Out of (South) Africa: Pretoria`s nuclear weapons experience. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horton, R.E.

1998-04-01

The primary focus of this paper is the impact of key South African leaders on the successful developments and subsequent rollbacks of South Africa`s nuclear weapons capability. It highlights the key milestones in the development of South Africa`s nuclear weapon capability. It also relates how different groups within South Africa (scientists, politicians, military and technocrats) interacted to successfully produce South Africa`s nuclear deterrent. It emphasizes the pivotal influence of the senior political leadership to pursue nuclear rollback given the disadvantages of its nuclear means to achieve vital national interests. The conclusions drawn from flu`s effort are the South African nuclearmore » program was an extreme response to its own identity Crisis. Nuclear weapons became a means to achieving a long term end of a closer affiliation with the West. A South Africa yearning to be identified as a Western nation and receive guarantees of its security rationalized the need for a nuclear deterrent. The deterrent was intended to draw in Western support to counter a feared total onslaught by Communist forces in the region. Two decades later, that same South Africa relinquished its nuclear deterrent and reformed its domestic policies to secure improved economic and political integration with the West.« less

Nuclear deterrence in the Arab-Israeli conflict. A case study in Egyptian-Israeli relations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shikaki, K.I.

1986-01-01

In order to achieve security and stability, and maximize the chances for resolving the Arab-Israeli conflict, should Egypt and Israel adopt declared nuclear deterrence doctrines. Or would such a move be ineffective, dangerous, or even disastrous. The nuclearization of the Middle East is not necessary: military threats to the survival of the states in the region do not justify the introduction of nuclear weapons. Nuclearization is not desirable: deterrence theory's assumptions and implications exhibit intellectual weakness and its explanatory power is unsatisfactory; nuclear deterrence may reduce the frequency of war, but it pays little attention to the consequences of war;more » and in comparison to defense, nuclear deterrence may lack credibility. Presently, Israel has nuclear capability and delivery systems sufficient to provide security to its vital areas through deterrence of or defense against Arab attacks. The Arabs do not, however, believe that such security extends to the Arab territories occupied by Israel during the June 1967 war. To supply security, nuclear deterrence must be effective, stable, and credible. In a multinuclear environment, the Egyptians and Israelis are likely to meet the requirement for an effective deterrence: the possession of a nuclear capability sufficient to inflict an enormous amount of death and destruction. If the Arabs and Israelis sought and adopted strategies of deterrence, they might be able to meet the requirement for a stable deterrence: the acquisition of second strike capabilities.« less

The role of opacity and transparency in achieving strategic stability in South Asia.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rajain, Arpit; Ashraf, Tariq Mahmud

According to international relations theory, deterrence can be used as a tool to achieve stability between potentially hostile nations. India and Pakistan's long history of periodic crises raises the question of how they can achieve deterrence stability. 'Transparency' describes the flow of information between parties and plays a key role in establishing a deterrence relationship. This paper studies the balance needed between opacity and transparency in nuclear topics for the maintenance of deterrence stability between India and Pakistan. States with nuclear weapons are postulated to implement transparency in four categories: potential, capability, intent, and resolve. The study applies these categoriesmore » to the nuclear components of the ongoing India-Pakistan Composite Dialogue Working Group for Peace and Security including CBMs. To focus our efforts, we defined four scenarios to characterize representative strategic/military/political conditions. The scenarios are combinations of these two sets of opposite poles: competition - cooperation; extremism - moderation (to be understood primarily in a religious/nationalistic sense). We describe each scenario in terms of select focal areas (nuclear doctrine, nuclear command and control, nuclear stockpile, nuclear delivery/defensive systems, and conventional force posture). The scenarios help frame the realm of possibilities, and have been described in terms of expected conditions for the focal areas. We then use the conditions in each scenario to prescribe a range of information-sharing actions that the two countries could take to increase stability. We also highlight the information that should not be shared. These actions can be political (e.g., declarations), procedural (e.g., advance notice of certain military activities), or technologically based (e.g., seismic monitoring of the nuclear test moratorium).« less

Nuclear Deterrence. Applications of Elementary Probability to International Relations. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Unit 327.

ERIC Educational Resources Information Center

Smith, Harvey A.

This module is designed to apply mathematical models to nuclear deterrent problems, and to aid users in developing enlightened skepticism about the use of linear models in stability analyses and long-term predictions. An attempt is made at avoiding overwhelming complexities through concentration on land-based missile forces. It is noted that after…

Military Review, February 1992. Volume 72, Number 2

DTIC Science & Technology

1992-02-01

these in turn become fac- tors for Army doctrine. The new strategy has four foundations: nuclear deterrence, forward presence, crisis response and...Today, a select group of officers at Fort mands of the nation. I encourage you to join the Leavenworth is leading the effort to revise US discussion by... Group ; deputy commandant of the US Army Command and General Staff College, For Leavenworth, Kansas: and commanding general, Ist Infantry Division

Strategic Studies Quarterly. Volume 7, Number 1, Spring 2013

DTIC Science & Technology

2013-01-01

John Blake Publishing, 2000). 17. John Sutherland, "Gospels of Hate that Slip through the Net," Guardian (UK), 3 April 2000, http...first deterrence logic properly emphasized what might happen if a crisis slipped out of control: mutual destruc- tion or death and mayhem, all out...official Elaine Bunn’s perceptual metaphor likening B61 withdrawal to removing a wedding ring .) The crucial psychology in all these examples is not that

Crisis Relocation and Nuclear Deterrence

DTIC Science & Technology

1986-04-07

Publications, 1984 ’Virginia mock nuclear disaster simulated in Nevada not as disastrous as feared.’ May 10, 1983, Section C, p.Sa. The Organization of the...Relocation’ Plan" New York Times Magazine, Volume 131: No. 45,347, Jun 1982, p. 16. Deen, Thalif and Earl S. Browning. How to Survive a Nuclear ... Disaster . Piscataway, N.J.: New Century Press, 1981. Group for the Advancement of Psychiatry. Psychiatric Aspects of the Prevention of Nuclear War. New York

The Israeli Nuclear Alert of 1973: Deterrence and Signaling in Crisis

DTIC Science & Technology

2013-04-01

limiting war, see Shlomo Aronson, Conflict and Bargaining in the Middle East (Baltimore: The Johns Hopkins University Press, 1978), 178-9; Shlomo Aronson...Ismail Fahmy, Negotiating for Peace in the Middle East (Baltimore: The Johns Hopkins University Press, 1983), 24-7. Indeed, Evron points out that...attaché. Yair Evron offered a similar report in Israel’s Nuclear Dilemma, 72. 50. See, for instance, Walter Boyne , The Two O’Clock War: The 1973 Yom

Parameters: US Army War College Quarterly. Volume 21. Number 1. Spring 1991

DTIC Science & Technology

1991-01-01

continuing deterrence and immediate crisis response. Notwithstanding the dramatic growth in US trade in the Pacific Basin, with a corresponding increase ...warning time or, as I would prefer to call it, "available response time," is truly increasing with respect to any future conflict in Europe, that fact...posture, readiness levels, and other Cold War defense burdens. Increased warning time will be a curse, however, if it lulls us and our alliance partners

What Happens to Deterrence as Nuclear Weapons Decrease Toward Zero?

NASA Astrophysics Data System (ADS)

Drell, Sidney

2011-04-01

Steps reducing reliance on deployed nuclear weapons en route to zero will be discussed. They include broadly enhancing cooperation and transparency agreements beyond the provisions for verifying limits on deployed strategic nuclear warheads and delivery systems in the New START treaty. Two questions that will be addressed are: What conditions would have to be established in order to maintain strategic stability among nations as nuclear weapons recede in importance? What would nuclear deterrence be like in a world without nuclear weapons?

Can We Deter Terrorists From Employing Weapons of Mass Destruction on the U.S. Homeland?

DTIC Science & Technology

2003-04-01

come to think of al Qaeda like a strawberry plant that sends out runners forming roots where they touch the ground to spawn new plants. These new plants...technicians, and Islamic charities. Individual successes at the operational and tactical level can also have a chilling effect on recruitment and...Some believe the U.S. faces its greatest WMD threat since the 1962 Cuban missile crisis, but many discount the effect deterrence can have on terrorist

Preference and aversion for deterrent chemicals in two species of Peromyscus mouse.

PubMed

Glendinning, J I

1993-07-01

Deterrent chemicals such as quinine hydrochloride (QHC1) are generally considered to be aversive to mammals at all detectable concentrations. However, several species contain individuals that drink solutions containing low concentrations of deterrents in preference to plain water. The present study examines this paradoxical preference in two species of mouse, Peromyscus melanotis and P. aztecus. Preliminary findings had suggested that whereas some P. aztecus prefer low concentrations of QHC1, no P. melanotis prefer any concentration of QHC1. Experiment 1 tested the hypothesis that individual mice that prefer low concentrations of QHC1 would respond similarly to four other deterrents described by humans as bitter and/or astringent (ouabain, hop extract, sucrose octaacetate, and tannic acid) in 48-h, two-bottle choice tests. Peromyscus aztecus displayed a large amount of intraspecific variation in response to all five deterrents. Those P. aztecus that drank low concentrations of QHC1 in preference to plain water were significantly more likely to respond similarly to low concentrations of the other deterrents. No P. melanotis displayed a preference for any concentration of either deterrent. Experiment 2 examined the temporal stability of the response to 0.1 mM QHC1 in P. aztecus over six consecutive choice tests. Mice were divided into three groups based on their initial response to the QHC1 solution (preference, no response, or rejection) and then subjected to the 12-day test. The response of mice within each of the groups did not change significantly over time.(ABSTRACT TRUNCATED AT 250 WORDS)

Weapons of mass destruction in the developing world. What are the operational options. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minner, D.K.

1992-06-19

The proliferation in quantity and quality of weapons of mass destruction serve as a threat of great consequence to U.S. operational forces. Operational options for action are explored within the national military strategy concepts of forward presence, deterrence, and crisis/regional contingency response. Three questions and associated issues related to operational art are posed for each concept: (1) what condition must be produced to achieve the strategic goal, (2) what events will most likely result in the desired condition, and (3) how should resources be applied to produce those events. The resulting analysis offers the following conclusions: (1) complementary efforts bymore » all instruments of national power--political, diplomatic, economic, and military--are necessary; (2) knowledge, training, and equipment are the first line of defense; (3) persuasion as well as confrontation is necessary; (4) effective deterrence requires capability, credibility, and communication; and (5) training and weapons for retaliation-in-kind remain the final alternative.« less

Joseph A. Burton Forum Award: Some Nuclear Weapons Dilemmas

NASA Astrophysics Data System (ADS)

May, Michael

2014-03-01

Nuclear weapons pose a combination of political and ethical dilemmas the solution to which has not been found. On one hand, in the view of both US government leaders and US allies, nuclear deterrence continues to play an essential part in the US role as the ultimate source of military strength for the alliances among the major democratic countries. It also continues to be in demand by countries that believe themselves to be isolated and threatened. On the other hand, nuclear weapons, besides being effective deterrents, can cause unprecedented loss of life and risk the demise of civilizations. No ban or technical precaution could prevent the rebuilding of nuclear weapons in a crisis. No diplomatic arrangement to date has erased the threat of invasion and war in the world. Only the abandonment of war and the threat of war as instruments of policy can make nuclear weapons obsolete. The slow, halting, risky road to that end remains the only hope for a world in which lasting solutions to the nuclear dilemmas are possible.

Scientific impacts on nuclear strategic policy: Dangers and opportunities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keeny S.M. Jr.

1988-12-15

Nuclear weapons have revolutionized warfare, making a mutual capability for assured destruction a fact of life and mutual assured deterrence the underlying nuclear strategy of the superpowers. The program to find a technical solution to the threat of nuclear weapons by creating an impervious defense is fatally flawed by failure to consider responses available to a sophisticated adversary at much lower cost. Responses could involve: exploiting vulnerabilities; increased firepower; technical innovation; and circumvention. Efforts to achieve strategic defense would in fact increase risk of nuclear war by stimulating the nuclear arms race since history demonstrates neither side will allow itsmore » deterrent force to be seriously degraded. Defenses would increase instability in times of a crisis. Science has also reduced the risk of nuclear war by making possible improved control and safety of nuclear forces and predictability of US/Soviet relations, verifiability of arms control agreements, and survivable strategic systems. Science can be a tool for good or evil; mankind must be its masters not its slaves.« less

Scientific impacts on nuclear strategic policy: Dangers and opportunities

NASA Astrophysics Data System (ADS)

Keeny, Spurgeon M.

1988-12-01

Nuclear weapons have revolutionized warfare, making a mutual capability for assured destruction a fact of life and mutual assured deterrence the underlying nuclear strategy of the superpowers. The program to find a technical solution to the threat of nuclear weapons by creating an impervious defense is fatally flawed by failure to consider responses available to a sophisticated adversary at much lower cost. Responses could involve: exploiting vulnerabilities; increased firepower; technical innovation; and circumvention. Efforts to achieve strategic defense would in fact increase risk of nuclear war by stimulating the nuclear arms race since history demonstrates neither side will allow its deterrent force to be seriously degraded. Defenses would increase instability in times of a crisis. Science has also reduced the risk of nuclear war by making possible improved control and safety of nuclear forces and predictability of US/Soviet relations, verifiability of arms control agreements, and survivable strategic systems. Science can be a tool for good or evil; mankind must be its masters not its slaves.

Nonoffensive defense is overrated

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flanagan, S.J.

1988-09-01

Some Western analysts argue that European security would stabilize if nations shifted to forces and doctrines that left them structurally incapable of conducting offensive military actions. Some, including American scholar Gene Sharp, have even called for replacing traditional military forces with plans for civilian-based resistance. Purely defensive postures would be reassuring to neighboring states, all of these theorists say, but such defenses would still be strong enough to defeat an attack if deterrence failed. This defensive-only stance, according to its advocates, is a purer form of deterrence by denial than now exists, since it removes even the possibility of inflictingmore » punishment in retaliation for an attack: it deters only be denying victory. But Mr. Flanagan questions whether such defense actually would serve as a credible deterrent. In addition, the various proposed schemes share some serious weaknesses, which he proceeds to discuss. 5 refs.« less

Thermonuclear peace, the tightrope of deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Uscher, A.R.

This policy analysis focuses on the actions and approaches that will best reduce the chances of nuclear war in a MAD world, where mutual terror and mutual dependence will define our bipolar environment for the foreseeable future. The general approach to this broad and complex issue can be summarized as follows: since plans for conducting and preventing nuclear war are likely to be self-fulfilling prophecies, the US should strive for rational declaratory and deployment policies that reduce the chance of nuclear conflict while maintaining our national-security interests. Stability, probably the single most-important and unifying theme in nuclear deterrence, is visualizedmore » as a set of incentive structures that create no perceived advantages in escalating at any point along a hypothetical-force continuum. The key element in establishing and maintaining superpower stability is the inability to achieve adequate damage limitation through a preemptive first strike. The power and number of nuclear weapons compared to the fragility and limited number of priority targets seriously challenge the utility of most defensive measures. Successfully walking the tightrope of deterrence will require careful balancing of legitimate and competing values. This is a difficult task, but with a clear and realistic vision of the future, it is a feasible one.« less

Racial/ethnic minority children's use of psychiatric emergency care in California's Public Mental Health System.

PubMed

Snowden, Lonnie R; Masland, Mary C; Libby, Anne M; Wallace, Neal; Fawley, Kya

2008-01-01

We examined rates and intensity of crisis services use by race/ethnicity for 351,174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits.

Coping with mass destruction: United States power projection in the nuclear and chemical third world. Monograph report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheek, G.H.

1993-05-14

This monograph explores the proliferation of weapons of mass destruction in the Third World, their operational impact on power projection forces, and the viability of deterrence in the future. It concludes that the proliferation of weapons of mass destruction may have grave consequences for the power projection forces in the future; simple assumptions of non-use, reliance on our nuclear deterrent or protective measures may give us a false sense of security. Proper analysis of operational vulnerabilities will be essential for future power projection. Proliferation of operational delivery systems and weapons of mass destruction continues despite treaties and the best intentionsmore » of world leaders. Weapons of mass destruction are becoming more common throughout the world and chemical and biological weapons continue to become more and more lethal. These trends are creating a multipolar world, which history has shown to be the most unstable. This unstable world will be the environment for future power projection. Deterrence in this environment is without precedent other than the Cold War paradigm. It is questionable whether deterrence will transfer outside this paradigm as Third World nations do not have the experience, balance of power, infrastructure or political stability needed to make the concept viable. Possession of weapons of mass destruction may even allow these nations to deter entry of US power projection forces into certain regions as deterrence is a two way concept. While deterrence is still an essential part of US National Strategy to prevent war, reliance on it to prevent use of weapons of mass destruction in the midst of a conflict may prove to be a false hope.« less

Deaths in the desert: the human rights crisis on the U.S.-Mexico border.

PubMed

Androff, David K; Tavassoli, Kyoko Y

2012-04-01

Many would acknowledge that immigration is a major issue in the United States and that immigration reform should be a priority. However, there is little attention to the human rights crisis on the U.S.-Mexican border. As a result of tightened border security since 1994, it is estimated that over 5,000 migrants have died in the Sonoran desert. The criminalization of immigration has resulted in a human rights crisis in three areas: (1) the rise of deaths and injuries of migrants crossing the border in harsh and remote locations, (2) the use of mass hearings to prosecute apprehended migrants, and (3) abuses of migrants in immigration detention. These policies and practices have serious repercussions for the affected vulnerable population. Despite recent legislation designed to discourage undocumented immigration, such as Arizona's Senate Bill 1070, the deterrence strategy has not diminished migration--it has only increased the suffering and deaths of migrants. Humanitarian groups are working to prevent more deaths but also have been targeted for criminalization. The profession's ethics compel social workers to work with humanitarian organizations to prevent more deaths and to advocate for humane immigration reform.

AMERICA’S BASE NETWORK: CREDIBLE DETERRENCE

DTIC Science & Technology

2017-04-06

reduction occurring after World War I.13 Both eras saw decades of instability and warfare replace the economic stability provided by the US and its global...is still in effect today and is based on shared interests in security and stability . The alliance was formally established via an Economic and...Abstract This essay looks at historical US basing strategy in order to understand the geopolitical and economic complexity facing diplomacy of future

Do Crisis Response Operations Affect Political and Economic Stability?

DTIC Science & Technology

2003-05-01

military presence itself actually affects overall levels of political and economic stability is still an open question. We look at the following two...relationship between military actions and political and economic stability . In this paper, we focus only on the crisis response piece of the overseas presence issue.

We all lost the Cold War

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebow, R.N.; Stein, J.G.

1994-12-31

The purpose of the book is to use the experience of two actual Cold War crises to test the hypothesis that it was the U.S. strategy of deterrence that was primarily responsible for preventing war with the Soviet Union and teaching them that aggression would not pay. The two crises; the Cuban missile crisis of 1962 and the Middle East crisis of 1973 have been widely interpreted as victories for U.S. deterence strategy. The authors draw on sources that were previously unavailable, both documents and interviews. The authors show that it was the fear of any nuclear use, not quantitativemore » assessments of the nuclear balance, that deterred both Soviet and American leaders in the two crises examined. Each side believed that the loss of even a single city was unacceptable. This implies that the benefits of nuclear weapons derive from their ability to annihilate cities. A policy of finite deterence would rely almost exclusively on this threat to civilians, raising further moral questions.« less

The New Era of Counterforce

NASA Astrophysics Data System (ADS)

Lieber, Keir

Nuclear deterrence rests on the survivability of nuclear arsenals. For much of the nuclear age, counterforce disarming attacks those aimed at eliminating nuclear forces were nearly impossible because of the ability of potential victims to hide and protect their weapons. However, technological developments are eroding this foundation of nuclear deterrence. Advances rooted in the computer revolution have made nuclear forces around the world far more vulnerable than before. Specifically, two key approaches that countries have relied on to ensure arsenal survivability since the dawn of the nuclear age hardening and concealment have been undercut by leaps in weapons accuracy and a revolution in remote sensing. Various models, methods, and evidence demonstrate the emergence of new possibilities for counterforce disarming strikes. In short, the task of securing nuclear arsenals against attack is a far greater challenge than it was in the past. The new era of counterforce challenges the basis for confidence in contemporary deterrence stability, raises critical issues for national and international security policy, and sheds light on one of the enduring theoretical puzzles of the nuclear era: why international security competition has endured in the shadow of the nuclear revolution.

Unconventional Deterrence Strategy

DTIC Science & Technology

2005-06-01

200 words) This thesis examines a largely unexplored area of deterrence theory – unconventional deterrence. Unconventional deterrence is defined...hypothesis of deterrence theory which says that the balance of the opponents’ military capabilities is the basic determinant of successful deterrence...

Litigation and complaints procedures: objectives, effectiveness and alternatives.

PubMed Central

Whelan, C J

1988-01-01

Recent debates about redress mechanisms for medical accident victims have been sidetracked by fears of an American-style medical malpractice crisis. What is required is a framework within which the debate can resume. This paper proposes such a framework by focusing on the compensation and deterrence objectives and placing them in the wider context of the social costs of providing medical services. The framework is then used to assess and compare the effectiveness of differing approaches. In particular, the American and British experiences of litigation, including the concept of 'defensive medicine', are evaluated. Also discussed briefly are alternatives to court-based complaints procedures including 'no-fault' schemes, professional ethics and internal complaints mechanisms. PMID:3392721

Secular trends in opioid prescribing in the USA.

PubMed

Pezalla, Edmund J; Rosen, David; Erensen, Jennifer G; Haddox, J David; Mayne, Tracy J

2017-01-01

Opioid abuse and misuse in the USA is a public health crisis. The use of prescription opioid analgesics increased substantially from 2002 through 2010, then plateaued and began to decrease in 2011. This study examined prescriptions of branded and generic immediate- and extended-release opioid analgesics from 1992 to 2016. This was juxtaposed against state and federal policies designed to decrease overutilization and abuse, as well as the launch of new opioid products, including opioids with abuse-deterrent properties (OADPs). The data indicate that these health policies, including the utilization and reimbursement of OADPs, have coincided with decreased opioid utilization. The hypothesis that OADPs will paradoxically increase opioid prescribing is not supported.

An Analysis of Secondary Schools' Crisis Management Preparedness: National Implications

ERIC Educational Resources Information Center

Adams, Cheantel M.; Kritsonis, William Allan

2006-01-01

The purpose of this study is to analyze crisis management plans of schools that have experienced crisis situations in the past. The plans used by these schools to manage these crisis situations will be evaluated for their effectiveness or ineffectiveness in re-establishing stability to their organization. With such information, other schools may…

Models for financial crisis detection in Indonesia based on M1, M2 per foreign exchange reverse, and M2 multiplier indicators

NASA Astrophysics Data System (ADS)

Sugiyanto; Zukhronah, Etik; Pratiwi, Esteti Sophia

2017-12-01

Indonesia has been hit by financial crisis in the middle of 1997. The financial crisis that has occurred gives a severe impact to the economy of Indonesia resulting the needs for a detection system of financial crisis. Crisis can be detected based on several indicators such as M1, M2 per foreign exchange reserves, and M2 multiplier. These three indicators can affect the exchange rate stability and may further affect the financial stability so that it can be one of the causes of the financial crisis. This research aims to determine the appropriate model that can detect the financial crisis in Indonesia. Markov switching is an alternative model that can be approach and used often for detecting financial crisis. We can determine the combination of volatility and Markov switching model with AR and volatility model are determined first. The results of this research are that M1 can be modelled by SWARCH (3, 1) while M2 per foreign research exchange reserves and M2 multiplier can be modelled by SWARCH(3,2).

Deterrence and Engagement: A Blended Strategic Approach to a Resurgent Russia

DTIC Science & Technology

2016-04-15

Expansionism “If you know the enemy and know yourself, you need not fear the result of a hundred battles.” – Sun Tzu , The Art of War. An analysis...55 Bibliography ...the U.S. and its European allies, could achieve greater stability and security for Europe. 57 Bibliography Adamsky, Dmitry. “If War Comes

75 FR 69871 - Homeowners Assistance Program-Application Processing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-16

... relocating during the mortgage crisis; and Service member homeowners undergoing Permanent Change of Station (PCS) moves during the mortgage crisis. DATES: Effective Date: January 18, 2011. FOR FURTHER... financial stability and increase quality of life for those impacted by the mortgage crisis. The Department...

Impact of emotional stability and attitude on consumption decisions under risk: the Coca-Cola crisis in Belgium.

PubMed

Verbeke, Wim; Van Kenhove, Patrick

2002-01-01

This article focuses on consumer reactions during and after the Coca-Cola crisis of June 1999 in Belgium. The research tests for associations between the personality trait "emotional stability," attitude toward the brand, and self-reported behavior. Cross-sectional data are collected from a sample of Coca-Cola drinkers between 19 and 22 years old. The data are analyzed through the specification and estimation of a structural equation model and ANOVA. A direct and positive effect of attitude toward the brand on the behavioral response is found. No direct effect of emotional stability on behavior is revealed. However, indirect effects of personality mediated by attitude are discovered. Further, emotional stability is found to correlate negatively with importance attached to information during the crisis. Fast and transparent communication with specific attention to lower emotional stability groups, as well as the inclusion of personality and attitude measurements in future health and food safety studies, are recommended.

Stability and change in political conservatism following the global financial crisis.

PubMed

Milojev, Petar; Greaves, Lara; Osborne, Danny; Sibley, Chris G

2015-01-01

The current study analyzes data from a national probability panel sample of New Zealanders (N = 5,091) to examine stability and change in political orientation over four consecutive yearly assessments (2009-2012) following the 2007/2008 global financial crisis. Bayesian Latent Growth Modeling identified systematic variation in the growth trajectory of conservatism that was predicted by age and socio-economic status. Younger people (ages 25-45) did not change in their political orientation. Older people, however, became more conservative over time. Likewise, people with lower socio-economic status showed a marked increase in political conservatism. In addition, tests of rank-order stability showed that age had a cubic relationship with the stability of political orientation over our four annual assessments. Our findings provide strong support for System Justification Theory by showing that increases in conservatism in the wake of the recent global financial crisis occurred primarily among the poorest and most disadvantaged.

Establishing "abuse-deterrence equivalence" for generic abuse-deterrent opioid formulations: A proposed development framework.

PubMed

Setnik, Beatrice; Cone, Edward J

2016-01-01

Abuse-deterrent formulations are one strategy for mitigating the epidemic of prescription opioid abuse. Regulatory guidance documents describe the requirements for developing abuse-deterrent formulations of novel drugs and formulations; however, they do not address "abuse-deterrence equivalence" for generic formulations. As generics may be produced with different excipients and formulations compared to reference drugs, differences in their properties may impact their abuse-deterrent features. Currently, it is unclear what specific studies are needed to support generic abuse-deterrence claims. This commentary outlines several recommendations on the in vitro and in vivo testing required, including the conditions for conducting a human abuse potential study.

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 6. South Korean Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-04-11

8217IN.2 AD-A166 115 DNA-TR-84-109-V6 ’’ WEST EUROPEAN AND EAST ASIAN PERSPECTIVES ON DEFENSE, DETERRENCE AND STRATEGY Volume VI-South Korean Perspectives...on Defense, Deterrence and J. Strategy Institute for Foreign Policy Analysis Central Plaza Building 675 Massachusetts Avenue Cambridge, MA 02139...PERSPECTIVES ON DEFENSE, DETERRENCE AND STRATEGY Volume VI-South Korean Perspectives on Defense, Deterrence and Strategy 12 PERSONALAUTHOR(S

A Comparative Analysis of Unit Cohesion in Vietnam

DTIC Science & Technology

2014-06-13

the political process, and result in a communist government; this became known as the Domino Theory . The United States replaced the French and...a theory of linkage; leveraging the political ties of Communist countries, namely the USSR and China, to influence North Vietnam, and deterrence; a...and Henderson provide some of the more popular theories about cohesion. Winkler points out that the relationship between stability, cohesion and

Conventional Expeditionary Forces: A 21st Century Triad for Strategic Deterrence

DTIC Science & Technology

2009-05-27

testing and transfers of nuclear materials, the ability to effectively monitor and track all such activities 100% of the time does not exist at present nor...Limited Test Ban Treaty of 1963 sought to stabilize the arms race and reduce environmental damage by banning atmospheric, sea-based, and space-based...nuclear weapons tests , thereby limiting future testing to underground conditions, and was signed 139

Affect intensity and processing fluency of deterrents.

PubMed

Holman, Andrei

2013-01-01

The theory of emotional intensity (Brehm, 1999) suggests that the intensity of affective states depends on the magnitude of their current deterrents. Our study investigated the role that fluency--the subjective experience of ease of information processing--plays in the emotional intensity modulations as reactions to deterrents. Following an induction phase of good mood, we manipulated both the magnitude of deterrents (using sets of photographs with pre-tested potential to instigate an emotion incompatible with the pre-existent affective state--pity) and their processing fluency (normal vs. enhanced through subliminal priming). Current affective state and perception of deterrents were then measured. In the normal processing conditions, the results revealed the cubic effect predicted by the emotional intensity theory, with the initial affective state being replaced by the one appropriate to the deterrent only in participants exposed to the high magnitude deterrence. In the enhanced fluency conditions the emotional intensity pattern was drastically altered; also, the replacement of the initial affective state occurred at a lower level of deterrence magnitude (moderate instead of high), suggesting the strengthening of deterrence emotional impact by enhanced fluency.

The Future of US Nuclear Deterrence and the Impact of the Global Zero Movement

DTIC Science & Technology

2013-02-10

The most appealing GZC recommendation is for a de facto minimum deterrence model en route to GZ. To its detriment, however, the GZC proposal relies...difficult to dispute that this path leads, at least eventually, to a minimum deterrence model . It is likely that the US can continue to wield a...instead, a capable, credible deterrent is critical to countering these threats and is especially so in a minimum deterrence model . Two key

Current and Future Challenges for Asian Nonproliferation Export Controls: A Regional Response

DTIC Science & Technology

2004-10-01

degree of financial interdependence was evidenced by the 1997 financial crisis, which resulted in the Chiang Mai + 3 Initiative.ř Intra-company trade...financial crisis, the finance ministers of ASEAN+3 countries (China, Japan, and South Korea) reached agreement on the " Chiang Mai Initiative," which...stability. The Chiang Mai Initiative has contributed to improving exchange rate stability and in doing so may also have contributed to closer regional

Legal liability perspectives on abuse-deterrent opioids in the treatment of chronic pain.

PubMed

Brushwood, David B; Rich, Ben A; Coleman, John J; Bolen, Jennifer; Wong, Winston

2010-12-01

Abuse-deterrent opioid analgesic formulations can help reduce the risk of opioid diversion and abuse. Not all opioid analgesics are available as both extended- and immediate-release dosage forms in abuse-deterrent formulations. Clinicians may have to balance the clinical benefit of a product that does not use abuse-deterrent technology versus the regulatory benefit of using a product with this technology. There is the possibility that a health care professional may be held legally liable when a product without abuse-deterrent qualities is used and a person suffers harm that would not have occurred had an abuse-deterrent formulation been provided. This article reviews legal precedents that inform an understanding of the need to reduce malpractice exposure by identifying patients who are at high risk of opioid diversion and/or abuse and considering the use of an abuse-deterrent formulation for these patients.

The Relationship between Caregiver Capacity and Intensive Community Treatment for Children with a Mental Health Crisis

ERIC Educational Resources Information Center

Epstein, Richard A.; Jordan, Neil; Rhee, Yong Joo; McClelland, Gary M.; Lyons, John S.

2009-01-01

We studied 9,220 children referred to a comprehensive mental health crisis stabilization program to examine the impact of caregiver capacity on crisis worker decisions to refer children for intensive community-based treatment as opposed to inpatient psychiatric hospitalization. Due to the different role of caregivers in the child welfare system,…

Oviposition Deterrent Activities of Pachyrhizus erosus Seed Extract and Other Natural Products on Plutella xylostella (Lepidoptera: Plutellidae)

PubMed Central

Basukriadi, Adi; Wilkins, Richard M.

2014-01-01

Abstract An extract of a rotenone-containing plant yam bean, Pachyrhizus erosus (L.) Urban, seeds was tested against the diamondback moth, Plutella xylostella (L.) in a greenhouse to determine its potential as an oviposition deterrent and compared with coumarin and rutin, known as diamondback moth oviposition deterrent compounds, rotenone, and an extract of Peruvian cube root, at a concentration of 0.5% (w/v). Oviposition deterrent index (ODI) was used to determine effects of extracts or compounds in inhibiting oviposition of diamondback moth. Coumarin showed a stronger deterrent effect than the yam bean seed extract with a higher ODI value. On the contrary, rotenone, rutin, and the cube root extract, containing 6.7% (w/w) of rotenone, showed no significant deterrent effects having low or negative ODI values, suggesting that the deterrent effect of the yam bean seed extract is not due to rotenone content of the yam bean seeds. The extract of yam bean seed and coumarin partially deterred the moth from laying eggs on treated leaves in a concentration-dependent manner. The effective concentration for 50% deterrency of coumarin and the yam bean seed extract were 0.11 and 0.83% (w/v), respectively. However, the yam bean seed extract showed a residual deterrent effect on the moth even at 3 d after the treatment and is probably because of its low volatile nature. A long-term deterrency of the yam bean seed extract is an advantage over coumarins. Both the yam bean seed extract and coumarin deterred diamondback moth from laying eggs in total darkness, indicating their nonvisual deterrent effect. This made the extract an effective deterrence to diamondback moth in light and in darkness. To conclude, this study revealed the potential of the crude extract of the yam bean seed to prevent diamondback moth from ovipositing on its plant host. PMID:25525107

Oviposition deterrent activities of Pachyrhizus erosus seed extract and other natural products on Plutella xylostella (Lepidoptera: Plutellidae).

PubMed

Basukriadi, Adi; Wilkins, Richard M

2014-01-01

An extract of a rotenone-containing plant yam bean, Pachyrhizus erosus (L.) Urban, seeds was tested against the diamondback moth, Plutella xylostella (L.) in a greenhouse to determine its potential as an oviposition deterrent and compared with coumarin and rutin, known as diamondback moth oviposition deterrent compounds, rotenone, and an extract of Peruvian cube root, at a concentration of 0.5% (w/v). Oviposition deterrent index (ODI) was used to determine effects of extracts or compounds in inhibiting oviposition of diamondback moth. Coumarin showed a stronger deterrent effect than the yam bean seed extract with a higher ODI value. On the contrary, rotenone, rutin, and the cube root extract, containing 6.7% (w/w) of rotenone, showed no significant deterrent effects having low or negative ODI values, suggesting that the deterrent effect of the yam bean seed extract is not due to rotenone content of the yam bean seeds. The extract of yam bean seed and coumarin partially deterred the moth from laying eggs on treated leaves in a concentration-dependent manner. The effective concentration for 50% deterrency of coumarin and the yam bean seed extract were 0.11 and 0.83% (w/v), respectively. However, the yam bean seed extract showed a residual deterrent effect on the moth even at 3 d after the treatment and is probably because of its low volatile nature. A long-term deterrency of the yam bean seed extract is an advantage over coumarins. Both the yam bean seed extract and coumarin deterred diamondback moth from laying eggs in total darkness, indicating their nonvisual deterrent effect. This made the extract an effective deterrence to diamondback moth in light and in darkness. To conclude, this study revealed the potential of the crude extract of the yam bean seed to prevent diamondback moth from ovipositing on its plant host. © The Author 2014. Published by Oxford University Press on behalf of the Entomological Society of America.

Evolution in strategic forces and doctrine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canavan, G.H.

The era of the deterrence through the threat of retaliation is ending. Strategic defense opens new options for deep reductions without loss of stability, which could be a guide for shifting from the residual forces from the offensive era into those appropriate for a multipolar world. There are strong arguments for retiring missiles under the cover of missile defenses and returning to fewer but more capable aircraft for strategic roles. Developing the technologies for theater and strategic defenses could largely eliminate the incentive for the development of missiles by the third world and shift their efforts into more stabilizing areas.more » 20 refs.« less

Games With Estimation of Non-Damage Objectives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canavan, G.H.

1998-09-14

Games against nature illustrate the role of non-damage objectives in producing conflict with uncertain rewards and the role of probing and estimation in reducing that uncertainty and restoring optimal strategies. This note discusses two essential elements of the analysis of crisis stability omitted from current treatments based on first strike stability: the role of an objective that motivates conflicts sufficiently serious to lead to conflicts, and the process of sequential interactions that could cause those conflicts to deepen. Games against nature illustrate role of objectives and uncertainty that are at the core of detailed treatments of crisis stability. These modelsmore » can also illustrate how these games processes can generate and deepen crises and the optimal strategies that might be used to end them. This note discusses two essential elements of the analysis of crisis stability that are omitted from current treatments based on first strike stability: anon-damage objective that motivates conflicts sufficiently serious to lead to conflicts, and the process of sequential tests that could cause those conflicts to deepen. The model used is a game against nature, simplified sufficiently to make the role of each of those elements obvious.« less

Differential Deterrence: Studying Heterogeneity and Changes in Perceptual Deterrence among Serious Youthful Offenders

ERIC Educational Resources Information Center

Loughran, Thomas A.; Piquero, Alex R.; Fagan, Jeffrey; Mulvey, Edward P.

2012-01-01

Perceptual deterrence has been an enduring focus of interest in criminology. Although recent research has generated important new insights about how risks, costs, and rewards of offending are perceived and internalized, there remain two specific limitations to advancing theories of deterrence: (a) the lack of panel data to show whether issues of…

The transition to a deterrence posture more reliant on strategic defenses

NASA Astrophysics Data System (ADS)

Chrzanowski, Paul L.

1988-12-01

Strategic nuclear deterrence is currently based on the overwhelming capability of the arsenals of the two superpowers. Massive damage would be inflicted upon the military forces and industrial capacity of both sides should nuclear war occur and escalation of conflict not be controlled. Nuclear deterrence has fostered a condition of peace in central Europe and an absence of direct conflict between the U.S. and the Soviet Union. However, some question whether deterrence will remain effective into the indefinite future, and should deterrence fail the consequences are grave.

Deterrence and First-Strike Stability in Space: A Preliminary Assessment

DTIC Science & Technology

2010-01-01

Paul Deluca, Andrew Hoehn, Martin Libicki, Karl Mueller, Richard Mesic, David Ochmanek, Chad Ohlandt, Jan Osburg, and Carl Rhodes for their...Positioning System ISR intelligence, surveillance, and reconnaissance LEO low earth orbit MAD mutual assured destruction MILSATCOM military satellite...pp. 10–11. 4 Paul B. Stares, The Militarization of Space: U.S. Policy, 1945–1984, Ithaca, N.Y.: Cornell University Press, 1985, pp. 99–100. In the

A Strategic and Integrated Labor Market Approach: Essential to Overcome the Crisis and to Assist Structural Adjustment

ERIC Educational Resources Information Center

Caspar, Sigried; Hartwig, Ines; Moench, Barbara

2012-01-01

Comparing the papers on the Korean and the U.S. situations leads to interesting conclusions. Cho and Shin argue that the recent crisis did not create huge problems in the labor market because Korea was firstly in a fundamentally sound economic situation and secondly took adequate anti-crisis measures, in particular by stabilizing internal demand.…

Department of Energy: An Organizational Look at Americas Nuclear Deterrent

DTIC Science & Technology

2016-09-01

DEPARTMENT OF ENERGY : AN ORGANIZATIONAL LOOK AT AMERICA’S NUCLEAR DETERRENT GRADUATE RESEARCH PAPER David O. Pabst, Maj, USAF...DEPARTMENT OF ENERGY : AN ORGANIZATIONAL LOOK AT AMERICA’S NUCLEAR DETERRENT GRADUATE RESEARCH PAPER Presented to the Faculty...Panel 2014). Thus, the Department of Energy serves to maintain a credible nuclear deterrent by ensuring a safe, secure, and effective nuclear

Feeding deterrent and growth inhibitory activities of PONNEEM, a newly developed phytopesticidal formulation against Helicoverpa armigera (Hubner)

PubMed Central

Packiam, Soosaimanickam Maria; Baskar, Kathirvelu; Ignacimuthu, Savarimuthu

2014-01-01

Objective To assess the feeding deterrent, growth inhibitory and egg hatchability effects of PONNEEM on Helicoverpa armigera (H. armigera). Methods Five oil formulations were prepared at different ratios to assess the feeding deterrent, growth inhibitory and egg hatchability effects on H. armigera. Results Invariably all the newly formulated phytopesticidal oil formulations showed the feeding deterrent and growth inhibitory activities against H. armigera. The maximum feeding deterrent activity of 88.44% was observed at 15 µL/L concentration of PONNEEM followed by formulation A (74.54%). PONNEEM was found to be effective in growth inhibitory activities and egg hatchability at 10 µL/L concentration. It exhibited statistically significant feeding deterrent activity and growth inhibitory activity compared with all the other treatments. Conclusions PONNEEM was found to be effective phytopesticidal formulation to control the larval stage of H. armigera. This is the first report for the feeding deterrent activity of PONNEEM against H. armigera. This newly formulated phytopesticide was patented in India. PMID:25183105

Ultrasonic Bat Deterrent Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kinzie, Kevin; Rominger, Kathryn M.

The project objective was to advance the development and testing of an Near commercial bat-deterrent system with a goal to increase the current GE deterrent system effectiveness to over 50% with broad species applicability. Additionally, the research supported by this program has provided insights into bat behavior and ultrasonic deterrent design that had not previously been explored. Prior research and development had demonstrated the effectiveness of a commercial-grade, air-powered, ultrasonic bat deterrent to be between 30-50% depending upon the species of bat. However, the previous research provided limited insight into the behavioral responses of bats in the presence of ultrasonicmore » deterrent sound fields that could be utilized to improve effectiveness. A unique bat flight room was utilized to observe the behavioral characteristics of bats in the presence of ultrasonic sound fields. Behavioral testing in the bat flight facility demonstrated that ultrasonic sounds similar to those produced by the GE deterrent influenced the activities and behaviors, primarily those associated with foraging, of the species exposed. The study also indicated that continuous and pulsing ultrasonic signals had a similar effect on the bats, and confirmed that as ultrasonic sounds attenuate, their influence on the bats’ activities and behavior decreases. Ground testing at Wolf Ridge Wind, LLC and Shawnee National Forest assessed both continuous and pulsing deterrent signals emitted from the GE deterrent system and further enhanced the behavioral understanding of bats in the presence of the deterrent. With these data and observations, the existing 4-nozzle continuous, or steady, emission ultrasonic system was redesigned to a 6-nozzle system that could emit a pulsing signal covering a larger air space around a turbine. Twelve GE 1.6-100 turbines were outfitted with the deterrent system and a formal three-month field study was performed using daily carcass searches beneath the 12 turbines. Additionally, a unique 3D bat flight path visualization system was utilized to monitor for and identify any changes in bat activity caused by the operation of the deterrent system. Both the carcass search and flight path visualization data indicated that the pulsed deterrent system was effective, but not more effective, than the steady system tested in prior years. The pulsed deterrent system was effective at reducing bat fatalities by 38% for all species and 54% effective at reducing fatalities if Eastern Red bats were excluded from the data. However, an unanticipated byproduct of the pulsing system was the emission of intermittent water vapor from the deterrent devices due to the air compression process that powered the devices. This water vapor may have altered the ultrasonic signal and obscured the results in an unknown way. While a qualitative analysis of the effect of the water vapor on the deterrent signal had indicated there was not dramatic change in the expected ultrasonic signal, it was not possible to conclusively determine if the pulse signal would have been more effective in the absence of the water vapor.« less

Operational Vigilant Warrior: Conventional Deterrence Theory, Doctrine, and Practice

DTIC Science & Technology

1996-06-01

psychological aspect of retaliation more than the possibility that defensive actions can deny anticipated gains. This definition is insufficient to...nuclear deterrence, conventional deterrence can also be based on eliminating or limiting the adversary’s ability to act. The nature and destructive...conclusions from the theory and evidence presented in the previous chapters. It reviews how conventional deterrence can be improved by exploiting

Deterrence Theory and the Role of Shame in Projected Offending of College Students against a Ban on Alcohol

ERIC Educational Resources Information Center

Kelley, Margaret S.; Fukushima, Miyuki; Spivak, Andrew L.; Payne, David

2009-01-01

In the present study we advance previous research in deterrence theory by examining the perceived deterrent effects of a newly instituted dry policy on a college campus. A survey of 500 full-time undergraduate students between the ages of 18 and 26 was conducted 3 months following the ban on alcohol. Hypotheses are derived from deterrence theory…

ASSESSING THE UNCERTAINTY OF NUCLEAR DETERRENCE

DTIC Science & Technology

2017-04-22

empirical attempts. From both qualitative and quantitative perspectives, this paper finds cause to question the certainty that nuclear deterrence will...suggests nuclear weapons do indeed possess a higher deterrence effect than conventional forces alone. Data from the “ Correlates of War” data set was...certainly do not provide an absolute deterrent against aggression. 16 While nuclear weapons appear to be correlated with a reduction in the occurrences

Deterrence and the Celerity of the Death Penalty: A Neglected Question in Deterrence Research. Discussion Paper No. 532-78.

ERIC Educational Resources Information Center

Bailey, William C.

This paper focuses on the deterrent effect of the celerity of the death penalty on homicide rates. The deterrent effect of both the certainty and the celerity of the death penalty on homicide rates is examined cross-sectionally for States. Multiple measures of execution and homicide are considered, along with various sociodemographic variables, in…

'Lumping it': the hidden denominator of the medical malpractice crisis.

PubMed

Meyers, A R

1987-12-01

In a recent article, Miller has reminded us that medical malpractice litigation is not simply an economic problem which inhibits medical practice and increases health care costs. She argues that it has three broader "societal objectives": reparation, emotional vindication, and deterrence. Viewed in the broader perspective of social values, the Maine data suggest that our current approach to medical malpractice does not perform well. Significant numbers of respondents believe that they have been neither vindicated nor compensated for their own or their relatives' illness, injury, or death; and that they have not had the opportunity to protect others from harm. As Miller suggests in her review of British alternatives to medical malpractice litigation, there may be more efficient and effective means of reparation. There may also be more direct and less costly means to deter incompetent practitioners and vindicate those who are harmed. We shall never discover these alternatives if we view the medical malpractice "crisis" as a simple or straightforward problem of costs of premiums, costs of settlements, and costs of judgments; numerators. Medical malpractice litigation is the expression of deep and highly complicated problems, which cannot be solved or even significantly alleviated by false solutions motivated only by concerns of costs and cost containment. They can be addressed only by careful, thoughtful, and comprehensive analysis.

Phaeochromocytoma [corrected] crisis.

PubMed

Whitelaw, B C; Prague, J K; Mustafa, O G; Schulte, K-M; Hopkins, P A; Gilbert, J A; McGregor, A M; Aylwin, S J B

2014-01-01

Phaeochromocytoma [corrected] crisis is an endocrine emergency associated with significant mortality. There is little published guidance on the management of phaeochromocytoma [corrected] crisis. This clinical practice update summarizes the relevant published literature, including a detailed review of cases published in the past 5 years, and a proposed classification system. We review the recommended management of phaeochromocytoma [corrected] crisis including the use of alpha-blockade, which is strongly associated with survival of a crisis. Mechanical circulatory supportive therapy (including intra-aortic balloon pump or extra-corporeal membrane oxygenation) is strongly recommended for patients with sustained hypotension. Surgical intervention should be deferred until medical stabilization is achieved. © 2013 John Wiley & Sons Ltd.

Continuous exposure to the deterrents cis-jasmone and methyl jasmonate does not alter the behavioural responses of Frankliniella occidentalis

PubMed Central

Egger, Barbara; Spangl, Bernhard; Koschier, Elisabeth Helene

2016-01-01

Behavioural responses of Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), a generalist, cell sap-feeding insect species with piercing-sucking mouthparts, after continuous exposure to two deterrent secondary plant compounds are investigated. We compared in choice assays on bean leaf discs, the settling, feeding, and oviposition preferences of F. occidentalis females that had no experience with the two fatty acid derivatives methyl jasmonate and cis-jasmone before testing (naïve thrips) vs. females that had been exposed to the deterrent compounds before testing (experienced thrips). The thrips were exposed to the deterrents at low or high concentrations for varied time periods and subsequently tested on bean leaf discs treated with the respective deterrent at either a low or a high concentration. Frankliniella occidentalis females avoided settling on the deterrent-treated bean leaf discs for an observation period of 6 h, independent of their previous experience. Our results demonstrate that feeding and oviposition deterrence of the jasmonates to the thrips were not altered by continuous exposure of the thrips to the jasmonates. Habituation was not induced, neither by exposure to the low concentration of the deterrents nor by exposure to the high concentration. These results indicate that the risk of habituation to two volatile deterrent compounds after repeated exposure is not evident in F. occidentalis. This makes the two compounds potential candidates to be integrated in pest management strategies. PMID:26726263

Continuous exposure to the deterrents cis-jasmone and methyl jasmonate does not alter the behavioural responses of Frankliniella occidentalis.

PubMed

Egger, Barbara; Spangl, Bernhard; Koschier, Elisabeth Helene

2016-01-01

Behavioural responses of Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae), a generalist, cell sap-feeding insect species with piercing-sucking mouthparts, after continuous exposure to two deterrent secondary plant compounds are investigated. We compared in choice assays on bean leaf discs, the settling, feeding, and oviposition preferences of F. occidentalis females that had no experience with the two fatty acid derivatives methyl jasmonate and cis -jasmone before testing (naïve thrips) vs. females that had been exposed to the deterrent compounds before testing (experienced thrips). The thrips were exposed to the deterrents at low or high concentrations for varied time periods and subsequently tested on bean leaf discs treated with the respective deterrent at either a low or a high concentration. Frankliniella occidentalis females avoided settling on the deterrent-treated bean leaf discs for an observation period of 6 h, independent of their previous experience. Our results demonstrate that feeding and oviposition deterrence of the jasmonates to the thrips were not altered by continuous exposure of the thrips to the jasmonates. Habituation was not induced, neither by exposure to the low concentration of the deterrents nor by exposure to the high concentration. These results indicate that the risk of habituation to two volatile deterrent compounds after repeated exposure is not evident in F. occidentalis . This makes the two compounds potential candidates to be integrated in pest management strategies.

NATO’s Future Role in Europe: Toward a More Political Alliance in a Stable 1 1/2 Bloc System

DTIC Science & Technology

1990-05-01

response along the entire spectrum of potential aggression. In the event deterrence failed, the stategy called for a controlled, measured response... market economy, and a benign Soviet external policy are not made inevitable simply because they are desir- able. Russia has a long history of...bility and peace. • A mixed relationship, involving a combination of accord and competition, in which stability is achieved through a political

Mechanical Loading for Peripheral Nerve Stabilization and Regeneration

DTIC Science & Technology

2013-04-01

apple delivered within a New Skin liquid bandage will also be applied topically, as a deterrent. This constituted a minor amendment within our IACUC...Vicryl suture and the incision to the skin with 3-0 Prolene monofilament suture. The rat was kept for up to 3 weeks with full access to food and...Spagnoli, D., Gaini, S.M., Tanzi, M.C., Bresolin, N., Gri- moldi, N., and Torrente, Y. Skin -derived stem cells trans- planted into resorbable guides

The Common Sense of Small Nuclear Arsenals

DTIC Science & Technology

2012-01-01

affairs. That pattern is continuing and, therefore, is worth examining. In this article I use structural theory to explain what I call “the com­ mon...deterrence and dis­ suasion and then explain small nuclear arsenals in terms of structural theory , relying most heavily on the effects of socialization...deterrence are particularly useful. Dissuasion and general deterrence share many common elements. Both are rooted in deterrence theory and share an

Habituation in Frankliniella occidentalis to deterrent plant compounds and their blends.

