[Palliative medicine content in German-language medical textbooks].

PubMed

Becker, G; Dausch, V; Xander, C; Olschewski, M; Momm, F; Blum, H E

2007-02-09

There is a need for improved end-of-life care, especially in the light of demographic changes with an increased incidence of cancer. Although medical textbooks are central to the training of medical students and also serve as a reference for more experienced clinicians, only few data exist on the extent to which medical textbooks address end-of-life care. We analysed the quantity and quality of information on end-of-life care given in German textbooks on different medical disciplines. 26 top-selling German medical textbooks were analysed for the presentation of end-of-life care in chapters that address the 13 most common causes of death worldwide In the 159 chapters analysed for information on traditional topics, like risk factors or early diagnosis (group A), such information was provided in 52% compared with only 9% on end-of-life topics, such as symptom management or manner of death (group B) (p=0.0001). There was no statistically significant difference between the different medical specialities (p=0.22). Line-by-line analysis showed that the phrase death or related terms was mentioned in only 57 of 159 chapters dealing with the most common causes of death worldwide. The top-selling German textbooks that were analysed generally offer little helpful information on end-of-life care of patients.

What's the Harm? The Coverage of Ethics and Harm Avoidance in Research Methods Textbooks

ERIC Educational Resources Information Center

Dixon, Shane; Quirke, Linda

2018-01-01

Methods textbooks play a role in socializing a new generation of researchers about ethical research. How do undergraduate social research methods textbooks portray harm, its prevalence, and ways to mitigate harm to participants? We conducted a content analysis of ethics chapters in the 18 highest-selling undergraduate textbooks used in sociology…

Mapping the Knowledge Topography: A Critical Appraisal of Geography Textbook Questions

ERIC Educational Resources Information Center

Mishra, Rishabh Kumar

2015-01-01

Textbook questions and exercises are quintessential part of every textbook. One can easily locate textbook questions at the end of the every chapter and also in between the texts. What are they meant for? Usually we think they are meant for assessing learners' understanding regarding subject knowledge, providing clue to teacher to form other…

"Essential Principles of Economics:" A Hypermedia Textbook.

ERIC Educational Resources Information Center

McCain, Roger A.

2000-01-01

Discusses an electronic textbook called "Essential Principles of Economics." Explains that economic concepts are found by following links from the table of contents, while each chapter includes both expository information and interactive material including online multiple-choice drill questions. States that the textbook is a "work…

Physics Textbooks Presentation of the Energy-Conservation Principle in Hydrodynamics

ERIC Educational Resources Information Center

Ibanez, M.; Ramos, M. C.

2004-01-01

The purpose of this study is to determine how energy-conservation principle is exposed in hydrodynamics chapters of university physics textbooks. Ten physics textbooks analyzed show considerable deficiencies in the use of energy concepts related to uncompressible fluid dynamics. The following problems have been extensively found: The pressure…

End-of-life care content in 50 textbooks from multiple specialties.

PubMed

Rabow, M W; Hardie, G E; Fair, J M; McPhee, S J

2000-02-09

Prior reviews of small numbers of medical textbooks suggest that end-of-life care is not well covered in textbooks. No broad study of end-of-life care content analysis has been performed on textbooks across a wide range of medical, pediatric, psychiatric, and surgical specialties. To determine the quantity and rate the adequacy of information on end-of-life care in textbooks from multiple medical disciplines. DESIGN AND SOURCES: A 1998 review of 50 top-selling textbooks from multiple specialties (cardiology, emergency medicine, family and primary care medicine, geriatrics, infectious disease and acquired immunodeficiency syndrome [AIDS], internal medicine, neurology, oncology and hematology, pediatrics, psychiatry, pulmonary medicine, and surgery) for the presence and adequacy of content in 13 end-of-life care domains. Chapters on diseases commonly causing death and those devoted to end-of-life care were identified, read, rated, and compared by textbook specialty, chapter, and domain for the presence of helpful information in the 13 domains. Content for each domain was rated as absent, minimally present, or helpful. Textbook indexes were analyzed for the number of pages relevant to end-of-life care. Overall, helpful information was provided in 24.1% (range, 8.7%-44.2%) of the expected end-of-life content domains; in 19.1% (range, 6.2%-38.5%), expected content received minimal attention; and in 56.9% (range, 23.1 %-77.9%), expected content was absent. As a group, the textbooks with the highest percentages of absent content were in surgery (71.8%), infectious diseases and AIDS (70%), and oncology and hematology (61.9%). Textbooks with the highest percentage of helpful end-of-life care content were in family medicine (34.4%), geriatrics (34.4%), and psychiatry (29.6%). In internal medicine textbooks, the content domains with the greatest amount of helpful information were epidemiology and natural history. Content domains covered least well were social, spiritual, ethical, and family issues, as well as physician after-death responsibilities. On average, textbook indexes cited 2% of their total pages as pertinent to end-of-life care. Top-selling textbooks generally offered little helpful information on caring for patients at the end of life. Most disease-oriented chapters had no or minimal end-of-life care content. Specialty textbooks with information about particular diseases often did not contain helpful information on caring for patients dying from those diseases.

Human Evolution in Science Textbooks from Twelve Different Countries

ERIC Educational Resources Information Center

Quessada, Marie-Pierre; Clement, Pierre; Oerke, Britta; Valente, Adriana

2008-01-01

What kinds of images of human beings illustrate human evolution in school textbooks? A comparison between the textbooks of eighteen different countries (twelve European countries and six non-European countries) was attempted. In six countries (Algeria, Malta, Morocco, Mozambique, Portugal, and Tunisia), we did not find any chapter on the topic of…

Problem Solving in Swedish Mathematics Textbooks for Upper Secondary School

ERIC Educational Resources Information Center

Brehmer, Daniel; Ryve, Andreas; Van Steenbrugge, Hendrik

2016-01-01

The aim of this study is to analyse how mathematical problem solving is represented in mathematical textbooks for Swedish upper secondary school. The analysis comprises dominating Swedish textbook series, and relates to uncovering (a) the quantity of tasks that are actually mathematical problems, (b) their location in the chapter, (c) their…

Applied Developmental Science: An Advanced Textbook. The SAGE Program on Applied Developmental Science

ERIC Educational Resources Information Center

Lerner, Richard M., Ed.; Jacobs, Fraincine, Ed.; Wertlieb, Donald, Ed.

2005-01-01

This course textbook has been adapted from the four-volume "Handbook of Applied Developmental Science" (SAGE 2003), a work that offers a detailed roadmap for action and research in ensuring positive child, youth, and family development. In 20 chapters, "Applied Developmental Science: An Advanced Textbook" brings together theory and application…

An Evaluation of University World Geography Textbook Questions for Components of Spatial Thinking

ERIC Educational Resources Information Center

Scholz, Michael A.; Huynh, Niem Tu; Brysch, Carmen P.; Scholz, Ruojing Wang

2014-01-01

Geography textbooks contain chapter or review questions that may engage students in spatial thinking. This research used Jo and Bednarz's (2009) "Taxonomy of Spatial Thinking" to evaluate the percentage of spatial thinking questions in four university-level world geography course textbooks. The results from this study were then…

Advancing Your Career: Concepts of Professional Nursing. Second Edition.

ERIC Educational Resources Information Center

Kearney, Rose

This textbook, intended for registered nurses (RN's) returning to school, is designed to provide practicing RN's with professional concepts to advance their careers. The book contains 22 chapters organized in five sections. Each chapter includes chapter objectives, key terms, key points, chapter exercises, references, and a bibliography. Section I…

They Still Use Textbooks--Don't They? Selection and Criteria for Evaluation.

ERIC Educational Resources Information Center

Orlich, Donald C., Ed.

This report of a curriculum seminar at Washington State University is focused on the use of textbooks in both schools and libraries. Incorporated within Chapter 1 are topics concerning the textbook industry and how it works, a short discussion of the publishing structure, and information about the developmental costs of both curriculum and…

Mapping the Chapter: One Way to Tackle the CTE Textbook

ERIC Educational Resources Information Center

Laverick DeFelice, Catherine

2010-01-01

This reading specialist has come up with a strategy to help other CTE instructors map the CTE textbook, so that students can better comprehend the information in them and discover a joy of reading. CTE textbooks present a particular challenge because they are packed with information and can be quite different in structure than texts student have…

Discussion of death and dying in surgical textbooks.

PubMed

Easson, A M; Crosby, J A; Librach, S L

2001-07-01

Quality end-of-life care is an increasing concern for the public and the medical profession. Surgical textbooks could serve as an important educational and reference resource to improve this care. Four general surgical textbooks were scored for helpful information on death and dying for eight surgical diseases. For each disease, nine content domains related to care of the dying patient were evaluated. Three texts included a chapter on cancer that was evaluated separately. Disease epidemiology, prognosis/prevention, progression, and medical interventions were generally well discussed in all textbooks. However, little helpful information was provided with regards to breaking bad news/advanced care planning, mode of death, treatment decision-making, effect on family/surgeon, and symptom management. Cancer chapters also addressed only a few of these concerns. Death and the dying patient are sufficiently frequent in surgical practice that it would be appropriate to increase the amount of information provided.

Play a Starring Role in Your Textbook: A Digital Web Platform with an Embedded Role-Playing Game

ERIC Educational Resources Information Center

Spielvogel, Laura; Spielvogel, Christian

2014-01-01

In this report, we introduce our digital e-textbook web platform with an integrated role-playing game, which has been created for "introduction to anthropology" courses. We believe that textbooks have the potential to do more to motivate students' pursuit of learning if their material (topically organised chapters supported by…

Solar Physics and Terrestrial Effects: A Curriculum Guide for Teachers Grades 7-12, 2nd Edition.

ERIC Educational Resources Information Center

Briggs, Roger P.; Carlisle, Robert J.

This curriculum guide includes a brief textbook, a hands-on activity guide, and resource listings. The textbook provides background information in solar physics for teachers and contains problems suitable for advanced students at the end of each chapter. Topics covered in the textbook include stellar evolution, the structure of the sun, methods of…

Inside France: Three Missing Pages from Your Students' Textbook.

ERIC Educational Resources Information Center

Conniffe, Patricia, Ed.

This mini-unit seeks to fill the gap in textbooks that exists when teaching about modern France. Many textbooks end their coverage of France with the chapter on World War II. This unit offers high school students a unique introduction to France in the mid-1990s. The mini-unit includes a two-sided poster, teaching tips, and student pages. Student…

Looking for Work: The Coverage of Work in Canadian Introductory Sociology Textbooks

ERIC Educational Resources Information Center

Dixon, Shane Michael; Quirke, Linda

2014-01-01

This paper examines the textual coverage of the topic of work in Canadian English--language introductory sociology textbooks. Our findings are based on a content analysis of 21 Canadian texts published between 2008 and 2012. We found that only 12 of 21 textbooks included a chapter on work, suggesting that work occupies a peripheral position in…

Gunner Goggles: Implementing Augmented Reality into Medical Education.

PubMed

Wang, Leo L; Wu, Hao-Hua; Bilici, Nadir; Tenney-Soeiro, Rebecca

2016-01-01

There is evidence that both smartphone and tablet integration into medical education has been lacking. At the same time, there is a niche for augmented reality (AR) to improve this process through the enhancement of textbook learning. Gunner Goggles is an attempt to enhance textbook learning in shelf exam preparatory review with augmented reality. Here we describe our initial prototype and detail the process by which augmented reality was implemented into our textbook through Layar. We describe the unique functionalities of our textbook pages upon augmented reality implementation, which includes links, videos and 3D figures, and surveyed 24 third year medical students for their impression of the technology. Upon demonstrating an initial prototype textbook chapter, 100% (24/24) of students felt that augmented reality improved the quality of our textbook chapter as a learning tool. Of these students, 92% (22/24) agreed that their shelf exam review was inadequate and 19/24 (79%) felt that a completed Gunner Goggles product would have been a viable alternative to their shelf exam review. Thus, while students report interest in the integration of AR into medical education test prep, future investigation into how the use of AR can improve performance on exams is warranted.

How do the high school biology textbooks introduce the nature of science?

NASA Astrophysics Data System (ADS)

Lee, Young H.

2007-05-01

Although helping students to achieve an adequate understanding of the nature of science has been a consistent goal for science education for over half a century, current research reveals that the majority of students and teachers have naive views of the nature of science (Abd-El-khalick & Akerson, 2004; Bianchini & Colburn, 2000). This problem could be attributed not only to the complex nature of science, but also to the way the nature of science is presented to students during instruction. Thus, research must be conducted to examine how the science is taught, especially in science textbooks, which are a major instructional resource for teaching science. The aim of this study was to conduct a content analysis of the first chapter of four high school biology textbooks, which typically discusses "What is science?" and "What is biology?" This research used a content analysis technique to analyze the four high school biology textbooks, using a conceptual framework that has been used often for science textbook analysis. This conceptual framework consists of four themes of the nature of science: (a) science as a body of knowledge, (b) science as a way of thinking, (c) science as a way of investigating, and (d) the interaction of science, technology, and society. For this study, the four-theme-framework was modified to incorporate descriptors from national-level documents, such as Science for All Americans (AAAS, 1990) Benchmarks for Science Literacy (AAAS, 1993) and the National Science Education Standards (NRC, 1996), as well as science education research reports. A scoring procedure was used that resulted in good to excellent intercoder agreement with Cohen's kappa (k) ranging from .63 to .96. The findings show that the patterns of presentation of the four themes of the nature of science in the four high school biology textbooks are similar across the different locations of data, text, figures, and assessments. On the other hand, the pattern of presentation of the four themes is diverse by the publishing company. Some high school biology textbooks reflect a more reasonably balanced treatment of the four themes of the nature of science than other textbooks. The authors of most high school biology textbooks are attempting to convey an idea of biology and how scientific enterprise works by engaging students in investigations and revealing the thinking process of scientists. In addition to the quantitative analysis, a qualitative analysis was undertaken in an attempt to achieve a more comprehensive understanding of the nature of science in high school biology textbooks. A more experienced textbook analyst and nature of science researcher helped to confirm the conclusions by the investigator, who also examined the data sources from the introductory chapters of the biology textbooks. Examination of the first chapter of high school biology textbooks, using a qualitative analysis, reveals that each textbook describes the nature of science in a considerably different manner. While the approaches and emphases used to present scientific enterprise are remarkably different in each textbook, generally high school biology textbooks present several common topics, such as characteristics of life, scientific methods, biological issues, and tools used in science. Most of the high school biology textbooks present a narrow view of scientific methods as well as science, technology, and society. The qualitative/case study approach provided an insightful perspective of how science is presented to the user. Given the importance of textbooks on teaching and learning of science, it is recommended that teachers be informed of the findings of this study in order for them to understand how the first chapter presents the nature of science, which in turn may influence how they select biology textbooks and supplement this content Further, textbook publishers should also be informed of the results of the research in order to design future textbooks and materials to include a more authentic view of the nature of science.

The Media Reader.

ERIC Educational Resources Information Center

Valdes, Joan; Crow, Jeanne

An anthology of readings in the media correlates chapter-by-chapter to the authors' textbook, "The Media Works." Fifteen chapters cover the study of newspapers, magazines, comics, popular music, television, movies, and advertising. The authors included represent varied perspectives on the media. The selections were chosen with the help of a…

Textbooks of Doubt: Using Systemic Functional Analysis to Explore the Framing of Climate Change in Middle-School Science Textbooks

ERIC Educational Resources Information Center

Román, Diego; Busch, K. C.

2016-01-01

Middle school students are learning about climate change in large part through textbooks used in their classes. Therefore, it is crucial to understand how the language employed in these materials frames this topic. To this end, we used systemic functional analysis to study the language of the chapters related to climate change in four sixth grade…

Reading in the Social Studies Classroom.

ERIC Educational Resources Information Center

Bullock, Terry L.; Hesse, Karl D.

This publication examines reading instruction techniques that can be used by teachers to diagnose and remedy students' weaknesses in reading social studies materials. There are four chapters. Chapter one discusses issues, including trends related to reading in the social studies and problems presented by social studies textbooks. Chapters two and…

Engineering mechanics: statics and dynamics. [Textbook

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sandor, B.I.

1983-01-01

The purpose of this textbook is to provide engineering students with basic learning material about statics and dynamics which are fundamental engineering subjects. The chapters contain information on: an introduction to engineering mechanics; forces on particles, rigid bodies, and structures; kinetics of particles, particle systems, and rigid bodies in motion; kinematics; mechanical vibrations; and friction, work, moments of inertia, and potential energy. Each chapter contains introductory material, the development of the essential equations, worked-out example problems, homework problems, and, finally, summaries of the essential methods and equations, graphically illustrated where appropriate. (LCL)

Ostomy

MedlinePlus

... Chapter 31. Intestinal Stomas. Chapter in Beck, D.E., Roberts, P.L., Saclarides, T.J., Senagore, A.J., Stamos, M.J., Wexner, S.D., Eds. ASCRS Textbook of Colon and Rectal Surgery, 2nd Edition. Springer, New York, NY: 2011. National Digestive Disease Information ...

History of Binary and Other Nondecimal Numeration.

ERIC Educational Resources Information Center

Glaser, Anton

This study traces the development of nondecimal numeration from the 16th century to the present. The first six chapters detail the contributions of mathematicians as well as people from other fields. Applications to computers are covered in one chapter, while another chapter discusses the coverage of numeration systems in college textbooks for…

Reforming Educators: Teachers, Experts, and Advocates.

ERIC Educational Resources Information Center

Mitchell, Samuel

This textbook analyzes successful innovations in education. The first chapter provides an overview of the book, which is followed by a review of classical studies and disasters that have accompanied innovation. Chapter 3 offers a series of separate stories about the different ways teachers have responded to changes, and chapter 4 tries to reverse…

Similarity of Introductory Psychology Textbooks: Reality or Illusion?

ERIC Educational Resources Information Center

Griggs, Richard A.; Marek, Pam

2001-01-01

Presents a study that reviewed introductory psychology textbooks to examine the perception of extensive similarity. Focuses on six dimensions: (1) chapter topics, organization, and extent of topic coverage; (2) core concepts and key terms; (3) pedagogical aids and data graphs; (4) critical-thinking programs; (5) reference citations; and (6) level…

Emergency Victim Care. A Textbook for Emergency Medical Personnel.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Trade and Industrial Education Service.

This textbook for emergency medical personnel should be useful to fire departments, private ambulance companies, industrial emergency and rescue units, police departments, and nurses. The 30 illustrated chapters cover topics such as: (1) Emergency Medical Service Vehicles, (2) Safe Driving Practices, (3) Anatomy and Physiology, (4) Closed Chest…

Chapter & Verse

ERIC Educational Resources Information Center

Cavanagh, Sean

2006-01-01

Neal Frey reads textbooks for a living, a job he finds singularly fulfilling. For more than two decades, he had labored on behalf of Educational Research Analysts, a conservative Christian textbook-reviewing organization in Longview, Texas, founded by the famously outspoken husband-and-wife team of Mel Gabler and Norma Gabler. Since the early…

End of life content in geriatric textbooks: what is the current situation?

PubMed Central

Wu, Huei Yaw; Malik, Farida A; Higginson, Irene J

2006-01-01

Background Physicians caring for elderly people encounter death and dying more frequently than their colleagues in most other disciplines. Therefore we sought to examine the end-of-life content in popular geriatric textbooks and determine their usefulness in helping geriatricians manage patients at the end of their lives. Methods Five popular geriatric textbooks were chosen. Chapters on Alzheimer's disease, stroke, chronic heart failure, chronic obstructive pulmonary disease and lung cancer were examined because of their high mortality rates among the elderly patients. Text relevant to end-of-life care was highlighted. Two reviewers independently coded text into 10 pre specified domains and rated them for the presence of end-of-life information. Content was rated as absent, minimally helpful, or helpful. The proportion of helpful information was calculated. Results The textbook with the best end-of-life coverage contained 38% helpful information, the worst had only 15% helpful information. Minimally helpful information ranged from 24% to 50%. As much as 61% of the content in one textbook contained no helpful information at all. Of the ten domains, epidemiology, disease progression and prognostic factors were fairly well covered. Information on advance care planning, ethical issues, decision making and effects of death and dying on patient's family were generally lacking under the individual diseases though they were covered as general topics in other parts of the textbooks. All except one textbook dedicated a chapter to the care of the dying. Conclusion This study showed that end-of-life content in geriatric textbooks differed significantly. Most of the textbooks lack good coverage on end-of-life care and more can be done to improve on this. PMID:16737524

Fourier Analysis in Introductory Physics

NASA Astrophysics Data System (ADS)

Huggins, Elisha

2007-01-01

In an after-dinner talk at the fall 2005 meeting of the New England chapter of the AAPT, Professor Robert Arns drew an analogy between classical physics and Classic Coke. To generations of physics teachers and textbook writers, classical physics was the real thing. Modern physics, which in introductory textbooks "appears in one or more extra chapters at the end of the book, … is a divertimento that we might get to if time permits." Modern physics is more like vanilla or lime Coke, probably a fad, while "Classic Coke is part of your life; you do not have to think about it twice."

Think outside the Book

ERIC Educational Resources Information Center

Carney, Kevin

2011-01-01

Many students are capable of reading a chapter, doing the end-of-chapter questions, studying a little bit, and passing the chapter test. Many teachers are in the habit of using a textbook as a crutch to fall back on when creativity is lacking. Others are capable of teaching incredibly creative lessons based on state standards but are bound by the…

Earthquakes and Tsunamis. High School Teacher's Guidebook [and] High School Textbook.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France). Intergovernmental Oceanographic Commission.

This teacher's guide and student text detail the causes and effects of earthquakes and tsunamis. In the teacher's guidebook, suggested activities for each section of the text book's chapters as well as answers to the chapter test problems are presented. Worksheet masters are also provided. Chapters in both books are: (1) "Outside and Inside…

Comparative analysis of a nontraditional general chemistry textbook and selected traditional textbooks used in Texas community colleges

NASA Astrophysics Data System (ADS)

Salvato, Steven Walter

The purpose of this study was to analyze questions within the chapters of a nontraditional general chemistry textbook and the four general chemistry textbooks most widely used by Texas community colleges in order to determine if the questions require higher- or lower-order thinking according to Bloom's taxonomy. The study employed quantitative methods. Bloom's taxonomy (Bloom, Engelhart, Furst, Hill, & Krathwohl, 1956) was utilized as the main instrument in the study. Additional tools were used to help classify the questions into the proper category of the taxonomy (McBeath, 1992; Metfessel, Michael, & Kirsner, 1969). The top four general chemistry textbooks used in Texas community colleges and Chemistry: A Project of the American Chemical Society (Bell et al., 2005) were analyzed during the fall semester of 2010 in order to categorize the questions within the chapters into one of the six levels of Bloom's taxonomy. Two coders were used to assess reliability. The data were analyzed using descriptive and inferential methods. The descriptive method involved calculation of the frequencies and percentages of coded questions from the books as belonging to the six categories of the taxonomy. Questions were dichotomized into higher- and lower-order thinking questions. The inferential methods involved chi-square tests of association to determine if there were statistically significant differences among the four traditional college general chemistry textbooks in the proportions of higher- and lower-order questions and if there were statistically significant differences between the nontraditional chemistry textbook and the four traditional general chemistry textbooks. Findings indicated statistically significant differences among the four textbooks frequently used in Texas community colleges in the number of higher- and lower-level questions. Statistically significant differences were also found among the four textbooks and the nontraditional textbook. After the analysis of the data, conclusions were drawn, implications for practice were delineated, and recommendations for future research were given.

Fundamentals of Condensed Matter Physics Marvin L. Cohen and Steven G. Louie

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devanathan, Ram

This graduate level textbook on Condensed Matter Physics is written lucidly by two leading luminaries in this field. The volume draws its material from the graduate course in condensed matter physics that has been offered by the authors for several decades at the University of California, Berkeley. Cohen and Louie have done an admirable job of guiding the reader gradually from elementary concepts to advanced topics. The book is divided into four main parts that have four chapters each. Chapter 1 presents models of solids in terms of interacting atoms, which is appropriate for the ground state, and excitations tomore » describe collective effects. Chapter 2 deals with the properties of electrons in crystalline materials. The authors introduce the Born-Oppenheimer approximation and then proceed to the periodic potential approximation. Chapter 3 discusses energy bands in materials and covers concepts from the free electron model to the tight binding model and periodic boundary conditions. Chapter 4 starts with fixed atomic cores and introduces lattice vibrations, phonons, and the concept of density of states. By the end of this part, the student should have a basic understanding of electrons and phonons in materials. Part II presents electron dynamics and the response of materials to external probes. Chapter 5 covers the effective Hamiltonian approximation and the motion of the electron under a perturbation, such as an external field. The discussion moves to many-electron interactions and the exchange-correlation energy in Chapter 6, the widely-used Density Functional Theory (DFT) in chapter 7, and the dielectric response function in Chapter 8. The next two parts of the book cover advanced topics. Part III begins with a discussion of the response of materials to photons in Chapter 9. Chapter 10 goes into the details of electron-phonon interactions in different materials and introduces the polaron. Chapter 11 presents electron dynamics in a magnetic field and Chapter 12 discusses electrical and thermal transport in materials. Part IV takes the reader further into many body effects, superconductivity, and nanoscale materials. The authors introduce Feynman diagrams and many-body perturbation theory in Chapter 13, theories of superconductivity in Chapter 14, magnetism in Chapter 15, and low dimensional systems in Chapter 16. The first two parts are required reading for the beginner planning to perform DFT calculations. The advanced student interested in conducting research in condensed matter physics will benefit from continuing on to the last two parts. There is a set of problems at the end of each part. The narrative is aided by equations and detailed figures. References at the end of the book direct the reader to relevant books and review articles for each chapter. The inside covers include a periodic table and a useful list of fundamental physical constants. The authors present the underlying mathematics elegantly, which makes the textbook quite readable for those with a good mathematical background. Students lacking a firm footing in math will find the terrain rough after Chapter 1. This field has seen many good undergraduate textbooks including those by Kittel and by Ashcroft and Mermin. This volume fills the need for a rigorous graduate level textbook, and is a required addition to the bookshelf of every condensed matter physicist. Cohen and Louie have brought refreshing clarity to a challenging subject and made it eminently accessible to the motivated student.« less

Textbook of Child and Adolescent Psychiatry. 3rd Edition.

ERIC Educational Resources Information Center

Wiener, Jerry M.; Dulcan, Mina K.

The third edition of this textbook continues its tradition of integrating clinical wisdom and scientific research to improve patient care and advocacy for children and families. Each of the 56 chapters presents a summary of a core topic, blending clinical experience with evidence-based practices in assessment and treatment. Divided into 10 parts,…

Collective Design of an E-Textbook: Teachers' Collective Documentation

ERIC Educational Resources Information Center

Gueudet, Ghislaine; Pepin, Birgit; Sabra, Hussein; Trouche, Luc

2016-01-01

In this study, we investigated design processes in teacher collectives, which have been made possible by new "digital" opportunities: platforms, discussion lists, etc. The object of our study is the French Sésamath teacher association and its design of a grade 10 e-textbook, more precisely the design of the "functions" chapter.…

Behavior Management Strategies for Teachers. A Student Workbook. 2nd Edition.

ERIC Educational Resources Information Center

Harlan, Joan C.; Rowland, Sidney T.

This student workbook is designed to accompany the textbook, "Behavior Management Strategies for Teachers," helping to reinforce understanding of the basic principles described in the companion textbook. It presents a summary of the key concepts in each of the workbook's 15 chapters. Questions in this student workbook are based on each…

Fourier Analysis in Introductory Physics

ERIC Educational Resources Information Center

Huggins, Elisha

2007-01-01

In an after-dinner talk at the fall 2005 meeting of the New England chapter of the AAPT, Professor Robert Arns drew an analogy between classical physics and Classic Coke. To generations of physics teachers and textbook writers, classical physics was the real thing. Modern physics, which in introductory textbooks "appears in one or more extra…

Ciencias 2. Manual do Professor (Science Teacher's Manual).

ERIC Educational Resources Information Center

Raposo, Lucilia

This is the teacher's manual for Ciencias 2, the second in a series of elementary science textbooks for Portuguese-speaking students. The student textbook contains 10 chapters and 57 activities. The teacher's manual presents an explanation of the educational goals and the organization of the content, Topics included are environment, the human,…

Technical Mathematics: Restructure of Technical Mathematics.

ERIC Educational Resources Information Center

Flannery, Carol A.

Designed to accompany a series of videotapes, this textbook provides information, examples, problems, and solutions relating to mathematics and its applications in technical fields. Chapter I deals with basic arithmetic, providing information on fractions, decimals, ratios, proportions, percentages, and order of operations. Chapter II focuses on…

Principles of School Business Management.

ERIC Educational Resources Information Center

Wood, R. Craig, Ed.

This textbook of 24 chapters provides administrators and students with information on the role, activities, and responsibilities of the school business administrator. The independently authored chapters are titled as follows: (1) "Introduction to School Business Management" (F. Mike Miles); (2) "Legal Context of the Public School District" (Paul…

Machinery Repairman 3 & 2. Rate Training Manual and Nonresident Career Course. Revised.

ERIC Educational Resources Information Center

Bynum, Michael H.; Taylor, Edward A.

This Rate Training Manual (textbook) and Nonresident Career Course form a correspondence self-study package to teach the theoretical knowledge and mental skills needed by the Machinery Repairman Third Class and Second Class. The 15 chapters in the textbook are (1) Scope of the Machinery Repairman Rating; (2) Toolrooms and Tools; (3) Layout and…

Knowledge transfer: a worldwide challenge in child mental health: a recommendation to the readership of CAPMH concerning the revised version of the IACAPAP Textbook of Child and Adolescent Mental Health.

PubMed

Maier, Anna T; Brown, Rebecca C; Fegert, Joerg M

2018-01-01

Transfer of knowledge is an important issue throughout all scientific disciplines, especially in the medical and psycho-social field. The issue of worldwide knowledge transfer in child mental health is one of the aims and goals of the journal Child and Adolescent Psychiatry and Mental Health (CAPMH). The demand for mental health training is high worldwide, and especially in low- to lower-middle income countries, where inadequate access to knowledge resources in the field of child and adolescent mental health (CAMH) is prevalent. At the same time, many of these countries are showing an increased risk for mental health issues in children and adolescents. The International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) Textbook of Child and Adolescent Mental Health counters this problem. It is an open-access e-textbook aiming to provide an overview of current and established treatment and practical approaches for child and adolescent psychiatrists, psychotherapists and allied (mental health) professionals worldwide. First published in 2012, the updated and revised version was launched in 2015. The aim of this commentary is to review and disseminate the usefulness and practicability of content and further material included in the new version of the textbook. Overall, the textbook contains ten sections divided into 59 chapters, with a total of 1435 pages. The original version of the textbook was written in English. The revised version contains translations of 49 chapters into different languages (to date French, Spanish, Hebrew, Arabic, Portuguese, Russian, Norwegian and/or Japanese), with additional material for knowledge dissemination and self-directed learning (e.g. videos and quizzes) for several chapters. The textbook and the add-on materials for dissemination are of high quality and convey a great introduction to important topics concerning mental health. Apart from knowledge transfer, there is a pragmatic focus on clinical practice and on regional and cultural differences. The textbook is a new and unique opportunity for professionals all over the world to improve their knowledge, skills and expertise in CAMH. High-quality, up-to-date and freely accessible materials in the field of CAMH are combined with the opportunity to share insights with colleagues.

CyberEconomics.

ERIC Educational Resources Information Center

Schenk, Robert

2003-01-01

Describes CyberEconomics, a complete, free, two-semester principles of economics textbook available on the World Wide Web. Contains chapters, sections, a table of contents, a set of learning objectives, and links to chapter introductions and sections. Offers a CD-ROM version available for a fee that contains interactive review questions. (JEH)

Genetic data analysis for plant and animal breeding

USDA-ARS?s Scientific Manuscript database

This book is an advanced textbook covering the application of quantitative genetics theory to analysis of actual data (both trait and DNA marker information) for breeding populations of crops, trees, and animals. Chapter 1 is an introduction to basic software used for trait data analysis. Chapter 2 ...

Electricity: Today's Technologies, Tomorrow's Alternatives. Teacher's Guide.

ERIC Educational Resources Information Center

Electric Power Research Inst., Palo Alto, CA.

This teaching guide is designed to help teachers develop lesson plans around nine chapters provided in the student textbook. Chapters focus on energy use, energy demand, energy supply, principles of electric power generation, today's generating options, future generating options, electricity storage and delivery, environmental concerns, and making…

Applying Theory to the Case Study Course.

ERIC Educational Resources Information Center

Kruckeberg, Dean

A chronic problem in public relations education is the fragmentation of coursework, particularly as this fragmentation impacts on the application of communication theory. Public relations textbooks presentation of theory is often fragmented and segregated in to "theoretical" chapters and "applied" chapters with little integration between the two.…

Sport & Fitness Management: Career Strategies and Professional Content.

ERIC Educational Resources Information Center

Parks, Janet B., Ed.; Zanger, Beverly R. K., Ed.

This textbook provides a comprehensive introduction to the field of sport management. An introductory chapter gives the definition and direction of sport and fitness management. Part 1 describes sport and fitness management careers. The 12 chapters deal with the professional options: intercollegiate athletics, professional sport, facility…

Investigating the Conceptual Variation of Major Physics Textbooks

NASA Astrophysics Data System (ADS)

Stewart, John; Campbell, Richard; Clanton, Jessica

2008-04-01

The conceptual problem content of the electricity and magnetism chapters of seven major physics textbooks was investigated. The textbooks presented a total of 1600 conceptual electricity and magnetism problems. The solution to each problem was decomposed into its fundamental reasoning steps. These fundamental steps are, then, used to quantify the distribution of conceptual content among the set of topics common to the texts. The variation of the distribution of conceptual coverage within each text is studied. The variation between the major groupings of the textbooks (conceptual, algebra-based, and calculus-based) is also studied. A measure of the conceptual complexity of the problems in each text is presented.

Replicating a survey of pressure ulcer content in nursing textbooks.

PubMed

Ayello, Elizabeth A; Meaney, Geraldine

2003-09-01

Nurses enter the profession with knowledge about pressure ulcer prevention and care and acquired from their basic educational programs. A prior review of nursing textbooks regarding pressure ulcer content published almost a decade ago revealed that incomplete, inaccurate, and at times limited information (as few as 200 lines of text) was contained in 10 commonly used textbooks. A review of the updated editions of the textbooks revealed a wide variation in the number of lines of text devoted to pressure ulcers, depth and quality of information, and the number of illustrations and tables. New findings were the inclusion of cultural concepts and research studies. These findings suggest an improvement in the amount and quality of pressure ulcer information in the majority of nursing textbooks surveyed. Recommendations for future textbook chapters on pressure ulcers are provided.

Calculus of Elementary Functions, Part IV. Teacher's Commentary. Preliminary Edition.

ERIC Educational Resources Information Center

Herriot, Sarah T.; And Others

This teacher's guide is designed for use with the SMSG textbook "Calculus of Elementary Functions." It contains solutions to exercises found in Chapter 9, Integration Theory and Technique; Chapter 10, Simple Differential Equations; Appendix 5, Area and Integral; Appendix 6; Appendix 7, Continuity Theory; and Appendix 8, More About…

Theory of Aircraft Flight. Aerospace Education II.

ERIC Educational Resources Information Center

Glascoff, W. G., III

The textbook provides answers to many questions related to airplanes and properties of air flight. The first chapter provides a description of aerodynamic forces and deals with concepts such as acceleration, velocity, and forces of flight. The second chapter is devoted to the discussion of properties of the atmosphere. How different…

Developing Teaching Skills in Physical Education.

ERIC Educational Resources Information Center

Siedentop, Daryl

This textbook attempts to clarify the nature of teaching during the field experience or simulation of that experience for student teachers. The text takes a data-based approach to the development of teaching skills. It is divided into seven chapters. The first chapter, "Systematic Improvement of Teaching Skills," is a narrative…

SKILL DEVELOPMENT THROUGH GAMES AND RHYTHMIC ACTIVITIES.

ERIC Educational Resources Information Center

NAGEL, CHARLES; MOORE, FREDRICKA

A DISCUSSION OF THE OVERALL OBJECTIVES OF PHYSICAL ACTIVITIES IN THE ELEMENTARY SCHOOL, THE PURPOSES OF DEVELOPING MOVEMENT SKILLS IN GAMES AND RHYTHMS, AND THE ROLE OF THE TEACHER IN PHYSICAL EDUCATION COMPRISES THE INTRODUCTORY CHAPTER OF THIS TEXTBOOK FOR BEGINNING PHYSICAL EDUCATION TEACHERS. SUCCEEDING CHAPTERS ARE CONCERNED WITH FIVE…

Unified Technical Concepts. Physics for Technicians.

ERIC Educational Resources Information Center

Center for Occupational Research and Development, Inc., Waco, TX.

Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary programs. This UTC classroom textbook, consisting of 14 chapters, deals with physics for technicians. Addressed in the individual chapters of the guide are the following topics: force, work, rate, momentum, resistance, power, potential and…

Air Conditioning, Heating, and Refrigeration. Competency-Based Curriculum Manual.

ERIC Educational Resources Information Center

Gourley, Frank A., Jr.

This manual was developed to serve as an aid to administrators and instructors involved with postsecondary air conditioning, heating, and refrigeration programs. The first of six chapters contains general information on program implementation, the curriculum design, facilities and equipment requirements, and textbooks and references. Chapter 2…

Teaching About the Creation/Evolution Controversy. Fastback 134.

ERIC Educational Resources Information Center

Bergman, Jerry

The booklet discusses questions related to teaching engendered by the creation/evolution controversy, presents current positions of educators and textbooks, and recommends a two-model teaching approach. It is divided into six chapters. Chapter I defines and summarizes evolution and creationism as different belief structures, and outlines various…

Unified Technical Concepts. Math for Technicians.

ERIC Educational Resources Information Center

Center for Occupational Research and Development, Inc., Waco, TX.

Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC classroom textbook, consisting of 10 chapters, deals with mathematical concepts as they apply to the study of physics. Addressed in the individual chapters of the text are the following topics: angles and…

Bringing out the "Main Characters" in General Chemistry: Can Creating a Sense of Narrative in the Classroom and for the Textbook Aid Long-Term Memory?

ERIC Educational Resources Information Center

Chang, Junyoung; Churchill, David

2011-01-01

A new approach for teaching general chemistry is presented and discussed. Importantly, a storyline approach is provided in which the same chemical item or concept is reintroduced and embellished from chapter to chapter. The intention is to bring more connectivity between the various seemingly unrelated chapters. This might lead to a more…

A Preliminary Bloom's Taxonomy Assessment of End-of-Chapter Problems in Business School Textbooks

ERIC Educational Resources Information Center

Marshall, Jennings B.; Carson, Charles M.

2008-01-01

This article examines textbook problems used in a sampling of some of the most common core courses found in schools of business to ascertain what level of learning, as defined by Bloom's Taxonomy, is required to provide a correct answer. A set of working definitions based on Bloom's Taxonomy (Bloom & Krathwohl, 1956) was developed for the six…

Political Partisanship, Bureaucratic Pragmatism and Acadian Nationalism: New Brunswick, Canada's 1920 History Textbook Controversy

ERIC Educational Resources Information Center

Helyar, Frances

2014-01-01

During a time of post-war sensitivity to Canadian nationalism and patriotism, public feeling was aroused in 1920 New Brunswick regarding a world history textbook with a new chapter about the First World War. The American author made no reference to Canada's war efforts. The subsequent public discussion focused on issues of patriotism, citizenship,…

Financial Investigations. A Financial Approach to Detecting and Resolving Crimes. [Text], Instructor's Guide, and Student Workbook.

ERIC Educational Resources Information Center

Internal Revenue Service (Dept. of Treasury), Washington, DC.

This packet contains a textbook, an instructor's guide, and a student workbook for a course on conducting financial investigations to detect and solve crimes. The topics covered in the 11 chapters of the textbook and the ancillaries are the following: (1) why financial investigation?; (2) laws related to financial crimes; (3) evidence; (4) sources…

Emotional Intelligence and Its Link to Public Relations Education

ERIC Educational Resources Information Center

Howard, Timothy Lent

2011-01-01

The purpose of this study is to examine the ethics chapters in five introduction-to-public relations textbooks and the codes of ethics of four major public relations associations contained within those chapters to determine the prevalence of language that either uses the same terms Daniel Goleman employs for his 25 competencies of emotional…

PRESERVING DRINKING WATER INTEGRITY IN OUR COMMUNITIES: HOMELAND SECURITY PRIORITIES OF THE ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

A book chapter published in a 3-volume textbook series by the U. S. Military Academy at West Point, Combating Terrorism Center. Book title: Homeland Security: Protecting America's Targets. The chapter is a review of background of water systems, impact of September 11, 2001, a...

Theory of Aircraft Flight. Aerospace Education II.

ERIC Educational Resources Information Center

Elmer, James D.

This revised textbook, one in the Aerospace Education II series, provides answers to many questions related to airplanes and properties of air flight. The first chapter provides a description of aerodynamic forces and deals with concepts such as acceleration, velocity, and forces of flight. The second chapter is devoted to the discussion of…

Content Analysis of Students' Favorite Magazines: Class Exercise

ERIC Educational Resources Information Center

Glaser, Hollis F.

2011-01-01

Corporate influence is a defining characteristic of mass media in the U.S. A typical introductory textbook devotes a number of chapters to the economic structure of the mass media including advertising, public relations, and corporate ownership, then also includes chapter sections on the economics of the various media (television, radio,…

Psychology Teacher's Resource Book. First Course, Third Edition.

ERIC Educational Resources Information Center

Johnson, Margo, Ed.; Wertheimer, Michael, Ed.

Now in its third edition, this book contains background materials and resources for teaching introductory high school psychology. There are 11 chapters. Textbooks appropriate for introductory courses are reviewed in the first chapter. Books of reading which are a potentially valuable source of information to both student and teacher are listed in…

Secondary School Mathematics Special Edition, Chapter 12. Similarity, Chapter 13. More About Rational Numbers, Chapter 14. Perpendiculars, Student's Text.

ERIC Educational Resources Information Center

DeVenney, William S.; And Others

This text is one of the sequence of textbooks produced for low achievers in the seventh and eighth grades by the School Mathematics Study Group (SMSG). There are eight texts in the sequence, of which this is the sixth. This set of volumes differs from the regular editions of SMSG junior high school texts in that very little reading is required.…

The Importance and Interest of Introductory Psychology Textbook Topics: Student Opinions at Technical College, 2-, and 4-Year Institutions

ERIC Educational Resources Information Center

McCann, Lee I.; Immel, Kathy R.; Kadah-Ammeter, Tammy L.; Adelson, Sarah K.

2016-01-01

Introductory psychology students at a technical college, 2-year community college, and a regional university rated how important textbook chapters or topics were to them now and in the future and how interesting they were. Importance and interest ratings were highly correlated, and the whole course was rated of greater importance and interest than…

BOOK REVIEW: Solid State Physics: An Introduction

NASA Astrophysics Data System (ADS)

Jakoby, Bernhard

2009-07-01

There's a wealth of excellent textbooks on solid state physics. The author of the present book is well aware of this fact and does not attempt to write just another one. Rather, he has provided a very compact introduction to solid state physics for third-year students. As we are faced with the continuous appearance interdisciplinary fields and associated study curricula in natural and engineering sciences (biophysics, mechatronics, etc), a compact text in solid state physics would be appreciated by students of these disciplines as well. The book features 11 chapters where each is provided with supplementary discussion questions and problems. The first chapters deal with a review of chemical bonding mechanisms, crystal structures and mechanical properties of solids, which are brief but by no means superficial. The following, somewhat more detailed chapter on thermal properties of lattices includes a nice introduction to phonons. The foundations of solid state electronics are treated in the next three chapters. Here the author first discusses the classical treatment of electronic behaviour in metals (Drude model) and continues with a quantum-theoretical approach starting with the free-electron model and leading to the band structures in conductive solids. The next chapter is devoted to semiconductors and ends with a brief but, with respect to the topical scope, adequate discussion of semiconductor devices. The classical topics of magnetic and dielectric behaviour are treated in the sequel. The book closes with a chapter on superconductivity and a brief chapter covering the modern topics of quantum confinement and aspects of nanoscale physics. In my opinion, the author has succeeded in creating a very concise yet not superficial textbook. The account presented often probes subjects deep enough to lay the basis for a thorough understanding, preparing the reader for more specialized textbooks. For instance, I think that this book may serve as an excellent first introduction to semiconductor physics. Of course, the detailed treatment of some topics had to be spared and it is certainly a matter of taste which subjects should be treated in detail in a solid state textbook and which can be covered by references to other textbooks or further literature. A typical example for the latter is the decision to omit the detailed treatment of the local field concept leading to the Clausius-Mosotti relation. What could be improved in further editions (which will hopefully be coming) are more specific cross-references within the book and to other textbooks. In the current edition, missing internal cross-references can be compensated for by consulting the subject index, but it would be nicer to have these in the text. As mentioned above, I expect that this book will also be useful to engineering students. For these, it would be beneficial to provide more details on underlying terms and concepts that they, according to common engineering curricula, may not be that familiar with. Examples for such topics are quantum theory beyond the very first principles (e.g., multi-particle treatment, operators and observables) and thermodynamics (e.g., the relevance of electrochemical potential and Fermi levels). These topics could be treated in a concise manner in additional appendices. The current appendix is very short and rudimentary at times, e.g., for the microscopic form of Maxwell's equations, electric and magnetic fluxes are introduced but not outlined further (in that respect, it could also be useful to have a list of used symbols). In summary, this textbook definitely has an interesting scope within an established field and it has been written with appealing didactic skills. This first edition truly deserves to be discovered by students of various disciplines, who want to obtain a quick introduction to solid state physics.

The Consumer and His Dollars: A Workbook and Study Guide.

ERIC Educational Resources Information Center

Finegan, Marcella E.

This workbook and study guide for a money management curriculum in consumer education was written to accompany the textbook "The Consumer and His Dollars" and a teacher's guide, both announced in this issue as VT 017 179 and VT 017 177. Included are 16 chapters, each containing worksheets perforated for easy removal. Chapter highlights,…

Teaching Special Relativity without Calculus

ERIC Educational Resources Information Center

Ruby, Lawrence

2009-01-01

In 2007 many AAPT members received a booklet that is the first chapter of a physics textbook available on a CD. This book espouses the new educational philosophy of teaching special relativity as the first item in the topic of mechanics. Traditionally, special relativity is part of one or more modern physics chapters at the end of the text, and…

A content analysis of sixth-grade, seventh-grade, and eighth-grade science textbooks with regard to the nature of science

NASA Astrophysics Data System (ADS)

Phillips, Marianne C.

Science teachers rely heavily on their textbooks; for many, it is the only curriculum they use (Weiss, 1993). Therefore, it is important these materials convey an accurate conception of the nature of science. Science for All Americans (AAAS, 1990) and the National Science Education Standards (NRC, 1996) call for teaching students about the nature of science. Including the nature of science throughout science textbooks will produce scientifically literate citizens (Driver and others, 1993) with an improved ability to make informed decisions (McComas, 1998). Teaching the nature of science supports the successful learning of science content and process (Driver and others, 1996), and bridges the gap between the two cultures of practicing scientists and school science (Sorsby, 2000). Do middle school science textbooks provide a balanced presentation of the nature of science throughout their text? To determine the answer, this investigation used a content analysis technique to analyze a random sample from the introduction chapter and the rest of the textbook chapters from twelve middle school science textbooks for the four aspects of the nature of science (Chiappetta, Fillman, & Sethna, 2004). Scoring procedures were used to determine interrater agreement using both Cohen's kappa (kappa) and Krippendorff's alpha (alpha). Kappa values were determined to be fair to excellent beyond chance among the three coders. The resulting values for Krippendorff's alpha ranged from acceptable (alpha > .80) to unacceptable (alpha < .67). The results from this content analysis indicated little change from previous studies in the balance for the themes of the nature of science. This investigation found the sixth-grade, seventh-grade, and eighth-grade science textbooks adopted by Texas to have unbalanced presentations for the four aspects of the nature of science. In addition, it found these middle school science textbooks are not balanced across programs. This imbalance is providing students with a rudimentary and fragmented view of how science works, despite the fact that science impacts every aspect of life (McComas, 1998). Given the impact of textbooks on learning, it is recommended that teachers be informed of these shortcomings to enable them to supplement content where it is lacking.

Genesis of a bad idea

NASA Astrophysics Data System (ADS)

Carlowicz, Michael

According to an article in Business Week (June 10), Macmillan/McGraw-Hill Inc. has agreed to custom-publish a version of its fourth-grade textbook Changing Earth in order to omit a chapter entitled “Birth of Earth.” Parents in the Cobb County, Georgia, school district complained that since the chapter does not include creationism as a theory for the origin of the universe and of Earth, the entire discussion ought to be left out.According to McGraw-Hill, customizing its textbooks is good business. Changing Earth and other such books are designed to allow teachers to build their own programs; the company is willing to customize texts because it does not want to dictate curricula, and it tries to meet demands of school districts. Business Week noted that the theory of evolution still is taught in the sixth and eighth grades, as well as high school, in Cobb County. Changing Earth also contains references to evolution in other chapters besides the one being deleted.

Indexing of Iranian Publications in Well-known Endodontic Textbooks: A Scientometric Analysis.

PubMed

Kakooei, Sina; Mostafavi, Mahshid; Parirokh, Masoud; Asgary, Saeed

2016-01-01

Quoting an article in well-known textbooks is held as a credit for that paper. The numbers of Iranian publications mentioned in endodontic textbooks have increased during recent years. The aim of this investigation was to evaluate the number of Iranian articles quoted in eminent endodontic textbooks. Three known textbooks (Ingle's Endodontics, Seltzer and Bender's Dental Pulp and Cohen's Pathways of the Pulp) were chosen and all the editions of the textbooks since 2000 were investigated for quoted Iranian publications. Only Iranian authors with affiliations from a domestic university were chosen. All references at the end of each chapter were read by hand searching, and results were noted. The trend and percentage of Iranian publications in different editions of the textbooks were also calculated. The number of citations of these publications in Google Scholar and Scopus databases were also obtained. The number of Iranian publications in all well-known textbooks have notably increased since 2000. The number and percentage of Iranian publications in the latest edition of Cohen's Pathways of the Pulp was higher compared to other textbooks as well as the previous edition of the same text. Number and percentage of Iranian publications in the field of endodontics in all three textbooks have remarkably increased since 2000.

How Discourses of Biology Textbooks Work to Constitute Subjectivity: From the Ethical to the Colonial

NASA Astrophysics Data System (ADS)

Bazzul, Jesse

This thesis examines how discourses of biology textbooks can work to constitute various kinds of subjectivities. Using a Foucauldian archaeological approach to discourse analysis I examine how four Ontario secondary school biology textbooks discursively delimit what can be thought and acted upon, and in the process work to partially constitute students/teachers as sex/gendered; neocolonial; neoliberal (and a subject of work), and ethical subjects and subjectivities. This thesis engages the topic of how discourse can constitute subjectivity in science in three basic ways: First, on a theoretical level, in terms of working out an understanding of subject constitution/interpellation that would also be useful when engaging with other sociopolitical and ethical questions in science education. Secondly, in terms of an empirically based critical discourse analysis that examines how various statements within these four textbooks could set limits on what is possible for students to think and act upon in relation to themselves, science, and the world. Thirdly, this thesis represents a narrative of scholarly development that moves from an engagement of my personal experiences in science education and current science education literature towards the general politico-philosophical topic of subjectivity and biopolitics. This thesis begins with a discussion of my experiences as a science teacher, a review of relevant science education literature, and considerations of subjectivity that relate specifically ii to the specific methodological approach I employ when examining these textbooks. After this I present five chapters, each of which can be thought of as a somewhat separate analysis concerning how the discourses of these textbooks can work to constitute specific subjectivities (each involving different theoretical/methodological considerations). I conclude with a reflection/synthesis chapter and a call to see science education as a site for biopolitical struggle.

BOOK REVIEW: Introductory Nanoscience: Physical and Chemical Concepts Introductory Nanoscience: Physical and Chemical Concepts

NASA Astrophysics Data System (ADS)

Bich Ha, Nguyen

2011-12-01

Having grown rapidly during the last two decades, and successfully synthesized the achievements of physics, chemistry, life science as well as information and computational science and technology, nanoscience and nanotechnology have emerged as interdisciplinary fields of modern science and technology with various prospective applications towards environmental protection and the sustainable development of industry, agriculture, public health etc. At the present time, there exist many textbooks, monographs and encyclopedias on nanoscience and nanotechnology. They present to readers the whole process of development from the emergence of new scientific ideas to comprehensive studies of concrete subjects. They are useful for experienced scientists in nanoscience and nanotechnology as well as related scientific disciplines. However, there are very few textbooks on nanoscience and nanotechnology for beginners—senior undergraduate and junior graduate students. Published by Garland Science in August 2011, Introductory Nanoscience: Physical and Chemical Concepts by Masaru Kuno is one of these rare textbooks. The purpose of this book is twofold. In a pedagogical manner the author presents the basic physical and chemical concepts of nanoscience and nanotechnology. Students with a background knowledge in general chemistry and semiclassical quantum physics can easily understand these concepts. On the other hand, by carefully studying the content of this textbook, readers can learn how to derive a large number of formulae and expressions which they will often use in their study as well as in their future research work. A distinguishing feature of the book is the inclusion of a large number of thought problems at the end of each chapter for demonstrating how to calculate the numerical values of almost all physical quantities involved in the theoretical and experimental studies of all subjects of nanoscience and nanotechnology. The author has successfully achieved both of the main aims of the textbook. The book consists of 15 chapters. According to their detailed contents they can be divided into three groups. In five chapters forming the first group (Introduction, Structure, Length Scales, Types of Nanostructures, Absorption and Emission Basics) the author presents the notions, definitions and concepts related to nanosystems, as well as the length scales of all their physical parameters. The contents of these chapters have been written for all readers studying any undergraduate academic programme in natural sciences and engineering. The subsequent seven chapters forming the second group (A Quantum Mechanics Review, Model Quantum Mechanics Problems, Additional Model Problems, Density of States, Bands, Time-Dependent Perturbation Theory, Interband Transitions) contain a comprehensive and easily understandable presentation of the theoretical basics of nanoscience. The last three chapters (Synthesis, Characterization, Applications) contain presentations on the fundamental methods in the experimental studies and applications of nanosystems. This book is very useful not only for training beginners in research and engineering in nanoscience and nanotechnology, but also for attracting the interest of specialists in other scientific disciplines to the application of the achievements of this new emerging multidisciplinary scientific field.

Small Business Planning and Management for the First-Time Entrepreneur. Instructor's Resource Manual. Student Workbook.

ERIC Educational Resources Information Center

Hamilton, William H.; Connelly, Donald F.

This instructor's resource manual and student workbook accompany the textbook of the same name. The manual is intended to help the teacher working with the small business manager and first-time entrepreneur. Each chapter contains these sections: instructional goals; resource people; tips for follow-up activities at the end of each chapter;…

Hispanics in U.S. History. Volume 1: Through 1865. Volume 2: 1865 to the Present. The Newcomers Series.

ERIC Educational Resources Information Center

de Varona, Frank; And Others

Each of these two textbooks on Hispanic-American history contains 4 units divided into 20 chapters. Each chapter includes an overarching question; text; reading comprehension questions; study tips; an activity involving geography skills, links between past and present, or daily life; an activity involving arts and technology or using primary…

Turning Points in Qualitative Research: Tying Knots in a Handkerchief. Crossroads in Qualitative Inquiry Series.

ERIC Educational Resources Information Center

Lincoln, Yvonna S., Ed.; Denzin, Norman K., Ed.

The chapters of this volume traces the changes in the discipline of qualitative inquiry over the last five decades. The collection serves as a textbook for training scholars in the history and trajectory of qualitative research. The chapters of part 1, The Revolution of Representation: Feminist and Race/Ethnic Studies Discourses, are: (1) Situated…

Telling the Story of the American Presidency: Examining the Content and Perspective of Presidency Chapters in Introductory American Politics Texts

ERIC Educational Resources Information Center

Evans, Jocelyn Jones; Lindrum, David

2013-01-01

While previous scholarship suggests that "American government textbooks are more alike than they are different," an examination of the market's most frequently adopted texts suggests that this consistency does not extend much further than the subjects of major chapters. We explore the degree to which four major introductory American…

Book Review

NASA Astrophysics Data System (ADS)

Clevers, J. G. P. W.

2015-02-01

About thirty years after the previous advanced textbook on Microwave Remote Sensing by Ulaby, Moore and Fung has been published as three separate volumes, now an up-to-date new textbook has been published. The 1000-page book covers theoretical models, system design and operation, and geoscientific applications of active and passive microwave remote sensing systems. It is designed as a textbook at the postgraduate level, as well as a reference for the practicing professional. The book is caught by a thorough introduction into the physics and mathematics of electrical engineering applied to microwave radiation. Here on overview of its chapters with a short description of its focus will be given.

Crystal structure of the Csm3-Csm4 subcomplex in the type III-A CRISPR-Cas interference complex.

PubMed

Numata, Tomoyuki; Inanaga, Hideko; Sato, Chikara; Osawa, Takuo

2015-01-30

Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. Here, we show that the Csm1, Csm3, and Csm4 proteins from Methanocaldococcus jannaschii form a stable subcomplex. We also report the crystal structure of the M. jannaschii Csm3-Csm4 subcomplex at 3.1Å resolution. The complex structure revealed the presence of a basic concave surface around their interface, suggesting the RNA and/or DNA binding ability of the complex. A gel retardation analysis showed that the Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Based on bioinformatics, we constructed a model structure of the Csm1-Csm4-Csm3 ternary complex, which provides insights into its role in the Csm interference complex. Copyright © 2014 Elsevier Ltd. All rights reserved.

Women in American History: A Series. Book Four, Women in the Progressive Era 1890-1920.

ERIC Educational Resources Information Center

Sanders, Beverly

The document, one in a series of four on women in American history, discusses the role of women in the Progressive Era (1890-1920). Designed to supplement high school U.S. history textbooks, the book is comprised of five chapters. Chapter I describes reformers and radicals including Jane Addams and Lillian Wald who began the settlement house…

An Assessment of the Level of Mathematics in Introductory Meteorology Textbooks.

NASA Astrophysics Data System (ADS)

Ulanski, Stan L.

1992-10-01

A review of introductory meteorology textbooks shows a wide difference in the level of mathematical treatment of atmospheric principles-from virtually none to fairly high. Particular deficiencies include lack of equations integrated into the text, problem-solving examples, and paucity of end-of-chapter questions requiring mathematical reasoning. These issues are raised in order to generate discussion among the meteorological community with regard to the degree of interaction between mathematics and meteorology in introductory courses.

Representations of race and skin tone in medical textbook imagery.

PubMed

Louie, Patricia; Wilkes, Rima

2018-04-01

Although a large literature has documented racial inequities in health care delivery, there continues to be debate about the potential sources of these inequities. Preliminary research suggests that racial inequities are embedded in the curricular edification of physicians and patients. We investigate this hypothesis by considering whether the race and skin tone depicted in images in textbooks assigned at top medical schools reflects the diversity of the U.S. We analyzed 4146 images from Atlas of Human Anatomy, Bates' Guide to Physical Examination & History Taking, Clinically Oriented Anatomy, and Gray's Anatomy for Students by coding race (White, Black, and Person of Color) and skin tone (light, medium, and dark) at the textbook, chapter, and topic level. While the textbooks approximate the racial distribution of the U.S. population - 62.5% White, 20.4% Black, and 17.0% Person of Color - the skin tones represented - 74.5% light, 21% medium, and 4.5% dark - overrepresent light skin tone and underrepresent dark skin tone. There is also an absence of skin tone diversity at the chapter and topic level. Even though medical texts often have overall proportional racial representation this is not the case for skin tone. Furthermore, racial minorities are still often absent at the topic level. These omissions may provide one route through which bias enters medical treatment. Copyright © 2018. Published by Elsevier Ltd.

An analysis of how electromagnetic induction and Faraday's law are presented in general physics textbooks, focusing on learning difficulties

NASA Astrophysics Data System (ADS)

Guisasola, Jenaro; Zuza, Kristina; Almudi, José-Manuel

2013-07-01

Textbooks are a very important tool in the teaching-learning process and influence important aspects of the process. This paper presents an analysis of the chapter on electromagnetic induction and Faraday's law in 19 textbooks on general physics for first-year university courses for scientists and engineers. This analysis was based on criteria formulated from the theoretical framework of electromagnetic induction in classical physics and students' learning difficulties concerning these concepts. The aim of the work presented here is not to compare a textbook against the ideal book, but rather to try and find a series of explanations, examples, questions, etc that provide evidence on how the topic is presented in relation to the criteria above. It concludes that despite many aspects being covered properly, there are others that deserve greater attention.

Replacing textbook problems with lab experiences

NASA Astrophysics Data System (ADS)

Register, Trevor

2017-10-01

End-of-the-chapter textbook problems are often the bread and butter of any traditional physics classroom. However, research strongly suggests that students be given the opportunity to apply their knowledge in multiple contexts as well as be provided with opportunities to do the process of science through laboratory experiences. Little correlation has been shown linking the number of textbook problems solved with conceptual understanding of topics in mechanics. Furthermore, textbook problems as the primary source of practice for students robs them of the joy and productive struggle of learning how to think like an experimental physicist. Methods such as Modeling Instruction tackle this problem head-on by starting each instructional unit with an inquiry-based lab aimed at establishing the important concepts and equations for the unit, and this article will discuss ideas and experiences for how to carry that philosophy throughout a unit.

Women in American History: A Series. Book Two, Women in the Ages of Expansion and Reform 1820-1860.

ERIC Educational Resources Information Center

Sanders, Beverly

The document, one in a series of four on women in American history, discusses women in the ages of expansion and reform (1820-1860). Designed to supplement U.S. history textbooks, the book is presented in six chapters. Chapter I describes the "true woman," an ideal cultivated by women writers, educators, and magazine editors. The four virtues were…

Women in American History: A Series. Book Three, Women during and after the Civil War 1860-1890.

ERIC Educational Resources Information Center

Sanders, Beverly

The document, one in a series of four on women in American history, discusses the role of women during and after the Civil War (1860-1890). Designed to supplement high school U.S. history textbooks, the book is comprised of five chapters. Chapter I describes the work of Union and Confederate women ln the Civil War. Topics include the army nursing…

Orthopaedic techniques of Sabuncuoğlu in the 15th century Ottoman period.

PubMed

Sarban, Sezgin; Aksoy, Sahin; Uzel, Ilter; Işikan, Uğur E; Atik, Sahap

2005-10-01

Serefeddin Sabuncuoğlu (1385-1468) was the author of the surgical textbook Cerrahiyyetü'l-Haniyye (Imperial Surgery). It was the first illustrated surgical textbook in the Turkish-Islamic medical literature. Cerrahiyyetü'l-Haniyye is significant because it includes Sabuncuoğlu's color illustrations of surgical procedures, incisions, fracture dislocation reduction techniques, and instruments. There are only three handwritten copies. Two originally were written by Sabuncuoğlu and are exhibited in Paris and Istanbul. The book was rediscovered in 1936, but some parts are suspected to be missing. The book currently consists of three chapters divided into 193 sections. The third chapter includes orthopaedics and traumatology, reduction techniques of lower and upper extremities, fractures and dislocations, and relevant Greek, Arabic, and Persian textbooks are cited. Sabuncuoğlu also wrote about surgical treatment of congenital hand anomalies. He was the first to advise placing a wooden splint under the palmar side after hand surgery. We reviewed the sections of Cerrahiyyetü'l-Haniyye related to orthopaedics and traumatology. Compared with previous writings by Hippocrates, Ibn-i Sina, and Al-Zahrawi, there are no major differences in the treatment of fracture dislocations.

