prepared for transfer to the U.S. Army landing craft utility ship Brandy Station. Inside is the control center for the X-band radar installed on the deck of the ship. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2959

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., workers prepare the container that holds the control center for the X-band radar, at right, installed on the U.S. Army landing craft utility ship Brandy Station. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

FINITE ELEMENT MODEL FOR TIDAL AND RESIDUAL CIRCULATION.

USGS Publications Warehouse

Walters, Roy A.

1986-01-01

Harmonic decomposition is applied to the shallow water equations, thereby creating a system of equations for the amplitude of the various tidal constituents and for the residual motions. The resulting equations are elliptic in nature, are well posed and in practice are shown to be numerically well-behaved. There are a number of strategies for choosing elements: the two extremes are to use a few high-order elements with continuous derivatives, or to use a large number of simpler linear elements. In this paper simple linear elements are used and prove effective.

One-per-mil tumescent technique for upper extremity surgeries: broadening the indication.

PubMed

Prasetyono, Theddeus O H; Biben, Johannes A

2014-01-01

We studied the effect of 1:1,000,000 epinephrine concentration (1 per mil) to attain a bloodless operative field in hand and upper extremity surgery and to explore its effectiveness and safety profile. This retrospective observational study enrolled 45 consecutive patients with 63 operative fields consisting of various hand and upper extremity problems. One-per-mil solution was injected into the operative field with tumescent technique to create a bloodless operating field without tourniquet. The solution was formulated by adding a 1:1,000,000 concentration of epinephrine and 100 mg of lidocaine into saline solution to form 50 mL of tumescent solution. Observation was performed on the clarity of the operative field, which we described as totally bloodless, minimal bleeding, acceptable bleeding, or bloody. The volume of tumescent solution injected, duration of surgery, and surgical outcome were also reviewed. The tumescent technique with 1-per-mil solution achieved 29% totally bloodless, 48% minimal bleeding, 22% acceptable bleeding, and 2% bloody operative fields in cases that included burn contracture and congenital hand and upper extremity surgeries. One-per-mil tumescent solution created a clear operative field in hand and upper extremity surgery. It proved safe and effective for a wide range of indications. Therapeutic IV. Copyright © 2014 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

From daily to sub-daily time steps - Creating a high temporal and spatial resolution climate reference data set for hydrological modeling and bias-correction of RCM data

NASA Astrophysics Data System (ADS)

Willkofer, Florian; Wood, Raul R.; Schmid, Josef; von Trentini, Fabian; Ludwig, Ralf

2016-04-01

The ClimEx project (Climate change and hydrological extreme events - risks and perspectives for water management in Bavaria and Québec) focuses on the effects of climate change on hydro-meteorological extreme events and their implications for water management in Bavaria and Québec. It builds on the conjoint analysis of a large ensemble of the CRCM5, driven by 50 members of the CanESM2, and the latest information provided through the CORDEX-initiative, to better assess the influence of natural climate variability and climatic change on the dynamics of extreme events. A critical point in the entire project is the preparation of a meteorological reference dataset with the required temporal (1-6h) and spatial (500m) resolution to be able to better evaluate hydrological extreme events in mesoscale river basins. For Bavaria a first reference data set (daily, 1km) used for bias-correction of RCM data was created by combining raster based data (E-OBS [1], HYRAS [2], MARS [3]) and interpolated station data using the meteorological interpolation schemes of the hydrological model WaSiM [4]. Apart from the coarse temporal and spatial resolution, this mosaic of different data sources is considered rather inconsistent and hence, not applicable for modeling of hydrological extreme events. Thus, the objective is to create a dataset with hourly data of temperature, precipitation, radiation, relative humidity and wind speed, which is then used for bias-correction of the RCM data being used as driver for hydrological modeling in the river basins. Therefore, daily data is disaggregated to hourly time steps using the 'Method of fragments' approach [5], based on available training stations. The disaggregation chooses fragments of daily values from observed hourly datasets, based on similarities in magnitude and behavior of previous and subsequent events. The choice of a certain reference station (hourly data, provision of fragments) for disaggregating daily station data (application of fragments) is crucial and several methods will be tested to achieve a profound spatial interpolation. This entire methodology shall be applicable for existing or newly developed datasets. References [1] Haylock, M.R., N. Hofstra, A.M.G. Klein Tank, E.J. Klok, P.D. Jones and M. New. A European daily high-resolution gridded dataset of surface temperature and precipitation. J. Geophys. Res (Atmospheres) (2008), 113, D20119, doi:10.1029/2008JD10201. [2] Rauthe, M., Steiner, H., Riediger, U., Mazurkiewicz, A. and A. Gratzki. A Central European precipitation climatology - Part I: Generation and validation of a high-resolution gridded daily data set (HYRAS). Meteorologische Zeitschrift (2013), 22/3, p.238-256. [3] MARS-AGRI4CAST. AGRI4CAST Interpolated Meteorological Data. http://mars.jrc.ec.europa.eu/mars/ About-us/AGRI4CAST/Data-distribution/AGRI4CAST-Interpolated-Meteorological-Data. 2007, last accessed May 10th, 2013. [4] Schulla, J. Model Description WaSiM - Water balance Simulation Model. 2015, available at: http://wasim.ch/en/products/wasim_description.htm. [5] Sharma, A. and S. Srikanthan. Continuous Rainfall Simulation: A Nonparametric Alternative. 30th Hydrology and Water Resources Symposium, Launceston, Tasmania, 4-7 December, 2006.

The impact of climate change on the epidemiology and control of Rift Valley fever.

PubMed

Martin, V; Chevalier, V; Ceccato, P; Anyamba, A; De Simone, L; Lubroth, J; de La Rocque, S; Domenech, J

2008-08-01

Climate change is likely to change the frequency of extreme weather events, such as tropical cyclones, floods, droughts and hurricanes, and may destabilise and weaken the ecosystem services upon which human society depends. Climate change is also expected to affect animal, human and plant health via indirect pathways: it is likely that the geography of infectious diseases and pests will be altered, including the distribution of vector-borne diseases, such as Rift Valley fever, yellow fever, malaria and dengue, which are highly sensitive to climatic conditions. Extreme weather events might then create the necessary conditions for Rift Valley fever to expand its geographical range northwards and cross the Mediterranean and Arabian seas, with an unexpected impact on the animal and human health of newly affected countries. Strengthening global, regional and national early warning systems is crucial, as are co-ordinated research programmes and subsequent prevention and intervention measures.

Performance of the Micropower Voltage Reference ADR3430 Under Extreme Temperatures

NASA Technical Reports Server (NTRS)

Patterson, Richard L.; Hammoud, Ahmad

2011-01-01

Electronic systems designed for use in space exploration systems are expected to be exposed to harsh temperatures. For example, operation at cryogenic temperatures is anticipated in space missions such as polar craters of the moon (-223 C), James Webb Space Telescope (-236 C), Mars (-140 C), Europa (-223 C), Titan (-178 C), and other deep space probes away from the sun. Similarly, rovers and landers on the lunar surface, and deep space probes intended for the exploration of Venus are expected to encounter high temperature extremes. Electronics capable of operation under extreme temperatures would not only meet the requirements of future spacebased systems, but would also contribute to enhancing efficiency and improving reliability of these systems through the elimination of the thermal control elements that present electronics need for proper operation under the harsh environment of space. In this work, the performance of a micropower, high accuracy voltage reference was evaluated over a wide temperature range. The Analog Devices ADR3430 chip uses a patented voltage reference architecture to achieve high accuracy, low temperature coefficient, and low noise in a CMOS process [1]. The device combines two voltages of opposite temperature coefficients to create an output voltage that is almost independent of ambient temperature. It is rated for the industrial temperature range of -40 C to +125 C, and is ideal for use in low power precision data acquisition systems and in battery-powered devices. Table 1 shows some of the manufacturer s device specifications.

Collisions of Terrestrial Worlds: The Occurrence of Extreme Mid-infrared Excesses around Low-mass Field Stars

NASA Astrophysics Data System (ADS)

Theissen, Christopher A.; West, Andrew A.

2017-04-01

We present the results of an investigation into the occurrence and properties (stellar age and mass trends) of low-mass field stars exhibiting extreme mid-infrared (MIR) excesses ({L}{IR}/{L}* ≳ 0.01). Stars for the analysis were initially selected from the Motion Verified Red Stars (MoVeRS) catalog of photometric stars with Sloan Digital Sky Survey, 2MASS, and WISE photometry and significant proper motions. We identify 584 stars exhibiting extreme MIR excesses, selected based on an empirical relationship for main-sequence W1-W3 colors. For a small subset of the sample, we show, using spectroscopic tracers of stellar age (Hα and Li I) and luminosity class, that the parent sample is most likely comprised of field dwarfs (≳ 1 Gyr). We also develop the Low-mass Kinematics (LoKi) galactic model to estimate the completeness of the extreme MIR excess sample. Using Galactic height as a proxy for stellar age, the completeness-corrected analysis indicates a distinct age dependence for field stars exhibiting extreme MIR excesses. We also find a trend with stellar mass (using r - z color as a proxy). Our findings are consistent with the detected extreme MIR excesses originating from dust created in a short-lived collisional cascade (≲100,000 years) during a giant impact between two large planetismals or terrestrial planets. These stars with extreme MIR excesses also provide support for planetary collisions being the dominant mechanism in creating the observed Kepler dichotomy (the need for more than a single mode, typically two, to explain the variety of planetary system architectures Kepler has observed), rather than different formation mechanisms.

Extremely high-definition full-parallax computer-generated hologram created by the polygon-based method.

PubMed

Matsushima, Kyoji; Nakahara, Sumio

2009-12-01

A large-scale full-parallax computer-generated hologram (CGH) with four billion (2(16) x 2(16)) pixels is created to reconstruct a fine true 3D image of a scene, with occlusions. The polygon-based method numerically generates the object field of a surface object, whose shape is provided by a set of vertex data of polygonal facets, while the silhouette method makes it possible to reconstruct the occluded scene. A novel technique using the segmented frame buffer is presented for handling and propagating large wave fields even in the case where the whole wave field cannot be stored in memory. We demonstrate that the full-parallax CGH, calculated by the proposed method and fabricated by a laser lithography system, reconstructs a fine 3D image accompanied by a strong sensation of depth.

Flip the tip: an automated, high quality, cost-effective patch clamp screen.

PubMed

Lepple-Wienhues, Albrecht; Ferlinz, Klaus; Seeger, Achim; Schäfer, Arvid

2003-01-01

The race for creating an automated patch clamp has begun. Here, we present a novel technology to produce true gigaseals and whole cell preparations at a high rate. Suspended cells are flushed toward the tip of glass micropipettes. Seal, whole-cell break-in, and pipette/liquid handling are fully automated. Extremely stable seals and access resistance guarantee high recording quality. Data obtained from different cell types sealed inside pipettes show long-term stability, voltage clamp and seal quality, as well as block by compounds in the pM range. A flexible array of independent electrode positions minimizes consumables consumption at maximal throughput. Pulled micropipettes guarantee a proven gigaseal substrate with ultra clean and smooth surface at low cost.

Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Close, Devin W.; Paul, Craig Don; Langan, Patricia S.

In this paper, we describe the engineering and X-ray crystal structure of Thermal Green Protein (TGP), an extremely stable, highly soluble, non-aggregating green fluorescent protein. TGP is a soluble variant of the fluorescent protein eCGP123, which despite being highly stable, has proven to be aggregation-prone. The X-ray crystal structure of eCGP123, also determined within the context of this paper, was used to carry out rational surface engineering to improve its solubility, leading to TGP. The approach involved simultaneously eliminating crystal lattice contacts while increasing the overall negative charge of the protein. Despite intentional disruption of lattice contacts and introduction ofmore » high entropy glutamate side chains, TGP crystallized readily in a number of different conditions and the X-ray crystal structure of TGP was determined to 1.9 Å resolution. The structural reasons for the enhanced stability of TGP and eCGP123 are discussed. We demonstrate the utility of using TGP as a fusion partner in various assays and significantly, in amyloid assays in which the standard fluorescent protein, EGFP, is undesirable because of aberrant oligomerization.« less

Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering

DOE PAGES

Close, Devin W.; Paul, Craig Don; Langan, Patricia S.; ...

2015-05-08

In this paper, we describe the engineering and X-ray crystal structure of Thermal Green Protein (TGP), an extremely stable, highly soluble, non-aggregating green fluorescent protein. TGP is a soluble variant of the fluorescent protein eCGP123, which despite being highly stable, has proven to be aggregation-prone. The X-ray crystal structure of eCGP123, also determined within the context of this paper, was used to carry out rational surface engineering to improve its solubility, leading to TGP. The approach involved simultaneously eliminating crystal lattice contacts while increasing the overall negative charge of the protein. Despite intentional disruption of lattice contacts and introduction ofmore » high entropy glutamate side chains, TGP crystallized readily in a number of different conditions and the X-ray crystal structure of TGP was determined to 1.9 Å resolution. The structural reasons for the enhanced stability of TGP and eCGP123 are discussed. We demonstrate the utility of using TGP as a fusion partner in various assays and significantly, in amyloid assays in which the standard fluorescent protein, EGFP, is undesirable because of aberrant oligomerization.« less

Effects of Aging and Environmental Conditions on Ammunition/Explosives Storage Magazines - Paper 2

DTIC Science & Technology

2010-07-01

characterized as destructive. The destructive category is apparently limited to reactions with impure dolomitic aggregates and are a result of either...extreme pressures that eventually overcome the tensile strength of the structure. These pressures will cause spalling, map cracking, discoloration, or...fill with this gel and expand to create extreme tensile pressures . These pressures cause micro-scale cracking and eventually develop into

Developing a Framework for Seamless Prediction of Sub-Seasonal to Seasonal Extreme Precipitation Events in the United States.

NASA Astrophysics Data System (ADS)

Rosendahl, D. H.; Ćwik, P.; Martin, E. R.; Basara, J. B.; Brooks, H. E.; Furtado, J. C.; Homeyer, C. R.; Lazrus, H.; Mcpherson, R. A.; Mullens, E.; Richman, M. B.; Robinson-Cook, A.

2017-12-01

Extreme precipitation events cause significant damage to homes, businesses, infrastructure, and agriculture, as well as many injures and fatalities as a result of fast-moving water or waterborne diseases. In the USA, these natural hazard events claimed the lives of more than 300 people during 2015 - 2016 alone, with total damage reaching $24.4 billion. Prior studies of extreme precipitation events have focused on the sub-daily to sub-weekly timeframes. However, many decisions for planning, preparing and resilience-building require sub-seasonal to seasonal timeframes (S2S; 14 to 90 days), but adequate forecasting tools for prediction do not exist. Therefore, the goal of this newly funded project is an enhancement in understanding of the large-scale forcing and dynamics of S2S extreme precipitation events in the United States, and improved capability for modeling and predicting such events. Here, we describe the project goals, objectives, and research activities that will take place over the next 5 years. In this project, a unique team of scientists and stakeholders will identify and understand weather and climate processes connected with the prediction of S2S extreme precipitation events by answering these research questions: 1) What are the synoptic patterns associated with, and characteristic of, S2S extreme precipitation evens in the contiguous U.S.? 2) What role, if any, do large-scale modes of climate variability play in modulating these events? 3) How predictable are S2S extreme precipitation events across temporal scales? 4) How do we create an informative prediction of S2S extreme precipitation events for policymaking and planing? This project will use observational data, high-resolution radar composites, dynamical climate models and workshops that engage stakeholders (water resource managers, emergency managers and tribal environmental professionals) in co-production of knowledge. The overarching result of this project will be predictive models to reduce of the societal and economic impacts of extreme precipitation events. Another outcome will include statistical and co-production frameworks, which could be applied across other meteorological extremes, all time scales and in other parts of the world to increase resilience to extreme meteorological events.

Journeys through the valley of death: multimethod psychological assessment and personality transformation in long-term psychotherapy.

PubMed

Finn, Stephen E

2011-03-01

The Psychodynamic Diagnostic Manual (PDM Task Force, 2006) is based on the assumption that an in-depth understanding of clients' underlying emotional, personality, and interpersonal patterns will facilitate their treatment. In this article I show how such an understanding can be achieved through multimethod psychological assessment, and how useful such information can be in long-term psychotherapy with high-achieving, successful clients who struggle with forming and maintaining intimate relationships. Such treatments are extremely difficult, because when these clients attach to their psychotherapists, many of them temporarily become more symptomatic. I illustrate these points with a detailed account of my long-term therapy with a resilient but highly traumatized young man. Repeated use of the Minnesota Multiphasic Personality Disorder-2 (MMPI-2; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) and Rorschach with my client helped guide us in our work, and also helped create an important therapeutic "opening" into the underlying traumatic material. This and other experiences have convinced me that it is extremely useful for psychologists to have training in both assessment and psychotherapy.

Polarization-selective optical resonance with extremely narrow linewidth in Si dimers array for application in ultra-sensitive refractive sensing

NASA Astrophysics Data System (ADS)

Fu, Dong; Zhang, Zuyin; Li, Jian; Wu, Haoyue; Wang, Wenbo; Wei, Xin

2017-05-01

By exploiting the radiative coupling between the electromagnetic field scattered by individual Si dimer and the collective wave diffracted (Rayleigh Anomalies) in the plane of Si dimers array, optical resonance with extremely narrow linewidth is achieved, accompanied with dramatic enhancement of electric field in the gap of the dimer. We analyze the optical properties of Si dimers array by decomposing it into three fundamental sub-systems. Theoretical investigation employing the coupled dipole approximation is complemented with numerical simulations. The result shows that polarization angle has significant influence on the orientation of the field scattered by individual Si dimer, which determines the efficiency of radiative coupling and further impacts on the electric field enhancement. Moreover, we explore the feasibility of application in refractive sensing. It is shown that the figure of merit value for the proposed system of Si dimers array is as high as 306. The Si dimers array that takes advantage of multiple coupling creates new possibility to implement field-enhanced spectroscopy and refractive sensing with ultra-high sensitivity.

Probing the character of ultra-fast dislocations

DOE PAGES

Rudd, R. E.; Ruestes, C. J.; Bringa, E. M.; ...

2015-11-23

Plasticity is often controlled by dislocation motion, which was first measured for low pressure, low strain rate conditions decades ago. However, many applications require knowledge of dislocation motion at high stress conditions where the data are sparse, and come from indirect measurements dominated by the effect of dislocation density rather than velocity. Here we make predictions based on atomistic simulations that form the basis for a new approach to measure dislocation velocities directly at extreme conditions using three steps: create prismatic dislocation loops in a near-surface region using nanoindentation, drive the dislocations with a shockwave, and use electron microscopy tomore » determine how far the dislocations moved and thus their velocity at extreme stress and strain rate conditions. We report on atomistic simulations of tantalum that make detailed predictions of dislocation flow, and find that the approach is feasible and can uncover an exciting range of phenomena, such as transonic dislocations and a novel form of loop stretching. Furthermore, the simulated configuration enables a new class of experiments to probe average dislocation velocity at very high applied shear stress.« less

Metal resistance in acidophilic microorganisms and its significance for biotechnologies.

PubMed

Dopson, Mark; Holmes, David S

2014-10-01

Extremely acidophilic microorganisms have an optimal pH of <3 and are found in all three domains of life. As metals are more soluble at acid pH, acidophiles are often challenged by very high metal concentrations. Acidophiles are metal-tolerant by both intrinsic, passive mechanisms as well as active systems. Passive mechanisms include an internal positive membrane potential that creates a chemiosmotic gradient against which metal cations must move, as well as the formation of metal sulfate complexes reducing the concentration of the free metal ion. Active systems include efflux proteins that pump metals out of the cytoplasm and conversion of the metal to a less toxic form. Acidophiles are exploited in a number of biotechnologies including biomining for sulfide mineral dissolution, biosulfidogenesis to produce sulfide that can selectively precipitate metals from process streams, treatment of acid mine drainage, and bioremediation of acidic metal-contaminated milieux. This review describes how acidophilic microorganisms tolerate extremely high metal concentrations in biotechnological processes and identifies areas of future work that hold promise for improving the efficiency of these applications.

X-ray Emission Characteristics of Ultra-High Energy Density Relativistic Plasmas Created by Ultrafast Laser Irradiation of Nanowire Arrays

NASA Astrophysics Data System (ADS)

Hollinger, R. C.; Bargsten, C.; Shlyaptsev, V. N.; Pukhov, A.; Purvis, M. A.; Townsend, A.; Keiss, D.; Wang, Y.; Wang, S.; Prieto, A.; Rocca, J. J.

2014-10-01

Irradiation of ordered nanowire arrays with high contrast femtosecond laser pulses of relativistic intensity creates volumetrically heated near solid density plasmas characterized by multi-KeV temperatures and extreme degrees of ionization. The large hydrodynamic-to-radiative lifetime ratio of these plasmas results in very efficient X-ray generation. Au nanowire array plasmas irradiated at I 5×1018 Wcm-2 are measured to convert ~ 5 percent of the laser energy into h ν > 0.9 KeV X-rays, and >1 × 10-4 into h ν > 9 KeV photons, creating bright picosecond X-ray sources. The angular distribution of the higher energy photons is measured to change from isotropic into annular as the intensity increases, while softer X-ray emission (h ν >1 KeV) remains isotropic and nearly unchanged. Model simulations suggest the unexpected annular distribution of the hard X-rays might result from bremsstrahlung of fast electrons confined in a high aspect ratio near solid density plasma in which the electron-ion collision mean free-path is of the order of the plasma thickness. Work supported by the U.S Department of Energy, Fusion Energy Sciences and the Defense Threat Reduction Agency Grant HDTRA-1-10-1-0079. A.P was supported by of DFG-funded project TR18.

NDE standards for high temperature materials

NASA Technical Reports Server (NTRS)

Vary, Alex

1991-01-01

High temperature materials include monolithic ceramics for automotive gas turbine engines and also metallic/intermetallic and ceramic matrix composites for a range of aerospace applications. These are materials that can withstand extreme operating temperatures that will prevail in advanced high-efficiency gas turbine engines. High temperature engine components are very likely to consist of complex composite structures with three-dimensionality interwoven and various intermixed ceramic fibers. The thermomechanical properties of components made of these materials are actually created in-place during processing and fabrication stages. The complex nature of these new materials creates strong incentives for exact standards for unambiguous evaluations of defects and microstructural characteristics. NDE techniques and standards that will ultimately be applicable to production and quality control of high temperature materials and structures are still emerging. The needs range from flaw detection to below 100 micron levels in monolithic ceramics to global imaging of fiber architecture and matrix densification anomalies in composites. The needs are different depending on the processing stage, fabrication method, and nature of the finished product. The standards are discussed that must be developed in concert with advances in NDE technology, materials processing research, and fabrication development. High temperature materials and structures that fail to meet stringent specifications and standards are unlikely to compete successfully either technologically or in international markets.

Enhancement of DNaseI Salt Tolerance by Mimicking the Domain Structure of DNase from an Extremely Halotolerant Bacterium Thioalkalivibrio sp. K90mix

PubMed Central

Alzbutas, Gediminas; Kaniusaite, Milda; Lagunavicius, Arunas

2016-01-01

In our previous work we showed that DNaseI-like protein from an extremely halotolerant bacterium Thioalkalivibrio sp. K90mix retained its activity at salt concentrations as high as 4 M NaCl and the key factor allowing this was the C-terminal DNA-binding domain, which comprised two HhH (helix-hairpin-helix) motifs. The further investigations revealed that this domain originated from proteins related to bacterial competence ComEA/ComE proteins. It is likely that in the course of evolution the DNA-binding domain from these proteins was fused to a metallo-β-lactamase superfamily domain. Very likely such domain organization having proteins subsequently “donated” the DNA-binding domain to bacterial DNases. In this study we have mimicked this evolutionary step by fusing bovine DNaseI and DNA-binding domains. We have created two fusions: one harboring the DNA-binding domain of DNaseI-like protein from Thioalkalivibrio sp. K90mix and the second one harboring the DNA-binding domain of bacterial competence protein ComEA from Bacillus subtilis. Both domains enhanced salt tolerance of DNaseI, albeit to different extent. Molecular modeling revealed the essential differences between their interaction with DNA shedding some light on the differences in salt tolerance. In this study we have enhanced salt tolerance of bovine DNaseI; thus, we successfully mimicked the Nature’s evolutionary engineering that created the extremely halotolerant bacterial DNase. We have demonstrated that the newly engineered DNaseI variants can be successfully used in applications where activity of the wild type bovine DNaseI is impeded by buffers used. PMID:26939122

Random sampling technique for ultra-fast computations of molecular opacities for exoplanet atmospheres

NASA Astrophysics Data System (ADS)

Min, M.

2017-10-01

Context. Opacities of molecules in exoplanet atmospheres rely on increasingly detailed line-lists for these molecules. The line lists available today contain for many species up to several billions of lines. Computation of the spectral line profile created by pressure and temperature broadening, the Voigt profile, of all of these lines is becoming a computational challenge. Aims: We aim to create a method to compute the Voigt profile in a way that automatically focusses the computation time into the strongest lines, while still maintaining the continuum contribution of the high number of weaker lines. Methods: Here, we outline a statistical line sampling technique that samples the Voigt profile quickly and with high accuracy. The number of samples is adjusted to the strength of the line and the local spectral line density. This automatically provides high accuracy line shapes for strong lines or lines that are spectrally isolated. The line sampling technique automatically preserves the integrated line opacity for all lines, thereby also providing the continuum opacity created by the large number of weak lines at very low computational cost. Results: The line sampling technique is tested for accuracy when computing line spectra and correlated-k tables. Extremely fast computations ( 3.5 × 105 lines per second per core on a standard current day desktop computer) with high accuracy (≤1% almost everywhere) are obtained. A detailed recipe on how to perform the computations is given.

X-ray free-electron laser studies of dense plasmas

NASA Astrophysics Data System (ADS)

Vinko, Sam M.

2015-10-01

> The high peak brightness of X-ray free-electron lasers (FELs), coupled with X-ray optics enabling the focusing of pulses down to sub-micron spot sizes, provides an attractive route to generating high energy-density systems on femtosecond time scales, via the isochoric heating of solid samples. Once created, the fundamental properties of these plasmas can be studied with unprecedented accuracy and control, providing essential experimental data needed to test and benchmark commonly used theoretical models and assumptions in the study of matter in extreme conditions, as well as to develop new predictive capabilities. Current advances in isochoric heating and spectroscopic plasma studies on X-ray FELs are reviewed and future research directions and opportunities discussed.

The Enhancement of Reusability of Course Content and Scenarios in Unified e-Learning Environment for Schools

ERIC Educational Resources Information Center

Limanauskiene, Virginija; Stuikys, Vytautas

2009-01-01

With the expansion of e-learning, the understanding and evaluation of already created e-learning environments is becoming an extremely important issue. One way to dealing with the problem is analysis of case studies, i.e. already created environments, from the reuse perspective. The paper presents a general framework and model to assess UNITE, the…

Characterizing the Spatial Contiguity of Extreme Precipitation over the US in the Recent Past

NASA Astrophysics Data System (ADS)

Touma, D. E.; Swain, D. L.; Diffenbaugh, N. S.

2016-12-01

The spatial characteristics of extreme precipitation over an area can define the hydrologic response in a basin, subsequently affecting the flood risk in the region. Here, we examine the spatial extent of extreme precipitation in the US by defining its "footprint": a contiguous area of rainfall exceeding a certain threshold (e.g., 90th percentile) on a given day. We first characterize the climatology of extreme rainfall footprint sizes across the US from 1980-2015 using Daymet, a high-resolution observational gridded rainfall dataset. We find that there are distinct regional and seasonal differences in average footprint sizes of extreme daily rainfall. In the winter, the Midwest shows footprints exceeding 500,000 sq. km while the Front Range exhibits footprints of 10,000 sq. km. Alternatively, the summer average footprint size is generally smaller and more uniform across the US, ranging from 10,000 sq. km in the Southwest to 100,000 sq. km in Montana and North Dakota. Moreover, we find that there are some significant increasing trends of average footprint size between 1980-2015, specifically in the Southwest in the winter and the Northeast in the spring. While gridded daily rainfall datasets allow for a practical framework in calculating footprint size, this calculation heavily depends on the interpolation methods that have been used in creating the dataset. Therefore, we assess footprint size using the GHCN-Daily station network and use geostatistical methods to define footprints of extreme rainfall directly from station data. Compared to the findings from Daymet, preliminary results using this method show fewer small daily footprint sizes over the US while large footprints are of similar number and magnitude to Daymet. Overall, defining the spatial characteristics of extreme rainfall as well as observed and expected changes in these characteristics allows us to better understand the hydrologic response to extreme rainfall and how to better characterize flood risks.

A theoretical study of the hydrogen-storage potential of (H2)4CH4 in metal organic framework materials and carbon nanotubes.

PubMed

Li, Q; Thonhauser, T

2012-10-24

The hydrogen-methane compound (H(2))(4)CH(4)-or for short H4M-is one of the most promising hydrogen-storage materials. This van der Waals compound is extremely rich in molecular hydrogen: 33.3 mass%, not including the hydrogen bound in CH(4); including it, we reach even 50.2 mass%. Unfortunately, H4M is not stable under ambient pressure and temperature, requiring either low temperature or high pressure. In this paper, we investigate the properties and structure of the molecular and crystalline forms of H4M, using ab initio methods based on van der Waals DFT (vdW-DF). We further investigate the possibility of creating the pressures required to stabilize H4M through external agents such as metal organic framework (MOF) materials and carbon nanotubes, with very encouraging results. In particular, we find that certain MOFs can create considerable pressure for H4M in their cavities, but not enough to stabilize it at room temperature, and moderate cooling is still necessary. On the other hand, we find that all the investigated carbon nanotubes can create the high pressures required for H4M to be stable at room temperature, with direct implications for new and exciting hydrogen-storage applications.

Religious Extremism in Pakistan

DTIC Science & Technology

2014-12-01

selected ROs in Pakistan have adopted extreme views due to the political and social context in the country. They then use this socio-economic link to...political and social context in the country. They then use this socio-economic link to indoctrinate citizens with extremist ideologies, thus creating a...Pakistan Support to Recovery and Rehabilitation of Basic Social Services for the Earthquake-Affected Population 2007‒2008,” UNICEF, 1 September 2007

Eolian paleotopographic highs as stratigraphic traps: origin and distinction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eschner, T.B.; Kocurek, G.A.

1985-02-01

Significant hydrocarbon accumulations occur where eolian paleotopographic highs are preserved beneath transgressive marine deposits. Paleotopographic highs can represent erosional remnants of an unconformity, or partly preserved eolian dunes, or combinations of both. Paleotopography reflects the extent of modification undergone by eolian units prior to or during transgression. Modification varies between extremes of (1) destruction - where eolian deposits are deeply eroded and the former dunal profile is lost, and (2) preservation - where dunes and interdune areas are preserved nearly intact. The extent of modification that occurs during transgression is controlled primarily by (1) the energy of the transgressing sea,more » (2) the speed of transgression, and (3) the abundance of sand-stabilizing early cements or plants. High-energy seas destroy dunes through persistent erosion by tides and waves and by initiating dune collapse and mass flowage of dune sands. Preservation occurs where quiescent seas flood interdune areas and create shallow to periodically emergent marine environments, such as interdune sabkhas or tidal flats. Gradual filling of interdune areas with shallow marine sediments can fortify and preserve adjacent dunes. These varied processes that interact between marine and eolian environments to create different types of topography are exemplified in ancient eolian-marine sequences of the Western Interior of North America, and preserved Holocene dunes of coastal Australia. Different types of eolian highs can be recognized by analysis of bounding surfaces in outcrop or core. An understanding of eolian-marine processes and environments that create topography allows for prediction of areas of potential stratigraphic traps.« less

The Extreme Hosts of Extreme Supernovae

NASA Astrophysics Data System (ADS)

Neill, James D.

2012-01-01

We present the results from a deeper survey of Luminous Supernova (LSN) hosts with the Galaxy Evolution Explorer (GALEX). We have added new, multiple kilo-second observations to our original observations of seventeen LSN hosts providing better constraints on their physical properties. We place the LSNe hosts on the galaxy NUV-r versus M(r) color magnitude diagram (CMD) with a larger comparison sample ( 26,000) to illustrate the extreme nature of these galaxies. The LSN hosts favor low-density regions of the galaxy CMD falling on the blue edge of the blue cloud toward the low luminosity end. The new observations provide tighter constraints on the star formation rates (SFRs) and stellar masses, M(*), and show that the LSNe result from regions of high specific star formation and yet low total SFR. This regime is of particular interest for exploring the upper end of the stellar IMF and its variation. If our understanding of the progenitors of the LSNe leans toward very massive (> 200 M_sun) progenitors, the potential for a conflict with IMF theory exists because the conditions found in the hosts producing the LSNe should not create such massive stars. If it also required that LSNe can only be produced in primordial or very low metallicity environments, then they will also provide evidence for strong variation in metallicity within a dwarf galaxy, since their masses are consistent with low, but not extreme metallicity.

Peatland Microbial Communities as Indicators of the Extreme Atmospheric Dust Deposition.

PubMed

Fiałkiewicz-Kozieł, B; Smieja-Król, B; Ostrovnaya, T M; Frontasyeva, M; Siemińska, A; Lamentowicz, M

We investigated a peat profile from the Izery Mountains, located within the so-called Black Triangle, the border area of Poland, Czech Republic, and Germany. This peatland suffered from an extreme atmospheric pollution during the last 50 years, which created an exceptional natural experiment to examine the impact of pollution on peatland microbes. Testate amoebae (TA), Centropyxis aerophila and Phryganella acropodia , were distinguished as a proxy of atmospheric pollution caused by extensive brown coal combustion. We recorded a decline of mixotrophic TA and development of agglutinated taxa as a response for the extreme concentration of Al (30 g kg -1 ) and Cu (96 mg kg -1 ) as well as the extreme amount of fly ash particles determined by scanning electron microscopy (SEM) analysis, which were used by TA for shell construction. Titanium (5.9 %), aluminum (4.7 %), and chromium (4.2 %) significantly explained the highest percentage of the variance in TA data. Elements such as Al, Ti, Cr, Ni, and Cu were highly correlated ( r  > 0.7, p  < 0.01) with pseudostome position/body size ratio and pseudostome position. Changes in the community structure, functional diversity, and mechanisms of shell construction were recognized as the indicators of dust pollution. We strengthen the importance of the TA as the bioindicators of the recent atmospheric pollution.

Ultralight nanofibre-assembled cellular aerogels with superelasticity and multifunctionality.

PubMed

Si, Yang; Yu, Jianyong; Tang, Xiaomin; Ge, Jianlong; Ding, Bin

2014-12-16

Three-dimensional nanofibrous aerogels (NFAs) that are both highly compressible and resilient would have broad technological implications for areas ranging from electrical devices and bioengineering to damping materials; however, creating such NFAs has proven extremely challenging. Here we report a novel strategy to create fibrous, isotropically bonded elastic reconstructed (FIBER) NFAs with a hierarchical cellular structure and superelasticity by combining electrospun nanofibres and the fibrous freeze-shaping technique. Our approach causes the intrinsically lamellar deposited electrospun nanofibres to assemble into elastic bulk aerogels with tunable densities and desirable shapes on a large scale. The resulting FIBER NFAs exhibit densities of >0.12 mg cm(-3), rapid recovery from deformation, efficient energy absorption and multifunctionality in terms of the combination of thermal insulation, sound absorption, emulsion separation and elasticity-responsive electric conduction. The successful synthesis of such fascinating materials may provide new insights into the design and development of multifunctional NFAs for various applications.

Multi-agent electricity market modeling with EMCAS.

DOE Office of Scientific and Technical Information (OSTI.GOV)

North, M.; Macal, C.; Conzelmann, G.

2002-09-05

Electricity systems are a central component of modern economies. Many electricity markets are transitioning from centrally regulated systems to decentralized markets. Furthermore, several electricity markets that have recently undergone this transition have exhibited extremely unsatisfactory results, most notably in California. These high stakes transformations require the introduction of largely untested regulatory structures. Suitable tools that can be used to test these regulatory structures before they are applied to real systems are required. Multi-agent models can provide such tools. To better understand the requirements such as tool, a live electricity market simulation was created. This experience helped to shape the developmentmore » of the multi-agent Electricity Market Complex Adaptive Systems (EMCAS) model. To explore EMCAS' potential, several variations of the live simulation were created. These variations probed the possible effects of changing power plant outages and price setting rules on electricity market prices.« less

Novel Materials Containing Single-Wall Carbon Nanotubes Wrapped in Polymer Molecules

NASA Technical Reports Server (NTRS)

Smalley, Richard E.; O'Connell, Michael J.; Smith, Kenneth; Colbert, Daniel T.

2009-01-01

In this design, single-wall carbon nanotubes (SWNTs) have been coated in polymer molecules to create a new type of material that has low electrical conductivity, but still contains individual nanotubes, and small ropes of individual nanotubes, which are themselves good electrical conductors and serve as small conducting rods immersed in an electrically insulating matrix. The polymer is attached through weak chemical forces that are primarily non-covalent in nature, caused primarily through polarization rather than the sharing of valence electrons. Therefore, the electronic structure of the SWNT involved is substantially the same as that of free, individual (and small ropes of) SWNT. Their high conductivity makes the individual nanotubes extremely electrically polarizable, and materials containing these individual, highly polarizable molecules exhibit novel electrical properties including a high dielectric constant.

Heavy nucleus collisions between 20 and 60 GeV/nucleon

NASA Technical Reports Server (NTRS)

Burnett, T. H.; Dake, S.; Fuki, M.; Gregory, J. C.; Hayashi, T.; Holynski, R.; Iwai, J.; Jones, W. V.; Jurak, A.; Lord, J. J.

1985-01-01

Interest in studying relativistic nucleus-nucleus interations arises from the fact that they offer an opportunity to probe nuclear matter at high density and temperature. It is expected that under such extreme conditions a transition from hadronic matter into quark-gluon plasma occurs and that in the interactions of highly relativistic nuclei such conditions are created. Cosmic rays remain a unique source of high energy heavy nuclei. The Japanese-American Cooperative Emulsion Experiment (JACEE-3) was designed to study the collisions of heavy cosmic ray nuclei with different nuclear targets at energies beyond 20 GeV/nucleon. JACEE-3 experiment was carried out using a combined electronic counters and an emulsion chamber detector, which was exposed to the cosmic rays on a balloon at an altitude of 5 g/sq cm.

Batch-fabricated high-performance graphene Hall elements

PubMed Central

Xu, Huilong; Zhang, Zhiyong; Shi, Runbo; Liu, Honggang; Wang, Zhenxing; Wang, Sheng; Peng, Lian-Mao

2013-01-01

Hall elements are by far the most widely used magnetic sensor. In general, the higher the mobility and the thinner the active region of the semiconductor used, the better the Hall device. While most common magnetic field sensors are Si-based Hall sensors, devices made from III-V compounds tend to favor over that based on Si. However these devices are more expensive and difficult to manufacture than Si, and hard to be integrated with signal-processing circuits for extending function and enforcing performance. In this article we show that graphene is intrinsically an ideal material for Hall elements which may harness the remarkable properties of graphene, i.e. extremely high carrier mobility and atomically thin active body, to create ideal magnetic sensors with high sensitivity, excellent linearity and remarkable thermal stability. PMID:23383375

Reflection type metasurface designed for high efficiency vectorial field generation

NASA Astrophysics Data System (ADS)

Wang, Shiyi; Zhan, Qiwen

2016-07-01

We propose a reflection type metal-insulator-metal (MIM) metasurface composed of hybrid nano-antennas for comprehensive spatial engineering of the properties of optical fields. The capability of such structure is illustrated in the design of a device that can be used to produce a radially polarized vectorial beam for optical needle field generation. This device consists of uniformly segmented sectors of high efficiency MIM metasurface. With each of the segment sector functioning as a local quarter-wave-plate (QWP), the device is designed to convert circularly polarized incidence into local linear polarization to create an overall radial polarization with corresponding binary phases and extremely high dynamic range amplitude modulation. The capability of such devices enables the generation of nearly arbitrarily complex optical fields that may find broad applications that transcend disciplinary boundaries.

KSC-2009-2957

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a crane moves a container toward the deck of the U.S. Army landing craft utility ship Brandy Station. Inside is the control center for the X-band radar installed on the deck of the ship. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2958

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a crane lowers a container toward the deck of the U.S. Army landing craft utility ship Brandy Station. Inside is the control center for the X-band radar installed on the deck of the ship. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

KSC-2009-2956

NASA Image and Video Library

2009-05-06

CAPE CANAVERAL, Fla. – In Port Canaveral, Fla., a container is lifted from the transporter for transfer to the U.S. Army landing craft utility ship Brandy Station. Inside is the control center for the X-band radar installed on the deck of the ship. The radar will provide critical support during launch of space shuttle Atlantis on the STS-125 mission. The radar will work with smaller X-band radars placed on the solid rocket booster retrieval ship Liberty Star to provide extremely high-resolution images of any debris that might be created during Atlantis' launch. Photo credit: NASA/Kim Shiflett

Constructing An Event Based Aerosol Product Under High Aerosol Loading Conditions

NASA Astrophysics Data System (ADS)

Levy, R. C.; Shi, Y.; Mattoo, S.; Remer, L. A.; Zhang, J.

2016-12-01

High aerosol loading events, such as the Indonesia's forest fire in Fall 2015 or the persistent wintertime haze near Beijing, gain tremendous interests due to their large impact on regional visibility and air quality. Understanding the optical properties of these events and further being able to simulate and predict these events are beneficial. However, it is a great challenge to consistently identify and then retrieve aerosol optical depth (AOD) from passive sensors during heavy aerosol events. Some reasons include:1). large differences between optical properties of high-loading aerosols and those under normal conditions, 2) spectral signals of optically thick aerosols can be mistaken with surface depending on aerosol types, and 3) Extremely optically thick aerosol plumes can also be misidentified as clouds due to its high optical thickness. Thus, even under clear-sky conditions, the global distribution of extreme aerosol events is not well captured in datasets such as the MODIS Dark-Target (DT) aerosol product. In this study, with the synthetic use of OMI Aerosol Index, MODIS cloud product, and operational DT product, the heavy smoke events over the seven sea region are identified and retrieved over the dry season. An event based aerosol product that would compensate the standard "global" aerosol retrieval will be created and evaluated. The impact of missing high AOD retrievals on the regional aerosol climatology will be studied using this newly developed research product.

Simulation of Extreme Surface Winds by Regional Climate Models in the NARCCAP Archive

NASA Astrophysics Data System (ADS)

Hatteberg, R.; Takle, E. S.

2011-12-01

Surface winds play a significant role in many natural processes as well as providing a very important ecological service for many human activities. Surface winds ventilate pollutants and heat from our cities, contribute to pollination for our crops, and regulate the fluxes of heat, moisture, and carbon dioxide from the earth's surface. Many environmental models such as biogeochemical models, crop models, lake models, pollutant transport models, etc., use surface winds as a key variable. Studies of the impacts of climate change and climate variability on a wide range of natural systems and coupled human-natural systems frequently need information on how surface wind speeds will change as greenhouse gas concentrations in the earth's atmosphere change. We have studied the characteristics of extreme winds - both high winds and low winds - created by regional climate models (RCMs) in the NARCCAP archives. We evaluated the capabilities of five RCMs forced by NCEP reanalysis data as well as global climate model (GCM) data for contemporary and future scenario climates to capture the observed statistical distribution of surface winds, both high-wind events and low-wind conditions. Our domain is limited to the Midwest (37°N to 49°N, -82°W to -101°W) with the Great Lakes masked out, which eliminates orographic effects that may contribute to regional circulations. The majority of this study focuses on the warm seasonal in order to examine derechos on the extreme high end and air pollution and plant processes on the low wind speed end. To examine extreme high winds we focus on derechos, which are long-lasting convectively driven extreme wind events that frequently leave a swath of damage extending across multiple states. These events are unusual in that, despite their relatively small spatial scale, they can persist for hours or even days, drawing energy from well-organized larger mesoscale or synoptic scale processes. We examine the ability of NARCCAP RCMs to reproduce these isolated extreme events by assessing their existence, location, magnitude, synoptic linkage, initiation time and duration as compared to the record of observations of derechos in the Midwest and Northeast US. We find that RCMs do reproduce features with close resemblance to derechos although their magnitudes are considerably below those observed (which may be expected given the 50-km grid spacing of the RCM models). Extreme low wind speeds in summer are frequently associated with stagnation conditions leading to high air pollution events in major cities. Low winds also lead to reduced evapotranspiration by crops, which can impact phenological processes (e.g. pollination and seed fertilization, carbon uptake by plants). We evaluate whether RCMs can simulate climatic distributions of low-wind conditions in the northern US. Results show differences among models in their ability to reproduce observed characteristics of low summer-time winds. Only one model reproduces observed high frequency of calm night-time surface winds in summer, which suggests a need to improve model capabilities for simulating extreme stagnation events.

Ultra-intense Pair Creation using the Texas Petawatt Laser and Applications

NASA Astrophysics Data System (ADS)

Liang, Edison; Henderson, Alexander; Clarke, Taylor; Lo, Willie; Chaguine, Petr; Dyer, Gilliss; Riley, Nathan; Serratto, Kristina; Donovan, Michael; Ditmire, Todd

2014-10-01

Pair plasmas and intense gamma-ray sources are ubiquitous in the high-energy universe, from pulser winds to gamma-ray bursts (GRB). Their study can be greatly enhanced if such sources can be recreated in the laboratory under controlled conditions. In 2012 and 2013, a joint Rice-University of Texas team performed over 130 laser shots on thick gold and platinum targets using the 100 Joule Texas Petawatt Laser in Austin. The laser intensity of many shots exceeded 1021 W.cm-2 with pulses as short as 130 fs. These experiments probe a new extreme regime of ultra-intense laser - high-Z solid target interactions never achieved before. In addition to creating copious pairs with the highest density (>1015/cc) and emergent e +/e- ratio exceeding 20% in many shots, these experiments also created the highest density multi-MeV gamma-rays, comparable in absolute numbers to those found inside a gamma-ray burst (GRB). Potential applications of such intense pair and gamma-ray sources to laboratory astrophysics and innovative technologies will be discussed. Work supported by DOE HEDLP program.

Development and recent results from the Subaru coronagraphic extreme adaptive optics system

NASA Astrophysics Data System (ADS)

Jovanovic, N.; Guyon, O.; Martinache, F.; Clergeon, C.; Singh, G.; Kudo, T.; Newman, K.; Kuhn, J.; Serabyn, E.; Norris, B.; Tuthill, P.; Stewart, P.; Huby, E.; Perrin, G.; Lacour, S.; Vievard, S.; Murakami, N.; Fumika, O.; Minowa, Y.; Hayano, Y.; White, J.; Lai, O.; Marchis, F.; Duchene, G.; Kotani, T.; Woillez, J.

2014-07-01

The Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) instrument is one of a handful of extreme adaptive optics systems set to come online in 2014. The extreme adaptive optics correction is realized by a combination of precise wavefront sensing via a non-modulated pyramid wavefront sensor and a 2000 element deformable mirror. This system has recently begun on-sky commissioning and was operated in closed loop for several minutes at a time with a loop speed of 800 Hz, on ~150 modes. Further suppression of quasi-static speckles is possible via a process called "speckle nulling" which can create a dark hole in a portion of the frame allowing for an enhancement in contrast, and has been successfully tested on-sky. In addition to the wavefront correction there are a suite of coronagraphs on board to null out the host star which include the phase induced amplitude apodization (PIAA), the vector vortex, 8 octant phase mask, 4 quadrant phase mask and shaped pupil versions which operate in the NIR (y-K bands). The PIAA and vector vortex will allow for high contrast imaging down to an angular separation of 1 λ/D to be reached; a factor of 3 closer in than other extreme AO systems. Making use of the left over visible light not used by the wavefront sensor is VAMPIRES and FIRST. These modules are based on aperture masking interferometry and allow for sub-diffraction limited imaging with moderate contrasts of ~100-1000:1. Both modules have undergone initial testing on-sky and are set to be fully commissioned by the end of 2014.

Revisiting the 1993 historical extreme precipitation and damaging flood event in Central Nepal

NASA Astrophysics Data System (ADS)

Marahatta, S.; Adhikari, L.; Pokharel, B.

2017-12-01

Nepal is ranked the fourth most climate-vulnerable country in the world and it is prone to different weather-related hazards including droughts, floods, and landslides [Wang et al., 2013; Gillies et al., 2013]. Although extremely vulnerable to extreme weather events, there are no extreme weather warning system established to inform public in Nepal. Nepal has witnessed frequent drought and flood events, however, the extreme precipitation that occurred on 19-20 July 1993 created a devastating flood and landslide making it the worst weather disaster in the history of Nepal. During the second week of July, Nepal and northern India experienced abnormal dry condition due to the shifting of the monsoon trough to central India. The dry weather changed to wet when monsoon trough moved northward towards foothills of the Himalayas. Around the same period, a low pressure center was located over the south-central Nepal. The surface low was supported by the mid-, upper-level shortwave and cyclonic vorticity. A meso-scale convective system created record breaking one day rainfall (540 mm) in the region. The torrential rain impacted the major hydropower reservoir, Bagmati barrage in Karmaiya and triggered many landslides and flash floods. The region had the largest hydropower (Kulekhani hydropower, 92 MW) of the country at that time and the storm event deposited extremely large amount of sediments that reduced one-fourth (4.8 million m3) of reservoir dead storage (12 million m3). The 1-in-1000 years flood damaged the newly constructed barrage and took more than 700 lives. Major highways were damaged cutting off supply of daily needed goods, including food and gas, in the capital city, Kathmandu, for more than a month. In this presentation, the meteorological conditions of the extreme event will be diagnosed and the impact of the sedimentation due to the flood on Kulekhani reservoir and hydropower generation will be discussed.

Increasing your HCAHPS scores with Extreme Customer Service.

PubMed

Clouarte, Joe

2016-10-01

Providing great customer service is extremely critical in the healthcare setting, especially when it comes to HCAHBPS (Hospital Consumer Assessment of Health care Providers and Systems) scores, the author says. While there are several service training programs within healthcare, they often require six to eight minutes of interaction with patients or guests. This works well for clinical staff, he says, but when it comes to non-clinical staff, including security officers, many times they only have fifteen or thirty seconds to create positive patient or guest experience. In this article he describes Extreme Customer Service © a program he has developed to fill that customer gap for non-clinical staff.

Venous Ultrasound (Extremities)

MedlinePlus

... the patient. Because ultrasound images are captured in real-time, they can show the structure and movement of ... by a computer, which in turn creates a real-time picture on the monitor. One or more frames ...

"New Climate" Warmed, "New Atmospheric Circulation" and "Extreme" Meteorological Phenomena associated with El Niño 2015-2016

NASA Astrophysics Data System (ADS)

Karrouk, M. S.

2016-12-01

Cumulating ocean-atmospheric thermal energy caused by global warming has resulted in the reversal of the energy balance towards the poles. This situation is characterized by a new ocean-continental thermal distribution: over the ocean, the balance is more in excess than in the mainland, if not the opposite when the balance is negative inland.Thanks to satellite observation and daily monitoring of meteorological conditions for more than ten years, we have observed that the positive balance has shifted more towards the poles, mainly in the northern hemisphere. Subtropical anticyclones are strengthened and have extended to high latitudes, especially over the Atlantic and Pacific oceans. This situation creates global peaks strengthened in winter periods, and imposes on cosmic cold the deep advection toward the south under the form of planetary valleys "Polar Vortex".This situation imposes on the jet stream a pronounced ripple and installs a meridional atmospheric circulation in winter, which brings the warm tropical air masses to reach the Arctic Circle, and cold polar air masses to reach North Africa and Florida.This situation creates unusual atmospheric events, characterized by hydrothermal "extreme" conditions: excessive heat at high latitudes, accompanied by heavy rains and floods, as well as cold at low latitudes and the appearance of snow in the Sahara!The populations are profoundly influenced by the new phenomena. The socioeconomic infrastructures can no longer assume their basic functions and man when unprotected is weak and hence the advanced vulnerability of all the regions especially those belonging to poor and developing countriesRecent studies have shown that global and regional climate system is affected by extreme events of El Niño. Statistical and dynamic links have been confirmed in Northern Africa and Western Europe; hence the importance of the fall situation and winter 2015-2016.These conditions are the consequences of the "New Climate" warmed, strengthened by the strong El Niño event in 2015 decennial.These are the characteristics of "New Meteorological Events" resulting from the "New Atmospheric Circulation", caused by the "New planetary Climate" forcing by El Niño event, consequence of "Global Warming".

Microfabrication of polymeric surfaces with extreme wettability using hot embossing

NASA Astrophysics Data System (ADS)

Falah Toosi, Salma; Moradi, Sona; Ebrahimi, Marzieh; Hatzikiriakos, Savvas G.

2016-08-01

Hot embossing was utilized to imprint topographical metallic patterns on the surfaces of thermoplastic polymers in order to create superhydrophobic and superoleophobic polymeric surfaces. The stainless steel (SS) micro/nano structured templates were fabricated using femtosecond laser ablation. The SS laser ablated templates were employed to imprint micron/submicron periodic structures onto the surface of high density polyethylene (HDPE), polylactic acid (PLA), and medical PVC at temperatures slightly above their melting points and pressures in the range of 3-12 MPa. Results have shown that the water contact angle (CA) of imprinted polymers increased to above 160° in the case of PLA and HDPE, while their water contact angle hysteresis (CAH) were significantly below 10°. In the case of medical-PVC, imprinting produced morphologies with high CA and high CAH (petal effect) due to the adhesion forces developed at the interface between the hydrophilic plasticizer of medical-PVC (TOTM) and water droplets. It is also noted that the re-entrant superoleophobic patterns created on HDPE through imprinting closely resemble the patterns found on the surface of filefish skin that is densely angled microfiber arrays. This bioinspired surface is highly capable of repelling both polar (water) and non-polar liquids of low surface tension and meets the superoleophobicity criteria.

The climatic characteristics of extreme precipitations for short-term intervals in the watershed of Lake Maggiore

NASA Astrophysics Data System (ADS)

Saidi, Helmi; Ciampittiello, Marzia; Dresti, Claudia; Ghiglieri, Giorgio

2013-07-01

Alpine and Mediterranean areas are undergoing a profound change in the typology and distribution of rainfall. In particular, there has been an increase in consecutive non-rainy days, and an escalation of extreme rainy events. The climatic characteristic of extreme precipitations over short-term intervals is an object of study in the watershed of Lake Maggiore, the second largest freshwater basin in Italy (located in the north-west of the country) and an important resource for tourism, fishing and commercial flower growing. The historical extreme rainfall series with high-resolution from 5 to 45 min and above: 1, 2, 3, 6, 12 and 24 h collected at different gauges located at representative sites in the watershed of Lake Maggiore, have been computed to perform regional frequency analysis of annual maxima precipitation based on the L-moments approach, and to produce growth curves for different return-period rainfall events. Because of different rainfall-generating mechanisms in the watershed of Lake Maggiore such as elevation, no single parent distribution could be found for the entire study area. This paper concerns an investigation designed to give a first view of the temporal change and evolution of annual maxima precipitation, focusing particularly on both heavy and extreme events recorded at time intervals ranging from few minutes to 24 h and also to create and develop an extreme storm precipitation database, starting from historical sub-daily precipitation series distributed over the territory. There have been two-part changes in extreme rainfall events occurrence in the last 23 years from 1987 to 2009. Little change is observed in 720 min and 24-h precipitations, but the change seen in 5, 10, 15, 20, 30, 45, 60, 120, 180 and 360 min events is significant. In fact, during the 2000s, growth curves have flattened and annual maxima have decreased.

Strategic tradeoffs in competitor dynamics on adaptive networks.

PubMed

Hébert-Dufresne, Laurent; Allard, Antoine; Noël, Pierre-André; Young, Jean-Gabriel; Libby, Eric

2017-08-08

Recent empirical work highlights the heterogeneity of social competitions such as political campaigns: proponents of some ideologies seek debate and conversation, others create echo chambers. While symmetric and static network structure is typically used as a substrate to study such competitor dynamics, network structure can instead be interpreted as a signature of the competitor strategies, yielding competition dynamics on adaptive networks. Here we demonstrate that tradeoffs between aggressiveness and defensiveness (i.e., targeting adversaries vs. targeting like-minded individuals) creates paradoxical behaviour such as non-transitive dynamics. And while there is an optimal strategy in a two competitor system, three competitor systems have no such solution; the introduction of extreme strategies can easily affect the outcome of a competition, even if the extreme strategies have no chance of winning. Not only are these results reminiscent of classic paradoxical results from evolutionary game theory, but the structure of social networks created by our model can be mapped to particular forms of payoff matrices. Consequently, social structure can act as a measurable metric for social games which in turn allows us to provide a game theoretical perspective on online political debates.