PubMed

Egger, Barbara; Spangl, Bernhard; Koschier, Elisabeth Helene

2014-06-01

Feeding and oviposition deterrence of three secondary plant compounds and their 1:1 blends to adult female Frankliniella occidentalis Pergande (Thysanoptera: Thripidae) and the potential for habituation of the thrips to the pure compounds and the 1:1 blends at various concentrations were investigated. In choice assays, we tested dose-dependent feeding and oviposition deterrence of the two fatty acid derivatives methyl jasmonate and cis -jasmone, the phenylpropanoid allylanisole, and their blends when directly applied to bean leaf discs. The concentration required to reduce the feeding damage by 50% relative to the control treatment (FDC 50 ) was lowest for cis -jasmone and highest for allylanisole. The feeding deterrent effect of both jasmonates was increased when blended with allylanisole. Feeding deterrence and oviposition deterrence were strongly correlated. In no-choice assays conducted over four consecutive days, we discovered that dilutions at low concentrations (FDC 15 ) applied to bean leaves resulted in habituation to the deterrents, whereas no habituation occurred at higher concentrations (FDC 50 ). We observed a tendency that the 1:1 blends reduce the probability that thrips habituate to the deterrent compounds. Our results may be useful in the development of integrated crop protection strategies with the implementation of allelochemicals as pest behaviour-modifying agents.

Abuse-deterrent formulations, an evolving technology against the abuse and misuse of opioid analgesics.

PubMed

Schaeffer, Tammi

2012-12-01

The increased use of opioid pain medication has been mirrored by the increased misuse and abuse of these drugs. As part of a multidisciplinary approach to this epidemic, pharmaceutical companies, with the encouragement of the Food and Drug Administration, have increased the development of abuse-deterrent formulations. While all have the goal of treating pain while mitigating misuse and abuse, there are different technologies utilized to impart the abuse-deterrent properties. The goal of this paper is to review the basis of abuse-deterrent formulations, the different types and approaches of some of the abuse-deterrent products, and their current regulatory status in the USA.

Pheochromocytoma crisis is not a surgical emergency.

PubMed

Scholten, Anouk; Cisco, Robin M; Vriens, Menno R; Cohen, Jenny K; Mitmaker, Elliot J; Liu, Chienying; Tyrrell, J Blake; Shen, Wen T; Duh, Quan-Yang

2013-02-01

Pheochromocytoma crisis is a feared and potentially lethal complication of pheochromocytoma. We sought to determine the best treatment strategy for pheochromocytoma crisis patients and hypothesized that emergency resection is not indicated. Retrospective cohort study (1993-2011); literature review (1944-2011). Tertiary referral center. There were 137 pheochromocytoma patients from our center and 97 pheochromocytoma crisis patients who underwent adrenalectomy from the literature. Medical management of pheochromocytoma crisis; adrenalectomy. Perioperative complications, conversion, and mortality. In our database, 25 patients (18%) presented with crisis. After medical stabilization and α-blockade, 15 patients were discharged and readmitted for elective surgery and 10 patients were operated on urgently during the same hospitalization. None underwent emergency surgery. Postoperatively, patients who underwent elective surgery had shorter hospital stays (1.7 vs 5.7 d, P = 0.001) and fewer postoperative complications (1 of 15 [7%] vs 5 of 10 [50%], P = 0.045) and were less often admitted to the intensive care unit (1 of 15 [7%] vs 5 of 10 [50%], P = 0.045) in comparison with urgently operated patients. There was no mortality. Review of the literature (n = 97) showed that crisis patients who underwent elective or urgent surgery vs emergency surgery had less intraoperative (13 of 31 [42%] vs 20 of 25 [80%], P < 0.001) and postoperative complications (15 of 45 [33%] vs 15 of 21 [71%], P = 0.047) and a lower mortality (0 of 64 vs 6 of 33 [18%], P = 0.002). Management of patients presenting with pheochromocytoma crisis should include initial stabilization of the acute crisis followed by sufficient α-blockade before surgery. Emergency resection of pheochromocytoma is associated with high surgical morbidity and mortality.

Will abuse-deterrent formulations of opioid analgesics be successful in achieving their purpose?

PubMed

Bannwarth, Bernard

2012-09-10

During the last 2 decades, there has been a dramatic increase in the use of strong opioids for chronic non-cancer pain. This increase has been accompanied by a steep increase in abuse, misuse, and both fatal and non-fatal overdoses involving prescription opioids. The situation is already alarming in the US. Prescription opioid-related harm is a complex, multifactorial issue that requires a multifaceted solution. In this respect, formulations of opioid analgesics designed to resist or deter abuse may be a useful component of a comprehensive opioid risk minimization programme. Such formulations have or are being developed. Abuse-resistant opioids include those that use some kind of physical barrier to prevent tampering with the formulation. Abuse-deterrent opioids are not necessarily resistant to tampering, but contain substances that are designed to make the formulation less attractive to abusers. This article focuses on two products intended to deter abuse that were reviewed by the US Food and Drug Administration (FDA). The first (Embeda®) consists of extended-release morphine with sequestered naltrexone, an opioid antagonist that is released if the tablet is compromised by chewing or crushing. Although Embeda® exhibited abuse-deterrent features, its label warns that it can be abused in a manner similar to other opioid agonists. Furthermore, tampering with Embeda® will result in the release of naltrexone, which may precipitate withdrawal in opioid-tolerant individuals. In March 2011, all dosage forms of Embeda® were recalled because the product failed to meet routine stability standards, and its return date to the market is currently unknown. The second product (Acurox®) was intended to be both tamper resistant and abuse deterrent. It consisted of an immediate-release oxycodone tablet with subtherapeutic niacin as an aversive agent and used a gel-forming ingredient designed to inhibit inhalation and prevent extraction of the drug for injection. The new drug application for Acurox® was rejected in 2010 by the FDA because of concerns about the potential abuse-deterrent benefits of niacin. While acknowledging that no one formulation can be expected to deter all types of opioid-abusive behaviours and no product is likely to be abuse proof in the hands of clear and determined abusers, the reductions in abuse these new products would provide may be an incremental step towards safer prescription opioids.

Deterrent effects of mandatory license suspension for DWI conviction

DOT National Transportation Integrated Search

1987-06-01

The present study examined the specific and general deterrent effects of Wisconsin's 1982 law mandating three to six month license suspensions for first-time convicted drinking drivers. Specific deterrence (stopping repeat drinking and driving among ...

Extended Deterrence, Nuclear Proliferation, and START III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Speed, R.D.

2000-06-20

Early in the Cold War, the United States adopted a policy of ''extended nuclear deterrence'' to protect its allies by threatening a nuclear strike against any state that attacks these allies. This threat can (in principle) be used to try to deter an enemy attack using conventional weapons or one using nuclear, chemical, or biological weapons. The credibility of a nuclear threat has long been subject to debate and is dependent on many complex geopolitical factors, not the least of which is the military capabilities of the opposing sides. The ending of the Cold War has led to a significantmore » decrease in the number of strategic nuclear weapons deployed by the United States and Russia. START II, which was recently ratified by the Russian Duma, will (if implemented) reduce the number deployed strategic nuclear weapons on each side to 3500, compared to a level of over 11,000 at the end of the Cold War in 1991. The tentative limit established by Presidents Clinton and Yeltsin for START III would reduce the strategic force level to 2000-2500. However, the Russians (along with a number of arms control advocates) now argue that the level should be reduced even further--to 1500 warheads or less. The conventional view is that ''deep cuts'' in nuclear weapons are necessary to discourage nuclear proliferation. Thus, as part of the bargain to get the non-nuclear states to agree to the renewal of the Nuclear Non-Proliferation Treaty, the United States pledged to work towards greater reductions in strategic forces. Without movement in the direction of deep cuts, it is thought by many analysts that some countries may decide to build their own nuclear weapons. Indeed, this was part of the rationale India used to justify its own nuclear weapons program. However, there is also some concern that deep cuts (to 1500 or lower) in the U.S. strategic nuclear arsenal could have the opposite effect. The fear is that such cuts might undermine extended deterrence and cause a crisis in confidence among U.S. allies to such an extent that they could seek nuclear weapons of their own to protect themselves.« less

Ethical dilemmas of nuclear deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russett, B.M.

An analysis of the May 1983 Pastoral Letter on War and Peace of the US Catholic Bishops examines their ethical arguments, which were critical of accepted policy while failing to change the underlying principles of acceptable deterrence and a just war. The author concludes that there is no easy solution to the problem of nuclear deterrence because there is no way to bridge the extremes of war-winning counterforce and possession without use. The Bishops' central problem was deterrence of attack on US allies or neutrals, but he finds merit in their positions that deterrence need not rely on nuclear threatsmore » and that new ways of thinking are needed for the long run. 20 references. (DCK)« less

Deterrents to Accountability.

ERIC Educational Resources Information Center

Hencley, Stephen P.

This speech assesses potential deterrents to the implementation of accountability in education. The author divides these deterrents into (1) philosophical-ideological; humanist-behaviorist conflicts, individuality versus "techno-urban fascism," and accountability systems tied to the achievement of cognitive objectives at the lower end of Bloom's…

Blunting the Talons. The Impact of Peace Operations Deployments on USAF Fighter Crew Combat Skills

DTIC Science & Technology

1999-01-01

Bomb Accuracy 74 Figure 5.16 - Typical Medium Altitude LGB Delivery 75 Figure 6.1 - Graph of Air-to-air Missile Shot Groups Showing Number of Shots...Between F-16C LGB and LALD/HD Practice Deliveries October 1997 Through February 1998 77 XI SUMMARY This document presents an analysis of the impact...intensive training promoted acted as a deterrent that reduced the chances war would occur - enhancing global stability. Thus, for the first 40

Strategic forum. Number 70. Regional deterrence strategies for new proliferation threats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahan, J.H.

1996-04-01

The deterrence of armed aggression against the United States, its vital national interests, or its allies has moved beyond the requirements of conventional force deterrence. The proliferation of nuclear, biological, and chemical (NBC) weapons requires a new strategy to ensure effective deterrence against their use by regional states that could not win in a conventional conflict with the United States. Because proliferation has expanded to a number of regional actors, a single strategy is unlikely to be sufficient in deterring states with varied motivations, and social, economic, religious, cultural, and political backgrounds. The Unified Commands-principally the Pacific, Central and Europeanmore » Commands- provide a ready-made framework in which general U.S. deterrence strategies can be tailored to each proliferant state While the Unified Commands would shape the individual deterrence strategies, the national command authority (NCA) would retain control of key decisions. Guidelines for NBC regional deterrence should include developing credible counterproliferation postures, profiling potential adversaries, tailoring our military capabilities to specific threats, integrating NBC preparedness into exercises and warplans, and actively pursuing coalitions designed to deter regional proliferators from threatening to use or using NBC weapons.« less

Systemic risk and hierarchical transitions of financial networks

NASA Astrophysics Data System (ADS)

Nobi, Ashadun; Lee, Jae Woo

2017-06-01

In this paper, the change in topological hierarchy, which is measured by the minimum spanning tree constructed from the cross-correlations between the stock indices from the S & P 500 for 1998-2012 in a one year moving time window, was used to analyze a financial crisis. The hierarchy increased in all minor crises in the observation time window except for the sharp crisis of 2007-2008 when the global financial crisis occurred. The sudden increase in hierarchy just before the global financial crisis can be used for the early detection of an upcoming crisis. Clearly, the higher the hierarchy, the higher the threats to financial stability. The scaling relations were developed to observe the changes in hierarchy with the network topology. These scaling relations can also identify and quantify the financial crisis periods, and appear to contain the predictive power of an upcoming crisis.

Systemic risk and hierarchical transitions of financial networks.

PubMed

Nobi, Ashadun; Lee, Jae Woo

2017-06-01

In this paper, the change in topological hierarchy, which is measured by the minimum spanning tree constructed from the cross-correlations between the stock indices from the S & P 500 for 1998-2012 in a one year moving time window, was used to analyze a financial crisis. The hierarchy increased in all minor crises in the observation time window except for the sharp crisis of 2007-2008 when the global financial crisis occurred. The sudden increase in hierarchy just before the global financial crisis can be used for the early detection of an upcoming crisis. Clearly, the higher the hierarchy, the higher the threats to financial stability. The scaling relations were developed to observe the changes in hierarchy with the network topology. These scaling relations can also identify and quantify the financial crisis periods, and appear to contain the predictive power of an upcoming crisis.

Deterrence by Denial: The Efficacy of U.S. Missile Defense in the Persian Gulf as a Deterrent Against the Iranian Regional Missile Threat

DTIC Science & Technology

2011-06-10

me throughout the entire process. Your professionalism and guidance were critical in making this a worthwhile study. Special thanks to my wife Jamie ...intelligence review by Michael Knights entitled ―Deterrence by punishment could offer last resort options for Iran‖ in April 2006. In this report, Knights ...RL32048, Iran: U.S. Concerns and Policy Responses. Washington, DC: Congressional Research Service, 20 August 2010. Knights , Michael. ―Deterrence by

76 FR 4555 - Authority To Require Supervision and Regulation of Certain Nonbank Financial Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... the stability of the United States financial system.'' In the recent financial crisis, financial... designations? How should the term ``managed assets'' be defined? Should the type of asset management activity... assets be considered? d. During the financial crisis, some firms provided financial support to investment...

Hypertensive crisis secondary to pheochromocytoma.

PubMed

Greenleaf, Christopher E; Griffin, Laura A; Shake, Jay G; Orr, Wayne S

2017-07-01

Pheochromocytoma is an uncommon tumor of the adrenal glands that can present with headaches, sweating, palpitations, and paroxysmal hypertension. Pheochromocytoma crisis can lead to cardiomyopathy, pulmonary edema, and even total circulatory collapse. We describe a patient with hypoxic respiratory failure requiring extracorporeal membrane oxygenation to stabilize until the pheochromocytoma was discovered and treated.

Sources of Deterrence: The Perceived Costs of Assault Versus Arrest.

ERIC Educational Resources Information Center

Hawkins, Richard; Williams, Kirk R.

Recent panel studies of deterrence have reported little evidence that perceptions of legal sanctions promote deterrence. Yet those studies have consistently found that extralegal sanctions "inhibit" criminal involvement. Conclusions drawn from this line of research remain speculative, however, because they are guided by an unnecessarily…

Crisis Stability and Long-Range Strike: A Comparative Analysis of Fighters, Bombers, and Missiles

DTIC Science & Technology

2013-01-01

1947–1949 Crisis pakistan: Seize Kashmir hawker tempests , but not brandished or employed no India: Deny pakistan control of Kashmir hawker... tempests , but not brandished or employed no war Berlin 1948–1949 Crisis uSSR: Force western powers out of west Berlin Bombers and strike aircraft...resolution to border dispute B-24, B-57, hF-24, tempest , Mystère IV, Ouragan aircraft, but none brandished or employed no war Table C.1

The nuclear debate: Deterrence and the lapse of faith

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tucker, R.W.

1985-01-01

This essay examines the growth of skepticism about the present system of nuclear deterrence. Tucker resists predicting the ultimate outcome, but he views the nuclear debate of this decade as an important ''lapse of faith'' in deterrence and he doubts there will ever be a full restoration of confidence.

Defining Deterrence in Cyberspace Working Toward a Framework to Integrate Cyber Deterrence

DTIC Science & Technology

2011-04-01

The goal of deterrence is not to deter the use of a particular weapon. Rather, a nation deters undesirable behavior. Cyber warfare can produce three...associated limitations will not produce a strategically decisive result. Cyber warfare must be used in conjunction with other instruments of power to

Deterrent Concentration Measurement with FTIR and Subsequent Ballistic Performance in Medium Caliber Propellant

NASA Technical Reports Server (NTRS)

Furrow, Keith W.; Ritchie, Steve J.; Morris, Amy

2000-01-01

To meet ballistic requirements, medium and small caliber propellants use deterrent coatings to obtain burn rate progressivity. The required amount and distribution of deterrent varies between gun systems, propellant types, and often between lots. Micro Fourier Transform Infrared (FTIR) spectroscopy was used to measure deterrent gradients in RP36 propellants coated with methyl centralite (MC) at different deterrent levels and different processing conditions. The aromatic C-C bonds at 1496 cm(exp -1) wavenumber were used to monitor the deterrent profiles through the grain. Deterrent gradients measured with FTIR spectroscopy were then used to estimate burn rate gradients in the deterred grains. Burn rates were calculated from literature models and from closed bomb data of RP36 containing uniform deterrent concentration. Finally, the burn rate gradients were input into an IBHFG2 model of a 200 cc-closed bomb. The early flame spreading portion of the closed bomb ballistic cycle (0 to 0.2 P/Pmax) was roughly modeled by dividing the charge up into five propellant decks and igniting them at different times in the ballistic cycle. Pressure traces and vivacity curves from closed bomb shots were compared to predictions. In addition to the burn rate gradient, the closed bomb pressure trace was heavily dependent on ignition and flame spread. These two phenomena were not readily distinguishable from one another in deterred grains. The same RP-36 propellant was shot in a 25 mm M793TP round which was again modeled with IBHVG2. Peak pressure and muzzle velocity were accurately modeled when erosive burning effects were empirically factored into the model.

Global 93: Deterrence Theory for the Coming Decade

DTIC Science & Technology

1993-06-30

likely to create in the near future. They will not create contingencies in which U.S. power is a relevant deterrent." Raj Krishna , "India and the Bomb...Obsolescence of MaiorWar (New York: Basic Books, 1989) Naroll, Raoul, Vern L. Bullough, and Frada Naroll, Military Deterrence in History (Albany: State

An evaluation of mosquito repellents and essential plant oils as deterrents of Asian citrus psyllid

USDA-ARS?s Scientific Manuscript database

This study objectives were to evaluate mosquito repellents against Asian citrus psyllid (ACP) and to expand our knowledge of the potential of essential plant oils as deterrents of adult infestations. Twenty-two candidate deterrents were tested as 20% solutions in methanol using a laboratory assay. G...

Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations

PubMed Central

Turk, Dennis C.; O’Connor, Alec B.; Dworkin, Robert H.; Chaudhry, Amina; Katz, Nathaniel P.; Adams, Edgar H.; Brownstein, John S.; Comer, Sandra D.; Dart, Richard; Dasgupta, Nabarun; Denisco, Richard A.; Klein, Michael; Leiderman, Deborah B.; Lubran, Robert; Rappaport, Bob A.; Zacny, James P.; Ahdieh, Harry; Burke, Laurie B.; Cowan, Penney; Jacobs, Petra; Malamut, Richard; Markman, John; Michna, Edward; Palmer, Pamela; Peirce-Sandner, Sarah; Potter, Jennifer S.; Raja, Srinivasa N.; Rauschkolb, Christine; Roland, Carl L.; Webster, Lynn R.; Weiss, Roger D.; Wolf, Kerry

2013-01-01

Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Due to the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs in order to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability; (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation; (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse; and (4) post-marketing epidemiological studies. PMID:22770841

Deficiency of gustatory sensitivity to some deterrent compounds in "polyphagous" mutant strains of the silkworm, Bombyx mori.

PubMed

Asaoka, K

2000-11-01

Sawa-J, CSJ02 and N601 x C601 are selected mutant strains of Bombyx mori, which grow on various artificial diets or temporarily ingest various plant leaves. To examine the mechanisms mediating diet breadth of caterpillars, gustatory spike responses of the silkworms, called 'polyphagous" strains, were compared with normal strains, N137 x C146 and C02. There were notable differences in their feeding habits and in their sensitivity to salicin in deterrent cells in the maxillary medial styloconic sensilla and the epipharyngeal sensilla. By contrast, the deterrent cells of all strains responded similarly to strychnine nitrate in a dose-dependent manner. In additional comparisons of Sawa-J and N137 x C146, Sawa-J maxillary deterrent cells were significantly less sensitive to phloridzin, amygdalin and arbutin, but responded to some alkaloids and 20-hydroxyecdysone with similar or even higher firing rate. These results suggest that the deficiency of the sensitivity to some deterrent compounds on the deterrent cell of the polyphagous strains may be caused by mutant genes and affects the diet breadth of caterpillars.

The value of vengeance and the demand for deterrence.

PubMed

Crockett, Molly J; Özdemir, Yagiz; Fehr, Ernst

2014-12-01

Humans will incur costs to punish others who violate social norms. Theories of justice highlight 2 motives for punishment: a forward-looking deterrence of future norm violations and a backward-looking retributive desire to harm. Previous studies of costly punishment have not isolated how much people are willing to pay for retribution alone, because typically punishment both inflicts damage (satisfying the retributive motive) and communicates a norm violation (satisfying the deterrence motive). Here, we isolated retributive motives by examining how much people will invest in punishment when the punished individual will never learn about the punishment. Such "hidden" punishment cannot deter future norm violations but was nevertheless frequently used by both 2nd-party victims and 3rd-party observers of norm violations, indicating that retributive motives drive punishment decisions independently from deterrence goals. While self-reports of deterrence motives correlated with deterrence-related punishment behavior, self-reports of retributive motives did not correlate with retributive punishment behavior. Our findings reveal a preference for pure retribution that can lead to punishment without any social benefits. PsycINFO Database Record (c) 2014 APA, all rights reserved.

The Value of Vengeance and the Demand for Deterrence

PubMed Central

2014-01-01

Humans will incur costs to punish others who violate social norms. Theories of justice highlight 2 motives for punishment: a forward-looking deterrence of future norm violations and a backward-looking retributive desire to harm. Previous studies of costly punishment have not isolated how much people are willing to pay for retribution alone, because typically punishment both inflicts damage (satisfying the retributive motive) and communicates a norm violation (satisfying the deterrence motive). Here, we isolated retributive motives by examining how much people will invest in punishment when the punished individual will never learn about the punishment. Such “hidden” punishment cannot deter future norm violations but was nevertheless frequently used by both 2nd-party victims and 3rd-party observers of norm violations, indicating that retributive motives drive punishment decisions independently from deterrence goals. While self-reports of deterrence motives correlated with deterrence-related punishment behavior, self-reports of retributive motives did not correlate with retributive punishment behavior. Our findings reveal a preference for pure retribution that can lead to punishment without any social benefits. PMID:25285429

Drug dealers, retaliation, and deterrence.

PubMed

Jacques, Scott; Wright, Richard; Allen, Andrea

2014-07-01

Illicit drug sellers have limited access to formal mediation and therefore are rational targets to predators. As such, dealers are especially reliant on retaliation to deter victimization. Prior scholarship on dealers, retaliation, and deterrence has focused largely on general deterrence, or the effect of punishing one person on others. Research is yet to shed much light on other types of deterrence that dealers engage in. This paper addresses that gap by drawing on qualitative data obtained in interviews with 25 unincarcerated drug sellers from disadvantaged neighborhoods in St. Louis, Missouri. We find that dealers' use of retaliation is linked to four kinds of deterrence-general, specific, situational, and permeating-and that these are combined into three forms: namely, specific-situational; specific-permeating; and comprehensive (i.e., all four kinds simultaneously). Implications for research, theory, and "criminal justice" are discussed. Specifically, we call for future scholarship to examine how each type of deterrence affects the others, and suggest that both predation against and retaliation by drug dealers might be reduced by granting them greater access to formal means of dispute resolution. Copyright © 2014 Elsevier B.V. All rights reserved.

Effects of acoustic deterrents on foraging bats

USGS Publications Warehouse

Johnson, Joshua B.; Ford, W. Mark; Rodrigue, Jane L.; Edwards, John W.

2012-01-01

Significant bat mortality events associated with wind energy expansion, particularly in the Appalachians, have highlighted the need for development of possible mitigation practices to reduce or prevent strike mortality. Other than increasing turbine cut-in speed, acoustic deterrents probably hold the greatest promise for reducing bat mortality. However, acoustic deterrent effectiveness and practicality has not been experimentally examined and is limited to site-specific case studies. Accordingly, we used a crossover experimental design with prior control period to show that bat activity was reduced 17.1 percent by the deployment of ultrasonic deterrents placed around gauged watershed weir ponds on the Fernow Experimental Forest in West Virginia. We caution that while our results should not be extrapolated to the scope of a typical wind energy production facility, the results warrant further research on the use of acoustic deterrents to reduce bat fatalities.

Models for financial crisis detection in Indonesia based on bank deposits, real exchange rate and terms of trade indicators

NASA Astrophysics Data System (ADS)

Sugiyanto; Zukhronah, Etik; Nur Aini, Anis

2017-12-01

Several times Indonesia has experienced to face a financial crisis, but the crisis occurred in 1997 had a tremendous impact on the economy and national stability. The impact of the crisis fall the exchange rate of rupiah against the dollar so it is needed the financial crisis detection system. Some data of bank deposits, real exchange rate and terms of trade indicators are used in this paper. Data taken from January 1990 until December 2016 are used to form the models with three state. Combination of volatility and Markov switching models are used to model the data. The result suggests that the appropriate model for bank deposit and terms of trade is SWARCH (3,1), and for real exchange rates is SWARCH (3,2).

Mechanisms of Feeding Deterrence by Ziziphins.

DTIC Science & Technology

1985-05-30

number) e mechanism of feeding deterrence by ziziphins for sout rn armyworms ( Spodoptera eridania ; Lepidoptera:Noctuidae) was investigated using bo long... Spodoptera eridania , to investigate the mechanisms of feeding deterrence by ziziphins extracted from the leaves of • .Ziziphus jujuba. Evaluation...Videotape Analysis of Feeding Suppression in the Southern Armyworm ( Spodoptera eridania ; Lepidoptera: Noctuidae) Produced by Extracts of the

Cracks in the New Jar: The Limits of Tailored Deterrence

DTIC Science & Technology

2011-03-17

motivated biases, which result from subconscious psychological pressure that distorts perception. Motivated biases differ from cognitive biases...deterrence theory, including the uncertainty and cognitive biases inherent to both intelligence assessments and international relations. While...neglects some of the most important elements of contemporary deterrence theory, including the uncertainty and cognitive biases inherent to both

The Relative Effectiveness of Various Incentives and Deterrents as Judged by Pupils and Teachers.

ERIC Educational Resources Information Center

Burns, Robert B.

1978-01-01

Compares opinions of British teachers and students toward educational incentives and deterrents. Little change has occurred in the responses of teachers and students over the 24 years. Differences of opinion are evident between pupils and teachers, especially with regard to corporal punishment as a deterrent and adult approval as an incentive.…

Feeding and oviposition deterrent activities of flower buds of globemallow,Sphaeralcea emoryi torrey, against boll weevil,Anthonomus grandis Boheman (Coleoptera: Curculionidae).

PubMed

Honda, H; Bowers, W S

1996-01-01

The globemallow,Sphaeralcea emoryi Torrey, a plant native to Arizona was evaluated as a source of feeding or oviposition deterrents to the boll weevil,Anthonomus grandis Boheman. Feeding and oviposition responses of reproductive weevils to the flower buds and artificial diets spiked with dry powder or extracts of the globemallow buds were determined. Boll weevils were deterred from feeding and ovipositing in the flower buds unless the calyxes were removed. Male and virgin female weevils were discouraged from feeding as much as gravid weevils. Secondary chemicals in the flower buds served primarily as feeding deterrents but also prevented oviposition. The concentration of these chemicals was highest in the calyxes of the buds, and potent deterrent activity could be extracted from the calyxes with methanol. Boll weevils were able to perceive the deterrents by contact chemosensory organs on the antennae, maxillary palps and labial palps.

Increasing Uncertainty: The Dangers of Relying on Conventional Forces for Nuclear Deterrence

DTIC Science & Technology

2016-03-14

designed by the United States to meet its nuclear deterrence needs are not constrained by the “nuclear taboo ” and, in fact, are more usable.38 The...Nuclear deterrence may be much more fragile than any of us realize. It is imperative that we do not take the “nuclear taboo ” for granted by assuming

A Cross-Cultural Study of Punishment Beliefs and Decisions.

PubMed

Zhang, Yanyan; Chen, Chuansheng; Greenberger, Ellen; Knowles, Eric D

2017-02-01

The current research examined cultural similarities and differences in punishment beliefs and decisions. Participants were European Americans ( N = 50), Chinese Americans ( N = 57), and Chinese in Mainland China ( N = 50). The Functions of Punishment Questionnaire was used to measure participants' beliefs about the retributive or deterrent functions of punishment and a scenario method was used to measure the extent to which punishment decisions were driven by individuals' concerns for retribution or deterrence. The results indicated that, contrary to the hypothesis that the retributive function would be emphasized by individualistic groups and the deterrent function by collectivistic groups, Mainland Chinese participants had a stronger belief in retribution and a weaker belief in deterrence than did European and Chinese Americans. The results also indicated that retribution played a bigger role in punishment decisions for Chinese than for the other two groups, but the importance of the deterrence function in punishment decisions did not differ across the three groups. Finally, the correlation between interdependence orientation and the belief in retribution was positive for Chinese but negative for European Americans. Taken together, the findings provided little evidence that collectivists are more deterrence-oriented and individualists more retribution-oriented.

Cult of deterrence: A moral and strategic critique of the anti-ballistic missile treaty. Master`s thesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pringle, C.S.

1997-12-30

Ballistic missile defense is the morally and strategically superior alternative to the current system of deterrence, provided that it is responsibly implemented. Analysis of the Just War Criteria and the utilitarian justifications of deterrence present a moral obligation to pursue the alternative strategy of missile defense as a means of defending the United States. However, the Anti-Ballistic Missile (ABM) Treaty does not allow earnest pursuit of this alternative, despite recent efforts to exploit its loopholes and broaden its meaning beyond any reasonable limit. Moreover, deterrence can no longer provide the guarantee of security that it did during the Cold War.more » Offense-Defense Theory shows that revisionist states are not subject to the same calculations of effective deterrence that the Soviet Union was during that period. This strategic analysis underlies the moral evaluations and further supports missile defense. The cult of deterrence is presented as an explanation for the failure to adapt national security policy to the new international structure, as European powers failed to perceive the offense-defense balance prior to World War I. The ABM regime threatens to reproduce those same mistakes with even greater consequences.« less

Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations.

PubMed

Turk, Dennis C; O'Connor, Alec B; Dworkin, Robert H; Chaudhry, Amina; Katz, Nathaniel P; Adams, Edgar H; Brownstein, John S; Comer, Sandra D; Dart, Richard; Dasgupta, Nabarun; Denisco, Richard A; Klein, Michael; Leiderman, Deborah B; Lubran, Robert; Rappaport, Bob A; Zacny, James P; Ahdieh, Harry; Burke, Laurie B; Cowan, Penney; Jacobs, Petra; Malamut, Richard; Markman, John; Michna, Edward; Palmer, Pamela; Peirce-Sandner, Sarah; Potter, Jennifer S; Raja, Srinivasa N; Rauschkolb, Christine; Roland, Carl L; Webster, Lynn R; Weiss, Roger D; Wolf, Kerry

2012-10-01

Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Because of the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability, (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation, (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse, and (4) postmarketing epidemiological studies. Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

The effects of initial participation motivations on learning engagement in transition training for future general practitioners in rural China: perceived deterrents as mediator

PubMed Central

Cui, Guan-yu; Yao, Mei-lin; Zhang, Xia; Guo, Yan-kui; Li, Hui-min; Yao, Xiu-ping

2016-01-01

Background For the shortage of high-quality general practitioners (GPs) in China's rural areas, Chinese government has taken steps to encourage rural specialists to participate in transition training for future GPs. Specialists’ initial participation motivations and their perceived deterrents during training may play important roles for their learning engagement in the transition training. This study aimed at revealing the relationships among the variables of initial participation motivations, perceived deterrents in training, and learning engagement. Methods A questionnaire survey was used in this study. A total of 156 rural specialists who participated in transition training for future GPs filled out the questionnaire, which consisted of the measurements of initial participation motivations, perceived deterrents, and learning engagement in training. The data about specialists’ demographic variables were collected at the same time. Results The variance of initial escape/stimulations motivation significantly predicted the variance of learning engagement through the full mediating role of perceived deterrents in training. In addition, initial educational preparation motivations predicted the variance of learning engagement directly. Conclusions Specialists’ initial participation motivations and perceived deterrents in training played important roles for learning engagement in the transition training. PMID:27340086

Clinical and Insurance Perspectives on Intermediate Levels of Care in Psychiatry.

PubMed

Plakun, Eric M

2018-03-01

This column compares a clinical perspective on the continuum of care for mental health and substance use disorders with a different perspective derived from publicly available insurance company documents and experience dealing with managed care utilization reviewers. The latter perspective tends to determine the need for access to levels of care based on the need for crisis stabilization, whereas the generally accepted clinical standard is more nuanced than the need for crisis stabilization alone. The column proposes that this discrepancy in perspectives makes a substantial contribution to disagreements between treating clinicians, such as therapists, and insurance utilization reviewers concerning the medical necessity of various requested levels of care.

Is crisis stability still achievable?

NASA Astrophysics Data System (ADS)

Pollack, Joshua

During the Cold War, the idea of crisis stability concerned whether the United States and the Soviet Union would be faced with powerful incentives to strike each other first with their nuclear weapons during periods of tension. This idea influenced the design of nuclear forces and guided aspects of nuclear arms control. The United States and Russia continue to operate large, alert nuclear forces, but at least three new factors have emerged that add significantly greater complexity to this picture. The first new factor consists of the development and deployment of new strategic military technologies that are entangled with nuclear weapons. These include strategic ballistic missile defenses, counter-space weapons, and strategic conventional weapons. The second new factor consists of new dyads of interacting strategic forces beyond US-Russia. These include US-China, US-North Korea, India-Pakistan, and India-China. The third new factor consists of the emergence of three-actor crisis stability dynamics, where the third actor is not necessarily nuclear-armed. This paper illustrates the concept with the US-North Korea-South Korea triangle. It briefly discusses the implications of these developments and reflects on the broad policy options that may be available.

From Crisis to Stability: A Case Study of Presidential Leadership at a Christian College

ERIC Educational Resources Information Center

Gill, Jeffrey

2012-01-01

Despite healthy growth in past decades, in a time of national and global economic instability small, private Christian colleges now find themselves in a precarious position. Leading effectively in such colleges and universities in a time of external and/or internal crisis is a great challenge. This research is about a small, Christian college with…

Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process.

PubMed

Ducray, C; Pommier, J P; Martins, L; Boussin, F D; Sabatier, L

1999-07-22

Loss of telomeric repeats during cell proliferation could play a role in senescence. It has been generally assumed that activation of telomerase prevents further telomere shortening and is essential for cell immortalization. In this study, we performed a detailed cytogenetic and molecular characterization of four SV40 transformed human fibroblastic cell lines by regularly monitoring the size distribution of terminal restriction fragments, telomerase activity and the associated chromosomal instability throughout immortalization. The mean TRF lengths progressively decreased in pre-crisis cells during the lifespan of the cultures. At crisis, telomeres reached a critical size, different among the cell lines, contributing to the peak of dicentric chromosomes, which resulted mostly from telomeric associations. We observed a direct correlation between short telomere length at crisis and chromosomal instability. In two immortal cell lines, although telomerase was detected, mean telomere length still continued to decrease whereas the number of dicentric chromosomes associated was stabilized. Thus telomerase could protect specifically telomeres which have reached a critical size against end-to-end dicentrics, while long telomeres continue to decrease, although at a slower rate as before crisis. This suggests a balance between elongation by telomerase and telomere shortening, towards a stabilized 'optimal' length.

Structural Activity of Bovidic Acid and Related Compounds as Feeding Deterrents against Aedes aegypti

DTIC Science & Technology

2007-01-01

fatty acid analogues were evaluated against Aedes aegypti (L.) mosquitoes and results indicate that this may generate class of topical repellents for use...duced risk to humans, pets and environment, natu- Structural Activity of Bovidic Acid and Related Compounds as Feeding Deterrents against Aedes aegypti K...against insects that transmit pathogens to humans. KEY WORDS : Bovidic acid , feeding deterrents , Aedes aegypti , hydroxy furanoid

Deterrence and WMD Terrorism: Calibrating Its Potential Contributions to Risk Reduction

DTIC Science & Technology

2007-06-01

ideology and aspiration (so-called franchisees ) • operational enablers (financiers etc.) • moral legitimizers • state sponsors • passive state...of al Qaeda • groups affiliated by ideology and aspiration (so-called franchisees ) • operational enablers (financiers etc.) • moral legitimizers...of deterrence.14 One is “deterrence by the threat of punishment,” which compels the adversary to try to calculate whether the potential benefits of

A heterogeneous artificial stock market model can benefit people against another financial crisis

PubMed Central

2018-01-01

This paper presents results of an artificial stock market and tries to make it more consistent with the statistical features of real stock data. Based on the SFI-ASM, a novel model is proposed to make agents more close to the real world. Agents are divided into four kinds in terms of different learning speeds, strategy-sizes, utility functions, and level of intelligence; and a crucial parameter has been found to ensure system stability. So, some parameters are appended to make the model which contains zero-intelligent and less-intelligent agents run steadily. Moreover, considering real stock markets change violently due to the financial crisis; the real stock markets are divided into two segments, before the financial crisis and after it. The optimal modified model before the financial crisis fails to replicate the statistical features of the real market after the financial crisis. Then, the optimal model after the financial crisis is shown. The experiments indicate that the optimal model after the financial crisis is able to replicate several of real market phenomena, including the first-order autocorrelation, kurtosis, standard deviation of yield series and first-order autocorrelation of yield square. We point out that there is a structural change in stock markets after the financial crisis, which can benefit people forecast the financial crisis. PMID:29912893

A heterogeneous artificial stock market model can benefit people against another financial crisis.

PubMed

Yang, Haijun; Chen, Shuheng

2018-01-01

This paper presents results of an artificial stock market and tries to make it more consistent with the statistical features of real stock data. Based on the SFI-ASM, a novel model is proposed to make agents more close to the real world. Agents are divided into four kinds in terms of different learning speeds, strategy-sizes, utility functions, and level of intelligence; and a crucial parameter has been found to ensure system stability. So, some parameters are appended to make the model which contains zero-intelligent and less-intelligent agents run steadily. Moreover, considering real stock markets change violently due to the financial crisis; the real stock markets are divided into two segments, before the financial crisis and after it. The optimal modified model before the financial crisis fails to replicate the statistical features of the real market after the financial crisis. Then, the optimal model after the financial crisis is shown. The experiments indicate that the optimal model after the financial crisis is able to replicate several of real market phenomena, including the first-order autocorrelation, kurtosis, standard deviation of yield series and first-order autocorrelation of yield square. We point out that there is a structural change in stock markets after the financial crisis, which can benefit people forecast the financial crisis.

How Close is too Close? The Effect of a Non-Lethal Electric Shark Deterrent on White Shark Behaviour.

PubMed

Kempster, Ryan M; Egeberg, Channing A; Hart, Nathan S; Ryan, Laura; Chapuis, Lucille; Kerr, Caroline C; Schmidt, Carl; Huveneers, Charlie; Gennari, Enrico; Yopak, Kara E; Meeuwig, Jessica J; Collin, Shaun P

2016-01-01

Sharks play a vital role in the health of marine ecosystems, but the potential threat that sharks pose to humans is a reminder of our vulnerability when entering the ocean. Personal shark deterrents are being marketed as the solution to mitigate the threat that sharks pose. However, the effectiveness claims of many personal deterrents are based on our knowledge of shark sensory biology rather than robust testing of the devices themselves, as most have not been subjected to independent scientific studies. Therefore, there is a clear need for thorough testing of commercially available shark deterrents to provide the public with recommendations of their effectiveness. Using a modified stereo-camera system, we quantified behavioural interactions between white sharks (Carcharodon carcharias) and a baited target in the presence of a commercially available, personal electric shark deterrent (Shark Shield Freedom7™). The stereo-camera system enabled an accurate assessment of the behavioural responses of C. carcharias when encountering a non-lethal electric field many times stronger than what they would naturally experience. Upon their first observed encounter, all C. carcharias were repelled at a mean (± std. error) proximity of 131 (± 10.3) cm, which corresponded to a mean voltage gradient of 9.7 (± 0.9) V/m. With each subsequent encounter, their proximity decreased by an average of 11.6 cm, which corresponded to an increase in tolerance to the electric field by an average of 2.6 (± 0.5) V/m per encounter. Despite the increase in tolerance, sharks continued to be deterred from interacting for the duration of each trial when in the presence of an active Shark Shield™. Furthermore, the findings provide no support to the theory that electric deterrents attract sharks. The results of this study provide quantitative evidence of the effectiveness of a non-lethal electric shark deterrent, its influence on the behaviour of C. carcharias, and an accurate method for testing other shark deterrent technologies.

How Close is too Close? The Effect of a Non-Lethal Electric Shark Deterrent on White Shark Behaviour

PubMed Central

Hart, Nathan S.; Ryan, Laura; Chapuis, Lucille; Kerr, Caroline C.; Schmidt, Carl; Huveneers, Charlie; Gennari, Enrico; Yopak, Kara E.; Meeuwig, Jessica J.; Collin, Shaun P.

2016-01-01

Sharks play a vital role in the health of marine ecosystems, but the potential threat that sharks pose to humans is a reminder of our vulnerability when entering the ocean. Personal shark deterrents are being marketed as the solution to mitigate the threat that sharks pose. However, the effectiveness claims of many personal deterrents are based on our knowledge of shark sensory biology rather than robust testing of the devices themselves, as most have not been subjected to independent scientific studies. Therefore, there is a clear need for thorough testing of commercially available shark deterrents to provide the public with recommendations of their effectiveness. Using a modified stereo-camera system, we quantified behavioural interactions between white sharks (Carcharodon carcharias) and a baited target in the presence of a commercially available, personal electric shark deterrent (Shark Shield Freedom7™). The stereo-camera system enabled an accurate assessment of the behavioural responses of C. carcharias when encountering a non-lethal electric field many times stronger than what they would naturally experience. Upon their first observed encounter, all C. carcharias were repelled at a mean (± std. error) proximity of 131 (± 10.3) cm, which corresponded to a mean voltage gradient of 9.7 (± 0.9) V/m. With each subsequent encounter, their proximity decreased by an average of 11.6 cm, which corresponded to an increase in tolerance to the electric field by an average of 2.6 (± 0.5) V/m per encounter. Despite the increase in tolerance, sharks continued to be deterred from interacting for the duration of each trial when in the presence of an active Shark Shield™. Furthermore, the findings provide no support to the theory that electric deterrents attract sharks. The results of this study provide quantitative evidence of the effectiveness of a non-lethal electric shark deterrent, its influence on the behaviour of C. carcharias, and an accurate method for testing other shark deterrent technologies. PMID:27368059

Stability, Crisis, and Other Reasons for Optimism: University Foreign Language Education in the United States

ERIC Educational Resources Information Center

Levine, Glenn S.

2011-01-01

This article presents a brief overview of the state of university language education in the United States. Despite the impact of the world economic crisis on university language education in the United States, the profession has not yet been impacted to the extent many believe it has. Current scholarly debates allow for both a sober assessment of…

Gaming Space: A Game-Theoretic Methodology for Assessing the Deterrent Value of Space Control Options

DTIC Science & Technology

2018-06-07

Gaming Space A Game-Theoretic Methodology for Assessing the Deterrent Value of Space Control Options C O R...in space. Adversaries have already employed non -kinetic OSC capabilities, such as Global Positioning System jammers, in recent conflicts, and they...as part of the project “Assessing the Deterrent Value of Defensive Space Control Options.” The purpose of the project was to develop a methodology

On Nuclear Deterrence and Assurance

DTIC Science & Technology

2009-01-01

Strategic  Studies  Quarterly ♦  Spring  2009 [ 43 ] On Nuclear Deterrence  and Assurance Keith B. Payne Weakness is provocative. —Donald Rumsfeld...Strategic  Studies  Quarterly ♦  Spring  2009 Keith B. Payne [ 44 ] No Deterrence Value for Nuclear Weapons...Payne.indd 44 2/2/09 2:31:00 PM On Nuclear Deterrence and Assurance Strategic  Studies  Quarterly ♦  Spring  2009 [ 45 ] of nuclear weapons were to be

Trends & Controversies: Sociocultural Predictive Analytics and Terrorism Deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sanfilippo, Antonio P.; McGrath, Liam R.

2011-08-12

The use of predictive analytics to model terrorist rhetoric is highly instrumental in developing a strategy to deter terrorism. Traditional (e.g. Cold-War) deterrence methods are ineffective with terrorist groups such as al Qaida. Terrorists typically regard the prospect of death or loss of property as acceptable consequences of their struggle. Deterrence by threat of punishment is therefore fruitless. On the other hand, isolating terrorists from the community that may sympathize with their cause can have a decisive deterring outcome. Without the moral backing of a supportive audience, terrorism cannot be successfully framed as a justifiable political strategy and recruiting ismore » curtailed. Ultimately, terrorism deterrence is more effectively enforced by exerting influence to neutralize the communicative reach of terrorists.« less

From Negative to Positive Stability: How the Syrian Refugee Crisis Can Improve Jordan’s Outlook

DTIC Science & Technology

2015-01-01

Syrian Refugees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Forecast: The Impact of Syrian Refugees on Jordan’s Economic Stability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22...Syrians find economic stability , they will be less vulnerable to the loss of aid, and therefore less likely to present a drain on Jordanian society...with Syrian refugees, and presents a forecast of Syrian refugee impacts on Jordan’s economy and such economic stability factors as unem- ployment and

The stability of financial market networks

NASA Astrophysics Data System (ADS)

Yan, Xin-Guo; Xie, Chi; Wang, Gang-Jin

2014-08-01

We investigate the stability of a financial market network by measuring its topological robustness, namely the ability of the network to resist structural or topological changes. The closing prices of 710 stocks in the Shanghai Stock Exchange (SSE) from 2005 to 2011 are chosen as the empirical data. We divide the period into three sub-periods: before, during, and after the US sub-prime crisis. By monitoring the size of the clusters which fall apart from the network after removing the nodes (i.e., the listed companies in the SSE), we find that: i) the SSE network is sensitive to the nodes' failure, which implies that the network is unstable. ii) the SSE network before the financial crisis has the strongest robustness against the intentional topological damage; iii) the hubs (i.e., highly connected nodes) connect with each other directly and play a vital important role in maintaining SSE network's stability.

Current Impact and Application of Abuse-Deterrent Opioid Formulations in Clinical Practice.

PubMed

Lee, Ya-Han; Brown, Daniel L; Chen, Hsiang-Yin

2017-11-01

Abuse-deterrent formulations (ADFs) represent one novel strategy for curbing the potential of opioid abuse. We aim to compare and contrast the characteristics and applications of current abuse-deterrent opioid products in clinical practice. Literature searches were conducted in databases (Pubmed Medline, International Pharmaceutical Abstracts, Google Scholar) and official reports. Relevant data were screened and organized into: 1) epidemiology of opioid abuse, 2) mitigation strategies for reducing opioid abuse, 3) development of ADFs, and 4) clinical experience with these formulations. Increasing trends of opioid abuse and misuse have been reported globally. There are 5 types of abuse-deterrent opioid products: physical chemical barrier, combined agonist/antagonist, sequestered aversive agent, prodrug, and novel delivery system. The advantages and disadvantages of the 5 options are discussed in this review. A total of 9 products with abuse-deterrent labels have been approved by the Food and Drug Administration (FDA). The rates of abuse, diversion, and overdose deaths of these new products are also discussed. A framework for collecting in-time data on the efficacy, benefit and risk ratio, and cost-effectiveness of these new products is suggested to facilitate their optimal use. The present review did not utilize systematic review standards or meta-analytic techniques, given the large heterogeneity of data and outcomes reviewed. ADFs provide an option for inhibiting the abuse or misuse of oral opioid products by hindering extraction of the active ingredient, preventing alternative routes of administration, or causing aversion. Their relatively high costs, uncertain insurance policies, and limited data on pharmacoeconomics warrant collaborative monitoring and assessment by government agencies, pharmaceutical manufacturers, and data analysis services to define their therapeutic role in the future. Opioid abuse, abuse-deterrent formulations, ADF, post-marketing, FDA guidance, cost impact, abuse liking, physician attitude, generic abuse-deterrent formulation, clinical application.

Dynamical generalized Hurst exponent as a tool to monitor unstable periods in financial time series

NASA Astrophysics Data System (ADS)

Morales, Raffaello; Di Matteo, T.; Gramatica, Ruggero; Aste, Tomaso

2012-06-01

We investigate the use of the Hurst exponent, dynamically computed over a weighted moving time-window, to evaluate the level of stability/instability of financial firms. Financial firms bailed-out as a consequence of the 2007-2008 credit crisis show a neat increase with time of the generalized Hurst exponent in the period preceding the unfolding of the crisis. Conversely, firms belonging to other market sectors, which suffered the least throughout the crisis, show opposite behaviors. We find that the multifractality of the bailed-out firms increase at the crisis suggesting that the multi fractal properties of the time series are changing. These findings suggest the possibility of using the scaling behavior as a tool to track the level of stability of a firm. In this paper, we introduce a method to compute the generalized Hurst exponent which assigns larger weights to more recent events with respect to older ones. In this way large fluctuations in the remote past are less likely to influence the recent past. We also investigate the scaling associated with the tails of the log-returns distributions and compare this scaling with the scaling associated with the Hurst exponent, observing that the processes underlying the price dynamics of these firms are truly multi-scaling.

Assessing the Deterrence Value of Carrier Presence Against Adversary Aggression in a Coalition Environment

DTIC Science & Technology

2017-09-01

seeks to quantify the deterrence value of a CSG using a game - theoretic framework. Consider a region with several nations, where two major players stand...develop a Markov game to model the interactions between the two players and these other nations over a period of time. The game starts in Notional...establishing diplomatic advantage are equally important in deterring aggression. 14. SUBJECT TERMS carrier strike group, CSG, deterrence, Markov game

A Study on the Failure of Conventional Deterrence: The Case Study of the Bombardment of Yeonpyeong in 2010

DTIC Science & Technology

2016-12-01

December 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE A STUDY ON THE FAILURE OF CONVENTIONAL DETERRENCE: THE CASE ...Approved for public release. Distribution is unlimited A STUDY ON THE FAILURE OF CONVENTIONAL DETERRENCE: THE CASE STUDY OF THE BOMBARDMENT OF...necessary to analyze these diverse elements comprehensively. E. RESEARCH DESIGN This thesis focuses on a single case study about the bombardment of

Strategic Studies Quarterly. Volume 6, Number 2. Summer 2012

DTIC Science & Technology

2012-06-01

Jr . Forging an Indian Partnership Capt Craig H. Neuman II, USAF Chasing Its Tail: Nuclear Deterrence in the Information Age? Stephen J. Cimbala Commentary Our Brick Moon William H. Gerstenmaier ...Su m m er 2012 SUMMER 2012 Vol. 6, No. 2 Commentary Our Brick Moon William H. Gerstenmaier Chasing Its Tail: Nuclear Deterrence in...Extended Deterrence: How Much Strategic Force Is Too Little? David J. Trachtenberg The Common Sense of Small Nuclear Arsenals James Wood Forsyth

Feeding deterrent compounds to the boll weevil,Anthonomus grandis Boheman in Rose-of-Sharon,Hibiscus syriacus L.

PubMed

Bird, T G; Hedin, P A; Burks, M L

1987-05-01

The Rose-of-Sharon,Hibiscus syriacus (L.), can be a significant alternate host plant for the boll weevil,Anthonomus gradis (Boh.). Boll weevils are known to be deterred from feeding and ovipositing in the buds unless the calyx is removed. This investigation was initiated to identify calyx allelochemicals that deter feeding with the eventual strategy of breeding for cotton lines high in these allelochemicals in the appropriate tissues. The feeding deterrency of calyx tissue from the buds of Rose-of-Sharon for the boll weevil was confirmed. The most active deterrent fraction was found to contain mostly fatty acids and their methyl esters. Saturated fatty acids and their methyl esters were generally found to be stimulatory, while the unsaturated species were found to be deterrent. Higher quantities of the fatty acids, particularly the unsaturated species, were found in Rose-of-Sharon calyx tissue than in the buds without calyx. This supports the hypothesis developed through the isolational work and testing of standards that the unsaturated fatty acids are significant deterrents of boll weevil feeding.

Isolation and Identification of Mosquito (Aedes aegypti) Biting-Deterrent Compounds from the Native American Ethnobotanical Remedy Plant Hierochloë odorata (Sweetgrass).