Results of a Textbook Survey Given in Introductory Astronomy

NASA Astrophysics Data System (ADS)

Willoughby, Shannon

2007-05-01

Textbooks are required for virtually all college science courses taught around the country, but whether students use them and find them valuable is not clear. In order to get a better idea about what the students thought of the textbook and how they spent their time using it, an anonymous survey was taken by 305 (out of 400) students enrolled in Physics 101 during the Fall semester of 2005. Developed and administered by www.textrev.com, this is a free survey that college faculty may use for physics and chemistry textbooks. This survey revealed two interesting points. First, although 75% of the students found the textbook to be moderately to very challenging, only 38% of students reported spending 2 or more hours per week reading the text. Reading was assigned the majority of class periods, with the intention that they would read the material before it was covered in class. Second, 81% of the students found that the end of chapter problems were moderately to very challenging, but 62% reported spending one hour or less per week working on the assigned questions. Homework was assigned regularly from the textbook for the first half of the class, after which point we experimented with an online homework system. Next semester a new textbook is being adopted for this class, which has no color pictures and is significantly slimmer than the current textbook. This textbook survey will be given again at the end of next semester to look for any changes in textbook usage.

Pruritus-Ani

MedlinePlus

... Dermatology and Pruritis Ani”. Chapter in Beck, D. E., Roberts, P. L., Saclarides, T. J., Senagore, A. J., Stamos, M. J., Wexner, S. D., Eds. ASCRS Textbook of Colon and Rectal Surgery, 2nd Edition. Springer, New York, NY; 2011. American Society of Colon ...

Effects of dietary cottonseed meal and iron-treated cottonseed meal in different laying hen genotypes.

PubMed

Panigrahi, S; Morris, T R

1991-03-01

The effects of dietary screw-pressed cottonseed meal (CSM) and iron-treated CSM on laying performance and discolourations in eggs were examined in a range of hen genotypes. In experiment 1, six genotypes, obtained at point-of-lay from various sources, were fed on a non-CSM diet, a diet with 300 g CSM/kg, and a diet containing iron-treated CSM at 300 g/kg. In experiment 2, two of these genotypes were reared together from day-old and were fed from 10 to 18 weeks on a non-CSM diet or a diet containing iron-treated CSM at 250 g/kg. They were then fed on a non-CSM layer diet or a diet containing iron-treated CSM at 300 g/kg, in a 2 x 2 x 2 factorial design that also examined the effects of the rearing diet. 2. The effects on food intakes and egg production of including CSM and iron-treated CSM in layer diets depended on the genotype of the hens. The strongest interaction between breed and diet was on food intake, the breed Hubbard Golden Comet (HGC) being the least tolerant of CSM and iron-treated CSM. 3. Inclusion of iron-treated CSM in the rearer diet to supply approximately 70% of the dietary protein had no adverse effects on growth or age at first egg. Food intake and egg production between 18 and 26 weeks were affected by the iron-treated CSM layer diet, but there were no carry-over effects attributable to the rearing diets. 4. Genotype was not a factor in the development of the gossypol-related brown yolk discolouration in fresh or warm-stored eggs of hens fed on a CSM-based diet containing 197 mg free gossypol/kg and 52 mg cyclopropenoid fatty acids (CPFA)/kg (experiment 1). 5. In both experiments, the susceptibility of eggs to the CPFA-related cold storage effects depended on the genotype of the hen, eggs from hens of the HCG breed being more affected than those of ISA hens. 6. Treatment of CSM with crystalline ferrous sulphate heptahydrate, at a 4:1 weight ratio of iron to free gossypol, prevented brown yolk discolourations in all genotypes tested, as assessed by subjecting egg yolks to atmospheres of ammonia, and cold storage of eggs.

Learner-Centered Teaching and Improving Learning by Writing Down the Statement of Problems in an Introductory Physics Course

NASA Astrophysics Data System (ADS)

Aurora, Tarlok

2005-04-01

In a calculus-based introductory physics course, students were assigned to write the statements of word problems (along with the accompanying diagrams if any), analyze these, identify important concepts/equations and try to solve these end-of- chapter homework problems. They were required to bring to class their written assignment until the chapter was completed in lecture. These were quickly checked at the beginning of the class. In addition, re-doing selected solved examples in the textbook were assigned as homework. Where possible, students were asked to look for similarities between the solved-examples and the end-of-the-chapter problems, or occasionally these were brought to the students' attention. It was observed that many students were able to solve several of the solved-examples on the test even though the instructor had not solved these in class. This was seen as an improvement over the previous years. It made the students more responsible for their learning. Another benefit was that it alleviated the problems previously created by many students not bringing the textbooks to class. It allowed more time for problem solving/discussions in class.

Jupiter: Lord of the Planets.

ERIC Educational Resources Information Center

Kaufmann, William

1984-01-01

Presents a chapter from an introductory college-level astronomy textbook in which full-color photographs and numerous diagrams highlight an extensive description of the planet Jupiter. Topics include Jupiter's geology, rotation, magnetic field, atmosphere (including clouds and winds), and the Great Red Spot. (DH)

Counseling the Gifted and Talented.

ERIC Educational Resources Information Center

Silverman, Linda Kreger, Ed.

This graduate-level textbook provides a framework for understanding giftedness, and considers the counseling process and strategies for counseling in the schools. Chapters include: "The Gifted Individual" (Linda Kreger Silverman); "The Quest for Meaning: Counseling Issues with Gifted Children and Adolescents" (Deirdre V. Lovecky); "A Developmental…

International Space Programs. Aerospace Education III.

ERIC Educational Resources Information Center

Air Univ., Maxwell AFB, AL. Junior Reserve Office Training Corps.

This curriculum guide is prepared for the Aerospace Education III series publication entitled "International Space Programs." The guide is organized according to specific chapters in the textbook. It provides guidelines for teachers in terms of objectives, behavioral objectives, suggested outlines, orientation, suggested key points,…

Introduction to United States Public Documents.

ERIC Educational Resources Information Center

Morehead, Joseph

This textbook, designed for use in library school government documents courses, provides an overview of the functions and characteristics of United States public documents. Chapters cover the Government Printing Office, the Superintendent of Documents, the depository library system, administration of documents collections, general guides to…

Managing a School's Fiscal and Physical Resources.

ERIC Educational Resources Information Center

Strahan, Richard D.

This chapter surveys a principal's risks and responsibilities in relation to managing school income from the following: co-curricular activities, expenditures for various equipment needs, property inventories, contracts issued for commemorative school items, custodianship of school textbooks, proceeds from merchandising certain items in school…

The paradigm that always was: Scientific discourse in Young-Earth Creationist textbooks

NASA Astrophysics Data System (ADS)

Maynard, Travis

Bob Jones University Press (BJU Press) is a publishing house owned by the Greenville, South Carolina university of the same name. Fulfilling Bob Jones' mission beyond the college classroom, BJU Press prints a full K-12 educational program that spans all subjects and meets national core content standards. These materials are nationally circulated in homeschooling environments and conservative Christian private schools, a growing portion of America's educational landscape: according to a Department of Education 2009 report, enrollment in these schools represented 885,000 students. Research in rhetoric facilitates our understanding of various discourse communities, especially those that appropriate the discourse of a separate community to forward an argument that runs counter to the purposes of the original community. An interesting example of this rhetorical strategy is BJU Press' educational philosophy called Biblical Integration, in which teachers are invoked to "call into question the secular assumptions of each subject and then encourage the student to rebuild the discipline from biblical presuppositions." Using this technique, teachers using BJU Press materials attempt to shape students' ideologies by teaching a literal reading of the Bible dictating a 6,000-year-old Earth. The most interesting subject area in which BJU Press deploys Biblical Integration is the natural sciences, wherein to achieve this goal, textbook authors must make two rhetorical moves: first, re-frame a biblical ideology as being equally scientific to its secular counterparts; and, second, argue for the superiority of a science based in the Bible. This thesis analyzes a science textbook produced by BJU Press, exploring how the authors meet these exigencies. Specifically, I argue that the authors of the eighth grade title Earth Science both adopt and adapt the discourse of science in order to validate Evangelical Christian Science as being legitimately engaged in scientific endeavors. Within the context of natural sciences, Biblical Integration is particularly compelling: in formulating an alternative view of science and arguing for its superiority over secular science, the authors at BJU Press are implicitly employing the discourse of Kuhnian scientific revolution, adding a layer of scientific credibility to their efforts by mimicking the historical progress of the sciences. In adopting a Kuhnian approach, the authors craft a hybrid discourse that blends science with scripture, working against the secular status quo of the sciences. Accordingly, to analyze this hybrid discourse, this thesis draws upon work within the rhetoric of science directly influenced by Thomas Kuhn. This analysis is conducted via two case studies. The first focuses on the textbook's introductory chapter, highlighting how the chapter appropriates the epistemological practices of scientific research by presenting an overarching argument that forwards a threefold purpose: (1) establishing the purpose of Christian Science; (2) highlighting the inherently ideological nature of scientific epistemology; and (3) providing a dualistic definition that polarizes Christian and secular science. By emphasizing the ideological nature of science, the authors of this textbook create a rhetorical space in which they can articulate their alternative view of science as being theoretically valid. The second case study analyzes a discipline-specific application of Christian Science: two textbook chapters that focus on geology. When the textbook attempts to operationalize Christian Science, this view falls short of the standards of science due to Evangelical faith in the infallibility of scripture. Despite this shortcoming, these two chapters still employ strategies indicative of Kuhnian paradigmatic arguments: highlighting fundamental anomalies in scientific consensus and utilizing arguments from familiarity to gain audiences' tentative acceptance. In using these argumentative strategies, the textbook authors mimic scientific argument, but do not fully meet the criteria of science.

Radiological Defense Manual.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Washington, DC.

Originally prepared for use as a student textbook in Radiological Defense (RADEF) courses, this manual provides the basic technical information necessary for an understanding of RADEF. It also briefly discusses the need for RADEF planning and expected postattack emergency operations. There are 14 chapters covering these major topics: introduction…

Propulsion Systems for Aircraft. Aerospace Education II. Instructional Unit II.

ERIC Educational Resources Information Center

Elmer, James D.

This curriculum guide accompanies another publication in the Aerospace Education II series entitled "Propulsion Systems for Aircraft." The guide includes specific guidelines for teachers on each chapter in the textbook. Suggestions are included for objectives (traditional and behavioral), suggested outline, orientation, suggested key…

Matematica 3. Manual.

ERIC Educational Resources Information Center

D'Alu, Maria Jose Miranda de Sousa

This teachers manual accompanies a mathematics textbook, written in Portuguese, for third graders. It closely follows the objectives and methodology of the major curricula used throughout the schools in the United States. The 11 chapters deal with: numeration (0-999,999); addition with and without regrouping; subtraction with and without…

School Business Administration.

ERIC Educational Resources Information Center

Jordan, K. Forbis; And Others

This textbook reviews the principal concerns within each of 13 major responsibility areas in school business administration. The first chapter assesses the political, social, and economic context in which schools function and school administrators work. The role and function of the school business administrator within this context is addressed in…

Introduction to Psychology. Fourth Edition.

ERIC Educational Resources Information Center

Kalat, James W.

Chapters in this textbook for college students in introductory psychology courses are: (1) What is Psychology?; (2) Scientific Methods in Psychology; (3) Biological Psychology; (4) Sensation and Perception; (5) Altered States; (6) Learning; (7) Memory; (8) Cognition and Language; (9) Intelligence and Its Measurement; (10) Development; (11)…

Discipline Based Instruction in Business Law

ERIC Educational Resources Information Center

Custin, Richard E.; Demas, John C.; Lampe, Marc; Custin, Colette L.

2013-01-01

Undergraduate business law courses typically utilize traditional textbooks organized by topic. Individual chapters, address the usual topics including contracts, torts, the court system and ethics. An innovative approach to facilitating a business law course involves segregating sections of the course into common business disciplines. Rather than…

The toxic effects of calories

USDA-ARS?s Scientific Manuscript database

This is a new chapter in the Graduate School textbook "Cassarett & Doull's Toxicology". It is intended as a teaching text for graduate students in toxicology departments and programs and for the examination for professional certification as a Diplomate of the American Board of Toxicology (D.A.B.T.)...

What Images Reveal: a Comparative Study of Science Images between Australian and Taiwanese Junior High School Textbooks

NASA Astrophysics Data System (ADS)

Ge, Yun-Ping; Unsworth, Len; Wang, Kuo-Hua; Chang, Huey-Por

2017-07-01

From a social semiotic perspective, image designs in science textbooks are inevitably influenced by the sociocultural context in which the books are produced. The learning environments of Australia and Taiwan vary greatly. Drawing on social semiotics and cognitive science, this study compares classificational images in Australian and Taiwanese junior high school science textbooks. Classificational images are important kinds of images, which can represent taxonomic relations among objects as reported by Kress and van Leeuwen (Reading images: the grammar of visual design, 2006). An analysis of the images from sample chapters in Australian and Taiwanese high school science textbooks showed that the majority of the Taiwanese images are covert taxonomies, which represent hierarchical relations implicitly. In contrast, Australian classificational images included diversified designs, but particularly types with a tree structure which depicted overt taxonomies, explicitly representing hierarchical super-ordinate and subordinate relations. Many of the Taiwanese images are reminiscent of the specimen images in eighteenth century science texts representing "what truly is", while more Australian images emphasize structural objectivity. Moreover, Australian images support cognitive functions which facilitate reading comprehension. The relationships between image designs and learning environments are discussed and implications for textbook research and design are addressed.

"A History of Us." An Excerpt.

ERIC Educational Resources Information Center

Hakim, Joy; And Others

1993-01-01

Introduces a new series of U.S. history textbooks geared to grade five (or grades four, five, and six). The 10-volume series, divided into short, manageable chapters, aims to make history come alive. An excerpt from Book 6 ("War, Terrible War") about the Civil War is presented. (SLD)

Human Requirements of Flight. Aerospace Education III. Instructional Unit IV.

ERIC Educational Resources Information Center

Hall, Arthur D.

This curriculum guide is prepared for the Aerospace Education III series publication entitled "Human Requirements of Flight." It provides specific guidelines for teachers using the textbook. The guidelines for each chapter are organized according to objectives (traditional and behavioral), suggested outline, orientation, suggested key…

The New Physical Optics Notebook: Tutorials in Fourier Optics.

ERIC Educational Resources Information Center

Reynolds, George O.; And Others

This is a textbook of Fourier optics for the classroom or self-study. Major topics included in the 38 chapters are: Huygens' principle and Fourier transforms; image formation; optical coherence theory; coherent imaging; image analysis; coherent noise; interferometry; holography; communication theory techniques; analog optical computing; phase…

The Law and Special Education.

ERIC Educational Resources Information Center

Yell, Mitchell L.

This textbook provides information on the legal development of special education, the current legal requirements in providing a free appropriate public education to students with disabilities, and the procedures involved in obtaining legal information in law libraries and on the Internet. Specifically, the 16 chapters address: (1) sources of law…

The Adult Experience.

ERIC Educational Resources Information Center

Belsky, Janet

The 14 chapters of this textbook chronicle adult development from youth through old age, emphasizing both research and interviews with adults at various stages in their lives. Topics covered include the following: (1) the academic field of adult development; (2) theories and research methods; (3) aging and disease prevention; (4) sexuality and…

BOOK REVIEW: Numerical Relativity: Solving Einstein's Equations on the Computer Numerical Relativity: Solving Einstein's Equations on the Computer

NASA Astrophysics Data System (ADS)

Gourgoulhon, Eric

2011-04-01

Numerical relativity is one of the major fields of contemporary general relativity and is developing continually. Yet three years ago, no textbook was available on this subject. The first textbook devoted to numerical relativity, by Alcubierre, appeared in 2008 [1] (cf the CQG review [2]). Now comes the second book, by Baumgarte and Shapiro, two well known players in the field. Inevitably, the two books have some common aspects (otherwise they would not deal with the same topic!). For instance the titles of the first four chapters of Baumgarte and Shapiro are very similar to those of Alcubierre. This arises from some logic inherent to the subject: chapter 1 recaps basic GR, chapter 2 introduces the 3+1 formalism, chapter 3 focuses on the initial data and chapter 4 on the choice of coordinates for the evolution. But there are also many differences between the two books, which actually make them complementary. At first glance the differences are the size (720 pages for Baumgarte and Shapiro vs 464 pages for Alcubierre) and the colour figures in Baumgarte and Shapiro. Regarding the content, Baumgarte and Shapiro address many topics which are not present in Alcubierre's book, such as magnetohydrodynamics, radiative transfer, collisionless matter, spectral methods, rotating stars and post-Newtonian approximation. The main difference regards binary systems: virtually absent from Alcubierre's book (except for binary black hole initial data), they occupy not less than five chapters in Baumgarte and Shapiro's book. In contrast, gravitational wave extraction, various hyperbolic formulations of Einstein's equations and the high-resolution shock-capturing schemes are treated in more depth by Alcubierre. In the first four chapters mentioned above, some distinctive features of Baumgarte and Shapiro's book are the beautiful treatment of Oppenheimer-Snyder collapse in chapter 1, the analogy with Maxwell's equations when discussing the constraints and the evolution equations in chapter 2 and the nice illustration of the 3+1 formalism by different slicings of Schwarzschild spacetime. Chapter 3, devoted to initial data, presents the York-Lichnerowicz conformal method with many details and examples, along with its descendants (extended conformal thin-sandwich). A very instructive illustration is provided by a boosted black hole. This chapter also introduces the recent waveless approximation and presents a rather detailed discussion of mass, momentum and angular momentum in the initial data. Chapter 4 contains a very pedagogical discussion of the choice of coordinates, via the lapse and shift functions, again with many examples. In particular, it provides the derivation of all maximal slicings of Schwarzschild spacetime, which is hardly found in any textbook. Chapter 5, devoted to matter sources, goes well beyond the ideal fluid generally discussed in the context of 3+1 numerical relativity: it also covers dissipative fluids, radiation hydrodynamics, collisionless matter and scalar fields. Chapter 6 provides a self-consistent introduction to the two main numerical methods used in numerical relativity: finite differences and spectral methods. It is followed by a very nice chapter about the various horizons involved in black hole spacetimes: event and apparent horizons, as well as dynamical and isolated horizons. One may, however, regret that there is no mention of Hayward's trapping horizons, which embody both dynamical and isolated horizons. Chapter 8 discusses in depth spherical spacetimes, including dynamical slicings of Schwarzschild, gravitational collapse of collisionless matter (26 pages!), collapse of fluid stars and scalar fields and critical phenomena. The main outcome of numerical relativity, gravitational waves, are introduced in a very pedagogical way in chapter 9, with the basic theory and a review of the astrophysical sources and detectors. Chapter 10, entirely devoted to the axisymmetric collapse of collisionless clusters, reflects clearly the research work of one of the authors, but it is also an opportunity to discuss the Cosmic Censorship conjecture and the Hoop conjecture. Chapter 11 presents the basics of hyperbolic systems and focuses on the famous BSSN formalism employed in most numerical codes. The electromagnetism analogy introduced in chapter 2 is developed, providing some very useful insight. The remainder of the book is devoted to the collapse of rotating stars (chapter 14) and to the coalescence of binary systems of compact objects, either neutron stars or black holes (chapters 12, 13, 15, 16 and 17). This is a unique introduction and review of results about the expected main sources of gravitational radiation. It includes a detailed presentation of the major triumph of numerical relativity: the successful computation of binary black hole merger. I think that Baumgarte and Shapiro have accomplished a genuine tour de force by writing such a comprehensive and self-contained textbook on a highly evolving subject. The primary value of the book is to be extremely pedagogical. The style is definitively at the textbook level and not that of a review article. One may point out the use of boxes to recap important results and the very instructive aspect of many figures, some of them in colour. There are also numerous exercises in the main text, to encourage the reader to find some useful results by himself. The pedagogical trend is manifest up to the book cover, with the subtitle explaining what the title means! Another great value of the book is indisputably its encyclopedic aspect, making it a very good starting point for research on many topics of modern relativity. I have no doubt that Baumgarte and Shapiro's monograph will quicken considerably the learning phase of any master or PhD student beginning numerical relativity. It will also prove to be very valuable for all researchers of the field and should become a major reference. Beyond numerical relativity, the richness and variety of examples are such that the reading of the book will be highly profitable to any person interested in black hole physics or relativistic astrophysics. This is not the least among all the merits of this superb book. References [1] Alcubierre M 2008 Introduction to 3+1 Numerical Relativity (Oxford: Oxford University Press) [2] Gundlach C 2008 Review of Introduction to 3+1 Numerical Relativity Class. Quantum Grav. 278 1270

Content, style, and emotional tone of texts in introductory psychology.

PubMed

Whissell, C M

1997-02-01

Random samples taken from six recent textbooks and three older books in introductory psychology were analyzed with respect to linguistic style, emotional tone, and pattern of citation. Newer and older books, individual books, and categories of chapters within books were compared to each other. Analysis suggests that newer books are longer and linguistically more complicated. They also contain proportionally more citations, and more text pages devoted to social psychology and psychopathology than older books. There were several significant stylistic and emotional differences among books and some significant content differences among chapters.

Nursery Production, A Student Handbook.

ERIC Educational Resources Information Center

Buckey, Sylvia; And Others

Developed by a group of university facilty members and graduate students, this textbook is designed for high school, technical school, and associate degree agricultural programs in the northeast section of the United States who study the nursery industry. Chapter topics, which include 84 subtopics, are: (1) Kinds of Nurseries, (2) Occupation in…

Communication. Listen, Speak, Write, Use.

ERIC Educational Resources Information Center

University of Northern Iowa, Cedar Falls. School of Business.

This instructional unit is intended for use in helping secondary and postsecondary business students develop their communications skills. The course is designed to be taught in six weeks in conjunction with the sixth edition of "Business English and Communication," a textbook published by McGraw-Hill. Chapters addressing listening, speaking,…

Practicing Good Habits, Grade 4.

ERIC Educational Resources Information Center

Van Cong Lau; And Others

This illustrated textbook was designed for teaching civics and values to fourth grade students in Vietnam. It is divided into six chapters: (1) At School (recapitulation of the grade three program, friendship, respect for the teacher, team work, discipline, honor); (2) In the Street: Traffic Regulations; (3) At Home (the extended family spirit,…

Matematica 2. Livro do Aluno (Mathematics 2. Student Workbook).

ERIC Educational Resources Information Center

D'Alu, Maria Jose Miranda de Sousa

This mathematics textbook, written in Portuguese, is designed for second graders. Developed from objectives set forth by the National Portuguese Materials Development Center, it follows closely the objectives and methodology of major curricula used in schools of the United States. The thirteen chapters deal with: numeration (0-999); addition with…

Teaching about Assessment in Professional Organizations

ERIC Educational Resources Information Center

Kurylo, Anastacia

2007-01-01

Students learning about professional communication are not often taught about assessment as indicated by its omission as a chapter topic in many major textbooks in the field. Nonetheless, students need to be educated on this topic because, increasingly, there is a push towards instituting assessment practices in business organizations.…

Sex And People.

ERIC Educational Resources Information Center

Jones, Kenneth L.; And Others

This textbook for the college student emphasizes human sexuality as a part of the whole human life experience and contains a balance of biological, psychological, and sociological material. In 16 chapters the following topics are covered: (1) sex and society; (2) historical and cultural perspectives; (3) glandular control of sexual physiology; (4)…

Teachers Discovering Computers: A Link to the Future, Web and CNN Turner Learning Enhanced. Shelly Cashman Series.

ERIC Educational Resources Information Center

Shelly, Gary B.; Cashman, Thomas J.; Gunter, Randolph E.; Gunter, Glenda A.

Intended for use in an introductory computer course for educators, this textbook contains the following chapters: (1) "Introduction to Using Computers in Education"; (2) "Communications, Networks, the Internet, and the World Wide Web"; (3) "Software Applications for Education,"; (4) "Hardware Applications for…

Unified Technical Concepts. Application Modules Volume II.

ERIC Educational Resources Information Center

Center for Occupational Research and Development, Inc., Waco, TX.

Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the second of two volumes, consists of 45 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force…

Basic Facts and Figures about the Educational System in Japan.

ERIC Educational Resources Information Center

National Inst. for Educational Research, Tokyo (Japan).

Tables, charts, and graphs convey supporting data that accompany text on various aspects of the Japanese educational system presented in this booklet. There are seven chapters: (1) Fundamental principles of education; (2) Organization of the educational system; (3) Basic statistics of education; (4) Curricula, textbooks, and instructional aids;…

The School Library Media Center.

ERIC Educational Resources Information Center

Prostano, Emanuel T.; Prostano, Joyce S.

With the aim of providing a realistic, professional approach to solving problems of administration, organization, and operation of the library media center, this textbook has been written for both practicing librarians as well as for students of library science. Included in the nine chapters are: an overview of terminology and the present state of…

The Plus or Minus Game--Teaching Estimation, Precision, and Accuracy

ERIC Educational Resources Information Center

Forringer, Edward R.; Forringer, Richard S.; Forringer, Daniel S.

2016-01-01

A quick survey of physics textbooks shows that many (Knight, Young, and Serway for example) cover estimation, significant digits, precision versus accuracy, and uncertainty in the first chapter. Estimation "Fermi" questions are so useful that there has been a column dedicated to them in "TPT" (Larry Weinstein's "Fermi…

Hispanic America to 1776. Globe Mosaic of American History.

ERIC Educational Resources Information Center

Lewin, Stephen, Ed.; And Others

This textbook examines Spanish exploration, conquest, settlement, and colonization of present-day Mexico, United States, and the Caribbean, and the conflicts and exchanges resulting from culture contact between Spaniards and Native Americans. Chapters cover: (1) first contacts in the Caribbean, enslavement of Native Americans, arrival of African…

Production and Space. The Global System, Level 3.

ERIC Educational Resources Information Center

Spicer, Brian, Ed.; And Others

Part of a geography series which stresses understanding of the environment through mastery of specific skills and concepts, the secondary level textbook investigates the interrelationships between humans and the goods they produce. The book is presented in 26 chapters organized around five main themes: (1) agricultural production, (2)…

Adulthood and Aging.

ERIC Educational Resources Information Center

Thomas, Jeanne L.

This textbook is designed to introduce undergraduates to the scientific study of aging in adults. Among the topics covered in the book's 15 chapters are: approaches to the study of adult development and aging (research methodology and related issues, a life-span perspective, ethical issues); theories in the study of adult development (models of…

The Environment: Issues and Choices for Society. Second Edition.

ERIC Educational Resources Information Center

ReVelle, Penelope; ReVelle, Charles

This textbook is recommended for use in introductory level Environmental Studies courses. The content and format are designed to accommodate students with various academic backgrounds and to allow for a variety of teaching approaches (such as lectures, discussions, and case studies). Generally, each chapter provides background information, a…

Culturally Relevant Pedagogy and the Public Speaking Classroom

ERIC Educational Resources Information Center

Colvin, Janet Weston; Tobler, Nancy

2012-01-01

From the earliest roots of rhetoric, practitioners emphasized the need for analyzing one's audience before developing a speech. Textbooks for most basic public speaking courses spend at least one chapter discussing audience analysis. Authors discuss adapting messages to various demographic, cultural, and individual differences. As a result,…

AV Instruction; Technology, Media, and Methods. Fifth Edition.

ERIC Educational Resources Information Center

Brown, James W.; And Others

This textbook provides an overview of media used for instruction and communication. Chapters cover the following subject areas: (1) media and the systematic approach to teaching and learning; (2) media and individualized learning; (3) the community as a learning center; (4) choosing, using, and producing media; (5) displaying, and some…

Teachers' Emotions and Classroom Effectiveness: Implications from Recent Research

ERIC Educational Resources Information Center

Sutton, Rosemary E.

2005-01-01

Cognition, motivation, and emotions are recognized by psychologists as the three fundamental classes of mental operations, yet most research in educational psychology has focused on the first two classes. Educational psychology textbooks for preservice teachers contain chapters on learning, problem solving, assessment, and motivation, but not on…

Health, Grade 5.

ERIC Educational Resources Information Center

Bui Van Bao; And Others

This is the fifth and last of the Vietnamese series of elementary health textbooks. This one was designed for fifth grade students in Vietnam. The thirty-five lessons are presented in the form of short stories with illustrations and a short summary. The four chapters cover the ordinary symptoms of illness, elementary notions of microbes and…

The Gentle Dissenter: Revisiting Annette Patterson's Research in English

ERIC Educational Resources Information Center

Mellor, Bronwyn

2017-01-01

In this special issue of "English in Australia" dedicated to Annette Patterson, Bronwyn Mellor reflects on this "gentle dissenter". Annette Patterson published articles, book chapters, and school textbooks in Australia, the USA, and the UK. Her incisive intellect and commitment to education probably meant that she was not ever…

Guidelines for applying the Composite Specification Model (CSM)

NASA Technical Reports Server (NTRS)

Agresti, William

1987-01-01

The Composite Specification Model (CSM) is an approach to representing software requirements. Guidelines are provided for applying CSM and developing each of the three descriptive views of the software: the contextual view, using entities and relationships; the dynamic view, using states and transitions; and the function view, using data flows and processes. Using CSM results in a software specification document, which is outlined.

Introduction to Elementary Particle Physics

NASA Astrophysics Data System (ADS)

Bettini, Alessandro

The Standard Model is the most comprehensive physical theory ever developed. This textbook conveys the basic elements of the Standard Model using elementary concepts, without the theoretical rigor found in most other texts on this subject. It contains examples of basic experiments, allowing readers to see how measurements and theory interplay in the development of physics. The author examines leptons, hadrons and quarks, before presenting the dynamics and the surprising properties of the charges of the different forces. The textbook concludes with a brief discussion on the recent discoveries of physics beyond the Standard Model, and its connections with cosmology. Quantitative examples are given, and the reader is guided through the necessary calculations. Each chapter ends in the exercises, and solutions to some problems are included in the book. Complete solutions are available to instructors at www.cambridge.org/9780521880213. This textbook is suitable for advanced undergraduate students and graduate students.

A Comprehensive Climate Science and Solutions Education Curriculum

NASA Astrophysics Data System (ADS)

Byrne, J. M.; Cook, J.; Little, L. J.; Peacock, K.; Sinclair, P.; Zeller, C.

2016-12-01

We are creating a broadly based curriculum for a multidisciplinary University/College course on climate change science and solutions. Climate change is a critical topic for all members of society and certainly for all students in postsecondary education. The curriculum will feature a wide range of topic presentations on the (i) science of climate change; and (ii) multidisciplinary solutions to climate change challenges. The end result will be an online textbook featuring short contributions from session participants and other invited specialists. First authors in this AGU Education Session will provide a 20-minute comprehensive lecture that will be recorded and shared as part of the online textbook. The recorded talks will be merged with author provided PowerPoint slides and appropriate high definition video footage to support the discussion, where possible. Authors will be asked to sign a waiver allowing the video recording to be part of the online textbook. Access to the videos and textbook chapters will be provided online to students registered in recognized university classes on climate change science and solutions for a modest fee.

Strong late-time circumstellar interaction in the peculiar supernova iPTF14hls

NASA Astrophysics Data System (ADS)

Andrews, Jennifer E.; Smith, Nathan

2018-06-01

We present a moderate-resolution spectrum of the peculiar Type II supernova (SN) iPTF14hls taken on day 1153 after discovery. This spectrum reveals the clear signature of shock interaction with dense circumstellar material (CSM). We suggest that this CSM interaction may be an important clue for understanding the extremely unusual photometric and spectroscopic evolution seen over the first 600 d of iPTF14hls. The late-time spectrum shows a double-peaked intermediate-width H α line indicative of expansion speeds around 1000 km s-1, with the double-peaked shape hinting at a disc-like geometry in the CSM. If the CSM were highly asymmetric, perhaps in a disc or torus that was ejected from the star 3-6 yr prior to explosion, the CSM interaction could have been overrun and hidden below the SN ejecta photosphere from a wide range of viewing angles. In that case, CSM interaction luminosity would have been thermalized well below the photosphere, potentially sustaining the high luminosity without exhibiting the traditional observational signatures of strong CSM interaction (narrow H α emission and X-rays). Variations in density structure of the CSM could account for the multiple rebrightenings of the light curve. We propose that a canonical 1 × 1051 erg explosion energy with enveloped CSM interaction as seen in some recent SNe, rather than an entirely new explosion mechanism, may be adequate to explain the peculiar evolution of iPTF14hls.

Cellulose/soy protein isolate composite membranes: evaluations of in vitro cytocompatibility with Schwann cells and in vivo toxicity to animals.

PubMed

Luo, Lihua; Gong, Wenrong; Zhou, Yi; Yang, Lin; Li, Daokun; Huselstein, Celine; Wang, Xiong; He, Xiaohua; Li, Yinping; Chen, Yun

2015-01-01

To evaluate the in vitro cytocompatibility of cellulose/soy protein isolate composite membranes (CSM) with Schwann cells and in vivo toxicity to animals. A series of cellulose/soy protein isolate composite membranes (CSM) were prepared by blending, solution casting and coagulation process. The cytocompatibility of the CSM to Schwann cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and by direct cells culture of Schwann cells on the surfaces of the CSM, respectively. The in vivo toxicity of the CSM to animals were also evaluated by acute toxicity testing, skin sensitization testing, pyrogen testing and intracutaneous stimulation testing, respectively, according to the ISO 10993 standard. The MTT assay showed that the cell viability of Schwann cells cultured in extracts from the CSM was higher than that from the neat cellulose membrane without containing SPI component. The direct cells culture indicated that the Schwann cells could attach and grow well on the surface of the CSM and the incorporation of SPI into cellulose contributed to improvement of cell adhesion and proliferation. The evaluations of in vivo biological safety suggested that the CSM showed no acute toxicity, no skin sensitization and no intracutaneous stimulation to the experimental animals. The CSM had in vitro cytocompatibility with Schwann cells and biological safety to animals, suggesting potential for the applications as nerve conduit for the repair of nerve defect.

Exploring the teaching and learning of clinical reasoning, risks, and benefits of cervical spine manipulation.

PubMed

Yamamoto, Katie; Condotta, Luca; Haldane, Chloe; Jaffrani, Sahar; Johnstone, Victoria; Jachyra, Patrick; Gibson, Barbara E; Yeung, Euson

2018-02-01

The aim of this study was to examine how risks and benefits of cervical spine manipulation (CSM) were framed and discussed in the context of mentorship and their impact on the perception of safe practice of CSM in clinical physiotherapy settings. A multi-method qualitative approach was employed, including a document analysis of established educational guidelines, observations of mentoring sessions, and individual face-to-face interviews with five mentees in the process of learning CSM, and four mentors with Orthopedic Manual Physical Therapy (OMPT) certification. Results demonstrated that participants' clinical decision-making processes to perform CSM were primarily oriented to the mitigation of risk. Achieving proficiency in the "science" of clinical reasoning and the "art" of "feel" related to mastering technical skills were viewed as means to mitigating risk and enhancing confidence to use CSM safely in clinical practice. While the "art" of technical skill mastery was of high importance to mentees and considered important to developing competency in performing CSM, it was discussed as distinct from their clinical reasoning processes. Thus, promoting a more balanced and integrated use of the "art" and "science" of safe practice for CSM in OMPT training may result in greater confidence and judicious use of CSM by physiotherapists.

Taiwan's experience in ocean education at the level of junior high school: a textbook-editing project of MEEP

NASA Astrophysics Data System (ADS)

Liu, C.-M.; Chen, I.-C.

2012-04-01

MEEP (Marine Education Enhancement Project) is a four-year pioneering project (Aug. 2008 to Jul. 2011) supported by Ministry of Education of Taiwan for the sake of spreading and deepening the ocean-related knowledge to the public as well as students at all universities and schools. MEEP covers several sub-projects which include the academic courses for college students either with or without marine background, the career training for students interested in ocean-related industries and shipbuilding, and the textbook editing for students from 6 to 18 years old. Among these sub-projects, the last one may be the most important because in Taiwan professional books containing ocean knowledge for younger students are quite few in the past. To this end, last year the authors completed a textbook entitled as "Ocean science, technology and history" suitable for students at junior high schools. Different from textbook used in universities and colleges, it requires more delicate means and vivid descriptions which are obviously beyond a professor's academic ability. Experiences the authors acquired in editing this textbook are represented herein. They include how the structure of chapters was chosen, how the figures for easy comprehension were painted, and how the difficult and hard sentences were translated to simple expressions.

Aging in community nutrition, diet therapy, and nutrition and aging textbooks.

PubMed

O'Neill, Peggy Schafer; Wellman, Nancy S; Himburg, Susan P; Johnson, Paulette; Elfenbien, Pamela

2005-01-01

Using content analysis, this study evaluated the aging content and context in 11 nutrition sub-specialty textbooks: community nutrition (n = 3), diet therapy (n = 4), and nutrition and aging (n = 4). Pages with paragraphs on aging were identified in community nutrition and diet therapy textbooks, and 10% random samples of pages were evaluated in nutrition and aging textbooks. Paragraphs were assigned to one of four categories: gerontology, nutrition as primary, nutrition as secondary, or tertiary prevention. A total of 310 pages was qualitatively analyzed using NUD*IST 5 software and quantitatively with percentages. Only 7% of community nutrition and 2% of diet therapy pages were devoted to aging. There was little integration of aging beyond the chapters on aging. Community nutrition had the most gerontology (30%) and primary prevention (43%) content. Diet therapy and nutrition and aging had more secondary prevention (33% and 42%, respectively) and tertiary prevention (27% each) content. Some important databases and studies were absent. Of the 1,239 ageism words, 10% were positive, 53% neutral, and 36% negative. Photographs were generally positive. Women, but not minorities, reflected current older adult demographics. Future textbook editions should address aging more comprehensively and positively to better prepare dietitians for the job market. Recommendations for authors, course instructors, and publishers are given.

Unified Technical Concepts. Application Modules Volume I.

ERIC Educational Resources Information Center

Center for Occupational Research and Development, Inc., Waco, TX.

Unified Technical Concepts (UTC) is a modular system for teaching applied physics in two-year postsecondary technician programs. This UTC laboratory textbook, the first of two volumes, consists of 56 learning modules dealing with basic concepts of physics. Addressed in the individual chapters of the guide are the following topics: force, work,…

Developing Competent Readers and Writers in the Middle Grades.

ERIC Educational Resources Information Center

Combs, Martha

This textbook is about engaging students from fourth through eighth grade in literacy experiences. It is intended to help teachers of adolescents expand their knowledge of this age group and explore ways of engaging these students in meaningful literacy learning. Part One (chapters 1-4) provides selected theoretical foundations for developmental…

Using an Authentic Radioisotope to Teach Half-Life

ERIC Educational Resources Information Center

Liddicoat, Scott; Sebranek, John

2005-01-01

Traditionally nuclear chemistry appears in the last few chapters of chemistry textbooks and is not normally considered a mainstream topic. In addition, some science teachers lack the training or equipment to teach nuclear chemistry. Yet nuclear chemistry is a very important topic that should be taught in all chemistry classrooms. Learning about…

Matematica 3. Livro do Aluno (Mathematics 3. Student Book).

ERIC Educational Resources Information Center

D'Alu, Maria Jose Miranda de Sousa

This mathematics textbook, written in Portuguese, is the third book of a Mathematics Program in Portuguese. It is designed for third graders. It closely follows the objectives and methodology of the major curricula used throughout the schools in the United States. The 11 chapters deal with: numeration (0-999,999); addition with and without…

Energy and the Environment. Second Edition.

ERIC Educational Resources Information Center

Fowler, John M.

This 17-chapter book (which may also be used as a textbook) provides a thorough insight into the basic facts about energy as well as new and transitional technologies such as synthetic fuels. The book also helps examine the economic, societal, and political aspects of the energy situation in detail, consistently providing technical data to support…

Electrician's Mate 3 & 2. Rate Training Manual and Nonresident Career Course.

ERIC Educational Resources Information Center

Gallant, Thomas E.; Hawley, John F.

This Rate Training Manual (Textbook) and Nonresident Career Course form a correspondence, self-study package to provide information related to tasks assigned to the Electrician's Mate Third and Second Class. Focus is on operating and maintaining power and lighting systems and associated equipment. The 16 chapters in the text are (1) The…

Taming the Chaos

ERIC Educational Resources Information Center

Johnson, Doug

2010-01-01

The ability to distract has put the use of laptops, netbooks, cell phones, PDAs, iPod/MP3 players, and portable game players on the banned list in many schools. Educators are discovering that students are more interested in online resources, such as Facebook, game sites, chat, and YouTube, than classroom lectures and textbook chapters about the…

Learning Algebra by Example in Real-World Classrooms

ERIC Educational Resources Information Center

Booth, Julie L.; Oyer, Melissa H.; Paré-Blagoev, E. Juliana; Elliot, Andrew J.; Barbieri, Christina; Augustine, Adam; Koedinger, Kenneth R.

2015-01-01

Math and science textbook chapters invariably supply students with sets of problems to solve, but this widely used approach is not optimal for learning; instead, more effective learning can be achieved when many problems to solve are replaced with correct and incorrect worked examples for students to study and explain. In the present study, the…

Handbook of Consultation: An Intervention for Advocacy and Outreach.

ERIC Educational Resources Information Center

Kurpius, DeWayne J., Ed.; Brown, Duane, Ed.

This handbook is one of four handbooks developed for preservice and inservice counselor preparation and professional development. It was developed as a practical guide for practicing professionals and as a textbook or supplementary material for use in courses or workshops on consultation. It consists of six chapters. "Introduction to Consultation:…

Operation of Wastewater Treatment Plants, Manual of Practice No. 11.

ERIC Educational Resources Information Center

Albertson, Orrie E.; And Others

This book is intended to be a reference or textbook on the operation of wastewater treatment plants. The book contains thirty-one chapters and three appendices and includes the description, requirements, and latest techniques of conventional unit process operation, as well as the symptoms and corrective measures regarding process problems. Process…

Systems Analysis for Librarians and Information Professionals. Second Edition. Library and Information Science Text Series.

ERIC Educational Resources Information Center

Osborne, Larry N.; Nakamura, Margaret

This textbook covering the basic techniques of systems analysis targeted to the librarian or information professional contains the following chapters: (1) Understanding Systems Analysis; (2) The Historical Development of Systems Analysis; (3) The Human Element; (4) Identifying and Defining Problems; (5) Collecting Data; (6) Analyzing and…

Teaching Case: Adapting the Access Northwind Database to Support a Database Course

ERIC Educational Resources Information Center

Dyer, John N.; Rogers, Camille

2015-01-01

A common problem encountered when teaching database courses is that few large illustrative databases exist to support teaching and learning. Most database textbooks have small "toy" databases that are chapter objective specific, and thus do not support application over the complete domain of design, implementation and management concepts…

Kanye West versus Kris Allen: Teaching Rhetorical Structure via Music

ERIC Educational Resources Information Center

Kaylor, Brian T.

2012-01-01

One important aspect of analyzing a rhetorical text is through consideration of the text or artifact's structure, which is why rhetorical criticism textbooks often devote a chapter to issues of structure, form, or genre. Such an emphasis should not be surprising since understanding rhetorical structure remains a foundational concept for rhetorical…

Biological Science: An Ecological Approach. BSCS Green Version. Teacher's Edition. Sixth Edition.

ERIC Educational Resources Information Center

Biological Sciences Curriculum Study, Colorado Springs.

This book is the teacher's edition to the 1987 edition of the Biological Sciences Curriculum Study Green Version textbook. It contains directions for teaching with this version, a description of the accompanying materials, teaching strategies by chapters, lists of useful software, safety guidelines, a materials list, chemical safety information,…

Teaching Self-Disclosure through an Activity Exploring Disclosure Research and Online Dating Sites

ERIC Educational Resources Information Center

Baker, Nicole Marie; Hastings, Sally O.

2013-01-01

Most interpersonal communication course textbooks include a section or chapter on the topic of self-disclosure. Students are normally introduced to elements of self-disclosure, such as a definition, functions, or reasons for self-disclosure, risks of self-disclosure, and the role of self-disclosure in relationships. Historically, research on…

A Review of: The Red-cockaded Woodpecker: Surviving in a Fire-Maintained Ecosystem

Treesearch

Kathleen E. Franzreb

2002-01-01

This is a comprehensive treatise on an endangered species that covers both the species' biology and its conservation and recovery. Organized in textbook fashion, the volume includes a review of the most important aspects of Red-cockaded Woodpecker (Picoides borealis) ecology and conservation. The 12 chapters cover this species' taxonomy,...

Theory into Practice--The Translation of Research Findings into the Classroom.

ERIC Educational Resources Information Center

Kennedy, Eileen

This paper discusses a research project that investigated the effectiveness of student surveys administered to eighth grade students on student involvement and learning. The surveys are called "Thinking About" and are presented at the beginning of each chapter in Core Science Textbooks. Two exercises were chosen for the study--chemical or physical…

Handicraft (Industrial Arts). Grades 4-5.

ERIC Educational Resources Information Center

Le Xuan Thuy

This is the second of two textbooks covering the elementary program in Vietnam on handicrafts and industrial arts. It is written for Vietnamese children at the fourth and fifth grade level. The four chapters are: (1) clay moulding, (2) use of ordinary carpentry tools, (3) book binding, and (4) miscellaneous. The course is designed to offer…

Ciencias 2 (Science 2). [Student's Workbook].

ERIC Educational Resources Information Center

Raposo, Lucilia

Ciencias 2 is the second in a series of elementary science textbooks written for Portuguese-speaking students. The text develops the basic skills that students need to study their surroundings and observe natural facts and phenomena by following scientific methods. The book is composed of 10 chapters and includes 57 lessons. Topics included are…

French for Marketing. Using French in Media and Communications.

ERIC Educational Resources Information Center

Batchelor, R. E.; Chebli-Saadi, M.

The textbook, entirely in French, is designed to help prepare anglophone students for French language usage in the media and telecommunications. It is organized according to two major themes. The first part addresses the French of advertising; chapter topics include the actors in advertising (agencies, announcers, supports), forms of advertising,…

Space in Change. The Global System, Level 2.

ERIC Educational Resources Information Center

Spicer, Brian, Ed.; And Others

Part of a geography series which stresses understanding of the environment through mastery of specific skills and concepts, the secondary level textbook examines how and why different environments have changed through time. The book is presented in eight chapters organized around the three main themes of change in local areas, land use, and the…

A Term Project in Visual Basic: The Downhill Snowboard Shop

ERIC Educational Resources Information Center

Simkin, Mark G.

2007-01-01

Most commercial programming applications are considerably more complex than the end-of-chapter exercises found in programming textbooks. This case addresses this problem by requiring the students in entry-level Visual Basic programming classes to create an application that helps users order ski equipment from a retailer. For convenience, the forms…

Teaching Special Relativity Without Calculus

NASA Astrophysics Data System (ADS)

Ruby, Lawrence

2009-04-01

I 2007 many AAPT members received a booklet that is the first chapter of a physics textbook available on a CD. This book espouses the new educational philosophy of teaching special relativity as the first item in the topic of mechanics. Traditionally, special relativity is part of one or more modern physics chapters at the end of the text,2 and very often this material is never utilized due to time constraints. From a logical standpoint, special relativity is important in satellite communications and in cosmology, as well as in modern physics applications such as atomic theory and high-energy physics. The purpose of this paper is to show that the new philosophy can be carried out in a noncalculus physics course, by demonstrating that all of the principal results of special relativity theory can be obtained by simple algebra. To accomplish this, we shall propose alternate derivations for two results that are usually obtained with calculus. Textbooks2 typically obtain the equations for time dilation and for length contraction from simple considerations based on Einstein's second postulate.3 We shall start from this point.

Evaluation of genetically-improved (glandless) and genetically-modified low-gossypol cottonseed meal as alternative protein sources in the diet of juvenile southern flounder Paralichthys lethostigma reared in a recirculating

USDA-ARS?s Scientific Manuscript database

Cottonseed meal (CSM) proteins from genetically-improved (glandless) seed (GI-CSM, 52.1% crude protein, CP), genetically-modified low-gossypol seed (GMO-CSM, 56.0% CP) and from an untreated regular (glanded) seed (R-CSM 49.9% CP) were evaluated to replace fish meal (FM) protein (59.5% CP) in juvenil...

Partners in Physics with Colorado School of Mines' Society of Physics Students

NASA Astrophysics Data System (ADS)

Moore, Shirley; Stilwell, Matthew; Boerner, Zach

2011-04-01

The Colorado School of Mines (CSM) Society of Physics Students (SPS) revitalized in 2008 and has since blown up with outreach activity, incorporating all age levels into our programs. In Spring 2010, CSM SPS launched a new program called Partners in Physics. Students from Golden High School came to CSM where they had a college-level lesson on standing waves and their applications. These students then joined volunteers from CSM in teaching local elementary school students about standing waves beginning with a science show. The CSM and high school students then helped the children to build make-and-take demonstrations incorporating waves. This year, rockets are the theme for Partners in Physics and we began with demonstrations with local middle school students. In Spring 2011, CSM SPS will be teaching elementary school students about projectile motion and model rockets along with these middle school students. Colorado School of Mines Department of Physics

Current Diagnosis and Management of Cervical Spondylotic Myelopathy.

PubMed

Bakhsheshian, Joshua; Mehta, Vivek A; Liu, John C

2017-09-01

Review. Cervical spondylotic myelopathy (CSM) is a major cause of disability, particular in elderly patients. Awareness and understanding of CSM is imperative to facilitate early diagnosis and management. This review article addresses CSM with regard to its epidemiology, anatomical considerations, pathophysiology, clinical manifestations, imaging characteristics, treatment approaches and outcomes, and the cost-effectiveness of surgical options. The authors performed an extensive review of the peer-reviewed literature addressing the aforementioned objectives. The clinical presentation and natural history of CSM is variable, alternating between quiescent and insidious to stepwise decline or rapid neurological deterioration. For mild CSM, conservative options could be employed with careful observation. However, surgical intervention has shown to be superior for moderate to severe CSM. The success of operative or conservative management of CSM is multifactorial and high-quality studies are lacking. The optimal surgical approach is still under debate, and can vary depending on the number of levels involved, location of the pathology and baseline cervical sagittal alignment. Early recognition and treatment of CSM, before the onset of spinal cord damage, is essential for optimal outcomes. The goal of surgery is to decompress the cord with expansion of the spinal canal, while restoring cervical lordosis, and stabilizing when the risk of cervical kyphosis is high. Further high-quality randomized clinical studies with long-term follow up are still needed to further define the natural history and help predict the ideal surgical strategy.

Proteomic analysis of cerebrospinal fluid in canine cervical spondylomyelopathy.

PubMed

Martin-Vaquero, Paula; da Costa, Ronaldo C; Allen, Matthew J; Moore, Sarah A; Keirsey, Jeremy K; Green, Kari B

2015-05-01

Prospective study. To identify proteins with differential expression in the cerebrospinal fluid (CSF) from 15 clinically normal (control) dogs and 15 dogs with cervical spondylomyelopathy (CSM). Canine CSM is a spontaneous, chronic, compressive cervical myelopathy similar to human cervical spondylotic myelopathy. There is a limited knowledge of the molecular mechanisms underlying these conditions. Differentially expressed CSF proteins may contribute with novel information about the disease pathogenesis in both dogs and humans. Protein separation was performed with 2-dimensional electrophoresis. A Student t test was used to detect significant differences between groups (P < 0.05). Three comparisons were made: (1) control versus CSM-affected dogs, (2) control versus non-corticosteroid-treated CSM-affected dogs, and (3) non-corticosteroid-treated CSM-affected versus corticosteroid-treated CSM-affected dogs. Protein spots exhibiting at least a statistically significant 1.25-fold change between groups were selected for subsequent identification with capillary-liquid chromatography tandem mass spectrometry. A total of 96 spots had a significant average change of at least 1.25-fold in 1 of the 3 comparisons. Compared with the CSF of control dogs, CSM-affected dogs demonstrated increased CSF expression of 8 proteins including vitamin D-binding protein, gelsolin, creatine kinase B-type, angiotensinogen, α-2-HS-glycoprotein, SPARC (secreted protein, acidic, rich in cysteine), calsyntenin-1, and complement C3, and decreased expression of pigment epithelium-derived factor, prostaglandin-H2 D-isomerase, apolipoprotein E, and clusterin. In the CSF of CSM-affected dogs, corticosteroid treatment increased the expression of haptoglobin, transthyretin isoform 2, cystatin C-like, apolipoprotein E, and clusterin, and decreased the expression of angiotensinogen, α-2-HS-glycoprotein, and gelsolin. Many of the differentially expressed proteins are associated with damaged neural tissue, bone turnover, and/or compromised blood-spinal cord barrier. The knowledge of the protein changes that occur in CSM and upon corticosteroid treatment of CSM-affected patients will aid in further understanding the pathomechanisms underlying this disease. N/A.

A circumcision method in an old surgical textbook (Cerrahiyyetul Haniyye): reminding of a forgotten procedure.

PubMed

Senayli, Atilla; Aksu, Murat; Atalar, Munir

2014-07-08

Circumcision is one of the historical surgical procedures. Some sources throughout the history contain various definitions about different circumcision methods. we described the details of the method, and aimed to remind the possibility of contemporary usage. We compared circumcision chapters of Sabuncuoglu and Zahrawi to explain the historical origin of Sabuncuoglu's favorite circumcision method. We found a method which might be summarized as "knotting with rope technique" in one of historical textbooks named as Cerrahiyyetul Haniyye (Imperial Surgery) written by Serefeddin Sabuncuoglu (1385-1468?) in 1465. This circumcision method is not used currently. In addition this method has not been defined in the history of medical literature yet.

Large-scale structural analysis: The structural analyst, the CSM Testbed and the NAS System

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Mccleary, Susan L.; Macy, Steven C.; Aminpour, Mohammad A.

1989-01-01

The Computational Structural Mechanics (CSM) activity is developing advanced structural analysis and computational methods that exploit high-performance computers. Methods are developed in the framework of the CSM testbed software system and applied to representative complex structural analysis problems from the aerospace industry. An overview of the CSM testbed methods development environment is presented and some numerical methods developed on a CRAY-2 are described. Selected application studies performed on the NAS CRAY-2 are also summarized.

Babies, child bearers and commodification: Anderson, Brazier et al., and the political economy of commercial surrogate motherhood.

PubMed

McLachlan, H V; Swales, J K

2000-01-01

It is argued by Anderson and also in the Brazier Report that Commercial Surrogate Motherhood (C.S.M.) contracts and agencies should be illegal on the grounds that C.S.M. involves the commodification of both mothers and babies. This paper takes issue with this view and argues that C.S.M. is not inconsistent with the proper respect for, and treatment of, children and women. A case for the legalization of C.S.M. is made.

RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System.

PubMed

Liu, Tina Y; Iavarone, Anthony T; Doudna, Jennifer A

2017-01-01

CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids. Type III-A systems use a multisubunit interference complex called Csm, containing Cas proteins and a CRISPR RNA (crRNA) to target cognate nucleic acids. The Csm complex is intriguing in that it mediates RNA-guided targeting of both RNA and transcriptionally active DNA, but the mechanism is not well understood. Here, we overexpressed the five components of the Thermus thermophilus (T. thermophilus) Type III-A Csm complex (TthCsm) with a defined crRNA sequence, and purified intact TthCsm complexes from E. coli cells. The complexes were thermophilic, targeting complementary ssRNA more efficiently at 65°C than at 37°C. Sequence-independent, endonucleolytic cleavage of single-stranded DNA (ssDNA) by TthCsm was triggered by recognition of a complementary ssRNA, and required a lack of complementarity between the first 8 nucleotides (5' tag) of the crRNA and the 3' flanking region of the ssRNA. Mutation of the histidine-aspartate (HD) nuclease domain of the TthCsm subunit, Cas10/Csm1, abolished DNA cleavage. Activation of DNA cleavage was dependent on RNA binding but not cleavage. This leads to a model in which binding of an ssRNA target to the Csm complex would stimulate cleavage of exposed ssDNA in the cell, such as could occur when the RNA polymerase unwinds double-stranded DNA (dsDNA) during transcription. Our findings establish an amenable, thermostable system for more in-depth investigation of the targeting mechanism using structural biology methods, such as cryo-electron microscopy and x-ray crystallography.

Magnetic resonance imaging features of Great Danes with and without clinical signs of cervical spondylomyelopathy

PubMed Central

Martin-Vaquero, Paula; da Costa, Ronaldo C.

2014-01-01

Objective To characterize and compare the MRI morphological features of the cervical vertebral column of Great Danes with and without clinical signs of cervical spondylomyelopathy (CSM). Design Prospective cohort study. Animals 30 Great Danes (15 clinically normal and 15 CSM-affected). Procedures All dogs underwent MRI of the cervical vertebral column (C2–3 through T1–2). Features evaluated included sites of subarachnoid space compression, spinal cord compression, or both; degree, cause, and direction of compression; MRI signal changes of the spinal cord; articular process (facet) joint characteristics; internal vertebral venous plexus visibility; and presence of extradural synovial cysts as well as presence and degree of intervertebral disk degeneration and foraminal stenosis. Results Clinically normal and CSM-affected dogs had 11 and 61 compressive sites, respectively, detected with MRI. All CSM-affected dogs had ≥ 1 site of spinal cord compression. No signal changes were observed in spinal cords of normal dogs, whereas 14 sites of hyperintensity were found in 9 CSM-affected dogs. Foraminal stenosis was present in 11 clinically normal and all CSM-affected dogs. The number of stenotic foraminal sites was significantly greater in the CSM-affected group, and severe stenosis appeared to be more common in this group than in the clinically normal group. Significant differences were identified between clinically normal and CSM-affected dogs with regard to amount of synovial fluid evident, regularity of articular surfaces, degree of articular process joint proliferation, and internal vertebral venous plexus visibility. Conclusions and Clinical Relevance Abnormalities were detected with MRI in several clinically normal Great Danes. Severe spinal cord compression, number of stenotic foraminal sites, and signal changes within the spinal cord distinguished CSM-affected from clinically normal Great Danes. PMID:25075822

Magnetic resonance imaging features of Great Danes with and without clinical signs of cervical spondylomyelopathy.

PubMed

Martin-Vaquero, Paula; da Costa, Ronaldo C

2014-08-15

To characterize and compare the MRI morphological features of the cervical vertebral column of Great Danes with and without clinical signs of cervical spondylomyelopathy (CSM). Prospective cohort study. 30 Great Danes (15 clinically normal and 15 CSM-affected). All dogs underwent MRI of the cervical vertebral column (C2-3 through T1-2). Features evaluated included sites of subarachnoid space compression, spinal cord compression, or both; degree, cause, and direction of compression; MRI signal changes of the spinal cord; articular process (facet) joint characteristics; internal vertebral venous plexus visibility; and presence of extradural synovial cysts as well as presence and degree of intervertebral disk degeneration and foraminal stenosis. Clinically normal and CSM-affected dogs had 11 and 61 compressive sites, respectively, detected with MRI. All CSM-affected dogs had ≥ 1 site of spinal cord compression. No signal changes were observed in spinal cords of normal dogs, whereas 14 sites of hyperintensity were found in 9 CSM-affected dogs. Foraminal stenosis was present in 11 clinically normal and all CSM-affected dogs. The number of stenotic foraminal sites was significantly greater in the CSM-affected group, and severe stenosis appeared to be more common in this group than in the clinically normal group. Significant differences were identified between clinically normal and CSM-affected dogs with regard to amount of synovial fluid evident, regularity of articular surfaces, degree of articular process joint proliferation, and internal vertebral venous plexus visibility. Abnormalities were detected with MRI in several clinically normal Great Danes. Severe spinal cord compression, number of stenotic foraminal sites, and signal changes within the spinal cord distinguished CSM-affected from clinically normal Great Danes.

Comparison of two matrix data structures for advanced CSM testbed applications

NASA Technical Reports Server (NTRS)

Regelbrugge, M. E.; Brogan, F. A.; Nour-Omid, B.; Rankin, C. C.; Wright, M. A.

1989-01-01

The first section describes data storage schemes presently used by the Computational Structural Mechanics (CSM) testbed sparse matrix facilities and similar skyline (profile) matrix facilities. The second section contains a discussion of certain features required for the implementation of particular advanced CSM algorithms, and how these features might be incorporated into the data storage schemes described previously. The third section presents recommendations, based on the discussions of the prior sections, for directing future CSM testbed development to provide necessary matrix facilities for advanced algorithm implementation and use. The objective is to lend insight into the matrix structures discussed and to help explain the process of evaluating alternative matrix data structures and utilities for subsequent use in the CSM testbed.

The Role of Children's Literature in One Rural Town's Elementary School: A Case Study.

ERIC Educational Resources Information Center

Altieri, Jennifer L.

1997-01-01

Surveys all 11 teachers in one rural setting to determine complexities surrounding literature use in that school. Finds the basal played a predominant role in classrooms--only the Chapter I teacher used literature during reading. Finds that "textbooks" were important for teachers and that trade books did not figure much in instruction.…

Public Employee Unionism: A Neglected Social Movement of the 1960s

ERIC Educational Resources Information Center

Shaffer, Robert

2011-01-01

The chapters on the 1960s and early 1970s in recent editions of secondary-level United States history textbooks have done an impressive job in getting beyond the traditional political narratives of presidential administrations to include the movements of protest and reform based on citizen activism. But despite their laudable efforts to broaden…

Earthquakes and Tsunamis. Pre-Elementary School Teacher's Guidebook [and] Pre-Elementary School Textbook.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France). Intergovernmental Oceanographic Commission.

This teacher's guide and student text present basic information about the causes and effects of earthquakes and tsunamis. The teacher's guide contains suggested activities, materials, and educational objectives for the text. Chapters in both texts are: (1) "Shapes and Movements of the Water"; (2) "Permeability and Buoyancy"; (3) "Life Styles at…

Reading Like a Historian: Teaching Literacy in Middle and High School History Classrooms

ERIC Educational Resources Information Center

Wineburg, Sam; Martin, Daisy; Monte-Sano, Chauncey

2011-01-01

Reaching beyond textbooks, this is a guide to teaching "historical reading" with middle and high school students. This practical resource shows you how to apply Sam Wineburg's highly acclaimed approach to teaching, "Reading Like a Historian", in your classroom to increase academic literacy and spark students' curiosity. Each chapter begins with an…

Our Only Homeland: An Ecological Look at the Land of the Gros Ventre and Assiniboine.

ERIC Educational Resources Information Center

Huberman, Robert G.; Huberman, Karen Pale Moon

This combined textbook and workbook examines the natural environment of the Hays/Lodgepole school district, and includes some general information about the Fort Belknap Indian Reservation. Chapter 1 describes the environment of the Little Rockies, the tribal forest management, tree diseases and infestations, logging, the effects of arson and…

An Investigation of Concept Mapping to Improve the Reading Comprehension of Science Texts

ERIC Educational Resources Information Center

Oliver, Kevin

2009-01-01

This study investigated how well 74 6th-grade science students represented text structures from a 900-word textbook chapter on soil conservation, given a concept map template with four superordinate terms and 24 unsorted concepts. Findings suggest students were more successful at classifying pre-selected terms under given superordinate categories…

I Find Out About Science. Grade 4.