Hell and High Water: Practice-Relevant Adaptation Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moss, Richard H.; Meehl, G.; Lemos, Maria Carmen

2013-11-08

Recent extreme weather such as Hurricane Sandy and the 2012 drought demonstrate the vulnerability of the United States to climate extremes in the present and point to the potential for increased future damages under a changing climate. They also provide lessons for reducing harm and realizing any potential benefits. Preparedness measures – also referred to as adaptation – can cost-effectively increase resilience today and in the future. The upfront costs will be more than offset by reductions in property damage, lives and livelihoods lost, and expensive post-disaster recovery processes. While others have addressed use of science for adaptation in specificmore » sectors including biodiversity (Heller and Zavaleta, 2009) and freshwater ecosystem management (Wilby et al., 2010), or by simply taking a more pragmatic approach to adaptation under uncertainty (Hallegatte, 2009), here the authors make the case that a new, comprehensive approach is needed to create and use science to inform adaptations with applicable and sound knowledge (Kerr et al., 2011).« less

Strain response of thermal barrier coatings captured under extreme engine environments through synchrotron X-ray diffraction

NASA Astrophysics Data System (ADS)

Knipe, Kevin; Manero, Albert; Siddiqui, Sanna F.; Meid, Carla; Wischek, Janine; Okasinski, John; Almer, Jonathan; Karlsson, Anette M.; Bartsch, Marion; Raghavan, Seetha

2014-07-01

The mechanical behaviour of thermal barrier coatings in operation holds the key to understanding durability of jet engine turbine blades. Here we report the results from experiments that monitor strains in the layers of a coating subjected to thermal gradients and mechanical loads representing extreme engine environments. Hollow cylindrical specimens, with electron beam physical vapour deposited coatings, were tested with internal cooling and external heating under various controlled conditions. High-energy synchrotron X-ray measurements captured the in situ strain response through the depth of each layer, revealing the link between these conditions and the evolution of local strains. Results of this study demonstrate that variations in these conditions create corresponding trends in depth-resolved strains with the largest effects displayed at or near the interface with the bond coat. With larger temperature drops across the coating, significant strain gradients are seen, which can contribute to failure modes occurring within the layer adjacent to the interface.

Benthic surveys of the historic pearl oyster beds of Qatar reveal a dramatic ecological change.

PubMed

Smyth, D; Al-Maslamani, I; Chatting, M; Giraldes, B

2016-12-15

The study aimed to confirm the presence of historic oyster banks of Qatar and code the biotopes present. The research also collated historical records and scientific publications to create a timeline of fishery activity. The oyster banks where once an extremely productive economic resource however, intense overfishing, extreme environmental conditions and anthropogenic impacts caused a fishery collapse. The timeline highlighted the vulnerability of ecosystem engineering bivalves if overexploited. The current status of the oyster banks meant only one site could be described as oyster dominant. This was unexpected as the sites were located in areas which once supported a highly productive oyster fishery. The research revealed the devastating effect that anthropogenic impacts can have on a relatively robust marine habitat like an oyster bed and it is hoped these findings will act as a driver to investigate and map other vulnerable habitats within the region before they too become compromised. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effect of ambient humidity on the rate at which blood spots dry and the size of the spot produced.

PubMed

Denniff, Philip; Woodford, Lynsey; Spooner, Neil

2013-08-01

For shipping and storage, dried blood spot (DBS) samples must be sufficiently dry to protect the integrity of the sample. When the blood is spotted the humidity has the potential to affect the size of the spot created and the speed at which it dries. The area of DBS produced on three types of substrates were not affected by the humidity under which they were generated. DBS samples reached a steady moisture content 150 min after spotting and 90 min for humidities less than 60% relative humidity. All packaging materials examined provided some degree of protection from external extreme conditions. However, none of the packaging examined provided a total moisture barrier to extreme environmental conditions. Humidity was shown not to affect the spot area and DBS samples were ready for shipping and storage 2 h after spotting. The packing solutions examined all provided good protection from external high humidity conditions.

Materials Properties and Solvated Electron Dynamics of Isolated Nanoparticles and Nanodroplets Probed with Ultrafast Extreme Ultraviolet Beams.

PubMed

Ellis, Jennifer L; Hickstein, Daniel D; Xiong, Wei; Dollar, Franklin; Palm, Brett B; Keister, K Ellen; Dorney, Kevin M; Ding, Chengyuan; Fan, Tingting; Wilker, Molly B; Schnitzenbaumer, Kyle J; Dukovic, Gordana; Jimenez, Jose L; Kapteyn, Henry C; Murnane, Margaret M

2016-02-18

We present ultrafast photoemission measurements of isolated nanoparticles in vacuum using extreme ultraviolet (EUV) light produced through high harmonic generation. Surface-selective static EUV photoemission measurements were performed on nanoparticles with a wide array of compositions, ranging from ionic crystals to nanodroplets of organic material. We find that the total photoelectron yield varies greatly with nanoparticle composition and provides insight into material properties such as the electron mean free path and effective mass. Additionally, we conduct time-resolved photoelectron yield measurements of isolated oleylamine nanodroplets, observing that EUV photons can create solvated electrons in liquid nanodroplets. Using photoemission from a time-delayed 790 nm pulse, we observe that a solvated electron is produced in an excited state and subsequently relaxes to its ground state with a lifetime of 151 ± 31 fs. This work demonstrates that femotosecond EUV photoemission is a versatile surface-sensitive probe of the properties and ultrafast dynamics of isolated nanoparticles.

Rasch Analysis of the Power as Knowing Participation in Change Tool--the Brazilian version.

PubMed

Guedes, Erika de Souza; Orozco-Vargas, Luiz Carlos; Turrini, Ruth Natália Teresa; de Sousa, Regina Márcia Cardoso; dos Santos, Mariana Alvina; da Cruz, Diná de Almeida Lopes Monteiro

2013-01-01

the objective of this study was to evaluate the items contained in the Brazilian version of the Power as Knowing Participation in Change Tool (PKPCT). investigation of the psychometric properties of the mentioned questionnaire through Rasch analysis. the data from 952 nursing assistants and 627 baccalaureate nurses were analyzed (average age 44.1 (SD=9.5); 13.0% men). The subscales Choices, Awareness, Freedom and Involvement were tested separately and presented unidimensionality; the categories of the responses given to the items were compiled from 7 to 3 levels and the items fit the model well, except for the following/leading item, in which the infit and outfit values were above 1.4; this item has also presented Differential Item Functioning (DIF) according to the participant's role. The reliability of the items was of 0.99 and the reliability of the participants ranged from 0.80 to 0.84 in the subscales. Items with extremely high levels of difficulty were not identified. the PKPCT should not be viewed as unidimensional, items with extremely high levels of difficulty in the scale need to be created and the differential functioning of some items has to be further investigated.

Designed protein reveals structural determinants of extreme kinetic stability

PubMed Central

Broom, Aron; Ma, S. Martha; Xia, Ke; Rafalia, Hitesh; Trainor, Kyle; Colón, Wilfredo; Gosavi, Shachi; Meiering, Elizabeth M.

2015-01-01

The design of stable, functional proteins is difficult. Improved design requires a deeper knowledge of the molecular basis for design outcomes and properties. We previously used a bioinformatics and energy function method to design a symmetric superfold protein composed of repeating structural elements with multivalent carbohydrate-binding function, called ThreeFoil. This and similar methods have produced a notably high yield of stable proteins. Using a battery of experimental and computational analyses we show that despite its small size and lack of disulfide bonds, ThreeFoil has remarkably high kinetic stability and its folding is specifically chaperoned by carbohydrate binding. It is also extremely stable against thermal and chemical denaturation and proteolytic degradation. We demonstrate that the kinetic stability can be predicted and modeled using absolute contact order (ACO) and long-range order (LRO), as well as coarse-grained simulations; the stability arises from a topology that includes many long-range contacts which create a large and highly cooperative energy barrier for unfolding and folding. Extensive data from proteomic screens and other experiments reveal that a high ACO/LRO is a general feature of proteins with strong resistances to denaturation and degradation. These results provide tractable approaches for predicting resistance and designing proteins with sufficient topological complexity and long-range interactions to accommodate destabilizing functional features as well as withstand chemical and proteolytic challenge. PMID:26554002

Achieving high aspect ratio wrinkles by modifying material network stress.

PubMed

Chen, Yu-Cheng; Wang, Yan; McCarthy, Thomas J; Crosby, Alfred J

2017-06-07

Wrinkle aspect ratio, or the amplitude divided by the wavelength, is hindered by strain localization transitions when an increasing global compressive stress is applied to synthetic material systems. However, many examples from living organisms show extremely high aspect ratios, such as gut villi and flower petals. We use three experimental approaches to demonstrate that these high aspect ratio structures can be achieved by modifying the network stress in the wrinkle substrate. We modify the wrinkle stress and effectively delay the strain localization transition, such as folding, to larger aspect ratios by using a zero-stress initial wavy substrate, creating a secondary network with post-curing, or using chemical stress relaxation materials. A wrinkle aspect ratio as high as 0.85, almost three times higher than common values of synthetic wrinkles, is achieved, and a quantitative framework is presented to provide understanding the different strategies and predictions for future investigations.

Practical Tips for Working as an Expedition Doctor on High-Altitude Expeditions.

PubMed

Brants, Anne; Metcalfe, Tracee

2017-09-01

Brants, Anne, and Tracee Metcalfe. Practical tips for working as an expedition doctor on high-altitude expeditions. High Alt Med Biol. 18:193-198, 2017.-With the explosion of adventure travel over the past decade, there has been a concurrent increase in mountaineering expeditions to extreme elevations, including many of the 8000-m peaks. This trend has created an increased demand for qualified expedition doctors to provide specialized medical advice and care to climbers and expedition staff. This review is intended to help physicians prepare for work on such expeditions. The authors rely heavily on their own experience and discuss the types of work available on high-altitude expeditions; how to identify a safe and reputable guiding company; personal and medical preparation; priorities in selecting or building an appropriate medical kit; and medical conditions commonly encountered on expeditions. The review concludes by considering ethical dilemmas and other difficult issues unique to this work.

Cryotherapy

MedlinePlus

... a needle-like applicator called a cryoprobe, and liquid nitrogen or argon gas to create intense cold to freeze and destroy ... of the diseased tissue and then deliver the liquid nitrogen or argon gas. Living tissue, healthy or diseased, cannot withstand extremely ...

Has the Temperature Climate of the United States Become More Extreme?

NASA Astrophysics Data System (ADS)

Stevens, L. E.; Kunkel, K.; Vose, R. S.; Knight, R. W.

2014-12-01

Extreme heat has affected parts of the United States during recent summers, particularly 2011 and 2012. Severe cold has also occurred in recent years. This has created a perception that the temperature climate of the U.S. has become more extreme. Is this the case? We address this question by computing probability distribution functions (PDFs) for each season and evaluating temporal changes for the 20th and early 21st centuries using a new gridded monthly temperature data set. We examine changes in the mean, width, and shape of the PDFs for seven U.S. regions, as defined in the third National Climate Assessment. During the past 2-3 decades, there has been a shift toward more frequent very warm months, but this has been accompanied by a decrease in the occurrence of very cold months. Thus, overall we determine that the temperature climate of the U.S. has not become more extreme. The 1930s were an earlier period of frequent very warm months, but this was primarily a result of very warm daytime temperatures, while the occurrence of months with very high nighttime temperatures was not unusually large during that period. There are important regional variations in these results. In particular, the shift to more frequent very warm months is not predominant in the southeast U.S. annually or in parts of the central U.S. in the summer. This lack of warming is a feature of daytime maximum temperature, not nighttime minimum temperature.

Foehn-induced effects on dust pollution, frontal clouds and solar radiation in the Dead Sea valley

NASA Astrophysics Data System (ADS)

Kishcha, Pavel; Starobinets, Boris; Alpert, Pinhas; Kaplan, Michael

2017-04-01

The significant drying up of the Dead Sea over the past 40 years has led to an increase in an exposed area contributing to local dust pollution. Measurements show that, sometimes, in the Dead Sea valley, dust pollution can reach extreme concentrations up to several thousands of micrograms per cubic meters. Our analysis of a meteorological situation shows that a foehn phenomenon can be a causal factor for the aforementioned extreme local dust concentration. This foehn phenomenon creates strong warm and dry winds, which are accompanied by air turbulence and temperature inversion. In our study, foehn-induced effects on dust pollution, frontal clouds and solar radiation were analyzed over the Judean Mountains ( 1000 m) and over the Dead Sea valley (-420 m), using high-resolution numerical simulations and in-situ observations at meteorological stations located across the mountain ridge. An extreme dust episode occurring on March 22, 2013, was analyzed, which was characterized by measured surface dust concentrations of up to 7000 µg m-3 in the Dead Sea valley. We simulated this foehn phenomenon with the 3-km resolution COSMO-ART model. Our analysis has shown that the foehn phenomenon could be observed even over the relatively low Judean Mountains. This analysis was based on various meteorological, pyranometer, radar, and aerosol measurements together with high-resolution model data. In the Dead Sea valley, the maximum aerosol optical depth (AOD) did not coincide with the maximum surface dust concentration. This lack of coincidence indicates difficulties in using satellite-based AOD for initializing dust concentration within numerical forecast systems over this region with complex terrain. In the western Dead Sea valley, strong foehn winds of over 20 m/s were accompanied by maximal air turbulence leading to maximal local dust emissions. Thus, the model showed that, by creating significant turbulence, the foehn phenomenon intensified the saltation (bombardment) mechanism of local dust generation in the western Dead Sea valley. In addition, the foehn-induced pronounced temperature inversion trapped dust particles beneath this inversion. These two factors caused the measured extreme surface dust concentration in the Dead Sea valley on the specified day. Radar data on March 22 showed a passage of multi-layer frontal cloudiness through the area of the Dead Sea valley leading to a sharp drop in noon solar radiation. The strong descending airflow over the downwind side of the Judean Mountains significantly influenced the frontal cloudiness leading to the formation of a cloud-free band over the Dead Sea valley.

Birth of Industry 5.0: Making Sense of Big Data with Artificial Intelligence, "The Internet of Things" and Next-Generation Technology Policy.

PubMed

Özdemir, Vural; Hekim, Nezih

2018-01-01

Driverless cars with artificial intelligence (AI) and automated supermarkets run by collaborative robots (cobots) working without human supervision have sparked off new debates: what will be the impacts of extreme automation, turbocharged by the Internet of Things (IoT), AI, and the Industry 4.0, on Big Data and omics implementation science? The IoT builds on (1) broadband wireless internet connectivity, (2) miniaturized sensors embedded in animate and inanimate objects ranging from the house cat to the milk carton in your smart fridge, and (3) AI and cobots making sense of Big Data collected by sensors. Industry 4.0 is a high-tech strategy for manufacturing automation that employs the IoT, thus creating the Smart Factory. Extreme automation until "everything is connected to everything else" poses, however, vulnerabilities that have been little considered to date. First, highly integrated systems are vulnerable to systemic risks such as total network collapse in the event of failure of one of its parts, for example, by hacking or Internet viruses that can fully invade integrated systems. Second, extreme connectivity creates new social and political power structures. If left unchecked, they might lead to authoritarian governance by one person in total control of network power, directly or through her/his connected surrogates. We propose Industry 5.0 that can democratize knowledge coproduction from Big Data, building on the new concept of symmetrical innovation. Industry 5.0 utilizes IoT, but differs from predecessor automation systems by having three-dimensional (3D) symmetry in innovation ecosystem design: (1) a built-in safe exit strategy in case of demise of hyperconnected entrenched digital knowledge networks. Importantly, such safe exists are orthogonal-in that they allow "digital detox" by employing pathways unrelated/unaffected by automated networks, for example, electronic patient records versus material/article trails on vital medical information; (2) equal emphasis on both acceleration and deceleration of innovation if diminishing returns become apparent; and (3) next generation social science and humanities (SSH) research for global governance of emerging technologies: "Post-ELSI Technology Evaluation Research" (PETER). Importantly, PETER considers the technology opportunity costs, ethics, ethics-of-ethics, framings (epistemology), independence, and reflexivity of SSH research in technology policymaking. Industry 5.0 is poised to harness extreme automation and Big Data with safety, innovative technology policy, and responsible implementation science, enabled by 3D symmetry in innovation ecosystem design.

The effects of high intensity short rest resistance exercise on muscle damage markers in men and women.

PubMed

Heavens, Kristen R; Szivak, Tunde K; Hooper, David R; Dunn-Lewis, Courtenay; Comstock, Brett A; Flanagan, Shawn D; Looney, David P; Kupchak, Brian R; Maresh, Carl M; Volek, Jeff S; Kraemer, William J

2014-04-01

Within and between sexes, universal load prescription (as assigned in extreme conditioning programs) creates extreme ranges in individual training intensities. Exercise intensity has been proposed to be the main factor determining the degree of muscle damage. Thus, the purpose of this study was to examine markers of muscle damage in resistance-trained men (n = 9) and women (n = 9) from a high intensity (HI) short rest (SR) (HI/SR) resistance exercise protocol. The HI/SR consisted of a descending pyramid scheme starting at 10 repetitions, decreasing 1 repetition per set for the back squat, bench press, and deadlift, as fast as possible. Blood was drawn pre-exercise (pre), immediately postexercise (IP), 15 minutes postexercise (+15), 60 minutes postexercise (+60), and 24 hours postexercise (+24). Women demonstrated significant increases in interleukin 6 (IL-6; IP), creatine kinase (CK; +24), myoglobin (IP, +15, +60), and a greater relative increase when compared with men (+15, +60). Men demonstrated significant increases in myoglobin (IP, +15, +60, +24), IL-6 (IP, +15), CK (IP, +60, +24), and testosterone (IP, +15). There were significant sex interactions observed in CK (IP, +60, +24) and testosterone (IP, +15, +60, +24). Women completed the protocol faster (women: 34:04 ± 9:40 minutes, men: 39:22 ± 14:43 minutes), and at a slightly higher intensity (women: 70.1 ± 3.5%, men 68.8 ± 3.1%); however, men performed significantly more work (men: 14384.6 ± 1854.5 kg, women: 8774.7 ± 1612.7 kg). Overall, women demonstrated a faster inflammatory response with increased acute damage, whereas men demonstrated a greater prolonged damage response. Therefore, strength and conditioning professionals need to be aware of the level of stress imposed on individuals when creating such volitional high intensity metabolic type workouts and allow for adequate progression and recovery from such workouts.

A framework for estimating the determinants of spatial and temporal variation in vital rates and inferring the occurrence of unobserved extreme events

PubMed Central

Jesenšek, Dušan; Crivelli, Alain J.

2018-01-01

We develop a general framework that combines long-term tag–recapture data and powerful statistical and modelling techniques to investigate how population, environmental and climate factors determine variation in vital rates and population dynamics in an animal species, using as a case study the population of brown trout living in Upper Volaja (Western Slovenia). This population has been monitored since 2004. Upper Volaja is a sink, receiving individuals from a source population living above a waterfall. We estimate the numerical contribution of the source population on the sink population and test the effects of temperature, population density and extreme events on variation in vital rates among 2647 individually tagged brown trout. We found that individuals dispersing downstream from the source population help maintain high population densities in the sink population despite poor recruitment. The best model of survival for individuals older than juveniles includes additive effects of birth cohort and sampling occasion. Fast growth of older cohorts and higher population densities in 2004–2005 suggest very low population densities in the late 1990s, which we hypothesize were caused by a flash flood that strongly reduced population size and created the habitat conditions for faster individual growth and transient higher population densities after the extreme event. PMID:29657746

A framework for estimating the determinants of spatial and temporal variation in vital rates and inferring the occurrence of unobserved extreme events.

PubMed

Vincenzi, Simone; Jesenšek, Dušan; Crivelli, Alain J

2018-03-01

We develop a general framework that combines long-term tag-recapture data and powerful statistical and modelling techniques to investigate how population, environmental and climate factors determine variation in vital rates and population dynamics in an animal species, using as a case study the population of brown trout living in Upper Volaja (Western Slovenia). This population has been monitored since 2004. Upper Volaja is a sink, receiving individuals from a source population living above a waterfall. We estimate the numerical contribution of the source population on the sink population and test the effects of temperature, population density and extreme events on variation in vital rates among 2647 individually tagged brown trout. We found that individuals dispersing downstream from the source population help maintain high population densities in the sink population despite poor recruitment. The best model of survival for individuals older than juveniles includes additive effects of birth cohort and sampling occasion. Fast growth of older cohorts and higher population densities in 2004-2005 suggest very low population densities in the late 1990s, which we hypothesize were caused by a flash flood that strongly reduced population size and created the habitat conditions for faster individual growth and transient higher population densities after the extreme event.

Picometer stable scan mechanism for gravitational wave detection in space: LISA PAAM

NASA Astrophysics Data System (ADS)

Pijnenburg, J. A. C. M.; Rijnveld, N.

2017-11-01

Detection and observation of gravitational waves requires extreme stability in the frequency range 0.03 mHz to 1 Hz. The Laser Interferometer Space Antenna (LISA) mission will attain this by creating a giant interferometer in space, based on free floating proof masses in three spacecrafts. Due to orbit evolution and time delay in the interferometer arms, the direction of transmitted light changes. To solve this problem, a picometer stable Point-Ahead Angle Mechanism (PAAM) was designed, realized and successfully tested. The PAAM concept is based on a rotatable mirror. The critical requirements are the contribution to the optical path length (less than 1.4 pm / rt Hz) and the angular jitter (less than 8 nrad / rt Hz). Extreme dimensional stability is achieved by manufacturing a monolithical Haberland hinge mechanism out of Ti6Al4V, through high precision wire erosion. Extreme thermal stability is realized by placing the thermal center on the surface of the mirror. Because of piezo actuator noise and leakage, the PAAM has to be controlled in closed-loop. To meet the requirements in the low frequencies, an active target capacitance-to-digital converter is used. Interferometric measurements with a triangular resonant cavity in vacuum proved that the PAAM meets the requirements.

The architecture of adaptive neural network based on a fuzzy inference system for implementing intelligent control in photovoltaic systems

NASA Astrophysics Data System (ADS)

Gimazov, R.; Shidlovskiy, S.

2018-05-01

In this paper, we consider the architecture of the algorithm for extreme regulation in the photovoltaic system. An algorithm based on an adaptive neural network with fuzzy inference is proposed. The implementation of such an algorithm not only allows solving a number of problems in existing algorithms for extreme power regulation of photovoltaic systems, but also creates a reserve for the creation of a universal control system for a photovoltaic system.

Antarctic Temperature Extremes from MODIS Land Surface Temperatures: New Processing Methods Reveal Data Quality Puzzles

NASA Astrophysics Data System (ADS)

Grant, G.; Gallaher, D. W.

2017-12-01

New methods for processing massive remotely sensed datasets are used to evaluate Antarctic land surface temperature (LST) extremes. Data from the MODIS/Terra sensor (Collection 6) provides a twice-daily look at Antarctic LSTs over a 17 year period, at a higher spatiotemporal resolution than past studies. Using a data condensation process that creates databases of anomalous values, our processes create statistical images of Antarctic LSTs. In general, the results find few significant trends in extremes; however, they do reveal a puzzling picture of inconsistent cloud detection and possible systemic errors, perhaps due to viewing geometry. Cloud discrimination shows a distinct jump in clear-sky detections starting in 2011, and LSTs around the South Pole exhibit a circular cooling pattern, which may also be related to cloud contamination. Possible root causes are discussed. Ongoing investigations seek to determine whether the results are a natural phenomenon or, as seems likely, the results of sensor degradation or processing artefacts. If the unusual LST patterns or cloud detection discontinuities are natural, they point to new, interesting processes on the Antarctic continent. If the data artefacts are artificial, MODIS LST users should be alerted to the potential issues.

MDCT in the evaluation of skeletal trauma: principles, protocols, and clinical applications.

PubMed

Geijer, Mats; El-Khoury, Georges Y

2006-10-01

Multidetector computed tomography (MDCT) scanners have made volume imaging possible and are used extensively to study polytrauma patients, especially in the evaluation of the spine and peripheral skeleton. An MDCT scanner coupled with a modern workstation has become an essential diagnostic tool for any emergency department. Familiarity with the basic physical principles of MDCT such as projection data, section collimation, and beam collimation is important to achieve high-quality imaging while keeping unnecessary radiation to a minimum. After a polytrauma MDCT examination, images can be reconstructed to obtain different slice thickness, slice interval, fields of view, or reconstruction kernels. No additional scanning is needed for imaging the thoracolumbar spine or bony pelvis. High-quality multiplanar reformation (MPR) and three-dimensional (3-D) images can be created at the workstation using the volumetric data. However, MDCT is a high-dose examination, and care should be taken to use as low a dose as possible. In the musculoskeletal system, MDCT has long been used for evaluation of spinal and pelvic trauma; however, the frequency of its use in extremity trauma has been low. In the extremities, radiography seems to underestimate the extent and severity of injury, especially in complex areas such as the shoulder, elbow, wrist, knee, and ankle. MDCT in the extremities is helpful in fracture detection, evaluation, characterization, and treatment planning. The MPR images give excellent structural detail, and the 3-D images help in understanding the spatial relations, which is important for fracture classification and for preoperative planning. MDCT is also helpful in the follow-up of postoperative results, even in the presence of hardware. Tendon injuries can also be evaluated with MDCT.

Mortality gradients within and among dominant plant populations as barometers of ecosystem change during extreme drought.

PubMed

Gitlin, Alicyn R; Sthultz, Christopher M; Bowker, Matthew A; Stumpf, Stacy; Paxton, Kristina L; Kennedy, Karla; Muñoz, Axhel; Bailey, Joseph K; Whitham, Thomas G

2006-10-01

Understanding patterns of plant population mortality during extreme weather events is important to conservation planners because the frequency of such events is expected to increase, creating the need to integrate climatic uncertainty into management. Dominant plants provide habitat and ecosystem structure, so changes in their distribution can be expected to have cascading effects on entire communities. Observing areas that respond quickly to climate fluctuations provides foresight into future ecological changes and will help prioritize conservation efforts. We investigated patterns of mortality in six dominant plant species during a drought in the southwestern United States. We quantified population mortality for each species across its regional distribution and tested hypotheses to identify ecological stress gradients for each species. Our results revealed three major patterns: (1) dominant species from diverse habitat types (i.e., riparian, chaparral, and low- to high-elevation forests) exhibited significant mortality, indicating that the effects of drought were widespread; (2) average mortality differed among dominant species (one-seed juniper[Juniperus monosperma (Engelm.) Sarg.] 3.3%; manzanita[Arctostaphylos pungens Kunth], 14.6%; quaking aspen[Populus tremuloides Michx.], 15.4%; ponderosa pine[Pinus ponderosa P. & C. Lawson], 15.9%; Fremont cottonwood[Populus fremontii S. Wats.], 20.7%; and pinyon pine[Pinus edulis Engelm.], 41.4%); (3) all dominant species showed localized patterns of very high mortality (24-100%) consistent with water stress gradients. Land managers should plan for climatic uncertainty by promoting tree recruitment in rare habitat types, alleviating unnatural levels of competition on dominant plants, and conserving sites across water stress gradients. High-stress sites, such as those we examined, have conservation value as barometers of change and because they may harbor genotypes that are adapted to climatic extremes.

Rotational spectroscopy with an optical centrifuge.

PubMed

Korobenko, Aleksey; Milner, Alexander A; Hepburn, John W; Milner, Valery

2014-03-07

We demonstrate a new spectroscopic method for studying electronic transitions in molecules with extremely broad range of angular momentum. We employ an optical centrifuge to create narrow rotational wave packets in the ground electronic state of (16)O2. Using the technique of resonance-enhanced multi-photon ionization, we record the spectrum of multiple ro-vibrational transitions between X(3)Σg(-) and C(3)Πg electronic manifolds of oxygen. Direct control of rotational excitation, extending to rotational quantum numbers as high as N ≳ 120, enables us to interpret the complex structure of rotational spectra of C(3)Πg beyond thermally accessible levels.

Antarctic Air Visits Paranal — Opening New Science Windows

NASA Astrophysics Data System (ADS)

Kerber, F.; Kuntschner, H.; Querel, R. R.; van den Ancker, M.

2014-03-01

Extremely low humidity (precipitable water vapour [PWV] of ~ 0.1 mm) in the atmosphere above Paranal has been measured by a water vapour radiometer over a period of about 12 hours. PWV values < 0.2 mm are usually only found at very high altitude or in Antarctica. In fact a pocket of Antarctic air has been shown to be responsible for this phenomenon and it may occur a few times per year at Paranal. We highlight the science opportunities — created by new atmospheric windows — that arise in such conditions. The community is invited to provide feedback on how to make best use of low PWV with the VLT.

Clusters of poverty and disease emerge from feedbacks on an epidemiological network.

PubMed

Pluciński, Mateusz M; Ngonghala, Calistus N; Getz, Wayne M; Bonds, Matthew H

2013-03-06

The distribution of health conditions is characterized by extreme inequality. These disparities have been alternately attributed to disease ecology and the economics of poverty. Here, we provide a novel framework that integrates epidemiological and economic growth theory on an individual-based hierarchically structured network. Our model indicates that, under certain parameter regimes, feedbacks between disease ecology and economics create clusters of low income and high disease that can stably persist in populations that become otherwise predominantly rich and free of disease. Surprisingly, unlike traditional poverty trap models, these localized disease-driven poverty traps can arise despite homogeneity of parameters and evenly distributed initial economic conditions.

Lunar Simulation in the Lunar Dust Adhesion Bell Jar

NASA Technical Reports Server (NTRS)

Gaier, James R.; Sechkar, Edward A.

2007-01-01

The Lunar Dust Adhesion Bell Jar has been assembled at the NASA Glenn Research Center to provide a high fidelity lunar simulation facility to test the interactions of lunar dust and lunar dust simulant with candidate aerospace materials and coatings. It has a sophisticated design which enables it to treat dust in a way that will remove adsorbed gases and create a chemically reactive surface. It can simulate the vacuum, thermal, and radiation environments of the Moon, including proximate areas of illuminated heat and extremely cold shadow. It is expected to be a valuable tool in the development of dust repellant and cleaning technologies for lunar surface systems.

PLASMA DEVICE

DOEpatents

Baker, W.R.

1961-08-22

A device is described for establishing and maintaining a high-energy, rotational plasma for use as a fast discharge capacitor. A disc-shaped, current- conducting plasma is formed in an axinl magnetic field and a crossed electric field, thereby creating rotational kinetic enengy in the plasma. Such energy stored in the rotation of the plasma disc is substantial and is convertible tc electrical energy by generator action in an output line electrically coupled to the plasma volume. Means are then provided for discharging the electrical energy into an external circuit coupled to the output line to produce a very large pulse having an extremely rapid rise time in the waveform thereof. (AE C)

Increased frequency of extreme Indian Ocean Dipole events due to greenhouse warming.

PubMed

Cai, Wenju; Santoso, Agus; Wang, Guojian; Weller, Evan; Wu, Lixin; Ashok, Karumuri; Masumoto, Yukio; Yamagata, Toshio

2014-06-12

The Indian Ocean dipole is a prominent mode of coupled ocean-atmosphere variability, affecting the lives of millions of people in Indian Ocean rim countries. In its positive phase, sea surface temperatures are lower than normal off the Sumatra-Java coast, but higher in the western tropical Indian Ocean. During the extreme positive-IOD (pIOD) events of 1961, 1994 and 1997, the eastern cooling strengthened and extended westward along the equatorial Indian Ocean through strong reversal of both the mean westerly winds and the associated eastward-flowing upper ocean currents. This created anomalously dry conditions from the eastern to the central Indian Ocean along the Equator and atmospheric convergence farther west, leading to catastrophic floods in eastern tropical African countries but devastating droughts in eastern Indian Ocean rim countries. Despite these serious consequences, the response of pIOD events to greenhouse warming is unknown. Here, using an ensemble of climate models forced by a scenario of high greenhouse gas emissions (Representative Concentration Pathway 8.5), we project that the frequency of extreme pIOD events will increase by almost a factor of three, from one event every 17.3 years over the twentieth century to one event every 6.3 years over the twenty-first century. We find that a mean state change--with weakening of both equatorial westerly winds and eastward oceanic currents in association with a faster warming in the western than the eastern equatorial Indian Ocean--facilitates more frequent occurrences of wind and oceanic current reversal. This leads to more frequent extreme pIOD events, suggesting an increasing frequency of extreme climate and weather events in regions affected by the pIOD.

Alkaliphilic Bacteria with Impact on Industrial Applications, Concepts of Early Life Forms, and Bioenergetics of ATP Synthesis

PubMed Central

Preiss, Laura; Hicks, David B.; Suzuki, Shino; Meier, Thomas; Krulwich, Terry Ann

2015-01-01

Alkaliphilic bacteria typically grow well at pH 9, with the most extremophilic strains growing up to pH values as high as pH 12–13. Interest in extreme alkaliphiles arises because they are sources of useful, stable enzymes, and the cells themselves can be used for biotechnological and other applications at high pH. In addition, alkaline hydrothermal vents represent an early evolutionary niche for alkaliphiles and novel extreme alkaliphiles have also recently been found in alkaline serpentinizing sites. A third focus of interest in alkaliphiles is the challenge raised by the use of proton-coupled ATP synthases for oxidative phosphorylation by non-fermentative alkaliphiles. This creates a problem with respect to tenets of the chemiosmotic model that remains the core model for the bioenergetics of oxidative phosphorylation. Each of these facets of alkaliphilic bacteria will be discussed with a focus on extremely alkaliphilic Bacillus strains. These alkaliphilic bacteria have provided a cogent experimental system to probe adaptations that enable their growth and oxidative phosphorylation at high pH. Adaptations are clearly needed to enable secreted or partially exposed enzymes or protein complexes to function at the high external pH. Also, alkaliphiles must maintain a cytoplasmic pH that is significantly lower than the pH of the outside medium. This protects cytoplasmic components from an external pH that is alkaline enough to impair their stability or function. However, the pH gradient across the cytoplasmic membrane, with its orientation of more acidic inside than outside, is in the reverse of the productive orientation for bioenergetic work. The reversed gradient reduces the trans-membrane proton-motive force available to energize ATP synthesis. Multiple strategies are hypothesized to be involved in enabling alkaliphiles to circumvent the challenge of a low bulk proton-motive force energizing proton-coupled ATP synthesis at high pH. PMID:26090360

A New High Resolution Climate Dataset for Climate Change Impacts Assessments in New England

NASA Astrophysics Data System (ADS)

Komurcu, M.; Huber, M.

2016-12-01

Assessing regional impacts of climate change (such as changes in extreme events, land surface hydrology, water resources, energy, ecosystems and economy) requires much higher resolution climate variables than those available from global model projections. While it is possible to run global models in higher resolution, the high computational cost associated with these simulations prevent their use in such manner. To alleviate this problem, dynamical downscaling offers a method to deliver higher resolution climate variables. As part of an NSF EPSCoR funded interdisciplinary effort to assess climate change impacts on New Hampshire ecosystems, hydrology and economy (the New Hampshire Ecosystems and Society project), we create a unique high-resolution climate dataset for New England. We dynamically downscale global model projections under a high impact emissions scenario using the Weather Research and Forecasting model (WRF) with three nested grids of 27, 9 and 3 km horizontal resolution with the highest resolution innermost grid focusing over New England. We prefer dynamical downscaling over other methods such as statistical downscaling because it employs physical equations to progressively simulate climate variables as atmospheric processes interact with surface processes, emissions, radiation, clouds, precipitation and other model components, hence eliminates fix relationships between variables. In addition to simulating mean changes in regional climate, dynamical downscaling also allows for the simulation of climate extremes that significantly alter climate change impacts. We simulate three time slices: 2006-2015, 2040-2060 and 2080-2100. This new high-resolution climate dataset (with more than 200 variables saved in hourly (six hourly) intervals for the highest resolution domain (outer two domains)) along with model input and restart files used in our WRF simulations will be publicly available for use to the broader scientific community to support in-depth climate change impacts assessments for New England. We present results focusing on future changes in New England extreme events.

Flight Avionics Hardware Roadmap

NASA Technical Reports Server (NTRS)

Some, Raphael; Goforth, Monte; Chen, Yuan; Powell, Wes; Paulick, Paul; Vitalpur, Sharada; Buscher, Deborah; Wade, Ray; West, John; Redifer, Matt;

Alkaliphilic Bacteria with Impact on Industrial Applications, Concepts of Early Life Forms, and Bioenergetics of ATP Synthesis.

PubMed

Preiss, Laura; Hicks, David B; Suzuki, Shino; Meier, Thomas; Krulwich, Terry Ann

2015-01-01

Alkaliphilic bacteria typically grow well at pH 9, with the most extremophilic strains growing up to pH values as high as pH 12-13. Interest in extreme alkaliphiles arises because they are sources of useful, stable enzymes, and the cells themselves can be used for biotechnological and other applications at high pH. In addition, alkaline hydrothermal vents represent an early evolutionary niche for alkaliphiles and novel extreme alkaliphiles have also recently been found in alkaline serpentinizing sites. A third focus of interest in alkaliphiles is the challenge raised by the use of proton-coupled ATP synthases for oxidative phosphorylation by non-fermentative alkaliphiles. This creates a problem with respect to tenets of the chemiosmotic model that remains the core model for the bioenergetics of oxidative phosphorylation. Each of these facets of alkaliphilic bacteria will be discussed with a focus on extremely alkaliphilic Bacillus strains. These alkaliphilic bacteria have provided a cogent experimental system to probe adaptations that enable their growth and oxidative phosphorylation at high pH. Adaptations are clearly needed to enable secreted or partially exposed enzymes or protein complexes to function at the high external pH. Also, alkaliphiles must maintain a cytoplasmic pH that is significantly lower than the pH of the outside medium. This protects cytoplasmic components from an external pH that is alkaline enough to impair their stability or function. However, the pH gradient across the cytoplasmic membrane, with its orientation of more acidic inside than outside, is in the reverse of the productive orientation for bioenergetic work. The reversed gradient reduces the trans-membrane proton-motive force available to energize ATP synthesis. Multiple strategies are hypothesized to be involved in enabling alkaliphiles to circumvent the challenge of a low bulk proton-motive force energizing proton-coupled ATP synthesis at high pH.

[Multi-temporal scale analysis of impacts of extreme high temperature on net carbon uptake in subtropical coniferous plantation.

PubMed

Zhang, Mi; Wen, Xue Fa; Zhang, Lei Ming; Wang, Hui Min; Guo, Yi Wen; Yu, Gui Rui

2018-02-01

Extreme high temperature is one of important extreme weathers that impact forest ecosystem carbon cycle. In this study, applying CO 2 flux and routine meteorological data measured during 2003-2012, we examined the impacts of extreme high temperature and extreme high temperature event on net carbon uptake of subtropical coniferous plantation in Qianyanzhou. Combining with wavelet analysis, we analyzed environmental controls on net carbon uptake at different temporal scales, when the extreme high temperature and extreme high temperature event happened. The results showed that mean daily cumulative NEE decreased by 51% in the days with daily maximum air temperature range between 35 ℃ and 40 ℃, compared with that in the days with the range between 30 ℃ and 34 ℃. The effects of the extreme high temperature and extreme high temperature event on monthly NEE and annual NEE related to the strength and duration of extreme high tempe-rature event. In 2003, when strong extreme high temperature event happened, the sum of monthly cumulative NEE in July and August was only -11.64 g C·m -2 ·(2 month) -1 . The value decreased by 90%, compared with multi-year average value. At the same time, the relative variation of annual NEE reached -6.7%. In July and August, when the extreme high temperature and extreme high temperature event occurred, air temperature (T a ) and vapor press deficit (VPD) were the dominant controller for the daily variation of NEE. The coherency between NEE T a and NEE VPD was 0.97 and 0.95, respectively. At 8-, 16-, and 32-day periods, T a , VPD, soil water content at 5 cm depth (SWC), and precipitation (P) controlled NEE. The coherency between NEE SWC and NEE P was higher than 0.8 at monthly scale. The results indicated that atmospheric water deficit impacted NEE at short temporal scale, when the extreme high temperature and extreme high temperature event occurred, both of atmospheric water deficit and soil drought stress impacted NEE at long temporal scales in this ecosystem.

Highly Stretchable Fully-Printed CNT-Based Electrochemical Sensors and Biofuel Cells: Combining Intrinsic and Design-Induced Stretchability.

PubMed

Bandodkar, Amay J; Jeerapan, Itthipon; You, Jung-Min; Nuñez-Flores, Rogelio; Wang, Joseph

2016-01-13

We present the first example of an all-printed, inexpensive, highly stretchable CNT-based electrochemical sensor and biofuel cell array. The synergistic effect of utilizing specially tailored screen printable stretchable inks that combine the attractive electrical and mechanical properties of CNTs with the elastomeric properties of polyurethane as a binder along with a judiciously designed free-standing serpentine pattern enables the printed device to possess two degrees of stretchability. Owing to these synergistic design and nanomaterial-based ink effects, the device withstands extremely large levels of strains (up to 500% strain) with negligible effect on its structural integrity and performance. This represents the highest stretchability offered by a printed device reported to date. Extensive electrochemical characterization of the printed device reveal that repeated stretching, torsional twisting, and indenting stress has negligible impact on its electrochemical properties. The wide-range applicability of this platform to realize highly stretchable CNT-based electrochemical sensors and biofuel cells has been demonstrated by fabricating and characterizing potentiometric ammonium sensor, amperometric enzyme-based glucose sensor, enzymatic glucose biofuel cell, and self-powered biosensor. Highly stretchable printable multianalyte sensor, multifuel biofuel cell, or any combination thereof can thus be realized using the printed CNT array. Such combination of intrinsically stretchable printed nanomaterial-based electrodes and strain-enduring design patterns holds considerable promise for creating an attractive class of inexpensive multifunctional, highly stretchable printed devices that satisfy the requirements of diverse healthcare and energy fields wherein resilience toward extreme mechanical deformations is mandatory.

Pressure wave injuries to rat dorsal root ganglion cells in culture caused by high-energy missiles.

PubMed

Suneson, A; Hansson, H A; Lycke, E; Seeman, T

1989-01-01

A high-energy missile impact in an extremity of an animal creates a shock wave which is rapidly dispersed as a burst of oscillating pressure waves that traverses the entire body causing local, regional, and distant injuries. The present study was performed on dorsal root ganglion (DRG) cells, cultured for 3 weeks, to elucidate the cellular mechanism for damage of nerve cells, using a simplified test system. A model system was developed allowing exposure of DRG cultures to a burst of high-frequency oscillating pressure waves, comparable to those recorded in animals after high-energy missile extremity impact. The pressure waves were induced by impact of a high-energy missile in a rubber tube filled with water, in which nerve cell cultures were kept in a closed rubber glove filled with tissue culture medium. The pressure waves had a duration of 0.5-1.5 ms and a frequency spectrum ranging from 0-250 kHz. Within minutes the neurites showed changes in their microtubules. In addition, varicosities, enriched with tubulin immunoreactive material, became irregularly studded along the nerve cell processes. Scattered DRG cells were initially permeable to the marker complex Evans-blue albumin (EBA), used as an indicator of the ability of the plasma membranes to exclude proteins. After 6 hr, however, almost every DRG neuron was intensely stained by EBA. Concomitantly, there was swelling of the nerve cell cytoplasm and organelles, and, to a variable extent, neurofilament tangles were observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Modeling The Atmosphere In The Era Of Big Data From Extremely Wide Field-Of-View Telescopes

NASA Astrophysics Data System (ADS)

Gonzalez Quiles, Junellie; Nordin, Jakob

2018-01-01

Surveys like the Sloan Digital Sky Survey (SDSS), Pan-STARRS and the Palomar Transient Factory Survey (PTF) receive large amounts of data, which need to be processed and calibrated in order to correct for various factors. One of the limiting factors in obtaining high quality data is the atmosphere, and it is therefore essential to find the appropriate calibration for the atmospheric extinction. It is to be expected that a physical atmospheric model, compared to a photometric calibration used currently by PTF, is more effective in calibrating for the atmospheric extinction due to its ability to account for rapid atmospheric fluctuation and objects of different colors. We focused on creating tools to model the atmospheric extinction for the upcoming Zwicky Transient Factory Survey (ZTF). In order to model the atmosphere, we created a program that combines input data and catalogue values, and efficiently handles them. Then, using PTF data and the SDSS catalogue, we created several models to fit the data, and tested the quality of the fits by chi-square minimization. This will allow us to optimize atmospheric extinction for the upcoming ZTF in the near future.

Estimation, modeling, and simulation of patterned growth in extreme environments.

PubMed

Strader, B; Schubert, K E; Quintana, M; Gomez, E; Curnutt, J; Boston, P

2011-01-01

In the search for life on Mars and other extraterrestrial bodies or in our attempts to identify biological traces in the most ancient rock record of Earth, one of the biggest problems facing us is how to recognize life or the remains of ancient life in a context very different from our planet's modern biological examples. Specific chemistries or biological properties may well be inapplicable to extraterrestrial conditions or ancient Earth environments. Thus, we need to develop an arsenal of techniques that are of broader applicability. The notion of patterning created in some fashion by biological processes and properties may provide such a generalized property of biological systems no matter what the incidentals of chemistry or environmental conditions. One approach to recognizing these kinds of patterns is to look at apparently organized arrangements created and left by life in extreme environments here on Earth, especially at various spatial scales, different geologies, and biogeochemical circumstances.

Extremely frequent behavior in consumer research: theory and empirical evidence for chronic casino gambling.

PubMed

Perfetto, Ralph; Woodside, Arch G

2009-09-01

The present study informs understanding of customer segmentation strategies by extending Twedt's heavy-half propositions to include a segment of users that represent less than 2% of all households-consumers demonstrating extremely frequent behavior (EFB). Extremely frequent behavior (EFB) theory provides testable propositions relating to the observation that few (2%) consumers in many product and service categories constitute more than 25% of the frequency of product or service use. Using casino gambling as an example for testing EFB theory, an analysis of national survey data shows that extremely frequent casino gamblers do exist and that less than 2% of all casino gamblers are responsible for nearly 25% of all casino gambling usage. Approximately 14% of extremely frequent casino users have very low-household income, suggesting somewhat paradoxical consumption patterns (where do very low-income users find the money to gamble so frequently?). Understanding the differences light, heavy, and extreme users and non-users can help marketers and policymakers identify and exploit "blue ocean" opportunities (Kim and Mauborgne, Blue ocean strategy, Harvard Business School Press, Boston, 2005), for example, creating effective strategies to convert extreme users into non-users or non-users into new users.

Operative Treatment of Lymphedema Using Suction-Assisted Lipectomy.

PubMed

Greene, Arin K; Maclellan, Reid A

2016-09-01

Surgical management of lymphedema includes removal of affected tissues (excisional procedures), or operations that create new lymphatic connections (physiologic procedures). The purpose of this study was to determine the efficacy of one type of excisional procedure, suction-assisted lipectomy, for extremity lymphedema. Patients treated in our Lymphedema Program between 2007 and 2015 with liposuction that had postoperative follow-up were reviewed. The diagnosis of lymphedema was made by history/physical examination and confirmed with lymphoscintigraphy. Patient sex, age, type of lymphedema (primary or secondary), location of disease, infection history, volume of lipoaspirate, and reduction of extremity volume were recorded. Fifteen patients were included, mean age was 45 years (range, 17-71). Six patients had secondary upper extremity lymphedema, and 9 patients had lower limb disease. Eight patients had a history of repeated cellulitis involving the lymphedematous extremity. Mean lipoaspirate volume was 1612 mL (range, 1200-2800) for the upper extremity and 2902 mL (range, 2000-4800) for the lower limb. Postoperative follow-up averaged 3.1 years. The mean reduction in excess extremity volume was 73% (range, 48% to 94%), and patients reported improvement in their quality of life. Suction-assisted lipectomy is an effective technique to reduce extremity volume for patients with lymphedema.

Manipulation of Samples at Extreme Temperatures for Fast in-situ Synchrotron Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, Richard

An aerodynamic sample levitation system with laser beam heating was integrated with the APS beamlines 6 ID-D, 11 ID-C and 20 BM-B. The new capability enables in-situ measurements of structure and XANES at extreme temperatures (300-3500 °C) and in conditions that completely avoid contact with container surfaces. In addition to maintaining a high degree of sample purity, the use of aerodynamic levitation enables deep supercooling and greatly enhanced glass formation from a wide variety of melts and liquids. Development and integration of controlled extreme sample environments and new measurement techniques is an important aspect of beamline operations and user support.more » Processing and solidifying liquids is a critical value-adding step in manufacturing semiconductors, optical materials, metals and in the operation of many energy conversion devices. Understanding structural evolution is of fundamental importance in condensed materials, geology, and biology. The new capability provides unique possibilities for materials research and helps to develop and maintain a competitive materials manufacturing and energy utilization industry. Test samples were used to demonstrate key features of the capability including experiments on hot crystalline materials, liquids at temperatures from about 500 to 3500 °C. The use of controlled atmospheres using redox gas mixtures enabled in-situ changes in the oxidation states of cations in melts. Significant innovations in this work were: (i) Use of redox gas mixtures to adjust the oxidation state of cations in-situ (ii) Operation with a fully enclosed system suitable for work with nuclear fuel materials (iii) Making high quality high energy in-situ x-ray diffraction measurements (iv) Making high quality in-situ XANES measurements (v) Publishing high impact results (vi) Developing independent funding for the research on nuclear materials This SBIR project work led to a commercial instrument product for the niche market of processing and studying materials in extreme conditions. MDI registered the trademark “Instruments for Innovation®” and sells products under this trademark. SBIR is the ideal vehicle for funding developments such as this since the total market size is relatively small meaning that venture investments to develop products cannot typically be obtained. The sale of niche market instruments for work in extreme conditions has been several million dollars over the last decade. The work to develop and build and sell this instrument has created stable high paying jobs in the technology manufacturing sector. Outreach enabled by this research helped with PhD thesis research, supported three undergraduate interns and one local high school student. In addition, several scientific articles were published, papers were presented at international conferences, and a workshop was held.« less

Prevention through policy: Urban macroplastic leakages to the marine environment during extreme rainfall events.

PubMed

Axelsson, Charles; van Sebille, Erik

2017-11-15

The leakage of large plastic litter (macroplastics) into the ocean is a major environmental problem. A significant fraction of this leakage originates from coastal cities, particularly during extreme rainfall events. As coastal cities continue to grow, finding ways to reduce this macroplastic leakage is extremely pertinent. Here, we explore why and how coastal cities can reduce macroplastic leakages during extreme rainfall events. Using nine global cities as a basis, we establish that while cities actively create policies that reduce plastic leakages, more needs to be done. Nonetheless, these policies are economically, socially and environmentally cobeneficial to the city environment. While the lack of political engagement and economic concerns limit these policies, lacking social motivation and engagement is the largest limitation towards implementing policy. We recommend cities to incentivize citizen and municipal engagement with responsible usage of plastics, cleaning the environment and preparing for future extreme rainfall events. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Statistical analysis and ANN modeling for predicting hydrological extremes under climate change scenarios: the example of a small Mediterranean agro-watershed.

PubMed

Kourgialas, Nektarios N; Dokou, Zoi; Karatzas, George P

2015-05-01

The purpose of this study was to create a modeling management tool for the simulation of extreme flow events under current and future climatic conditions. This tool is a combination of different components and can be applied in complex hydrogeological river basins, where frequent flood and drought phenomena occur. The first component is the statistical analysis of the available hydro-meteorological data. Specifically, principal components analysis was performed in order to quantify the importance of the hydro-meteorological parameters that affect the generation of extreme events. The second component is a prediction-forecasting artificial neural network (ANN) model that simulates, accurately and efficiently, river flow on an hourly basis. This model is based on a methodology that attempts to resolve a very difficult problem related to the accurate estimation of extreme flows. For this purpose, the available measurements (5 years of hourly data) were divided in two subsets: one for the dry and one for the wet periods of the hydrological year. This way, two ANNs were created, trained, tested and validated for a complex Mediterranean river basin in Crete, Greece. As part of the second management component a statistical downscaling tool was used for the creation of meteorological data according to the higher and lower emission climate change scenarios A2 and B1. These data are used as input in the ANN for the forecasting of river flow for the next two decades. The final component is the application of a meteorological index on the measured and forecasted precipitation and flow data, in order to assess the severity and duration of extreme events. Copyright © 2015 Elsevier Ltd. All rights reserved.

Dense Plasma Focus: physics and applications (radiation material science, single-shot disclosure of hidden illegal objects, radiation biology and medicine, etc.)

NASA Astrophysics Data System (ADS)

Gribkov, V. A.; Miklaszewski, R.; Paduch, M.; Zielinska, E.; Chernyshova, M.; Pisarczyk, T.; Pimenov, V. N.; Demina, E. V.; Niemela, J.; Crespo, M.-L.; Cicuttin, A.; Tomaszewski, K.; Sadowski, M. J.; Skladnik-Sadowska, E.; Pytel, K.; Zawadka, A.; Giannini, G.; Longo, F.; Talab, A.; Ul'yanenko, S. E.

2015-03-01

The paper presents some outcomes obtained during the year of 2013 of the activity in the frame of the International Atomic Energy Agency Co-ordinated research project "Investigations of Materials under High Repetition and Intense Fusion-Relevant Pulses". The main results are related to the effects created at the interaction of powerful pulses of different types of radiation (soft and hard X-rays, hot plasma and fast ion streams, neutrons, etc. generated in Dense Plasma Focus (DPF) facilities) with various materials including those that are counted as perspective ones for their use in future thermonuclear reactors. Besides we discuss phenomena observed at the irradiation of biological test objects. We examine possible applications of nanosecond powerful pulses of neutrons to the aims of nuclear medicine and for disclosure of hidden illegal objects. Special attention is devoted to discussions of a possibility to create extremely large and enormously diminutive DPF devices and probabilities of their use in energetics, medicine and modern electronics.

Directed Nanopatterning with Nonlinear Laser Lithography

NASA Astrophysics Data System (ADS)

Tokel, Onur; Yavuz, Ozgun; Ergecen, Emre; Pavlov, Ihor; Makey, Ghaith; Ilday, Fatih Omer

In spite of the successes of maskless optical nanopatterning methods, it remains extremely challenging to create any isotropic, periodic nanopattern. Further, available optical techniques lack the long-range coverage and high periodicity demanded by photonics and photovoltaics applications. Here, we provide a novel solution with Nonlinear Laser Lithography (NLL) approach. Notably, we demonstrate that self-organized nanopatterns can be produced in all possible Bravais lattice types. Further, we show that carefully chosen defects or structued noise can direct NLL symmetries. Exploitation of directed self-organizatio to select or guide to predetermined symmetries is a new capability. Predictive capabilities for such far-from-equilibrium, dissipative systems is very limited due to a lack of experimental systems with predictive models. Here we also present a completely predictive model, and experimentally confirm that the emergence of motifs can be regulated by engineering defects, while the polarization of the ultrafast laser prescribes lattice symmetry, which in turn reinforces translational invariance. Thus, NLL enables a novel, maskless nanofabrication approach, where laser-induced nanopatterns can be rapidly created in any lattice symmetry

Communication: A novel method for generating molecular mixtures at extreme conditions: The case of hydrogen and oxygen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pravica, Michael; Sneed, Daniel; White, Melanie

2014-09-07

We have created a segregated mixture of molecular fluorine and oxygen at high pressure in a diamond anvil cell (DAC) via useful hard x-ray photochemistry. Here, a keyhole-like sample chamber was created in a stainless steel gasket to hold two segregated powders of potassium tetrafluoroborate (KBF 4) and potassium perchlorate (KClO 4) respectively in each hole at a pressure of ~3.0 GPa. Both holes were individually irradiated with synchrotron hard x-rays to release molecular fluorine and molecular oxygen, respectively. Upon irradiation of the hole containing KBF 4 molecular fluorine appeared (as evidenced via Raman spectroscopy) near the region of irradiation.more » The second hole containing KClO 4 was then irradiated and reddish-orange O 2 was observed to form. Oxygen was observed to diffuse throughout both holes whereas molecular fluorine did not. There is some evidence that oxygen difluoride (OF 2) was formed in the hole originally containing the KBF 4.« less

Uplift of Ionospheric Oxygen Ions During Extreme Magnetic Storms

NASA Technical Reports Server (NTRS)

Tsurutani, Bruce T.; Mannucci, Anthony J.; Verkhoglyadova, Olga P.; Huba, Joseph; Lakhina, Gurbax S.

2013-01-01

Research reported earlier in literature was conducted relating to estimation of the ionospheric electrical field, which may have occurred during the September 1859 Carrington geomagnetic storm event, with regard to modern-day consequences. In this research, the NRL SAMI2 ionospheric code has been modified and applied the estimated electric field to the dayside ionosphere. The modeling was done at 15-minute time increments to track the general ionospheric changes. Although it has been known that magnetospheric electric fields get down into the ionosphere, it has been only in the last ten years that scientists have discovered that intense magnetic storm electric fields do also. On the dayside, these dawn-to-dusk directed electric fields lift the plasma (electrons and ions) up to higher altitudes and latitudes. As plasma is removed from lower altitudes, solar UV creates new plasma, so the total plasma in the ionosphere is increased several-fold. Thus, this complex process creates super-dense plasmas at high altitudes (from 700 to 1,000 km and higher).