PubMed

Cantrell, Charles L; Jones, A Maxwell P; Ali, Abbas

2016-11-09

Hierochloë odorata (L.) P. Beauv. (Poaceae), commonly known as sweetgrass, has documented use as an insect repellent by the Flatheads of Montana and Blackfoot of Alberta. Both the Flatheads of Montana and Blackfoot of Alberta would use braided plant material in a sachet in clothing or burn them from one end as incense, air/clothing freshener, and insect repellent. This study evaluated the insect-repellent properties of this plant using an in vitro mosquito Aedes aegypti feeding bioassay-directed approach to identify the compound(s) responsible for the observed activities. Evaluation of crude extracts produced from H. odorata revealed that the hydrodistillate had the highest level of mosquito biting deterrence. Fractionation of this extract, followed by re-evaluation for mosquito biting deterrence, produced many active fractions, which were evaluated by spectroscopic techniques and determined to contain phytol, coumarin, and 2-methoxy-4-vinylphenol. Phytol and coumarin were both determined to be responsible for the Ae. aegypti biting deterrency. Scientific evidence reported here validates its traditional use as a biting-insect deterrent.

Oviposition deterrent and skin repellent activities of Solanum trilobatum leaf extract against the malarial vector Anopheles stephensi.

PubMed Central

Rajkumar, S.; Jebanesan, A.

2005-01-01

The leaf extract of Solanum trilobatum (Solanaceae) was tested under laboratory conditions for oviposition deterrent and skin repellent activities against the adult mosquito Anopheles stephensi. Concentrations of 0.01, 0.025, 0.05, 0.075 and 0.1% reduced egg laying by gravid females from 18 to 99% compared to ethanol-treated controls. In skin repellent tests, concentrations of 0.001, 0.005, 0.01, 0.015, and 0.02 % provided 70 to 120 minutes protection against mosquito bites, whereas the ethanol control provided only 2.2 minutes of protection. Both oviposition deterrent and skin repellent activity were dose dependent. The results suggest that the leaf extract of S. trilobatum is an effective oviposition deterrent and skin repellent against An. stephensi. PMID:16341247

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martz, Joseph C; Stevens, Patrice A; Branstetter, Linda

Until very recently, an evaluation of US policy regarding deterrence and the role of its nuclear weapons arsenal as a deterrent has been largely absent in the public debate. With President's Obama embrace of a goal of a future world without nuclear weapons, issues of nuclear policy and deterrence have just recently risen to the forefront of policy discussions. The traditional role of US nuclear weapons-to deter the use of nuclear weapons by other states-endures, but is no longer unique nor even predominant. In an increasingly multi-polar world, the US now faces growing risks of nuclear weapons proliferation; the spreadmore » of weapons of mass destruction generally to non-state, substate and transnational actors; cyber, space, economic, environmental and resource threats along with the application of numerous other forms of 'soft power' in ways that are inimical to national security and to global stability. What concept of deterrence should the US seek to maintain in the 21st Century? That question remains fluid and central to the current debate. Recently there has been a renewed focusing of attention on the role of US nuclear weapons and a national discussion about what the underlying policy should be. In this environment, both the United States and Russia have committed to drastic reductions in their nuclear arsenals, while still maintaining forces sufficient to ensure unacceptable consequence in response to acts of aggression. Further, the declared nuclear powers have maintained that a limited nuclear arsenal continues to provide insurance against uncertain developments in a changing world. In this environment of US and Russian stockpile reductions, all declared nuclear states have reiterated the central role which nuclear weapons continue to provide for their supreme national security interests. Given this new environment and the challenges of the next several decades, how might the United States structure its policy and forces with regard to nuclear weapons? Many competing objectives have been stated across the spectrum of political, social, and military thought. These objectives include goals of ratification of the Comprehensive Test Ban Treaty, recommitment to further downsizing of the nuclear arsenal, embracing a long-term goal of the elimination of nuclear weapons, limitations on both the production complex and upgrades to nuclear weapons and delivery systems, and controls and constraints to limit proliferation of nuclear materials and weapons, particularly to rogue states and terrorist groups.« less

Validation of Rational Deterrence Theory: Analysis of U.S. Government and Adversary Risk Propensity and Relative Emphasis on Gain or Loss

DTIC Science & Technology

2010-03-01

policy (Achen & Snidal, 1989). Huth and Russett (1984) emphasize : “if we do not know how deterrence works when it is most needed, policies assigned...application of deterrence to U.S. adversaries in these policies. Analysis of risk propensity and relative emphases on loss/gain of those actors...research, the strategic environment. Evidence of such assessment may reflect an adversary’s risk propensities and relative emphases on loss/gain; however

Thyrotoxic and pheochromocytoma multisystem crisis: a case report.

PubMed

Suzuki, Kodai; Miyake, Takahito; Okada, Hideshi; Yamaji, Fuminori; Kitagawa, Yuichiro; Fukuta, Tetsuya; Yasuda, Ryu; Tanaka, Yoshihito; Okamoto, Haruka; Nachi, Sho; Doi, Tomoaki; Yoshida, Takahiro; Kumada, Keisuke; Yoshida, Shozo; Ushikoshi, Hiroaki; Toyoda, Izumi; Ogura, Shinji

2017-06-23

Thyrotoxic crisis and pheochromocytoma multisystem crisis are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of a patient who simultaneously developed thyrotoxic crisis and pheochromocytoma multisystem crisis and required intensive cardiovascular management. A 60-year-old Asian man experienced nausea and vomiting, and subsequently developed dyspnea and cold sweats while farming. His serum free thyroxine, free triiodothyronine, and thyrotropin receptor antibody levels were elevated at 2.9 ng/dL, 7.2 pg/dL, and 4.7 IU/L, respectively. Serum thyrotropin levels were suppressed at less than 0.01 μIU/mL. Thyroid echography demonstrated no thyroid swelling (23 × 43 mm). A whole body computed tomography was performed for systemic evaluation. This revealed exophthalmos and a mass of size 57 × 64 mm in the anterior pararenal space. Based on these findings, we made an initial diagnosis of thyrotoxic crisis secondary to exacerbation of Grave's hyperthyroidism. Treatment was begun with an iodine agent at a dose of 36 mg/day, thiamazole at a dose of 30 mg/day, and hydrocortisone at a dose of 300 mg daily for 3 consecutive days. To control tachycardia, continuous intravenously administered propranolol and diltiazem infusions were given. At the same time, small doses of doxazosin and carvedilol were used for both alpha and beta adrenergic blockade. On hospital day 5, his blood pressure and serum catecholamine concentrations (adrenalin 42,365 pg/mL, dopamine 6409 pg/mL, noradrenalin 72,212 pg/mL) were still high despite higher beta blocker and calcium channel blocker doses. These findings contributed to the diagnosis of pheochromocytoma multisystem crisis with simultaneous thyrotoxic crisis. We increased the doses of doxazosin and carvedilol, which stabilized his hemodynamic status. On hospital day 16, metaiodobenzylguanidine scintigraphy showed high accumulation in the right adrenal gland tumor. After retroperitoneal laparoscopic adrenalectomy on hospital day 33, his condition stabilized. He was discharged on hospital day 58. Since he required more intensive cardiovascular management for thyrotoxic crisis, beta blockade was increased under intensive care unit monitoring even though initial alpha blockade is recommended in pheochromocytoma. When these crises occur simultaneously, cardiovascular management can be very challenging.

The Affordable Housing Crisis: Residential Mobility of Poor Families and School Mobility of Poor Children.

ERIC Educational Resources Information Center

Crowley, Sheila

2003-01-01

Helping poor families increase their residential stability can have direct bearing on school stability and student academic achievement. Discusses the role of housing in child and family wellbeing; residential mobility and school performance; residential mobility and housing problems; housing affordability; (federal housing policy); homeownership;…

U.S. Regional Deterrence Strategies

DTIC Science & Technology

1995-01-01

MOTIVATIONS OF REGIONAL ADVERSARIES ............................. 27 Regime Types ................................. 27 Domestic Political Instability...32 Historical Cases Illustrating the influence of Domestic Politics .................................. 36 China, 1950... Political Constraints ............................. 86 Military Constraints ............. II................89 Deterrence in U.S. Regional Strategy

Deterrence before Hiroshima

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quester, G.H.

The gap between studies of military history and military strategy is ever widening. The enormous destructive power of nuclear weapons has tended to persuade us that the military experience of the first half of this century is not relevant to more ''modern'' military questions. In Deterrence before Hiroshima, first published in 1966, George H. Quester analyzes pre-nuclear age theories of deterrence to equip us with a perspective and data by which current theories can be evaluated. Quester shows that from almost the time of the first military aircraft, air-power was believed to have the capacity for apocalyptic destruction. He pointsmore » out that the modern terms deterrence, limited war, tacit agreement, and balance of terror, show up often in the literature from 1900-1945, coupled with war scenarios every bit as awesome as a nuclear holocaust.« less

Effect of qualitative and quantitative variation in allelochemicals on a generalist insect: Iridoid glycosides and the southern armyworm.

PubMed

Puttick, G M; Bowers, M D

1988-01-01

The behavioral and physiological effects of plant allelochemicals have been difficult to demonstrate; it is not often clear whether the compounds are deterrent, toxic, or both. In this study, we compared the qualitative and quantitative effects of several iridoid glycosides on a generalist lepidopteran herbivore,Spodoptera eridania (Noctuidae). Larval growth and survivorship and larval preference or avoidance were measured on artificial diets containing different iridoid glycosides at different concentrations. We also tested the toxicity/deterrence of these compounds. We found that iridoid glycosides retarded larval growth significantly at relatively low concentrations and that they were usually avoided in preference tests. The toxicity/ deterrence test did not always reflect the results of these other tests. The merits of using a variety of methods for determining deterrence and/or toxicity of plant allelochemicals are discussed.

Age, gender and deterrability: Are younger male drivers more likely to discount the future?

PubMed

Freeman, James; Kaye, Sherrie-Anne; Truelove, Verity; Davey, Jeremy

2017-07-01

Utilizing the Classical Deterrence theory and Stafford and Warr's (1993) reconceptualized model of deterrence, the current study examined whether age, gender, and discounting the future tendencies influence perceptions of being apprehended for speeding offences. Licensed motorists (N=700; 57% female) in Queensland (Australia) were recruited to complete a self-report questionnaire that measured perceptual deterrence, speeding related behaviors and discounting the future tendencies. Data were analyzed utilizing descriptive, bivariate and multivariate regressions. Significant (albeit weak) positive correlations were found between age and perceptions of apprehension certainty. Males were significantly more likely to report higher incidences of speeding (including while avoiding detection) compared to females. In contrast, females were more likely to perceive high levels of apprehension certainty and consider impending penalties to be more severe. At a multivariate level, discounting the future tendencies (in addition to being male, reporting lower levels of perceptual severity and swiftness, and more instances of punishment avoidance) were predictive of lower perceptual certainty levels. This study is one of the first to reveal that being male and having a tendency to discount the consequences of the future may directly influence drivers' perceptual deterrence levels. Copyright © 2017 Elsevier Ltd. All rights reserved.

Summary Report - Strategic Weapons on the 21st Century Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, B.

2017-04-21

This 11th annual event focused on changes in the security environment and their implications for the U.S. approach to deterrence, with special attention to extended deterrence in Europe and East Asia.

Deterrents to Change.

ERIC Educational Resources Information Center

Dyer, John

1984-01-01

Identifies some of the current forces influencing global change; speculates on possible ramifications of these forces for changes in a school system; and suggests what possible deterrents and inhibitors operating in large public education systems are preventing change. (SB)

Strategic, Tactical and Doctrinal Military Concepts. The Deterrence Concept: A Synthesis Based on a Survey of the Literature.

DTIC Science & Technology

1980-04-01

influence appears strongest, that the work is most ab - stract, and that the results have seemed to cause the most prob- lems when applied to the real...deterrence to the world at large, for Churchill’s clear exposi - tion of the basic concept, and as probably the first major statement on deterrence...works cited are in general ab - stract and theoretical, or minor and irrelevant. Also, since most of the bibliography cited is from the 1950’s (a single

Taste detection of the non-volatile isothiocyanate moringin results in deterrence to glucosinolate-adapted insect larvae.

PubMed

Müller, Caroline; van Loon, Joop; Ruschioni, Sara; De Nicola, Gina Rosalinda; Olsen, Carl Erik; Iori, Renato; Agerbirk, Niels

2015-10-01

Isothiocyanates (ITCs), released from Brassicales plants after hydrolysis of glucosinolates, are known for their negative effects on herbivores but mechanisms have been elusive. The ITCs are initially present in dissolved form at the site of herbivore feeding, but volatile ITCs may subsequently enter the gas phase and all ITCs may react with matrix components. Deterrence to herbivores resulting from topically applied volatile ITCs in artificial feeding assays may hence lead to ambiguous conclusions. In the present study, the non-volatile ITC moringin (4-(α-L-rhamnopyranosyloxy)benzyl ITC) and its glucosinolate precursor glucomoringin were examined for effects on behaviour and taste physiology of specialist insect herbivores of Brassicales. In feeding bioassays, glucomoringin was not deterrent to larvae of Pieris napi (Lepidoptera: Pieridae) and Athalia rosae (Hymenoptera: Tenthredinidae), which are adapted to glucosinolates. Glucomoringin stimulated feeding of larvae of the related Pieris brassicae (Lepidoptera: Pieridae) and also elicited electrophysiological activity from a glucosinolate-sensitive gustatory neuron in the lateral maxillary taste sensilla. In contrast, the ITC moringin was deterrent to P. napi and P. brassicae at high levels and to A. rosae at both high and low levels when topically applied to cabbage leaf discs (either 12, 120 or 1200 nmol moringin per leaf disc of 1cm diameter). Survival of A. rosae was also significantly reduced when larvae were kept on leaves treated with moringin for several days. Furthermore, moringin elicited electrophysiological activity in a deterrent-sensitive neuron in the medial maxillary taste sensillum of P. brassicae, providing a sensory mechanism for the deterrence and the first known ITC taste response of an insect. In simulated feeding assays, recovery of moringin was high, in accordance with its non-volatile nature. Our results demonstrate taste-mediated deterrence of a non-volatile, natural ITC to glucosinolate-adapted insects. Copyright © 2015 Elsevier Ltd. All rights reserved.

What deters nurses from participating in web-based graduate nursing programs?: A cross-sectional survey research study.

PubMed

Carpenter, Suzanne H

2016-01-01

A graduate degree is required of nursing faculty in America. Because of the nursing faculty shortage, web-based graduate nursing programs are being offered to encourage nurses to return to school. The identification of deterrents to participating in these programs is an important step in increasing enrollment. To identify deterrents to participation in web-based graduate nursing programs. Descriptive survey research. Louisiana Two hundred and eighty-one registered nurse members of the Louisiana Nurses' Association. The 54-item four-point Likert-type interval scale Deterrents to Participation in Web-Based Graduate Nursing Programs Survey Instrument was used. Data were collected over 8weeks using SurveyMonkey.com to administer the web survey tool to all members of the Louisiana State Nurses' Association. A factor analysis revealed a three-factor solution that explained 55.436% of the total variance in deterrents to participation in web-based graduate nursing programs. The factors were labeled "concerns about quality, cost, and time," "concerns about access to resources: technological and personal," and "concerns about electronic mediated communication." Multiple regression analysis revealed an overall model of three predictors of deterrents to participation in web-based graduate nursing programs: no computer literacy, annual household income between 20,000 and 50,000 dollars, and having the current educational status of graduating from a diploma RN program. This model accounted for 21% of the variance in the deterrents to participation scores. Since these three significant predictors of deterrents to participation in web-based graduate nursing programs were identified, web-based nursing graduate program administrators might consider an outreach to RN diploma graduates in an effort to make them aware of available technology support programs to foster participation. Scholarships for lower income nursing students are recommended, and programs to support computer literacy within the nursing community should be considered. Copyright © 2015 Elsevier Ltd. All rights reserved.

(E)-Caryophyllene and α-Humulene: Aedes aegypti Oviposition Deterrents Elucidated by Gas Chromatography-Electrophysiological Assay of Commiphora leptophloeos Leaf Oil

PubMed Central

da Silva, Rayane Cristine Santos; Milet-Pinheiro, Paulo; Bezerra da Silva, Patrícia Cristina; da Silva, Alexandre Gomes; da Silva, Marcia Vanusa; Navarro, Daniela Maria do Amaral Ferraz; da Silva, Nicácio Henrique

2015-01-01

Aedes aegypti is responsible for the transmission of dengue, a disease that infects millions of people each year. Although essential oils are well recognized as sources of compounds with repellent and larvicidal activities against the dengue mosquito, much less is known about their oviposition deterrent effects. Commiphora leptophloeos, a tree native to South America, has important pharmacological properties, but the chemical profile and applicability of its essential oil in controlling the spread of the dengue mosquito have not been investigated. The aim of this study was to determine the composition of C. leptophloeos leaf oil and to evaluate its larvicidal and oviposition deterrent effects against A. aegypti. Fifty-five components of the essential oil were detected by gas chromatography (GC)—mass spectrometry, with α-phellandrene (26.3%), (E)-caryophyllene (18.0%) and β-phellandrene (12.9%) identified as the major constituents. Bioassays showed that the oil exhibited strong oviposition deterrent effects against A. aegypti at concentrations between 25 and 100 ppm, and possessed good larvicidal activity (LC50 = 99.4 ppm). Analysis of the oil by GC coupled with electroantennographic detection established that seven constituents could trigger antennal depolarization in A. aegypti gravid females. Two of these components, namely (E)-caryophyllene and α-humulene, were present in substantial proportions in the oil, and oviposition deterrence assays confirmed that both were significantly active at concentrations equivalent to those present in the oil. It is concluded that these sesquiterpenes are responsible, at least in part, for the deterrent effect of the oil. The oviposition deterrent activity of the leaf oil of C. leptophloeos is one of the most potent reported so far, suggesting that it could represent an interesting alternative to synthetic insecticides. The results of this study highlight the importance of integrating chemical and electrophysiological methods for screening natural compounds for their potential in combating vectors of insect-borne diseases. PMID:26650757

Provider-Payer Partnerships as an Engine for Continuous Quality Improvement.

PubMed

Balfour, Margaret E; Zinn, Tylar E; Cason, Karena; Fox, Jerimya; Morales, Myra; Berdeja, Cesar; Gray, Jay

2018-06-01

The authors describe a quality improvement approach in which a crisis center and a payer collaborate to improve care. Each crisis visit is considered as a potentially missed opportunity for community stabilization. Daily data on crisis visits are sent to the payer for a more up-to-date analysis of trends than is possible with financial claims data, which may lag behind services provided by up to 90 days. Using these trend data, the two organizations collaborate to identify patterns that lead to opportunities for improvement and develop multiple rapid-cycle projects for better management of services, resulting in significant decreases in readmissions and in the number of high utilizers.

Deterrent activity of hops flavonoids and their derivatives against stored product pests.

PubMed

Jackowski, J; Popłoński, J; Twardowska, K; Magiera-Dulewicz, J; Hurej, M; Huszcza, E

2017-10-01

Five flavonoids from hops, two of their derivatives, along with naringenin used as a model compound, were tested for their antifeedant activity against three coleopteran stored product pests: Sitophilus granarius L., Tribolium confusum Duv. and Trogoderma granarium Everts. The introduction, into the tested flavonoid molecules, of additional structural fragments such as prenyl or dimethylpyran moiety, is proposed to significantly alter the deterrent activity of the compounds. The prenyl moiety in flavonoids increased the deterrent activity of these compounds in all three of the grain feeding species used in the tests. It is also concluded that the introduction of dimethylpyran moiety to the flavonoid structure increases its deterrent activity in S. granarius and T. confusum, but in one of the test insects, T. granarium, an increased feeding was observed in response to the introduction of dimethylpyran moiety to the flavonoid structure.

Leidenfrost vapour layer moderation of the drag crisis and trajectories of superhydrophobic and hydrophilic spheres falling in water.

PubMed

Vakarelski, Ivan U; Chan, Derek Y C; Thoroddsen, Sigurdur T

2014-08-21

We investigate the dynamic effects of a Leidenfrost vapour layer sustained on the surface of heated steel spheres during free fall in water. We find that a stable vapour layer sustained on the textured superhydrophobic surface of spheres falling through 95 °C water can reduce the hydrodynamic drag by up to 75% and stabilize the sphere trajectory for the Reynolds number between 10(4) and 10(6), spanning the drag crisis in the absence of the vapour layer. For hydrophilic spheres under the same conditions, the transition to drag reduction and trajectory stability occurs abruptly at a temperature different from the static Leidenfrost point. The observed drag reduction effects are attributed to the disruption of the viscous boundary layer by the vapour layer whose thickness depends on the water temperature. Both the drag reduction and the trajectory stabilization effects are expected to have significant implications for development of sustainable vapour layer based technologies.

The Longitudinal Effects of Residential Mobility on the Academic Achievement of Urban Elementary and Middle School Students

ERIC Educational Resources Information Center

Voight, Adam; Shinn, Marybeth; Nation, Maury

2012-01-01

Residential stability matters to a young person's educational development, and the present housing crisis has disrupted the residential stability of many families. This study uses latent growth-curve modeling to examine how changing residences affects math and reading achievement from third through eighth grade among a sample of urban elementary…

Stock network stability in times of crisis

NASA Astrophysics Data System (ADS)

Heiberger, Raphael H.

2014-01-01

Despite many efforts crises on financial markets are in large part still scientific black-boxes. In this paper, we use a winner-take-all approach to construct a longitudinal network of S&P 500 companies and their correlations between 2000 and 2012. A comparison to complex ecosystems is drawn, especially whether the May-Wigner theorem can describe real-world economic phenomena. The results confirm the utility of the May-Wigner theorem as a stability indicator for the US stock market, since its development matches with the two major crises of this period, the dot-com bubble and, particularly, the financial crisis. In those times of financial turmoil, the stock network changes its composition, but unlike ecological systems it tightens and the disassortative structure of prosperous markets transforms into a more centralized topology.

Field evaluation of jail sanctions for DWI

DOT National Transportation Integrated Search

1988-04-29

The objective of this study was to evaluate the effect of Tennessee's two-day mandatory jail sanction for first-offense DWI on general deterrence, special deterrence, and the operation of the drinking-driver control system. Our analysis of general de...

U.S. Economic Strategy in Shaping Mexico - Living Happily Ever NAFTA.

DTIC Science & Technology

1998-05-09

DOCTRINE IN THE HOUSE? 21 A U.S. Peso Crisis? 21 U.S. Promotion of Labor Reform 24 v U.S. STRATEGY - LINKING ENDS, WAYS AND MEANS 26 CONCLUSION...part to devaluation of the peso . Percentage changes calculated in local currency- Merchandise trade 5 Source: U.S. Department of Commerce and U.S...Mexico’s economic or political stability. A similar rationale can be applied to understanding the motive for U.S. assistance during the Peso Crisis of

Crisis management can leave residual effects.

PubMed

Margolis, G L; DeMuro, P R

1991-10-01

A healthcare organization that once suffered from poor financial performance may fail to correct recovery methods that can cause lingering legal and accounting problems. A crisis management style is prone to creating problems with an organization's debt structure, Medicare and Medicaid payment, tax issues, labor relations, licensing and accreditation, compliance with fraud and abuse rules, and accounting for charity care. After stabilizing a worrisome financial situation, a healthcare organization should conduct an internal audit to ensure that its legal and accounting practices remain above board.

Germany and the Future of Nuclear Deterrence in Europe

DTIC Science & Technology

1992-12-01

OF GERMANY PRIOR TO REUNIFICATION ........................................ 10 A. INTRODUCTION .................................... 10 B . 1945-1960...Strategic Thinking and the Role of Franz Josef Strauss ..................................... 19 b . Domestic and International Opposition ............ 23 c...63 B . UNITED KINGDOM .................................. 63 1. Background of Deterrence ........................... 64 2

The general deterrence of driving while intoxicated. Volume 2, Subsystem analyses

DOT National Transportation Integrated Search

1978-04-01

A system analysis was completed of the general deterrence of driving while intoxicated (DWI). Elements which influence DWI 'decisions were identified and interrelated in a system model; then, potential countermeasures which might be employed in DWI g...

Enforcement and public information strategies for DWI deterrence : the Indianapolis, Indiana experience

DOT National Transportation Integrated Search

1988-07-01

This report summarizes the results of a field test of attempting to achieve driving while intoxicated (DWI) general deterrence by combining enforcement efforts with public information and education (PI&E) activities designed to heighten public awaren...

Little Boy to Star Wars the evolution of American deterrence. Research report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Havey, M.E.

1986-05-01

The historical and sociological development of the American deterrent posture in the nuclear age is traced since the its dawn at Alamagordo, New Mexico, 16 July 1945, and the use of the Little Boy over Hiroshima three weeks later. A description of Western man's involvement in and reaction to pre-1945 catastrophic circumstances is followed by a comparative examination of the post-1945 changes in national policy in regard to the use and dangers of total war. Using Bernard Brodie as a theoretical deterrent baseline, the author analyzes the ethical and military shifts in U.S. declaratory (versus actual) nuclear policy, through Paulmore » Nitze's statements of future policy in light of strategic defense. The author concludes that extremely effective--not necessarily perfect--defenses can be based dramatically on the beneficial effects of arms control. But at the same time, such a condition must inevitably result in a de facto reversion of U.S. nuclear policy to that of a small, non-counterforce force de frappe deterrent - similar in effect to that of the present French posture. The implications of this upon U.S.-Soviet force balance, the historical trends of the American Way of War, and the present deterrent mindset of the officer corps is left as a grave concern.« less

Bumblebees are not deterred by ecologically relevant concentrations of nectar toxins.

PubMed

Tiedeken, Erin Jo; Stout, Jane C; Stevenson, Philip C; Wright, Geraldine A

2014-05-01

Bees visit flowers to collect nectar and pollen that contain nutrients and simultaneously facilitate plant sexual reproduction. Paradoxically, nectar produced to attract pollinators often contains deterrent or toxic plant compounds associated with herbivore defence. The functional significance of these nectar toxins is not fully understood, but they may have a negative impact on pollinator behaviour and health, and, ultimately, plant pollination. This study investigates whether a generalist bumblebee, Bombus terrestris, can detect naturally occurring concentrations of nectar toxins. Using paired-choice experiments, we identified deterrence thresholds for five compounds found in the nectar of bee-pollinated plants: quinine, caffeine, nicotine, amygdalin and grayanotoxin. The deterrence threshold was determined when bumblebees significantly preferred a sucrose solution over a sucrose solution containing the compound. Bumblebees had the lowest deterrence threshold for the alkaloid quinine (0.01 mmol l(-1)); all other compounds had higher deterrence thresholds, above the natural concentration range in floral nectar. Our data, combined with previous work using honeybees, suggest that generalist bee species have poor acuity for the detection of nectar toxins. The fact that bees do not avoid nectar-relevant concentrations of these compounds likely indicates that it is difficult for them to learn to associate floral traits with the presence of toxins, thus maintaining this trait in plant populations.

Bumblebees are not deterred by ecologically relevant concentrations of nectar toxins

PubMed Central

Tiedeken, Erin Jo; Stout, Jane C.; Stevenson, Philip C.; Wright, Geraldine A.

2014-01-01

Bees visit flowers to collect nectar and pollen that contain nutrients and simultaneously facilitate plant sexual reproduction. Paradoxically, nectar produced to attract pollinators often contains deterrent or toxic plant compounds associated with herbivore defence. The functional significance of these nectar toxins is not fully understood, but they may have a negative impact on pollinator behaviour and health, and, ultimately, plant pollination. This study investigates whether a generalist bumblebee, Bombus terrestris, can detect naturally occurring concentrations of nectar toxins. Using paired-choice experiments, we identified deterrence thresholds for five compounds found in the nectar of bee-pollinated plants: quinine, caffeine, nicotine, amygdalin and grayanotoxin. The deterrence threshold was determined when bumblebees significantly preferred a sucrose solution over a sucrose solution containing the compound. Bumblebees had the lowest deterrence threshold for the alkaloid quinine (0.01 mmol l−1); all other compounds had higher deterrence thresholds, above the natural concentration range in floral nectar. Our data, combined with previous work using honeybees, suggest that generalist bee species have poor acuity for the detection of nectar toxins. The fact that bees do not avoid nectar-relevant concentrations of these compounds likely indicates that it is difficult for them to learn to associate floral traits with the presence of toxins, thus maintaining this trait in plant populations. PMID:24526720

[Economics and equity in urgency and emergency care].

PubMed

Moreno-Millán, E; Tejedor-Fernández, M; Torres-Murillo, J M; García-Torrecillas, J M; Cid-Cumplido, M; Villegas-del Ojo, J; García-Fernández, A M

2010-01-01

The financial sustainability of public health systems (PHS) is currently threatened by population growth, increased prevalence of chronic conditions and disabilities, inequality in access and use of resources, zero cost delivery and global economic crisis. The emergency department (ED) is one for which demand is highest--without relation to the health model--because disease becomes established in disadvantaged socio-demographic areas and inequalities, hyperconsumption and decision making more closely linked to the user are maintained. The medical device of ED is a multiple one and its diverse product lines make it difficult to measure. This review discusses the need to deploy measurement tools in ED, where there are high direct costs--primarily structural--and other variables related to the activity, where the marginal cost is higher than the average and there is no economy of scale in such interventions. The possible mechanisms of private copayment in financing the supply of EDs are also studied, showing their advantages and disadvantages, with the conclusion that they are not recommendable--due to their scarce fund raising and deterrent capacity, which is why fundamental strategic changes in the management of these resources are needed.

Structure and Connectivity Analysis of Financial Complex System Based on G-Causality Network

NASA Astrophysics Data System (ADS)

Xu, Chuan-Ming; Yan, Yan; Zhu, Xiao-Wu; Li, Xiao-Teng; Chen, Xiao-Song

2013-11-01

The recent financial crisis highlights the inherent weaknesses of the financial market. To explore the mechanism that maintains the financial market as a system, we study the interactions of U.S. financial market from the network perspective. Applied with conditional Granger causality network analysis, network density, in-degree and out-degree rankings are important indicators to analyze the conditional causal relationships among financial agents, and further to assess the stability of U.S. financial systems. It is found that the topological structure of G-causality network in U.S. financial market changed in different stages over the last decade, especially during the recent global financial crisis. Network density of the G-causality model is much higher during the period of 2007-2009 crisis stage, and it reaches the peak value in 2008, the most turbulent time in the crisis. Ranked by in-degrees and out-degrees, insurance companies are listed in the top of 68 financial institutions during the crisis. They act as the hubs which are more easily influenced by other financial institutions and simultaneously influence others during the global financial disturbance.

Arthropod deterrents from Artemisia pallens (Davana oil) components

USDA-ARS?s Scientific Manuscript database

Davanone, a key sesquiterpene component of davana oil, has been synthesized in five convenient steps. Oxygenated sesquiterpenes have been linked to insect deterrent properties. Based on initial screening of davana oil, davanone and its hydroxy precursors have been generated and are being evaluated...

Enforcement and public information strategies for DWI general deterrence : the Boise City, Idaho experience

DOT National Transportation Integrated Search

1987-08-01

This report summarizes the results of a field test of attempting to achieve driving while intoxicated (DWI) general deterrence by combining enforcement efforts with public information and education (PI&E) activities designed to heighten public awaren...

Use of intermediaries in DWI deterrence. Volume 1, Phase 2 report : development of intermediary programs

DOT National Transportation Integrated Search

1983-04-01

One potential approach to DWI deterrence and prevention involves encouraging people present in potential drunk driving situations to intervene in order to prevent a trip by an impaired driver. Potential "intermediaries" include service personnel in c...

Routes of abuse of prescription opioid analgesics: a review and assessment of the potential impact of abuse-deterrent formulations.

PubMed

Gasior, Maciej; Bond, Mary; Malamut, Richard

2016-01-01

Prescription opioid analgesics are an important treatment option for patients with chronic pain; however, misuse, abuse and diversion of these medications are a major global public health concern. Prescription opioid analgesics can be abused via intended and non-intended routes of administration, both intact or after manipulation of the original formulation to alter the drug-delivery characteristics. Available data indicate that ingestion (with or without manipulation of the prescribed formulation) is the most prevalent route of abuse, followed by inhalation (snorting, smoking and vaping) and injection. However, reported routes of abuse vary considerably between different formulations. A number of factors have been identified that appear to be associated with non-oral routes of abuse, including a longer duration of abuse, younger age, male sex and a rural or socially deprived location. The development of abuse-deterrent formulations of prescription opioid analgesics is an important step toward reducing abuse of these medications. Available abuse-deterrent formulations aim to hinder extraction of the active ingredient, prevent administration through alternative routes and/or make abuse of the manipulated product less attractive, less rewarding or even aversive. There are currently five opioid analgesics with a Food and Drug Administration abuse-deterrent label, and a number of other products are under review. A growing body of evidence suggests that introduction of abuse-deterrent opioid analgesics in the USA has been associated with decreased rates of abuse of these formulations. The availability of abuse-deterrent formulations therefore appears to represent an important step toward curbing the epidemic of abuse of prescription opioid analgesics, while ensuring the availability of effective pain medications for patients with legitimate medical need.

Mitigating the Impact of Bats in Historic Churches: The Response of Natterer’s Bats Myotis nattereri to Artificial Roosts and Deterrence

PubMed Central

Zeale, Matt R. K.; Bennitt, Emily; Newson, Stuart E.; Packman, Charlotte; Browne, William J.; Harris, Stephen; Jones, Gareth; Stone, Emma

2016-01-01

Bats frequently roost in historic churches, and these colonies are of considerable conservation value. Inside churches, bat droppings and urine can cause damage to the historic fabric of the building and to items of cultural significance. In extreme cases, large quantities of droppings can restrict the use of a church for worship and/or other community functions. In the United Kingdom, bats and their roosts are protected by law, and striking a balance between conserving the natural and cultural heritage can be a significant challenge. We investigated mitigation strategies that could be employed in churches and other historic buildings to alleviate problems caused by bats without adversely affecting their welfare or conservation status. We used a combination of artificial roost provision and deterrence at churches in Norfolk, England, where significant maternity colonies of Natterer’s bats Myotis nattereri damage church features. Radio-tracking data and population modelling showed that excluding M. nattereri from churches is likely to have a negative impact on their welfare and conservation status, but that judicious use of deterrents, especially high intensity ultrasound, can mitigate problems caused by bats. We show that deterrence can be used to move bats humanely from specific roosting sites within a church and limit the spread of droppings and urine so that problems to congregations and damage to cultural heritage can be much reduced. In addition, construction of bespoke roost spaces within churches can allow bats to continue to roost within the fabric of the building without flying in the church interior. We highlight that deterrence has the potential to cause serious harm to M. nattereri populations if not used judiciously, and so the effects of deterrents will need careful monitoring, and their use needs strict regulation. PMID:26771548

Important statistical considerations in the evaluation of post-market studies to assess whether opioids with abuse-deterrent properties result in reduced abuse in the community.

PubMed

By, Kunthel; McAninch, Jana K; Keeton, Stephine L; Secora, Alex; Kornegay, Cynthia J; Hwang, Catherine S; Ly, Thomas; Levenson, Mark S

2018-05-01

Abuse, misuse, addiction, overdose, and death associated with non-medical use of prescription opioids have become a serious public health concern. Reformulation of these products with abuse-deterrent properties is one approach for addressing this problem. FDA has approved several extended-release opioid analgesics with abuse-deterrent labeling, the bases of which come from pre-market studies. As all opioid analgesics must be capable of delivering the opioid in order to reduce pain, abuse-deterrent properties do not prevent abuse, nor do pre-market evaluations ensure that there will be reduced abuse in the community. Utilizing data from various surveillance systems, some recent post-market studies suggest a decline in abuse of extended-release oxycodone after reformulation with abuse-deterrent properties. We discuss challenges stemming from the use of such data. We quantify the relationship between the sample, the population, and the underlying sampling mechanism and identify the necessary conditions if valid statements about the population are to be made. The presence of other interventions in the community necessitates the use of comparators. We discuss the principles under which the use of comparators can be meaningful. Results based on surveillance data need to be interpreted with caution as the underlying sampling mechanisms can bias the results in unpredictable ways. The use of comparators has the potential to disentangle the effect due to the abuse-deterrence properties from those due to other interventions. However, identifying a comparator that is meaningful can be very difficult. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

Deterrence at the Operational Level of War

DTIC Science & Technology

2011-01-01

edited, with Barry Blechman, Making Defense Reform Work (Brassey’s, 1990) and has also authored numerous books and articles . Deterrence at the...computational power. In contrast, many models of rational inference view the mind as if it were a supernatural being possessing demonic powers of reason

Deterrents to Participation in Web-based Continuing Professional Education.

ERIC Educational Resources Information Center

Perdue, Kathy J.; Valentine, Thomas

2000-01-01

This study examined the perceptions of certified public accountants concerning deterrents to participation in Web-based continuing professional education. Results of surveys included concerns about electronically mediated communication; the quality of course offerings; access to technology-associated resources; and the availability of necessary…

The general deterrence of driving while intoxicated. Volume 1, System analysis and computer-based simulation

DOT National Transportation Integrated Search

1978-01-01

A system analysis was completed of the general deterrence of driving while intoxicated (DWI). Elements which influence DWI decisions were identified and interrelated in a system model; then, potential countermeasures which might be employed in DWI ge...

Task force on deterrence of air piracy : final report.

DOT National Transportation Integrated Search

1978-11-01

In February 1969, as the frequency of hijacking of U.S. air carrier aircraft was rising to an all-time high, the Federal Aviation Administration established a multi-disciplinary Task Force on Deterrence of Air Piracy. The work of the Task Force in de...

Give Deterrence a Chance: A Strategy Against Al Qaeda

DTIC Science & Technology

2007-03-28

Al Qaeda Terrorists have been described as sociopaths , narcissists, fanatics, extremists, zealots, true-believers, jihadists or demented criminals...If terrorists are sociopaths or other deviants (and it is probable that some are), then it is unlikely that deterrence with its reliance on rational

Nectar Attracts Foraging Honey Bees with Components of Their Queen Pheromones.

PubMed

Liu, Fanglin; Gao, Jie; Di, Nayan; Adler, Lynn S

2015-11-01

Floral nectar often contains chemicals that are deterrent to pollinators, presenting potential challenges to outcrossing plant species. Plants may be able to co-opt pollinator chemical signals to mitigate the negative effects of nectar deterrent compounds on pollination services. We found that buckwheat (Fagopyrum esculentum) and Mexican sunflower (Tithonia diversifolia) produce nectar with abundant phenolics, including three components of the Apis honeybee queen mandibular pheromone (QMP). In addition, these nectars contain a non-pheromonal phenolic, chlorogenic acid (CA), which was toxic to honeybees, and T. diversifolia nectar also contained isochlorogenic acid (IA). Fresh nectar or solutions containing nectar phenolics reduced Apis individual feeding compared to sucrose solutions. However, freely foraging bees preferred solutions with QMP components to control solutions, and QMP components over-rode or reversed avoidance of CA and IA. Furthermore, prior exposure to the presence or just the odor of QMP components removed the deterrent effects of CA and IA. By mimicking the honey bee pheromone blend, nectar may maintain pollinator attraction in spite of deterrent nectar compounds.

The effect of an abuse‐deterrent opioid formulation (OxyContin) on opioid abuse‐related outcomes in the postmarketing setting

PubMed Central

Chilcoat, HD; Butler, SF; Sellers, EM; Kadakia, A; Harikrishnan, V; Haddox, JD; Dart, RC

2016-01-01

An extended‐release opioid analgesic (OxyContin, OC) was reformulated with abuse‐deterrent properties to deter abuse. This report examines changes in abuse through oral and nonoral routes, doctor‐shopping, and fatalities in 10 studies 3.5 years after reformulation. Changes in OC abuse from 1 year before to 3 years after OC reformulation were calculated, adjusted for prescription changes. Abuse of OC decreased 48% in national poison center surveillance systems, decreased 32% in a national drug treatment system, and decreased 27% among individuals prescribed OC in claims databases. Doctor‐shopping for OC decreased 50%. Overdose fatalities reported to the manufacturer decreased 65%. Abuse of other opioids without abuse‐deterrent properties decreased 2 years later than OC and with less magnitude, suggesting OC decreases were not due to broader opioid interventions. Consistent with the formulation, decreases were larger for nonoral than oral abuse. Abuse‐deterrent opioids may mitigate abuse and overdose risks among chronic pain patients. PMID:27170195

Larvicidal and Biting Deterrent Activity of Essential Oils of Curcuma longa, Ar-turmerone, and Curcuminoids Against Aedes aegypti and Anopheles quadrimaculatus (Culicidae: Diptera).

PubMed

Ali, Abbas; Wang, Yan-Hong; Khan, Ikhlas A

2015-09-01

Essential oils and extract of Curcuma longa, ar-turmerone, and curcuminoids were evaluated for their larvicidal and deterrent activity against mosquitoes. Ar-turmerone and curcuminoids constituted 36.9, 24.9 and 50.6% of rhizome oil, leaf oil, and rhizome extract, respectively. Ar-turmerone was the major compound of the rhizome oil (36.9%) and leaf oil (24.9%). The ethanolic extract had 15.4% ar-turmerone with 6.6% bisdesmethoxycurcumin, 6.1% desmethoxycurcumin, and 22.6% curcumin. In in vitro studies, essential oils of the leaf (biting deterrence index [BDI] = 0.98), rhizome (BDI = 0.98), and rhizome ethanolic extract (BDI = 0.96) at 10 µg/cm(2) showed biting deterrent activity similar to DEET at 25 nmol/cm(2) against Aedes aegypti L. Among the pure compounds, ar-turmerone (BDI = 1.15) showed the biting deterrent activity higher than DEET at 25 nmol/cm(2) whereas the activity of other compounds was lower than DEET. In Anopheles quadrimaculatus Say, only ar-turmerone showed deterrent activity similar to DEET. In dose-response bioassay, ar-turmerone showed significantly higher biting deterrence than DEET at all the dosages. Ar-turmerone, at 15 nmol/cm(2), showed activity similar to DEET at 25 nmol/cm(2) and activity at 5 nmol/cm(2) was similar to DEET at 20 and 15 nmol/cm(2). Leaf essential oil with LC(50) values of 1.8 and 8.9 ppm against larvae of An. quadrimaculatus and Ae. aegypti, respectively, showed highest toxicity followed by rhizome oil and ethanolic extract. Among the pure compounds, ar-turmerone with LC(50) values of 2.8 and 2.5 ppm against larvae of An. quadrimaculatus and Ae. aegypti, respectively, was most toxic followed by bisdesmethoxycurcumin, curcumin, and desmethoxycurcumin. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A summary of impacts of wind power integration on power system small-signal stability

NASA Astrophysics Data System (ADS)

Yan, Lei; Wang, Kewen

2017-05-01

Wind power has been increasingly integrated into power systems over the last few decades because of the global energy crisis and the pressure on environmental protection, and the stability of the system connected with wind power is becoming more prominent. This paper summaries the research status, achievements as well as deficiencies of the research on the impact of wind power integration on power system small-signal stability. In the end, the further research needed are discussed.

Nuclear weapons, irrational behavior, and extended deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rhodes, E.J.

1985-01-01

This dissertation examines the problem of extended deterrence deductively develops a theory of commitment-through-contingent irrationality, and draws upon this theory to frame a set of comparatively attractive policy recommendations. To these ends, the dissertation explores the nature, sources, and types of irrationality and irrational behavior, the necessary and sufficient conditions for the existence of coercive power, the various logical modes of commitment, and the various modes of nuclear coercion. These strands are fused into a theory of nuclear coercion based on contingently irrational behavior that has relevance for the problem of extended deterrence and that has important implications for USmore » policy.« less

Enforcement, adjudication and public information strategies for the general deterrence of driving while intoxicated : information for potential field site participants

DOT National Transportation Integrated Search

1982-10-01

The National Highway Traffic Safety Administration (NHTSA) through a contract with the University of North Carolina Highway Safety Research Center (HSRC) is intending to field test the effectiveness of selected general deterrence programs directed at...

Do deterrence and social-control theories predict driving after drinking 15 years after a DWI conviction?

PubMed

Lapham, Sandra C; Todd, Michael

2012-03-01

This study investigates the utility of deterrence and social-control theories for prospective prediction of driving-while-impaired (DWI) outcomes of first-time DWI offenders. The sample consisted of a subset of 544 convicted first-time DWI offenders (N=337 females) who were interviewed 5 and 15 years after referral to a Screening Program in Bernalillo County, New Mexico. Variables collected at the 5-year (initial) interview were used in structural equation models to predict past 3-months, self-reported DWI at the 15-year follow-up (follow-up) interview. These variables represented domains defined by deterrence and social-control theories of DWI behavior, with one model corresponding to deterrence theory and one to social-control theory. Both models fit the data. DWI jail time was positively related to perceived enforcement, which was negatively but not significantly related to self-reported DWI. Neither jail time for DWI nor perceived likelihood of arrest was linearly related to self-reported DWI at follow-up. Interactions between jail time and prior DWI behavior indicated relatively weaker associations between initial and 15-year DWI for those reporting more jail time. Our prospective study demonstrated that for this convicted DWI offender cohort, classic formulations of deterrence and social-control theories did not account for DWI. However, results suggest that punishment may decrease the likelihood of DWI recidivism. Copyright © 2012 Elsevier Ltd. All rights reserved.

Do abuse deterrent opioid formulations work?

PubMed

Dart, Richard C; Iwanicki, Janetta L; Dasgupta, Nabarun; Cicero, Theodore J; Schnoll, Sidney H

We performed a systematic review to answer the question, "Does the introduction of an opioid analgesic with abuse deterrent properties result in reduced overall abuse of the drug in the community?" We included opioid analgesics with abuse deterrent properties (hydrocodone, morphine, oxycodone) with results restricted to the metasearch term "delayed onset," English language, use in humans, and publication years 2009-2016. All articles that contained data evaluating misuse, abuse, overdose, addiction, and death were included. The results were categorized using the Bradford-Hill criteria. We included 44 reports: hydrocodone (n = 7), morphine (n = 5), or oxycodone (n = 32) with Food and Drug Administration-approved Categories 1, 2, or 3 abuse deterrent labeling. The data currently available support the Hill criteria of strength (effect size), consistency (reproducibility), temporality, plausibility, and coherence. There was insufficient or no information available for the criteria of biological gradient, experiment, and analogy. We also assessed confounding factors and bias, which indicated that both were present and substantial in magnitude. Our analysis found that only oxycodone extended release (ER) had information available to evaluate abuse deterrence in the community. In Australia, Canada, and the United States, reformulation of oxycodone ER was followed by marked reduction in measures of abuse. The precise extent of reduced abuse cannot be calculated because of heterogeneous data sets, but the reported reductions ranged from 10 to 90 percent depending on the measure and the duration of follow-up.

Space and the Third Offset Symposium - Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bahney, B.

The Third Offset Workshop explored the nature of the challenges and opportunities facing the United States as it is increasingly forced to integrate space into defense strategy as well as deterrence and strategic stability frameworks. Participants broadly agreed that Washington’s deep ties to allies and partners, as well as its history of leveraging an innovative U.S private sector, will be enduring competitive advantages against potential rivals into the foreseeable future. Yet panelists also highlighted key challenges from Russia and China’s rapid integration of space capabilities into conventional and nuclear warfighting, the pronounced growth in Chinese and Russian counterspace capabilities, andmore » tensions in the U.S.-Russia relationship.« less

Endogenous and costly institutional deterrence

Treesearch

David C. Kingsley; Thomas C. Brown

2014-01-01

Modern economies rely on central-authority institutions to regulate individual behaviour. Despite the importance of such institutions little is known about their formation within groups. In a public good experiment, groups selected the level of deterrence implemented by the institution, knowing that the administrative costs of the institution rose with the level of...

Effects of acoustic deterrents on foraging bats

Treesearch

Joshua B. Johnson; W. Mark Ford; Jane L. Rodrigue; John W. Edwards

2012-01-01

Significant bat mortality events associated with wind energy expansion, particularly in the Appalachians, have highlighted the need for development of possible mitigation practices to reduce or prevent strike mortality. Other than increasing turbine cut-in speed, acoustic deterrents probably hold the greatest promise for reducing bat mortality. However, acoustic...

Use of intermediaries in DWI deterrence. Volume 2, Phase 1 report : analysis of potential target clusters for DWI intermediary programs

DOT National Transportation Integrated Search

1983-04-01

This report summarizes the results of Phase I of the project, "Use of Intermediaries in DWI Deterrence." Data from secondary sources along with National Accident Samplimg System (NASS), Fatal Accident Reporting System (FARS) and National Institute on...

Deterrents to Women's Participation in Continuing Professional Development

ERIC Educational Resources Information Center

Chuang, Szu-Fang

2015-01-01

This study was designed to explore and define key factors that deter women from participating in continuing professional development (CPD) in the workplace. Four dimensions of deterrents that are caused by women's social roles, gender inequality and gender dimensions are discussed: family and time constraints, cost and work constraints, lack of…

Decision-making competence and attempted suicide

PubMed Central

Szanto, Katalin; Bruine de Bruin, Wändi; Parker, Andrew M; Hallquist, Michael N; Vanyukov, Polina M; Dombrovski, Alexandre Y

2015-01-01

Objective The propensity of people vulnerable to suicide to make poor life decisions is increasingly well documented. Do they display an extreme degree of decision biases? The present study used a behavioral decision approach to examine the susceptibility of low-lethality and high-lethality suicide attempters to common decision biases, which may ultimately obscure alternative solutions and deterrents to suicide in a crisis. Method We assessed older and middle-aged individuals who made high-lethality (medically serious; N=31) and low-lethality suicide attempts (N=29). Comparison groups included suicide ideators (N=30), non-suicidal depressed (N=53), and psychiatrically healthy participants (N=28). Attempters, ideators, and non-suicidal depressed participants had unipolar non-psychotic major depression. Decision biases included sunk cost (inability to abort an action for which costs are irrecoverable), framing (responding to superficial features of how a problem is presented), under/overconfidence (appropriateness of confidence in knowledge), and inconsistent risk perception. Data were collected between June of 2010 and February of 2014. Results Both high- and low-lethality attempters were more susceptible to framing effects, as compared to the other groups included in this study (p≤ 0.05, ηp2 =.06). In contrast, low-lethality attempters were more susceptible to sunk costs than both the comparison groups and high-lethality attempters (p≤ 0.01, ηp2 =.09). These group differences remained after accounting for age, global cognitive performance, and impulsive traits. Premorbid IQ partially explained group differences in framing effects. Conclusion Suicide attempters’ failure to resist framing may reflect their inability to consider a decision from an objective standpoint in a crisis. Low-lethality attempters’ failure to resist sunk-cost may reflect their tendency to confuse past and future costs of their behavior, lowering their threshold for acting on suicidal thoughts. PMID:26717535

Decision-making competence and attempted suicide.

PubMed

Szanto, Katalin; Bruine de Bruin, Wändi; Parker, Andrew M; Hallquist, Michael N; Vanyukov, Polina M; Dombrovski, Alexandre Y

2015-12-01

The propensity of people vulnerable to suicide to make poor life decisions is increasingly well documented. Do they display an extreme degree of decision biases? The present study used a behavioral-decision approach to examine the susceptibility of low-lethality and high-lethality suicide attempters to common decision biases that may ultimately obscure alternative solutions and deterrents to suicide in a crisis. We assessed older and middle-aged (42-97 years) individuals who made high-lethality (medically serious) (n = 31) and low-lethality suicide attempts (n = 29). Comparison groups included suicide ideators (n = 30), nonsuicidal depressed participants (n = 53), and psychiatrically healthy participants (n = 28). Attempters, ideators, and nonsuicidal depressed participants had nonpsychotic major depression (DSM-IV criteria). Decision biases included sunk cost (inability to abort an action for which costs are irrecoverable), framing (responding to superficial features of how a problem is presented), underconfidence/overconfidence (appropriateness of confidence in knowledge), and inconsistent risk perception. Data were collected between June 2010 and February 2014. Both high- and low-lethality attempters were more susceptible to framing effects as compared to the other groups included in this study (P ≤ .05, ηp2 = 0.06). In contrast, low-lethality attempters were more susceptible to sunk costs than both the comparison groups and high-lethality attempters (P ≤ .01, ηp2 = 0.09). These group differences remained after accounting for age, global cognitive performance, and impulsive traits. Premorbid IQ partially explained group differences in framing effects. Suicide attempters' failure to resist framing may reflect their inability to consider a decision from an objective standpoint in a crisis. Failure of low-lethality attempters to resist sunk cost may reflect their tendency to confuse past and future costs of their behavior, lowering their threshold for acting on suicidal thoughts. © Copyright 2015 Physicians Postgraduate Press, Inc.