ERIC Educational Resources Information Center

Center for Applied Linguistics, Arlington, VA.

This textbook is the fourth in the official science series developed by the Ministry of Education in Saigon and used in all public schools in Vietnam. The books in this series have been reprinted in their entirety from the original editions for use in American schools with Vietnamese students. The grade four text contains the following chapters:…

Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 7--Medical Emergencies. Revised.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

This training manual for emergency medical technicians, one of 14 modules that comprise the Emergency Victim Care textbook, covers medical emergencies. The objectives for the chapter are for students to be able to describe the causes, signs, and symptoms for specified medical emergencies and to describe emergency care for them. Informative…

Teaching and Learning at a Distance: Foundations of Distance Education.

ERIC Educational Resources Information Center

Simonson, Michael; Smaldino, Sharon; Albright, Michael; Zvacek, Susan

This book, which is an introductory-level textbook for preservice or inservice teachers, examines the foundations and practice of distance education (DE) and explains how to determine when DE is appropriate. The following are among the topics discussed in the book's 12 chapters: (1) foundations of DE (DE today and tomorrow, media in education,…

Teaching about Consumerism through Stories

ERIC Educational Resources Information Center

Haas, Kay Parks

2010-01-01

One of the best methods in the English language arts classroom is to educate students through the world of stories. The beauty of storytelling is that it often has a more powerful impact on young adults than a didactic lecture or a textbook chapter. Many times students would say that they internalize a message much more willingly through reading a…

Civil Aviation and Facilities. Aerospace Education II.

ERIC Educational Resources Information Center

Callaway, R. O.; Elmer, James D.

This is a revised textbook for use in the Air Force ROTC training program. The main theme of the book is concerned with the kinds of civil aviation facilities and many intricacies involved in their use. The first chapter traces the development of civil aviation and the formation of organizations to control aviation systems. The second chapter…

Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 11--Childbirth, Pediatric Emergencies. Revised.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

This training manual for emergency medical technicians, one of 14 modules that comprise the Emergency Victim Care textbook, covers childbirth and pediatric emergencies. Objectives stated for the two chapters are for the students to be able to describe: emergency procedures for normal childbirth, unusual childbirth emergencies, emergency care for…

Cramster: Friend or Foe?

ERIC Educational Resources Information Center

Grams, Michael

2011-01-01

Recently when teaching a first-semester calculus-based physics course for engineers, I was perplexed by a particular group of students. These individuals were able to solve nearly every homework problem assigned from the end-of-chapter exercises in our textbook, and in some cases were able to do so using methods that we had not covered in class.…

Technology's Impact on Graduate Level Reading: Using Technology to Improve Student Assignment Completion Rates

ERIC Educational Resources Information Center

Diamantes, Thomas

2007-01-01

This paper discusses the critical relation between professor, student and technology in the process of encouraging graduate students to read required textbook sections. It discusses how using online management software, graduate students are required to submit weekly chapter summaries to the professor by 5:00 pm on Fridays. In addition to the…

Surgery on varicose veins in the early Ottoman period performed by Serefeddin Sabuncuoğlu.

PubMed

Darçin, Osman Tansel; Andaç, Mehmet Halit

2003-07-01

Serefeddin Sabuncuoğlu, a pioneer of surgery, is known to be the author of first illustrated surgery textbook, Cerrahiyyetu'l Haniyye (Imperial Surgery), which was written in Turkish in 1465 AD at the age of 80 years. The purpose of this article is to describe his contributions to varicose vein surgery. In addition to vascular surgery, Serefeddin Sabuncuoğlu was interested in a wide range of surgical specialities including thoracic surgery, general surgery, pediatric surgery, ophthalmology, orthopedic surgery, urologic surgery, and obstetrics and gynecology. His book was the first illustrated textbook of surgery in the Turkish medical literature, containing color illustrations of surgical procedures, incisions, and instruments. The book has been known of for only the past 60 years. There are 137 different medical observations and recommendations in Cerrahiyyetu'l Haniyye, along with translated passages from the works of Ebu Kasim-ul Zahravi (Albucasis), Al-Tasrif (Textbook of Surgery), including Sabuncuoğlu's additional original contributions. In chapter 90 of the book, Sabuncuoğlu describes lower extremity varices and their surgical treatment and provides a few color illustrations. Although not recognized and rewarded in his time, Serefeddin Sabuncuoğlu was a great surgeon in Turkish-Islamic medical history. This review demonstrates that his textbook, Cerrahiyyetu'l Haniyye, was the first illustrated textbook including various surgical procedures, incisions, and instruments of varicose vein surgery.

Cognitive Style Mapping at Mt. Hood Community College.

ERIC Educational Resources Information Center

Keyser, John S.

1980-01-01

Describes Mount Hood Community College's experiences using the Modified Hill Model for Cognitive Style Mapping (CSM). Enumerates the nine dimensions of cognitive style assessed by the model. Discusses the value and limitations of CSM, five major checks on the validity of the model, and Mount Hood faculty's involvement with CSM. (AYC)

Exploring the Physics of Unstable Nuclei

NASA Astrophysics Data System (ADS)

Volya, Alexander

In this presentation the Continuum Shell Model (CSM) approach is advertised as a powerful theoretical tool for studying physics of unstable nuclei. The approach is illustrated using 17O as an example, which is followed by a brief presentation of the general CSM formalism. The successes of the CSM are highlighted and references are provided throughout the text. As an example, the CSM is applied perturbatively to 20O allowing one to explore the effects of continuum on positions of weakly bound states and low-lying resonances, as well as to discern some effects of threshold discontinuity.

Image Analysis Program for Measuring Particles with the Zeiss CSM 950 Scanning Electron Microscope (SEM)

DTIC Science & Technology

1990-01-01

7 𔄁 . ,: 1& *U _’ ś TECHNICAL REPORT AD NATICK/TR-90/014 (V) N* IMAGE ANALYSIS PROGRAM FOR MEASURING PARTICLES < WITH THE ZEISS CSM 950 SCANNING... image analysis program for measuring particles using the Zeiss CSM 950/Kontron system is as follows: A>CSM calls the image analysis program. Press D to...27 vili LIST OF TABLES TABLE PAGE 1. Image Analysis Program for Measuring 29 Spherical Particles 14 2. Printout of Statistical Data Frcm Table 1 16 3

CSM Testbed Development and Large-Scale Structural Applications

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Gillian, R. E.; Mccleary, Susan L.; Lotts, C. G.; Poole, E. L.; Overman, A. L.; Macy, S. C.

1989-01-01

A research activity called Computational Structural Mechanics (CSM) conducted at the NASA Langley Research Center is described. This activity is developing advanced structural analysis and computational methods that exploit high-performance computers. Methods are developed in the framework of the CSM Testbed software system and applied to representative complex structural analysis problems from the aerospace industry. An overview of the CSM Testbed methods development environment is presented and some new numerical methods developed on a CRAY-2 are described. Selected application studies performed on the NAS CRAY-2 are also summarized.

Command and Service Module Communications

NASA Technical Reports Server (NTRS)

Interbartolo, Michael

2009-01-01

This viewgraph presentation examines Command and Service Module (CSM) Communications. The communication system's capabilities are defined, including CSM-Earth, CSM-Lunar Module and CSM-Extravehicular crewman communications. An overview is provided for S-band communications, including data transmission and receiving rates, operating frequencies and major system components (pre-modulation processors, unified S-band electronics, S-band power amplifier and S-band antennas). Additionally, data transmission rates, operating frequencies and the capabilities of VHF communications are described. Major VHF components, including transmitters and receivers, and the VHF multiplexer and antennas are also highlighted. Finally, communications during pre-launch, ascent, in-flight and entry are discussed. Overall, the CSM communication system was rated highly by flight controllers and crew. The system was mostly autonomous for both crew and flight controllers and no major issues were encountered during flight.

Climate Change and Cerebrospinal Meningitis in the Ghanaian Meningitis Belt

PubMed Central

Codjoe, Samuel Nii Ardey; Nabie, Vivian Adams

2014-01-01

Cerebrospinal meningitis (CSM) is one of the infectious diseases likely to be affected by climate change. Although there are a few studies on the climate change-CSM nexus, none has considered perceptions of community members. However, understanding public perception in relation to a phenomenon is very significant for the design of effective communication and mitigation strategies as well as coping and adaptation strategies. This paper uses focus group discussions (FGDs) to fill this knowledge lacuna. Results show that although a few elderly participants ascribed fatal causes (disobedience to gods, ancestors, and evil spirits) to CSM infections during FGDs, majority of participants rightly linked CSM infections to dry, very hot and dusty conditions experienced during the dry season. Finally, community members use a suite of adaptation options to curb future CSM epidemics. PMID:25003550

Limitations of BCC_CSM's ability to predict summer precipitation over East Asia and the Northwestern Pacific

NASA Astrophysics Data System (ADS)

Gong, Zhiqiang; Dogar, Muhammad Mubashar Ahmad; Qiao, Shaobo; Hu, Po; Feng, Guolin

2017-09-01

This study examines the ability of the Beijing Climate Center Climate System Model (BCC_CSM) to predict the meridional pattern of summer precipitation over East Asia-Northwest Pacific (EA-NWP) and its East Asia-Pacific (EAP) teleconnection. The differences of summer precipitation modes of the empirical orthogonal function and the bias of atmospheric circulations over EA-NWP are analyzed to determine the reason for the precipitation prediction errors. Results indicate that the BCC_CSM could not reproduce the positive-negative-positive meridional tripole pattern from south to north that differs markedly from that observed over the last 20 years. This failure can be attributed to the bias of the BCC_CSM hindcasts of the summer EAP teleconnection and the low predictability of 500 hPa at the mid-high latitude lobe of the EAP. Meanwhile, the BCC_CSM hindcasts' deficiencies of atmospheric responses to SST anomalies over the Indonesia maritime continent (IMC) resulted in opposite and geographically shifted geopotential anomalies at 500 hPa as well as wind and vorticity anomalies at 850 hPa, rendering the BCC_CSM unable to correctly reproduce the EAP teleconnection pattern. Understanding these two problems will help further improve BCC_CSM's summer precipitation forecasting ability over EA-NWP.

Proteomic comparison by iTRAQ combined with mass spectrometry of egg white proteins in laying hens (Gallus gallus) fed with soybean meal and cottonseed meal

PubMed Central

He, Tao; Zhang, Haijun; Wang, Jing; Wu, Shugeng; Yue, Hongyuan; Qi, Guanghai

2017-01-01

Cottonseed meal (CSM) is commonly used in hens’ diets to replace soybean meal (SBM). However, the molecular consequences of this substitution remains unclear. To investigate the impact of this substitution at the molecular level, iTRAQ combined with biochemical analysis was performed in Hy-Line W-36 hens supplemented with a mixed diet of CSM and SBM. Egg weight, albumen height, and Haugh unit were significantly reduced in the CSM100 group (100% crude protein of SBM replaced by CSM) compared with the SBM group (P<0.05). A total of 15 proteins, accounting for 75% of egg white proteins with various biological functions of egg whites, were found to be reduced. This finding may relate to the decrease of albumen quality in the CSM100 group. Oviduct magnum morphology and hormone analysis indicated that a reduced level of plasma progesterone caused reduced growth of the tubular gland and epithelial cells in the magnum, further decreasing egg white protein synthesis in the magnum. These findings help demonstrate the molecular mechanisms of a CSM diet that cause adverse effects on albumen quality, while also showing that SBM should not be totally replaced with CSM in a hen diet. PMID:28813468

Modeling Type II-P/II-L Supernovae Interacting with Recent Episodic Mass Ejections from Their Presupernova Stars with MESA and SNEC

NASA Astrophysics Data System (ADS)

Das, Sanskriti; Ray, Alak

2017-12-01

We show how dense, compact, discrete shells of circumstellar gas immediately outside of red supergiants affect the optical light curves of Type II-P/II-L supernovae (SNe), using the example of SN 2013ej. Earlier efforts in the literature had used an artificial circumstellar medium (CSM) stitched to the surface of an evolved star that had not gone through a phase of late-stage heavy mass loss, which, in essence, is the original source of the CSM. In contrast, we allow enhanced mass-loss rate from the modeled star during the 16O and 28Si burning stages and construct the CSM from the resulting mass-loss history in a self-consistent way. Once such evolved pre-SN stars are exploded, we find that the models with early interaction between the shock and the dense CSM reproduce light curves far better than those without that mass loss and, hence, having no nearby dense CSM. The required explosion energy for the progenitors with a dense CSM is reduced by almost a factor of two compared to those without the CSM. Our model, with a more realistic CSM profile and presupernova and explosion parameters, fits observed data much better throughout the rise, plateau, and radioactive tail phases as compared to previous studies. This points to an intermediate class of supernovae between Type II-P/II-L and Type II-n SNe with the characteristics of simultaneous UV and optical peak, slow decline after peak, and a longer plateau.

Modified carotid sinus massage using an ultrasonography for maximizing vagal tone: a crossover simulation study.

PubMed

Ha, Seung Min; Cho, Young Suk; Cho, Gyu Chong; Jo, Choong Hyun; Ryu, Ji Young

2015-07-01

The aim of this study was to ascertain if a modified carotid sinus massage (CSM) using ultrasonography is superior to the conventional CSM for vagal tone generation. This was a prospective, crossover, clinical trial including 30 subjects with sinus rhythm. Participants were paired, and they performed 2 types of CSM to each other. To perform the conventional technique, pressure was exerted at the point where the maximal impulse of the carotid pulse was palpated. In the modified technique, participants localized the point of maximal diameter just above the bifurcation of the common carotid artery using ultrasonography and applied pressure to that point. Mean differences between premaneuver and postmaneuver R-R intervals and heart rates were compared. The distance from the midline of the neck (x distance) to the angle of the mandible (y distance) was measured, and the mean distance between the 2 techniques was compared. The baseline mean premaneuver R-R interval and heart rate did not differ significantly between the 2 techniques. The postmaneuver R-R interval and heart rate as well as the mean R-R interval and heart rate differences were significantly greater in the modified CSM. The mean location determined using the modified CSM was located 0.8 cm lateral and 0.8 cm superior to the mean location of the conventional CSM. The modified CSM using ultrasonography might be more useful than the conventional CSM in reverting episodes of paroxysmal supraventricular tachycardia and may be a suitable alternative for treating the same in the emergency department. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Ancillary outcome measures for assessment of individuals with cervical spondylotic myelopathy.

PubMed

Kalsi-Ryan, Sukhvinder; Singh, Anoushka; Massicotte, Eric M; Arnold, Paul M; Brodke, Darrel S; Norvell, Daniel C; Hermsmeyer, Jeffrey T; Fehlings, Michael G

2013-10-15

Narrative review. To identify suitable outcome measures that can be used to quantify neurological and functional impairment in the management of cervical spondylotic myelopathy (CSM). CSM is the leading cause of acquired spinal cord disability, causing varying degrees of neurological impairment which impact on independence and quality of life. Because this impairment can have a heterogeneous presentation, a single outcome measure cannot define the broad range of deficits seen in this population. Therefore, it is necessary to define outcome measures that characterize the deficits with greater validity and sensitivity. This review was conducted in 3 stages. Stage I: To evaluate the current use of outcome measures in CSM, PubMed was searched using the name of the outcome measure and the common abbreviation combined with "CSM" or "myelopathy." Stage II: Having identified a lack of appropriate outcome measures, we constructed criteria by which measures appropriate for assessing the various aspects of CSM could be identified. Stage III: A second literature search was then conducted looking at specified outcomes that met these criteria. All literature was reviewed to determine specificity and psychometric properties of outcomes for CSM. Nurick grade, modified Japanese Orthopaedic Association Scale, visual analogue scale (VAS) for pain, Short Form (36) Health Survey (SF-36), and Neck Disability Index were the most commonly cited measures. The Short-Form 36 Health Survey and Myelopathy Disability Index have been validated in the CSM population with multiple studies, whereas the modified Japanese Orthopaedic Association Scale score, Nurick grade, and European Myelopathy Scale each had only one study assessing psychometric characteristics. No validity, reliability, or responsiveness studies were found for the VAS or Neck Disability Index in the CSM population. We recommend that the modified Japanese Orthopaedic Association Scale, Nurick grade, Myelopathy Disability Index, Neck Disability Index, and 30-Meter Walk Test are most appropriate for the assessment of CSM. However, 6 additional outcome measures (QuickDASH, Berg Balance Scale, Graded Redefined Assessment of Strength Sensibility and Prehension, Grip Dynamometer, and GAITRite Analysis) were identified, which provide complementary assessments for CSM. SUMMARY STATEMENTS: There does not exist a single or composite of outcome instruments that measures myelopathy impairment, function/disability, and participation that have also demonstrated reliability, validity, and responsiveness in a CSM population. More work in the development and psychometric evaluation of new or existing measures is necessary to identify the ideal composite of measures to be used in the clinical and research settings. The mJOA, Nurick grade, NDI, MDI, and 30MWT should be adopted in any clinical practice that treats CSM both for screening and clinical follow-up. We propose that clinicians and researchers consider using the ancillary measures identified, such as the QuickDASH, Berg Balance Scale, GRASSP version 1.0, Grip Strength, and GAITRite Analysis. It is highly recommended that baseline and follow-up measurements should be performed in patients with CSM.

Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 13--Extrication from Automobiles. Revised.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

This training manual for emergency medical technicians, one of 14 modules that comprise the Emergency Victim Care textbook, covers extrication of victims from automobiles. Objectives stated for the chapter are for the student to be able to describe how to use extrication equipment properly and the correct use of the long and short backboards to…

The More Things Change, the More They Stay the Same: Excavating Race and the Enduring Racisms in U.S. Curriculum

ERIC Educational Resources Information Center

Brown, Anthony L.; Brown, Keffrelyn D.

2015-01-01

Drawing from the theories of racial formation theory and race marking, this chapter explores the durability of racial discourses in school curriculum over time in the United States. The authors' inquiry focuses on racial discourses located in two sources of curricula knowledge: children's literature and U.S. history textbooks.

Thinking Evolutionarily: Evolution Education across the Life Sciences--Summary of a Convocation

ERIC Educational Resources Information Center

Olson, Steve

2012-01-01

Evolution is the central unifying theme of biology. Yet today, more than a century and a half after Charles Darwin proposed the idea of evolution through natural selection, the topic is often relegated to a handful of chapters in textbooks and a few class sessions in introductory biology courses, if covered at all. In recent years, a movement has…

Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 8--Crisis Intervention, Drug-Related Problems. Revised.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

This training manual for emergency medical technicians, one of 14 modules that comprise the Emergency Victim Care textbook, covers crisis intervention and drug related problems. Objectives stated for the two chapters are for the student to be able to describe: treating common mental disturbances, relating to those suffering a crisis in a…

Practical Law in Utah. Utah Supplement to "Street Law." Fourth Edition.

ERIC Educational Resources Information Center

Utah State Office of Education, Salt Lake City. Statewide Clearinghouse on Law-Related Education.

This textbook for high school students on law in Utah supplements "Street Law: A Course in Practical Law," a program in law-related education in use across the United States. The introduction explains the meaning of law, how laws are made in Utah, and the functions of the state court system. Following chapters elucidate the branches of…

Can I improve postoperative outcome after abdominal surgery?

PubMed

Lauwick, S; Kaba, A; Joris, J

2007-01-01

Most of the textbooks of anesthesia do not devote any chapter to anesthesia for abdominal surgery. Whereas the choice of anesthetics has minimal impact on postoperative outcome of the patient scheduled for these procedures global perioperative anesthetic management however affects postoperative recovery, convalescence, or even morbidity. This presentation highlights practical measures susceptible of reducing postoperative complications and of shortening patient convalescence.

The Textalk, A Uniquely Simple, Versatile Type of Audio-Visual Module: How to Prepare and Use It.

ERIC Educational Resources Information Center

Thomas, D. Des S.; Habowsky, J. E. J.

Textbooks emphasizing visual elements in exposition can be enriched using crisp, concise, audio-taped commentaries to focus attention on essential points in each illustration. These text aids, packaged in the convenient form of cassettes (usually one per chapter), have a number of obvious advantages: (1) any teacher can prepare them; (2) they are…

Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 12. Water Accidents, Electrical Emergencies, Hazardous Materials and Radiation Accidents. Revised.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

This training manual for emergency medical technicians, one of 14 modules that comprise the Emergency Victim Care textbook, covers water accidents, electrical emergencies, and hazardous materials and radiation accidents. Objectives stated for the three chapters are for the students to be able to describe: emergency care for specified water…

BOOK REVIEW: String Theory in a Nutshell

NASA Astrophysics Data System (ADS)

Skenderis, Kostas

2007-11-01

The book 'String Theory in a Nutshell' by Elias Kiritsis provides a comprehensive introduction to modern string theory. String theory is the leading candidate for a theory that successfully unifies all fundamental forces of nature, including gravity. The subject has been continuously developing since the early 1970s, with classic textbooks on the subject being those of Green, Schwarz and Witten (1987) and Polchinski (1998). Since the latter was published there have been substantial developments, in particular in understanding black holes and gravity/gauge theory dualities. A textbook treatment of this important material is clearly needed, both by students and researchers in string theory and by mathematicians and physicists working in related fields. This book has a good selection of material, starting from basics and moving into classic and modern topics. In particular, Kiritsis' presentation of the basic material is complementary to that of the earlier textbooks and he includes a number of topics which are not easily found or covered adequately elsewhere, for example, loop corrections to string effective couplings. Overall the book nicely covers the major advances of the last ten years, including (non-perturbative) string dualities, black hole physics, AdS/CFT and matrix models. It provides a concise but fairly complete introduction to these subjects which can be used both by students and by researchers. Moreover the emphasis is on results that are reasonably established, as is appropriate for a textbook; concise summaries are given for subjects which are still in flux, with references to relevant reviews and papers. A positive feature of the book is that the bibliography sections at the end of each chapter provide a comprehensive guide to the literature. The bibliographies point to reviews and pedagogical papers on subjects covered in this book as well as those that were omitted. It is rare for a textbook to contain such a self-contained and detailed guide to the literature. In all, the book contains nearly five hundred exercises for the graduate-level student, which are useful both in teaching courses on string theory and for those who are studying by themselves. A nice feature of this book is that references are made to specific pages earlier in the book, rather than to chapters, which is helpful for students working through the book on their own. In summary,'String Theory in a Nutshell'is a valuable addition to the existing string theory textbooks; it is complementary to the previous books and gives a good treatment of subsequent developments. It is likely to become a staple reference on the subject, used both by students and researchers.

Fundamentals of Geophysics

NASA Astrophysics Data System (ADS)

Lowrie, William

1997-10-01

This unique textbook presents a comprehensive overview of the fundamental principles of geophysics. Unlike most geophysics textbooks, it combines both the applied and theoretical aspects to the subject. The author explains complex geophysical concepts using abundant diagrams, a simplified mathematical treatment, and easy-to-follow equations. After placing the Earth in the context of the solar system, he describes each major branch of geophysics: gravitation, seismology, dating, thermal and electrical properties, geomagnetism, paleomagnetism and geodynamics. Each chapter begins with a summary of the basic physical principles, and a brief account of each topic's historical evolution. The book will satisfy the needs of intermediate-level earth science students from a variety of backgrounds, while at the same time preparing geophysics majors for continued study at a higher level.

Comparisons Between Experimental and Semi-theoretical Cutting Forces of CCS Disc Cutters

NASA Astrophysics Data System (ADS)

Xia, Yimin; Guo, Ben; Tan, Qing; Zhang, Xuhui; Lan, Hao; Ji, Zhiyong

2018-05-01

This paper focuses on comparisons between the experimental and semi-theoretical forces of CCS disc cutters acting on different rocks. The experimental forces obtained from LCM tests were used to evaluate the prediction accuracy of a semi-theoretical CSM model. The results show that the CSM model reliably predicts the normal forces acting on red sandstone and granite, but underestimates the normal forces acting on marble. Some additional LCM test data from the literature were collected to further explore the ability of the CSM model to predict the normal forces acting on rocks of different strengths. The CSM model underestimates the normal forces acting on soft rocks, semi-hard rocks and hard rocks by approximately 38, 38 and 10%, respectively, but very accurately predicts those acting on very hard and extremely hard rocks. A calibration factor is introduced to modify the normal forces estimated by the CSM model. The overall trend of the calibration factor is characterized by an exponential decrease with increasing rock uniaxial compressive strength. The mean fitting ratios between the normal forces estimated by the modified CSM model and the experimental normal forces acting on soft rocks, semi-hard rocks and hard rocks are 1.076, 0.879 and 1.013, respectively. The results indicate that the prediction accuracy and the reliability of the CSM model have been improved.

3D printing of Mg-substituted wollastonite reinforcing diopside porous bioceramics with enhanced mechanical and biological performances.

PubMed

He, Dongshuang; Zhuang, Chen; Xu, Sanzhong; Ke, Xiurong; Yang, Xianyan; Zhang, Lei; Yang, Guojing; Chen, Xiaoyi; Mou, Xiaozhou; Liu, An; Gou, Zhongru

2016-09-01

Mechanical strength and its long-term stability of bioceramic scaffolds is still a problem to treat the osteonecrosis of the femoral head. Considering the long-term stability of diopside (DIO) ceramic but poor mechanical strength, we developed the DIO-based porous bioceramic composites via dilute magnesium substituted wollastonite reinforcing and three-dimensional (3D) printing. The experimental results showed that the secondary phase (i.e. 10% magnesium substituting calcium silicate; CSM10) could readily improve the sintering property of the bioceramic composites (DIO/CSM10- x , x  = 0-30) with increasing the CSM10 content from 0% to 30%, and the presence of the CSM10 also improved the biomimetic apatite mineralization ability in the pore struts of the scaffolds. Furthermore, the flexible strength (12.5-30 MPa) and compressive strength (14-37 MPa) of the 3D printed porous bioceramics remarkably increased with increasing CSM10 content, and the compressive strength of DIO/CSM10-30 showed a limited decay (from 37 MPa to 29 MPa) in the Tris buffer solution for a long time stage (8 weeks). These findings suggest that the new CSM10-reinforced diopside porous constructs possess excellent mechanical properties and can potentially be used to the clinic, especially for the treatment of osteonecrosis of the femoral head work as a bioceramic rod.

Against the Wind: Radio Light Curves of Type IA Supernovae Interacting with Low-Density Circumstellar Shells

DOE PAGES

Harris, Chelsea E.; Nugent, Peter E.; Kasen, Daniel N.

2016-05-26

For decades a wide variety of observations spanning the radio through optical and on to the X-ray have attempted to uncover signs of type Ia supernovae (SNe Ia) interacting with a circumstellar medium (CSM). The goal of these studies is to constrain the nature of the hypothesized SN Ia mass-donor companion. A continuous CSM is typically assumed when interpreting observations of interaction. However, while such models have been successfully applied to core-collapse SNe, the assumption of continuity may not be accurate for SNe Ia, because shells of CSM could be formed by pre-supernova eruptions (novae). In this work, we modelmore » the interaction of SNe with a spherical, low-density, finite-extent CSM and create a suite of synthetic radio synchrotron light curves. We find that CSM shells produce sharply peaked light curves. We also identify a fiducial set of models that obey a common evolution and can be used to generate radio light curves for an interaction with an arbitrary shell. The relations obeyed by the fiducial models can be used to deduce CSM properties from radio observations; we demonstrate this by applying them to the nondetections of SN 2011fe and SN 2014J. Finally, we explore a multiple shell CSM configuration and describe its more complicated dynamics and the resultant radio light curves.« less

AGAINST THE WIND: RADIO LIGHT CURVES OF TYPE IA SUPERNOVAE INTERACTING WITH LOW-DENSITY CIRCUMSTELLAR SHELLS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, Chelsea E.; Nugent, Peter E.; Kasen, Daniel N., E-mail: chelseaharris@berkeley.edu

2016-06-01

For decades a wide variety of observations spanning the radio through optical and on to the X-ray have attempted to uncover signs of type Ia supernovae (SNe Ia) interacting with a circumstellar medium (CSM). The goal of these studies is to constrain the nature of the hypothesized SN Ia mass-donor companion. A continuous CSM is typically assumed when interpreting observations of interaction. However, while such models have been successfully applied to core-collapse SNe, the assumption of continuity may not be accurate for SNe Ia, because shells of CSM could be formed by pre-supernova eruptions (novae). In this work, we modelmore » the interaction of SNe with a spherical, low-density, finite-extent CSM and create a suite of synthetic radio synchrotron light curves. We find that CSM shells produce sharply peaked light curves. We also identify a fiducial set of models that obey a common evolution and can be used to generate radio light curves for an interaction with an arbitrary shell. The relations obeyed by the fiducial models can be used to deduce CSM properties from radio observations; we demonstrate this by applying them to the nondetections of SN 2011fe and SN 2014J. Finally, we explore a multiple shell CSM configuration and describe its more complicated dynamics and the resultant radio light curves.« less

Chitin Synthases with a Myosin Motor-Like Domain Control the Resistance of Aspergillus fumigatus to Echinocandins

PubMed Central

Jiménez-Ortigosa, Cristina; Aimanianda, Vishukumar; Muszkieta, Laetitia; Mouyna, Isabelle; Alsteens, David; Pire, Stéphane; Beau, Remi; Krappmann, Sven; Beauvais, Anne; Dufrêne, Yves F.

2012-01-01

Aspergillus fumigatus has two chitin synthases (CSMA and CSMB) with a myosin motor-like domain (MMD) arranged in a head-to-head configuration. To understand the function of these chitin synthases, single and double csm mutant strains were constructed and analyzed. Although there was a slight reduction in mycelial growth of the mutants, the total chitin synthase activity and the cell wall chitin content were similar in the mycelium of all of the mutants and the parental strain. In the conidia, chitin content in the ΔcsmA strain cell wall was less than half the amount found in the parental strain. In contrast, the ΔcsmB mutant strain and, unexpectedly, the ΔcsmA/ΔcsmB mutant strain did not show any modification of chitin content in their conidial cell walls. In contrast to the hydrophobic conidia of the parental strain, conidia of all of the csm mutants were hydrophilic due to the presence of an amorphous material covering the hydrophobic surface-rodlet layer. The deletion of CSM genes also resulted in an increased susceptibility of resting and germinating conidia to echinocandins. These results show that the deletion of the CSMA and CSMB genes induced a significant disorganization of the cell wall structure, even though they contribute only weakly to the overall cell wall chitin synthesis. PMID:22964252

Application developer's tutorial for the CSM testbed architecture

NASA Technical Reports Server (NTRS)

Underwood, Phillip; Felippa, Carlos A.

1988-01-01

This tutorial serves as an illustration of the use of the programmer interface on the CSM Testbed Architecture (NICE). It presents a complete, but simple, introduction to using both the GAL-DBM (Global Access Library-Database Manager) and CLIP (Command Language Interface Program) to write a NICE processor. Familiarity with the CSM Testbed architecture is required.

PTF11kx: A Type Ia Supernova with Hydrogen Emission Persisting after 3.5 Years

DOE PAGES

Graham, M. L.; Harris, C. E.; Fox, O. D.; ...

2017-07-11

The optical transient PTF11kx exhibited both the characteristic spectral features of Type Ia supernovae (SNe Ia) and the signature of ejecta interacting with circumstellar material (CSM) containing hydrogen, indicating the presence of a nondegenerate companion. In this paper, we present an optical spectrum at 1342 days after peak from Keck Observatory, in which the broad component of Hα emission persists with a similar profile as in early-time observations. We also present Spitzer IRAC detections obtained 1237 and 1818 days after peak, and an upper limit from Hubble Space Telescope ultraviolet imaging at 2133 days. We interpret our late-time observations inmore » the context of published results—and reinterpret the early-time observations—in order to constrain the CSM's physical parameters and to compare to theoretical predictions for recurrent-nova systems. We find that the CSM's radial extent may be several times the distance between the star and the CSM's inner edge, and that the CSM column density may be two orders of magnitude lower than previous estimates. We show that the Hα luminosity decline is similar to other SNe with CSM interaction and demonstrate how our infrared photometry is evidence for newly formed, collisionally heated dust. We create a model for PTF11kx's late-time CSM interaction and find that X-ray reprocessing by photoionization and recombination cannot reproduce the observed Hα luminosity, suggesting that the X-rays are thermalized and that Hα radiates from collisional excitation. In conclusion, we discuss the implications of our results regarding the progenitor scenario and the geometric properties of the CSM for the PTF11kx system.« less

Comparison of stapedotomy minus prosthesis, circumferential stapes mobilization, and small fenestra stapedotomy for stapes fixation.

PubMed

Acar, Gül Ozbilen; Kivekäs, Ilkka; Hanna, Bassem M; Huang, Lin; Gopen, Quinton; Poe, Dennis S

2014-04-01

To compare the outcomes of 3 surgical techniques for primary stapes fixation: stapedotomy minus prosthesis (STAMP), circumferential stapes mobilization (CSM), and small fenestra stapedotomy (SFS). Retrospective review of 277 primary cases operated for stapes fixation from 1997 to 2007. Tertiary academic center. Consecutive adult and pediatric cases operated for conductive hearing loss because of stapes fixation. STAMP was performed for otosclerosis limited to the anterior footplate, CSM was conducted for congenital stapes fixation, SFS was performed for more extensive otosclerosis or anatomic contraindications to STAMP/CSM. Pure-tone audiometry was performed preoperatively and postoperatively (3-6 wk) and the most recent long-term results (≥ 12 mo). Ninety-nine ears in 90 patients had audiologic follow-up data over 12 months. Sixty-seven ears (68%) underwent SFS, 16 (16%) STAMP, and 16 (16%) CSM. There was significant improvement in average air conduction (AC) thresholds and air-bone gap (ABG) for all techniques. Mean ABG for SFS closed from 29 to 7.1 dB (SD, 6.0), for STAMP from 29 to 3.8 dB (SD, 5.8 dB), and for CSM from 34 to 20 dB (SD, 8.2 dB). AC results were better in the STAMP than in the SFS group, especially in high frequencies. Bone conduction improvements were seen in all groups, highest in STAMP (4.3 dB) and CSM (3.8 dB) groups, but the differences between groups were not statistically significant. Satisfactory hearing results were achieved with all the techniques, and STAMP showed better hearing outcomes, especially in high frequencies. CSM is a good option for children and patients in whom it is desirable to avoid a footplate fenestration or prosthesis. CSM and STAMP had significantly higher rates of revision for refixation than SFS.

PTF11kx: A Type Ia Supernova with Hydrogen Emission Persisting after 3.5 Years

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graham, M. L.; Harris, C. E.; Fox, O. D.

The optical transient PTF11kx exhibited both the characteristic spectral features of Type Ia supernovae (SNe Ia) and the signature of ejecta interacting with circumstellar material (CSM) containing hydrogen, indicating the presence of a nondegenerate companion. In this paper, we present an optical spectrum at 1342 days after peak from Keck Observatory, in which the broad component of Hα emission persists with a similar profile as in early-time observations. We also present Spitzer IRAC detections obtained 1237 and 1818 days after peak, and an upper limit from Hubble Space Telescope ultraviolet imaging at 2133 days. We interpret our late-time observations inmore » the context of published results—and reinterpret the early-time observations—in order to constrain the CSM's physical parameters and to compare to theoretical predictions for recurrent-nova systems. We find that the CSM's radial extent may be several times the distance between the star and the CSM's inner edge, and that the CSM column density may be two orders of magnitude lower than previous estimates. We show that the Hα luminosity decline is similar to other SNe with CSM interaction and demonstrate how our infrared photometry is evidence for newly formed, collisionally heated dust. We create a model for PTF11kx's late-time CSM interaction and find that X-ray reprocessing by photoionization and recombination cannot reproduce the observed Hα luminosity, suggesting that the X-rays are thermalized and that Hα radiates from collisional excitation. In conclusion, we discuss the implications of our results regarding the progenitor scenario and the geometric properties of the CSM for the PTF11kx system.« less

Advances in MR imaging for cervical spondylotic myelopathy.

PubMed

Ellingson, Benjamin M; Salamon, Noriko; Holly, Langston T

2015-04-01

To outline the pathogenesis of cervical spondylotic myelopathy (CSM), the correlative abnormalities observed on standard magnetic resonance imaging (MRI), the biological implications and current status of diffusion tensor imaging (DTI), and MR spectroscopy (MRS) as clinical tools, and future directions of MR technology in the management of CSM patients. A systematic review of the pathogenesis and current state-of-the-art in MR imaging technology for CSM was performed. CSM is caused by progressive, degenerative, vertebral column abnormalities that result in spinal cord damage related to both primary mechanical and secondary biological injuries. The T2 signal change on conventional MRI is most commonly associated with neurological deficits, but tends not to be a sensitive predictor of recovery of function. DTI and MRS show altered microstructure and biochemistry that reflect patient-specific pathogenesis. Advanced imaging techniques, including DTI and MRS, show higher sensitivity to microstructural and biochemical changes within the cord, and may aid in management of CSM patients.

The structure and emerging trends of construction safety management research: a bibliometric review.

PubMed

Liang, Huakang; Zhang, Shoujian; Su, Yikun

2018-03-29

Recently, construction safety management (CSM) practices and systems have become important topics for stakeholders to take care of human resources. However, few studies have attempted to map the global research on CSM. A comprehensive bibliometric review was conducted in this study based on multiple methods. In total, 1172 CSM-related papers from the Web of Science Core Collection database were examined. The analyses focused on publication year, country-institute, publication source, author and research topics. The results indicated that the USA, China, Australia and the UK took leading positions in CSM research. Two branches of journals were identified, namely the branch of engineering science and that of safety science and social science. Additionally, seven themes together with 28 specific topics were detected to allow researchers to track the main structure and temporal evolution of CSM research. Finally, the main research trends and potential research directions were discussed to guide the future research.

Command module/service module reaction control subsystem assessment

NASA Technical Reports Server (NTRS)

Weary, D. P.

1971-01-01

Detailed review of component failure histories, qualification adequacy, manufacturing flow, checkout requirements and flow, ground support equipment interfaces, subsystem interface verification, protective devices, and component design did not reveal major weaknesses in the command service module (CSM) reaction control system (RCS). No changes to the CSM RCS were recommended. The assessment reaffirmed the adequacy of the CSM RCS for future Apollo missions.

A historical discourse analysis of the cancerous and non-cancerous body in secondary biology textbooks

NASA Astrophysics Data System (ADS)

Bowers, Neil Thomas

This dissertation applies the archeological concepts developed by Michel Foucault to a study of thirteen biology textbooks (1993-2004) in order to develop an understanding of 'purchased truths' concerning cancer. This study focuses on the construction of the health/illness dialogue concerning cancer within the textbooks and not the meaning that the individual makes from reading the text; as such this study concerns itself with social truths rather than the search for an individual awareness of names, dates, or places. This study investigates the practices that allow the creation of dialogues that are inserted into a biology textbook and looks at how discursive formations create the 'truth regime' from which the biology textbook is said to speak. Using the Foucaultian themes of 'event', 'emergence', 'enunciation', and 'exteriority' a new reading of topics concerning cancer emerge from biology textbooks. Cancer is a disease that will impact the lives of countless individuals but coverage devoted to the pathology of cancer in secondary biology textbooks is very limited and no study textbook devoted a whole chapter to the discussion of cancer. There is an identified reduction in the number of pages and depth of coverage devoted to cancer in the newer biology texts compared to the older texts. Humans are pictured more than plants or animals in presentations concerning cancer with emphasis being placed on the digitalization of human cells via the scanning electron microscope. When the whole body is presented it is seldom located within the technology of disease diagnosis and treatment but rather is posed for specific social control. Just as each digitized picture of the cancerous cell in the texts is used to create a story so too are the pictures of the whole body in action. Possible story lines offered by the publishing houses concerning the reaction of the body to cancer are shown to intermingle with risk factor analysis to project a sense of Foucaultian 'governmentality' based on assumed control and self regulation by the informed reader. In conclusion a procedure is suggested to further analyze additional textbooks concerning biological/educational issues that have been recast as social problems.

Apollo 17 Command/Service modules photographed from lunar module in orbit

NASA Image and Video Library

1972-12-14

AS17-145-22273 (7-19 Dec. 1972) --- In this view, taken from the Lunar Module (LM), the Command and Service Module (CSM) are seen preparing to rendezvous with the LM. Note the reflection of the lunar surface on the CSM. The CSM, is piloted by Ronald E. Evans; while astronauts Eugene A. Cernan, commander; and Harrison W. Schmitt, lunar module pilot, are onboard the LM, following their extravehicular activities (EVA) on the moon's surface. While astronauts Cernan and Schmitt descended in the LM "Challenger" to explore the Taurus-Littrow region of the moon, astronaut Evans remained with the CSM "America" in lunar orbit.

Carbon contamination analysis and its effect on extreme ultra violet mask imaging performance using coherent scattering microscopy/in-situ accelerated contamination system.

PubMed

Jeong, Chang Young; Lee, Sangsul; Doh, Jong Gul; Lee, Jae Uk; Cha, Han-sun; Nichols, William T; Lee, Dong Gun; Kim, Seong Sue; Cho, Han Ku; Rah, Seung-yu; Ahn, Jinho

2011-07-01

The coherent scattering microscopy/in-situ accelerated contamination system (CSM/ICS) is a developmental metrology tool designed to analyze the impact of carbon contamination on the imaging performance. It was installed at 11B EUVL beam-line of the Pohang Accelerator Laboratory (PAL). Monochromatized 13.5 nm wavelength beam with Mo/Si multilayer mirrors and zirconium filters was used. The CSM/ICS is composed of the CSM for measuring imaging properties and the ICS for implementing acceleration of carbon contamination. The CSM has been proposed as an actinic inspection technique that records the coherent diffraction pattern from the EUV mask and reconstructs its aerial image using a phase retrieval algorithm. To improve the CSM measurement accuracy, optical and electrical noises of main chamber were minimized. The background noise level measured by CCD camera was approximately 8.5 counts (3 sigma) when the EUV beam was off. Actinic CD measurement repeatability was <1 A (3 sigma) at 17.5 nm line and space pattern. The influence of carbon contamination on the imaging properties can be analyzed by transferring EUV mask to CSM imaging center position after executing carbon contamination without a fine alignment system. We also installed photodiode and ellipsometry for in-situ reflectivity and thickness measurement. This paper describes optical design and system performance observed during the first phase of integration, including CSM imaging performance and carbon contamination analysis results.

Data-driven risk identification in phase III clinical trials using central statistical monitoring.

PubMed

Timmermans, Catherine; Venet, David; Burzykowski, Tomasz

2016-02-01

Our interest lies in quality control for clinical trials, in the context of risk-based monitoring (RBM). We specifically study the use of central statistical monitoring (CSM) to support RBM. Under an RBM paradigm, we claim that CSM has a key role to play in identifying the "risks to the most critical data elements and processes" that will drive targeted oversight. In order to support this claim, we first see how to characterize the risks that may affect clinical trials. We then discuss how CSM can be understood as a tool for providing a set of data-driven key risk indicators (KRIs), which help to organize adaptive targeted monitoring. Several case studies are provided where issues in a clinical trial have been identified thanks to targeted investigation after the identification of a risk using CSM. Using CSM to build data-driven KRIs helps to identify different kinds of issues in clinical trials. This ability is directly linked with the exhaustiveness of the CSM approach and its flexibility in the definition of the risks that are searched for when identifying the KRIs. In practice, a CSM assessment of the clinical database seems essential to ensure data quality. The atypical data patterns found in some centers and variables are seen as KRIs under a RBM approach. Targeted monitoring or data management queries can be used to confirm whether the KRIs point to an actual issue or not.

A Place at the Table: Struggles for Equality in America. Teacher's Guide [and Student Text].

ERIC Educational Resources Information Center

Foster, Randy; Mapp, Amy; Fleming, Maria, Ed.

"A Place at the Table" contains a teacher's guide, a 40-minute videotape and a 144-page textbook. The kit is designed to help students explore the historical, ongoing struggle to realize the national ideals of freedom and equality. This teacher's guide comprises 13 lesson plans (one for the video and one for each of the 12 chapters in…

The Bible as a Resource for Teaching Cataloguing and Classification

ERIC Educational Resources Information Center

Unegbu, Vincent E.; Onuoha, Uloma D.

2013-01-01

The Bible is an important book that represents all courses that human beings engage in. Many professions use it as a textbook for their course, as are listed in this write up. In spite of the rich source of information embedded in it, library and information professions are yet to tap into it. The first two chapters of the Bible are a very good…

The "Shirt-Weenie": A Note on Teaching the Power of Face-Work and Tact in Social Interaction

ERIC Educational Resources Information Center

Sharp, Shane; Kordsmeier, Gregory T.

2008-01-01

Erving Goffman is one of the most important sociologists of the 20th century. Popular textbooks in sociology (e.g., Giddens, Duneier, and Appelbaum 2005; Macionis 2007) and social psychology (e.g., Aronson, Wilson, and Akert 2006; Cahill 2007; DeLamater and Myers 2007) devote large sections and entire chapters to Goffman's ideas concerning the…

Canadian Consensus on Female Nutrition: Adolescence, Reproduction, Menopause, and Beyond.

PubMed

O'Connor, Deborah L; Blake, Jennifer; Bell, Rhonda; Bowen, Angela; Callum, Jeannie; Fenton, Shanna; Gray-Donald, Katherine; Rossiter, Melissa; Adamo, Kristi; Brett, Kendra; Khatri, Nasreen; Robinson, Nicole; Tumback, Lindsay; Cheung, Anthony

2016-06-01

To provide health care professionals in Canada with the basic knowledge and tools to provide nutrition guidance to women through their lifecycle. Optimal nutrition through the female lifecycle was evaluated, with specific focus on adolescence, pre-conception, pregnancy, postpartum, menopause, and beyond. The guideline begins with an overview of guidance for all women, followed by chapters that examine the evidence and provide recommendations for the promotion of healthy nutrition and body weight at each life stage. Nutrients of special concern and other considerations unique to each life stage are discussed in each chapter. Published literature, governmental and health agency reports, clinical practice guidelines, grey literature, and textbook sources were used in supporting the recommendations made in this document. The quality of evidence was rated using the criteria described in the report of the Canadian Task Force on Preventive Health Care. CHAPTER 2: GENERAL FEMALE NUTRITION: Summary Statements Recommendations CHAPTER 3: ADOLESCENCE NUTRITION: Summary Statements Recommendations CHAPTER 4: PRE-CONCEPTUAL NUTRITION: Summary Statement Recommendations CHAPTER 5: NUTRITION IN PREGNANCY: Summary Statements Recommendations CHAPTER 6: POSTPARTUM NUTRITION AND LACTATION: Summary Statements Recommendations CHAPTER 7: NUTRITION DURING MENOPAUSE AND BEYOND: Summary Statement Recommendations. Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.

An innovative textbook: design and implementation.

PubMed

Ortega, Rafael; Akhtar-Khavari, Vafa; Barash, Paul; Sharar, Sam; Stock, M Christine

2017-12-01

The 'flipped classroom' instructional strategy has gained much momentum in educational discourse, yet no single educational offering exists in postgraduate medical education (PME) to systematically replace the lecture element of didactic sessions. This article describes the design and implementation of Clinical Anesthesia Fundamentals, the first known textbook in PME addressing this gap in resources through the integration of full-length interactive multimedia-enhanced video lectures. The 'flipped classroom' instructional strategy has gained much momentum in educational discourse INNOVATION: The textbook was developed in alignment with the content outline for the specialty provided by the American Board of Anesthesiology. Its accompanying video lectures, produced at the Media Lab in the Department of Anesthesiology at Boston University Medical Center (BUMC), cover the topics in each chapter of the textbook and include review questions featuring explanatory feedback. Following a 5-month trial period at the BUMC Anesthesiology Residency Program, the complete resident class (25 of 25; 100%) participated in an anonymous, Institutional Review Board (IRB) -approved, five-point Likert-type scale survey assessing an underlying variable of preference for the use of multimedia learning tools. Survey results suggest that residents favour technology-enhanced learning environments in which textbooks are coupled with interactive multimedia, and the 'flipped classroom' approach is employed. Although the development of digital videos requires time and financial investment, the improved accessibility and uniform delivery of didactic content are two positive outcomes. This textbook provides an example for educators wishing to learn how to capitalise on advances in technology to further enhance learning and accessibility. Further studies could address the impact of this approach on the academic performance of residents. © 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

A Guide for Understanding Health Education and Promotion Programs.

PubMed

Kim, Richard W; Nahar, Vinayak K

2018-03-01

Planning, Implementing & Evaluating Health Promotion Programs: A Primer is a versatile and comprehensive resource on the theoretical and practical underpinnings of successful health promotion programs. The requirements for effective health promotion program development are presented with frequent use of practical planning examples, pedagogical devices, and expert rationale. Ideal for undergraduate and graduate students in health education, promotion, and planning courses, this 15-chapter textbook is organized in a manner that specifically addresses the responsibilities and competencies required of health education specialists as published in the Health Education Specialist Practice Analysis of 2015. The authors of this textbook are leaders in the field and provide readers with the skills necessary to carry out the full process of health promotion program execution, while also offering direct preparation for CHES and MCHES licensing exams.

International textbook of family medicine: the application of EURACT teaching agenda.

PubMed

Švab, Igor; Katić, Milica

2014-01-01

The paper describes experiences in the development of an international textbook of family medicine. The process of its development has started in Slovenia, where the Slovenian authors have written a textbook, adhering strictly to the European definition of family medicine and its core competencies. The format and the approach were also adopted by Croatian authors, who have used most of the material from the Slovenian book, but have modified some of the chapters according to the situation in the country and have added some of their own. This activity has created an opportunity for a truly international collaboration in the area of education of family medicine, with a creation of an international consortium, which would be responsible for the core content of the book and local adaptations of the book according to the specificities and needs of different countries. This innovative approach in the development of teaching material may be interesting for a variety of smaller countries in Europe and worldwide. Copyright © 2014 by Academy of Sciences and Arts of Bosnia and Herzegovina.

Automated Text Markup for Information Retrieval from an Electronic Textbook of Infectious Disease

PubMed Central

Berrios, Daniel C.; Kehler, Andrew; Kim, David K.; Yu, Victor L.; Fagan, Lawrence M.

1998-01-01

The information needs of practicing clinicians frequently require textbook or journal searches. Making these sources available in electronic form improves the speed of these searches, but precision (i.e., the fraction of relevant to total documents retrieved) remains low. Improving the traditional keyword search by transforming search terms into canonical concepts does not improve search precision greatly. Kim et al. have designed and built a prototype system (MYCIN II) for computer-based information retrieval from a forthcoming electronic textbook of infectious disease. The system requires manual indexing by experts in the form of complex text markup. However, this mark-up process is time consuming (about 3 person-hours to generate, review, and transcribe the index for each of 218 chapters). We have designed and implemented a system to semiautomate the markup process. The system, information extraction for semiautomated indexing of documents (ISAID), uses query models and existing information-extraction tools to provide support for any user, including the author of the source material, to mark up tertiary information sources quickly and accurately.

Structure of the CRISPR Interference Complex CSM Reveals Key Similarities with Cascade

PubMed Central

Rouillon, Christophe; Zhou, Min; Zhang, Jing; Politis, Argyris; Beilsten-Edmands, Victoria; Cannone, Giuseppe; Graham, Shirley; Robinson, Carol V.; Spagnolo, Laura; White, Malcolm F.

2013-01-01

Summary The Clustered Regularly Interspaced Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes. Interference complexes encoded by CRISPR-associated (cas) genes utilize small RNAs for homology-directed detection and subsequent degradation of invading genetic elements, and they have been classified into three main types (I–III). Type III complexes share the Cas10 subunit but are subclassifed as type IIIA (CSM) and type IIIB (CMR), depending on their specificity for DNA or RNA targets, respectively. The role of CSM in limiting the spread of conjugative plasmids in Staphylococcus epidermidis was first described in 2008. Here, we report a detailed investigation of the composition and structure of the CSM complex from the archaeon Sulfolobus solfataricus, using a combination of electron microscopy, mass spectrometry, and deep sequencing. This reveals a three-dimensional model for the CSM complex that includes a helical component strikingly reminiscent of the backbone structure of the type I (Cascade) family. PMID:24119402

Characteristics of combustion flame sprayed nickel aluminum using a Coanda Assisted Spray Manipulation collar for off-normal deposits

NASA Astrophysics Data System (ADS)

Archibald, Reid S.

A novel flame spray collar called the Coanda Assisted Spray Manipulation collar (CSM) has been tested for use on the Sulzer Metco 5P II combustion flame spray gun. A comparison study of the stock nozzle and the CSM has been performed by evaluating the porosity, surface roughness, microhardness, tensile strength and microscopy of normal and off-normal sprayed NiAl deposits. The use of the CSM collar resulted in the need to position the sprayed coupons closer to the gun, which in turn affected the particle impact energy and particle temperatures of the NiAl powder. For the CSM, porosities had a larger scatterband, surface roughness was comparably the same, microhardness was lower, and tensile strength was higher. The microscopy analysis revealed a greater presence of unmelted particles and steeper intersplat boundaries for the CSM. For both processes, the porosity and surface roughness increased and the microhardness decreased as the spray angle decreased.

NOTE: A Monte Carlo study of dose rate distribution around the specially asymmetric CSM3-a 137Cs source

NASA Astrophysics Data System (ADS)

Pérez-Calatayud, J.; Lliso, F.; Ballester, F.; Serrano, M. A.; Lluch, J. L.; Limami, Y.; Puchades, V.; Casal, E.

2001-07-01

The CSM3 137Cs type stainless-steel encapsulated source is widely used in manually afterloaded low dose rate brachytherapy. A specially asymmetric source, CSM3-a, has been designed by CIS Bio International (France) substituting the eyelet side seed with an inactive material in the CSM3 source. This modification has been done in order to allow a uniform dose level over the upper vaginal surface when this `linear' source is inserted at the top of the dome vaginal applicators. In this study the Monte Carlo GEANT3 simulation code, incorporating the source geometry in detail, was used to investigate the dosimetric characteristics of this special CSM3-a 137Cs brachytherapy source. The absolute dose rate distribution in water around this source was calculated and is presented in the form of an along-away table. Comparison of Sievert integral type calculations with Monte Carlo results are discussed.

The computational structural mechanics testbed procedures manual

NASA Technical Reports Server (NTRS)

Stewart, Caroline B. (Compiler)

1991-01-01

The purpose of this manual is to document the standard high level command language procedures of the Computational Structural Mechanics (CSM) Testbed software system. A description of each procedure including its function, commands, data interface, and use is presented. This manual is designed to assist users in defining and using command procedures to perform structural analysis in the CSM Testbed User's Manual and the CSM Testbed Data Library Description.

Force Plate Gait Analysis in Doberman Pinschers with and without Cervical Spondylomyelopathy

PubMed Central

Foss, K.; da Costa, R.C.; Rajala-Shultz, P.J.; Allen, M.J.

2014-01-01

Background The most accepted means of evaluating the response of a patient with cervical spondylomyelopathy (CSM) to treatment is subjective and based on the owner and clinician's perception of the gait. Objective To establish and compare kinetic parameters based on force plate gait analysis between normal and CSM-affected Dobermans. Animals Nineteen Doberman Pinschers: 10 clinically normal and 9 with CSM. Methods Force plate analysis was prospectively performed in all dogs. At least 4 runs of ipsilateral limbs were collected from each dog. Eight force platform parameters were evaluated, including peak vertical force (PVF) and peak vertical impulse (PVI), peak mediolateral force (PMLF) and peak mediolateral impulse, peak braking force and peak braking impulse, and peak propulsive force (PPF) and peak propulsive impulse. In addition, the coefficient of variation (CV) for each limb was calculated for each parameter. Data analysis was performed by a repeated measures approach. Results PMLF (P = .0062), PVI (P = .0225), and PPF (P = .0408) were found to be lower in CSM-affected dogs compared with normal dogs. Analysis by CV as the outcome indicated more variability in PVF in CSM-affected dogs (P = 0.0045). The largest difference in the CV of PVF was seen in the thoracic limbs of affected dogs when compared with the thoracic limbs of normal dogs (P = 0.0019). Conclusions and Clinical Importance The CV of PVF in all 4 limbs, especially the thoracic limbs, distinguished clinically normal Dobermans from those with CSM. Other kinetic parameters less reliably distinguished CSM-affected from clinically normal Dobermans. PMID:23278957

Effects of dietary cholesterol supplementation on growth and cholesterol metabolism of rainbow trout (Oncorhynchus mykiss) fed diets with cottonseed meal or rapeseed meal.

PubMed

Deng, Junming; Zhang, Xi; Long, Xiaowen; Tao, Linli; Wang, Zhen; Niu, Guoyi; Kang, Bin

2014-12-01

This study was conducted to evaluate the effects of cholesterol on growth and cholesterol metabolism of rainbow trout (Oncorhynchus mykiss) fed diets with cottonseed meal (CSM) or rapeseed meal (RSM). Four experimental diets were formulated to contain 550 g kg(-1) CSM or 450 g kg(-1) RSM with or without 9 g kg(-1) supplemental cholesterol. Growth rate and feed utilization efficiency of fish fed diets with 450 g kg(-1) RSM were inferior to fish fed diets with 550 g kg(-1) CSM regardless of cholesterol level. Dietary cholesterol supplementation increased the growth rate of fish fed diets with RSM, and growth rate and feed utilization efficiency of fish fed diets with CSM. Similarly, dietary cholesterol supplementation increased the plasma total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triiodothyronine levels, but decreased the plasma triglycerides and cortisol levels of fish fed diets with RSM or CSM. In addition, supplemental cholesterol increased the free cholesterol and TC levels in intestinal contents, but decreased the hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase activity of fish fed diets with RSM or CSM. These results indicate that 9 g kg(-1) cholesterol supplementation seems to improve the growth of rainbow trout fed diets with CSM or RSM, and the growth-promoting action may be related to the alleviation of the negative effects caused by antinutritional factors and/or make up for the deficiency of endogenous cholesterol in rainbow trout.

Bundled payment reimbursement for anterior and posterior approaches for cervical spondylotic myelopathy: an analysis of private payer and Medicare databases.

PubMed

Virk, Sohrab S; Phillips, Frank M; Khan, Safdar N

2018-03-01

OBJECTIVE Cervical spondylotic myelopathy (CSM) is a progressive spinal condition that often requires surgery. Studies have shown the clinical equivalency of anterior versus posterior approaches for CSM surgery. The purpose of this study was to determine the amount and type of resources used for anterior and posterior surgical treatment of CSM by using large national databases of clinical and financial information from patients. METHODS This study consists of 2 large cohorts of patients who underwent either an anterior or posterior approach for treatment of CSM. These patients were selected from the Medicare 5% National Sample Administrative Database (SAF5) and the Humana orthopedic database (HORTHO), which is a database of patients with private payer health insurance. The outcome measures were the cost of a 90-day episode of care, as well as a breakdown of the cost components for each surgical procedure between 2005 and 2014. RESULTS A total of 16,444 patients were included in this analysis. In HORTHO, there were 10,332 and 1556 patients treated with an anterior or posterior approach for CSM, respectively. In SAF5, there were 3851 and 705 patients who were treated by an anterior or posterior approach for CSM, respectively. The mean ± SD reimbursements for anterior and posterior approaches in the HORTHO database were $20,863 ± $2014 and $23,813 ± $4258, respectively (p = 0.048). The mean ± SD reimbursements for anterior and posterior approaches in the SAF5 database were $18,219 ± $1053 and $25,598 ± $1686, respectively (p < 0.0001). There were also significantly higher reimbursements for a rehabilitation/skilled nursing facility and hospital/inpatient care for patients who underwent a posterior approach in both the private payer and Medicare databases. In all cohorts in this study, the hospital-related reimbursement was more than double the surgeon-related reimbursement. CONCLUSIONS This study provides resource utilization information for a 90-day episode of care for both anterior and posterior approaches for CSM surgery. There is a statistically significant higher resource utilization for patients undergoing the posterior approach for CSM, which is consistent with the literature. Understanding the reimbursement patterns for anterior versus posterior approaches for CSM will help providers design a bundled payment for patients requiring surgery for CSM, and this study suggests that a subset of patients who require the posterior approach for treatment also require greater resources. The data also suggest that hospital-related reimbursement is the major driver of payments.

Current Military Perinatal Mental Health Treatment Models

DTIC Science & Technology

2016-03-03

Form 3039, 20 131018 Page 3 of 3 CHAPTER 12 PRENATAL ASSESSMENT AND INTERVENTION Pregnancy is a marvelment that researchers struggle to understand...The physiological and psychological changes brought about with pregnancy are so complex that in the 6th ed ition of the Williams obstetrical...textbook (Shears & Williams, 1928) it was stated that " pregnancy begins with a striking and wonderful phenomenon which in the present state of our

Missile aerodynamics

NASA Technical Reports Server (NTRS)

Nielsen, Jack N.

1988-01-01

The fundamental aerodynamics of slender bodies is examined in the reprint edition of an introductory textbook originally published in 1960. Chapters are devoted to the formulas commonly used in missile aerodynamics; slender-body theory at supersonic and subsonic speeds; vortices in viscid and inviscid flow; wing-body interference; downwash, sidewash, and the wake; wing-tail interference; aerodynamic controls; pressure foredrag, base drag, and skin friction; and stability derivatives. Diagrams, graphs, tables of terms and formulas are provided.

The Earliest Reference to ADHD in the Medical Literature? Melchior Adam Weikard's Description in 1775 of "Attention Deficit" (Mangel der Aufmerksamkeit, Attentio Volubilis)

ERIC Educational Resources Information Center

Barkley, Russell A.; Peters, Helmut

2012-01-01

Objective: The present article reports on the discovery and translation of a chapter in a 1775 medical textbook by the German physician, Melchior Adam Weikard, which describes attention disorders. This article is believed to be the earliest reference to the syndrome that today is known as attention deficit hyperactivity disorder, or ADHD. Method:…

Reprint Filing: A Profile-Based Solution

PubMed Central

Gass, David A.; Putnam, R. Wayne

1983-01-01

A reprint filing system based on practice profiles can give family physicians easy access to relevant medical information. The use of the ICHPPC classification and some supplemental categories provides a more practical coding mechanism than organ systems, textbook chapter titles or even Index Medicus subject headings. The system can be simply maintained, updated and improved, but users must regularly weed out unused information, and read widely to keep the reprints current. PMID:21283301

Use of CAD Geometry in MDO

NASA Technical Reports Server (NTRS)

Samareh, Jamshid A.

1996-01-01

The purpose of this paper is to discuss the use of Computer-Aided Design (CAD) geometry in a Multi-Disciplinary Design Optimization (MDO) environment. Two techniques are presented to facilitate the use of CAD geometry by different disciplines, such as Computational Fluid Dynamics (CFD) and Computational Structural Mechanics (CSM). One method is to transfer the load from a CFD grid to a CSM grid. The second method is to update the CAD geometry for CSM deflection.

Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows.