Creating the electric energy mix of a non-connected Aegean island

NASA Astrophysics Data System (ADS)

Stamou, Paraskevi; Karali, Sophia; Chalakatevaki, Maria; Daniil, Vasiliki; Tzouka, Katerina; Dimitriadis, Panayiotis; Iliopoulou, Theano; Papanicolaou, Panos; Koutsoyiannis, Demetris; Mamasis, Nikos

2017-04-01

As the electric energy in the non-connected islands is mainly produced by oil-fueled power plants, the unit cost is extremely high. Here the various energy sources are examined in order to create the appropriate electric energy mix for a non-connected Aegean island. All energy sources (renewable and fossil fuels) are examined and each one is evaluated using technical, environmental and economic criteria. Finally the most appropriate energy sources are simulated considering the corresponding energy works. Special emphasis is given to the use of biomass and the possibility of replacing (even partially) the existing oil-fueled power plant. Finally, a synthesis of various energy sources is presented that satisfies the electric energy demand taking into account the base and peak electric loads of the island. Acknowledgement: This research is conducted within the frame of the undergraduate course "Stochastic Methods in Water Resources" of the National Technical University of Athens (NTUA). The School of Civil Engineering of NTUA provided moral support for the participation of the students in the Assembly.

Home programs for upper extremity recovery post-stroke: a survey of occupational therapy practitioners.

PubMed

Donoso Brown, Elena V; Fichter, Renae

2017-12-01

Upper extremity hemiparesis is an impairment post-stroke that impacts quality of life. Home programs are an intervention strategy used by many occupational therapists to support continued motor recovery post-stroke, yet little is known about how these programs are designed and implemented. The purpose of this study was to describe how occupational therapy practitioners approach this task and specifically what strategies they use to support adherence and what types of technology are most commonly used. An on-line survey methodology was used. Participants were recruited through multiple sources including state associations and occupational therapy educational program directors. A total of 73 occupational therapy practitioners submitted complete surveys. It was found that majority of occupational therapy practitioners in the sample (n = 53) reported creating home programs focused on upper extremity motor recovery more than 80% of the time. Range of motion and strengthening were reported as being in the top three most commonly used interventions by more than half the sample, however incorporating clients' goals and interests were reported most often as strategies to create meaning in the home program. Respondents also reported limited incorporation of technology and strategies to support adherence. Personal motivation was reported by occupational therapy practitioners to be a key moderator of adherence to a home program. Occupational therapy practitioners often provide home programs for individuals post-stroke focusing on upper extremity function. Future research that aims to understand stakeholders' perspectives on home programs and determine effective strategies for ensuring adherence is needed.

Intraseasonal Cold Air Outbreak over East Asia and the preceding atmospheric condition over the Barents-Kara Sea

NASA Astrophysics Data System (ADS)

Hori, M. E.; Inoue, J.

2011-12-01

Frequent occurrence of cold air outbreak is a dominant feature of the East Asian winter monsoon. A contributing factor for the this cold air outbreak is the role of stationary Rossby waves over the Eurasian continent which intensifies the surface Siberian High and the accompanying cold air outflow. Reduced sea ice and increase in turbulence heat flux is hypothesized as a source of such stationary waves (Honda et al. 2009). In particular, the winter of 2009/2010 saw a strong correlation of high pressure anomaly over the Barents/Kara sea and the following cold air buildup over the Eurasian continent and its advection towards East Asia (Hori et al. 2011). The lag correlation of surface temperature over Japan and the 850hPa geopotential height shows a cyclonic anomaly appearing over the Barents/Kara sea which creates a cold air advection over the Eurasian continent. The pressure anomaly subsequently shifted westward to mature into a blocking high which created a wave- train pattern downstream advecting the cold air buildup eastward toward East Asia and Japan (Fig1). We further examine this mechanism for other years including the 2005/2006, 2010/2011 winter and other winters with extreme cold air outbreaks. Overall, the existence of an anticyclonic anomaly over the Barents/Kara sea correlated well with the seasonal dominance of cold air over the Eurasian continent thereby creating a contrast of a warm Arctic and cold Eurasian continent.In the intraseasonal timescale, the existence of this anticyclone corresponds to a persisting atmospheric blocking in the high latitudes. In the presentation, we address the underlying chain of events leading up to a strong cold air outbreak over East Asia from an atmosphere - sea ice - land surafce interaction point of view for paritular cold winter years.

Silicon-Germanium Voltage-Controlled Oscillator at 105 GHz

NASA Technical Reports Server (NTRS)

Wong, Alden; Larocca, Tim; Chang, M. Frank; Samoska, Lorene A.

2011-01-01

A group at UCLA, in collaboration with the Jet Propulsion Laboratory, has designed a voltage-controlled oscillator (VCO) created specifically for a compact, integrated, electronically tunable frequency generator useable for submillimeter- wave science instruments operating in extreme cold environments.

EXPOSURE ASSESSMENT MODELING FOR HYDROCARBON SPILLS INTO THE SUBSURFACE

EPA Science Inventory

Hydrocarbons which enter the subsurface through spills or leaks may create serious, long-lived ground-water contamination problems. onventional finite difference and finite element models of multiphase, multicomponent flow often have extreme requirements for both computer time an...

Bright and durable field-emission source derived from frozen refractory-metal Taylor cones

DOE PAGES

Hirsch, Gregory

2017-02-22

A novel method for creating conical field-emission structures possessing unusual and desirable physical characteristics is described. This process is accomplished by solidification of electrostatically formed high-temperature Taylor cones created on the ends of laser melted refractory-metal wires. Extremely rapid freezing ensures that the resultant solid structures preserve the shape and surface smoothness of the flawless liquid Taylor-cones to a very high degree. The method also enables in situ and rapid restoration of the frozen cones to their initial pristine state after undergoing physical degradation during use. This permits maximum current to be delivered without excessive concern for any associated reductionmore » in field-emitter lifetime resulting from operation near or even above the damage threshold. In addition to the production of field emitters using polycrystalline wires as a substrate, the feasibility of producing monocrystalline frozen Taylor-cones having reproducible crystal orientation by growth on single-crystal wires was demonstrated. Finally, the development of the basic field-emission technology, progress to incorporate it into a pulsed electron gun employing laser-assisted field emission for ultrafast experiments, and some additional advances and opportunities are discussed.« less

Biogeochemical cycling in the Ross Sea: An introduction

NASA Astrophysics Data System (ADS)

Marra, John

1996-08-01

Twenty or 30 years ago, interest in the Southern Ocean was largely driven by its exceptional characteristics. The Southern Ocean was such an anomaly, with extremes of productivity (thought to be high), nutrients (also high), temperatures (low), populations of krill and whales, and, of course, the presence of ice. There was also created, perhaps, an allure because of its distance and because it was so unusual, relative to the familiarity of the North Atlantic, for example. It has turned out, not surprisingly, that these exceptional characteristics illustrate the exceptional importance of the Southern Ocean to global ocean phenomena. By virtue of creating water masses the Southern Ocean may play a significant role in the ocean's nutrient distributions. Low temperatures over large areas mean that, potentially, it is a significant sink for dissolved gases such as oxygen and carbon dioxide. It is generally believed that Antarctica (as well as the Arctic) may be more susceptible to climate change than either temperate or tropical ecosystems, because these ecosystems function within a few degrees of the freezing point of water. Altogether, the processes here will tell us much about how the ocean works today and in the distant past.

Bright and durable field-emission source derived from frozen refractory-metal Taylor cones

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirsch, Gregory

A novel method for creating conical field-emission structures possessing unusual and desirable physical characteristics is described. This process is accomplished by solidification of electrostatically formed high-temperature Taylor cones created on the ends of laser melted refractory-metal wires. Extremely rapid freezing ensures that the resultant solid structures preserve the shape and surface smoothness of the flawless liquid Taylor-cones to a very high degree. The method also enables in situ and rapid restoration of the frozen cones to their initial pristine state after undergoing physical degradation during use. This permits maximum current to be delivered without excessive concern for any associated reductionmore » in field-emitter lifetime resulting from operation near or even above the damage threshold. In addition to the production of field emitters using polycrystalline wires as a substrate, the feasibility of producing monocrystalline frozen Taylor-cones having reproducible crystal orientation by growth on single-crystal wires was demonstrated. Finally, the development of the basic field-emission technology, progress to incorporate it into a pulsed electron gun employing laser-assisted field emission for ultrafast experiments, and some additional advances and opportunities are discussed.« less

ACCELERATED EVOLUTION OF LAND SNAILS MANDARINA IN THE OCEANIC BONIN ISLANDS: EVIDENCE FROM MITOCHONDRIAL DNA SEQUENCES.

PubMed

Chiba, Satoshi

1999-04-01

An endemic land snail genus Mandarina of the oceanic Bonin (Ogasawara) Islands shows exceptionally rapid evolution not only of morphological and ecological traits, but of DNA sequence. A phylogenetic relationship based on mitochondrial DNA (mtDNA) sequences suggests that morphological differences equivalent to the differences between families were produced between Mandarina and its ancestor during the Pleistocene. The inferred phylogeny shows that species with similar morphologies and life habitats appeared repeatedly and independently in different lineages and islands at different times. Sequential adaptive radiations occurred in different islands of the Bonin Islands and species occupying arboreal, semiarboreal, and terrestrial habitat arose independently in each island. Because of a close relationship between shell morphology and life habitat, independent evolution of the same life habitat in different islands created species possesing the same shell morphology in different islands and lineages. This rapid evolution produced some incongruences between phylogenetic relationship and species taxonomy. Levels of sequence divergence of mtDNA among the species of Mandarina is extremely high. The maximum level of sequence divergence at 16S and 12S ribosomal RNA sequence within Mandarina are 18.7% and 17.7%, respectively, and this suggests that evolution of mtDNA of Mandarina is extremely rapid, more than 20 times faster than the standard rate in other animals. The present examination reveals that evolution of morphological and ecological traits occurs at extremely high rates in the time of adaptive radiation, especially in fragmented environments. © 1999 The Society for the Study of Evolution.

High thermal conductivity in soft elastomers with elongated liquid metal inclusions.

PubMed

Bartlett, Michael D; Kazem, Navid; Powell-Palm, Matthew J; Huang, Xiaonan; Sun, Wenhuan; Malen, Jonathan A; Majidi, Carmel

2017-02-28

Soft dielectric materials typically exhibit poor heat transfer properties due to the dynamics of phonon transport, which constrain thermal conductivity ( k ) to decrease monotonically with decreasing elastic modulus ( E ). This thermal-mechanical trade-off is limiting for wearable computing, soft robotics, and other emerging applications that require materials with both high thermal conductivity and low mechanical stiffness. Here, we overcome this constraint with an electrically insulating composite that exhibits an unprecedented combination of metal-like thermal conductivity, an elastic compliance similar to soft biological tissue (Young's modulus < 100 kPa), and the capability to undergo extreme deformations (>600% strain). By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ∼25× increase in thermal conductivity (4.7 ± 0.2 W⋅m -1 ⋅K -1 ) over the base polymer (0.20 ± 0.01 W⋅m -1 ·K -1 ) under stress-free conditions and a ∼50× increase (9.8 ± 0.8 W⋅m -1 ·K -1 ) when strained. This exceptional combination of thermal and mechanical properties is enabled by a unique thermal-mechanical coupling that exploits the deformability of the LM inclusions to create thermally conductive pathways in situ. Moreover, these materials offer possibilities for passive heat exchange in stretchable electronics and bioinspired robotics, which we demonstrate through the rapid heat dissipation of an elastomer-mounted extreme high-power LED lamp and a swimming soft robot.

Self-Consistent Atmosphere Models of the Most Extreme Hot Jupiters

NASA Astrophysics Data System (ADS)

Lothringer, Joshua; Barman, Travis

2018-01-01

We present a detailed look at self-consistent PHOENIX atmosphere models of the most highly irradiated hot Jupiters known to exist. These hot Jupiters typically have equilibrium temperatures approaching and sometimes exceeding 3000 K, orbiting A, F, and early-G type stars on orbits less than 0.03 AU (10x closer than Mercury is to the Sun). The most extreme example, KELT-9b, is the hottest known hot Jupiter with a measured dayside temperature of 4600 K. Many of the planets we model have recently attracted attention with high profile discoveries, including temperature inversions in WASP-33b and WASP-121, changing phase curve offsets possibly caused by magnetohydrodymanic effects in HAT-P-7b, and TiO in WASP-19b. Our modeling provides a look at the a priori expectations for these planets and helps us understand these recent discoveries. We show that, in the hottest cases, all molecules are dissociated down to relatively high pressures. These planets may have detectable temperature inversions, more akin to thermospheres than stratospheres in that an optical absorber like TiO or VO is not needed. Instead, the inversions are created by a lack of cooling in the IR combined with heating from atoms and ions at UV and blue optical wavelengths. We also reevaluate some of the assumptions that have been made in retrieval analyses of these planets.

Swept-frequency feedback interferometry using terahertz frequency QCLs: a method for imaging and materials analysis.

PubMed

Rakić, Aleksandar D; Taimre, Thomas; Bertling, Karl; Lim, Yah Leng; Dean, Paul; Indjin, Dragan; Ikonić, Zoran; Harrison, Paul; Valavanis, Alexander; Khanna, Suraj P; Lachab, Mohammad; Wilson, Stephen J; Linfield, Edmund H; Davies, A Giles

2013-09-23

The terahertz (THz) frequency quantum cascade laser (QCL) is a compact source of high-power radiation with a narrow intrinsic linewidth. As such, THz QCLs are extremely promising sources for applications including high-resolution spectroscopy, heterodyne detection, and coherent imaging. We exploit the remarkable phase-stability of THz QCLs to create a coherent swept-frequency delayed self-homodyning method for both imaging and materials analysis, using laser feedback interferometry. Using our scheme we obtain amplitude-like and phase-like images with minimal signal processing. We determine the physical relationship between the operating parameters of the laser under feedback and the complex refractive index of the target and demonstrate that this coherent detection method enables extraction of complex refractive indices with high accuracy. This establishes an ultimately compact and easy-to-implement THz imaging and materials analysis system, in which the local oscillator, mixer, and detector are all combined into a single laser.

Self-activated ultrahigh chemosensitivity of oxide thin film nanostructures for transparent sensors

PubMed Central

Moon, Hi Gyu; Shim, Young-Soek; Kim, Do Hong; Jeong, Hu Young; Jeong, Myoungho; Jung, Joo Young; Han, Seung Min; Kim, Jong Kyu; Kim, Jin-Sang; Park, Hyung-Ho; Lee, Jong-Heun; Tuller, Harry L.; Yoon, Seok-Jin; Jang, Ho Won

2012-01-01

One of the top design priorities for semiconductor chemical sensors is developing simple, low-cost, sensitive and reliable sensors to be built in handheld devices. However, the need to implement heating elements in sensor devices, and the resulting high power consumption, remains a major obstacle for the realization of miniaturized and integrated chemoresistive thin film sensors based on metal oxides. Here we demonstrate structurally simple but extremely efficient all oxide chemoresistive sensors with ~90% transmittance at visible wavelengths. Highly effective self-activation in anisotropically self-assembled nanocolumnar tungsten oxide thin films on glass substrate with indium-tin oxide electrodes enables ultrahigh response to nitrogen dioxide and volatile organic compounds with detection limits down to parts per trillion levels and power consumption less than 0.2 microwatts. Beyond the sensing performance, high transparency at visible wavelengths creates opportunities for their use in transparent electronic circuitry and optoelectronic devices with avenues for further functional convergence. PMID:22905319

[Principles of management of All-Russia Disaster Medicine Services].

PubMed

Sakhno, I I

2000-11-01

Experience of liquidation of earthquake consequences in Armenia (1988) has shown that it is extremely necessary to create the system of management in regions of natural disaster, large accident or catastrophe before arrival of main forces in order to provide reconnaissance, to receive the arriving units. It will help to make well-grounded decisions, to set tasks in time, to organize and conduct emergency-and-rescue works. The article contains general material concerning the structure of All-Russia service of disaster medicine (ARSDM), organization of management at all levels and interaction between the components of ARSDM and other subsystems of Russian Service of Extreme Situations. It is recommended how to organize management of ARSDM during liquidation of medical-and-sanitary consequences of large-scale extreme situations.

Effect of Annealing on the Passive Film Stability and Corrosion Resistance of New Families of Iron-Based Amorphous Metals

DTIC Science & Technology

2011-06-01

metallic glass easier to create and more stable once formed, thus improving the corrosion resistance. Adding titanium will enable the formation of...glass easier to create and more stable once formed, thus improving the corrosion resistance. Adding titanium will enable the formation of an extremely...research, it was hypothesized that additions of titanium could enable the formation of a protective titanium oxide film on the surface of the alloy

The evolution of extreme precipitations in high resolution scenarios over France

NASA Astrophysics Data System (ADS)

Colin, J.; Déqué, M.; Somot, S.

2009-09-01

Over the past years, improving the modelling of extreme events and their variability at climatic time scales has become one of the challenging issue raised in the regional climate research field. This study shows the results of a high resolution (12 km) scenario run over France with the limited area model (LAM) ALADIN-Climat, regarding the representation of extreme precipitations. The runs were conducted in the framework of the ANR-SCAMPEI national project on high resolution scenarios over French mountains. As a first step, we attempt to quantify one of the uncertainties implied by the use of LAM : the size of the area on which the model is run. In particular, we address the issue of whether a relatively small domain allows the model to create its small scale process. Indeed, high resolution scenarios cannot be run on large domains because of the computation time. Therefore one needs to answer this preliminary question before producing and analyzing such scenarios. To do so, we worked in the framework of a « big brother » experiment. We performed a 23-year long global simulation in present-day climate (1979-2001) with the ARPEGE-Climat GCM, at a resolution of approximately 50 km over Europe (stretched grid). This first simulation, named ARP50, constitutes the « big brother » reference of our experiment. It has been validated in comparison with the CRU climatology. Then we filtered the short waves (up to 200 km) from ARP50 in order to obtain the equivalent of coarse resolution lateral boundary conditions (LBC). We have carried out three ALADIN-Climat simulations at a 50 km resolution with these LBC, using different configurations of the model : * FRA50, run over a small domain (2000 x 2000 km, centered over France), * EUR50, run over a larger domain (5000 x 5000 km, centered over France as well), * EUR50-SN, run over the large domain (using spectral nudging). Considering the facts that ARPEGE-Climat and ALADIN-Climat models share the same physics and dynamics and that both regional and global simulations were run at the same resolution, ARP50 can be regarded as a reference with which FRA50, EUR50 and EUR50-SN should each be compared. After an analysis of the differences between the regional simulations and ARP50 in annual and seasonal mean, we focus on the representation of rainfall extremes comparing two dimensional fields of various index inspired from STARDEX and quantile-quantile plots. The results show a good agreement with the ARP50 reference for all three regional simulations and little differences are found between them. This result indicates that the use of small domains is not significantly detrimental to the modelling of extreme precipitation events. It also shows that the spectral nudging technique has no detrimental effect on the extreme precipitation. Therefore, high resolution scenarios performed on a relatively small domain such as the ones run for SCAMPEI, can be regarded as good tools to explore their possible evolution in the future climate. Preliminary results on the response of precipitation extremes over South-East France are given.

The association between consecutive days' heat wave and cardiovascular disease mortality in Beijing, China.

PubMed

Yin, Qian; Wang, Jinfeng

2017-02-23

Although many studies have examined the effects of heat waves on the excess mortality risk (ER) posed by cardiovascular disease (CVD), scant attention has been paid to the effects of various combinations of differing heat wave temperatures and durations. We investigated such effects in Beijing, a city of over 20 million residents. A generalized additive model (GAM) was used to analyze the ER of consecutive days' exposure to extreme high temperatures. A key finding was that when extremely high temperatures occur continuously, at varying temperature thresholds and durations, the adverse effects on CVD mortality vary significantly. The longer the heat wave lasts, the greater the mortality risk is. When the daily maximum temperature exceeded 35 °C from the fourth day onward, the ER attributed to consecutive days' high temperature exposure saw an increase to about 10% (p < 0.05), and at the fifth day, the ER even reached 51%. For the thresholds of 32 °C, 33 °C, and 34 °C, from the fifth day onward, the ER also rose sharply (16, 29, and 31%, respectively; p < 0.05). In addition, extreme high temperatures appeared to contribute to a higher proportion of CVD deaths among elderly persons, females and outdoor workers. When the daily maximum temperature was higher than 33 °C from the tenth consecutive day onward, the ER of CVD death among these groups was 94, 104 and 149%, respectively (p < 0.05), which is considerably higher than the ER for the overall population (87%; p < 0.05). The results of this study may assist governments in setting standards for heat waves, creating more accurate heat alerts, and taking measures to prevent or reduce temperature-related deaths, especially against the backdrop of global warming.

The Climatology of Extreme Surge-Producing Extratropical Cyclones in Observations and Models

NASA Astrophysics Data System (ADS)

Catalano, A. J.; Broccoli, A. J.; Kapnick, S. B.

2016-12-01

Extreme coastal storms devastate heavily populated areas around the world by producing powerful winds that can create a large storm surge. Both tropical and extratropical cyclones (ETCs) occur over the northwestern Atlantic Ocean, and the risks associated with ETCs can be just as severe as those associated with tropical storms (e.g. high winds, storm surge). At The Battery in New York City, 17 of the 20 largest storm surge events were a consequence of extratropical cyclones (ETCs), which are more prevalent than tropical cyclones in the northeast region of the United States. Therefore, we analyze the climatology of ETCs that are capable of producing a large storm surge along the northeastern coast of the United States. For a historical analysis, water level data was collected from National Oceanic and Atmospheric Administration (NOAA) tide gauges at three separate locations (Sewell's Pt., VA, The Battery, NY, and Boston, MA). We perform a k-means cluster analysis of sea level pressure from the ECMWF 20th Century Reanalysis dataset (ERA-20c) to explore the natural sets of observed storms with similar characteristics. We then composite cluster results with features of atmospheric circulation to observe the influence of interannual and multidecadal variability such as the North Atlantic Oscillation. Since observational records contain a small number of well-documented ETCs, the capability of a high-resolution coupled climate model to realistically simulate such extreme coastal storms will also be assessed. Global climate models provide a means of simulating a much larger sample of extreme events, allowing for better resolution of the tail of the distribution. We employ a tracking algorithm to identify ETCs in a multi-century simulation under present-day conditions. Quantitative comparisons of cyclolysis, cyclogenesis, and cyclone densities of simulated ETCs and storms from recent history (using reanalysis products) are conducted.

UNIVERSE IN A BLACK HOLE IN EINSTEIN–CARTAN GRAVITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Popławski, Nikodem, E-mail: NPoplawski@newhaven.edu

The conservation law for the angular momentum in curved spacetime, consistent with relativistic quantum mechanics, requires that the antisymmetric part of the affine connection (torsion tensor) is a variable in the principle of least action. The coupling between the spin of elementary particles and torsion in the Einstein–Cartan theory of gravity generates gravitational repulsion at extremely high densities in fermionic matter, approximated as a spin fluid, and thus avoids the formation of singularities in black holes. The collapsing matter in a black hole should therefore bounce at a finite density and then expand into a new region of space onmore » the other side of the event horizon, which may be regarded as a nonsingular, closed universe. We show that quantum particle production caused by an extremely high curvature near a bounce can create enormous amounts of matter, produce entropy, and generate a finite period of exponential expansion (inflation) of this universe. This scenario can thus explain inflation without a scalar field and reheating. We show that, depending on the particle production rate, such a universe may undergo several nonsingular bounces until it has enough matter to reach a size at which the cosmological constant starts cosmic acceleration. The last bounce can be regarded as the big bang of this universe.« less

Universe in a Black Hole in Einstein-Cartan Gravity

NASA Astrophysics Data System (ADS)

Popławski, Nikodem

2016-12-01

The conservation law for the angular momentum in curved spacetime, consistent with relativistic quantum mechanics, requires that the antisymmetric part of the affine connection (torsion tensor) is a variable in the principle of least action. The coupling between the spin of elementary particles and torsion in the Einstein-Cartan theory of gravity generates gravitational repulsion at extremely high densities in fermionic matter, approximated as a spin fluid, and thus avoids the formation of singularities in black holes. The collapsing matter in a black hole should therefore bounce at a finite density and then expand into a new region of space on the other side of the event horizon, which may be regarded as a nonsingular, closed universe. We show that quantum particle production caused by an extremely high curvature near a bounce can create enormous amounts of matter, produce entropy, and generate a finite period of exponential expansion (inflation) of this universe. This scenario can thus explain inflation without a scalar field and reheating. We show that, depending on the particle production rate, such a universe may undergo several nonsingular bounces until it has enough matter to reach a size at which the cosmological constant starts cosmic acceleration. The last bounce can be regarded as the big bang of this universe.

Flexible Dielectric Nanocomposites with Ultrawide Zero-Temperature Coefficient Windows for Electrical Energy Storage and Conversion under Extreme Conditions.

PubMed

Shehzad, Khurram; Xu, Yang; Gao, Chao; Li, Hanying; Dang, Zhi-Min; Hasan, Tawfique; Luo, Jack; Duan, Xiangfeng

2017-03-01

Polymer dielectrics offer key advantages over their ceramic counterparts such as flexibility, scalability, low cost, and high breakdown voltages. However, a major drawback that limits more widespread application of polymer dielectrics is their temperature-dependent dielectric properties. Achieving dielectric constants with low/zero-temperature coefficient (L/0TC) over a broad temperature range is essential for applications in diverse technologies. Here, we report a hybrid filler strategy to produce polymer composites with an ultrawide L/0TC window of dielectric constant, as well as a significantly enhanced dielectric value, maximum energy storage density, thermal conductivity, and stability. By creating a series of percolative polymer composites, we demonstrated hybrid carbon filler based composites can exhibit a zero-temperature coefficient window of 200 °C (from -50 to 150 °C), the widest 0TC window for all polymer composite dielectrics reported to date. We further show the electric and dielectric temperature coefficient of the composites is highly stable against stretching and bending, even under AC electric field with frequency up to 1 MHz. We envision that our method will push the functional limits of polymer dielectrics for flexible electronics in extreme conditions such as in hybrid vehicles, aerospace, power electronics, and oil/gas exploration.

Desertification of the peritoneum by thin-film evaporation during laparoscopy.

PubMed

Ott, Douglas E

2003-01-01

To assess the effects of gas flow during insufflation on peritoneal fluid and peritoneal tissue regarding transient thermal behavior and thin-film evaporation. The effects of laparoscopic gas on peritoneal cell desiccation and peritoneal fluid thin-film evaporation were analyzed. Measurment of tissue and peritoneal fluid and analysis of gas flow dynamics during laparoscopy. High-velocity gas interface conditions during laparoscopic gas insufflation result in peritoneal surface temperature and decreases up to 20 degrees C/second due to rapid thin-film evaporation of the peritoneal fluid. Evaporation of the thin film of peritoneal fluid extends quickly to the peritoneal cell membrane, causing peritoneal cell desiccation, internal cytoplasmic stress, and disruption of the cell membrane, resulting in loss of peritoneal surface continuity and integrity. Changing the gas conditions to 35 degrees C and 95% humidity maintains normal peritoneal fluid thin-film characteristics, cellular integrity, and prevents evaporative losses. Cold, dry gas and the characteristics of the laparoscopic gas delivery apparatus cause local peritoneal damaging alterations by high-velocity gas flow with extremely dry gas, creating extreme arid surface conditions, rapid evaporative and hydrological changes, tissue desiccation, and peritoneal fluid alterations that contribute to the process of desertification and thin-film evaporation. Peritoneal desertification is preventable by preconditioning the gas to 35 degrees C and 95% humidity.

KSC-2009-3214

NASA Image and Video Library

2008-10-09

CAPE CANAVERAL, Fla. – This is the radome beneath which is the NASA Debris Radar. It is located at a remote site on North Merritt Island in Florida. One of the largest of its kind in the world, the C-band radar provided critical support to pinpoint debris during the launch of space shuttle Atlantis on the STS-125 mission. The need for this radar was identified after the Columbia tragedy. It worked together with smaller X-band radars placed on the solid rocket booster ship Liberty Star and the U.S. Army landing craft utility ship Brandy Station. Together they provided extremely high resolution images of any debris that created by Atlantis during launch. Photo credit: NASA/Troy Cryder

KSC-2009-3209

NASA Image and Video Library

2008-10-09

CAPE CANAVERAL, Fla. – This is the radome beneath which is the NASA Debris Radar. It is located at a remote site on North Merritt Island in Florida. One of the largest of its kind in the world, the C-band radar provided critical support to pinpoint debris during the launch of space shuttle Atlantis on the STS-125 mission. The need for this radar was identified after the Columbia tragedy. It worked together with smaller X-band radars placed on the solid rocket booster ship Liberty Star and the U.S. Army landing craft utility ship Brandy Station. Together they provided extremely high resolution images of any debris that created by Atlantis during launch. Photo credit: NASA/Troy Cryder

KSC-2009-3215

NASA Image and Video Library

2008-10-09

CAPE CANAVERAL, Fla. – This is the radome beneath which is the NASA Debris Radar. It is located at a remote site on North Merritt Island in Florida. One of the largest of its kind in the world, the C-band radar provided critical support to pinpoint debris during the launch of space shuttle Atlantis on the STS-125 mission. The need for this radar was identified after the Columbia tragedy. It worked together with smaller X-band radars placed on the solid rocket booster ship Liberty Star and the U.S. Army landing craft utility ship Brandy Station. Together they provided extremely high resolution images of any debris that created by Atlantis during launch. Photo credit: NASA/Troy Cryder

KSC-2009-3210

NASA Image and Video Library

2008-10-09

CAPE CANAVERAL, Fla. – This is the radome beneath which is the NASA Debris Radar. It is located at a remote site on North Merritt Island in Florida. One of the largest of its kind in the world, the C-band radar provided critical support to pinpoint debris during the launch of space shuttle Atlantis on the STS-125 mission. The need for this radar was identified after the Columbia tragedy. It worked together with smaller X-band radars placed on the solid rocket booster ship Liberty Star and the U.S. Army landing craft utility ship Brandy Station. Together they provided extremely high resolution images of any debris that created by Atlantis during launch. Photo credit: NASA/Troy Cryder

IMAX camera (12-IML-1)

NASA Technical Reports Server (NTRS)

1992-01-01

The IMAX camera system is used to record on-orbit activities of interest to the public. Because of the extremely high resolution of the IMAX camera, projector, and audio systems, the audience is afforded a motion picture experience unlike any other. IMAX and OMNIMAX motion picture systems were designed to create motion picture images of superior quality and audience impact. The IMAX camera is a 65 mm, single lens, reflex viewing design with a 15 perforation per frame horizontal pull across. The frame size is 2.06 x 2.77 inches. Film travels through the camera at a rate of 336 feet per minute when the camera is running at the standard 24 frames/sec.

NASA's Hybrid Reality Lab: One Giant Leap for Full Dive

NASA Technical Reports Server (NTRS)

Delgado, Francisco J.; Noyes, Matthew

2017-01-01

This presentation demonstrates how NASA is using consumer VR headsets, game engine technology and NVIDIA's GPUs to create highly immersive future training systems augmented with extremely realistic haptic feedback, sound, additional sensory information, and how these can be used to improve the engineering workflow. Include in this presentation is an environment simulation of the ISS, where users can interact with virtual objects, handrails, and tracked physical objects while inside VR, integration of consumer VR headsets with the Active Response Gravity Offload System, and a space habitat architectural evaluation tool. Attendees will learn how the best elements of real and virtual worlds can be combined into a hybrid reality environment with tangible engineering and scientific applications.

Comparison of upper extremity glenohumeral joint forces in children with cerebral palsy using anterior and posterior walkers - biomed 2009.

PubMed

Strifling, Kelly M B; Konop, Katherine A; Wang, Mei; Harris, Gerald F

2009-01-01

Walkers are prescribed with the notion that one type of walker will be better for a child than another. One underlying justification for this practice is the theory that one walker may produce less stress on the upper extremities as the patient uses the walker. Nevertheless, upper extremity joint loading is not typically analyzed during walker assisted gait in children with spastic diplegic cerebral palsy. It has been difficult to evaluate the theory of walker prescription based on upper extremity stresses because loading on the upper extremities however has not been quantified until recently. In this study, weight bearing on the glenohumeral joints was analyzed in five children with spastic diplegic cerebral palsy using both anterior and posterior walkers fitted with 6-axis handle transducers. Though walkers' effects on the upper extremities proved to be similar between walker types, the differences between the walkers may have some clinical significance in the long run. In general, posterior walker use created larger glenohumeral joint forces. Though these differences are not statistically significant, over time and with repetitive loading they may be clinically significant.

General approach to boat simulation in virtual reality systems

NASA Astrophysics Data System (ADS)

Aranov, Vladislav Y.; Belyaev, Sergey Y.

2002-02-01

The paper is dedicated to real time simulation of sport boats, particularly a kayak and high-speed skimming boat, for training goals. This training is issue of the day, since kayaking and riding a high-speed skimming boat are both extreme sports. Participating in such types of competitions puts sportsmen into danger, particularly due to rapids, waterfalls, different water streams, and other obstacles. In order to make the simulation realistic, it is necessary to calculate data for at least 30 frames per second. These calculations may take not more than 5% CPU time, because very time-consuming 3D rendering process takes the rest - 95% CPU time. This paper describes an approach for creating minimal boat simulator models that satisfy the mentioned requirements. Besides, this approach can be used for other watercraft models of this kind.

Subsonic and Supersonic shear flows in laser driven high-energy-density plasmas

NASA Astrophysics Data System (ADS)

Harding, E. C.; Drake, R. P.; Gillespie, R. S.; Grosskopf, M. J.; Kuranz, C. C.; Visco, A.; Ditmar, J. R.; Aglitskiy, Y.; Weaver, J. L.; Velikovich, A. L.; Hurricane, O. A.; Hansen, J. F.; Remington, B. A.; Robey, H. F.; Bono, M. J.; Plewa, T.

2009-05-01

Shear flows arise in many high-energy-density (HED) and astrophysical systems, yet few laboratory experiments have been carried out to study their evolution in these extreme environments. Fundamentally, shear flows can initiate mixing via the Kelvin-Helmholtz (KH) instability and may eventually drive a transition to turbulence. We present two dedicated shear flow experiments that created subsonic and supersonic shear layers in HED plasmas. In the subsonic case the Omega laser was used to drive a shock wave along a rippled plastic interface, which subsequently rolled-upped into large KH vortices. In the supersonic shear experiment the Nike laser was used to drive Al plasma across a low-density foam surface also seeded with a ripple. Unlike the subsonic case, detached shocks developed around the ripples in response to the supersonic Al flow.

Rationale and design of the ARCUS: Effects of trAnsRadial perCUtaneouS coronary intervention on upper extremity function.

PubMed

Zwaan, Eva M; IJsselmuiden, Alexander J J; van Rosmalen, Joost; van Geuns, Robert-Jan M; Amoroso, Giovanni; Moerman, Esther; Ritt, Marco J P F; Schreuders, Ton A R; Kofflard, Marcel J M; Holtzer, Carlo A J

2016-12-01

The aim of this study is to provide a complete insight in the access-site morbidity and upper extremity function after Transradial Percutaneous Coronary Intervention (TR-PCI). In percutaneous coronary intervention the Transradial Approach (TRA) is gaining popularity as a default technique. It is a very promising technique with respect to post-procedure complications, but the exact effects of TRA on upper extremity function are unknown. The effects of trAnsRadial perCUtaneouS coronary intervention on upper extremity function (ARCUS) trial is a multicenter prospective cohort study that will be conducted in all patients admitted for TR-PCI. Clinical outcomes will be monitored during a follow-up of 6 months, with its primary endpoint at two weeks of follow-up. To investigate the complete upper extremity function, a combination of physical examinations and validated questionnaires will be used to provide information on anatomical integrity, strength, range of motion (ROM), coordination, sensibility, pain, and functioning in everyday life. Procedural and material specifications will be registered in order to include all possible aspects influencing upper extremity function. Results from this study will elucidate the effect of TR-PCI on upper extremity function. This creates the opportunity to further optimize TR-PCI, to make improvements in functional outcome and to prevent morbidity regarding full upper extremity function. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Role 2 military hospitals: results of a new trauma care concept on 170 casualties.

PubMed

Ünlü, A; Cetinkaya, R A; Ege, T; Ozmen, P; Hurmeric, V; Ozer, M T; Petrone, P

2015-04-01

In recent military conflicts, military surgeons encounter more high-energy injuries associated with explosives. Advances in the field care and shorter evacuation time increased survival. However, casualties still incur severe injuries especially to the extremities. We present wound patterns, anatomical distribution and severity of injuries in a Role 2 hospital. Two years data have been retrospectively reviewed. Only explosives and firearms injuries were included in the study. Patient profile, admission details, mechanism of injury, AIS anatomical locations, ISS, surgical and medical treatments have been analyzed. Data revealed 170 male casualties. IEDs and GSW accounted for 133 (78%) and 37 (22%) casualties, respectively. An average of 1.8 IED and 1.2 GSW anatomical locations were exposed to injuries. Regardless of the mechanism, injuries were most commonly located in the extremities. IEDs caused significantly higher soft tissue injuries. Explosives do not necessarily cause more severe injuries than firearms. However, fragments create multiple, complicated soft tissue injuries which constitute more than half of the injuries. Timely wound debridement and excision of contaminated tissue are crucial to manage extremity soft tissue injuries. Casualty care should be assessed within the context of the capabilities present at a hospital and the cause, type and severity of the wounds. The NATO description of Role 2 care only requires an integrated surgical team for damage control surgery with limited diagnostic and infrastructural capabilities.

Predicting the possibility of not yet observed situations as higher goal of space environment standards.

NASA Astrophysics Data System (ADS)

Nymmik, Rikho

Space environment models are intended for fairly describing the quantitative behavior of nature space environment. Usually, they are constructed on the basis of some experimental data set generalization, which is characteristic of the conditions that were taking place during measurement period. It is often to see that such models state and postulate realities of the past. The typical example of this point of view is the situation around extremely SEP events. During dozens of years models of such events have been based on the largest occurrences observed, which features were measured by some instruments with the reliability that was not always analyzed. It is obvious, that this way does not agree with reality, because any new extreme event conflicts with it. From this follow that space environment models can not be created by using numerical observed data only, when such data are changing in time, or have the probability nature. The model's goal is not only describing the average environment characteristics, but the predicting of extreme ones too. Such a prediction can only be result of analyzing the causes that stimulate environment change and taking them into account in model parameters. In this report we present the analysis of radiation environment formed by solar-generated high energy particles. A progresses and failures of SEP event modeling attempts are also shown and analyzed.

A global assessment of NASA AIRS v6 and EUMETSAT IASI v6 precipitable water vapor using ground-based GPS SuomiNet stations

NASA Astrophysics Data System (ADS)

Roman, Jacola; Knuteson, Robert; August, Thomas; Hultberg, Tim; Ackerman, Steve; Revercomb, Hank

2016-08-01

Satellite remote sensing of precipitable water vapor (PWV) is essential for monitoring moisture in real time for weather applications, as well as tracking the long-term changes in PWV for climate change trend detection. This study assesses the accuracies of the current satellite observing system, specifically the National Aeronautics and Space Administration (NASA) Atmospheric Infrared Sounder (AIRS) v6 PWV product and the European Organization for the Exploitation of Meteorological Satellite Studies (EUMETSAT) Infrared Atmospheric Sounding Interferometer (IASI) v6 PWV product, using ground-based SuomiNet Global Positioning System (GPS) network as truth. Elevation-corrected collocated matchups to each SuomiNet GPS station in North America and around the world were created, and results were broken down by station, ARM region, climate zone, and latitude zone. The greatest difference, exceeding 5%, between IASI and AIRS retrievals occurred in the tropics. Generally, IASI and AIRS fall within a 5% error in the PWV range of 20-40 mm (a mean bias less than 2 mm), with a wet bias for extremely low PWV values (less than 5 mm) and a dry bias for extremely high PWV values (greater than 50 mm). The operational IR satellite products are able to capture the mean PWV but degrade in the extreme dry and wet regimes.

Perceptions of Emergency Medicine Residency and Hand Surgery Fellowship Program Directors in the Appropriate Disposition of Upper Extremity Emergencies.

PubMed

Drolet, Brian C; Lifchez, Scott D; Jacoby, Sidney M; Varone, Andrew; Regan, Linda A; Baren, Jill M; Akelman, Edward; Osterman, A Lee; Levin, L Scott

2015-12-01

To survey emergency medicine (EM) residency and hand surgery fellowship program directors (PDs) to identify consensus in their perceptions of appropriate emergency care of upper extremity emergencies. We created a framework to group common upper extremity emergency diagnoses and surveyed PDs to evaluate the training background--EM, general orthopedic or plastic surgery, or hand fellowship--most appropriate to provide acute, point-of-care management for each of these diagnostic groupings. Responses were pooled and consensus was established with greater than 75% agreement between groups. We received 79 responses from hand fellowship PDs (90% response rate) and 151 responses from EM PDs (49% response rate). We identified consensus for the training background that PDs in both specialties felt was appropriate to care for 17 of 21 diagnostic groupings in the framework. There was a high level of consensus between EM and hand surgery PDs regarding diagnoses that acutely require training in hand surgery versus those that can be managed by an EM physician. Our diagnostic framework may help reduce unnecessary hand surgery consultation and may help to identify patients who do not require more specialized acute care and thus decrease unnecessary transfers. Economic and Decision Analyses IV. Copyright © 2015 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Performance of multimirror quartzline lamps in a high-pressure, underwater environment

NASA Technical Reports Server (NTRS)

Slater, Howard A.

1988-01-01

Multimirror Quartzline Lamps are extremely versatile and effective for nonconventional imaging requirements such as high-speed photo and video instrumentation and high-magnification imaging. The lamps' versatility though, is not limited to conventional environments. Many research experiments and projects require a high pressure environment. Continuous photographic data acquisition in a high-pressure vessel requires wall penetrations and creates design problems as well as potential failure sites. Underwater photography adds the extra consideration of a liquid. This report expands upon the basic research presented in, Performance of Multimirror Quartzline Lamps in High-Pressure Environments, (NASA-TM-83793, Ernie Walker and Howard Slater, 1984). The report provides information to professional industrial, scientific, and technical photographers as well as research personnel on the survivability of lighting a multimirror quartzline lamp in a nonconventional high-pressure underwater environment. Test results of lighted ELH 300 W multimirror quartzline lamps under high-pressure conditions are documented and general information on the lamps' intensity (footcandle output), cone of light coverage, approximate color temperature is provided. Continuous lighting considerations in liquids are also discussed.

Reconstruction of Solar Extreme Ultraviolet Flux 1740 - 2015

NASA Astrophysics Data System (ADS)

Svalgaard, Leif

2016-11-01

Solar extreme ultraviolet (EUV) radiation creates the conducting E-layer of the ionosphere, mainly by photo-ionization of molecular oxygen. Solar heating of the ionosphere creates thermal winds, which by dynamo action induce an electric field driving an electric current having a magnetic effect observable on the ground, as was discovered by G. Graham in 1722. The current rises and falls with the Sun, and thus causes a readily observable diurnal variation of the geomagnetic field, allowing us to deduce the conductivity and thus the EUV flux as far back as reliable magnetic data reach. High-quality data go back to the "Magnetic Crusade" of the 1830s and less reliable, but still usable, data are available for portions of the 100 years before that. J.R. Wolf and, independently, J.-A. Gautier discovered the dependence of the diurnal variation on solar activity, and today we understand and can invert that relationship to construct a reliable record of the EUV flux from the geomagnetic record. We compare that to the F_{10.7} flux and the sunspot number, and we find that the reconstructed EUV flux reproduces the F_{10.7} flux with great accuracy. On the other hand, it appears that the Relative Sunspot Number as currently defined is beginning to no longer be a faithful representation of solar magnetic activity, at least as measured by the EUV and related indices. The reconstruction suggests that the EUV flux reaches the same low (but non-zero) value at every sunspot minimum (possibly including Grand Minima), representing an invariant "solar magnetic ground state".

SSME lifetime prediction and verification, integrating environments, structures, materials: The challenge

NASA Technical Reports Server (NTRS)

Ryan, R. S.; Salter, L. D.; Young, G. M., III; Munafo, P. M.

1985-01-01

The planned missions for the space shuttle dictated a unique and technology-extending rocket engine. The high specific impulse requirements in conjunction with a 55-mission lifetime, plus volume and weight constraints, produced unique structural design, manufacturing, and verification requirements. Operations from Earth to orbit produce severe dynamic environments, which couple with the extreme pressure and thermal environments associated with the high performance, creating large low cycle loads and high alternating stresses above endurance limit which result in high sensitivity to alternating stresses. Combining all of these effects resulted in the requirements for exotic materials, which are more susceptible to manufacturing problems, and the use of an all-welded structure. The challenge of integrating environments, dynamics, structures, and materials into a verified SSME structure is discussed. The verification program and developmental flight results are included. The first six shuttle flights had engine performance as predicted with no failures. The engine system has met the basic design challenges.

Discovering highly obscured AGN with the Swift-BAT 100-month survey

NASA Astrophysics Data System (ADS)

Marchesi, Stefano; Ajello, Marco; Comastri, Andrea; Cusumano, Giancarlo; La Parola, Valentina; Segreto, Alberto

2017-01-01

In this talk, I present a new technique to find highly obscured AGN using the 100-month Swift-BAT survey. I will show the results of the combined Chandra and BAT spectral analysis in the 0.3-150 keV band of seven Seyfert 2 galaxies selected from the 100-month BAT catalog. We selected nearby (z<0.03) sources lacking of a ROSAT counterpart and never previously observed in the 0.3-10 keV energy range. All the objects are significantly obscured, having NH>1E23 cm-2 at a >99% confidence level, and one to three sources are candidate Compton thick Active Galactic Nuclei (CT-AGN), i.e., have NH>1E24 cm-2.Since the selection criteria we adopted have been extremely effective in detecting highly obscured AGN, further observations of these and other Seyfert 2 galaxies selected from the BAT 100-month catalog will allow us to create a statistically significant sample of highly obscured AGN, therefore better understanding the physics of the obscuration processes.

Preferentially Oriented Ag Nanocrystals with Extremely High Activity and Faradaic Efficiency for CO2 Electrochemical Reduction to CO.

PubMed

Peng, Xiong; Karakalos, Stavros G; Mustain, William E

2018-01-17

Selective electrochemical reduction of CO 2 is one of the most important processes to study because of its promise to convert this greenhouse gas to value-added chemicals at low cost. In this work, a simple anodization treatment was devised that first oxidizes Ag to Ag 2 CO 3 , then uses rapid electrochemical reduction to create preferentially oriented nanoparticles (PONs) of metallic Ag (PON-Ag) with high surface area as well as high activity and very high selectivity for the reduction of CO 2 to CO. The PON-Ag catalyst was dominated by (110) and (100) orientation, which allowed PON-Ag to achieve a CO Faradaic efficiency of 96.7% at an operating potential of -0.69 V vs RHE. This performance is not only significantly higher than that of polycrystalline Ag (60% at -0.87 V vs RHE) but also represents one of the best combinations of activity and selectivity achieved to date - all with a very simple, scalable approach to electrode fabrication.

Autofluorescence-Free Live-Cell Imaging Using Terbium Nanoparticles.

PubMed

Cardoso Dos Santos, M; Goetz, J; Bartenlian, H; Wong, K-L; Charbonnière, L J; Hildebrandt, N

2018-04-18

Fluorescent nanoparticles (NPs) have become irreplaceable tools for advanced cellular and subcellular imaging. While very bright NPs require excitation with UV or visible light, which can create strong autofluorescence of biological components, NIR-excitable NPs without autofluorescence issues exhibit much lower brightness. Here, we show the application of a new type of surface-photosensitized terbium NPs (Tb-NPs) for autofluorescence-free intracellular imaging in live HeLa cells. The combination of exceptionally high brightness, high photostability, and long photoluminecence (PL) lifetimes for highly efficient suppression of the short-lived autofluorescence allowed for time-gated PL imaging of intracellular vesicles over 72 h without toxicity and at extremely low Tb-NP concentrations down to 12 pM. Detection of highly resolved long-lifetime (ms) PL decay curves from small (∼10 μm 2 ) areas within single cells within a few seconds emphasized the unprecedented photophysical properties of Tb-NPs for live-cell imaging that extend well beyond currently available nanometric imaging agents.

Integrated Power Adapter: Isolated Converter with Integrated Passives and Low Material Stress

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-09-01

ADEPT Project: CPES at Virginia Tech is developing an extremely efficient power converter that could be used in power adapters for small, lightweight laptops and other types of mobile electronic devices. Power adapters convert electrical energy into useable power for an electronic device, and they currently waste a lot of energy when they are plugged into an outlet to power up. CPES at Virginia Tech is integrating high-density capacitors, new magnetic materials, high-frequency integrated circuits, and a constant-flux transformer to create its efficient power converter. The high-density capacitors enable the power adapter to store more energy. The new magnetic materialsmore » also increase energy storage, and they can be precisely dispensed using a low-cost ink-jet printer which keeps costs down. The high-frequency integrated circuits can handle more power, and they can handle it more efficiently. And, the constant-flux transformer processes a consistent flow of electrical current, which makes the converter more efficient.« less

Statistical lamb wave localization based on extreme value theory

NASA Astrophysics Data System (ADS)

Harley, Joel B.

2018-04-01

Guided wave localization methods based on delay-and-sum imaging, matched field processing, and other techniques have been designed and researched to create images that locate and describe structural damage. The maximum value of these images typically represent an estimated damage location. Yet, it is often unclear if this maximum value, or any other value in the image, is a statistically significant indicator of damage. Furthermore, there are currently few, if any, approaches to assess the statistical significance of guided wave localization images. As a result, we present statistical delay-and-sum and statistical matched field processing localization methods to create statistically significant images of damage. Our framework uses constant rate of false alarm statistics and extreme value theory to detect damage with little prior information. We demonstrate our methods with in situ guided wave data from an aluminum plate to detect two 0.75 cm diameter holes. Our results show an expected improvement in statistical significance as the number of sensors increase. With seventeen sensors, both methods successfully detect damage with statistical significance.

Self-proton/ion radiography of laser-produced proton/ion beam from thin foil targets

NASA Astrophysics Data System (ADS)

Paudel, Y.; Renard-Le Galloudec, N.; Nicolai, Ph.; d'Humieres, E.; Ya. Faenov, A.; Kantsyrev, V. L.; Safronova, A. S.; Shrestha, I.; Osborne, G. C.; Shlyaptseva, V. V.; Sentoku, Y.

2012-12-01

Protons and multicharged ions generated from high-intensity laser interactions with thin foil targets have been studied with a 100 TW laser system. Protons/ions with energies up to 10 MeV are accelerated either from the front or the rear surface of the target material. We have observed for the first time that the protons/ions accelerated from the front surface of the target, in a direction opposite to the laser propagation direction, are turned around and pulled back to the rear surface, in the laser propagation direction. This proton/ion beam is able to create a self-radiograph of the target and glass stalk holding the target itself recorded through the radiochromic film stack. This unique result indicates strong long-living (ns time scale) magnetic fields present in the laser-produced plasma, which are extremely important in energy transport during the intense laser irradiation. The magnetic field from laser main pulse expands rapidly in the preformed plasma to rotate the laser produced protons. Radiation hydrodynamic simulations and ray tracing found that the magnetic field created by the amplified spontaneous emission prepulse is not sufficient to explain the particle trajectories, but the additional field created by the main pulse interaction estimated from particle-in-cell simulation is able to change the particle trajectories.

Scalable Analysis Methods and In Situ Infrastructure for Extreme Scale Knowledge Discovery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duque, Earl P.N.; Whitlock, Brad J.

High performance computers have for many years been on a trajectory that gives them extraordinary compute power with the addition of more and more compute cores. At the same time, other system parameters such as the amount of memory per core and bandwidth to storage have remained constant or have barely increased. This creates an imbalance in the computer, giving it the ability to compute a lot of data that it cannot reasonably save out due to time and storage constraints. While technologies have been invented to mitigate this problem (burst buffers, etc.), software has been adapting to employ inmore » situ libraries which perform data analysis and visualization on simulation data while it is still resident in memory. This avoids the need to ever have to pay the costs of writing many terabytes of data files. Instead, in situ enables the creation of more concentrated data products such as statistics, plots, and data extracts, which are all far smaller than the full-sized volume data. With the increasing popularity of in situ, multiple in situ infrastructures have been created, each with its own mechanism for integrating with a simulation. To make it easier to instrument a simulation with multiple in situ infrastructures and include custom analysis algorithms, this project created the SENSEI framework.« less

One-shot Synesthesia.

PubMed

Kirschner, Alexandra; Nikolić, Danko

2017-01-01

Synesthesia is commonly thought to be a phenomenon of fixed associations between an outside inducer and a vivid concurrent experience. Hence, it has been proposed that synesthesia occurs due to additional connections in the brain with which synesthetes are born. Here we show that synesthesia can be a much richer and more flexible phenomenon with a capability to creatively construct novel synesthetic experiences as events unfold in people's lives. We describe here cases of synesthetes who occasionally generate novel synesthetic experience, called one-shot synesthesias. These synesthetic experiences seem to share all the properties with the classical synesthetic associations except that they occur extremely rarely, people recalling only a few events over the lifetime. It appears that these one-shots are not created at random but are instead responses to specific life events. We contrast the properties of those rare synesthetic events with other, more commonly known forms of synesthesia that also create novel synesthetic experiences, but at a high rate-sometimes creating novel experiences every few seconds. We argue that one-shot synesthesias indicate that synesthetic associations are by their nature not prewired at birth but are dynamically constructed through mental operations and according to the needs of a synesthetic mind. Our conclusions have implications for understanding the biological underpinnings of synesthesia and the role the phenomenon plays in the lives of people endowed with synesthetic capacities.

Snow Depth from Lidar: Challenges and New Technology for Measurements in Extreme Terrain

NASA Astrophysics Data System (ADS)

Berisford, D. F.; Kadatskiy, V.; Boardman, J. W.; Bormann, K.; Deems, J. S.; Goodale, C. E.; Mattmann, C. A.; Ramirez, P.; Richardson, M.; Painter, T. H.

2014-12-01

The Airborne Snow Observatory (ASO) uses an airborne LiDAR system to measure basin-wide snow depth with cm-scale accuracy at ~1m spatial resolution. This is accomplished by creating a Digital Elevation Model (DEM) over snow-free terrain in the summer, then repeating the flights again when the terrain is snow-covered and subtracting the elevations. Snow Water Equivalent (SWE) is then calculated by incorporating modeled snow density estimates, and when combined with coincident spectrometer albedo measurements, informs distributed hydrologic modeling and runoff prediction. This method provides SWE estimates of unprecedented accuracy and extent compared to traditional snow surveys and towers, and 24hr latency data products through the ASO processing pipeline using Apache Tika and OODT software. The timely ASO outputs support operational decision making by water/dam operators for optimal water management. The water-resource snowpack in the western US lies in remote mountainous terrain, spanning large areas containing steep faces at all aspects, often amongst tree canopy. This extreme terrain presents unusual challenges for LiDAR, and requires high altitude flights to achieve wide area coverage, high point density to capture small terrain features, and the ability to capture all slope aspects without shadowing. These challenges were met by the new state-of-the-art Riegl LMS-Q1560 LiDAR system, which incorporates two independent laser channels and a single rotating mirror. Both lasers and mirror are designed to provide forward, backward, and nadir look capability, which minimizes shadowing and ensures data capture even on very steep slopes. The system is capable of logging more than 10 simultaneous pulses in the air, which allows data collection at extremely high resolution while maintaining very high altitude which reduces complete region acquisition time significantly, and allows data collection over terrain with extreme elevation variation. Our experience to-date includes acquisition of data over terrain relief of more than 3500m, and ranges of up to 6000m in a single swath. We present data acquired during spring of 2013 and 2014 in western Colorado and the central Sierra Nevada, which demonstrates the capability of the new LiDAR technology and shows basin-wide measured snow depth and SWE results.

Developing a global health diplomacy supply chain--a viable option for the United States to curb extremism.

PubMed

Kumar, Sameer; Honkanen, Erik J; Karl, Chad C

2009-01-01

This study examines the idea of developing a global health diplomacy supply chain as an important foreign policy approach with the aim of improving the lives of vulnerable populations and serving the best interests of the United States. The study was based on the review of academic literature, news events, and military communiques, and historical writings were studied to determine the feasibility of the idea and the extent of costs and benefits of such an endeavor. An integrated strategic business model, supported by a medical care delivery process, was developed to create a framework for a feasible global health diplomacy supply chain. The findings indicate that extremism can be contained by creating and efficiently executing an effective supply chain to get medical care units to those that need them. The limitations are the potential exit strategies required, the tactical abilities, and diplomatic techniques needed in order to create positive diplomatic change in aid distribution. Managers must consider how supply chains will affect other organizations giving aid and the potential public response. Moreover, determining the level of care necessary to achieve the greatest positive health diplomacy continues to require vigilant scrutiny over the potential cost/benefit analysis. The analysis is valuable to policymakers considering the impacts of health diplomacy by utilizing supply chain management.

Disaster Risks Reduction for Extreme Natural Hazards

NASA Astrophysics Data System (ADS)

Plag, H.; Jules-Plag, S.

2013-12-01

Mega disasters associated with extreme natural hazards have the potential to escalate the global sustainability crisis and put us close to the boundaries of the safe operating space for humanity. Floods and droughts are major threats that potentially could reach planetary extent, particularly through secondary economic and social impacts. Earthquakes and tsunamis frequently cause disasters that eventually could exceed the immediate coping capacity of the global economy, particularly since we have built mega cities in hazardous areas that are now ready to be harvested by natural hazards. Unfortunately, the more we learn to cope with the relatively frequent hazards (50 to 100 years events), the less we are worried about the low-probability, high-impact events (a few hundred and more years events). As a consequence, threats from the 500 years flood, drought, volcano eruption are not appropriately accounted for in disaster risk reduction (DRR) discussions. Extreme geohazards have occurred regularly throughout the past, but mostly did not cause major disasters because exposure of human assets to hazards was much lower in the past. The most extreme events that occurred during the last 2,000 years would today cause unparalleled damage on a global scale and could worsen the sustainability crisis. Simulation of these extreme hazards under present conditions can help to assess the disaster risk. Recent extreme earthquakes have illustrated the destruction they can inflict, both directly and indirectly through tsunamis. Large volcano eruptions have the potential to impact climate, anthropogenic infrastructure and resource supplies on global scale. During the last 2,000 years several large volcano eruptions occurred, which under today's conditions are associated with extreme disaster risk. The comparison of earthquakes and volcano eruptions indicates that large volcano eruptions are the low-probability geohazards with potentially the highest impact on our civilization. Integration of these low-probability, high-impact events in DRR requires an approach focused on resilience and antifragility, as well as the ability to cope with, and recover from failure of infrastructure and social systems. Resilience does not primarily result from the robustness of infrastructure but mainly is a function of the social capital. While it is important to understand the hazards (the contribution of geosciences), it is equally important to understand the processes that let us cope with the hazards, or lead to failure (the contribution of social sciences and engineering). For the latter, we need a joint effort of social sciences and engineering and a revised science-policy relationship. Democratizing knowledge about extreme geohazards is very important in order to inform deliberations of DRR through increased resilience and reduced fragility. The current science-society dialog is not fully capable of supporting deliberative governance. Most scientific knowledge is created independent of those who could put it to use, and a transition to co-design and co-development of knowledge involving a broad stakeholder base is necessary for DRR, particularly for extreme events. This transition may have the consequence of more responsibility and even liability for science.

Predicting Likelihood of Surgery Prior to First Visit in Patients with Back and Lower Extremity Symptoms: A simple mathematical model based on over 8000 patients.

PubMed

Boden, Lauren M; Boden, Stephanie A; Premkumar, Ajay; Gottschalk, Michael B; Boden, Scott D

2018-02-09

Retrospective analysis of prospectively collected data. To create a data-driven triage system stratifying patients by likelihood of undergoing spinal surgery within one year of presentation. Low back pain (LBP) and radicular lower extremity (LE) symptoms are common musculoskeletal problems. There is currently no standard data-derived triage process based on information that can be obtained prior to the initial physician-patient encounter to direct patients to the optimal physician type. We analyzed patient-reported data from 8006 patients with a chief complaint of LBP and/or LE radicular symptoms who presented to surgeons at a large multidisciplinary spine center between September 1, 2005 and June 30, 2016. Univariate and multivariate analysis identified independent risk factors for undergoing spinal surgery within one year of initial visit. A model incorporating these risk factors was created using a random sample of 80% of the total patients in our cohort, and validated on the remaining 20%. The baseline one-year surgery rate within our cohort was 39% for all patients and 42% for patients with LE symptoms. Those identified as high likelihood by the center's existing triage process had a surgery rate of 45%. The new triage scoring system proposed in this study was able to identify a high likelihood group in which 58% underwent surgery, which is a 46% higher surgery rate than in non-triaged patients and a 29% improvement from our institution's existing triage system. The data-driven triage model and scoring system derived and validated in this study (Spine Surgery Likelihood model [SSL-11]), significantly improved existing processes in predicting the likelihood of undergoing spinal surgery within one year of initial presentation. This triage system will allow centers to more selectively screen for surgical candidates and more effectively direct patients to surgeons or non-operative spine specialists. 4.

Our Magnetic Universe: The Nature of High Polarization Prompt Gamma Ray Bursts and the Origin of Dark Energy

NASA Astrophysics Data System (ADS)

Greyber, Howard D.

2011-01-01

The author's "Strong” Magnetic Field model (SMF), created in 1961, is an approach identical to that urged for study by Zel'dovich in 1983. SMF is described in my 2005 paper, published in the CD of the Proceedings of the 22nd Texas Relativistic Astrophysics Symposium (also existing in Astro-ph0509223). A first order phase transition called the Spinodal Decomposition Instability causes a rapid exponential growth of the fluctuations at Combination Time. One of several important results from SMF is the very early generation, soon after Combination Time, of an intense, relativistic stable "storage current loop” in most active galaxies and quasars that was formed by gravitational collapse of the huge pre-galactic plasma cloud in the presence of the primordial magnetic field. This suggests that gamma ray bursts (GRB) are created, similar to what happens on Earth at an accelerator, by a beam on target (BOT) process. A dense target, like a white dwarf, neutron star, planet, et al, crossing the beam, causes the optical transient or "fireball” that is observed at the site of a gamma ray burst (GRB). The extremely powerful "storage current ring", or loop current, heats the target into a plasma blob. The plasma blob is accelerated, exits the current ring, passing through the enormous ordered magnetic field around the current loop, thus inducing the polarization that has been observed. An Appendix explains the Origin of Dark Energy according to the SMF model, which, uniquely, derives the Origin of Magnetic Fields occurring at Combination Time, (NOT far later when galaxies form, as believed by most astrophysicists for over eight decades), and also uses a comment by Albert Einstein. That result produces the unique Supercluster Topology where almost all the mass is on a shell surrounding an extremely high vacuum, explaining the current Accelerating Expansion observed in our universe.

Denudational slope processes and slope response to global climate changes and other disturbances: insights from the Nepal Himalayas.

NASA Astrophysics Data System (ADS)

Fort, Monique

2016-04-01

Hillslope geomorphology results from a large range of denudational processes mainly controlled by relief, structure, lithology, climate, land-cover and land use. In most areas of the world, the "critical zone" concept is a good integrator of denudation that operates on a long-term scale. However, in large and high mountain areas, short-time scale factors often play a significant role in the denudational pattern, accelerating and/or delaying the transfer of denudation products and fluxes, and creating specific, spatially limited disturbances. We focus on the Nepal Himalayas, where the wide altitudinal range of bio-climatic zones and the intense geodynamic activity create a complex mosaic of landforms, as expressed by the present geomorphology of mountain slopes. On the basis of examples selected in the different Himalayan mountain belts (Siwaliks hills, middle mountains, High Himalaya), we illustrate different types of slopes and disturbances induced by active tectonics, climate extremes, and climate warming trends. Special attention is paid to recent events, such as landslide damming, triggered by either intense rainfalls (Kali Gandaki and Sun Kosi valleys) or the last April-May 2015 Gorkha seismic sequence (southern Khumbu). Lastly, references to older, larger events show that despite the highly dynamic environment, landforms caused by large magnitude disturbances may persist in the landscape in the long term.

Efficient and reusable polyamide-56 nanofiber/nets membrane with bimodal structures for air filtration.

PubMed

Liu, Bowen; Zhang, Shichao; Wang, Xueli; Yu, Jianyong; Ding, Bin

2015-11-01

Nanofibrous media that both possess high airborne particle interception efficiency and robust air permeability would have broad technological implications for areas ranging from individual protection and industrial security to environmental governance; however, creating such filtration media has proved extremely challenging. Here we report a strategy to construct the bio-based polyamide-56 nanofiber/nets (PA-56 NFN) membranes with bimodal structures for effective air filtration via one-step electrospinning/netting. The PA-56 membranes are composed of completely covered two-dimensional (2D) ultrathin (∼20 nm) nanonets which are optimized by facilely regulating the solution concentration, and the bonded scaffold fibers constructed cavity structures which are synchronously created by using the CH3COOH inspiration. With integrated properties of small aperture, high porosity, and bonded scaffold, the resulting PA-56 NFN membranes exhibit high filtration efficiency of 99.995%, low pressure drop of 111 Pa, combined with large dust holding capacity of 49 g/m(2) and dust-cleaning regeneration ability, for filtrating ultrafine airborne particles in the most safe manner involving sieving principle and surface filtration. The successful synthesis of PA-56 NFN medium would not only make it a promising candidate for air filtration, but also provide new insights into the design and development of nanonet-based bimodal structures for various applications. Copyright © 2015 Elsevier Inc. All rights reserved.

Lunar Surface Charging during Solar Energetic Particle Events

NASA Astrophysics Data System (ADS)

Halekas, Jasper S.; Delory, G. T.; Mewaldt, R. A.; Lin, R. P.; Fillingim, M. O.; Brain, D. A.; Lee, C. O.; Stubbs, T. J.; Farrell, W. M.; Hudson, M. K.

2006-09-01

The surface of the Moon, not protected by any substantial atmosphere, is directly exposed to the impact of both solar UV and solar wind plasma and energetic particles. This creates a complex lunar electrostatic environment, with the surface typically charging slightly positive in sunlight, and negative in shadow. Observations from the Apollo era and theoretical considerations strongly suggest that surface charging leads to dust electrification and transport, posing a potentially significant hazard for exploration. The most significant charging effects should occur when the Moon is exposed to high-temperature plasmas like those encountered in the terrestrial plasmasheet or in solar storms. We now present evidence for kilovolt-scale negative charging of the shadowed lunar surface during solar energetic particle (SEP) events, utilizing data from the Lunar Prospector Electron Reflectometer (LP ER). We find that SEP events are associated with the most extreme lunar surface charging observed during the LP mission - rivaled only by previously reported charging during traversals of the terrestrial plasmasheet. The largest charging event observed by LP is a 4 kV negative surface potential (as compared to typical values of V) during a SEP event in May 1998. We characterize lunar surface charging during several SEP events, and compare to energetic particle measurements from ACE, Wind, and SOHO in order to determine the relationship between SEP events and extreme lunar surface charging. Space weather events are already considered by NASA to be a significant hazard to lunar exploration, due to high-energy ionizing radiation. Our observations demonstrate that plasma interactions with the lunar surface during SEP events, causing extreme surface charging and potentially significant dust electrification and transport, represent an additional hazard associated with space weather.

Not all droughts are created equal: The impacts of interannual drought pattern and magnitude on grassland carbon cycling

USGS Publications Warehouse

Hoover, David L.; Rogers, Brendan M.

2016-01-01

Climate extremes, such as drought, may have immediate and potentially prolonged effects on carbon cycling. Grasslands store approximately one-third of all terrestrial carbon and may become carbon sources during droughts. However, the magnitude and duration of drought-induced disruptions to the carbon cycle, as well as the mechanisms responsible, remain poorly understood. Over the next century, global climate models predict an increase in two types of drought: chronic but subtle ‘press-droughts’, and shorter term but extreme ‘pulse-droughts’. Much of our current understanding of the ecological impacts of drought comes from experimental rainfall manipulations. These studies have been highly valuable, but are often short term and rarely quantify carbon feedbacks. To address this knowledge gap, we used the Community Land Model 4.0 to examine the individual and interactive effects of pulse- and press-droughts on carbon cycling in a mesic grassland of the US Great Plains. A series of modeling experiments were imposed by varying drought magnitude (precipitation amount) and interannual pattern (press- vs. pulse-droughts) to examine the effects on carbon storage and cycling at annual to century timescales. We present three main findings. First, a single-year pulse-drought had immediate and prolonged effects on carbon storage due to differential sensitivities of ecosystem respiration and gross primary production. Second, short-term pulse-droughts caused greater carbon loss than chronic press-droughts when total precipitation reductions over a 20-year period were equivalent. Third, combining pulse- and press-droughts had intermediate effects on carbon loss compared to the independent drought types, except at high drought levels. Overall, these results suggest that interannual drought pattern may be as important for carbon dynamics as drought magnitude and that extreme droughts may have long-lasting carbon feedbacks in grassland ecosystems.

Ultrastrong steel via minimal lattice misfit and high-density nanoprecipitation

NASA Astrophysics Data System (ADS)

Jiang, Suihe; Wang, Hui; Wu, Yuan; Liu, Xiongjun; Chen, Honghong; Yao, Mengji; Gault, Baptiste; Ponge, Dirk; Raabe, Dierk; Hirata, Akihiko; Chen, Mingwei; Wang, Yandong; Lu, Zhaoping

2017-04-01

Next-generation high-performance structural materials are required for lightweight design strategies and advanced energy applications. Maraging steels, combining a martensite matrix with nanoprecipitates, are a class of high-strength materials with the potential for matching these demands. Their outstanding strength originates from semi-coherent precipitates, which unavoidably exhibit a heterogeneous distribution that creates large coherency strains, which in turn may promote crack initiation under load. Here we report a counterintuitive strategy for the design of ultrastrong steel alloys by high-density nanoprecipitation with minimal lattice misfit. We found that these highly dispersed, fully coherent precipitates (that is, the crystal lattice of the precipitates is almost the same as that of the surrounding matrix), showing very low lattice misfit with the matrix and high anti-phase boundary energy, strengthen alloys without sacrificing ductility. Such low lattice misfit (0.03 ± 0.04 per cent) decreases the nucleation barrier for precipitation, thus enabling and stabilizing nanoprecipitates with an extremely high number density (more than 1024 per cubic metre) and small size (about 2.7 ± 0.2 nanometres). The minimized elastic misfit strain around the particles does not contribute much to the dislocation interaction, which is typically needed for strength increase. Instead, our strengthening mechanism exploits the chemical ordering effect that creates backstresses (the forces opposing deformation) when precipitates are cut by dislocations. We create a class of steels, strengthened by Ni(Al,Fe) precipitates, with a strength of up to 2.2 gigapascals and good ductility (about 8.2 per cent). The chemical composition of the precipitates enables a substantial reduction in cost compared to conventional maraging steels owing to the replacement of the essential but high-cost alloying elements cobalt and titanium with inexpensive and lightweight aluminium. Strengthening of this class of steel alloy is based on minimal lattice misfit to achieve maximal precipitate dispersion and high cutting stress (the stress required for dislocations to cut through coherent precipitates and thus produce plastic deformation), and we envisage that this lattice misfit design concept may be applied to many other metallic alloys.

Ultrastrong steel via minimal lattice misfit and high-density nanoprecipitation.

PubMed

Jiang, Suihe; Wang, Hui; Wu, Yuan; Liu, Xiongjun; Chen, Honghong; Yao, Mengji; Gault, Baptiste; Ponge, Dirk; Raabe, Dierk; Hirata, Akihiko; Chen, Mingwei; Wang, Yandong; Lu, Zhaoping

2017-04-27

Next-generation high-performance structural materials are required for lightweight design strategies and advanced energy applications. Maraging steels, combining a martensite matrix with nanoprecipitates, are a class of high-strength materials with the potential for matching these demands. Their outstanding strength originates from semi-coherent precipitates, which unavoidably exhibit a heterogeneous distribution that creates large coherency strains, which in turn may promote crack initiation under load. Here we report a counterintuitive strategy for the design of ultrastrong steel alloys by high-density nanoprecipitation with minimal lattice misfit. We found that these highly dispersed, fully coherent precipitates (that is, the crystal lattice of the precipitates is almost the same as that of the surrounding matrix), showing very low lattice misfit with the matrix and high anti-phase boundary energy, strengthen alloys without sacrificing ductility. Such low lattice misfit (0.03 ± 0.04 per cent) decreases the nucleation barrier for precipitation, thus enabling and stabilizing nanoprecipitates with an extremely high number density (more than 10 24 per cubic metre) and small size (about 2.7 ± 0.2 nanometres). The minimized elastic misfit strain around the particles does not contribute much to the dislocation interaction, which is typically needed for strength increase. Instead, our strengthening mechanism exploits the chemical ordering effect that creates backstresses (the forces opposing deformation) when precipitates are cut by dislocations. We create a class of steels, strengthened by Ni(Al,Fe) precipitates, with a strength of up to 2.2 gigapascals and good ductility (about 8.2 per cent). The chemical composition of the precipitates enables a substantial reduction in cost compared to conventional maraging steels owing to the replacement of the essential but high-cost alloying elements cobalt and titanium with inexpensive and lightweight aluminium. Strengthening of this class of steel alloy is based on minimal lattice misfit to achieve maximal precipitate dispersion and high cutting stress (the stress required for dislocations to cut through coherent precipitates and thus produce plastic deformation), and we envisage that this lattice misfit design concept may be applied to many other metallic alloys.

Extreme Weather and Climate: Workshop Report

NASA Technical Reports Server (NTRS)

Sobel, Adam; Camargo, Suzana; Debucquoy, Wim; Deodatis, George; Gerrard, Michael; Hall, Timothy; Hallman, Robert; Keenan, Jesse; Lall, Upmanu; Levy, Marc;

Mechanically robust and transparent N-halamine grafted PVA-co-PE films with renewable antimicrobial activity

USDA-ARS?s Scientific Manuscript database

Antimicrobial polymeric films that are both mechanically robust and function renewable would have broad technological implications for areas ranging from medical safety and bioengineering to foods industry; however, creating such materials has proven extremely challenging. Here, a novel strategy is ...

Using community partners to deliver low-cost and effective emergency management and business continuity services.

PubMed

Thomas, Joan; Roggiero, Jean Paul; Silva, Brian

2010-11-01

Small to medium-sized organisations enhance their business mission as well as their communities by continuing to offer services in extreme circumstances. Developing emergency preparedness and business continuity plans that are cost-effective, comprehensive and operational for small to medium-sized organisations with limited resources requires a consistent, supportive, hands-on approach over time with professionals to create appropriate and sustainable strategies. Using a unique, multi-layered and applied approach to emergency preparedness training, organisations have successfully created plans that are effective and sustainable.

Evaluating performance of biomedical image retrieval systems – an overview of the medical image retrieval task at ImageCLEF 2004–2013

PubMed Central

Kalpathy-Cramer, Jayashree; de Herrera, Alba García Seco; Demner-Fushman, Dina; Antani, Sameer; Bedrick, Steven; Müller, Henning

2014-01-01

Medical image retrieval and classification have been extremely active research topics over the past 15 years. With the ImageCLEF benchmark in medical image retrieval and classification a standard test bed was created that allows researchers to compare their approaches and ideas on increasingly large and varied data sets including generated ground truth. This article describes the lessons learned in ten evaluations campaigns. A detailed analysis of the data also highlights the value of the resources created. PMID:24746250

On high heels and short muscles: A multiscale model for sarcomere loss in the gastrocnemius muscle

PubMed Central

Zöllner, Alexander M.; Pok, Jacquelynn M.; McWalter, Emily J.; Gold, Garry E.; Kuhl, Ellen

2014-01-01

High heels are a major source of chronic lower limb pain. Yet, more than one third of all women compromise health for looks and wear high heels on a daily basis. Changing from flat footwear to high heels induces chronic muscle shortening associated with discomfort, fatigue, reduced shock absorption, and increased injury risk. However, the long-term effects of high-heeled footwear on the musculoskeletal kinematics of the lower extremities remain poorly understood. Here we create a multiscale computational model for chronic muscle adaptation to characterize the acute and chronic effects of global muscle shortening on local sarcomere lengths. We perform a case study of a healthy female subject and show that raising the heel by 13 cm shortens the gastrocnemius muscle by 5% while the Achilles tendon remains virtually unaffected. Our computational simulation indicates that muscle shortening displays significant regional variations with extreme values of 22% in the central gastrocnemius. Our model suggests that the muscle gradually adjusts to its new functional length by a chronic loss of sarcomeres in series. Sarcomere loss varies significantly across the muscle with an average loss of 9%, virtually no loss at the proximal and distal ends, and a maximum loss of 39% in the central region. These changes reposition the remaining sarcomeres back into their optimal operating regime. Computational modeling of chronic muscle shortening provides a valuable tool to shape our understanding of the underlying mechanisms of muscle adaptation. Our study could open new avenues in orthopedic surgery and enhance treatment for patients with muscle contracture caused by other conditions than high heel wear such as paralysis, muscular atrophy, and muscular dystrophy. PMID:25451524

Computational discovery of extremal microstructure families

PubMed Central

Chen, Desai; Skouras, Mélina; Zhu, Bo; Matusik, Wojciech

2018-01-01

Modern fabrication techniques, such as additive manufacturing, can be used to create materials with complex custom internal structures. These engineered materials exhibit a much broader range of bulk properties than their base materials and are typically referred to as metamaterials or microstructures. Although metamaterials with extraordinary properties have many applications, designing them is very difficult and is generally done by hand. We propose a computational approach to discover families of microstructures with extremal macroscale properties automatically. Using efficient simulation and sampling techniques, we compute the space of mechanical properties covered by physically realizable microstructures. Our system then clusters microstructures with common topologies into families. Parameterized templates are eventually extracted from families to generate new microstructure designs. We demonstrate these capabilities on the computational design of mechanical metamaterials and present five auxetic microstructure families with extremal elastic material properties. Our study opens the way for the completely automated discovery of extremal microstructures across multiple domains of physics, including applications reliant on thermal, electrical, and magnetic properties. PMID:29376124

High-performance functional ecopolymers based on flora and fauna.

PubMed

Kaneko, Tatsuo

2007-01-01

Liquid crystalline (LC) polymers of rigid monomers based on flora and fauna were prepared by in-bulk polymerization. Para-coumaric (p-coumaric) acid [4-hydroxycinnamic acid (4HCA)] and its derivatives were selected as phytomonomers and bile acids were selected as biomonomers. The 4HCA homopolymer showed a thermotropic LC phase only in a state of low molecular weight. The copolymers of 4HCA with bile acids such as lithocholic acid (LCA) and cholic acid (CA) showed excellent cell compatibilities but low molecular weights. However, P(4HCA-co-CA)s allowed LC spinning to create molecularly oriented biofibers, presumably due to the chain entanglement that occurs during in-bulk chain propagation into hyperbranching architecture. P[4HCA-co-3,4-dihydroxycinnamic acid (DHCA)]s showed high molecular weight, high mechanical strength, high Young's modulus, and high softening temperature, which may be achieved through the entanglement by in-bulk formation of hyperbranching, rigid structures. P(4HCA-co-DHCA)s showed a smooth hydrolysis, in-soil degradation, and photo-tunable hydrolysis. Thus, P(4HCA-co-DHCA)s might be applied as an environmentally degradable plastic with extremely high performance.

High thermal conductivity in soft elastomers with elongated liquid metal inclusions

PubMed Central

Bartlett, Michael D.; Powell-Palm, Matthew J.; Huang, Xiaonan; Sun, Wenhuan; Malen, Jonathan A.; Majidi, Carmel

2017-01-01

Soft dielectric materials typically exhibit poor heat transfer properties due to the dynamics of phonon transport, which constrain thermal conductivity (k) to decrease monotonically with decreasing elastic modulus (E). This thermal−mechanical trade-off is limiting for wearable computing, soft robotics, and other emerging applications that require materials with both high thermal conductivity and low mechanical stiffness. Here, we overcome this constraint with an electrically insulating composite that exhibits an unprecedented combination of metal-like thermal conductivity, an elastic compliance similar to soft biological tissue (Young’s modulus < 100 kPa), and the capability to undergo extreme deformations (>600% strain). By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ∼25× increase in thermal conductivity (4.7 ± 0.2 W⋅m−1⋅K−1) over the base polymer (0.20 ± 0.01 W⋅m−1·K−1) under stress-free conditions and a ∼50× increase (9.8 ± 0.8 W⋅m−1·K−1) when strained. This exceptional combination of thermal and mechanical properties is enabled by a unique thermal−mechanical coupling that exploits the deformability of the LM inclusions to create thermally conductive pathways in situ. Moreover, these materials offer possibilities for passive heat exchange in stretchable electronics and bioinspired robotics, which we demonstrate through the rapid heat dissipation of an elastomer-mounted extreme high-power LED lamp and a swimming soft robot. PMID:28193902

High thermal conductivity in soft elastomers with elongated liquid metal inclusions.

NASA Astrophysics Data System (ADS)

Kazem, Navid; Bartlett, Michael D.; Powell-Palm, Matthew J.; Huang, Xiaonan; Sun, Wenhuan; Malen, Jonathan A.; Majidi, Carmel

Soft dielectric materials typically exhibit poor heat transfer properties due to the dynamics of phonon transport, which constrains thermal conductivity (k) to decrease monotonically with decreasing elastic modulus (E) . This is limiting for wearable computing, soft robotics, and other emerging applications that require materials with both high thermal conductivity and low mechanical stiffness. Here, we overcome this constraint with a dielectric composite that exhibits an unprecedented combination of metal-like thermal conductivity, an elastic compliance similar to soft biological tissue (E <100kPa), and extreme deformations capability (>600% strain). By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a 25x increase in thermal conductivity (4.7 +/-0.2 W/mK) over the base polymer (0.20 +/-0.01 W/mK) under stress-free conditions and a 50x increase (9.8 +/-0.8 W/mK) when strained. This exceptional combination of thermal and mechanical properties is through the deformation of the LM inclusions to create thermally conductive pathways in situ. Moreover, these materials offer new possibilities for passive heat exchange in stretchable electronics and bio-inspired robotics, which we demonstrate through the rapid heat dissipation of an elastomer-mounted extreme high power LED lamp and a swimming soft robot. AFOSR Young Investigator Program (Mechanics of Multifunctional Materials and Microsystems; Dr. Les Lee; FA9550-13-1-0123), NASA Early Career Faculty Award (NNX14AO49G), Army Research Office Grant W911NF-14-0350.

A TinyOS-enabled MICA2-based wireless neural interface.

PubMed

Farshchi, Shahin; Nuyujukian, Paul H; Pesterev, Aleksey; Mody, Istvan; Judy, Jack W

2006-07-01

Existing approaches used to develop compact low-power multichannel wireless neural recording systems range from creating custom-integrated circuits to assembling commercial-off-the-shelf (COTS) PC-based components. Custom-integrated-circuit designs yield extremely compact and low-power devices at the expense of high development and upgrade costs and turn-around times, while assembling COTS-PC-technology yields high performance at the expense of large system size and increased power consumption. To achieve a balance between implementing an ultra-compact custom-fabricated neural transceiver and assembling COTS-PC-technology, an overlay of a neural interface upon the TinyOS-based MICA2 platform is described. The system amplifies, digitally encodes, and transmits neural signals real-time at a rate of 9.6 kbps, while consuming less than 66 mW of power. The neural signals are received and forwarded to a client PC over a serial connection. This data rate can be divided for recording on up to 6 channels, with a resolution of 8 bits/sample. This work demonstrates the strengths and limitations of the TinyOS-based sensor technology as a foundation for chronic remote biological monitoring applications and, thus, provides an opportunity to create a system that can leverage from the frequent networking and communications advancements being made by the global TinyOS-development community.

Compact, Low-Profile Power Converters: Highly-Laminated, High-Saturation-Flux-Density, Magnetic Cores for On-Chip Inductors in Power Converter Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-09-01

ADEPT Project: Georgia Tech is creating compact, low-profile power adapters and power bricks using materials and tools adapted from other industries and from grid-scale power applications. Adapters and bricks convert electrical energy into useable power for many types of electronic devices, including laptop computers and mobile phones. These converters are often called wall warts because they are big, bulky, and sometimes cover up an adjacent wall socket that could be used to power another electronic device. The magnetic components traditionally used to make adapters and bricks have reached their limits; they can't be made any smaller without sacrificing performance. Georgiamore » Tech is taking a cue from grid-scale power converters that use iron alloys as magnetic cores. These low-cost alloys can handle more power than other materials, but the iron must be stacked in insulated plates to maximize energy efficiency. In order to create compact, low-profile power adapters and bricks, these stacked iron plates must be extremely thin-only hundreds of nanometers in thickness, in fact. To make plates this thin, Georgia Tech is using manufacturing tools used in microelectromechanics and other small-scale industries.« less

Volumetric Heating of Ultra-High Energy Density Relativistic Plasmas by Ultrafast Laser Irradiation of Aligned Nanowire Arrays

NASA Astrophysics Data System (ADS)

Bargsten, Clayton; Hollinger, Reed; Shlyaptsev, Vyacheslav; Pukhov, Alexander; Keiss, David; Townsend, Amanda; Wang, Yong; Wang, Shoujun; Prieto, Amy; Rocca, Jorge

2014-10-01

We have demonstrated the volumetric heating of near-solid density plasmas to keV temperatures by ultra-high contrast femtosecond laser irradiation of arrays of vertically aligned nanowires with an average density up to 30% solid density. X-ray spectra show that irradiation of Ni and Au nanowire arrays with laser pulses of relativistic intensities ionizes plasma volumes several micrometers in depth to the He-like and Co-like (Au 52 +) stages respectively. The penetration depth of the heat into the nanowire array was measured monitoring He-like Co lines from irradiated arrays in which the nanowires are composed of a Co segment buried under a selected length of Ni. The measurement shows the ionization reaches He-like Co for depth of up to 5 μm within the target. This volumetric plasma heating approach creates a new laboratory plasma regime in which extreme plasma parameters can be accessed with table-top lasers. Scaling to higher laser intensities promises to create plasmas with temperatures and pressures approaching those in the center of the sun. Work supported by the U.S Department of Energy, Fusion Energy Sciences and the Defense Threat Reduction Agency grant HDTRA-1-10-1-0079. A.P was supported by of DFG-funded project TR18.

Hydrometeorological extremes reconstructed from documentary evidence for the Jihlava region in the 17th-19th centuries

NASA Astrophysics Data System (ADS)

Dolak, Lukas; Brazdil, Rudolf; Chroma, Katerina; Valasek, Hubert; Belinova, Monika; Reznickova, Ladislava

2016-04-01

Different documentary evidence (taxation records, chronicles, insurance reports etc.) is used for reconstruction of hydrometeorological extremes (HMEs) in the Jihlava region (central part of the recent Czech Republic) in the 17th-19th centuries. The aim of the study is description of the system of tax alleviation in Moravia, presentation of utilization of early fire and hail damage insurance claims and application of the new methodological approaches for the analysis of HMEs impacts. During the period studied more than 400 HMEs were analysed for the 16 estates (past basic economic units). Late frost on 16 May 1662 on the Nove Mesto na Morave estate, which destroyed whole cereals and caused damage in the forests, is the first recorded extreme event. Downpours causing flash floods and hailstorms are the most frequently recorded natural disasters. Moreover, floods, droughts, windstorms, blizzards, late frosts and lightning strikes starting fires caused enormous damage as well. The impacts of HMEs are classified into three categories: impacts on agricultural production, material property and the socio-economic impacts. Natural disasters became the reasons of losses of human lives, property, supplies and farming equipment. HMEs caused damage to fields and meadows, depletion of livestock and triggered the secondary consequences as lack of seeds and finance, high prices, indebtedness, poverty and deterioration in field fertility. The results are discussed with respect to uncertainties associated with documentary evidences and their spatiotemporal distribution. Archival records, preserved in the Moravian Land Archives in Brno and other district archives, create a unique source of data contributing to the better understanding of extreme events and their impacts.

Volitional Spine Stabilization During a Drop Vertical Jump From Different Landing Heights: Implications for Anterior Cruciate Ligament Injury.

PubMed

Haddas, Ram; Hooper, Troy; James, C Roger; Sizer, Phillip S

2016-12-01

Volitional preemptive abdominal contraction (VPAC) during dynamic activities may alter trunk motion, but the role of the core musculature in positioning the trunk during landing tasks is unclear. To determine whether volitional core-muscle activation incorporated during a drop vertical jump alters lower extremity kinematics and kinetics, as well as trunk and lower extremity muscle activity at different landing heights. Controlled laboratory study. Clinical biomechanics laboratory. Thirty-two young healthy adults, consisting of 17 men (age = 25.24 ± 2.88 years, height = 1.85 ± 0.06 m, mass = 89.68 ± 16.80 kg) and 15 women (age = 23.93 ± 1.33 years, height = 1.67 ± 0.08 m, mass = 89.68 ± 5.28 kg). Core-muscle activation using VPAC. We collected 3-dimensional ankle, knee, and hip motions, moments, and powers; ground reaction forces; and trunk and lower extremity muscle activity during 0.30- and 0.50-m drop vertical-jump landings. During landing from a 0.30-m height, VPAC performance increased external oblique and semitendinosis activity, knee flexion, and knee internal rotation and decreased knee-abduction moment and knee-energy absorption. During the 0.50-m landing, the VPAC increased external oblique and semitendinosis activity, knee flexion, and hip flexion and decreased ankle inversion and hip-energy absorption. The VPAC performance during landing may protect the anterior cruciate ligament during different landing phases from different heights, creating a protective advantage just before ground contact and after the impact phase. Incorporating VPAC during high injury-risk activities may enhance pelvic stability, improve lower extremity positioning and sensorimotor control, and reduce anterior cruciate ligament injury risk while protecting the lumbar spine.

XFEL resonant photo-pumping of dense plasmas and dynamic evolution of autoionizing core hole states

NASA Astrophysics Data System (ADS)

Rosmej, F. B.; Moinard, A.; Renner, O.; Galtier, E.; Lee, J. J.; Nagler, B.; Heimann, P. A.; Schlotter, W.; Turner, J. J.; Lee, R. W.; Makita, M.; Riley, D.; Seely, J.

2016-03-01

Similarly to the case of LIF (Laser-Induced Fluorescence), an equally revolutionary impact to science is expected from resonant X-ray photo-pumping. It will particularly contribute to a progress in high energy density science: pumped core hole states create X-ray transitions that can escape dense matter on a 10 fs-time scale without essential photoabsorption, thus providing a unique possibility to study matter under extreme conditions. In the first proof of principle experiment at the X-ray Free Electron Laser LCLS at SCLAC [Seely, J., Rosmej, F.B., Shepherd, R., Riley, D., Lee, R.W. Proposal to Perform the 1st High Energy Density Plasma Spectroscopic Pump/Probe Experiment”, approved LCLS proposal L332 (2010)] we have successfully pumped inner-shell X-ray transitions in dense plasmas. The plasma was generated with a YAG laser irradiating solid Al and Mg targets attached to a rotating cylinder. In parallel to the optical laser beam, the XFEL was focused into the plasma plume at different delay times and pump energies. Pumped X-ray transitions have been observed with a spherically bent crystal spectrometer coupled to a Princeton CCD. By using this experimental configuration, we have simultaneously achieved extremely high spectral (λ/δλ ≈ 5000) and spatial resolution (δx≈70 μm) while maintaining high luminosity and a large spectral range covered (6.90 - 8.35 Å). By precisely measuring the variations in spectra emitted from plasma under action of XFEL radiation, we have successfully demonstrated transient X- ray pumping in a dense plasma.

Subtle design changes control the difference in colour reflection from the dorsal and ventral wing-membrane surfaces of the damselfly Matronoides cyaneipennis.

PubMed

Nixon, M R; Orr, A G; Vukusic, P

2013-01-28

The hind wings of males of the damselfly Matronoides cyaneipennis exhibit iridescence that is blue dorsally and green ventrally. These structures are used semiotically in agonistic and courtship display. Transmission electron microscopy reveals these colours are due to two near-identical 5-layer distributed Bragg reflectors, one placed either side of the wing membrane. Interestingly the thicknesses of corresponding layers in each distributed Bragg reflector are very similar for all but the second layer from each outer surface. This one key difference creates the significant disparity between the reflected spectra from the distributed Bragg reflectors and the observed colours of either side of the wing. Modelling indicates that modifications to the thickness of this layer alone create a greater change in the peak reflected wavelength than is observed for similar modifications to the thickness of any other layer. This results in an optimised and highly effective pair of semiotic reflector systems, based on extremely comparable design parameters, with relatively low material and biomechanical costs.

X-Ray Emission from the Terrestrial Magnetosheath

NASA Astrophysics Data System (ADS)

Robertson, I. P.; Collier, M. R.; Cravens, T. E.; Fok, M.

2004-12-01

X-rays are generated throughout the terrestrial magnetosheath as a consequence of charge transfer collisions between heavy solar wind ions and geocoronal neutrals. The solar wind ions resulting from these collisions are left in highly excited states and emit extreme ultraviolet or soft X-ray photons. A model has been created to simulate this X-ray radiation. Previously simulated images were created as seen from an observation point outside the geocorona. The locations of the bow shock and magnetopause were evident in these images. The cusps, however, were not taken into account in the model. We have now used dynamic three-dimensional simulations of the solar wind, magnetosheath and magnetosphere that were performed by the CCMC at Goddard Space Flight Center for the March 31st , 2001 geomagnetic storm. We have generated a sky map of the expected X-Ray emissions as would have been seen by an observer at the IMAGE space craft location at that time. We have also generated images as seen from an observation point well outside the geocorona. In both cases the presence of the cusps can clearly be observed.

Climate Change: A New Metric to Measure Changes in the Frequency of Extreme Temperatures using Record Data

NASA Technical Reports Server (NTRS)

Munasinghe, L.; Jun, T.; Rind, D. H.

2012-01-01

Consensus on global warming is the result of multiple and varying lines of evidence, and one key ramification is the increase in frequency of extreme climate events including record high temperatures. Here we develop a metric- called "record equivalent draws" (RED)-based on record high (low) temperature observations, and show that changes in RED approximate changes in the likelihood of extreme high (low) temperatures. Since we also show that this metric is independent of the specifics of the underlying temperature distributions, RED estimates can be aggregated across different climates to provide a genuinely global assessment of climate change. Using data on monthly average temperatures across the global landmass we find that the frequency of extreme high temperatures increased 10-fold between the first three decades of the last century (1900-1929) and the most recent decade (1999-2008). A more disaggregated analysis shows that the increase in frequency of extreme high temperatures is greater in the tropics than in higher latitudes, a pattern that is not indicated by changes in mean temperature. Our RED estimates also suggest concurrent increases in the frequency of both extreme high and extreme low temperatures during 2002-2008, a period when we observe a plateauing of global mean temperature. Using daily extreme temperature observations, we find that the frequency of extreme high temperatures is greater in the daily minimum temperature time-series compared to the daily maximum temperature time-series. There is no such observable difference in the frequency of extreme low temperatures between the daily minimum and daily maximum.

Detection of photosynthetic responses of cool-temperate forests following extreme climate events using Bayesian inversion

NASA Astrophysics Data System (ADS)

Toda, M.; Knohl, A.; Herbst, M.; Keenan, T. F.; Yokozawa, M.

2016-12-01

The increase in extreme climate events associated with ongoing global warming may create severe damage to terrestrial ecosystems, changing plant structure and the eco-physiological functions that regulate ecosystem carbon exchange. However, most damage is usually due to moderate, rather than catastrophic, disturbances. The nature of plant functional responses to such disturbances, and the resulting effects on the terrestrial carbon cycle, remain poorly understood. To unravel the scientific question, tower-based eddy covariance data in the cool-temperate forests were used to constrain plant eco-physiological parameters in a persimoneous ecosystem model that may have affected carbon dynamics following extreme climate events using the statistic Bayesian inversion approach. In the present study, we raised two types of extreme events relevant for cool-temperate regions, i.e. a typhoon with mechanistic foliage destraction and a heat wave with severe drought. With appropriate evaluation of parameter and predictive uncertainties, the inversion analysis shows annual trajectory of activated photosynthetic responses following climate extremes compared the pre-disturbance state in each forest. We address that forests with moderate disturbance show substantial and rapid photosynthetic recovery, enhanced productivity, and, thus, ecosystem carbon exchange, although the effect of extreme climatic events varies depending on the stand successional phase and the type, intensity, timing and legacy of the disturbance.

The scaling of population persistence with carrying capacity does not asymptote in populations of a fish experiencing extreme climate variability.

PubMed

White, Richard S A; Wintle, Brendan A; McHugh, Peter A; Booker, Douglas J; McIntosh, Angus R

2017-06-14

Despite growing concerns regarding increasing frequency of extreme climate events and declining population sizes, the influence of environmental stochasticity on the relationship between population carrying capacity and time-to-extinction has received little empirical attention. While time-to-extinction increases exponentially with carrying capacity in constant environments, theoretical models suggest increasing environmental stochasticity causes asymptotic scaling, thus making minimum viable carrying capacity vastly uncertain in variable environments. Using empirical estimates of environmental stochasticity in fish metapopulations, we showed that increasing environmental stochasticity resulting from extreme droughts was insufficient to create asymptotic scaling of time-to-extinction with carrying capacity in local populations as predicted by theory. Local time-to-extinction increased with carrying capacity due to declining sensitivity to demographic stochasticity, and the slope of this relationship declined significantly as environmental stochasticity increased. However, recent 1 in 25 yr extreme droughts were insufficient to extirpate populations with large carrying capacity. Consequently, large populations may be more resilient to environmental stochasticity than previously thought. The lack of carrying capacity-related asymptotes in persistence under extreme climate variability reveals how small populations affected by habitat loss or overharvesting, may be disproportionately threatened by increases in extreme climate events with global warming. © 2017 The Author(s).

Using Digital Storytelling to Improve Literacy Skills

ERIC Educational Resources Information Center

Menezes, Helena

2012-01-01

The paper shows the importance of Storybird, an online platform, for developing writing and storytelling among young learners of a foreign language. Storybird is an extremely engaging collaborative storywriting website that embodies three ideas--creating, reading, and sharing. It is also a collaborative storytelling tool that allows students to…

Internationally Yours: Writing and Communicating Successfully in Today's Global Marketplace.

ERIC Educational Resources Information Center

De Vries, Mary A.

Intended to help international business people create business documents of style and substance for correspondents in many different cultures (correspondents whose second or even third language is English), this guide is extremely useful for the millions who travel internationally, work abroad, and correspond with business people in other…

Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes.

PubMed

Castoe, Todd A; de Koning, Jason A P; Hall, Kathryn T; Yokoyama, Ken D; Gu, Wanjun; Smith, Eric N; Feschotte, Cédric; Uetz, Peter; Ray, David A; Dobry, Jason; Bogden, Robert; Mackessy, Stephen P; Bronikowski, Anne M; Warren, Wesley C; Secor, Stephen M; Pollock, David D

2011-07-28

The Consortium for Snake Genomics is in the process of sequencing the genome and creating transcriptomic resources for the Burmese python. Here, we describe how this will be done, what analyses this work will include, and provide a timeline.

Re-Casting the U.S.-Mexico Border Security Net

DTIC Science & Technology

2014-03-01

the best fence money can buy , and they counter us with a 2,500-year-old technology.214 The incident proved that these organizations are extremely...created a demand that has attracted illicit activity. DTOs have expanded their franchises to increase the size of their profits. Border security

A Recruiting and Hiring Role-Play: An Experiential Simulation

ERIC Educational Resources Information Center

Newberry, Robert; Collins, Marianne K.

2012-01-01

Creating experiential learning opportunities that engage students, meet marketing curricula objectives, and fit the application in a traditional semester course is extremely challenging. This paper describes a role-playing simulation offered concurrently to the professional selling and sales management classes in which the selling students act as…

Sustainability Adult Education: Learning to Re-Create the World

ERIC Educational Resources Information Center

Griswold, Wendy

2016-01-01

No crisis is as great as the environmental predicament we face. Globally, humans everywhere now confront problems of extreme weather, waste disposal, pollution, overpopulation, massive forest depletion, access to clean water, the depletion of natural resources, the destruction of natural habitats, and changes in the chemistry of the world's…

One-step synthesis of highly efficient nanocatalysts on the supports with hierarchical pores using porous ionic liquid-water gel.

PubMed

Kang, Xinchen; Zhang, Jianling; Shang, Wenting; Wu, Tianbin; Zhang, Peng; Han, Buxing; Wu, Zhonghua; Mo, Guang; Xing, Xueqing

2014-03-12

Stable porous ionic liquid-water gel induced by inorganic salts was created for the first time. The porous gel was used to develop a one-step method to synthesize supported metal nanocatalysts. Au/SiO2, Ru/SiO2, Pd/Cu(2-pymo)2 metal-organic framework (Cu-MOF), and Au/polyacrylamide (PAM) were synthesized, in which the supports had hierarchical meso- and macropores, the size of the metal nanocatalysts could be very small (<1 nm), and the size distribution was very narrow even when the metal loading amount was as high as 8 wt %. The catalysts were extremely active, selective, and stable for oxidative esterification of benzyl alcohol to methyl benzoate, benzene hydrogenation to cyclohexane, and oxidation of benzyl alcohol to benzaldehyde because they combined the advantages of the nanocatalysts of small size and hierarchical porosity of the supports. In addition, this method is very simple.

Fully Convolutional Architecture for Low-Dose CT Image Noise Reduction

NASA Astrophysics Data System (ADS)

Badretale, S.; Shaker, F.; Babyn, P.; Alirezaie, J.

2017-10-01

One of the critical topics in medical low-dose Computed Tomography (CT) imaging is how best to maintain image quality. As the quality of images decreases with lowering the X-ray radiation dose, improving image quality is extremely important and challenging. We have proposed a novel approach to denoise low-dose CT images. Our algorithm learns directly from an end-to-end mapping from the low-dose Computed Tomography images for denoising the normal-dose CT images. Our method is based on a deep convolutional neural network with rectified linear units. By learning various low-level to high-level features from a low-dose image the proposed algorithm is capable of creating a high-quality denoised image. We demonstrate the superiority of our technique by comparing the results with two other state-of-the-art methods in terms of the peak signal to noise ratio, root mean square error, and a structural similarity index.

What's on the Surface? Physics and Chemistry of Delta-Doped Surfaces

NASA Technical Reports Server (NTRS)

Hoenk, Michael

2011-01-01

Outline of presentation: 1. Detector surfaces and the problem of stability 2. Delta-doped detectors 3. Physics of Delta-doped Silicon 4. Chemistry of the Si-SiO2 Interface 5. Physics and Chemistry of Delta-doped Surfaces a. Compensation b. Inversion c. Quantum exclusion. Conclusions: 1. Quantum confinement of electrons and holes dominates the behavior of delta-doped surfaces. 2. Stability of delta-doped detectors: Delta-layer creates an approx 1 eV tunnel barrier between bulk and surface. 3. At high surface charge densities, Tamm-Shockley states form at the surface. 4. Surface passivation by quantum exclusion: Near-surface delta-layer suppresses T-S trapping of minority carriers. 5. The Si-SiO2 interface compensates the surface 6. For delta-layers at intermediate depth, surface inversion layer forms 7. Density of Si-SiO2 interface charge can be extremely high (>10(exp 14)/sq cm)

Social interactions in massively multiplayer online role-playing gamers.

PubMed

Cole, Helena; Griffiths, Mark D

2007-08-01

To date, most research into massively multiplayer online role-playing games (MMORPGs) has examined the demographics of play. This study explored the social interactions that occur both within and outside of MMORPGs. The sample consisted of 912 self-selected MMORPG players from 45 countries. MMORPGs were found to be highly socially interactive environments providing the opportunity to create strong friendships and emotional relationships. The study demonstrated that the social interactions in online gaming form a considerable element in the enjoyment of playing. The study showed MMORPGs can be extremely social games, with high percentages of gamers making life-long friends and partners. It was concluded that virtual gaming may allow players to express themselves in ways they may not feel comfortable doing in real life because of their appearance, gender, sexuality, and/or age. MMORPGs also offer a place where teamwork, encouragement, and fun can be experienced.

Wildfires in Eastern U.S.

NASA Technical Reports Server (NTRS)

2002-01-01

Drought conditions have plagued the Appalachian Mountains in October and November, and low relative humidity combined with dry leaves on the ground has created extreme fire danger in many eastern states. This true-color MODIS image made from data collected on November 13, 2001, shows smoke from numerous fires (indicated in red), predominantly in southern West Virginia (image center), Kentucky (to the southwest), and Tennessee (south). The fires, at least some of which are likely the result of arson, have burned thousands of acres throughout the region. Unfortunately for those people fighting the fires, the fire danger is likely to remain high, with no significant rain expected in the near term. South of Lake Erie, the southernmost of the Great Lakes, numerous aircraft contrails crisscross Ohio. Water vapor emitted with engine exhaust condenses in the cold, dry air at high altitudes, leaving behind a trail of condensation--a contrail. Image courtesy Jacques Descloitres, MODIS Land Rapid Response Team at NASA GSFC

The recreation of a unique shrimp's mechanically induced cavitation bubble

NASA Astrophysics Data System (ADS)

Miller, Ryan; Dougherty, Christopher; Eliasson, Veronica; Khanolkar, Gauri

2014-11-01

The Alpheus heterochaelis, appropriately nicknamed the ``pistol shrimp,'' possesses an oversized claw that creates a cavitation bubble upon rapid closure. The implosion of this bubble results in a shock wave that can stun or even kill the shrimp's prey (Versluis et al., 2000). Additionally, the implosion is so violent that sonoluminescence may occur. This light implies extreme temperatures, which have been recorded to reach as high as 10,000 K (Roach, 2001). By developing an analogous mechanism to the oversized claw, the goal of this experiment is to verify that cavitation can be produced similar to that of the pistol shrimp in nature as well as to analyze the resulting shock wave and sonoluminescence. High-speed schlieren imaging was used to observe the shock dynamics. Furthermore, results on cavitation collapse and light emission will be presented. USC Provost Undergraduate Research Fellowship/Rose Hills Undergraduate Research Fellowship.

Advantageous Use of Hypnosis in a Case of Psychogenic Vomiting.

PubMed

Chandrashekhar, Roopa

2016-04-01

This case study describes in detail the role of hypnosis in treatment of a case of psychogenic vomiting. The patient, a 60-yearold woman, had been suffering for 9 months from episodes of vomiting which resulted in weight loss, dehydration, and hypokalemia. She was a conscientious woman with high standards of behavior, which did not allow an expression of the extreme hostility she felt toward her daughter-in-law. Hypnotherapeutic sessions reduced her anxiety, restored her sleep, improved mood, and helped deepen rapport, all of which created the ideal setting for Gestalt's empty chair technique. Integrating hypnosis greatly enhanced the quality of the empty chair dialogue, which by bringing about a shift in the patient's emotions from hostility to sympathy, facilitated recovery.

Earth Observations taken by the Expedition Seven crew

NASA Image and Video Library

2003-06-14

ISS007-E-07388 (14 June 2003) --- Some of the deepest canyons in the world cut west to the Pacific from the high crest of the Andes Mountains in Peru. This view taken by an Expedition 7 crewmember onboard the International Space Station (ISS) provides a birds-eye view down the canyons of the Rio Camana (center left) and the Rio Ocona (upper right). The low early morning sun highlights the extreme topography created by rapidly uplifting mountains and powerful water erosion by water dropping nearly 10,000 feet in this view. At the edge of the image are the snowy flanks of Nevado Coropuna, the highest mountain in the Cordillera Occidental (6613 meters). The coastal city of Camana is visible in the upper left.

High-throughput microfluidic device for rare cell isolation

NASA Astrophysics Data System (ADS)

Yang, Daniel; Leong, Serena; Lei, Andy; Sohn, Lydia L.

2015-06-01

Enumerating and analyzing circulating tumor cells (CTCs)—cells that have been shed from primary solid tumors—can potentially be used to determine patient prognosis and track the progression of disease. There is a great challenge to create an effective platform that can isolate these cells, as they are extremely rare: only 1-10 CTCs are present in a 7.5mL of a cancer patient's peripheral blood. We have developed a novel microfluidic system that can isolate CTC populations label free. Our system consists of a multistage separator that employs inertial migration to sort cells based on size. We demonstrate the feasibility of our device by sorting colloids that are comparable in size to red blood cells (RBCs) and CTCs.

High-Throughput Microfluidic Device for Rare Cell Isolation.

PubMed

Yang, Daniel; Leong, Serena; Lei, Andy; Sohn, Lydia L

2015-05-04

Enumerating and analyzing circulating tumor cells (CTCs)-cells that have been shed from primary solid tumors-can potentially be used to determine patient prognosis and track the progression of disease. There is a great challenge to create an effective platform that can isolate these cells, as they are extremely rare: only 1-10 CTCs are present in a 7.5mL of a cancer patient's peripheral blood. We have developed a novel microfluidic system that can isolate CTC populations label free. Our system consists of a multistage separator that employs inertial migration to sort cells based on size. We demonstrate the feasibility of our device by sorting colloids that are comparable in size to red blood cells (RBCs) and CTCs.

Mobile Phones Democratize and Cultivate Next-Generation Imaging, Diagnostics and Measurement Tools

PubMed Central

Ozcan, Aydogan

2014-01-01

In this article, I discuss some of the emerging applications and the future opportunities and challenges created by the use of mobile phones and their embedded components for the development of next-generation imaging, sensing, diagnostics and measurement tools. The massive volume of mobile phone users, which has now reached ~7 billion, drives the rapid improvements of the hardware, software and high-end imaging and sensing technologies embedded in our phones, transforming the mobile phone into a cost-effective and yet extremely powerful platform to run e.g., biomedical tests and perform scientific measurements that would normally require advanced laboratory instruments. This rapidly evolving and continuing trend will help us transform how medicine, engineering and sciences are practiced and taught globally. PMID:24647550

A white super-stable source for the metrology of astronomical photometers

NASA Astrophysics Data System (ADS)

Wildi, F. P.; Deline, A.; Chazelas, B.

2015-09-01

The testing of photometers and in particular the testing of high precision photometers for the detection of planetary transits requires a light source which photometric stability is to par or better than the goal stability of the photometer to be tested. In the frame of the CHEOPS mission, a comprehensive calibration bench has been developed. Aside from measuring the sensibility of the CHEOPS payload to the different environmental conditions, this bench will also be used to test the relative accuracy of the payload. A key element of this bench is an extremely stable light source that is used to create an artificial star which is then projected into the payload's telescope. We present here the development of this payload and the performance achieved.

Upper-extremity and mobility subdomains from the Patient-Reported Outcomes Measurement Information System (PROMIS) adult physical functioning item bank.

PubMed

Hays, Ron D; Spritzer, Karen L; Amtmann, Dagmar; Lai, Jin-Shei; Dewitt, Esi Morgan; Rothrock, Nan; Dewalt, Darren A; Riley, William T; Fries, James F; Krishnan, Eswar

2013-11-01

To create upper-extremity and mobility subdomain scores from the Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning adult item bank. Expert reviews were used to identify upper-extremity and mobility items from the PROMIS item bank. Psychometric analyses were conducted to assess empirical support for scoring upper-extremity and mobility subdomains. Data were collected from the U.S. general population and multiple disease groups via self-administered surveys. The sample (N=21,773) included 21,133 English-speaking adults who participated in the PROMIS wave 1 data collection and 640 Spanish-speaking Latino adults recruited separately. Not applicable. We used English- and Spanish-language data and existing PROMIS item parameters for the physical functioning item bank to estimate upper-extremity and mobility scores. In addition, we fit graded response models to calibrate the upper-extremity items and mobility items separately, compare separate to combined calibrations, and produce subdomain scores. After eliminating items because of local dependency, 16 items remained to assess upper extremity and 17 items to assess mobility. The estimated correlation between upper extremity and mobility was .59 using existing PROMIS physical functioning item parameters (r=.60 using parameters calibrated separately for upper-extremity and mobility items). Upper-extremity and mobility subdomains shared about 35% of the variance in common, and produced comparable scores whether calibrated separately or together. The identification of the subset of items tapping these 2 aspects of physical functioning and scored using the existing PROMIS parameters provides the option of scoring these subdomains in addition to the overall physical functioning score. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

R2R--software to speed the depiction of aesthetic consensus RNA secondary structures.

PubMed

Weinberg, Zasha; Breaker, Ronald R

2011-01-04

With continuing identification of novel structured noncoding RNAs, there is an increasing need to create schematic diagrams showing the consensus features of these molecules. RNA structural diagrams are typically made either with general-purpose drawing programs like Adobe Illustrator, or with automated or interactive programs specific to RNA. Unfortunately, the use of applications like Illustrator is extremely time consuming, while existing RNA-specific programs produce figures that are useful, but usually not of the same aesthetic quality as those produced at great cost in Illustrator. Additionally, most existing RNA-specific applications are designed for drawing single RNA molecules, not consensus diagrams. We created R2R, a computer program that facilitates the generation of aesthetic and readable drawings of RNA consensus diagrams in a fraction of the time required with general-purpose drawing programs. Since the inference of a consensus RNA structure typically requires a multiple-sequence alignment, the R2R user annotates the alignment with commands directing the layout and annotation of the RNA. R2R creates SVG or PDF output that can be imported into Adobe Illustrator, Inkscape or CorelDRAW. R2R can be used to create consensus sequence and secondary structure models for novel RNA structures or to revise models when new representatives for known RNA classes become available. Although R2R does not currently have a graphical user interface, it has proven useful in our efforts to create 100 schematic models of distinct noncoding RNA classes. R2R makes it possible to obtain high-quality drawings of the consensus sequence and structural models of many diverse RNA structures with a more practical amount of effort. R2R software is available at http://breaker.research.yale.edu/R2R and as an Additional file.

Organ models in wound ballistics: experimental study.

PubMed

Ozer, Mustafa Tahir; Oğünç, Gökhan; Eryilmaz, Mehmet; Yiğit, Taner; Menteş, Mustafa Oner; Dakak, Mehmet; Uzar, Ali Ihsan; Oner, Köksal

2007-01-01

Effects of various types and diameters of guns and related treatment principles are different. Our study was performed to experimentally demonstrate the effects of different gunshots in body tissues. 9x19 mm hand-gun and 7.62x51 mm G-3 infantry rifle were used in the study. Injury models were created through hand-gun and rifle shootings at isolated soft tissue, lower extremity, liver and intestine tissue simulants made of ballistic candle. High-speed cameras were used to capture 1000 frames per second. Images were examined and wound mechanisms were evaluated. It was observed that the colon content distributed more within the surrounding tissues by the rifle shootings comparing with hand-gun shootings and could be an infection source due to the large size of the cavity in the colon. Especially when the bullets hitting the bone were investigated, it was seen that much more tissue injury occurs with high speed bullets due to bullet deformation and fragmentation. However, no significant difference was found between the effect of hand-gun and rifle bullets passing through the extremity without hitting the bone. To know the type of the gun that caused the injury and its characteristics will allow to estimate severity and size of the injury before the treatment and to focus on different alternatives of treatment. Therefore, use of appropriate models is required in experimental studies.

Satellite-based Monitoring of global Precipitation using the PERSIANN system: from Weather- to Climate-scales with some application examples

NASA Astrophysics Data System (ADS)

Switzer, A.; Yap, W.; Lauro, F.; Gouramanis, C.; Dominey-Howes, D.; Labbate, M.

2016-12-01

This presentation provides an overview of the PERSIANN precipitation products from the near real time high-resolution (4km, 30 min) PERSIANN-CCS to the most recent 34+-year PERSIANN-CDR (25km, daily). It is widely believed that the hydrologic cycle has been intensifying due to global warming and the frequency and the intensity of hydrologic extremes has also been increasing. Using the long-term historical global high resolution (daily, 0.25 degree) PERSIANN-CDR dataset covering over three decades from 1983 to the present day, we assess changes in global precipitation across different spatial scales. Our results show differences in trends, depending on which spatial scale is used, highlighting the importance of spatial scale in trend analysis. In addition, while there is an easily observable increasing global temperature trend, the global precipitation trend results created by the PERSIANN-CDR dataset used in this study are inconclusive. In addition, we use PERSIANN-CDR to assess the performance of the 32 CMIP5 models in terms of extreme precipitation indices in various continent-climate zones. The assessment can provide a guide for both model developers to target regions and processes that are not yet fully captured in certain climate types, and for climate model output users to be able to select the models and/or the study areas that may best fit their applications of interest.

Satellite-based Monitoring of global Precipitation using the PERSIANN system: from Weather- to Climate-scales with some application examples

NASA Astrophysics Data System (ADS)

Sorooshian, S.; Nguyen, P.; Hsu, K. L.

2017-12-01

This presentation provides an overview of the PERSIANN precipitation products from the near real time high-resolution (4km, 30 min) PERSIANN-CCS to the most recent 34+-year PERSIANN-CDR (25km, daily). It is widely believed that the hydrologic cycle has been intensifying due to global warming and the frequency and the intensity of hydrologic extremes has also been increasing. Using the long-term historical global high resolution (daily, 0.25 degree) PERSIANN-CDR dataset covering over three decades from 1983 to the present day, we assess changes in global precipitation across different spatial scales. Our results show differences in trends, depending on which spatial scale is used, highlighting the importance of spatial scale in trend analysis. In addition, while there is an easily observable increasing global temperature trend, the global precipitation trend results created by the PERSIANN-CDR dataset used in this study are inconclusive. In addition, we use PERSIANN-CDR to assess the performance of the 32 CMIP5 models in terms of extreme precipitation indices in various continent-climate zones. The assessment can provide a guide for both model developers to target regions and processes that are not yet fully captured in certain climate types, and for climate model output users to be able to select the models and/or the study areas that may best fit their applications of interest.

Lessons learned in the analysis of high-dimensional data in vaccinomics

PubMed Central

Oberg, Ann L.; McKinney, Brett A.; Schaid, Daniel J.; Pankratz, V. Shane; Kennedy, Richard B.; Poland, Gregory A.

2015-01-01

The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine candidates. However, the application of systems biology to what has been termed “big data,” or “high-dimensional data,” is not without significant challenges—chief among them a paucity of gold standard analysis and modeling paradigms with which to interpret the data. In this article, we relate some of the lessons we have learned over the last decade of working with high-dimensional, high-throughput data as applied to the field of vaccinomics. The value of such efforts, however, is ultimately to better understand the immune mechanisms by which protective and non-protective responses to vaccines are generated, and to use this information to support a personalized vaccinology approach in creating better, and safer, vaccines for the public health. PMID:25957070

Lessons learned in the analysis of high-dimensional data in vaccinomics.

PubMed

Oberg, Ann L; McKinney, Brett A; Schaid, Daniel J; Pankratz, V Shane; Kennedy, Richard B; Poland, Gregory A

2015-09-29

The field of vaccinology is increasingly moving toward the generation, analysis, and modeling of extremely large and complex high-dimensional datasets. We have used data such as these in the development and advancement of the field of vaccinomics to enable prediction of vaccine responses and to develop new vaccine candidates. However, the application of systems biology to what has been termed "big data," or "high-dimensional data," is not without significant challenges-chief among them a paucity of gold standard analysis and modeling paradigms with which to interpret the data. In this article, we relate some of the lessons we have learned over the last decade of working with high-dimensional, high-throughput data as applied to the field of vaccinomics. The value of such efforts, however, is ultimately to better understand the immune mechanisms by which protective and non-protective responses to vaccines are generated, and to use this information to support a personalized vaccinology approach in creating better, and safer, vaccines for the public health. Copyright © 2015 Elsevier Ltd. All rights reserved.

Dissipation of ‘dark energy’ by cortex in knowledge retrieval

NASA Astrophysics Data System (ADS)

Capolupo, Antonio; Freeman, Walter J.; Vitiello, Giuseppe

2013-03-01

We have devised a thermodynamic model of cortical neurodynamics expressed at the classical level by neural networks and at the quantum level by dissipative quantum field theory. Our model is based on features in the spatial images of cortical activity newly revealed by high-density electrode arrays. We have incorporated the mechanism and necessity for so-called dark energy in knowledge retrieval. We have extended the model first using the Carnot cycle to define our measures for energy, entropy and temperature, and then using the Rankine cycle to incorporate criticality and phase transitions. We describe the dynamics of two interactive fields of neural activity that express knowledge, one at high and the other at low energy density, and the two operators that create and annihilate the fields. We postulate that the extremely high density of energy sequestered briefly in cortical activity patterns can account for the vividness, richness of associations, and emotional intensity of memories recalled by stimuli.

Dissipation of 'dark energy' by cortex in knowledge retrieval.

PubMed

Capolupo, Antonio; Freeman, Walter J; Vitiello, Giuseppe

2013-03-01

We have devised a thermodynamic model of cortical neurodynamics expressed at the classical level by neural networks and at the quantum level by dissipative quantum field theory. Our model is based on features in the spatial images of cortical activity newly revealed by high-density electrode arrays. We have incorporated the mechanism and necessity for so-called dark energy in knowledge retrieval. We have extended the model first using the Carnot cycle to define our measures for energy, entropy and temperature, and then using the Rankine cycle to incorporate criticality and phase transitions. We describe the dynamics of two interactive fields of neural activity that express knowledge, one at high and the other at low energy density, and the two operators that create and annihilate the fields. We postulate that the extremely high density of energy sequestered briefly in cortical activity patterns can account for the vividness, richness of associations, and emotional intensity of memories recalled by stimuli. Copyright © 2013 Elsevier B.V. All rights reserved.

Low-pressure electrical discharge experiment to simulate high-altitude lightning above thunderclouds

NASA Technical Reports Server (NTRS)

Jarzembski, M. A.; Srivastava, V.

1995-01-01

Recently, extremely interesting high-altitude cloud-ionosphere electrical discharges, like lightning above thunderstorms, have been observed from NASA's space shuttle missions and during airborne and ground-based experiments. To understand these discharges, a new experiment was conceived to simulate a thundercloud in a vacuum chamber using a dielectric in particulate form into which electrodes were inserted to create charge centers analogous to those in an electrified cloud. To represent the ionosphere, a conducting medium (metallic plate) was introduced at the top of the chamber. It was found that for different pressures between approximately 1 and 300 mb, corresponding to various upper atmospheric altitudes, different discharges occurred above the simulated thundercloud, and these bore a remarkable similarity to the observed atmospheric phenomena. At pressures greater than 300 mb, these discharges were rare and only discharges within the simulated thundercloud were observed. Use of a particulate dielectric was critical for the successful simulation of the high-altitude lightning.

Plasma-Facing Component and Materials Testing for the NSTX-U

NASA Astrophysics Data System (ADS)

Jaworski, Michael; Brooks, A.; Gerhardt, S.; Loesser, D.; Mardenfeld, M.; Menard, J.; Gray, T.; Reinke, M.

2017-10-01

The NSTX-U Recovery Project is developing plasma-facing components for use in the divertor of NSTX-U. The extreme conditions of the NSTX-U divertor make it possible to stress even graphite surfaces to the material limits leading to the possibility of component failures. In addition, the complex, mixed-material environment of the NSTX-U due to the use of boron and lithium wall conditioning techniques creates significant uncertainties in the monitoring of the PFCs. A testing program has been developed to inform on the material and design limitations of the NSTX-U high-heat flux components. These tests include high-heat flux testing in electron beam facilities as well as plasma-based testing. The NSTX-U components could experience perpendicular heat fluxes as high as 45 MW/m2. Parallel heat fluxes onto leading edges could reach 475 MW/m2. The testing program and material survey plan will be presented. Work supported by DOE contract DE-AC02-09CH11466 and DE-AC05-00OR22725.

Method of achieving the controlled release of thermonuclear energy

DOEpatents

Brueckner, Keith A.

1986-01-01

A method of achieving the controlled release of thermonuclear energy by illuminating a minute, solid density, hollow shell of a mixture of material such as deuterium and tritium with a high intensity, uniformly converging laser wave to effect an extremely rapid build-up of energy in inwardly traveling shock waves to implode the shell creating thermonuclear conditions causing a reaction of deuterons and tritons and a resultant high energy thermonuclear burn. Utilizing the resulting energy as a thermal source and to breed tritium or plutonium. The invention also contemplates a laser source wherein the flux level is increased with time to reduce the initial shock heating of fuel and provide maximum compression after implosion; and, in addition, computations and an equation are provided to enable the selection of a design having a high degree of stability and a dependable fusion performance by establishing a proper relationship between the laser energy input and the size and character of the selected material for the fusion capsule.

Anomalies detected in Central European Temperature series reconstructed from documentary evidence and instrumental records for the last 500 years

NASA Astrophysics Data System (ADS)

Dobrovolný, P.; Brázdil, R.; Moberg, A.; Wilson, R.

2009-09-01

Various types of documentary evidence from Germany, Switzerland and the Czech Republic have been used to create temperature indices for the period 1500-1854. Homogenized temperature series from 11 Central European stations covering the period 1760-2007 served as target values to reconstruct monthly, seasonal and annual temperatures in Central Europe since AD 1500. Spatial coherency of the compiled Central European Temperature (CEuT) series is presented. The CEuT series is further used to define extremely cold/warm months and seasons and the spatial and temporal distribution of such extremes are presented in context of existing knowledge of climate variability within Europe. The CEuT extremes are compared to corresponding documentary based chronologies from other European countries or regions as well as reconstructions from other proxies (e.g. tree rings). The most pronounced cold/warm seasons are analyzed with respect to potential causes and also with respect to recent warming trends. We discuss the potential of documentary evidence to study weather and climate extremes and show that such data provide valuable information for studying past human response to climatic extremes.

Regional climate assessment of precipitation and temperature in Southern Punjab (Pakistan) using SimCLIM climate model for different temporal scales

NASA Astrophysics Data System (ADS)

Amin, Asad; Nasim, Wajid; Mubeen, Muhammad; Sarwar, Saleem; Urich, Peter; Ahmad, Ashfaq; Wajid, Aftab; Khaliq, Tasneem; Rasul, Fahd; Hammad, Hafiz Mohkum; Rehmani, Muhammad Ishaq Asif; Mubarak, Hussani; Mirza, Nosheen; Wahid, Abdul; Ahamd, Shakeel; Fahad, Shah; Ullah, Abid; Khan, Mohammad Nauman; Ameen, Asif; Amanullah; Shahzad, Babar; Saud, Shah; Alharby, Hesham; Ata-Ul-Karim, Syed Tahir; Adnan, Muhammad; Islam, Faisal; Ali, Qazi Shoaib

2018-01-01

Unbalanced climate during the last decades has created spatially alarming and destructive situations in the world. Anomalies in temperature and precipitation enhance the risks for crop production in large agricultural region (especially the Southern Punjab) of Pakistan. Detailed analysis of historic weather data (1980-2011) record helped in creating baseline data to compare with model projection (SimCLIM) for regional level. Ensemble of 40 GCMs used for climatic projections with greenhouse gas (GHG) representative concentration pathways (RCP-4.5, 6.0, 8.5) was selected on the baseline comparison and used for 2025 and 2050 climate projection. Precipitation projected by ensemble and regional weather observatory at baseline showed highly unpredictable nature while both temperature extremes showed 95 % confidence level on a monthly projection. Percentage change in precipitation projected by model with RCP-4.5, RCP-6.0, and RCP-8.5 showed uncertainty 3.3 to 5.6 %, 2.9 to 5.2 %, and 3.6 to 7.9 % for 2025 and 2050, respectively. Percentage change of minimum temperature from base temperature showed that 5.1, 4.7, and 5.8 % for 2025 and 9.0, 8.1, and 12.0 % increase for projection year 2050 with RCP-4.5, 6.0, and 8.5 and maximum temperature 2.7, 2.5, and 3.0 % for 2025 and 4.7, 4.4, and 6.4 % for 2050 will be increased with RCP-4.5, 6.0, and 8.5, respectively. Uneven increase in precipitation and asymmetric increase in temperature extremes in future would also increase the risk associated with management of climatic uncertainties. Future climate projection will enable us for better risk management decisions.

Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH-JAPAN study.

PubMed

Hirata, Aya; Sugiyama, Daisuke; Watanabe, Makoto; Tamakoshi, Akiko; Iso, Hiroyasu; Kotani, Kazuhiko; Kiyama, Masahiko; Yamada, Michiko; Ishikawa, Shizukiyo; Murakami, Yoshitaka; Miura, Katsuyuki; Ueshima, Hirotsugu; Okamura, Tomonori

2018-02-08

The effect of very high or extremely high levels of high-density lipoprotein cholesterol (HDL-C) on cardiovascular disease (CVD) is not well described. Although a few recent studies have reported the adverse effects of extremely high levels of HDL-C on CVD events, these did not show a statistically significant association between extremely high levels of HDL-C and cause-specific CVD mortality. In addition, Asian populations have not been studied. We examine the impact of extremely high levels of HDL-C on cause-specific CVD mortality using pooled data of Japanese cohort studies. We performed a large-scale pooled analysis of 9 Japanese cohorts including 43,407 participants aged 40-89 years, dividing the participants into 5 groups by HDL-C levels, including extremely high levels of HDL-C ≥2.33 mmol/L (≥90 mg/dL). We estimated the adjusted hazard ratio of each HDL-C category for all-cause death and cause-specific deaths compared with HDL-C 1.04-1.55 mmol/L (40-59 mg/dL) using a cohort-stratified Cox proportional hazards model. During a 12.1-year follow-up, 4995 all-cause deaths and 1280 deaths due to overall CVD were identified. Extremely high levels of HDL-C were significantly associated with increased risk of atherosclerotic CVD mortality (hazard ratio = 2.37, 95% confidence interval: 1.37-4.09 for total) and increased risk for coronary heart disease and ischemic stroke. In addition, the risk for extremely high HDL-C was more evident among current drinkers. We showed extremely high levels of HDL-C had an adverse effect on atherosclerotic CVD mortality in a pooled analysis of Japanese cohorts. Copyright © 2018 National Lipid Association. Published by Elsevier Inc. All rights reserved.

A Unified Data-Driven Approach for Programming In Situ Analysis and Visualization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aiken, Alex

The placement and movement of data is becoming the key limiting factor on both performance and energy efficiency of high performance computations. As systems generate more data, it is becoming increasingly difficult to actually move that data elsewhere for post-processing, as the rate of improvements in supporting I/O infrastructure is not keeping pace. Together, these trends are creating a shift in how we think about exascale computations, from a viewpoint that focuses on FLOPS to one that focuses on data and data-centric operations as fundamental to the reasoning about, and optimization of, scientific workflows on extreme-scale architectures. The overarching goalmore » of our effort was the study of a unified data-driven approach for programming applications and in situ analysis and visualization. Our work was to understand the interplay between data-centric programming model requirements at extreme-scale and the overall impact of those requirements on the design, capabilities, flexibility, and implementation details for both applications and the supporting in situ infrastructure. In this context, we made many improvements to the Legion programming system (one of the leading data-centric models today) and demonstrated in situ analyses on real application codes using these improvements.« less

Isosurface Extraction in Time-Varying Fields Using a Temporal Hierarchical Index Tree

NASA Technical Reports Server (NTRS)

Shen, Han-Wei; Gerald-Yamasaki, Michael (Technical Monitor)

1998-01-01

Many high-performance isosurface extraction algorithms have been proposed in the past several years as a result of intensive research efforts. When applying these algorithms to large-scale time-varying fields, the storage overhead incurred from storing the search index often becomes overwhelming. this paper proposes an algorithm for locating isosurface cells in time-varying fields. We devise a new data structure, called Temporal Hierarchical Index Tree, which utilizes the temporal coherence that exists in a time-varying field and adoptively coalesces the cells' extreme values over time; the resulting extreme values are then used to create the isosurface cell search index. For a typical time-varying scalar data set, not only does this temporal hierarchical index tree require much less storage space, but also the amount of I/O required to access the indices from the disk at different time steps is substantially reduced. We illustrate the utility and speed of our algorithm with data from several large-scale time-varying CID simulations. Our algorithm can achieve more than 80% of disk-space savings when compared with the existing techniques, while the isosurface extraction time is nearly optimal.

Silent Aircraft Initiative Concept Risk Assessment

NASA Technical Reports Server (NTRS)

Nickol, Craig L.

2008-01-01

A risk assessment of the Silent Aircraft Initiative's SAX-40 concept design for extremely low noise has been performed. A NASA team developed a list of 27 risk items, and evaluated the level of risk for each item in terms of the likelihood that the risk would occur and the consequences of the occurrence. The following risk items were identified as high risk, meaning that the combination of likelihood and consequence put them into the top one-fourth of the risk matrix: structures and weight prediction; boundary-layer ingestion (BLI) and inlet design; variable-area exhaust and thrust vectoring; displaced-threshold and continuous descent approach (CDA) operational concepts; cost; human factors; and overall noise performance. Several advanced-technology baseline concepts were created to serve as a basis for comparison to the SAX-40 concept. These comparisons indicate that the SAX-40 would have significantly greater research, development, test, and engineering (RDT&E) and production costs than a conventional aircraft with similar technology levels. Therefore, the cost of obtaining the extremely low noise capability that has been estimated for the SAX-40 is significant. The SAX-40 concept design proved successful in focusing attention toward low noise technologies and in raising public awareness of the issue.

Current Concepts in Examination and Treatment of Elbow Tendon Injury

PubMed Central

Ellenbecker, Todd S.; Nirschl, Robert; Renstrom, Per

2013-01-01

Context: Injuries to the tendons of the elbow occur frequently in the overhead athlete, creating a significant loss of function and dilemma to sports medicine professionals. A detailed review of the anatomy, etiology, and pathophysiology of tendon injury coupled with comprehensive evaluation and treatment information is needed for clinicians to optimally design treatment programs for rehabilitation and prevention. Evidence Acquisitions: The PubMed database was searched in January 2012 for English-language articles pertaining to elbow tendon injury. Results: Detailed information on tendon pathophysiology was found along with incidence of elbow injury in overhead athletes. Several evidence-based reviews were identified, providing a thorough review of the recommended rehabilitation for elbow tendon injury. Conclusions: Humeral epicondylitis is an extra-articular tendon injury that is common in athletes subjected to repetitive upper extremity loading. Research is limited on the identification of treatment modalities that can reduce pain and restore function to the elbow. Eccentric exercise has been studied in several investigations and, when coupled with a complete upper extremity strengthening program, can produce positive results in patients with elbow tendon injury. Further research is needed in high-level study to delineate optimal treatment methods. PMID:24427389

Laser machining of explosives

DOEpatents

Perry, Michael D.; Stuart, Brent C.; Banks, Paul S.; Myers, Booth R.; Sefcik, Joseph A.

2000-01-01

The invention consists of a method for machining (cutting, drilling, sculpting) of explosives (e.g., TNT, TATB, PETN, RDX, etc.). By using pulses of a duration in the range of 5 femtoseconds to 50 picoseconds, extremely precise and rapid machining can be achieved with essentially no heat or shock affected zone. In this method, material is removed by a nonthermal mechanism. A combination of multiphoton and collisional ionization creates a critical density plasma in a time scale much shorter than electron kinetic energy is transferred to the lattice. The resulting plasma is far from thermal equilibrium. The material is in essence converted from its initial solid-state directly into a fully ionized plasma on a time scale too short for thermal equilibrium to be established with the lattice. As a result, there is negligible heat conduction beyond the region removed resulting in negligible thermal stress or shock to the material beyond a few microns from the laser machined surface. Hydrodynamic expansion of the plasma eliminates the need for any ancillary techniques to remove material and produces extremely high quality machined surfaces. There is no detonation or deflagration of the explosive in the process and the material which is removed is rendered inert.

RXTE Observation of Cygnus X-1: III. Implications for Compton Corona and ADAF Models. Report 3; Implications for Compton Corona and ADAF Models

NASA Technical Reports Server (NTRS)

Nowak, Michael A.; Wilms, Joern; Vaughan, Brian A.; Dove, James B.; Begelman, Mitchell C.

1999-01-01

We have recently shown that a 'sphere + disk' geometry Compton corona model provides a good description of Rossi X-ray Timing Explorer (RXTE) observations of the hard/low state of Cygnus X-1. Separately, we have analyzed the temporal data provided by RXTE. In this paper we consider the implications of this timing analysis for our best-fit 'sphere + disk' Comptonization models. We focus our attention on the observed Fourier frequency-dependent time delays between hard and soft photons. We consider whether the observed time delays are: created in the disk but are merely reprocessed by the corona; created by differences between the hard and soft photon diffusion times in coronae with extremely large radii; or are due to 'propagation' of disturbances through the corona. We find that the time delays are most likely created directly within the corona; however, it is currently uncertain which specific model is the most likely explanation. Models that posit a large coronal radius [or equivalently, a large Advection Dominated Accretion Flow (ADAF) region] do not fully address all the details of the observed spectrum. The Compton corona models that do address the full spectrum do not contain dynamical information. We show, however, that simple phenomenological propagation models for the observed time delays for these latter models imply extremely slow characteristic propagation speeds within the coronal region.

Pulsars and Extreme Physics

NASA Astrophysics Data System (ADS)

Bell-Burnell, Jocelyn

2004-10-01

Pulsars were discovered 35 years ago. What do we know about them now, and what have they taught us about the extremes of physics? With an average density comparable to that of the nucleus, magnetic fields around 108 T and speeds close to c these objects have stretched our understanding of the behaviour of matter. They serve as extrememly accurate clocks with which to carry out precision experiments in relativity. Created in cataclysmic explosions, pulsars are a (stellar) form of life after death. After half a billion revolutions most pulsars finally die, but amazingly some are born again to yet another, even weirder, afterlife. Pulsar research continues lively, delivering exciting, startling and almost unbelievable results!

The propaganda of extreme hostility: denunciation and the regulation of the group.

PubMed

Finlay, W M L

2007-06-01

This paper discusses how those espousing racist or separatist ideologies seek to persuade others to conform to their beliefs. Using examples from Nazi Germany, White Power movements in the USA and the extreme fringes of Zionist politics, it illustrates how notions of identity are linked to positions of hostility, hatred or separatism from other groups. In particular, it describes how those who maintain relations with other groups or who oppose hostility are discounted through accounts of social influence. The effectiveness of this rhetoric in terms of creating climates of social and self-censure, and of silencing dissent in situations of conflict, is discussed.

Islamist Extremism in Bangladesh

DTIC Science & Technology

2007-01-31

political stability may create additional space within which Islamist militants may be increasingly free to operate. Such a development may have destabilizing implications for Bangladesh, South Asia, and the Islamic world. They also have the potential to undermine U.S. interests. See CRS Report RL33646, Bangladesh: Background and U.S. Relations, by Bruce Vaughn, for additional

Blind Ambition

ERIC Educational Resources Information Center

Olson, Catherine Applefeld

2009-01-01

No matter how dedicated they may be, some teachers are daunted by extreme challenges. Carol Agler, music director at the Ohio State School for the Blind (OSSB), is not one of those teachers. Since joining the OSSB staff 11 years ago, Agler has revived the school's long-dormant band program and created its first marching band. Next January, she…

Fund Accounting Is Dead: Let This Complex System Rest in Peace.

ERIC Educational Resources Information Center

Coville, Joanne

1995-01-01

It is argued that colleges and universities have created extremely complex and convoluted accounting/reporting systems using fund accounting. Recent changes in accounting standards should be seen as an opportunity to streamline many of the processes that have been designed to support funds, allowing introduction of other approaches. (MSE)

Mathematical String Sculptures: A Case Study in Computationally-Enhanced Mathematical Crafts

ERIC Educational Resources Information Center

Eisenberg, Michael

2007-01-01

Mathematical string sculptures constitute an extremely beautiful realm of mathematical crafts. This snapshot begins with a description of a marvelous (and no longer manufactured) toy called Space Spider, which provided a framework with which children could experiment with string sculptures. Using a computer-controlled laser cutter to create frames…

Social Network Analysis in E-Learning Environments: A Preliminary Systematic Review

ERIC Educational Resources Information Center

Cela, Karina L.; Sicilia, Miguel Ángel; Sánchez, Salvador

2015-01-01

E-learning occupies an increasingly prominent place in education. It provides the learner with a rich virtual network where he or she can exchange ideas and information and create synergies through interactions with other members of the network, whether fellow learners or teachers. Social network analysis (SNA) has proven extremely powerful at…

Age-of-Acquisition Effects in Visual Word Recognition: Evidence from Expert Vocabularies

ERIC Educational Resources Information Center

Stadthagen-Gonzalez, Hans; Bowers, Jeffrey S.; Damian, Markus F.

2004-01-01

Three experiments assessed the contributions of age-of-acquisition (AoA) and frequency to visual word recognition. Three databases were created from electronic journals in chemistry, psychology and geology in order to identify technical words that are extremely frequent in each discipline but acquired late in life. In Experiment 1, psychologists…

Using Humor in Physical Education

ERIC Educational Resources Information Center

Barney, David; Christenson, Robert

2013-01-01

Humor can be extremely beneficial in everyday life, whether giving or receiving it. It can be used to lighten the mood, give encouragement, or make corrections. Humor in physical education is no exception. Physical educators can use humor as a teaching tool and to create an environment for students to acquire the knowledge to practice a lifetime…

Interrupting Extremism by Creating Educative Turbulence

ERIC Educational Resources Information Center

Davies, Lynn

2014-01-01

This article begins from the premise that it is important to explore how people unlearn, as well as learn, specifically in terms of extremist or violent attitudes. It shows the implications of two aspects of complexity theory--turbulence and self-organisation--for educational practice and the fostering of a complex adaptive school, which can aid…

Cooperative Efforts in Fuels Management

Treesearch

Gerald L. Adams

1995-01-01

Our forests have been neglected or protected to death, creating an extreme wildfire risk in wildland urban intermix communities. We as agencies and organizations are just now beginning to understand that the fuel problems we have across the western states are not a single agency problem, but "our problem." Wildfires do not respect boundaries, be they...

One-shot Synesthesia

PubMed Central

Kirschner, Alexandra; Nikolić, Danko

2017-01-01

Abstract Synesthesia is commonly thought to be a phenomenon of fixed associations between an outside inducer and a vivid concurrent experience. Hence, it has been proposed that synesthesia occurs due to additional connections in the brain with which synesthetes are born. Here we show that synesthesia can be a much richer and more flexible phenomenon with a capability to creatively construct novel synesthetic experiences as events unfold in people’s lives. We describe here cases of synesthetes who occasionally generate novel synesthetic experience, called one-shot synesthesias. These synesthetic experiences seem to share all the properties with the classical synesthetic associations except that they occur extremely rarely, people recalling only a few events over the lifetime. It appears that these one-shots are not created at random but are instead responses to specific life events. We contrast the properties of those rare synesthetic events with other, more commonly known forms of synesthesia that also create novel synesthetic experiences, but at a high rate—sometimes creating novel experiences every few seconds. We argue that one-shot synesthesias indicate that synesthetic associations are by their nature not prewired at birth but are dynamically constructed through mental operations and according to the needs of a synesthetic mind. Our conclusions have implications for understanding the biological underpinnings of synesthesia and the role the phenomenon plays in the lives of people endowed with synesthetic capacities. PMID:29188078

Extreme Value Analysis of hydro meteorological extremes in the ClimEx Large-Ensemble

NASA Astrophysics Data System (ADS)

Wood, R. R.; Martel, J. L.; Willkofer, F.; von Trentini, F.; Schmid, F. J.; Leduc, M.; Frigon, A.; Ludwig, R.

2017-12-01

Many studies show an increase in the magnitude and frequency of hydrological extreme events in the course of climate change. However the contribution of natural variability to the magnitude and frequency of hydrological extreme events is not yet settled. A reliable estimate of extreme events is from great interest for water management and public safety. In the course of the ClimEx Project (www.climex-project.org) a new single-model large-ensemble was created by dynamically downscaling the CanESM2 large-ensemble with the Canadian Regional Climate Model version 5 (CRCM5) for an European Domain and a Northeastern North-American domain. By utilizing the ClimEx 50-Member Large-Ensemble (CRCM5 driven by CanESM2 Large-Ensemble) a thorough analysis of natural variability in extreme events is possible. Are the current extreme value statistical methods able to account for natural variability? How large is the natural variability for e.g. a 1/100 year return period derived from a 50-Member Large-Ensemble for Europe and Northeastern North-America? These questions should be answered by applying various generalized extreme value distributions (GEV) to the ClimEx Large-Ensemble. Hereby various return levels (5-, 10-, 20-, 30-, 60- and 100-years) based on various lengths of time series (20-, 30-, 50-, 100- and 1500-years) should be analyzed for the maximum one day precipitation (RX1d), the maximum three hourly precipitation (RX3h) and the streamflow for selected catchments in Europe. The long time series of the ClimEx Ensemble (7500 years) allows us to give a first reliable estimate of the magnitude and frequency of certain extreme events.

A 500 year climate reconstruction of Southwest Germany based on documentary and direct data with a special focus on high resolute reconstructed extreme rain events

NASA Astrophysics Data System (ADS)

Dostal, P.; Seidel, J.; Imbery, F.

2010-09-01

A 500 year climate reconstruction of Southwest Germany based on documentary and direct data with a special focus on high resolute reconstructed extreme rain events Against the background of an increasing world population and the changes that this is causing to the earth, the increasing industrialisation resulting in more emissions of greenhouse gases, it is indispensable to differentiate between natural and anthropogenic climate changes. This applies equally to global as well as regional climates. Due to the fact, that the weather data measurement series in the upper Rhine valley go back a maximum of 150 years, it is not possible to use this data to grasp long term climate fluctuations. For example, the current climate is integrated in long scale climate cycles which last thousands of years. To describe these changes accurately, it is necessary to reconstruct the climate beyond that of instrumental series measurements. With the application of direct and indirect data (proxy data) a climate reconstruction will be attempted for the area of region TriRhena. With the application of documentary data it is possible to reconstruct the climate prior to instrumental measurements. These historical records are made up of, for e.g. weather descriptions, information about the wine harvest and other agricultural products, as well as their price fluctuations. Using this data it is possible to calculate meteorological parameters creating an index of air temperature and precipitation values. Climate is an integration of weather and therefore its worth to set the focus also on single interesting weather events. Especially extreme events can contribute to the thesis "learning from the past for a better future". Aim of the research is to identify and apply extreme flood events of the past 500 years as a basis for further analysis like a contribution to improve current flood hazard maps. The data which will be presented were extracted from historical records such as local annuals and chronologies from 1500-1900 and supplemented by instrumental observations since 1755.

Three-dimensional reconstruction of the topographical cerebral surface anatomy for presurgical planning with free OsiriX Software.

PubMed

Harput, Mehmet V; Gonzalez-Lopez, Pablo; Türe, Uğur

2014-09-01

During surgery for intrinsic brain lesions, it is important to distinguish the pathological gyrus from the surrounding normal sulci and gyri. This task is usually tedious because of the pia-arachnoid membranes with their arterial and venous complexes that obscure the underlying anatomy. Moreover, most tumors grow in the white matter without initially distorting the cortical anatomy, making their direct visualization more difficult. To create and evaluate a simple and free surgical planning tool to simulate the anatomy of the surgical field with and without vessels. We used free computer software (OsiriX Medical Imaging Software) that allowed us to create 3-dimensional reconstructions of the cerebral surface with and without cortical vessels. These reconstructions made use of magnetic resonance images from 51 patients with neocortical supratentorial lesions operated on over a period of 21 months (June 2011 to February 2013). The 3-dimensional (3-D) anatomic images were compared with the true surgical view to evaluate their accuracy. In all patients, the landmarks determined by 3-D reconstruction were cross-checked during surgery with high-resolution ultrasonography; in select cases, they were also checked with indocyanine green videoangiography. The reconstructed neurovascular structures were confirmed intraoperatively in all patients. We found this technique to be extremely useful in achieving pure lesionectomy, as it defines tumor's borders precisely. A 3-D reconstruction of the cortical surface can be easily created with free OsiriX software. This technique helps the surgeon perfect the mentally created 3-D picture of the tumor location to carry out cleaner, safer surgeries.

The effect of ankle bracing on lower extremity biomechanics during landing: A systematic review.

PubMed

Mason-Mackay, A R; Whatman, C; Reid, D

2016-07-01

To examine the evidence for effect of ankle bracing on lower-extremity landing biomechanics. Literature review. Systematic search of the literature on EBSCO health databases. Articles critiqued by two reviewers. Ten studies were identified which investigated the effect of ankle bracing on landing biomechanics. Overall results suggest that landing biomechanics are altered with some brace types but studies disagree as to the particular variables affected. There is evidence that ankle bracing may alter lower-extremity landing biomechanics in a manner which predisposes athletes to injury. The focus of studies on specific biomechanical variables rather than biomechanical patterns, analysis of pooled data means in the presence of differing landing styles between participants, variation in landing-tasks investigated in different studies, and lack of studies investigating goal-directed sport-specific landing tasks creates difficulty in interpreting results. These areas require further research. Copyright © 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Formation of enriched black tea extract loaded chitosan nanoparticles via electrospraying

NASA Astrophysics Data System (ADS)

Hammond, Samuel James

Creating nanoparticles of beneficial nutraceuticals and pharmaceuticals has had a large surge of research due to the enhancement of absorption and bioavailability by decreasing their size. One of these ways is by electrohydrodynamic atomization, also known as electrospraying. In general, this novel process is done by forcing a liquid through a capillary nozzle and which is subjected to an electrical field. While there are different ways to create nanoparticles, the novel method of electrospraying can be beneficial over other types of nanoparticle formation. Reasons include high control over particle size and distribution by altering electrospray parameters (voltage, flow rate, distance, and time), higher encapsulation efficiency than other methods, and also it is a one step process without exposure to extreme conditions (Gomez-Estaca et. al. 2012, Jaworek and Sobcyzk 2008). The current study aimed to create a chitosan encapsulated theaflavin-2 enriched black tea extract (BTE) nanoparticles via electrospraying. The first step of this process was to create the smallest chitosan nanoparticles possible by altering the electrospray parameters and the chitosan-acetic acid solution parameters. The solution properties altered include chitosan molecular weight, acetic acid concentration, and chitosan concentration. Specifically, the electrospray parameters such as voltage, flow rate and distance from syringe to collector are the most important in determining particle size. After creating the smallest chitosan particles, the TF-2 enriched black tea extract was added to the chitosan-acetic acid solution to be electrosprayed. The particles were assessed with the following procedures: Atomic force microscopy (AFM) and scanning electron microscopy (SEM) for particle morphology and size, and loading efficiency with ultraviolet--visible spectrophotometer (UV-VIS). Chitosan-BTE nanoparticles were successfully created in a one step process. Diameter of the particles on average ranged from 255 nm to 560 nm. Encapsulation efficiency was above 95% for all but one sample set. Future work includes MTT assay and cellular uptake.

Future changes in hydro-climatic extremes in the Upper Indus, Ganges, and Brahmaputra River basins

PubMed Central

Lutz, Arthur F.; Nepal, Santosh; Khanal, Sonu; Pradhananga, Saurav; Shrestha, Arun B.; Immerzeel, Walter W.

2017-01-01

Future hydrological extremes, such as floods and droughts, may pose serious threats for the livelihoods in the upstream domains of the Indus, Ganges, Brahmaputra. For this reason, the impacts of climate change on future hydrological extremes is investigated in these river basins. We use a fully-distributed cryospheric-hydrological model to simulate current and future hydrological fluxes and force the model with an ensemble of 8 downscaled General Circulation Models (GCMs) that are selected from the RCP4.5 and RCP8.5 scenarios. The model is calibrated on observed daily discharge and geodetic mass balances. The climate forcing and the outputs of the hydrological model are used to evaluate future changes in climatic extremes, and hydrological extremes by focusing on high and low flows. The outcomes show an increase in the magnitude of climatic means and extremes towards the end of the 21st century where climatic extremes tend to increase stronger than climatic means. Future mean discharge and high flow conditions will very likely increase. These increases might mainly be the result of increasing precipitation extremes. To some extent temperature extremes might also contribute to increasing discharge extremes, although this is highly dependent on magnitude of change in temperature extremes. Low flow conditions may occur less frequently, although the uncertainties in low flow projections can be high. The results of this study may contribute to improved understanding on the implications of climate change for the occurrence of future hydrological extremes in the Hindu Kush–Himalayan region. PMID:29287098

Probabilistic forecasting of extreme weather events based on extreme value theory

NASA Astrophysics Data System (ADS)

Van De Vyver, Hans; Van Schaeybroeck, Bert

2016-04-01

Extreme events in weather and climate such as high wind gusts, heavy precipitation or extreme temperatures are commonly associated with high impacts on both environment and society. Forecasting extreme weather events is difficult, and very high-resolution models are needed to describe explicitly extreme weather phenomena. A prediction system for such events should therefore preferably be probabilistic in nature. Probabilistic forecasts and state estimations are nowadays common in the numerical weather prediction community. In this work, we develop a new probabilistic framework based on extreme value theory that aims to provide early warnings up to several days in advance. We consider the combined events when an observation variable Y (for instance wind speed) exceeds a high threshold y and its corresponding deterministic forecasts X also exceeds a high forecast threshold y. More specifically two problems are addressed:} We consider pairs (X,Y) of extreme events where X represents a deterministic forecast, and Y the observation variable (for instance wind speed). More specifically two problems are addressed: Given a high forecast X=x_0, what is the probability that Y>y? In other words: provide inference on the conditional probability: [ Pr{Y>y|X=x_0}. ] Given a probabilistic model for Problem 1, what is the impact on the verification analysis of extreme events. These problems can be solved with bivariate extremes (Coles, 2001), and the verification analysis in (Ferro, 2007). We apply the Ramos and Ledford (2009) parametric model for bivariate tail estimation of the pair (X,Y). The model accommodates different types of extremal dependence and asymmetry within a parsimonious representation. Results are presented using the ensemble reforecast system of the European Centre of Weather Forecasts (Hagedorn, 2008). Coles, S. (2001) An Introduction to Statistical modelling of Extreme Values. Springer-Verlag.Ferro, C.A.T. (2007) A probability model for verifying deterministic forecasts of extreme events. Wea. Forecasting {22}, 1089-1100.Hagedorn, R. (2008) Using the ECMWF reforecast dataset to calibrate EPS forecasts. ECMWF Newsletter, {117}, 8-13.Ramos, A., Ledford, A. (2009) A new class of models for bivariate joint tails. J.R. Statist. Soc. B {71}, 219-241.

Remote Sensing Time Series Product Tool

NASA Technical Reports Server (NTRS)

Predos, Don; Ryan, Robert E.; Ross, Kenton W.

2006-01-01

The TSPT (Time Series Product Tool) software was custom-designed for NASA to rapidly create and display single-band and band-combination time series, such as NDVI (Normalized Difference Vegetation Index) images, for wide-area crop surveillance and for other time-critical applications. The TSPT, developed in MATLAB, allows users to create and display various MODIS (Moderate Resolution Imaging Spectroradiometer) or simulated VIIRS (Visible/Infrared Imager Radiometer Suite) products as single images, as time series plots at a selected location, or as temporally processed image videos. Manually creating these types of products is extremely labor intensive; however, the TSPT development tool makes the process simplified and efficient. MODIS is ideal for monitoring large crop areas because of its wide swath (2330 km), its relatively small ground sample distance (250 m), and its high temporal revisit time (twice daily). Furthermore, because MODIS imagery is acquired daily, rapid changes in vegetative health can potentially be detected. The new TSPT technology provides users with the ability to temporally process high-revisit-rate satellite imagery, such as that acquired from MODIS and from its successor, the VIIRS. The TSPT features the important capability of fusing data from both MODIS instruments onboard the Terra and Aqua satellites, which drastically improves cloud statistics. With the TSPT, MODIS metadata is used to find and optionally remove bad and suspect data. Noise removal and temporal processing techniques allow users to create low-noise time series plots and image videos and to select settings and thresholds that tailor particular output products. The TSPT GUI (graphical user interface) provides an interactive environment for crafting what-if scenarios by enabling a user to repeat product generation using different settings and thresholds. The TSPT Application Programming Interface provides more fine-tuned control of product generation, allowing experienced programmers to bypass the GUI and to create more user-specific output products, such as comparison time plots or images. This type of time series analysis tool for remotely sensed imagery could be the basis of a large-area vegetation surveillance system. The TSPT has been used to generate NDVI time series over growing seasons in California and Argentina and for hurricane events, such as Hurricane Katrina.

Modified Inverse First Order Reliability Method (I-FORM) for Predicting Extreme Sea States.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eckert-Gallup, Aubrey Celia; Sallaberry, Cedric Jean-Marie; Dallman, Ann Renee

Environmental contours describing extreme sea states are generated as the input for numerical or physical model simulation s as a part of the stand ard current practice for designing marine structure s to survive extreme sea states. Such environmental contours are characterized by combinations of significant wave height ( ) and energy period ( ) values calculated for a given recurrence interval using a set of data based on hindcast simulations or buoy observations over a sufficient period of record. The use of the inverse first - order reliability method (IFORM) i s standard design practice for generating environmental contours.more » In this paper, the traditional appli cation of the IFORM to generating environmental contours representing extreme sea states is described in detail and its merits and drawbacks are assessed. The application of additional methods for analyzing sea state data including the use of principal component analysis (PCA) to create an uncorrelated representation of the data under consideration is proposed. A reexamination of the components of the IFORM application to the problem at hand including the use of new distribution fitting techniques are shown to contribute to the development of more accurate a nd reasonable representations of extreme sea states for use in survivability analysis for marine struc tures. Keywords: In verse FORM, Principal Component Analysis , Environmental Contours, Extreme Sea State Characteri zation, Wave Energy Converters« less

Miniaturized, High-Speed, Modulated X-Ray Source

NASA Technical Reports Server (NTRS)

Gendreau, Keith; Arzoumanian, Zaven; Kenyon, Steve; Spartana, Nick

2013-01-01

A low-cost, miniature x-ray source has been developed that can be modulated in intensity from completely off to full intensity on nanosecond timescales. This modulated x-ray source (MXS) has no filaments and is extremely rugged. The energy level of the MXS is adjustable from 0 to more than 100 keV. It can be used as the core of many new devices, providing the first practical, arbitrarily time-variable source of x-rays. The high-speed switching capability and miniature size make possible many new technologies including x-ray-based communication, compact time-resolved x-ray diffraction, novel x-ray fluorescence instruments, and low- and precise-dose medical x-rays. To make x-rays, the usual method is to accelerate electrons into a target material held at a high potential. When the electrons stop in the target, x-rays are produced with a spectrum that is a function of the target material and the energy to which the electrons are accelerated. Most commonly, the electrons come from a hot filament. In the MXS, the electrons start off as optically driven photoelectrons. The modulation of the x-rays is then tied to the modulation of the light that drives the photoelectron source. Much of the recent development has consisted of creating a photoelectrically-driven electron source that is robust, low in cost, and offers high intensity. For robustness, metal photocathodes were adopted, including aluminum and magnesium. Ultraviolet light from 255- to 350-nm LEDs (light emitting diodes) stimulated the photoemissions from these photocathodes with an efficiency that is maximized at the low-wavelength end (255 nm) to a value of roughly 10(exp -4). The MXS units now have much higher brightness, are much smaller, and are made using a number of commercially available components, making them extremely inexpensive. In the latest MXS design, UV efficiency is addressed by using a high-gain electron multiplier. The photocathode is vapor-deposited onto the input cone of a Burle Magnum(TradeMark) multiplier. This system yields an extremely robust photon-driven electron source that can tolerate long, weeks or more, exposure to air with negligible degradation. The package is also small. When combined with the electron target, necessary vacuum fittings, and supporting components (but not including LED electronics or high-voltage sources), the entire modulated x-ray source weighs as little as 158 grams.

Fabrication of Single, Vertically Aligned Carbon Nanotubes in 3D Nanoscale Architectures

NASA Technical Reports Server (NTRS)

Kaul, Anupama B.; Megerian, Krikor G.; Von Allmen, Paul A.; Baron, Richard L.

2010-01-01

Plasma-enhanced chemical vapor deposition (PECVD) and high-throughput manufacturing techniques for integrating single, aligned carbon nanotubes (CNTs) into novel 3D nanoscale architectures have been developed. First, the PECVD growth technique ensures excellent alignment of the tubes, since the tubes align in the direction of the electric field in the plasma as they are growing. Second, the tubes generated with this technique are all metallic, so their chirality is predetermined, which is important for electronic applications. Third, a wafer-scale manufacturing process was developed that is high-throughput and low-cost, and yet enables the integration of just single, aligned tubes with nanoscale 3D architectures with unprecedented placement accuracy and does not rely on e-beam lithography. Such techniques should lend themselves to the integration of PECVD grown tubes for applications ranging from interconnects, nanoelectromechanical systems (NEMS), sensors, bioprobes, or other 3D electronic devices. Chemically amplified polyhydroxystyrene-resin-based deep UV resists were used in conjunction with excimer laser-based (lambda = 248 nm) step-and-repeat lithography to form Ni catalyst dots = 300 nm in diameter that nucleated single, vertically aligned tubes with high yield using dc PECVD growth. This is the first time such chemically amplified resists have been used, resulting in the nucleation of single, vertically aligned tubes. In addition, novel 3D nanoscale architectures have been created using topdown techniques that integrate single, vertically aligned tubes. These were enabled by implementing techniques that use deep-UV chemically amplified resists for small-feature-size resolution; optical lithography units that allow unprecedented control over layer-to-layer registration; and ICP (inductively coupled plasma) etching techniques that result in near-vertical, high-aspect-ratio, 3D nanoscale architectures, in conjunction with the use of materials that are structurally and chemically compatible with the high-temperature synthesis of the PECVD-grown tubes. The techniques offer a wafer-scale process solution for integrating single PECVD-grown nanotubes into novel architectures that should accelerate their integration in 3D electronics in general. NASA can directly benefit from this technology for its extreme-environment planetary missions. Current Si transistors are inherently more susceptible to high radiation, and do not tolerate extremes in temperature. These novel 3D nanoscale architectures can form the basis for NEMS switches that are inherently less susceptible to radiation or to thermal extremes.

High volume nanoscale roll-based imprinting using jet and flash imprint lithography

NASA Astrophysics Data System (ADS)

Ahn, Se Hyun; Miller, Michael; Yang, Shuqiang; Ganapathisubramanian, Maha; Menezes, Marlon; Singh, Vik; Wan, Fen; Choi, Jin; Xu, Frank; LaBrake, Dwayne; Resnick, Douglas J.; Hofemann, Paul; Sreenivasan, S. V.

2014-03-01

Extremely large-area roll-to-roll manufacturing on flexible substrates is ubiquitous for applications such as paper and plastic processing. The challenge is to extend this approach to the realm of nanopatterning and realize similar benefits. Display applications, including liquid crystal (LCD), organic light emitting diode (OLED) and flexible displays are particularly interesting because of the ability to impact multiple levels in the basic display. Of particular interest are the polarizer, DBEF, thin film transistor and color filter; roll-based imprinting has the opportunity to create high performance components within the display while improving the cost of ownership of the panel. Realization of these devices requires both a scalable imprinting technology and tool. In this paper, we introduce a high volume roll-based nanopatterning system, the LithoFlex 350TM. The LithoFlex 350 uses an inkjet based imprinting process similar to the technology demonstrator tool, the LithoFlex 100, introduced in 2012. The width of the web is 350mm and patterning width is 300mm. The system can be configured either for Plate-to-Roll (P2R) imprinting (in which a rigid template is used to pattern the flexible web material) or for Roll-to-Plate imprinting (R2P) (in which a web based template is used to pattern either wafers or panels). Also described in this paper are improvements to wire grid polarizer devices. By optimizing the deposition, patterning and etch processes, we have been able to create working WGPs with transmittance and extinction ratios as high as 44% and 50,000, respectively.

Anthropogenic warming has increased drought risk in California.

PubMed

Diffenbaugh, Noah S; Swain, Daniel L; Touma, Danielle

2015-03-31

California is currently in the midst of a record-setting drought. The drought began in 2012 and now includes the lowest calendar-year and 12-mo precipitation, the highest annual temperature, and the most extreme drought indicators on record. The extremely warm and dry conditions have led to acute water shortages, groundwater overdraft, critically low streamflow, and enhanced wildfire risk. Analyzing historical climate observations from California, we find that precipitation deficits in California were more than twice as likely to yield drought years if they occurred when conditions were warm. We find that although there has not been a substantial change in the probability of either negative or moderately negative precipitation anomalies in recent decades, the occurrence of drought years has been greater in the past two decades than in the preceding century. In addition, the probability that precipitation deficits co-occur with warm conditions and the probability that precipitation deficits produce drought have both increased. Climate model experiments with and without anthropogenic forcings reveal that human activities have increased the probability that dry precipitation years are also warm. Further, a large ensemble of climate model realizations reveals that additional global warming over the next few decades is very likely to create ∼ 100% probability that any annual-scale dry period is also extremely warm. We therefore conclude that anthropogenic warming is increasing the probability of co-occurring warm-dry conditions like those that have created the acute human and ecosystem impacts associated with the "exceptional" 2012-2014 drought in California.

Anthropogenic warming has increased drought risk in California

PubMed Central

Diffenbaugh, Noah S.; Swain, Daniel L.; Touma, Danielle

2015-01-01

California is currently in the midst of a record-setting drought. The drought began in 2012 and now includes the lowest calendar-year and 12-mo precipitation, the highest annual temperature, and the most extreme drought indicators on record. The extremely warm and dry conditions have led to acute water shortages, groundwater overdraft, critically low streamflow, and enhanced wildfire risk. Analyzing historical climate observations from California, we find that precipitation deficits in California were more than twice as likely to yield drought years if they occurred when conditions were warm. We find that although there has not been a substantial change in the probability of either negative or moderately negative precipitation anomalies in recent decades, the occurrence of drought years has been greater in the past two decades than in the preceding century. In addition, the probability that precipitation deficits co-occur with warm conditions and the probability that precipitation deficits produce drought have both increased. Climate model experiments with and without anthropogenic forcings reveal that human activities have increased the probability that dry precipitation years are also warm. Further, a large ensemble of climate model realizations reveals that additional global warming over the next few decades is very likely to create ∼100% probability that any annual-scale dry period is also extremely warm. We therefore conclude that anthropogenic warming is increasing the probability of co-occurring warm–dry conditions like those that have created the acute human and ecosystem impacts associated with the “exceptional” 2012–2014 drought in California. PMID:25733875

Extreme Fire Severity Patterns in Topographic, Convective and Wind-Driven Historical Wildfires of Mediterranean Pine Forests

PubMed Central

Lecina-Diaz, Judit; Alvarez, Albert; Retana, Javier

2014-01-01

Crown fires associated with extreme fire severity are extremely difficult to control. We have assessed fire severity using differenced Normalized Burn Ratio (dNBR) from Landsat imagery in 15 historical wildfires of Pinus halepensis Mill. We have considered a wide range of innovative topographic, fuel and fire behavior variables with the purposes of (1) determining the variables that influence fire severity patterns among fires (considering the 15 wildfires together) and (2) ascertaining whether different variables affect extreme fire severity within the three fire types (topographic, convective and wind-driven fires). The among-fires analysis showed that fires in less arid climates and with steeper slopes had more extreme severity. In less arid conditions there was more crown fuel accumulation and closer forest structures, promoting high vertical and horizontal fuel continuity and extreme fire severity. The analyses carried out for each fire separately (within fires) showed more extreme fire severity in areas in northern aspects, with steeper slopes, with high crown biomass and in climates with more water availability. In northern aspects solar radiation was lower and fuels had less water limitation to growth which, combined with steeper slopes, produced more extreme severity. In topographic fires there was more extreme severity in northern aspects with steeper slopes and in areas with more water availability and high crown biomass; in convection-dominated fires there was also more extreme fire severity in northern aspects with high biomass; while in wind-driven fires there was only a slight interaction between biomass and water availability. This latter pattern could be related to the fact that wind-driven fires spread with high wind speed, which could have minimized the effect of other variables. In the future, and as a consequence of climate change, new zones with high crown biomass accumulated in non-common drought areas will be available to burn as extreme severity wildfires. PMID:24465492

Extreme fire severity patterns in topographic, convective and wind-driven historical wildfires of Mediterranean pine forests.

PubMed

Lecina-Diaz, Judit; Alvarez, Albert; Retana, Javier

2014-01-01

Crown fires associated with extreme fire severity are extremely difficult to control. We have assessed fire severity using differenced Normalized Burn Ratio (dNBR) from Landsat imagery in 15 historical wildfires of Pinus halepensis Mill. We have considered a wide range of innovative topographic, fuel and fire behavior variables with the purposes of (1) determining the variables that influence fire severity patterns among fires (considering the 15 wildfires together) and (2) ascertaining whether different variables affect extreme fire severity within the three fire types (topographic, convective and wind-driven fires). The among-fires analysis showed that fires in less arid climates and with steeper slopes had more extreme severity. In less arid conditions there was more crown fuel accumulation and closer forest structures, promoting high vertical and horizontal fuel continuity and extreme fire severity. The analyses carried out for each fire separately (within fires) showed more extreme fire severity in areas in northern aspects, with steeper slopes, with high crown biomass and in climates with more water availability. In northern aspects solar radiation was lower and fuels had less water limitation to growth which, combined with steeper slopes, produced more extreme severity. In topographic fires there was more extreme severity in northern aspects with steeper slopes and in areas with more water availability and high crown biomass; in convection-dominated fires there was also more extreme fire severity in northern aspects with high biomass; while in wind-driven fires there was only a slight interaction between biomass and water availability. This latter pattern could be related to the fact that wind-driven fires spread with high wind speed, which could have minimized the effect of other variables. In the future, and as a consequence of climate change, new zones with high crown biomass accumulated in non-common drought areas will be available to burn as extreme severity wildfires.

Effect of antecedent terrestrial land-use on C and N cycling in created wetlands

NASA Astrophysics Data System (ADS)

McCalley, C. K.; Al Graiti, T.; Williams, T.; Huang, S.; McGowan, M. B.; Eddingsaas, N. C.; Tyler, A. C.

2017-12-01

Land-use legacies and their interaction with both management actions and climate variability has a poorly characterized impact on the development of ecosystem functions and the trajectory of climate-carbon feedbacks. The complex structure-function relationships in wetlands foster delivery of valuable, climate sensitive, ecosystem services (carbon sequestration, nutrient removal, flood control, etc.) but also make them susceptible to colonization by invasive plants and lead to emission of key greenhouse gases. This project uses created wetland ecosystems as a model to understand how heterogeneity in antecedent conditions interacts with management options to create unique structure-function scenarios and a range of climate feedback outcomes. We utilized ongoing experiments in created wetlands that differ in antecedent conditions (crop agriculture, livestock grazing) and investigated how management options (invasive species removal, organic matter addition) interact with legacy impacts to promote key ecosystem functions, including greenhouse gas emissions, carbon sequestration, denitrification and plant biodiversity. The effects of antecedent land-use on soil chemistry, coupled with hydrologic patterns resulted in wetlands with divergent C and N dynamics despite their similar creation history. Additionally, the occurrence of extreme weather events (drought and excessive flooding) during the study period highlighted the overarching role that increased climate variability will play in determining key ecosystem processes in wetlands. Responses to management were linked to hydro-period: while organic matter addition successfully increased soil organic matter to more closely replicate natural systems at all sites, it had the largest impact on C and N cycling when soils were saturated. Overall, environmental conditions that promoted saturated soils, both those shaped by human activities or climate extremes, enhanced primary productivity, nutrient removal and greenhouse gas production as well as decreased soil respiration.

High N, dry: Experimental nitrogen deposition exacerbates native shrub loss and nonnative plant invasion during extreme drought.

PubMed

Valliere, Justin M; Irvine, Irina C; Santiago, Louis; Allen, Edith B

2017-10-01

Hotter, longer, and more frequent global change-type drought events may profoundly impact terrestrial ecosystems by triggering widespread vegetation mortality. However, severe drought is only one component of global change, and ecological effects of drought may be compounded by other drivers, such as anthropogenic nitrogen (N) deposition and nonnative plant invasion. Elevated N deposition, for example, may reduce drought tolerance through increased plant productivity, thereby contributing to drought-induced mortality. High N availability also often favors invasive, nonnative plant species, and the loss of woody vegetation due to drought may create a window of opportunity for these invaders. We investigated the effects of multiple levels of simulated N deposition on a Mediterranean-type shrubland plant community in southern California from 2011 to 2016, a period coinciding with an extreme, multiyear drought in the region. We hypothesized that N addition would increase native shrub productivity, but that this would increase susceptibility to drought and result in increased shrub loss over time. We also predicted that N addition would favor nonnatives, especially annual grasses, leading to higher biomass and cover of these species. Consistent with these hypotheses, we found that high N availability increased native shrub canopy loss and mortality, likely due to the higher productivity and leaf area and reduced water-use efficiency we observed in shrubs subject to N addition. As native shrub cover declined, we also observed a concomitant increase in cover and biomass of nonnative annuals, particularly under high levels of experimental N deposition. Together, these results suggest that the impacts of extended drought on shrubland ecosystems may be more severe under elevated N deposition, potentially contributing to the widespread loss of native woody species and vegetation-type conversion. © 2017 John Wiley & Sons Ltd.

Low-mass dielectrons in pp, p-Pb and Pb-Pb collisions measured by the ALICE Experiment

NASA Astrophysics Data System (ADS)

Vorobyev, Ivan

2018-02-01

Dielectrons produced in ultra-relativistic heavy-ion collisions at the LHC provide a unique probe of the system evolution as they are unperturbed by final-state interactions. The dielectron continuum is extremely rich in physics sources: on top of ordinary Dalitz and resonance decays of pseudoscalar and vector mesons, thermal black-body radiation is of particular interest as it carries information about the temperature of the hot and dense system created in such collisions. The dielectron invariant-mass distribution is furthermore sensitive to medium modifications of the spectral function of short-lived vector mesons that are linked to the potential restoration of chiral symmetry at high temperatures. Correlated electron pairs from semi-leptonic charm and beauty decays provide complementary information about the heavy-quark energy loss.

Gujarat, Western India

NASA Technical Reports Server (NTRS)

2002-01-01

Extremely high sediment loads are delivered to the Arabian Sea along the coast of Pakistan (upper left) and western India. In the case of the Indus River (far upper left) this sedimentation, containing large quantities of desert sand, combines with wave action to create a large sand-bar like delta. In the arid environment, the delta lacks much vegetation, but contains numerous mangrove-lined channels. This true-color image from May 2001 shows the transition from India's arid northwest to the wetter regions farther south along the coast. The increase in vegetation along the coast is brought about by the moisture trapping effect of the Western Ghats Mountain Range that runs north-south along the coast. Heavy sediment is visible in the Gulf of Kachchh (north) and the Gulf of Khambhat(south), which surround the Gujarat Peninsula.

City-integrated renewable energy for urban sustainability.

PubMed

Kammen, Daniel M; Sunter, Deborah A

2016-05-20

To prepare for an urban influx of 2.5 billion people by 2050, it is critical to create cities that are low-carbon, resilient, and livable. Cities not only contribute to global climate change by emitting the majority of anthropogenic greenhouse gases but also are particularly vulnerable to the effects of climate change and extreme weather. We explore options for establishing sustainable energy systems by reducing energy consumption, particularly in the buildings and transportation sectors, and providing robust, decentralized, and renewable energy sources. Through technical advancements in power density, city-integrated renewable energy will be better suited to satisfy the high-energy demands of growing urban areas. Several economic, technical, behavioral, and political challenges need to be overcome for innovation to improve urban sustainability. Copyright © 2016, American Association for the Advancement of Science.

Designer Drugs: A Synthetic Catastrophe.

PubMed

Fratantonio, James; Andrade, Lawrence; Febo, Marcelo

Synthetic stimulants can cause hallucinations, aggressive behaviors, death and are sometimes legal. These substances are sold as plant food and bath salts that are "Not for Human Consumption", therefore skirting the 1986 Federal Analogue Act and giving a false pretense of safety. Studies have proved that these substances are toxic, have a high abuse potential, and are becoming extremely prevalent in the United States. This creates a dilemma for law enforcement agents, hospitals, and substance use disorder treatment centers. Urine Drug Testing is utilized as a clinical diagnostic tool in substance use disorder treatment centers, and the furious pace at which new synthetic stimulants are introduced to the black market are making the detection via urine increasingly difficult. This article will discuss the prevalence, pharmacology and difficulty developing laboratory assays to detect synthetic stimulants.

From damage to discovery via virtual unwrapping: Reading the scroll from En-Gedi

PubMed Central

Seales, William Brent; Parker, Clifford Seth; Segal, Michael; Tov, Emanuel; Shor, Pnina; Porath, Yosef

2016-01-01

Computer imaging techniques are commonly used to preserve and share readable manuscripts, but capturing writing locked away in ancient, deteriorated documents poses an entirely different challenge. This software pipeline—referred to as “virtual unwrapping”—allows textual artifacts to be read completely and noninvasively. The systematic digital analysis of the extremely fragile En-Gedi scroll (the oldest Pentateuchal scroll in Hebrew outside of the Dead Sea Scrolls) reveals the writing hidden on its untouchable, disintegrating sheets. Our approach for recovering substantial ink-based text from a damaged object results in readable columns at such high quality that serious critical textual analysis can occur. Hence, this work creates a new pathway for subsequent textual discoveries buried within the confines of damaged materials. PMID:27679821

Beware! A simple renal cyst could be a hydatid cyst.

PubMed

Sehgal, Nidhi; Priyadarshi, Vinod

2017-01-01

Kidney is one of the most common sites for the cyst formation in the body, and the management of simple cysts is required entirely for its symptoms and complications. Surgical decortication is an established treatment for a large and symptomatic simple renal cyst. On the other hand, hydatid cysts of the kidney are usually multiloculated complex or calcified cysts and are quite rare. Their surgical treatment also differs and requires complete excision with pericystectomy or partial/complete nephrectomy depending upon residual functional parenchyma, using extreme caution to avoid spillage, recurrence or development of severe anaphylactic shock. A simple cyst harboring a hydatid cyst is highly uncommon and quite dangerous; as if not diagnosed preoperatively, it can create huge trouble for both the patient and the operating surgeon which happened in the present case.

Materials Manufactured from 3D Printed Synthetic Biology Arrays

NASA Technical Reports Server (NTRS)

Gentry, Diana; Micks, Ashley

2013-01-01

Many complex, biologically-derived materials have extremely useful properties (think wood or silk), but are unsuitable for space-related applications due to production, manufacturing, or processing limitations. Large-scale ecosystem-based production, such as raising and harvesting trees for wood, is impractical in a self-contained habitat such as a space station or potential Mars colony. Manufacturing requirements, such as the specialized equipment needed to harvest and process cotton, add too much upmass for current launch technology. Cells in nature are already highly specialized for making complex biological materials on a micro scale. We envision combining these strengths with the recently emergent technologies of synthetic biology and 3D printing to create 3D-structured arrays of cells that are bioengineered to secrete different materials in a specified three-dimensional pattern.

Blood brain barrier: a challenge for effectual therapy of brain tumors.

PubMed

Bhowmik, Arijit; Khan, Rajni; Ghosh, Mrinal Kanti

2015-01-01

Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier.

Extreme AO Observations of Two Triple Asteroid Systems with SPHERE

NASA Astrophysics Data System (ADS)

Yang, B.; Wahhaj, Z.; Beauvalet, L.; Marchis, F.; Dumas, C.; Marsset, M.; Nielsen, E. L.; Vachier, F.

2016-04-01

We present the discovery of a new satellite of asteroid (130) Elektra—S/2014 (130) 1—in differential imaging and in integral field spectroscopy data over multiple epochs obtained with Spectro-Polarimetric High-contrast Exoplanet Research/Very Large Telescope. This new (second) moonlet of Elektra is about 2 km across, on an eccentric orbit, and about 500 km away from the primary. For a comparative study, we also observed another triple asteroid system, (93) Minerva. For both systems, component-resolved reflectance spectra of the satellites and primary were obtained simultaneously. No significant spectral difference was observed between the satellites and the primary for either triple system. We find that the moonlets in both systems are more likely to have been created by sub-disruptive impacts as opposed to having been captured.

Generating Localized Nonlinear Excitations in the Fermi-Pasta-Ulam-Tsingou chains

NASA Astrophysics Data System (ADS)

Westley, Alexandra; Sen, Surajit

Here, we will discuss properties of energy trapping in the decorated Fermi-Pasta-Ulam-Tsingou (FPUT) mass-spring chains with quadratic and quartic coupling terms. It is well-known that the FPUT system admits highly localized nonlinear excitations (LNE) which are stable for long periods of time. We seek to generate these LNEs at will by creating regions in the chain of stiffer or softer springs, or by placing mass impurities throughout. We will show that NLEs tend to coalesce in regions of stiff springs from random perturbations throughout the system. These locations may serve as extremely powerful energy traps or heat sinks in certain materials. Furthermore, we will demonstrate that this process occurs by means of trapping solitary (or anti-solitary) waves into tight spaces.

Quantifying the relationship between extreme air pollution events and extreme weather events

NASA Astrophysics Data System (ADS)

Zhang, Henian; Wang, Yuhang; Park, Tae-Won; Deng, Yi

2017-05-01

Extreme weather events can strongly affect surface air quality, which has become a major environmental factor to affect human health. Here, we examined the relationship between extreme ozone and PM2.5 (particular matter with an aerodynamic diameter less than 2.5 μm) events and the representative meteorological parameters such as daily maximum temperature (Tmax), minimum relative humidity (RHmin), and minimum wind speed (Vmin), using the location-specific 95th or 5th percentile threshold derived from historical reanalysis data (30 years for ozone and 10 years for PM2.5). We found that ozone and PM2.5 extremes were decreasing over the years, reflecting EPA's tightened standards and effort on reducing the corresponding precursor's emissions. Annual ozone and PM2.5 extreme days were highly correlated with Tmax and RHmin, especially in the eastern U.S. They were positively (negatively) correlated with Vmin in urban (rural and suburban) stations. The overlapping ratios of ozone extreme days with Tmax were fairly constant, about 32%, and tended to be high in fall and low in winter. Ozone extreme days were most sensitive to Tmax, then RHmin, and least sensitive to Vmin. The majority of ozone extremes occurred when Tmax was between 300 K and 320 K, RHmin was less than 40%, and Vmin was less than 3 m/s. The number of annual extreme PM2.5 days was highly positively correlated with the extreme RHmin/Tmax days, with correlation coefficient between PM2.5/RHmin highest in urban and suburban regions and the correlation coefficient between PM2.5/Tmax highest in rural area. Tmax has more impact on PM2.5 extreme over the eastern U.S. Extreme PM2.5 days were more likely to occur at low RH conditions in the central and southeastern U.S., especially during spring time, and at high RH conditions in the northern U.S. and the Great Plains. Most extreme PM2.5 events occurred when Tmax was between 300 K and 320 K and RHmin was between 10% and 50%. Extreme PM2.5 days usually occurred when Vmin was under 2 m/s. However, during spring season in the Southeast and fall season in Northwest, high winds were found to accompany extreme PM2.5 days, likely reflecting the impact of fire emissions.

Understanding Single-Thread Meandering Rivers with High Sinuosity on Mars through Chemical Precipitation Experiments

NASA Astrophysics Data System (ADS)

Lim, Y.; Kim, W.

2015-12-01

Meandering rivers are extremely ubiquitous on Earth, yet it is only recently that single-thread experimental channels with low sinuosity have been created. In these recent experiments, as well as in natural rivers, vegetation plays a crucial role in maintaining a meandering pattern by adding cohesion to the bank and inhibiting erosion. The ancient, highly sinuous channels found on Mars are enigmatic because presumably vegetation did not exist on ancient Mars. Under the hypothesis that Martian meandering rivers formed by chemical precipitation on levees and flood plain deposits, we conducted carbonate flume experiments to investigate the formation and evolution of a single-thread meander pattern without vegetation. The flow recirculating in the flume is designed to accelerate chemical reactions - dissolution of limestone using CO2 gas to produce artificial spring water and precipitation of carbonates to increase cohesion- with precise control of water discharge, sediment discharge, and temperature. Preliminary experiments successfully created a single-thread meandering pattern through chemical processes. Carbonate deposits focused along the channel sides improved the bank stability and made them resistant to erosion, which led to a stream confined in a narrow path. The experimental channels showed lateral migration of the bend through cut bank and point bar deposits; intermittent floods created overbank flow and encouraged cut bank erosion, which enhanced lateral migration of the channel, while increase in sediment supply improved lateral point bar deposition, which balanced erosion and deposition rates. This mechanism may be applied to terrestrial single-thread and/or meandering rivers with little to no vegetation or before its introduction to Earth and also provide the link between meandering river records on Mars to changes in Martian surface conditions.

The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traits.

PubMed

Greven, Corina U; Merwood, Andrew; van der Meer, Jolanda M J; Haworth, Claire M A; Rommelse, Nanda; Buitelaar, Jan K

2016-04-01

Although attention deficit hyperactivity disorder (ADHD) is thought to reflect a continuously distributed quantitative trait, it is assessed through binary diagnosis or skewed measures biased towards its high, symptomatic extreme. A growing trend is to study the positive tail of normally distributed traits, a promising avenue, for example, to study high intelligence to increase power for gene-hunting for intelligence. However, the emergence of such a 'positive genetics' model has been tempered for ADHD due to poor phenotypic resolution at the low extreme. Overcoming this methodological limitation, we conduct the first study to assess the aetiologies of low extreme ADHD traits. In a population-representative sample of 2,143 twins, the Strength and Weaknesses of ADHD Symptoms and Normal behaviour (SWAN) questionnaire was used to assess ADHD traits on a continuum from low to high. Aetiological influences on extreme ADHD traits were estimated using DeFries-Fulker extremes analysis. ADHD traits were related to behavioural, cognitive and home environmental outcomes using regression. Low extreme ADHD traits were significantly influenced by shared environmental factors (23-35%) but were not significantly heritable. In contrast, high-extreme ADHD traits showed significant heritability (39-51%) but no shared environmental influences. Compared to individuals with high extreme or with average levels of ADHD traits, individuals with low extreme ADHD traits showed fewer internalizing and externalizing behaviour problems, better cognitive performance and more positive behaviours and positive home environmental outcomes. Shared environmental influences on low extreme ADHD traits may reflect passive gene-environment correlation, which arises because parents provide environments as well as passing on genes. Studying the low extreme opens new avenues to study mechanisms underlying previously neglected positive behaviours. This is different from the current deficit-based model of intervention, but congruent with a population-level approach to improving youth wellbeing. © 2015 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

Quantifying Urban Texture in Nairobi, Kenya and its Implications for Understanding Natural Hazard Impact

NASA Astrophysics Data System (ADS)

Taylor, Faith E.; Malamud, Bruce D.; Millington, James D. A.

2016-04-01

The configuration of infrastructure networks such as roads, drainage and power lines can both affect and be affected by natural hazards such as earthquakes, intense rain, wildfires and extreme temperatures. In this paper, we present and compare two methods to quantify urban topology on approximate scales of 0.0005 km2 to 10 km2 and create classifications of different 'urban textures' that relate to risk of natural hazard impact in an area. The methods we use focus on applicability in urban developing country settings, where access to high resolution and high quality data may be difficult. We use the city of Nairobi, Kenya to trial these methods. Nairobi has a population >3 million, and is a mix of informal settlements, residential and commercial development. The city and its immediate surroundings are subject to a variety of natural hazards such as floods, landslides, fires, drought, hail, heavy wind and extreme temperatures; all of these hazards can occur singly, but also have the potential for one to trigger another, thus providing a 'cascade' of hazards, or for two of the hazards to occur spatially and temporally near each other and interact. We use two measures of urban texture: (i) Street block textures, (ii) Google Earth land cover textures. Street block textures builds on the methodology of Louf and Barthelemy (2014) and uses Open Street Map data to analyse the shape, size, complexity and pattern of individual blocks of land created by fully enclosed loops of the major and minor road network of Nairobi. We find >4000 of these blocks ranging in size from approximately 0.0005 km2 to 10 km2, with approximately 5 classifications of urban texture. Google Earth land cover texture is a visual classification of homogeneous parcels of land performed in Google Earth using high-resolution airborne imagery and a qualitative criteria for each land cover type. Using the Google Earth land cover texture method, we identify >40 'urban textures' based on visual characteristics such as colour, texture, shadow and setting and have created a clear criteria for classifying an area based on its visual characteristics. These two methods for classifying urban texture in Nairobi are compared in a GIS and in the field to investigate whether there is a link between the visual appearance of an area and its network topology. From these urban textures, we may start to identify areas where (a) urban texture types may indicate a relative propensity to certain hazards and their interactions and (b) urban texture types that may increase or decrease the impact of a hazard that occurs in that area.

Structure-Based Engineering of an Artificially Generated NADP+-Dependent d-Amino Acid Dehydrogenase.

PubMed

Hayashi, Junji; Seto, Tomonari; Akita, Hironaga; Watanabe, Masahiro; Hoshino, Tamotsu; Yoneda, Kazunari; Ohshima, Toshihisa; Sakuraba, Haruhiko

2017-06-01

A stable NADP + -dependent d-amino acid dehydrogenase (DAADH) was recently created from Ureibacillus thermosphaericus meso -diaminopimelate dehydrogenase through site-directed mutagenesis. To produce a novel DAADH mutant with different substrate specificity, the crystal structure of apo-DAADH was determined at a resolution of 1.78 Å, and the amino acid residues responsible for the substrate specificity were evaluated using additional site-directed mutagenesis. By introducing a single D94A mutation, the enzyme's substrate specificity was dramatically altered; the mutant utilized d-phenylalanine as the most preferable substrate for oxidative deamination and had a specific activity of 5.33 μmol/min/mg at 50°C, which was 54-fold higher than that of the parent DAADH. In addition, the specific activities of the mutant toward d-leucine, d-norleucine, d-methionine, d-isoleucine, and d-tryptophan were much higher (6 to 25 times) than those of the parent enzyme. For reductive amination, the D94A mutant exhibited extremely high specific activity with phenylpyruvate (16.1 μmol/min/mg at 50°C). The structures of the D94A-Y224F double mutant in complex with NADP + and in complex with both NADPH and 2-keto-6-aminocapronic acid (lysine oxo-analogue) were then determined at resolutions of 1.59 Å and 1.74 Å, respectively. The phenylpyruvate-binding model suggests that the D94A mutation prevents the substrate phenyl group from sterically clashing with the side chain of Asp94. A structural comparison suggests that both the enlarged substrate-binding pocket and enhanced hydrophobicity of the pocket are mainly responsible for the high reactivity of the D94A mutant toward the hydrophobic d-amino acids with bulky side chains. IMPORTANCE In recent years, the potential uses for d-amino acids as source materials for the industrial production of medicines, seasonings, and agrochemicals have been growing. To date, several methods have been used for the production of d-amino acids, but all include tedious steps. The use of NAD(P) + -dependent d-amino acid dehydrogenase (DAADH) makes single-step production of d-amino acids from oxo-acid analogs and ammonia possible. We recently succeeded in creating a stable DAADH and demonstrated that it is applicable for one-step synthesis of d-amino acids, such as d-leucine and d-isoleucine. As the next step, the creation of an enzyme exhibiting different substrate specificity and higher catalytic efficiency is a key to the further development of d-amino acid production. In this study, we succeeded in creating a novel mutant exhibiting extremely high catalytic activity for phenylpyruvate amination. Structural insight into the mutant will be useful for further improvement of DAADHs. Copyright © 2017 American Society for Microbiology.

Structure-Based Engineering of an Artificially Generated NADP+-Dependent d-Amino Acid Dehydrogenase

PubMed Central

Hayashi, Junji; Seto, Tomonari; Akita, Hironaga; Watanabe, Masahiro; Hoshino, Tamotsu; Yoneda, Kazunari; Ohshima, Toshihisa

2017-01-01

ABSTRACT A stable NADP+-dependent d-amino acid dehydrogenase (DAADH) was recently created from Ureibacillus thermosphaericus meso-diaminopimelate dehydrogenase through site-directed mutagenesis. To produce a novel DAADH mutant with different substrate specificity, the crystal structure of apo-DAADH was determined at a resolution of 1.78 Å, and the amino acid residues responsible for the substrate specificity were evaluated using additional site-directed mutagenesis. By introducing a single D94A mutation, the enzyme's substrate specificity was dramatically altered; the mutant utilized d-phenylalanine as the most preferable substrate for oxidative deamination and had a specific activity of 5.33 μmol/min/mg at 50°C, which was 54-fold higher than that of the parent DAADH. In addition, the specific activities of the mutant toward d-leucine, d-norleucine, d-methionine, d-isoleucine, and d-tryptophan were much higher (6 to 25 times) than those of the parent enzyme. For reductive amination, the D94A mutant exhibited extremely high specific activity with phenylpyruvate (16.1 μmol/min/mg at 50°C). The structures of the D94A-Y224F double mutant in complex with NADP+ and in complex with both NADPH and 2-keto-6-aminocapronic acid (lysine oxo-analogue) were then determined at resolutions of 1.59 Å and 1.74 Å, respectively. The phenylpyruvate-binding model suggests that the D94A mutation prevents the substrate phenyl group from sterically clashing with the side chain of Asp94. A structural comparison suggests that both the enlarged substrate-binding pocket and enhanced hydrophobicity of the pocket are mainly responsible for the high reactivity of the D94A mutant toward the hydrophobic d-amino acids with bulky side chains. IMPORTANCE In recent years, the potential uses for d-amino acids as source materials for the industrial production of medicines, seasonings, and agrochemicals have been growing. To date, several methods have been used for the production of d-amino acids, but all include tedious steps. The use of NAD(P)+-dependent d-amino acid dehydrogenase (DAADH) makes single-step production of d-amino acids from oxo-acid analogs and ammonia possible. We recently succeeded in creating a stable DAADH and demonstrated that it is applicable for one-step synthesis of d-amino acids, such as d-leucine and d-isoleucine. As the next step, the creation of an enzyme exhibiting different substrate specificity and higher catalytic efficiency is a key to the further development of d-amino acid production. In this study, we succeeded in creating a novel mutant exhibiting extremely high catalytic activity for phenylpyruvate amination. Structural insight into the mutant will be useful for further improvement of DAADHs. PMID:28363957

An Experimental Review on Heavy-Flavor v 2 in Heavy-Ion Collision

DOE PAGES

Nasim, Md.; Esha, Roli; Huang, Huan Zhong

2016-01-01

For overmore » a decade now, the primary purpose of relativistic heavy-ion collisions at the Relativistic Heavy-Ion Collider (RHIC) and the Large Hadron Collider (LHC) has been to study the properties of QCD matter under extreme conditions—high temperature and high density. The heavy-ion experiments at both RHIC and LHC have recorded a wealth of data in p+p, p+Pb, d+Au, Cu+Cu, Cu+Au, Au+Au, Pb+Pb, and U+U collisions at energies ranging from s N N = 7.7  GeV to 7 TeV. Heavy quarks are considered good probe to study the QCD matter created in relativistic collisions due to their very large mass and other unique properties. A precise measurement of various properties of heavy-flavor hadrons provides an insight into the fundamental properties of the hot and dense medium created in these nucleus-nucleus collisions, such as transport coefficient and thermalization and hadronization mechanisms. The main focus of this paper is to present a review on the measurements of azimuthal anisotropy of heavy-flavor hadrons and to outline the scientific opportunities in this sector due to future detector upgrade. We will mainly discuss the elliptic flow of open charmed meson ( D -meson), J / ψ , and leptons from heavy-flavor decay at RHIC and LHC energy.« less

The Effects of Filter Cutoff Frequency on Musculoskeletal Simulations of High-Impact Movements.

PubMed

Tomescu, Sebastian; Bakker, Ryan; Beach, Tyson A C; Chandrashekar, Naveen

2018-02-12

Estimation of muscle forces through musculoskeletal simulation is important in understanding human movement and injury. Unmatched filter frequencies used to low-pass filter marker and force platform data can create artifacts during inverse dynamics analysis, but their effects on muscle force calculations are unknown. The objective of this study was to determine the effects of filter cutoff frequency on simulation parameters and magnitudes of lower extremity muscle and resultant joint contact forces during a high-impact maneuver. Eight participants performed a single leg jump-landing. Kinematics were captured with a 3D motion capture system and ground reaction forces were recorded with a force platform. The marker and force platform data were filtered using two matched filter frequencies (10-10Hz, 15-15Hz) and two unmatched frequencies (10-50Hz, 15-50Hz). Musculoskeletal simulations using Computed Muscle Control were performed in OpenSim. The results revealed significantly higher peak quadriceps (13%), hamstrings (48%), and gastrocnemius forces (69%) in the unmatched (10-50Hz, 15-50Hz) conditions than in the matched (10-10Hz, 15-15Hz) conditions (p<0.05). Resultant joint contact forces and reserve (non-physiologic) moments were similarly larger in the unmatched filter categories (p<0.05). This study demonstrated that artifacts created from filtering with unmatched filter cutoffs result in altered muscle forces and dynamics which are not physiologic.

Social Justice, Children's Needs and Rights: An Approach to Planning

ERIC Educational Resources Information Center

Sims, Margaret

2015-01-01

Commonly, planning for children involves comparing what they know against a curriculum or learning framework which identifies what they should know. Early childhood educators are then expected to create learning opportunities to help fill the gap between these two extremes. In this paper I argue that such an approach does not honour the…

"Find the Strength in Every Teacher": Urban Middle School Teachers' Perceptions of Effective Change Leadership

ERIC Educational Resources Information Center

Allen, Timothy Clancy

2013-01-01

Urban middle schools face many accountability measures which often create the need for school improvement. Leading urban middle schools through the change process is extremely challenging for principals. The combination of leading change, leading urban schools, and leading middle schools is an uphill climb. Teachers' perceptions of leadership…

The Art of Video Games

ERIC Educational Resources Information Center

Johnson, Mark M.

2012-01-01

The Smithsonian American Art Museum has created and will tour an exhibition on a most unusual but extremely popular art form--"The Art of Video Games." As one of the largest and first of its type, this exhibition will document and explore a 40-year evolution of video games as an artistic medium, with a focus on striking visual effects and the…

Stormwise: Integrating arboriculture and silviculture to create storm-resilient roadside forests

Treesearch

Jeffrey S. Ward; Thomas E. Worthley; Thomas J. Degnan; Joseph P. Barsky

2017-01-01

The band of trees within 30 m of roads (i.e., roadside forests) is often left unmanaged during traditional forest management activities because of liability concerns about inadvertently causing a vehicular accident or damaging utility lines during harvests. The trees in these same neglected forests often cause extensive utility outages and road blockages during extreme...

Reading Skills among Students with Intellectual Disabilities

ERIC Educational Resources Information Center

Ratz, Christoph; Lenhard, Wolfgang

2013-01-01

Students with intellectual disabilities (ID) display an extremely wide variety of skills in the field of literacy, and the ability to read and write are central learning aims in the education of students with ID. It is vital to gain detailed knowledge on the literacy skills of students with ID in order to plan instruction, create learning…

Criminal Intent with Property: A Study of Real Estate Fraud Prediction and Detection

ERIC Educational Resources Information Center

Blackman, David H.

2013-01-01

The large number of real estate transactions across the United States, combined with closing process complexity, creates extremely large data sets that conceal anomalies indicative of fraud. The quantitative amount of damage due to fraud is immeasurable to the lives of individuals who are victims, not to mention the financial impact to…

Libraries in Today's Digital Age: The Copyright Controversy. ERIC Digest.

ERIC Educational Resources Information Center

Russell, Carrie

This digest focuses on the continuing ambiguities libraries and their users face in dealing with copyright in the digital environment. In the networked digital world, the basic principles of copyright are more difficult to apply. Digital copies are easy to create, modify, and manipulate, they are extremely easy to distribute widely over networks,…

Western sword fern avoids the extreme drought of 2012-2014

Treesearch

Emily E. Burns; Peter Cowan; Wendy Baxter; Deborah Zierten; Jarmilla Pittermann

2017-01-01

The California drought of 2012 to 2014 was the most severe drought on record for the last century and likely millennium. Warm temperatures with below-average precipitation compounded over the three-year period, creating significant and sustained aridity over the course of three growing seasons throughout the coast redwood ecosystem. The citizen science project, Fern...

Ownership and ecosystem as sources of spatial heterogeneity in a forested landscape, Wisconsin, USA

Treesearch

Thomas R. Crow; George E. Host; David J. Mladenoff

1999-01-01

The interaction between physical environment and land ownership in creating spatial heterogeneity was studied in largely forested landscapes of northern Wisconsin, USA. A stratified random approach was used in which 2500-ha plots representing two ownerships (National Forest and private non-industrial) were located within two regional ecosystems (extremely well-drained...

Learning in LAMS: Lesson from a Student Teacher Exploring Gene Ethics

ERIC Educational Resources Information Center

Dennis, Carina

2012-01-01

Due to its complex and microscopic nature, genetics is a difficult subject for many learners to conceptually grasp. Graphics, animation and video material can be extremely helpful to their understanding. A wealth of educational online content about genetics has been created over the past decade in the wake of the human genome being sequenced.…

Gravitational self-force meets the post-Newtonian approximation in extreme-mass ratio inspiral of binary black holes

NASA Astrophysics Data System (ADS)

Detweiler, Steven

2010-02-01

Post-Newtonian analysis, numerical relativity and, now, perturbation-based gravitational self-force analysis are all being used to describe various aspects of black hole binary systems. Recent comparisons between self-force analysis, with m1m2, and post-Newtonian analysis, with v/c 1 show excellent agreement in their common domain of validity. This lends credence to the two very different regularization procedures which are invoked in these approximations. When self-force analysis is able to create gravitational waveforms from extreme mass-ratio inspiral, then unprecedented cross cultural comparisons of these three distinct approaches to understanding gravitational waves will reveal the strengths and weaknesses of each. )

The Extreme-ultraviolet Emission from Sun-grazing Comets

NASA Technical Reports Server (NTRS)

Bryans, Paul; Pesnell, William D.

2012-01-01

The Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory has observed two Sun-grazing comets as they passed through the solar atmosphere. Both passages resulted in a measurable enhancement of extreme-ultraviolet (EUV) radiance in several of the AIA bandpasses.We explain this EUV emission by considering the evolution of the cometary atmosphere as it interacts with the ambient solar atmosphere. Molecules in the comet rapidly sublimate as it approaches the Sun. They are then photodissociated by the solar radiation field to create atomic species. Subsequent ionization of these atoms produces a higher abundance of ions than normally present in the corona and results in EUV emission in the wavelength ranges of the AIA telescope passbands.

Proof of concept of the ability of the kinect to quantify upper extremity function in dystrophinopathy.

PubMed

Lowes, Linda P; Alfano, Lindsay N; Yetter, Brent A; Worthen-Chaudhari, Lise; Hinchman, William; Savage, Jordan; Samona, Patrick; Flanigan, Kevin M; Mendell, Jerry R

2013-03-14

Individuals with dystrophinopathy lose upper extremity strength in proximal muscles followed by those more distal. Current upper extremity evaluation tools fail to fully capture changes in upper extremity strength and function across the disease spectrum as they tend to focus solely on distal ability. The Kinect by Microsoft is a gaming interface that can gather positional information about an individual's upper extremity movement which can be used to determine functional reaching volume, velocity of movement, and rate of fatigue while playing an engaging video game. The purpose of this study was to determine the feasibility of using the Kinect platform to assess upper extremity function in individuals with dystrophinopathy across the spectrum of abilities. Investigators developed a proof-of-concept device, ACTIVE (Abilities Captured Through Interactive Video Evaluation), to measure functional reaching volume, movement velocity, and rate of fatigue. Five subjects with dystrophinopathy and 5 normal controls were tested using ACTIVE during one testing session. A single subject with dystrophinopathy was simultaneously tested with ACTIVE and a marker-based motion analysis system to establish preliminary validity of measurements. ACTIVE proof-of-concept ranked the upper extremity abilities of subjects with dystrophinopathy by Brooke score, and also differentiated them from performance of normal controls for the functional reaching volume and velocity tests. Preliminary test-retest reliability of the ACTIVE for 2 sequential trials was excellent for functional reaching volume (ICC=0.986, p<0.001) and velocity trials (ICC=0.963, p<0.001). The data from our pilot study with ACTIVE proof-of-concept demonstrates that newly available gaming technology has potential to be used to create a low-cost, widely-accessible and functional upper extremity outcome measure for use with children and adults with dystrophinopathy.

Investigating Extreme Heat and Humidity in the Northeast United States from a Joint Hazard Perspective

NASA Astrophysics Data System (ADS)

Horton, R. M.; Coffel, E.; Kushnir, Y.

2014-12-01

Recent years have seen an increasing focus on extreme high temperature events, as our understanding of societal vulnerability to such extremes has grown. Less climate research has been devoted to heat indices that consider the joint hazard posed by high temperatures and high humidity, even though heat indices are being prioritized by utility providers and public health officials. This paper evaluates how well CMIP5 models are able to reproduce the large-scale features and surface conditions associated with joint high heat and humidity events in the Northeast U.S. Projected changes in heat indices are also shown both for the full set of CMIP5 models and for a subset of models that best reproduce the statistics of historical high heat index events. The importance of considering the relationship between 1) temperature and humidity extremes and 2) projected changes in extreme temperature and humidity extremes, rather than investigating each variable independently, will be emphasized. Potential impacts of the findings on human mortality and energy consumption will be briefly discussed.

Chemistry integrated circuit: chemical system on a complementary metal oxide semiconductor integrated circuit.

PubMed

Nakazato, Kazuo

2014-03-28

By integrating chemical reactions on a large-scale integration (LSI) chip, new types of device can be created. For biomedical applications, monolithically integrated sensor arrays for potentiometric, amperometric and impedimetric sensing of biomolecules have been developed. The potentiometric sensor array detects pH and redox reaction as a statistical distribution of fluctuations in time and space. For the amperometric sensor array, a microelectrode structure for measuring multiple currents at high speed has been proposed. The impedimetric sensor array is designed to measure impedance up to 10 MHz. The multimodal sensor array will enable synthetic analysis and make it possible to standardize biosensor chips. Another approach is to create new functional devices by integrating molecular systems with LSI chips, for example image sensors that incorporate biological materials with a sensor array. The quantum yield of the photoelectric conversion of photosynthesis is 100%, which is extremely difficult to achieve by artificial means. In a recently developed process, a molecular wire is plugged directly into a biological photosynthetic system to efficiently conduct electrons to a gold electrode. A single photon can be detected at room temperature using such a system combined with a molecular single-electron transistor.

Business model innovation in the water sector in developing countries.

PubMed

Gebauer, Heiko; Saul, Caroline Jennings

2014-08-01

Various technologies have been deployed in household devices or micro-water treatment plants for mitigating fluoride and arsenic, and thereby provide safe and affordable drinking water in low-income countries. While the technologies have improved considerably, organizations still face challenges in making them financially sustainable. Financial sustainability questions the business models behind these water technologies. This article makes three contributions to business models in the context of fluoride and arsenic mitigation. Firstly, we describe four business models: A) low-value devices given away to people living in extreme poverty, B) high-value devices sold to low-income customers, C) communities as beneficiaries of micro-water treatment plants and D) entrepreneurs as franchisees for selling water services and highlight the emergence of hybrid business models. Secondly, we show current business model innovations such as cost transparency & cost reductions, secured & extended water payments, business diversification and distribution channels. Thirdly, we describe skills and competencies as part of capacity building for creating even more business model innovations. Together, these three contributions will create more awareness of the role of business models in scaling-up water treatment technologies. Copyright © 2014 Elsevier B.V. All rights reserved.

Dislocation creation and void nucleation in FCC ductile metals under tensile loading: a general microscopic picture.

PubMed

Pang, Wei-Wei; Zhang, Ping; Zhang, Guang-Cai; Xu, Ai-Guo; Zhao, Xian-Geng

2014-11-10

Numerous theoretical and experimental efforts have been paid to describe and understand the dislocation and void nucleation processes that are fundamental for dynamic fracture modeling of strained metals. To date an essential physical picture on the self-organized atomic collective motions during dislocation creation, as well as the essential mechanisms for the void nucleation obscured by the extreme diversity in structural configurations around the void nucleation core, is still severely lacking in literature. Here, we depict the origin of dislocation creation and void nucleation during uniaxial high strain rate tensile processes in face-centered-cubic (FCC) ductile metals. We find that the dislocations are created through three distinguished stages: (i) Flattened octahedral structures (FOSs) are randomly activated by thermal fluctuations; (ii) The double-layer defect clusters are formed by self-organized stacking of FOSs on the close-packed plane; (iii) The stacking faults are formed and the Shockley partial dislocations are created from the double-layer defect clusters. Whereas, the void nucleation is shown to follow a two-stage description. We demonstrate that our findings on the origin of dislocation creation and void nucleation are universal for a variety of FCC ductile metals with low stacking fault energies.

Design by Prototype: Examples from the National Aeronautics and Space Administration

NASA Technical Reports Server (NTRS)

Mulenburg, Gerald M.; Gundo, Daniel P.

2002-01-01

This paper describes and provides exa.mples of a technique called Design-by-Prototype used in the development of research hardware at the National Aeronautics and Space Administration's (NASA) Ames Research Center. This is not a new idea. Artisans and great masters have used prototyping as a design technique for centuries. They created prototypes to try out their ideas before making the primary artifact they were planning. This abstract is itself a prototype for others to use in determining the value of the paper it describes. At the Ames Research Center Design-by-Prototype is used for developing unique, one-of-a-kind hardware for small, high-risk projects. The need tor this new/old process is the proliferation of computer "design tools" that can result in both excessive time expended in design, and a lack of imbedded reality in the final product. Despite creating beautiful three-dimensional models and detailed computer drawings that can consume hundreds of engineering hours, the resulting designs can be extremely difficult to make, requiring many changes that add to the cost and schedule. Much design time can be saved and expensive rework eliminated using Design-by-Prototype.

Breast Imaging in the Era of Big Data: Structured Reporting and Data Mining.

PubMed

Margolies, Laurie R; Pandey, Gaurav; Horowitz, Eliot R; Mendelson, David S

2016-02-01

The purpose of this article is to describe structured reporting and the development of large databases for use in data mining in breast imaging. The results of millions of breast imaging examinations are reported with structured tools based on the BI-RADS lexicon. Much of these data are stored in accessible media. Robust computing power creates great opportunity for data scientists and breast imagers to collaborate to improve breast cancer detection and optimize screening algorithms. Data mining can create knowledge, but the questions asked and their complexity require extremely powerful and agile databases. New data technologies can facilitate outcomes research and precision medicine.

Effects of Extreme Temperatures on Cause-Specific Cardiovascular Mortality in China

PubMed Central

Wang, Xuying; Li, Guoxing; Liu, Liqun; Westerdahl, Dane; Jin, Xiaobin; Pan, Xiaochuan

2015-01-01

Objective: Limited evidence is available for the effects of extreme temperatures on cause-specific cardiovascular mortality in China. Methods: We collected data from Beijing and Shanghai, China, during 2007–2009, including the daily mortality of cardiovascular disease, cerebrovascular disease, ischemic heart disease and hypertensive disease, as well as air pollution concentrations and weather conditions. We used Poisson regression with a distributed lag non-linear model to examine the effects of extremely high and low ambient temperatures on cause-specific cardiovascular mortality. Results: For all cause-specific cardiovascular mortality, Beijing had stronger cold and hot effects than those in Shanghai. The cold effects on cause-specific cardiovascular mortality reached the strongest at lag 0–27, while the hot effects reached the strongest at lag 0–14. The effects of extremely low and high temperatures differed by mortality types in the two cities. Hypertensive disease in Beijing was particularly susceptible to both extremely high and low temperatures; while for Shanghai, people with ischemic heart disease showed the greatest relative risk (RRs = 1.16, 95% CI: 1.03, 1.34) to extremely low temperature. Conclusion: People with hypertensive disease were particularly susceptible to extremely low and high temperatures in Beijing. People with ischemic heart disease in Shanghai showed greater susceptibility to extremely cold days. PMID:26703637

Effects of Extreme Temperatures on Cause-Specific Cardiovascular Mortality in China.

PubMed

Wang, Xuying; Li, Guoxing; Liu, Liqun; Westerdahl, Dane; Jin, Xiaobin; Pan, Xiaochuan

2015-12-21

Limited evidence is available for the effects of extreme temperatures on cause-specific cardiovascular mortality in China. We collected data from Beijing and Shanghai, China, during 2007-2009, including the daily mortality of cardiovascular disease, cerebrovascular disease, ischemic heart disease and hypertensive disease, as well as air pollution concentrations and weather conditions. We used Poisson regression with a distributed lag non-linear model to examine the effects of extremely high and low ambient temperatures on cause-specific cardiovascular mortality. For all cause-specific cardiovascular mortality, Beijing had stronger cold and hot effects than those in Shanghai. The cold effects on cause-specific cardiovascular mortality reached the strongest at lag 0-27, while the hot effects reached the strongest at lag 0-14. The effects of extremely low and high temperatures differed by mortality types in the two cities. Hypertensive disease in Beijing was particularly susceptible to both extremely high and low temperatures; while for Shanghai, people with ischemic heart disease showed the greatest relative risk (RRs = 1.16, 95% CI: 1.03, 1.34) to extremely low temperature. People with hypertensive disease were particularly susceptible to extremely low and high temperatures in Beijing. People with ischemic heart disease in Shanghai showed greater susceptibility to extremely cold days.

Use of a Temporary Shunt as a Salvage Technique for Distal Extremity Amputations Requiring Repair by Vessel Grafting during Critical Ischemia

PubMed Central

Dadaci, Mehmet; Altuntas, Zeynep

2016-01-01

Background Although the use of temporary shunts in proximal extremity amputations has been reported, no study has described the use of temporary shunts in distal extremity amputations that require vein grafting. Moreover, the total volume of blood loss when temporary shunts are used has not been reported. The aim of this study was to investigate the applicability of a temporary shunt for distal extremity amputations requiring repair by vessel grafting with an ischemia time of >6 hours. This study also aimed to determine the total volume of blood loss when temporary shunts were used. Methods Patients who underwent distal major extremity replantation and/or revascularization with a vessel graft and who experienced ischemia for 6–8 hours between 2013 and 2014 were included in the study. A 6-Fr suction catheter was cut to 5 cm in length after the infusion of heparin, and secured with a 5-0 silk suture between the distal and the proximal ends of the artery. While bleeding continued, the bones were shortened and fixed. After the complete restoration of circulation, the arterial shunt created using the catheter was also repaired with a vein graft. Results Six patients were included in this study. The mean duration of ischemia was 7.25 hours. The mean duration of suction catheter use during limb revascularization was 7 minutes. The mean transfusion volume was 7.5 units. No losses of the extremity were observed. Conclusions This procedure should be considered in distal extremity amputations requiring repair by vessel grafting during critical ischemia. PMID:27896186

Measurements of the optical performance of bolometers for SPICA/SAFARI

NASA Astrophysics Data System (ADS)

Audley, Michael D.; de Lange, Gert; Gao, Jian-Rong; Khosropanah, Pourya; Ridder, Marcel; Ferrari, Lorenza; Laauwen, Wouter M.; Ranjan, Manisha; Mauskopf, Philip D.; Morozov, Dmitry; Trappe, Neil A.

2012-09-01

We have measured the optical response of detectors designed for SAFARI, the far-infrared imaging spectrometer for the SPICA satellite. To take advantage of SPICA's cooled optics, SAFARI’s three bolometer arrays are populated with extremely sensitive (NEP~2×10-19 W/√Hz) transition edge sensors with a transition temperature close to 100 mK. The extreme sensitivity and low saturation power (~4 fW) of SAFARI’s detectors present challenges to characterizing them. We have therefore built up an ultra-low background test facility with a cryogen-free high-capacity dilution refrigerator, paying careful attention to stray-light exclusion. Our use of a pulse-tube cooler to pre-cool the dilution refrigerator required that the SAFARI Detector System Test Facility provide a high degree electrical, magnetic, and mechanical isolation for the detectors. We have carefully characterized the performance of the test facility in terms of background power loading. The test facility has been designed to be flexible and easily reconfigurable with internal illuminators that allow us to characterize the optical response of the detectors. We describe the test facility and some of the steps we took to create an ultra-low background test environment. We have measured the optical response of two detectors designed for SAFARI’s short-wave wavelength band in combination with a spherical backshort and conical feedhorn. We find an overall optical efficiency of 40% for both, compared with an ideal-case predicted optical efficiency of 66%.

State-of-the-art Nanofabrication in Catalysis.

PubMed

Karim, Waiz; Tschupp, Simon A; Herranz, Juan; Schmidt, Thomas J; Ekinci, Yasin; van Bokhovenac, Jeroen A

2017-04-26

We present recent developments in top-down nanofabrication that have found application in catalysis research. To unravel the complexity of catalytic systems, the design and use of models with control of size, morphology, shape and inter-particle distances is a necessity. The study of well-defined and ordered nanoparticles on a support contributes to the understanding of complex phenomena that govern reactions in heterogeneous and electro-catalysis. We review the strengths and limitations of different nanolithography methods such as electron beam lithography (EBL), photolithography, extreme ultraviolet (EUV) lithography and colloidal lithography for the creation of such highly tunable catalytic model systems and their applications in catalysis. Innovative strategies have enabled particle sizes reaching dimensions below 10 nm. It is now possible to create pairs of particles with distance controlled with an extremely high precision in the order of one nanometer. We discuss our approach to study these model systems at the single-particle level using X-ray absorption spectroscopy and show new ways to fabricate arrays of single nanoparticles or nanoparticles in pairs over a large area using EBL and EUV-achromatic Talbot lithography. These advancements have provided new insights into the active sites in metal catalysts and enhanced the understanding of the role of inter-particle interactions and catalyst supports, such as in the phenomenon of hydrogen spillover. We present a perspective on future directions for employing top-down nanofabrication in heterogeneous and electrocatalysis. The rapid development in nanofabrication and characterization methods will continue to have an impact on understanding of complex catalytic processes.

A web-based study of bipolarity and impulsivity in athletes engaging in extreme and high-risk sports.

PubMed

Dudek, Dominika; Siwek, Marcin; Jaeschke, Rafał; Drozdowicz, Katarzyna; Styczeń, Krzysztof; Arciszewska, Aleksandra; Chrobak, Adrian A; Rybakowski, Janusz K

2016-06-01

We hypothesised that men and women who engage in extreme or high-risk sports would score higher on standardised measures of bipolarity and impulsivity compared to age and gender matched controls. Four-hundred and eighty extreme or high-risk athletes (255 males and 225 females) and 235 age-matched control persons (107 males and 128 females) were enrolled into the web-based case-control study. The Mood Disorder Questionnaire (MDQ) and Barratt Impulsiveness Scale (BIS-11) were administered to screen for bipolarity and impulsive behaviours, respectively. Results indicated that extreme or high-risk athletes had significantly higher scores of bipolarity and impulsivity, and lower scores on cognitive complexity of the BIS-11, compared to controls. Further, there were positive correlations between the MDQ and BIS-11 scores. These results showed greater rates of bipolarity and impulsivity, in the extreme or high-risk athletes, suggesting these measures are sensitive to high-risk behaviours.

The Convergence of High Performance Computing and Large Scale Data Analytics

NASA Astrophysics Data System (ADS)

Duffy, D.; Bowen, M. K.; Thompson, J. H.; Yang, C. P.; Hu, F.; Wills, B.

2015-12-01

As the combinations of remote sensing observations and model outputs have grown, scientists are increasingly burdened with both the necessity and complexity of large-scale data analysis. Scientists are increasingly applying traditional high performance computing (HPC) solutions to solve their "Big Data" problems. While this approach has the benefit of limiting data movement, the HPC system is not optimized to run analytics, which can create problems that permeate throughout the HPC environment. To solve these issues and to alleviate some of the strain on the HPC environment, the NASA Center for Climate Simulation (NCCS) has created the Advanced Data Analytics Platform (ADAPT), which combines both HPC and cloud technologies to create an agile system designed for analytics. Large, commonly used data sets are stored in this system in a write once/read many file system, such as Landsat, MODIS, MERRA, and NGA. High performance virtual machines are deployed and scaled according to the individual scientist's requirements specifically for data analysis. On the software side, the NCCS and GMU are working with emerging commercial technologies and applying them to structured, binary scientific data in order to expose the data in new ways. Native NetCDF data is being stored within a Hadoop Distributed File System (HDFS) enabling storage-proximal processing through MapReduce while continuing to provide accessibility of the data to traditional applications. Once the data is stored within HDFS, an additional indexing scheme is built on top of the data and placed into a relational database. This spatiotemporal index enables extremely fast mappings of queries to data locations to dramatically speed up analytics. These are some of the first steps toward a single unified platform that optimizes for both HPC and large-scale data analysis, and this presentation will elucidate the resulting and necessary exascale architectures required for future systems.

An adaptive metamaterial beam with hybrid shunting circuits for extremely broadband control of flexural wave (Conference Presentation)

NASA Astrophysics Data System (ADS)

Chen, Yangyang; Huang, Guoliang

2017-04-01

A great deal of research has been devoted to controlling the dynamic behaviors of phononic crystals and metamaterials by directly tuning the frequency regions and/or widths of their inherent band gaps. Here, we present a novel approach to achieve extremely broadband flexural wave/vibration attenuation based on tunable local resonators made of piezoelectric stacks shunted by hybrid negative capacitance and negative inductance circuits with proof masses attached on a host beam. First, wave dispersion relations of the adaptive metamaterial beam are calculated analytically by using the transfer matrix method. The unique modulus tuning properties induced by the hybrid shunting circuits are then characterized conceptually, from which the frequency dependent modulus tuning curves of the piezoelectric stack located within wave attenuation frequency regions are quantitatively identified. As an example, a flexural wave high-pass band filter with a wave attenuation region from 0 to 23.0 kHz is demonstrated analytically and numerically by using the hybrid shunting circuit, in which the two electric components are connected in series. By changing the connection pattern to be parallel, another super wide wave attenuation region from 13.5 to 73.0 kHz is demonstrated to function as a low-pass filter at a subwavelength scale. The proposed adaptive metamaterial possesses a super wide band gap created both naturally and artificially. Therefore, it can be used for the transient wave mitigation at extremely broadband frequencies such as blast or impact loadings. We envision that the proposed design and approach can open many possibilities in broadband vibration and wave control.

The combined risk of extreme tropical cyclone winds and storm surges along the U.S. Gulf of Mexico Coast

NASA Astrophysics Data System (ADS)

Trepanier, J. C.; Yuan, J.; Jagger, T. H.

2017-03-01

Tropical cyclones, with their nearshore high wind speeds and deep storm surges, frequently strike the United States Gulf of Mexico coastline influencing millions of people and disrupting offshore economic activities. The combined risk of occurrence of tropical cyclone nearshore wind speeds and storm surges is assessed at 22 coastal cities throughout the United States Gulf of Mexico. The models used are extreme value copulas fitted with margins defined by the generalized Pareto distribution or combinations of Weibull, gamma, lognormal, or normal distributions. The statistical relationships between the nearshore wind speed and storm surge are provided for each coastal city prior to the copula model runs using Spearman's rank correlations. The strongest significant relationship between the nearshore wind speed and storm surge exists at Shell Beach, LA (ρ = 0.67), followed by South Padre Island, TX (ρ = 0.64). The extreme value Archimedean copula models for each city then provide return periods for specific nearshore wind speed and storm surge pairs. Of the 22 cities considered, Bay St. Louis, MS, has the shortest return period for a tropical cyclone with at least a 50 ms-1 nearshore wind speed and a 3 m surge (19.5 years, 17.1-23.5). The 90% confidence intervals are created by recalculating the return periods for a fixed set of wind speeds and surge levels using 100 samples of the model parameters. The results of this study can be utilized by policy managers and government officials concerned with coastal populations and economic activity in the Gulf of Mexico.

Statistical uncertainty of extreme wind storms over Europe derived from a probabilistic clustering technique

NASA Astrophysics Data System (ADS)

Walz, Michael; Leckebusch, Gregor C.

2016-04-01

Extratropical wind storms pose one of the most dangerous and loss intensive natural hazards for Europe. However, due to only 50 years of high quality observational data, it is difficult to assess the statistical uncertainty of these sparse events just based on observations. Over the last decade seasonal ensemble forecasts have become indispensable in quantifying the uncertainty of weather prediction on seasonal timescales. In this study seasonal forecasts are used in a climatological context: By making use of the up to 51 ensemble members, a broad and physically consistent statistical base can be created. This base can then be used to assess the statistical uncertainty of extreme wind storm occurrence more accurately. In order to determine the statistical uncertainty of storms with different paths of progression, a probabilistic clustering approach using regression mixture models is used to objectively assign storm tracks (either based on core pressure or on extreme wind speeds) to different clusters. The advantage of this technique is that the entire lifetime of a storm is considered for the clustering algorithm. Quadratic curves are found to describe the storm tracks most accurately. Three main clusters (diagonal, horizontal or vertical progression of the storm track) can be identified, each of which have their own particulate features. Basic storm features like average velocity and duration are calculated and compared for each cluster. The main benefit of this clustering technique, however, is to evaluate if the clusters show different degrees of uncertainty, e.g. more (less) spread for tracks approaching Europe horizontally (diagonally). This statistical uncertainty is compared for different seasonal forecast products.

Under-reported dosimetry errors due to interplay effects during VMAT dose delivery in extreme hypofractionated stereotactic radiotherapy.

PubMed

Gauer, Tobias; Sothmann, Thilo; Blanck, Oliver; Petersen, Cordula; Werner, René

2018-06-01

Radiotherapy of extracranial metastases changed from normofractioned 3D CRT to extreme hypofractionated stereotactic treatment using VMAT beam techniques. Random interaction between tumour motion and dynamically changing beam parameters might result in underdosage of the CTV even for an appropriately dimensioned ITV (interplay effect). This study presents a clinical scenario of extreme hypofractionated stereotactic treatment and analyses the impact of interplay effects on CTV dose coverage. For a thoracic/abdominal phantom with an integrated high-resolution detector array placed on a 4D motion platform, dual-arc treatment plans with homogenous target coverage were created using a common VMAT technique and delivered in a single fraction. CTV underdosage through interplay effects was investigated by comparing dose measurements with and without tumour motion during plan delivery. Our study agrees with previous works that pointed out insignificant interplay effects on target coverage for very regular tumour motion patterns like simple sinusoidal motion. However, we identified and illustrated scenarios that are likely to result in a clinically relevant CTV underdosage. For tumour motion with abnormal variability, target coverage quantified by the CTV area receiving more than 98% of the prescribed dose decreased to 78% compared to 100% at static dose measurement. This study is further proof of considerable influence of interplay effects on VMAT dose delivery in stereotactic radiotherapy. For selected conditions of an exemplary scenario, interplay effects and related motion-induced target underdosage primarily occurred in tumour motion pattern with increased motion variability and VMAT plan delivery using complex MLC dose modulation.

Spring Break versus Spring Broken: Predictive Utility of Spring Break Alcohol Intentions and Willingness at Varying Levels of Extremity

PubMed Central

Litt, Dana M.; Lewis, Melissa A.; Patrick, Megan E.; Rodriguez, Lindsey; Neighbors, Clayton; Kaysen, Debra L.

2013-01-01

Objective Within the domain of risk-related behavior, many times the decision to engage is not a product of premeditation or intention. The Prototype Willingness model was created to capture and explain the unintended element of risk behavior. The present study aimed to evaluate the importance of willingness versus intention, two important constructs within the Prototype Willingness model, in relation to Spring Break drinking behavior when assessed at both high and low extremities. Method College undergraduates (N = 275) completed questionnaires prior to Spring Break regarding their anticipated Spring Break activities. Willingness and intention were assessed for different levels of risk. Specifically, participants indicated the extent to which they intended to (a) get drunk and (b) drink enough to black out or pass out; and the extent to which they were willing to (a) get drunk and (b) drink enough to black out or pass out. When classes resumed following Spring Break, the students indicated the extent to which they actually (a) got drunk and (b) drank enough to black out or pass out. Results Results demonstrated that when the health-related risk was lower (i.e., getting drunk), intention was a stronger predictor of behavior than was willingness. However, as the level of risk increased (i.e., getting drunk enough to black out or pass out), willingness more strongly predicted behavior. Conclusion The present study suggests that willingness and intentions differentially predict Spring Break alcohol-related behavior depending on the extremity of behavior in question. Implications regarding alcohol interventions are discussed. PMID:23404667

Two Strategies for Microbial Production of an Industrial Enzyme-Alpha-Amylase

NASA Technical Reports Server (NTRS)

Bernhardsdotter, Eva C. M. J.; Garriott, Owen; Pusey, Marc L.; Ng, Joseph D.

2003-01-01

Extremophiles are microorganisms that thrive in, from an anthropocentric view, extreme environments including hot springs, soda lakes and arctic water. This ability of survival at extreme conditions has rendered extremophiles to be of interest in astrobiology, evolutionary biology as well as in industrial applications. Of particular interest to the biotechnology industry are the biological catalysts of the extremophiles, the extremozymes, whose unique stabilities at extreme conditions make them potential sources of novel enzymes in industrial applications. There are two major approaches to microbial enzyme production. This entails enzyme isolation directly from the natural host or creating a recombinant expression system whereby the targeted enzyme can be overexpressed in a mesophilic host. We are employing both methods in the effort to produce alpha-amylases from a hyperthermophilic archaeon (Thermococcus) isolated from a hydrothermal vent in the Atlantic Ocean, as well as from alkaliphilic bacteria (Bacillus) isolated from a soda lake in Tanzania. Alpha-amylases catalyze the hydrolysis of internal alpha-1,4-glycosidic linkages in starch to produce smaller sugars. Thermostable alpha-amylases are used in the liquefaction of starch for production of fructose and glucose syrups, whereas alpha-amylases stable at high pH have potential as detergent additives. The alpha-amylase encoding gene from Thermococcus was PCR amplified using carefully designed primers and analyzed using bioinformatics tools such as BLAST and Multiple Sequence Alignment for cloning and expression in E.coli. Four strains of Bacillus were grown in alkaline starch-enriched medium of which the culture supernatant was used as enzyme source. Amylolytic activity was detected using the starch-iodine method.

Asynchronous Messaging and Data Transfer in a Spacecraft: An Implementation

NASA Technical Reports Server (NTRS)

Moholt, Joseph M.

2005-01-01

Data transfer and messaging is an important part of a spacecraft. Creating a standard protocol for messaging that can be used for a variety of applications is an extremely beneficial project at the Jet Propulsion Laboratory (JPL). The Asynchronous Messaging Service (AMS) is a protocol outlining how subsystems initialize and conduct communication between each other. There are currently two implementations of AMS in the works. At JPL, my task is to get a working implementation of AMS onto vxWorks as a proof of concept. An Autocoder, a program used to convert visually created state chart diagrams to C++, has also been created to accomplish a part of the implementation. I was assigned to make the program portable on any Unix type environment. Lastly, I was to develop a program to demonstrate messaging between two FireWire cards running vxworks.

A sutureless technique using cyanoacrylate adhesives when creating a stoma for extremely low birth weight infants.

PubMed

Nose, Satoko; Sasaki, Takashi; Saka, Ryuta; Minagawa, Kyoko; Okuyama, Hiroomi

2016-01-01

Intestinal perforation and necrotizing enterocolitis (NEC) are neonatal intestinal emergencies that are especially common in premature infants. While prompt surgical intervention, including stoma creation, is often required, the optimal surgical treatment has been controversial because of the substantial risks related to the stoma creation and management. The use of a tissue adhesive may have some advantages over the use of sutures when creating an intestinal stoma in extremely low birth weight (ELBW) infants. The purpose of this report was to present a novel approach for creating a stoma using a tissue adhesive in ELBW infants. A total of eight ELBW infants that underwent laparotomy with the creation of intestinal stomas using cyanoacrylate adhesive at our institution between 2009 and 2014 were enrolled. The clinical parameters, including the length of the operation, intra- and postoperative complications and the outcomes were evaluated. The median body weight and gestational age at birth were 630 g and 24.3 weeks, respectively. The median age at referral was 11.5 days. The median length of the procedure was 58.5 min, including the inspection and resection of the intestine. All procedures were completed without any intraoperative complications. There were no postoperative complications associated with the stoma. Two patients died of the associated septic status. Sutureless enterostomy using cyanoacrylate adhesive is a simple technique which has the potential to reduce the incidence of complications related to the intestinal stoma in ELBW infants.

Adaptation potential of naturally ventilated barns to high temperature extremes: The OptiBarn project

NASA Astrophysics Data System (ADS)

Menz, Christoph

2016-04-01

Climate change interferes with various aspects of the socio-economic system. One important aspect is its influence on animal husbandry, especially dairy faming. Dairy cows are usually kept in naturally ventilated barns (NVBs) which are particular vulnerable to extreme events due to their low adaptation capabilities. An effective adaptation to high outdoor temperatures for example, is only possible under certain wind and humidity conditions. High temperature extremes are expected to increase in number and strength under climate change. To assess the impact of this change on NVBs and dairy cows also the changes in wind and humidity needs to be considered. Hence we need to consider the multivariate structure of future temperature extremes. The OptiBarn project aims to develop sustainable adaptation strategies for dairy housings under climate change for Europe, by considering the multivariate structure of high temperature extremes. In a first step we identify various multivariate high temperature extremes for three core regions in Europe. With respect to dairy cows in NVBs we will focus on the wind and humidity field during high temperature events. In a second step we will use the CORDEX-EUR-11 ensemble to evaluate the capability of the RCMs to model such events and assess their future change potential. By transferring the outdoor conditions to indoor climate and animal wellbeing the results of this assessment can be used to develop technical, architectural and animal specific adaptation strategies for high temperature extremes.

Differential Resonant Ring YIG Tuned Oscillator

NASA Technical Reports Server (NTRS)

Parrott, Ronald A.

2010-01-01

A differential SiGe oscillator circuit uses a resonant ring-oscillator topology in order to electronically tune the oscillator over multi-octave bandwidths. The oscillator s tuning is extremely linear, because the oscillator s frequency depends on the magnetic tuning of a YIG sphere, whose resonant frequency is equal to a fundamental constant times the DC magnetic field. This extremely simple circuit topology uses two coupling loops connecting a differential pair of SiGe bipolar transistors into a feedback configuration using a YIG tuned filter creating a closed-loop ring oscillator. SiGe device technology is used for this oscillator in order to keep the transistor s 1/f noise to an absolute minimum in order to achieve minimum RF phase noise. The single-end resonant ring oscillator currently has an advantage in fewer parts, but when the oscillation frequency is greater than 16 GHz, the package s parasitic behavior couples energy to the sphere and causes holes and poor phase noise performance. This is because the coupling to the YIG is extremely low, so that the oscillator operates at near the unloaded Q. With the differential resonant ring oscillator, the oscillation currents are just in the YIG coupling mechanisms. The phase noise is even better, and the physical size can be reduced to permit monolithic microwave integrated circuit oscillators. This invention is a YIG tuned oscillator circuit making use of a differential topology to simultaneously achieve an extremely broadband electronic tuning range and ultra-low phase noise. As a natural result of its differential circuit topology, all reactive elements, such as tuning stubs, which limit tuning bandwidth by contributing excessive open loop phase shift, have been eliminated. The differential oscillator s open-loop phase shift is associated with completely non-dispersive circuit elements such as the physical angle of the coupling loops, a differential loop crossover, and the high-frequency phase shift of the n-p-n transistors. At the input of the oscillator s feedback loop is a pair of differentially connected n-p-n SiGe transistors that provides extremely high gain, and because they are bulk-effect devices, extremely low 1/f noise (leading to ultralow RF phase noise). The 1/f corner frequency for n-p-n SiGe transistors is approximately 500 Hz. The RF energy from the transistor s collector output is connected directly to the top-coupling loop (the excitation loop) of a single-sphere YIG tuned filter. A uniform magnetic field to bias the YIG must be at a right angle to any vector associated with an RF current in a coupling loop in order for the precession to interact with the RF currents.

Climate Resiliency Planning: Making Extreme Event Science Useful for Managers and Planners in Northern Nevada

NASA Astrophysics Data System (ADS)

McCarthy, M.; Kenneston, A.; Wall, T. U.; Brown, T. J.; Redmond, K. T.

2014-12-01

Effective climate resiliency planning at the regional level requires extensive interactive dialogue among climate scientists, emergency managers, public health officials, urban planners, social scientists, and policy makers. Engaging federal, tribal, state, local governments and private sector business and infrastructure owners/operators in defining, assessing and characterizing the impacts of extreme events allows communities to understand how different events "break the system" forcing local communities to seek support and resources from state/federal governments and/or the private sector and what actions can be taken proactively to mitigate consequences and accelerate recovery. The Washoe County Regional Resiliency Study was prepared in response to potential climate variability related impacts specific to the Northern Nevada Region. The last several decades have seen dramatic growth in the region, coupled with increased resource demands that have forced local governments to consider how those impacts will affect the region and may, in turn, impact the region's ability to provide essential services. The Western Regional Climate Center of the Desert Research Institute provided a synthesis of climate studies with predictions regarding plausible changes in the local climate of Northern California and Nevada for the next 50 years. In general, these predictions indicate that the region's climate is undergoing a gradual shift, which will primarily affect the frequency, amount, and form of precipitation in the Sierra Nevada and Great Basin. Changes in water availability and other extreme events may have serious and long lasting effects in the Northern Nevada Region, and create a variety of social, environmental and economic concerns. A range of extreme events were considered including Adverse Air Quality, Droughts, Floods, Heat Waves, High Wind, Structure Fires, Wildland Fires, and Major Winter Storms. Due to the complexity of our climate systems, and the difficulty in specifying how severe the climate effects may be or how those impacts compound existing hazards in the system, the Resiliency Study focused on identifying a variety of 'no regrets' policy options that can help the local communities anticipate, respond and recover faster and more efficiently to climate extremes.

The nonstationary impact of local temperature changes and ENSO on extreme precipitation at the global scale

NASA Astrophysics Data System (ADS)

Sun, Qiaohong; Miao, Chiyuan; Qiao, Yuanyuan; Duan, Qingyun

2017-12-01

The El Niño-Southern Oscillation (ENSO) and local temperature are important drivers of extreme precipitation. Understanding the impact of ENSO and temperature on the risk of extreme precipitation over global land will provide a foundation for risk assessment and climate-adaptive design of infrastructure in a changing climate. In this study, nonstationary generalized extreme value distributions were used to model extreme precipitation over global land for the period 1979-2015, with ENSO indicator and temperature as covariates. Risk factors were estimated to quantify the contrast between the influence of different ENSO phases and temperature. The results show that extreme precipitation is dominated by ENSO over 22% of global land and by temperature over 26% of global land. With a warming climate, the risk of high-intensity daily extreme precipitation increases at high latitudes but decreases in tropical regions. For ENSO, large parts of North America, southern South America, and southeastern and northeastern China are shown to suffer greater risk in El Niño years, with more than double the chance of intense extreme precipitation in El Niño years compared with La Niña years. Moreover, regions with more intense precipitation are more sensitive to ENSO. Global climate models were used to investigate the changing relationship between extreme precipitation and the covariates. The risk of extreme, high-intensity precipitation increases across high latitudes of the Northern Hemisphere but decreases in middle and lower latitudes under a warming climate scenario, and will likely trigger increases in severe flooding and droughts across the globe. However, there is some uncertainties associated with the influence of ENSO on predictions of future extreme precipitation, with the spatial extent and risk varying among the different models.

Not all droughts are created equal: the impacts of interannual drought pattern and magnitude on grassland carbon cycling.

PubMed

Hoover, David L; Rogers, Brendan M

2016-05-01

Climate extremes, such as drought, may have immediate and potentially prolonged effects on carbon cycling. Grasslands store approximately one-third of all terrestrial carbon and may become carbon sources during droughts. However, the magnitude and duration of drought-induced disruptions to the carbon cycle, as well as the mechanisms responsible, remain poorly understood. Over the next century, global climate models predict an increase in two types of drought: chronic but subtle 'press-droughts', and shorter term but extreme 'pulse-droughts'. Much of our current understanding of the ecological impacts of drought comes from experimental rainfall manipulations. These studies have been highly valuable, but are often short term and rarely quantify carbon feedbacks. To address this knowledge gap, we used the Community Land Model 4.0 to examine the individual and interactive effects of pulse- and press-droughts on carbon cycling in a mesic grassland of the US Great Plains. A series of modeling experiments were imposed by varying drought magnitude (precipitation amount) and interannual pattern (press- vs. pulse-droughts) to examine the effects on carbon storage and cycling at annual to century timescales. We present three main findings. First, a single-year pulse-drought had immediate and prolonged effects on carbon storage due to differential sensitivities of ecosystem respiration and gross primary production. Second, short-term pulse-droughts caused greater carbon loss than chronic press-droughts when total precipitation reductions over a 20-year period were equivalent. Third, combining pulse- and press-droughts had intermediate effects on carbon loss compared to the independent drought types, except at high drought levels. Overall, these results suggest that interannual drought pattern may be as important for carbon dynamics as drought magnitude and that extreme droughts may have long-lasting carbon feedbacks in grassland ecosystems. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

Microbial diversity of extreme habitats in human homes.

PubMed

Savage, Amy M; Hills, Justin; Driscoll, Katherine; Fergus, Daniel J; Grunden, Amy M; Dunn, Robert R

2016-01-01

High-throughput sequencing techniques have opened up the world of microbial diversity to scientists, and a flurry of studies in the most remote and extreme habitats on earth have begun to elucidate the key roles of microbes in ecosystems with extreme conditions. These same environmental extremes can also be found closer to humans, even in our homes. Here, we used high-throughput sequencing techniques to assess bacterial and archaeal diversity in the extreme environments inside human homes (e.g., dishwashers, hot water heaters, washing machine bleach reservoirs, etc.). We focused on habitats in the home with extreme temperature, pH, and chemical environmental conditions. We found a lower diversity of microbes in these extreme home environments compared to less extreme habitats in the home. However, we were nonetheless able to detect sequences from a relatively diverse array of bacteria and archaea. Habitats with extreme temperatures alone appeared to be able to support a greater diversity of microbes than habitats with extreme pH or extreme chemical environments alone. Microbial diversity was lowest when habitats had both extreme temperature and one of these other extremes. In habitats with both extreme temperatures and extreme pH, taxa with known associations with extreme conditions dominated. Our findings highlight the importance of examining interactive effects of multiple environmental extremes on microbial communities. Inasmuch as taxa from extreme environments can be both beneficial and harmful to humans, our findings also suggest future work to understand both the threats and opportunities posed by the life in these habitats.

Suppression of the Rayleigh Taylor instability and its implication for the impact ignition

NASA Astrophysics Data System (ADS)

Azechi, H.; Shiraga, H.; Nakai, M.; Shigemori, K.; Fujioka, S.; Sakaiya, T.; Tamari, Y.; Ohtani, K.; Murakami, M.; Sunahara, A.; Nagatomo, H.; Nishihara, K.; Miyanaga, N.; Izawa, Y.

2004-12-01

The Rayleigh Taylor (RT) instability with material ablation through an unstable interface is the key physics that determines the success or failure of inertial fusion energy (IFE) generation, as the RT instability potentially quenches ignition and burn by disintegrating the IFE target. We present two suppression schemes of the RT growth without significant degradation of the target density. The first scheme is to generate a double ablation structure in high-Z doped plastic targets. In addition to the electron ablation surface, a new ablation surface is created by x-ray radiation from the high-Z ions. Contrary to the previous thought, the electron ablation surface is almost completely stabilized by extremely high flow velocity. On the other hand, the RT instability on the radiative ablation surface is significantly moderated. The second is to enhance the nonlocal nature of the electron heat transport by illuminating the target with long wavelength laser light, whereas the high ablation pressure is generated by irradiating with short wavelength laser light. The significant suppression of the RT instability may increase the possibility of impact ignition which uses a high-velocity fuel colliding with a preformed main fuel.

[Role of hemoglobin affinity to oxygen in adaptation to hypoxemia].

PubMed

Kwasiborski, Przemysław Jerzy; Kowalczyk, Paweł; Zieliński, Jakub; Przybylski, Jacek; Cwetsch, Andrzej

2010-04-01

One of the basic mechanisms of adapting to hypoxemia is a decrease in the affinity of hemoglobin for oxygen. This process occurs mainly due to the increased synthesis of 2,3-diphosphoglycerate (2,3-DPG) in the erythrocytes, as well as through the Bohr effect. Hemoglobin with decreased affinity for oxygen increases the oxygenation of tissues, because it gives up oxygen more easily during microcirculation. In foetal circulation, however, at a partial oxygen pressure (pO2) of 25 mmHg in the umbilical vein, the oxygen carrier is type F hemoglobin which has a high oxygen affinity. The commonly accepted role for hemoglobin F is limited to facilitating diffusion through the placenta. Is fetal life the only moment when haemoglobin F is useful? THE AIM OF STUDY was to create a mathematical model, which would answer the question at what conditions an increase, rather than a decrease, in haemoglobin oxygen affinity is of benefit to the body. Using the kinetics of dissociation of oxygen from hemoglobin described by the Hill equation as the basis for further discussion, we created a mathematical model describing the pO2 value in the microcirculatory system and its dependence on arterial blood pO2. The calculations were performed for hemoglobin with low oxygen affinity (adult type) and high-affinity hemoglobin (fetal type). The modelling took into account both physiological and pathological ranges of acid-base equilibrium and tissue oxygen extraction parameters. It was shown that for the physiological range of acid-base equilibrium and the resting level of tissue oxygen extraction parameters, with an arterial blood pO2 of 26.8 mmHg, the higher-affinity hemoglobin becomes the more effective oxygen carrier. It was also demonstrated that the arterial blood pO2, below which the high-affinity hemoglobin becomes the more effective carrier, is dependent on blood pH and the difference between the arterial and venous oxygen saturation levels. Simulations performed for the pathological states showed that acidosis and increased tissue oxygen demand lead to a broadened arterial blood pO2 range, in which the high-affinity hemoglobin is more efficient. Contrary to the widely held view that the only response to hypoxemia is a decrease in haemoglobin oxygen affinity, it was shown that under extreme hypoxemic conditions, an increased haemoglobin oxygen affinity improves the oxygenation of tissues. It was also shown that the dominance of hemoglobin with a high oxygen affinity rapidly exceeds hemoglobin with low oxygen affinity in the case of acidosis with its accompanying high tissue oxygen extraction. In cases of extreme disruptions of the acid-base equilibrium, the dominance of high-oxygen-affinity hemoglobin spans over the entire possible range of pO2 in arterial blood.

The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

ScienceCinema

Mao, Ho-kwang (Director, Center for Energy Frontier Research in Extreme Environments); EFree Staff

2017-12-09

'The Behavior of Hydrogen Under Extreme Conditions on Ultrafast Timescales ' was submitted by the Center for Energy Frontier Research in Extreme Environments (EFree) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. EFree is directed by Ho-kwang Mao at the Carnegie Institute of Washington and is a partnership of scientists from thirteen institutions.The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges. The mission of Energy Frontier Research in Extreme Environments is 'to accelerate the discovery and creation of energy-relevant materials using extreme pressures and temperatures.' Research topics are: catalysis (CO{sub 2}, water), photocatalysis, solid state lighting, optics, thermelectric, phonons, thermal conductivity, solar electrodes, fuel cells, superconductivity, extreme environment, radiation effects, defects, spin dynamics, CO{sub 2} (capture, convert, store), greenhouse gas, hydrogen (fuel, storage), ultrafast physics, novel materials synthesis, and defect tolerant materials.

Mechanical characterization of alloys in extreme conditions of high strain rates and high temperature

NASA Astrophysics Data System (ADS)

Cadoni, Ezio

2018-03-01

The aim of this paper is the description of the mechanical characterization of alloys under extreme conditions of temperature and loading. In fact, in the frame of the Cost Action CA15102 “Solutions for Critical Raw Materials Under Extreme Conditions (CRM-EXTREME)” this aspect is crucial and many industrial applications have to consider the dynamic response of materials. Indeed, for a reduction and substitution of CRMs in alloys is necessary to design the materials and understand if the new materials behave better or if the substitution or reduction badly affect their performance. For this reason, a deep knowledge of the mechanical behaviour at high strain-rates of considered materials is required. In general, machinery manufacturing industry or transport industry as well as energy industry have important dynamic phenomena that are simultaneously affected by extended strain, high strain-rate, damage and pressure, as well as conspicuous temperature gradients. The experimental results in extreme conditions of high strain rate and high temperature of an austenitic stainless steel as well as a high-chromium tempered martensitic reduced activation steel Eurofer97 are presented.

Spectroscopic Investigations of Highly Charged Tungsten Ions - Atomic Spectroscopy and Fusion Plasma Diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clementson, Joel

2010-05-01

The spectra of highly charged tungsten ions have been investigated using x-ray and extreme ultraviolet spectroscopy. These heavy ions are of interest in relativistic atomic structure theory, where high-precision wavelength measurements benchmark theoretical approaches, and in magnetic fusion research, where the ions may serve to diagnose high-temperature plasmas. The work details spectroscopic investigations of highly charged tungsten ions measured at the Livermore electron beam ion trap (EBIT) facility. Here, the EBIT-I and SuperEBIT electron beam ion traps have been employed to create, trap, and excite tungsten ions of M- and L-shell charge states. The emitted spectra have been studied inmore » high resolution using crystal, grating, and x-ray calorimeter spectrometers. In particular, wavelengths of n = 0 M-shell transitions in K-like W 55+ through Ne-like W 64+, and intershell transitions in Zn-like W 44+ through Co-like W 47+ have been measured. Special attention is given to the Ni-like W46+ ion, which has two strong electric-dipole forbidden transitions that are of interest for plasma diagnostics. The EBIT measurements are complemented by spectral modeling using the Flexible Atomic Code (FAC), and predictions for tokamak spectra are presented. The L-shell tungsten ions have been studied at electron-beam energies of up to 122 keV and transition energies measured in Ne-like W 64+ through Li-like W 71+. These spectra constitute the physics basis in the design of the ion-temperature crystal spectrometer for the ITER tokamak. Tungsten particles have furthermore been introduced into the Sustained Spheromak Physics Experiment (SSPX) spheromak in Livermore in order to investigate diagnostic possibilities of extreme ultraviolet tungsten spectra for the ITER divertor. The spheromak measurement and spectral modeling using FAC suggest that tungsten ions in charge states around Er-like W 6+ could be useful for plasma diagnostics.« less

Using EPA Tools and Data Services to Inform Changes to Design Storm Definitions for Wastewater Utilities based on Climate Model Projections

NASA Astrophysics Data System (ADS)

Tryby, M.; Fries, J. S.; Baranowski, C.

2014-12-01

Extreme precipitation events can cause significant impacts to drinking water and wastewater utilities, including facility damage, water quality impacts, service interruptions and potential risks to human health and the environment due to localized flooding and combined sewer overflows (CSOs). These impacts will become more pronounced with the projected increases in frequency and intensity of extreme precipitation events due to climate change. To model the impacts of extreme precipitation events, wastewater utilities often develop Intensity, Duration, and Frequency (IDF) rainfall curves and "design storms" for use in the U.S. Environmental Protection Agency's (EPA) Storm Water Management Model (SWMM). Wastewater utilities use SWMM for planning, analysis, and facility design related to stormwater runoff, combined and sanitary sewers, and other drainage systems in urban and non-urban areas. SWMM tracks (1) the quantity and quality of runoff made within each sub-catchment; and (2) the flow rate, flow depth, and quality of water in each pipe and channel during a simulation period made up of multiple time steps. In its current format, EPA SWMM does not consider climate change projection data. Climate change may affect the relationship between intensity, duration, and frequency described by past rainfall events. Therefore, EPA is integrating climate projection data available in the Climate Resilience Evaluation and Awareness Tool (CREAT) into SWMM. CREAT is a climate risk assessment tool for utilities that provides downscaled climate change projection data for changes in the amount of rainfall in a 24-hour period for various extreme precipitation events (e.g., from 5-year to 100-year storm events). Incorporating climate change projections into SWMM will provide wastewater utilities with more comprehensive data they can use in planning for future storm events, thereby reducing the impacts to the utility and customers served from flooding and stormwater issues.

Ion cyclotron emission studies: Retrospects and prospects

DOE PAGES

Gorelenkov, N. N.

2016-06-05

Ion cyclotron emission (ICE) studies emerged in part from the papers by A.B. Mikhailovskii published in the 1970s. Among the discussed subjects were electromagnetic compressional Alfv,nic cyclotron instabilities with the linear growth rate similar ~ √(n α/n e) driven by fusion products, -particles which draw a lot of attention to energetic particle physics. The theory of ICE excited by energetic particles was significantly advanced at the end of the 20th century motivated by first DT experiments on TFTR and subsequent JET experimental studies which we highlight. Recently ICE theory was advanced by detailed theoretical and experimental studies on spherical torusmore » (ST) fusion devices where the instability signals previously indistinguishable in high aspect ratio tokamaks due to high toroidal magnetic field became the subjects of experiments. Finally, we discuss prospects of ICE theory applications for future burning plasma (BP) experiments such as those to be conducted in ITER device in France, where neutron and gamma rays escaping the plasma create extremely challenging conditions fusion alpha particle diagnostics.« less

Massively parallel de novo protein design for targeted therapeutics.

PubMed

Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J; Hicks, Derrick R; Vergara, Renan; Murapa, Patience; Bernard, Steffen M; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T; Koday, Merika T; Jenkins, Cody M; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M; Fernández-Velasco, D Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A; Fuller, Deborah H; Baker, David

2017-10-05

De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

Achieving a 100% Renewable Grid: Operating Electric Power Systems with Extremely High Levels of Variable Renewable Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kroposki, Benjamin; Johnson, Brian; Zhang, Yingchen

What does it mean to achieve a 100% renewable grid? Several countries already meet or come close to achieving this goal. Iceland, for example, supplies 100% of its electricity needs with either geothermal or hydropower. Other countries that have electric grids with high fractions of renewables based on hydropower include Norway (97%), Costa Rica (93%), Brazil (76%), and Canada (62%). Hydropower plants have been used for decades to create a relatively inexpensive, renewable form of energy, but these systems are limited by natural rainfall and geographic topology. Around the world, most good sites for large hydropower resources have already beenmore » developed. So how do other areas achieve 100% renewable grids? Variable renewable energy (VRE), such as wind and solar photovoltaic (PV) systems, will be a major contributor, and with the reduction in costs for these technologies during the last five years, large-scale deployments are happening around the world.« less

Investigation of ELF/VLF waves created by a "beat-wave" HF ionospheric heating at high latitudes

NASA Astrophysics Data System (ADS)

Shumilov, Oleg; Tereshchenko, Evgeniy; Kasatkina, Elena; Gomonov, Alexandr

2015-04-01

The generation of extremely low frequency (ELF, 3-3000 Hz) and very low frequency (VLF, 3-30 kHz) electromagnetic waves by modulated ionospheric high frequency (HF, 2-30 MHz) heating is one of the main directions of ionospheric modification experiments. In this work, we present observations of ELF waves generated during a "beat-wave" heating experiments at the EISCAT heating facility. ELF waves were registered with the ELF receiver located at Lovozero (68 N, 35 E), 660 km east from the EISCAT Tromso heating facility (69.6 N, 19.2 E). Frequency shifts between the generated beat-wave and received ELF waves were detected in all sessions. It is shown that the amplitudes of ELF waves depend on the auroral electrojet current strength. Our results showing a strong dependence of ELF signal intensities on the substorm development seem to support the conclusion that electrojet currents may affect the BW generation of ELF/VLF waves.

Massively parallel de novo protein design for targeted therapeutics

NASA Astrophysics Data System (ADS)

Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J.; Hicks, Derrick R.; Vergara, Renan; Murapa, Patience; Bernard, Steffen M.; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D.; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T.; Koday, Merika T.; Jenkins, Cody M.; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M.; Fernández-Velasco, D. Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A.; Fuller, Deborah H.; Baker, David

2017-10-01

De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37-43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing.

Cosmological quantum chromodynamics, neutron diffusion, and the production of primordial heavy elements

NASA Technical Reports Server (NTRS)

Applegate, J. H.; Hogan, Craig J.; Scherrer, R. J.

1988-01-01

A simple one-dimensional model is used to describe the evolution of neutron density before and during nucleosynthesis in a high-entropy bubble left over from the cosmic quark-hadron phase transition. It is shown why cosmic nucleosynthesis in such a neutron-rich environment produces a surfeit of elements heavier than lithium. Analytical and numerical techniques are used to estimate the abundances of carbon, nitrogen, and heavier elements up to Ne-22. A high-density neutron-rich region produces enough primordial N-14 to be observed in stellar atmospheres. It shown that very heavy elements may be created in a cosmological r-process; the neutron exposure in the neutron-rich regions is large enough for the Ne-22 to trigger a catastrophic r-process runaway in which the quantity of heavy elements doubles in much less than an expansion time due to fission cycling. A primordial abundance of r-process elements is predicted to appear as an excess of rare earth elements in extremely metal-poor stars.

Effects of hypoxia caused by mussel farming on benthic foraminifera in semi-closed Gamak Bay, South Korea.

PubMed

Lee, Yeon Gyu; Jeong, Da Un; Lee, Jung Sick; Choi, Yang Ho; Lee, Moon Ok

2016-08-15

Seawater monitoring and geochemical and benthic foraminiferal analysis of sediments were conducted to identify the effects of hypoxia created by a mussel farm on benthic foraminifera in a semi-closed bay. Extremely polluted reductive conditions with a high content of organic matter (OM) at >12.0% and oxygen minimum zones (OMZs) with dissolved oxygen (DO) <0.4mg∙L(-1) were formed below the mussel farm in the northwest area of Gamak Bay, and gradually diffused toward the south. Highly similar patterns of variation were observed in species diversity, abundance frequency, and benthic foraminiferal assemblage distributed from Elphidium subarcticum-Ammonia beccarii in the northwest area through E. subarcticum-A. beccarii-Trochammina hadai, E. subarcticum-A. beccarii-Elphidiumclavatum, and E. clavatum-Ammonia ketienziensis in the southern area. These phenomena were caused by hydrodynamics in the current water mass. It was thought that E. subarcticum is a bioindicator of organic pollution caused by the mussel farm. Copyright © 2016 Elsevier Ltd. All rights reserved.

Causality of an extreme harmful algal bloom in Monterey Bay, California, during the 2014-2016 northeast Pacific warm anomaly

NASA Astrophysics Data System (ADS)

Ryan, J. P.; Kudela, R. M.; Birch, J. M.; Blum, M.; Bowers, H. A.; Chavez, F. P.; Doucette, G. J.; Hayashi, K.; Marin, R.; Mikulski, C. M.; Pennington, J. T.; Scholin, C. A.; Smith, G. J.; Woods, A.; Zhang, Y.

2017-06-01

An ecologically and economically disruptive harmful algal bloom (HAB) affected much of the northeast Pacific margin in 2015, during a prolonged oceanic warm anomaly. Caused by diatoms of the genus Pseudo-nitzschia, this HAB produced the highest particulate concentrations of the biotoxin domoic acid (DA) ever recorded in Monterey Bay, California. Bloom inception followed strong upwelling during the spring transition, which introduced nutrients and eliminated the warm anomaly locally. Subsequently, moderate and intermittent upwelling created favorable conditions for growth and accumulation of HAB biomass, which was dominated by a highly toxigenic species, P. australis. High cellular DA concentrations were associated with available nitrogen for DA synthesis coincident with silicate exhaustion. This nutrient influence resulted from two factors: (1) disproportionate depletion of silicate in upwelling source waters during the warm anomaly, the most severe depletion observed in 24 years, and (2) silicate uptake by the dense diatom bloom.

Massively parallel de novo protein design for targeted therapeutics

PubMed Central

Chevalier, Aaron; Silva, Daniel-Adriano; Rocklin, Gabriel J.; Hicks, Derrick R.; Vergara, Renan; Murapa, Patience; Bernard, Steffen M.; Zhang, Lu; Lam, Kwok-Ho; Yao, Guorui; Bahl, Christopher D.; Miyashita, Shin-Ichiro; Goreshnik, Inna; Fuller, James T.; Koday, Merika T.; Jenkins, Cody M.; Colvin, Tom; Carter, Lauren; Bohn, Alan; Bryan, Cassie M.; Fernández-Velasco, D. Alejandro; Stewart, Lance; Dong, Min; Huang, Xuhui; Jin, Rongsheng; Wilson, Ian A.; Fuller, Deborah H.; Baker, David

2018-01-01

De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthesis, yeast display screening and next-generation sequencing. We designed and tested 22,660 mini-proteins of 37–43 residues that target influenza haemagglutinin and botulinum neurotoxin B, along with 6,286 control sequences to probe contributions to folding and binding, and identified 2,618 high-affinity binders. Comparison of the binding and non-binding design sets, which are two orders of magnitude larger than any previously investigated, enabled the evaluation and improvement of the computational model. Biophysical characterization of a subset of the binder designs showed that they are extremely stable and, unlike antibodies, do not lose activity after exposure to high temperatures. The designs elicit little or no immune response and provide potent prophylactic and therapeutic protection against influenza, even after extensive repeated dosing. PMID:28953867

Acquisition and Processing of High Resolution Hyperspectral Imageries for the 3d Mapping of Urban Heat Islands and Microparticles of Montreal

NASA Astrophysics Data System (ADS)

Mongeau, R.; Baudouin, Y.; Cavayas, F.

2017-10-01

Ville de Montreal wanted to develop a system to identify heat islands and microparticles at the urban scale and to study their formation. UQAM and UdeM universities have joined their expertise under the framework "Observatoire Spatial Urbain" to create a representative geospatial database of thermal and atmospheric parameters collected during the summer months. They innovated in the development of a methodology for processing high resolution hyperspectral images (1-2 m). In partnership with Ville de Montreal, they integrated 3D geospatial data (topography, transportation and meteorology) in the process. The 3D mapping of intraurban heat islands as well as air micro-particles makes it possible, initially, to identify the problematic situations for future civil protection interventions during extreme heat. Moreover, it will be used as a reference for the Ville de Montreal to establish a strategy for public domain tree planting and in the analysis of urban development projects.

Ion cyclotron emission studies: Retrospects and prospects

NASA Astrophysics Data System (ADS)

Gorelenkov, N. N.

2016-05-01

Ion cyclotron emission (ICE) studies emerged in part from the papers by A.B. Mikhailovskii published in the 1970s. Among the discussed subjects were electromagnetic compressional Alfvénic cyclotron instabilities with the linear growth rate √ {n_α /n_e } driven by fusion products, -particles which draw a lot of attention to energetic particle physics. The theory of ICE excited by energetic particles was significantly advanced at the end of the 20th century motivated by first DT experiments on TFTR and subsequent JET experimental studies which we highlight. More recently ICE theory was advanced by detailed theoretical and experimental studies on spherical torus (ST) fusion devices where the instability signals previously indistinguishable in high aspect ratio tokamaks due to high toroidal magnetic field became the subjects of experiments. We discuss further prospects of ICE theory applications for future burning plasma (BP) experiments such as those to be conducted in ITER device in France, where neutron and gamma rays escaping the plasma create extremely challenging conditions fusion alpha particle diagnostics.

Alpha: A real-time decentralized operating system for mission-oriented system integration and operation

NASA Technical Reports Server (NTRS)

Jensen, E. Douglas

1988-01-01

Alpha is a new kind of operating system that is unique in two highly significant ways. First, it is decentralized transparently providing reliable resource management across physically dispersed nodes, so that distributed applications programming can be done largely as though it were centralized. And second, it provides comprehensive, high technology support for real-time system integration and operation, an application area which consists predominately of aperiodic activities having critical time constraints such as deadlines. Alpha is extremely adaptable so that it can be easily optimized for a wide range of problem-specific functionality, performance, and cost. Alpha is the first systems effort of the Archons Project, and the prototype was created at Carnegie-Mellon University directly on modified Sun multiprocessor workstation hardware. It has been demonstrated with a real-time C(sup 2) application. Continuing research is leading to a series of enhanced follow-ons to Alpha; these are portable but initially hosted on Concurrent's MASSCOMP line of multiprocessor products.

QSRA: a quality-value guided de novo short read assembler.

PubMed

Bryant, Douglas W; Wong, Weng-Keen; Mockler, Todd C

2009-02-24

New rapid high-throughput sequencing technologies have sparked the creation of a new class of assembler. Since all high-throughput sequencing platforms incorporate errors in their output, short-read assemblers must be designed to account for this error while utilizing all available data. We have designed and implemented an assembler, Quality-value guided Short Read Assembler, created to take advantage of quality-value scores as a further method of dealing with error. Compared to previous published algorithms, our assembler shows significant improvements not only in speed but also in output quality. QSRA generally produced the highest genomic coverage, while being faster than VCAKE. QSRA is extremely competitive in its longest contig and N50/N80 contig lengths, producing results of similar quality to those of EDENA and VELVET. QSRA provides a step closer to the goal of de novo assembly of complex genomes, improving upon the original VCAKE algorithm by not only drastically reducing runtimes but also increasing the viability of the assembly algorithm through further error handling capabilities.

New biodegradable dextran-based hydrogels for protein delivery: Synthesis and characterization.

PubMed

Pacelli, Settimio; Paolicelli, Patrizia; Casadei, Maria Antonietta

2015-08-01

A new derivative of dextran grafted with polyethylene glycol methacrylate through a carbonate bond (DEX-PEG-MA) has been synthesized and characterized. The photo-crosslinking reaction of DEX-PEG-MA allowed the obtainment of biodegradable networks tested for their mechanical and release properties. The new hydrogels were compared with those made of dextran methacrylate (DEX-MA), often employed as drug delivery systems of small molecules. The inclusion of PEG as a spacer created additional interactions among the polymeric chains improving the extreme fragility and lack of hardness typical of gels made of DEX-MA. Moreover, the different behavior in terms of swelling and degradability of the networks was able to affect the release of a model macromolecule over time, making DEX-PEG-MA matrices suitable candidates for the delivery of high molecular weight peptides. Interestingly, the combination of the two dextran derivatives showed intermediate ability to modulate the release of high molecular weight macromolecules. Copyright © 2015 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, Gangjian; Shi, Fengyuan; Hao, Shiqiang

The broad-based implementation of thermoelectric materials in converting heat to electricity hinges on the achievement of high conversion efficiency. Here we demonstrate a thermoelectric figure of merit ZT of 2.5 at 923 K by the cumulative integration of several performance-enhancing concepts in a single material system. Using non-equilibrium processing we show that hole-doped samples of PbTe can be heavily alloyed with SrTe well beyond its thermodynamic solubility limit of <1 mol%. The much higher levels of Sr alloyed into the PbTe matrix widen the bandgap and create convergence of the two valence bands of PbTe, greatly boosting the power factorsmore » with maximal values over 30 μWcm -1 K -2. Exceeding the 5 mol% solubility limit leads to endotaxial SrTe nanostructures which produce extremely low lattice thermal conductivity of 0.5 Wm -1 K -1 but preserve high hole mobilities because of the matrix/precipitate valence band alignment. The best composition is hole-doped PbTe-8% SrTe.« less

Comparing postdeposition reactions of electrons and radicals with Pt nanostructures created by focused electron beam induced deposition.

PubMed

Spencer, Julie A; Barclay, Michael; Gallagher, Miranda J; Winkler, Robert; Unlu, Ilyas; Wu, Yung-Chien; Plank, Harald; McElwee-White, Lisa; Fairbrother, D Howard

2017-01-01

The ability of electrons and atomic hydrogen (AH) to remove residual chlorine from PtCl 2 deposits created from cis -Pt(CO) 2 Cl 2 by focused electron beam induced deposition (FEBID) is evaluated. Auger electron spectroscopy (AES) and energy-dispersive X-ray spectroscopy (EDS) measurements as well as thermodynamics calculations support the idea that electrons can remove chlorine from PtCl 2 structures via an electron-stimulated desorption (ESD) process. It was found that the effectiveness of electrons to purify deposits greater than a few nanometers in height is compromised by the limited escape depth of the chloride ions generated in the purification step. In contrast, chlorine atoms can be efficiently and completely removed from PtCl 2 deposits using AH, regardless of the thickness of the deposit. Although AH was found to be extremely effective at chemically purifying PtCl 2 deposits, its viability as a FEBID purification strategy is compromised by the mobility of transient Pt-H species formed during the purification process. Scanning electron microscopy data show that this results in the formation of porous structures and can even cause the deposit to lose structural integrity. However, this phenomenon suggests that the use of AH may be a useful strategy to create high surface area Pt catalysts and may reverse the effects of sintering. In marked contrast to the effect observed with AH, densification of the structure was observed during the postdeposition purification of PtC x deposits created from MeCpPtMe 3 using atomic oxygen (AO), although the limited penetration depth of AO restricts its effectiveness as a purification strategy to relatively small nanostructures.

Comparing postdeposition reactions of electrons and radicals with Pt nanostructures created by focused electron beam induced deposition

PubMed Central

Spencer, Julie A; Barclay, Michael; Gallagher, Miranda J; Winkler, Robert; Unlu, Ilyas; Wu, Yung-Chien; Plank, Harald; McElwee-White, Lisa

2017-01-01

The ability of electrons and atomic hydrogen (AH) to remove residual chlorine from PtCl2 deposits created from cis-Pt(CO)2Cl2 by focused electron beam induced deposition (FEBID) is evaluated. Auger electron spectroscopy (AES) and energy-dispersive X-ray spectroscopy (EDS) measurements as well as thermodynamics calculations support the idea that electrons can remove chlorine from PtCl2 structures via an electron-stimulated desorption (ESD) process. It was found that the effectiveness of electrons to purify deposits greater than a few nanometers in height is compromised by the limited escape depth of the chloride ions generated in the purification step. In contrast, chlorine atoms can be efficiently and completely removed from PtCl2 deposits using AH, regardless of the thickness of the deposit. Although AH was found to be extremely effective at chemically purifying PtCl2 deposits, its viability as a FEBID purification strategy is compromised by the mobility of transient Pt–H species formed during the purification process. Scanning electron microscopy data show that this results in the formation of porous structures and can even cause the deposit to lose structural integrity. However, this phenomenon suggests that the use of AH may be a useful strategy to create high surface area Pt catalysts and may reverse the effects of sintering. In marked contrast to the effect observed with AH, densification of the structure was observed during the postdeposition purification of PtCx deposits created from MeCpPtMe3 using atomic oxygen (AO), although the limited penetration depth of AO restricts its effectiveness as a purification strategy to relatively small nanostructures. PMID:29234576

Counter-Discursive and Erotic Agency: The Case of the Black Slaves in Miguel De Cervantes's "El Celoso Extremeño"

ERIC Educational Resources Information Center

Ruiz, Eduardo

2014-01-01

Cervantes's "novela" creates a complex protagonist due in part to the involvement of the slaves' destructive and creative energies: a linguistic and erotic paradox. Linguistically the female slave foregrounds the historical dichotomy between "ladinos" and "bozales" and the related problematic of conversion,…

An Automated System for Generating Situation-Specific Decision Support in Clinical Order Entry from Local Empirical Data

ERIC Educational Resources Information Center

Klann, Jeffrey G.

2011-01-01

Clinical Decision Support is one of the only aspects of health information technology that has demonstrated decreased costs and increased quality in healthcare delivery, yet it is extremely expensive and time-consuming to create, maintain, and localize. Consequently, a majority of health care systems do not utilize it, and even when it is…

Migrant and Seasonal Head Start Participants, Programs, Families and Staff in 2013

ERIC Educational Resources Information Center

Schmit, Stephanie

2014-01-01

Migrant and Seasonal Head Start (MSHS) was created to respond to the needs of migrant farm worker families. MSHS provides child care services to migrants to ensure that young children are not with their parents in the fields, where they can be exposed to pesticides, hazardous equipment, extreme heat, and other health dangers. MSHS has served…

77 FR 30581 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

..., and in fact may create investor confusion about the extent of trading interest in a stock. In extreme... orders at different price levels to move the price of a stock. While Phlx has an active program to detect... market manipulation. The fee will be imposed on market participant identifiers (``MPID'') that have...

The N of 1 in Arts-Based Research: Reliability and Validity

ERIC Educational Resources Information Center

Siegesmund, Richard

2014-01-01

N signifies the number of data samples in a study. Traditional research values numerous data samples as this reduces the variability created by extremes. Alternatively, arts-based research privileges the outlier, the N of 1. Oftentimes, what is unique and outside the norm is the focus. There are three approaches to the N of 1 in arts-based…

Radiometer on a Chip

NASA Technical Reports Server (NTRS)

Chattopadhyay, Goutam; Gill, John J.; Mehdi, Imran; Lee, Choonsup; Schlecht, Erich T.; Skalare, Anders; Ward, John S.; Siegel, Peter H.; Thomas, Bertrand C.

2009-01-01

The radiometer on a chip (ROC) integrates whole wafers together to p rovide a robust, extremely powerful way of making submillimeter rece ivers that provide vertically integrated functionality. By integratin g at the wafer level, customizing the interconnects, and planarizing the transmission media, it is possible to create a lightweight asse mbly performing the function of several pieces in a more conventiona l radiometer.

Challenges Raising a Gifted Child: Stress and Resilience Factors within the Family

ERIC Educational Resources Information Center

Renati, Roberta; Bonfiglio, Natale Salvatore; Pfeiffer, Steven

2017-01-01

The research on families of the gifted is extremely limited. In the past, families of the gifted have been studied mainly for two reasons: to discover how family life creates or supports giftedness or eminence, or to understand how one gifted child affects siblings. Few studies, however, have examined the impact of gifted children on the lives of…

Heavy Drinking on College Campuses: No Reason to Change Minimum Legal Drinking Age of 21

ERIC Educational Resources Information Center

Saylor, Drew K.

2011-01-01

The recent Amethyst Initiative argues that a minimum legal drinking age (MLDA) of 21 has created a culture of heavy alcohol use on college campuses by making drinking clandestine and extreme. This group and others argue that lowering the MLDA will reduce the problem of "binge drinking" on college campuses. However, such a policy change would…

Comparative analysis of low-back loading on chiropractors using various workstation table heights and performing various tasks.

PubMed

Lorme, Kenneth J; Naqvi, Syed A

2003-01-01

There is epidemiologic evidence that chiropractors are a high-risk group for low-back disorders. However, to date there are no known biomechanical studies to determine whether their workstations may be a contributing factor. To investigate whether chiropractors' workstation table height or the tasks they perform make them susceptible to low-back strain. As well as investigating low-back strain, a screening was performed to determine whether chiropractors' upper extremities were at risk for undue strain as workstation table height was varied. Experimental pilot study. A university ergonomic laboratory. An adjustable manipulation table was set at 3 different heights: 465 mm, 665 mm and 845 mm. Each of the 7 volunteer chiropractors were fitted with a triaxial electrogoniometer and were videotaped and photographed for analysis while performing spinal manipulation to the cervical, thoracic, and lumbar spine of a volunteer patient at each workstation table height. Two biomechanical models, one static and one dynamic, were used to record the dependent variables. A screening of various upper extremity variables was also performed with the static model. For the subjects under study, a significant difference was found for the variables maximum sagittal flexion, disk compression force, and ligament strain as table height was varied. For the lumbar and thoracic manipulation tasks, the medium table height (655 mm) was found to create the least low-back strain. For the cervical manipulation task, the high table height (845 mm) was found to be the least straining on the low-back. The low height table (465 mm) was the most straining for all tasks. Upper extremities were not significantly affected by changes to table height. Significant differences were found for the task performed for axial rotational velocity, disk compression force, ligament strain, maximum sagittal flexion, dominant (right) elbow moment, and dominant (right) shoulder moment variables. There was no significant interaction between table height and task performed. Workstation table height was found to have a significant effect on low-back load of subjects under study. The results of this study demonstrate an overall unacceptably high amount of sagittal flexion, ligament strain, and disk compression force on the chiropractor subjects in the tasks performed.

Mladotice Lake, Czechia: The unique genesis and evolution of the lake basin

NASA Astrophysics Data System (ADS)

Janský, Bohumír; Šobr, Miroslav; Kliment, Zdeněk; Chalupová, Dagmar

2016-04-01

The Mladotice Lake is a lake of unique genetic type in Czechia. In May 1872 a landslide as a result an extreme rainfall event occurred in western Czechia, blocking the Mladoticky stream valley and creating the Mladotice Lake. The 1952 and 1975 air images document that collective farming had a great impact on the lake basin evolution when balks and field terraces were removed and fields were made much larger. Because of this change in land use we expected higher soil erosion and a related increase in the sedimentation rate. First bathymetric measurements of the newly created lake were carried out in 1972 and were repeated in 1999, in 2003 and in 2014. Our analysis of the sedimentary record aims to identify the sediment stratigraphy, its basic physical and chemical properties, isotope content and thin sections yield a detailed temporal resolution of the sedimentation chronology. In some areas a sediment thickness of 4 m was detected. Hence, the average sedimentation rate is from 2.2 to 2.7 cm per year. KEY WORDS: Mladotice Lake - extreme rainfall event - landslide - land use changes - flood events - bathymetric measurements - sedimentation dynamics - stratigraphy and geochemistry of lake sediments - analyses of isotopes - sedimentation rates.

Restructuring Big Data to Improve Data Access and Performance in Analytic Services Making Research More Efficient for the Study of Extreme Weather Events and Application User Communities

NASA Astrophysics Data System (ADS)

Ostrenga, D.; Shen, S.; Vollmer, B.; Meyer, D. L.

2017-12-01

NASA climate reanalysis dataset from MERRA-2 contains numerous data for atmosphere, land, and ocean, that are grouped into 95 products of archived volume over 300 TB. The data files are saved as hourly-file, day-file (hourly time interval) and month-file containing up to 125 parameters. Due to the large number of data files and the sheer data volumes, it is a challenging for users, especially those in the application research community, to handle dealing with the original data files. Most of these researchers prefer to focus on a small region or single location using the hourly data for long time periods to analyze extreme weather events or say winds for renewable energy applications. At the GES DISC, we have been working closely with the science teams and the application user community to create several new value added data products and high quality services to facilitate the use of the model data for various types of research. We have tested converting hourly data from one-day per file into different data cubes, such as one-month, one-year, or whole-mission and then continued to analyze the efficiency of the accessibility of this newly structured data through various services. Initial results have shown that compared to the original file structure, the new data has significantly improved the performance for accessing long time series. It is noticed that the performance is associated to the cube size and structure, the compression method, and how the data are accessed. The optimized data cube structure will not only improve the data access, but also enable better online analytic services for doing statistical analysis and extreme events mining. Two case studies will be presented using the newly structured data and value added services, the California drought and the extreme drought of the Northeastern states of Brazil. Furthermore, data access and analysis through cloud storage capabilities will be investigated.

Temperature and moisture conditions for life in the extreme arid region of the Atacama desert: four years of observations including the El Nino of 1997-1998

NASA Technical Reports Server (NTRS)

McKay, Christopher P.; Friedmann, E. Imre; Gomez-Silva, Benito; Caceres-Villanueva, Luis; Andersen, Dale T.; Landheim, Ragnhild

2003-01-01

The Atacama along the Pacific Coast of Chile and Peru is one of the driest and possibly oldest deserts in the world. It represents an extreme habitat for life on Earth and is an analog for life in dry conditions on Mars. We report on four years (September 1994-October 1998) of climate and moisture data from the extreme arid region of the Atacama. Our data are focused on understanding moisture sources and their role in creating suitable environments for photosynthetic microorganisms in the desert surface. The average air temperature was 16.5 degrees C and 16.6 degrees C in 1995 and 1996, respectively. The maximum air temperature recorded was 37.9 degrees C, and the minimum was -5.7 degrees C. Annual average sunlight was 336 and 335 W m(-2) in 1995 and 1996, respectively. Winds averaged a few meters per second, with strong fohn winds coming from the west exceeding 12 m s(-1). During our 4 years of observation there was only one significant rain event of 2.3 mm, which occurred near midnight local time. We suggest that this event was a rainout of a heavy fog. It is of interest that the strong El Nino of 1997-1998 brought heavy rainfall to the deserts of Peru, but did not bring significant rain to the central Atacama in Chile. Dew occurred at our station frequently following high nighttime relative humidity, but is not a significant source of moisture in the soil or under stones. Groundwater also does not contribute to surface moisture. Only the one rain event of 2.3 mm resulted in liquid water in the soil and beneath stones for a total of only 65-85 h over 4 years. The paucity of liquid water under stones is consistent with the apparent absence of hypolithic (under-stone) cyanobacteria, the only known primary producers in such extreme deserts.

Studying dynamic processes in liquids by TEM/STEM/DTEM

NASA Astrophysics Data System (ADS)

Abellan, Patricia; Evans, James; Woehl, Taylor; Jungjohann, Katherine; Parent, Lucas; Arslan, Ilke; Ristenpart, William; Browning, Nigel; Mater. Sci. Group Team; Microsc. Group Team; Catal. Sci. Group Collaboration; Ristenpart Res. Group Collaboration

2013-03-01

In order to study dynamic phenomena such as corrosion or catalysis, extreme environmental conditions must be reproduced around the specimen - these include high-temperatures, high-pressures, specific oxidizing/reducing atmospheres or a liquid environment. The use of environmental stages specifically designed to fit in any transmission electron microscope (TEM) allows us to apply the distinct capabilities of each instrument to study dynamic processes. Localized gas/fluid conditions are created around the sample and separated from the high vacuum inside the microscope using hermetically sealed windowed-cells. Advanced capabilities of these techniques include spatial resolutions of ~1 Angstrom or better in aberration corrected instruments or temporal resolutions in the microsecond-nanosecond range in a dynamic TEM (DTEM). Here, unique qualities of the DTEM that benefit the in-situ experiments with gas/fluid environmental cells will be discussed. We also present our results with a liquid stage allowing atomic resolution imaging of nanomaterials in a colloidal suspension, core EEL spectra acquisition, continuous flow, controlled growth of nanocrystals and systematic calibration of the effect of the electron dose on silver nuclei formation.

Non-equilibrium processing leads to record high thermoelectric figure of merit in PbTe–SrTe

DOE PAGES

Tan, Gangjian; Shi, Fengyuan; Hao, Shiqiang; ...

2016-07-26

The broad-based implementation of thermoelectric materials in converting heat to electricity hinges on the achievement of high conversion efficiency. Here we demonstrate a thermoelectric figure of merit ZT of 2.5 at 923 K by the cumulative integration of several performance-enhancing concepts in a single material system. Using non-equilibrium processing we show that hole-doped samples of PbTe can be heavily alloyed with SrTe well beyond its thermodynamic solubility limit of <1 mol%. The much higher levels of Sr alloyed into the PbTe matrix widen the bandgap and create convergence of the two valence bands of PbTe, greatly boosting the power factorsmore » with maximal values over 30 μWcm -1 K -2. Exceeding the 5 mol% solubility limit leads to endotaxial SrTe nanostructures which produce extremely low lattice thermal conductivity of 0.5 Wm -1 K -1 but preserve high hole mobilities because of the matrix/precipitate valence band alignment. The best composition is hole-doped PbTe-8% SrTe.« less

A highly fluorescent hydrophilic ionic liquid as a potential probe for the sensing of biomacromolecules.

PubMed

Chen, Xu-Wei; Liu, Jia-Wei; Wang, Jian-Hua

2011-02-17

With respect to the conventional imidazolium ionic liquids which generally create very weak fluorescence with quantum yields at extremely low levels of 0.005-0.02, a symmetrical hydrophilic ionic liquid 1,3-butylimidazolium chloride (BBimCl) was found to be highly fluorescent with λ(em) at 388 nm when excited at λ(ex) < 340 nm. The very high quantum yield of BBimCl in aqueous medium, derived to be 0.523 when excited at 315 nm, was attributed to its symmetrical plane conjugating structure. In the presence of hemoglobin, the fluorescence of BBimCl could be significantly quenched, resulting from the coordinating interaction between the iron atom in the heme group of hemoglobin and the cationic imidazolium moiety. This feature of the present hydrophilic ionic liquid makes it a promising fluorescence probe candidate for the sensitive sensing of hemoglobin. A linear regression was observed within 3 × 10(-7) to 5 × 10(-6) mol L(-1) for hemoglobin, and a detection limit of 7.3 × 10(-8) mol L(-1) was derived.

Non-equilibrium processing leads to record high thermoelectric figure of merit in PbTe–SrTe

PubMed Central

Tan, Gangjian; Shi, Fengyuan; Hao, Shiqiang; Zhao, Li-Dong; Chi, Hang; Zhang, Xiaomi; Uher, Ctirad; Wolverton, Chris; Dravid, Vinayak P.; Kanatzidis, Mercouri G.

2016-01-01

The broad-based implementation of thermoelectric materials in converting heat to electricity hinges on the achievement of high conversion efficiency. Here we demonstrate a thermoelectric figure of merit ZT of 2.5 at 923 K by the cumulative integration of several performance-enhancing concepts in a single material system. Using non-equilibrium processing we show that hole-doped samples of PbTe can be heavily alloyed with SrTe well beyond its thermodynamic solubility limit of <1 mol%. The much higher levels of Sr alloyed into the PbTe matrix widen the bandgap and create convergence of the two valence bands of PbTe, greatly boosting the power factors with maximal values over 30 μW cm−1 K−2. Exceeding the 5 mol% solubility limit leads to endotaxial SrTe nanostructures which produce extremely low lattice thermal conductivity of 0.5 W m−1 K−1 but preserve high hole mobilities because of the matrix/precipitate valence band alignment. The best composition is hole-doped PbTe–8%SrTe. PMID:27456303

Can an ankle-foot orthosis change hearts and minds?

PubMed

Patzkowski, Jeanne C; Blanck, Ryan V; Owens, Johnny G; Wilken, Jason M; Blair, James A; Hsu, Joseph R

2011-01-01

The current military conflicts of Operation Enduring Freedom and Operation Iraqi Freedom have been characterized by high-energy explosive wounding patterns, with the majority affecting the extremities. While many injuries have resulted in amputation, surgical advances have allowed the orthopaedic surgeon to pursue limb salvage in the face of injuries once considered unsalvageable. The military limb salvage patient is frequently highly active and motivated and expresses significant frustration with the slow nature of limb salvage rehabilitation and continued functional deficits. Inspired by these patients, efforts at this institution began to provide them with a more dynamic orthosis. Utilizing techniques and technology resulting from cerebral palsy, stroke, and amputation research, the Intrepid Dynamic Exoskeletal Orthosis was created. To date, this device has significantly improved the functional capabilities of the limb salvage wounded warrior population when combined with a high-intensity rehabilitation program. Clinical and biomechanical research is currently underway at this institution in order to fully characterize the device, its effect on patients, and what can be done to modify future generations of the device to best serve the combat-wounded limb salvage population.

Coupled field-structural analysis of HGTR fuel brick using ABAQUS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohanty, S.; Jain, R.; Majumdar, S.

2012-07-01

High-temperature, gas-cooled reactors (HTGRs) are usually helium-gas cooled, with a graphite core that can operate at reactor outlet temperatures much higher than can conventional light water reactors. In HTGRs, graphite components moderate and reflect neutrons. During reactor operation, high temperature and high irradiation cause damage to the graphite crystal and grains and create other defects. This cumulative structural damage during the reactor lifetime leads to changes in graphite properties, which can alter the ability to support the designed loads. The aim of the present research is to develop a finite-element code using commercially available ABAQUS software for the structural integritymore » analysis of graphite core components under extreme temperature and irradiation conditions. In addition, the Reactor Geometry Generator tool-kit, developed at Argonne National Laboratory, is used to generate finite-element mesh for complex geometries such as fuel bricks with multiple pin holes and coolant flow channels. This paper presents the proposed concept and discusses results of stress analysis simulations of a fuel block with H-451 grade material properties. (authors)« less

Minimal Prospects for Radio Detection of Extensive Air Showers in the Atmosphere of Jupiter

NASA Astrophysics Data System (ADS)

Bray, J. D.; Nelles, A.

2016-07-01

One possible approach for detecting ultra-high-energy cosmic rays and neutrinos is to search for radio emission from extensive air showers created when they interact in the atmosphere of Jupiter, effectively utilizing Jupiter as a particle detector. We investigate the potential of this approach. For searches with current or planned radio telescopes we find that the effective area for detection of cosmic rays is substantial (˜3 × 107 km2), but the acceptance angle is so small that the typical geometric aperture (˜103 km2 sr) is less than that of existing terrestrial detectors, and cosmic rays also cannot be detected below an extremely high threshold energy (˜1023 eV). The geometric aperture for neutrinos is slightly larger, and greater sensitivity can be achieved with a radio detector on a Jupiter-orbiting satellite, but in neither case is this sufficient to constitute a practical detection technique. Exploitation of the large surface area of Jupiter for detecting ultra-high-energy particles remains a long-term prospect that will require a different technique, such as orbital fluorescence detection.

High-Quality CrO2 Nanowires for Dissipation-less Spintronics

NASA Astrophysics Data System (ADS)

Singh, Amrita; Jansen, Charlotte; Lahabi, Kaveh; Aarts, Jan

2016-10-01

Superconductor-ferromagnet (S-F) hybrids based on half-metallic ferromagnets, such as CrO2 , are ideal candidates for superconducting spintronic applications. This is primarily due to the fully spin-polarized nature of CrO2 , which produces enhanced long-range triplet proximity effects. However, reliable production of CrO2 -based Josephson junctions (JJs) has proved to be extremely challenging because of a poorly controlled interface transparency and an incomplete knowledge of the local magnetization of the CrO2 films. To address these issues, we use a bottom-up approach to grow CrO2 nanowires on prepatterned substrates via chemical-vapor deposition. A comprehensive study of the growth mechanism enables us to reliably synthesize faceted, homogeneous CrO2 wires with a well-defined magnetization state. Combining these high-quality wires with a superconductor produces JJs with a high interface transparency, leading to exceptionally large 100% spin-polarized supercurrents, with critical current densities exceeding 109 Am-2 over distances as long as 600 nm. These CrO2 -nanowire-based JJs thus provide a realistic route to creating a scalable device platform for dissipation-less spintronics.

Trace elements in native and transplanted Fontinalis antipyretica and Platyhypnidium riparioides from rivers polluted by uranium mining.

PubMed

Kosior, Grzegorz; Steinnes, Eiliv; Samecka-Cymerman, Aleksandra; Lierhagen, Syverin; Kolon, Krzysztof; Dołhańczuk-Śródka, Agnieszka; Ziembik, Zbigniew

2017-03-01

The past uranium/polymetallic mining activities in the Sudety (SW Poland) left abandoned mines, pits, and dumps of waste rocks with trace elements and radionuclides which may erode or leach out and create a potential risk for the aquatic ecosystem, among others. In the present work four rivers affected by effluents from such mines were selected to evaluate the application of aquatic mosses for the bioindication of 56 elements. Naturally growing F. antipyretica and P. riparioides were compared with transplanted samples of the same species. The results demonstrate serious pollution of the examined rivers, especially with As, Ba, Fe, Mn, Pb, Ti, U and Zn, reaching extremely high concentrations in native moss samples. In the most polluted rivers native F. antipyretica and P. riparioides samples showed significantly higher concentrations of As, Ba, Cu, Fe, La, Nd, Ni, Pb, U and Zn than corresponding transplanted samples, whereas at less polluted sites a reverse situation was sometimes observed. Transplanted moss moved from clean to extremely polluted rivers probably protects itself against the accumulation of toxic elements by reducing their uptake. Selection of native or transplanted F. antipyretica and P. riparioides depended on the pollution load. Copyright © 2016. Published by Elsevier Ltd.

Source of the Kerr-Newman solution as a gravitating bag model: 50 years of the problem of the source of the Kerr solution

NASA Astrophysics Data System (ADS)

Burinskii, Alexander

2016-01-01

It is known that gravitational and electromagnetic fields of an electron are described by the ultra-extreme Kerr-Newman (KN) black hole solution with extremely high spin/mass ratio. This solution is singular and has a topological defect, the Kerr singular ring, which may be regularized by introducing the solitonic source based on the Higgs mechanism of symmetry breaking. The source represents a domain wall bubble interpolating between the flat region inside the bubble and external KN solution. It was shown recently that the source represents a supersymmetric bag model, and its structure is unambiguously determined by Bogomolnyi equations. The Dirac equation is embedded inside the bag consistently with twistor structure of the Kerr geometry, and acquires the mass from the Yukawa coupling with Higgs field. The KN bag turns out to be flexible, and for parameters of an electron, it takes the form of very thin disk with a circular string placed along sharp boundary of the disk. Excitation of this string by a traveling wave creates a circulating singular pole, indicating that the bag-like source of KN solution unifies the dressed and point-like electron in a single bag-string-quark system.

Predicting the Impacts of Climate Change on Central American Agriculture

NASA Astrophysics Data System (ADS)

Winter, J. M.; Ruane, A. C.; Rosenzweig, C.

2011-12-01

Agriculture is a vital component of Central America's economy. Poor crop yields and harvest reliability can produce food insecurity, malnutrition, and conflict. Regional climate models (RCMs) and agricultural models have the potential to greatly enhance the efficiency of Central American agriculture and water resources management under both current and future climates. A series of numerical experiments was conducted using Regional Climate Model Version 3 (RegCM3) and the Weather Research and Forecasting Model (WRF) to evaluate the ability of RCMs to reproduce the current climate of Central America and assess changes in temperature and precipitation under multiple future climate scenarios. Control simulations were thoroughly compared to a variety of observational datasets, including local weather station data, gridded meteorological data, and high-resolution satellite-based precipitation products. Future climate simulations were analyzed for both mean shifts in climate and changes in climate variability, including extreme events (droughts, heat waves, floods). To explore the impacts of changing climate on maize, bean, and rice yields in Central America, RCM output was used to force the Decision Support System for Agrotechnology Transfer Model (DSSAT). These results were synthesized to create climate change impacts predictions for Central American agriculture that explicitly account for evolving distributions of precipitation and temperature extremes.

The impact of the gulf war on the Arabian environment—I. Particulate pollution and reduction of solar irradiance

NASA Astrophysics Data System (ADS)

El-Shobokshy, Mohammad S.; Al-Saedi, Yaseen G.

This paper investigates some of the air pollution problems which have been created as a result of the Gulf war in early 1991. Temporary periods of increased dust storm activity have been observed in Saudi Arabia. This is presumably due to disturbance of the desert surface by the extremely large number of tanks and other war machines before and during the war. The concentrations of inhalable dust particles (<15 μm) increased during the months just after the war by a factor of about 1.5 of their values during the same months of the previous year, 1990. The total horizontal solar energy flux in Riyadh has been significantly reduced during dry days with no clouds. This is attributed to the presence of soot particles, which have been generated at an extremely high rate from the fired oil fields in Kuwait. The direct normal solar insolation were also measured at the photovoltaic solar power plant in Riyadh during these days and significant reductions were observed due to the effective absorption of solar radiation by soot particles. The generated power from the plant has been reduced during days with a polluted atmosphere by about 50-80% of the expected value for such days, if the atmosphere were dry and clear.

Design of a 3D printed lightweight orthotic device based on twisted and coiled polymer muscle: iGrab hand orthosis

NASA Astrophysics Data System (ADS)

Saharan, Lokesh; Sharma, Ashvath; Jung de Andrade, Monica; Baughman, Ray H.; Tadesse, Yonas

2017-04-01

Partial or total upper extremity impairment affects the quality of life of a vast number of people due to stroke, neuromuscular disease, or trauma. Many researchers have presented hand orthosis to address the needs of rehabilitation or assistance on upper extremity function. Most of the devices available commercially and in literature are powered by conventional actuators such as DC motors, servomotors or pneumatic actuators. Some prototypes are developed based on shape memory alloy (SMA) and dielectric elastomers (DE). This study presents a customizable, 3D printed, a lightweight exoskeleton (iGrab) based on recently reported Twisted and Coiled Polymer (TCP) muscles, which are lightweight, provide high power to weight ratio and large stroke. We used silver coated nylon 6, 6 threads to make the TCP muscles, which can be easily actuated electrothermally. We reviewed briefly hand orthosis created with various actuation technologies and present our design of tendon-driven exoskeleton with the muscles confined in the forearm area. A single muscle is used to facilitate the motion of all three joints namely DIP (Distal interphalangeal), PIP (Proximal Interphalangeal) and MCP (Metacarpophalangeal) using passive tendons though circular rings. The grasping capabilities, along with TCP muscle properties utilized in the design such as life cycle, actuation under load and power inputs are discussed.

The other side of the coin: urban heat islands as shields from extreme cold

NASA Astrophysics Data System (ADS)

Yang, J.; Bou-Zeid, E.

2017-12-01

Extensive studies focusing on urban heat islands (UHIs) during hot periods create a perception that UHIs are invariably hazardous to human health and the sustainability of cities. Consequently, cities have invested substantial resources to try to mitigate UHIs. These urban policies can have serious repercussions since the health risks associated with cold weather are in fact higher than for heat episodes, yet wintertime UHIs have hardly been explored. We combine ground observations from 12 U.S. cities and high-resolution simulations to show that UHIs not only warm urban areas in the winter, but also further intensify during cold waves by up to 1.32 ± 0.78 oC (mean ± standard deviation) at night. Urban heat islands serve as shelters against extreme colds and provide invaluable benefits of reducing health risks and heating demand. More importantly, our simulations indicate that standard UHI mitigation measures such as green or cool roofs reduce these cold time amenities to different extents. Cities, particularly in cool and cold temperate climates, should hence revisit policies and efforts that are only desgined for hot periods. A paradigm shift is urgently needed to give an equal weight to the wintertime benefits of UHIs in the sustainability and resilience blueprints of cities.

Magnetic Resonance Imaging of Phosphocreatine and Determination of BOLD Kinetics in Lower Extremity Muscles using a Dual-Frequency Coil Array

NASA Astrophysics Data System (ADS)

Brown, Ryan; Khegai, Oleksandr; Parasoglou, Prodromos

2016-07-01

Magnetic resonance imaging (MRI) provides the unique ability to study metabolic and microvasculature functions in skeletal muscle using phosphorus and proton measurements. However, the low sensitivity of these techniques can make it difficult to capture dynamic muscle activity due to the temporal resolution required for kinetic measurements during and after exercise tasks. Here, we report the design of a dual-nuclei coil array that enables proton and phosphorus MRI of the human lower extremities with high spatial and temporal resolution. We developed an array with whole-volume coverage of the calf and a phosphorus signal-to-noise ratio of more than double that of a birdcage coil in the gastrocnemius muscles. This enabled the local assessment of phosphocreatine recovery kinetics following a plantar flexion exercise using an efficient sampling scheme with a 6 s temporal resolution. The integrated proton array demonstrated image quality approximately equal to that of a clinical state-of-the-art knee coil, which enabled fat quantification and dynamic blood oxygen level-dependent measurements that reflect microvasculature function. The developed array and time-efficient pulse sequences were combined to create a localized assessment of calf metabolism using phosphorus measurements and vasculature function using proton measurements, which could provide new insights into muscle function.

Computing the proton aurora at early Mars

NASA Astrophysics Data System (ADS)

Lovato, K.; Gronoff, G.; Curry, S.; Simon Wedlund, C.; Moore, W. B.

2017-12-01

In the early Solar System, ( 4 Gyr ago) our Sun was 70% less luminous than what is seen today but much more active. Indeed, for young stars, solar flares occurs more frequently and therefore so do coronal mass ejections and solar energetic particle events. With an increase in solar events, the flux of protons becomes extremely high, and affects planetary atmosphere in a more extreme way as today. Proton precipitation on planets has an impact on the energy balance of their upper atmospheres, can affect the photochemistry and create auroral emissions. Understanding the protons precipitation at the early Mars can help in understanding occurring chemical process as well as atmospheric evolution and escape. We concentrated our effort on the proton up to a MeV since they have the most important influence on the upper atmosphere. Using scaling laws, we estimated the proton flux for the Early Mars up to a MeV. A kinetic 1D code, validated for the current Mars, was used to compute the effects of the low energy protons precipitation on the Early Mars. This model solves the coupled H+/H multi-stream dissipative transport equation as well as the transport of the secondary electron. For the Early Mars, it allowed to compute the magnitude of the proton Aurora, as well as the corresponding upwards H flux.

Generation of Boundary Manikin Anthropometry

NASA Technical Reports Server (NTRS)

Young, Karen S.; Margerum, Sarah; Barr, Abbe; Ferrer, Mike A.; Rajulu, Sudhakar

2008-01-01

The purpose of this study was to develop 3D digital boundary manikins that are representative of the anthropometry of a unique population. These digital manikins can be used by designers to verify and validate that the components of the spacesuit design satisfy the requirements specified in the Human Systems Integration Requirements (HSIR) document. Currently, the HSIR requires the suit to accommodate the 1st percentile American female to the 99th percentile American male. The manikin anthropometry was derived using two methods: Principal Component Analysis (PCA) and Whole Body Posture Based Analysis (WBPBA). PCA is a statistical method for reducing a multidimensional data set by using eigenvectors and eigenvalues. The goal is to create a reduced data set that encapsulates the majority of the variation in the population. WBPBA is a multivariate analytical approach that was developed by the Anthropometry and Biomechanics Facility (ABF) to identify the extremes of the population for a given body posture. WBPBA is a simulation-based method that finds extremes in a population based on anthropometry and posture whereas PCA is based solely on anthropometry. Both methods yield a list of subjects and their anthropometry from the target population; PCA resulted in 20 female and 22 male subjects anthropometry and WBPBA resulted in 7 subjects' anthropometry representing the extreme subjects in the target population. The subjects anthropometry is then used to 'morph' a baseline digital scan of a person with the same body type to create a 3D digital model that can be used as a tool for designers, the details of which will be discussed in subsequent papers.

Spatiotemporal Detection of Unusual Human Population Behavior Using Mobile Phone Data

PubMed Central

Dobra, Adrian; Williams, Nathalie E.; Eagle, Nathan

2015-01-01

With the aim to contribute to humanitarian response to disasters and violent events, scientists have proposed the development of analytical tools that could identify emergency events in real-time, using mobile phone data. The assumption is that dramatic and discrete changes in behavior, measured with mobile phone data, will indicate extreme events. In this study, we propose an efficient system for spatiotemporal detection of behavioral anomalies from mobile phone data and compare sites with behavioral anomalies to an extensive database of emergency and non-emergency events in Rwanda. Our methodology successfully captures anomalous behavioral patterns associated with a broad range of events, from religious and official holidays to earthquakes, floods, violence against civilians and protests. Our results suggest that human behavioral responses to extreme events are complex and multi-dimensional, including extreme increases and decreases in both calling and movement behaviors. We also find significant temporal and spatial variance in responses to extreme events. Our behavioral anomaly detection system and extensive discussion of results are a significant contribution to the long-term project of creating an effective real-time event detection system with mobile phone data and we discuss the implications of our findings for future research to this end. PMID:25806954

Application of principal component analysis (PCA) and improved joint probability distributions to the inverse first-order reliability method (I-FORM) for predicting extreme sea states

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eckert-Gallup, Aubrey C.; Sallaberry, Cédric J.; Dallman, Ann R.

Environmental contours describing extreme sea states are generated as the input for numerical or physical model simulations as a part of the standard current practice for designing marine structures to survive extreme sea states. These environmental contours are characterized by combinations of significant wave height (H s) and either energy period (T e) or peak period (T p) values calculated for a given recurrence interval using a set of data based on hindcast simulations or buoy observations over a sufficient period of record. The use of the inverse first-order reliability method (I-FORM) is a standard design practice for generating environmentalmore » contours. This paper develops enhanced methodologies for data analysis prior to the application of the I-FORM, including the use of principal component analysis (PCA) to create an uncorrelated representation of the variables under consideration as well as new distribution and parameter fitting techniques. As a result, these modifications better represent the measured data and, therefore, should contribute to the development of more realistic representations of environmental contours of extreme sea states for determining design loads for marine structures.« less

Application of principal component analysis (PCA) and improved joint probability distributions to the inverse first-order reliability method (I-FORM) for predicting extreme sea states

DOE PAGES

Eckert-Gallup, Aubrey C.; Sallaberry, Cédric J.; Dallman, Ann R.; ...

2016-01-06

Environmental contours describing extreme sea states are generated as the input for numerical or physical model simulations as a part of the standard current practice for designing marine structures to survive extreme sea states. These environmental contours are characterized by combinations of significant wave height (H s) and either energy period (T e) or peak period (T p) values calculated for a given recurrence interval using a set of data based on hindcast simulations or buoy observations over a sufficient period of record. The use of the inverse first-order reliability method (I-FORM) is a standard design practice for generating environmentalmore » contours. This paper develops enhanced methodologies for data analysis prior to the application of the I-FORM, including the use of principal component analysis (PCA) to create an uncorrelated representation of the variables under consideration as well as new distribution and parameter fitting techniques. As a result, these modifications better represent the measured data and, therefore, should contribute to the development of more realistic representations of environmental contours of extreme sea states for determining design loads for marine structures.« less

Extreme precipitation in the Polish Carpathians in the 20th century in the context of last 500 years

NASA Astrophysics Data System (ADS)

Limanowka, Danuta; Cebulak, Elzbieta; Pyrc, Robert

2010-05-01

Extreme weather phenomena together with their exceptional course and intensity have always been dangerous for people. In the historical documents such phenomena were marked as basic disasters. First notes about weather phenomena were made in Polish lands in the 10th century. Most information concerns floods caused by intensive rains. Using the data base created within the Millennium project, extreme precipitation cases exceeding 100 mm were analysed. In each case, the intensive precipitation was followed by a summer flood in the Polish Carpathians in the Upper Vistula River basin. Data from the period of instrumental measurements in the 20th century were studied in detail by the analysis of the frequency of occurrence and the spatial and temporal distribution. The results were referred to last 500 years. The information obtained gives approximate image of extreme precipitation in the historical times in Polish lands. All available multi-proxy data were used. Newspapers' notes concerning described phenomena from 1848-1850 published in Kraków were used to complete and verify the quality of data from the early instrumental period and also to complete the data from the period of the Second World War.

Extreme High-Temperature Events Over East Asia in 1.5°C and 2°C Warmer Futures: Analysis of NCAR CESM Low-Warming Experiments

NASA Astrophysics Data System (ADS)

Li, Donghuan; Zhou, Tianjun; Zou, Liwei; Zhang, Wenxia; Zhang, Lixia

2018-02-01

Extreme high-temperature events have large socioeconomic and human health impacts. East Asia (EA) is a populous region, and it is crucial to assess the changes in extreme high-temperature events in this region under different climate change scenarios. The Community Earth System Model low-warming experiment data were applied to investigate the changes in the mean and extreme high temperatures in EA under 1.5°C and 2°C warming conditions above preindustrial levels. The results show that the magnitude of warming in EA is approximately 0.2°C higher than the global mean. Most populous subregions, including eastern China, the Korean Peninsula, and Japan, will see more intense, more frequent, and longer-lasting extreme temperature events under 1.5°C and 2°C warming. The 0.5°C lower warming will help avoid 35%-46% of the increases in extreme high-temperature events in terms of intensity, frequency, and duration in EA with maximal avoidance values (37%-49%) occurring in Mongolia. Thus, it is beneficial for EA to limit the warming target to 1.5°C rather than 2°C.

Promising Results from Three NASA SBIR Solar Array Technology Development Programs

NASA Technical Reports Server (NTRS)

Eskenazi, Mike; White, Steve; Spence, Brian; Douglas, Mark; Glick, Mike; Pavlick, Ariel; Murphy, David; O'Neill, Mark; McDanal, A. J.; Piszczor, Michael

2005-01-01

Results from three NASA SBIR solar array technology programs are presented. The programs discussed are: 1) Thin Film Photovoltaic UltraFlex Solar Array; 2) Low Cost/Mass Electrostatically Clean Solar Array (ESCA); and 3) Stretched Lens Array SquareRigger (SLASR). The purpose of the Thin Film UltraFlex (TFUF) Program is to mature and validate the use of advanced flexible thin film photovoltaics blankets as the electrical subsystem element within an UltraFlex solar array structural system. In this program operational prototype flexible array segments, using United Solar amorphous silicon cells, are being manufactured and tested for the flight qualified UltraFlex structure. In addition, large size (e.g. 10 kW GEO) TFUF wing systems are being designed and analyzed. Thermal cycle and electrical test and analysis results from the TFUF program are presented. The purpose of the second program entitled, Low Cost/Mass Electrostatically Clean Solar Array (ESCA) System, is to develop an Electrostatically Clean Solar Array meeting NASA s design requirements and ready this technology for commercialization and use on the NASA MMS and GED missions. The ESCA designs developed use flight proven materials and processes to create a ESCA system that yields low cost, low mass, high reliability, high power density, and is adaptable to any cell type and coverglass thickness. All program objectives, which included developing specifications, creating ESCA concepts, concept analysis and trade studies, producing detailed designs of the most promising ESCA treatments, manufacturing ESCA demonstration panels, and LEO (2,000 cycles) and GEO (1,350 cycles) thermal cycling testing of the down-selected designs were successfully achieved. The purpose of the third program entitled, "High Power Platform for the Stretched Lens Array," is to develop an extremely lightweight, high efficiency, high power, high voltage, and low stowed volume solar array suitable for very high power (multi-kW to MW) applications. These objectives are achieved by combining two cutting edge technologies, the SquareRigger solar array structure and the Stretched Lens Array (SLA). The SLA SquareRigger solar array is termed SLASR. All program objectives, which included developing specifications, creating preliminary designs for a near-term SLASR, detailed structural, mass, power, and sizing analyses, fabrication and power testing of a functional flight-like SLASR solar blanket, were successfully achieved.

Education and Public Outreach and Engagement at NASA's Analog Missions in 2012

NASA Technical Reports Server (NTRS)

Watkins, Wendy L.; Janoiko, Barbara A.; Mahoney, Erin; Hermann, Nicole B.

2013-01-01

Analog missions are integrated, multi-disciplinary activities that test key features of future human space exploration missions in an integrated fashion to gain a deeper understanding of system-level interactions and operations early in conceptual development. These tests often are conducted in remote and extreme environments that are representative in one or more ways to that of future spaceflight destinations. They may also be conducted at NASA facilities, using advanced modeling and human-in-the-loop scenarios. As NASA develops a capability driven framework to transport crew to a variety of space environments, it will use analog missions to gather requirements and develop the technologies necessary to ensure successful exploration beyond low Earth orbit. NASA s Advanced Exploration Systems (AES) Division conducts these high-fidelity integrated tests, including the coordination and execution of a robust education and public outreach (EPO) and engagement program for each mission. Conducting these mission scenarios in unique environments not only provides an opportunity to test the EPO concepts for the particular future-mission scenario, such as the best methods for conducting events with a communication time delay, but it also provides an avenue to deliver NASA s human space exploration key messages. These analogs are extremely exciting to students and the public, and they are performed in such a way that the public can feel like part of the mission. They also provide an opportunity for crew members to obtain training in education and public outreach activities similar to what they would perform in space. The analog EPO team is responsible for the coordination and execution of the events, the overall social media component for each mission, and public affairs events such as media visits and interviews. They also create new and exciting ways to engage the public, manage and create website content, coordinate video footage for missions, and coordinate and integrate each activity into the mission timeline. In 2012, the AES Analog Missions Project performed three distinct missions - NASA Extreme Environment Mission Operations (NEEMO), which simulated a mission to an asteroid using an undersea laboratory; In-Situ Resource Utilization (ISRU) Field Test, which simulated a robotic mission to the moon searching and drilling for water; and Research and Technology Studies (RATS) integrated tests, which also simulated a mission to an asteroid. This paper will discuss the education and public engagement that occurred during these missions.

Trends in body mass index and prevalence of extreme high obesity among Pennsylvania children and adolescents, 2007-2011: promising but cautionary.

PubMed

Lohrmann, David; YoussefAgha, Ahmed; Jayawardene, Wasantha

2014-04-01

We determined current trends and patterns in overweight, obesity, and extreme high obesity among Pennsylvania pre-kindergarten (pre-K) to 12th grade students and simulated future trends. We analyzed body mass index (BMI) of pre-K to 12th grade students from 43 of 67 Pennsylvania counties in 2007 to 2011 to determine trends and to discern transition patterns among BMI status categories for 2009 to 2011. Vinsem simulation, confirmed by Markov chain modeling, generated future prevalence trends. Combined rates of overweight, obesity, and extreme high obesity decreased among secondary school students across the 5 years, and among elementary students, first increased and then markedly decreased. BMI status remained constant for approximately 80% of normal and extreme high obese students, but both decreased and increased among students who initially were overweight and obese; the increase in BMI remained significant. Overall trends in child and adolescent BMI status seemed positive. BMI transition patterns indicated that although overweight and obesity prevalence leveled off, extreme high obesity, especially among elementary students, is projected to increase substantially over time. If current transition patterns continue, the prevalence of overweight, obesity, and extreme high obesity among Pennsylvania students in 2031 is projected to be 16.0%, 6.6%, and 23.2%, respectively.

Optimizing defect inspection strategy through the use of design-aware database control layers

NASA Astrophysics Data System (ADS)

Stoler, Dvori; Ruch, Wayne; Ma, Weimin; Chakravarty, Swapnajit; Liu, Steven; Morgan, Ray; Valadez, John; Moore, Bill; Burns, John

2007-10-01

Resolution limitations in the mask making process can cause differences between the features that appear in a database and those printed to a reticle. These differences may result from intentional or unintentional features in the database exceeding the resolution limit of the mask making process such as small gaps or lines in the data, line end shortening on small sub-resolution assist features etc creating challenges to both mask writing and mask inspection. Areas with high variance from design to mask, often referred to as high MEEF areas (mask error enhancement factor), become highly problematic and can directly impact mask and device yield, mask manufacturing cycle time and ultimately mask costs. Specific to mask inspection it may be desirable to inspect certain non-critical or non-relevant features at reduced sensitivity so as not to detect real, but less significant process defects. In contrast there may also be times where increased sensitivity is required for critical mask features or areas. Until recently, this process was extremely manual, creating added time and cost to the mask inspection cycle. Shifting to more intelligent and automated inspection flows is the key focus of this paper. A novel approach to importing design data directly into the mask inspection to include both MDP generated MRC errors files and LRC generated MEEF files. The results of recently developed inspection and review capability based upon controlling defect inspection using design aware data base control layers on a pixel basis are discussed. Typical mask shop applications and implementations will be shown.

A compliant mechanism for inspecting extremely confined spaces

NASA Astrophysics Data System (ADS)

Mascareñas, David; Moreu, Fernando; Cantu, Precious; Shields, Daniel; Wadden, Jack; El Hadedy, Mohamed; Farrar, Charles

2017-11-01

We present a novel, compliant mechanism that provides the capability to navigate extremely confined spaces for the purpose of infrastructure inspection. Extremely confined spaces are commonly encountered during infrastructure inspection. Examples of such spaces can include pipes, conduits, and ventilation ducts. Often these infrastructure features go uninspected simply because there is no viable way to access their interior. In addition, it is not uncommon for extremely confined spaces to possess a maze-like architecture that must be selectively navigated in order to properly perform an inspection. Efforts by the imaging sensor community have resulted in the development of imaging sensors on the millimeter length scale. Due to their compact size, they are able to inspect many extremely confined spaces of interest, however, the means to deliver these sensors to the proper location to obtain the desired images are lacking. To address this problem, we draw inspiration from the field of endoscopic surgery. Specifically we consider the work that has already been done to create long flexible needles that are capable of being steered through the human body. These devices are typically referred to as ‘steerable needles.’ Steerable needle technology is not directly applicable to the problem of navigating maze-like arrangements of extremely confined spaces, but it does provide guidance on how this problem should be approached. Specifically, the super-elastic nitinol tubing material that allows steerable needles to operate is also appropriate for the problem of navigating maze-like arrangements of extremely confined spaces. Furthermore, the portion of the mechanism that enters the extremely confined space is completely mechanical in nature. The mechanical nature of the device is an advantage when the extremely confined space features environmental hazards such as radiation that could degrade an electromechanically operated mechanism. Here, we present a compliant mechanism developed to navigate maze-like arrangements of extremely confined spaces. The mechanism is shown to be able to selectively navigate past three 90° bends. The ability to selectively navigate extremely confined spaces opens up new possibilities to use emerging miniature imaging technology for infrastructure inspection.

The effects of floor incline on lower extremity biomechanics during unilateral landing from a jump in dancers.

PubMed

Pappas, Evangelos; Orishimo, Karl F; Kremenic, Ian; Liederbach, Marijeanne; Hagins, Marshall

2012-05-01

Retrospective studies have suggested that dancers performing on inclined ("raked") stages have increased injury risk. One study suggests that biomechanical differences exist between flat and inclined surfaces during bilateral landings; however, no studies have examined whether such differences exist during unilateral landings. In addition, little is known regarding potential gender differences in landing mechanics of dancers. Professional dancers (N = 41; 14 male, 27 female) performed unilateral drop jumps from a 30 cm platform onto flat and inclined surfaces while extremity joint angles and moments were identified and analyzed. There were significant joint angle and moment effects due to the inclined flooring. Women had significantly decreased peak ankle dorsiflexion and hip adduction moment compared with men. Findings of the current study suggest that unilateral landings on inclined stages create measurable changes in lower extremity biomechanical variables. These findings provide a preliminary biomechanical rationale for differences in injury rates found in observational studies of raked stages.

Workers' compensation claims for musculoskeletal disorders and injuries of the upper extremity and knee among union carpenters in Washington State, 1989-2008.

PubMed

Lipscomb, Hester J; Schoenfisch, Ashley L; Cameron, Wilfrid; Kucera, Kristen L; Adams, Darrin; Silverstein, Barbara A

2015-04-01

Numerous aspects of construction place workers at risk of musculoskeletal disorders and injuries (MSDIs). Work organization and the nature of MSDIs create surveillance challenges. By linking union records with workers' compensation claims, we examined 20-year patterns of MSDIs involving the upper extremity (UE) and the knee among a large carpenter cohort. MSDIs were common and accounted for a disproportionate share of paid lost work time (PLT) claims; UE MSDIs were three times more common than those of the knee. Rates declined markedly over time and were most pronounced for MSDIs of the knee with PLT. Patterns of risk varied by extremity, as well as by age, gender, union tenure, and predominant work. Carpenters in drywall installation accounted for the greatest public health burden. A combination of factors likely account for the patterns observed over time and across worker characteristics. Drywall installers are an intervention priority. © 2015 Wiley Periodicals, Inc.

In situ cephalic vein bypasses from axillary to the brachial artery after catheterization injuries.

PubMed

Hudorovic, Narcis; Lovricevic, Ivo; Ahel, Zaky

2010-07-01

The need to bypass to the brachial artery is rare. Over a five-year period, 16 patients had suffered iatrogenic post-catheterization injuries of the upper extremity. We have performed 16 bypasses, in 16 patients, mean age was 65 years (range 47-75), to the brachial artery originating from an artery proximal to the shoulder joint. In all cases, the axillary artery was the donor artery. All bypasses were created by using the cephalic vein with the in situ technique and distal anastomoses were made to a distance-free section of brachial artery. No operative mortality, neurological complications or major upper-extremity amputation was associated with the procedure. Life-long-conduit analysis showed 75% patency in the five-year period. After iatrogenic post-catheterization trauma of arterial system of upper extremity, bypasses from axillary to brachial artery with the cephalic vein with the in situ technique is a safe operation with satisfactory long-term patency.

shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics.

PubMed

Khomtchouk, Bohdan B; Hennessy, James R; Wahlestedt, Claes

2017-01-01

Transcriptomics, metabolomics, metagenomics, and other various next-generation sequencing (-omics) fields are known for their production of large datasets, especially across single-cell sequencing studies. Visualizing such big data has posed technical challenges in biology, both in terms of available computational resources as well as programming acumen. Since heatmaps are used to depict high-dimensional numerical data as a colored grid of cells, efficiency and speed have often proven to be critical considerations in the process of successfully converting data into graphics. For example, rendering interactive heatmaps from large input datasets (e.g., 100k+ rows) has been computationally infeasible on both desktop computers and web browsers. In addition to memory requirements, programming skills and knowledge have frequently been barriers-to-entry for creating highly customizable heatmaps. We propose shinyheatmap: an advanced user-friendly heatmap software suite capable of efficiently creating highly customizable static and interactive biological heatmaps in a web browser. shinyheatmap is a low memory footprint program, making it particularly well-suited for the interactive visualization of extremely large datasets that cannot typically be computed in-memory due to size restrictions. Also, shinyheatmap features a built-in high performance web plug-in, fastheatmap, for rapidly plotting interactive heatmaps of datasets as large as 105-107 rows within seconds, effectively shattering previous performance benchmarks of heatmap rendering speed. shinyheatmap is hosted online as a freely available web server with an intuitive graphical user interface: http://shinyheatmap.com. The methods are implemented in R, and are available as part of the shinyheatmap project at: https://github.com/Bohdan-Khomtchouk/shinyheatmap. Users can access fastheatmap directly from within the shinyheatmap web interface, and all source code has been made publicly available on Github: https://github.com/Bohdan-Khomtchouk/fastheatmap.

Combining structure-from-motion derived point clouds from satellites and unmanned aircraft systems images with ground-truth data to create high-resolution digital elevation models

NASA Astrophysics Data System (ADS)

Palaseanu, M.; Thatcher, C.; Danielson, J.; Gesch, D. B.; Poppenga, S.; Kottermair, M.; Jalandoni, A.; Carlson, E.

2016-12-01

Coastal topographic and bathymetric (topobathymetric) data with high spatial resolution (1-meter or better) and high vertical accuracy are needed to assess the vulnerability of Pacific Islands to climate change impacts, including sea level rise. According to the Intergovernmental Panel on Climate Change reports, low-lying atolls in the Pacific Ocean are extremely vulnerable to king tide events, storm surge, tsunamis, and sea-level rise. The lack of coastal topobathymetric data has been identified as a critical data gap for climate vulnerability and adaptation efforts in the Republic of the Marshall Islands (RMI). For Majuro Atoll, home to the largest city of RMI, the only elevation dataset currently available is the Shuttle Radar Topography Mission data which has a 30-meter spatial resolution and 16-meter vertical accuracy (expressed as linear error at 90%). To generate high-resolution digital elevation models (DEMs) in the RMI, elevation information and photographic imagery have been collected from field surveys using GNSS/total station and unmanned aerial vehicles for Structure-from-Motion (SfM) point cloud generation. Digital Globe WorldView II imagery was processed to create SfM point clouds to fill in gaps in the point cloud derived from the higher resolution UAS photos. The combined point cloud data is filtered and classified to bare-earth and georeferenced using the GNSS data acquired on roads and along survey transects perpendicular to the coast. A total station was used to collect elevation data under tree canopies where heavy vegetation cover blocked the view of GNSS satellites. A subset of the GPS / total station data was set aside for error assessment of the resulting DEM.

Lower extremity muscle activation during baseball pitching.

PubMed

Campbell, Brian M; Stodden, David F; Nixon, Megan K

2010-04-01

The purpose of this study was to investigate muscle activation levels of select lower extremity muscles during the pitching motion. Bilateral surface electromyography data on 5 lower extremity muscles (biceps femoris, rectus femoris, gluteus maximus, vastus medialis, and gastrocnemius) were collected on 11 highly skilled baseball pitchers and compared with individual maximal voluntary isometric contraction (MVIC) data. The pitching motion was divided into 4 distinct phases: phase 1, initiation of pitching motion to maximum stride leg knee height; phase 2, maximum stride leg knee height to stride foot contact (SFC); phase 3, SFC to ball release; and phase 4, ball release to 0.5 seconds after ball release (follow-through). Results indicated that trail leg musculature elicited moderate to high activity levels during phases 2 and 3 (38-172% of MVIC). Muscle activity levels of the stride leg were moderate to high during phases 2-4 (23-170% of MVIC). These data indicate a high demand for lower extremity strength and endurance. Specifically, coaches should incorporate unilateral and bilateral lower extremity exercises for strength improvement or maintenance and to facilitate dynamic stabilization of the lower extremities during the pitching motion.

Managing outbreaks of norovirus in an NHS hospital.

PubMed

Aziz, Ann-Marie

Noroviruses are highly infectious and easily transmitted by contact with contaminated surfaces and objects, as airborne particles and by contact between individuals. While illness caused by norovirus is usually self-limiting, it can be serious in very young and elderly people, or in those who are debilitated or have a serious illness; they may require hospital treatment. Norovirus outbreaks in hospitals create significant disruption to patient care. They also have huge cost implications for NHS trusts through staff absence and ward closures, which are extremely disruptive and increase pressures on bed demand. The three most important actions during an outbreak of norovirus are effective hand hygiene, isolation of affected patients and enhanced cleaning of the environment. This article outlines how to identify norovirus infection and outbreaks, and describes how an acute trust managed outbreaks of norovirus and the procedures it adopted.

Design and Error Analysis of a Vehicular AR System with Auto-Harmonization.

PubMed

Foxlin, Eric; Calloway, Thomas; Zhang, Hongsheng

2015-12-01

This paper describes the design, development and testing of an AR system that was developed for aerospace and ground vehicles to meet stringent accuracy and robustness requirements. The system uses an optical see-through HMD, and thus requires extremely low latency, high tracking accuracy and precision alignment and calibration of all subsystems in order to avoid mis-registration and "swim". The paper focuses on the optical/inertial hybrid tracking system and describes novel solutions to the challenges with the optics, algorithms, synchronization, and alignment with the vehicle and HMD systems. Tracker accuracy is presented with simulation results to predict the registration accuracy. A car test is used to create a through-the-eyepiece video demonstrating well-registered augmentations of the road and nearby structures while driving. Finally, a detailed covariance analysis of AR registration error is derived.

Crew Launch Vehicle Mobile Launcher Solid Rocket Motor Plume Induced Environment

NASA Technical Reports Server (NTRS)

Vu, Bruce T.; Sulyma, Peter

2008-01-01

The plume-induced environment created by the Ares 1 first stage, five-segment reusable solid rocket motor (RSRMV) will impose high heating rates and impact pressures on Launch Complex 39. The extremes of these environments pose a potential threat to weaken or even cause structural components to fail if insufficiently designed. Therefore the ability to accurately predict these environments is critical to assist in specifying structural design requirements to insure overall structural integrity and flight safety. This paper presents the predicted thermal and pressure environments induced by the launch of the Crew Launch Vehicle (CLV) from Launch Complex (LC) 39. Once the environments are predicted, a follow-on thermal analysis is required to determine the surface temperature response and the degradation rate of the materials. An example of structures responding to the plume-induced environment will be provided.

Localized surface plasmons in vibrating graphene nanodisks

NASA Astrophysics Data System (ADS)

Wang, Weihua; Li, Bo-Hong; Stassen, Erik; Mortensen, N. Asger; Christensen, Johan

2016-02-01

Localized surface plasmons are confined collective oscillations of electrons in metallic nanoparticles. When driven by light, the optical response is dictated by geometrical parameters and the dielectric environment and plasmons are therefore extremely important for sensing applications. Plasmons in graphene disks have the additional benefit of being highly tunable via electrical stimulation. Mechanical vibrations create structural deformations in ways where the excitation of localized surface plasmons can be strongly modulated. We show that the spectral shift in such a scenario is determined by a complex interplay between the symmetry and shape of the modal vibrations and the plasmonic mode pattern. Tuning confined modes of light in graphene via acoustic excitations, paves new avenues in shaping the sensitivity of plasmonic detectors, and in the enhancement of the interaction with optical emitters, such as molecules, for future nanophotonic devices.

Racial residential segregation: a fundamental cause of racial disparities in health.

PubMed

Williams, D R; Collins, C

2001-01-01

Racial residential segregation is a fundamental cause of racial disparities in health. The physical separation of the races by enforced residence in certain areas is an institutional mechanism of racism that was designed to protect whites from social interaction with blacks. Despite the absence of supportive legal statutes, the degree of residential segregation remains extremely high for most African Americans in the United States. The authors review evidence that suggests that segregation is a primary cause of racial differences in socioeconomic status (SES) by determining access to education and employment opportunities. SES in turn remains a fundamental cause of racial differences in health. Segregation also creates conditions inimical to health in the social and physical environment. The authors conclude that effective efforts to eliminate racial disparities in health must seriously confront segregation and its pervasive consequences.

EXTREME AO OBSERVATIONS OF TWO TRIPLE ASTEROID SYSTEMS WITH SPHERE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, B.; Wahhaj, Z.; Dumas, C.

We present the discovery of a new satellite of asteroid (130) Elektra—S/2014 (130) 1—in differential imaging and in integral field spectroscopy data over multiple epochs obtained with Spectro-Polarimetric High-contrast Exoplanet Research/Very Large Telescope. This new (second) moonlet of Elektra is about 2 km across, on an eccentric orbit, and about 500 km away from the primary. For a comparative study, we also observed another triple asteroid system, (93) Minerva. For both systems, component-resolved reflectance spectra of the satellites and primary were obtained simultaneously. No significant spectral difference was observed between the satellites and the primary for either triple system. Wemore » find that the moonlets in both systems are more likely to have been created by sub-disruptive impacts as opposed to having been captured.« less

SVGA and XGA active matrix microdisplays for head-mounted applications

NASA Astrophysics Data System (ADS)

Alvelda, Phillip; Bolotski, Michael; Brown, Imani L.

2000-03-01

The MicroDisplay Corporation's liquid crystal on silicon (LCOS) display devices are based on the union of several technologies with the extreme integration capability of conventionally fabricated CMOS substrates. The fast liquid crystal operation modes and new scalable high-performance pixel addressing architectures presented in this paper enable substantially improved color, contrast, and brightness while still satisfying the optical, packaging, and power requirements of portable applications. The entire suite of MicroDisplay's technologies was devised to create a line of mixed-signal application-specific integrated circuits (ASICs) in single-chip display systems. Mixed-signal circuits can integrate computing, memory, and communication circuitry on the same substrate as the display drivers and pixel array for a multifunctional complete system-on-a-chip. System-on-a-chip benefits also include reduced head supported weight requirements through the elimination of off-chip drive electronics.

Generalist genes and high cognitive abilities.

PubMed

Haworth, Claire M A; Dale, Philip S; Plomin, Robert

2009-07-01

The concept of generalist genes operating across diverse domains of cognitive abilities is now widely accepted. Much less is known about the etiology of the high extreme of performance. Is there more specialization at the high extreme? Using a representative sample of 4,000 12-year-old twin pairs from the UK Twins Early Development Study, we investigated the genetic and environmental overlap between web-based tests of general cognitive ability, reading, mathematics and language performance for the top 15% of the distribution using DF extremes analysis. Generalist genes are just as evident at the high extremes of performance as they are for the entire distribution of abilities and for cognitive disabilities. However, a smaller proportion of the phenotypic intercorrelations appears to be explained by genetic influences for high abilities.

Generalist genes and high cognitive abilities

PubMed Central

Haworth, Claire M.A.; Dale, Philip S.; Plomin, Robert

2014-01-01

The concept of generalist genes operating across diverse domains of cognitive abilities is now widely accepted. Much less is known about the etiology of the high extreme of performance. Is there more specialization at the high extreme? Using a representative sample of 4000 12-year-old twin pairs from the UK Twins Early Development Study, we investigated the genetic and environmental overlap between web-based tests of general cognitive ability, reading, mathematics and language performance for the top 15% of the distribution using DF extremes analysis. Generalist genes are just as evident at the high extremes of performance as they are for the entire distribution of abilities and for cognitive disabilities. However, a smaller proportion of the phenotypic intercorrelations appears to be explained by genetic influences for high abilities. PMID:19377870

R2R - software to speed the depiction of aesthetic consensus RNA secondary structures

PubMed Central

2011-01-01

Background With continuing identification of novel structured noncoding RNAs, there is an increasing need to create schematic diagrams showing the consensus features of these molecules. RNA structural diagrams are typically made either with general-purpose drawing programs like Adobe Illustrator, or with automated or interactive programs specific to RNA. Unfortunately, the use of applications like Illustrator is extremely time consuming, while existing RNA-specific programs produce figures that are useful, but usually not of the same aesthetic quality as those produced at great cost in Illustrator. Additionally, most existing RNA-specific applications are designed for drawing single RNA molecules, not consensus diagrams. Results We created R2R, a computer program that facilitates the generation of aesthetic and readable drawings of RNA consensus diagrams in a fraction of the time required with general-purpose drawing programs. Since the inference of a consensus RNA structure typically requires a multiple-sequence alignment, the R2R user annotates the alignment with commands directing the layout and annotation of the RNA. R2R creates SVG or PDF output that can be imported into Adobe Illustrator, Inkscape or CorelDRAW. R2R can be used to create consensus sequence and secondary structure models for novel RNA structures or to revise models when new representatives for known RNA classes become available. Although R2R does not currently have a graphical user interface, it has proven useful in our efforts to create 100 schematic models of distinct noncoding RNA classes. Conclusions R2R makes it possible to obtain high-quality drawings of the consensus sequence and structural models of many diverse RNA structures with a more practical amount of effort. R2R software is available at http://breaker.research.yale.edu/R2R and as an Additional file. PMID:21205310

Intra-seasonal Characteristics of Wintertime Extreme Cold Events over South Korea

NASA Astrophysics Data System (ADS)

Park, Taewon; Jeong, Jeehoon; Choi, Jahyun

2017-04-01

The present study reveals the changes in the characteristics of extreme cold events over South Korea for boreal winter (November to March) in terms of the intra-seasonal variability of frequency, duration, and atmospheric circulation pattern. Influences of large-scale variabilities such as the Siberian High activity, the Arctic Oscillation (AO), and the Madden-Julian Oscillation (MJO) on extreme cold events are also investigated. In the early and the late of the winter during November and March, the upper-tropospheric wave-train for a life-cycle of the extreme cold events tends to pass quickly over East Asia. In addition, compared with the other months, the intensity of the Siberian High is weaker and the occurrences of strong negative AO are less frequent. It lead to events with weak amplitude and short duration. On the other hand, the amplified Siberian High and the strong negative AO occur more frequently in the mid of the winter from December to February. The extreme cold events are mainly characterized by a well-organized anticyclonic blocking around the Ural Mountain and the Subarctic. These large-scale circulation makes the extreme cold events for the midwinter last long with strong amplitude. The MJO phases 2-3 which provide a suitable condition for the amplification of extreme cold events occur frequently for November to January when the frequencies are more than twice those for February and March. While the extreme cold events during March have the least frequency, the weakest amplitude, and the shortest duration due to weak impacts of the abovementioned factors, the strong activities of the factors for January force the extreme cold events to be the most frequent, the strongest, and the longest among the boreal winter. Keywords extreme cold event, wave-train, blocking, Siberian High, AO, MJO

Studies of the QCD Phase Diagram with Heavy-Ion Collisions at J-PARC

NASA Astrophysics Data System (ADS)

Sako, Hiroyuki

To clarify phase structures in the QCD phase diagram is an ultimate goal of heavy-ion collision experiments. Studies of internal structures of neutron stars are also one of the most important topics of nuclear physics since the discovery of neutron stars with two-solar mass. For these physics goals, J-PARC heavy-ion project (J-PARC-HI) has been proposed, where extremely dense matter with 5-10 times the normal nuclear density will be created. Heavy-ion beams up to Uranium will be accelerated to 1-19 AGeV/c, with the designed world's highest beam rate of 1011 Hz. The acceleration of such high-rate beams can be realized by a new heavy-ion linac and a new booster ring, in addition to the existing 3-GeV and 50-GeV proton synchrotrons. To study the above physics goals, following physics observables will be measured in extremely high statistics expected in J-PARC-HI. To search for the critical point, high-order event-by-event fluctuations of conserved charges such as a net-baryon number, an electric charge number, and a strangeness number will be measured. To study the chiral symmetry restoration, dilepton spectra from light vector meson decays will be measured. Also, collective flows, particle correlations will be measured to study the equation of state and hyperon-hyperon and hyperon-nucleon interactions related to neutron stars. Strange quark matter (strangelet) and multi-strangeness hypernuclei will be searched for which may be related directly to the matter constituting the neutron star core. In this work, the physics goals, the experimental design, and expected physics results of J-PARC-HI will be discussed.

Major and trace element geochemistry of Lake Bogoria and Lake Nakuru, Kenya, during extreme draught.

PubMed

Jirsa, Franz; Gruber, Martin; Stojanovic, Anja; Omondi, Steve Odour; Mader, Dieter; Körner, Wilfried; Schagerl, Michael

2013-10-01

The physico-chemical properties of water samples from the two athalassic endorheic lakes Bogoria and Nakuru in Kenya were analysed. Surface water samples were taken between July 2008 and October 2009 in weekly intervals from each lake. The following parameters were determined: pH, salinity, electric conductivity, dissolved organic carbon (DOC), the major cations (FAAS and ICP-OES) and the major anions (IC), as well as certain trace elements (ICP-OES). Samples of superficial sediments were taken in October 2009 and examined using Instrumental Neutron Activation Analysis (INAA) for their major and trace element content including rare earth elements (REE). Both lakes are highly alkaline with a dominance of Na > K > Si > Ca in cations and HCO 3  > CO 3  > Cl > F > SO 4 in anions. Both lakes also exhibited high concentrations of Mo, As and fluoride. Due to an extreme draught from March to October 2009, the water level of Lake Nakuru dropped significantly. This created drastic evapoconcentration, with the total salinity rising from about 20‰ up to 63‰. Most parameters (DOC, Na, K, Ca, F, Mo and As) increased with falling water levels. A clear change in the quality of DOC was observed, followed by an almost complete depletion of dissolved Fe from the water phase. In Lake Bogoria the evapoconcentration effects were less pronounced (total salinity changed from about 40‰ to 48‰). The distributions of REE in the superficial sediments of Lake Nakuru and Lake Bogoria are presented here for the first time. The results show a high abundance of the REE and a very distinct Eu depletion of Eu/Eu* = 0.33-0.45.

Major and trace element geochemistry of Lake Bogoria and Lake Nakuru, Kenya, during extreme draught

PubMed Central

Jirsa, Franz; Gruber, Martin; Stojanovic, Anja; Omondi, Steve Odour; Mader, Dieter; Körner, Wilfried; Schagerl, Michael

2013-01-01

The physico-chemical properties of water samples from the two athalassic endorheic lakes Bogoria and Nakuru in Kenya were analysed. Surface water samples were taken between July 2008 and October 2009 in weekly intervals from each lake. The following parameters were determined: pH, salinity, electric conductivity, dissolved organic carbon (DOC), the major cations (FAAS and ICP-OES) and the major anions (IC), as well as certain trace elements (ICP-OES). Samples of superficial sediments were taken in October 2009 and examined using Instrumental Neutron Activation Analysis (INAA) for their major and trace element content including rare earth elements (REE). Both lakes are highly alkaline with a dominance of Na > K > Si > Ca in cations and HCO3 > CO3 > Cl > F > SO4 in anions. Both lakes also exhibited high concentrations of Mo, As and fluoride. Due to an extreme draught from March to October 2009, the water level of Lake Nakuru dropped significantly. This created drastic evapoconcentration, with the total salinity rising from about 20‰ up to 63‰. Most parameters (DOC, Na, K, Ca, F, Mo and As) increased with falling water levels. A clear change in the quality of DOC was observed, followed by an almost complete depletion of dissolved Fe from the water phase. In Lake Bogoria the evapoconcentration effects were less pronounced (total salinity changed from about 40‰ to 48‰). The distributions of REE in the superficial sediments of Lake Nakuru and Lake Bogoria are presented here for the first time. The results show a high abundance of the REE and a very distinct Eu depletion of Eu/Eu* = 0.33–0.45. PMID:25843965