Deterrent activity of plant lectins on cowpea weevil Callosobruchus maculatus (F.) oviposition.

PubMed

Sadeghi, Amin; Van Damme, Els J M; Peumans, Willy J; Smagghe, Guy

2006-09-01

A set of 14 plant lectins was screened in a binary choice bioassay for inhibitory activity on cowpea weevil Callosobruchus maculatus (F.) oviposition. Coating of chickpea seeds (Cicer arietinum L.) with a 0.05% (w/v) solution of plant lectins caused a significant reduction in egg laying. Control experiments with heat inactivated lectin and BSA indicated that the observed deterrent effects are specific and require carbohydrate-binding activity. However, no clear correlation could be established between deterrent activity and sugar-binding specificity/molecular structure of the lectins. Increasing the insect density reduced the inhibitory effect of the lectins confirming that female insects are capable of adjusting their oviposition rates as a function of host availability.

Callicarpenal and Intermedeol: Two Natural Arthropod Feeding Deterrent and Repellent Compounds Identified from the Southern Folk Remedy Plant, Callicarpa americana

USDA-ARS?s Scientific Manuscript database

In previous studies on the American beautyberry (Callicarpa americana), it was demonstrated that callicarpenal and intermedeol were responsible for the arthropod repellent and feeding deterrent activity of this folk remedy. Both compounds showed significant bite-deterring activity against Aedes aeg...

2015 Cross-Domain Deterrence Seminar Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juarez, A.

2016-01-11

Lawrence Livermore National Laboratory (LLNL) hosted the 2nd Annual Cross-Domain Deterrence Seminar on November 17th, 2015 in Livermore, CA. The seminar was sponsored by LLNL’s Center for Global Security Research (CGSR), National Security Office (NSO), and Global Security program. This summary covers the seminar’s panels and subsequent discussions.

Strategic Personality and the Effectiveness of Nuclear Deterrence: Deterring Iraq and Iran

DTIC Science & Technology

2001-09-01

ES-1 I. NUCLEAR DETERRENCE AND THREAT REDUCTION IN THE ERA OF THE “KOSOVO SYNDROME ...without the Kosovo Syndrome ? ................................... 106 Appendix A: The Strategic Personality Types...the United States from intervening in their future internal ethnic, religious, political, or regional disputes. The rise of this “Kosovo Syndrome

American Naval Policy, Strategy, Plans and Operations in the Second Decade of the Twenty first Century

DTIC Science & Technology

2017-01-01

13 Maritime safety ...deterrence, ballistic missile defense, deterrence of conventional crises and war (through naval readiness and engagement), maritime safety operations...confidence-building measure and to avoid unwanted crises.55 Maritime safety This an area that is primarily the domain of the world’s Coast Guards

Here to Help: Third Party Deterrence Against Insurgent Groups

DTIC Science & Technology

2015-05-22

that the new threat “of delinquent states and shadowy terrorist groups” was beyond the effects of deterrence.8 However, for those seeking an alternative...foreignpolicy.com/2014/05/08/portrait-of-the-army-as-a-work-in-progress. 28 Statistically , there is reason to favor joint training programs, with the aim

Feeding deterrence and inhibitory effects of bee balm (Monarda didyma) leaves on fall armyworm

USDA-ARS?s Scientific Manuscript database

The fall armyworm [Spodoptera frugiperda (J.E. Smith)] is a serious pest of many field and horticulture crops. Because of the many advantages for the use of plant-derived pesticides, we tested whether bee balm (Monarda didyma L.) leaves could have feeding deterrence on fall armyworm. When S. frugipe...

The Effect of Suspension as a Deterrent to Student Misconduct

ERIC Educational Resources Information Center

Jackson, Angela Coleman

2014-01-01

The purpose of this study was to examine the effect of suspension as a deterrent to student misconduct. A mixed methods approach using both qualitative (interviews of administrators and teachers) and quantitative (discipline records of identified sixth graders) were utilized. In this case study approach, one-on-one semi-structured interviews were…

Isolation and identification of mosquito (Aedes aegypti) biting deterrent fatty acids from male inflorescences of breadfruit (Artocarpus altilis (Parkinson)Fosberg)

USDA-ARS?s Scientific Manuscript database

Dried male inflorescences of breadfruit (Artocarpus altilis, Moraceae) are burned in communities throughout Oceania to repel flying insects, including mosquitoes. This study was conducted to identify chemicals responsible for mosquito deterrence. Various crude extracts were evaluated, and the most a...

An Application of the Social Support Deterioration Deterrence Model to Rescue Workers

ERIC Educational Resources Information Center

Prati, Gabriele; Pietrantoni, Luca

2010-01-01

This study examined the role of social support in promoting quality of life in the aftermath of critical incidents involvement. Participants were a sample of 586 Italian rescue workers. Structural equation modelling was used to test the social support deterioration deterrence model. Results showed that the impact of critical incident involvement…

The nuclear dilemma and the just war tradition

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Brien, W.V.; Langan, J.

This book presents papers on the ethical aspects of nuclear weapons. Topics considered include the concept of a ''just'' war, national defense, political aspects, religion and politics, the failure of deterrence, conventional warfare, nuclear deterrence and democratic politics, the future of the nuclear debate, non-proliferation policy, arms control, national security, and government policies.

Risk based In Vitro Performance Assessment of Extended Release Abuse Deterrent Formulations

PubMed Central

Xu, Xiaoming; Gupta, Abhay; Al-Ghabeish, Manar; Calderon, Silvia N.; Khan, Mansoor A.

2016-01-01

High strength extended release opioid products, which are indispensable tools in the management of pain, are associated with serious risks of unintentional and potentially fatal overdose, as well as of misuse and abuse that might lead to addiction. The issue of drug abuse becomes increasingly prominent when the dosage forms can be readily manipulated to release a high amount of opioid or to extract the drug in certain products or solvents. One approach to deter opioid drug abuse is by providing novel abuse deterrent formulations (ADF), with properties that may be viewed as barriers to abuse of the product. However, unlike regular extended release formulations, assessment of ADF technologies are challenging, in part due to the great variety of formulation designs available to achieve deterrence of abuse by oral, parenteral, nasal and respiratory routes. With limited prior history or literature information, and lack of compendial standards, evaluation and regulatory approval of these novel drug products become increasingly difficult. The present article describes a risk-based standardized in-vitro approach that can be utilized in general evaluation of abuse deterrent features for all ADF products. PMID:26784976

Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data.

PubMed

Muthivhi, T N; Olmsted, M G; Park, H; Sha, M; Raju, V; Mokoena, T; Bloch, E M; Murphy, E L; Reddy, R

2015-08-01

South Africa has a markedly skewed representation where the majority of blood (62%) is presently collected from an ethnically White minority. This study seeks to identify culturally specific factors affecting motivation of donors in South Africa. We performed a qualitative study to evaluate motivators and deterrents to blood donation among Black South Africans. A total of 13 focus groups, comprising a total of 97 Black South Africans, stratified by age and geographic location were conducted. Transcripts of the interviews were analysed using a coding framework by Bednall & Bove. Participants made 463 unique comments about motivators focusing primarily on promotional communications (28%), incentives (20%) and prosocial motivation (16%). Participants made 376 comments about deterrents which focused primarily on fear (41%), negative attitudes (14%) and lack of knowledge (10%). Although prosocial motivation (altruism) was the most frequently mentioned individual motivator, promotional communication elicited more overall comments by participants. As reported by many authors, fear and lack of awareness were strong deterrents, but scepticism engendered by perceived racial discrimination in blood collection were unique to the South African environment. © 2015 British Blood Transfusion Society.

In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice

PubMed Central

Yoon, Kyong Sup; Ketzis, Jennifer K.; Andrewes, Samuel W.; Wu, Christopher S.; Honraet, Kris; Staljanssens, Dorien; Rossel, Bart; Marshall Clark, J.

2015-01-01

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated with either of the test formulations, which led to significantly higher ovipositional avoidance when compared with female lice on control hair tufts. Additionally, both formulations were determined to be competent infestation deterrents in a competitive avoidance test in the presence of a known attractant (head louse feces extract). In in vivo assessments using a previously validated poultry model, Elimax shampoo was determined to be an efficacious deterrent against poultry chewing lice within Menopon spp. and Menacanthus spp. PMID:26336209

Thinking Globally about U.S. Extended Deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, Brad; Santoro, David; Volpe, Tristan

In contrast to the Cold War bilateral global competition between the United States and the Soviet Union, the modern nuclear age features a more complex, multiplayer arena on the regional scale. With the exception of the U.S. and Russia, most major powers retain relatively small nuclear arsenals or technical hedge capabilities. The U.S., with strong interests and security partnerships in Europe, Northeast Asia, and the Middle East, must navigate through long-standing rivalries and active conflicts while attempting to divine the intentions of less experienced nuclear decision makers in charge of weak domestic institutions. As a result, analysts and policymakers mustmore » think globally about U.S. extended deterrence. How have the requirements of extended deterrence and assurance changed? Are there important threads that connect each region? What should the U.S. do differently? To explore these questions, Lawrence Livermore National Laboratory’s Center for Global Security Research, in partnership with the Carnegie Endowment for International Peace and the Pacific Forum CSIS, held a workshop on “Thinking Globally about U.S. Extended Deterrence” in Washington, DC on November 2, 2015. The workshop brought together approximately 40 U.S. and foreign deterrence specialists and government officials, all attending in their private capacities. The participants joined a day of not-for-attribution discussions on the changing deterrence and assurance requirements, the threads that connect the regions, and U.S. strategy to deal with emerging challenges. The following is a summary of key takeaways.« less

Administrative license suspension: Does length of suspension matter?

PubMed

Fell, James C; Scherer, Michael

2017-08-18

Administrative license revocation (ALR) laws, which provide that the license of a driver with a blood alcohol concentration at or over the illegal limit is subject to an immediate suspension by the state department of motor vehicles, are an example of a traffic law in which the sanction rapidly follows the offense. The power of ALR laws has been attributed to how swiftly the sanction is applied, but does the length of suspension matter? Our objectives were to (a) determine the relationship of the ALR suspension length to the prevalence of drinking drivers relative to sober drivers in fatal crashes and (b) estimate the extent to which the relationship is associated to the general deterrent effect compared to the specific deterrent effect of the law. Data comparing the impact of ALR law implementation and ALR law suspension periods were analyzed using structural equation modeling techniques on the ratio of drinking drivers to nondrinking drivers in fatal crashes from the Fatality Analysis Reporting System (FARS). States with an ALR law with a short suspension period (1-30 days) had a significantly lower drinking driver ratio than states with no ALR law. States with a suspension period of 91-180 days had significantly lower ratios than states with shorter suspension periods, while the three states with suspension lengths of 181 days or longer had significantly lower ratios than states with shorter suspension periods. The implementation of any ALR law was associated with a 13.1% decrease in the drinking/nondrinking driver fatal crash ratio but only a 1.8% decrease in the intoxicated/nonintoxicated fatal crash ratio. The ALR laws and suspension lengths had a significant general deterrent effect, but no specific deterrent effect. States might want to keep (or adopt) ALR laws for their general deterrent effects and pursue alternatives for specific deterrent effects. States with short ALR suspension periods should consider lengthening them to 91 days or longer.

Aedes aegypti (Diptera: culicidae) biting deterrence: structure-activity relationship of saturated and unsaturated fatty acids

USDA-ARS?s Scientific Manuscript database

In this study we systematically evaluated for the first time the biting deterrent effects of a series of saturated and unsaturated fatty acids against Aedes aegypti [yellow fever mosquito (Diptera: Culicidae)] using the K & D bioassay system (Klun et al 2005). The saturated fatty acids (C6:0 to C16...

Identification of the mosquito biting deterrent constituents from the Indian folk remedy plant Jatropha curcas

USDA-ARS?s Scientific Manuscript database

An investigation of the Indian folk remedy plant, Jatropha curcas, was performed to specifically identify the constituents responsible for the mosquito biting deterrent activity of the oil as a whole. Jatropha curcas seed oil is burned in oil lamps in India and part of Africa to repel biting insect...

The International Politics of Peace Education: The Conflict between Deterrence and Disarmament.

ERIC Educational Resources Information Center

Willers, Jack Conrad

The main impetus for peace education is the arms race, which places peace education in the conflict between conservatives advocating increased nuclear deterrence and liberals supporting nuclear disarmament. In the United States, education for peace is still in its infancy. Other developed nations, such as the Scandinavian countries and to a lesser…

The Prospects of Employing Semiochemical and Visual Deterrents in Protecting Trees from Bark Beetles

Treesearch

B.L. Strom; L.M. Roton; J.L. Hayes; R.A. Goyer

1996-01-01

Tree protection tactics based on semiochemicals are being investigated by many forest scientists but their consistent effectiveness remains a concern. One approach toward increasing the efficacy of such treatments is to combine semiochemically-based tactics with deterrents that disrupt other cues necessary for host finding and colonization. In this study we...

Bioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianum

USDA-ARS?s Scientific Manuscript database

An ethanol extract from Veratrum lobelianum Bernh. rhizomes was evaluated for biting deterrent and larvicidal activity against Aedes aegypti. V. lobelianum extract showed larvicidal activity with LC50 values of 11.79 ppm and 89.9 ppm against 1st and 4th instar larvae, respectively, at 24 h post-trea...

JPRS Report, China

DTIC Science & Technology

1989-11-17

study of soil physical properties. At present, we have established field experimental plots in the loessial plain of the lower Yellow River, provided... effect on the military strength of countries all over the world. Under present conditions, science, technology, and economics are making unprec... effect deterrence, but are also producing profound changes in the methods of deterrence. Looking at the strategic situation worldwide, scientific

Rationality, Culture and Deterrence

DTIC Science & Technology

2013-09-01

Postgraduate School Center on Contemporary Conflict is the research wing of the Department of National Security Affairs ( NSA ) and specializes in the...and neuroscience . None of these approaches, either alone or in combination, offers a perfect framework for predicting the outcomes of deterrence...constructivism, approaches based on domestic and bureaucratic politics, and behavioral approaches drawn from findings in psychology and neuroscience

Strengthening Deterrence for 21st Century Strategic Conflicts and Competition: Accelerating Adaptation and Integration - Annotated Bibliography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, B.; Durkalec, J. J.

This was the fourth in a series of annual events convened at Livermore to exploring the emerging place of the “new domains” in U.S. deterrence strategies. The purposes of the series are to facilitate the emergence of a community of interest that cuts across the policy, military, and technical communities and to inform laboratory strategic planning. U.S. allies have also been drawn into the conversation, as U.S. deterrence strategies are in part about their protection. Discussion in these workshops is on a not-for-attribution basis. It is also makes no use of classified information. On this occasion, there were nearly 100more » participants from a dozen countries.« less

Moral and morale benefits of the Strategic Defense Initiative. Student report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poston, J.R.

1986-04-01

This writer finds strategic defense a moral advance over the present nuclear deterrence policy as well as a probable boost to national and military morale because of the broad-based popular support attendant to the inherent moral suasion. Popular support is nearly inevitable because of the moral superiority of strategic defense over nuclear retaliation, as well as the sheer compulsion of common sense about a protective defense. Criticism of the SDI abounds, but not without adequate answers from proponents. One of the best morale-building supports for those experiencing mixed moral feelings about nuclear deterrence is that strategic defense avoids or pointsmore » to a way out of the moral problems facing nuclear deterrence and its grim companion--nuclear retaliation.« less

Gender and stereotypes in motivation to study computer programming for careers in multimedia

NASA Astrophysics Data System (ADS)

Doubé, Wendy; Lang, Catherine

2012-03-01

A multimedia university programme with relatively equal numbers of male and female students in elective programming subjects provided a rare opportunity to investigate female motivation to study and pursue computer programming in a career. The MSLQ was used to survey 85 participants. In common with research into deterrence of females from STEM domains, females displayed significantly lower self-efficacy and expectancy for success. In contrast to research into deterrence of females from STEM domains, both genders placed similar high values on computer programming and shared high extrinsic and intrinsic goal orientation. The authors propose that the stereotype associated with a creative multimedia career could attract female participation in computer programming whereas the stereotype associated with computer science could be a deterrent.

Reality and responsibility revisited: Stakeholder accountability in the effort to develop safer opioids.

PubMed

Passik, Steven D; Heit, Howard A; DeGeorge, Michael

This supplement is dedicated to an exploration of the science, potential utility, and the current state of abuse-deterrent formulations (ADF) of opioid analgesics. There are many stakeholders in the search for safer pain treatments in general, and safer opioid therapy in particular. Healthcare providers, patients, third-party payors, law enforcement and government regulators, the pharmaceutical industry, and the media all have a stake in seeing pain treated and addiction and overdose avoided. As it applies to ADFs, obviously not everyone has a stake in seeing that ADFs succeed commercially; but all stakeholders certainly have a responsibility to see that any potential advance, including ADFs, in protecting the public health is fairly and thoroughly evaluated. Particularly at a time of crisis. In this article, we revisit the framework used by Passik, Heit, and Kirsh (2006) to evaluate stakeholders' responsibilities with regard to both the opioid abuse and chronic pain epidemics. After evaluating the present status of aspirations delineated over a decade ago, we discuss the updated roles and responsibilities of each stakeholder, with emphasis on the role of ADFs as this technology was unavailable when the original manuscript was written.

Shattering the silence of violence against women.

PubMed

1998-01-01

The UN Development Fund for Women has selected 23 projects in 18 developing countries to be beneficiaries of a $1.2 million trust fund dedicated to the elimination of violence against women. While the projects offer a variety of approaches to preventing and eliminating the domestic violence suffered by a third of the women in developing countries, all involve awareness-raising and advocacy, capacity-building, literacy, training, action research, and prevention/deterrence activities. A project in the Philippines will train women migrant workers who have been victimized by abuse to produce videos about their experience in order to raise consciousness about the rights of women and of workers. A South African project, which will address sexual assaults of high school students that occur in dating relationships, will involve a prevalence survey, a pilot project, an expansion of the project and curriculum development, a play on date rape, crisis intervention counseling, production of a video and manual, a national conference, and publication of essays produced by students who participated in the program. The Trust Fund was proposed by Japan in response to the urgent call for action issued by the 1995 UN Fourth World Conference on Women and is funded by donations from governments and private sources.

Protocol: changes in rates of opioid overdose and poisoning events in an integrated health system following the introduction of a formulation of OxyContin® with abuse-deterrent properties.

PubMed

Janoff, Shannon L; Perrin, Nancy A; Coplan, Paul M; Chilcoat, Howard D; Campbell, Cynthia I; Green, Carla A

2016-05-14

Addiction, overdoses and deaths resulting from prescription opioids have increased dramatically over the last decade. In response, several manufacturers have developed formulations of opioids with abuse-deterrent properties. For many of these products, the Food and Drug Administration (FDA) recognized the formulation with labeling claims and mandated post-marketing studies to assess the abuse-deterrent effects. In response, we assess differences in rates of opioid-related overdoses and poisonings prior to and following the introduction of a formulation of OxyContin® with abuse-deterrent properties. To assess effects of this formulation, electronic medical record (EMR) data from Kaiser Permanente Northwest (KPNW) and Kaiser Permanente Northern California (KPNC) are linked to state death data and compared to chart audits. Overdose and poisoning events will be categorized by intentionality and number of agents involved, including illicit drugs and alcohol. Using 6-month intervals over a 10-year period, trends will be compared in rates of opioid-related overdoses and poisoning events associated with OxyContin® to rates of events associated with other oxycodone and opioid formulations. Qualitative interviews with patients and relatives of deceased patients will be conducted to capture circumstances surrounding events. This study assesses and tracks changes in opioid-related overdoses and poisoning events prior to and following the introduction of OxyContin® with abuse-deterrent properties. Public health significance is high because these medications are designed to reduce abuse-related behaviors that lead to important adverse outcomes, including overdoses and deaths.

Deterrents to Nurses' Participation in Continuing Professional Education as Perceived by Licensed Nurses in Oklahoma

ERIC Educational Resources Information Center

Fahnestock, Annetta Bethene

2012-01-01

Little is known about the deterrents to licensed nurses' participation in continuing professional education (CPE) in Oklahoma, the licensed nurses' preferred method for obtaining CPE, and the ways in which employers support participation in CPE. A random sample of 78 licensed nurses in Oklahoma completed a 20 item questionnaire and a 40 item…

PRISM

DTIC Science & Technology

2017-12-21

deterrence approach is capable of exer- cising deterrence with virtual, psychological , moral, and physical aspects in an integrated way, thus lever...Julie Ryan T H E F I F T H D O M A I N Integrating cyber and electronic warfare capabilities increases the commander’s situational awareness. (U.S...cyber organizations and the interagency; and integrating cyber requirements into operational planning and execution. It will take continued

U.S. Army Training in the Tactical Employment of Chemical Weapons: A flaw in Our Chemical Deterrence?

DTIC Science & Technology

1988-12-09

y horse drawn milltary 𔃾 transportation system A.3 Germany began to suffer reverses In Fance .wld on tlt . front, Hitler, who initially had been...September 1987. Rogers, Gen Bernard. Interview. "Chemical Deterrence is Imperative". _ National Guard, March 1985, p. 27-8. Segal, David. ’Soviet Union’s

French Nuclear Strategy in an Age of Terrorism

DTIC Science & Technology

2006-12-01

PAGES 115 14. SUBJECT TERMS French Nuclear Strategy, Deterrence, Nuclear Doctrine, France , European Nuclear Deterrence, Franco-American Relations...Certain Idea of France (Princeton, NJ: Princeton University Press, 1993); Wilfrid L Kohl, French Nuclear Diplomacy (Princeton, NJ: Princeton University...nuclear program. 1. A Nuclear France : Inception of the force de frappe The French nuclear program started during the Fourth Republic, immediately

A U.S. Minimum Nuclear Deterrence Strategy: By Design or Default It’s about the Policy Options

DTIC Science & Technology

2012-06-01

then who are we to suggest actions that may upset the apple cart. Continued Retention of a Nuclear Deterrence Force. The ideas of M. K. Ghandi ...shaped India’s thinking about nuclear weapons. Ghandi espoused non-violence as a political strategy and his moral rejection of nuclear weapons laid the

Abuse-deterrent formulations: transitioning the pharmaceutical market to improve public health and safety

PubMed Central

Worthy, Stacey L.; Barnes, Michael C.; Tarbell, Benjamin

2015-01-01

This article evaluates abuse-deterrent formulations (ADFs) as a method to reduce prescription drug abuse while ensuring access to vital medications for individuals with legitimate need; assesses the pros and cons of ADFs and the current state of ADF adoption in the market; and develops policy recommendations to transition the market to ADFs. Although abuse-deterrent technology is still in its nascent stages, ADFs have been proven to reduce prescription drug abuse and its consequences, and even an incremental reduction in abuse can have a significant impact on the nation by reducing the costly social, physical, mental, and public health problems resulting from abuse. Federal ADF policy does not reflect the urgency of the prescription drug abuse epidemic and does not go far enough toward changing the status quo. Policies must be implemented to encourage innovation and a market shift toward ADFs by ensuring any generic medication that references a branded ADF demonstrates that it does not have abuse-deterrent properties inferior to the branded ADF product. Policies must also require federal prescription drug benefit plans to cover ADFs to ensure consumers have access to such medications. PMID:25922655

Age differences in understanding precedent-setting decisions and authorities' responses to violations of deontic rules.

PubMed

Klaczynski, Paul A

2011-05-01

To examine age trends in precedent-setting decisions and the effects of these decisions on perceptions of authorities, preadolescents and adolescents were presented with deontic rule infractions that occurred in the absence or presence of mitigating circumstances. In Study 1, in the absence of mitigating circumstances, adolescents recommended punishing rule violations more than preadolescents; when mitigating circumstances were present, adolescents recommended punishing infractions less than preadolescents. In Study 2, before and after receiving information that authorities had punished or permitted rule violations, participants indicated their beliefs in authority legitimacy, rule strength, and rule deterrence value. In the absence of mitigating circumstances, beliefs strengthened when infractions were punished and beliefs weakened when infractions were permitted. When mitigating circumstances were present and authorities punished violations, preadolescents' legitimacy and deterrence beliefs strengthened. Adolescents' deterrence beliefs strengthened, but their beliefs in authority legitimacy weakened. When justifiable infractions were permitted, preadolescents' legitimacy and deterrence beliefs weakened, whereas adolescents' beliefs strengthened. Discussion focuses on age differences in legitimacy beliefs and understanding the consequences of setting precedents and on the relevance of the findings to theories of deontic reasoning, moral judgments, and epistemological development. Copyright © 2010 Elsevier Inc. All rights reserved.

In Vitro and In Vivo Evaluation of Infestation Deterrents Against Lice.

PubMed

Yoon, Kyong Sup; Ketzis, Jennifer K; Andrewes, Samuel W; Wu, Christopher S; Honraet, Kris; Staljanssens, Dorien; Rossel, Bart; Marshall Clark, J

2015-09-01

The human head louse is a cosmopolitan ectoparasite and frequently infests many people, particularly school-age children. Due to widespread pyrethroid resistance and the lack of efficient resistance management, there has been a considerable interest in the protection of uninfested people and prevention of reinfestation by disrupting lice transfer. In this study, two nonclinical model systems (in vitro and in vivo) were used to determine the efficacy of the infestation deterrents, Elimax lotion and Elimax shampoo, against human head lice or poultry chewing lice, respectively. With in vitro assessments, female head lice exhibited significantly higher avoidance responses to hair tufts treated with either of the test formulations, which led to significantly higher ovipositional avoidance when compared with female lice on control hair tufts. Additionally, both formulations were determined to be competent infestation deterrents in a competitive avoidance test in the presence of a known attractant (head louse feces extract). In in vivo assessments using a previously validated poultry model, Elimax shampoo was determined to be an efficacious deterrent against poultry chewing lice within Menopon spp. and Menacanthus spp. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America.

Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data

PubMed Central

Muthivhi, T. N.; Olmsted, M. G.; Park, H.; Sha, M.; Raju, V.; Mokoena, T.; Bloch, E. M.; Murphy, E. L.; Reddy, R.

2015-01-01

SUMMARY Background and Objectives South Africa has a markedly skewed representation where the majority of blood (62%) is presently collected from an ethnically White minority. This study seeks to identify culturally specific factors affecting motivation of donors in South Africa. Materials and Methods We performed a qualitative study to evaluate motivators and deterrents to blood donation among Black South Africans. A total of 13 focus groups, comprising a total of 97 Black South Africans, stratified by age and geographic location were conducted. Transcripts of the interviews were analysed using a coding framework by Bednall & Bove. Results Participants made 463 unique comments about motivators focusing primarily on promotional communications (28%), incentives (20%) and prosocial motivation (16%). Participants made 376 comments about deterrents which focused primarily on fear (41%), negative attitudes (14%) and lack of knowledge (10%). Conclusion Although prosocial motivation (altruism) was the most frequently mentioned individual motivator, promotional communication elicited more overall comments by participants. As reported by many authors, fear and lack of awareness were strong deterrents, but scepticism engendered by perceived racial discrimination in blood collection were unique to the South African environment. PMID:26104809

Wave energy analysis based on simulation wave data in the China Sea

NASA Astrophysics Data System (ADS)

Gao, Zhan-sheng; Qian, Yu-hao; Sui, Yu-wei; Chen, Xuan; Zhang, Da

2018-05-01

In the current world, where human beings are severely plagued by environmental problems and energy crisis, the full and reasonable utilization of marine new energy resources will contribute to alleviating the energy crisis, contributing to global energy-saving, emission reduction and environmental protection, thus to promote sustainable development. In this study, we firstly simulated a 10-year (1991-2000) 6-hourly wave data of the China Sea, by using the Simulating WAves Nearshore (SWAN) wave model nested with WAVEWATCH-III (WW3) wave model forced with Cross-Calibrated, Multi-Platform (CCMP) wind data. Considering the value size and stability of the wave energy density, we analyzed the overall characteristics of the China Sea wave energy with using the simulation wave data. Results show that: (1) The wave energy density in January and October is distinctly higher than that in April and July. The large center of annual average Wave energy density is located in the north of the South China Sea (of about 12-16 kW/m). (2) Synthetically considering the value size and stability of the wave energy density and stability, the energy-rich area is found to be located in the north region of the South China Sea.

[HYPERTENSIVE CRISIS: MODERN VIEW OF THE PROBLEM AND OPTIMIZATION OF DIAGNOSTIC AND THERAPEUTIC MODALITIES].

PubMed

Kryukov, E V; Potekhin, N P; Fursov, A N; Chernetsov, V A; Chernov, S A; Zakharova, E G

2016-01-01

The data collected by Burdenko Military Hospital indicate that in the 1980s hypertensive crisis (HC) occurred in roughly 30% of the patients with AH. This value fell down to 16% by 2012, with a rise in the number of uncomplicated crises from 46 to 62%. Analysis of the causes behind these changes showed that half of the patients simply experienced an elevated arterial pressure with minimal clinical symptoms. The decrease in the number of complicated cases from 54 to 39% is doubtful bearing in mind that ICD-10 gives the status of nosological entities to complications of hypertensive crisis (stroke, myocardial infarction, etc.) but not to the HC syndrome proper requiring urgent hospitalization; due to this hypertensive crisis itself tends to be disregarded and not included in statistics. HC with acute clinically significant lesions of target organs requires intensive care or resuscitation using infusion of vasodilators and loop diuretics to stabilize arterial pressure. In case of uncomplicted HC and aggravation of hypertensive disease, the medications of choice are oral short-acting ACE inhibitors and imidazoline receptor agonists.

The effect of the global financial crisis on preventable hospitalizations among the homeless in New York State.

PubMed

White, Brandi; Ellis, Charles; Jones, Walter; Moran, William; Simpson, Kit

2018-04-01

Objective Periods of economic instability may increase preventable hospitalizations because of increased barriers to accessing primary care. For underserved populations such as the homeless, these barriers may be more pronounced due to limited resources in the health care safety net. This study examined the impact of the global financial crisis of 2007-2008 on access to care for the homeless in New York State. Methods Hospitalizations for ambulatory care sensitive conditions (ACSCs) were used as a proxy measure for primary care access. Admissions for ACSCs were identified in the New York State Inpatient Database from 2006 to 2012. Hospitalization rates for ACSCs were calculated for the homeless and nonhomeless. Multivariable linear regression was used to investigate the impact of the financial crisis on hospitalization rates for ACSCs. Results The findings indicate that during the financial crisis, homeless adults had significantly higher preventable hospitalizations than nonhomeless adults, and the uninsured homeless had significantly higher preventable hospitalizations when compared to other homeless subgroups. After the financial crisis, preventable hospitalizations for the homeless stabilized but remained at higher rates than those for the nonhomeless. Conclusions These findings are important to developing health policies designed to provide effective care for underserved population such as the homeless.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beck, James B.

Welcome to the February newsletter. Recent highlights include progress on the nuclear deal with Iran, the continued challenges with North Korea, the developing situation in Ukraine and Georgia, and issues related to the Unites States Nuclear Deterrent. In this newsletter, some key messages from the recent Nuclear Deterrent summit, which is annually held in Washington, DC, asre also included. The NSO recently hosted a workshop organized with the Center for International Security and Cooperation (CISAC) at Stanford University on how other States view nuclear weapons and deterrence. Participants included Dr. Bradley Roberts, Gen. (Ret.) Robert Kehler, Bridge Colby, Dr. Robertmore » Gromoll, and other experts. If you would like to have a more in-depth discussion on this or any related topics, please contact Sylvia Martinez at 667-6120 to set up some time.« less

Forecasting of magnitude and duration of currency crises based on the analysis of distortions of fractal scaling in exchange rate fluctuations

NASA Astrophysics Data System (ADS)

Uritskaya, Olga Y.

2005-05-01

Results of fractal stability analysis of daily exchange rate fluctuations of more than 30 floating currencies for a 10-year period are presented. It is shown for the first time that small- and large-scale dynamical instabilities of national monetary systems correlate with deviations of the detrended fluctuation analysis (DFA) exponent from the value 1.5 predicted by the efficient market hypothesis. The observed dependence is used for classification of long-term stability of floating exchange rates as well as for revealing various forms of distortion of stable currency dynamics prior to large-scale crises. A normal range of DFA exponents consistent with crisis-free long-term exchange rate fluctuations is determined, and several typical scenarios of unstable currency dynamics with DFA exponents fluctuating beyond the normal range are identified. It is shown that monetary crashes are usually preceded by prolonged periods of abnormal (decreased or increased) DFA exponent, with the after-crash exponent tending to the value 1.5 indicating a more reliable exchange rate dynamics. Statistically significant regression relations (R=0.99, p<0.01) between duration and magnitude of currency crises and the degree of distortion of monofractal patterns of exchange rate dynamics are found. It is demonstrated that the parameters of these relations characterizing small- and large-scale crises are nearly equal, which implies a common instability mechanism underlying these events. The obtained dependences have been used as a basic ingredient of a forecasting technique which provided correct in-sample predictions of monetary crisis magnitude and duration over various time scales. The developed technique can be recommended for real-time monitoring of dynamical stability of floating exchange rate systems and creating advanced early-warning-system models for currency crisis prevention.

Bomber Deterrence Missions: Criteria To Evaluate Mission Effectiveness

DTIC Science & Technology

2016-02-16

International Relations from Brigham Young University and a Master of Science degree in Aviation Safety Management from the University of Central...AIR WAR COLLEGE AIR UNIVERSITY BOMBER DETERRENCE MISSIONS: CRITERIA TO EVALUATE MISSION EFFECTIVENESS by Bradley L. Cochran, Col, USAF A...paper are those of the author and do not reflect the official policy or position of the US government, the Department of Defense, or Air University

"Deterrability" among Gang and Nongang Juvenile Offenders: Are Gang Members More (or Less) Deterrable than Other Juvenile Offenders?

ERIC Educational Resources Information Center

Maxson, Cheryl L.; Matsuda, Kristy N.; Hennigan, Karen

2011-01-01

This study investigates the effect of the threat of legal sanctions on intentions to commit three types of offenses with a representative sample of 744 officially adjudicated youth with varying histories of offenses and gang involvement. In a departure from previous research, the authors find small severity effects for property crimes that are not…

Conflict with China: Prospects, Consequences, and Strategies for Deterrence

DTIC Science & Technology

2011-01-01

Burma / Myanmar . Above and beyond the dangers posed by a clash between the world’s two most populous countries, the presence of nuclear weapons on...Reconnaissance CBRNE Chemical, Biological, Radiological, Nuclear , High-Yield Explosives DMZ Demilitarized Zone DPRK Democratic People’s Republic of Korea EEZ...most concern to the United States. 2 Conflict with China: Prospects, Consequences, and Strategies for Deterrence Occasions for Conflict North Korea

Airman Scholar Journal. Volume 19, Spring 2013

DTIC Science & Technology

2013-01-01

of technological prowess and a symbol of ideological victory over communism . The Apollo program, which Stephen Johnson has called the United States...CO,80840 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11 ...Space Deterrence in a Labrynthine World Zachary Crippen and Andrew Hilton Topical Focus: Proliferation and Deterrence 11 Racism: A Stumbling Block to

Cyberdeterrence and Cyberwar

DTIC Science & Technology

2009-01-01

introduce subtle but vehicle-damaging changes to the chemical mix in the gasoline. Battle damage prediction is critical in establishing deterrence at all...the emotional resonance of the sort engen - dered by bloody terrorist attacks. If the target system is private (which it would practically have to be...secondary deterrence are the successful dissuasion of Nazi Germany and, half a century later, Saddam’s Iraq from using chemical weapons. Strategic

Minimum Nuclear Deterrence Research

DTIC Science & Technology

2003-05-15

well as by additional experts interviewed in Paris (November 2002). One expert at the French MoD stressed the psychological importance of the 1940...continued to stress France’s commitment to "contributing to European security" specifically through the existence of its nuclear deterrent.43...Mondiale (Thesis, Paris, Librairie Générale de Droit et de Jurisprudence, 1966, p. 441) as cited in David Cumin , L’Arme

Deterrence in Cyberspace

DTIC Science & Technology

2012-06-13

sea craft, and affect food or water supplies are strategic and the target of a policy statement on cyber deterrence. Cyber-isolation The third...mechanical damage, but the uranium that was enriched was done so incorrectly and was contaminated to a point it would have to be re-processed.8...Insurgency, and Peacekeeping, (New York: Stackpole, 1971). 38 in Malaysia , or at least it provides a readily available conduit to communication

Biting deterrence and insecticidal activity of hydrazide–hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles against Aedes aegypti

USDA-ARS?s Scientific Manuscript database

BACKGROUND: Hydrazones are important compounds for drug design and they have also good insecticidal activity. In this study, A series of hydrazide–hydrazones (1-10) and 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles (11-20) were investigated for their biting deterrent and insecticidal act...

NATOs Deterrence Strategy is Failing. The Enhanced Forward Presence: Delusion or Renewal

DTIC Science & Technology

2018-04-20

can credibly deter Russia. NATO, Enhanced Forward Presence, Deterrence, Multi -Domain Battle, Russia, Baltics Unclassified Unclassified Unclassified...Strategy. The contents of this paper reflect my own personal views and are not necessarily endorsed by the Joint Forces Staff College or the Department... multi -domain capabilities . . . [and] control information,”5 but in response, NATO has struggled to convincingly adjust to this changing character

The nuclear arms debate: Ethical and political implications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johansen, R.C.

1984-01-01

This book contains the following seven papers: Moral Aspects of the Nuclear Arms Debate: The Contribution of the U.S. Catholic Bishops; The Strategic and Arms Control Implications of the Bishop's Pastoral Letter; Applying Just-War Doctrine to Nuclear Deterrence; Nuclearism in Western Culture; Mutal Assured Destruction: A Stable Nuclear Deterrent; The Prospect for a Freeze on Nuclear Weapons; and The Soviet Union and Arms Control.

France: Nukes Stuck between NATO and EU

DTIC Science & Technology

2013-03-01

answer to the original question of whether or not Italy would want Paris providing regional deterrence is “No.” Italy would rather eradicate nuclear...financial affairs, defense, and, specifically, it has signified that Paris would offer regional nuclear deterrence for Europe. On the one hand, such...wanted to play a decisive role within European politics, financial affairs, defense, and, specifically, it has signified that Paris would offer

Predicting DUI decisions in different legal environments: investigating deterrence with a conjoint experiment.

PubMed

Yao, Jie; Johnson, Mark B; Beck, Kenneth H

2014-01-01

Driving under the influence (DUI) enforcement practices and sanctions contribute differentially to the certainty, swiftness, and severity of punishment, which are the key components of general deterrence theory. This study used a conjoint experiment to understand the decision-making process of potential DUI offenders and tested how variation in enforcement and legal punishment affects drinking and driving decisions. It sought to verify and quantify the unique deterrent effects of certainty, severity, and swiftness and to predict the rates of drinking and driving in different legal environments. One hundred twenty-one college seniors and graduate students at the University of Maryland participated in the Web-based conjoint experiment. They were randomly assigned to 4 blocks, each of which included 9 hypothetical scenarios composed of different levels of DUI enforcement and penalties. Respondents were asked to state their likelihood of drinking and driving under each scenario, as well as their estimated chance of being caught by the police for DUI. Intensified enforcement, harsh jail penalty, and immediate long license suspension were found to be the strongest deterrents to drinking and driving. Alternative ways to get home were also important in reducing people's willingness to drive. These factors accounted for most of the attribute effect on the DUI decision, whereas delayed punishment due to judicial processing, fine penalty, and legal blood alcohol concentration (BAC) limit had negligible effects. For the personal characteristics, college seniors and those who had previously driven after drinking were more likely to choose to drink and drive, whereas those who expect a jail penalty for a DUI offense were less likely to drive. Our research confirmed and quantified certainty of punishment as the greatest deterrent to DUI, but it also indicated the equally important effect of a severe jail penalty. It provides evidence on the feasibility of using a conjoint experiment in future studies to understand the general driver population and, with the help of a simulation tool, to predict DUI decisions in different legal environments. Such predictions can be used to better inform policy decisions on developing targeted general deterrence programs in different communities.

Pakistan’s Capital Crisis: Implications for U.S. Policy

DTIC Science & Technology

2008-11-07

problems, with the support of his chief economic advisor, Shaukat Tarin. On September 19, 2008, acting finance minister Naveed Qamar released new economic...Finance Minister Qamar said that the economic stabilization package would create jobs and promote agriculture and manufacturing, and reduce poverty

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

PubMed Central

Counter, C M; Avilion, A A; LeFeuvre, C E; Stewart, N G; Greider, C W; Harley, C B; Bacchetti, S

1992-01-01

Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and protect their ends from recombination, we have measured telomere length, telomerase activity and chromosome rearrangements in human cells before and after transformation with SV40 or Ad5. In all mortal populations, telomeres shortened by approximately 65 bp/generation during the lifespan of the cultures. When transformed cells reached crisis, the length of the telomeric TTAGGG repeats was only approximately 1.5 kbp and many dicentric chromosomes were observed. In immortal cells, telomere length and frequency of dicentric chromosomes stabilized after crisis. Telomerase activity was not detectable in control or extended lifespan populations but was present in immortal populations. These results suggest that chromosomes with short (TTAGGG)n tracts are recombinogenic, critically shortened telomeres may be incompatible with cell proliferation and stabilization of telomere length by telomerase may be required for immortalization. Images PMID:1582420

Conceptions of politics, morality, and war in the nuclear policy debates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ware, L.C.

1993-01-01

During the resurgent nuclear debates from the mid-1970s to the mid-1980s, analysts sharply disagreed about the appropriate means and ends of strategy. Deterrence dominance strategists argued that America required a countervailing capacity to sustain a viable deterrent posture and to contain Soviet adventurism. Proponents of pure deterrence claimed that the risks endemic to mutual vulnerability would suffice to moderate the superpower rivalry. Advocates of denuclearization charged that reliance on nuclear weaponry posed the greatest danger to human well-being and called for diplomatic measures to establish a disarmament regime. While scholars have systemically explored the strategic and technological components of themore » controversy, few studies have examined the political theoretic dimensions. Through a textual exegesis of the writings of key participants, this work seeks to demonstrate that contending conceptions of politics and morality inform dissension about the viability of coercive power in the nuclear age. Justifications of deterrence dominance proposals generally conflate political and ethical considerations through variants of Hobbesian skepticism or liberal just war interventionism. Such arguments perceive the state as the locus of societal values and sovereignty as sanctioning extensive activities in the global system. Pure deterrence notions posit an irreconcilable tension between politics and morality that corresponds with a tragic vision: war may be a necessary element of sociality, but it seldom has truly creative consequences. From this perspective, the state is a morally ambiguous agent that can preserve and endanger societal well-being. Finally, associated with the denuclearization school is a conviction that progressive social movements can conform politics to essential ethical precepts by minimizing the role of coercive power. In this view, the state and its claim to sovereignty are primary sources of the war system, hence must be radically altered.« less

The deterrent forces of the Commonwealth of Independent States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kortunov, S.

The rapid changes that are occurring in Europe and in the world at large create qualitatively new military and political realities and will force nuclear powers to make major adjustments in their foreign policy and military-technological thinking. The new situation will certainly lead to changes in both the nuclear doctrines of those countries and their approaches to nuclear forces - both strategic and tactical - as will be needed to ensure national security. This applies fully to the Commonwealth of Independent States (the former USSR), whose nuclear doctrine, like that of the North Atlantic Treaty Organization (NATO), is now beingmore » overhauled. It is well known that the former Soviet Union in its public declarations, including those made at the highest political level, has been strongly critical of the doctrine of deterrence. An unbiased historical analysis of the postwar period also demonstrates that military competition between the Soviet Union and the United States in the nuclear field followed the action-reaction logic, the constraining factors being primarily financial and technological rather than moral. Parity was initially interpreted as numerical equality in strategic nuclear arms and later as rough equality in operational nuclear capabilities. Another confirmation that the Soviet Union had based its policy precisely on the doctrine of deterrence is the Antiballistic Missile (ABM) Treaty, which limits the antiballistic missile systems of the two sides to purely symbolic numbers of ABMs and effectively exposes the former Soviet Union and the United States to a retaliatory strike. Nuclear deterrence is a modus vivendi of the world we live in, and it will stay that way until nations devise a fundamentally new system of maintaining international security. The problem is that the nuclear powers have more than enough nuclear weapons to make deterrence work effectively.« less

Off the street and into “the cut”: Deterrence and displacement in NYC's quality of life marijuana policing

PubMed Central

Elliott, Luther; Golub, Andrew; Dunlap, Eloise

2011-01-01

This paper examines the accounts of NYC marijuana smokers about the information and values underlying decisions about where to smoke. We do so to assess the deterrent value of NYC's “quality of life” policing of marijuana in public view. Participants indicated a general awareness of escalated marijuana policing and its attendant risks and almost universally spoke of avoiding public use in high-traffic locations and in the city's cultural and commercial centres. Beyond that, however, the deterrent value of aggressive marijuana policing appears limited. Individuals without access to private space reported outdoor marijuana use as a normalized peer group activity that has increasingly been displaced to marginal and interstitial public spaces that were collectively referred to by participants as “the cut.” PMID:22001856

Strategies to reduce driving under the influence of alcohol.

PubMed

DeJong, W; Hingson, R

1998-01-01

The purpose of this review is to update research on the prevention of alcohol-related traffic deaths since the 1988 Surgeon General's Workshop on Drunk Driving. Four primary areas of research are reviewed here: (a) general deterrence policies, (b) alcohol control policies, (c) mass communications campaigns, including advertising restrictions, and (d) community traffic safety programs. Modern efforts to combat drunk driving in the United States began with specific deterrence strategies to punish convicted drunk drivers, and then evolved to include general deterrence strategies that were targeted to the population as a whole. Efforts next expanded to include the alcohol side of the problem, with measures installed to decrease underage drinking and excessive alcohol consumption. In the next several years, greater efforts are needed on all these fronts. Also needed, however, are programs that integrate drunk driving prevention with other traffic safety initiatives.

A Game Theoretic Model of Thermonuclear Cyberwar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soper, Braden C.

In this paper we propose a formal game theoretic model of thermonuclear cyberwar based on ideas found in [1] and [2]. Our intention is that such a game will act as a first step toward building more complete formal models of Cross-Domain Deterrence (CDD). We believe the proposed thermonuclear cyberwar game is an ideal place to start on such an endeavor because the game can be fashioned in a way that is closely related to the classical models of nuclear deterrence [4–6], but with obvious modifications that will help to elucidate the complexities introduced by a second domain. We startmore » with the classical bimatrix nuclear deterrence game based on the game of chicken, but introduce uncertainty via a left-of-launch cyber capability that one or both players may possess.« less

Resonances in a Chaotic Attractor Crisis of the Lorenz Flow

NASA Astrophysics Data System (ADS)

Tantet, Alexis; Lucarini, Valerio; Dijkstra, Henk A.

2018-02-01

Local bifurcations of stationary points and limit cycles have successfully been characterized in terms of the critical exponents of these solutions. Lyapunov exponents and their associated covariant Lyapunov vectors have been proposed as tools for supporting the understanding of critical transitions in chaotic dynamical systems. However, it is in general not clear how the statistical properties of dynamical systems change across a boundary crisis during which a chaotic attractor collides with a saddle. This behavior is investigated here for a boundary crisis in the Lorenz flow, for which neither the Lyapunov exponents nor the covariant Lyapunov vectors provide a criterion for the crisis. Instead, the convergence of the time evolution of probability densities to the invariant measure, governed by the semigroup of transfer operators, is expected to slow down at the approach of the crisis. Such convergence is described by the eigenvalues of the generator of this semigroup, which can be divided into two families, referred to as the stable and unstable Ruelle-Pollicott resonances, respectively. The former describes the convergence of densities to the attractor (or escape from a repeller) and is estimated from many short time series sampling the state space. The latter is responsible for the decay of correlations, or mixing, and can be estimated from a long times series, invoking ergodicity. It is found numerically for the Lorenz flow that the stable resonances do approach the imaginary axis during the crisis, as is indicative of the loss of global stability of the attractor. On the other hand, the unstable resonances, and a fortiori the decay of correlations, do not flag the proximity of the crisis, thus questioning the usual design of early warning indicators of boundary crises of chaotic attractors and the applicability of response theory close to such crises.

Resonances in a Chaotic Attractor Crisis of the Lorenz Flow

NASA Astrophysics Data System (ADS)

Tantet, Alexis; Lucarini, Valerio; Dijkstra, Henk A.

2017-12-01

Local bifurcations of stationary points and limit cycles have successfully been characterized in terms of the critical exponents of these solutions. Lyapunov exponents and their associated covariant Lyapunov vectors have been proposed as tools for supporting the understanding of critical transitions in chaotic dynamical systems. However, it is in general not clear how the statistical properties of dynamical systems change across a boundary crisis during which a chaotic attractor collides with a saddle. This behavior is investigated here for a boundary crisis in the Lorenz flow, for which neither the Lyapunov exponents nor the covariant Lyapunov vectors provide a criterion for the crisis. Instead, the convergence of the time evolution of probability densities to the invariant measure, governed by the semigroup of transfer operators, is expected to slow down at the approach of the crisis. Such convergence is described by the eigenvalues of the generator of this semigroup, which can be divided into two families, referred to as the stable and unstable Ruelle-Pollicott resonances, respectively. The former describes the convergence of densities to the attractor (or escape from a repeller) and is estimated from many short time series sampling the state space. The latter is responsible for the decay of correlations, or mixing, and can be estimated from a long times series, invoking ergodicity. It is found numerically for the Lorenz flow that the stable resonances do approach the imaginary axis during the crisis, as is indicative of the loss of global stability of the attractor. On the other hand, the unstable resonances, and a fortiori the decay of correlations, do not flag the proximity of the crisis, thus questioning the usual design of early warning indicators of boundary crises of chaotic attractors and the applicability of response theory close to such crises.

The Time Is Now: Educating Citizens for a High-Tech World.

ERIC Educational Resources Information Center

Daly, William T.

1985-01-01

The "crisis" in American education is seen as a major opportunity for American educators. An effective educational system is essential to three things that Americans have valued more than enlightment: the opportunity for individual advancement, a prosperous economy, and political and social stability. (MLW)

Elements of Successful School Reentry after Psychiatric Hospitalization

ERIC Educational Resources Information Center

Clemens, Elysia V.; Welfare, Laura E.; Williams, Amy M.

2011-01-01

Psychiatric hospitalization is an intensive intervention designed to stabilize adolescents who are experiencing an acute mental health crisis. Reintegrating to school after discharge from psychiatric hospitalization can be overwhelming for many adolescents (E. V. Clemens, L. E. Welfare, & A. M. Williams, 2010). The authors used a consensual…

The Complexity of Threats to Nuclear Strategic Deterrence Posture

DTIC Science & Technology

2017-02-07

environment, a status quo but things are improving, a status quo but things are getting worse, and the occurrence of a game -changing event. Findings...adversaries. This information will certainly inform this research, as game changing technology will in due course affect the strategic nuclear deterrence...Congressional Research Service, RAND Corporation, and certain peer-reviewed and scholarly articles. The fourth independent variable, “Occurrence of a Game

Taking a Quantum Leap in Cyber Deterrence

DTIC Science & Technology

2010-02-17

calculus that weighs the cost and benefit of an action. 76 According to John Mearsheimer, that decision calculus is ―a function of the costs and...frame an adversary‘s rationale and decision calculus . 82 Understanding a group‘s rationale helps frame a strategy for deterrence. Emanuel Adler...only remaining option. Mearsheimer‘s decision calculus described above indicates that if the cost of an attack is high, or the probability of

Conflict Containment in the Balkans: Testing Extended Deterrence.