PubMed

Wang, A P; Zhang, J M; Meng, Y L; Deng, L Q; Lv, Y F; Li, C; Wang, J Q

2012-09-01

Free gossypol residues in tissues or milk from feeding whole cottonseed and cottonseed meal were measured for their effect on health of dairy cows and humans. Forty lactating cows were randomly assigned to 5 treatments in a 60-d experiment to investigate the effects of sources and dietary level of gossypol on plasma and milk gossypol concentrations in lactating cows. Five experimental diets had identical net energy for lactation and crude protein content on a dry matter (DM) basis. Soybean meal was the main protein ingredient used in the control diet. Cottonseed meal (CSM) or whole cottonseed (WCS) substituted for part of the soybean meal in the other 4 diets. Gossypol levels in the 5 diets were 0 (control), 91.15 mg/kg of DM in CSM1, 117.31mg/kg of DM in CSM2, 385.43 mg/kg of DM in WCS1, and 611.13 mg/kg in WCS2. Yields of 3.5% fat-corrected milk were significantly higher for cows in the WCS2 group; cows in the CSM1 and WCS1 groups showed no differences but both were numerically higher than the control and CSM2 groups. Milk protein concentration was lower for cows consuming WCS1 compared with the control group. Lactose concentration was lower for cows in the CSM2 group compared with the WCS2 group, but no differences were observed among other diets. Aspartate aminotransferase in serum was significantly higher for the WCS2 group compared with the control and WCS1 groups, but no difference was observed with the CSM1 and CSM2 groups. Concentrations of gossypol in plasma and milk of cows in the WCS1 and WCS2 groups were both higher than those of the other groups. No adverse effects were observed on cows fed diets containing 12.0% CSM, and no gossypol was found in plasma and milk. When WCS comprised 15% of the diet DM, yields of 3.5% fat-corrected milk were increased in cows and gossypol was detected in plasma and milk but not at harmful levels. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Evaluation of energy digestibility and prediction of digestible and metabolizable energy from chemical composition of different cottonseed meal sources fed to growing pigs.

PubMed

Li, J T; Li, D F; Zang, J J; Yang, W J; Zhang, W J; Zhang, L Y

2012-10-01

The present experiment was conducted to determine the digestible energy (DE), metabolizable energy (ME) content, and the apparent total tract digestibility (ATTD) of energy in growing pigs fed diets containing one of ten cottonseed meals (CSM) collected from different provinces of China and to develop in vitro prediction equations for DE and ME content from chemical composition of the CSM samples. Twelve growing barrows with an initial body weight of 35.2±1.7 kg were allotted to two 6×6 Latin square designs, with six barrows and six periods and six diets for each. A corn-dehulled soybean meal diet was used as the basal diet, and the other ten diets were formulated with corn, dehulled soybean meal and 19.20% CSM. The DE, ME and ATTD of gross energy among different CSM sources varied largely and ranged from 1,856 to 2,730 kcal/kg dry matter (DM), 1,778 to 2,534 kcal/kg DM, and 42.08 to 60.47%, respectively. Several chemical parameters were identified to predict the DE and ME values of CSM, and the accuracy of prediction models were also tested. The best fit equations were: DE, kcal/kg DM = 670.14+31.12 CP+659.15 EE with R(2) = 0.82, RSD = 172.02, p<0.05; and ME, kcal/kg DM = 843.98+25.03 CP+673.97 EE with R(2) = 0.84, RSD = 144.79, p<0.05. These results indicate that DE, ME values and ATTD of gross energy varied substantially among different CSM sources, and that some prediction equations can be applied to predict DE and ME in CSM with an acceptable accuracy.

COMT Val158Met Polymorphism and Symptom Improvement Following a Cognitively-Focused Intervention for Irritable Bowel Syndrome

PubMed Central

Han, Claire J.; Kohen, Ruth; Jun, Sangeun; Jarrett, Monica E.; Cain, Kevin C.; Burr, Robert; Heitkemper, Margaret M.

2016-01-01

Background Our nurse-delivered Comprehensive Self-Management (CSM) program, a cognitive behavioral therapy intervention, is effective in reducing gastrointestinal and psychological distress symptoms in patients with irritable bowel syndrome (IBS). Findings from non-IBS studies indicate that the catechol-O-methyltransferase (COMT) Val158Met polymorphism may moderate the efficacy of cognitive behavioral therapy. It is unknown whether this COMT polymorphism is associated with symptom improvements in patients with IBS. Objective We tested whether this COMT Val158Met polymorphism influences the efficacy of our two-month CSM intervention. Methods We analyzed data from two published randomized controlled trials of CSM. The combined European-American sample included 149 women and 23 men with IBS (CSM, n =111; Usual Care [UC], n = 61). The primary outcomes were daily reports of abdominal pain, depression, anxiety, and feeling stressed measured three and six months after randomization. Secondary outcomes were additional daily symptoms, retrospective psychological distress, IBS quality of life, and cognitive beliefs about IBS. The interaction between COMT Val158Met polymorphism and treatment group (CSM vs. UC) in a generalized estimating equation model tested the main objective. Results At three months, participants with at least one Val allele benefited more from CSM than did those with the Met/Met genotype (p = .01 for anxiety and feeling stressed, and p < .16 for abdominal pain and depression). The moderating effect of genotype was weaker at six months. Discussion Persons with at least one Val allele may benefit more from CSM than those homozygous for the Met allele. Future studies with larger and more racially diverse samples are needed to confirm these findings. RCT Registration Parent studies were registered at ClinicalTrials.gov (NCT00167635 and NCT00907790). PMID:28252569

The Origin and Evolution of the Infrared Light Curve of SN2010jl

NASA Astrophysics Data System (ADS)

Dwek, Eli; Sarangi, Arkaprabha; Arendt, Richard; Fox, Ori; Kallman, Timothy; Kazanas, Demosthenes

2018-01-01

SN2010jl is a luminous core-collapse supernova (CCSN) of Type IIn that is surrounded by a dense circumstellar medium (CSM). The supernova (SN) luminosity vastly exceeds the available power from radiactive elements in the ejecta, and is powered by the interaction of the SN shock wave with the ambient medium. Upper limits on the UV and near-IR (NIR) emission from pre-explosion images of the region suggest that any progenitor star was hidden by pre-existing CSM dust. After day ~80, the SN spectrum shows the development of an IR excess above the extrapolated UVO emission arising from the shocked CSM. This IR component is attributed to thermal emission from dust.After day ~300, the light curve exhibits a rise in the NIR luminosity, concurrent with a steep decline at UVO wavelengths. Ruling out any possible contribution of SN-condensed dust to the IR light curve, we show that the early IR emission arises from the pre-existing CSM dust that survived the flash of radiation from the shock breakout. The late IR emission arises from newly-formed CSM dust that condensed in the cooling dust-free postshock gas of the advancing SN shock wave. Our analysis presents the first detailed modeling of dust formation in a cooling postshock environment, and provides important insights into the interaction of the SN shock wave with the CSM.

A ruler protein in a complex for antiviral defense determines the length of small interfering CRISPR RNAs.

PubMed

Hatoum-Aslan, Asma; Samai, Poulami; Maniv, Inbal; Jiang, Wenyan; Marraffini, Luciano A

2013-09-27

Small RNAs undergo maturation events that precisely determine the length and structure required for their function. CRISPRs (clustered regularly interspaced short palindromic repeats) encode small RNAs (crRNAs) that together with CRISPR-associated (cas) genes constitute a sequence-specific prokaryotic immune system for anti-viral and anti-plasmid defense. crRNAs are subject to multiple processing events during their biogenesis, and little is known about the mechanism of the final maturation step. We show that in the Staphylococcus epidermidis type III CRISPR-Cas system, mature crRNAs are measured in a Cas10·Csm ribonucleoprotein complex to yield discrete lengths that differ by 6-nucleotide increments. We looked for mutants that impact this crRNA size pattern and found that an alanine substitution of a conserved aspartate residue of Csm3 eliminates the 6-nucleotide increments in the length of crRNAs. In vitro, recombinant Csm3 binds RNA molecules at multiple sites, producing gel-shift patterns that suggest that each protein binds 6 nucleotides of substrate. In vivo, changes in the levels of Csm3 modulate the crRNA size distribution without disrupting the 6-nucleotide periodicity. Our data support a model in which multiple Csm3 molecules within the Cas10·Csm complex bind the crRNA with a 6-nucleotide periodicity to function as a ruler that measures the extent of crRNA maturation.

Apollo Guidance, Navigation, and Control (GNC) Hardware Overview

NASA Technical Reports Server (NTRS)

Interbartolo, Michael

2009-01-01

This viewgraph presentation reviews basic guidance, navigation and control (GNC) concepts, examines the Command and Service Module (CSM) and Lunar Module (LM) GNC organization and discusses the primary GNC and the CSM Stabilization and Control System (SCS), as well as other CSM-specific hardware. The LM Abort Guidance System (AGS), Control Electronics System (CES) and other LM-specific hardware are also addressed. Three subsystems exist on each vehicle: the computer subsystem (CSS), the inertial subsystem (ISS) and the optical subsystem (OSS). The CSS and ISS are almost identical between CSM and LM and each is designed to operate independently. CSM SCS hardware are highlighted, including translation control, rotation controls, gyro assemblies, a gyro display coupler and flight director attitude indicators. The LM AGS hardware are also highlighted and include the abort electronics assembly and the abort sensor assembly; while the LM CES hardware includes the attitude controller assembly, thrust/translation controller assemblies and the ascent engine arming assemble. Other common hardware including the Orbital Rate Display - Earth and Lunar (ORDEAL) and the Crewman Optical Alignment Sight (COAS), a docking aid, are also highlighted.

Detectors for Particle Radiation

NASA Astrophysics Data System (ADS)

Kleinknecht, Konrad

1999-01-01

This textbook provides a clear, concise and comprehensive review of the physical principles behind the devices used to detect charged particles and gamma rays, and the construction and performance of these many different types of detectors. Detectors for high-energy particles and radiation are used in many areas of science, especially particle physics and nuclear physics experiments, nuclear medicine, cosmic ray measurements, space sciences and geological exploration. This second edition includes all the latest developments in detector technology, including several new chapters covering micro-strip gas chambers, silicion strip detectors and CCDs, scintillating fibers, shower detectors using noble liquid gases, and compensating calorimeters for hadronic showers. This well-illustrated textbook contains examples from the many areas in science in which these detectors are used. It provides both a coursebook for students in physics, and a useful introduction for researchers in other fields.

Statistical Mechanics: A Concise Introduction for Chemists (by Benjamin Widom)

NASA Astrophysics Data System (ADS)

Kovac, Jeffrey

2002-11-01

This book should be in the hands of everyone who teaches undergraduate physical chemistry to provide a model for what can be taught in that course beyond the material contained in the standard textbooks. Graduate students and faculty who need to learn statistical mechanics can hardly find a better introduction. Even those who regularly teach a graduate course in this area will get some new ideas and inspiration from one of the leading practitioners of the field. For completeness, I must add that the book has one weakness. Although there are excellent in-chapter exercises with solutions, there are no end-of-chapter problems. Since there are many sources of good problems, this is a minor flaw in an otherwise wonderful book.

The Development of "Water Strider" Inquiry Learning Program for Improving Scientific Inquiry Learning Ability in the Chapter "The Little Creatures World" of the Korea Elementary School 5th Grade Science Textbook

ERIC Educational Resources Information Center

Kim, Dongryeul

2017-01-01

The purpose of this study was to develop a "Water strider" Inquiry Learning Program for improved inquiry learning, and to analyze the validity of the "Water strider." The Inquiry Learning Program's goal was to create an application for finding out an on-site applicability for the "Water strider" Inquiry Learning…

Emergency Victim Care. A Training Manual for Emergency Medical Technicians. Module 10. Injuries of the Eye, Ear, Nose, Abdomen, Central Nervous System and Genitalia. Burns and Environmental Injuries. Revised.

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Vocational Education.

This training manual for emergency medical technicians, one of 14 modules that comprise the Emergency Victim Care textbook, covers injuries of the eyes, ears, nose, abdomen, central nervous system (CNS), and genitalia; burns; and environmental injuries. Objectives stated for the two chapters are for the student to be able to describe procedures…

Perspectives in Fluid Dynamics

NASA Astrophysics Data System (ADS)

Batchelor, G. K.; Moffatt, H. K.; Worster, M. G.

2002-12-01

With applications ranging from modelling the environment to automotive design and physiology to astrophysics, conventional textbooks cannot hope to give students much information on what topics in fluid dynamics are currently being researched, or how to choose between them. This book rectifies matters. It consists of eleven chapters that introduce and review different branches of the subject for graduate-level courses, or for specialists seeking introductions to other areas. Hb ISBN (2001): 0-521-78061-6

CSM digital autopilot testing in support of ASTP experiments control requirements

NASA Technical Reports Server (NTRS)

Rue, D. L.

1975-01-01

Results are presented of CSM digital autopilot (DAP) testing. The testing was performed to demonstrate and evaluate control modes which are currently planned or could be considered for use in support of experiments on the ASTP mission. The testing was performed on the Lockheed Guidance, Navigation, and Control System Functional Simulator (GNCFS). This simulator, which was designed to test the Apollo and Skylab DAP control system, has been used extensively and is a proven tool for CSM DAP analysis.

Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks.

PubMed

Zeng, Q F; Yang, G L; Liu, G N; Wang, J P; Bai, S P; Ding, X M; Luo, Y H; Zhang, K Y

2014-08-01

The objective of this study was to determine the effects of gossypol from cottonseed meal (CSM) on growth performance, blood biochemical profiles, and liver histopathology of ducks. A total of 900 1-d-old ducks were randomly allocated to 5 treatments with 12 pens/treatment and 15 ducks/pen. The 5 experimental diets were formulated in such a way that 0% (a corn-soybean meal basal diet, diet 1), 25% (diet 2), 50% (diet 3), 75% (diet 4), and 100% (diet 5) of protein from soybean meal were replaced with that from CSM. All diets were formulated on a digestible amino acid basis. The experiment included 2 phases, the starter phase (1 to 3 wk) where the test diets contained graded levels of CSM and the growth phase (4 to 5 wk) where birds were fed a corn-soybean basal diet to examine the recovery of ducks after CSM withdrawal. Dietary CSM and gossypol linearly (P < 0.01) and quadratically (P < 0.01) decreased ADG and ADFI during d 1 to 14. The threshold of daily total gossypol (TG) and free gossypol (FG) intake based on ADG on d 1 to 7 and d 7 to 14 were 32.20 and 2.64 mg/d, and 92.12 and 9.62 mg/d, respectively. Serum alanine aminotransferase increased (P < 0.05) linearly with increasing level of gossypol in the diets (d 7), whereas aspartate aminotransferase increased (P < 0.05) linearly and quadratically (d 14). Serum albumin concentration decreased (P < 0.05) quadratically with increasing dietary CSM concentrations on d 21. The degree of damage to the liver increased markedly with increasing dietary CSM and gossypol content and the length of CSM and gossypol intake. On d 35, there was no difference on BW and blood profiles of ducks among all treatments. These results suggest that meat ducks' dietary TG and FG concentration should be lower than 928.9 and 77.2 mg/kg, respectively, during d 1 to 21 of age and that a 2-wk withdrawal of diets containing gossypol should be considered. © Poultry Science Association Inc.

Tract-Specific Volume Loss on 3T MRI in Patients with Cervical Spondylotic Myelopathy.

PubMed

Hopkins, Benjamin S; Weber, Kenneth A; Cloney, Michael Brendan; Paliwal, Monica; Parrish, Todd B; Smith, Zachary A

2018-04-11

Case-control. The aim of this study was to understand the role of high-resolution magnetic resonance (MR) in identifying regional cord volume loss in cervical spondylotic myelopathy (CSM). Preliminary studies suggest that compression of the ventral region of the cord may contribute disproportionately to CSM symptomology; however, tract-specific data are lacking in the CSM population. The current study is the first to use 3T MR imaging (MRI) images of CSM patients to determine specific volume loss at the level of detail of individual descending white matter tracts. Twelve patients with CSM and 14 age-matched were enrolled prospectively and underwent 3-Tesla MRI of the cervical spine. Using the high-resolution images of the spinal cord, straightening and alignment with a template was performed and specific spinal cord tract volumes were measured using Spinal Cord Tool-box version 3.0.7. Modified Japanese orthopedic association (mJOA) and Nurick disability scores were collected in a prospective manner and were analyzed in relation to descending spinal tract volumes. Having CSM was predicted by anterior/posterior diameter, eccentricity of the cord [odds ratio (OR) 0.000000621, P = 0.004], ventral reticulospinal tract volume (OR 1.167, P = 0.063), lateral corticospinal tract volume (OR 1.034, P = 0.046), rubrospinal tract volume (OR 1.072, P = 0.011), and ventrolateral reticulospinal tract volume (OR 1.474, P = 0.005) on single variable logistic regression. Single variable linear regression showed decreases in anterior/posterior spinal cord diameter (P = 0.022), ventral reticulospinal tract volumes (P = 0.007), and ventrolateral reticulospinal tract volumes (P = 0.017) to significantly predict worsening mJOA scores. Similarly, decreases in ventral reticulospinal tract volumes significantly predicted increasing Nurick scores (P = 0.039). High-resolution 3T MRI can detect tract-specific volume loss in descending spinal cord tracts in CSM patients. Anterior/posterior spinal cord diameter, ventral reticulospinal tract, ventrolateral reticulospinal tract, lateral corticospinal tract, and rubrospinal tract volume loss are associated with CSM symptoms. 2.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glucksberg, Nadia; Peters, Jay

The Conceptual Site Model (CSM) is a powerful tool for understanding the link between contamination sources, cleanup objectives, and ultimate site reuse. The CSM describes the site setting, geology, hydrogeology, potential sources, release mechanisms and migration pathways of contaminants. The CSM is needed to understand the extent of contamination and how receptors may be exposed to both radiological and chemical constituents. A key component of the CSM that is often overlooked concerns how the regulatory requirements drive remediation and how each has to be integrated into the CSM to ensure that all stakeholder requirements are understood and addressed. This papermore » describes how the use of the CSM helped reach closure and reuse at two facilities in Connecticut that are pursuing termination of their Nuclear Regulatory Commission (NRC) license. The two facilities are the Combustion Engineering Site, located in Windsor, Connecticut, (CE Windsor Site) and the Connecticut Yankee Atomic Power Company, located in Haddam Neck, Connecticut (CYAPCO). The closure of each of these facilities is regulated by four agencies: - Nuclear Regulatory Commission (NRC) - which requires cleanup levels for radionuclides to be protective of public health; - US Environmental Protection Agency (USEPA) - which requires cleanup levels for chemicals to be protective of public health and the environment; - Connecticut Department of Environmental Protection (CTDEP) Bureau of Air Management, Radiation Division - which requires cleanup levels for radionuclides to be protective of public health; and - Connecticut Department of Environmental Protection (CTDEP) Bureau of Water Protection and Land Reuse - which requires cleanup levels for chemicals to be protective of public health and the environment. Some of the radionuclides at the CE Windsor Site are also regulated under the Formerly Utilized Site Remedial Action Program (FUSRAP) under the Army Corps of Engineers. The remainder of this paper presents the similarities and differences between the CSMs for these two sites and how each site used the CSM to reach closure. Although each of these site have unique histories and physical features, the CSM approach was used to understand the geology, hydrogeology, migration and exposure pathways, and regulatory requirements to successfully characterize and plan closure of the sites. A summary of how these attributes affected site closure is provided.« less

NASA Workshop on Computational Structural Mechanics 1987, part 1

NASA Technical Reports Server (NTRS)

Sykes, Nancy P. (Editor)

1989-01-01

Topics in Computational Structural Mechanics (CSM) are reviewed. CSM parallel structural methods, a transputer finite element solver, architectures for multiprocessor computers, and parallel eigenvalue extraction are among the topics discussed.

Cervical Spondylotic Myelopathy (CSM)

MedlinePlus

... of CSM occur over time. They can include: neck pain or stiffness arm pain numbness in your hands ... Health, Men, Seniors, WomenTags: adult, elderly, Neck Disorders, neck pain, Neck Swelling, older adults, Rheumatologic, senior September 1, ...

The light-harvesting antenna of Chlorobium tepidum: interactions between the FMO protein and the major chlorosome protein CsmA studied by surface plasmon resonance.

PubMed

Pedersen, Marie Østergaard; Borch, Jonas; Højrup, Peter; Cox, Raymond P; Miller, Mette

2006-09-01

Green sulfur bacteria possess two external light-harvesting antenna systems, the chlorosome and the FMO protein, which participate in a sequential energy transfer to the reaction centers embedded in the cytoplasmic membrane. However, little is known about the physical interaction between these two antenna systems. We have studied the interaction between the major chlorosome protein, CsmA, and the FMO protein in Chlorobium tepidum using surface plasmon resonance (SPR). Our results show an interaction between the FMO protein and an immobilized synthetic peptide corresponding to 17 amino acids at the C terminal of CsmA. This interaction is dependent on the presence of a motif comprising six amino acids that are highly conserved in all the currently available CsmA protein sequences.

Balance of Autonomic Nervous System Predicts Who Benefits from a Self-management Intervention Program for Irritable Bowel Syndrome.

PubMed

Jarrett, Monica E; Cain, Kevin C; Barney, Pamela G; Burr, Robert L; Naliboff, Bruce D; Shulman, Robert; Zia, Jasmine; Heitkemper, Margaret M

2016-01-31

To determine if potential biomarkers can be used to identify subgroups of people with irritable bowel syndrome (IBS) who will benefit the most or the least from a comprehensive self-management (CSM) intervention. In a two-armed randomized controlled trial a CSM (n = 46) was compared to a usual care (n = 46) group with follow-up at 3 and 6 months post randomization. Biomarkers obtained at baseline included heart rate variability, salivary cortisol, interleukin-10 produced by unstimulated peripheral blood mononuclear cells, and lactulose/mannitol ratio. Linear mixed models were used to test whether these biomarkers predicted improvements in the primary outcomes including daily abdominal pain, Gastrointestinal Symptom score and IBS-specific quality of life. The nurse-delivered 8-session CSM intervention is more effective than usual care in reducing abdominal pain, reducing Gastrointestinal Symptom score, and enhancing quality of life. Participants with lower nighttime high frequency heart rate variability (vagal modulation) and increased low frequency/high frequency ratio (sympathovagal balance) had less benefit from CSM on abdominal pain. Salivary cortisol, IL-10, and lactulose/mannitol ratio were not statistically significant in predicting CSM benefit. Baseline symptom severity interacts with treatment, namely the benefit of CSM is greater in those with higher baseline symptoms. Cognitively-focused therapies may be less effective in reducing abdominal pain in IBS patients with higher sympathetic tone. Whether this a centrally-mediated patient characteristic or related to heightened arousal remains to be determined.

A Ruler Protein in a Complex for Antiviral Defense Determines the Length of Small Interfering CRISPR RNAs

PubMed Central

Hatoum-Aslan, Asma; Samai, Poulami; Maniv, Inbal; Jiang, Wenyan; Marraffini, Luciano A.

2013-01-01

Small RNAs undergo maturation events that precisely determine the length and structure required for their function. CRISPRs (clustered regularly interspaced short palindromic repeats) encode small RNAs (crRNAs) that together with CRISPR-associated (cas) genes constitute a sequence-specific prokaryotic immune system for anti-viral and anti-plasmid defense. crRNAs are subject to multiple processing events during their biogenesis, and little is known about the mechanism of the final maturation step. We show that in the Staphylococcus epidermidis type III CRISPR-Cas system, mature crRNAs are measured in a Cas10·Csm ribonucleoprotein complex to yield discrete lengths that differ by 6-nucleotide increments. We looked for mutants that impact this crRNA size pattern and found that an alanine substitution of a conserved aspartate residue of Csm3 eliminates the 6-nucleotide increments in the length of crRNAs. In vitro, recombinant Csm3 binds RNA molecules at multiple sites, producing gel-shift patterns that suggest that each protein binds 6 nucleotides of substrate. In vivo, changes in the levels of Csm3 modulate the crRNA size distribution without disrupting the 6-nucleotide periodicity. Our data support a model in which multiple Csm3 molecules within the Cas10·Csm complex bind the crRNA with a 6-nucleotide periodicity to function as a ruler that measures the extent of crRNA maturation. PMID:23935102

Replacing cottonseed meal with ground Prosopis juliflora pods; effect on intake, weight gain and carcass parameters of Afar sheep fed pasture hay basal diet.

PubMed

Yasin, Mohammed; Animut, Getachew

2014-08-01

The experiment was conducted to determine the supplementary feeding value of ground Prosopis juliflora pod (Pjp) and cottonseed meal (CSM) and their mixtures on feed intake, body weight gain and carcass parameters of Afar sheep fed a basal diet of pasture hay. Twenty-five yearling fat-tailed Afar rams with mean initial live weight 17.24 ± 1.76 kg (mean ± SD) were used in a randomized complete block design. Animals were blocked on their initial body weight. The experiment was conducted for 12 weeks and carcass evaluation followed. Treatments were hay alone ad libitum (T 1) or with 300 g CSM (T 2), 300 g Pjp (T 5), 2:1 ratio (T 3) and 1:2 ratio of CSM : Pjp (T 4). The CP contents of the hay, CSM and Pjp were 10.5, 44.5 and 16.7 %, respectively. Hay DM intake was higher (P < 0.05) for non-supplemented and total DM intake was lower in non-supplemented. Average daily weight gain (ADG) was lower (P < 0.05) for T 1 compared to all supplemented treatments except T 5. Hot carcass weight and rib-eye muscle area also followed the same trend like that of ADG. Compared with feeding hay alone, supplementing with CSM or a mixture of CSM and Pjp appeared to be a better feeding strategy, biologically, for yearling Afar rams.

The Incredibly Long-Lived SN 2005ip

NASA Astrophysics Data System (ADS)

Fox, Ori

2016-10-01

Type IIn supernovae (SNe IIn) are defined by their relatively narrow spectral line features associated with a dense circumstellar medium (CSM) formed by the progenitor star. The nature of the progenitor and mass loss remains relatively unknown. Shock interaction with the dense CSM can often result in significant UV emission for several years post-explosion, thereby probing the CSM characteristics, progenitor mass loss history and, ultimately, the progenitor itself. The Type IIn SN 2005ip proves to be one of the most interesting and well-studied targets within this subclass. Compared to all other supernovae, SN 2005ip is the most luminous for its age. Now more than 11 years post-explosion, the SN has released >10^51 erg throughout its lifetime as the forward shock continues to collide with a dense CSM. Here we propose HST/STIS-MAMA UV observations of SN 2005ip to investigate the massive CSM. When accounting for the shock travel time, these observations will probe material lost from the progenitor more than 1000 years prior to the explosion. We already have a single HST/STIS spectrum of SN 2005ip from 2014, which was obtained while the shock was still within a higher mass regime. With just 5 orbits, a second spectrum will allow us to directly trace the evolution of the CSM and produce new constraints on the pre-SN mass-loss history. Coinciding with Cycle 24's UV Initiative, this program offers new insight regarding both the progenitor and explosion characteristics of the SN IIn subclass.

Teach Astronomy: An Online Resource for Introductory Astronomy Courses and Informal Learners

NASA Astrophysics Data System (ADS)

Austin, Carmen; Impey, C. D.; Hardegree-Ullman, K.; Patikkal, A.; Ganesan, N.

2013-01-01

Teach Astronomy (www.teachastronomy.com) is a new, free online resource—a teaching tool for non-science major astronomy courses and a reference guide for lifelong learners interested in the subject. Digital content available includes: a comprehensive introductory astronomy textbook by Chris Impey, Wikipedia astronomy articles, images from Astronomy Picture of the Day archives and AstroPix database, two to three minute topical video clips by Chris Impey, podcasts from 365 Days of Astronomy archives, and an RSS feed of astronomy news from Science Daily. Teach Astronomy features an original technology called the Wikimap to cluster, display, and navigate site search results. Motivation behind the development of Teach Astronomy includes steep increases in textbook prices, the rapid adoption by students and the public of digital resources, and the modern capabilities of digital technology. Recent additions to Teach Astronomy include: AstroPix images—from some of the most advanced observatories and complete with metadata, mobile device functionality, links to WikiSky where users can see the location of astronomical objects in the sky, and end of chapter textbook review questions. Next in line for development are assignments for classroom use. We present suggestions for utilizing the rich content and features of the web site.

COOPER, HERON, AND HEWARD'S APPLIED BEHAVIOR ANALYSIS (2ND ED.): CHECKERED FLAG FOR STUDENTS AND PROFESSORS, YELLOW FLAG FOR THE FIELD

PubMed Central

Friman, Patrick C

2010-01-01

At last, the field of applied behavior analysis has a beautifully crafted, true textbook that can proudly stand cover to cover and spine to spine beside any of the expensive, imposing, and ornately designed textbooks used by college instructors who teach courses in conventional areas of education or psychology. In this review, I fully laud this development, credit Cooper, Heron, and Heward for making it happen, argue that it signifies a checkered flag for students and professors, and recommend the book for classes in applied behavior analysis everywhere. Subsequently, I review its chapters, each of which could easily stand alone as publications in their own right. Finally, I supply a cautionary note, a yellow flag to accompany the well-earned checkered flag, by pointing out that, as is true with all general textbooks on applied behavior analysis, a major portion of the references involves research on persons who occupy only a tail of the normal distribution. To attain the mainstream role Skinner envisioned and most (if not all) behavior analysts desire, the field will have to increase its focus on persons who reside under the dome of that distribution.

BOOK REVIEW: The Odd Quantum

NASA Astrophysics Data System (ADS)

Reynolds, Helen

2000-03-01

The Odd Quantum is aiming to be odd. Falling between being a quantum mechanics textbook and a `popular' science book, it aims to convey something of the substance of quantum mechanics without being overly technical or professional. It does not shy away from the mathematics of the subject or resort solely to analogy and metaphor, as so often is the case. Books aimed at the lay reader tend to take on a particular aspect of quantum mechanics, for example, wave-particle duality, and can do little more than hint at the complexity of the subject. This book is more than a textbook on quantum mechanics; it gives the reader a comprehensive account of history and an appreciation of the nature of quantum mechanics. The introductory chapters deal with the earlier part of the century and the thinking of that time. The approach is familiar, as are the stories that Treiman tells, but he also manages to convey the speed with which ideas changed and the excitement this brought to the physics community. Classical ideas of force and energy are dealt with succinctly but with sufficient depth to set up the reader for what is to come; Maxwell's equations and a brief glimpse at relativity are included. This is followed by a brief description of what the author terms the `old' quantum mechanics, in effect a highly readable tour around black body radiation and spectroscopy and the models of the atom that emerged from them. The `new' quantum mechanics begins about a third of the way through the book, and in a chapter entitled `Foundations' starts gently but rapidly moves into a detailed mathematical treatment. This section, of necessity, relapses into the style of a textbook and covers a lot of ground quickly. It is at this point that the non-specialist popular science readers for whom Treiman has written this book may become a little bemused. Concepts such as non-degeneracy and operators come thick and fast. It is difficult to imagine an educated non-physicist with little mathematical ability keeping track of the equations and their meaning. However, the text continues to be accessible and moves swiftly from `quantum classics' such as the harmonic oscillator to electrical conductivity and the collapse of stars. Reassuringly, Treiman takes time out to ask `What's going on?' where he considers the question of how probabilities get converted into `facts' when things are measured. His own fascination with the subject comes through as he considers the different interpretations of quantum mechanics. The chapter on `building blocks' starts in 1932 when ` ... it could seem that all the basic building blocks of the whole world were at last in hand'. Swiftly and succinctly it moves through to the standard model, acknowledging that a closer look would ` ... quickly carry us far afield into highly technical thickets'. The final chapter tackles the more difficult subject of quantum field theory. This is a very swift journey through quantum electrodynamics and quantum chromodynamics. It is the final summary that stands out, however. The author reminds us what to marvel about: the miracles of quantum theory that are ` ... outrageous to common sense and intuition'. This is a useful book for any science department. It will be of particular use to those of us who studied the subject some time ago and who need to refresh their memories, for example teachers of A-level physics. The asides about `what is going on' and the history that is included make it a `book' rather than a `textbook'. First-year undergraduates, or just possibly motivated and mathematically able A-level students, would also benefit. Beware, however. The mathematics is not trivial and you would arguably need to have met it before in order to cope. Although the book occasionally relapses into textbook style you are left with a sense of the wonder of the subject and an appreciation of the beauty of the mathematics that underpins it.

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

PubMed Central

2015-01-01

Drug development has a high attrition rate, with poor pharmacokinetic and safety properties a significant hurdle. Computational approaches may help minimize these risks. We have developed a novel approach (pkCSM) which uses graph-based signatures to develop predictive models of central ADMET properties for drug development. pkCSM performs as well or better than current methods. A freely accessible web server (http://structure.bioc.cam.ac.uk/pkcsm), which retains no information submitted to it, provides an integrated platform to rapidly evaluate pharmacokinetic and toxicity properties. PMID:25860834

Altimeter Processing Tools for Analyzing Mesoscale Ocean Features

DTIC Science & Technology

1990-09-01

However, since the programs are modular, users can easily use their own orbit and geoid corrections to study basin scale problems. We left programs that...g..repeat c*/c*.a002c > a002cs-m or %g.repeat c???/c???.a002c > a002cs-m The file aOO2cs.m contains the following information in tab delimited ...information in tab delimited columns: The sea surface height residual files are similar to those created by g.repeat. except that fi(z ,t) is the original

Thermal structure analyses for CSM testbed (COMET)

NASA Technical Reports Server (NTRS)

Xue, David Y.; Mei, Chuh

1994-01-01

This document is the final report for the project entitled 'Thermal Structure Analyses for CSM Testbed (COMET),' for the period of May 16, 1992 - August 15, 1994. The project was focused on the investigation and development of finite element analysis capability of the computational structural mechanics (CSM) testbed (COMET) software system in the field of thermal structural responses. The stages of this project consisted of investigating present capabilities, developing new functions, analysis demonstrations, and research topics. The appendices of this report list the detailed documents of major accomplishments and demonstration runstreams for future references.

BIOCONAID System (Bionic Control of Acceleration Induced Dimming).

DTIC Science & Technology

1981-07-01

Howard, P. , "The Physiology of Positive Acceleration," Chapter 23 in A Textbook of Aviation Physiology, Edited by J. A. Gilles, Pergamon Press...of the Carotid Sinus Baroreceptor Process in a Dog ," IEEE Trans. Biomed. Engineering, BME , Vol. 22, No. 3, pp. 502-507, 1975. 16. Leverett, S. D...Electromyogram, ’ IEEE Transactions on Biomedical Engineering. Vol. BME -24, No. 5, pp. 417-424, 1977. 26. Stoll, Alice M., "Human Tolerance to Positive G as

Benford’s Law: Textbook Exercises and Multiple-Choice Testbanks

PubMed Central

Slepkov, Aaron D.; Ironside, Kevin B.; DiBattista, David

2015-01-01

Benford’s Law describes the finding that the distribution of leading (or leftmost) digits of innumerable datasets follows a well-defined logarithmic trend, rather than an intuitive uniformity. In practice this means that the most common leading digit is 1, with an expected frequency of 30.1%, and the least common is 9, with an expected frequency of 4.6%. Currently, the most common application of Benford’s Law is in detecting number invention and tampering such as found in accounting-, tax-, and voter-fraud. We demonstrate that answers to end-of-chapter exercises in physics and chemistry textbooks conform to Benford’s Law. Subsequently, we investigate whether this fact can be used to gain advantage over random guessing in multiple-choice tests, and find that while testbank answers in introductory physics closely conform to Benford’s Law, the testbank is nonetheless secure against such a Benford’s attack for banal reasons. PMID:25689468

Quantitative Modeling of Earth Surface Processes

NASA Astrophysics Data System (ADS)

Pelletier, Jon D.

This textbook describes some of the most effective and straightforward quantitative techniques for modeling Earth surface processes. By emphasizing a core set of equations and solution techniques, the book presents state-of-the-art models currently employed in Earth surface process research, as well as a set of simple but practical research tools. Detailed case studies demonstrate application of the methods to a wide variety of processes including hillslope, fluvial, aeolian, glacial, tectonic, and climatic systems. Exercises at the end of each chapter begin with simple calculations and then progress to more sophisticated problems that require computer programming. All the necessary computer codes are available online at www.cambridge.org/9780521855976. Assuming some knowledge of calculus and basic programming experience, this quantitative textbook is designed for advanced geomorphology courses and as a reference book for professional researchers in Earth and planetary science looking for a quantitative approach to Earth surface processes.

Benford's Law: textbook exercises and multiple-choice testbanks.

PubMed

Slepkov, Aaron D; Ironside, Kevin B; DiBattista, David

2015-01-01

Benford's Law describes the finding that the distribution of leading (or leftmost) digits of innumerable datasets follows a well-defined logarithmic trend, rather than an intuitive uniformity. In practice this means that the most common leading digit is 1, with an expected frequency of 30.1%, and the least common is 9, with an expected frequency of 4.6%. Currently, the most common application of Benford's Law is in detecting number invention and tampering such as found in accounting-, tax-, and voter-fraud. We demonstrate that answers to end-of-chapter exercises in physics and chemistry textbooks conform to Benford's Law. Subsequently, we investigate whether this fact can be used to gain advantage over random guessing in multiple-choice tests, and find that while testbank answers in introductory physics closely conform to Benford's Law, the testbank is nonetheless secure against such a Benford's attack for banal reasons.

X-ray Emission from Supernovae in Dense Circumstellar Matter Environments: a Search for Collisionless Shocks

NASA Technical Reports Server (NTRS)

Ofek, E. O.; Fox, D.; Cenko, Stephen B.; Sullivan, M; Gnat, O.; Frail, D. A.; Horesh, A.; Corsi, A.; Quimby, R. M.; Gehrels, N.;

Intervertebral disk width in dogs with and without clinical signs of disk associated cervical spondylomyelopathy

PubMed Central

2012-01-01

Background Disk-associated cervical spondylomyelopathy (DA-CSM) is a multifactorial neurological disorder in which progressive caudal cervical spinal cord compression is mainly caused by one or more intervertebral disk protrusions. The Doberman pinscher breed seems predisposed for this condition. The underlying cause and pathophysiology of DA-CSM are currently unknown. Recently, wider intervertebral disks have been put forward as a risk factor for development of clinically relevant DA-CSM. However, little is known about other factors affecting intervertebral disk width. Therefore the aim of this study was to assess the association between intervertebral disk width, measured on magnetic resonance imaging (MRI), and clinical status, age, gender and intervertebral disk location in dogs with and without clinical signs of DA-CSM. Methods Doberman pinschers with clinical signs of DA-CSM (N=17),clinically normal Doberman pinschers (N=20), and clinically normal English Foxhounds (N=17), underwent MRI of the cervical vertebral column. On sagittal T2-weighted images, intervertebral disk width was measured from C2-C3 to C6-C7. Intra –and interobserver agreement were assessed on a subset of 20 of the 54 imaging studies. Results Intervertebral disk width was not significantly different between Doberman pinschers with clinical signs of DA-CSM, clinically normal Doberman pinschers or clinically normal English Foxhounds (p=0.43). Intervertebral disk width was positively associated with increasing age (p=0.029). Each monthly increase in age resulted in an increase of disk width by 0.0057mm. Intervertebral disk width was not significantly affected by gender (p=0.056), but was significantly influenced by intervertebral disk location (p <0.0001). The assessed measurements were associated with a good intra –and interobserver agreement. Conclusions The present study does not provide evidence that wider intervertebral disks are associated with clinical status in dogs with and without DA-CSM. Instead, it seems that cervical intervertebral disk width in dogs is positively associated with increase in age. PMID:22839697

Regional strategy tested in Caribbean.

PubMed

1984-01-01

Barbados, St. Vincent, and St. Lucia have joined forces in the world's 1st regional Contraceptive Social Marketing (CSM) effort -- the Caribbean CSM. The Barbados Family Planning Association (BFPS) is overseeing the operation, which begins selling 2 contraceptive pills and a condom in early February. Costs and start-up times were shaved by adopting brand names and advertising materials from Jamaica's highly successful CSM project. Jamaica's popular "Panther" condom and "Perle" oral contraceptive (OC) are being used by the Caribbean CSM project. Perle's 9-year-old package has been redesigned and the Caribbean CSM project also is selling a 2nd, low-dose version called "Perle-LD." The products are manufactured in the US by Syntex as Noriday and Norminest, respectively. But the regional approach's financial gains also had a debit side, most notably a tripling of bureaucratic procedures. Part of project difficulties stem from differences among the 3 Caribbean countries. While sharing a common cultural heritage, St. Lucians speak a patois dialect in addition to the English prevalent on the other islands. The biggest hurdle was overcoming an economic disparity between Barbados and its less affluent neighbors, St. Vincent and St. Lucia. The CSM project decided to try a 2-tier product pricing strategy. In US currency, prices run $1.75 per cycle for both OCs on Barbados, but $1.26 on St. Vincent and St. Lucia. A Panther 3-pack costs 75 cents on Barbados and 42 cents on the othe 2 islands. The project is being promoted with generic family planning media advertisements. The project also has held physician orientation seminars on each island. The pilot program will be accompanied by retailer training seminars. In addition the project may introduce a spermicidal foaming tablet, once the US Food and Drug Administration approvs a new American-made product. The unique Caribbean CSM project may spread an idea as potent as the family planning message. Its success could transmit the regional concept worldwide, helping small nations to slow the rate of their population growth.

A Sandbox Environment for the CSM Standard and SPICE

NASA Astrophysics Data System (ADS)

Hare, T. M.; Laura, J. R.

2018-04-01

We present ongoing work USGS is undertaking to provide a programming environment for the Camera Sensor Model (CSM) standard and associated SPICE information. This allows for instrument testing and experimentation outside a given production area.

Contraceptive social marketing and community-based distribution systems in Colombia.

PubMed

Vernon, R; Ojeda, G; Townsend, M C

1988-01-01

Three operations research experiments were carried out in three provinces of Colombia to improve the cost-effectiveness of Profamilia's nonclinic-based programs. The experiments tested: (a) whether a contraceptive social marketing (CSM) strategy can replace a community-based distribution (CBD) program in a high contraceptive use area; (b) if wage incentives for salaried CBD instructors will increase contraceptive sales; and (c) whether a specially equipped information, education, and communication (IEC) team can replace a cadre of rural promoters to expand family planning coverage. All three strategies proved to be effective, but only the CSM system yielded a profit. Despite this, Profamilia discontinued its CSM program soon after the experiment was completed. Unexpected government controls regulating the price and sale of contraceptives in Colombia made the program unprofitable. As a result, family planning agencies are cautioned against replacing CBD programs with CSM. Instead, CBD programs might adopt a more commercial approach to become more efficient.

Sweet Chestnut (Castanea sativa Mill.) Bark Extract: Cardiovascular Activity and Myocyte Protection against Oxidative Damage

PubMed Central

Chiarini, Alberto; Micucci, Matteo; Ioan, Pierfranco; Fimognari, Carmela; Gallina Toschi, Tullia; Comandini, Patrizia; Hrelia, Silvana

2013-01-01

This work was aimed at evaluating the cardioprotective effects of Castanea sativa Mill. (CSM) bark extract characterized in its phenolic composition by HPLC-DAD-MS analysis. The study was performed using primary cultures of neonatal rat cardiomyocytes to investigate the antioxidant and cytoprotective effects of CSM bark extract and isolated guinea pig left and right atria, left papillary muscle, and aorta to evaluate its direct effect on cholinergic and adrenergic response. In cultured cardiomyocytes the CSM bark extract reduced intracellular reactive oxygen species formation and improved cell viability following oxidative stress in dose-dependent manner. Moreover, the extract decreased the contraction induced by noradrenaline (1 μM) in guinea pig aortic strips and induced transient negative chronotropic and positive inotropic effects without involvement of cholinergic or adrenergic receptors in the guinea pig atria. Our results indicate that CSM bark extract exhibits antioxidant activity and might induce cardioprotective effect. PMID:23533692

Effects Of The Contingency For Homework Submission On Homework Submission And Quiz Performance In A College Course

PubMed Central

2005-01-01

Effects of the contingency for submission of homework assignments on the probability of assignment submission and on quiz grades were assessed in an undergraduate psychology course. Under an alternating treatments design, each student was assigned to a points condition for 5 of 10 quiz-related homework assignments corresponding to textbook chapters. Points were available for homework submission under this condition; points were not available under the no-points condition. The group-mean percentage of homework assignments submitted and quiz grades were higher for all chapters under the points condition than in the no-points condition. These findings, which were replicated in Experiment 2, demonstrate that homework submission was not maintained when the only consequences were instructor-provided feedback and expectation of improved quiz performance. PMID:15898476

Galactic and Intergalactic Magnetic Fields

NASA Astrophysics Data System (ADS)

Klein, U.; Fletcher, A.

This course-tested textbook conveys the fundamentals of magnetic fields and relativistic plasma in diffuse cosmic media, with a primary focus on phenomena that have been observed at different wavelengths. Theoretical concepts are addressed wherever necessary, with derivations presented in sufficient detail to be generally accessible. In the first few chapters the authors present an introduction to various astrophysical phenomena related to cosmic magnetism, with scales ranging from molecular clouds in star-forming regions and supernova remnants in the Milky Way, to clusters of galaxies. Later chapters address the role of magnetic fields in the evolution of the interstellar medium, galaxies and galaxy clusters. The book is intended for advanced undergraduate and postgraduate students in astronomy and physics and will serve as an entry point for those starting their first research projects in the field.

Validation of Metrics as Error Predictors

NASA Astrophysics Data System (ADS)

Mendling, Jan

In this chapter, we test the validity of metrics that were defined in the previous chapter for predicting errors in EPC business process models. In Section 5.1, we provide an overview of how the analysis data is generated. Section 5.2 describes the sample of EPCs from practice that we use for the analysis. Here we discuss a disaggregation by the EPC model group and by error as well as a correlation analysis between metrics and error. Based on this sample, we calculate a logistic regression model for predicting error probability with the metrics as input variables in Section 5.3. In Section 5.4, we then test the regression function for an independent sample of EPC models from textbooks as a cross-validation. Section 5.5 summarizes the findings.

Customization of Curriculum Materials in Science: Motives, Challenges, and Opportunities

NASA Astrophysics Data System (ADS)

Romine, William L.; Banerjee, Tanvi

2012-02-01

Exemplary science instructors use inquiry to tailor content to student's learning needs; traditional textbooks treat science as a set of facts and a rigid curriculum. Publishers now allow instructors to compile pieces of published and/or self-authored text to make custom textbooks. This brings numerous advantages, including the ability to produce smaller, cheaper text and added flexibility on the teaching models used. Moreover, the internet allows instructors to decentralize textbooks through easy access to educational objects such as audiovisual simulations, individual textbook chapters, and scholarly research articles. However, these new opportunities bring with them new problems. With educational materials easy to access, manipulate and duplicate, it is necessary to define intellectual property boundaries, and the need to secure documents against unlawful copying and use is paramount. Engineers are developing and enhancing information embedding technologies, including steganography, cryptography, watermarking, and fingerprinting, to label and protect intellectual property. While these are showing their utility in securing information, hackers continue to find loop holes in these protection schemes, forcing engineers to constantly assess the algorithms to make them as secure as possible. As newer technologies rise, people still question whether custom publishing is desirable. Many instructors see the process as complex, costly, and substandard in comparison to using traditional text. Publishing companies are working to improve attitudes through advertising. What lacks is peer reviewed evidence showing that custom publishing improves learning. Studies exploring the effect of custom course materials on student attitude and learning outcomes are a necessary next step.

Delayed Shock-induced Dust Formation in the Dense Circumstellar Shell Surrounding the Type IIn Supernova SN 2010jl

NASA Astrophysics Data System (ADS)

Sarangi, Arkaprabha; Dwek, Eli; Arendt, Richard G.

2018-05-01

The light curves of Type IIn supernovae are dominated by the radiative energy released through the interaction of the supernova shock waves with their dense circumstellar medium (CSM). The ultraluminous Type IIn supernova SN 2010jl exhibits an infrared emission component that is in excess of the extrapolated UV–optical spectrum as early as few weeks postexplosion. This emission has been considered by some as evidence for the rapid formation of dust in the cooling postshock CSM. We investigate the physical processes that may inhibit or facilitate the formation of dust in the CSM. When only radiative cooling is considered, the temperature of the dense shocked gas rapidly drops below the dust condensation temperature. However, by accounting for the heating of the postshock gas by the downstream radiation from the shock, we show that dust formation is inhibited until the radiation from the shock weakens as it propagates into the less dense outer regions of the CSM. In SN 2010jl, dust formation can therefore only commence after day ∼380. Only the IR emission since that epoch can be attributed to the newly formed CSM dust. Observations on day 460 and later show that the IR luminosity exceeds the UV–optical luminosity. The postshock dust cannot extinct the radiation emitted by the expanding SN shock. Therefore, its IR emission must be powered by an interior source, which we identify as the reverse shock propagating through the SN ejecta. IR emission before day 380 must therefore be an IR echo from preexisting CSM dust.

Analysis of insecticide resistance-related genes of the Carmine spider mite Tetranychus cinnabarinus based on a de novo assembled transcriptome.

PubMed

Xu, Zhifeng; Zhu, Wenyi; Liu, Yanchao; Liu, Xing; Chen, Qiushuang; Peng, Miao; Wang, Xiangzun; Shen, Guangmao; He, Lin

2014-01-01

The carmine spider mite (CSM), Tetranychus cinnabarinus, is an important pest mite in agriculture, because it can develop insecticide resistance easily. To gain valuable gene information and molecular basis for the future insecticide resistance study of CSM, the first transcriptome analysis of CSM was conducted. A total of 45,016 contigs and 25,519 unigenes were generated from the de novo transcriptome assembly, and 15,167 unigenes were annotated via BLAST querying against current databases, including nr, SwissProt, the Clusters of Orthologous Groups (COGs), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). Aligning the transcript to Tetranychus urticae genome, the 19255 (75.45%) of the transcripts had significant (e-value <10-5) matches to T. urticae DNA genome, 19111 sequences matched to T. urticae proteome with an average protein length coverage of 42.55%. Core Eukaryotic Genes Mapping Approach (CEGMA) analysis identified 435 core eukaryotic genes (CEGs) in the CSM dataset corresponding to 95% coverage. Ten gene categories that relate to insecticide resistance in arthropod were generated from CSM transcriptome, including 53 P450-, 22 GSTs-, 23 CarEs-, 1 AChE-, 7 GluCls-, 9 nAChRs-, 8 GABA receptor-, 1 sodium channel-, 6 ATPase- and 12 Cyt b genes. We developed significant molecular resources for T. cinnabarinus putatively involved in insecticide resistance. The transcriptome assembly analysis will significantly facilitate our study on the mechanism of adapting environmental stress (including insecticide) in CSM at the molecular level, and will be very important for developing new control strategies against this pest mite.

National Trends in Demographics and Outcomes Following Cervical Fusion for Cervical Spondylotic Myelopathy

PubMed Central

Vonck, Caroline E.; Tanenbaum, Joseph E.; Smith, Gabriel A.; Benzel, Edward C.; Mroz, Thomas E.; Steinmetz, Michael P.

2017-01-01

Study Design: Retrospective trends analysis. Objectives: Cervical fusion is a common adjunctive surgical modality used in the treatment of cervical spondylotic myelopathy (CSM). The purpose of this study was to quantify national trends in patient demographics, hospital characteristics, and outcomes in the surgical management of CSM. Methods: This was a retrospective study that used the National Inpatient Sample. The sample included all patients over 18 years of age with a diagnosis of CSM who underwent cervical fusion from 2003 to 2013. The outcome measures were in-hospital mortality, length of stay, and hospital charges. Chi-square tests were performed to compare categorical variables. Independent t tests were performed to compare continuous variables. Results: We identified 62 970 patients with CSM who underwent cervical fusion from 2003 to 2013. The number of fusions performed per year in the treatment of CSM increased from 3879 to 8181. The average age of all fusion patients increased from 58.2 to 60.6 years (P < .001). Length of stay did not change significantly from a mean of 3.7 days. In-hospital mortality decreased from 0.6% to 0.3% (P < .01). Hospital charges increased from $49 445 to $92 040 (P < .001). Conclusions: This study showed a dramatic increase in cervical fusions to treat CSM from 2003 to 2013 concomitant with increasing age of the patient population. Despite increases in average age and number of comorbidities, length of stay remained constant and a decrease in mortality was seen across the study period. However, hospital charges increased dramatically.

Family Access to a Dentist Study (FADS): A Multi-Center Randomized Controlled Trial

PubMed Central

Nelson, Suchitra; Riedy, Christine; Albert, Jeffrey M; Lee, Wonik; Slusar, Mary Beth; Curtan, Shelley; Ferretti, Gerald; Cunha-Cruz, Joana; Milgrom, Peter

2015-01-01

Introduction Many low-income parent/caregivers do not understand the importance of cavity-free primary (baby) teeth and the chronic nature of dental caries (tooth decay). As a consequence, dental preventive and treatment utilization is low even when children are screened in schools and referred for care. This study aims to test a referral letter and Dental Information Guide (DIG) designed using the Common-Sense Model of Self-Regulation (CSM) framework to improve caregivers’ illness perception of dental caries and increase utilization of care by children with restorative dental needs. Methods A multi-site randomized controlled trial with caregivers of Kindergarten to 4th grade children in urban Ohio and rural Washington State will compare five arms: (1) CSM referral letter alone; (2) CSM referral letter + DIG; (3) reduced CSM referral letter alone; (4) reduced CSM referral letter + DIG; (5) standard (control) referral. At baseline, children will be screened at school to determine restorative dental needs. If in need of treatment, caregivers will be randomized to study arms and an intervention packet will be sent home. The primary outcome will be dental care based on a change in oral health status by clinical examination 7 months post-screening (ICDAS sealant codes 1 and 2; restoration codes 3–8; extraction). Enrollment commenced summer 2015 with results in summer 2016. Conclusion This study uses the CSM framework to develop and test behavioral interventions to increase dental utilization among low-income caregivers. If effective this simple intervention has broad applicability in clinical and community-based settings. PMID:26500170

Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells.

PubMed

Fu, Shibo; Tar, Moses Tarndie; Melman, Arnold; Davies, Kelvin Paul

2014-08-01

Men with sickle cell disease (SCD) risk developing priapism. Recognizing that SCD is a disease of hypoxia, we investigated the effect of hypoxia on gene expression in corporal smooth muscle (CSM) cells. Rat CSM cells in vitro were treated with CoCl2 or low oxygen tension to mimic hypoxia. Hypoxic conditions increased expression of genes previously associated with priapism in animal models. Variable coding sequence a1 (Vcsa1; the rat opiorphin homologue, sialorphin), hypoxia-inducible factor 1a (Hif-1a), and A2B adenosine receptor (a2br) were increased by 10-, 4-, and 6-fold, respectively, by treatment with CoCl2, whereas low oxygen tension caused increases in expression of 3-, 4-, and 1.5-fold, respectively. Sialorphin-treated CSM cells increased expression of Hif-1a and a2br by 4-fold, and vcsa1-siRNA treatment reduced expression by ∼50%. Using a Hif-1a inhibitor, we demonstrated up-regulation of a2br by sialorphin is dependent on Hif-1a, and knockdown of vcsa1 expression with vcsa1-siRNA demonstrated that hypoxic-up-regulation of Hif-1a is dependent on vcsa1. In CSM from a SCD mouse, there was 15-fold up-regulation of opiorphin at a life stage prior to priapism. We conclude that in CSM, opiorphins are master regulators of the hypoxic response. Opiorphin up-regulation in response to SCD-associated hypoxia activates CSM "relaxant" pathways; excessive activation of these pathways results in priapism. © FASEB.

Family Access to a Dentist Study (FADS): A multi-center randomized controlled trial.

PubMed

Nelson, Suchitra; Riedy, Christine; Albert, Jeffrey M; Lee, Wonik; Slusar, Mary Beth; Curtan, Shelley; Ferretti, Gerald; Cunha-Cruz, Joana; Milgrom, Peter

2015-11-01

Many low-income parent/caregivers do not understand the importance of cavity-free primary (baby) teeth and the chronic nature of dental caries (tooth decay). As a consequence, dental preventive and treatment utilization is low even when children are screened in schools and referred for care. This study aims to test a referral letter and Dental Information Guide (DIG) designed using the Common-Sense Model of Self-Regulation (CSM) framework to improve caregivers' illness perception of dental caries and increase utilization of care by children with restorative dental needs. A multi-site randomized controlled trial with caregivers of Kindergarten to 4th grade children in urban Ohio and rural Washington State will compare five arms: (1) CSM referral letter alone; (2) CSM referral letter+DIG; (3) reduced CSM referral letter alone; (4) reduced CSM referral letter+DIG; and (5) standard (control) referral. At baseline, children will be screened at school to determine restorative dental needs. If in need of treatment, caregivers will be randomized to study arms and an intervention packet will be sent home. The primary outcome will be dental care based on a change in oral health status by clinical examination 7 months post-screening (ICDAS sealant codes 1 and 2; restoration codes 3-8; extraction). Enrollment commenced summer 2015 with results in summer 2016. This study uses the CSM framework to develop and test behavioral interventions to increase dental utilization among low-income caregivers. If effective this simple intervention has broad applicability in clinical and community-based settings. Copyright © 2015 Elsevier Inc. All rights reserved.

Socioeconomic and regional differences in the treatment of cervical spondylotic myelopathy

PubMed Central

Palejwala, Sheri K.; Rughani, Anand I.; Lemole, G. Michael; Dumont, Travis M.

2017-01-01

Background: Cervical spondylotic myelopathy (CSM) is the leading cause of spinal cord dysfunction in the world. Surgical treatment is both medically and economically advantageous, and can be achieved through multiple approaches, with or without fusion. We used the Nationwide Inpatient Sample (NIS) database to better elucidate regional and socioeconomic variances in the treatment of CSM. Methods: The NIS database was queried for elective admissions with a primary diagnosis of CSM (ICD-9 721.1). This was evaluated for patients who also carried a diagnosis of anterior (ICD-9 81.02) or posterior cervical fusion (ICD-9 81.03), posterior cervical laminectomy (ICD 03.09), or a combination. We then investigated variances including regional trends and disparities according to hospital and insurance types. Results: During 2002–2012, 50605 patients were electively admitted with a diagnosis of CSM. Anterior fusions were more common in Midwestern states and in nonteaching hospitals. Fusion procedures were used more frequently than other treatments in private hospitals and with private insurance. Median hospital charges were also expectedly higher for fusion procedures and combined surgical approaches. Combined approaches were found to be significantly greater in patients with concurrent diagnoses of ossification of the posterior longitudinal ligament (OPLL) and CSM. Ultimately, there has been an increased utilization of fusion procedures versus nonfusion treatments, over the past decade, for patients with cervical myelopathy. Conclusions: Fusion surgery is being increasingly used for the treatment of CSM. Expensive procedures are being performed more frequently in both private hospitals and for those with private insurance, whereas the most economical procedure, posterior cervical laminectomy, was underutilized. PMID:28607826

Global Positioning System (GPS) civil signal monitoring (CSM) trade study report

DOT National Transportation Integrated Search

2014-03-07

This GPS Civil Signal Monitoring (CSM) Trade Study has been performed at the direction of DOT/FAA Navigation Programs as the agency of reference for consolidating civil monitoring requirements on the Global Positioning System (GPS). The objective of ...

View of Skylab space station cluster in Earth orbit from CSM

NASA Image and Video Library

1974-02-08

SL4-143-4707 (8 Feb. 1974) --- An overhead view of the Skylab space station cluster in Earth orbit as photographed from the Skylab 4 Command and Service Modules (CSM) during the final fly-around by the CSM before returning home. The space station is contrasted against a cloud-covered Earth. Note the solar shield which was deployed by the second crew of Skylab and from which a micrometeoroid shield has been missing since the cluster was launched on May 14, 1973. The OWS solar panel on the left side was also lost on workshop launch day. Photo credit: NASA

The CSM testbed matrix processors internal logic and dataflow descriptions

NASA Technical Reports Server (NTRS)

Regelbrugge, Marc E.; Wright, Mary A.

1988-01-01

This report constitutes the final report for subtask 1 of Task 5 of NASA Contract NAS1-18444, Computational Structural Mechanics (CSM) Research. This report contains a detailed description of the coded workings of selected CSM Testbed matrix processors (i.e., TOPO, K, INV, SSOL) and of the arithmetic utility processor AUS. These processors and the current sparse matrix data structures are studied and documented. Items examined include: details of the data structures, interdependence of data structures, data-blocking logic in the data structures, processor data flow and architecture, and processor algorithmic logic flow.

The CSM testbed software system: A development environment for structural analysis methods on the NAS CRAY-2

NASA Technical Reports Server (NTRS)

Gillian, Ronnie E.; Lotts, Christine G.

1988-01-01

The Computational Structural Mechanics (CSM) Activity at Langley Research Center is developing methods for structural analysis on modern computers. To facilitate that research effort, an applications development environment has been constructed to insulate the researcher from the many computer operating systems of a widely distributed computer network. The CSM Testbed development system was ported to the Numerical Aerodynamic Simulator (NAS) Cray-2, at the Ames Research Center, to provide a high end computational capability. This paper describes the implementation experiences, the resulting capability, and the future directions for the Testbed on supercomputers.

Spatio-temporal evaluation of plant height in corn via unmanned aerial systems

NASA Astrophysics Data System (ADS)

Varela, Sebastian; Assefa, Yared; Vara Prasad, P. V.; Peralta, Nahuel R.; Griffin, Terry W.; Sharda, Ajay; Ferguson, Allison; Ciampitti, Ignacio A.

2017-07-01

Detailed spatial and temporal data on plant growth are critical to guide crop management. Conventional methods to determine field plant traits are intensive, time-consuming, expensive, and limited to small areas. The objective of this study was to examine the integration of data collected via unmanned aerial systems (UAS) at critical corn (Zea mays L.) developmental stages for plant height and its relation to plant biomass. The main steps followed in this research were (1) workflow development for an ultrahigh resolution crop surface model (CSM) with the goal of determining plant height (CSM-estimated plant height) using data gathered from the UAS missions; (2) validation of CSM-estimated plant height with ground-truthing plant height (measured plant height); and (3) final estimation of plant biomass via integration of CSM-estimated plant height with ground-truthing stem diameter data. Results indicated a correlation between CSM-estimated plant height and ground-truthing plant height data at two weeks prior to flowering and at flowering stage, but high predictability at the later growth stage. Log-log analysis on the temporal data confirmed that these relationships are stable, presenting equal slopes for both crop stages evaluated. Concluding, data collected from low-altitude and with a low-cost sensor could be useful in estimating plant height.

Arabic versions of the sleep timing questionnaire and the composite scale of morningness.