DTIC Science & Technology

1995-03-01

STATEMENT 12b. DISTRIBUTION CODE Approved for public release; distribution is unlimited. 13. ABSTRACT This thesis critically analyzes a prominent theoretical...Containment 15. NUMBER OF in the Balkans; Deterrence; Coercive Diplomacy; Balance of Forces. PAGES: 161 16. PRICE CODE 17. SECURITY CLASSIFI- 18. SECURITY...Department of National Security Affai sAccesion For NTIS CRA&I DTtC TAB Unannounced Justifca ........... By- Distribution Availability Codes Avail and/or Dist

Perseverance of Power: The Relevancy of Nuclear Deterrence in the Future

DTIC Science & Technology

2013-06-01

22 James Wood Jr. Forsyth, B. Chance Saltzman , and Gary Jr. Schaub, "Rememberance of Things Past," Strategic Studies Quarterly (Spring 2010): 75...Deterrence Now: 152. 117 Reagan, "Nuclear Weapons Employment Policy". 118 Forsyth, Saltzman , and Schaub, "Rememberance of Things Past," 75. 119 See notes 96...international order. 122 Forsyth, Saltzman , and Schaub, "Rememberance of Things Past," 80

Strategic Flexibility to Deter in the Asia Pacific

DTIC Science & Technology

2016-01-01

result will occur. This posture, while often effective , ac- tually limits response options for policy makers, essentially requiring the establishment...to the de- terrent effect of a range of policy options supported by the breadth of the nation’s instruments of power and “unguided by an overt...deterrence policy”; some define this deterrent effect as dissuasion, as does this article, although in the Department of Defense’s (DOD) joint doctrine

Signaling the End of Deterrence Afforded by Dual Capable Aircraft

DTIC Science & Technology

2017-04-06

INTRODUCTION For more than 60 years, the Unites States and Europe relied on fighter aircraft capable of executing conventional and nuclear strike...missions. Known as dual-capable aircraft (DCA), these fighters were an integral part of the US extended nuclear deterrence strategy in Asia and Europe...force structure, sustainment and modernization by the US and Allied nations allowed tactical nuclear forces to atrophy. Starting in 2010, the US and

Challenging Minimum Deterrence: Articulating the Contemporary Relevance of Nuclear Weapons

DTIC Science & Technology

2016-07-13

Command and Control: Nuclear Weapons, the Damascus Accident , and the Illusion of Safety (New York: Penguin Press, 2013), 484. 36. Keir A. Lieber and...Remembrance of Things Past,” 78. 53. Scott D. Sagan, The Limits of Safety: Organizations, Accidents , and Nuclear Weapons (Princeton, NJ: Princeton...16 | Air & Space Power Journal Challenging Minimum Deterrence Articulating the Contemporary Relevance of Nuclear Weapons Maj Joshua D. Wiitala, USAF

Cyber Attacks, Attribution, and Deterrence: Three Case Studies

DTIC Science & Technology

2015-05-23

threat informs his decision about the appropriate deterrent counter-threats. There tend to be three camps in general: Minimalists , Moderates, and...Alarmists. Minimalists do not require much explanation because they are the authors who believe that cyber does not pose any significant threat...Armageddon.”32 Amongst the minimalists are Lawrence Freedman and Thomas Rid. Freedman grants discussion of cyber attacks a scant two pages in his seven

Deterrence and Risk Preferences in Sequential Attacker-Defender Games with Continuous Efforts.

PubMed

Payyappalli, Vineet M; Zhuang, Jun; Jose, Victor Richmond R

2017-11-01

Most attacker-defender games consider players as risk neutral, whereas in reality attackers and defenders may be risk seeking or risk averse. This article studies the impact of players' risk preferences on their equilibrium behavior and its effect on the notion of deterrence. In particular, we study the effects of risk preferences in a single-period, sequential game where a defender has a continuous range of investment levels that could be strategically chosen to potentially deter an attack. This article presents analytic results related to the effect of attacker and defender risk preferences on the optimal defense effort level and their impact on the deterrence level. Numerical illustrations and some discussion of the effect of risk preferences on deterrence and the utility of using such a model are provided, as well as sensitivity analysis of continuous attack investment levels and uncertainty in the defender's beliefs about the attacker's risk preference. A key contribution of this article is the identification of specific scenarios in which the defender using a model that takes into account risk preferences would be better off than a defender using a traditional risk-neutral model. This study provides insights that could be used by policy analysts and decisionmakers involved in investment decisions in security and safety. © 2017 Society for Risk Analysis.

The Nuclear Posture Review (NPR) : are we safer?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brune, Nancy E.

2010-07-01

Nuclear Posture Review (NPR) is designed to make world safer by reducing the role of U.S. nuclear weapons and reducing the salience of nuclear weapons. U.S. also seeks to maintain a credible nuclear deterrent and reinforce regional security architectures with missile defenses and other conventional military capabilities. But recent studies suggest that nuclear proliferation is a direct response to the perceived threat of U.S. conventional capabilities not U.S. nuclear stockpile. If this is true, then the intent of the NPR to reduce the role and numbers of nuclear weapons and strengthen conventional military capabilities may actually make the world lessmore » safe. First stated objective of NPR is to reduce the role and numbers of U.S. nuclear weapons, reduce the salience of nuclear weapons and move step by step toward eliminating them. Second stated objective is a reaffirmation of U.S. commitment to maintaining a strong deterrent which forms the basis of U.S. assurances to allies and partners. The pathway - made explicit throughout the NPR - for reducing the role and numbers of nuclear weapons while maintaining a credible nuclear deterrent and reinforcing regional security architectures is to give conventional forces and capabilities and missile defenses (e.g. non-nuclear elements) a greater share of the deterrence burden.« less

Deterrent effects of demerit points and license sanctions on drivers' traffic law violations using a proportional hazard model.

PubMed

Lee, Jaeyeong; Park, Byung-Jung; Lee, Chungwon

2018-04-01

Current traffic law enforcement places an emphasis on reducing accident risk from human factors such as drunk driving and speeding. Among the various strategies implemented, demerit points and license sanction systems have been widely used as punitive and educational measures. Limitations, however, exist in previous studies in terms of estimating the interaction effects of demerit points and license sanctions. To overcome such limitations, this work focused on identifying the interaction effects of demerit points and license sanctions on driver traffic violation behavior. The interaction deterrent effects were assessed by using a Cox's proportional hazard model to provide a more accurate and unbiased estimation. For this purpose, five years of driver conviction data was obtained from the Korea National Police Agency (KNPA). This data included personal characteristics, demerit point accumulation and license sanction status. The analysis showed that accumulated demerit points had specific deterrent effects. Additionally, license revocation showed consistent and significant deterrent effects, greater than those for suspension. Male drivers under their 30s holding a motorcycle license were identified as the most violation-prone driver group, suggesting that stricter testing for the acquisition of a motorcycle driver's license is needed. Copyright © 2018 Elsevier Ltd. All rights reserved.

Laboratory-based testing to evaluate abuse-deterrent formulations and satisfy the Food and Drug Administration's recommendation for Category 1 Testing.

PubMed

Altomare, Christopher; Kinzler, Eric R; Buchhalter, August R; Cone, Edward J; Costantino, Anthony

The US Food and Drug Administration (FDA) considers the development of abuse-deterrent formulations of solid oral dosage forms a public health priority and has outlined a series of premarket studies that should be performed prior to submitting an application to the Agency. Category 1 studies are performed to characterize whether the abuse-deterrent properties of a new formulation can be easily defeated. Study protocols are designed to evaluate common abuse patterns of prescription medications as well as more advanced methods that have been reported on drug abuse websites and forums. Because FDA believes Category 1 testing should fully characterize the abuse-deterrent characteristics of an investigational formulation, Category 1 testing is time consuming and requires specialized laboratory resources as well as advanced knowledge of prescription medication abuse. Recent Advisory Committee meetings at FDA have shown that Category 1 tests play a critical role in FDA's evaluation of an investigational formulation. In this article, we will provide a general overview of the methods of manipulation and routes of administration commonly utilized by prescription drug abusers, how those methods and routes are evaluated in a laboratory setting, and discuss data intake, analysis, and reporting to satisfy FDA's Category 1 testing requirements.

Bringing Space Crisis Stability Down to Earth

DTIC Science & Technology

2015-01-01

President Hu Jintao agreed during one of their first meetings that “the two countries have common interests in promoting the peaceful use of outer...linked, and they are linked not only for the United States, but also in- creasingly for China and other countries that rely on space systems to

Multidimensional Networking: A Response to the Needs of Homeless Families.

ERIC Educational Resources Information Center

Hutchison, William J.; And Others

1986-01-01

Draws on models of social networking to present findings from a six-year study of homeless families who received treatment at the Salvation Army Lodge in St. Louis, Missouri. Presents a four-stage model of treatment: the crisis, stabilization, relocation, and follow-up stages. (Author/ABB)

New Capabilities for Hostile Environments on Z Grand Challenge LDRD - Final Status

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuneo, Michael E.; Griffin, P. J.; Balch, D. K.

2016-10-01

The purpose of this project was to develop new physical simulation capabilities in order to support the science-based qualification of nonnuclear weapon components in hostile radiation environments. The project contributes directly to the goals of maintaining a safe, secure, and effective US nuclear stockpile, maintaining strategic deterrence at lower nuclear force levels, extending the life of the nuclear deterrent capability, and to be ready for technological surprise.

Boom or Bust: Britain’s Nuclear Deterrent Beyond 2025

DTIC Science & Technology

2012-04-26

Labour government of the day, spelt out a commitment to replace Britain’s Submarine Launched Ballistic Missile (SLBM) nuclear deterrent with a similar...global and national economies; banks collapsed, markets went into turmoil and the extent of government debts and borrowing was laid bare. The fiscal...disarmament. In 2010 Nick Clegg stated that: "Neither Labour nor the Conservatives are prepared to question spending tens of billions of pounds on a like

From War to Deterrence? Israel-Hezbollah Conflict Since 2006

DTIC Science & Technology

2014-05-01

Israeli Air Force (IAF) strike on a Syrian reactor in September 2007, the issue of the Lebanese front, although unsettled, was moved to the...widespread con- fusion over the exact level of readiness and coverage of its missile defense architecture. Given the current passion of Israeli...Variations on a Theme: The Conceptual - ization of Deterrence in Israeli Strategic Thinking,” Security Stud- ies, Vol. 7, No. 3, Spring 1998, pp. 145-181

From Power Projection To Power Protection: Revitalizing Conventional Deterrence In NATO

DTIC Science & Technology

2016-06-01

deterrence, in its broadest sense, means persuading an opponent not to initiate a specific action because the perceived benefits do not justify...relies on an extended calculation of adversary costs and benefits . A calculation for denial must only look at the respective forces for that particular...force to a forward deployment of an infantry company. A significant benefit of power projection is that it allows husbanding of resources at home or at

Can Counter-Gang Models be Applied to Counter ISIS’s Internet Recruitment Campaign

DTIC Science & Technology

2016-06-10

limitation that exists is the lack of reliable statistics from social media companies in regards to the quantity of ISIS-affiliated sites, which exist on... statistics , they have approximately 320-million monthly active users with thirty-five-plus languages supported and 77 percent of accounts located...Justice and Delinquency Prevention program. For deterrence-based models, the primary point of research is focused deterrence models with emphasis placed

Extended Deterrence: Taking Stock of Current Policy and Updating the Research and PME Agendas

DTIC Science & Technology

2014-08-01

Conference and Venue The INSS “Extended Deterrence: Taking Stock of Current policy and Updating the Research and PME Agendas” workshop took place...Force Institute for National Security Studies ( INSS ) which is sponsored by the Air Force Strategic Plans and Policy Division (A5XP). Subject...emerging strategic environment? INSS anticipated that the discussion would be influenced by current developments such as: • The Russian incursion

Realities of Deterrence and Retaliatory Options to Attacks in Space and Cyberspace

DTIC Science & Technology

2012-02-15

instruments of power. It is an evolving landscape of electronic and kinetic threats that may merely scratch the surface of what might be at an...communications satellite; and in 2008, during two separate attacks, hackers accessed National Aeronautics and Space Administration ( NASA ) telemetry...unacceptable and to be avoided.23,24 Deterrence between the United States and the Soviet Union was bi-polar, between known adversaries. This is not

Abuse-deterrent formulations of prescription opioid analgesics in the management of chronic noncancer pain.

PubMed

Hale, Martin E; Moe, Derek; Bond, Mary; Gasior, Maciej; Malamut, Richard

2016-10-01

Misuse, abuse and diversion of prescription opioid analgesics represent a global public health concern. The development of abuse-deterrent formulations (ADFs) of prescription opioid analgesics is an important step toward reducing abuse and diversion of these medications, as well as potentially limiting medical consequences when misused or administered in error. ADFs aim to hinder extraction of the active ingredient, prevent administration through alternative routes and/or make abuse of the manipulated product less attractive, less rewarding or aversive. However, opioid ADFs may still be abused via the intended route of administration by increasing the dose and/or dosing frequency. The science of abuse deterrence and the regulatory landscape are still relatively new and evolving. This paper reviews the current status of opioid ADFs, with particular focus on different approaches that can be used to deter abuse, regulatory considerations and implications for clinical management.

National military strategy in the post cold war era: Nuclear deterrence or an alternative. Study project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pooley, G.R.

In the aftermath of the Cold War it becomes necessary to explore the validity of nuclear deterrence as the cornerstone of the United States National Military Strategy for the upcoming period of transition in international relations. Using the current world situation as a starting point, the evolving trends in international relations, arms control and nuclear proliferation, the strategic threat and the evolution of technology will be analyzed in an effort to forecast the complexion of international relations twenty years hence. Then, within this context, nuclear deterrence and a non nuclear alternative nonoffensive defense, proposed by the Danish political scientist, Bjornmore » Moller, will be examined. In the final analysis, this project will suggest an appropriate direction for the evolution of the United States' National Military Strategy which, in the opinion of the author, provides the best probability for long term world peace.« less

In defiance of nuclear deterrence: anti-nuclear New Zealand after two decades.

PubMed

Reitzig, Andreas

2006-01-01

In 1984, nuclear-armed and nuclear-powered vessels were banned from New Zealand to express the country's rejection of the nuclear deterrence concept. This led to a disagreement with the United States. Today, the ban on nuclear-powered ships is the only element of the nuclear-free legislation that still strains US-New Zealand relations. This article presents the reasons for the ban on nuclear-powered ships, which include scientific safety concerns, a symbolic rejection of the nuclear deterrence posture, and patriotic factors such as a nuclear-free national identity. The military and economic consequences of the ban are also examined. Since the ban on nuclear-powered vessels appears to be neither widely known abroad nor commonly recognised as a supportive disarmament measure outside New Zealand, it is concluded that whatever the future of this ban will be, New Zealand's anti-nuclear image will remain known internationally through the ban on nuclear arms.

Why leaders punish: A power perspective.

PubMed

Mooijman, Marlon; van Dijk, Wilco W; Ellemers, Naomi; van Dijk, Eric

2015-07-01

We propose that power fundamentally changes why leaders punish and we develop a theoretical model that specifies how and why this occurs. Specifically, we argue that power increases the reliance on deterrence, but not just deserts, as a punishment motive and relate this to power fostering a distrustful mindset. We tested our model in 9 studies using different instantiations of power, different measurements and manipulations of distrust while measuring punishment motives and recommended punishments across a number of different situations. These 9 studies demonstrate that power fosters distrust and hereby increases both the reliance on deterrence as a punishment motive and the implementation of punishments aimed at deterrence (i.e., public punishments, public naming of rule breakers and punishments with a mandatory minimum). We discuss the practical implications for leaders, managers and policymakers and the theoretical implications for scholars interested in power, trust, and punishments. (c) 2015 APA, all rights reserved).

''Whither Deterrence?'' A Brief Synopsis May, 2002

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poppe, C; Vergino, E; Barker, R

To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US' first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use ofmore » nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In this study, we present four futures as a tool for planners who must think ahead fifteen years or more, rather than a prediction of the future. None of the four futures will emerge in just the way we have described. Fifteen years from now, some mix of these futures is more likely, or perhaps we will see a trend towards one of the futures, but with the possibility that any of the other three could appear, perhaps quite swiftly. Any future will undoubtedly contain its own kind of unpleasant surprises and, in contrast to the Cold War; the possession of enormous nuclear-response and conventional-response capability may not be sufficient to deter these from happening. However, there are other tools that the US must include as part of its strategy and security policy in addition to deterrence, specifically dissuasion, defense, destruction, and assurance. Rather than rely on the Cold-War concept of deterrence, future security policy should be built upon the appropriate mix of these elements as a way to steer us toward a more favorable future, while ensuring that we are prepared for the kinds of surprises associated with far less favorable futures. In this study, we have defined three unfavorable futures to be avoided, and one future that represents, we believe, a more desirable global situation than the first three, but still not entirely benign. Our security policy should be defined to avoid or prevent the first three, which we have entitled ''Nuclear Giants, Global Terror'', and ''Regional Nuclear Tension and Use'', and steer us toward a more favorable future, ''Dynamic Cooperation''. We have examined the implications for both policy and military capability that are posed by these different futures. The result often raises more questions than we are able to answer without additional study-however, our primary purpose was to clarify the issues, to identify. what we believe we know, what we don't know, and where more study and effort are needed. Nevertheless, in preparing for unfavorable futures, we must also identify and plan the future we want. This study emphasizes that a desirable future in 2015 would be characterized by peaceful resolution of conflict, growing worldwide economic prosperity, an effective non-proliferation regime, the ability of the United States to control its own destiny without conflict, and expansion of political and economic freedom. Security policies, even in the face of unpleasant futures, should be crafted so as enhance, rather than diminish, these desired goals.« less

Chaotic Attractor Crisis and Climate Sensitivity: a Transfer Operator Approach

NASA Astrophysics Data System (ADS)

Tantet, A.; Lucarini, V.; Lunkeit, F.; Dijkstra, H. A.

2015-12-01

The rough response to a smooth parameter change of some non-chaotic climate models, such as the warm to snowball-Earth transition in energy balance models due to the ice-albedo feedback, can be studied in the framework of bifurcation theory, in particular by analysing the Lyapunov spectrum of fixed points or periodic orbits. However, bifurcation theory is of little help to study the destruction of a chaotic attractor which can occur in high-dimensional General Circulation Models (GCM). Yet, one would expect critical slowing down to occur before the crisis, since, as the system becomes susceptible to the physical instability mechanism responsible for the crisis, it turns out to be less and less resilient to exogenous perturbations and to spontaneous fluctuations due to other types of instabilities on the attractor. The statistical physics framework, extended to nonequilibrium systems, is particularly well suited for the study of global properties of chaotic and stochastic systems. In particular, the semigroup of transfer operators governs the evolution of distributions in phase space and its spectrum characterises both the relaxation rate of distributions to a statistical steady-state and the stability of this steady-state to perturbations. If critical slowing down indeed occurs in the approach to an attractor crisis, the gap in the spectrum of the semigroup of transfer operators is expected to shrink. We show that the chaotic attractor crisis due to the ice-albedo feedback and resulting in a transition from a warm to a snowball-Earth in the Planet Simulator (PlaSim), a GCM of intermediate complexity, is associated with critical slowing down, as observed by the slower decay of correlations before the crisis (cf. left panel). In addition, we demonstrate that this critical slowing down can be traced back to the shrinkage of the gap between the leading eigenvalues of coarse-grained approximations of the transfer operators and that these eigenvalues capture the fundamental features of the attractor crisis (cf. right panel). Finally, that the spectral gap is small close to the crisis suggests that the linear concept of Climate Sensitivity may be applied only far from an attractor crisis.

Oviposition-altering and ovicidal potentials of five essential oils against female adults of the dengue vector, Aedes aegypti L.

PubMed

Warikoo, Radhika; Wahab, Naim; Kumar, Sarita

2011-10-01

The oviposition deterrence and ovicidal potential of five different essential oils, peppermint oil (Mentha piperita), basil oil (Ocimum basilicum), rosemary oil (Rosemarinus officinalis), citronella oil (Cymbopogon nardus), and celery seed oil (Apium graveolens), were assessed against female adults of the dengue vector, Aedes aegypti L. Multiple concentration tests were carried out where cups containing 1 mL of different concentrations (100%, 10%, 1%, 0.1%) of the oils and 199 mL of water were used for oviposition. The number of eggs laid and the larvae hatched in each cup were scored to evaluate the oviposition deterrent and ovicidal potentials of the oils. Our investigations revealed that the addition of 100% oil (pure oil) caused complete oviposition deterrence except in A. graveolens which resulted in 75% effective repellency. The use of 10% oil resulted in the maximum deterrence of 97.5% as shown by the M. piperita oil while other oils caused 36-97% oviposition deterrence as against the control. The oviposition medium with 1% oil showed decreased deterrent potential with 30-64% effective repellency, the M. piperita oil being exceptional. However, as the concentrations of the oil were reduced further to 0.1%, the least effective oil observed was A. graveolens (25% ER). Also, the M. piperita oil showed much reduced activity (40%) as compared to the control, while the other oils exhibited 51-58% repellency to oviposition. The studies on the ovicidal effects of these oils revealed that the eggs laid in the water with 100% essential oils did not hatch at all, whereas when 10% oils were used, only the R. officinalis oil resulted in 28% egg hatch. At lower concentrations (1%), the oils of M. piperita, O. basilicum, and C. nardus showed complete egg mortality while those of A. graveolens and R. officinalis resulted in 71% and 34% egg hatches, respectively. When used at 0.1%, the O. basilicum oil was found to be the only effective oil with 100% egg mortality, whereas other oils resulted in 16-76% egg mortality, the least mortality caused by the A. graveolens oil. These results suggest that these essential oils can be employed in a resistance-management program against A. aegypti. Further detailed research is needed to identify the active ingredient in the extracts and implement the effective mosquito management program.

Bed bug deterrence

PubMed Central

2010-01-01

A recent study in BMC Biology has determined that the immature stage of the bed bug (the nymph) signals its reproductive status to adult males using pheromones and thus avoids the trauma associated with copulation in this species. The success of this nymphal strategy of deterrence is instructive. Against the background of increasing problems with bed bugs, this research raises the question whether pheromones might be used to control them. See research article http://www.biomedcentral.com/1741-7007/8/121 PMID:20828375

Tacit Knowledge Involvement in the Production of Nuclear Weapons: A Critical Component of a Credible US Nuclear Deterrent in the 21st Century

DTIC Science & Technology

2013-02-14

important in sustaining a credible nuclear deterrent without testing. Thinking in the early days of the Manhattan Project was that designing a nuclear...weapon would occur quickly. Renowned physicist Edward Teller recalled being discouraged from joining the Manhattan Project at Los Alamos National...difficulties with their nuclear program in the early years despite involvement with portions of the Manhattan Project . With permission, the British

Donating blood: a meta-analytic review of self-reported motivators and deterrents.

PubMed

Bednall, Timothy C; Bove, Liliana L

2011-10-01

Although research on blood donor motivation abounds, most studies have typically focused on small sets of variables, used different terminology to label equivalent constructs, and have not attempted to generalize findings beyond their individual settings. The current study sought to synthesize past findings into a unified taxonomy of blood donation drivers and deterrents and to estimate the prevalence of each factor across the worldwide population of donors and eligible nondonors. Primary studies were collected, and cross-validated categories of donation motivators and deterrents were developed. Proportions of first-time, repeat, lapsed, apheresis, and eligible nondonors endorsing each category were calculated. In terms of motivators, first-time and repeat donors most frequently cited convenience, prosocial motivation, and personal values; apheresis donors similarly cited the latter 2 motivators and money. Conversely, lapsed donors more often cited collection agency reputation, perceived need for donation, and marketing communication as motivators. In terms of deterrents, both donors and nondonors most frequently referred to low self-efficacy to donate, low involvement, inconvenience, absence of marketing communication, ineffective incentives, lack of knowledge about donating, negative service experiences, and fear. The integration of past findings has yielded a comprehensive taxonomy of factors influencing blood donation and has provided insight into the prevalence of each factor across multiple stages of donors' careers. Implications for collection agencies are discussed. Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical Constituents of Supercritical Extracts from Alpinia officinarum and the Feeding Deterrent Activity against Tribolium castaneum.

PubMed

Xin, Mintong; Guo, Shanshan; Zhang, Wenjuan; Geng, Zhufeng; Liang, Junyu; Du, Shushan; Deng, Zhiwei; Wang, Yongyan

2017-04-18

Alpinia officinarum has been confirmed to possess bioactivities against some pests. In this work, a sample was obtained from A. officinarum rhizomes by supercritical fluid CO₂ extraction (SFE). According to GC-MS analysis, the main chemical components for SFE-sample included benzylacetone (26.77%), 1,7-diphenyl-5-hydroxy-3-heptanone (17.78%), guaiacylacetone (10.03%) and benzenepropanal (7.42%). The essential oil of A. officinarum rhizomes (LD 50 = 20.71 μg/adult) exhibited more contact toxicity than SFE extract (LD 50 = 82.72 μg/adult) against Tribolium castaneum . From SFE extracts, one new compound, 1-phenyl-4-(16,17-dimethyl-9,13-octadiene)-5-isopentenyl-7-(4"-methoxyl-3"-hydroxyl-phenyl)-3-heptanone ( 3 ), together with five known compounds identified as 5-hydroxy-1,7-diphenyl-3-heptanone ( 1 ), 1,7-diphenyl-4-hepten-3-one ( 2 ), galangin ( 4 ), galangin-3-methyl ether ( 5 ) and pinocembrin ( 6 ), were isolated and their feeding deterrent activities against T. castaneum adults were assessed. It was found that compounds 1 - 6 had feeding deterrent activities against T. castaneum with feeding deterrent indices of 18.21%, 18.94%, 19.79%, 26.99%, 20.34%, and 35.81%, respectively, at the concentration of 1500 ppm. Hence, the essential oil and SFE extracts/compounds of A. officinarum rhizomes represent promising alternatives in the control of T. castaneum adults.

The effects of herbal essential oils on the oviposition-deterrent and ovicidal activities of Aedes aegypti (Linn.), Anopheles dirus (Peyton and Harrison) and Culex quinquefasciatus (Say).

PubMed

Siriporn, P; Mayura, S

2012-03-01

The effect of oviposition-deterrent and ovicidal of seven essential oils were evaluated towards three mosquito vectors, Aedes aegypti, Anopheles dirus and Culex quinquefasciatus. The oviposition activity index (OAI) values of six essential oils namely Cananga odorata, Cymbopogon citratus, Cymbopogon nardus, Eucalyptus citriodora, Ocimum basilicum and Syzygium aromaticum indicated that there were more deterrent than the control whereas Citrus sinensis oil acted as oviposition attractant. At higher concentration (10%) of Ca. odorata (ylang ylang flowers) showed high percent effective repellency (ER) against oviposition at 99.4% to Ae. aegypti, 97.1% to An. dirus and 100% to Cx. quinquefasciatus, respectively. The results showed that mean numbers of eggs were lower in treated than in untreated water. In addition, there was an inverse relationship between essential oil concentrations and ovicidal activity. As the concentration of essential oil increased from 1%, 5% and up to 10% conc., the hatching rate decreased. The essential oil of Ca. odorata at 10% conc. gave minimum egg hatch of 10.4% (for Ae. aegypti), 0.8% (for An. dirus) and 1.1% (for Cx. quinquefasciatus) respectively. These results clearly revealed that the essential oil of Ca. odorata served as a potential oviposition-deterrent and ovicidal activity against Ae. aegypti, An. dirus and Cx. quinquefasciatus.

Am I my brother's (or customer's or tenant's) keeper? Economic and ethical aspects to the California Supreme Court's struggle with the issue of landowner's standard of care.

PubMed

Hodson, T J; Englander, F; Englander, V

2001-07-01

The Supreme Court of California has ruled on several cases involving the question of to what extent a possessor of land is liable for the harm to customers or tenants occurring when a third party commits a criminal act against the customers or tenants present on the land. This paper reviews the historical development of this aspect of negligence law and analyzes the ethical and economic efficiency implications of ascribing legal responsibility for such crimes to: a) local government, b) the possessor of land, c) the customer, and d) the criminal. For example, is there an effort by the judicial system to substitute deterrence from criminal acts provided by possessors of land (i.e., specific deterrence) for the general deterrence traditionally provided through the use of police powers by local government? Analysis indicates that specific deterrence may be more effective in changing the location of criminal acts than in reducing the level of criminal activities. Also, the expense of complying with the legal responsibilities of protecting customers and clients may be especially high in high-crime, low-income areas, thus forcing commercial establishments to move or go out of business. Thus, we have a troubling tradeoff: compensating individual crime victims in a high-crime area could ultimately deprive the residents of basic economic opportunities.

Why Do Blood Donors Lapse or Reduce Their Donation's Frequency?

PubMed

Charbonneau, Johanne; Cloutier, Marie-Soleil; Carrier, Élianne

2016-01-01

Finding effective ways to retain blood donors is crucial. This study seeks to compare, in a context of a voluntary and nonremunerated system, donor demographics and deterrents to blood donation among plasma/platelet donors (PPDs), regular whole blood donors (WBDs), and lapsed whole blood donors (LWBD). Among 1879 participants to a survey on motivations, time use, and blood donation, 207 WBDs (26%) and 148 PPDs (31%) said that they reduced their donation frequency over the last 5 years. Participants to this survey also included 609 LWBDs, who did not donate in the past 5 years. We asked about reasons why they reduce or cease to donate blood and demographic variables. χ(2) Tests were completed to determine which deterrents stand out across the 3 blood donor groups. The deterrent indicating the highest percentage was "time constraints related to work or studies" (43% for all respondents). Comparison of WBDs, LWBDs, and PPDs shows that results for 7 deterrents were statistically different between the 3 groups. Obstacles to donating blood also vary based on sex, age (life course), and level of education. Blood collection agencies should consider developing new retention strategies tailored to blood donors, taking into account the specific profiles of female/male donors, events that typically occur at various stages of life, and particular challenges associated with differences in levels of education. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

The impact of the economic crisis on occupational injuries.

PubMed

de la Fuente, Verónica Sedano; López, Miguel A Camino; González, Ignacio Fontaneda; Alcántara, Oscar J González; Ritzel, Dale O

2014-02-01

The potential influence of the current economic crisis on occupational accident rates and accident severity is studied in an analysis of all workplace accidents that occurred in Spain throughout the period 2000-2009. The investigation confirms that occupational accidents in Spain are affected by the current economic crisis, which has provoked a sharp fall in both the number of accidents and the probability of having one. This may be justified by certain factors such as age, gender, length of service, size of the firm, and the employment stability of the injured worker. The influence of these factors is analyzed. The economic crises seems to provoke a sort of "natural selection" in the labor market and only the best adapted tend to remain (older workers, with more experience, a higher percentage of women, more workers in larger companies and permanent contracts), all of which means that the probability of workers having an injury is considerably reduced. Copyright © 2013 Elsevier Ltd and National Safety Council. All rights reserved.

Second Modernity, (In)equality, and Social (In)justice

ERIC Educational Resources Information Center

Clay, John; George, Rosalyn

2016-01-01

It is important to realize that the economic climate since the banking crisis in 2007 has seen the rate of income and wealth inequality accelerate. This has reached the point where concerns for political, economic, and social stability have been raised by those representing the pillars and foundations of institutions that represent the market…

Uganda: Current Conditions and the Crisis in North Uganda

DTIC Science & Technology

2010-05-19

constitution_1995. pdf . 5 John Kakande. “Museveni Speaks on 3rd Term.” The New Vision, January 3, 2003. 6 “President Should Listen to Old Friends...tea, and to a lesser extent, maize . Crop production has been hampered by security concerns in the northern and western regions of Uganda. To stabilize

Road to Equality in South African Education: A Qualitative Study

ERIC Educational Resources Information Center

O'Brien, Kevin

2010-01-01

South Africa is currently experiencing a crisis in its educational systems that if not addressed, could threaten the stability of the newly established democracy. A lack of access to quality education and severe shortage of skilled trained educators is perpetuating vestiges of the old apartheid state in the nation. Approximately 6,000 students…

Learning: Meeting the Challenges of Older Adulthood.

ERIC Educational Resources Information Center

Wolf, Mary Alice

Erik Erikson's model (1963, 1982) is most useful to an understanding of development and aging. He describes lifelong growth as related to tasks that must be performed. At each stage of life, times of stability are followed by developmental crises. Upon resolving the crisis, the individual can enjoy the particular beauty and security of that…

Systemic risk in banking ecosystems.

PubMed

Haldane, Andrew G; May, Robert M

2011-01-20

In the run-up to the recent financial crisis, an increasingly elaborate set of financial instruments emerged, intended to optimize returns to individual institutions with seemingly minimal risk. Essentially no attention was given to their possible effects on the stability of the system as a whole. Drawing analogies with the dynamics of ecological food webs and with networks within which infectious diseases spread, we explore the interplay between complexity and stability in deliberately simplified models of financial networks. We suggest some policy lessons that can be drawn from such models, with the explicit aim of minimizing systemic risk.

Changes in the dispensing of opioid medications in Canada following the introduction of a tamper-deterrent formulation of long-acting oxycodone: a time series analysis.

PubMed

Gomes, Tara; Mastorakos, Andrea; Paterson, J Michael; Sketris, Ingrid; Caetano, Patricia; Greaves, Simon; Henry, David

2017-11-22

In February 2012, a reformulated tamper-deterrent form of long-acting oxycodone, OxyNeo, was introduced in Canada. We investigated the impact of the introduction of OxyNeo on patterns of opioid prescribing. We conducted population-based, cross-sectional analyses of opioid dispensing in Canada between 2008 and 2016. We estimated monthly community pharmacy dispensing of oral formulations of codeine, morphine, hydromorphone and oxycodone, and a transdermal formulation of fentanyl, and converted quantities to milligrams of morphine equivalents (MMEs) per 1000 population. We used time series analysis to evaluate the effect of the introduction of OxyNeo on these trends. National dispensing of long-acting opioids fell by 14.9% between February 2012 and April 2016, from 36 098 MMEs to 30 716 MMEs per 1000 population ( p < 0.01). This effect varied across Canada and was largest in Ontario (reduction of 22.8%) ( p = 0.01) and British Columbia (reduction of 30.0%) ( p = 0.01). The national rate of oxycodone dispensing fell by 46.4% after the introduction of OxyNeo ( p < 0.001); this was partially offset by an increase of 47.8% in hydromorphone dispensing ( p < 0.001). Although dispensing of immediate-release opioids was a substantial contributor to overall population opioid exposure across Canada, it was unaffected by the introduction of OxyNeo ( p > 0.05 in all provinces). The findings suggest that the introduction of a tamper-deterrent formulation of long-acting oxycodone in Canada, against a background of changing public drug benefits, was associated with sustained changes in selection of long-acting opioids but only small changes in the quantity of long-acting opioids dispensed. This illustrates the limited effect a tamper-deterrent formulation and associated coverage policy can have when other, non-tamper-deterrent alternatives are readily available. Copyright 2017, Joule Inc. or its licensors.

Evaluating the Effectiveness of an Ultrasonic Acoustic Deterrent for Reducing Bat Fatalities at Wind Turbines.

PubMed

Arnett, Edward B; Hein, Cris D; Schirmacher, Michael R; Huso, Manuela M P; Szewczak, Joseph M

2013-01-01

Large numbers of bats are killed by wind turbines worldwide and minimizing fatalities is critically important to bat conservation and acceptance of wind energy development. We implemented a 2-year study testing the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at a wind energy facility in Pennsylvania. We randomly selected control and treatment turbines that were searched daily in summer and fall 2009 and 2010. Estimates of fatality, corrected for field biases, were compared between treatment and control turbines. In 2009, we estimated 21-51% fewer bats were killed per treatment turbine than per control turbine. In 2010, we determined an approximate 9% inherent difference between treatment and control turbines and when factored into our analysis, variation increased and between 2% more and 64% fewer bats were killed per treatment turbine relative to control turbines. We estimated twice as many hoary bats were killed per control turbine than treatment turbine, and nearly twice as many silver-haired bats in 2009. In 2010, although we estimated nearly twice as many hoary bats and nearly 4 times as many silver-haired bats killed per control turbine than at treatment turbines during the treatment period, these only represented an approximate 20% increase in fatality relative to the pre-treatment period for these species when accounting for inherent differences between turbine sets. Our findings suggest broadband ultrasound broadcasts may reduce bat fatalities by discouraging bats from approaching sound sources. However, effectiveness of ultrasonic deterrents is limited by distance and area ultrasound can be broadcast, in part due to rapid attenuation in humid conditions. We caution that an operational deterrent device is not yet available and further modifications and experimentation are needed. Future efforts must also evaluate cost-effectiveness of deterrents in relation to curtailment strategies to allow a cost-benefit analysis for mitigating bat fatalities.

Evaluating the Effectiveness of an Ultrasonic Acoustic Deterrent for Reducing Bat Fatalities at Wind Turbines

PubMed Central

Arnett, Edward B.; Hein, Cris D.; Schirmacher, Michael R.; Huso, Manuela M. P.; Szewczak, Joseph M.

2013-01-01

Large numbers of bats are killed by wind turbines worldwide and minimizing fatalities is critically important to bat conservation and acceptance of wind energy development. We implemented a 2-year study testing the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at a wind energy facility in Pennsylvania. We randomly selected control and treatment turbines that were searched daily in summer and fall 2009 and 2010. Estimates of fatality, corrected for field biases, were compared between treatment and control turbines. In 2009, we estimated 21–51% fewer bats were killed per treatment turbine than per control turbine. In 2010, we determined an approximate 9% inherent difference between treatment and control turbines and when factored into our analysis, variation increased and between 2% more and 64% fewer bats were killed per treatment turbine relative to control turbines. We estimated twice as many hoary bats were killed per control turbine than treatment turbine, and nearly twice as many silver-haired bats in 2009. In 2010, although we estimated nearly twice as many hoary bats and nearly 4 times as many silver-haired bats killed per control turbine than at treatment turbines during the treatment period, these only represented an approximate 20% increase in fatality relative to the pre-treatment period for these species when accounting for inherent differences between turbine sets. Our findings suggest broadband ultrasound broadcasts may reduce bat fatalities by discouraging bats from approaching sound sources. However, effectiveness of ultrasonic deterrents is limited by distance and area ultrasound can be broadcast, in part due to rapid attenuation in humid conditions. We caution that an operational deterrent device is not yet available and further modifications and experimentation are needed. Future efforts must also evaluate cost-effectiveness of deterrents in relation to curtailment strategies to allow a cost-benefit analysis for mitigating bat fatalities. PMID:23840369

Evaluating the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at wind turbines

USGS Publications Warehouse

Arnett, Edward B.; Hein, Cris D.; Schirmacher, Michael R.; Huso, Manuela M.P.; Szewczak, Joseph M.

2013-01-01

Large numbers of bats are killed by wind turbines worldwide and minimizing fatalities is critically important to bat conservation and acceptance of wind energy development. We implemented a 2-year study testing the effectiveness of an ultrasonic acoustic deterrent for reducing bat fatalities at a wind energy facility in Pennsylvania. We randomly selected control and treatment turbines that were searched daily in summer and fall 2009 and 2010. Estimates of fatality, corrected for field biases, were compared between treatment and control turbines. In 2009, we estimated 21–51% fewer bats were killed per treatment turbine than per control turbine. In 2010, we determined an approximate 9% inherent difference between treatment and control turbines and when factored into our analysis, variation increased and between 2% more and 64% fewer bats were killed per treatment turbine relative to control turbines. We estimated twice as many hoary bats were killed per control turbine than treatment turbine, and nearly twice as many silver-haired bats in 2009. In 2010, although we estimated nearly twice as many hoary bats and nearly 4 times as many silver-haired bats killed per control turbine than at treatment turbines during the treatment period, these only represented an approximate 20% increase in fatality relative to the pre-treatment period for these species when accounting for inherent differences between turbine sets. Our findings suggest broadband ultrasound broadcasts may reduce bat fatalities by discouraging bats from approaching sound sources. However, effectiveness of ultrasonic deterrents is limited by distance and area ultrasound can be broadcast, in part due to rapid attenuation in humid conditions. We caution that an operational deterrent device is not yet available and further modifications and experimentation are needed. Future efforts must also evaluate cost-effectiveness of deterrents in relation to curtailment strategies to allow a cost-benefit analysis for mitigating bat fatalities.

Dancing the Two-Step in Ontario's Long-term Care Sector: More Deterrence-oriented Regulation = Ownership and Management Consolidation.

PubMed

Daly, Tamara

2015-03-01

This paper explores shifts in public and private delivery over time through an analysis of Ontario's approach to LTC funding and regulation in relation to other jurisdictions in Canada and abroad. The case of Ontario's long-term care (LTC) policy evolution - from the 1940s until early 2013 -- shows how moving from compliance to deterrence oriented regulation can support consolidation of commercial providers' ownership and increase the likelihood of non-profit and public providers outsourcing their management.

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 3. Spanish Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-05-16

sovereignty over the Tarfaya strip (between Western Sahara and post -colonial Morocco), over the whole of the Western Sahara and over the Spanish enclaves...veillance post , and a supply and repair vessel in the Mediterranean. Admiral of the Fleet Lewin said around the same time that the importance of Gibraltar...5.3.2 El Pais Self-appointed diario independiente de la manana. Its editorial line is controlled by Sr. Javier Pradera, former Communist Party member

Preparing for the 2009 Nuclear Posture Review: Post-Cold War Nuclear Deterrence and the 2001 NPR Debate

DTIC Science & Technology

2008-12-01

of relying upon the minimalist idea of maintaining strategic deterrence only to prevent nuclear attack.[87] Joseph Pilat agrees and tries to make...Record Straight,” The Washington Quarterly 28, no. 3 (Summer 2005): 136. 87. Payne (2005), Op. Cit., 140. 88. Pilat , Op. Cit., 43. 89. Payne (2005...152. 91. Payne (2005), Op. Cit., 142. 92. Ibid., 146. 93. Joseph F. Pilat , “The New Triad,” in Wirtz and Larson, eds., Nuclear Transformation

Deterrence and the United States Coast Guard: Enhancing Current Practice with Performance Measures

DTIC Science & Technology

2012-03-01

Talley,  Jin , Kite Powell,  The US Coast Guard Vessel Inspection Programme (2005)  Deterrence and the United States Coast Guard: Enhancing Current...practical problem-solving, not from theory or strategy. As a result, the activities are fractured and may not even be recognized as related to...of Sun Tzu’s admonition: “Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat.” The US

Interpreting labels of abuse-deterrent opioid analgesics.

PubMed

Webster, Lynn R

To provide an overview of available abuse-deterrent opioids (ADOs) and the labeling text that describes abuse-deterrent (AD) properties. A nonsystematic review of ADO literature and regulatory documents guiding their development. A critical assessment and discussion of common routes of opioid abuse, AD methods and properties, US Food and Drug Administration (FDA) study requirements to achieve AD labeling, and brief guide to understanding AD labels. The FDA has issued guidance as incentive and direction to industry to develop ADOs as one component of a multi-pronged public-health strategy to combat opioid abuse and misuse. The guidance describes separate categories of premarket and postmarket studies and makes recommendations for claims that may be made based on study findings. Ten ADOs have FDA-approved labeling attesting to AD properties. Available formulations that fail to conform to FDA guidance in study and labeling recommendations cannot be considered ADO. Formulations with AD properties are expected to reduce risk compared to the same agents without AD properties but cannot prevent all abuse and adverse clinical outcomes.

Blood donors' perceptions, motivators and deterrents in Sub-Saharan Africa - a scoping review of evidence.

PubMed

Asamoah-Akuoko, Lucy; Hassall, Oliver W; Bates, Imelda; Ullum, Henrik

2017-06-01

Achieving an adequate blood supply in Sub-Saharan Africa (SSA) through donor mobilization and retention is crucial. Factors that motivate or deter blood donors vary according to beliefs and social norms. Understanding the factors that influence blood donation behaviour in SSA is vital to developing effective strategies to address blood donor motivation and retention. This review of 35 studies from 16 SSA countries collates available evidence concerning the perceptions, motivators and deterrents that influence blood donors in SSA. The review revealed a common understanding that blood and blood donation save lives. The main deterrent to blood donation was fear due to lack of knowledge and discouraging spiritual, religious and cultural perceptions of blood donation. The main motivators for blood donation were altruism, donating blood for family and incentives. The findings support the need for targeted, culturally sensitive education, recruitment and retention strategies to improve the blood supply in SSA. © 2017 John Wiley & Sons Ltd.

Active Travel Behavior in a Border Region of Texas and New Mexico: Motivators, Deterrents, and Characteristics.

PubMed

Sener, Ipek N; Lee, Richard J

2017-08-01

Active travel has been linked with improved transportation and health outcomes, such as reduced traffic congestion and air pollution, improved mobility, accessibility, and equity, and increased physical and mental health. The purpose of this study was to better understand active travel characteristics, motivators, and deterrents in the El Paso, TX, region. A multimodal transportation survey brought together elements of transportation and health, with a focus on attitudinal characteristics. The analysis consisted of an initial descriptive analysis, spatial analysis, and multivariate binary and ordered-response models of walking and bicycling behavior. The motivators and deterrents of active travel differed for walkers, bicyclists, and noncyclists interested in bicycling. The link between active travel and life satisfaction was moderated by age, with a negative association for older travelers. This effect was stronger for bicycling than it was for walking. Based on the findings, several interventions to encourage walking and bicycling were suggested. These included infrastructure and built environment enhancements, workplace programs, and interventions targeting specific subpopulations.

Picking up the shield: Incorporating defense into strategic nuclear doctrine. Research report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruotsala, M.G.

Picking up the Shield is an interesting and enlightening account of the evolution of strategic nuclear doctrine. It puts the offense-defense relationship into a historical perspective that lends important insight into the ongoing debate over strategic defenses. Although this debate centers on the active defenses contemplated by the strategic defense initiative, Lt Col Michael G. Ruotsala makes the point that passive defenses are also an important component of strategic defense. He sees the inherent passive defenses of the Triad as being a key to maintaining offense-oriented deterrence, and he makes a good case for survivable Peacekeeper basing and a smallmore » mobile intercontinental ballistic missile (ICBM) to enhance deterrence and pave the way for active defense. Although the future may hold a strategic defense with new, even revolutionary, weapons, any future program will embody old concepts of offense and defense. For the foreseeable future, offensive strategic forces will continue to play a dominant role in US defense policy. However, strategic defenses are consistent with US strategic doctrine. More important for deterrence, defenses are consistent with Soviet doctrine. Clearly, complementing roles for both the offense and defense are critical for developing a doctrine that enhances deterrence of a nuclear exchange between the United States and the Soviet Union. It is also clear that Picking up the Shield makes a significant contribution to understanding the challenge we face as we incorporate defense into strategic nuclear doctrine.« less

West European and East Asian perspectives on defense, deterrence, and strategy. Volume 2. Western European perspectives on defense, deterrence, and strategy. Technical report, 1 December 1982-15 May 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfaltzgraff, R.L.; Davis, J.K.; Dougherty, J.E.

1984-05-16

A survey of contemporary West European perspectives on defense, deterrence, and strategy, with special emphasis on the role of nuclear weapons deployed in, or assigned to, the NATO area. Changes have occurred during the past decade in the relative military strength of NATO and the Warsaw Pact, particularly as a result of the substantial growth in Soviet nuclear-capable systems and conventional forces assigned to Europe, and the momentum manifested by the Soviet Union in its deployments of intercontinental ballistic missiles. There has also been a substantial shift in West European thinking and attitudes about security and strategy. Together, these trendsmore » have created a need to reassess the posture of NATO forces generally, and especially nuclear weapons, both in a broader Euro-strategic framework and on the Central Front in the 1980s. The survey is on such issues as the future of the British and French national strategic nuclear forces; the role of the U.S.-strategic nuclear forces in the deterrence of conflict in Europe; the prospects of raising the nuclear threshold by the deployment of new conventional technologies; the impact of strategic defense initiatives on U.S.-NATO security; and the modernization of NATO intermediate-range nuclear capabilities, especially in light of the continuing deployment of the Soviet Union of new generation Euro-strategic forces targeted against Western Europe.« less

76 FR 78775 - Investment of Customer Funds and Funds Held in an Account for Foreign Futures and Foreign Options...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

... States (U.S. government securities) and general obligations of any State or of any political subdivision... stability during the financial crisis. MF Global/Newedge, BlackRock and ADM noted that non-Fannie Mae... their mission, mitigate the systemic risk that contributed directly to instability in financial markets...

Does Lean Production Sacrifice Learning in a Manufacturing Environment? An Action Learning Case Study.

ERIC Educational Resources Information Center

Scott, Fiona M.; Butler, Jim; Edwards, John

2001-01-01

An action learning program was implemented by a manufacturer using lean production practices. Action learning practices were accommodated during times of stability, but abandoned in times of crisis. The meaning of work in this organizational culture excluded all practices, such as reflection, that were not visible and targeted at immediate…

The Lender’s Mercy

DTIC Science & Technology

2012-04-01

to utilize government spending in an attempt to stabilize banks , individuals, and corporations . Unfortunately, even before the crisis, government...DISTRIBUTION A. Approved for public release: Distribution unlimited Disclaimer The views expressed in this academic research paper are...as the world’s largest debtor, the United States, is positioning itself in a similarly precarious position. This paper seeks to explore how the

Counterinsurgency After Afghanistan: A Concept in Crisis

DTIC Science & Technology

2011-12-01

in strategy was undeniably stabilizing. This also explains the concrete walls, barriers, check- points, and other population-control measures...partnering with Sunni community leaders, Dagger Brigade was able to interpose itself—with concrete barriers, combined outposts, and checkpoints...local forces work together toward the same end. Also important in this regard are the aforementioned check- points, concrete barriers, and other

Dancing the Two-Step in Ontario’s Long-term Care Sector: More Deterrence-oriented Regulation = Ownership and Management Consolidation

PubMed Central

Daly, Tamara

2016-01-01

This paper explores shifts in public and private delivery over time through an analysis of Ontario’s approach to LTC funding and regulation in relation to other jurisdictions in Canada and abroad. The case of Ontario’s long-term care (LTC) policy evolution – from the 1940s until early 2013 -- shows how moving from compliance to deterrence oriented regulation can support consolidation of commercial providers’ ownership and increase the likelihood of non-profit and public providers outsourcing their management. PMID:27777495

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 4. Portuguese Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-05-16

in U.S. military planning , the West has to face growing threats in the peripheral zones, namely in those that are essential to the supply of raw...to a re-definition of U.S. strategic planning . In accordance with the ’Maritime strategy" of deployment from the U.S. territory of important military...Socialist Party, and the editor of the Communist daily, O’Diario, Miguel Urbano Rodriques. Neutralist doctrines are abundantly expressed in Liber 25

Nothing New Under the Sun: Benefiting from the Great Lessons of History to Develop a Coherent Cyberspace Deterrence Strategy

DTIC Science & Technology

2012-05-12

LESSONS OF HISTORY TO DEVELOP A COHERENT CYBERSPACE DETERRENCE STRATEGY 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHDR!SI 5d. PROJECT ...AFOSR-82-1234. 5c. PROGRAM ELEMENT NUMBER. Enter all program element numbers as they appear in the report, e.g. 61101 A. 5d. PROJECT NUMBER...Enter all project numbers as they appear in the report, e.g. 1F665702D1257; ILIR. 5e. TASK NUMBER. Enter all task numbers as they appear in the

Biosynthesis and Regulation of Bioprotective Alkaloids in the Gramineae Endophytic Fungi with Implications for Herbivores Deterrents.

PubMed

Luo, Hongping; Xie, Longxiang; Zeng, Jie; Xie, Jianping

2015-12-01

Four kinds of bioprotective alkaloids-peramine, loline, ergot alkaloid, indole-diterpenes, produced by grass-fungal endophyte symbioses, are deterrents or toxic to vertebrate and invertebrate herbivores. Ergot alkaloids have pharmacological properties and widely are used clinically. The regulation of alkaloids biosynthesis is under intensive study to improve the yield for better agricultural and medicinal application. In this paper, we summarize the structure, related genes, regulation, and toxicity of alkaloids. We focus on the biosynthesis and the regulation network of alkaloids.

Are international securitized property markets converging or diverging?

NASA Astrophysics Data System (ADS)

Hui, Eddie C. M.; Chen, Jia; Chan, Ka Kwan Kevin

2016-03-01

This study establishes a new framework which combines the recursive model with the Fractionally Integrated Vector Error Correction Model (FIVECM) to investigate the cointegration relationship among 9 securitized real estate indices, which are divided into three groups: Asian, European and North American groups. Our new combined framework has the advantage of reflecting the changes in cointegration dynamics over a period of time instead of a single result for the whole period. The results show that the three groups of markets follow a similar cointegration trend: the cointegration relationship gradually increases before the global financial crisis, reaches a peak during the crisis, and dies down gradually after the crisis. However, cointegration among Asian and European countries occurs at a much later time than cointegration among North American countries does, showing that North America is the source of cointegration, while Asia and Europe are the recipients. This study has important implications to investors and related authorities that investors can adjust their portfolio according to the test results to reduce their risk, while related authorities can take appropriate measures to stabilize the economy and mitigate the effects of financial crises.

Bereavement and spiritual change.

PubMed

Balk, D E

1999-09-01

The thesis of this article is that bereavement is a life crisis that challenges one's assumptions about human existence and provides the grounds for spiritual change. Construing a new understanding of the meaning of human existence and revising assumptions about one's place in the universe is a singular form that indicates spiritual change at work. Three aspects must be present for a life crisis to produce spiritual change: The situation must create a psychological imbalance or disequilibrium that resists readily being stabilized; there must be time for reflection; and the person's life must forever afterwards be colored by the crisis. The premise of this article links spiritual change to what J.W. Fowler (1981) termed transformed faith consciousness and argues that the dual process model of coping with loss (M.S. Stroebe & H. Schut, 1995; M.S. Stroebe, H. Schut, & W.A. Stroebe, 1995; M.S. Stroebe, H. Schut, & J. Van Den Bout, 1994) provides a means to understand how dealing with grief can evoke spiritual change. Some brief case examples are used to examine the thesis that bereavement triggers spiritual change.

The global financial crisis and the Great Recession of 2007-2009.

PubMed

Dore, Mohammed H I; Singh, Rajiv G

2010-07-01

This paper is a re-examination of the global financial crisis that began in and was accompanied by the most severe recession since the Great Depression. It builds on our earlier paper (Dore and Singh, 2009) and expands its scope. It is divided into parts. The first part deals with the ideological backdrop in which this crisis occurred, namely the belief in the rationality and stability of all markets including the capital markets, called the 'efficient market hypothesis.' The second part is a survey of the role of income distribution and its relations to aggregate spending and the growing role played by credit in the circular flow of income. The third part examines some features of the business cycle expansion phase of to . The fourth part is a brief report on a nonlinear Vector Error Correction model spanning the period to and how this expansion came to an end. The fifth part is a brief comparison of the Great Recession with the Great Depression. Finally in the sixth part, the international impact of the Great Recession is considered briefly, followed by some conclusions.

Challenges Involved in the Development and Delivery of Abuse-deterrent Formulations of Opioid Analgesics.

PubMed

Cohen, Joshua P; Mendoza, Mario; Roland, Carl

2018-02-01

This commentary examines the development, regulatory, and reimbursement challenges facing abuse-deterrent formulation (ADF) products. In January 2017, the Tufts Center for the Study of Drug Development convened a roundtable to explore clinical development, regulatory, and reimbursement challenges with respect to ADFs of opioid analgesics. Roundtable participants, who included a range of pharmaceutical industry and other experts, discussed multiple challenges. First, several key clinical development challenges were identified and discussed. These challenges pertain to prodrug development and development of deterrents against oral abuse. Second, experts suggested that more clarity is needed from regulatory authorities regarding standards for proving ADF labeling claims and for being rewarded with 3-year data exclusivity. Similarly, given the substantial burdens associated with the development of postapproval evidence generation, experts raised the need for a consistent regulatory policy related to postapproval evidence generation for all ADFs (branded and generic). Third, despite the public health benefits of certain ADF products, current coverage and access policies impede patient access. Payer justification for restrictive policies appears to be based more on budget impact considerations than cost-effectiveness. Fourth, there remains a need to further expand the evidence base regarding clinical and cost-effectiveness as well as abuse deterrence in a real-world setting for all ADF products. Clinical development challenges need to be overcome with respect to novel ADF technologies, such as prodrugs and deterrents against oral abuse. More clarity is needed from regulatory authorities on labeling claims and data exclusivity eligibility with respect to ADFs. Ensuring prescriber training and awareness of various options for treating pain, including ADF products, is an important step, as is educating payers about the public health benefits of ADFs in appropriate subpopulations of pain patients. In addition, physicians may need to incorporate appropriate risk stratification methods. Finally, it is important to establish a level playing field between coverage of ADF and non-ADF products so that non-ADF products are not given preferred formulary placement. Copyright © 2018 Elsevier HS Journals, Inc. All rights reserved.

Testing the effectiveness of an acoustic deterrent for gray whales along the Oregon coast

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lagerquist, Barbara; Winsor, Martha; Mate, Bruce

This study was conducted to determine whether a low-powered sound source could be effective at deterring gray whales from areas that may prove harmful to them. With increased interest in the development of marine renewal energy along the Oregon coast the concern that such development may pose a collision or entanglement risk for gray whales. A successful acoustic deterrent could act as a mitigation tool to prevent harm to whales from such risks. In this study, an acoustic device was moored on the seafloor in the pathway of migrating gray whales off Yaquina Head on the central Oregon coast. Shore-basedmore » observers tracked whales with a theodolite (surveyor’s tool) to accurately locate whales as they passed the headland. Individual locations of different whales/whale groups as well as tracklines of the same whale/whale groups were obtained and compared between times with the acoustic device was transmitting and when it was off. Observations were conducted on 51 d between January 1 and April 15, 2012. A total of 143 individual whale locations were collected for a total of 243 whales, as well as 57 tracklines for a total of 142 whales. Inclement weather and equipment problems resulted in very small sample sizes, especially during experimental periods, when the device was transmitting. Because of this, the results of this study were inconclusive. We feel that another season of field testing is warranted to successfully test the effectiveness of the deterrent, but recommend increasing the zone of influence to 3 km to ensure the collection of adequate sample sizes. Steps have been taken to acquire the necessary federal research permit modification to authorize the increased zone of influence and to modify the acoustic device for the increased power. With these changes we are confident we will be able to determine whether the deterrent is effective at deflecting gray whales. A successful deterrent device may serve as a valuable mitigation tool to protect gray whales, and other baleen whales, in the event that marine energy development poses a collision or entanglement risk.« less

Universities in Africa: Strategies for Stabilization and Revitalization. World Bank Technical Paper No. 194, Africa Technical Department Series.

ERIC Educational Resources Information Center

Saint, William S.

This publication presents the results of a study on how to overcome the current crisis of quality, relevance and finance in African universities. The analysis developed from the 1988 policy study, "Education in Sub-Saharan Africa," and discussion within the Donors to African Education Working Group on Higher Education. In 12 chapters the…

Commemoration in crisis: A discursive analysis of who 'we' and 'they' have been or become in ceremonial political speeches before and during the Greek financial downturn.

PubMed

Gkinopoulos, Theofilos; Hegarty, Peter

2018-02-17

This study analyses the discourse of statements of the leaders of two Greek political parties commemorating the restoration of Greek democracy on 24 July 1974; the ruling party New Democracy and the opposition, Coalition of the Radical Left. We focus on how these leaders act as entrepreneurs of their identities by constructing their ingroups in broad or narrow terms and their outgroups in vague or specific terms. These constructions were ventured during a period of relative political stability (2008) and instability (2012), and we focus on how ingroup prototypes and group boundaries are narrated across Greece's past, present and future in ambiguous or concrete terms. The study aligns the social identity approach to political leadership with studies on political discourse and 'the rhetoric of we'. We view commemorative statements as historical charters and respond to calls for discourse analysis to take greater account of historical context. The findings suggest concrete hypotheses about how leaders with different amounts of political support might define, as identity entrepreneurs, who 'we' are, and who 'we' are not in democratic contexts marked by stability or crisis. © 2018 The British Psychological Society.

Evaluation of the Activity of the Essential Oil from an Ornamental Flower against Aedes aegypti: Electrophysiology, Molecular Dynamics and Behavioral Assays.

PubMed

Bezerra-Silva, Patrícia C; Dutra, Kamilla A; Santos, Geanne K N; Silva, Rayane C S; Iulek, Jorge; Milet-Pinheiro, Paulo; Navarro, Daniela M A F

2016-01-01

Dengue fever has spread worldwide and affects millions of people every year in tropical and subtropical regions of Africa, Asia, Europe and America. Since there is no effective vaccine against the dengue virus, prevention of disease transmission depends entirely on regulating the vector (Aedes aegypti) or interrupting human-vector contact. The aim of this study was to assess the oviposition deterrent activity of essential oils of three cultivars of torch ginger (Etlingera elatior, Zingiberaceae) against the dengue mosquito. Analysis of the oils by gas chromatography (GC)-mass spectrometry revealed the presence of 43 constituents, of which α-pinene, dodecanal and n-dodecanol were the major components in all cultivars. Solutions containing 100 ppm of the oils exhibited oviposition deterrent activities against gravid Ae. aegypti females. GC analysis with electroantennographic detection indicated that the oil constituents n-decanol, 2-undecanone, undecanal, dodecanal, trans-caryophyllene, (E)-β-farnesene, α-humulene, n-dodecanol, isodaucene and dodecanoic acid were able to trigger antennal depolarization in Ae. aegypti females. Bioassays confirmed that solutions containing 50 ppm of n-dodecanol or dodecanal exhibited oviposition deterrent activities, while a solution containing the alcohol and aldehyde in admixture at concentrations representative of the oil presented an activity similar to that of the 100 ppm oil solution. Docking and molecular dynamics simulations verified that the interaction energies of the long-chain oil components and Ae. aegypti odorant binding protein 1 were quite favorable, indicating that the protein is a possible oviposition deterrent receptor in the antenna of Ae. aegypti.

Testing and Contrasting Road Safety Education, Deterrence, and Social Capital Theories: A Sociological Approach to the Understanding of Male Drink-Driving in Chile's Metropolitan Region.

PubMed

Nazif, José Ignacio

2011-01-01

Three theories offer different explanations to the understanding of male drink-driving. In order to test road safety education, deterrence, and social capital theories, logistic regression analysis was applied to predict respondents' statements of having or not having engaged in actual drink-driving (DD). Variable for road safety education theory was whether a driver had graduated from a professional driving school or not. Deterrence theory was operationalized with a variable of whether a driver had been issued a traffic ticket or not. Social capital theory was operationalized with two variables, having children or not and having religion identification or not. Since both variables 'years of formal education' and 'years of driving experience' have been reported to be correlated to alcohol consumption and DD respectively, these were introduced as controls. In order to assess the significance of each variable statistically, Wald tests were applied in seven models. Results indicate on the one hand that road safety education variable is not statistically significant; and on the other, deterrence theory variable and social capital theory variable 'having children' were both statistically significant at the level of .01. Findings are discussed in reference to Chile's context. Data were taken from the "Road Users Attitudes and Behaviors towards Traffic Safety" survey from the National Commission of Road Safety of the Government of Chile (2005). The sample size was reported to be 2,118 (N of male drivers was 396). This survey was representative of Chile's Metropolitan Region road users' population.

Systematic review of the prevention incentives of insurance and regulatory mechanisms for occupational health and safety.

PubMed

Tompa, Emile; Trevithick, Scott; McLeod, Chris

2007-04-01

The objective of this study was to determine the strength of evidence on the effectiveness of two policy levers-the experience rating of workers' compensation insurance and the enforcement of occupational health and safety regulation-in creating incentives for firms to focus on health and safety issues. An extensive systematic literature review was undertaken in an effort to capture both published and grey literature studies on the topic. Studies that met specific subject-matter and methods criteria underwent a quality assessment. A qualitative approach to evidence synthesis, known as "best-evidence" synthesis, was used. This method ranks the strength of evidence on a particular topic on the basis of the number, quality, and consistency of studies on the topic. There was moderate evidence that the degree of experience rating reduces injuries, limited to mixed evidence that inspections offer general and specific deterrence and that citations and penalties aid general deterrence, and strong evidence that actual citations and penalties reduce injuries. Although experience rating is a key policy lever of those providing workers' compensation insurance, there is much to be learned about its merits. Few studies have concerned the topic, and most have used crude proxy measures or exploited natural experiments. There have been many more studies on the merits of regulation enforcement, even though here too measures were often crude. Nonetheless, this synthesis indicates that general deterrence is less effective in reducing injury incidence and severity, whereas specific deterrence with regard to citations and penalties does indeed have an impact.

Evaluating the abuse potential of opioids and abuse-deterrent -opioid formulations: A review of clinical study methodology.

PubMed

Setnik, Beatrice; Schoedel, Kerri A; Levy-Cooperman, Naama; Shram, Megan; Pixton, Glenn C; Roland, Carl L

With the development of opioid abuse-deterrent formulations (ADFs), there is a need to conduct well-designed human abuse potential studies to evaluate the effectiveness of their deterrent properties. Although these types of studies have been conducted for many years, largely to evaluate inherent abuse potential of a molecule and inform drug scheduling, methodological approaches have varied across studies. The focus of this review is to describe current "best practices" and methodological adaptations required to assess abuse-deterrent opioid formulations for regulatory submissions. A literature search was conducted in PubMed® to review methodological approaches (study conduct and analysis) used in opioid human abuse potential studies. Search terms included a combination of "opioid," "opiate," "abuse potential," "abuse liability," "liking," AND "pharmacodynamic," and only studies that evaluated single doses of opioids in healthy, nondependent individuals with or without prior opioid experience were included. Seventy-one human abuse potential studies meeting the prespecified criteria were identified, of which 21 studies evaluated a purported opioid ADF. Based on these studies, key methodological considerations were reviewed and summarized according to participant demographics, study prequalification, comparator and dose selection, route of administration and drug manipulation, study blinding, outcome measures and training, safety, and statistical analyses. The authors recommend careful consideration of key elements (eg, a standardized definition of a "nondependent recreational user"), as applicable, and offer key principles and "best practices" when conducting human abuse potential studies for opioid ADFs. Careful selection of appropriate study conditions is dependent on the type of ADF technology being evaluated.

Rats and seabirds: effects of egg size on predation risk and the potential of conditioned taste aversion as a mitigation method.

PubMed

Latorre, Lucía; Larrinaga, Asier R; Santamaría, Luis

2013-01-01

Seabirds nesting on islands are threatened by invasive rodents, such as mice and rats, which may attack eggs, chicks and even adults. The low feasibility of rat eradications on many islands makes the development of alternate control plans necessary. We used a combination of field experiments on a Mediterranean island invaded by black rats (Rattusrattus) to evaluate (1) the predation risk posed to different-sized seabird eggs and (2), the potential of two deterrent methods (electronic and chemical) to reduce its impact. Rats were able to consume eggs of all sizes (12 to 68 g), but survival increased 13 times from the smallest to the largest eggs (which also had more resistant eggshells). Extrapolation to seabird eggs suggests that the smallest species (Hydrobatespelagicus) suffer the most severe predation risk, but even the largest (Larusmichahellis) could suffer >60% mortality. Nest attack was not reduced by the deterrents. However, chemical deterrence (conditioned taste aversion by lithium chloride) slowed the increase in predation rate over time, which resulted in a three-fold increase in egg survival to predation as compared to both control and electronic deterrence. At the end of the experimental period, this effect was confirmed by a treatment swap, which showed that conferred protection remains at least 15 days after cessation of the treatment. Results indicate that small seabird species are likely to suffer severe rates of nest predation by rats and that conditioned taste aversion, but not electronic repellents, may represent a suitable method to protect colonies when eradication or control is not feasible or cost-effective.

Testing and Contrasting Road Safety Education, Deterrence, and Social Capital Theories: A Sociological Approach to the Understanding of Male Drink-Driving in Chile’s Metropolitan Region

PubMed Central

Nazif, José Ignacio

2011-01-01

Three theories offer different explanations to the understanding of male drink-driving. In order to test road safety education, deterrence, and social capital theories, logistic regression analysis was applied to predict respondents’ statements of having or not having engaged in actual drink-driving (DD). Variable for road safety education theory was whether a driver had graduated from a professional driving school or not. Deterrence theory was operationalized with a variable of whether a driver had been issued a traffic ticket or not. Social capital theory was operationalized with two variables, having children or not and having religion identification or not. Since both variables ‘years of formal education’ and ‘years of driving experience’ have been reported to be correlated to alcohol consumption and DD respectively, these were introduced as controls. In order to assess the significance of each variable statistically, Wald tests were applied in seven models. Results indicate on the one hand that road safety education variable is not statistically significant; and on the other, deterrence theory variable and social capital theory variable ‘having children’ were both statistically significant at the level of .01. Findings are discussed in reference to Chile’s context. Data were taken from the “Road Users Attitudes and Behaviors towards Traffic Safety” survey from the National Commission of Road Safety of the Government of Chile (2005). The sample size was reported to be 2,118 (N of male drivers was 396). This survey was representative of Chile’s Metropolitan Region road users' population. PMID:22105406

Symbiotic Dinoflagellate Functional Diversity Mediates Coral Survival under Ecological Crisis.

PubMed

Suggett, David J; Warner, Mark E; Leggat, William

2017-10-01

Coral reefs have entered an era of 'ecological crisis' as climate change drives catastrophic reef loss worldwide. Coral growth and stress susceptibility are regulated by their endosymbiotic dinoflagellates (genus Symbiodinium). The phylogenetic diversity of Symbiodinium frequently corresponds to patterns of coral health and survival, but knowledge of functional diversity is ultimately necessary to reconcile broader ecological success over space and time. We explore here functional traits underpinning the complex biology of Symbiodinium that spans free-living algae to coral endosymbionts. In doing so we propose a mechanistic framework integrating the primary traits of resource acquisition and utilisation as a means to explain Symbiodinium functional diversity and to resolve the role of Symbiodinium in driving the stability of coral reefs under an uncertain future. Copyright © 2017 Elsevier Ltd. All rights reserved.

Electrophysiological Responses of Gustatory Receptor Neurons on the Labella of the Common Malaria Mosquito, Anopheles quadrimaculatus (Diptera: Culicidae).

PubMed

Sparks, Jackson T; Dickens, Joseph C

2016-05-11

We recorded electrical responses from sensory cells associated with gustatory sensilla on the labella of female Anopheles quadrimaculatus Say to salt, sucrose, quinine (a feeding deterrent), and the insect repellent, N,N-diethyl-3-methylbenzamide (DEET). A salt-sensitive cell responded to increasing concentrations of sodium chloride. A second cell was activated by increasing sucrose concentrations, while quinine, DEET, or a mixture of quinine + DEET elicited spike activity from a third cell, an apparent bitter- or deterrent-sensitive cell. Both quinine and DEET suppressed activity of the sugar-sensitive cell; sucrose suppressed activity of the bitter- or deterrent-sensitive cell. These results demonstrate separate gustatory pathways for a feeding stimulant and aversive contact cues mediated through distinct sensory inputs on the labellum. This sensory appendage may serve as a useful target to disrupt feeding behavior in this and other anopheline species, which transmit diseases like malaria to human populations. Published by Oxford University Press on behalf of Entomological Society of America 2016. This work is written by US Government employees and is in the public domain in the United States.

Can Nuclear Terrorists be Deterred?

NASA Astrophysics Data System (ADS)

Ferguson, Charles

2005-04-01

Conventional thinking since September 11, 2001, posits that nuclear-armed terrorists cannot be deterred. However, not all terrorist groups are alike. For instance, those that are strongly affiliated with a national territory or a constituency that can be held hostage are more likely to be self-deterred against using or even acquiring nuclear weapons. In contrast, international terrorist organizations, such as al Qaeda, or apocalyptic groups, such as Aum Shinrikyo, may welcome retaliatory nuclear strikes because they embrace martyrdom. Such groups may be immune to traditional deterrence, which threatens direct punishment against the group in question or against territory or people the terrorists' value. Although deterring these groups may appear hopeless, nuclear forensic techniques could provide the means to establish deterrence through other means. In particular, as long as the source of the nuclear weapon or fissile material could be identified, the United States could threaten a retaliatory response against a nation that did not provide adequate security for its nuclear weapons or weapons-usable fissile material. This type of deterrent threat could be used to compel the nation with lax security to improve its security to meet rigorous standards.

United States initiative for chemical weapons arms control. Master`s thesis, 2 August 1995-7 June 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, R.D.

1996-06-07

This research investigates the US policy initiative renouncing the employment of chemical weapons (CW). The focus of the research is to determine if such an initiative will achieve the national objective for implementation of the Chemical Weapons Convention (CWC). If the initiative does not meet the national objective are there feasible options for the United States Government (USG). In 1993, the USG established a policy banning the use of chemical weapons. This act may have won the battle for the moral high ground, but it will not deter nor eliminate the use of chemical weapons worldwide. The relative ease bymore » which a nation can take various combinations of chemical compounds and produce a lethal chemical agent makes deterrence and/or complete elimination virtually impossible. The US should continue to employ the elements of diplomatic, informational, military, and economic policy regarding nonproliferation inclusive of a proven deterrent-CW. No use of CW or any weapon of mass destruction is best, but until the CWC is ratified a deterrent should be maintained by the US.« less

On sanction-goal justifications: How and why deterrence justifications undermine rule compliance.

PubMed

Mooijman, Marlon; van Dijk, Wilco W; van Dijk, Eric; Ellemers, Naomi

2017-04-01

Authorities frequently justify their sanctions as attempts to deter people from rule breaking. Although providing a sanction justification seems appealing and harmless, we propose that a deterrence justification decreases the extent to which sanctions are effective in promoting rule compliance. We develop a theoretical model that specifies how and why this occurs. Consistent with our model, 5 experiments demonstrated that-compared with sanctions provided without a justification or sanctions provided with a just-deserts justification-sanction effectiveness decreased when sanctions were justified as attempts to deter people from rule breaking. This effect was mediated by people feeling distrusted by the authority. We further demonstrated that (a) the degree to which deterrence fostered distrust was attenuated when the sanction was targeted at others (instead of the participant) and (b) the degree to which distrust undermined rule compliance was attenuated when the authority was perceived as legitimate. We discuss the practical implications for authorities tasked with promoting rule compliance, and the theoretical implications for the literature on sanctions, distrust, and rule compliance. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

The effects of picric acid (2,4,6-trinitrophenol) and a bite-deterrent chemical (denatonium benzoate) on autotomy in rats after peripheral nerve lesion.

PubMed

Firouzi, Matin Sadat; Firouzi, Masoumeh; Nabian, Mohammad Hossein; Zanjani, Leila Oryadi; Zadegan, Shayan Abdollah; Kamrani, Reza Shahryar; Rahimi-Movaghar, Vafa

2015-04-01

Denervation of the hind limb is a technique used to study peripheral nerve regeneration. Autotomy or autophagia is an undesirable response to denervation in such studies. Application of a commercially available lotion used to deter nail biting in humans reduced autotomy in rats after denervation but did not completely prevent it. In this study, this authors evaluated the application of picric acid to prevent autotomy in rats in peripheral nerve experiments. They carried out sciatic nerve transection in 41 adult female Wistar rats and then applied either bite-deterrent lotion (n = 26) or saturated picric acid solution (n = 15) topically to the affected hind limb immediately after surgery and every day for 1 month. Autotomy scores were lower for rats treated with picric acid than for rats treated with bite-deterrent lotion 1 week and 2 weeks after surgery but were not different between the two groups 4 weeks after surgery. The authors conclude that application of picric acid could be used as an alternative strategy to prevent autotomy in peripheral nerve studies.

Biodiversity and ecosystem stability across scales in metacommunities

PubMed Central

Wang, Shaopeng; Loreau, Michel

2016-01-01

Although diversity-stability relationships have been extensively studied in local ecosystems, the global biodiversity crisis calls for an improved understanding of these relationships in a spatial context. Here we use a dynamical model of competitive metacommunities to study the relationships between species diversity and ecosystem variability across scales. We derive analytic relationships under a limiting case; these results are extended to more general cases with numerical simulations. Our model shows that, while alpha diversity decreases local ecosystem variability, beta diversity generally contributes to increasing spatial asynchrony among local ecosystems. Consequently, both alpha and beta diversity provide stabilizing effects for regional ecosystems, through local and spatial insurance effects, respectively. We further show that at the regional scale, the stabilizing effect of biodiversity increases as spatial environmental correlation increases. Our findings have important implications for understanding the interactive effects of global environmental changes (e.g. environmental homogenization) and biodiversity loss on ecosystem sustainability at large scales. PMID:26918536

The Canadian Natural Health Products (NHP) Regulations: Industry Compliance Motivations

PubMed Central

Laeeque, Hina; Kachan, Natasha; Cohen, Jillian Clare; D'Cruz, Joseph

2007-01-01

This qualitative study explores corporations' motivations to comply with new natural health products (NHP) Regulations in Canada. Interviews were conducted with representatives from 20 Canadian NHP companies. Findings show that the rationale for compliance differs for large compared to small and medium-sized enterprises (SMEs). Large firms are motivated to comply with the regulations because of the deterrent fear of negative media coverage, social motivations, ability to comply and maintaining a competitive market advantage. In contrast, SMEs are motivated to comply due to the deterrent fear of legal prosecution and a sense of duty. PMID:17549245

An overview of the potential threat as related to missile requirements

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1983-01-01

Based on unclassified sources, a general review is presented of the perceived U.S.S.R. doctrine, force balances, production ratios, inventory growth, inventory items, and current actions. The extent to which the Soviets appear to be attempting to increase their sphere of influence through economic and political control as well as possible military control of land, sea, air, and space is considered. To offset such possibilities, certain areas of deterrent needs that the Western world might pursue are suggested. Particular emphasis is placed on the role of missiles as part of the deterrent needs.

Antifeedant activity of xanthohumol and supercritical carbon dioxide extract of spent hops against stored product pests.

PubMed

Jackowski, J; Hurej, M; Rój, E; Popłoński, J; Kośny, L; Huszcza, E

2015-08-01

Xanthohumol, a prenylated flavonoid from hops, and a supercritical carbon dioxide extract of spent hops were studied for their antifeedant activity against stored product insect pests: Sitophilus granarius L., Tribolium confusum Duv. and Trogoderma granarium Everts. Xanthohumol exhibited medium deterrent activity against the adults of S. granarius L. and larvae of T. confusum Duv. The spent hops extract was more active than xanthohumol towards the adults of T. confusum Duv. The potential application of the crude spent hops extract as a feeding deterrent against the stored product pests is proposed.

The Canadian Natural Health Products (NHP) regulations: industry compliance motivations.

PubMed

Laeeque, Hina; Boon, Heather; Kachan, Natasha; Cohen, Jillian Clare; D'Cruz, Joseph

2007-06-01

This qualitative study explores corporations' motivations to comply with new natural health products (NHP) Regulations in Canada. Interviews were conducted with representatives from 20 Canadian NHP companies. Findings show that the rationale for compliance differs for large compared to small and medium-sized enterprises (SMEs). Large firms are motivated to comply with the regulations because of the deterrent fear of negative media coverage, social motivations, ability to comply and maintaining a competitive market advantage. In contrast, SMEs are motivated to comply due to the deterrent fear of legal prosecution and a sense of duty.

Remixing the ‘Appropriate Mix’: Reassessing NATO’s Deterrence and Defense Posture in the Face of New Threats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juarez, Anthony

The North Atlantic Treaty Organization (NATO) and the countries of Europe face a renewed challenge from the east vis-à-vis the Putin regime in Moscow. In the face of these new challenges, NATO must reconsider its deterrence and defense posture in order to deter conflict in Europe. Unfortunately, Russian attempts to rewrite the rules of the post-Cold War international order by force have been coupled with nuclear saber rattling and overt nuclear threats. Russia’s nuclear threats, in addition to provocative changes to Russia’s nuclear posture in its Military Doctrine, are methods to make up for Russia’s conventional military inferiority relative tomore » NATO and the United States. Some have described Moscow’s actions as laying the groundwork for a nuclear coercion strategy. While the decrease in the nuclear arsenals of Russia and the United States has reduced the likelihood of nuclear annihilation to an all-time low since the height of the Cold War, Russia’s nuclear coercion strategy is increasing the probability of nuclear employment in Europe. The probability of nuclear use is compounded by Russia’s tremendous local military advantage around its periphery in spite of U.S. global military primacy. This military advantage increases the incentive to use military force if Russian decision-makers conclude that a quick military victory is possible, or if Russian leaders miscalculate based on an incorrect assessment of military force balance or resolve of their adversary. The integration of Lithuania, Latvia, and Estonia (referred to as the Baltics in this paper) into the NATO alliance in 2004 makes Russia’s military advantage in its periphery increasingly relevant. Each NATO state is required to assist any NATO state that comes under attack per Article V of the North Atlantic Treaty. The Baltic states’ proximity to Russia, their weak indigenous militaries, their former status as Soviet Republics, large population of ethnic Russians, and Russian President Vladimir V. Putin’s claim that he will protect Russians wherever they are makes the Baltics the most likely flashpoint for conflict between NATO and Russia. This analysis will tackle the problem of reshaping NATO’s deterrence and defense posture in light of the new Russian threat and its obligation to defend its most vulnerable members. Specifically, it will assess the suitability of NATO’s “appropriate mix” of nuclear, conventional, and missile defense capabilities to deterring conventional conflict with Russia and, if conventional deterrence fails, preventing Russian nuclear escalation. It will use a scenario-based approach informed by a deterrence model to explore how changes to NATO’s posture and policy could impact the deterrence of Russian aggression.« less

Mutant IDH1 expression drives TERT promoter reactivation as part of the cellular transformation process

PubMed Central

Ohba, Shigeo; Mukherjee, Joydeep; Johannessen, Tor-Christian; Mancini, Andrew; Chow, Tracy T.; Wood, Matthew; Jones, Lindsey; Mazor, Tali; Marshall, Roxanne E.; Viswanath, Pavithra; Walsh, Kyle M.; Perry, Arie; Bell, Robert J. A.; Phillips, Joanna J.; Costello, Joseph F.; Ronen, Sabrina M.; Pieper, Russell O.

2016-01-01

Mutations in the isocitrate dehydrogenase gene IDH1 are common in lower-grade glioma where they result in the production of 2-hydroxyglutarate (2HG), disrupted patterns of histone methylation and gliomagenesis. IDH1 mutations also co-segregate with mutations in the ATRX gene and the TERT promoter, suggesting that IDH mutation may drive the creation or selection of telomere-stabilizing events as part of immortalization/transformation process. To determine if and how this may occur, we investigated the phenotype of pRb/p53-deficient human astrocytes engineered with IDH1 wild-type (WT) or R132H mutant (IDH1mut) genes as they progressed through their lifespan. IDH1mut expression promoted 2HG production and altered histone methylation within 20 population doublings (PD), but had no effect on telomerase expression or telomere length. Accordingly, cells expressing either IDH1 WT or IDH1mut entered a telomere-induced crisis at PD 70. In contrast, only IDH1mut cells emerged from crisis, grew indefinitely in culture and formed colonies in soft agar and tumors in vivo. Clonal populations of post-crisis IDH1mut cells displayed shared genetic alterations, but no mutations in ATRX or the TERT promoter were detected. Instead, these cells reactivated telomerase and stabilized their telomeres in association with increased histone lysine methylation (H3K4me3) and c-Myc/Max binding at the TERT promoter. Overall, these results show that while IDH1mut does not create or select for ATRX or TERT promoter mutations, it can indirectly reactivate TERT, and in doing so contribute to astrocytic immortalization and transformation. PMID:27758882

Celiac Crisis: A Rare Or Rarely Recognized Disease.

PubMed

Waheed, Nadia; Cheema, Huma Arshad; Suleman, Hassan; Fayyaz, Zafar; Mushtaq, Iqra; Muhammad; Hashmi, Almas

2016-01-01

Celiac crisis is a serious life threatening complication of celiac disease characterized by profuse diarrhoea, severe dehydration and metabolic disturbances leading to neuromuscular weakness, cardiac arrhythmias and sudden death. It has been described as rare condition and not well documented in the literature. To improve awareness and facilitate diagnosis of this condition, we studied risk factors, pattern of presentation and management plans of celiac crisis. It was a descriptive cross sectional study. Patients presenting in emergency room(ER) with profuse diarrhoea leading to severe dehydration, neuromuscular weakness, and metabolic acidosis and electrolyte abnormalities enrolled in the studies after positive serology and small bowel biopsy suggestive of celiac disease. Total 126 patients out of 350 fulfilled the criteria including 54 (42.8%) male and 71 (56.3%) female. The mean age at presentation was 5.25±1.18 years. Risk factors were poor social status (97.60%), consanguinity (96.77%), early weaning with gluten contained diet (93.54%), and Presenting complaints were loose motion (100%), loss of neck holding (96.77%), dehydration (96.77%), polyuria (95.96%), inability to walk (67.74%), abdominal distension (85.86%). Electrolytes imbalances were hypokalaemia (2.4±0.55), hypocalcaemia (7.29±0.66), hypomagnesaemia (1.89±0.50), hypophosphatemia (2.8±0.68), hypoalbuminemia (3.05±0.48) and metabolic acidosis (96%). One hundred & twenty patients were stabilized with GFD and correction of dehydration, acidosis and electrolyte imbalance. Six patients needed parenteral steroids ant total parenteral nutrition (TPN). Recovery time from crisis was mean 5.4±2.73 days (range 3-20 days). Celiac crisis is a common but under recognized problem in developing countries. Commonest presenting feature is neuromuscular paralysis and biochemical abnormality is hypokalaemia.

REDUCTIONS WITHOUT REGRET: DEFINING THE NEEDED CAPABILITIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swegle, J.; Tincher, D.

This is the second of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as somemore » closing thoughts for the future. This paper begins with a discussion of the current nuclear force and the plans and procurement programs for the modernization of that force. Current weapon systems and warheads were conceived and built decades ago, and procurement programs have begun for the modernization or replacement of major elements of the nuclear force: the heavy bomber, the air-launched cruise missile, the ICBMs, and the ballistic-missile submarines. In addition, the Nuclear Weapons Council has approved a new framework for nuclear-warhead life extension not fully fleshed out yet that aims to reduce the current number of nuclear explosives from seven to five, the so-called 3+2 vision. This vision includes three interoperable warheads for both ICBMs and SLBMs (thus eliminating one backup weapon) and two warheads for aircraft delivery (one gravity bomb and one cruise-missile, eliminating a second backup gravity bomb). This paper also includes a discussion of the current and near-term nuclear-deterrence mission, both global and regional, and offers some observations on future of the strategic deterrence mission and the challenges of regional and extended nuclear deterrence.« less

Production, perceptions, and punishment: restrictive deterrence in the context of cannabis cultivation.

PubMed

Nguyen, Holly; Malm, Aili; Bouchard, Martin

2015-03-01

American authorities have invested extraordinary resources to keep up with the growth in cannabis cultivation, and state-level cannabis laws have been changing rapidly. Despite these changes, little research on the relationship between criminal justice sanctions and grower behaviours exist, in particular research that examines restrictive deterrence - the altering of an illegal behaviour as opposed to desisting from it completely. We examine restrictive deterrence in the context of cannabis cultivation by modelling the relationship between the threat of sanctions and the size of cultivation site and number of co-offenders. We use data from an anonymous web survey where participants were recruited through advertisements on websites related to cannabis use and cultivation. Negative binomial regression were used on 337 cases that contain valid data on size of cultivation site and 338 cases that contain valid data on the number of co-offenders. Our study found some evidence that the severity of state sanctions reduces the size of cultivation sites among growers who reside in the state. However, the number of contacts with the police had the opposite effect. In addition, we did not find a restrictive deterrent effect for the number of co-offenders, suggesting that different factors affect different decision points. Interestingly, objective skill and subjective skill had positive and independent effects on size of site. Results suggest that state-level sanctions have a structuring effect by restricting the size of cultivation sites but further increases in sanctions or enforcement are unlikely to deter more individuals from growing cannabis. In fact, there may be some potential dangers of increased enforcement on cannabis growers. Copyright © 2014 Elsevier B.V. All rights reserved.

Biting deterrence and insecticidal activity of hydrazide-hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles against Aedes aegypti.

PubMed

Tabanca, Nurhayat; Ali, Abbas; Bernier, Ulrich R; Khan, Ikhlas A; Kocyigit-Kaymakcioglu, Bedia; Oruç-Emre, Emine E; Unsalan, Seda; Rollas, Sevim

2013-06-01

Taking into account the improvement in insecticidal activity by the inclusion of fluorine in the hydrazone moiety, the authors synthesized new 4-fluorobenzoic acid hydrazides and 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles, substituting a phenyl group or a heteroaryl ring carrying one or two atoms of F, Cl and Br, and investigated their biting deterrent and larvicidal activities against Aedes aegypti for the first time. The compound 3-acetyl-5-(4-fluorophenyl)-2-[4-(dimethylamino)phenyl]-2,3-dihydro-1,3,4-oxadiazole (17) produced the highest biting deterrent activity (BDI = 1.025) against Ae. Aegypti, followed by 4-fluorobenzoic acid [(phenyl)methylene] hydrazide (1). These activity results were similar to those of N,N-diethyl-meta-toluamide (DEET), which showed a proportion not biting of 0.8-0.92. When compounds 1 and 17 were tested on cloth worn on human volunteers, compound 1 was not repellent for some volunteers until present in excess of 500 nmol cm(-2) , while compound 17 was not repellent at the highest concentration tested (1685 nmol cm(-2) ). In the larvicidal screening bioassays, only compounds 10, 11, 12 and 17 showed 100% mortality at the highest screening dose of 100 ppm against Ae. aegypti larvae. Compounds 11 and 12 with LD50 values of 24.1 and 30.9 ppm showed significantly higher mortality than 10 (80.3 ppm) and 17 (58.7 ppm) at 24-h post-treatment. The insecticidal and biting deterrent activities were correlated with the presence of a halogen atom on the phenyl or heteroaryl substituent of the hydrazone moiety. © 2012 Society of Chemical Industry.

Strategic Missile Defense & Nuclear Deterrence

NASA Astrophysics Data System (ADS)

Grego, Laura

The United States has pursued defenses against nuclear-armed long-range ballistic missiles since at least the 1950s. At the same time, concerns that missile defenses could undermine nuclear deterrence and potentially spark an arms race led the United States and Soviet Union to negotiate limits on these systems. The 1972 Anti-Ballistic Missile Treaty constrained strategic missile defenses for thirty years. After abandoning the treaty in 2002, President George W. Bush began fielding the Ground-based Midcourse Defense (GMD) homeland missile defense system on an extremely aggressive schedule, nominally to respond to threats from North Korea and Iran. Today, nearly fifteen years after its initial deployment, the potential and the limits of this homeland missile defense are apparent. Its test record is poor and it has no demonstrated ability to stop an incoming missile under real-world conditions. No credible strategy is in place to solve the issue of discriminating countermeasures. Insufficient oversight has not only exacerbated the GMD system's problems, but has obscured their full extent, which could encourage politicians and military leaders to make decisions that actually increase the risk of a missile attack against the United States. These are not the only costs. Both Russia and China have repeatedly expressed concerns that U.S. missile defenses adversely affect their own strategic capabilities and interests, particularly taken in light of the substantial US nuclear forces. This in turn affects these countries' nuclear modernization priorities. This talk will provide a technical overview of the US strategic missile defense system, and how it relates to deterrence against non-peer adversaries as well as how it affects deterrence with Russia and China and the long-term prospects for nuclear reductions

Six-month, open-label study of hydrocodone extended release formulated with abuse-deterrence technology: Safety, maintenance of analgesia, and abuse potential.

PubMed

Hale, Martin E; Ma, Yuju; Malamut, Richard

2016-01-01

To evaluate long-term safety, maintenance of analgesia, and aberrant drug-related behaviors of hydrocodone extended release (ER) formulated with CIMA® Abuse-Deterrence Technology. Phase 3, multicenter, open-label extension. Fifty-six US centers. Adults with chronic low back pain completing a 12-week placebocontrolled study of abuse-deterrent hydrocodone ER were eligible. One hundred eighty-two patients enrolled and received ≥1 dose of study drug, 170 entered openlabel treatment, and 136 completed the study. Patients receiving hydrocodone ER in the 12-week, placebo-controlled study continued their previous dose unless adjustment was needed; those previously receiving placebo (n=78) underwent dose titration/adjustment to an analgesic dose (15-90 mg every 12 hours). Patients received 22 weeks of open-label treatment. adverse events (AEs). Maintenance of analgesia: worst pain intensity (WPI) and average pain intensity (API) at each study visit. Aberrant drug behavior: study drug loss and diversion. AEs were reported for 65/182 (36 percent) patients during dose titration/ adjustment and 88/170 (52 percent) during open-label treatment. No treatmentrelated serious AEs were reported. There were no clinically meaningful trends in other safety assessments, including physical examinations and pure tone audiometry. One patient receiving hydrocodone ER 30 mg twice daily experienced a severe AE of neurosensory deafness that was considered treatment related. Mean WPI and API remained steady throughout open-label treatment. Six (3 percent) patients reported medication loss, and 5 (3 percent) reported diversion. Abuse-deterrent hydrocodone ER was generally well tolerated in patients with chronic low back pain, maintained efficacy, and was associated with low rates of loss and diversion.

The introduction of a potentially abuse deterrent oxycodone formulation: Early findings from the Australian National Opioid Medications Abuse Deterrence (NOMAD) study.

PubMed

Degenhardt, Louisa; Bruno, Raimondo; Ali, Robert; Lintzeris, Nicholas; Farrell, Michael; Larance, Briony

2015-06-01

There is increasing concern about tampering of pharmaceutical opioids. We describe early findings from an Australian study examining the potential impact of the April 2014 introduction of an abuse-deterrent sustained-release oxycodone formulation (Reformulated OxyContin(®)). Data on pharmaceutical opioid sales; drug use by people who inject drugs regularly (PWID); client visits to the Sydney Medically Supervised Injecting Centre (MSIC); and last drug injected by clients of inner-Sydney needle-syringe programmes (NSPs) were obtained, 2009-2014. A cohort of n=606 people tampering with pharmaceutical opioids was formed pre-April 2014, and followed up May-August 2014. There were declines in pharmacy sales of 80mg OxyContin(®) post-introduction of the reformulated product, the dose most commonly diverted and injected by PWID. Reformulated OxyContin(®) was among the least commonly used and injected drugs among PWID. This was supported by Sydney NSP data. There was a dramatic reduction in MSIC visits for injection of OxyContin(®) post-introduction of the new formulation (from 62% of monthly visits pre-introduction to 5% of visits, August 2014). The NOMAD cohort confirmed a reduction in OxyContin(®) use/injection post-introduction. Reformulated OxyContin(®) was cheaper and less attractive for tampering than Original OxyContin(®). These data suggest that, in the short term, introduction of an abuse-deterrent formulation of OxyContin(®) in Australia was associated with a reduction in injection of OxyContin(®), with no clear switch to other drugs. Reformulated OxyContin(®), in this short follow-up, does not appear to be considered as attractive for tampering. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Impact of abuse-deterrent OxyContin on prescription opioid utilization.

PubMed

Hwang, Catherine S; Chang, Hsien-Yen; Alexander, G Caleb

2015-02-01

We quantified the degree to which the August 2010 reformulation of abuse-deterrent OxyContin affected its use, as well as the use of alternative extended-release and immediate-release opioids. We used the IMS Health National Prescription Audit, a nationally representative source of prescription activity in the USA, to conduct a segmented time-series analysis of the use of OxyContin and other prescription opioids. Our primary time period of interest was 12 months prior to and following August 2010. We performed model checks and sensitivity analyses, such as adjusting for marketing and promotion, using alternative lag periods, and adding extra observation points. OxyContin sales were similar before and after the August 2010 reformulation, with approximately 550 000 monthly prescriptions. After adjusting for declines in the generic extended-release oxycodone market, the formulation change was associated with a reduction of approximately 18 000 OxyContin prescription sales per month (p = 0.02). This decline corresponded to a change in the annual growth rate of OxyContin use, from 4.9% prior to the reformulation to -23.8% during the year after the reformulation. There were no statistically significant changes associated with the sales of alternative extended-release (p = 0.42) or immediate-release (p = 0.70) opioids. Multiple sensitivity analyses supported these findings and their substantive interpretation. The market debut of abuse-deterrent OxyContin was associated with declines in its use after accounting for the simultaneous contraction of the generic extended-release oxycodone market. Further scrutiny into the effect of abuse-deterrent formulations on medication use and health outcomes is vital given their popularity in opioid drug development. Copyright © 2014 John Wiley & Sons, Ltd.

Insect Feeding Deterrents in Endophyte-Infected Tall Fescue †

PubMed Central

Johnson, M. C.; Dahlman, D. L.; Siegel, M. R.; Bush, L. P.; Latch, G. C. M.; Potter, D. A.; Varney, D. R.

1985-01-01

The presence of an endophytic fungus, Acremonium coenophialum, in tall fescue (Festuca arundinacea) deterred aphid feeding by Rhopalosiphum padi and Schizaphis graminum. Both species of aphid were unable to survive when confined to endophyte-infected tall fescue plants. Feeding deterrents and toxic factors to R. padi and Oncopeltus fasciatus, large milkweed bug, were primarily associated with a methanol extract obtained when endophyte-infected tall fescue seed was serially extracted with hexane, ethyl acetate, and methanol. The concentrations of pyrrolizidine alkaloids were determined to be 30 to 100 times greater in the methanol extract than in the hexane and ethyl acetate extracts. PMID:16346751

An overview of aerodynamic research and technology requirements as related to some military needs

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1983-01-01

Based on unclassified sources, a general review is presented of some military needs in light of the perceived U.S.S.R. doctrine, force balances, inventory growth, inventory items, and current actions. The Soviets appear to be attempting to increase their sphere of influence throught economic and political control as well as possible military control of land, sea, air, and space. To offset such possibilities, certain areas of deterrent needs that the Western World might pursue are suggested. Particular emphasis is placed on the role of research and technology related to aerospace systems as part of the deterrent needs.

Development concept for a small, split-core, heat-pipe-cooled nuclear reactor

NASA Technical Reports Server (NTRS)

Lantz, E.; Breitwieser, R.; Niederauer, G. F.

1974-01-01

There have been two main deterrents to the development of semiportable nuclear reactors. One is the high development costs; the other is the inability to satisfy with assurance the questions of operational safety. This report shows how a split-core, heat-pipe cooled reactor could conceptually eliminate these deterrents, and examines and summarizes recent work on split-core, heat-pipe reactors. A concept for a small reactor that could be developed at a comparatively low cost is presented. The concept would extend the technology of subcritical radioisotope thermoelectric generators using 238 PuO2 to the evolution of critical space power reactors using 239 PuO2.

Document fraud deterrent strategies: four case studies

NASA Astrophysics Data System (ADS)

Mercer, John W.

1998-04-01

This paper discusses the approaches taken to deter fraud committed against four documents: the machine-readable passport; the machine-readable visa; the Consular Report of Birth Abroad; and the Border Crossing Card. General approaches are discussed first, with an emphasis on the reasons for the document, the conditions of its use and the information systems required for it to function. A cost model of counterfeit deterrence is introduced. Specific approaches to each of the four documents are then discussed, in light of the issuance circumstances and criteria, the intent of the issuing authority, the applicable international standards and the level of protection and fraud resistance appropriate for the document.

Potential feeding deterrents found in hemlock woolly adelgid, Adelges tsugae

NASA Astrophysics Data System (ADS)

Jones, Anne C.; Mullins, Donald E.; Jones, Tappey H.; Salom, Scott M.

2012-07-01

The nonnative hemlock woolly adelgid ( Adelges tsugae Annand, Hemiptera: Sternorrhyncha: Adelgidae) has been a significant mortality agent of eastern hemlock ( Tsuga canadensis Carriere) throughout a large portion of its geographic range. During a study investigating adelgid vigor in relation to host health, it was noted that adelgid extracts ranged from a yellow to a deep red color. Analysis by GC-MS identified the presence of the anthraquinone, chrysophanol and its anthrone precursor, chrysarobin in the extract. These compounds are predator deterrents in several other insects, including chrysomelid beetles. It is hypothesized that these compounds serve a similar purpose in the hemlock woolly adelgid.

Gustatory receptor neuron responds to DEET and other insect repellents in the yellow-fever mosquito, Aedes aegypti

NASA Astrophysics Data System (ADS)

Sanford, Jillian L.; Shields, Vonnie D. C.; Dickens, Joseph C.

2013-03-01

Three gustatory receptor neurons were characterized for contact chemoreceptive sensilla on the labella of female yellow-fever mosquitoes, Aedes aegypti. The neuron with the smallest amplitude spike responded to the feeding deterrent, quinine, as well as N, N-diethyl-3-methylbenzamide and other insect repellents. Two other neurons with differing spikes responded to salt (NaCl) and sucrose. This is the first report of a gustatory receptor neuron specific for insect repellents in mosquitoes and may provide a tool for screening chemicals to discover novel or improved feeding deterrents and repellents for use in the management of arthropod disease vectors.

West European and East Asian Perspectives on Defense, Deterrence and Strategy. Volume 2. Western European Perspectives on Defense, Deterrence and Strategy.

DTIC Science & Technology

1984-05-16

3a - vDE Or 4EPORT 13b 󈨋M COvERED :W)AE OF REPOR~ r or ay 5~ COu.N. *Technical :ROM 821201 -o 8451" 1984, May 16"a 238" 0y 5-I o. * 6 Su POLEMETARY...34 International Defense Review, Vol. 12, No. 3 (1979). 82. Geneste, Colonel Marc. ’La Bataille Terrestre Nuc1~aire,5 Strategie, (July-September 1976). 83.t, u...Strategi- gues, Nucl~aires Tactiques, Terrestres Maritimes et Aeriennes,’ Le Figaro, April 21, 1983. 182. Everts, Philip P. ’Reviving Unilateralism

Nitrogenous ovipositional deterrents in the leaves of sweet pepper (Capsicum annuum) at the mature stage against the leafminer, Liriomyza trifolii (Burgess).

PubMed

Dekebo, Aman; Kashiwagi, Takehiro; Tebayashi, Shin-ich; Kim, Chul-Sa

2007-02-01

Mature leaves of the sweet pepper, Capsicum annuum, exhibited resistance against the American serpentine leafminer, Liriomyza trifolii (Burgess), Agromyzidae. Based on bioassay-guided fractionation, three compounds, namely 4-aminobutanoic acid, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidine carboxylic acid and 4-amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone, were isolated from the leaves of sweet pepper. These compounds had significant oviposition deterrence towards adult flies of L. trifolii from laying their eggs on host plant leaves treated at 3.70, 16.60 and 6.45 microg/cm(2), respectively.

Assessing the Impact of a Focused Deterrence Strategy to Combat Intimate Partner Domestic Violence.

PubMed

Sechrist, Stacy M; Weil, John D

2018-03-01

The Offender Focused Domestic Violence Initiative (OFDVI) represents for the first time anywhere the application of the evidence-based focused deterrence policing approach to combat intimate partner domestic violence (IPDV). Through holding offenders accountable, the strategy has resulted in 20% reductions each in IPDV-related calls for police service and arrests. Victim injuries have been significantly reduced and the 1-year IPDV offender recidivism rate is about 16-17%. The backbone of the OFDVI strategy is the multidisciplinary collaboration of law enforcement and community partners which has resulted in identification and resolving system issues which have historically allowed offenders to repeat IPDV without consequence.