PubMed

Mansour, Hader; Tobar, Salwa; Fathi, Warda; Ibrahim, Ibtihal; Wood, Joel; Elassy, Mai; Elsayed, Hanan; Yassin, Amal; Salah, Hala; Eissa, Ahmed; El-Boraie, Hala; El-Boraie, Osama; Dobea, Ahmed; Osama, Haitham; Gomaa, Zeinab; El-Bahaei, Wafaa; Monk, Timothy H; Nimgaonkar, Vishwajit L

2015-02-01

To develop Arabic versions of English language questionnaires to estimate morningness/eveningness and sleep variables. We translated the Composite scale of morningness (CSM) and the sleep timing questionnaire (STQ) [with added siesta questions] into Arabic; the Arabic versions were then back translated. The revised Arabic and the original English versions were next administered to bi-lingual Egyptians using a crossover design (n=25). The Arabic versions of both scales were subsequently administered to an independent Egyptian sample (n=79) and the siesta variables examined in relation to the CSM. Satisfactory correlations were present between the English and Arabic versions for total CSM scores (Spearman's ρ=0.90, p<0.001). All but one of the STQ variables were significantly correlated (Spearman's ρ=0.45-0.88, p≤0.05). In the Arabic version, the frequency of siesta naps per week was significantly correlated with the total CSM score, with evening types taking more naps (Spearman's ρ=-0.23, p≤0.05). Arabic versions of the STQ and CSM have been developed in Egypt, and are freely available. They can be used for behavioral research related to sleep and circadian function and can be adapted for use in other Arab speaking populations. Copyright © 2014 Elsevier B.V. All rights reserved.

Applicability of the Common Safety Method for Risk Evaluation and Assessment (CSM-RA) to the Space Domain

NASA Astrophysics Data System (ADS)

Moreira, Francisco; Silva, Nuno

2016-08-01

Safety systems require accident avoidance. This is covered by application standards, processes, techniques and tools that support the identification, analysis, elimination or reduction to an acceptable level of system risks and hazards. Ideally, a safety system should be free of hazards. However, both industry and academia have been struggling to ensure appropriate risk and hazard analysis, especially in what concerns completeness of the hazards, formalization, and timely analysis in order to influence the specifications and the implementation. Such analysis is also important when considering a change to an existing system. The Common Safety Method for Risk Evaluation and Assessment (CSM- RA) is a mandatory procedure whenever any significant change is proposed to the railway system in a European Member State. This paper provides insights on the fundamentals of CSM-RA based and complemented with Hazard Analysis. When and how to apply them, and the relation and similarities of these processes with industry standards and the system life cycles is highlighted. Finally, the paper shows how CSM-RA can be the basis of a change management process, guiding the identification and management of the hazards helping ensuring the similar safety level as the initial system. This paper will show how the CSM-RA principles can be used in other domains particularly for space system evolution.

Comparative Analysis of VOCs in Exhaled Breath of Amyotrophic Lateral Sclerosis and Cervical Spondylotic Myelopathy Patients.

PubMed

Wang, Changsong; Li, Mingjuan; Jiang, Hongquan; Tong, Hongshuang; Feng, Yue; Wang, Yue; Pi, Xin; Guo, Lei; Nie, Maomao; Feng, Honglin; Li, Enyou

2016-05-23

Amyotrophic lateral sclerosis (ALS) is an incurable neurological degenerative disease. It can cause irreversible neurological damage to motor neurons; typical symptoms include muscle weakness and atrophy, bulbar paralysis and pyramidal tract signs. The ALS-mimicking disease cervical spondylotic myelopathy (CSM) presents similar symptoms, but analysis of breath volatile organic compounds (VOCs) can potentially be used to distinguish ALS from CSM. In this study, breath samples were collected from 28 ALS and 13 CSM patients. Subsequently, gas chromatography/mass spectrometry (GCMS) was used to analyze breath VOCs. Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLSDA) were the statistical methods used to process the final data. We identified 4 compounds with significantly decreased levels in ALS patients compared with CSM controls: (1) carbamic acid, monoammonium salt; (2) 1-alanine ethylamide, (S)-; (3) guanidine, N,N-dimethyl-; and (4) phosphonic acid, (p-hydroxyphenyl)-. Currently, the metabolic origin of the VOCs remains unclear; however, several pathways might explain the decreasing trends observed. The results of this study demonstrate that there are specific VOC profiles associated with ALS and CSM patients that can be used to differentiate between the two. In addition, these metabolites could contribute to a better understanding of the underlying pathophysiological mechanisms of ALS.

X-Ray Emission from Supernovae in Dense Circumstellar Matter Environments: A Search for Collisionless Shock

NASA Technical Reports Server (NTRS)

Ofek, E.O; Fox, D.; Cenko, B.; Sullivan, M.; Gnat, O.; Frail A.; Horesh, A.; Corsi, A; Quimby, R. M.; Gehrels, N.;

BOOK REVIEW: Fundamentals of Plasma Physics

NASA Astrophysics Data System (ADS)

Cargill, P. J.

2007-02-01

The widespread importance of plasmas in many areas of contemporary physics makes good textbooks in the field that are both introductory and comprehensive invaluable. This new book by Paul Bellen from CalTech by and large meets these goals. It covers the traditional textbook topics such as particle orbits, the derivation of the MHD equations from Vlasov theory, cold and warm plasma waves, Landau damping, as well as in the later chapters less common subjects such as magnetic helicity, nonlinear processes and dusty plasmas. The book is clearly written, neatly presented, and each chapter has a number of exercises or problems at their end. The author has also thankfully steered clear of the pitfall of filling the book with his own research results. The preface notes that the book is designed to provide an introduction to plasma physics for final year undergraduate and post-graduate students. However, it is difficult to see many physics undergraduates now at UK universities getting to grips with much of the content since their mathematics is not of a high enough standard. Students in Applied Mathematics departments would certainly fare better. An additional problem for the beginner is that some of the chapters do not lead the reader gently into a subject, but begin with quite advanced concepts. Being a multi-disciplinary subject, beginners tend to find plasma physics quite hard enough even when done simply. For postgraduate students these criticisms fade away and this book provides an excellent introduction. More senior researchers should also enjoy the book, especially Chapters 11-17 where more advanced topics are discussed. I found myself continually comparing the book with my favourite text for many years, `The Physics of Plasmas' by T J M Boyd and J J Sanderson, reissued by Cambridge University Press in 2003. Researchers would want both books on their shelves, both for the different ways basic plasma physics is covered, and the diversity of more advanced topics. For the undergraduate level, I would find it easier to construct an introductory course from Boyd and Sanderson.

Continuum Level Density in Complex Scaling Method

NASA Astrophysics Data System (ADS)

Suzuki, R.; Myo, T.; Katō, K.

2005-11-01

A new calculational method of continuum level density (CLD) at unbound energies is studied in the complex scaling method (CSM). It is shown that the CLD can be calculated by employing the discretization of continuum states in the CSM without any smoothing technique.

Multiple animal studies for medical chemical defense program in soldier/patient decontamination and drug development. Task order 85-10. Final report, 1 December 1984-1 April 1987

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joiner, R.L.; Harroff, H.H.; Snider, H.

1987-12-04

A rabbit model has been developed and validated for screening noninvasive candidate decontamination systems for their efficacies against topical exposure to the organophosphage chemical surety materiel (CSM), GD, polymer-thickened GD (TGD), and VX. CSM was applied to rabbits in groups of 8 on their clipped dorsa over a range of doses. Dose sites were decontaminated beginning 2 minutes after exposure with both components of the M258A1 standard field kit in the recommended sequence. Replicate LD50s were calculated for each CSM with probit analyses of the doses and lethality rates from replicate studies. A composite LD50 was calculated from the datamore » pooled across replicates for each CSM. The composite LD50 was validated for each CSM by comparing the lethality rate obtained in three replicates of 8 animals each with the population mean of 50 percent. The LD50 values obtained for the three CSM tested produced valid mortality ratios when compared to the population mean. Thus the screen is ready to test candidate decontamination systems. The screen compares the lethality rate obtained from 8 animals each dosed at the established M258A1 LD50 and decontaminated according to the manufacturer's instructions with a candidate system against the population mean of 50 percent. An M258A1-decontaminated control group of 8 animals is included to check for drift via a control chart method. Any candidate decontamination system that is as effective as or more effective than the dual-component M258A1 standard passes the screen and is a candidate for further testing.« less

Cervical Spondylotic Myelopathy Surgical (CSM-S) Trial: Randomized Controlled Trial Design and Rationale

PubMed Central

Ghogawala, Zoher; Benzel, Edward C.; Heary, Robert F.; Riew, K. Daniel; Albert, Todd J.; Butler, William E.; Barker, Fred G.; Heller, John G.; McCormick, Paul C.; Whitmore, Robert G.; Freund, Karen M.; Schwartz, J. Sanford

2014-01-01

Background Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in the world. There is significant practice variation and uncertainty as to the optimal surgical approach for treating CSM. Objective The primary objective is to determine if ventral surgery is associated with superior SF-36 Physical Component Summary (PCS) outcome at one year follow-up compared to dorsal (laminectomy/fusion or laminoplasty) surgery for the treatment of CSM. The study will also investigate whether post-operative sagittal balance is an independent predictor of overall outcome and will compare health resource utilization for ventral and dorsal procedures. Methods The study is a randomized, controlled trial with a nonrandomized arm for patients who are eligible but decline randomization. Two hundred fifty patients (159 randomized) with CSM from 11 sites will be recruited over 18 months. The primary outcome is the Short Form-36 PCS score. Secondary outcomes include disease specific outcomes, overall health-related quality of life (EuroQol-5D), and health resource utilization. Expected Outcomes This will be the first randomized controlled trial to compare directly the health-related quality of life outcomes for ventral versus dorsal surgery for treating CSM. Discussion An NIH-funded (1R13AR065834-01) investigator meeting was held prior to initiating the trial in order to bring multiple stakeholders together to finalize the study protocol. Study investigators, coordinators, and major stakeholders were able to attend and discuss strengths, limitations, and concerns regarding the study. The final protocol was approved for funding by PCORI (CE-1304-6173). The RCT began enrollment on April 1, 2014. PMID:24991714

SN 2013fs and SN 2013fr: exploring the circumstellar-material diversity in Type II supernovae

NASA Astrophysics Data System (ADS)

Bullivant, Christopher; Smith, Nathan; Williams, G. Grant; Mauerhan, Jon C.; Andrews, Jennifer E.; Fong, Wen-Fai; Bilinski, Christopher; Kilpatrick, Charles D.; Milne, Peter A.; Fox, Ori D.; Cenko, S. Bradley; Filippenko, Alexei V.; Zheng, WeiKang; Kelly, Patrick L.; Clubb, Kelsey I.

2018-05-01

We present photometry and spectroscopy of SN 2013fs and SN 2013fr in the first ˜100 d post-explosion. Both objects showed transient, relatively narrow H α emission lines characteristic of SNe IIn, but later resembled normal SNe II-P or SNe II-L, indicative of fleeting interaction with circumstellar material (CSM). SN 2013fs was discovered within 8 h of explosion; one of the earliest SNe discovered thus far. Its light curve exhibits a plateau, with spectra revealing strong CSM interaction at early times. It is a less luminous version of the transitional SN IIn PTF11iqb, further demonstrating a continuum of CSM interaction intensity between SNe II-P and SNe IIn. It requires dense CSM within 6.5 × 1014 cm of the progenitor, from a phase of advanced pre-SN mass loss beginning shortly before explosion. Spectropolarimetry of SN 2013fs shows little continuum polarization (˜0.5 per cent, consistent with zero), but noticeable line polarization during the plateau phase. SN 2013fr morphed from an SN IIn at early times to an SN II-L. After the first epoch, its narrow lines probably arose from host-galaxy emission, but the bright, narrow H α emission at early times may be intrinsic to the SN. As for SN 2013fs, this would point to a short-lived phase of strong CSM interaction if proven to be intrinsic, suggesting a continuum between SNe IIn and SNe II-L. It is a low-velocity SN II-L like SN 2009kr, but more luminous. SN 2013fr also developed an infrared excess at later times, due to warm CSM dust that requires a more sustained phase of strong pre-SN mass loss.

Pricing products: juxtaposing affordability with quality appeal.

PubMed

1984-01-01

Choosing appropriate product prices is 1 of the most crucial steps in creating an effective contraceptive social marketing (CSM) sales campaign. The Social Marketing Forum conducted an informal survey of social marketing project managers, international contractors, and marketing consultants to determine how CSM programs cope with pricing problems and ways to circumvent some obstacles. According to Diana Altman, a family planning consultant, low prices that make products available to needy individuals are more important than the program's self sufficiency, yet if prices are too low, consumers think the products were unusable in the US and thus were dumped on local markets. Other key factors include commercial competition, spiraling inflation rates, and problems with rising prices and retailer/distributor margins. A sampling of per capita gross national products indicates the poverty level of most CSM projects' target market. Consequently, CSM projects must set low pices, regardless of program operating costs. The goal often is to increase the demand and availability for contraceptives. The fact that social marketing products must pass through retail networks to reach consumers complicates the pricing equation. To deal with the problem, India's Nirodh program gives a 25% margin to distributors/wholesalers, compared to 6% offered on most other goods. Retailers also receive a 25% margin, more than double the commercial rate. Once prices are set, increases pose hazards. Local government approval often is a prerequisite and can require lengthy negotiations. Market studies remain a valuable approach to effective pricing, according to PNA's Mallamad and other research consultants. They cite such effective research strategies as test marketing products and asking consumers how prices affect buying habits. Further, CSM projects can jump over some pricing hurdles through creative marketing. An effective pricing strategy alone cannot produce a successful CSM program. Pricing must accompany such factors as strong advertising, committed management, and adept salespersons.

Measuring the Progenitor Masses and Dense Circumstellar Material of Type II Supernovae

NASA Astrophysics Data System (ADS)

Morozova, Viktoriya; Piro, Anthony L.; Valenti, Stefano

2018-05-01

Recent modeling of hydrogen-rich Type II supernova (SN II) light curves suggests the presence of dense circumstellar material (CSM) surrounding the exploding progenitor stars. This has important implications for the activity and structure of massive stars near the end of their lives. Since previous work focused on just a few events, here we expand to a larger sample of 20 well-observed SNe II. For each event we are able to constrain the progenitor zero-age main-sequence (ZAMS) mass, explosion energy, and the mass and radial extent of the dense CSM. We then study the distribution of each of these properties across the full sample of SNe. The inferred ZAMS masses are found to be largely consistent with a Salpeter distribution with minimum and maximum masses of 10.4 and 22.9 M ⊙, respectively. We also compare the individual ZAMS masses we measure with specific SNe II that have pre-explosion imaging to check their consistency. Our masses are generally comparable to or higher than the pre-explosion imaging masses, potentially helping ease the red supergiant problem. The explosion energies vary from (0.1–1.3) × 1051 erg, and for ∼70% of the SNe we obtain CSM masses in the range between 0.18 and 0.83 M ⊙. We see a potential correlation between the CSM mass and explosion energy, which suggests that pre-explosion activity has a strong impact on the structure of the star. This may be important to take into account in future studies of the ability of the neutrino mechanism to explode stars. We also see a possible correlation between the CSM radial extent and ZAMS mass, which could be related to the time with respect to explosion when the CSM is first generated.

Psychometric properties of Persian version of Composite Scale of Morningness.

PubMed

Rahimi Pordanjani, Tayebe; Ebrahimi, Ali Mohamadzade

2017-02-01

Morningness-eveningness preference is commonly measured by questionnaires such as the Composite Scale of Morningness (CSM). The purpose of this study is to assess the Persian translation of the CSM and explore its psychometric properties. Participants consisted of 288 students at the University of Bojnord, Iran. Of the participants selected, 47.6% were female, 52.4% were male, and all were aged between 18 and 24 (20.09±1.32). Participants were selected using the stratified random sampling method. The scale was translated into Persian using the parallel translation method. SPSS-22 and AMOS-22 were used for analyses. Mean CSM scores were 31.43±6.32 in a range of 14-50. Internal reliability, as measured by Cronbach's α, was 0.790, which fits well with previous studies undertaken in many countries. The factor analysis revealed a two-factor structure based on parallel analysis: one factor was labeled as "morning affect" and the other as "self-assessment/activity planning." Also, the confirmatory factor analysis supported the two-factor model fit. Construct validity was also evaluated by the MEQ with the results showing that correlations were comparable to other studies (r=0.76). Results did not show any significant correlation between age (r=0.041; P=0.487) and the CSM scores. According to the results of the t-test, women and men were not significantly different in terms of the CSM scores (t=-0.264; P=0.792). The Persian version of the CSM is freely available and can be adopted for behavioral research related to sleep and circadian function and also applied to other Persian-speaking populations. Copyright © 2016 Elsevier B.V. All rights reserved.

Selective protein extraction from Chlorobium tepidum chlorosomes using detergents. Evidence that CsmA forms multimers and binds bacteriochlorophyll a.

PubMed

Bryant, Donald A; Vassilieva, Elena V; Frigaard, Niels-Ulrik; Li, Hui

2002-12-03

Chlorosomes of the photosynthetic green sulfur bacterium Chlorobium tepidum consist of bacteriochlorophyll (BChl) c aggregates that are surrounded by a lipid-protein monolayer envelope that contains ten different proteins. Chlorosomes also contain a small amount of BChl a, but the organization and location of this BChl a are not yet clearly understood. Chlorosomes were treated with sodium dodecyl sulfate (SDS), Lubrol PX, or Triton X-100, separately or in combination with 1-hexanol, and the extracted components were separated from the residual chlorosomes by ultrafiltration on centrifugal filters. When chlorosomes were treated with low concentrations of SDS, all proteins except CsmA were extracted. However, this treatment did not significantly alter the size and shape of the chlorosomes, did not extract the BChl a, and caused only minor changes in the absorption spectrum of the chlorosomes. Cross-linking studies with SDS-treated chlorosomes revealed the presence of multimers of the major chlorosome protein, CsmA, up to homooctamers. Extraction of chlorosomes with SDS and 1-hexanol solubilized all ten chlorosome envelope proteins as well as BChl a. Although the size and shape of these extracted chlorosomes did not initially differ significantly from untreated chlorosomes, the extracted chlorosomes gradually disintegrated, and rod-shaped BChl c aggregates were sometimes observed. These results strongly suggest that CsmA binds the BChl a in Chlorobium-type chlorosomes and further indicate that none of the nine other chlorosome envelope proteins are absolutely required for maintaining the shape and integrity of chlorosomes. Quantitative estimates suggest that chlorosomes contain approximately equimolar amounts of CsmA and BChl a and that roughly one-third of the surface of the chlorosome is covered by CsmA.

Morningness-eveningness and affective temperaments assessed by the Temperament Evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A).

PubMed

Chrobak, Adrian Andrzej; Tereszko, Anna; Dembinska-Krajewska, Daria; Arciszewska, Aleksandra; Siwek, Marcin; Dudek, Dominika; Rybakowski, Janusz

2017-01-01

Chronotype is a stable trait presenting one's circardian preference. Since chronotype disturbances are common in patients with affective disorders, our aim is to evaluate chronotypes related to affective temperaments, measured with the temperament evaluation of Memphis, Pisa and San Diego-Autoquestionnaire (TEMPS-A). The study included 618 subjects (151 men and 467 women) within the framework of web-based design. They all fulfilled a questionnaire, consisting of the Composite Scale of Morningness (CSM), Sleep Wake Pattern Assessment Questionnaire (SWPAQ), and the TEMPS-A scale. Multiple regression models revealed that after controlling for age and gender: irritable and cyclothymic temperaments were negatively associated with total CSM score, CSM morning affect and circadian preference components, Sleepability (S), Vigilance (V), Wakeability (W) and positively with Morningness (M) and Eveningness (E) subscales of SWPAQ; anxious temperament was negatively associated with total CSM scores, CSM morning affect and with S, V, W subscales of SWPAQ; depressive temperament was negatively associated with Falling asleep, S, V, W subscales of SWPAQ; hyperthymic temperament was positively associated with CSM morning affect and V, W and negatively with M subscales of SWPAQ. The results show distinctiveness of the associations between hyperthymic temperament and circadian preferences, compared to all other TEMPS-A temperaments (depressive, cyclothymic, irritable and anxious). In the CMS scale, only hyperthymic temperament was related to morning affect. In the SWPAQ scale, hyperthymic temperament was the only one associated with earlier morningness (earlier wake up time preference), increased parameters of vigor - wakeability, vigilance, and also the only one not associated with decreased plasticity of circadian rhythm (sleepability and falling asleep). Results also point to some similarities between cyclothymic and irritable temperaments in some aspects of the chronotype.

Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells

PubMed Central

Fu, Shibo; Tar, Moses Tarndie; Melman, Arnold; Davies, Kelvin Paul

2014-01-01

Men with sickle cell disease (SCD) risk developing priapism. Recognizing that SCD is a disease of hypoxia, we investigated the effect of hypoxia on gene expression in corporal smooth muscle (CSM) cells. Rat CSM cells in vitro were treated with CoCl2 or low oxygen tension to mimic hypoxia. Hypoxic conditions increased expression of genes previously associated with priapism in animal models. Variable coding sequence a1 (Vcsa1; the rat opiorphin homologue, sialorphin), hypoxia-inducible factor 1a (Hif-1a), and A2B adenosine receptor (a2br) were increased by 10-, 4-, and 6-fold, respectively, by treatment with CoCl2, whereas low oxygen tension caused increases in expression of 3-, 4-, and 1.5-fold, respectively. Sialorphin-treated CSM cells increased expression of Hif-1a and a2br by 4-fold, and vcsa1-siRNA treatment reduced expression by ∼50%. Using a Hif-1a inhibitor, we demonstrated up-regulation of a2br by sialorphin is dependent on Hif-1a, and knockdown of vcsa1 expression with vcsa1-siRNA demonstrated that hypoxic-up-regulation of Hif-1a is dependent on vcsa1. In CSM from a SCD mouse, there was 15-fold up-regulation of opiorphin at a life stage prior to priapism. We conclude that in CSM, opiorphins are master regulators of the hypoxic response. Opiorphin up-regulation in response to SCD-associated hypoxia activates CSM “relaxant” pathways; excessive activation of these pathways results in priapism.—Fu, S., Tar, M. T., Melman, A., Davies, K. P. Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. PMID:24803544

Stripped-envelope supernova SN 2004dk is now interacting with hydrogen-rich circumstellar material

NASA Astrophysics Data System (ADS)

Mauerhan, Jon C.; Filippenko, Alexei V.; Zheng, WeiKang; Brink, Thomas; Graham, Melissa L.; Shivvers, Isaac; Clubb, Kelsey

2018-05-01

The dominant mechanism and time scales over which stripped-envelope supernovae (SNe) progenitor stars shed their hydrogen envelopes are uncertain. Observations of Type Ib and Ic SNe at late phases could reveal the optical signatures of interaction with distant circumstellar material (CSM) providing important clues on the origin of the necessary pre-SN mass loss. We report deep late-time optical spectroscopy of the Type Ib explosion SN 2004dk 4684 days (13 years) after discovery. We detect strong Hα emission with an intermediate line width of ˜400 km s-1 and luminosity ˜2.5 × 1039 erg s-1, signaling that the SN blast wave has caught up with the hydrogen-rich CSM lost by the progenitor system. The line luminosity is the highest ever reported for a SN at this late stage. Prominent emission features of He I, Fe, and Ca are also detected. The spectral characteristics are consistent with CSM energized by the forward shock, and resemble the late-time spectra of the persistently interacting Type IIn SNe 2005ip and 1988Z. We suggest that the onset of interaction with H-rich CSM was associated with a previously reported radio rebrightening at ˜1700 days. The data indicate that the mode of pre-SN mass loss was a relatively slow dense wind that persisted millennia before the SN, followed by a short-lived Wolf-Rayet phase that preceded core-collapse and created a cavity within an extended distribution of CSM. We also present new spectra of SNe 2014C, PTF11iqb, and 2009ip, all of which also exhibit continued interaction with extended CSM distributions.

Predicting survival of men with recurrent prostate cancer after radical prostatectomy.

PubMed

Dell'Oglio, Paolo; Suardi, Nazareno; Boorjian, Stephen A; Fossati, Nicola; Gandaglia, Giorgio; Tian, Zhe; Moschini, Marco; Capitanio, Umberto; Karakiewicz, Pierre I; Montorsi, Francesco; Karnes, R Jeffrey; Briganti, Alberto

2016-02-01

To develop and externally validate a novel nomogram aimed at predicting cancer-specific mortality (CSM) after biochemical recurrence (BCR) among prostate cancer (PCa) patients treated with radical prostatectomy (RP) with or without adjuvant external beam radiotherapy (aRT) and/or hormonal therapy (aHT). The development cohort included 689 consecutive PCa patients treated with RP between 1987 and 2011 with subsequent BCR, defined as two subsequent prostate-specific antigen values >0.2 ng/ml. Multivariable competing-risks regression analyses tested the predictors of CSM after BCR for the purpose of 5-year CSM nomogram development. Validation (2000 bootstrap resamples) was internally tested. External validation was performed into a population of 6734 PCa patients with BCR after treatment with RP at the Mayo Clinic from 1987 to 2011. The predictive accuracy (PA) was quantified using the receiver operating characteristic-derived area under the curve and the calibration plot method. The 5-year CSM-free survival rate was 83.6% (confidence interval [CI]: 79.6-87.2). In multivariable analyses, pathologic stage T3b or more (hazard ratio [HR]: 7.42; p = 0.008), pathologic Gleason score 8-10 (HR: 2.19; p = 0.003), lymph node invasion (HR: 3.57; p = 0.001), time to BCR (HR: 0.99; p = 0.03) and age at BCR (HR: 1.04; p = 0.04), were each significantly associated with the risk of CSM after BCR. The bootstrap-corrected PA was 87.4% (bootstrap 95% CI: 82.0-91.7%). External validation of our nomogram showed a good PA at 83.2%. We developed and externally validated the first nomogram predicting 5-year CSM applicable to contemporary patients with BCR after RP with or without adjuvant treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

Hybrid Corpectomy and Disc Arthroplasty for Cervical Spondylotic Myelopathy Caused by Ossification of Posterior Longitudinal Ligament and Disc Herniation.

PubMed

Chang, Huang-Chou; Tu, Tsung-Hsi; Chang, Hsuan-Kan; Wu, Jau-Ching; Fay, Li-Yu; Chang, Peng-Yuan; Wu, Ching-Lan; Huang, Wen-Cheng; Cheng, Henrich

2016-11-01

The combination of anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF) has been demonstrated to be effective for multilevel cervical spondylotic myelopathy (CSM); however, the combination of ACCF and cervical disc arthroplasty (CDA) for 3-level CSM has never been addressed. Consecutive patients (>18 years of age) with CSM caused by segmental ossification of posterior longitudinal ligament (OPLL) and degenerative disc disease (DDD) were reviewed. Inclusion criteria were patients who underwent hybrid ACCF and CDA surgery for symptomatic 3-level CSM with OPLL and DDD. Medical and radiologic records were reviewed retrospectively. A total of 15 patients were analyzed with a mean follow-up of 18.1 ± 7.42 months. Every patient had hybrid surgery composed of 1-level ACCF (for segmental-type OPLL causing spinal stenosis) and 1-level CDA at the adjacent level (for DDD causing stenosis). All clinical outcomes, including visual analogue scale of neck and arm pain, Neck Disability Index, Japanese Orthopedic Association scores, and Nurick scores of myelopathy, demonstrated significant improvement at 12 months after surgery. All patients (100%) achieved arthrodesis for the ACCF (instrumented) and preserved mobility for CDA (preoperation 6.2 ± 3.81° vs. postoperation 7.0 ± 4.18°; P = 0.579). For patients with multilevel CSM caused by segmental OPLL and DDD, the hybrid surgery of ACCF and CDA demonstrated satisfactory clinical and radiologic outcomes. Moreover, although located next to each other, the instrumented ACCF construct and CDA still achieved solid arthrodesis and preserved mobility, respectively. Therefore, hybrid surgery may be a reasonable option for the management of CSM with OPLL. Copyright © 2016 Elsevier Inc. All rights reserved.

CSM research: Methods and application studies

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.

1989-01-01

Computational mechanics is that discipline of applied science and engineering devoted to the study of physical phenomena by means of computational methods based on mathematical modeling and simulation, utilizing digital computers. The discipline combines theoretical and applied mechanics, approximation theory, numerical analysis, and computer science. Computational mechanics has had a major impact on engineering analysis and design. When applied to structural mechanics, the discipline is referred to herein as computational structural mechanics. Complex structures being considered by NASA for the 1990's include composite primary aircraft structures and the space station. These structures will be much more difficult to analyze than today's structures and necessitate a major upgrade in computerized structural analysis technology. NASA has initiated a research activity in structural analysis called Computational Structural Mechanics (CSM). The broad objective of the CSM activity is to develop advanced structural analysis technology that will exploit modern and emerging computers, such as those with vector and/or parallel processing capabilities. Here, the current research directions for the Methods and Application Studies Team of the Langley CSM activity are described.

Handling Late Changes to Titan Science

NASA Technical Reports Server (NTRS)

Pitesky, Jo Eliza; Steadman, Kim; Ray, Trina; Burton, Marcia

2014-01-01

The Cassini mission has been in orbit for eight years, returning a wealth of scientific data from Titan and the Saturnian system. The mission, a cooperative undertaking between NASA, ESA and ASI, is currently in its second extension of the prime mission. The Cassini Solstice Mission (CSM) extends the mission's lifetime until Saturn's northern summer solstice in 2017. The Titan Orbital Science Team (TOST) has the task of integrating the science observations for all 56 targeted Titan flybys in the CSM. In order to balance Titan science across the entire set of flybys during the CSM, to optimize and influence the Titan flyby altitudes, and to decrease the future workload, TOST went through a "jumpstart" process before the start of the CSM. The "jumpstart" produced Master Timelines for each flyby, identifying prime science observations and allocating control of the spacecraft attitude to specific instrument teams. Three years after completing this long-range plan, TOST now faces a new challenge: incorporating changes into the Titan Science Plan without undoing the balance achieved during the jumpstart.

SN 2010jl: Optical to Hard X-Ray Observations Reveal an Explosion Embedded in a Ten Solar Mass Cocoon

NASA Astrophysics Data System (ADS)

Ofek, Eran O.; Zoglauer, Andreas; Boggs, Steven E.; Barriére, Nicolas M.; Reynolds, Stephen P.; Fryer, Chris L.; Harrison, Fiona A.; Cenko, S. Bradley; Kulkarni, Shrinivas R.; Gal-Yam, Avishay; Arcavi, Iair; Bellm, Eric; Bloom, Joshua S.; Christensen, Finn; Craig, William W.; Even, Wesley; Filippenko, Alexei V.; Grefenstette, Brian; Hailey, Charles J.; Laher, Russ; Madsen, Kristin; Nakar, Ehud; Nugent, Peter E.; Stern, Daniel; Sullivan, Mark; Surace, Jason; Zhang, William W.

2014-01-01

Some supernovae (SNe) may be powered by the interaction of the SN ejecta with a large amount of circumstellar matter (CSM). However, quantitative estimates of the CSM mass around such SNe are missing when the CSM material is optically thick. Specifically, current estimators are sensitive to uncertainties regarding the CSM density profile and the ejecta velocity. Here we outline a method to measure the mass of the optically thick CSM around such SNe. We present new visible-light and X-ray observations of SN 2010jl (PTF 10aaxf), including the first detection of an SN in the hard X-ray band using NuSTAR. The total radiated luminosity of SN 2010jl is extreme—at least 9 × 1050 erg. By modeling the visible-light data, we robustly show that the mass of the circumstellar material within ~1016 cm of the progenitor of SN 2010jl was in excess of 10 M ⊙. This mass was likely ejected tens of years prior to the SN explosion. Our modeling suggests that the shock velocity during shock breakout was ~6000 km s-1, decelerating to ~2600 km s-1 about 2 yr after maximum light. Furthermore, our late-time NuSTAR and XMM spectra of the SN presumably provide the first direct measurement of SN shock velocity 2 yr after the SN maximum light—measured to be in the range of 2000-4500 km s-1 if the ions and electrons are in equilibrium, and >~ 2000 km s-1 if they are not in equilibrium. This measurement is in agreement with the shock velocity predicted by our modeling of the visible-light data. Our observations also show that the average radial density distribution of the CSM roughly follows an r -2 law. A possible explanation for the >~ 10 M ⊙ of CSM and the wind-like profile is that they are the result of multiple pulsational pair instability events prior to the SN explosion, separated from each other by years.

The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence

PubMed Central

2014-01-01

Background The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM helicase when DNA synthesis is prohibited. Keeping the replication machinery intact allows restart of the replication fork when the block is relieved. Although the subunits of the Tof1/Csm3/Mrc1 complex are well studied, the impact of every single subunit on the triple complex formation and function needs to be established. Findings This work studies the cellular localization and the chromatin binding of GFP-tagged subunits when the complex is intact and when a subunit is missing. We demonstrate that the complex is formed in cell nucleus, not the cytoplasm, as Tof1, Csm3 and Mrc1 enter the nucleus independently from one another. Via in situ chromatin binding assay we show that a Tof1-Csm3 dimer formation and chromatin binding is required to ensure the attachment of Mrc1 to chromatin. Our study indicates that the translocation into the nucleus is not the process to regulate the timing of chromatin association of Mrc1. We also studied the nuclear behavior of Mrc1 subunit in the process of adaptation to the presence hydroxyurea. Our results indicate that after prolonged HU incubation, cells bypass the S-phase checkpoint and proceed throughout the cell cycle. This process is accompanied by Mrc1 chromatin detachment and Rad53 dephosphorylation. Conclusions In S. cerevisiae the subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3 independently enter the cell nucleus, where a Tof1-Csm3 dimer is formed to ensure the chromatin binding of Mrc1 and favor DNA replication and S-phase checkpoint fork arrest. In the process of adaptation to the presence of hydroxyurea Mrc1 is detached from chromatin and Rad53 checkpoint activity is diminished in order to allow S-phase checkpoint escape and completion of the cell cycle. PMID:25379053

The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence.

PubMed

Uzunova, Sonya Dimitrova; Zarkov, Alexander Stefanov; Ivanova, Anna Marianova; Stoynov, Stoyno Stefanov; Nedelcheva-Veleva, Marina Nedelcheva

2014-01-01

The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM helicase when DNA synthesis is prohibited. Keeping the replication machinery intact allows restart of the replication fork when the block is relieved. Although the subunits of the Tof1/Csm3/Mrc1 complex are well studied, the impact of every single subunit on the triple complex formation and function needs to be established. This work studies the cellular localization and the chromatin binding of GFP-tagged subunits when the complex is intact and when a subunit is missing. We demonstrate that the complex is formed in cell nucleus, not the cytoplasm, as Tof1, Csm3 and Mrc1 enter the nucleus independently from one another. Via in situ chromatin binding assay we show that a Tof1-Csm3 dimer formation and chromatin binding is required to ensure the attachment of Mrc1 to chromatin. Our study indicates that the translocation into the nucleus is not the process to regulate the timing of chromatin association of Mrc1. We also studied the nuclear behavior of Mrc1 subunit in the process of adaptation to the presence hydroxyurea. Our results indicate that after prolonged HU incubation, cells bypass the S-phase checkpoint and proceed throughout the cell cycle. This process is accompanied by Mrc1 chromatin detachment and Rad53 dephosphorylation. In S. cerevisiae the subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3 independently enter the cell nucleus, where a Tof1-Csm3 dimer is formed to ensure the chromatin binding of Mrc1 and favor DNA replication and S-phase checkpoint fork arrest. In the process of adaptation to the presence of hydroxyurea Mrc1 is detached from chromatin and Rad53 checkpoint activity is diminished in order to allow S-phase checkpoint escape and completion of the cell cycle.

Heterogeneous CPA sensitivity of spontaneous excitation in smooth muscle of the rabbit urethra.

PubMed

Hashitani, Hikaru; Yanai, Yoshimasa; Kohri, Kenjiro; Suzuki, Hikaru

2006-06-01

1. To investigate the role of intracellular Ca stores in generating spontaneous excitation of the urethra, the effects of cyclopiazonic acid (CPA) on spontaneous contractions, transient increases in intracellular calcium concentration ([Ca2+]i; Ca transients) and depolarizations were examined in smooth muscles of the rabbit urethra. 2. In about 90% of circular smooth muscle (CSM) preparations, CPA (10 microM) increased the amplitude of spontaneous contractions by about 180% and reduced their frequency to some 25% of control values (CPA-resistant), while it readily abolished the contractions in the remaining preparations. 3. In about 70% of CSM preparations, CPA prevented the generation of spontaneous depolarizations termed slow waves, but increased their amplitude and duration in the remainder. CPA also prevented the generation of spontaneous Ca transients in about 40% of CSM preparations, while increasing their amplitude and duration in the remaining preparations. In CPA-resistant preparations that had been exposed to nicardipine (1 microM), subsequent CPA invariably abolished residual spontaneous depolarizations or Ca transients. CPA abolished caffeine-induced Ca transients in Ca-free solutions, suggesting that it effectively depleted intracellular Ca stores. 4. Longitudinal smooth muscles generated spontaneous action potentials, which had a shape distinct from that of slow waves in CSM. Spontaneous action potentials were abolished by nicardipine but not CPA. 5. Transmural nerve stimulation increased the frequency of Ca transients to give a sustained rise in [Ca2+]i, but inhibited their generation after blocking alpha-adrenoceptors with phentolamine (1 microM). These nerve-evoked responses were preserved in preparations that had been exposed to CPA. Similarly, both in control and CPA-treated CSM preparations, spontaneous Ca transients were accelerated by noradrenaline (NAd, 1 microM) and were suppressed by 3-morpholino-sydnonimine (SIN-1, 10 microM), a nitric oxide (NO) donor. 6. In conclusion, CSM of the urethra generates spontaneous activity, which depends on Ca release from intracellular Ca stores. However, after blocking this primary pacemaking mechanism, L-type Ca channel-dependent action potentials may drive CSM. Irrespective of the origin of pacemaking, neurally-released NAd and NO are capable of modulating spontaneous excitation.

SN 2010j1: Optical to Hard X-Ray Observations Reveal an Explosion Embedded in a Ten Solar Mass Cocoon

NASA Technical Reports Server (NTRS)

Ofek, Eran; Zoglauer, Andreas; Boggs, Steven E.; Barriere, Nicolas M.; Reynolds, Stephen P.; Fryer, Chris L.; Harrison, Fiona A.; Cenko, S. Bradley; Kulkarni, Shrinivas R.; Zhang, William W.;

Size-resolved characterization of the polysaccharidic and proteinaceous components of sea spray aerosol

NASA Astrophysics Data System (ADS)

Aller, Josephine Y.; Radway, JoAnn C.; Kilthau, Wendy P.; Bothe, Dylan W.; Wilson, Theodore W.; Vaillancourt, Robert D.; Quinn, Patricia K.; Coffman, Derek J.; Murray, Benjamin J.; Knopf, Daniel A.

2017-04-01

Dissolved organic polymers released by phytoplankton and bacteria abiologically self-assemble in surface ocean waters into nano-to micro-sized gels containing polysaccharides, proteins, lipids and other components. These gels concentrate in the sea surface microlayer (SML), where they can potentially contribute to sea spray aerosol (SSA). Sea spray is a major source of atmospheric aerosol mass over much of the earth's surface, and knowledge of its properties (including the amount and nature of the organic content), size distributions and fluxes are fundamental for determining its role in atmospheric chemistry and climate. Using a cascade impactor, we collected size-fractionated aerosol particles from ambient air and from freshly generated Sea Sweep SSA in the western North Atlantic Ocean together with biological and chemical characterization of subsurface and SML waters. Spectrophotometric methods were applied to quantify the polysaccharide-containing transparent exopolymer (TEP) and protein-containing Coomassie stainable material (CSM) in these particles and waters. This study demonstrates that both TEP and CSM in surface ocean waters are aerosolized with sea spray with the greatest total TEP associated with particles <180 nm in diameter and >5 000 nm. The higher concentrations of TEP and CSM in particles >5 000 nm most likely reflects collection of microorganism cells and/or fragments. The greater concentration of CSM in larger size particles may also reflect greater stability of proteinaceous gels compared to polysaccharide-rich gels in surface waters and the SML. Both TEP and CSM were measured in the ambient marine air sample with concentrations of 2.1 ± 0.16 μg xanthan gum equivalents (XG eq.) m-3 and 14 ± 1.0 μg bovine serum albumin equivalents (BSA eq.) m-3. TEP in Sea Sweep SSA averaged 4.7 ± 3.1 μg XG eq. m-3 and CSM 8.6 ± 7.3 μg BSA eq. m-3. This work shows the transport of marine biogenic material across the air-sea interface through primary particle emission and the first demonstration of particle size discriminated TEP and CSM characterization of SSA and ambient aerosol under field conditions.

Apollo 10 Command/Service Modules seen from Lunar Module after separation

NASA Image and Video Library

1969-05-22

AS10-27-3873 (22 May 1969) --- The Apollo 10 Command and Service Modules (CSM) are photographed from the Lunar Module (LM) after CSM/LM separation in lunar orbit. The CSM was about 175 statute miles east of Smyth's Sea and was above the rough terrain which is typical of the lunar far side. The eastward oblique view of the lunar surface is centered near 105 degrees east longitude and 1 degree north latitude. The horizon is approximately 600 kilometers (374 statute miles) away. Numerous bright craters and the absence of shadows show that the sun was almost directly overhead when this photograph was taken.

SAMPLING PROTOCOLS TO SUPPORT CLEANUP DECISIONS FOR CONTAMINANTS IN GROUND WATER

EPA Science Inventory

The ability to make reliable decisions about the extent of subsurface contamination and approaches to restoration of contaminated ground water is dependent on the development of an accurate conceptual site model (CSM). The accuracy of the CSM is dependent on the quality of site ...

Supernova spectra below strong circumstellar interaction

NASA Astrophysics Data System (ADS)

Leloudas, G.; Hsiao, E. Y.; Johansson, J.; Maeda, K.; Moriya, T. J.; Nordin, J.; Petrushevska, T.; Silverman, J. M.; Sollerman, J.; Stritzinger, M. D.; Taddia, F.; Xu, D.

2015-02-01

We construct spectra of supernovae (SNe) interacting strongly with a circumstellar medium (CSM) by adding SN templates, a black-body continuum, and an emission-line spectrum. In a Monte Carlo simulation we vary a large number of parameters, such as the SN type, brightness and phase, the strength of the CSM interaction, the extinction, and the signal to noise ratio (S/N) of the observed spectrum. We generate more than 800 spectra, distribute them to ten different human classifiers, and study how the different simulation parameters affect the appearance of the spectra and their classification. The SNe IIn showing some structure over the continuum were characterized as "SNe IInS" to allow for a better quantification. We demonstrate that the flux ratio of the underlying SN to the continuum fV is the single most important parameter determining whether a spectrum can be classified correctly. Other parameters, such as extinction, S/N, and the width and strength of the emission lines, do not play a significant role. Thermonuclear SNe get progressively classified as Ia-CSM, IInS, and IIn as fV decreases. The transition between Ia-CSM and IInS occurs at fV ~ 0.2-0.3. It is therefore possible to determine that SNe Ia-CSM are found at the (un-extincted) magnitude range -19.5 >M> -21.6, in very good agreement with observations, and that the faintest SN IIn that can hide a SN Ia has M = -20.1. The literature sample of SNe Ia-CSM shows an association with 91T-like SNe Ia. Our experiment does not support that this association can be attributed to a luminosity bias (91T-like being brighter than normal events). We therefore conclude that this association has real physical origins and we propose that 91T-like explosions result from single degenerate progenitors that are responsible for the CSM. Despite the spectroscopic similarities between SNe Ibc and SNe Ia, the number of misclassifications between these types was very small in our simulation and mostly at low S/N. Combined with the SN luminosity function needed to reproduce the observed SN Ia-CSM luminosities, it is unlikely that SNe Ibc constitute an important contaminant within this sample. We show how Type II spectra transition to IIn and how the Hα profiles vary with fV. SNe IIn fainter than M = -17.2 are unable to mask SNe IIP brighter than M = -15. A more advanced simulation, including radiative transfer, shows that our simplified model is a good first order approximation. The spectra obtained are in good agreement with real data.

Experimental statistics for biological sciences.

PubMed

Bang, Heejung; Davidian, Marie

2010-01-01

In this chapter, we cover basic and fundamental principles and methods in statistics - from "What are Data and Statistics?" to "ANOVA and linear regression," which are the basis of any statistical thinking and undertaking. Readers can easily find the selected topics in most introductory statistics textbooks, but we have tried to assemble and structure them in a succinct and reader-friendly manner in a stand-alone chapter. This text has long been used in real classroom settings for both undergraduate and graduate students who do or do not major in statistical sciences. We hope that from this chapter, readers would understand the key statistical concepts and terminologies, how to design a study (experimental or observational), how to analyze the data (e.g., describe the data and/or estimate the parameter(s) and make inference), and how to interpret the results. This text would be most useful if it is used as a supplemental material, while the readers take their own statistical courses or it would serve as a great reference text associated with a manual for any statistical software as a self-teaching guide.

CSM parallel structural methods research

NASA Technical Reports Server (NTRS)

Storaasli, Olaf O.

1989-01-01

Parallel structural methods, research team activities, advanced architecture computers for parallel computational structural mechanics (CSM) research, the FLEX/32 multicomputer, a parallel structural analyses testbed, blade-stiffened aluminum panel with a circular cutout and the dynamic characteristics of a 60 meter, 54-bay, 3-longeron deployable truss beam are among the topics discussed.

Is there a difference in range of motion, neck pain, and outcomes in patients with ossification of posterior longitudinal ligament versus those with cervical spondylosis, treated with plated laminoplasty?

PubMed

Fujimori, Takahito; Le, Hai; Ziewacz, John E; Chou, Dean; Mummaneni, Praveen V

2013-07-01

There are little data on the effects of plated, or plate-only, open-door laminoplasty on cervical range of motion (ROM), neck pain, and clinical outcomes. The purpose of this study was to compare ROM after a plated laminoplasty in patients with ossification of posterior longitudinal ligament (OPLL) versus those with cervical spondylotic myelopathy (CSM) and to correlate ROM with postoperative neck pain and neurological outcomes. The authors retrospectively compared patients with a diagnosis of cervical stenosis due to either OPLL or CSM who had been treated with plated laminoplasty in the period from 2007 to 2012 at the University of California, San Francisco. Clinical outcomes were measured using the modified Japanese Orthopaedic Association (mJOA) scale and neck visual analog scale (VAS). Radiographic outcomes included assessment of changes in the C2-7 Cobb angle at flexion and extension, ROM at C2-7, and ROM of proximal and distal segments adjacent to the plated lamina. Sixty patients (40 men and 20 women) with an average age of 63.1 ± 10.9 years were included in the study. Forty-one patients had degenerative CSM and 19 patients had OPLL. The mean follow-up period was 20.9 ± 13.1 months. The mean mJOA score significantly improved in both the CSM and the OPLL groups (12.8 to 14.5, p < 0.01; and 13.2 to 14.2, respectively; p = 0.04). In the CSM group, the mean VAS neck score significantly improved from 4.2 to 2.6 after surgery (p = 0.01), but this improvement did not reach the minimum clinically important difference (MCID). Neither was there significant improvement in the VAS neck score in the OPLL group (3.6 to 3.1, p = 0.17). In the CSM group, ROM at C2-7 significantly decreased from 32.7° before surgery to 24.4° after surgery (p < 0.01). In the OPLL group, ROM at C2-7 significantly decreased from 34.4° to 20.8° (p < 0.01). In the CSM group, the change in the VAS neck score significantly correlated with the change in the flexion angle (r = - 0.31) and the extension angle (r = - 0.37); however, it did not correlate with the change in ROM at C2-7 (r = - 0.1). In the OPLL group, the change in the VAS neck score did not correlate with the change in the flexion angle (r = 0.03), the extension angle (r = - 0.17), or the ROM at C2-7 (r = - 0.28). The OPLL group had a significantly greater loss of ROM after surgery than did the CSM group (p = 0.04). There was no significant correlation between the change in ROM and the mJOA score in either group. Plated laminoplasty in patients with either OPLL or CSM decreases cervical ROM, especially in the extension angle. Among patients who have undergone laminoplasty, those with OPLL lose more ROM than do those with CSM. No correlation was observed between neck pain and ROM in either group. Neither group had a change in neck pain that reached the MCID following laminoplasty. Both groups improved in neurological function and outcomes.

Physics of the Space Environment

NASA Astrophysics Data System (ADS)

Vasyliünas, Vytenis M.

This book, one in the Cambridge Atmospheric and Space Science Series, joins a growing list of advanced-level textbooks in a field of study and research known under a variety of names: space plasma physics, solar-terrestrial or solar-planetary relations, space weather, or (the official name of the relevant AGU section) space physics and aeronomy. On the basis of graduate courses taught by the author in various departments at the University of Michigan, complete with problems and with appendices of physical constants and mathematical identities, this is indeed a textbook, systematic and severe in its approach. The book is divided into three parts, in length ratios of roughly 6:4:5. Part I, “Theoretical Description of Gases and Plasmas,” starts by writing down Maxwell's equations and the Lorentz transformation (no nonsense about any introductory material of a descriptive or historical nature) and proceeds through particle orbit theory, kinetics, and plasma physics with fluid and MHD approximations to waves, shocks, and energetic particle transport. Part II, “The Upper Atmosphere,” features chapters on the terrestrial upper atmosphere, airglow and aurora, and the ionosphere. Part III, “Sun-Earth Connection,” deals with the Sun, the solar wind, cosmic rays, and the terrestrial magnetosphere. The book thus covers, with two exceptions, just about all the topics of interest to Space Physics and Aeronomy scientists, and then some (the chapter on the Sun, for instance, briefly discusses also topics of the solar interior: thermonuclear energy generation, equilibrium structure, energy transfer, with a page or two on each). One exception reflects a strong geocentric bias: there is not one word in the main text on magnetospheres and ionospheres of other planets and their interaction with the solar wind (they are mentioned in a few problems). The other exception: the chapter on the terrestrial magnetosphere lacks a systematic exposition of the theory of magnetosphereionosphere coupling.

NASA Systems Engineering Handbook

NASA Technical Reports Server (NTRS)

Hirshorn, Steven R.; Voss, Linda D.; Bromley, Linda K.

2017-01-01

The update of this handbook continues the methodology of the previous revision: a top-down compatibility with higher level Agency policy and a bottom-up infusion of guidance from the NASA practitioners in the field. This approach provides the opportunity to obtain best practices from across NASA and bridge the information to the established NASA systems engineering processes and to communicate principles of good practice as well as alternative approaches rather than specify a particular way to accomplish a task. The result embodied in this handbook is a top-level implementation approach on the practice of systems engineering unique to NASA. Material used for updating this handbook has been drawn from many sources, including NPRs, Center systems engineering handbooks and processes, other Agency best practices, and external systems engineering textbooks and guides. This handbook consists of six chapters: (1) an introduction, (2) a systems engineering fundamentals discussion, (3) the NASA program project life cycles, (4) systems engineering processes to get from a concept to a design, (5) systems engineering processes to get from a design to a final product, and (6) crosscutting management processes in systems engineering. The chapters are supplemented by appendices that provide outlines, examples, and further information to illustrate topics in the chapters. The handbook makes extensive use of boxes and figures to define, refine, illustrate, and extend concepts in the chapters.

NCAR CSM ocean model by the NCAR oceanography section. Technical note

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This technical note documents the ocean component of the NCAR Climate System Model (CSM). The ocean code has been developed from the Modular Ocean Model (version 1.1) which was developed and maintained at the NOAA Geophysical Fluid Dynamics Laboratory in Princeton. As a tribute to Mike Cox, and because the material is still relevant, the first four sections of this technical note are a straight reproduction from the GFDL Technical Report that Mike wrote in 1984. The remaining sections document how the NCAR Oceanography Section members have developed the MOM 1.1 code, and how it is forced, in order tomore » produce the NCAR CSM Ocean Model.« less

View of the Apollo 16 Command/Service Module from the Lunar module in orbit

NASA Image and Video Library

1971-04-20

AS16-113-18282 (23 April 1972) --- The Apollo Command and Service Modules (CSM) "Casper" approaches the Lunar Module (LM) "Orion", from which this photograph was made. The two spacecraft are about to make their final rendezvous of the mission, on April 23, 1972. Astronauts John W. Young, commander, and Charles M. Duke Jr., lunar module pilot, aboard the LM, were returning to the CSM, in lunar orbit, after three successful days on the lunar surface. Astronaut Thomas K. (Ken) Mattingly II, command module pilot, remained with the CSM in lunar orbit, while Young and Duke descended in the LM to explore the Descartes region of the moon.

Pseudohistory and Pseudoscience

NASA Astrophysics Data System (ADS)

Allchin, Douglas

The dangers of pseudoscience - parapsychology, astrology, creationism, etc. - are widely criticized. Lessons in the history of science are often viewed as an educational remedy by conveying the nature of science. But such histories can be flawed. In particular, many stories romanticize scientists, inflate the drama of their discoveries, and oversimplify the process of science. They are, literally and rhetorically, myths. While based on real historical events, they distort the basis of scientific authority and foster unwarranted stereotypes. Such stories are pseudohistory. Like pseudoscience, they promote false ideas about science - in this case, about how science works. Paradoxically, perhaps, the history of pseudosciences may offer an excellent vehicle for remedying such impressions. Characteristically, textbooks of science contain just a bit of history, either in an introductory chapter or, more often, in scattered references to the great heroes of an earlier age. From such references both students and professionals come to feel like participants in a long-standing historical tradition. Yet the textbook-derived tradition in which scientists come to sense their participation is one that, in fact, never existed.

SAMPLING PROTOCOLS TO SUPPORT DEVELOPMENT OF CONCEPTUAL SITE MODELS AND CLEANUP DECISIONS FOR CONTAMINANTS IN GROUND WATER

EPA Science Inventory

The ability to make reliable decisions about the extent of subsurface contamination and approaches to restoration of contaminated ground water is dependent on the development of an accurate conceptual site model (CSM). The accuracy of the CSM is dependent on the quality of site ...

Evaluation of the Correlated Science and Mathematics Professional Development Model, 2009-2010 Cohort

ERIC Educational Resources Information Center

Morlier, Rebecca

2012-01-01

The purpose of this paper is to evaluate the effectiveness of the 2009-2010 iteration of the Correlated Science and Mathematics (CSM) professional development program which provides teachers and principals experience with integrated and effective science and mathematics teaching strategies and content. Archival CSM data was analyzed via mixed…

Case Study: Collaborative Creation of an On-Line Degree Program

ERIC Educational Resources Information Center

Stewart, Barbara L.; Norwood, Marcella; Ezell, Shirley; Waight, Consuelo

2006-01-01

Faculty collaboratively developed an on-line Bachelor of Science degree in Consumer Science and Merchandising (CSM). Part-time faculty and technical support services supported the four-member team. Small grants assisted in the creation and redesign of all CSM major courses for on-line delivery. Issues of appropriate learning strategies, student…

Defending commercial surrogate motherhood against Van Niekerk and Van Zyl.

PubMed Central

McLachlan, H V

1997-01-01

The arguments of Van Niekerk and Van Zyl that, on the grounds that it involves an inappropriate commodification and alienation of women's labour, commercial surrogate motherhood (CSM) is morally suspect are discussed and considered to be defective. In addition, doubt is cast on the notion that CSM should be illegal. PMID:9451602

Decision validity should determine whether a generic or condition-specific HRQOL measure is used in health care decisions.

PubMed

Dowie, Jack

2002-01-01

When a HRQOL measure is needed in health care decision making should it be a generic measure (a GEN), intended to cover the entire domain of health, a condition-specific measure (a CSM) intended to embrace those aspects of health associated with the condition concerned, or both? This paper proposes that it will never be appropriate to use both a CSM and a GEN for the same decision; that a GEN alone will probably be the appropriate measure in the majority of decisions; that a CSM alone will sometimes be appropriate; and that whether it is a GEN alone or a CSM alone that is appropriate depends entirely on the structure of the decision. The argument rests on the distinction between knowledge validity and decision validity. But it has a supplementary basis in rejection of the widespread (but unjustifiable) belief that CSMs are more "sensitive" or "responsive" than GENs and hence can detect "small but important changes" that GENs always or often miss. Copyright 2002 John Wiley & Sons, Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Higuchi, T.

A textbook containing 22 chapters by various authors covers the structure of wood, the localization of polysaccharides and lignins in wood cell walls, metabolism and synthetic function of cambial tissue, cell organelles and their function in the biosynthesis of cell wall components, biosynthesis of plant cell wall polysaccharides, lignin, cutin, suberin and associated waxes, phenolic acids and monolignols, quinones, flavonoids, tannins, stilbenes and terpenoid wood extractives, the occurrence of extractives, the metabolism of phenolic acids, wood degradation by micro-organisms and fungi, and biodegradation of cellulose, hemicelluloses, lignin, and aromatic extractives of wood. An index is included.

Medical genetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jorde, L.B.; Carey, J.C.; White, R.L.

This book on the subject of medical genetics is a textbook aimed at a very broad audience: principally, medical students, nursing students, graduate, and undergraduate students. The book is actually a primer of general genetics as applied to humans and provides a well-balanced introduction to the scientific and clinical basis of human genetics. The twelve chapters include: Introduction, Basic Cell Biology, Genetic Variation, Autosomal Dominant and Recessive Inheritance, Sex-linked and Mitochondrial Inheritance, Clinical Cytogenetics, Gene Mapping, Immunogenetics, Cancer Genetics, Multifactorial Inheritance and Common Disease, Genetic Screening, Genetic Diagnosis and Gene Therapy, and Clinical Genetics and Genetic Counseling.

Mid-Infrared Signatures from Type Ia Supernovae Strongly Interacting with a Circumstellar Medium

NASA Astrophysics Data System (ADS)

Fox, Ori

2015-10-01

Type Ia supernovae (SNe Ia) are well-known for their use as precise cosmological distance indicators due to a standardizable peak luminosity resulting from a thermonuclear explosion. A growing subset of SNe Ia, however, show evidence for interaction with a dense circumstellar medium during the first year post-explosion, and sometimes longer (SNe Ia-CSM). The origin of this dense CSM is unknown and suggests either a) the less typical single-degenerate progenitor scenario must be considered or b) the exploding star was not a thermonuclear explosion of a white dwarf at all (i.e., core-collapse). Mid-infrared (IR) observations, in particular, are critical for tracing the density profile of dust (and hence gas) in the surrounding CSM. Yet no Spitzer light curve exists for this subclass within the first year post-expolosion. Here we propose a 'low-impact' (>8 weeks) ToO to obtain 3 epochs of Spitzer imaging of a SN Ia-CSM within 100 Mpc over 1 year post-explosion. The strength of this program is that it will be in conjunction with pre-approved multi-wavelength programs on HST/STIS/UV (GO 13649), Chandra/ASIS-S (Num: 17500672), the Keck/LRIS optical spectrograph (Num: U037LA), and the RATIR visible/infrared robotic imager. Requiring only 2.1 hours of observation total, this program will not only distinguish between the SN explosion mechanisms, but also trace CSM interaction, constrain the progenitor mass loss history, and identify late-time heating mechanisms of warm dust.

A Bayesian belief network approach for assessing uncertainty in conceptual site models at contaminated sites

NASA Astrophysics Data System (ADS)

Thomsen, Nanna I.; Binning, Philip J.; McKnight, Ursula S.; Tuxen, Nina; Bjerg, Poul L.; Troldborg, Mads

2016-05-01

A key component in risk assessment of contaminated sites is in the formulation of a conceptual site model (CSM). A CSM is a simplified representation of reality and forms the basis for the mathematical modeling of contaminant fate and transport at the site. The CSM should therefore identify the most important site-specific features and processes that may affect the contaminant transport behavior at the site. However, the development of a CSM will always be associated with uncertainties due to limited data and lack of understanding of the site conditions. CSM uncertainty is often found to be a major source of model error and it should therefore be accounted for when evaluating uncertainties in risk assessments. We present a Bayesian belief network (BBN) approach for constructing CSMs and assessing their uncertainty at contaminated sites. BBNs are graphical probabilistic models that are effective for integrating quantitative and qualitative information, and thus can strengthen decisions when empirical data are lacking. The proposed BBN approach facilitates a systematic construction of multiple CSMs, and then determines the belief in each CSM using a variety of data types and/or expert opinion at different knowledge levels. The developed BBNs combine data from desktop studies and initial site investigations with expert opinion to assess which of the CSMs are more likely to reflect the actual site conditions. The method is demonstrated on a Danish field site, contaminated with chlorinated ethenes. Four different CSMs are developed by combining two contaminant source zone interpretations (presence or absence of a separate phase contamination) and two geological interpretations (fractured or unfractured clay till). The beliefs in each of the CSMs are assessed sequentially based on data from three investigation stages (a screening investigation, a more detailed investigation, and an expert consultation) to demonstrate that the belief can be updated as more information becomes available.

Competing-risks mortality after radiotherapy vs. observation for localized prostate cancer: a population-based study.

PubMed

Abdollah, Firas; Sun, Maxine; Schmitges, Jan; Thuret, Rodolphe; Tian, Zhe; Shariat, Shahrokh F; Briganti, Alberto; Jeldres, Claudio; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I

2012-09-01

Contemporary patients with localized prostate cancer (PCa) are more frequently treated with radiotherapy. However, there are limited data on the effect of this treatment on cancer-specific mortality (CSM). Our objective was to test the relationship between radiotherapy and survival in men with localized PCa and compare it with those treated with observation. A population-based cohort identified 68,797 men with cT1-T2 PCa treated with radiotherapy or observation between the years 1992 and 2005. Propensity-score matching was used to minimize potential bias related to treatment assignment. Competing-risks analyses tested the effect of treatment type (radiotherapy vs. observation) on CSM, after accounting to other-cause mortality. All analyses were carried out within PCa risk, baseline comorbidity status, and age groups. Radiotherapy was associated with more favorable 10-year CSM rates than observation in patients with high-risk PCa (8.8 vs. 14.4%, hazard ratio [HR]: 0.59, 95% confidence interval [CI]: 0.50-0.68). Conversely, the beneficial effect of radiotherapy on CSM was not evident in patients with low-intermediate risk PCa (3.7 vs. 4.1%, HR: 0.91, 95% CI: 0.80-1.04). Radiotherapy was beneficial in elderly patients (5.6 vs. 7.3%, HR: 0.70, 95% CI: 0.59-0.80). Moreover, it was associated with improved CSM rates among patients with no comorbidities (5.7 vs. 6.5%, HR: 0.81, 95% CI: 0.67-0.98), one comorbidity (4.6 vs. 6.0%, HR: 0.87, 95% CI: 0.75-0.99), and more than two comorbidities (4.2 vs. 5.0%, HR: 0.79, 95% CI: 0.65-0.96). Radiotherapy substantially improves CSM in patients with high-risk PCa, with little or no benefit in patients with low-/intermediate-risk PCa relative to observation. These findings must be interpreted within the context of the limitations of observational data. Copyright © 2012 Elsevier Inc. All rights reserved.

Comparison of Three Reconstructive Techniques in the Surgical Management of Patients With Four-Level Cervical Spondylotic Myelopathy.

PubMed

Li, Zhonghai; Wang, Huadong; Tang, Jiaguang; Ren, Dongfeng; Li, Li; Hou, Shuxun; Zhang, Hailong; Hou, Tiesheng

2017-05-15

Retrospective clinical series. To compare perioperative parameters, clinical outcomes, radiographic parameters, and complication rates of three reconstructive techniques after the anterior decompression of four-level cervical spondylotic myelopathy (CSM). At present, the decision to treat multilevel CSM, especially four-level CSM, remains controversial. No one compares multilevel anterior cervical discectomy and fusion (mACDF), segmental anterior cervical corpectomy and fusion (sACCF) to multilevel anterior cervical discectomy and fusion with cage alone (mACDF-CA) in four-level constructs. Between July 2006 and February 2014, 97 consecutive patients with four-level CSM were enrolled in this study and divided into sACCF (n = 39) group, mACDF (n = 31) group, and mACDF-CA (n = 27) group. The study compared perioperative parameters, complication rates, clinical and radiologic parameters of three reconstructive techniques after the anterior decompression of four-level CSM. The mACDF-CA group had the least bleeding and cost of index surgery compared with the sACCF group having the most bleeding and cost. Although significant pain relief and functional activity improvement have been achieved in the three groups at the final follow-up, there was no significant difference in the Japanese Orthopedic Association, SF-36 and NDI scores among the three groups (P >0.05). The mACDF group maintained the best cervical lordosis at the final follow-up, compared with the sACCF group maintained the worst cervical lordosis. Solid fusion was achieved in 87.1% of subjects in sACCF group, 90.3% in mACDF, and in 88.9% in mACDF-CA. The mACDF-CA group had a higher rate of subsidence and lower rate of dysphagia than other two groups. mACDF-CA can be considered an effective and safe alternative procedure in the treatment of the four-level CSM. 4.

Abrupt appearance of shocked quartz at the Cretaceous-Tertiary boundary, Raton Basin, Colorado and New Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Izett, G.A.; Pillmore, C.L.

1985-01-01

Unique quartz grains as large as 0.5 mm and having up to 6 sets of closely spaced microfractures (CSM) occur at the palynological K-T boundary at 9 scattered sites from Trinidad, Colorado, south 50 km to Raton, New Mexico. Similar quartz grains at the K-T boundary in Montana and Europe were ascribed a shock-metamorphic origin by B. Bohor and colleagues in 1984-85. In the Raton Basin, quartz grains with CSM are concentrated at the top and base of a 2.5-cm-tick kaolinite bed in a nonmarine sequence of somber-colored sandstone, siltstone, shale, and coal. No quartz grains with CSM have yetmore » been found below the K-T bed in the Raton Basin, but a few have been found about 25 cm below the K-T bed at Brownie Butte, Montana. Most quartz grains having CSM are single optical units, but some are compound grains showing sutured boundaries (metaquartzite). Nearly all quartz grains with CSM have refractive indices and birefringence normal for quartz which suggests they formed at not more than 100 kb (low shock); however, a few have n/sub 0/ lowered to 1.538, but have normal birefringence. About half of 100 measured CSM in quartz make an angle of 15-25 degrees with the base (0001). The K-T kaolinite bed in the Raton Basin contains anomalously large amounts of Ir and is possibly coeval with marine, Ir-bearing K-T claystone beds in Europe described in 1980 by W. Alvarez and his associated who suggested they formed when a large bolide struck the Earth causing mass extinction of certain animals and plants. The shocked quartz and metaquartzite at the K-T boundary is compelling evidence that a bolide struck an onland-area of quartz-rich crustal rocks--not in an ocean.« less

Are bowel purgatives and prokinetics useful for small-bowel capsule endoscopy? A prospective randomized controlled study.

PubMed

Postgate, Aymer; Tekkis, Paris; Patterson, Neil; Fitzpatrick, Aine; Bassett, Paul; Fraser, Chris

2009-05-01

Capsule endoscopy (CE) is limited by incomplete small-bowel transit and poor view quality in the distal bowel. Currently, there is no consensus regarding the use of bowel purgatives or prokinetics in CE. To evaluate the usefulness of bowel purgatives and prokinetics in small-bowel CE. Prospective single-blind randomized controlled study. Academic endoscopy unit. A total of 150 patients prospectively recruited. Patients were randomized to 1 of 4 preparations: "standard" (fluid restriction then nothing by mouth 12 hours before the procedure, water and simethicone at capsule ingestion [S]); "standard" + 10 mg oral metoclopramide before the procedure (M); Citramag + senna bowel-purgative regimen the evening before CE (CS); Citramag + senna + 10 mg metoclopramide before the procedure (CSM). Gastric transit time (GTT) and small-bowel transit time (SBTT), completion rates (CR), view quality, and patient acceptability. positive findings, diagnostic yield. No significant difference was noted among groups for GTT (median [minutes] M, CS, and CSM vs S: 17.3, 24.7, and 15.1 minutes vs 16.8 minutes, respectively; P = .62, .18, and .30, respectively), SBTT (median [minutes] M, CS, and CSM vs S: 260, 241, and 201 vs 278, respectively; P = .91, .81, and .32, respectively), or CRs (85%, 85%, and 88% vs 89% for M, CS, and CSM vs S, respectively; P = .74, .74, and 1.00, respectively). There was no significant difference in view quality among groups (of 44: 38, 37, and 40 vs 37 for M, CS, and CSM, vs S, respectively; P = .18, .62, and .12, respectively). Diagnostic yield was similar among the groups. CS and CSM regimens were significantly less convenient (P < .001), and CS was significantly less comfortable (P = .001) than standard preparation. Bowel purgatives and prokinetics do not improve CRs or view quality at CE, and bowel purgatives reduce patient acceptability.

Magnetic resonance diffusion tensor imaging of cervical spinal cord and lumbosacral enlargement in patients with cervical spondylotic myelopathy.

PubMed

Chen, Xueming; Kong, Chao; Feng, Shiqing; Guan, Hua; Yu, Zhenshan; Cui, Libin; Wang, Yanhui

2016-06-01

To identify the correlations of diffusion tensor imaging (DTI) indices between the cervical spinal cord and lumbosacral enlargement in healthy volunteers and patients with cervical spondylotic myelopathy (CSM). DTI was performed at the cervical spinal cord and lumbosacral enlargement in 10 CSM patients and 10 volunteers at 1.5T. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of were measured and compared between CSM patients and volunteers. DTI indices of different cervical segments in volunteers were compared. DTI indices of the cervical spinal cord were correlated with those of the lumbosacral enlargement. In healthy subjects, DTI indices of different cervical cord sections showed no significant difference (ADC: F = 0.62; P = 0.65; FA: F = 1.228; P = 0.312); there was no correlation between the DTI indices of the cervical spinal cord and those of the lumbosacral enlargement (ADC: r = 0.442, P = 0.201; FA: r = -0.054, P = 0.881). In the CSM patients, the ADC value significantly increased, while the FA value significantly decreased in the cervical spinal cord (ADC: P = 0.002; FA: P < 0.001) and lumbosacral enlargement (ADC: P = 0.003; FA: P < 0.001) compared with the healthy group. Both DTI indices showed no correlation between the cervical spinal cord and those of the lumbosacral enlargement in the CSM group (ADC: r = -0.052, P = 0.887; FA: r = 0.129, P = 0.722). The ADC value of the cervical spinal cord and lumbosacral enlargement in CSM patients showed significant increase compared with healthy volunteers, while the FA value significantly decreased. Both DTI indices of the cervical spinal cord had no linear correlation with those of the lumbosacral enlargement. J. Magn. Reson. Imaging 2016;43:1484-1491. © 2015 Wiley Periodicals, Inc.

SU-G-TeP1-08: LINAC Head Geometry Modeling for Cyber Knife System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, B; Li, Y; Liu, B

Purpose: Knowledge of the LINAC head information is critical for model based dose calculation algorithms. However, the geometries are difficult to measure precisely. The purpose of this study is to develop linac head models for Cyber Knife system (CKS). Methods: For CKS, the commissioning data were measured in water at 800mm SAD. The measured full width at half maximum (FWHM) for each cone was found greater than the nominal value, this was further confirmed by additional film measurement in air. Diameter correction, cone shift and source shift models (DCM, CSM and SSM) are proposed to account for the differences. Inmore » DCM, a cone-specific correction is applied. For CSM and SSM, a single shift is applied to the cone or source physical position. All three models were validated with an in-house developed pencil beam dose calculation algorithm, and further evaluated by the collimator scatter factor (Sc) correction. Results: The mean square error (MSE) between nominal diameter and the FWHM derived from commissioning data and in-air measurement are 0.54mm and 0.44mm, with the discrepancy increasing with cone size. Optimal shift for CSM and SSM is found to be 9mm upward and 18mm downward, respectively. The MSE in FWHM is reduced to 0.04mm and 0.14mm for DCM and CSM (SSM). Both DCM and CSM result in the same set of Sc values. Combining all cones at SAD 600–1000mm, the average deviation from 1 in Sc of DCM (CSM) and SSM is 2.6% and 2.2%, and reduced to 0.9% and 0.7% for the cones with diameter greater than 15mm. Conclusion: We developed three geometrical models for CKS. All models can handle the discrepancy between vendor specifications and commissioning data. And SSM has the best performance for Sc correction. The study also validated that a point source can be used in CKS dose calculation algorithms.« less

Evaluating social marketing programs.

PubMed

1988-01-01

Contraceptive social marketing programs (CSM) which use commercial marketing techniques and distribution networks to sell contraceptives at subsidized prices, have become an important source of contraceptives in many developing countries. However, research is needed to determine the extent to which CSM programs are recruiting new users or simply serving as an alternate source for those who already use contraceptives. 1st begun in India in 1967, today CSM programs are selling contraceptives in more than 20 countries, mostly selling condoms because they do not require medical supervision or usually have to be registered with governments as a pharmaceutical product. Most also sell oral contraceptives. Advertising is used to promote the program, both brand and generic, about family planning and the advantages of small families. In some countries only generic promotion is permitted. A CSM program begins with research on the marketplace and needs of potential customers, including baseline studies, group discussions, and personal interviews. Monitoring is done by market research on usage, acceptability and adequacy of distribution. Focus groups and surveys are also used. Evaluation methodologies are similar to those used in program planning and monitoring, including consumer intercept surveys and tracking studies. Program impact is an area often neglected, probably because of the unusual relationship between the private and public sectors that occurs in CSM. Couple-years of protection is the common measurement of impact, estimated from sales data (13 cycles of pills or 100 condoms or doses of spermicide/year is assumed to prevent conception). This method can be used to assess the contributions of different methods and distribution systems and to compare their cost-effectiveness by calculating the cost per couple-year of protection provided. Limitations on this measurement method are inability to discriminate sporadic use from careful compliance; sales may be substitutes for obtaining contraceptives from other sources. Consumer-intercept surveys can distinguish "switchers" from users. National, household and census surveys can also have a few questions directly related to CSM and provide secondary data to measure program impact.

Dental chapters of Serefeddin Sabuncuoglu's (1385-1468?) illustrated surgical book Cerrahiyyetu'l Haniyye.

PubMed

Uzel, I

1997-11-01

From the 7th to the 11th centuries Arabic authors translated ancient Greek and Roman medical textbooks into their own languages. In the 11th and 12th centuries, noted authors used these early translations when writing other classical texts. One of these was that of the Andalusian surgeon, Albulcasis (936-1013), whose famous work is entitled, at-Tasrif (4,6). It has been used as a reference book for centuries and was translated into Latin in the 15th century and into Turkish by me when I discovered a manuscript of it in the Manisa Library in Turkey (14). The best interpreter of it, however, was Serefeddin Sabuncuoglu (1365-1468). He used the classification of at-Tasrif, but improved on it by adding original observations and three original chapters. His book is entitled, Cerrahiyyetu'l Haniyye which means The Imperial Surgery (15).

Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal*

PubMed Central

Zhang, Wen-ju; Xu, Zi-rong; Sun, Jian-yi; Yang, Xia

2006-01-01

The objective of this work was to investigate the effect of six individual strains of fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal (CSM). Six groups of disinfected CSM substrate were incubated for 48 h after inoculation with either of the fungi C. capsuligena ZD-1, C. tropicalis ZD-3, S. cerevisae ZD-5, A. terricola ZD-6, A. oryzae ZD-7, or A. niger ZD-8. One not inoculated group (substrate) was used as a control. Levels of initial and final free gossypol (FG), crude protein (CP), amino acids (AA) and in vitro digestibility were assayed. The experiment was done in triplicate. The experimental results indicated that microbial fermentation could greatly decrease (P<0.05) FG levels in CSM. The detoxification efficiency differed between the species of microorganisms applied. From the perspective of reducing CSM potential toxicity, C. tropicalis ZD-3 was most successful followed by S. cerevisae ZD-5 and A. niger ZD-8. They could reduce FG levels of CSM to 29.8, 63.07 and 81.50 mg/kg based on DM (dry matter), respectively, and their detoxification rates were 94.57%, 88.51% and 85.16%, respectively. If crude protein, amino acids content and their in vitro digestibility were also taken into account, A. niger ZD-8 may be the best choice. The CP content of CSM substrate fermented by C. tropicalis ZD-3 and A. niger ZD-8 were improved by 10.76% and 22.24%; the TAA (total amino acids) contents were increased by 7.06% and 11.46%, and the EAA (essential amino acids) were raised by 7.77% and 12.64%, respectively. Especially, the levels of methionine, lysine and threonine were improved greatly (P<0.05). The in vitro CP digestibility of CSM fermented by C. tropicalis ZD-3 and A. niger ZD-8 was improved by 13.42% and 18.22%, the TAA were increased by 17.75% and 22.88%, and the EAA by 16.61% and 21.01%, respectively. In addition, the in vitro digestibility of methionine, lysine and threonine was also improved greatly (P<0.05). PMID:16909468

Apollo Command and Service Module Propulsion Systems Overview

NASA Technical Reports Server (NTRS)

Interbartolo, Michael A.

2009-01-01

An overview of the Apollo Command and Service Module (CSM) propulsion systems is provided. The systems for CSM propulsion and control are defined, the times during the mission when each system is used are listed, and, the basic components and operation of the service propulsion system, SM reaction control system and CM reaction control system are described.

APOLLO-SATURN (A/S)-204 - SPACECRAFT (S/C)- 012 COMMAND SERVICE MODULE (CSM) - A/S MATING - CAPE

NASA Image and Video Library

1967-01-03

S67-15704 (3 Jan. 1967) --- Transfer of Apollo Spacecraft 012 Command/Service Module (CSM) for mating with the Saturn Lunar Module (LM) Adapter No.05 in the Manned Spacecraft Operations Building. Spacecraft 012 will be flown on the Apollo/Saturn 1 (204) mission. Photo credit: NASA

Overview of computational structural methods for modern military aircraft

NASA Technical Reports Server (NTRS)

Kudva, J. N.

1992-01-01

Computational structural methods are essential for designing modern military aircraft. This briefing deals with computational structural methods (CSM) currently used. First a brief summary of modern day aircraft structural design procedures is presented. Following this, several ongoing CSM related projects at Northrop are discussed. Finally, shortcomings in this area, future requirements, and summary remarks are given.

Level Density in the Complex Scaling Method

NASA Astrophysics Data System (ADS)

Suzuki, R.; Myo, T.; Katō, K.

2005-06-01

It is shown that the continuum level density (CLD) at unbound energies can be calculated with the complex scaling method (CSM), in which the energy spectra of bound states, resonances and continuum states are obtained in terms of L(2) basis functions. In this method, the extended completeness relation is applied to the calculation of the Green functions, and the continuum-state part is approximately expressed in terms of discretized complex scaled continuum solutions. The obtained result is compared with the CLD calculated exactly from the scattering phase shift. The discretization in the CSM is shown to give a very good description of continuum states. We discuss how the scattering phase shifts can inversely be calculated from the discretized CLD using a basis function technique in the CSM.

Nuclear Reactor Physics

NASA Astrophysics Data System (ADS)

Stacey, Weston M.

2001-02-01

An authoritative textbook and up-to-date professional's guide to basic and advanced principles and practices Nuclear reactors now account for a significant portion of the electrical power generated worldwide. At the same time, the past few decades have seen an ever-increasing number of industrial, medical, military, and research applications for nuclear reactors. Nuclear reactor physics is the core discipline of nuclear engineering, and as the first comprehensive textbook and reference on basic and advanced nuclear reactor physics to appear in a quarter century, this book fills a large gap in the professional literature. Nuclear Reactor Physics is a textbook for students new to the subject, for others who need a basic understanding of how nuclear reactors work, as well as for those who are, or wish to become, specialists in nuclear reactor physics and reactor physics computations. It is also a valuable resource for engineers responsible for the operation of nuclear reactors. Dr. Weston Stacey begins with clear presentations of the basic physical principles, nuclear data, and computational methodology needed to understand both the static and dynamic behaviors of nuclear reactors. This is followed by in-depth discussions of advanced concepts, including extensive treatment of neutron transport computational methods. As an aid to comprehension and quick mastery of computational skills, he provides numerous examples illustrating step-by-step procedures for performing the calculations described and chapter-end problems. Nuclear Reactor Physics is a useful textbook and working reference. It is an excellent self-teaching guide for research scientists, engineers, and technicians involved in industrial, research, and military applications of nuclear reactors, as well as government regulators who wish to increase their understanding of nuclear reactors.

A content analysis of physical science textbooks with regard to the nature of science and ethnic diversity

NASA Astrophysics Data System (ADS)

Brooks, Kristine M.

The goal of science education is the preparation of scientifically literate students (Abd-El-Khalick & Lederman, 2000, & American Association for the Advancement of Science (AAAS), 1990). In order to instruct students in the nature of science with its history, development, methods and applications, science teachers use textbooks as the primary organizer for the curriculum (Chippetta, Ganesh, Lee, & Phillips, 2006). Science textbooks are the dominant instructional tool that exerts great influence on instructional content and its delivery (Wang, 1998). Science and science literacy requires acquiring knowledge about the natural world and understanding its application in society, or, in other words, the nature of science. An understanding of the nature of science is an important part of science literacy (Abd-El-Khalik & Lederman, 2000, & AAAS, 1990). The nature of science has four basic themes or dimensions: science as a body of knowledge, science as a way of thinking, science as a way of investigating, and science with its interaction with technology and society (Chippetta & Koballa, 2006). Textbooks must relay and incorporate these themes to promote science literacy. The results from this content analysis provide further insights into science textbooks and their content with regard to the inclusion of the nature of science and ethnic diversity. Science textbooks usually downplay human influences (Clough & Olson, 2004) whether as part of the nature of science with its historical development or its interaction with societies of diverse cultures. Minority students are underperforming in science and science is divided on ethnic, linguistic, and gender identity (Brown, 2005). Greater representations of diversity in curriculum materials enable minority students to identify with science (Nines, 2000). Textbooks, with their influence on curriculum and presentation, must include links for science and students of diverse cultures. What is the balance of the four aspects of the nature of science and what is the balance of ethnic diversity in the participants in science (students and scientists) in physical science textbooks? To establish an answer to these questions, this investigation used content analysis. For the balance of the four aspects of the nature of science, the analysis was conducted on random page samples of five physical science textbooks. A random sampling of the pages within the physical science textbooks should be sufficient to represent the content of the textbooks (Garcia, 1985). For the balance of ethnic diversity of the participants in science, the analysis was conducted on all pictures or drawings of students and scientists within the content of the five textbooks. One of these IPC books is under current use in a large, local school district and the other four were published during the same, or similar, year. Coding procedures for the sample used two sets of coders. One set of coders have previously analyzed for the nature of science in a study on middle school science textbooks (Phillips, 2006) and the coders for ethnic diversity are public school teachers who have worked with ethnically diverse students for over ten years. Both sets of coders were trained and the reliability of their coding checked before coding the five textbooks. To check for inter-coder reliability, percent agreement, Cohen's kappa and Krippendorff's alpha were calculated. The results from this study indicate that science as a body of knowledge and science as a way of investigating are the prevalent themes of the nature of science in the five physical science textbooks. This investigation also found that there is an imbalance in the ethnic diversity of students and scientists portrayed within the chapters of the physical science textbooks studied. This imbalance reflects ratios that are neither equally balanced nor in align with the U.S. Census. Given that textbooks are the main sources of information in most classrooms, the imbalance of the nature of science could provide the students, and the teachers, with an incomplete perception and understanding of the nature of science. This imbalance could also provide the students with inadequate skills to develop and process science information and apply it to their world. The ethnic diversity portrayed in the physical science textbooks provides an inadequate link between the students' ethnic backgrounds and the ethnic diversity of the participants of science. Educators and publishers should provide science textbooks that incorporate all four aspects of the nature of science to a degree that science is perceived as more than just facts and information. Science must be recognized as a way of investigating, a way of thinking, and a way of applying knowledge to society. Further, in order to recognize all people who take part in science, students and scientists from a variety of ethnic groups should be portrayed in the physical science textbooks.

Rumen Degradability and Post-ruminal Digestion of Dry Matter, Nitrogen and Amino Acids of Three Protein Supplements.

PubMed

Gao, Wei; Chen, Aodong; Zhang, Bowen; Kong, Ping; Liu, Chenli; Zhao, Jie

2015-04-01

This study evaluated the in situ ruminal degradability, and subsequent small intestinal digestibility (SID) of dry matter, crude protein (CP), and amino acids (AA) of cottonseed meal (CSM), sunflower seed meal (SFSM) and distillers dried grains with solubles (DDGS) by using the modified three-step in vitro procedure. The ruminal degradability and subsequent SID of AA in rumen-undegradable protein (RUP-AA) varied among three protein supplements. The result show that the effective degradability of DM for SFSM, CSM, and DDGS was 60.8%, 56.4%, and 41.0% and their ruminal fermentable organic matter was 60.0%, 55.9%, and 39.9%, respectively. The ruminal degradable protein (RDP) content in CP for SFSM, CSM, and DDGS was 68.3%, 39.0%, and 32.9%, respectively, at the ruminal solid passage rate of 1.84%/h. The SFSM is a good source of RDP for rumen micro-organisms; however, the SID of RUP of SFSM was lower. The DDGS and CSM are good sources of RUP for lambs to digest in the small intestine to complement ruminal microbial AA of growing lambs. Individual RUP-AA from each protein source was selectively removed by the rumen micro-organisms, especially for Trp, Arg, His, and Lys (p<0.01). The SID of individual RUP-AA was different within specific RUP origin (p<0.01). Limiting amino acid was Leu for RUP of CSM and Lys for both RUP of SFSM and DDGS, respectively. Therefore, different protein supplements with specific limitations should be selected and combined carefully in growing lambs ration to optimize AA balance.

X-ray emission from SN 2012ca: A Type Ia-CSM supernova explosion in a dense surrounding medium

NASA Astrophysics Data System (ADS)

Bochenek, Christopher D.; Dwarkadas, Vikram V.; Silverman, Jeffrey M.; Fox, Ori D.; Chevalier, Roger A.; Smith, Nathan; Filippenko, Alexei V.

2018-01-01

X-ray emission is one of the signposts of circumstellar interaction in supernovae (SNe), but until now, it has been observed only in core-collapse SNe. The level of thermal X-ray emission is a direct measure of the density of the circumstellar medium (CSM), and the absence of X-ray emission from Type Ia SNe has been interpreted as a sign of a very low density CSM. In this paper, we report late-time (500-800 d after discovery) X-ray detections of SN 2012ca in Chandra data. The presence of hydrogen in the initial spectrum led to a classification of Type Ia-CSM, ostensibly making it the first SN Ia detected with X-rays. Our analysis of the X-ray data favours an asymmetric medium, with a high-density component which supplies the X-ray emission. The data suggest a number density >108 cm-3 in the higher density medium, which is consistent with the large observed Balmer decrement if it arises from collisional excitation. This is high compared to most core-collapse SNe, but it may be consistent with densities suggested for some Type IIn or superluminous SNe. If SN 2012ca is a thermonuclear SN, the large CSM density could imply clumps in the wind, or a dense torus or disc, consistent with the single-degenerate channel. A remote possibility for a core-degenerate channel involves a white dwarf merging with the degenerate core of an asymptotic giant branch star shortly before the explosion, leading to a common envelope around the SN.

Comparison of two statistical methods for probability prediction of monthly precipitation during summer over Huaihe River Basin in China, and applications in runoff prediction based on hydrological model

NASA Astrophysics Data System (ADS)

Liu, L.; Du, L.; Liao, Y.

2017-12-01

Based on the ensemble hindcast dataset of CSM1.1m by NCC, CMA, Bayesian merging models and a two-step statistical model are developed and employed to predict monthly grid/station precipitation in the Huaihe River China during summer at the lead-time of 1 to 3 months. The hindcast datasets span a period of 1991 to 2014. The skill of the two models is evaluated using area under the ROC curve (AUC) in a leave-one-out cross-validation framework, and is compared to the skill of CSM1.1m. CSM1.1m has highest skill for summer precipitation from April while lowest from May, and has highest skill for precipitation in June but lowest for precipitation in July. Compared with raw outputs of climate models, some schemes of the two approaches have higher skill for the prediction from March and May, but almost schemes have lower skill for prediction from April. Compared to two-step approach, one sampling scheme of Bayesian merging approach has higher skill for the prediction from March, but has lower skill from May. The results suggest that there is potential to apply the two statistical models for monthly precipitation forecast in summer from March and from May over Huaihe River basin, but is potential to apply CSM1.1m forecast from April. Finally, the summer runoff during 1991 to 2014 is simulated based on one hydrological model using the climate hindcast of CSM1.1m and the two statistical models.

Understanding surgery choices for breast cancer: how might the Theory of Planned Behaviour and the Common Sense Model contribute to decision support interventions?

PubMed Central

Sivell, Stephanie; Edwards, Adrian; Elwyn, Glyn; Manstead, Antony S. R.

2010-01-01

Abstract Objective  To describe the evidence about factors influencing breast cancer patients’ surgery choices and the implications for designing decision support in reference to an extended Theory of Planned Behaviour (TPB) and the Common Sense Model of Illness Representations (CSM). Background  A wide range of factors are known to influence the surgery choices of women diagnosed with early breast cancer facing the choice of mastectomy or breast conservation surgery with radiotherapy. However, research does not always reflect the complexities of decision making and is often atheoretical. A theoretical approach, as provided by the CSM and the TPB, could help to identify and tailor support by focusing on patients’ representations of their breast cancer and predicting surgery choices. Design  Literature search and narrative synthesis of data. Synthesis  Twenty‐six studies reported women’s surgery choices to be influenced by perceived clinical outcomes of surgery, appearance and body image, treatment concerns, involvement in decision making and preferences of clinicians. These factors can be mapped onto the key constructs of both the TPB and CSM and used to inform the design and development of decision support interventions to ensure accurate information is provided in areas most important to patients. Conclusions  The TPB and CSM have the potential to inform the design of decision support for breast cancer patients, with accurate and clear information that avoids leading patients to make decisions they may come to regret. Further research is needed examining how the components of the extended TPB and CSM account for patients’ surgery choices. PMID:20579123

Final Environmental Assessment for Conventional Strike Missile Demonstration

DTIC Science & Technology

2010-08-11

impacts of conducting a single demonstration flight test of the Conventional Strike Missile (CSM). The CSM Demonstration flight test vehicle would...Vehicle would glide at hypersonic velocities in the upper atmosphere, prior to a land or ocean impact at the US Army Kwajalein Atoll/Reagan Test Site...SIGNIFICANT IMPACT ENVIRONMENTAL ASSESSMENT FOR CONVENTIONAL STRIKE MISSILE DEMONSTRATION AGENCY: United States Air Force (USAF) BACKGROUND

The CSM and the NCO Support Channel.

DTIC Science & Technology

1988-03-30

the NCO support channel functions . And it would be wrong to blame the CSM for conflicts between the chain of command and the NCO support channel. It is...model for all noncommissioned officers and soldiers of the unit. However, Command Sergeant Majors are conditioned to function in a dual channel of ... the premier role model for all noncommissioned officers and soldiers of the unit.

The Asian-Australian Monsoon and El Niño-Southern Oscillation in the NCAR Climate System Model*.

NASA Astrophysics Data System (ADS)

Meehl, Gerald A.; Arblaster, Julie M.

1998-06-01

Features associated with the Asian-Australian monsoon system and El Niño-Southern Oscillation (ENSO) are described in the National Center for Atmospheric Research (NCAR) global coupled Climate System Model (CSM). Simulation characteristics are compared with a version of the atmospheric component of the CSM, the NCAR CCM3, run with time-evolving SSTs from 1950 to 1994, and with observations. The CSM is shown to represent most major features of the monsoon system in terms of mean climatology, interannual variability, and connections to the tropical Pacific. This includes a representation of the Southern Oscillation links between strong Asian-Australian monsoons and associated negative SST anomalies in the eastern equatorial Pacific. The equatorial SST gradient across the Pacific in the CSM is shown to be similar to the observed with somewhat cooler mean SSTs across the entire Pacific by about 1°-2°C. The seasonal cycle of SSTs in the eastern equatorial Pacific has the characteristic signature seen in the observations of relatively warmer SSTs propagating westward in the first half of the year followed by the reestablishment of the cold tongue with relatively colder SSTs propagating westward in the second half of the year. Like other global coupled models, the propagation is similar to the observed but with the establishment of the relatively warmer water in the first half of the year occurring about 1-2 months later than observed. The seasonal cycle of precipitation in the tropical eastern Pacific is also similar to other global coupled models in that there is a tendency for a stronger-than-observed double ITCZ year round, particularly in northern spring, but with a well-reproduced annual maximum of ITCZ strength north of the equator in the second half of the year. Time series of area-averaged SSTs for the NINO3 region in the eastern equatorial Pacific show that the CSM is producing about 60% of the amplitude of the observed variability in that region, consistent with most other global coupled models. Global correlations between NINO3 time series, global surface temperatures, and sea level pressure (SLP) show that the CSM qualitatively reproduces the major spatial patterns associated with the Southern Oscillation (lower SLP in the central and eastern tropical Pacific when NINO3 SSTs are relatively warmer and higher SLP over the far western Pacific and Indian Oceans, with colder water in the northwest and southwest Pacific). Indices of Asian-Australian monsoon strength are negatively correlated with NINO3 SSTs as in the observations. Spectra of time series of Indian monsoon, Australian monsoon, and NINO3 SST indices from the CSM show amplitude peaks in the Southern Oscillation and tropospheric biennial oscillation frequencies (3-6 yr and about 2.3 yr, respectively) as observed. Lag correlations between the NINO3 SST index and upper-ocean heat content along the equator show eastward propagation of heat content anomalies with a phase speed of about 0.3 m s1, compared to observed values of roughly 0.2 m s1. Composites of El Niño (La Niña) events in the CSM show similar seasonal evolution to composites of observed events with warming (cooling) of greater than several tenths of a degree beginning early in northern spring of year 0 and diminishing around northern spring of year +1, but with a secondary resurgence in the CSM events later in northern spring of year +1. The CSM also shows the largest amplitude ENSO SST and low-level wind anomalies in the western tropical Pacific, with enhanced interannual variability of SSTs extending northeastward and southeastward toward the subtropics, compared to largest interannual SST variability in the central and eastern tropical Pacific in the observations.

Arthroplasty for cervical spondylotic myelopathy: similar results to patients with only radiculopathy at 3 years' follow-up.

PubMed

Fay, Li-Yu; Huang, Wen-Cheng; Wu, Jau-Ching; Chang, Hsuan-Kan; Tsai, Tzu-Yun; Ko, Chin-Chu; Tu, Tsung-Hsi; Wu, Ching-Lan; Cheng, Henrich

2014-09-01

Cervical arthroplasty has been accepted as a viable option for surgical management of cervical spondylosis or degenerative disc disease (DDD). The best candidates for cervical arthroplasty are young patients who have radiculopathy caused by herniated disc with competent facet joints. However, it remains uncertain whether arthroplasty is equally effective for patients who have cervical myelopathy caused by DDD. The aim of this study was to compare the outcomes of arthroplasty for patients with cervical spondylotic myelopathy (CSM) and patients with radiculopathy without CSM. A total of 151 consecutive cases involving patients with CSM or radiculopathy caused by DDD and who underwent one- or two-level cervical arthroplasty were included in this study. Clinical outcome evaluations and radiographic studies were reviewed. Clinical outcome measurements included the Visual Analog Scale (VAS) of neck and arm pain, Japanese Orthopaedic Association (JOA) scores, and the Neck Disability Index (NDI) in every patient. For patients with CSM, Nurick scores were recorded for evaluation of cervical myelopathy. Radiographic studies included lateral dynamic radiographs and CT for detection of the formation of heterotopic ossification . Of the 151 consecutive patients with cervical DDD, 125 (82.8%; 72 patients in the myelopathy group and 53 in the radiculopathy group) had at least 24 months of clinical and radiographic follow-up. The mean duration of follow-up in these patients was 36.4 months (range 24-56 months). There was no difference in sex distribution between the 2 groups. However, the mean age of the patients in the myelopathy group was approximately 6 years greater than that of the radiculopathy group (53.1 vs 47.2 years, p < 0.001). The mean operation time, mean estimated blood loss, and the percentage of patients prescribed perioperative analgesic agents were similar in both groups (p = 0.754, 0.652, and 0.113, respectively). There were significant improvements in VAS neck and arm pain, JOA scores, and NDI in both groups. Nurick scores in the myelopathy group also improved significantly after surgery. In radiographic evaluations, 92.5% of patients in the radiculopathy group and 95.8% of those in the radiculopathy group retained spinal motion (no significant difference). Evaluation of CT scans showed heterotopic ossification in 34 patients (47.2%) in the myelopathy group and 25 patients (47.1%) in the radiculopathy group (p = 0.995). At a mean of over 3 years postoperatively, no secondary surgery was reported in either group. The severity of myelopathy improves after cervical arthroplasty in patients with CSM caused by DDD. At 3-year follow-up, the clinical and radiographic outcomes of cervical arthroplasty in DDD patients with CSM are similar to those patients who have only cervical radiculopathy. Therefore, cervical arthroplasty is a viable option for patients with CSM caused by DDD who require anterior surgery. However, comparison with the standard surgical treatment of anterior cervical discectomy and fusion is necessary to corroborate the outcomes of arthroplasty for CSM.

Effects of inositol, inositol-generating phytase B applied alone, and in combination with 6-phytase A to phosphorus-deficient diets on laying performance, eggshell quality, yolk cholesterol, and fatty acid deposition in laying hens.

PubMed

Zyla, K; Mika, M; Duliński, R; Swiatkiewicz, S; Koreleski, J; Pustkowiak, H; Piironen, J

2012-08-01

Phytase B, a product of Aspergillus niger phyB gene expressed in Trichoderma reesei, which increased myo-inositol concentrations in 20 mM sodium phytate solution 7.5-fold during 120-min incubation, a combination of phytase B with 6-phytase A, and pure myo-inositol were tested as feed supplements in Bovans Brown laying hens. In the 2-factorial experiment (2×5), birds from wk 50 to 62 were fed 2 basal diets, corn-soybean (CSM) or wheat-soybean (WSM), using 12 one-hen cages per treatment. For both basal diets, the dietary treatments included negative control (0.08% nonphytate P in CSM, 0.13% nonphytate P in WSM; NC); internal control groups, NC+0.04% nonphytate P from monocalcium phosphate, MCP (IC); NC+0.1% of myo-inositol (Inos), NC+phytase B at 1,300 units of phytase B-acid phosphatase activity (AcPU)/kg (PhyB), NC+phytase B at 1,300 AcPU/kg+6-phytase A at 300 FTU/kg (PhyA+B). Feed intake, laying performance, and eggshell quality were determined. The total lipid and cholesterol contents as well as fatty acid profile were assessed in egg yolks collected from hens fed CSM diets, as was fatty acid profile. The hens fed the WSM diet consumed significantly more feed, laid a higher mass of eggs daily with higher mean weights, and had a higher hen-day egg production than the birds receiving the CSM diets. Similarly, higher values for yolk weights, shell weights, shell thickness, shell density, and breaking strengths were determined in the eggs laid by the hens fed the WSM diets. In hens fed either the CSM diets with phytase B alone, or in combination with 6-phytase A, enhanced feed intakes, egg mass, and hen-day egg production were recorded. Phytases also enhanced the eggshell quality parameters in the hens fed both variants of the diets. Phytase B alone, or in combination with 6-phytase A, reduced the total lipid and cholesterol concentrations in egg yolks collected from the hens fed the CSM diets, whereas the combination of both phytases improved the n-6:n-3 polyunsaturated fatty acids ratio. In the CSM diets, the supplemental myo-inositol suppressed feed intakes, reduced egg production, had no effect on eggshell quality and reduced the deposition of eicosanoid fatty acids in yolks. When comparing the effects of feeding MCP, myo-inositol, and phytases on the nutritional quality of the eggs laid by the hens fed phosphorus-deficient CSM diets, it seems that the enhancements in nutritional quality cannot be attributed solely to higher phosphorus level or higher concentrations of myo-inositol.

Competing risk analysis of mortality in prostate cancer treated with radical prostatectomy.

PubMed

Ruiz-Cerdá, J L; Soto-Poveda, A; Luján-Marco, S; Loras-Monfort, A; Trassierra-Villa, M; Rogel-Bertó, R; Boronat-Tormo, F

To determine the risk of cancer-specific mortality (CSM) versus the competing risk of mortality by other causes (MOC) in patients with localised prostate cancer (LPC) treated with radical prostatectomy (RP). An observational cohort study of 982 patients with LPC treated with RP selected from our department's PC registry database. A competing risk analysis was performed, calculating the probability of CSM in the presence of the competing risk of MOC. Cumulative incidence curves were constructed, and point estimates were performed at 5, 10 and 15 years. The analysis was stratified by age (≤65 vs. >65 years) and risk group: low (Gleason score ≤6 and pT2abc); intermediate (Gleason score of 7 and pT2abc) and high (Gleason score of 8-10 or pT3ab). With a median follow-up of 60 months, the overall probability of dying from PC was 3.5%, and the probability of dying from other causes was 9%. A competing effect for MOC was observed. The risk of MOC was almost 3 times greater than that of CSM. This effect remained for all risk groups, although its magnitude decreased progressively according to the risk group level. At 10 years, CSM was only 0%, 1% and 2% for the low, intermediate and high-risk groups, respectively, while the likelihood of MOC was 4%, 4% and 10%, respectively. The mortality risk was shown after 10years of follow-up and was higher for other causes not attributable to PC and for patients older than 65years. The benefit of RP might be overestimated, given that the risk of MOC is greater than that of CSM, regardless of the age group and risk group, especially after 10years of follow-up. The only parameter that varied was the magnitude of the CSM/MOC ratio. This information could help in choosing the active treatment for patients with LPC and short life expectancies. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

Pakistan/USAID to start CSM project.

PubMed

1984-01-01

Pakistan, with the assistance of funds for the US Agency for International Development (USAID), is about to start its novel approach to contraceptive social marketing (CSM). This new effort suggests a marked policy shift on the part of the Pakistan government toward intensifying its family planning activities. The program will be government-operated and supported by AID over the next 5 years with $20 million, more than double the cost of similar CSM projects elswhere. Distribution of a condom on a pilot project basis is expected to begin by December 1984. Sales of a low-dose oral contraceptive (OC) could begin in test market areas by mid-1985, with national launching of both products tentatively scheduled for January 1986. The Pakistan/USAID agreement represents the 1st time since the formation of India's Nirodh project in the late 1960s that a CSM program is being established without the involvement of either an international social marketing contractor or a country's family planning association. The Pakistan CSM program will be managed by a policy board composed of representatives from the government's Ministries of Planning, Health and Education; a resident advisor from USAID; and a local company responsible for product marketing and distribution. The approach has received a skeptical response among international social marketing experts about the program's chances for success. Their doubts extend to 2 other aspects of the proposed design: an official of the Ministry of Planning's Population and Welfare Division expects the CSM program to generate sufficient revenues to cover all operating costs following the 5-year subsidy period, while also providing attractive profit margins for the marketing/distribution company; and the government prohibits mass media advertising of contraceptives. According to AID, the issue of mass media contraceptive advertising has not yet been resolved, and a national survey will be conducted to determine what communication needs are required for product promotion. In addition, AID's agreement requires a yearly review by the Pakistan government of its marketing strategies. The Pakistan government hopes that its new emphasis on family planning can slow the country's annual rate of population growth from 1983's 2.9% figure to 2.6% by 1988.

Using Case Studies in Calculus-based Physics

NASA Astrophysics Data System (ADS)

Katz, Debora M.

2006-12-01

Do your students believe that the physics only works in your classroom or laboratory? Or do they see that physics underlies their everyday experience? Case studies in physics help students connect physics principles to their everyday experience. For decades, case studies have been used to teach law, medicine and biology, but they are rarely used in physics. I am working on a calculus-based physics textbook for scientists and engineers. Case studies are woven into each chapter. Stop by and get a case study to test out in your classroom. I would love to get your feedback.

USAF Test Pilot School. Performance Phase Textbook. Volume 1

DTIC Science & Technology

1986-04-01

60" is twice as hot as 30* even though 60’ $ 30’ = 2. The reason is that our zero point is arbitrary. Zero degrees Farenheit does not mean the...by absolute mvaitude, ignoring t0* zero differ- Sence gives: Rank 2.5 2.5 2.5 2,5 6 6 6 8.5 8,5 Difference -1 1 1 -1 2 2 2 3 3 • ,•eAXe now .W+ 2.5...uti•n . . . . . . . . . . . . . . 3.24 3.11 goe Lift• • ..... • • 3.29 4-! Table of Contents (continued) Chapter Page 3.12 Zero Lift Line

Constraints on the Progenitor of SN 2010jl and Pre-existing Hot Dust in its Surrounding Medium

NASA Technical Reports Server (NTRS)

Dwek, Eli; Arendt, Richard G.; Fox, Ori D.; Kelly, Patrick L.; Smith, Nathan; Van Dyk, Schuyler D.; Filippenko, Alexei, V.; Andrews, Jennifer; Shivvers, Isaac

2017-01-01

A search for the progenitor of SN 2010jl, an unusually luminous core-collapse supernova of Type IIn, using pre-explosion Hubble/WFPC2 and Spitzer/IRAC images of the region, yielded upper limits on the UV and near infrared (IR) fluxes from any candidate star. These upper limits constrain the luminosity and effective temperature of the progenitor, the mass of any pre-existing dust in its surrounding circumstellar medium (CSM), and dust proximity to the star. A lower limit on the CSM dust mass is required to hide a luminous progenitor from detection by Hubble. Upper limits on the CSM dust mass and constraints on its proximity to the star are set by requiring that the absorbed and reradiated IR emission not exceed the IRAC upper limits. Using the combined extinction-IR emission constraints, we present viable M(sub d)-R(sub 1) combinations, where M(sub d) and R(sub 1) are the CSM dust mass and its inner radius. These depend on the CSM outer radius, dust composition and grain size, and the properties of the progenitor. The results constrain the pre-supernova evolution of the progenitor, and the nature and origin of the observed post-explosion IR emission from SN 2010jl. In particular, an eta Car-type progenitor will require at least 4 mag of visual extinction to avoid detection by Hubble. This can be achieved with dust masses greater than approximately equal to 10(exp -3) solar mass (less than the estimated 0.2-0.5 solar mass around eta Car), which must be located at distances of greater than approximately equal to 10(exp 16) cm from the star to avoid detection by Spitzer.

Three-Dimensional Kinematic Gait Analysis of Doberman Pinschers with and without Cervical Spondylomyelopathy

PubMed Central

Foss, K.; da Costa, R.C.; Moore, S.

2014-01-01

Background The optimal treatment of cervical spondylomyelopathy (CSM) is controversial, with the owner’s and clinician’s perception of gait improvement often being used as outcome measures. These methods are subjective and suffer from observer bias. Objectives To establish kinematic gait parameters utilizing digital motion capture in normal Doberman Pinschers and compare them with CSM-affected Dobermans. Animals Nineteen Doberman Pinschers; 10 clinically normal and 9 with CSM. Methods All dogs were enrolled prospectively and fitted with a Lycra® body suit, and motion capture was performed and used to reconstruct a 3-D stick diagram representation of each dog based on 32 reflective markers, from which several parameters were measured. These included stride duration, length, and height; maximal and minimal spinal angles; elbow and stifle flexion and extension; and maximum and minimum distances between the thoracic and pelvic limbs. A random-effects linear regression model was used to compare parameters between groups. Results Significant differences between groups included smaller minimum (mean = 116 mm; P = .024) and maximum (mean = 184 mm; P = .001) distance between the thoracic limbs in CSM-affected dogs. Additionally, thoracic limb stride duration was also smaller (P = .009) in CSM-affected dogs (mean = 0.7 seconds) when compared with normal dogs (mean = 0.8 seconds). In the pelvic limbs, the average stifle flexion (mean = 100°; P = .048) and extension (mean = 136°; P = .009), as well as number of strides (mean = 2.7 strides; P = .033) were different between groups. Conclusions and Clinical Importance Our findings suggest that computerized gait analysis reveals more consistent kinematic differences in the thoracic limbs, which can be used as future objective outcome measures. PMID:23194100

Towards a "Golden Standard" for computing globin stability: Stability and structure sensitivity of myoglobin mutants.

PubMed

Kepp, Kasper P

2015-10-01

Fast and accurate computation of protein stability is increasingly important for e.g. protein engineering and protein misfolding diseases, but no consensus methods exist for important proteins such as globins, and performance may depend on the type of structural input given. This paper reports benchmarking of six protein stability calculators (POPMUSIC 2.1, I-Mutant 2.0, I-Mutant 3.0, CUPSAT, SDM, and mCSM) against 134 experimental stability changes for mutations of sperm-whale myoglobin. Six different high-resolution structures were used to test structure sensitivity that may impair protein calculations. The trend accuracy of the methods decreased as I-Mutant 2.0 (R=0.64-0.65), SDM (R=0.57-0.60), POPMUSIC2.1 (R=0.54-0.57), I-Mutant 3.0 (R=0.53-0.55), mCSM (R=0.35-0.47), and CUPSAT (R=0.25-0.48). The mean signed errors increased as SDM

Effects of fermented cottonseed meal on the growth performance, gastrointestinal microflora population and small intestinal morphology in broiler chickens.

PubMed

Jazi, V; Boldaji, F; Dastar, B; Hashemi, S R; Ashayerizadeh, A

2017-08-01

1. This experiment was conducted to evaluate the effects of replacing dietary cottonseed meal (CSM) or fermented cottonseed meal (FCSM) for soya bean meal (SBM) on growth performance, carcass characteristics, gastrointestinal microbial populations, and intestinal morphology of broiler chickens. 2. CSM was fermented with Bacillus subtilis, Aspergillus niger and A. oryzae for 7 d. A total of 300 one-d-old male Ross 308 broiler chickens were used in a 42-d experiment in which the birds were randomly allotted to one of 5 dietary treatments (containing 0%, 10% and 20% CSM or FCSM) in a completely randomised design. Birds were reared on litter floor and had free access to feed and water during the experiment. 3. Results indicated that the fermentation process significantly reduced crude fibre and free gossypol, while it increased crude protein content and lactic acid bacteria (LAB) count in CSM. 4. The use of FCSM instead of CSM significantly improved growth performance of broilers. The abdominal fat yield in treatments containing FCSM was significantly lower than in the other treatments. The increase in the population of LAB in the crop and decrease in the population of coliforms in the ileum of birds fed on diets containing FCSM were more significant than in other birds. Villi in the duodenum and jejunum of the birds fed on diets containing FCSM were significantly higher than for the other experimental groups. 5. The positive effects of diets containing FCSM on growth performance and intestinal health of broiler chickens showed that this processed source of protein can serve as an appropriate alternative for SBM in diets for broiler chickens.

Refining the site conceptual model at a former uranium mill site in Riverton, Wyoming, USA

DOE PAGES

Dam, William; Campbell, Sam; Johnson, Ray; ...

2015-07-07

Milling activities at a former uranium mill site near Riverton, Wyoming, USA, contaminated the shallow groundwater beneath and downgradient of the site. Although the mill operated for <6 years (1958-1963), its impact remains an environmental liability. Groundwater modeling predicted that contaminant concentrations were declining steadily, which confirmed the conceptual site model (CSM). However, local flooding in 2010 mobilized contaminants that migrated downgradient from the Riverton site and resulted in a dramatic increase in groundwater contaminant concentrations. This observation indicated that the original CSM was inadequate to explain site conditions and needed to be refined. In response to the new observationsmore » after the flood, a collaborative investigation to better understand site conditions and processes commenced. This investigation included installing 103 boreholes to collect soil and groundwater samples, sampling and analysis of evaporite minerals along the bank of the Little Wind River, an analysis of evaportranspiration in the shallow aquifer, and sampling naturally organic-rich sediments near groundwater discharge areas. The enhanced characterization revealed that the existing CSM did not account for high uranium concentrations in groundwater remaining on the former mill site and groundwater plume stagnation near the Little Wind River. Observations from the flood and subsequent investigations indicate that additional characterization is still needed to continue refining the CSM and determine the viability of the natural flushing compliance strategy. Additional sampling, analysis, and testing of soil and groundwater are necessary to investigate secondary contaminant sources, mobilization of contaminants during floods, geochemical processes, contaminant plume stagnation, distribution of evaporite minerals and organic-rich sediments, and mechanisms and rates of contaminant transfer from soil to groundwater. Future data collection will be used to continually revise the CSM and evaluate the compliance strategy at the site.« less

Identification of Radar Facies and Linked Process-Based Palaeo-environmental Interpretations, Cooloola Sand Mass, Queensland, Australia

NASA Astrophysics Data System (ADS)

Gontz, A. M.; McCallum, A. B.; Moss, P. T.; Shulmeister, J.

2015-12-01

During 2015 and 2014, nearly 60 km of high-resolution ground penetrating radar data were acquired on the Cooloola Sand Mass (CSM) in southeastern coastal Queensland. The CSM is part of the world's largest downdrift sand system. It contains three of the world's largest sand islands, several National Parks, a UNESCO World Heritage Site and covers 500 km of the eastern Australian coastline in northern New South Wales and southern Queensland. The large (>200 m) composite dunes of the CSM exhibit multiple activation phases, coastally eroding bluffs and dune development is not obvious from surficial exposures. This provides an ideal environment for ground penetrating radar. The dune sequences have been provisionally dated to the mid Quaternary through present and represent the potential for a large palaeo-environmental proxy dataset. GPR imagery was collected using a MALA GeoSciences Ground Explorer (GX) system with 160 and 450 MHz antennae from the numerous physiographic and ecological provinces as well as mapped surficial soil units at the CSM. These data were used to determine the subsurface architecture, identify radar facies and develop environmental interpretations. In the clean, aeolian quartz-rich sands, radar wave penetration exceeded 30 m (radar velocity = 0.07 m/ns) with the 160 MHz antenna. From the interpreted environmental units including palaeosol, dune slip face, dune stoss face, sand blow, beach, estuarine and fluvial, we are developing maps to relate the units and focus a detailed sampling regime that includes OSL, sediment geochemistry and sedimentology, The interpreted units, stratigraphic correlation and spatial distribution of the facies is the first step in a broader project to unravel the Quaternary environmental and climate records that are archived within the sediments of the CSM.

Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body.

PubMed

Xiaopeng, Bai; Tanaka, Yoshimasa; Ihara, Eikichi; Hirano, Katsuya; Nakano, Kayoko; Hirano, Mayumi; Oda, Yoshinao; Nakamura, Kazuhiko

2017-02-15

Duodenal reflux of fluids containing trypsin relates to refractory gastroesophageal reflux disease (GERD). Esophageal peristalsis and clearance are important factors in GERD pathogenesis. However, the function of trypsin in esophageal body contractility is not fully understood. In this study, effects of trypsin on circular smooth muscle (CSM) and longitudinal smooth muscle (LSM) of the porcine esophageal body were examined. Trypsin elicited a concentration dependent biphasic response, a major contraction and a subsequent relaxation only in CSM. In CSM, contraction occurred at trypsin concentrations of 100nM and relaxation at 1μM. A proteinase-activated receptor (PAR)2 activating peptide, SLIGKV-NH 2 (1mM), induced a monophasic contraction. Those responses were unaffected by tetrodotoxin though abolished by the gap junction uncouplers carbenoxolone and octanol. They were also partially inhibited by a transient receptor potential vanilloid type 1 (TRPV1) antagonist and abolished by combination of neurokinin receptor 1 (NK 1 ) and NK 2 antagonists, but not by an NK 3 antagonist, suggesting a PAR2-TRPV1-substance P pathway in sensory neurons. Substance P (100nM), an agonist for various NK receptors (NK 1 , NK 2 and NK 3 ) with differing affinities, induced significant contraction in CSM, but not in LSM. The contraction was also blocked by the combination of NK 1 and NK 2 antagonists, but not by the NK 3 antagonist. Moreover, substance P-induced contractions were unaffected by the TRPV1 antagonist, but inhibited by a gap junction uncoupler. In conclusion, trypsin induced a biphasic response only in CSM and this was mediated by PAR2, TRPV1 and NK 1/2 . Gap junctions were indispensable in this tachykinin-induced response. Copyright © 2017 Elsevier B.V. All rights reserved.

TWO DISTINCT-ABSORPTION X-RAY COMPONENTS FROM TYPE IIn SUPERNOVAE: EVIDENCE FOR ASPHERICITY IN THE CIRCUMSTELLAR MEDIUM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katsuda, Satoru; Tsuboi, Yohko; Maeda, Keiichi

2016-12-01

We present multi-epoch X-ray spectral observations of three Type IIn supernovae (SNe), SN 2005kd, SN 2006jd, and SN 2010jl, acquired with Chandra , XMM-Newton , Suzaku , and Swift . Previous extensive X-ray studies of SN 2010jl have revealed that X-ray spectra are dominated by thermal emission, which likely arises from a hot plasma heated by a forward shock propagating into a massive circumstellar medium (CSM). Interestingly, an additional soft X-ray component was required to reproduce the spectra at a period of ∼1–2 years after the SN explosion. Although this component is likely associated with the SN, its origin remained an open question. Wemore » find a similar, additional soft X-ray component from the other two SNe IIn as well. Given this finding, we present a new interpretation for the origin of this component; it is thermal emission from a forward shock essentially identical to the hard X-ray component, but directly reaches us from a void of the dense CSM. Namely, the hard and soft components are responsible for the heavily and moderately absorbed components, respectively. The co-existence of the two components with distinct absorptions as well as the delayed emergence of the moderately absorbed X-ray component could be evidence for asphericity of the CSM. We show that the X-ray spectral evolution can be qualitatively explained by considering a torus-like geometry for the dense CSM. Based on our X-ray spectral analyses, we estimate the radius of the torus-like CSM to be on the order of ∼5 × 10{sup 16} cm.« less

Rumen Degradability and Post-ruminal Digestion of Dry Matter, Nitrogen and Amino Acids of Three Protein Supplements

PubMed Central

Gao, Wei; Chen, Aodong; Zhang, Bowen; Kong, Ping; Liu, Chenli; Zhao, Jie

2015-01-01

This study evaluated the in situ ruminal degradability, and subsequent small intestinal digestibility (SID) of dry matter, crude protein (CP), and amino acids (AA) of cottonseed meal (CSM), sunflower seed meal (SFSM) and distillers dried grains with solubles (DDGS) by using the modified three-step in vitro procedure. The ruminal degradability and subsequent SID of AA in rumen-undegradable protein (RUP-AA) varied among three protein supplements. The result show that the effective degradability of DM for SFSM, CSM, and DDGS was 60.8%, 56.4%, and 41.0% and their ruminal fermentable organic matter was 60.0%, 55.9%, and 39.9%, respectively. The ruminal degradable protein (RDP) content in CP for SFSM, CSM, and DDGS was 68.3%, 39.0%, and 32.9%, respectively, at the ruminal solid passage rate of 1.84%/h. The SFSM is a good source of RDP for rumen micro-organisms; however, the SID of RUP of SFSM was lower. The DDGS and CSM are good sources of RUP for lambs to digest in the small intestine to complement ruminal microbial AA of growing lambs. Individual RUP-AA from each protein source was selectively removed by the rumen micro-organisms, especially for Trp, Arg, His, and Lys (p<0.01). The SID of individual RUP-AA was different within specific RUP origin (p<0.01). Limiting amino acid was Leu for RUP of CSM and Lys for both RUP of SFSM and DDGS, respectively. Therefore, different protein supplements with specific limitations should be selected and combined carefully in growing lambs ration to optimize AA balance. PMID:25656208

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dam, William; Campbell, Sam; Johnson, Ray

Milling activities at a former uranium mill site near Riverton, Wyoming, USA, contaminated the shallow groundwater beneath and downgradient of the site. Although the mill operated for <6 years (1958-1963), its impact remains an environmental liability. Groundwater modeling predicted that contaminant concentrations were declining steadily, which confirmed the conceptual site model (CSM). However, local flooding in 2010 mobilized contaminants that migrated downgradient from the Riverton site and resulted in a dramatic increase in groundwater contaminant concentrations. This observation indicated that the original CSM was inadequate to explain site conditions and needed to be refined. In response to the new observationsmore » after the flood, a collaborative investigation to better understand site conditions and processes commenced. This investigation included installing 103 boreholes to collect soil and groundwater samples, sampling and analysis of evaporite minerals along the bank of the Little Wind River, an analysis of evaportranspiration in the shallow aquifer, and sampling naturally organic-rich sediments near groundwater discharge areas. The enhanced characterization revealed that the existing CSM did not account for high uranium concentrations in groundwater remaining on the former mill site and groundwater plume stagnation near the Little Wind River. Observations from the flood and subsequent investigations indicate that additional characterization is still needed to continue refining the CSM and determine the viability of the natural flushing compliance strategy. Additional sampling, analysis, and testing of soil and groundwater are necessary to investigate secondary contaminant sources, mobilization of contaminants during floods, geochemical processes, contaminant plume stagnation, distribution of evaporite minerals and organic-rich sediments, and mechanisms and rates of contaminant transfer from soil to groundwater. Future data collection will be used to continually revise the CSM and evaluate the compliance strategy at the site.« less

A Guided Tour of Mathematical Methods - 2nd Edition

NASA Astrophysics Data System (ADS)

Snieder, Roel

2004-09-01

Mathematical methods are essential tools for all physical scientists. This second edition provides a comprehensive tour of the mathematical knowledge and techniques that are needed by students in this area. In contrast to more traditional textbooks, all the material is presented in the form of problems. Within these problems the basic mathematical theory and its physical applications are well integrated. The mathematical insights that the student acquires are therefore driven by their physical insight. Topics that are covered include vector calculus, linear algebra, Fourier analysis, scale analysis, complex integration, Green's functions, normal modes, tensor calculus, and perturbation theory. The second edition contains new chapters on dimensional analysis, variational calculus, and the asymptotic evaluation of integrals. This book can be used by undergraduates, and lower-level graduate students in the physical sciences. It can serve as a stand-alone text, or as a source of problems and examples to complement other textbooks. All the material is presented in the form of problems Mathematical insights are gained by getting the reader to develop answers themselves Many applications of the mathematics are given

Algorithms and software for solving finite element equations on serial and parallel architectures

NASA Technical Reports Server (NTRS)

Chu, Eleanor; George, Alan

1988-01-01

The primary objective was to compare the performance of state-of-the-art techniques for solving sparse systems with those that are currently available in the Computational Structural Mechanics (MSC) testbed. One of the first tasks was to become familiar with the structure of the testbed, and to install some or all of the SPARSPAK package in the testbed. A brief overview of the CSM Testbed software and its usage is presented. An overview of the sparse matrix research for the Testbed currently employed in the CSM Testbed is given. An interface which was designed and implemented as a research tool for installing and appraising new matrix processors in the CSM Testbed is described. The results of numerical experiments performed in solving a set of testbed demonstration problems using the processor SPK and other experimental processors are contained.

Analysis of Plume Impingement Effects from Orion Crew Service Module Dual Reaction Control System Engine Firings

NASA Technical Reports Server (NTRS)

Prisbell, Andrew; Marichalar, J.; Lumpkin, F.; LeBeau, G.

2010-01-01

Plume impingement effects on the Orion Crew Service Module (CSM) were analyzed for various dual Reaction Control System (RCS) engine firings and various configurations of the solar arrays. The study was performed using a decoupled computational fluid dynamics (CFD) and Direct Simulation Monte Carlo (DSMC) approach. This approach included a single jet plume solution for the R1E RCS engine computed with the General Aerodynamic Simulation Program (GASP) CFD code. The CFD solution was used to create an inflow surface for the DSMC solution based on the Bird continuum breakdown parameter. The DSMC solution was then used to model the dual RCS plume impingement effects on the entire CSM geometry with deployed solar arrays. However, because the continuum breakdown parameter of 0.5 could not be achieved due to geometrical constraints and because high resolution in the plume shock interaction region is desired, a focused DSMC simulation modeling only the plumes and the shock interaction region was performed. This high resolution intermediate solution was then used as the inflow to the larger DSMC solution to obtain plume impingement heating, forces, and moments on the CSM and the solar arrays for a total of 21 cases that were analyzed. The results of these simulations were used to populate the Orion CSM Aerothermal Database.

Health behaviour models and patient preferences regarding nutrition and physical activity after breast or prostate cancer diagnosis.

PubMed

Green, H J; Steinnagel, G; Morris, C; Laakso, E L

2014-09-01

This study aimed to improve understanding of prostate and breast cancer survivors' physical activity and nutrition and the association of these behaviours with two models. The first model, the Commonsense Self-Regulation Model (CSM), addresses cognitive and emotional perceptions of illness whereas the Transtheoretical Model (TTM) focuses on stage of readiness to engage in a behaviour. Participants who had been diagnosed with either breast (n = 145) or prostate cancer (n = 92) completed measures of demographic and health information, illness representations, stage of change, self-efficacy and preferences regarding health behaviour interventions. Health behaviours in the past seven days were measured via the International Physical Activity Questionnaire and concordance with national dietary guidelines. As hypothesised, TTM variables (stage of change and self-efficacy) demonstrated independent associations with physical activity and nutrition in regression analyses. CSM variables were not independently associated with absolute levels of health behaviours but both TTM and CSM variables were independently associated with self-reported changes in physical activity and nutrition following prostate or breast cancer diagnosis. Many participants reported high interest in receiving lifestyle interventions, particularly soon after diagnosis. Results supported application of the TTM and CSM models for strengthening behaviour change intentions and actions in breast and prostate cancer survivors. © 2014 John Wiley & Sons Ltd.