Association between alcoholism and the dopamine D4 receptor gene.

PubMed Central

Muramatsu, T; Higuchi, S; Murayama, M; Matsushita, S; Hayashida, M

1996-01-01

A point mutation in the aldehyde dehydrogenase 2 gene (ALDH2(2) allele) is considered to be a genetic deterrent for alcoholism; however, 80 of 655 Japanese alcoholics had the mutant allele. Genotype factors that might increase susceptibility by overriding the deterrent showed a higher frequency of a five repeat allele of the dopamine D4 receptor 48 bp repeat polymorphism in alcoholics with ALDH2(2) than in 100 other alcoholics and 144 controls. Alcoholics with the five repeat allele also abused other drugs more often. These data suggest the involvement of the dopamine system in the development of alcoholism and other addictive behaviour. PMID:8929946

Examining deterrence of adult sex crimes: A semi-parametric intervention time series approach.

PubMed

Park, Jin-Hong; Bandyopadhyay, Dipankar; Letourneau, Elizabeth

2014-01-01

Motivated by recent developments on dimension reduction (DR) techniques for time series data, the association of a general deterrent effect towards South Carolina (SC)'s registration and notification (SORN) policy for preventing sex crimes was examined. Using adult sex crime arrestee data from 1990 to 2005, the the idea of Central Mean Subspace (CMS) is extended to intervention time series analysis (CMS-ITS) to model the sequential intervention effects of 1995 (the year SC's SORN policy was initially implemented) and 1999 (the year the policy was revised to include online notification) on the time series spectrum. The CMS-ITS model estimation was achieved via kernel smoothing techniques, and compared to interrupted auto-regressive integrated time series (ARIMA) models. Simulation studies and application to the real data underscores our model's ability towards achieving parsimony, and to detect intervention effects not earlier determined via traditional ARIMA models. From a public health perspective, findings from this study draw attention to the potential general deterrent effects of SC's SORN policy. These findings are considered in light of the overall body of research on sex crime arrestee registration and notification policies, which remain controversial.

Malpractice litigation and nursing home quality of care.

PubMed

Konetzka, R Tamara; Park, Jeongyoung; Ellis, Robert; Abbo, Elmer

2013-12-01

To assess the potential deterrent effect of nursing home litigation threat on nursing home quality. We use a panel dataset of litigation claims and Nursing Home Online Survey Certification and Reporting (OSCAR) data from 1995 to 2005 in six states: Florida, Illinois, Wisconsin, New Jersey, Missouri, and Delaware, for a total of 2,245 facilities. Claims data are from Westlaw's Adverse Filings database, a proprietary legal database, on all malpractice, negligence, and personal injury/wrongful death claims filed against nursing facilities. A lagged 2-year moving average of the county-level number of malpractice claims is used to represent the threat of litigation. We use facility fixed-effects models to examine the relationship between the threat of litigation and nursing home quality. We find significant increases in registered nurse-to-total staffing ratios in response to rising malpractice threat, and a reduction in pressure sores among highly staffed facilities. However, the magnitude of the deterrence effect is small. Deterrence in response to the threat of malpractice litigation is unlikely to lead to widespread improvements in nursing home quality. This should be weighed against other benefits and costs of litigation to assess the net benefit of tort reform. © Health Research and Educational Trust.

Insecticidal and Repellent Activity of Several Plant-Derived Essential Oils Against Aedes aegypti.

PubMed

Castillo, Ruth M; Stashenko, Elena; Duque, Jonny E

2017-03-01

We examined the pupicidal, adulticidal, repellent, and oviposition-deterrent activities of essential oils (EOs) from Lippia alba, L. origanoides, Eucalyptus citriodora, Cymbopogon citratus, Cymbopogon flexuosus, Citrus sinensis , Cananga odorata , Swinglea glutinosa, and Tagetes lucida plants against Aedes aegypti under laboratory conditions. Pupicidal and adulticidal activities were assessed at exploratory concentrations of 250, 310, and 390 parts per million (ppm); and 30, 300, and 1,000 ppm, respectively. The greatest pupicidal activity was exhibited at 390 ppm with a 24-h exposure by L. origanoides, and 390 ppm with a 48-h exposure by Citrus sinensis . Lippia origanoides killed all adult mosquitoes at 300 ppm after 120 min of exposure. Only L. origanoides and E. citriodora EOs, applied at 1,000 ppm to human skin, produced the greatest repellency (100%) to host-seeking Ae. aegypti after 2 min of exposure; the repellency decreased between 12% and 10% after 15 min. Complete oviposition deterrence by gravid Ae. aegypti was observed for E. citriodora EOs at 200 ppm with an oviposition activity index of -1.00. These results confirm that the EOs assessed in this study have insecticidal, repellent, and oviposition-deterrent activities against the dengue vector, Ae. aegypti.

Revitalizing Nuclear Operations in the Joint Environment

DTIC Science & Technology

2014-02-01

height of the Cold War, US schol - ars and joint operational planners were working simultaneously on weapons development and operational art to employ...leadership’s large-target- category withholds thought necessary to maintain stability in a strategic crisis. The inclusion of nuclear effects and...escalation. The inclusion of these points in tomorrow’s doctrine as well as an intellec- tual discussion on the topic will inform Joint Staff planners

Greek-Turkish Crises since 1955. Implications for Greek-Turkish Conflict Management

DTIC Science & Technology

1997-03-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS GREEK-TURKISH CRISES SINCE 1955. IMPLICATIONS FOR GREEK-TURKISH CONFLICT MANAGEMENT by...EU, WEU) have only to gain from a Greek-Turkish rapprochement. 14. SUBJECT TERMS GrEek-Turkish RElATiONS, CRiSiS MANAgEMENT, CONfLICT management 15...crises, because the intended outcome of mediation attempts has been regional stability instead of Greek-Turkish conflict management . Power mediation

Banking: shop and compare.

PubMed

O'Brien, Jennifer A; DeJarnette, Sherry

2014-01-01

There are many reasons to take a critical look at the practice's banking relationship(s)--technology advancements, security measures, improvements in available services, recent banking enhancements designed specifically for medical practices, the impact of the financial crisis on bank ratings and stability, changing practice needs, opportunities for operational automation at the practice--and it is just simply smart to periodically evaluate and compare the features, pricing, and potential savings offered by vendors.

On emissions trading, toxic debt and the Australian power market

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simshauser, Paul

2009-03-15

Implementation of emissions trading will have profound effects on the financial stability of coal generators. While the impact on equity capital is well understood, the potential fallout in the market for project finance is not. During the current global financial crisis, the form and quantum of transitional assistance to coal generators will be crucial to ensure ongoing participation of domestic and foreign project banks in the power markets. (author)

Regime shifts and panarchies in regional scale social ...

EPA Pesticide Factsheets

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises,

X-ray lasers: Strategic problems and potential as an in-orbit exoatmospheric ballistic missile defense system

NASA Astrophysics Data System (ADS)

Perusich, Karl Anthony

1986-12-01

The problems and potential of a single proposed ballistic missile defense system, the X-ray laser-armed satellite, are examined in this research. Specifically, the X-ray laser satellite system is examined to determine its impact on the issues of cost-effectiveness and crisis stability. To examime the cost-effectiveness and the crisis stability of the X-ray laser satellites, a simulation of a nuclear exchange was constructed. The X-ray laser satellites were assumed to be vulnerable to attack from energy satellites with limited satellite-to-satellite lethal ranges. Symmetric weapons and force postures were used. Five principal weapon classes were used in the model: ICMBs, SLBMs, X-ray laser satellites, bombers, and endo-atmospheric silo defenses. Also, the orbital dynamics of the ballistic missiles and satellites were simulated. The cost-effectiveness of the X-ray laser satellites was determined for two different operational capabilities, damage-limitation and assured destruction. The following conclusions were reached. The effects of deployment of a new weapon system on the Triad as a whole should be examined. The X-ray laser was found to have little effectiveness as a damage-limiting weapon for a defender. For an assured destruction capability, X-ray laser satellites could be part of a minimum-cost force mix with that capability.

The Humanitarian Situation in Syria: A Snapshot in the Third Year of the Crisis

PubMed Central

Doocy, Shannon; Delbiso, Tefera D.; Guha-Sapir, Debarati

2015-01-01

Between April and June 2014, International Orthodox Christian Charities (IOCC), an International NGO, and the Greek Orthodox Patriarchate of Antioch and All the East (GOPA) conducted a needs assessment of Syrians affected by the crisis with the objective of gaining a better understanding of humanitarian needs and assistance priorities. Findings suggest that interventions that increase access to non-food items, food, medication and education should be prioritized where cost was the primary barrier to accessing goods and services. Cash transfer programs and direct provision of material assistance should be considered, though the most appropriate assistance modality is likely to vary by sector, location and the preferences and prior experience of donors and implementing organizations. Renewed international commitment to funding humanitarian assistance efforts in Syria and neighboring countries where the burden of refugees is greatest is essential from both a human rights perspective and in terms of maintaining stability in the region. PMID:25821647

The humanitarian situation in syria: a snapshot in the third year of the crisis.

PubMed

Doocy, Shannon; Delbiso, Tefera D; Guha-Sapir, Debarati

2015-03-03

Between April and June 2014, International Orthodox Christian Charities (IOCC), an International NGO, and the Greek Orthodox Patriarchate of Antioch and All the East (GOPA) conducted a needs assessment of Syrians affected by the crisis with the objective of gaining a better understanding of humanitarian needs and assistance priorities. Findings suggest that interventions that increase access to non-food items, food, medication and education should be prioritized where cost was the primary barrier to accessing goods and services. Cash transfer programs and direct provision of material assistance should be considered, though the most appropriate assistance modality is likely to vary by sector, location and the preferences and prior experience of donors and implementing organizations. Renewed international commitment to funding humanitarian assistance efforts in Syria and neighboring countries where the burden of refugees is greatest is essential from both a human rights perspective and in terms of maintaining stability in the region.

Interlocking directorates in Irish companies using a latent space model for bipartite networks

PubMed Central

Friel, Nial; Rastelli, Riccardo; Wyse, Jason; Raftery, Adrian E.

2016-01-01

We analyze the temporal bipartite network of the leading Irish companies and their directors from 2003 to 2013, encompassing the end of the Celtic Tiger boom and the ensuing financial crisis in 2008. We focus on the evolution of company interlocks, whereby a company director simultaneously sits on two or more boards. We develop a statistical model for this dataset by embedding the positions of companies and directors in a latent space. The temporal evolution of the network is modeled through three levels of Markovian dependence: one on the model parameters, one on the companies’ latent positions, and one on the edges themselves. The model is estimated using Bayesian inference. Our analysis reveals that the level of interlocking, as measured by a contraction of the latent space, increased before and during the crisis, reaching a peak in 2009, and has generally stabilized since then. PMID:27247395

Impact of terrorism and political instability on equity premium: Evidence from Pakistan

NASA Astrophysics Data System (ADS)

MengYun, Wu; Imran, Muhammad; Zakaria, Muhammad; Linrong, Zhang; Farooq, Muhammad Umer; Muhammad, Shah Khalid

2018-02-01

The study quantifies the impact of terrorism and political instability on firm equity premium in Pakistan using panel data for 306 non-financial firms for the period 2001 to 2014. Other variables included are law & order, government regime change and financial crisis of 2007/08. The estimated results reveal that terrorism has statistically significant negative impact on firm equity premium in Pakistan. This result is robust with alternative equation specifications. The result also remains same when terrorism variable is replaced with external and internal conflict variables. Law & order variable has significant positive effect on firm equity premium, which implies that equity premium increases with the improvement in law & order situation in the country. Equity premium also increases with government stability and when there is democratic system in the country. The result also reveals that global financial crisis of 2007/08 negatively influenced the firm equity premium. The study suggests some policy implications.

From Discovery to Justification: Outline of an Ideal Research Program in Empirical Psychology

PubMed Central

Witte, Erich H.; Zenker, Frank

2017-01-01

The gold standard for an empirical science is the replicability of its research results. But the estimated average replicability rate of key-effects that top-tier psychology journals report falls between 36 and 39% (objective vs. subjective rate; Open Science Collaboration, 2015). So the standard mode of applying null-hypothesis significance testing (NHST) fails to adequately separate stable from random effects. Therefore, NHST does not fully convince as a statistical inference strategy. We argue that the replicability crisis is “home-made” because more sophisticated strategies can deliver results the successful replication of which is sufficiently probable. Thus, we can overcome the replicability crisis by integrating empirical results into genuine research programs. Instead of continuing to narrowly evaluate only the stability of data against random fluctuations (discovery context), such programs evaluate rival hypotheses against stable data (justification context). PMID:29163256

Thermohaline circulation crisis and impacts during the mid-Pleistocene transition.

PubMed

Pena, Leopoldo D; Goldstein, Steven L

2014-07-18

The mid-Pleistocene transition (MPT) marked a fundamental change in glacial-interglacial periodicity, when it increased from ~41-thousand-year to 100-thousand-year cycles and developed higher-amplitude climate variability without substantial changes in the Milankovitch forcing. Here, we document, by using Nd isotopes, a major disruption of the ocean thermohaline circulation (THC) system during the MPT between marine isotope stages (MISs) 25 and 21 at ~950 to 860 thousand years ago, which effectively marks the first 100-thousand-year cycle, including an exceptional weakening through a critical interglacial (MIS 23) at ~900 thousand years ago. Its recovery into the post-MPT 100-thousand-year world is characterized by continued weak glacial THC. The MPT ocean circulation crisis facilitated the coeval drawdown of atmospheric CO2 and high-latitude ice sheet growth, generating the conditions that stabilized 100-thousand-year cycles. Copyright © 2014, American Association for the Advancement of Science.

Interlocking directorates in Irish companies using a latent space model for bipartite networks.

PubMed

Friel, Nial; Rastelli, Riccardo; Wyse, Jason; Raftery, Adrian E

2016-06-14

We analyze the temporal bipartite network of the leading Irish companies and their directors from 2003 to 2013, encompassing the end of the Celtic Tiger boom and the ensuing financial crisis in 2008. We focus on the evolution of company interlocks, whereby a company director simultaneously sits on two or more boards. We develop a statistical model for this dataset by embedding the positions of companies and directors in a latent space. The temporal evolution of the network is modeled through three levels of Markovian dependence: one on the model parameters, one on the companies' latent positions, and one on the edges themselves. The model is estimated using Bayesian inference. Our analysis reveals that the level of interlocking, as measured by a contraction of the latent space, increased before and during the crisis, reaching a peak in 2009, and has generally stabilized since then.

Marital crises in oncology patients. An approach to initial intervention by primary clinicians.

PubMed

Peteet, J; Greenberg, B

1995-05-01

Life-threatening illnesses such as cancer may precipitate marital crises in vulnerable relationships, and oncology clinicians often feel uncertain about how to approach them. This paper presents a framework for initial intervention based on the nature of the principal threat to the relationship. Immature relationships need distance and support for their identity as a couple; hostile dependent couples need to find consensus in order to structure communication; physically abusive relationships require monitoring in order to promote safety; and estranged couples need help in understanding their disappointment and identifying available support. Clinicians working in oncology can help couples in crisis by promoting a realistic balance of independence and dependence, clarifying the complexity of factors contributing to the crisis, considering referral for couples treatment, communicating with the team while respecting patients' confidences, and by choosing clear and compatible clinical roles. Primary clinicians can stabilize and treat marital crises, but need access to medically knowledgeable couples' therapists.

The crisis of health in a crisis ridden region.

PubMed

Maziak, Wasim

2009-01-01

The overall picture of the Arab world today is dire; no Arab country is free from political strife, foreign intervention, or the threat of terrorism. Continuing instability and the failure of national governments to uphold the rule of law and deliver on development are tearing apart the fabric of Arab societies. Internally, Arab regimes' agendas are shaped by security and their makeup by kinship and loyalty, pushing people to seek refuge within their primordial loyalties. From the outside, foreign meddling in the name of "democracy" is deepening the Arab world's instability, therefore providing justification for opponents of change to discredit the values of human rights and power sharing. In such an environment, the voiceless majority becomes the main victims, with detrimental effects on their physical and mental wellbeing. A domino-like breakdown of the Arab region, with serious consequences for world's stability, is becoming an increasingly likely scenario.

Deterrence of device counterfeiting, cloning, and subversion by substitution using hardware fingerprinting

DOEpatents

Hamlet, Jason R; Bauer, Todd M; Pierson, Lyndon G

2014-09-30

Deterrence of device subversion by substitution may be achieved by including a cryptographic fingerprint unit within a computing device for authenticating a hardware platform of the computing device. The cryptographic fingerprint unit includes a physically unclonable function ("PUF") circuit disposed in or on the hardware platform. The PUF circuit is used to generate a PUF value. A key generator is coupled to generate a private key and a public key based on the PUF value while a decryptor is coupled to receive an authentication challenge posed to the computing device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

The bishops and nuclear weapons: The catholic pastoral letter on war and peace

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dougherty, J.E.

1984-01-01

This is a contribution to the Catholic debate over nuclear weapons, by an international relations scholar who teaches at a Catholic college. Dougherty is critical of the 1983 pastoral letter, arguing that it focuses too much on the dangers of nuclear war and the inadequacies of deterrence while giving insufficient attention to Soviet expansionism and the need for stable deterrence through a judicious mixture of military modernization and arms control. He is concerned by an increase in ''Catholic nuclear pacifism,'' fearing that the pastoral letter could become a theological rationalization for neo-isolationism in the United States. The European bishops, hemore » notes, take a more moderate view.« less

Measuring Oman’s Food Security Outlook for Crisis Aversion

DTIC Science & Technology

2015-05-18

unemployment benefits as well as more powers to the Majlis al-Shura.7 However, Oman could lose political stability in another food price spike, so it remains...population growth, arid climate, and government mismanagement has led to failing agricultural sectors and economic vulnerability.12 Today, most Arab...and two civil wars in Yemen and Syria continue today.19 While international organizations and non- governmental organizations like the World Bank and

The German Reunification Issue: A Soviet Perspective.

DTIC Science & Technology

1981-09-01

relationship with the Soviet Union is central to its viability, its economic stability, and the maintenance of its position in the Warsaw Pact. The...tion, and consumer spending is twice as high in the GDR than in the USSR. This voracious consumption is visible to Soviet troops. The Soviet Union...response to the prolonged Polish crisis, East and West Germany appear to be mutually shielding their special relationship from the cold East-West winds

Civil-Military Operations in the Post Conflict Environment: Northern Uganda Case Study

DTIC Science & Technology

2011-12-01

used to provide direct assistance in stabilizing a situation and building self -sufficient capacity in the crisis area. According to the U.S. SSTR...are a source of soft power to influence the population and avoid using kinetic military power. By deterring the population away from an insurgency...militaries train their personnel to coordinate, while humanitarian employees emphasize self -reliance in their areas of expertise.100 This disparity

The Military Dimension of the Niger Delta Crisis: Increasing the Effectiveness of Security Forces Through Information Operations

DTIC Science & Technology

2010-06-11

Torulagha makes strong accusations against the oil companies who he says barely conduct any environmental assessment before engaging in exploratory...residents widely regard the GoN as ―having collaborated with the multinational oil firms to alter the social and environmental stability of the area ...residents demanded resource control in the face of environmental degradation by multinational oil companies; and complaints of government marginalization

Stability Ops In The Western Hemisphere (CALL Newsletter, Number 11-15, February 2011)

DTIC Science & Technology

2011-02-01

Marulanda died on March 26, 2008. June 6 Colombia and Ecuador announce plans to restore full diplomatic relations. June-July Ecuadorean government ...and a continuing menace for Ecuador . On April 13, 2008, the Colombian government issued a communiqué stating that President Correa had prevented... governments . 3. Based on the events of March 1, 2008, the rudimentary system for early warning and crisis management between Colombia and Ecuador

Domestic Determinants and Security Policy-Making in East Asia

DTIC Science & Technology

2000-11-01

the U.S.-Japan alliance cannot be overstated as a foundation stone of Asia’s stability, the bilateral relationship has been sub- jected to heavy stress...financial crisis, are addressed by only a single department or ministry. ■ American neglect and Japanese obsession — With the purpose of the alliance ...requirement for a new rationale, fears weakening of American resolve to remain committed. Security independence by Japan and U.S. abandonment of the alliance

A Manual Control Test for the Detection and Deterrence of Impaired Drivers

NASA Technical Reports Server (NTRS)

Stein, A. C.; Allen, R. W.; Jex, H. R.

1984-01-01

A brief manual control test and a decision strategy were developed, laboratory tested, and field validated which provide a means for detecting human operator impairment from alcohol or other drugs. The test requires the operator to stabilize progressively unstable controlled element dynamics. Control theory and experimental data verify that the human operator's control ability on this task is constrained by basic cybernetic characteristics, and that task performance is reliably affected by impairment effects on these characteristics. Assessment of human operator control ability is determined by a statistically based decision strategy. The operator is allowed several chances to exceed a preset pass criterion. Procedures are described for setting the pass criterion based on individual ability and a desired unimpaired failure rate. These procedures were field tested with apparatus installed in automobiles that were designed to discourage drunk drivers from operating their vehicles. This test program demonstrated that the control task and detection strategy could be applied in a practical setting to screen human operators for impairment in their basic cybernetic skills.

Missile defense and strategic stability: Terminal High Altitude Area Defense (THAAD) in South Korea

DOE PAGES

Sankaran, Jaganath; Fearey, Bryan L.

2017-02-06

South Korea is threatened by its troubled relationship with North Korea. North Korea possesses a large cache of missiles as well as chemical and biological weapons, and the future potential to mount nuclear weapons on its missiles. The United States is also challenged because of its defense commitments to Seoul. As a countermeasure, the United States and South Korea decided to deploy Terminal High Altitude Area Defense (THAAD) missile defenses in South Korea. However, China has objected. Chinese scholars believe the THAAD radar would be able to track Chinese inter-continental ballistic missiles, thereby weakening their deterrent. A technical analysis doesmore » not support this assertion. But, it is vital for South Korea, given its proximity and economic interdependence, to reassure China. The United States Forces Korea will deploy THAD and that is not a commitment by Seoul to become part of U.S.-led missile defenses in the Asia-Pacific.« less

Missile defense and strategic stability: Terminal High Altitude Area Defense (THAAD) in South Korea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sankaran, Jaganath; Fearey, Bryan L.

South Korea is threatened by its troubled relationship with North Korea. North Korea possesses a large cache of missiles as well as chemical and biological weapons, and the future potential to mount nuclear weapons on its missiles. The United States is also challenged because of its defense commitments to Seoul. As a countermeasure, the United States and South Korea decided to deploy Terminal High Altitude Area Defense (THAAD) missile defenses in South Korea. However, China has objected. Chinese scholars believe the THAAD radar would be able to track Chinese inter-continental ballistic missiles, thereby weakening their deterrent. A technical analysis doesmore » not support this assertion. But, it is vital for South Korea, given its proximity and economic interdependence, to reassure China. The United States Forces Korea will deploy THAD and that is not a commitment by Seoul to become part of U.S.-led missile defenses in the Asia-Pacific.« less

Redefining the U.S. Agenda for Nuclear Disarmament, Analysis and Reflections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunn, Lewis A.

With Lewis Dunn’s paper on nuclear disarmament diplomacy, we are inaugurating a new monograph series under the auspices of the Center for Global Security Research at Lawrence Livermore National Laboratory. The series will explore complex emerging challenges in the emerging security environment as they bear on issues of deterrence, assurance, and strategic stability. Our goal is to explore these issues deeply enough to provide significant new understanding that is technically informed and policy relevant. Our premise is that thoughtful students of international security affairs continue to value such in-depth analysis as a way to help make sense of the largemore » flow of data and opinion that reaches all of us on a daily basis. Our ambition is to generate four to six such papers per year on especially salient topics. The views expressed in these papers are those of the author and should not be attributed to the Center, the Laboratory, or the U.S. government. This inaugural paper addresses one of the key questions facing national leadership seven to eight years after President Obama’s April 2009 remarks in Prague and his commitment to take practical steps towards the long-term goal of the elimination of nuclear weapons. In the interim, some important steps have been taken. But there have also been many disappointments. The new presidential administration will face a security landscape quite different from that of eight years ago and must reassess U.S. priorities and approaches. As Lewis Dunn argues, some will be tempted to walk away entirely from the disarmament agenda, while others will advocate even more forcefully for unilateral U.S. steps to further reduce the role and number of nuclear weapons in its posture. Dr. Dunn sets out his own vision of how to adapt and carry forward the disarmament agenda, in a manner informed by developments in the security environment that point to a continuing role for nuclear deterrence. The result is both fresh and compelling.« less

Acoustical deterrence of Silver Carp (Hypophthalmichthys molitrix)

USGS Publications Warehouse

Brooke J. Vetter,; Cupp, Aaron R.; Fredricks, Kim T.; Gaikowski, Mark P.; Allen F. Mensinger,

2015-01-01

The invasive Silver Carp (Hypophthalmichthys molitrix) dominate large regions of the Mississippi River drainage and continue to expand their range northward threatening the Laurentian Great Lakes. This study found that complex broadband sound (0–10 kHz) is effective in altering the behavior of Silver Carp with implications for deterrent barriers or potential control measures (e.g., herding fish into nets). The phonotaxic response of Silver Carp was investigated using controlled experiments in outdoor concrete ponds (10 × 4.9 × 1.2 m). Pure tones (500–2000 Hz) and complex sound (underwater field recordings of outboard motors) were broadcast using underwater speakers. Silver Carp always reacted to the complex sounds by exhibiting negative phonotaxis to the sound source and by alternating speaker location, Silver Carp could be directed consistently, up to 37 consecutive times, to opposite ends of the large outdoor pond. However, fish habituated quickly to pure tones, reacting to only approximately 5 % of these presentations and never showed more than two consecutive responses. Previous studies have demonstrated the success of sound barriers in preventing Silver Carp movement using pure tones and this research suggests that a complex sound stimulus would be an even more effective deterrent.

Waging modern war: An analysis of the moral literature on the nuclear arms debate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palmer-Fernandez, G.F.

1992-01-01

The primary aim was to examine the dominant views on the subject of deterrence and the use of nuclear weapons, to compare them with each other, and to consider objections that have or might be made against them. A second, more controversial and substantive, aim was to show that nuclear weapons and war-fighting plans engender some disturbing moral dilemmas that call into question fundamental ways of thinking about morality and some of the common intuitions on the relation of intentions and actions. The author examines the moral literature, both religious and secular, on nuclear arms policy written between the earlymore » 1960s and the late 1980s. Three different schools of thought, or parties,' are identified. To establish the differences among these parties, the author shows the various ways in which judgments on the use of nuclear weapons and on deterrence are linked either by a prohibitive moral principle which draws a moral equivalence going from action to intention or by a factual assumption about the nature of nuclear weapons. He concludes with the suggestion that the dilemmas that arise in the moral evaluation of nuclear deterrence represent a profound and much wider problem in moral theory between the ideals of character and the moral claims of politics.« less

Malpractice Litigation and Nursing Home Quality of Care

PubMed Central

Konetzka, R Tamara; Park, Jeongyoung; Ellis, Robert; Abbo, Elmer

2013-01-01

Objective. To assess the potential deterrent effect of nursing home litigation threat on nursing home quality. Data Sources/Study Setting. We use a panel dataset of litigation claims and Nursing Home Online Survey Certification and Reporting (OSCAR) data from 1995 to 2005 in six states: Florida, Illinois, Wisconsin, New Jersey, Missouri, and Delaware, for a total of 2,245 facilities. Claims data are from Westlaw's Adverse Filings database, a proprietary legal database, on all malpractice, negligence, and personal injury/wrongful death claims filed against nursing facilities. Study Design. A lagged 2-year moving average of the county-level number of malpractice claims is used to represent the threat of litigation. We use facility fixed-effects models to examine the relationship between the threat of litigation and nursing home quality. Principal Findings. We find significant increases in registered nurse-to-total staffing ratios in response to rising malpractice threat, and a reduction in pressure sores among highly staffed facilities. However, the magnitude of the deterrence effect is small. Conclusions. Deterrence in response to the threat of malpractice litigation is unlikely to lead to widespread improvements in nursing home quality. This should be weighed against other benefits and costs of litigation to assess the net benefit of tort reform. PMID:23741985

Effects of excipients and curing process on the abuse deterrent properties of directly compressed tablets.

PubMed

Rahman, Ziyaur; Zidan, Ahmed S; Korang-Yeboah, Maxwell; Yang, Yang; Siddiqui, Akhtar; Shakleya, Diaa; Khan, Mansoor A; Cruz, Celia; Ashraf, Muhammad

2017-01-30

The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox™ based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size distribution following mechanical manipulation, drug extraction in water and alcohol, syringeability and injectability. Other non-ADPs such as surface morphology and tablet dissolution were also studied. It was found that presence of 50% or more of water soluble or swellable excipient in the ADF tablets significantly affected the tablet hardness, particle size distribution following mechanical manipulation and drug extraction while small amount (5%) of excipients had either minimal or no effect on ADPs of these tablets. Addition of high molecular weight HPMC (K 100M) affected syringeability and injectability of ADF. Curing process was found to affect ADPs (hardness, particle size distribution, drug extraction and syringeability and injectability) when compared with uncured tablet. In conclusion, addition of large amount of excipients, especially water soluble ones in Polyox™ based ADF tablets increase the risk of abuse by various routes of administration. Published by Elsevier B.V.

Choosing Psychiatry as a Career: Motivators and Deterrents at a Critical Decision-Making Juncture

PubMed Central

Wiesenfeld, Lesley; Abbey, Susan; Takahashi, Sue Glover; Abrahams, Caroline

2014-01-01

Objective To examine factors influencing the choice of psychiatry as a career between residency program application and ranking decision making. Methods: Using an online questionnaire, applicants to the largest Canadian psychiatry residency program were surveyed about the impact of various factors on their ultimate decision to enter psychiatry residency training. Results: Applicants reported that patient-related stigma was a motivator in considering psychiatry as a career, but that negative comments from colleagues, friends, and family about choosing psychiatry was a deterrent. Training program length, limited treatments, and insufficient clerkship exposure were noted as deterrents to choosing psychiatry, though future job prospects, the growing role of neuroscience, and diagnostic complexity positively influenced choosing psychiatry as a specialty. Research and elective time away opportunities were deemed relatively unimportant to ranking decisions, compared with more highly weighted factors, such as program flexibility, emphasis on psychotherapy, service– training balance, and training program location. Most applicants also reported continuing to fine tune ranking decisions between the application and ranking submission deadline. Conclusions: Stigma, exposure to psychiatry, diagnostic complexity, and an encouraging job market were highlighted as positive influences on the choice to enter psychiatry residency. Interview and information days represent opportunities for continued targeted recruitment activity for psychiatry residency programs. PMID:25161070

A Biomimetic Ultrasonic Whistle for Use as a Bat Deterrent on Wind Turbines

NASA Astrophysics Data System (ADS)

Sievert, Paul; Seyed-Aghazadeh, Banafsheh; Carlson, Daniel; Dowling, Zara; Modarres-Sadeghi, Yahya

2016-11-01

As wind energy continues to gain worldwide prominence, more and more turbines are detrimentally influencing bat colonies. In 2012 alone, an estimated 600,000 bats were killed by wind turbines in the United States. Bats show a tendency to fly towards turbines. The objective of this work is to deter bats from the proximity of the swept area of operational wind turbine blades. Established field studies have shown that bats avoid broadband ultrasonic noise on the same frequency spectrum as their echolocation chirps. A biomimetic ultrasonic pulse generator for use as a bat deterrent on wind turbines is designed and studied experimentally. This device, which works based on the fundamentals of flow-induced oscillations of a flexible sheet is a whistle-like device inspired by a bat larynx, mechanically powered via air flow on a wind turbine blade. Current device prototypes have proven robust at producing ultrasound across the 20 - 70 kHz range for flow inlet velocities of 4 - 14 m/s. Ultimately, a deterrent as described here could provide a reliable, cost-effective means of alerting bats to the presence of moving turbine blades, reducing bat mortality at wind facilities, and reducing regulatory uncertainty for wind facility developers. The financial support provided by the US Department of Energy, and the Massachusetts Clean Energy center is acknowledged.

Reexamining the frequency range of hearing in silver (Hypophthalmichthys molitrix) and bighead (H. nobilis) carp

USGS Publications Warehouse

Vetter, Brooke J.; Brey, Marybeth; Meninger, Allen F.

2018-01-01

Silver (Hypophthalmichthys molitrix) and bighead (H. nobilis) carp (collectively bigheaded carp) are invasive fish that threaten aquatic ecosystems in the upper Midwest United States and the Laurentian Great Lakes. Controlling bigheaded carp is a priority of fisheries managers and one area of focus involves developing acoustic deterrents to prevent upstream migration. For an acoustic deterrent to be effective however, the hearing ability of bigheaded carp must be characterized. A previous study showed that bigheaded carp detected sound up to 3 kHz but this range is narrower than what has been reported for other ostariophysans. Therefore, silver and bighead carp frequency detection was evaluated in response to 100 Hz to 9 kHz using auditory evoked potentials (AEPs). AEPs were recorded from 100 Hz to 5 kHz. The lowest thresholds were at 500 Hz for both species (silver carp threshold: 80.6 ± 3.29 dB re 1 μPa SPLrms, bighead carp threshold: 90.5 ± 5.75 dB re 1 μPa SPLrms; mean ± SD). These results provide fisheries managers with better insight on effective acoustic stimuli for deterrent systems, however, to fully determine bigheaded carp hearing abilities, these results need to be compared with behavioral assessments.

Pathways towards instability in financial networks

NASA Astrophysics Data System (ADS)

Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

2017-02-01

Following the financial crisis of 2007-2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network models, the details of how financial institutions interact typically play a decisive role, and a general understanding of precisely how network topology creates instability remains lacking. Here we show how processes that are widely believed to stabilize the financial system, that is, market integration and diversification, can actually drive it towards instability, as they contribute to create cyclical structures which tend to amplify financial distress, thereby undermining systemic stability and making large crises more likely. This result holds irrespective of the details of how institutions interact, showing that policy-relevant analysis of the factors affecting financial stability can be carried out while abstracting away from such details.

Pathways towards instability in financial networks

PubMed Central

Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

2017-01-01

Following the financial crisis of 2007–2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network models, the details of how financial institutions interact typically play a decisive role, and a general understanding of precisely how network topology creates instability remains lacking. Here we show how processes that are widely believed to stabilize the financial system, that is, market integration and diversification, can actually drive it towards instability, as they contribute to create cyclical structures which tend to amplify financial distress, thereby undermining systemic stability and making large crises more likely. This result holds irrespective of the details of how institutions interact, showing that policy-relevant analysis of the factors affecting financial stability can be carried out while abstracting away from such details. PMID:28221338

Pathways towards instability in financial networks.

PubMed

Bardoscia, Marco; Battiston, Stefano; Caccioli, Fabio; Caldarelli, Guido

2017-02-21

Following the financial crisis of 2007-2008, a deep analogy between the origins of instability in financial systems and complex ecosystems has been pointed out: in both cases, topological features of network structures influence how easily distress can spread within the system. However, in financial network models, the details of how financial institutions interact typically play a decisive role, and a general understanding of precisely how network topology creates instability remains lacking. Here we show how processes that are widely believed to stabilize the financial system, that is, market integration and diversification, can actually drive it towards instability, as they contribute to create cyclical structures which tend to amplify financial distress, thereby undermining systemic stability and making large crises more likely. This result holds irrespective of the details of how institutions interact, showing that policy-relevant analysis of the factors affecting financial stability can be carried out while abstracting away from such details.

An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission

PubMed Central

2014-01-01

Background Current malaria vector control programmes rely on insecticides with rapid contact toxicity. However, spatial repellents can also be applied to reduce man-vector contact, which might ultimately impact malaria transmission. The aim of this study was to quantify effects of airborne pyrethroids from coils and DDT used an indoor residual spray (IRS) on entomological parameters that influence malaria transmission. Methods The effect of Transfluthrin and Metofluthrin coils compared to DDT on house entry, exit and indoor feeding behaviour of Anopheles gambiae sensu lato were measured in experimental huts in the field and in the semi-field. Outcomes were deterrence - reduction in house entry of mosquitoes; irritancy or excito-repellency – induced premature exit of mosquitoes; blood feeding inhibition and effect on mosquito fecundity. Results Transfluthrin coils, Metofluthrin coils and DDT reduced human vector contact through deterrence by 38%, 30% and 8%, respectively and induced half of the mosquitoes to leave huts before feeding (56%, 55% and 48%, respectively). Almost all mosquitoes inside huts with Metofluthrin and Transfluthrin coils and more than three quarters of mosquitoes in the DDT hut did not feed, almost none laid eggs and 67%, 72% and 70% of all mosquitoes collected from Transfluthrin, Metofluthrin and DDT huts, respectively had died after 24 hours. Conclusion This study highlights that airborne pyrethroids and DDT affect a range of anopheline mosquito behaviours that are important parameters in malaria transmission, namely deterrence, irritancy/excito-repellency and blood-feeding inhibition. These effects are in addition to significant toxicity and reduced mosquito fecundity that affect mosquito densities and, therefore, provide community protection against diseases for both users and non-users. Airborne insecticides and freshly applied DDT had similar effects on deterrence, irritancy and feeding inhibition. Therefore, it is suggested that airborne pyrethroids, if delivered in suitable formats, may complement existing mainstream vector control tools. PMID:24693934

INDIA’S GROWING INFLUENCE IN STABILIZING REGIONAL SECURITY IN SOUTHEAST ASIA

DTIC Science & Technology

2016-02-16

in this academic research paper are those of the author and do not reflect the official policy or position of the US government , the Department of...Defense, or Air University. In accordance with Air Force Instruction 51-303, it is not copyrighted but is the property of the United States government ...Change in the global political and economic structure, unstable Indian government from the end of 1989 till mid-1991, internal political crisis

Low income Russian families adopt effective behavioral strategies to maintain dietary stability in times of economic crisis.

PubMed

Dore, Anna R; Adair, Linda S; Popkin, Barry M

2003-11-01

The social, political and economic reforms of 1992 in Russia led to a decade of rising income inequality, unemployment and economic crises, the most severe of which occurred in 1998. This study assesses dietary trends for children in low and high income households during this politically and economically unstable period from 1994 to 2000. Several possible food-related behaviors were also assessed to evaluate coping strategies adopted in the face of decreasing economic stability. Low income children maintained a steady energy intake per kilogram weight throughout the study period (251.0-259.4 kJ/kg), whereas intake for high income children increased significantly to a per capital average of 297.1 kJ/kg by 2000. At the food group level, the trend in per capita intake for all food groups was maintained for low income children except for a 22% decrease in meat and poultry consumption (P < 0.01). Per capita intake increased over time for dairy products and eggs in the high income group (P < 0.01). A decrease in cost per kJ (rubles/kJ) was observed for both low and high income families (P < 0.01). These data suggest that Russian households were able to conserve the diet structure for children by using what appear to be food-related behavioral mechanisms during periods of economic crisis.

DTIC review. Volume 1, Number 1: Nuclear proliferation and deterrence in a changing political world

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cupp, C.M.; Lee, C.; Foster, H.

1995-08-01

This collection of selected documents from the Defense Technical Information Center (DTIC) addresses the formidable issue of protecting the United States and its people from potential nuclear destruction. With the dissolution of the former Soviet Union and, concomitantly, the end of the Cold War, new strategies for nonproliferation and deterrence must be devised and implemented. Potential threats from countries not previously seen as a danger, the escalation of regional conflicts and the proliferation of weapons of mass destruction are but a few of the considerations to be addressed. The authors of the following papers propose various plans and tactics tomore » ensure United States national security and maintain world peace.« less

The impact of no-fault compensation on health care expenditures: an empirical study of OECD countries.

PubMed

Vandersteegen, Tom; Marneffe, Wim; Cleemput, Irina; Vereeck, Lode

2015-03-01

Around the world, governments are faced with spiralling health care expenditures. This raises the need for further insight in the determinants of these expenditures. Existing literature focuses primarily on income, ageing, health care financing and supply variables. This paper includes medical malpractice system characteristics as determinants of health spending in OECD countries. Estimates from our regression models suggest that no-fault schemes for medical injuries with decoupling of deterrence and compensation reduce health expenditures per capita by 0.11%. Furthermore, countries that introduced a no-fault system without decoupling of deterrence and compensation are found to have higher (+0.06%) health care spending. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Stockpile Stewardship: How We Ensure the Nuclear Deterrent Without Testing

ScienceCinema

None

2018-01-16

In the 1990s, the U.S. nuclear weapons program shifted emphasis from developing new designs to dismantling thousands of existing weapons and maintaining a much smaller enduring stockpile. The United States ceased underground nuclear testing, and the Department of Energy created the Stockpile Stewardship Program to maintain the safety, security, and reliability of the U.S. nuclear deterrent without full-scale testing. This video gives a behind the scenes look at a set of unique capabilities at Lawrence Livermore that are indispensable to the Stockpile Stewardship Program: high performance computing, the Superblock category II nuclear facility, the JASPER a two stage gas gun, the High Explosive Applications Facility (HEAF), the National Ignition Facility (NIF), and the Site 300 contained firing facility.

Acoustic deterrence of bighead carp (Hypophthalmichthys nobilis) to a broadband sound stimulus

USGS Publications Warehouse

Vetter, Brooke J.; Murchy, Kelsie; Cupp, Aaron R.; Amberg, Jon J.; Gaikowski, Mark P.; Mensinger, Allen F.

2017-01-01

Recent studies have shown the potential of acoustic deterrents against invasive silver carp (Hypophthalmichthys molitrix). This study examined the phonotaxic response of the bighead carp (H. nobilis) to pure tones (500–2000 Hz) and playbacks of broadband sound from an underwater recording of a 100 hp outboard motor (0.06–10 kHz) in an outdoor concrete pond (10 × 5 × 1.2 m) at the U.S. Geological Survey Upper Midwest Environmental Science Center in La Crosse, WI. The number of consecutive times the fish reacted to sound from alternating locations at each end of the pond was assessed. Bighead carp were relatively indifferent to the pure tones with median consecutive responses ranging from 0 to 2 reactions away from the sound source. However, fish consistently exhibited significantly (P < 0.001) greater negative phonotaxis to the broadband sound (outboard motor recording) with an overall median response of 20 consecutive reactions during the 10 min trials. In over 50% of broadband sound tests, carp were still reacting to the stimulus at the end of the trial, implying that fish were not habituating to the sound. This study suggests that broadband sound may be an effective deterrent to bighead carp and provides a basis for conducting studies with wild fish.

What Deters Crime? Comparing the Effectiveness of Legal, Social, and Internal Sanctions Across Countries.

PubMed

Mann, Heather; Garcia-Rada, Ximena; Hornuf, Lars; Tafurt, Juan

2016-01-01

The question of what deters crime is of both theoretical and practical interest. The present paper focuses on what factors deter minor, non-violent crimes, i.e., dishonest actions that violate the law. Much research has been devoted to testing the effectiveness of legal sanctions on crime, while newer models also include social sanctions (judgment of friends or family) and internal sanctions (feelings of guilt). Existing research suggests that both internal sanctions and, to a lesser extent, legal sanctions deter crime, but it is unclear whether this pattern is unique to Western countries or robust across cultures. We administered a survey study to participants in China, Colombia, Germany, Portugal, and USA, five countries from distinct cultural regions of the world. Participants were asked to report the likelihood of engaging in seven dishonest and illegal actions, and were asked to indicate the probability and severity of consequences for legal, friend, family, and internal sanctions. Results indicated that across countries, internal sanctions had the strongest deterrent effects on crime. The deterrent effects of legal sanctions were weaker and varied across countries. Furthermore, the deterrent effects of legal sanctions were strongest when internal sanctions were lax. Unexpectedly, social sanctions were positively related to likelihood of engaging in crime. Taken together, these results suggest that the relative strengths of legal and internal sanctions are robust across cultures and dishonest actions.

What Deters Crime? Comparing the Effectiveness of Legal, Social, and Internal Sanctions Across Countries

PubMed Central

Mann, Heather; Garcia-Rada, Ximena; Hornuf, Lars; Tafurt, Juan

2016-01-01

The question of what deters crime is of both theoretical and practical interest. The present paper focuses on what factors deter minor, non-violent crimes, i.e., dishonest actions that violate the law. Much research has been devoted to testing the effectiveness of legal sanctions on crime, while newer models also include social sanctions (judgment of friends or family) and internal sanctions (feelings of guilt). Existing research suggests that both internal sanctions and, to a lesser extent, legal sanctions deter crime, but it is unclear whether this pattern is unique to Western countries or robust across cultures. We administered a survey study to participants in China, Colombia, Germany, Portugal, and USA, five countries from distinct cultural regions of the world. Participants were asked to report the likelihood of engaging in seven dishonest and illegal actions, and were asked to indicate the probability and severity of consequences for legal, friend, family, and internal sanctions. Results indicated that across countries, internal sanctions had the strongest deterrent effects on crime. The deterrent effects of legal sanctions were weaker and varied across countries. Furthermore, the deterrent effects of legal sanctions were strongest when internal sanctions were lax. Unexpectedly, social sanctions were positively related to likelihood of engaging in crime. Taken together, these results suggest that the relative strengths of legal and internal sanctions are robust across cultures and dishonest actions. PMID:26903898

Formulation Optimization of Hot Melt Extruded Abuse Deterrent Pellet Dosage Form Utilizing Design of Experiments (DOE)

PubMed Central

Maddineni, Sindhuri; Battu, Sunil Kumar; Morott, Joe; Majumdar, Soumyajit; Repka, Michael A.

2014-01-01

The objective of the present study was to develop techniques for an abuse-deterrent (AD) platform utilizing hot melt extrusion (HME) process. Formulation optimization was accomplished by utilizing Box-Behnken design of experiments to determine the effect of the three formulation factors: PolyOx™ WSR301, Benecel™ K15M, and Carbopol 71G; each of which was studied at three levels on TR attributes of the produced melt extruded pellets. A response surface methodology was utilized to identify the optimized formulation. Lidocaine Hydrochloride was used as a model drug, and suitable formulation ingredients were employed as carrier matrices and processing aids. All of the formulations were evaluated for the TR attributes such as particle size post-milling, gelling, percentage of drug extraction in water and alcohol. All of the DOE formulations demonstrated sufficient hardness and elasticity, and could not be reduced into fine particles (<150µm), which is a desirable feature to prevent snorting. In addition, all of the formulations exhibited good gelling tendency in water with minimal extraction of drug in the aqueous medium. Moreover, Benecel™ K15M in combination with PolyOx™ WSR301 could be utilized to produce pellets with TR potential. HME has been demonstrated to be a viable technique with a potential to develop novel abuse-deterrent formulations. PMID:24433429

How Bees Deter Elephants: Beehive Trials with Forest Elephants (Loxodonta africana cyclotis) in Gabon.

PubMed

Ngama, Steeve; Korte, Lisa; Bindelle, Jérôme; Vermeulen, Cédric; Poulsen, John R

2016-01-01

In Gabon, like elsewhere in Africa, crops are often sources of conflict between humans and wildlife. Wildlife damage to crops can drastically reduce income, amplifying poverty and creating a negative perception of wild animal conservation among rural people. In this context, crop-raiding animals like elephants quickly become "problem animals". To deter elephants from raiding crops beehives have been successfully employed in East Africa; however, this method has not yet been tested in Central Africa. We experimentally examined whether the presence of Apis mellifera adansonii, the African honey bee species present in Central Africa, deters forest elephants (Loxodonta Africana cyclotis) from feeding on fruit trees. We show for the first time that the effectiveness of beehives as deterrents of elephants is related to bee activity. Empty hives and those housing colonies of low bee activity do not deter elephants all the time; but beehives with high bee activity do. Although elephant disturbance of hives does not impede honey production, there is a tradeoff between deterrence and the quantity of honey produced. To best achieve the dual goals of deterring elephants and producing honey colonies must maintain an optimum activity level of 40 to 60 bee movements per minute. Thus, beehives colonized by Apis mellifera adansonii bees can be effective elephant deterrents, but people must actively manage hives to maintain bee colonies at the optimum activity level.

Variability in chemical defense across a shallow to mesophotic depth gradient in the Caribbean sponge Plakortis angulospiculatus

NASA Astrophysics Data System (ADS)

Slattery, Marc; Gochfeld, Deborah J.; Diaz, M. Cristina; Thacker, Robert W.; Lesser, Michael P.

2016-03-01

The transition between shallow and mesophotic coral reef communities in the tropics is characterized by a significant gradient in abiotic and biotic conditions that could result in potential trade-offs in energy allocation. The mesophotic reefs in the Bahamas and the Cayman Islands have a rich sponge fauna with significantly greater percent cover of sponges than in their respective shallow reef communities, but relatively low numbers of spongivores. Plakortis angulospiculatus, a common sponge species that spans the depth gradient from shallow to mesophotic reefs in the Caribbean, regenerates faster following predation and invests more energy in protein synthesis at mesophotic depths compared to shallow reef conspecifics. However, since P. angulospiculatus from mesophotic reefs typically contain lower concentrations of chemical feeding deterrents, they are not able to defend new tissue from predation as efficiently as conspecifics from shallow reefs. Nonetheless, following exposure to predators on shallow reefs, transplanted P. angulospiculatus from mesophotic depths developed chemical deterrence to predatory fishes. A survey of bioactive extracts indicated that a specific defensive metabolite, plakortide F, varied in concentration with depth, producing altered deterrence between shallow and mesophotic reef P. angulospiculatus. Different selective pressures in shallow and mesophotic habitats have resulted in phenotypic plasticity within this sponge species that is manifested in variable chemical defense and tissue regeneration at wound sites.

Transduction mechanism(s) of Na-saccharin in the blowfly Protophormia terraenovae: evidence for potassium and calcium conductance involvement.

PubMed

Masala, Carla; Solari, Paolo; Sollai, Giorgia; Crnjar, Roberto; Liscia, Anna

2009-12-01

The study on transduction mechanisms underlying bitter stimuli is a particularly intriguing challenge for taste researchers. The present study investigates, in the labellar chemosensilla of the blowfly Protophormia terraenovae, the transduction mechanism by which saccharin evokes the response of the "deterrent" cell, with particular attention to the contribution of K(+) and Ca(2+) current and the role of cyclic nucleotides, since second messengers modulate Ca(2+), Cl(-) and K(+) currents to different extents. As assessed by extracellular single-sensillum recordings, our results show that the addition of a Ca(2+) chelator such as EGTA or the Ca(2+) current blockers SK&F-96365, Mibefradil, Nifedipine and W-7 decrease the response of the "deterrent" cell to saccharin. A similar decreasing effect was also obtained following the addition of 4-aminopyridine, a K(+) current blocker. On the contrary, the membrane-permeable cyclic nucleotide 8-bromoguanosine 3',5'-cyclic monophosphate (8Br-cGMP) activates this cell and shows an additive effect when presented mixed with saccharin. Our results are consistent with the hypothesis that in the labellar chemosensilla of the blowfly both Ca(2+) and K(+) ions are involved in the transduction mechanism of the "deterrent" cell in response to saccharin. Our results also suggest a possible pathway common to saccharin and 8Br-cGMP.

NATO (North Atlantic Treaty Organization) deterrence and defense after the INF (Intermediate-Range Nuclear Forces) treaty. Final report, June 1988-June 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garrett, S.A.