Immunogenicity and protective efficacy of Semliki forest virus replicon-based DNA vaccines encoding goatpox virus structural proteins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng Min; Guangxi Center for Animal Disease Control and Prevention, Nanning 530001; College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062

Goatpox, caused by goatpox virus (GTPV), is an acute feverish and contagious disease in goats often associated with high morbidity and high mortality. To resolve potential safety risks and vaccination side effects of existing live attenuated goatpox vaccine (AV41), two Semliki forest virus (SFV) replicon-based bicistronic expression DNA vaccines (pCSm-AAL and pCSm-BAA) which encode GTPV structural proteins corresponding to the Vaccinia virus proteins A27, L1, A33, and B5, respectively, were constructed. Then, theirs ability to induce humoral and cellular response in mice and goats, and protect goats against virulent virus challenge were evaluated. The results showed that, vaccination with pCSm-AALmore » and pCSm-BAA in combination could elicit strong humoral and cellular responses in mice and goats, provide partial protection against viral challenge in goats, and reduce disease symptoms. Additionally, priming vaccination with the above-mentioned DNA vaccines could significantly reduce the goats' side reactions from boosting vaccinations with current live vaccine (AV41), which include skin lesions at the inoculation site and fevers. Data obtained in this study could not only facilitate improvement of the current goatpox vaccination strategy, but also provide valuable guidance to suitable candidates for evaluation and development of orthopoxvirus vaccines.« less

First-principles thermodynamics study of phase stability in inorganic halide perovskite solid solutions

NASA Astrophysics Data System (ADS)

Bechtel, Jonathon S.; Van der Ven, Anton

2018-04-01

Halide substitution gives rise to a tunable band gap as a function of composition in halide perovskite materials. However, photoinduced phase segregation, observed at room temperature in mixed halide A Pb (IxBr1-x) 3 systems, limits open circuit voltages and decreases photovoltaic device efficiencies. We investigate equilibrium phase stability of orthorhombic P n m a γ -phase CsM (XxY1-x) 3 perovskites where M is Pb or Sn, and X and Y are Br, Cl, or I. Finite-temperature phase diagrams are constructed using a cluster expansion effective Hamiltonian parameterized from first-principles density-functional-theory calculations. Solid solution phases for CsM (IxBr1-x) 3 and CsM (BrxCl1-x) 3 are predicted to be stable well below room temperature while CsM (IxCl1-x) 3 systems have miscibility gaps that extend above 400 K. The height of the miscibility gap correlates with the difference in volume between end members. Also layered ground states are found on the convex hull at x =2 /3 for CsSnBr2Cl ,CsPbI2Br , and CsPbBrCl2. The impact of these ground states on the finite temperature phase diagram is discussed in the context of the experimentally observed photoinduced phase segregation.

Dynamics of Atmospheric Boundary Layers: Large-Eddy Simulations and Reduced Analytical Models

NASA Astrophysics Data System (ADS)

Momen, Mostafa

Real-world atmospheric and oceanic boundary layers (ABL) involve many inherent complexities, the understanding and modeling of which manifestly exceeds our current capabilities. Previous studies largely focused on the "textbook ABL", which is (quasi) steady and barotropic. However, it is evident that the "real-world ABL", even over flat terrain, rarely meets such simplifying assumptions. The present thesis aims to illustrate and model four complicating features of ABLs that have been overlooked thus far despite their ubiquity: 1) unsteady pressure gradients in neutral ABLs (Chapters 2 and 3), 2) interacting effects of unsteady pressure gradients and static stability in diabatic ABLs (Chapter 4), 3) time-variable buoyancy fluxes (Chapter 5) , and 4) impacts of baroclinicity in neutral and diabatic ABLs (Chapter 6). State-of-the-art large-eddy simulations will be used as a tool to explain the underlying physics and to validate analytical models we develop for these features. Chapter 2 focuses on the turbulence equilibrium: when the forcing time scale is comparable to the turbulence time scale, the turbulence is shown to be out of equilibrium, and the velocity profiles depart from the log-law; However, for longer, and surprisingly for shorter forcing times, quasi-equilibrium is maintained. In Chapter 3, a reduced analytical model, based on the Navier-Stokes equations, will be introduced and shown to be analogous to a damped oscillator where inertial, Coriolis, and friction forces mirror the mass, spring, and damper, respectively. When a steady buoyancy (stable or unstable) is superposed on the unsteady pressure gradient, the same model structure can be maintained, but the damping term, corresponding to friction forces and vertical coupling, needs to account for stability. However, for the reverse case with variable buoyancy flux and stability, the model needs to be extended to allow time-variable damper coefficient. These extensions of the analytical model are presented respectively in Chapters 4 and 5. Chapter 6 investigates the interacting effects of baroclinicity (direction and strength) and stability on ABLs. Cold advection and positive shear increased the friction velocity, the low-level jet elevation and strength while warm advection and negative shear acted opposite. Finally, Chapter 7 provides a synthesis and a future outlook.

A microgenetic study of learning about the molecular theory of matter and chemical reactions

NASA Astrophysics Data System (ADS)

Chinn, Clark Allen

This paper reports the results of an experimental microgenetic study of children learning complex knowledge from text and experiments. The study had two goals. The first was to investigate fine-grained, moment-to-moment changes in knowledge as middle-school students learned about molecules and chemical reactions over thirteen sessions. The second was to investigate the effects of two instructional treatments, one using implicit textbook explanations and one using explicit explanations developed according to a theory of how scientific knowledge is structured. In the study, 61 sixth- and seventh-graders worked one on one with undergraduate instructors in eleven sessions of about 50 to 80 minutes. The instructors guided the students in conducting experiments and thinking out loud about texts. Topics studied included molecules, states of matter, chemical reactions, and heat transfer. A dense array of questions provided a detailed picture of children's moment-to-moment and day-to-day changes in knowledge. Three results chapters address students' preinstructional knowledge, the effects of the experimental treatment at posttest, and five detailed case studies of students' step-by-step knowledge change over eleven sessions. The chapter on preinstructional knowledge discussed three aspects of global knowledge change: conceptual change, coherence, and entrenchment. Notably, this chapter provides systematic evidence that children's knowledge was fragmented and that consistency with general unifying principles did not guarantee a highly coherent body of knowledge. The experimental manipulation revealed a strong advantage for explicit explanations over implicit textbook explanations. Multiple explicit explanations (e.g., highly explicit explanations of three or four chemical reactions) appeared to be necessary for students to master key concepts. Microgenetic analyses of five cases addressed eight empirical issues that should be addressed by any theory of knowledge acquisition: (a) the nature of the overall knowledge change, (b) the progression of intermediate states during knowledge change, (c) initiators of knowledge change, (d) interactions of prior background knowledge and prior domain knowledge during knowledge changes, (e) the fate of old and new knowledge, (f) the relationship between belief and knowledge, (g) changes in meta-awareness, and (h) factors that influenced the course of knowledge change.

Stellar Populations. A User Guide from Low to High Redshift

NASA Astrophysics Data System (ADS)

Greggio, Laura; Renzini, Alvio

2011-09-01

This textbook is meant to illustrate the specific role played by stellar population diagnostics in our attempt to understand galaxy formation and evolution. The book starts with a rather unconventional summary of the results of stellar evolution theory (Chapter 1), as they provide the basis for the construction of synthetic stellar populations. Current limitations of stellar models are highlighted, which arise from the necessity to parametrize all those physical processes that involve bulk mass motions, such as convection, mixing, mass loss, etc. Chapter 2 deals with the foundations of the theory of synthetic stellar populations, and illustrates their energetics and metabolic functions, providing basic tools that will be used in subsequent chapters. Chapters 3 and 4 deal with resolved stellar populations, first addressing some general problems encountered in photometric studies of stellar fields. Then some highlights are presented illustrating our current capacity of measuring stellar ages in Galactic globular clusters, in the Galactic bulge and in nearby galaxies. Chapter 5 is dedicated to the exemplification of synthetic spectra of simple as well as composite stellar populations, drawing attention to those spectral features that may depend on less secure results of stellar evolution models. Chapter 6 illustrates how synthetic stellar populations are used to derive basic galaxy properties, such as star formation rates, stellar masses, ages and metallicities, and does so for galaxies at low as well as at high redshifts. Chapter 7 is dedicated to supernovae, distinguishing them in core collapse and thermonuclear cases, describing the evolution of their rates for various star formation histories, and estimating the supernova productivity of stellar populations and their chemical yields. In Chapter 8 the stellar initial mass function (IMF) is discussed, first showing how even apparently small IMF variations may have large effects on the demo! graphy of stellar populations, and then using galaxies at low ! and high redshifts and clusters of galaxies to set tight constraints on possible IMF variations in space or time. In Chapter 9 a phenomenological model of galaxy evolution is presented which illustrates a concrete application of the stellar population tools described in the previous chapters. Finally, Chapter 10 is dedicated to the chemical evolution on the scale of galaxies, clusters of galaxies and the whole Universe.

Dorsal scapular nerve neuropathy: a narrative review of the literature

PubMed Central

Muir, Brad

2017-01-01

Objective The purpose of this paper is to elucidate this little known cause of upper back pain through a narrative review of the literature and to discuss the possible role of the dorsal scapular nerve (DSN) in the etiopathology of other similar diagnoses in this area including cervicogenic dorsalgia (CD), notalgia paresthetica (NP), SICK scapula and a posterolateral arm pain pattern. Background Dorsal scapular nerve (DSN) neuropathy has been a rarely thought of differential diagnosis for mid scapular, upper to mid back and costovertebral pain. These are common conditions presenting to chiropractic, physiotherapy, massage therapy and medical offices. Methods The methods used to gather articles for this paper included: searching electronic databases; and hand searching relevant references from journal articles and textbook chapters. Results One hundred-fourteen articles were retrieved. After removing duplicates, there were 57 articles of which 29 were retrieved. There were 26 articles and textbook chapters retrieved by hand searching equaling 55 articles retrieved of which 47 relevant articles were used in this report. Discussion The anatomy, pathway and function of the dorsal scapular nerve can be varied and exceptionally rarely may include a sensory component. The signs and symptoms, therefore, may include pain, atrophy, scapular winging, and dysesthesia. The mechanism of injury to the DSN is also quite varied ranging from postural to overuse in overhead work and sport. Other conditions in this area, including CD, NP, SICK scapula and a posterolateral arm pain pattern bear a striking resemblance to DSN neuropathy. Conclusion DSN neuropathy should be included in the list of common differential diagnoses of upper and mid-thoracic pain, stiffness, dysesthesia and dysfunction. The study also brings forward interesting connections between DSN neuropathy, CD, NP, SICK scapula and a posterolateral arm pain pattern. PMID:28928496

Teaching arrangements of carbohydrate metabolism in biochemistry curriculum in Peking University Health Science Center.

PubMed

Chen, Hao; Ni, Ju-Hua

2013-01-01

Biochemistry occupies a unique place in the medical school curricula, but the teaching of biochemistry presents certain challenges. One of these challenges is facilitating students' interest in and mastery of metabolism. The many pathways and modes of regulation can be overwhelming for students to learn and difficult for professors to teach in an engaging manner. The first chapter of the metabolism section in current Chinese biochemistry textbooks covers carbohydrate metabolism. Medical students usually complain about the difficulty of this subject. Here we discuss how to facilitate learning by rearranging the subjects in this introductory chapter of biochemical metabolism and to lay a solid foundation for future study. The strategy involves reorganizing the order in which subjects are taught from simple to complex and from short to long metabolic pathways. Most students taking the curriculum consider that the strategy engages their learning interests in biochemistry and enhances their learning outcomes. Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.

The science writing tool

NASA Astrophysics Data System (ADS)

Schuhart, Arthur L.

This is a two-part dissertation. The primary part is the text of a science-based composition rhetoric and reader called The Science Writing Tool. This textbook has seven chapters dealing with topics in Science Rhetoric. Each chapter includes a variety of examples of science writing, discussion questions, writing assignments, and instructional resources. The purpose of this text is to introduce lower-division college science majors to the role that rhetoric and communication plays in the conduct of Science, and how these skills contribute to a successful career in Science. The text is designed as a "tool kit," for use by an instructor constructing a science-based composition course or a writing-intensive Science course. The second part of this part of this dissertation reports on student reactions to draft portions of The Science Writing Tool text. In this report, students of English Composition II at Northern Virginia Community College-Annandale were surveyed about their attitudes toward course materials and topics included. The findings were used to revise and expand The Science Writing Tool.

The solar-terrestrial environment. An introduction to geospace - the science of the terrestrial upper atmosphere, ionosphere and magnetosphere.

NASA Astrophysics Data System (ADS)

Hargreaves, J. K.

This textbook is a successor to "The upper atmosphere and solar-terrestrial relations" first published in 1979. It describes physical conditions in the upper atmosphere and magnetosphere of the Earth. This geospace environment begins 70 kilometres above the surface of the Earth and extends in near space to many times the Earth's radius. It is the region of near-Earth environment where the Space Shuttle flies, the aurora is generated, and the outer atmosphere meets particles streaming out of the sun. The account is introductory. The intent is to present basic concepts, and for that reason the mathematical treatment is not complex. There are three introductory chapters that give basic physics and explain the principles of physical investigation. The principal material contained in the main part of the book covers the neutral and ionized upper atmosphere, the magetosphere, and structures, dynamics, disturbances and irregularities. The concluding chapter deals with technological applications.

Apollo Command/Service Modules photographed against black sky

NASA Image and Video Library

1971-02-04

AS14-66-9344 (February 1971) --- The Apollo Command and Service Modules (CSM) are photographed against a black sky background from the Lunar Module (LM) above the moon. While astronauts Alan B. Shepard Jr., commander, and Edgar D. Mitchell, lunar module pilot, descended in the LM "Antares" to explore the Fra Mauro region of the moon, astronaut Stuart A. Roosa , command module pilot, remained with the CSM "Kitty Hawk" in lunar orbit.

View of Skylab space station cluster in Earth orbit from CSM

NASA Image and Video Library

2008-08-18

SL4-143-4706 (8 Feb. 1974) --- An overhead view of the Skylab space station cluster in Earth orbit as photographed from the Skylab 4 Command and Service Modules (CSM) during the final fly-around by the CSM before returning home. The space station is contrasted against a cloud-covered Earth. Note the solar shield which was deployed by the second crew of Skylab and from which a micro meteoroid shield has been missing since the cluster was launched on May 14, 1973. The Orbital Workshop (OWS) solar panel on the left side was also lost on workshop launch day. Inside the Command Module (CM) when this picture was made were astronaut Gerald P. Carr, commander; scientist-astronaut Edward G. Gibson, science pilot; and astronaut William R. Pogue, pilot. The crew used a 70mm hand-held Hasselblad camera to take this photograph. Photo credit: NASA

Evaluation of breast tissue with confocal strip-mosaicking microscopy: a test approach emulating pathology-like examination

PubMed Central

Abeytunge, Sanjee; Larson, Bjorg; Peterson, Gary; Morrow, Monica; Rajadhyaksha, Milind

2017-01-01

Abstract. Confocal microscopy is an emerging technology for rapid imaging of freshly excised tissue without the need for frozen- or fixed-section processing. Initial studies have described imaging of breast tissue using fluorescence confocal microscopy with small regions of interest, typically 750×750  μm2. We present exploration with a microscope, termed confocal strip-mosaicking microscope (CSM microscope), which images an area of 2×2  cm2 of tissue with cellular-level resolution in 10 min of excision. Using the CSM microscope, we imaged 34 fresh, human, large breast tissue specimens from 18 patients, blindly analyzed by a board-certified pathologist and subsequently correlated with the corresponding standard fixed histopathology. Invasive tumors and benign tissue were clearly identified in CSM strip-mosaic images. Thirty specimens were concordant for image-to-histopathology correlation while four were discordant. PMID:28327961

Sparse matrix methods research using the CSM testbed software system

NASA Technical Reports Server (NTRS)

Chu, Eleanor; George, J. Alan

1989-01-01

Research is described on sparse matrix techniques for the Computational Structural Mechanics (CSM) Testbed. The primary objective was to compare the performance of state-of-the-art techniques for solving sparse systems with those that are currently available in the CSM Testbed. Thus, one of the first tasks was to become familiar with the structure of the testbed, and to install some or all of the SPARSPAK package in the testbed. A suite of subroutines to extract from the data base the relevant structural and numerical information about the matrix equations was written, and all the demonstration problems distributed with the testbed were successfully solved. These codes were documented, and performance studies comparing the SPARSPAK technology to the methods currently in the testbed were completed. In addition, some preliminary studies were done comparing some recently developed out-of-core techniques with the performance of the testbed processor INV.

Surrogate motherhood, rights and duties: a reply to Campbell.

PubMed

McLachlan, H V; Swales, J K

2001-01-01

In a recent article in Health Care Analysis (Vol. 8, No. 1), Campbell misrepresents our specific arguments about commercial surrogate motherhood (C.S.M.) and our general philosophical and political views by saying or suggesting that we are 'Millsian' liberals and consequentialists. He gives too the false impression that we do not oppose, in principle, slavery and child purchase. Here our position on C.S.M. is re-expressed and elaborated upon in order to eliminate possible confusion. Our general ethical and philosophical framework is also outlined and shown to be other than Campbell says that it is. In particular, a moral philosophy that is based on neither consequentialism nor Kantianism is presented. C.S.M., it is argued, is not child purchase. It is like it in some respects and unlike it in others. It is unlike it in the respects which, relative to the present discussion, matter.

Calculation of Expectation Values of Operators in the Complex Scaling Method

DOE PAGES

Papadimitriou, G.

2016-06-14

In the complex scaling method (CSM) provides with a way to obtain resonance parameters of particle unstable states by rotating the coordinates and momenta of the original Hamiltonian. It is convenient to use an L 2 integrable basis to resolve the complex rotated or complex scaled Hamiltonian H θ , with θ being the angle of rotation in the complex energy plane. Within the CSM, resonance and scattering solutions have fall-off asymptotics. Furthermore, one of the consequences is that, expectation values of operators in a resonance or scattering complex scaled solution are calculated by complex rotating the operators. In thismore » work we are exploring applications of the CSM on calculations of expectation values of quantum mechanical operators by using the regularized backrotation technique and calculating hence the expectation value using the unrotated operator. Moreover, the test cases involve a schematic two-body Gaussian model and also applications using realistic interactions.« less

Circumstellar Interaction in Supernovae in Dense Environments—An Observational Perspective

NASA Astrophysics Data System (ADS)

Chandra, Poonam

2018-02-01

In a supernova explosion, the ejecta interacting with the surrounding circumstellar medium (CSM) give rise to variety of radiation. Since CSM is created from the mass loss from the progenitor, it carries footprints of the late time evolution of the star. This is one of the unique ways to get a handle on the nature of the progenitor system. Here, I will focus mainly on the supernovae (SNe) exploding in dense environments, a.k.a. Type IIn SNe. Radio and X-ray emission from this class of SNe have revealed important modifications in their radiation properties, due to the presence of high density CSM. Forward shock dominance in the X-ray emission, internal free-free absorption of the radio emission, episodic or non-steady mass loss rate, and asymmetry in the explosion seem to be common properties of this class of SNe.

Coanda-Assisted Spray Manipulation Collar for a Commercial Plasma Spray Gun

NASA Astrophysics Data System (ADS)

Mabey, K.; Smith, B. L.; Whichard, G.; McKechnie, T.

2011-06-01

A Coanda-assisted Spray Manipulation (CSM) collar was retrofitted to a Praxair SG-100 plasma spray gun. The CSM device makes it possible to change the direction of (vector) the plasma jet and powder without moving the gun. The two-piece retrofit device replaces the standard faceplate. Two separate collars were tested: one designed for small vector angles and one for larger vector angles. It was demonstrated that the small-angle device could modify the trajectory of zirconia powder up to several degrees. Doing so could realign the plasma with the powder resulting in increased powder temperature and velocity. The large-angle device was capable of vectoring the plasma jet up to 45°. However, the powder did not vector as much. Under large-angle vectoring, the powder velocity and temperature decreased steadily with vector angle. Both devices were tested using a supersonic configuration to demonstrate that CSM is capable of vectoring supersonic plasmas.

Impact of Cervical Sagittal Alignment on Axial Neck Pain and Health-related Quality of Life After Cervical Laminoplasty in Patients With Cervical Spondylotic Myelopathy or Ossification of the Posterior Longitudinal Ligament: A Prospective Comparative Study.

PubMed

Fujiwara, Hiroyasu; Oda, Takenori; Makino, Takahiro; Moriguchi, Yu; Yonenobu, Kazuo; Kaito, Takashi

2018-05-01

This is prospective observational study. To prospectively investigate the correlation among axial neck pain; a newly developed patient-based quality of life outcome measure, the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ); and cervical sagittal alignment after open-door laminoplasty for cervical myelopathy. Many studies have focused on postoperative axial neck pain after laminoplasty. However, the correlation among cervical sagittal alignment, neck pain, and JOACMEQ has not been investigated. In total, 57 consecutive patients treated by open-door laminoplasty for cervical myelopathy were included (mean age, 63.7 y; 15 women and 42 men) and divided into 2 groups according to diagnosis [cervical spondylotic myelopathy (CSM) group: 35 patients, and ossification of the posterior longitudinal ligament (OPLL) group: 22 patients]. JOA score, a subdomain of cervical spine function (CSF) in the JOACMEQ, and the visual analog scale for axial neck pain were assessed preoperatively and 12 months postoperatively. Radiographic cervical sagittal parameters were measured by C2 sagittal vertical axis (C2 SVA), C2-C7 lordosis, C7 sagittal slope (C7 slope), and range of motion. C2 SVA values in both groups shifted slightly anteriorly between preoperative and 12-month postoperative measurements (CSM: +19.7±10.9 mm; OPLL: +22.1±13.4 mm vs. CSM: +23.2±16.1 mm; OPLL: +28.7±15.4 mm, respectively). Postoperative axial neck pain in the OPLL group showed strong negative correlations with C2 SVA and C7 slope. Strong negative correlations were found between axial neck pain and CSF in both the preoperative CSM and OPLL groups (CSM: r=-0.45, P=0.01; OPLL: r=-0.61, P<0.01) and between axial neck pain and CSF in the postoperative OPLL group (r=-0.51, P=0.05). This study demonstrated a significant negative correlation between neck pain and CSF in both the CSM and OPLL groups preoperatively and in the OPLL group postoperatively. Radiographic cervical sagittal alignment did not significantly correlate with preoperative or postoperative axial neck pain.

CSM: Profamilia's approach in Colombia.

PubMed

Samuel, S

1982-03-01

Colombia's PROFAMILIA has successfully operated a contraceptive social marketing (CSM) program since 1973. Beginning with 1 salesperson distributing primarily to Cajas de Subsideio, the CSM program is now distributed through 70-80% of the 6000 registered pharmacies in the country, as well as pharmacy counters of several supermakets in urban areas. During 1981, PROFAMILIA's 5 salespersons accountd for commerical sales of oral contraceptives (OCs) to 225,000 couples and sales of barrier methods to another 75,000. Program sales of contraceptives and other products generated approximately US $1.7 million in revenue for the same year. PROFAMILIA's marketing approach is unique in its product and promotinal characteristics. Supplies are obtained directly from local and foreign manufacturers and are resold without any repackaging. While it is generally believed that CSM programs expand the market for contraceptives, data analysis and analysis of PROFAMILIA's distribution system suggests that the PROFAMILIA CSM program has simply absorbed some of the previously existing commerical market. Total commerical market sales of oral contraceptives (OCs) have grown at an annual rate of 3-4% since 1975. During the same period, direct sales of Schering, Wyeth, and other competitors have declined. PROFAMILIA's community-based program operates mainly among urban and semi-rural lower income populations. It sells products through established retail outlets rather than through institutional or non-retail outlets. PROFAMILIA's community-based program in all respects but its use of a staff of 112 salaried "instructoras" is as much a marketing program as PROFAMILIA's sales through pharmacies. Taken together, the 2 program expanded the commerical makert by about 1/2 since 1975. The contraceptive social marketing or pharmacy sales program appears to excel at generation of revenue and delivery of products to higher income clients. The community-based program excels at delivery of information and sales to lower income clients. PROFAMILIA CSM and community-based program sales are in a period of relative stagnation. Sales projections show only modest increases between 1981-85, despite the fact that a significant number of potential consumers remain unserved. Ultimately, PROFAMILIA may be faced with the need to reduce their number markedly as sales revenue is eroded by inflation while costs rise. A shift in duties back to motivation rather than distribution, combined with increased media promotion seems the clearest short-term response to the problem of unserved consumers.

Cost/CYP: a bottom line that helps keep CSM projects cost-efficient.

PubMed

1985-01-01

In contraceptive social marketing (CSM), the objective is social good, but project managers also need to run a tight ship, trimming costs, allocating scarce funds, and monitoring their program's progress. 1 way CSM managers remain cost-conscious is through the concept of couple-years-of-protection (CYP). Devised 2 decades ago as an administrative tool to compare the effects of different contraceptive methods, CYP's uses have multiplied to include assessing program output and cost effectiveness. Some of the factors affecting cost/CYP are a project's age, sales volume, management efficiency, and product prices and line. These factors are interconnected. The cost/CYP figures given here do not include outlays for commodities. While the Agency for International Development's commodity costs alter slightly with each new purchase contrast, the agency reports that a condom costs about 4 cents (US), an oral contraceptive (OC) cycle about 12 cents, and a spermicidal tablet about 7 cents. CSM projects have relatively high start-up costs. Within a project's first 2 years, expenses must cover such marketing activities as research, packaging, warehousing, and heavy promotion. As a project ages, sales should grow, producing revenues that gradually amortize these initial costs. The Nepal CSM project provides an example of how cost/CYP can improve as a program ages. In 1978, the year sales began, the project's cost/CYP was about $84. For some time the project struggled to get its products to its target market and gradually overcome several major hurdles. The acquisition of jeeps eased distribution and, by adding another condom brand, sales were increased still more, bringing the cost/CYP down to $8.30 in 1981. With further sales increases and resulting revenues, the cost/CYP dropped to just over $7 in 1983. When the sales volume becomes large enough, CSM projects can achieve economies of scale, which greatly improves cost-efficiency. Fixed costs shrink as a proportion of total expenditures. Good project management goes hand-in-hand with increasing sales. Cost/CYP is a powerful tool, but some project strategies alter its meaning. Some projects have lowered net costs by selling products at high prices. This dilutes the social marketing credo of getting low-cost projects to those in need. When this occurs, cost/CYP undergoes an identity crisis, for it no longer measures a purely social objective.

SN 2017dio: A Type-Ic Supernova Exploding in a Hydrogen-rich Circumstellar Medium

NASA Astrophysics Data System (ADS)

Kuncarayakti, Hanindyo; Maeda, Keiichi; Ashall, Christopher J.; Prentice, Simon J.; Mattila, Seppo; Kankare, Erkki; Fransson, Claes; Lundqvist, Peter; Pastorello, Andrea; Leloudas, Giorgos; Anderson, Joseph P.; Benetti, Stefano; Bersten, Melina C.; Cappellaro, Enrico; Cartier, Régis; Denneau, Larry; Della Valle, Massimo; Elias-Rosa, Nancy; Folatelli, Gastón; Fraser, Morgan; Galbany, Lluís; Gall, Christa; Gal-Yam, Avishay; Gutiérrez, Claudia P.; Hamanowicz, Aleksandra; Heinze, Ari; Inserra, Cosimo; Kangas, Tuomas; Mazzali, Paolo; Melandri, Andrea; Pignata, Giuliano; Rest, Armin; Reynolds, Thomas; Roy, Rupak; Smartt, Stephen J.; Smith, Ken W.; Sollerman, Jesper; Somero, Auni; Stalder, Brian; Stritzinger, Maximilian; Taddia, Francesco; Tomasella, Lina; Tonry, John; Weiland, Henry; Young, David R.

2018-02-01

SN 2017dio shows both spectral characteristics of a type-Ic supernova (SN) and signs of a hydrogen-rich circumstellar medium (CSM). Prominent, narrow emission lines of H and He are superposed on the continuum. Subsequent evolution revealed that the SN ejecta are interacting with the CSM. The initial SN Ic identification was confirmed by removing the CSM interaction component from the spectrum and comparing with known SNe Ic and, reversely, adding a CSM interaction component to the spectra of known SNe Ic and comparing them to SN 2017dio. Excellent agreement was obtained with both procedures, reinforcing the SN Ic classification. The light curve constrains the pre-interaction SN Ic peak absolute magnitude to be around {M}g=-17.6 mag. No evidence of significant extinction is found, ruling out a brighter luminosity required by an SN Ia classification. These pieces of evidence support the view that SN 2017dio is an SN Ic, and therefore the first firm case of an SN Ic with signatures of hydrogen-rich CSM in the early spectrum. The CSM is unlikely to have been shaped by steady-state stellar winds. The mass loss of the progenitor star must have been intense, \\dot{M}∼ 0.02{({ε }{{H}α }/0.01)}-1 ({v}{wind}/500 km s‑1) ({v}{shock}/10,000 km s‑1)‑3 M ⊙ yr‑1, peaking at a few decades before the SN. Such a high mass-loss rate might have been experienced by the progenitor through eruptions or binary stripping. Based on observations made with the NOT, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. This work is based (in part) on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile as part of PESSTO, (the Public ESO Spectroscopic Survey for Transient Objects Survey) ESO program 188.D-3003, 191.D-0935, 197.D-1075. Based on observations made with the Liverpool Telescope operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias with financial support from the UK Science and Technology Facilities Council.

Book Review:

NASA Astrophysics Data System (ADS)

Poisson, E.

2005-10-01

The ever growing relevance of general relativity to astrophysics and cosmology continues to motivate the publication of new textbooks which put the theory in a fresh perspective informed by recent developments. In the last few years we have witnessed the appearance of two new books which reflect this trend, and which stand proud among the classic relativity texts. While the 1970s were the decade of Weinberg [1] and Misner et al [2], and the 80s the decade of Schutz [3] and Wald [4], this is clearly the decade of Hartle [5] and Carroll. Hartle has introduced a novel pedagogical approach to teaching general relativity, which he convincingly argues [6] should be done in the standard undergraduate physics curriculum. His 'physics-first approach' emphasizes physical phenomena and minimizes mathematical formalism. Hartle achieves a lot by introducing only the spacetime metric and the geodesic equation, which are the main tools needed to explore curved spacetime and extract physical consequences. To be sure, to explain how the metric is obtained in the first place does require a background of differential geometry and the formulation of the Einstein field equations. But in Hartle's book this material is wisely presented at a later stage, after an ample sampling of the physics of curved spacetime has motivated the need for the advanced mathematics. Carroll follows instead the traditional route, what Hartle calls the 'math-first approach', in which one introduces first the required mathematical formalism and only then derives the physical consequences. He is, of course, in good company, as this is the method followed in all existing textbooks (with Hartle's being the sole exception). Carroll's approach may not be original, but it is tried and true, and the result of Carroll's efforts is an excellent introduction to general relativity. The book covers the standard topics that would be found in virtually all textbooks (differential geometry, the field equations, linearized theory, black holes, and cosmology), but in addition it contains topics (such as quantum field theory in curved spacetime) which can rarely be found in introductory texts. All these topics are presented with authority and in great pedagogical style. I enjoy the book's informal, even conversational, tone, which helps Carroll establish a good rapport with the reader. All in all, this is a very usable text that offers a modern, viable alternative to existing books. My favourite part of the book is the first three chapters on differential geometry. The presentation of the mathematical formalism is crystal clear and very enjoyable, and it comes with a large number of helpful (and attractive) diagrams. Carroll's presentation of differential geometry is sophisticated but completely accessible, and it is quite broad. It includes all the topics that might be considered elementary (such as vectors and tensors, parallel transport, geodesics and curvature), but also a number of topics that might be considered advanced (such as differential forms, nonmetric connections, torsion, Lie differentiation and Killing vectors). Another particularly successful chapter is the fourth, which presents the Einstein field equations. These are first motivated in the usual way (as the simplest tensorial generalization of Poisson's equation), but are then derived from a variational principle. (This is done in the absence of the action's boundary term, whose inclusion would complicate matters and require machinery that Carroll does not introduce.) What I like most about this chapter is that alternative theories of gravitation (such as scalar-tensor theories and higher-dimensional versions of general relativity) get a fairly detailed treatment. Alternatives to general relativity are hardly ever discussed in textbooks, and this is a welcome initiative. The book's next two chapters are devoted to black holes. Carroll's treatment of the Schwarzschild spacetime is very detailed and complete, but his discussion of the Reissner-Nordström and Kerr spacetimes is far more sketchy. I would have liked to see an equally detailed presentation of these spacetimes. Carroll also provides a good descriptive account of the general properties of black-hole spacetimes. The book's seventh chapter contains a very enjoyable discussion of the linearized approximation to general relativity. The traditional presentation of this topic makes immediate use of the Lorenz gauge condition, which tends to create the (wrong) impression that all components of the gravitational field are radiative. With his careful treatment of gauge transformations, and his exploration of different gauge conditions, Carroll achieves the best textbook presentation of linearized theory to date. The theory is applied to calculate the deflection of light in a weak static field, and to the propagation of gravitational waves in flat spacetime. Less successfully, however, it is also applied to the generation of gravitational waves. Carroll presents the usual derivation of the quadrupole formula but fails to mention that the linearized theory is not an adequate foundation in the context of self-gravitating systems. It is a pity that the application of the quadrupole formula to binary stars does not come with such an important warning. Carroll next moves on to cosmology, a field of research that evolves so rapidly that any new textbook runs the risk of becoming rapidly outdated. This coverage of cosmology is well informed by the recent spectacular developments (including the supernovae data which reveal an accelerated expansion and the mapping of the anisotropies of the cosmic microwave background radiation (CMBR) which reveals a spatially flat universe). Carroll's presentation also includes a pedagogical account of the inflation paradigm, which has become an integral part of the standard cosmological model. This chapter, however, more than any other, left me wanting for more. I am disappointed that it contains no discussion of cosmological perturbations; this is a surprising omission, since the presentation of the linearized theory in chapter 7 is so clearly inspired by the cosmological problem. I am equally disappointed not to find a detailed discussion of the CMBR anisotropies; this omission also is surprising, since the peak structure of their multipole moments makes such a compelling case for inflationary ideas. Given that Carroll is a working cosmologist, it is indeed a surprise to me that this chapter on cosmology happens to be so brief. The ninth and final chapter of Carroll's book is devoted to a topic that has never been covered in an introductory text: quantum field theory in curved spacetime. To include this was a truly inspired thought, and Carroll is to be congratulated for this initiative. Quantum-field processes play an essential role in the physics of structure formation in the early universe, and they give rise to the famous Hawking effect which causes a black hole to behave as a thermal body. A complete education in general relativity cannot exclude this important subject, and we now have a textbook which presents it in a clear, accessible way. In summary, I am positively impressed by this book, in spite of the fact that I find it to be flawed in certain places. I firmly believe that the book stands proud among the best relativity texts. Would I use it in a general relativity course? The answer is: surely, given the right group of students. In the past I have had the pleasure of teaching both an introductory course for undergraduates and an advanced course for graduate students. In my opinion, none of these student groups are a good match for Carroll's book. For the undergraduate course I would choose Hartle over Carroll, as I much favour the physics-first approach. For the graduate course I rely on an existing working knowledge of general relativity and I cover advanced topics that are not found in Carroll's text. The right target group, I imagine, would be graduate students enrolled in an introductory course on general relativity. These students would require more sophistication than can be found in Hartle's book, and they would likely be a great match for Carroll's text. References [1] Weinberg S 1972 Gravitation and cosmology: Principles and applications of the general theory of relativity (New York: Wiley) [2] Misner C W, Thorne K S and Wheeler J A 1973 Gravitation (San Francisco: Freeman) [3] Schutz B F 1985 A First Course in General Relativity (Cambridge: Cambridge University Press) [4] Wald R M 1984 General Relativity (Chicago, IL: Chicago University Press) [5] Hartle J B 2003 Gravity: An Introduction to Einstein's General Relativity (San Francisco: Addison Wesley) [6] Hartle J B 2005 General relativity in the undergraduate physics curriculum Preprint gr-qc/0506075

Spacecraft Systems Engineering, 3rd Edition

NASA Astrophysics Data System (ADS)

Fortescue, Peter; Stark, John; Swinerd, Graham

2003-03-01

Following on from the hugely successful previous editions, the third edition of Spacecraft Systems Engineering incorporates the most recent technological advances in spacecraft and satellite engineering. With emphasis on recent developments in space activities, this new edition has been completely revised. Every chapter has been updated and rewritten by an expert engineer in the field, with emphasis on the bus rather than the payload. Encompassing the fundamentals of spacecraft engineering, the book begins with front-end system-level issues, such as environment, mission analysis and system engineering, and progresses to a detailed examination of subsystem elements which represent the core of spacecraft design - mechanical, electrical, propulsion, thermal, control etc. This quantitative treatment is supplemented by an appreciation of the interactions between the elements, which deeply influence the process of spacecraft systems design. In particular the revised text includes * A new chapter on small satellites engineering and applications which has been contributed by two internationally-recognised experts, with insights into small satellite systems engineering. * Additions to the mission analysis chapter, treating issues of aero-manouevring, constellation design and small body missions. In summary, this is an outstanding textbook for aerospace engineering and design students, and offers essential reading for spacecraft engineers, designers and research scientists. The comprehensive approach provides an invaluable resource to spacecraft manufacturers and agencies across the world.

Artist's concept of Apollo 14 Command/Service Modules circling Moon

NASA Image and Video Library

1971-01-11

S71-16574 (11 Jan. 1971) --- An artist's concept depicting the Apollo 14 Command and Service Modules (CSM) circling the moon as the Lunar Module (LM) heads toward a lunar landing. While astronaut Stuart A. Roosa, command module pilot, remains with the CSM in lunar orbit, astronauts Alan B. Shepard Jr., commander; and Edgar D. Mitchell, lunar module pilot, will descend in the LM to explore an area in the rugged Fra Mauro highlands.

Time Sensitive Termination: Prompt Global Strike in the War on Terror

DTIC Science & Technology

2009-10-25

field both near and long term solutions to the problem of rapidly destroying fleeting targets halfway around the world when forces are not forward...endeavors to field the near term capability not later than 2015, with an initial fielding objective potentially as early as 2012. 5 The program will...patrolling ballistic missile submarines, the CSM took center stage in the effort to field a near -term solution to the problem. The CSM weapon system

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2013-04-26

developing scramjet — supersonic combustion ramjet—technologies that may contribute to the long-range strike mission in the future. In this type of vehicle ... vehicle that could deploy on a modified Peacekeeper land- based ballistic missile—a system known as the Conventional Strike Missile (CSM). In FY2008...into the Air Force CSM and two possible hypersonic glide vehicles . Congress appropriated $174.8 million for CPGS capability development in FY2012. DOD

Analysis of the project synthesis goal cluster orientation and inquiry emphasis of elementary science textbooks

NASA Astrophysics Data System (ADS)

Staver, John R.; Bay, Mary

The purpose of this descriptive study was to examine selected units of commonly used elementary science texts, using the Project Synthesis goal clusters as a framework for part of the examination. An inquiry classification scheme was used for the remaining segment. Four questions were answered: (1) To what extent do elementary science textbooks focus on each Project Synthesis goal cluster? (2) In which part of the text is such information found? (3) To what extent are the activities and experiments merely verifications of information already introduced in the text? (4) If inquiry is present in an activity, then what is the level of such inquiry?Eleven science textbook series, which comprise approximately 90 percent of the national market, were selected for analysis. Two units, one primary (K-3) and one intermediate (4-6), were selected for analysis by first identifying units common to most series, then randomly selecting one primary and one intermediate unit for analysis.Each randomly selected unit was carefully read, using the sentence as the unit of analysis. Each declarative and interrogative sentence in the body of the text was classified as: (1) academic; (2) personal; (3) career; or (4) societal in its focus. Each illustration, except those used in evaluation items, was similarly classified. Each activity/experiment and each miscellaneous sentence in end-of-chapter segments labelled review, summary, evaluation, etc., were similarly classified. Finally, each activity/experiment, as a whole, was categorized according to a four-category inquiry scheme (confirmation, structured inquiry, guided inquiry, open inquiry).In general, results of the analysis are: (1) most text prose focuses on academic science; (2) most remaining text prose focuses on the personal goal cluster; (3) the career and societal goal clusters receive only minor attention; (4) text illustrations exhibit a pattern similar to text prose; (5) text activities/experiments are academic in orientation, almost to the exclusion of other goal clusters; (6) end-of-chapter sentences are largely academic; (7) inquiry is absent or present only in limited forms in text activities/experiments; and (8) texts allocate only a minor portion of space to activities/experiments. Detailed findings are given as numeral, percentage, and decimal values. Discussion focuses on the implications of the results and a comparison of NSTA recommendations with the results of this analysis.

Effects of Reduced Terrestrial LiDAR Point Density on High-Resolution Grain Crop Surface Models in Precision Agriculture

PubMed Central

Hämmerle, Martin; Höfle, Bernhard

2014-01-01

3D geodata play an increasingly important role in precision agriculture, e.g., for modeling in-field variations of grain crop features such as height or biomass. A common data capturing method is LiDAR, which often requires expensive equipment and produces large datasets. This study contributes to the improvement of 3D geodata capturing efficiency by assessing the effect of reduced scanning resolution on crop surface models (CSMs). The analysis is based on high-end LiDAR point clouds of grain crop fields of different varieties (rye and wheat) and nitrogen fertilization stages (100%, 50%, 10%). Lower scanning resolutions are simulated by keeping every n-th laser beam with increasing step widths n. For each iteration step, high-resolution CSMs (0.01 m2 cells) are derived and assessed regarding their coverage relative to a seamless CSM derived from the original point cloud, standard deviation of elevation and mean elevation. Reducing the resolution to, e.g., 25% still leads to a coverage of >90% and a mean CSM elevation of >96% of measured crop height. CSM types (maximum elevation or 90th-percentile elevation) react differently to reduced scanning resolutions in different crops (variety, density). The results can help to assess the trade-off between CSM quality and minimum requirements regarding equipment and capturing set-up. PMID:25521383

Comparison of Functional and Radiological Outcomes Between Two Posterior Approaches in the Treatment of Multilevel Cervical Spondylotic Myelopathy.

PubMed

Ren, Da-Jiang; Li, Fang; Zhang, Zhi-Cheng; Kai, Guan; Shan, Jian-Lin; Zhao, Guang-Min; Sun, Tian-Sheng

2015-08-05

Posterior cervical decompression is an accepted treatment for multilevel cervical spondylotic myelopathy (CSM). Each posterior technique has its own advantages and disadvantages. In the present study, we compared the functional and radiological outcomes of expansive hemilaminectomy and laminoplasty with mini titanium plate in the treatment of multilevel CSM. Forty-four patients with multilevel CSM treated with posterior cervical surgery in Department of Orthopedic Surgery, Beijing Army General Hospital from March 2011 to June 2012 were enrolled in this retrospective study. Patients were divided into two groups by surgical procedure: Laminoplasty (Group L) and hemilaminectomy (Group H). Perioperative parameters including age, sex, duration of symptoms, operative duration, and intraoperative blood loss were recorded and compared. Spinal canal area, calculated using AutoCAD ® software(Autodesk Inc., San Rafael, CA, USA), and neurological improvement, evaluated with Japanese Orthopedic Association score, were also compared. Neurological improvement did not differ significantly between groups. Group H had a significantly shorter operative duration and significantly less blood loss. Mean expansion ratio was significantly greater in Group L (77.83 ± 6.41%) than in Group H (62.72 ± 3.86%) (P < 0.01). Both surgical approaches are safe and effective in treating multilevel CSM. Laminoplasty provides a greater degree of enlargement of the spinal canal, whereas expansive hemilaminectomy has the advantages of shorter operative duration and less intraoperative blood loss.

The Top 50 Most-Cited articles on Cervical Spondylotic Myelopathy (CSM).

PubMed

Malik, Azeem Tariq; Jain, Nikhil; Yu, Elizabeth; Khan, Safdar N

2018-06-02

Cervical Spondylotic Myelopathy (CSM) occurs due to chronic degenerative changes in the cervical spine causing compression of the spinal cord. CSM has been studied for decades and there are innumerable articles published on the topic. We sought to identify the top 50 most cited articles on CSM. The top 50 cited articles were retrieved from the SCOPUS database using the search criteria "cervical spondylosis with myelopathy" OR "cervical spondylotic myelopathy." Levels of evidence were also calculated. Descriptive and statistical analysis was also carried out. The total number of citations of the top 50 papers was 7072. The paper with the highest number of citations was 287. All articles were published between 1966-2010, with most articles being published between 1990 and 1999(N=22). The most prolific country in terms of the total number of publications was United States with 25 publications followed by Japan. Majority of the articles were Level IV. There is a deficiency of high-level articles in the top 50 most cited list. The study provides an important overview of historical development of treatment methods as well as publication trends related to this pathology. Regardless, this is a comprehensive list of the top 50 most cited articles for future trainees and surgeons to use as resource to build up knowledge base. Copyright © 2018. Published by Elsevier Inc.

TGF-β1 related inflammation in the posterior longitudinal ligament of cervical spondylotic myelopathy patients.

PubMed

Wang, Jia-Zeng; Fang, Xiu-Tong; Lv, E; Yu, Fang; Wang, Zhen-Wei; Song, Hong-Xing

2015-01-01

This study aimed to elucidate the pathogenesis of posterior longitudinal ligament (PLL) hypertrophy. Cervical PLL specimens were collected from CSM patients during surgery (n = 30) and during routine autopsy (n = 14), and processed for histological examination (HE staining and Masson's Trichrome staining) and IHC (CD3, CD68, CD31, TGF-β1 and collagen II). In addition, the mRNA expression of collagen I was detected in cervical PLL specimens from 16 CSM patients (n = 16) and from routine autopsy (n = 16) by RT-PCR. Obvious fibrosis, cartilage metaplasia and calcification were found in the cervical PLL of CSM patients. In the degenerated PLL, CD68(+) macrophages were frequently identified, CD3(+) T lymphocytes were occasionally found, and many newly generated small vessels were also present. In the degenerated PLL, of the number of TGF-β1 positive cells increased markedly when compared with control group. IHC indicated TGF-β1 was secreted by macrophages. RT-PCR showed a significantly lower mRNA expression of collagen I in the PLL of CSM patients as compared to control group. Macrophages are the major type of inflammatory cells involved in the cervical PLL degeneration, and TGF-β1 is related to the cervical PLL degeneration. TGF-β1 is mainly secreted by macrophages. Anti-inflammation may serve as an alternative non-surgical treatment and prophylactic strategy for PLL degeneration.

Interacting Supernovae: Types IIn and Ibn

NASA Astrophysics Data System (ADS)

Smith, Nathan

Supernovae that show evidence of strong shock interaction between their ejecta and pre-existing slower circumstellar material (CSM) constitute an interesting, diverse, and still poorly understood category of explosive transients. The chief reason they are extremely interesting is because they tell us that in a subset of stellar deaths, the progenitor star becomes wildly unstable in the years, decades, or centuries before explosion. This is something that has not been included in standard stellar evolution models but may significantly change the end product and yield of that evolution and complicates our attempts to map SNe to their progenitors. Another reason they are interesting is because CSM interaction is an efficient engine for making bright transients, allowing superluminous transients to arise from normal SN explosion energy, and transients of normal supernova luminosity to arise from sub-energetic explosions or low radioactivity yield. CSM interaction shrouds the fast ejecta in bright shock emission, obscuring our view of the underlying explosion, and the radiation hydrodynamics is challenging to model. The CSM interaction may also be highly nonspherical, perhaps linked to binary interaction in the progenitor system. In some cases, these complications make it difficult to tell the difference between a core-collapse and thermonuclear explosion or to discern between a nonterminal eruption, failed supernova, or weak supernova. Efforts to uncover the physical parameters of individual events and connections to progenitor stars make this a rapidly evolving topic that challenges paradigms of stellar evolution.

Feasibility of partial replacement of fishmeal with proteins from different sources in diets of Korean rockfish ( Sebastes schlegeli)

NASA Astrophysics Data System (ADS)

Yan, Quangen; Zhu, Xiaoming; Yang, Yunxia; Han, Dong; Xie, Shouqi

2014-12-01

An 8-week feeding experiment was conducted in an indoor recirculation seawater system to investigate the effects of partial replacement of dietary fishmeal with proteins from five sources on the growth performance and feed utilization of Sebastes schlegeli. Six isonitrogenous and isoenergetic diets were formulated using fishmeal (FM, the control) as sole protein source, or proteins from five sources including poultry by-product meal (PBM), meat and bone meal (MBM), soybean meal (SBM), cottonseed meal (CSM) and canola meal (CNM). Fifteen percent of the crude protein provided by fish meal was replaced, respectively. The results showed that the differences in specific growth rate (SGR) and survival rate (SR) among fish fed PBM, MBM, SBM, CSM and whole FM diets were not significant. However, SGR and SR of fish fed CNM diet was significantly lower than that of other treatments. Feeding rate, feed conversion, nutrient retention showed similar patterns to that of growth. Fish fed CSM and CNM showed significantly lower apparent digestibility coefficient (ADC) of dry matter and gross energy than those fed others while fish fed CNM showed lower ADC of crude protein than those fed others ( P<0.05). These results suggested that it was feasible to substitute 15% dietary protein provided by fishmeal with PBM, MBM, SBM and CSM, respectively, but not with CNM as the replacement with CNM reduced fish growth and feed utilization.

The Effect of Online Chapter Quizzes on Exam Performance in an Undergraduate Social Psychology Course

PubMed Central

Johnson, Bethany C.; Kiviniemi, Marc T.

2009-01-01

Assigned textbook readings are a common requirement in undergraduate courses, but students often do not complete reading assignments or do not do so until immediately before an exam. This may have detrimental effects on learning and course performance. Regularly scheduled quizzes on reading material may increase completion of reading assignments and therefore course performance. This study examined the effectiveness of compulsory, mastery-based, weekly reading quizzes as a means of improving exam and course performance. Completion of reading quizzes was related to both better exam and course performance. The discussion includes recommendations for the use of quizzes in undergraduate courses. PMID:20046908

Book Review: Dolores Knipp’s Understanding Space Weather and the Physics Behind It

NASA Astrophysics Data System (ADS)

Moldwin, Mark

2012-08-01

Delores Knipp's textbook Understanding Space Weather and the Physics Behind It provides a comprehensive resource for space physicists teaching in a variety of academic departments to introduce space weather to advanced undergraduates. The book benefits from Knipp's extensive experience teaching introductory and advanced undergraduate physics courses at the U.S. Air Force Academy. The fundamental physics concepts are clearly explained and are connected directly to the space physics concepts being discussed. To expand upon the relevant basic physics, current research areas and new observations are highlighted, with many of the chapters including contributions from a number of leading space physicists.

Statistical methods for nuclear material management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowen W.M.; Bennett, C.A.

1988-12-01

This book is intended as a reference manual of statistical methodology for nuclear material management practitioners. It describes statistical methods currently or potentially important in nuclear material management, explains the choice of methods for specific applications, and provides examples of practical applications to nuclear material management problems. Together with the accompanying training manual, which contains fully worked out problems keyed to each chapter, this book can also be used as a textbook for courses in statistical methods for nuclear material management. It should provide increased understanding and guidance to help improve the application of statistical methods to nuclear material managementmore » problems.« less

A novel experimental model of erectile dysfunction in rats with heart failure using volume overload

PubMed Central

Silva, Fábio Henrique; Veiga, Frederico José Reis; Mora, Aline Gonçalves; Heck, Rodrigo Sader; De Oliveira, Caroline Candida; Gambero, Alessandra; Franco-Penteado, Carla Fernanda; Antunes, Edson; Gardner, Jason D.; Priviero, Fernanda Bruschi Marinho

2017-01-01

Background Patients with heart failure (HF) display erectile dysfunction (ED). However, the pathophysiology of ED during HF remains poorly investigated. Objective This study aimed to characterize the aortocaval fistula (ACF) rat model associated with HF as a novel experimental model of ED. We have undertaken molecular and functional studies to evaluate the alterations of the nitric oxide (NO) pathway, autonomic nervous system and oxidative stress in the penis. Methods Male rats were submitted to ACF for HF induction. Intracavernosal pressure in anesthetized rats was evaluated. Concentration-response curves to contractile (phenylephrine) and relaxant agents (sodium nitroprusside; SNP), as well as to electrical field stimulation (EFS), were obtained in the cavernosal smooth muscle (CSM) strips from sham and HF rats. Protein expression of endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) and phosphodiestarese-5 in CSM were evaluated, as well as NOX2 (gp91phox) and superoxide dismutase (SOD) mRNA expression. SOD activity and thiobarbituric acid reactive substances (TBARs) were also performed in plasma. Results HF rats display erectile dysfunction represented by decreased ICP responses compared to sham rats. The neurogenic contractile responses elicited by EFS were greater in CSM from the HF group. Likewise, phenylephrine-induced contractions were greater in CSM from HF rats. Nitrergic response induced by EFS were decreased in the cavernosal tissue, along with lower eNOS, nNOS and phosphodiestarese-5 protein expressions. An increase of NOX2 and SOD mRNA expression in CSM and plasma TBARs of HF group were detected. Plasma SOD activity was decreased in HF rats. Conclusion ED in HF rats is associated with decreased NO bioavailability in erectile tissue due to eNOS/nNOS dowregulation and NOX2 upregulation, as well as hypercontractility of the penis. This rat model of ACF could be a useful tool to evaluate the molecular alterations of ED associated with HF. PMID:29095897

A novel experimental model of erectile dysfunction in rats with heart failure using volume overload.

PubMed

Silva, Fábio Henrique; Veiga, Frederico José Reis; Mora, Aline Gonçalves; Heck, Rodrigo Sader; De Oliveira, Caroline Candida; Gambero, Alessandra; Franco-Penteado, Carla Fernanda; Antunes, Edson; Gardner, Jason D; Priviero, Fernanda Bruschi Marinho; Claudino, Mário Angelo

2017-01-01

Patients with heart failure (HF) display erectile dysfunction (ED). However, the pathophysiology of ED during HF remains poorly investigated. This study aimed to characterize the aortocaval fistula (ACF) rat model associated with HF as a novel experimental model of ED. We have undertaken molecular and functional studies to evaluate the alterations of the nitric oxide (NO) pathway, autonomic nervous system and oxidative stress in the penis. Male rats were submitted to ACF for HF induction. Intracavernosal pressure in anesthetized rats was evaluated. Concentration-response curves to contractile (phenylephrine) and relaxant agents (sodium nitroprusside; SNP), as well as to electrical field stimulation (EFS), were obtained in the cavernosal smooth muscle (CSM) strips from sham and HF rats. Protein expression of endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) and phosphodiestarese-5 in CSM were evaluated, as well as NOX2 (gp91phox) and superoxide dismutase (SOD) mRNA expression. SOD activity and thiobarbituric acid reactive substances (TBARs) were also performed in plasma. HF rats display erectile dysfunction represented by decreased ICP responses compared to sham rats. The neurogenic contractile responses elicited by EFS were greater in CSM from the HF group. Likewise, phenylephrine-induced contractions were greater in CSM from HF rats. Nitrergic response induced by EFS were decreased in the cavernosal tissue, along with lower eNOS, nNOS and phosphodiestarese-5 protein expressions. An increase of NOX2 and SOD mRNA expression in CSM and plasma TBARs of HF group were detected. Plasma SOD activity was decreased in HF rats. ED in HF rats is associated with decreased NO bioavailability in erectile tissue due to eNOS/nNOS dowregulation and NOX2 upregulation, as well as hypercontractility of the penis. This rat model of ACF could be a useful tool to evaluate the molecular alterations of ED associated with HF.

Deletion of a Chitin Synthase Gene in a Citric Acid Producing Strain of Aspergillus niger

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinker, Torri E.; Baker, Scott E.

Citric acid production by the filamentous fungus Aspergillus niger is carried out in a process that causes the organism to drastically alter its morphology. This altered morphology includes hyphal swelling and highly limited polar growth resulting in clumps of swollen cells that eventually aggregate into pellets of approximately 100 microns in diameter. In this pelleted form, A. niger has increased citric acid production as compared to growth in filamentous form. Chitin is a crucial component of the cell wall of filamentous fungi. Alterations in the deposition or production of chitin may have profound effects on the morphology of the organism.more » In order to study the role of chitin synthesis in pellet formation we have deleted a chitin synthase gene (csmA) in Aspergillus niger strain ATCC 11414 using a PCR based deletion construct. This class of chitin synthases is only found in filamentous fungi and is not present in yeasts. The csmA genes contain a myosin motor domain at the N-terminus and a chitin synthesis domain at the C-terminus. They are believed to contribute to the specialized polar growth observed in filamentous fungi that is lacking in yeasts. The csmA deletion strain (csmAΔ) was subjected to minimal media with and without osmotic stabilizers as well as tested in citric acid production media. Without osmotic stabilizers, the mutant germlings were abnormally swollen, primarily in the subapical regions, and contained large vacuoles. However, this swelling is ultimately not inhibitory to growth as the germlings are able to recover and undergo polar growth. Colony formation was largely unaffected in the absence of osmotic stabilizers. In citric acid production media csmAΔ was observed to have a 2.5 fold increase in citric acid production. The controlled expression of this class of chitin synthases may be useful for improving production of organic acids in filamentous fungi.« less

Cystic renal cell carcinoma carries an excellent prognosis regardless of tumor size.

PubMed

Winters, Brian R; Gore, John L; Holt, Sarah K; Harper, Jonathan D; Lin, Daniel W; Wright, Jonathan L

2015-12-01

Cystic renal cell carcinoma (cystic RCC) is thought to carry an improved prognosis relative to clear cell RCC (CCRCC); however, this is based on small case series. We used a population-based tumor registry to compare clinicopathologic features and cancer-specific mortality (CSM) of cystic RCC with those of CCRCC. The Surveillance, Epidemiology, and End Results database was queried for all patients diagnosed and treated for cystic RCC and CCRCC between 2001 and 2010. Clinical and pathologic factors were compared using t tests and chi-square tests as appropriate. Kaplan-Meier survival analysis compared CSM differences between cystic RCC and CCRCC. A total of 678 patients with cystic RCC and 46,677 with CCRCC were identified. The mean follow-up duration was 52 and 40 months, respectively. When compared with CCRCC patients, those with cystic RCC were younger (mean age 58 vs. 61 y, P < 0.001), more commonly black (22% vs. 9%, P < 0.001), and female (45% vs. 41%, P = 0.02). Cystic RCCs were more commonly T1a tumors (66% vs. 55%, P < 0.001), well differentiated (33% vs. 16%, P < 0.001), and smaller (mean size = 3.8 vs. 4.5 cm, P < 0.001). Cystic RCC was associated with a reduction in CSM when compared with CCRCC (P = 0.002). In a subset analysis, this reduction in CSM was seen only for those with T1b/T2 tumors (P = 0.01) but not for those with T1a RCCs lesions (P = 0.31). We report the largest series of cystic RCC and corroborate the findings of improved CSM when compared with CCRCC for larger tumors; however, no difference was noted in smaller tumors, suggesting that tumor biology becomes more relevant to prognosis with increasing size. These data may suggest a role for active surveillance in appropriately selected patients with small, cystic renal masses. Copyright © 2015 Elsevier Inc. All rights reserved.

Cystic renal cell carcinoma carries an excellent prognosis regardless of tumor size

PubMed Central

Winters, Brian R.; Gore, John L.; Holt, Sarah K.; Harper, Jonathan D.; Lin, Daniel W.; Wright, Jonathan L.

2016-01-01

Introduction Cystic renal cell carcinoma (cystic RCC) is thought to carry an improved prognosis relative to clear cell RCC (CCRCC); however, this is based on small case series. We used a population-based tumor registry to compare clinicopathologic features and cancer-specific mortality (CSM) of cystic RCC with those of CCRCC. Materials and methods The Surveillance, Epidemiology, and End Results database was queried for all patients diagnosed and treated for cystic RCC and CCRCC between 2001 and 2010. Clinical and pathologic factors were compared using t tests and chi-square tests as appropriate. Kaplan-Meier survival analysis compared CSM differences between cystic RCC and CCRCC. Results A total of 678 patients with cystic RCC and 46,677 with CCRCC were identified. The mean follow-up duration was 52 and 40 months, respectively. When compared with CCRCC patients, those with cystic RCC were younger (mean age 58 vs. 61 y, P < 0.001), more commonly black (22% vs. 9%, P < 0.001), and female (45% vs. 41%, P = 0.02). Cystic RCCs were more commonly T1a tumors (66% vs. 55%, P < 0.001), well differentiated (33% vs. 16%, P < 0.001), and smaller (mean size 3.8 vs. 4.5 cm, P < 0.001). Cystic RCC was associated with a reduction in CSM when compared with CCRCC (P = 0.002). In a subset analysis, this reduction in CSM was seen only for those with T1b/T2 tumors (P = 0.01) but not for those with T1a RCCs lesions (P = 0.31). Conclusions We report the largest series of cystic RCC and corroborate the findings of improved CSM when compared with CCRCC for larger tumors; however, no difference was noted in smaller tumors, suggesting that tumor biology becomes more relevant to prognosis with increasing size. These data may suggest a role for active surveillance in appropriately selected patients with small, cystic renal masses. PMID:26319351

Uncertainty and the Conceptual Site Model

NASA Astrophysics Data System (ADS)

Price, V.; Nicholson, T. J.

2007-12-01

Our focus is on uncertainties in the underlying conceptual framework upon which all subsequent steps in numerical and/or analytical modeling efforts depend. Experienced environmental modelers recognize the value of selecting an optimal conceptual model from several competing site models, but usually do not formally explore possible alternative models, in part due to incomplete or missing site data, as well as relevant regional data for establishing boundary conditions. The value in and approach for developing alternative conceptual site models (CSM) is demonstrated by analysis of case histories. These studies are based on reported flow or transport modeling in which alternative site models are formulated using data that were not available to, or not used by, the original modelers. An important concept inherent to model abstraction of these alternative conceptual models is that it is "Far better an approximate answer to the right question, which is often vague, than the exact answer to the wrong question, which can always be made precise." (Tukey, 1962) The case histories discussed here illustrate the value of formulating alternative models and evaluating them using site-specific data: (1) Charleston Naval Site where seismic characterization data allowed significant revision of the CSM and subsequent contaminant transport modeling; (2) Hanford 300-Area where surface- and ground-water interactions affecting the unsaturated zone suggested an alternative component to the site model; (3) Savannah River C-Area where a characterization report for a waste site within the modeled area was not available to the modelers, but provided significant new information requiring changes to the underlying geologic and hydrogeologic CSM's used; (4) Amargosa Desert Research Site (ADRS) where re-interpretation of resistivity sounding data and water-level data suggested an alternative geologic model. Simple 2-D spreadsheet modeling of the ADRS with the revised CSM provided an improved match to vapor-phase tritium migration. Site-specific monitoring coupled to these alternative CSM's greatly assists in conducting uncertainty assessments. (Work supported by USNRC contract NRC-04-03-061.)

The percutaneous toxicokinetics of Sulphur mustard in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant.

PubMed

Hall, Charlotte A; Lydon, Helen L; Dalton, Christopher H; Chipman, J Kevin; Graham, John S; Chilcott, Robert P

2017-09-01

This study used a damaged skin, porcine model to evaluate the in vivo efficacy of WoundStat™ for decontamination of superficial (non-haemorrhaging), sulphur mustard-contaminated wounds. The dorsal skin of 12 female pigs was subjected to controlled physical damage and exposed to 10 μL 14 C-radiolabelled sulphur mustard ( 14 C-SM). Animals were randomly assigned to either a control or a treatment group. In the latter, WoundStat™ was applied 30 s post exposure and left in situ for 1 h. Skin lesion progression and decontaminant efficacy were quantified over 6 h using a range of biophysical measurements. Skin, blood and organ samples were taken post mortem for histopathological assessment, 14 C-SM distribution and toxicokinetic analyses. Application of SM to damaged skin without decontamination was rapidly followed by advanced signs of toxicity, including ulceration and decreased blood flow at the exposure site in all animals. WoundStat™ prevented ulceration and improved blood flow at the exposure site in all decontaminated animals (n = 6). Furthermore, significantly smaller quantities of 14 C-SM were detected in the blood (45% reduction), and recovered from skin (70% reduction) and skin surface swabs (99% reduction) at 6 h post-challenge. Overall, the distribution of 14 C-SM in the internal organs was similar for both groups, with the greatest concentration in the kidneys, followed by the liver and small intestine. WoundStat™ significantly reduced the amount of 14 C-SM recovered from the liver, a key organ for SM metabolism and detoxification. This study demonstrates that WoundStat™ is a suitable product for reducing the ingress and toxicity of a chemical warfare agent. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Full-Text Publication of Abstract-Presented Work in Physical Therapy: Do Therapists Publish What They Preach?