1989-06-21

The treaty between the Soviet Union and the United States eliminating a whole class of intermediate-range nuclear forces (INF) in Europe raises a number of questions about NATO's future ability to deter Warsaw Pact aggression. Future choices on Alliance strategy and doctrine will be influenced by a variety of factors, including the image of new thinking in Soviet security policy enunciated by General Secretary Gorbachev, changing West European opinion toward the use of nuclear weapons for NATO deterrence, the complications inherent in further nuclear and conventional arms-control negotiations, assessments of the current conventional arms balance in Europe, and ongoing questionsmore » about NATO cohesion as well as the continued coupling of American security with that of her European allies. In the post-INF environment it may well be that U.S. Navy nuclear assets will assume an increasingly important role, particularly the Tomahawk Land Attack Missile/Nuclear (TLAM/N). The TLAM/N has many attractive attributes that can be supportive of NATO deterrence of the WTO, but there are also a number of unresolved questions to be addressed concerning this particular weapons system. Modernization of NATO's land-based short-range nuclear forces (SNF), such as the Lance missile, is also seen by many as critical to the maintenance of Alliance security in the aftermath of INF.« less

How Bees Deter Elephants: Beehive Trials with Forest Elephants (Loxodonta africana cyclotis) in Gabon

PubMed Central

Ngama, Steeve; Korte, Lisa; Bindelle, Jérôme; Vermeulen, Cédric; Poulsen, John R.

2016-01-01

In Gabon, like elsewhere in Africa, crops are often sources of conflict between humans and wildlife. Wildlife damage to crops can drastically reduce income, amplifying poverty and creating a negative perception of wild animal conservation among rural people. In this context, crop-raiding animals like elephants quickly become “problem animals”. To deter elephants from raiding crops beehives have been successfully employed in East Africa; however, this method has not yet been tested in Central Africa. We experimentally examined whether the presence of Apis mellifera adansonii, the African honey bee species present in Central Africa, deters forest elephants (Loxodonta Africana cyclotis) from feeding on fruit trees. We show for the first time that the effectiveness of beehives as deterrents of elephants is related to bee activity. Empty hives and those housing colonies of low bee activity do not deter elephants all the time; but beehives with high bee activity do. Although elephant disturbance of hives does not impede honey production, there is a tradeoff between deterrence and the quantity of honey produced. To best achieve the dual goals of deterring elephants and producing honey colonies must maintain an optimum activity level of 40 to 60 bee movements per minute. Thus, beehives colonized by Apis mellifera adansonii bees can be effective elephant deterrents, but people must actively manage hives to maintain bee colonies at the optimum activity level. PMID:27196059

Blunt impact as deterrent: human approach-avoidance behaviors and other stress responses studied within a paintball gaming context

NASA Astrophysics Data System (ADS)

Short, Kenneth R.; Bergen, Michael T.; DeMarco, Robert M.; Chua, Florence B.; Servatius, Richard J.

2006-05-01

Blunt impact munitions are often used by civilian law enforcement and in military operations on urban terrain (MOUT) missions to dissuade individuals and groups from approaching valued assets. The use of blunt munitions (rubber-ball or sponge) is predicated on their effectiveness as aversive stimuli; the effectiveness is weighed against the risk of serious injury or death. However, little empirical evidence supports effectiveness. Here, we use a paintball gaming context to study the effects of blunt impact on performance and approach behaviors. Volunteers individually traversed a course in which targets offer the opportunity to gain for accuracy. While completing the targeting task, subjects were bombarded with paintballs, which progressively became more numerous and the impact more intense as the subjects neared goal locations. Initial data suggest that over 30 blunt impacts by paintballs delivered at 280 ft/sec over 30 to 100 ft are insufficient to overcome intrinsic and extrinsic approach motivations or impair targeting or advance performance in an overwhelming majority of subjects. Our apparent ceiling effect was surprising. A sub-comparison of the few subjects who stopped the game before the end with those who did not suggests that personality factors influence the effectiveness of blunt impact as a deterrent. While paintballs differ from traditional blunt impact munitions on a number of physical characteristics, impact that was sufficient to repeatedly bruise volunteers was not an effective deterrent.

Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations.

PubMed

Walter, Carmen; Knothe, Claudia; Lötsch, Jörn

2016-07-01

Abuse-deterrent formulations (ADFs) are technologically sophisticated pharmaceutical formulations that impede manipulation and extraction of opioids and/or provoke unpleasant effects when they are taken in excessive quantity. This is implemented by creating physical barriers, inseparably combining the opioid with an opioid antagonist or adding aversive agents to the formulation. These pharmaceutical changes may potentially alter the pharmacokinetics and consequently the pharmacodynamics of the opioid. In this review, comparative evidence on pharmacokinetic differences between abuse-deterrent and classical formulations of the same opioids is summarized; furthermore, pharmacodynamic differences, with a focus on analgesia and abuse-related symptoms, are addressed. Most of the 12 studies comparing opioid pharmacokinetics have judged the physically intact ADF as being bioequivalent to the corresponding classical formulation. Pharmacokinetic differences have, however, been reported with physically manipulated ADFs and have ranged from moderate deviations from bioequivalence to complete changes in the pharmacokinetic profile (e.g. from a sustained-release formulation to a fast-release formulation). Pharmacodynamic effects were assessed in 14 comparative studies, which reported that intact ADFs usually provided clinically equivalent analgesia and clear advantages with respect to their addiction potential. However, withdrawal symptoms could be induced by the ADFs, although rarely and, in particular, when the ADFs had been physically altered. This evidence suggests that opioid ADFs are a working concept resulting in mostly minor pharmacokinetic and pharmacodynamic differences in comparison with classical formulations; however, they may deviate from this equivalence when physically altered.

Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.

PubMed

Pszczolkowski, Maciej A; Durden, Kevin; Sellars, Samantha; Cowell, Brian; Brown, John J

2011-10-26

Codling moth, Cydia pomonella (L.), is a cosmopolitan pest of apple, potentially causing severe damage to the fruit. Currently used methods of combating this insect do not warrant full success or are harmful to the environment. The use of plant-derived semiochemicals for manipulation with fruit-infesting behavior is one of the new avenues for controlling this pest. Here, we explore the potential of Ginkgo biloba and its synthetic metabolites for preventing apple feeding and infestation by neonate larvae of C. pomonella. Experiments with crude extracts indicated that deterrent constituents of ginkgo are present among alkylphenols, terpene trilactones, and flavonol glycosides. Further experiments with ginkgo synthetic metabolites of medical importance, ginkgolic acids, kaempferol, quercetin, isorhamnetin, ginkgolides, and bilobalide, indicated that three out of these chemicals have feeding deterrent properties. Ginkgolic acid 15:0 prevented fruit infestation at concentrations as low as 1 mg/mL, bilobalide had deterrent effects at 0.1 mg/mL and higher concentrations, and ginkgolide B at 10 mg/mL. On the other hand, kaempferol and quercetin promoted fruit infestation by codling moth neonates. Ginkgolic acids 13:0, 15:1, and 17:1, isorhamnetin, and ginkgolides A and C had no effects on fruit infestation-related behavior. Our research is the first report showing that ginkgo constituents influence fruit infestation behavior and have potential applications in fruit protection.

Chemical defense and chemical variation in some tropical Pacific species of Halimeda (Halimedaceae; Chlorophyta)

NASA Astrophysics Data System (ADS)

Paul, Valerie J.; van Alstyne, Kathryn L.

1988-03-01

Over a dozen species of the genus Halimeda have been chemically investigated and found to produce the diterpenoid metabolites halimedatrial (1) and halimedatetraacetate (2) in varying concentrations. These meabolites have been proposed to play a role in chemical defense against herbivores based on their chemical structures and their demonstrated biological activities in laboratory and aquarium assays. We examined and compared the feeding deterrent effects of these two compounds tovard herbivorous fishes in field experiments on Guam reefs. Halimedatrial is a more effective feeding deterrent than halimedatetraacetate. It is the major secondary metabolite in young Halimeda macroloba and in the newly produced segments of growing plants. The organic extracts from young plants and new segments were significantly more deterrent than extracts from mature plant tissue. Some populations of Halimeda growing in reef-slope habitats, where herbivory is intense, also have high concentrations of halimedatrial. We compared extracts between reef slope and reef flat collections of Halimeda opuntia on Guam and Pohnpei (= Ponape), and H. discoidea and H. macroloba on Guam. We found that halimedtrial was the major metabolite in reef-slope collections of H. opuntia from Pohnpei and Pago Bay, Guam, and that halimedatetraacetate was the major metabolite a non-reef slope populations. In the cases examined, chemical defenses were greatest in (1) plant parts and (2) populations that were at greatest risk to herbivores.

Penny-Wise, Dollar-Foolish.

ERIC Educational Resources Information Center

Griffin, C. W.

1979-01-01

A veteran energy author discusses the economic deterrents to energy-conservation design measures inherent in the present tax laws, and proposes a standard energy tax reduction as a potential solution. (Author)

An Assessment of the U.S. Peacekeeping Training in West Africa: Is it on the Road to Stability?

DTIC Science & Technology

2003-01-01

iv ACKNOWLEDGMENTS First I would like to thank MAJ John Silkman for steering me towards the topic of the African Crisis Response Initiative; I would...Leone, Togo, and Burkina Faso ( Schiavone 1993, 89-93). Economic Community of West Africa Monitoring Group (ECOMOG): A peacekeeping body within ECOWAS...operations. It forms the base for all regional West African peacekeeping operations ( Schiavone 1993, 92-93). Executive Outcomes: One of the better known

South Asian Stability Workshop: A Crisis Simulation Exercise

DTIC Science & Technology

2013-10-01

cricket  match  in  Jaipur  in  November  2018   that  kills  the  Indian  defense  minister...event  was  as  follows.   On  Thursday,  November  22,  2018,  a   cricket  match  is  held  between  India  and...killed  include  a  Pakistani  singer,  an  Indian   actress,  and   cricketers  on  both  teams.   Four

Civilian Skills for African Military Officers to Resolve the Infrastructure, Economic Development, and Stability Crisis in Sub-Saharan Africa

DTIC Science & Technology

2011-03-01

AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Army War College,Strategic... projects build - ing Chinese infrastructure in both rural and urban ar- eas.53 The Chinese model thus instills a lifelong dedica- tion to and...Studies Institute,122 Forbes Avenue,Carlisle,PA,17013 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES

Pheochromocytoma Crisis With Severe Cyclic Blood Pressure Fluctuations in a Cardiac Pheochromocytoma Patient Successfully Resuscitated by Extracorporeal Membrane Oxygenation

PubMed Central

Zhou, Xiang; Liu, Dawei; Su, Longxiang; Long, Yun; Du, Wei; Miao, Qi; Li, Fang; Jin, Zhengyu; Zeng, Zhengpei; Luo, Ailun; Huang, Yuguang

2015-01-01

Abstract Cardiac pheochromocytoma is relatively rare. Few reports describe the intraoperative and postoperative progression of patients experiencing a life-threatening pheochromocytoma crisis treated with extracorporeal membrane oxygenation (ECMO). A 35-year-old man was referred to our facility for paroxysmal hypertension with a 10-year history of sweating, headaches, cardiac palpitations, and postexercise dyspnea. The patient initially underwent urine catecholamine measurement and an isotope scan, somatostatin receptor scintigraphy, and 18F-fluorodeoxyglucose positron emission tomography/computer tomography (CT), which indicated a multiple, cardiac pheochromocytoma. Echocardiography, cardiac magnetic resonance imaging (MRI), CT reconstruction, and a coronary CT angiography revealed several lesions at the aortic root and along the cardiac vasculature. Multifocal cardiac pheochromocytoma was diagnosed and pheochromocytoma crisis with severe cyclic blood pressure fluctuation occurred during surgery. Surgical resection of multiple pheochromocytomas in the right medial carotid sheath, mediastinum between the main and pulmonary arteries, and between the abdominal aorta and inferior vena artery was performed. To ensure cardiac perfusion and avoid severe circulatory fluctuation, the cardiac paraganglioma resection was prioritized. After resecting the cardiac pheochromocytoma, a severe pheochromocytoma crisis with rapid cyclic blood pressure fluctuation developed. ECMO and intraaortic balloon pump (IABP) were initiated to stabilize circulation and perfusion. Phenoxybenzamine, norepinephrine, epinephrine, and fluid resuscitation were administered to support cardiovascular function. The magnitude of blood pressure fluctuation steadily decreased with treatment. IABP was discontinued after 3 days, and ECMO was discontinued after 16 days. The patient was discharged 3 months postoperatively. This case indicates that mechanical life support with ECMO is a valuable option for pheochromocytoma-induced cardiac shock and should be considered as an effective therapeutic choice in patients with highly unstable hemodynamic function. PMID:25929929

Assurance Penalty Level Analysis Final Rule TSD

EPA Pesticide Factsheets

This Technical Support Document (TSD) supports EPA’s determination that the final Transport Rule’s assurance provision penalty requirement provides sufficient deterrence against a state exceeding its assurance level.

Stockpile Stewardship: How We Ensure the Nuclear Deterrent Without Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2014-09-04

In the 1990s, the U.S. nuclear weapons program shifted emphasis from developing new designs to dismantling thousands of existing weapons and maintaining a much smaller enduring stockpile. The United States ceased underground nuclear testing, and the Department of Energy created the Stockpile Stewardship Program to maintain the safety, security, and reliability of the U.S. nuclear deterrent without full-scale testing. This video gives a behind the scenes look at a set of unique capabilities at Lawrence Livermore that are indispensable to the Stockpile Stewardship Program: high performance computing, the Superblock category II nuclear facility, the JASPER a two stage gas gun,more » the High Explosive Applications Facility (HEAF), the National Ignition Facility (NIF), and the Site 300 contained firing facility.« less

Los Alamos National Laboratory Human and Intellectual Capital for Sustaining Nuclear Deterrence

DOE Office of Scientific and Technical Information (OSTI.GOV)

McAlpine, Bradley

2015-04-01

This paper provides an overview of the current human and intellectual capital at Los Alamos National Laboratory, through specific research into the statistics and demographics as well as numerous personal interviews at all levels of personnel. Based on this information, a series of recommendations are provided to assist Los Alamos National Laboratory in ensuring the future of the human and intellectual capital for the nuclear deterrence mission. While the current human and intellectual capital is strong it stands on the precipice and action must be taken to ensure Los Alamos National Laboratory maintains leadership in developing and sustaining national nuclearmore » capabilities. These recommendations may be applicable to other areas of the nuclear enterprise, including the Air Force, after further research and study.« less

Confidence in Nuclear Weapons as Numbers Decrease and Time Since Testing Increases

NASA Astrophysics Data System (ADS)

Adams, Marvin

2011-04-01

As numbers and types of nuclear weapons are reduced, the U.S. objective is to maintain a safe, secure and effective nuclear deterrent without nuclear-explosive testing. A host of issues combine to make this a challenge. An evolving threat environment may prompt changes to security systems. Aging of weapons has led to ``life extension programs'' that produce weapons that differ in some ways from the originals. Outdated and changing facilities pose difficulties for life-extension, surveillance, and dismantlement efforts. A variety of factors can make it a challenge to recruit, develop, and retain outstanding people with the skills and experience that are needed to form the foundation of a credible deterrent. These and other issues will be discussed in the framework of proposals to reduce and perhaps eliminate nuclear weapons.

Received and perceived social support in times of stress: a test of the social support deterioration deterrence model.

PubMed

Norris, F H; Kaniasty, K

1996-09-01

The authors evaluated the impact of receiving social support on subsequent levels of perceived social support and psychological distress in 2 independent samples of victims of severe natural disasters: Hurricane Hugo (n = 498) and Hurricane Andrew (n = 404). A social support deterioration deterrence model was proposed that stipulated that postdisaster mobilization of received support counteracts the deterioration in expectations of support often experienced by victims of major life events. LISREL analyses of data collected 12 and 24 months after Hugo and 6 and 28 months after Andrew provided strong evidence for the hypothesized model: Perceived support mediated the long-term effects on distress of both scope of disaster exposure and postdisaster received support. Theoretical and application issues of social support are discussed.

Chrysolina herbacea Modulates Terpenoid Biosynthesis of Mentha aquatica L.

PubMed Central

Atsbaha Zebelo, Simon; Bertea, Cinzia M.; Bossi, Simone; Occhipinti, Andrea; Gnavi, Giorgio; Maffei, Massimo E.

2011-01-01

Interactions between herbivorous insects and plants storing terpenoids are poorly understood. This study describes the ability of Chrysolina herbacea to use volatiles emitted by undamaged Mentha aquatica plants as attractants and the plant's response to herbivory, which involves the production of deterrent molecules. Emitted plant volatiles were analyzed by GC-MS. The insect's response to plant volatiles was tested by Y-tube olfactometer bioassays. Total RNA was extracted from control plants, mechanically damaged leaves, and leaves damaged by herbivores. The terpenoid quantitative gene expressions (qPCR) were then assayed. Upon herbivory, M. aquatica synthesizes and emits (+)-menthofuran, which acts as a deterrent to C. herbacea. Herbivory was found to up-regulate the expression of genes involved in terpenoid biosynthesis. The increased emission of (+)-menthofuran was correlated with the upregulation of (+)-menthofuran synthase. PMID:21408066

Peace and war: a study of morality and US strategic nuclear policies. Study project report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ginder, D.B.; Hicks, I.

1983-05-01

The paper examines the quesitons of peace and war and the morality of nuclear deterrence. These vital and enduring questions have been again become a focus of societal debate, especially in the light of the Catholic Bishop's pastoral letter. The nuclear debate is all encompassing, raising philosophical, political, social, strategic an religious questions. These issues present problems that each informed citizen will have to discern both morally and politically. The purpose of the paper is not to evaluate the morality of the defense and deterrent policies/strategies of the United States, but to provide the reader with the information to allowmore » him to formulate judgment on this important question and be able to reconcile personal moral values with national policy and strategy.« less

The health migration crisis: the role of four Organisation for Economic Cooperation and Development countries.

PubMed

Pond, Bob; McPake, Barbara

2006-04-29

The crisis of human resources for health that is affecting low-income countries and especially sub-Saharan Africa has been attributed, at least in part, to increasing rates of migration of qualified health staff to high-income countries. We describe the conditions in four Organisation for Economic Cooperation and Development (OECD) health labour markets that have led to increasing rates of immigration. Popular explanations of these trends include ageing populations, growing incomes, and feminisation of the health workforce. Although these explanations form part of the larger picture, analysis of the forces operating in the four countries suggests that specific policy measures largely unrelated to these factors have driven growing demand for health staff. On this basis we argue that specific policy measures are equally capable of reversing these trends and avoiding the exploitation of low-income countries' scarce resources. These policies should seek to ensure local stability in health labour markets so that shortages of staff are not solved via the international brain drain.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weiss, K G

The end of the Cold War seemed to create a more peaceful international environment. September 11 reminded us of the dangers of complacency. Indeed, even before September 11 US forces had intervened in a number of wars and crises, including Panama, the Persian Gulf War, Somalia, Rwanda, Bosnia, Kosovo, several Taiwan Straits crises, the North Korea nuclear weapons crisis, and most recently Afghanistan. US ability to intervene in remote areas of the world is often dependent on the Navy's ability to project power ashore. As a result, US ability to influence events in crisis situations, especially between or among nuclearmore » powers, may become more difficult along with our ability to conduct littoral warfare. Although the numbers of potentially hostile submarines have declined with the end of the Cold War, US anti-submarine warfare capabilities have also declined. Moreover, foreign submarines and related technologies are likely to diffuse globally. New technologies like Air Independent Propulsion (AIP), improved weapons and sensors will make conventional submarines more dangerous, and the spread of nuclear submarines even to a few more countries raise political, military, environmental, and safety concerns. Submarines are one of the key weapon systems used alone or in combination with other weapon systems such as coastal defense missiles, aircraft, and other sea-based missile platforms to deny US ability to project power ashore, Thus, other countries who wish to deny the US the ability to interfere with their regional or even global ambitions may emphasize the acquisition and/or development of submarines. As the world become more multipolar over the longer term, as the Chinese believe it will, countries such as Russia, China. etc., may be able to acquire the submarine capabilities to challenge us not just regionally, but in blue waters. To the extent that our alliance relationships require US naval access or superiority to sustain them, then our erstwhile friendly allies such as Japan, South Korea, ASEAN states, Taiwan, etc., may seek their own arrangements with other powers for their protection or seek WMD capabilities to offset the former reliance on the US. In addition to a loss of unchallenged regional access, the US may have to devote greater resources for protecting its homeland, and perhaps its sea-based deterrent, from hostile submarine forces.« less

Nuclear Weapons and Science Education.

ERIC Educational Resources Information Center

Wellington, J. J.

1984-01-01

Provides suggestions on how science teachers can, and should, deal with the nuclear weapons debate in a balanced and critical way. Includes a table outlining points for and against deterrence and disarmament. (JN)

How to Reduce Those Costly School Bus Accidents.

ERIC Educational Resources Information Center

Farmer, Ernest

1985-01-01

The deterrent to school bus accidents is preparedness. Training programs for drivers and mechanics, equipment specifications, and a community support base are some of the ways to prevent tragedy. (MLF)

Targets of opportunity : community based alcohol programs

DOT National Transportation Integrated Search

1988-04-01

Targets of Opportunity (TOP), were comprehensive community based programs addressing the drinking and driving concerns within a particular community. The program incorporated six elements: 1) General deterrence - public information,leducation and enf...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swift, Alicia L.

There is no better time than now to close the loophole in Article IV of the Nuclear Non-proliferation Treaty (NPT) that excludes military uses of fissile material from nuclear safeguards. Several countries have declared their intention to pursue and develop naval reactor technology, including Argentina, Brazil, Iran, and Pakistan, while other countries such as China, India, Russia, and the United States are expanding their capabilities. With only a minority of countries using low enriched uranium (LEU) fuel in their naval reactors, it is possible that a state could produce highly enriched uranium (HEU) under the guise of a nuclear navymore » while actually stockpiling the material for a nuclear weapon program. This paper examines the likelihood that non-nuclear weapon states exploit the loophole to break out from the NPT and also the regional ramifications of deterrence and regional stability of expanding naval forces. Possible solutions to close the loophole are discussed, including expanding the scope of the Fissile Material Cut-off Treaty, employing LEU fuel instead of HEU fuel in naval reactors, amending the NPT, creating an export control regime for naval nuclear reactors, and forming individual naval reactor safeguards agreements.« less

32 CFR 16.3 - Available sentences.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Forces of the United States and of the broad deterrent impact associated with a sentence's effect on... recommendation to suspend, remit, commute or otherwise modify the adjudged sentence in concert with one or more...

International Parental Child Abduction Deterrence Act

THOMAS, 111th Congress

Rep. Holt, Rush [D-NJ-12

2009-07-31

House - 09/14/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Determinants of plasma donation: A review of the literature.

PubMed

Beurel, A; Terrade, F; Lebaudy, J-P; Danic, B

2017-09-01

The major contribution of Human Sciences in the understanding of the whole blood donation behavior has been through the study of individuals' motivations and deterrents to donate. However, if whole blood donation has been very widely studied in the last sixty years, we still know very little about plasma donation in voluntary non-remunerated environments. Yet, the need for plasma-derived products has been strongly increasing for some years, and blood collection agencies have to adapt if they want to meet this demand. This article aims to review the main motivations and deterrents to whole blood donation, and to compare them with those that we already know concerning plasma donation. Current evidence shows similarities between both behaviors, but also differences that indicate a need for further research regarding plasma donation. Copyright © 2017. Published by Elsevier SAS.

Nuclear weapons are illegal threats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyrowitz, E.L.

Challenging Harry Almond's position that nuclear deterrence is workable, the author contends that there is no historical basis for believing that anticipation of the horrors of war will be an effective deterrent. He questions the belief that the nuclear balance of terror has maintained the peace for the past 40 years because an arms race is inherently unstable. The argument that the pursuit of national interests takes precedence over any limitation imposed by international law reflects a perception of international law that is comparable to the Third Reich. The bases for a legal evaluation of the status of nuclear weaponsmore » under international law come from express and implicit treaty provisions, international custom, general principles of international law, judicial decisions, resolutions at the United Nations, and the opinions of qualified jurists as well as military necessity.« less

Improve medical malpractice law by letting health care insurers take charge.

PubMed

Reinker, Kenneth S; Rosenberg, David

2011-01-01

This essay discusses unlimited insurance subrogation (UIS) as a means of improving the deterrence and compensation results of medical malpractice law. Under UIS, health care insureds could assign their entire potential medical malpractice claims to their first-party commercial and government insurers. UIS should improve deterrence by establishing first-party insurers as plaintiffs to confront liability insurers on the defense side, leading to more effective prosecution of meritorious claims and reducing meritless and unnecessary litigation. UIS should improve compensation outcomes by converting litigation cost- and risk- laden "tort insurance" into cheaper and enhanced first-party insurance. UIS also promises dynamic benefits through further reforms by contract between the first-party and liability insurers that would take charge of system. No UIS-related costs are apparent that would outweigh these benefits. © 2011 American Society of Law, Medicine & Ethics, Inc.

Effects of an electric field on white sharks: in situ testing of an electric deterrent.

PubMed

Huveneers, Charlie; Rogers, Paul J; Semmens, Jayson M; Beckmann, Crystal; Kock, Alison A; Page, Brad; Goldsworthy, Simon D

2013-01-01

Elasmobranchs can detect minute electromagnetic fields, <1 nV cm(-1), using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks.

Structure-activity relationship studies on the mosquito toxicity and biting deterrency of callicarpenal derivatives.

PubMed

Cantrell, Charles L; Klun, Jerome A; Pridgeon, Julia; Becnel, James; Green, Solomon; Fronczek, Frank R

2009-04-01

Callicarpenal (=13,14,15,16-tetranorclerod-3-en-12-al=[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethylnaphthalen-1-yl]acetaldehyde; 1) has previously demonstrated significant mosquito bite-deterring activity against Aedes aegypti and Anopheles stephensi in addition to repellent activity against host-seeking nymphs of the blacklegged tick, Ixodes scapularis. In the present study, structural modifications were performed on callicarpenal (1) in an effort to understand the functional groups necessary for maintaining and/or increasing its activity and to possibly lead to more effective insect control agents. All modifications in this study targeted the C(12) aldehyde or the C(3) alkene functionalities or combinations thereof. Mosquito biting deterrency appeared to be influenced most by C(3) alkene modification as evidenced by catalytic hydrogenation that resulted in a compound having significantly less effectiveness than 1 at a test amount of 25 nmol/cm2. Oxidation and/or reduction of the C(12) aldehyde did not diminish mosquito biting deterrency, but, at the same time, none of the modifications were more effective than 1 in deterring mosquito biting. Toxicities of synthesized compounds towards Ae. aegypti ranged from an LD50 value of 2.36 to 40.11 microg per mosquito. Similarly, LD95 values ranged from a low of 5.59 to a high of 104.9 microg.

Convenience, the bane of our existence, and other barriers to donating.

PubMed

Schreiber, George B; Schlumpf, Karen S; Glynn, Simone A; Wright, David J; Tu, Yongling; King, Melissa R; Higgins, Martha J; Kessler, Debra; Gilcher, Ronald; Nass, Catharie C; Guiltinan, Anne M

2006-04-01

To prevent donor loss and improve retention, it is important to understand the major deterrents to blood donation and to identify factors that can be effectively addressed by blood centers. A 30-item self-administered questionnaire was completed in 2003 by 1705 first-time and 2437 repeat US donors who had not donated in 2 to 3 years. Asian, Hispanic, black, and white first-time and repeat donors rated the importance of deterrents to donation in their decision to not return with a 1 to 5 scale. Categorical analysis of variance methods were used to compare the importance of deterrents between first-time and repeat donors of different race or ethnicity. Not having a convenient place to donate was most commonly cited as an important or very important reason for not returning by 32 to 42 percent of first-time and 26 to 43 percent of repeat respondents. Although bad treatment and poor staff skills were less of a barrier than convenience, they were more important for minority donors. Other factors such as physical side effects, foreign travel, or length of the process appeared less important. Inconvenience is a major barrier to donating, suggesting that mobile collections and increased hours of operation might help recapture lapsed donors. The finding that lapsed minority donors were more likely to give bad treatment and poor staff skills as important reasons to not donate is disconcerting in light of the changing donor demographics and increased efforts to recruit these donors.

Does Tribolium brevicornis Cuticular Chemistry Deter Cannibalism and Predation of Pupae?

PubMed Central

Alabi, T; Dean, J; Michaud, JP; Verheggen, F; Lognay, G; Haubruge, E

2011-01-01

The cuticular hydrocarbons of insects are species-specific and often function as semiochemicals. The activity of Tribolium brevicornis cuticular hydrocarbons as feeding deterrents that ostensibly function to prevent pupal cannibalism and predation was evaluated. The cuticular hydrocarbons of T. brevicornis pupae were characterized and flour disk bioassays conducted with individual and combined extract components incorporated into artificial diets on which Tribolium adults fed for six days. Feeding by T. brevicornis and T. castaneum on flour disks containing cuticular extracts of T. brevicornis pupae resulted in reduced consumption and weight loss relative to feeding on control flour disks. In both cases, feeding deterrence indices exceeded 80% suggesting that T. brevicornis cuticular hydrocarbons could function to deter cannibalism and predation of pupae by larvae and adult beetles. Sixteen different cuticular hydrocarbons were identified in T. brevicornis pupal extracts. Eight of the commercially available linear alkanes were tested individually in feeding trials with eight Tribolium species. One compound (C28) significantly reduced the amount of food consumed by three species compared to control disks, whereas the compounds C25, C26, and C27 elicited increased feeding in some species. Four other compounds had no effect on consumption for any species. When four hydrocarbon mixtures were tested for synergistic deterrence on T. brevicornis and T. castaneum, none significantly influenced consumption. Our results indicate that the cuticular chemistry of T. brevicornis pupae could serve to deter predation by conspecific and congeneric beetles. PMID:22224957

Effects of an Electric Field on White Sharks: In Situ Testing of an Electric Deterrent

PubMed Central

Huveneers, Charlie; Rogers, Paul J.; Semmens, Jayson M.; Beckmann, Crystal; Kock, Alison A.; Page, Brad; Goldsworthy, Simon D.

2013-01-01

Elasmobranchs can detect minute electromagnetic fields, <1 nVcm–1, using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks. PMID:23658766

Materials for Photovoltaic Applications

NASA Astrophysics Data System (ADS)

Dimova-Malinovska, Doriana

Energy priorities are changing nowadays. As mankind will probably have to face energy crisis, factors such as energy independence, energy security, stability of energy supply and the variety of energy sources become much more vital these days. Photovoltaics is exceptional compared to other renewable sources of energy due to its wide opportunity to gain energetic and environmental benefits. An overview of the present state of knowledge of the materials aspects of photovoltaic cells will be given, and new semiconductor materials, including nanomaterials, with potential for application in photovoltaic devices will be identified.

21 CFR 14.100 - List of standing advisory committees.

Code of Federal Regulations, 2012 CFR

2012-04-01

... research relevant to such communication to the public by both FDA and other entities. It also facilitates... analgesics, e.g., abuse-deterrent opioids, novel analgesics, and issues related to opioid abuse, and those...

21 CFR 14.100 - List of standing advisory committees.

Code of Federal Regulations, 2013 CFR

2013-04-01

... research relevant to such communication to the public by both FDA and other entities. It also facilitates... analgesics, e.g., abuse-deterrent opioids, novel analgesics, and issues related to opioid abuse, and those...

21 CFR 14.100 - List of standing advisory committees.

Code of Federal Regulations, 2014 CFR

2014-04-01

... research relevant to such communication to the public by both FDA and other entities. It also facilitates... analgesics, e.g., abuse-deterrent opioids, novel analgesics, and issues related to opioid abuse, and those...

Malnutrition: A Deterrent to Human Progress

ERIC Educational Resources Information Center

Johnson, Nancy E.; Found, R. Elaine

1971-01-01

Authors discuss the effects of malnutrition on retardation of mental development and intellectual capacity. Research findings on undernourished experimental animals are cited as well as studies involving children suffering the effects of malnutrition in infancy. (Editor/LF)

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

45 CFR 30.23 - Enforcement policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of deterrence and securing compliance, present and future, will be adequately served by the Secretary's acceptance of the sum to be agreed upon. ... § 30.23 Enforcement policy. The Secretary may compromise statutory penalties, forfeitures, or claims...

Radioactive Import Deterrence Act

THOMAS, 111th Congress

Rep. Gordon, Bart [D-TN-6

2009-01-14

Senate - 12/03/2009 Received in the Senate and Read twice and referred to the Committee on Environment and Public Works. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

Paddling, Punishing and Force

ERIC Educational Resources Information Center

Hyman, Irwin A.; And Others

1977-01-01

Discusses the extent and use of corporal punishment in public schools, the results of research on the effectiveness of corporal punishment as a deterrent to misbehavior, and the use and effect of alternative measures of classroom management. (BF)

Alterations of DNA content in human endometrial stromal cells transfected with a temperature-sensitive SV40: tetraploidization and physiological consequences.

PubMed

Rinehart, C A; Mayben, J P; Butler, T D; Haskill, J S; Kaufman, D G

1992-01-01

The normal genomic stability of human cells is reversed during neoplastic transformation. The SV40 large T antigen alters the DNA content in human endometrial stromal cells in a manner that relates to neoplastic progression. Human endometrial stromal cells were transfected with a plasmid containing the A209 temperature-sensitive mutant of SV40 (tsSV40), which is also defective in the viral origin of replication. Ninety-seven clonal transfectants from seven different primary cell strains were isolated. Initial analysis revealed that 20% of the clonal populations (19/97) had an apparent diploid DNA content, 35% (34/97) had an apparent tetraploid DNA content, and the remainder were mixed populations of diploid and tetraploid cells. No aneuploid populations were observed. Diploid tsSV40 transformed cells always give rise to a population of cells with a tetraploid DNA content when continuously cultured at the permissive temperature. The doubling of DNA content can be vastly accelerated by the sudden reintroduction of large T antigen activity following a shift from non-permissive to permissive temperature. Tetraploid tsSV40 transfected cells have a lower capacity for anchorage-independent growth and earlier entry into 'crisis' than diploid cells. These results indicate that during the pre-crisis, extended lifespan phase of growth, the SV40 large T antigen causes a doubling of DNA content. This apparent doubling of DNA content does not confer growth advantage during the extended lifespan that precedes 'crisis'.

Governing the resilience of neoliberalism through biopolitics

PubMed Central

Mavelli, Luca

2016-01-01

Neoliberalism is widely regarded as the main culprit for the 2007/2008 global financial crisis. However, despite this abysmal failure, neoliberalism has not merely survived the crisis, but actually ‘thrived’. How is it possible to account for the resilience of neoliberalism? Existing scholarship has answered this question either by focusing on the distinctive qualities of neoliberalism (such as adaptability, internal coherence and capacity to incorporate dissent) or on the biopolitical capacity of neoliberalism to produce resilient subjects. This article adopts a different perspective. Drawing on and partially challenging the perspective of Michel Foucault, I argue that neoliberalism and biopolitics should be considered two complementary governmental rationalities, and that biopolitical rationalities contribute to governing the uncertainties and risks stemming from the neoliberalization of life. Biopolitics, in other words, plays a key role in governing the resilience of neoliberalism. Through this conceptual lens, the article explores how biopolitical rationalities of care have been deployed to govern the neoliberal crisis of the Greek sovereign debt, which threatened the stability of the European banking system and, I shall argue, the neoliberal life, wealth and well-being of the European population. The article discusses how biopolitical racism is an essential component of the biopolitical governance of neoliberalism. Biopolitical racism displaces the sources of risk, dispossession and inequality from the neoliberal regime to ‘inferior’ populations, whose lack of compliance with neoliberal dictates is converted into a threat to our neoliberal survival. This threat deserves punishment and authorizes further dynamics of neoliberal dispossession. PMID:29278249

Governing the resilience of neoliberalism through biopolitics.

PubMed

Mavelli, Luca

2017-09-01

Neoliberalism is widely regarded as the main culprit for the 2007/2008 global financial crisis. However, despite this abysmal failure, neoliberalism has not merely survived the crisis, but actually 'thrived'. How is it possible to account for the resilience of neoliberalism? Existing scholarship has answered this question either by focusing on the distinctive qualities of neoliberalism (such as adaptability, internal coherence and capacity to incorporate dissent) or on the biopolitical capacity of neoliberalism to produce resilient subjects. This article adopts a different perspective. Drawing on and partially challenging the perspective of Michel Foucault, I argue that neoliberalism and biopolitics should be considered two complementary governmental rationalities, and that biopolitical rationalities contribute to governing the uncertainties and risks stemming from the neoliberalization of life. Biopolitics, in other words, plays a key role in governing the resilience of neoliberalism. Through this conceptual lens, the article explores how biopolitical rationalities of care have been deployed to govern the neoliberal crisis of the Greek sovereign debt, which threatened the stability of the European banking system and, I shall argue, the neoliberal life, wealth and well-being of the European population. The article discusses how biopolitical racism is an essential component of the biopolitical governance of neoliberalism. Biopolitical racism displaces the sources of risk, dispossession and inequality from the neoliberal regime to 'inferior' populations, whose lack of compliance with neoliberal dictates is converted into a threat to our neoliberal survival. This threat deserves punishment and authorizes further dynamics of neoliberal dispossession.

Deterrence of the drinking driver : an international survey

DOT National Transportation Integrated Search

1981-03-01

The report surveys the international literature on drinking-and-driving laws to determine what is known concerning their impact on driver behavior. Its particular concern is with reported adoptions of Scandinavian-type laws, which define the drinking...

Prevention and Deterrence of Crimes Against Children Act of 2009

THOMAS, 111th Congress

Rep. Scalise, Steve [R-LA-1

2009-07-31

House - 09/14/2009 Referred to the Subcommittee on Immigration, Citizenship, Refugees, Border Security, and International Law. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

NNSA Administrator Looks to Future of Nuclear Security at STRATCOM Symposium

ScienceCinema

Thomas D'Agostino

2017-12-09

Administrator Thomas P. DAgostino of the National Nuclear Security Administration (NNSA) discusses the future of the Nuclear Security Enterprise and its strategic deterrence mission in light of President Obamas unprecedented nuclear security agenda.

Bird nesting and droppings control on highway structures.

DOT National Transportation Integrated Search

2010-10-01

This report provides a comprehensive literature survey of permanent and temporary deterrents to nesting and roosting, a : discussion of risks to human health and safety from exposure to bird nests and droppings and recommended protective measures, : ...

Facing Up to the Issues.

ERIC Educational Resources Information Center

Wakefield, Rowan; And Others

1984-01-01

Major long-term issues that will have to be addressed by the president and Congress are discussed. These include the changing American family, America's growing international debt, changing trends in agribusiness, industrial policy, and nuclear weapons and strategic deterrence. (RM)

Crash test and evaluation of locking architectural mailboxes.

DOT National Transportation Integrated Search

2014-09-01

Some homeowners and businesses are becoming increasingly concerned about mail-identity theft. : Consequently, there is a growing demand for the use of locking mailboxes for theft deterrence and vandal : resistance. There are a number of mailbox produ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

48 CFR 32.107 - Need for contract financing not a deterrent.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contractor's need for contract financing as a handicap for a contract award; e.g., as a responsibility factor... because the contractor failed to indicate a need for contract financing before the contract was awarded. ...

School discipline and disruptive classroom behavior: the moderating effects of student perceptions.

PubMed

Way, Sandra M

2011-01-01

This study examines the relationship between school discipline and student classroom behavior. A traditional deterrence framework predicts that more severe discipline will reduce misbehavior. In contrast, normative perspectives suggest that compliance depends upon commitment to rules and authority, including perceptions of fairness and legitimacy. Using school and individual-level data from the National Education Longitudinal Study of 1988 and multilevel regression modeling, the author finds support for the normative perspective. Students who perceive school authority as legitimate and teacher–student relations as positive are rated as less disruptive. While perceptions of fairness also predict lower disruptions, the effects are mediated by positive teacher–student relations. Contrary to the deterrence framework, more school rules and higher perceived strictness predicts more, not less, disruptive behavior. In addition, a significant interaction effect suggests that attending schools with more severe punishments may have the unintended consequence of generating defiance among certain youth.

Deterrence and transmission as mechanisms ensuring reliability of gossip.

PubMed

Giardini, Francesca

2012-10-01

Spreading information about the members of one's group is one of the most universal human behaviors. Thanks to gossip, individuals can acquire the information about their peers without sustaining the burden of costly interactions with cheaters, but they can also create and revise social bonds. Gossip has also several positive functions at the group level, promoting cohesion and norm compliance. However, gossip can be unreliable, and can be used to damage others' reputation or to circulate false information, thus becoming detrimental to people involved and useless for the group. In this work, we propose a theoretical model in which reliability of gossip depends on the joint functioning of two distinct mechanisms. Thanks to the first, i.e., deterrence, individuals tend to avoid informational cheating because they fear punishment and the disruption of social bonds. On the other hand, transmission provides humans with the opportunity of reducing the consequences of cheating through a manipulation of the source of gossip.

Education in Anti-Doping: The Art of Self-Imposed Constraints.

PubMed

Loland, Sigmund

2017-01-01

The pillars of anti-doping are detection, deterrence, and prevention. Detection takes the form of testing for banned substances. Deterrence builds on testing and gathering evidence. Athletes who test positive are exposed to penalties. The main tool of prevention is education. Education takes many forms and can be implemented in many ways. This chapter addresses the nature and challenges of current anti-doping education. Firstly, general goals of education and their connection to sport are discussed. Secondly, three normative interpretations of sport are presented, and their implications for anti-doping education are examined. Instrumentalist interpretations and interpretations with emphasis on performance and enhancement challenge the anti-doping campaign. A human excellence interpretation is advocated in which anti-doping is considered a consistent and integral part of sport. Thirdly, future challenges for anti-doping education are reflected upon. © 2017 S. Karger AG, Basel.

Nuclear weapons and medicine: some ethical dilemmas.

PubMed

Haines, A; de B White, C; Gleisner, J

1983-12-01

The enormous destructive power of present stocks of nuclear weapons poses the greatest threat to public health in human history. Technical changes in weapons design are leading to an increased emphasis on the ability to fight a nuclear war, eroding the concept of deterrence based on mutually assured destruction and increasing the risk of nuclear war. Medical planning and civil defence preparations for nuclear war have recently been increased in several countries although there is little evidence that they will be of significant value in the aftermath of a nuclear conflict. These developments have raised new ethical dilemmas for those in health professions. If there is any risk of use of weapons of mass destruction, then support for deterrence with these weapons as a policy for national or global security appears to be incompatible with basic principles of medical ethics and international law. The primary medical responsibility under such circumstances is to participate in attempts to prevent nuclear war.

Strategic command, control, communications, and intelligence.

PubMed

Zraket, C A

1984-06-22

Command, control, communications, and intelligence (C(3)l) for nuclear forces are essential elements in the deterrence of nuclear war. The present C(3)l) system has vulnerabilities associated with its reliability, survivability, and endurance under attack, thereby weakening deterrence by increasing the ambiguity in our capabilities. Development of a reliable and enduring C(3)l) system would reduce this ambiguity. Its reliable, positive control of nuclear forces would give the national leadership more time to assess situations, ensure discriminate retaliation, and improve our ability to manage crises in general. These capabilities could help to stop a war rapidly should one start. A reliable and enduring C(3)1) system will be needed for a long time to come, even if a freeze on strategic nuclear forces is accomplished or other arms control successes achieved. Indeed, C(3)l) may be the best source today of confidence-building measures to reduce tensions and the threat of nuclear catastrophe.

Recurrent issues in efforts to prevent homicidal youth violence in schools: expert opinions.

PubMed

Dill, Karen E; Redding, Richard E; Smith, Peter K; Surette, Ray; Cornell, Dewey G

2011-01-01

Developmental research on social influences on adolescents can guide practices aimed to prevent homicidal youth violence. School shootings have repeatedly raised questions about the contributory role of bullying and entertainment violence, how news media publicity might produce copycat crimes, and whether stiffer criminal sanctions might have a deterrent effect. This article presents the thoughts and recommendations of a group of experts on these topics summarizing the current knowledge base. In brief, bullying reduction programs may be a useful early prevention effort. Television and video games with violent themes can encourage aggressive behavior, but these media can be used to teach more prosocial behavior as well. The potential copycat effects of highly publicized crimes might be diminished with more restrained reporting, although more research is needed. Finally, there is substantial evidence that increased criminal sanctions for youthful offenders have not had a deterrent effect. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.

Suicide, unemployment, and economic recession in Spain.

PubMed

Iglesias-García, Celso; Sáiz, Pilar A; Burón, Patricia; Sánchez-Lasheras, Fernando; Jiménez-Treviño, Luis; Fernández-Artamendi, Sergio; Al-Halabí, Susana; Corcoran, Paul; García-Portilla, M Paz; Bobes, Julio

The aim of the present work is to determine the association between unemployment and suicide, and to investigate whether this association is affected by changes in the economic cycle or other variables such as age and sex. A time-trend analysis was conducted to study changes in the number of suicides between 1999 and 2013 in Spain. Pearson's correlation coefficients and regression models were used to find the association between unemployment and suicide. A significant positive association was found between unemployment and suicide in the pre-crisis period in men. In that period (1999-2007), each 1% annual increase in unemployment was associated with a 6.90% increase in the annual variation of suicide in the total population, and with a 9.04% increase in the annual variation of suicide in working age men. The correlation between unemployment and suicide is significant in periods of economic stability, but has weakened during the recent financial crisis. Unemployment and suicide have a complex relationship modulated by age, sex and economic cycle. Copyright © 2017 SEP y SEPB. Publicado por Elsevier España, S.L.U. All rights reserved.

"Selling smarter, not harder": Life course effects on drug sellers' risk perceptions and management.

PubMed

Fader, Jamie J

2016-10-01

Policies undergirding the American War on Drugs assume that drug offenders respond rationally to adjustments in sanction certainty and severity. Previous studies find that instead of absolute deterrence, or the termination of criminal activity, drug offenders employ restrictive deterrence, or a variety of risk management strategies. Extant research and current drug policy both fail to examine the interaction of risk perception, management techniques, and life course events or circumstances. This dynamic examination of apprehension avoidance strategies relies on in-depth interviews mapping out the careers of 20 drug sellers in Philadelphia, Pennsylvania. It examines their risk perceptions and risk management strategies and techniques, exploring rationales for shifts in offending behavior. Respondents were highly risk-averse but used a narrow definition of sanctions relevant to shaping future offending behavior, typically making small adjustments in sales techniques. Rationales for these shifts included sanctions, personal preference, and life course events or circumstances. Only one attributed lasting desistance from offending to a sanction, although life course events such as parenthood and employment were associated with short-term and planned desistance. The limited relevance of sanctions to offenders' thinking about risk avoidance contextualizes the widespread failure of policies designed to deter drug sales. Findings support a growing conclusion that severity of punishment is a less powerful deterrent than certainty and that adjustments in certainty after arrest are offense-specific. The relationship of life course events - especially employment - to desistance and resumed offending suggest that social policies may be more effective than criminal justice sanctions in reducing drug offending. Copyright © 2016 Elsevier B.V. All rights reserved.

On international fisheries agreements, entry deterrence, and ecological uncertainty.

PubMed

Ellefsen, Hans; Grønbæk, Lone; Ravn-Jonsen, Lars

2017-05-15

A prerequisite for an international fisheries agreement (IFA) to be stable is that parties expect the benefits from joining the agreement to exceed the benefits from free riding on the agreement, and parties only comply with the agreement as long as this is true. The agreement, therefore, implicitly builds on an expectation of the ecological condition of the natural resource. Game theoretical models often assume that all parties have the same (often perfect) information about the resource and that the exploitation is an equilibrium use of the stock. As stated by experts in natural science, the fish ecology still has many open questions, for example how to predict population dynamics, migration patterns, food availability, etc. In some cases, parties disagree about the state, abundance, and migration of a stock, which can reduce the possibilities of reaching an agreement for exploitation of the stock. This paper develops a model and applies it to the North-East Atlantic mackerel fishery, in order to analyze an IFA under different ecological scenarios, and also combines the model with the economic theory of entry deterrence. The model is used empirically to determine whether the parties with original access to the resource have an advantage when forming an agreement with a new party in having the ability to fish the stock down to a smaller size and thereby prevent another party from entering into the fishery. With a basis in entry deterrence, combined with lack of information, the paper illustrates the obstacles that have made an agreement for the North-East Atlantic mackerel so difficult to achieve. Copyright © 2017 Elsevier Ltd. All rights reserved.

Deterrence and nuclear strategy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lodal, J.M.

1980-01-01

Mr. Lodal sees the social aspects of an effective deterrence policy as no less important than its technological aspects; further, programs and policies must be put in place that enhance social cohesion, that demonstrate the will to carry through on the strategy that we in the Western world subscribe to. It is the challenge of this political objective that most demands our attention. He feels that, if we are to remain secure, we must restore not only political cohesion to the Western alliance but a sensible political relationship between the United States and the Soviet Union as well. Such amore » relationship will of necessity provide for arms control. If we are able to maintain the arms control agreements reached to date, including the ABM treaty and SALT II, we will be a step ahead. It is to be hoped that the administration taking office in January of 1981 can restore order to our political relationships and avoid the necessity of a major defense program change such as the one suggested here. Unfortunately, the risk of this not happening is very real, according to Mr. Lodal. Therefore, the conceptualizing of concrete policies to improve our strategic nuclear posture becomes imperative. Adding limited defenses to our traditional doctrine is simply the best of a set of difficult choices. Such defenses would make our threatened use of battlefield nuclear weapons more credible, and they would restore a measure of extended deterrence; battlefield weapons could be used with the knowledge that only a massive Soviet attack would harm the US homeland. Thus, the defense would create a second firebreak in the ladder of escalation.« less

Regime shifts and panarchies in regional scale social-ecological water systems

PubMed Central

Gunderson, Lance; Cosens, Barbara A.; Chaffin, Brian C.; (Tom) Arnold, Craig A.; Fremier, Alexander K.; Garmestani, Ahjond S.; Craig, Robin Kundis; Gosnell, Hannah; Birge, Hannah E.; Allen, Craig R.; Benson, Melinda H.; Morrison, Ryan R.; Stone, Mark C.; Hamm, Joseph A.; Nemec, Kristine; Schlager, Edella; Llewellyn, Dagmar

2018-01-01

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises, but may also facilitate recovery; and constrain system transformation, but may also provide windows of opportunity in which transformation, and the resources to accomplish it, may occur. The framework is the starting point for our exploration of how law might play a role in enhancing the capacity of social-ecological systems to adapt to climate change. PMID:29780427

Regime shifts and panarchies in regional scale social-ecological water systems.

PubMed

Gunderson, Lance; Cosens, Barbara A; Chaffin, Brian C; Tom Arnold, Craig A; Fremier, Alexander K; Garmestani, Ahjond S; Craig, Robin Kundis; Gosnell, Hannah; Birge, Hannah E; Allen, Craig R; Benson, Melinda H; Morrison, Ryan R; Stone, Mark C; Hamm, Joseph A; Nemec, Kristine; Schlager, Edella; Llewellyn, Dagmar

2017-03-17

In this article we summarize histories of nonlinear, complex interactions among societal, legal, and ecosystem dynamics in six North American water basins, as they respond to changing climate. These case studies were chosen to explore the conditions for emergence of adaptive governance in heavily regulated and developed social-ecological systems nested within a hierarchical governmental system. We summarize resilience assessments conducted in each system to provide a synthesis and reference by the other articles in this special feature. We also present a general framework used to evaluate the interactions between society and ecosystem regimes and the governance regimes chosen to mediate those interactions. The case studies show different ways that adaptive governance may be triggered, facilitated, or constrained by ecological and/or legal processes. The resilience assessments indicate that complex interactions among the governance and ecosystem components of these systems can produce different trajectories, which include patterns of (a) development and stabilization, (b) cycles of crisis and recovery, which includes lurches in adaptation and learning, and (3) periods of innovation, novelty, and transformation. Exploration of cross scale (Panarchy) interactions among levels and sectors of government and society illustrate that they may constrain development trajectories, but may also provide stability during crisis or innovation at smaller scales; create crises, but may also facilitate recovery; and constrain system transformation, but may also provide windows of opportunity in which transformation, and the resources to accomplish it, may occur. The framework is the starting point for our exploration of how law might play a role in enhancing the capacity of social-ecological systems to adapt to climate change.