PubMed Central

Smith, Heather D.; Bogenschutz, Elizabeth D.; Bayliss, Amy J.; Altenburger, Peter A.

2011-01-01

Background and Objective Professional meetings, such as the American Physical Therapy Association's (APTA's) Combined Sections Meeting (CSM), provide forums for sharing information relevant to physical therapy. An indicator of whether therapists fully disseminate their work is the number of full-text peer-reviewed publications that result. The purposes of this study were: (1) to determine the full-text publication rate of work presented in abstract form at CSM and (2) to investigate factors influencing this rate. Methods A systematic search was undertaken to locate full-text publications of work presented in abstract form within the Orthopaedic and Sports Physical Therapy sections at CSM between 2000 and 2004. Eligible publications were published within 5 years following abstract presentation. The influences of APTA section, year of abstract presentation, institution of origin, study design, sample size, study significance, reporting of a funding source, and presentation type on full-text publication rate were assessed. Characteristics of full-text publications were explored. Results Work presented in 1 out of 4 abstracts (25.4%) progressed to full-text publication. Odds of full-text publication increased if the abstract originated from a doctorate-granting or “other” institution, reported findings of an experimental study, reported a statistically significant finding, included a larger sample size, disclosed a funding source, or was presented as a platform presentation. More than one third (37.8%) of full-text publications were published in the Journal of Orthopaedic and Sports Physical Therapy or Physical Therapy, and 4 out of 10 full-text publications (39.2%) contained at least one major change from information presented in abstract form. Conclusions The full-text publication rate for information presented in abstract form within the Orthopaedic and Sports Physical Therapy sections at CSM is low relative to comparative disciplines. Caution should be exercised when translating information presented at CSM into practice. PMID:21169423

BOOK REVIEW: Introduction to 3+1 Numerical Relativity

NASA Astrophysics Data System (ADS)

Gundlach, Carsten

2008-11-01

This is the first major textbook on the methods of numerical relativity. The selection of material is based on what is known to work reliably in astrophysical applications and would therefore be considered by many as the 'mainstream' of the field. This means spacelike slices, the BSSNOK or harmonic formulation of the Einstein equations, finite differencing for the spacetime variables, and high-resolution shock capturing methods for perfect fluid matter. (Arguably, pseudo-spectral methods also belong in this category, at least for elliptic equations, but are not covered in this book.) The account is self-contained, and comprehensive within its chosen scope. It could serve as a primer for the growing number of review papers on aspects of numerical relativity published in Living Reviews in Relativity (LRR). I will now discuss the contents by chapter. Chapter 1, an introduction to general relativity, is clearly written, but may be a little too concise to be used as a first text on this subject at postgraduate level, compared to the textbook by Schutz or the first half of Wald's book. Chapter 2 contains a good introduction to the 3+1 split of the field equations in the form mainly given by York. York's pedagogical presentation (in a 1979 conference volume) is still up to date, but Alcubierre makes a clearer distinction between the geometric split and its form in adapted coordinates, as well as filling in some derivations. Chapter 3 on initial data is close to Cook's 2001 LRR, but is beautifully unified by an emphasis on how different choices of conformal weights suit different purposes. Chapter 4 on gauge conditions covers a topic on which no review paper exists, and which is spread thinly over many papers. The presentation is both detailed and unified, making this an excellent resource also for experts. The chapter reflects the author's research interests while remaining canonical. Chapter 5 covers hyperbolic reductions of the field equations. Alcubierre's excellent presentation is less technical than Reula's 1998 LRR or the 1995 book by Gustafsson, Kreiss and Oliger, but covers the key ideas in application to the Einstein equations. The reviewer (admittedly riding a hobby-horse) would argue that the hyperbolicity of the ADM and BSSNOK equations should have been investigated without introducing a specific first-order reduction. Chapter 6 covers gauge problems in numerical black hole spacetimes, black hole excision, and apparent horizons. Like chapter 4 it is both exhaustive and pedagogical. Perhaps more space than necessary is given here to work the author was involved in, while the section on slice stretching could have been more detailed, given that there is no good overview in the literature. Chapter 7 on relativistic hydrodynamics is, quite simply, excellent. Among many other useful things it contains some elementary material on equations of state that is not written up at this level elsewhere, a good mini-introduction to weak solutions of conservation laws, and a brief review of imperfect fluids in GR (Israel--Stewart theory). This chapter complements Font's 2008 LRR. Chapter 8 on gravitational wave extraction provides a welcome pedagogical introduction to a topic in which the original research papers are less than inviting and where notation is not uniform. The mathematical techniques described here are in constant use in numerical relativity codes, but are never fully described in research papers. Chapter 9 on numerical methods covers finite difference and high-resolution shock capturing methods. It is similar in presentation to Leveque's 1992 book and Kreiss and Busenhart's 2001 book, but gives a good selection of that material, concisely presented. It certainly impresses the importance of convergence testing on the reader. Chapter 10 covers methods for spherically symmetric and axisymmetric spacetimes. The former is excellent, reflecting the author's recent research work. The axisymmetry section would have been better if it had been based on a formal Geroch reduction, the method that has been the key to recent progress. This book is bound to become a standard text for beginning graduate students. In an overview for this audience, I would have liked to see a little more detail on null slicings and on the conformal field equations, and brief introductions to the theory of elliptic equations and to pseudo-spectral and finite element methods. One may also regret the many typographical errors. Nevertheless, this excellent book fills a real gap, and will be hard to follow.

Overall view of Mission Operations Control in Mission Control Center

NASA Image and Video Library

1969-05-18

S69-34316 (18 May 1969) --- Overall view of the Mission Operations Control Room in the Mission Control Center, Building 30, on the first day of the Apollo 10 lunar orbit mission. A color television transmission was being received from Apollo 10. This picture was made following Command and Service Module/Lunar Module/Saturn IVB (CSM/LM-S-IVB) separation and prior to LM extraction from the S-IVB. The CSM were making the docking approach to the LM/S-IVB.

Inflight - Apollo X - MSC

NASA Image and Video Library

1969-05-18

S69-34039 (18 May 1969) --- Overall view of activity in the Mission Operations Control Room in the Mission Control Center, Building 30, on the first day of the Apollo 10 lunar orbit mission. This picture was taken following CSM/LM-S-IVB separation, and prior to LM extraction from the S-IVB. The telecast from the Apollo 10's color TV camera shows the LM still attached to the S-IVB. The CSM is making the docking approach to the LM/S-IVB.

View of crater Posidonius at edge of Sea of Serenity seen by Apollo 15

NASA Image and Video Library

1971-08-01

AS15-91-12366 (31 July-2 Aug. 1971) --- The crater Posidonius at the northeastern edge of the Sea of Serenity, was photographed with a 70mm handheld Hasselblad from the Command and Service Module (CSM) by astronaut Alfred M. Worden, command module pilot, in lunar orbit. While Worden remained with the CSM in lunar orbit, astronauts David R. Scott and James B. Irwin descended in the Lunar Module (LM) "Falcon" to explore the lunar surface.

Chloride: the queen of electrolytes?

PubMed

Berend, Kenrick; van Hulsteijn, Leonard Hendrik; Gans, Rijk O B

2012-04-01

Channelopathies, defined as diseases that are caused by mutations in genes encoding ion channels, are associated with a wide variety of symptoms and have been documented extensively over the past decade. In contrast, despite the important role of chloride in serum, textbooks in general do not allocate chapters exclusively on hypochloremia or hyperchloremia and information on chloride other than channelopathies is scattered in the literature. To systematically review the function of chloride in man, data for this review include searches of MEDLINE, PubMed, and references from relevant articles including the search terms "chloride," "HCl," "chloride channel" "acid-base," "acidosis," "alkalosis," "anion gap" "strong anion gap" "Stewart," "base excess" and "lactate." In addition, internal medicine, critical care, nephrology and gastroenterology textbooks were evaluated on topics pertaining the assessment and management of acid-base disorders, including reference lists from journals or textbooks. Chloride is, after sodium, the most abundant electrolyte in serum, with a key role in the regulation of body fluids, electrolyte balance, the preservation of electrical neutrality, acid-base status and it is an essential component for the assessment of many pathological conditions. When assessing serum electrolytes, abnormal chloride levels alone usually signify a more serious underlying metabolic disorder, such as metabolic acidosis or alkalosis. Chloride is an important component of diagnostic tests in a wide array of clinical situations. In these cases, chloride can be tested in sweat, serum, urine and feces. Abnormalities in chloride channel expression and function in many organs can cause a range of disorders. Copyright © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Tensile properties of compressed moulded Napier/glass fibre reinforced epoxy composites

NASA Astrophysics Data System (ADS)

Fatinah, T. S.; Majid, M. S. Abdul; Ridzuan, M. J. M.; Hong, T. W.; Amin, N. A. M.; Afendi, M.

2017-10-01

This paper describes the experimental investigation of the tensile properties of compressed moulded Napier grass fibres reinforced epoxy composites. The effect of treatment 5% sodium hydroxide (NaOH) concentrated solution and hybridization of Napier with CSM E-glass fibres on tensile properties was also studied. The untreated and treated Napier fibres with 25% fibre loading were fabricated with epoxy resin by a cold press process. 7% fibre loading of CSM glass fibre was hybrid as the skin layer for 18% fibre loading of untreated Napier grass fibre. The tensile tests were conducted using Universal Testing Machine in accordance with ASTM D638. The tensile properties of the untreated Napier/epoxy composites were compared with treated Napier/epoxy and untreated Napier/CSM/epoxy composites. The results demonstrated that the tensile performance of untreated Napier fibre composites was significantly improved by both of the modification; alkali treatment and glass fibre hybridization. Napier grass fibres showed promising potentials to be used as reinforcement in the polymer based composites.

Islamic values in the Kuwaiti curriculum

NASA Astrophysics Data System (ADS)

Alshahen, Ghanim A.

This study investigated the influence of Islamic values on the curriculum, in particular the Islamic studies and science curricula. Three questionnaires were developed, validated, and used to investigate teachers' and pupils' attitudes toward Islamic values in the curriculum. Four main sections deal with Islamic values in the Islamic studies and science curricula, namely: Islamic values in the textbook, teaching Islamic values, the relationship between Islamic values and the science curriculum, and the Islamic values model. Two instruments were used in this study: questionnaires and interviews. Both qualitative and quantitative data were generated from the sample, which consisted of Islamic studies and science teachers and supervisors in intermediate schools, and pupils studying in the eighth grade in intermediate schools. In the last case, the data were gathered by questionnaire only. The interviews and questionnaires provided explanatory data. The research was carried out in three phases, considering respectively 55 Islamic studies teachers, 55 science teachers who teach the eighth grade in intermediate schools, and 786 pupils who study in the eighth grade in 20 schools. In each school, the researcher selected two classes. This thesis consists of eight chapters. Chapter One provides a general introduction and highlights the general framework of this study. Chapter Two is concerned with the development of the education system in Kuwait and the objectives of the Islamic studies and science curricula in the intermediate stage. Chapter Three presents the conceptions of values, the Islamic values model, and Islamic values in the curriculum. Chapter Four describes the objectives of the study, and its research design methods and procedures used to develop the instruments. The sampling procedure, the data collection procedures, and the statistical methods used to analyse the data are also described. Chapter Five presents and interprets the findings of this study. Data analysis in this chapter deals with the Islamic studies and science teachers' questionnaires and both the teachers' and supervisors' interviews. The interview findings are dealt with according to the key themes. Chapter Seven discusses the main findings related to Islamic values in both curricula. Chapter Eight reflects on the main themes of the investigation as a whole. It gives a brief description of the aims and methods of the study and sets out the major findings, their importance, and limitations. Finally, the study concludes with several recommendations and suggestions for developing Islamic values in the curriculum.

Cervical Spondylotic Myelopathy presenting as mechanical neck pain: a case report.

PubMed

Smith, Benjamin E; Diver, Claire J; Taylor, Alan J

2014-08-01

Cervical Spondylotic Myelopathy (CSM) is the most common type of myelopathy in adults over 55 years of age. In the early stages symptoms may include local neck pain and stiffness that might mimic the presentation of non-specific mechanical neck pain (NSMNP). The patient was a 79 year old male, who complained of eight weeks of neck pain. He had been referred for physiotherapy by his family physician with a diagnosis of NSMNP. Initial presentation was consistent with the referral, but further assessment by the physiotherapist revealed findings suggestive of CSM. He was referred for an urgent cervical MRI scan, which revealed myelomalacic changes at C3/4 due to spondylotic changes. The patient was unsuitable for manual therapy intervention and was referred to a spinal orthopaedic surgeon who performed a posterior decompression and stabilisation at C3-C5, 2 months after the initial presentation. This case report highlights the importance of considering CSM in adults over 55 years of age presenting with NSMNP, particularly as the prevalence of both increases with age. It demonstrates the need for health professionals to carry out detailed examination where CSM may be a potential differential diagnosis. Outcomes are less favourable for patients over the age of 70, therefore an urgent surgical opinion was required for this patient. Deterioration of symptoms whilst he awaited surgery demonstrates how missed diagnosis may lead to possible long term spinal cord damage, with potential medico-legal concerns for the therapist. Copyright © 2014 Elsevier Ltd. All rights reserved.

Applying a health behavior theory to explore the influence of information and experience on arsenic risk representations, policy beliefs, and protective behavior.

PubMed

Severtson, Dolores J; Baumann, Linda C; Brown, Roger L

2006-04-01

The common sense model (CSM) shows how people process information to construct representations, or mental models, that guide responses to health threats. We applied the CSM to understand how people responded to information about arsenic-contaminated well water. Constructs included external information (arsenic level and information use), experience (perceived water quality and arsenic-related health effects), representations, safety judgments, opinions about policies to mitigate environmental arsenic, and protective behavior. Of 649 surveys mailed to private well users with arsenic levels exceeding the maximum contaminant level, 545 (84%) were analyzed. Structural equation modeling quantified CSM relationships. Both external information and experience had substantial effects on behavior. Participants who identified a water problem were more likely to reduce exposure to arsenic. However, about 60% perceived good water quality and 60% safe water. Participants with higher arsenic levels selected higher personal safety thresholds and 20% reported a lower arsenic level than indicated by their well test. These beliefs would support judgments of safe water. A variety of psychological and contextual factors may explain judgments of safe water when information suggested otherwise. Information use had an indirect effect on policy beliefs through understanding environmental causes of arsenic. People need concrete information about environmental risk at both personal and environmental-systems levels to promote a comprehensive understanding and response. The CSM explained responses to arsenic information and may have application to other environmental risks.

Comparison of Functional and Radiological Outcomes Between Two Posterior Approaches in the Treatment of Multilevel Cervical Spondylotic Myelopathy

PubMed Central

Ren, Da-Jiang; Li, Fang; Zhang, Zhi-Cheng; Kai, Guan; Shan, Jian-Lin; Zhao, Guang-Min; Sun, Tian-Sheng

2015-01-01

Background: Posterior cervical decompression is an accepted treatment for multilevel cervical spondylotic myelopathy (CSM). Each posterior technique has its own advantages and disadvantages. In the present study, we compared the functional and radiological outcomes of expansive hemilaminectomy and laminoplasty with mini titanium plate in the treatment of multilevel CSM. Methods: Forty-four patients with multilevel CSM treated with posterior cervical surgery in Department of Orthopedic Surgery, Beijing Army General Hospital from March 2011 to June 2012 were enrolled in this retrospective study. Patients were divided into two groups by surgical procedure: Laminoplasty (Group L) and hemilaminectomy (Group H). Perioperative parameters including age, sex, duration of symptoms, operative duration, and intraoperative blood loss were recorded and compared. Spinal canal area, calculated using AutoCAD® software (Autodesk Inc., San Rafael, CA, USA), and neurological improvement, evaluated with Japanese Orthopedic Association score, were also compared. Results: Neurological improvement did not differ significantly between groups. Group H had a significantly shorter operative duration and significantly less blood loss. Mean expansion ratio was significantly greater in Group L (77.83 ± 6.41%) than in Group H (62.72 ± 3.86%) (P < 0.01). Conclusions: Both surgical approaches are safe and effective in treating multilevel CSM. Laminoplasty provides a greater degree of enlargement of the spinal canal, whereas expansive hemilaminectomy has the advantages of shorter operative duration and less intraoperative blood loss. PMID:26228218

Statistical monitoring of data quality and consistency in the Stomach Cancer Adjuvant Multi-institutional Trial Group Trial.

PubMed

Timmermans, Catherine; Doffagne, Erik; Venet, David; Desmet, Lieven; Legrand, Catherine; Burzykowski, Tomasz; Buyse, Marc

2016-01-01

Data quality may impact the outcome of clinical trials; hence, there is a need to implement quality control strategies for the data collected. Traditional approaches to quality control have primarily used source data verification during on-site monitoring visits, but these approaches are hugely expensive as well as ineffective. There is growing interest in central statistical monitoring (CSM) as an effective way to ensure data quality and consistency in multicenter clinical trials. CSM with SMART™ uses advanced statistical tools that help identify centers with atypical data patterns which might be the sign of an underlying quality issue. This approach was used to assess the quality and consistency of the data collected in the Stomach Cancer Adjuvant Multi-institutional Trial Group Trial, involving 1495 patients across 232 centers in Japan. In the Stomach Cancer Adjuvant Multi-institutional Trial Group Trial, very few atypical data patterns were found among the participating centers, and none of these patterns were deemed to be related to a quality issue that could significantly affect the outcome of the trial. CSM can be used to provide a check of the quality of the data from completed multicenter clinical trials before analysis, publication, and submission of the results to regulatory agencies. It can also form the basis of a risk-based monitoring strategy in ongoing multicenter trials. CSM aims at improving data quality in clinical trials while also reducing monitoring costs.

BOOK REVIEW: Introduction to Plasma Physics: With Space and Laboratory Applications

NASA Astrophysics Data System (ADS)

Browning, P. K.

2005-07-01

A new textbook on plasma physics must be very welcome, as this will encourage the teaching of courses on the subject. This book is written by two experts in their fields, and is aimed at advanced undergraduate and postgraduate courses. There are of course many other plasma physics textbooks available. The niche which this particular book fills is really defined by its subtitle: that is, `with space and laboratory applications'. This differs from most other books which tend to emphasise either space or fusion applications (but not both) or to concentrate only on general theory. Essentially, the emphasis here is on fundamental plasma physics theory, but applications are given from time to time. For example, after developing Alfvén wave theory, observations of Alfvén waves in the solar wind and in the Jovian magnetosphere are presented; whilst ion acoustic cylcotron waves are illustrated by data from a laboratory Q machine. It is fair to say that examples from space seem to predominate. Nevertheless, the approach of including a broad range of applications is very good from an educational point of view, and this should help to train a generation of students with a grasp of fundamental plasma physics who can work in a variety of research fields. The subject coverage of the book is fairly conventional and there are no great surprises. It begins, inevitably, with a discussion of plasma parameters (Debye length etc) and of single particle motions. Both kinetic theory and magnetohydrodynamics are introduced. Waves are quite extensively discussed in several chapters, including both cold and hot plasmas, magnetised and unmagnetised. Nonlinear effects—a large subject!—are briefly discussed. A final chapter deals with collisions in fully ionised plasmas. The choice of contents of a textbook is always something of a matter of personal choice. It is easy to complain about what has been left out, and everyone has their own favourite topics. With that caveat, I would question whether the rather heavy emphasis on waves is optimal. Newcomers to plasma physics could be left with the impression that plasma physics is mainly a collection of dispersion relations. On the other hand, there is almost no mention of two fluid theory, surely an important subject. Topics relevant to fusion edge plasmas, a subject of growing research interest, are not mentioned at all (for example, sheath theory; also partially ionised plasmas, which are also of course very relevant in space applications). And I am surprised that the discussion of MHD stability does not even mention the kink instability, which is of primary importance both in fusion and solar plasmas. The book is clearly set out and easy to read. Diagrams are clear and helpful. Derivations are properly explained, without leaving too many missing steps. From the point of view of a textbook, it is useful that not too much mathematical knowledge is assumed; for example, when it is needed, the theory of Laplace transforms is explained. A nice feature—very important for a text book—is the presence of end-of-chapter problems. These will be very useful for both students and teachers! It is also good that each chapter has a comprehensive list of references, which might be used to direct more advanced students to the up-to-date scientific literature, as well as suggestions for further reading. Although the primary emphasis is on standard, `classical' plasma physics, a good attempt is made to present more recent aspects of the subject. For example, after presenting the standard theory of particle orbits—which usefully includes a discussion of Hamiltonian theory as well as guiding centre theory—there is an introduction to the topic of chaotic orbits. Such material is important from an educational point of view, so that from the very beginning students are made aware that plasma physics is a living subject. Overall, this is a very useful addition to the literature. I would recommend it for adoption as a course text for those teaching courses in plasma physics. It would also be a useful book for reference or self study for those working in the field, particularly new postgraduate students.

3+4 = 6? Implications of the stratification of localised Gleason 7 prostate cancer by number and percentage of positive biopsy cores in selecting patients for active surveillance.

PubMed

Ruiz-Cerdá, J L; Lorenzo Soriano, L; Ramos-Soler, D; Marzullo-Zucchet, L; Loras Monfort, A; Boronat Tormo, F

2018-03-01

To determine whether the number and percentage of positive biopsy cores identify a Gleason 3+4 prostate cancer (PC) subgroup of similar biologic behaviour to Gleason 3+3. An observational post-radical prostatectomy study was conducted of a cohort of 799 patients with localised low-risk (n=582, Gleason 6, PSA <10ng/ml and cT1c-2a) and favourable intermediate PC (n=217, Gleason 3+4, PSA ≤10 ng/ml and pT2abc). The Gleason 3+4 tumours were stratified by number (≤3 vs.>3) and by percentage of positive cores (≤33% vs. >33%). We analysed the tumours' association with the biochemical recurrence risk (BRR) and cancer-specific mortality (CSM). We conducted various predictive models using Cox regression and estimated (C-index) and compared their predictive capacity. With a median follow-up of 71 months, the BRR and CSM of the patient group with Gleason 3+4 tumours and a low number (≤3) and percentage (≤33%) of positive cores were not significantly different from those of the patients with Gleason 6 tumours. At 5 and 10 years, there were no significant differences in the number of biochemical recurrences, the probability of remaining free of biochemical recurrences, the number of deaths by PC or the probability of death by PC between the 2 groups. In contrast, the patients with Gleason 3+4 tumours and more than 33% of positive cores presented more deaths by PC than the patients with Gleason 6 tumours. At 10 years, the probability of CSM was significantly greater. This subgroup of tumours showed a significantly greater BRR (RR, 1.6; P=.02) and CSM (RR, 5.8, P≤.01) compared with the Gleason 6 tumours. The model with Gleason 3+4 stratified by the percentage of positive cores significantly improved the predictive capacity of BRR and CSM. Fewer than 3 cores and a percentage <33% of positive cores identifies a subgroup of Gleason 3+4 tumours with biological behaviour similar to Gleason 6 tumours. At 10 years, there were no differences in BRR and CSM between the 2 groups. These results provide evidence supporting active surveillance as an alternative for Gleason 3+4 tumours and low tumour extension in biopsy. Copyright © 2017 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

Cosmic Rays in the Earth's Atmosphere and Underground

NASA Astrophysics Data System (ADS)

Dorman, Lev I.

2004-08-01

This book consists of four parts. In the first part (Chapters 1-4) a full overview is given of the theoretical and experimental basis of Cosmic Ray (CR) research in the atmosphere and underground for Geophysics and Space Physics; the development of CR research and a short history of many fundamental discoveries, main properties of primary and secondary CR, methods of transformation of CR observation data in the atmosphere and underground to space, and the experimental basis of CR research underground and on the ground, on balloons and on satellites and space probes. The second part (Chapters 5-9) is devoted to the influence of atmospheric properties on CR, so called CR meteorological effects; pressure, temperature, humidity, snow, wind, gravitation, and atmospheric electric field effects. The inverse problem - the influence of CR properties on the atmosphere and atmospheric processes is considered in the third part (Chapters 10-14); influence on atmospheric, nuclear and chemical compositions, ionization and radio-wave propagation, formation of thunderstorms and lightning, clouds and climate change. The fourth part (Chapters 15-18) describes many realized and potential applications of CR research in different branches of Science and Technology; Meteorology and Aerodrome Service, Geology and Geophysical Prospecting, Hydrology and Agricultural Applications, Archaeology and Medicine, Seismology and Big Earthquakes Forecasting, Space Weather and Environment Monitoring/Forecasting. The book ends with a list providing more than 1,500 full references, a discussion on future developments and unsolved problems, as well as object and author indices. This book will be useful for experts in different branches of Science and Technology, and for students to be used as additional literature to text-books.

Book Review: Reconstructing Quaternary Environments

NASA Astrophysics Data System (ADS)

Bridgland, David R.; Evans, David J. A.; Roberts, David H.

2016-02-01

A third edition of this, the foremost Quaternary textbook, is most welcome, coming seventeen years after the 1997 second edition (which was 13 years after the first). The general impression is one of advancement, not least because of the extensive updating of literature cited and examples used, with the status maintained of an impressive compendium of a specialism with a very wide subject base. Some changes are cosmetic, with chapter and section headers having a more modern style and a profusion of new colour photographs and diagrams. Some of the latter are redrawn from black and white figures in the previous edition, although not all have been improved, as some are smaller and have been simplified. For example, black and white Fig. 3.10 of the Second Edition compares very favourably with the much smaller colour 3.17 in this latest volume (erratic sources). On the plus side, the number change, for a figure that appears in the same place within the chapter, shows that the latest edition is considerably better illustrated than its predecessor, perhaps accounting for a significant proportion of the increased page total (up from 446 to 538).

Apollo 11 Mission image - CSM over the Sea of Tranquility

NASA Image and Video Library

1969-07-20

AS11-37-5448 (July 1969) --- The Apollo 11 Command and Service Modules (CSM) (tiny dot near quarter sized crater, center), with astronaut Michael Collins, command module pilot, aboard. The view overlooking the western Sea of Tranquility was photographed from the Lunar Module (LM). Astronauts Neil A. Armstrong, commander, and Edwin E. Aldrin Jr., lunar module pilot, manned the LM and made their historic lunar landing on July 20, 1969. Coordinates of the center of the terrain in the photograph are 18.5 degrees longitude and .5 degrees north latitude.

Thermomechanical CSM analysis of a superheater tube in transient state

NASA Astrophysics Data System (ADS)

Taler, Dawid; Madejski, Paweł

2011-12-01

The paper presents a thermomechanical computational solid mechanics analysis (CSM) of a pipe "double omega", used in the steam superheaters in circulating fluidized bed (CFB) boilers. The complex cross-section shape of the "double omega" tubes requires more precise analysis in order to prevent from failure as a result of the excessive temperature and thermal stresses. The results have been obtained using the finite volume method for transient state of superheater. The calculation was carried out for the section of pipe made of low-alloy steel.

Fires. July-September 08

DTIC Science & Technology

2008-07-01

4, we find the addition of C2 warfare (C2W) and nonlethal fires integration to the fires F ire Support is hard, especially if you are stupid.” A...he presented the “Status of the Field Artillery” and the “FA Campaign Plan” during the Fires Seminar a t F o r t Sill, Okla- homa , in June. Why...excellence, at Fort sill, Okla- homa . He served as the Battalion csM of 1st Battalion, 22nd Field Artillery (1-22 FA), 434th FA Brigade, Fort sill; csM of

Book Reviews

NASA Astrophysics Data System (ADS)

Horner, Joseph L.

1987-04-01

Progress in the fields of integrated optics and fiber optics is continuing at a rapid pace. Recognizing this trend, the goal of the author is to provide an introductory textbook on time-harmonic electromagnetic theory, with an emphasis on optical rather than microwave technologies. The book is appropriate for an upper-level undergraduate or graduate course. Each chapter includes examples of problems. The book focuses on several areas of prime importance to intergrated optics. These include dielectric waveguide analysis, couple-mode thoery, Bragg scattering, and prism coupling There is very little coverage of active components such as electro-optic modulators and switches. The author assumes the reader has a working knowledge of vector calculus and is familiar with Maxwell's equations.

Functional outcome instruments used for cervical spondylotic myelopathy: interscale correlation and prediction of preference-based quality of life.

PubMed

Whitmore, Robert G; Ghogawala, Zoher; Petrov, Dmitriy; Schwartz, J Sanford; Stein, Sherman C

2013-08-01

There is limited literature comparing different functional outcome measures used for cervical spondylotic myelopathy (CSM). To determine the correlation among five functional outcome measures used in CSM patient assessment and their ability to predict preference-based quality of life (QOL). Prospective observational study. Patients, aged 40 to 85 years, with CSM and cervical spinal cord compression at two or more levels from degenerative spondylosis were enrolled from seven sites over a 2-year period. The modified Japanese Orthopedic Association scale, Oswestry neck disability index (Oswestry NDI or Oswestry), Nurick scale, norm-based short-form 36 physical component summary, and EuroQol-5D (EQ-5D) were collected. The Jean and David Wallace foundation provided funding for this study. Cervical spondylotic myelopathy patients undergoing either anterior or posterior surgery were prospectively followed with five different functional outcome measures over 1 year. Correlations among scales were tested using the Spearman rank correlation test. The sensitivity and specificity of each scale for predicting the global index of the EQ-5D were determined, and receiver-operating characteristic analysis was used to compare each scale's ability to discriminate QOL. A total of 106 patients were initially enrolled; 103 were operated on for CSM and followed for 1 year. Their ages ranged from 40 to 82 years (mean 61.9), and 61.3% were men. Correlations among the various functional outcome instruments were all highly significant (p<.001), but the degree of correlation varied greatly. Correlation between the EQ-5D scale and the Nurick scale was the least (Spearman rho 0.5539); correlation was the highest with the Oswestry NDI (Spearman rho 0.8306). The Oswestry NDI also had the greatest ability to discriminate favorable from adverse QOL compared with the other outcome instruments (p=.023). Preference-based quality-of-life instruments, such as the EQ-5D, are important measures for studying spinal disorders. Among the various commonly used outcome instruments for CSM, the Oswestry NDI is the most predictive of preference-based QOL. Copyright © 2013 Elsevier Inc. All rights reserved.

Bumpy light curves of interacting supernovae

NASA Astrophysics Data System (ADS)

Nyholm, Anders

2017-04-01

A supernova (SN) is the explosive destruction of a star. Via a luminous outpouring of radiation, the SN can rival the brightness of its SN host galaxy for months or years. In the past decade, astronomical surveys regularly observing the sky to deep limiting magnitudes have revealed that core collapse SNe (the demises of massive stars) are sometimes preceded by eruptive episodes by the progenitor stars during the years before the eventual SN explosion. Such SNe tend to show strong signatures of interaction between the SN ejecta and the circumstellar medium (CSM) deposited by the star before the SN explosion, likely by mass-loss episodes like the ones we have started to observe regularly. The complex CSM resolved around certain giant stars in our own galaxy and the eruptions of giant stars like Eta Carinae in the 19th century can be seen in this context. As the SN ejecta of an interacting SN sweep up the CSM of the progenitor, radiation from this process offers observers opportunity to scan the late mass loss history of the progenitor. In this thesis, interacting SNe and eruptive mass loss of their progenitors is discussed. The SN iPTF13z (discovered by the intermediate Palomar Transient Factory, iPTF) is presented. This transient was followed with optical photometry and spectroscopy during 1000 days and displayed a light curve with several conspicuous re-brigthenings ("bumps"), likely arising from SN ejecta interacting with denser regions in the CSM. Around 200 days before discovery, in archival data we found a clear precursor outburst lasting ∼50 days. A well-observed (but not necessarily well understood) event like SN 2009ip, which showed both precursor outbursts and a light curve bump, makes an interesting comparison object. The embedding of the (possible) SN in a CSM makes it hard to tell if a destructive SN explosion actually happened. In this respect, iPTF13z is compared to e.g. SN 2009ip but also to long-lived interacting SNe like SN 1988Z. Some suggestions for future investigations are offered, to tie light curve bumps to precursor events and to clarify the question of core collapse in the ambiguous cases of some interacting SNe.

Fully automated corneal endothelial morphometry of images captured by clinical specular microscopy

NASA Astrophysics Data System (ADS)

Bucht, Curry; Söderberg, Per; Manneberg, Göran

2009-02-01

The corneal endothelium serves as the posterior barrier of the cornea. Factors such as clarity and refractive properties of the cornea are in direct relationship to the quality of the endothelium. The endothelial cell density is considered the most important morphological factor. Morphometry of the corneal endothelium is presently done by semi-automated analysis of pictures captured by a Clinical Specular Microscope (CSM). Because of the occasional need of operator involvement, this process can be tedious, having a negative impact on sampling size. This study was dedicated to the development of fully automated analysis of images of the corneal endothelium, captured by CSM, using Fourier analysis. Software was developed in the mathematical programming language Matlab. Pictures of the corneal endothelium, captured by CSM, were read into the analysis software. The software automatically performed digital enhancement of the images. The digitally enhanced images of the corneal endothelium were transformed, using the fast Fourier transform (FFT). Tools were developed and applied for identification and analysis of relevant characteristics of the Fourier transformed images. The data obtained from each Fourier transformed image was used to calculate the mean cell density of its corresponding corneal endothelium. The calculation was based on well known diffraction theory. Results in form of estimated cell density of the corneal endothelium were obtained, using fully automated analysis software on images captured by CSM. The cell density obtained by the fully automated analysis was compared to the cell density obtained from classical, semi-automated analysis and a relatively large correlation was found.

Flash Spectroscopy: Emission Lines From the Ionized Circumstellar Material Around 10-Day-Old Type II Supernovae

NASA Technical Reports Server (NTRS)

Khazov, D.; Yaron, O.; Gal-Yam, A.; Manulis, I.; Rubin, A.; Kulkarni, S. R.; Arcavi, I.; Kasliwal, M. M.; Ofek, E. O.; Cao, Y.;

What powers the 3000-day light curve of SN 2006gy?

DOE PAGES

Fox, Ori D.; Smith, Nathan; Ammons, S. Mark; ...

2015-10-27

SN 2006gy was the most luminous supernova (SN) ever observed at the time of its discovery and the first of the newly defined class of superluminous supernovae (SLSNe). The extraordinary energetics of SN 2006gy and all SLSNe (>10 51 erg) require either atypically large explosion energies (e.g. pair-instability explosion) or the efficient conversion of kinetic into radiative energy (e.g. shock interaction). The mass-loss characteristics can therefore offer important clues regarding the progenitor system. For the case of SN 2006gy, both a scattered and thermal light echo from circumstellar material (CSM) have been reported at later epochs (day ~800), ruling outmore » the likelihood of a pair-instability event and leading to constraints on the characteristics of the CSM. Owing to the proximity of the SN to the bright host-galaxy nucleus, continued monitoring of the light echo has not been trivial, requiring the high resolution offered by the Hubble Space Telescope ( HST) or ground-based adaptive optics (AO). Furthermore, we report detections of SN 2006gy using HST and Keck AO at ~3000 d post-explosion and consider the emission mechanism for the very late-time light curve. While the optical light curve and optical spectral energy distribution are consistent with a continued scattered-light echo, a thermal echo is insufficient to power the K'-band emission by day 3000. Instead, we present evidence for late-time infrared emission from dust that is radiatively heated by CSM interaction within an extremely dense dust shell, and we consider the implications on the CSM characteristics and progenitor system.« less

What powers the 3000-day light curve of SN 2006gy?

NASA Astrophysics Data System (ADS)

Fox, Ori D.; Smith, Nathan; Ammons, S. Mark; Andrews, Jennifer; Bostroem, K. Azalee; Cenko, S. Bradley; Clayton, Geoffrey C.; Dwek, Eli; Filippenko, Alexei V.; Gallagher, Joseph S.; Kelly, Patrick L.; Mauerhan, Jon C.; Miller, Adam A.; Van Dyk, Schuyler D.

2015-12-01

SN 2006gy was the most luminous supernova (SN) ever observed at the time of its discovery and the first of the newly defined class of superluminous supernovae (SLSNe). The extraordinary energetics of SN 2006gy and all SLSNe (>1051 erg) require either atypically large explosion energies (e.g. pair-instability explosion) or the efficient conversion of kinetic into radiative energy (e.g. shock interaction). The mass-loss characteristics can therefore offer important clues regarding the progenitor system. For the case of SN 2006gy, both a scattered and thermal light echo from circumstellar material (CSM) have been reported at later epochs (day ˜800), ruling out the likelihood of a pair-instability event and leading to constraints on the characteristics of the CSM. Owing to the proximity of the SN to the bright host-galaxy nucleus, continued monitoring of the light echo has not been trivial, requiring the high resolution offered by the Hubble Space Telescope (HST) or ground-based adaptive optics (AO). Here, we report detections of SN 2006gy using HST and Keck AO at ˜3000 d post-explosion and consider the emission mechanism for the very late-time light curve. While the optical light curve and optical spectral energy distribution are consistent with a continued scattered-light echo, a thermal echo is insufficient to power the K'-band emission by day 3000. Instead, we present evidence for late-time infrared emission from dust that is radiatively heated by CSM interaction within an extremely dense dust shell, and we consider the implications on the CSM characteristics and progenitor system.

Subjective versus objective evening chronotypes in bipolar disorder.

PubMed

Gershon, Anda; Kaufmann, Christopher N; Depp, Colin A; Miller, Shefali; Do, Dennis; Zeitzer, Jamie M; Ketter, Terence A

2018-01-01

Disturbed sleep timing is common in bipolar disorder (BD). However, most research is based upon self-reports. We examined relationships between subjective versus objective assessments of sleep timing in BD patients versus controls. We studied 61 individuals with bipolar I or II disorder and 61 healthy controls. Structured clinical interviews assessed psychiatric diagnoses, and clinician-administered scales assessed current mood symptom severity. For subjective chronotype, we used the Composite Scale of Morningness (CSM) questionnaire, using original and modified (1, ¾, ⅔, and ½ SD below mean CSM score) thresholds to define evening chronotype. Objective chronotype was calculated as the percentage of nights (50%, 66.7%, 75%, or 90% of all nights) with sleep interval midpoints at or before (non-evening chronotype) vs. after (evening chronotype) 04:15:00 (4:15:00a.m.), based on 25-50 days of continuous actigraph data. BD participants and controls differed significantly with respect to CSM mean scores and CSM evening chronotypes using modified, but not original, thresholds. Groups also differed significantly with respect to chronotype based on sleep interval midpoint means, and based on the threshold of 75% of sleep intervals with midpoints after 04:15:00. Subjective and objective chronotypes correlated significantly with one another. Twenty-one consecutive intervals were needed to yield an evening chronotype classification match of ≥ 95% with that made using the 75% of sleep intervals threshold. Limited sample size/generalizability. Subjective and objective chronotype measurements were correlated with one another in participants with BD. Using population-specific thresholds, participants with BD had a later chronotype than controls. Copyright © 2017 Elsevier B.V. All rights reserved.

Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations.

PubMed

Tessier, C; Sweers, K; Frajerman, A; Bergaoui, H; Ferreri, F; Delva, C; Lapidus, N; Lamaziere, A; Roiser, J P; De Hert, M; Nuss, P

2016-10-04

Schizophrenia is a severe mental condition in which several lipid abnormalities-either structural or metabolic-have been described. We tested the hypothesis that an abnormality in membrane lipid composition may contribute to aberrant dopamine signaling, and thereby symptoms and cognitive impairment, in schizophrenia (SCZ) patients. Antipsychotic-medicated and clinically stable SCZ outpatients (n=74) were compared with matched healthy subjects (HC, n=40). A lipidomic analysis was performed in red blood cell (RBC) membranes examining the major phospholipid (PL) classes and their associated fatty acids (FAs). Clinical manifestations were examined using the positive and negative syndrome scale (PANSS). Cognitive function was assessed using the Continuous Performance Test, Salience Attribution Test and Wisconsin Card Sorting Test. Sphingomyelin (SM) percentage was the lipid abnormality most robustly associated with a schizophrenia diagnosis. Two groups of patients were defined. The first group (SCZ c/SM-) is characterized by a low SM membrane content. In this group, all other PL classes, plasmalogen and key polyunsaturated FAs known to be involved in brain function, were significantly modified, identifying a very specific membrane lipid cluster. The second patient group (SCZ c/SM+) was similar to HCs in terms of RBC membrane SM composition. Compared with SCZ c/SM+, SCZ c/SM- patients were characterized by significantly more severe PANSS total, positive, disorganized/cognitive and excited psychopathology. Cognitive performance was also significantly poorer in this subgroup. These data show that a specific RBC membrane lipid cluster is associated with clinical and cognitive manifestations of dopamine dysfunction in schizophrenia patients. We speculate that this membrane lipid abnormality influences presynaptic dopamine signaling.

Facility design, construction, and operation

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

France has been disposing of low-level radioactive waste (LLW) at the Centre de Stockage de la Manche (CSM) since 1969 and now at the Centre de Stockage de l`Aube (CSA) since 1992. In France, several agencies and companies are involved in the development and implementation of LLW technology. The Commissariat a l`Energie Atomic (CEA), is responsible for research and development of new technologies. The Agence National pour la Gestion des Dechets Radioactifs is the agency responsible for the construction and operation of disposal facilities and for wastes acceptance for these facilities. Compagnie Generale des Matieres Nucleaires provides fuel services, includingmore » uranium enrichment, fuel fabrication, and fuel reprocessing, and is thus one generator of LLW. Societe pour les Techniques Nouvelles is an engineering company responsible for commercializing CEA waste management technology and for engineering and design support for the facilities. Numatec, Inc. is a US company representing these French companies and agencies in the US. In Task 1.1 of Numatec`s contract with Martin Marietta Energy Systems, Numatec provides details on the design, construction and operation of the LLW disposal facilities at CSM and CSA. Lessons learned from operation of CSM and incorporated into the design, construction and operating procedures at CSA are identified and discussed. The process used by the French for identification, selection, and evaluation of disposal technologies is provided. Specifically, the decisionmaking process resulting in the change in disposal facility design for the CSA versus the CSM is discussed. This report provides` all of the basic information in these areas and reflects actual experience to date.« less

BOOK REVIEW: A First Course in General Relativity (Second Edition) A First Course in General Relativity (Second Edition)

NASA Astrophysics Data System (ADS)

Poisson, Eric

2010-05-01

A few years ago, in my review of Sean Carroll's book in Classical and Quantum Gravity [1], I wrote that while the 1970s was the decade of Weinberg [2] and Misner, Thorne and Wheeler [3], and while the eighties was the decade of Schutz [4] and Wald [5], the 2000s was clearly the decade of Hartle [6] and Carroll [7]. In my opinion, these books continue to stand out in the surprisingly dense crowd of introductory textbooks on general relativity. At the dawn of this new decade I look forward to see what fresh pedagogical insights will be produced next, and who will be revealed as the winners of the 2010s. It is, of course, much too early to tell, but Schutz is back, and he will set the standard just as he did back in 1985. This is the long-awaited second edition of his `First Course', a short, accessible, and very successful introduction to general relativity. The changes from the first edition are modest: Schutz wisely refrained from bloating the text with new topics, and limited himself to updating his discussion of gravitational-wave sources and detectors, neutron-star and black-hole astrophysics, and suggestions for further reading. Most importantly, he completely rewrote the chapter on cosmology, a topic that has evolved enormously since the first edition. The book begins in chapter 1 with a beautiful review of special relativity that emphasizes spacetime geometry and stays away from an algebraic approach based on the Lorentz transformation, which appears only later in the chapter. This is followed up in chapters 2 and 3 with an introduction to vector and tensor analysis in flat spacetime. The point of view is modern (tensors are defined as linear mapping of vectors and one-forms into real numbers) but the presentation is very accessible and avoids an overload of mathematical fine print. In chapter 4 the book introduces the spacetime description of fluids; it is here that the energy-momentum tensor makes its first appearance. The move to curved spacetime is tackled next. In chapter 5 the principle of equivalence is used to motivate the notion that gravity is a manifestation of spacetime curvature. Tensor calculus in curved spacetime is approached gently, by first working through a generalization to curvilinear coordinates. A systematic introduction to differential geometry is provided in chapter 6; here the reader is initiated in Riemannian manifolds, covariant differentiation, parallel transport, geodesics, the curvature tensors, and the Bianchi identities. This is a formidable chapter, but the student is guided by a sure hand, and the presentation is both beautiful and accessible. The next two chapters bring differential geometry to physics. In chapter 7 the reader learns how to formulate the laws of physics in a curved spacetime, and in chapter 8 the Einstein field equations are finally formulated. The chapter ends with a thorough treatment of the weak-field limit in the Lorenz gauge. The following chapters present applications of the theory. Chapter 9 is devoted to gravitational waves: propagation, detection, generation, energy balance, and astrophysical sources. Here, as always, the discussion is accessible and fully up-to-date. I could identify one weakness, which I have noted in many other textbooks (this is a pet peeve of mine, which seems to be turning into an obsession): the quadrupole formula for the gravitational-wave field is derived on the basis of the linearized theory, without warning the reader that the derivation does not apply to self-gravitating systems. This is, however, compensated by a major strength: Schutz's derivation of the energy carried off by gravitational waves is based on a beautiful physical argument that bypasses the construction of an energy-momentum tensor for the gravitational-wave field; the complexities associated with such a construction are well known, and it is nice to see that Schutz has found a nice way around. In chapter 10 the exact theory is applied to stellar structure, and in chapter 11 the student is introduced to black holes. A large part of the chapter is devoted to the study of geodesic motion in Schwarzschild spacetime, and this allows Schutz to make contact with the classical tests of general relativity: perihelion advance and light deflection. The singular behaviour of the Schwarzschild coordinates at the event horizon is described in detail. This reveals another weakness of the book: the Kruskal coordinates are simply written down, with no derivation and little motivation; it is a pity that Schutz did not choose to introduce the Eddington--Finkelstein coordinates, or the Painlevé-Gullstand coordinates, as easier alternatives. The chapter ends with a general discussion of black holes (including their place in astrophysics and a description of the Hawking effect) and a detailed presentation of the Kerr solution. The last chapter (chapter 12) is devoted to cosmology, and this is the part of the book that was the most thoroughly revised. The presentation begins with the enunciation of the cosmological principle and a derivation of the Friedmann-Lemaitre models. It continues with a discussion of cosmological dynamics in the presence of pressureless matter, radiation, and a cosmological constant (of which nobody wanted to be reminded at the time of the first edition). It concludes with an up-to-date review of cosmological measurements and a (very) brief history of the Universe, from the big bang to inflation, to recombination, to structure formation. The presentation of general relativity and its applications contained in this book is suitable for undergraduate students who would prefer the standard `math-first approach' to Hartle's `physics-first approach'. The student will learn the essentials of differential geometry in a gentle way, and will then apply these tools to physics in curved spacetime; all of this can be accomplished in a brisk one-semester course. The book leaves out many topics than can be found in more advanced texts, such as Lie differentiation, differential forms, Killing vectors, the more abstract formulation of differential geometry (in terms of charts and diffeomorphisms), and the Lagrangian formulation of general relativity. This limitation of scope is wise: Schutz masterly covers the essentials in an efficient and small package, and relegates all refinements to further reading in other textbooks; this is a sound learning strategy. To conclude I will state that I just love this book. I love it today as much as I did when I first came across it as an undergraduate student. The revisions bring the book up-to-date, and they ensure that Schutz's text will remain in the pantheon of introductory general relativity books for many years to come. References [1] Poisson E 2005 Review of Spacetime and Geometry: An Introduction to General Relativity, by S M Carroll Class. Quantum Grav. 22 4385-4386 [2] Weinberg S 1972 Gravitation and Cosmology: Principles and Applications of the General Theory of Relativity (New York: Wiley) [3] Misner C W, Thorne K S, and Wheeler J A 1973 Gravitation (San Francisco, CA: Freeman) [4] Schutz B F 1985 A First Course in General Relativity (Cambridge: Cambridge University Press) [5] Wald R M 1984 General Relativity (Chicago : Chicago University Press) [6] Hartle J B 2003 Gravity: An Introduction to Einstein's General Relativity (San Francisco, CA: Addison-Wesley) [7] Carroll S 2003 Spacetime and Geometry: An Introduction to General Relativity (San Francisco, CA: Benjamin Cummings)

Desegregating undergraduate mathematics and biology--interdisciplinary instruction with emphasis on ongoing biomedical research.

PubMed

Robeva, Raina

2009-01-01

The remarkable advances in the field of biology in the last decade, specifically in the areas of biochemistry, genetics, genomics, proteomics, and systems biology, have demonstrated how critically important mathematical models and methods are in addressing questions of vital importance for these disciplines. There is little doubt that the need for utilizing and developing mathematical methods for biology research will only grow in the future. The rapidly increasing demand for scientists with appropriate interdisciplinary skills and knowledge, however, is not being reflected in the way undergraduate mathematics and biology courses are structured and taught in most colleges and universities nationwide. While a number of institutions have stepped forward and addressed this need by creating and offering interdisciplinary courses at the juncture of mathematics and biology, there are still many others at which there is little, if any, interdisciplinary interaction between the curricula. This chapter describes an interdisciplinary course and a textbook in mathematical biology developed collaboratively by faculty from Sweet Briar College and the University of Virginia School of Medicine. The course and textbook are designed to provide a bridge between the mathematical and biological sciences at the lower undergraduate level. The course is developed for and is being taught in a liberal arts setting at Sweet Briar College, Virginia, but some of the advanced modules are used in a course at the University of Virginia for advanced undergraduate and beginning graduate students. The individual modules are relatively independent and can be used as stand-alone projects in conventional mathematics and biology courses. Except for the introductory material, the course and textbook topics are based on current biomedical research.

Applying the Common Sense Model to Understand Representations of Arsenic Contaminated Well Water

PubMed Central

Severtson, Dolores J.; Baumann, Linda C.; Brown, Roger L.

2015-01-01

Theory-based research is needed to understand how people respond to environmental health risk information. The common sense model of self-regulation and the mental models approach propose that information shapes individual’s personal understandings that influence their decisions and actions. We compare these frameworks and explain how the common sense model (CSM) was applied to describe and measure mental representations of arsenic contaminated well water. Educational information, key informant interviews, and environmental risk literature were used to develop survey items to measure dimensions of cognitive representations (identity, cause, timeline, consequences, control) and emotional representations. Surveys mailed to 1067 private well users with moderate and elevated arsenic levels yielded an 84% response rate (n=897). Exploratory and confirmatory factor analyses of data from the elevated arsenic group identified a factor structure that retained the CSM representational structure and was consistent across moderate and elevated arsenic groups. The CSM has utility for describing and measuring representations of environmental health risks thus supporting its application to environmental health risk communication research. PMID:18726811

Quantitative secondary ion mass spectrometric analysis of secondary ion polarity in GaN films implanted with oxygen

NASA Astrophysics Data System (ADS)

Hashiguchi, Minako; Sakaguchi, Isao; Adachi, Yutaka; Ohashi, Naoki

2016-10-01

Quantitative analyses of N and O ions in GaN thin films implanted with oxygen ions (16O+) were conducted by secondary ion mass spectrometry (SIMS). Positive (CsM+) and negative secondary ions extracted by Cs+ primary ion bombardment were analyzed for oxygen quantitative analysis. The oxygen depth profiles were obtained using two types of primary ion beams: a Gaussian-type beam and a broad spot beam. The oxygen peak concentrations in GaN samples were from 3.2 × 1019 to 7.0 × 1021 atoms/cm3. The depth profiles show equivalent depth resolutions in the two analyses. The intensity of negative oxygen ions was approximately two orders of magnitude higher than that of positive ions. In contrast, the O/N intensity ratio measured using CsM+ molecular ions was close to the calculated atomic density ratio, indicating that the SIMS depth profiling using CsM+ ions is much more effective for the measurements of O and N ions in heavy O-implanted GaN than that using negative ions.

Modeling the binary circumstellar medium of Type IIb/L/n supernova progenitors

NASA Astrophysics Data System (ADS)

Kolb, Christopher; Blondin, John; Borkowski, Kazik; Reynolds, Stephen

2018-01-01

Circumstellar interaction in close binary systems can produce a highly asymmetric environment, particularly for systems with a mass outflow velocity comparable to the binary orbital speed. This asymmetric circumstellar medium (CSM) becomes visible after a supernova explosion, when SN radiation illuminates the gas and when SN ejecta collide with the CSM. We aim to better understand the development of this asymmetric CSM, particularly for binary systems containing a red supergiant progenitor, and to study its impact on supernova morphology. To achieve this, we model the asymmetric wind and subsequent supernova explosion in full 3D hydrodynamics using the shock-capturing hydro code VH-1 on a spherical yin-yang grid. Wind interaction is computed in a frame co-rotating with the binary system, and gas is accelerated using a radiation pressure-driven wind model where optical depth of the radiative force is dependent on azimuthally-averaged gas density. We present characterization of our asymmetric wind density distribution model by fitting a polar-to-equatorial density contrast function to free parameters such as binary separation distance, primary mass loss rate, and binary mass ratio.

Directional borehole radar tests of an oil injection experiment at the Colorado School of Mines, Golden, Colorado

USGS Publications Warehouse

Abraham, Jared D.; Moulton, Craig; Brown, Philip J.

2002-01-01

In October 2001, the U.S. Geological Survey conducted borehole radar surveys of an oil injection experiment at the Colorado School of Mines (CSM), in Golden Colorado using the prototype U.S. Geological Survey (USGS)-developed directional borehole radar system (DBOR). A explanation of the system can be found in Wright and others (2001). The USGS was invited to the CSM to deploy the prototype directional borehole radar system during an oil injection experiment conducted to investigate the applicability of radar to monitoring formation invasion from a horizontal borehole. This work was conducted by a student at the CSM and is summarized in Moita (2001). The purpose of this report is to release the data and to summarize the experiments conducted with the DBOR system. This report contains, (1) a description of the system as deployed in the experiments, (2) a description of the data collected and data parameters used, (3) a simple display of some of the data collected, and (4) a description of the DBOR data files.

Continuum Level Density of a Coupled-Channel System in the Complex Scaling Method

NASA Astrophysics Data System (ADS)

Suzuki, R.; Kruppa, A. T.; Giraud, B. G.; Katō, K.

2008-06-01

We study the continuum level density (CLD) in the formalism of the complex scaling method (CSM) for coupled-channel systems. We apply the formalism to the ^{4}He = [^{3}H + p] + [^3{He} + n] coupled-channel cluster model where there are resonances at low energy. Numerical calculations of the CLD in the CSM with a finite number of L^{2} basis functions are consistent with the exact result calculated from the S-matrix by solving coupled-channel equations. We also study channel densities. In this framework, the extended completeness relation (ECR) plays an important role.

Lunar Module 3 attached to Saturn V third stage

NASA Image and Video Library

1969-03-03

AS09-19-2919 (3 March 1969) --- The Lunar Module (LM) "Spider", still attached to the Saturn V third (S-IVB) stage, is photographed from the Command and Service Modules (CSM) "Gumdrop" on the first day of the Apollo 9 Earth-orbital mission. This picture was taken following CSM/LM-S-IVB separation and prior to LM extraction from the S-IVB. The Spacecraft Lunar Module Adapter (SLA) panels have already been jettisoned. Inside the Command Module were astronauts James A. McDivitt, commander; David R. Scott, command module pilot; and Russell L. Schweickart, lunar module pilot.

Apollo 9 Mission image - Top view of the Lunar Module (LM) spacecraft from the Command Module (CM)

NASA Image and Video Library

1969-03-03

The Lunar Module (LM) 3 "Spider",still attached to the Saturn V third (S-IVB) stage,is photographed from the Command/Service Module (CSM) "Gumdrop" on the first day of the Apollo 9 Earth-orbital mission. This picture was taken following CSM/LM-S-IVB separation,and prior to LM extraction from the S-IVB. The Spacecraft Lunar Module Adapter (SLA) panels have already been jettisoned. Film magazine was A,film type was SO-368 Ektachrome with 0.460 - 0.710 micrometers film / filter transmittance response and haze filter, 80mm lens.

SKYLAB (SL) - ORBITAL WORKSHOP (OWS) - JSC

NASA Image and Video Library

1973-05-29

S73-26849 (25 May 1973) --- Four flight directors for the Skylab 1 and 2 mission are grouped around the flight director's console in the Mission Operations Control Room in the Mission Control Center at Johnson Space Center during the Skylab 2 Command/Service Module (CSM) "fly around" inspection of the Skylab 1 space station cluster. They are, going counterclockwise from center foreground, Donald R. Puddy (white shirt), Milton Windler, Philip C. Shaffer and M.P. Frank. A view of the Skylab 1 Orbital Workshop seen from the Skylab 2 CSM is visible on the television monitor in the background. Photo credit: NASA

Single Degenerate Models for Type Ia Supernovae: Progenitor's Evolution and Nucleosynthesis Yields

NASA Astrophysics Data System (ADS)

Nomoto, Ken'ichi; Leung, Shing-Chi

2018-06-01

We review how the single degenerate models for Type Ia supernovae (SNe Ia) works. In the binary star system of a white dwarf (WD) and its non-degenerate companion star, the WD accretes either hydrogen-rich matter or helium and undergoes hydrogen and helium shell-burning. We summarize how the stability and non-linear behavior of such shell-burning depend on the accretion rate and the WD mass and how the WD blows strong wind. We identify the following evolutionary routes for the accreting WD to trigger a thermonuclear explosion. Typically, the accretion rate is quite high in the early stage and gradually decreases as a result of mass transfer. With decreasing rate, the WD evolves as follows: (1) At a rapid accretion phase, the WD increase its mass by stable H burning and blows a strong wind to keep its moderate radius. The wind is strong enough to strip a part of the companion star's envelope to control the accretion rate and forms circumstellar matter (CSM). If the WD explodes within CSM, it is observed as an "SN Ia-CSM". (X-rays emitted by the WD are absorbed by CSM.) (2) If the WD continues to accrete at a lower rate, the wind stops and an SN Ia is triggered under steady-stable H shell-burning, which is observed as a super-soft X-ray source: "SN Ia-SSXS". (3) If the accretion continues at a still lower rate, H shell-burning becomes unstable and many flashes recur. The WD undergoes recurrent nova (RN) whose mass ejection is smaller than the accreted matter. Then the WD evolves to an "SN Ia-RN". (4) If the companion is a He star (or a He WD), the accretion of He can trigger He and C double detonations at the sub-Chandrasekhar mass or the WD grows to the Chandrasekhar mass while producing a He-wind: "SN Ia-He CSM". (5) If the accreting WD rotates quite rapidly, the WD mass can exceed the Chandrasekhar mass of the spherical WD, which delays the trigger of an SN Ia. After angular momentum is lost from the WD, the (super-Chandra) WD contracts to become a delayed SN Ia. The companion star has become a He WD and CSM has disappeared: "SN Ia-He WD". We update nucleosynthesis yields of the carbon deflagration model W7, delayed detonation model WDD2, and the sub-Chandrasekhar mass model to provide some constraints on the yields (such as Mn) from the comparison with the observations. We note the important metallicity effects on 58Ni and 55Mn.

Computational Thermodynamics of Materials Zi-Kui Liu and Yi Wang

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devanathan, Ram

This authoritative volume introduces the reader to computational thermodynamics and the use of this approach to the design of material properties by tailoring the chemical composition. The text covers applications of this approach, introduces the relevant computational codes, and offers exercises at the end of each chapter. The book has nine chapters and two appendices that provide background material on computer codes. Chapter 1 covers the first and second laws of thermodynamics, introduces the spinodal as the limit of stability, and presents the Gibbs-Duhem equation. Chapter 2 focuses on the Gibbs energy function. Starting with a homogeneous system with amore » single phase, the authors proceed to phases with variable compositions, and polymer blends. The discussion includes the contributions of external electric and magnetic fields to the Gibbs energy. Chapter 3 deals with phase equilibria in heterogeneous systems, the Gibbs phase rule, and phase diagrams. Chapter 4 briefly covers experimental measurements of thermodynamic properties used as input for thermodynamic modeling by Calculation of Phase Diagrams (CALPHAD). Chapter 5 discusses the use of density functional theory to obtain thermochemical data and fill gaps where experimental data is missing. The reader is introduced to the Vienna Ab Initio Simulation Package (VASP) for density functional theory and the YPHON code for phonon calculations. Chapter 6 introduces the modeling of Gibbs energy of phases with the CALPHAD method. Chapter 7 deals with chemical reactions and the Ellingham diagram for metal-oxide systems and presents the calculation of the maximum reaction rate from equilibrium thermodynamics. Chapter 8 is devoted to electrochemical reactions and Pourbaix diagrams with application examples. Chapter 9 concludes this volume with the application of a model of multiple microstates to Ce and Fe3Pt. CALPHAD modeling is briefly discussed in the context of genomics of materials. The book introduces basic thermodynamic concepts clearly and directs readers to appropriate references for advanced concepts and details of software implementation. The list of references is quite comprehensive. The authors make liberal use of diagrams to illustrate key concepts. The two Appendices at the end discuss software requirements and the file structure, and present templates for special quasi-random structures. There is also a link to download pre-compiled binary files of the YPHON code for Linux or Microsoft Windows systems. The exercises at the end of the chapters assume that the reader has access to VASP, which is not freeware. Readers without access to this code can work on a limited number of exercises. However, results from other first principles codes can be organized in the YPHON format as explained in the Appendix. This book will serve as an excellent reference on computational thermodynamics and the exercises provided at the end of each chapter make it valuable as a graduate level textbook. Reviewer: Ram Devanathan is Acting Director of Earth Systems Science Division, Pacific Northwest National Laboratory, USA.« less

Introduction to High-Energy Astrophysics

NASA Astrophysics Data System (ADS)

Rosswog, Stephan; Bruggen, Marcus

2003-04-01

High-energy astrophysics covers cosmic phenomena that occur under the most extreme physical conditions. It explores the most violent events in the Universe: the explosion of stars, matter falling into black holes, and gamma-ray bursts - the most luminous explosions since the Big Bang. Driven by a wealth of new observations, the last decade has seen a large leap forward in our understanding of these phenomena. Exploring modern topics of high-energy astrophysics, such as supernovae, neutron stars, compact binary systems, gamma-ray bursts, and active galactic nuclei, this textbook is ideal for undergraduate students in high-energy astrophysics. It is a self-supporting, timely overview of this exciting field of research. Assuming a familiarity with basic physics, it introduces all other concepts, such as gas dynamics or radiation processes, in an instructive way. An extended appendix gives an overview of some of the most important high-energy astrophysics instruments, and each chapter ends with exercises.• New, up-to-date, introductory textbook providing a broad overview of high-energy phenomena and the many advances in our knowledge gained over the last decade • Written especially for undergraduate teaching use, it introduces the necessary physics and includes many exercises • This book fills a valuable niche at the advanced undergraduate level, providing professors with a new modern introduction to the subject

NASA systems engineering handbook

NASA Astrophysics Data System (ADS)

Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; McDuffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

1995-06-01

This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive.