The Role of Musk in Relieving the Neurodegenerative Changes Induced After Exposure to Chronic Stress.

PubMed

Abd El Wahab, Manal Galal; Ali, Soad Shaker; Ayuob, Nasra Naeim

2018-06-01

This study aimed to evaluate the effect induced by musk on Alzheimer's disease-such as neurodegenerative changes in mice exposed to chronic unpredictable mild stress (CUMS). Forty male Swiss albino mice were divided into 4 groups (n = 10); control, CUMS, CUMS + fluoxetine, CUMS + musk. At the end of the experiment, behavior of the mice was assessed. Serum corticosterone level, hippocampal protein level of the glucocorticoid receptors, and brain-derived neurotropic factor were also assessed. Hippocampus was histopathologically examined. Musk improved depressive status induced after exposure to CUMS as evidenced by the forced swimming and open field tests and improved the short-term memory as evidenced by the elevated plus maze test. Musk reduced both corticosterone levels and the hippocampal neurodegenerative changes observed after exposure to CUMS. These improvements were comparable to those induced by fluoxetine. Musk alleviated the memory impairment and neurodegenerative changes induced after exposure to the chronic stress.

78 FR 67146 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

.... Cummings, III; Nanette Weaver Cummings; George W. Cummings, Jr.; Dewey F. Weaver Jr.; Colby Weaver, all of Monroe, Louisiana; Twist Family, LLP; Randall Twist, both of Dallas, Texas; and Dewey Weaver, III, West...

Rare quantum metastable states in the strongly dispersive Jaynes-Cummings oscillator

NASA Astrophysics Data System (ADS)

Mavrogordatos, Th. K.; Barratt, F.; Asari, U.; Szafulski, P.; Ginossar, E.; Szymańska, M. H.

2018-03-01

We present evidence of metastable rare quantum-fluctuation switching for the driven dissipative Jaynes-Cummings oscillator coupled to a zero-temperature bath in the strongly dispersive regime. We show that single-atom complex amplitude bistability is accompanied by the appearance of a low-amplitude long-lived transient state, hereinafter called the "dark state", having a distribution with quasi-Poissonian statistics both for the coupled qubit and cavity mode. We find that the dark state is linked to a spontaneous flipping of the qubit state, detuning the cavity to a low-photon response. The appearance of the dark state is correlated with the participation of the two metastable states in the dispersive bistability, as evidenced by the solution of the master equation and single quantum trajectories.

Coumarin Derivative Directly Coordinated to Lanthanides Acts as an Excellent Antenna for UV-Vis and Near-IR Emission.

PubMed

Guzmán-Méndez, Óscar; González, Federico; Bernès, Sylvain; Flores-Álamo, Marcos; Ordóñez-Hernández, Javier; García-Ortega, Héctor; Guerrero, Joselin; Qian, Wenjie; Aliaga-Alcalde, Nuria; Gasque, Laura

2018-02-05

A chelating coumarin-derived ligand sensitizes all emitting lanthanide ions in the solid state and gives high absolute quantum yields for ethanol solutions of complexes of Sm, Eu, Tb, and Dy, above 20% for the last two. Crystal structures of these four complexes are [Ln(Cum) 3 (H 2 O)(X)]·X where X = MeOH or EtOH.

[Open-field behavioral study in rat hyperlipidemia combined with chronic unpredictable mild stress model].

PubMed

Hu, Hua; Zhang, Yingchun; Xu, Yeqing; Liu, Chunfeng; Wang, Liwei

2015-06-16

To investigate behavioral changes in a rat hyperlipidemia model induced by high lipid feed combined with depression by Chronic Unpredictable Mild Stress (CUMS). A total of 40 rats were randomly divided into control (CON), control feed for 9 weeks followed by CUMS for 4 weeks (CON + CUMS), high fat diet (HFD) and high lipid feed for 9 weeks followed by CUMS for 4 weeks (HFD + CUMS) (n = 10 each). Open-field test was individually measured at baseline, week 9 and week 13. (1) Serum lipids: total cholesterol [(2.67 ± 0.04) mmol/L, (2.68 ± 0.02) mmol/L] and low density lipoprotein [(1.08 ± 0.03) mmol/L, (1.06 ± 0.01) mmol/L] of HFD and HFD + CUMS were both significantly higher than those of CON and CON + CUMS [(1.78 ± 0.12) mmol/L, (0.79 ± 0.04) mmol/L; (1.76 ± 0.09) mmol/L, (0.76 ± 0.06) mmol/L, all P < 0.01]. (2) Open-field test: at week 13, compared to CON rats, CON + CUMS rats exhibited enhanced locomotor activity during the first minute, reduced activity in the center squares and rearing, and increased the number of grooming and defecation (all P < 0.05). In comparison to the CON rats, a decrease in total squares in 5 min, central squares and peripheral squares was observed in HFD rats at week 13 (all P < 0.05). However, compared with HFD, CON, CON + CUMS rats, when high lipid feed for 9 weeks combined with depression, significant decrease activities in total squares in 5 min, central squares and peripheral squares were observed in HFD + CUMS rats at week 13. Besides these, the number of rearing was reduced, however, locomotor activity during the first minute and the number of grooming and defecation was significantly increased (all P < 0.001). Under uncontrolled hyperlipidemia, severe depressive symptoms will present more early once exposure to a series of chronic stressors followed by significant autonomic nervous dysfunctional symptoms.

Predictive Value of Cumulative Blood Pressure for All-Cause Mortality and Cardiovascular Events

NASA Astrophysics Data System (ADS)

Wang, Yan Xiu; Song, Lu; Xing, Ai Jun; Gao, Ming; Zhao, Hai Yan; Li, Chun Hui; Zhao, Hua Ling; Chen, Shuo Hua; Lu, Cheng Zhi; Wu, Shou Ling

2017-02-01

The predictive value of cumulative blood pressure (BP) on all-cause mortality and cardiovascular and cerebrovascular events (CCE) has hardly been studied. In this prospective cohort study including 52,385 participants from the Kailuan Group who attended three medical examinations and without CCE, the impact of cumulative systolic BP (cumSBP) and cumulative diastolic BP (cumDBP) on all-cause mortality and CCEs was investigated. For the study population, the mean (standard deviation) age was 48.82 (11.77) years of which 40,141 (76.6%) were male. The follow-up for all-cause mortality and CCEs was 3.96 (0.48) and 2.98 (0.41) years, respectively. Multivariate Cox proportional hazards regression analysis showed that for every 10 mm Hg·year increase in cumSBP and 5 mm Hg·year increase in cumDBP, the hazard ratio for all-cause mortality were 1.013 (1.006, 1.021) and 1.012 (1.006, 1.018); for CCEs, 1.018 (1.010, 1.027) and 1.017 (1.010, 1.024); for stroke, 1.021 (1.011, 1.031) and 1.018 (1.010, 1.026); and for MI, 1.013 (0.996, 1.030) and 1.015 (1.000, 1.029). Using natural spline function analysis, cumSBP and cumDBP showed a J-curve relationship with CCEs; and a U-curve relationship with stroke (ischemic stroke and hemorrhagic stroke). Therefore, increases in cumSBP and cumDBP were predictive for all-cause mortality, CCEs, and stroke.

The antidepressant-like effect of Ocimum basilicum in an animal model of depression.

PubMed

Ali, S S; Abd El Wahab, M G; Ayuob, N N; Suliaman, M

2017-01-01

We investigated the efficacy of Ocimum basilicum (OB) essential oils for treating depression related behavioral, biochemical and histopathological changes caused by exposure to chronic unpredictable mild stress (CUMS) in mice and to explore the mechanism underlying the pathology. Male albino mice were divided into four groups: controls; CUMS; CUMS plus fluoxetine, the antidepressant administered for pharmacological validation of OB; and CUMS plus OB. Behavioral tests included the forced swim test (FST), elevated plus-maze (EPM) and the open field test (OFT); these tests were performed at the end of the experiment. We assessed serum corticosterone level, protein, gene and immunoexpression of brain-derived neurotropic factor (BDNF) and glucocorticoid receptors (GRs) as well as immunoexpression of glial fibrillary acidic protein (GFAP), Ki67, caspase-3 in the hippocampus. CUMS caused depression in the mice as evidenced by prolonged immobility in the FST, prolonged time spent in the open arms during the EPM test and reduction of open field activity in the OFT. OB ameliorated the CUMS induced depressive status. OB significantly reduced the corticosterone level and up-regulated protein and gene expressions of BDNF and GR. OB reduced CUMS induced hippocampal neuron atrophy and apoptosis, and increased the number of the astrocytes and new nerve cells. OB significantly increased GFAP-positive cells as well as BDNF and GR immunoexpression in the hippocampus.

microRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience.

PubMed

Sun, Xiaoyan; Song, Zhenhua; Si, Yawei; Wang, Jin-Hui

2018-06-01

Chronic stress with lack of reward presumably may impair brain reward circuit, leading to major depressive disorder (MDD). Most individuals experiencing chronic stress do not suffer from MDD, i.e., resilience, implying the presence of endogenous anti-depression in the brain. Molecular mechanisms underlying stress-induced depression versus resilience were investigated. Mice were treated by chronic unpredictable mild stress (CUMS) for four weeks. Their mood state was assessed by behavioral tasks, such as sucrose preference, Y-maze and forced swimming testes. To reveal comprehensive molecular profiles of major depression versus resilience, mRNA and microRNA profiles were analyzed by high-throughput sequencing in the ventral tegmental area (VTA) harvested from control, CUMS-susceptible and CUMS-resilience mice. In data analyses of control versus CUMS-susceptible mice as well as control versus CUMS-resilience mice, 1.5 fold ratio in reads per kilo-base per million reads was set as the threshold to judge the involvement of mRNAs and microRNAs in the CUMS, depression or resilience. The downregulation of synaptic vesicle cycle, neurotrophin, GABAergic synapse and morphine addiction as well as the upregulation of transmitter release, calcium signal and cAMP-dependent response element binding are associated to CUMS-susceptibility. The downregulation of tyrosine metabolism and protein process in endoplasmic reticulum as well as the upregulation of amino acid biosynthesis, neuroactive ligand-receptor interaction and dopaminergic synapse are associated to CUMS-resilience. Therefore, the impairment of neurons and GABA/dopaminergic synapses in the VTA is associated with major depression. The upregulation of these entities is associated with resilience. Consistent results obtained from analyzing mRNAs and microRNAs as well as using different approaches strengthen our finding and conclusion. Copyright © 2018. Published by Elsevier Inc.

Modified n-level, n - 1-mode Tavis-Cummings model and algebraic Bethe ansatz

NASA Astrophysics Data System (ADS)

Skrypnyk, T.

2018-01-01

Using the quantum group technique we construct a one-parametric family of integrable modifications of the n-level, n-1 mode Tavis-Cummings Hamiltonian possessing an additional Stark-type term. We show that in the ‘quasiclassical’ limit the constructed Hamiltonian transforms into the integrable Hamiltonian of the quantum n-level, n-1 mode Tavis-Cummings model with the equal interaction strengths considered in Skrypnyk (2008 J. Phys. A: Math. Theor. 41 475202, 2009 J. Math. Phys. 50 103523). We diagonalize the constructed ‘modified’ Tavis-Cummings Hamiltonian and its second order integrals of motion using the nested Bethe ansatz.

Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin.

PubMed

Filho, C B; Jesse, C R; Donato, F; Giacomeli, R; Del Fabbro, L; da Silva Antunes, M; de Gomes, M G; Goes, A T R; Boeira, S P; Prigol, M; Souza, L C

2015-03-19

Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide satisfactory effects on antidepressant therapy. Thus, we aimed to evaluate the effect of CUMS on brain-derived neurotropic factor (BDNF) and nerve growth factor (NGF) levels as well as the Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of female mice. We also aimed to examine the effect of a 28-day oral treatment with chrysin (5 or 20mg/kg) in female mice subjected to CUMS, comparing to the effect of fluoxetine. Results showed that CUMS applied for 28days induced a decrease in BDNF and NGF levels as well as in the Na(+),K(+)-ATPase activity. CUMS also promoted a depressive status in the swimming forced test (FST), in the sucrose preference test, and in corticosterone levels. Chrysin (20mg/kg) and fluoxetine also occasioned the up-regulation of BDNF and NGF levels in non-stressed mice and in mice subjected to CUMS. CUMS decreased non-protein thiol (NPSH) levels and increased reactive oxygen species (ROS) levels. In response to these changes, the glutathione reductase (GR), glutathione peroxidase (GPx) and catalase (CAT) activities were increased in mice exposed to CUMS. Chrysin and fluoxetine treatments protected against all these alterations, suggesting the involvement of the antioxidant function in the antidepressant effect of chrysin and fluoxetine. In conclusion, CUMS decreased BDNF and NGF levels as well as the Na(+),K(+)-ATPase activity in mice. Chrysin presented antidepressant effect in mice on behavioral, neurotrophic and biochemistry parameters equivalent to fluoxetine. Furthermore, we suggest that the up-regulation of BDNF and NGF levels is a mechanism possibly involved in the antidepressant effect of chrysin in mice. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic unpredictable mild stress model by involving monoamines and BDNF.

PubMed

Wang, Jun-Ming; Pei, Li-Xin; Zhang, Yue-Yue; Cheng, Yong-Xian; Niu, Chun-Ling; Cui, Ying; Feng, Wei-Sheng; Wang, Gui-Fang

2018-06-01

The dried roots of Rehmannia glutinosa Libosch. (Scrophulariaceae) are of both medicinal and nutritional importance. Our previous study has found that the 80% ethanol extract of R. glutinosa (RGEE) produced antidepressant-like activities in mouse behavioral despair depression models. However, its mechanisms are still unclear. The present study aimed to observe the antidepressant-like mechanisms of RGEE on a rat chronic unpredictable mild stress (CUMS) model by involving monoaminergic neurotransmitters and brain-derived neurotrophic factor (BDNF). CUMS-stressed rats were orally given RGEE daily (150, 300, and 600 mg/kg) or fluoxetine hydrochloride (FH) for 3 weeks after starting the CUMS procedure. Sucrose preference test was carried out to observe depression-like behavior, and serum and brain tissues were used for neurochemical and fluorescent quantitative reverse transcription PCR analysis. Results demonstrated that CUMS induced depression-like behavior, whereas RGEE and FH administration inhibited this symptom. Furthermore, CUMS caused excessively elevated levels of serum corticosterone (CORT), an index of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, in a manner attenuated by RGEE and FH administration. RGEE administration also further elevated monoamine neurotransmitters and BDNF levels, up-regulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB) in hippocampus of rats suffering CUMS. Together, our findings suggest that RGEE can improve CUMS-evoked depression-like behavior, and indicate its mechanisms may partially be associated with restoring HPA axis dysfunctions, enhancing monoamineergic nervous systems, and up-regulating BDNF and TrkB expression.

BDNF/TrkB Pathway Mediates the Antidepressant-Like Role of H2S in CUMS-Exposed Rats by Inhibition of Hippocampal ER Stress.

PubMed

Wei, Le; Kan, Li-Yuan; Zeng, Hai-Ying; Tang, Yi-Yun; Huang, Hong-Lin; Xie, Ming; Zou, Wei; Wang, Chun-Yan; Zhang, Ping; Tang, Xiao-Qing

2018-06-01

Our previous works have shown that hydrogen sulfide (H 2 S) significantly attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and hippocampal endoplasmic reticulum (ER) stress. Brain-derived neurotrophic factor (BDNF) generates an antidepressant-like effect by its receptor tyrosine protein kinase B (TrkB). We have previously found that H 2 S upregulates the expressions of BDNF and p-TrkB in the hippocampus of CUMS-exposed rats. Therefore, the present work was to explore whether BDNF/TrkB pathway mediates the antidepressant-like role of H 2 S by blocking hippocampal ER stress. We found that treatment with K252a (an inhibitor of BDNF/TrkB pathway) significantly increased the immobility time in the forced swim test and tail suspension test and increased the latency to feed in the novelty-suppressed feeding test in the rats cotreated with sodium hydrosulfide (NaHS, a donor of H 2 S) and CUMS. Similarly, K252a reversed the protective effect of NaHS against CUMS-induced hippocampal ER stress, as evidenced by increases in the levels of ER stress-related proteins, glucose-regulated protein 78, CCAAT/enhancer binding protein homologous protein and cleaved caspase-12. Taken together, our results suggest that BDNF/TrkB pathway plays an important mediatory role in the antidepressant-like action of H 2 S in CUMS-exposed rats, which is by suppression of hippocampal ER stress. These data provide a novel mechanism underlying the protection of H 2 S against CUMS-induced depressive-like behaviors.

Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway.

PubMed

Zu, Xianpeng; Zhang, Mingjian; Li, Wencai; Xie, Haisheng; Lin, Zhang; Yang, Niao; Liu, Xinru; Zhang, Weidong

2017-11-01

Preliminary studies conducted in our laboratory have confirmed that Bacopaside I (BS-I), a saponin compound isolated from Bacopa monnieri, displayed antidepressant-like activity in the mouse behavioral despair model. The present investigation aimed to verify the antidepressant-like action of BS-I using a mouse model of behavioral deficits induced by chronic unpredictable mild stress (CUMS) and further probe its underlying mechanism of action. Mice were exposed to CUMS for a period of 5 consecutive weeks to induce depression-like behavior. Then, oral gavage administrations with vehicle (model group), fluoxetine (12 mg/kg, positive group) or BS-I (5, 15, 45 mg/kg, treated group) once daily were started during the last two weeks of CUMS procedure. The results showed that BS-I significantly ameliorated CUMS-induced depression-like behaviors in mice, as characterized by an elevated sucrose consumption in the sucrose preference test and reduced immobility time without affecting spontaneous locomotor activity in the forced swimming test, tail suspension test and open field test. It was also found that BS-I treatment reversed the increased level of plasma corticosterone and decreased mRNA and protein expressions of glucocorticoid receptor induced by CUMS exposure, indicating that hypothalamic-pituitary-adrenal (HPA) axis hyperactivity of CUMS-exposed mice was restored by BS-I treatment. Furthermore, chronic administration of BS-I elevated expression levels of brain-derived neurotrophic factor (BDNF) (mRNA and protein) and activated the phosphorylation of extracellular signal-regulated kinase and cAMP response element-binding protein in the hippocampus and prefrontal cortex in mice subjected to CUMS procedure. Taken together, these results indicated that BS-I exhibited an obvious antidepressant-like effect in mouse model of CUMS-induced depression that was mediated, at least in part, by modulating HPA hyperactivity and activating BDNF signaling pathway.

Graduate Student Support for Quantum Computing With Superconducting Charge States

DTIC Science & Technology

2005-08-31

cavity resonance frequency ωr, the atomic transition frequency Ω, and the strength of the atom- photon coupling g appearing in the Jaynes - Cummings ...the atom through the cavity. In the absence of damping, exact diagonalization of the Jaynes - Cumming Hamiltonian yields the excited eigen- states...cillating terms and omitting damping for the moment, 5 Eq. (16) reduces to the Jaynes - Cummings Hamiltonian (1) with Ω = EJ/~ and the vacuum Rabi frequency

Weekly 24-hour continuous infusion interleukin-2 for metastatic melanoma and renal cell carcinoma: a phase I study.

PubMed

Perez, E A; Scudder, S A; Meyers, F A; Tanaka, M S; Paradise, C; Gandara, D R

1991-02-01

Twenty-nine patients with biopsy-confirmed metastatic melanoma (17) or metastatic renal cell carcinoma (12) were treated with escalating doses or recombinant human interleukin-2 (IL-2) administered as weekly 24-h intravenous infusions. Patients received from 3 to 12 x 10(6) C.U./m2 (18-72 x 10(6) I.U./m2) weekly over a treatment period of 1 to 16 weeks, with a median of eight weekly cycles administered. Patients in all treatment groups experienced non-life-threatening systemic side effects consisting of fever, nausea, vomiting, fluid retention, and diarrhea. Grade III hypotension was seen in four of six patients (67%) at 12 x 10(6) C.U./m2, and represented the dose-limiting toxicity. Grade IV hypotension occurred in 1 of 14 patients at 6 x 10(6) C.U./m2; no other grade IV toxicities were observed. Grade III fever occurred in 3 of 11 patients (27%) treated at 3 x 10(6) C.U./m2, 3 of 14 patients (21%) at 6 x 10(6) C.U./m2, and 3 of 6 patients (50%) at 9 x 10(6) C.U./m2. An objective response was observed in 3 of 28 evaluable patients (10%): 1 complete response and 1 partial response in renal cell cancer, and 1 partial response in a melanoma patient. We conclude that for future studies, the recommended dose of IL-2 given as a weekly 24-h infusion is 9 x 10(6) C.U./m2 and that a low rate of objective tumor response can be obtained in patients with melanoma and renal cell carcinoma using this regimen.

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress.

PubMed

Wang, Jun-Ming; Yang, Lian-He; Zhang, Yue-Yue; Niu, Chun-Ling; Cui, Ying; Feng, Wei-Sheng; Wang, Gui-Fang

2015-11-01

Catalpol, a major compound in Rehmannia glutinosa with both medicinal and nutritional values, has been previously confirmed to shorten the duration of immobility in mice exposed to tail suspension and forced swimming tests. This study attempted to examine the anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress (CUMS) by involving brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (COX-2). CUMS-exposed rats were given catalpol daily (5, 10, and 20mg/kg, ig) or a reference drug, fluoxetine hydrochloride (FH, 10mg/kg, ig), at 5 weeks after starting the CUMS procedure. Sucrose preference test was performed to observe depression-like behavior, and serum and brain tissues were used for neurochemical and fluorescent quantitative reverse transcription PCR analysis. CUMS induced depression-like behavior, whereas catalpol and FH administration attenuated this symptom. Moreover, CUMS caused excessively elevated levels of serum corticosterone, an index of hypothalamic-pituitary-adrenal (HPA) axis hyperactivation, in a manner attenuated by catalpol and FH administration. Catalpol administration also further decreased BDNF activities, downregulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB), and reversed the excessive elevation in the activities and mRNA expression levels of COX-2 and prostaglandin E2 (PGE2) in the hippocampus and frontal cortex of rats undergoing CUMS. Results indicate that catalpol can ameliorate CUMS-induced depression-like behavior, and suggest its mechanisms may partially be ascribed to restoring HPA axis dysfunctions, upregulating BDNF expression and its cognate receptor TrkB, and downregulating COX-2 expression, thereby reducing PGE2 levels in the brain. Copyright © 2015 Elsevier Inc. All rights reserved.

Sex differences in the stress response in SD rats.

PubMed

Lu, Jing; Wu, Xue-Yan; Zhu, Qiong-Bin; Li, Jia; Shi, Li-Gen; Wu, Juan-Li; Zhang, Qi-Jun; Huang, Man-Li; Bao, Ai-Min

2015-05-01

Sex differences play an important role in depression, the basis of which is an excessive stress response. We aimed at revealing the neurobiological sex differences in the same study in acute- and chronically-stressed rats. Female Sprague-Dawley (SD) rats were randomly divided into 6 groups: chronic unpredictable mild stress (CUMS), acute foot shock (FS) and controls, animals in all 3 groups were sacrificed in proestrus or diestrus. Male SD rats were randomly divided into 3 groups: CUMS, FS and controls. Comparisons were made of behavioral changes in CUMS and control rats, plasma levels of corticosterone (CORT), testosterone (T) and estradiol (E2), and of the hypothalamic mRNA-expression of stress-related molecules, i.e. estrogen receptor α and β, androgen receptor, aromatase, mineralocorticoid receptor, glucocorticoid receptor, corticotropin-releasing hormone, arginine vasopressin and oxytocin. CUMS resulted in disordered estrus cycles, more behavioral and hypothalamic stress-related molecules changes and a stronger CORT response in female rats compared with male rats. Female rats also showed decreased E2 and T levels after FS and CUMS, while male FS rats showed increased E2 and male CUMS rats showed decreased T levels. Stress affects the behavioral, endocrine and the molecular response of the stress systems in the hypothalamus of SD rats in a clear sexual dimorphic way, which has parallels in human data on stress and depression. Copyright © 2015 Elsevier B.V. All rights reserved.

Biological effects of short, high-level exposure to gases: ammonia. Phase report, May 1979-May 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Legters, L.J.

1980-05-01

This report presents an analysis and synthesis of the available literature concerned with possible health and performance effects of exposures to ammonia. The US Army's concern is with short, high-level exposures that may exceed present threshold limit values of the American Conference of Governmental Industrial Hygienists (25 ppm or 17 mg/cum as a TWA and a ceiling of 35 ppm or 24 mg/cum for 15 minutes). The organs primarily affected by exposure to ammonia gas are the respiratory tract and the eyes. During brief exposures to concentrations of 500 ppm (348 mg/cum) or less, the biologic responses are immediate, reversible,more » and mainly irritant. Below 50 ppm (35 mg/cum), there are no significant effects except that the odor of ammonia is detectable. Between 50-100 ppm (35-70 mg/cum), most people experience some degree of irritation of the eyes, nose and throat. There is some evidence indicating that personnel may become acclimated to the irritant effects after only 1 or 2 weeks of inhalation.« less

Integrability and superintegrability of the generalized n-level many-mode Jaynes-Cummings and Dicke models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skrypnyk, T.

2009-10-15

We analyze symmetries of the integrable generalizations of Jaynes-Cummings and Dicke models associated with simple Lie algebras g and their reductive subalgebras g{sub K}[T. Skrypnyk, 'Generalized n-level Jaynes-Cummings and Dicke models, classical rational r-matrices and nested Bethe ansatz', J. Phys. A: Math. Theor. 41, 475202 (2008)]. We show that their symmetry algebras contain commutative subalgebras isomorphic to the Cartan subalgebras of g, which can be added to the commutative algebras of quantum integrals generated with the help of the quantum Lax operators. We diagonalize additional commuting integrals and constructed with their help the most general integrable quantum Hamiltonian of themore » generalized n-level many-mode Jaynes-Cummings and Dicke-type models using nested algebraic Bethe ansatz.« less

Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus.

PubMed

Wu, Yun Tao; Song, Lu; Liu, Xiao Xue; Gao, Jing Sheng; Zheng, Xiao Ming; Ruan, Chun Yu; Zhao, Hai Yan; Chen, Shuo Hua; Gao, Wen Yuan; Jonas, Jost B; Wu, Shou Ling

2017-05-02

With the marked increase in the prevalence of diabetes mellitus, it was the purpose of our study to assess a potential association of time-cumulated exposure to systolic (CumSBP) and of diastolic blood pressure (CumDBP) with onset of impaired glucose tolerance and diabetes mellitus. The prospective investigation included participants of the longitudinal Kailuan Study with three baseline examinations in 2006-2007, 2008-2009 and 2010-2011, re-examination in 2012-2013, and no diabetes mellitus at baseline. Cumulative blood pressure (BP) was calculated as cumBP = [(BP 1  + BP 2 )/2 × time 1-2 ] + [(BP 2  + BP 3 )/2 × time 2-3 ]. Based on cumSBP, the study population was stratified into four groups (cumSBP < 480mmHgxyear;n = 15,339; 480mmHgxyear ≤ cumSBP < 520mmHgxyear;n = 7214; 520mmHgxyears ≤ cumSBP < 560mmHgxyears;n = 5675; and cumSBP ≥ 560mmHgxyears;n = 10,576). After adjusting for demographic, anthropomorphic, biochemical, socioeconomic and lifestyle parameters and as compared with the first group, the second, third and fourth group showed a significantly higher incidence of diabetes (P-trend < 0.001;hazard ratio (HR);95% confidence interval (CI):1.28(1.08,1.51),1.54(1.29,1.84), and 2.33(1.98,2.73), respectively), higher incidence of impairment of glucose tolerance (P-trend < 0.001;HR;95% CI1.17(1.02,1.33), 1.43(1.25,1.64), and 2.09(1.85,2.37), respectively), and higher incidence of diabetes developing out of an impairment of glucose tolerance (P-trend < 0.001;HR;95% CI:1.22(0.97,1.54),1.47(1.16,1.86), and 2.01(1.62,2.50), respectively). An increase in cumSBP by 10 mmHg/year or an increase in cumDBP by 5 mmHg/year was associated with a hazard ratio of incident diabetes of 1.04 (95% CI:1.03,1.04) and 1.02(1.02,1.03), respectively, with a hazard ratio of incident impairment of glucose tolerance of 1.04(95% CI:1.03,1.04) and 1.03(95% CI:1.02,1.03), respectively, and with a hazard ratio of incident diabetes developing from impairment of glucose tolerance of 1.04(95% CI:1.03,1.04) and 1.03(95% CI:1.02,1.03), respectively. Time-cumulated exposure to elevated blood pressure was significantly associated with an elevated incidence of impaired glucose tolerance and diabetes.

Cummings/Ju - Harvard; Emory | Division of Cancer Prevention

Cancer.gov

Principal Investigator: Richard D Cummings, PhDInstitution: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA Principal Investigator: Tongzhong Ju, MD, PhDInstitution: Emory University, Atlanta, GA |

Quantum Theory of an Atom Near Partially Reflecting Walls

DTIC Science & Technology

1987-06-15

rotating - wave approximations . Jaynes and Cummings5 but they are damped by the factor e -Y, where y is the , showed that the same sort of "Rabi...equation describing renewed interest in the Jaynes - Cummings model by the coupling of the atoms of the (dielectric) mirror to the describing certain... Jaynes - Cummings model in which one begins a priori way. DISTR1UTION ffATDi0I A 35 5081 @1987 The American Physical Society Approvd for pubWi MIM D19bi

Review of Quantum Electromagnetic States

DTIC Science & Technology

1999-10-01

product space. 227 The wave functions used in the Jaynes - Cummings ’ model reside in a direct product space Va ɠ> Vf where Va and Vf are the Hubert...Dependent Probability 215 5.1.3 The Relaxation Term 217 5.2 Jaynes - Cummings ’ Model for Matter-Field Interactions 218 5.2.1 The Atomic Hamiltonian 218...5.3 The Interaction Representation for the Jaynes - Cummings ’ Model 224 5.3.1 Atomic Creation and Annihilation Operators 224 5.3.2 The Boson Creation

Hypersomnia

MedlinePlus

... 5885 Cumming Highway Suite 108-255 Sugar Hill GA Sugar Hill, GA 30518 http://www.hypersomniafoundation.org Tel: 844-342- ... 5885 Cumming Highway Suite 108-255 Sugar Hill GA Sugar Hill, GA 30518 http://www.hypersomniafoundation.org ...

WRR editor Ronald Cummings

NASA Astrophysics Data System (ADS)

1984-04-01

It has been nearly a year since Ronald Cummings took over as policy sciences editor of Water Resources Research (WRR), and in that time he has worked to make the journal live up to its role as “an interdisciplinary journal integrating research in the social and natural sciences of water.” Cummings takes the “interdisciplinary” part seriously. “I'd like to see a much broader range of policy issues presented to readers,” he says. “I would hope it would then stimulate interchange between our colleagues concerning evolving issues of the '80s and '90s.”Cummings brings a solid background as a resource economist to his 4-year term as editor, which began last January and runs until December 1987. Cummings succeeds Jared Cohon as policy sciences editor. Stephen J. Burges is the WRR editor for hydrological, physical, chemical, and biological sciences. Now a Professor of Economics and Director of the Program in Natural Resources Economics at the University of New Mexico, Cummings is a past president of the Association of Environmental and Resource Economists. He has been a consultant in matters of water resources management, forestry management, and energy policy for more than a decade, working on projects in both the United States and Latin America. Since joining the faculty at New Mexico in 1975, he has, among other things, worked with engineers at the Los Alamos National Laboratory in developing operation'management models for hot, dry rock geothermal systems.

'Mr Cummings clearly does not understand the science of genetics and should maybe go back to school on the subject': an exploratory content analysis of the online comments beneath a controversial news story.

PubMed

Crosswaite, Madeline; Asbury, Kathryn

2016-12-01

An article published in the UK Guardian on 11/10/2013 with the headline 'Genetics outweighs teaching, Gove advisor tells his boss' reported a leaked document written by special advisor Dominic Cummings to the then UK Secretary of State for Education, Michael Gove. The article generated 3008 on-line reader comments from the public. These reader comments offer a naturalistic opportunity to understand public opinion regarding Cummings' controversial suggestions and ideas. We conducted a content analysis of n = 800 reader comments, coding them on the basis of level of agreement with the ideas and opinions expressed in the article. Of all aspects of education mentioned, Cummings' reported views on genetics were commented upon most frequently and were subject to the most opposition from commenters, but also the most support. Findings offer some insight into the challenges involved in conducting public discourse about the relevance of genes in education. We discuss the accuracy with which Cummings' views were presented and the effect this may have had on reader responses to the points being raised.

Hearing loss and music

MedlinePlus

... BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: ... BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: ...

Fusion of the ear bones

MedlinePlus

... BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: ... BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: ...

Optical Spectra of the Jaynes-Cummings Ladder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laussy, Fabrice P.; Valle, Elena del

2009-06-29

We explore how the Jaynes-Cummings ladder transpires in the emitted spectra of a two-level system in strong coupling with a single mode of light. We focus on the case of very strong coupling, that would be achieved with systems of exceedingly good quality (very long lifetimes for both the emitter and the cavity). We focus on the incoherent regime of excitation, that is realized with semiconductors quantum dots in microcavities, and discuss how reasonable is the understanding of the systems in terms of transitions between dressed states of the Jaynes-Cummings Hamiltonian.

Oscillator-like coherent states for the Jaynes-Cummings Model

NASA Technical Reports Server (NTRS)

Berubelauziere, Y.; Hussin, V.; Nieto, Michael M.

1995-01-01

A new way of diagonalizing the Jaynes-Cummings Hamiltonian is proposed, which allows the definition of annihilation operators and coherent states for this model. Mean values and dispersions over these states are computed and interpreted.

Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor.

PubMed

Li, Meng; Fu, Qiang; Li, Ying; Li, Shanshan; Xue, Jinsong; Ma, Shiping

2014-10-01

Emodin, the major active component of Rhubarb, has shown neuroprotective activity. This study is attempted to investigate whether emodin possesses beneficial effects on chronic unpredictable mild stress (CUMS)-induced behavioral deficits (depression-like behaviors) and explore the possible mechanisms. ICR mice were subjected to chronic unpredictable mild stress for 42 consecutive days. Then, emodin and fluoxetine (positive control drug) were administered for 21 consecutive days at the last three weeks of CUMS procedure. The classical behavioral tests: open field test (OFT), sucrose preference test (SPT), tail suspension test (TST) and forced swimming test (FST) were applied to evaluate the antidepressant effects of emodin. Then plasma corticosterone concentration, hippocampal glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) levels were tested to probe the mechanisms. Our results indicated that 6 weeks of CUMS exposure induced significant depression-like behavior, with high, plasma corticosterone concentration and low hippocampal GR and BDNF expression levels. Whereas, chronic emodin (20, 40 and 80 mg/kg) treatments reversed the behavioral deficiency induced by CUMS exposure. Treatment with emodin normalized the change of plasma corticosterone level, which demonstrated that emodin could partially restore CUMS-induced HPA axis impairments. Besides, hippocampal GR (mRNA and protein) and BDNF (mRNA) expressions were also up-regulated after emodin treatments. In conclusion, emodin remarkably improved depression-like behavior in CUMS mice and its antidepressant activity is mediated, at least in part, by the up-regulating GR and BDNF levels in hippocampus. Copyright © 2014 Elsevier B.V. All rights reserved.

Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?

PubMed

Ayuob, Nasra Naeim; Firgany, Alaa El-Din L; El-Mansy, Ahmed A; Ali, Soad

2017-10-01

Depression is one of the important world-wide health problems. This study aimed to assess the ameliorative effect of Ocimum basilicum (OB) essential oil on the behavioral, biochemical and histopathological changes resulted from exposure to chronic unpredictable mild stress (CUMS). It also aimed to investigate the underlying mechanism in an animal model of depression. Forty male Swiss albino mice were divided into four groups (n=10): control, CUMS (exposed to CUMS for 4weeks), CUMS plus fluoxetine, and CUMS plus OB. At the end of the experiment, behavioral changes, serum corticosterone level, protein and gene expressions of brain derived neurotropic factor (BDNF) and glucocorticoid receptors (GR) in the hippocampus was all assessed. Immunoexpression of surface makers of glial fibrillary acidic protein (GFAP), Ki67, Caspase-3, BDNF and GR in the hippocampus were estimated. Data were analyzed by using the statistical package for the social sciences (SPSS). OB alleviated both behavioral and biochemical changes recorded in mice after exposure to CUMS. It also reduced neuronal atrophy observed in the hippocampal region III cornu ammonis (CA3) and dentate gyrus and restored back astrocyte number. OB decreased apoptosis in both neurons and glial cells and increased neurogenesis in the dentate gyrus in a pattern comparable to that of fluoxetine. Increased BDNF and GR gene and protein expressions seems to be behind the antidepressant-like effect of OB. Ocimum basilicum ameliorates the changes induced after exposure to the chronic stress. Assessing Ocimum basilicum efficacy on human as antidepressant is recommended in further studies. Copyright © 2017. Published by Elsevier Inc.

Generalized Jaynes-Cummings model as a quantum search algorithm

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanelli, A.

2009-07-15

We propose a continuous time quantum search algorithm using a generalization of the Jaynes-Cummings model. In this model the states of the atom are the elements among which the algorithm realizes the search, exciting resonances between the initial and the searched states. This algorithm behaves like Grover's algorithm; the optimal search time is proportional to the square root of the size of the search set and the probability to find the searched state oscillates periodically in time. In this frame, it is possible to reinterpret the usual Jaynes-Cummings model as a trivial case of the quantum search algorithm.

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model.

PubMed

Deng, Xue-Yang; Xue, Jin-Song; Li, Hong-Yan; Ma, Zhan-Qiang; Fu, Qiang; Qu, Rong; Ma, Shi-Ping

2015-12-01

Geraniol (GE), which has neuroprotection and anti-inflammation activities, is mostly abundant in the essential oils of rose, ginger, lemon, orange, lavender etc. However, its antidepressant-like effect has not been reported before. The present study was designed to investigate whether GE confers an antidepressant effect in mice exposed to a chronic unpredictable mild stress (CUMS) model of depression and to explore its possible mechanisms. The results showed that GE treatments for 3 weeks significantly alleviated the depression-related behaviors of CUMS-exposed mice, as indicated by restored decreased sucrose preference and shortened immobile time in both the forced swimming tests (FST) and tail suspension tests (TST). And these ameliorative effects of GE treatment were involved with regulating CUMS-induced pro-inflammatory cytokine interleukin-1 beta (IL-1β) related neuro-inflammation. We further found that GE treatment reversed CUMS-induced IL-1β elevation, possibly by inhibiting nuclear factor kappa B (NF-κB) pathway activation and regulating nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome expression. Taken together, our findings suggested that GE exerted a potential antidepressant-like effect in CUMS mice model of depression, which may provide an insight into the potential of GE in therapeutic implications for depression. Copyright © 2015 Elsevier Inc. All rights reserved.

Nonequilibrium Quantum Simulation in Circuit QED

NASA Astrophysics Data System (ADS)

Raftery, James John

Superconducting circuits have become a leading architecture for quantum computing and quantum simulation. In particular, the circuit QED framework leverages high coherence qubits and microwave resonators to construct systems realizing quantum optics models with exquisite precision. For example, the Jaynes-Cummings model has been the focus of significant theoretical interest as a means of generating photon-photon interactions. Lattices of such strongly correlated photons are an exciting new test bed for exploring non-equilibrium condensed matter physics such as dissipative phase transitions of light. This thesis covers a series of experiments which establish circuit QED as a powerful tool for exploring condensed matter physics with photons. The first experiment explores the use of ultra high speed arbitrary waveform generators for the direct digital synthesis of complex microwave waveforms. This new technique dramatically simplifies the classical control chain for quantum experiments and enables high bandwidth driving schemes expected to be essential for generating interesting steady-states and dynamical behavior. The last two experiments explore the rich physics of interacting photons, with an emphasis on small systems where a high degree of control is possible. The first experiment realizes a two-site system called the Jaynes-Cummings dimer, which undergoes a self-trapping transition where the strong photon-photon interactions block photon hopping between sites. The observation of this dynamical phase transition and the related dissipation-induced transition are key results of this thesis. The final experiment augments the Jaynes-Cummings dimer by redesigning the circuit to include in-situ control over photon hopping between sites using a tunable coupler. This enables the study of the dimer's localization transition in the steady-state regime.

Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro.

PubMed

Shen, Jun; Xu, Linling; Qu, Chujie; Sun, Huimin; Zhang, Junjian

2018-04-30

Chronic unpredictable mild stress (CUMS) leads to neuropsychiatric disorders, such as depression, anxiety and cognitive impairment. Resveratrol is a natural polyphenol existed in polygonum cuspidatum and has been demonstrated to be a potent activator of Sirtuin 1 (Sirt1). Previous studies reported that resveratrol treatment ameliorated CUMS-induced depressive-like behavior and cognitive deficits through upregulating cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) expression. However, the upstream signalling pathway mediating CREB/BDNF expression and then exerting a protective role on cognitive function remains unclear. The present study aims to investigate the possible mechanism of resveratrol on CUMS-induced cognitive deficits. Male Sprague Dawley rats were adminstrated resveratrol (40 and 80 mg/kg) every day for 4 consecutive weeks before exposure to CUMS procedure. Morris Water Maze test was used to appraise spatial learing and memory of rats. Sirt1/miR-134 signalling pathway and CREB/BDNF expression in hippocampus of rats were measured. We also explored Sirt1/miR-134 signalling pathway and CREB/BDNF expression in primary cultured hippocampus neurons with resveratrol (25, 50 and 100 μmol/L) treatment. We found that resveratrol treatment prevented spatial learing and memory impairment induced by CUMS. Meanwhile the potential mechanism of resveratrol was associated with increased levels of Sirt1, CREB phosphorylation (p-CREB), CREB, BDNF and decreased levels of miR-134 in vivo and in vitro. In conclusion, our study showed that the neuroprotective effect of resveratrol on CUMS-induced cognitive impairment may rely on activating Sirt1/miR-134 pathway and then upregulating its downstream CREB/BDNF expression in hippocampus. Copyright © 2018 Elsevier B.V. All rights reserved.

Alpha particle induced reactions on natCr up to 39 MeV: Experimental cross-sections, comparison with theoretical calculations and thick target yields for medically relevant 52gFe production

NASA Astrophysics Data System (ADS)

Hermanne, A.; Adam Rebeles, R.; Tárkányi, F.; Takács, S.

2015-08-01

Thin natCr targets were obtained by electroplating, using 23.75 μm Cu foils as backings. In five stacked foil irradiations, followed by high resolution gamma spectroscopy, the cross sections for production of 52gFe, 49,51cumCr, 52cum,54,56cumMn and 48cumV in Cr and 61Cu,68Ga in Cu were measured up to 39 MeV incident α-particle energy. Reduced uncertainty is obtained by simultaneous remeasurement of the natCu(α,x)67,66Ga monitor reactions over the whole energy range. Comparisons with the scarce literature values and results from the TENDL-2013 on-line library, based on the theoretical code family TALYS-1.6, were made. A discussion of the production routes for 52gFe with achievable yields and contamination rates was made.

Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus.

PubMed

Ayuob, Nasra Naeim; El Wahab, Manal Galal Abd; Ali, Soad Shaker; Abdel-Tawab, Hanem Saad

2018-06-01

Alzheimer's disease (AD), one of the progressive neurodegenerative diseases might be associated with exposure to stress and altered living conditions. This study aimed to evaluate the effectiveness of Ocimum basilicum (OB) essential oils in improving the neurodegenerative-like changes induced in mice after exposed to chronic unpredictable mild stress (CUMS). Forty male Swiss albino mice divided into four groups (n = 10); the control, CUMS, CUMS + Fluoxetine, CUMS + OB were used. Behavioral tests, serum corticosterone level, hippocampus protein level of the glucocorticoid receptors (GRs) and brain-dreived neurotropic factor (BDNF) were determined after exposure to CUMS. Hippocampus was histopathologically examined. Data were analyzed using statistical package for the social sciences (SPSS) and P value of less than 0.05 was considered significant. OB diminished the depression manifestation as well as impaired short term memory observed in the mice after exposure to the CUMS as evidenced by the forced swimming and elevated plus maze test. OB also up-regulated the serum corticosterone level, hippocampal protein level of the glucocorticoid receptor and the brain-derived neurotropic factor and reduced the neurodegenerative and atrophic changes induced in the hippocampus after exposure to CUMS. Essential oils of OB alleviated the memory impairment and hippocampal neurodegenerative changes induced by exposure to the chronic unpredictable stress indicating that it is the time to test its effectiveness on patients suffering from Alzheimer disease.

Supersymmetry in the Jaynes-Cummings model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Castanos, Octavio

2013-06-12

A review is presented of the Darboux method and its relation to the supersymmetric quantum mechanics, together with the embedding of a n-dimensional scalar Hamiltonian into a supersymmetric matrix. It is also shown that the Jaynes-Cummings model, with or without rotating wave approximation, admit a supersymmetric quantum mechanics description.

A Stylistic Study on the Linguistic Deviations in E. E. Cummings' Poetry

ERIC Educational Resources Information Center

Li, Xin; Shi, Mengchen

2015-01-01

Regarded as the pioneer of experimental poetry, E. E. Cummings' unconventional treatment of poetic language has reached an unprecedented acme, which has intrigued and baffled numerous scholars, researchers and readers alike. Nevertheless, the very existence of poetry, like other types of literary texts, demonstrates the significance and value of…

Cummings Checklist of Characteristics of Gifted and Talented Children.

ERIC Educational Resources Information Center

Cummings, William B.

The Cummings Checklist of Characteristics of Gifted and Talented Children (CC) was evaluated with 516 elementary age pupils. Teachers used the checklist to nominate students for the gifted program. Ss were classified as either Test (IQ) Identified Gifted (TIG), Non-Test Identified Gifted (NTIG), or not classified. Results indicated that (1) the CC…

Emergence of traveling waves in the spreading of dengue fever

NASA Astrophysics Data System (ADS)

Bianco, Simone; Faatz, Andrea; Cummings, Derek; Shaw, Leah

2010-03-01

Dengue fever is a multistrain mosquito-borne subtropical disease that exhibits complex oscillatory outbreaks. Epidemiological data from Thailand displays traveling waves of infection originating in Bangkok, the largest population center (Cummings et al., Nature 427: 344, 2004). We present a multistrain metapopulation model in which traveling wave like behavior results from migration coupling between heterogeneous regions. The region with the highest effective person-to-person contact rate leads the dynamics. A stochastic version of the model will also be presented.

Xiaoyaosan Improves Depressive-Like Behaviors in Mice through Regulating Apelin-APJ System in Hypothalamus.

PubMed

Yan, Zhiyi; Jiao, Haiyan; Ding, Xiufang; Ma, Qingyu; Li, Xiaojuan; Pan, Qiuxia; Wang, Tingye; Hou, Yajing; Jiang, Youming; Liu, Yueyun; Chen, Jiaxu

2018-05-03

Background: The apelin-APJ system has been considered to play a crucial role in HPA axis function, and how the traditional Chinese compound prescription Xiaoyaosan regulates the apelin-APJ system as a supplement to treat depressive disorders. Objective: To investigate the depression-like behaviors and expression of apelin and APJ in hypothalamus of chronic unpredictable mild stress (CUMS) mice and study whether these changes related to the regulation of Xiaoyaosan. Methods: 60 adult C57BL/6J mice were randomly divided into four groups, including control group, CUMS group, Xiaoyaosan treatment group and fluoxetine treatment group. Mice in the control group and CUMS group received 0.5 mL physiological saline once a day by intragastric administration. Mice in two treatment groups received Xiaoyaosan (0.25 g/kg/d) and fluoxetine (2.6 mg/kg/d), respectively. After 21 days of modeling with CUMS, the expression of apelin and APJ in hypothalamus were measured by real-time fluorescence quantitative PCR, western blot and immunohistochemical staining. The physical condition, body weight, food intake and behavior tests such as open field test, sucrose preference test and force swimming test were measured to evaluate depressive-like behaviors. Results: In this study, significant behavioral changes were found in CUMS-induced mice, meanwhile the expressions of apelin and APJ in the hypothalamus were changed after modeling. The body weight, food-intake and depressive-like behaviors in CUMS-induced mice could be improved by Xiaoyaosan treatment which is similar with the efficacy of fluoxetine, while the expressions of apelin and APJ in hypothalamus were modified by Xiaoyaosan. Conclusions: The data suggest that apelin-APJ system changes in the hypothalamus may be a target of depressive disorders, and the beneficial effects of Chinese compound prescription Xiaoyaosan on depressive-like behaviors may be mediated by the apelin-APJ system.

High-Yield Preparation and Electrochemical Properties of Few-Layer MoS2 Nanosheets by Exfoliating Natural Molybdenite Powders Directly via a Coupled Ultrasonication-Milling Process

NASA Astrophysics Data System (ADS)

Dong, Huina; Chen, Deliang; Wang, Kai; Zhang, Rui

2016-09-01

Cost-effective and scalable preparation of two-dimensional (2D) molybdenum disulfide (MoS2) has been the bottleneck that limits their applications. This paper reports a novel coupled ultrasonication-milling (CUM) process to exfoliate natural molybdenite powders to achieve few-layer MoS2 (FL-MoS2) nanosheets in the solvent of N-methyl-2-pyrrolidone (NMP) with polyvinylpyrrolidone (PVP) molecules. The synergistic effect of ultrasonication and sand milling highly enhanced the exfoliation efficiency, and the precursor of natural molybdenite powders minimizes the synthetic cost of FL-MoS2 nanosheets. The exfoliation of natural molybdenite powders was conducted in a home-made CUM system, mainly consisting of an ultrasonic cell disruptor and a ceramic sand mill. The samples were characterized by X-ray diffraction, UV-vis spectra, Raman spectra, FT-IR, SEM, TEM, AFM, and N2 adsorption-desorption. The factors that influence the exfoliation in the CUM process, including the initial concentration of natural molybdenite powders ( C in, 15-55 g L-1), ultrasonic power ( P u, 200-350 W), rotation speed of sand mill ( ω s, 1500-2250 r.p.m), exfoliation time ( t ex, 0.5-6 h), and the molar ratio of PVP unit to MoS2 ( R pm, 0-1), were systematically investigated. Under the optimal CUM conditions (i.e., C in = 45 g L-1, P u = 280 W, ω s = 2250 r.p.m and R pm = 0.5), the yield at t ex = 6 h reaches 21.6 %, and the corresponding exfoliation rate is as high as 1.42 g L-1 h-1. The exfoliation efficiency of the CUM mode is much higher than that of either the ultrasonication (U) mode or the milling (M) mode. The synergistic mechanism and influencing rules of the CUM process in exfoliating natural molybdenite powders were elaborated. The as-obtained FL-MoS2 nanosheets have a high specific surface area of 924 m2 g-1 and show highly enhanced electrocatalytic performance in hydrogen evolution reaction and good electrochemical sensing property in detecting ascorbic acid. The CUM process developed has paved a low-cost, green, and highly efficient way towards FL-MoS2 nanosheets from natural molybdenite powders.

Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice.

PubMed

Li, Ze-Qun; Yan, Zhi-Yuan; Lan, Fu-Jun; Dong, Yi-Qun; Xiong, Ye

2018-07-02

Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm. CUMS up-regulated corticosterone (CORT) in serum, and down-regulated serotonin (5-HT), norepinephrine (NE) and brain-derived neurotrophic factor (BDNF) in hippocampus of mice, which were significantly reversed by NLGN3 deficiency. The results further demonstrated that NLGN3-knockout improved the degenerative neurons in cortex and hippocampus of CUMS-treated mice, accompanied with a significant decrease of ionized calciumbinding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) expressions. Additionally, NLGN3-KO mice challenged with CUMS showed a significant reduction of pro-inflammatory cytokines and chemokine, including tumor necrosis factor-alpha (TNF-α), interleukin-18 (IL-18), interleukin-1 beta (IL-1β), interleukin-4 (IL-4), CC-chemokine ligand-1 (CCL-1) and CXC-chemokine ligand-1 (CXCL-1), in cortex, hippocampus and amygdala tissue samples. Western blot analysis suggested that NLGN3-knockout inhibited the activation of nod-like receptor protein 3 (NLRP3) inflammasome and its adaptor of apoptosis-associated speck like protein (ASC), and reduced the expression of Caspase-1, along with the inactivation of nuclear factor-κB (NF-κB) in CUMS-challenged mice. The role of NLGN3 in regulating depression in mice was confirmed in vitro using astrocytes stimulated by LPS that NLGN3 knockdown reduced LPS-induced inflammation. Importantly, the suppressive effects of NLGN3-knockdown on inflammatory response were reversed by NLRP3 or ASC over-expression in AST exposed to LPS. In sum, our findings indicated that suppressing NLGN3 played a potential antidepressant role in CUMS animal model by inactivating NLRP3 inflammasome, providing a new therapeutic avenue for depression. Copyright © 2018. Published by Elsevier Inc.

Archean Pb Isotope Evolution: Implications for the Early Earth.

NASA Astrophysics Data System (ADS)

Vervoort, J. D.; Thorpe, R.; Albarede, F.; Blichert-Toft, J.

2008-12-01

The U-Pb isotope system provides us with a powerful tool for understanding the chemical evolution of the Earth. Pb isotopes in Archean rocks, however, have not been widely utilized because U mobility makes initial Pb isotope ratios from old silicate rocks difficult, if not impossible, to determine. Galenas in syngenetic volcanogenic massive sulfide (VMS) deposits, however, provide snapshots of initial Pb ratios because their Pb isotopic composition is time invariant at their formation (U/Pb=0). The Pb isotopic record from galenas from rocks of all age have been utilized for over 70 years to answer a wide range of scientific problems beginning with Al Nier's pioneering work analyzing Pb isotopes in the 1930's but are no longer widely used by the isotopic community because they have been produced by older TIMS techniques. We have begun a re-examination of Archean Pb by an extensive analysis of over 100 galena samples from Archean VMS deposits throughout the Superior and Slave Provinces in Canada as well as from other VMS deposits in Finland, South Africa and Western Australia. The goal of this work is to provide modern, high precision measurements and update an old, but venerable, Pb isotopic data set. We feel these data provide important constraints on not only the Pb isotopic evolution of the Earth, but planetary differentiation and recycling processes operating in the first 2 b.y. of Earth's history. Our analytical techniques include dissolving the Pb sulfide minerals, purifying them with ion chromatography, and analyzing them using MC-ICPMS at both Washington State University (Neptune) and Ecole Normale Superieure in Lyon, France (Nu). All Pb solutions are doped with Tl in order to correct for mass fractionation. In this abstract we report preliminary galena Pb isotope data from 6 VMS deposits in the Abitibi greenstone belt: Chibougamu, Matagami, Noranda, Normetal, Timmins, and Val d"Or. These deposits are all approximately 2.7 Ga in age but in detail vary from 2.728 Ga (Normetal) to 2.70 Ga (Noranda). The Pb isotopic compositions from these galenas, when normalized to a common age of 2.7 Ga, define a highly linear array in 207Pb/204Pb vs. 206Pb/204Pb. This array is nearly coincident with the 2.7 Ga geochron with a slope that corresponds to an age of ~4.4 Ga and with an extraordinary large range of 207Pb/204Pb, about the same magnitude as modern MORB. These data have important implications for the evolution of the Archean mantle. First, the slope of the Abitibi Pb-Pb array and its coincidence with the 2.7 Ga geochron suggests widespread U-Pb differentiation within the first hundred million years of Earth's history. This may have been due to either core formation or silicate/melt differentiation due to widespread melting of the mantle (e.g., formation of a magma ocean). Second, variations in μ in the Abitibi mantle and the subsequent Pb isotopic heterogeneities, whatever their cause, have not been significantly changed from 4.4 until 2.7 Ga. This implies that changes in μ in the Abitibi mantle source between 4.4 and 2.7 Ga, such as would be caused by crust extraction or recycling of older crust into this region of the mantle, were insufficient to destroy the original μ variations created at 4.4 Ga. Therefore, it appears that this portion of the mantle had essentially remained isolated and undisturbed from the early Hadean until the late Archean.

Institution's Title and Shibboleth: A Construct of Grammatical Relationship in Advertising Plates

ERIC Educational Resources Information Center

Dalamu, Taofeek

2017-01-01

Institutions are known through the names-cum-titles shown on their signboards, internet websites, letterheads, etc. However, it seems that such cultures could not satisfy the yearning of most organizations. So, they further propagate their core values and traits by constructing short linguistic bursts-cum-contents that can expatiate on what the…

Human-Centered Command and Control of Future Autonomous Systems

DTIC Science & Technology

2013-06-01

introduce challenges with situation awareness, automation reliance, and accountability (Bainbridge, 1983). If not carefully designed and integrated...into users’ tasks, automation’s costs can quickly outweigh its benefits. A tempting solution to compensate for inherent human cognitive limitations is... Drury & Scott, 2008; Nehme, Scott, Cummings, & Furusho, 2006; Scott & Cummings, 2006). However, there have not been detailed prescriptive task

40 CFR 90.711 - Suspension and revocation of certificates of conformity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the regulations of this part by testing as many engines as needed so that the CumSum statistic, as... continue introduction into commerce of a modified version of that family, the following actions must be... as many engines as needed from the modified engine family so that the CumSum statistic, as calculated...

40 CFR 91.511 - Suspension and revocation of certificates of conformity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... many engines as needed so that the CumSum statistic, as calculated in § 91.508(a), falls below the... family, if the manufacturer desires to continue introduction into commerce of a modified version of that... family so that the CumSum statistic, as calculated in § 91.508(a) using the newly assigned FEL if...

Analytical ground state for the Jaynes-Cummings model with ultrastrong coupling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Yuanwei; Institute of Theoretical Physics, Shanxi University, Taiyuan 030006; Chen Gang

2011-06-15

We present a generalized variational method to analytically obtain the ground-state properties of the Jaynes-Cummings model with the ultrastrong coupling. An explicit expression for the ground-state energy, which agrees well with the numerical simulation in a wide range of the experimental parameters, is given. In particular, the introduced method can successfully solve this Jaynes-Cummings model with the positive detuning (the atomic resonant level is larger than the photon frequency), which cannot be treated in the adiabatical approximation and the generalized rotating-wave approximation. Finally, we also demonstrate analytically how to control the mean photon number by means of the current experimentalmore » parameters including the photon frequency, the coupling strength, and especially the atomic resonant level.« less

Leaf insects from Luzon, Philippines, with descriptions of four new species, the new genus Pseudomicrophyllium, and redescription of Phyllium (Phyllium) geryon Gray, 1843, (Phasmida: Phylliidae).

PubMed

Cumming, Royce T; Leong, Jing V; Lohman, David J

2017-12-17

Examination of unidentified Phylliidae specimens revealed a number of undescribed species from the island of Luzon, Philippines. Morphological and molecular study of specimens from the obscure phasmid genus Microphyllium Zompro, 2001, revealed a new species, which we describe as Microphyllium haskelli Cumming sp. nov.. It is here described and differentiated from the two other species in the genus, both currently only known from adults of a single sex. Pseudomicrophyllium Cumming gen. nov. is described as a new genus within Phylliidae with the type species Pseudomicrophyllium faulkneri Cumming gen. et sp. nov. as the sole known species in the genus. As is unfortunately often the case in the leaf-mimicking family Phylliidae, this new genus and species is only known from a single specimen. In addition to the new genus, two new Phyllium (Phyllium) species from the siccifolium species-group are named and described as Ph. (Ph.) antonkozlovi Cumming sp. nov. and Ph. (Ph.) bourquei Cumming Le Tirant sp. nov.. In addition to the newly described species, Phyllium (Phyllium) geryon Gray, 1843 is redescribed from a nearly perfect specimen, completing some of the morphological knowledge gaps currently missing because of the severely damaged holotype specimen. A key to all known species of Phylliidae from Luzon is included. Holotype specimens for all four new species will be deposited in the National Museum of the Philippines type collection and paratype specimens will be deposited into the San Diego Natural History Museum collection or retained within the first author's collection.

Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system.

PubMed

Xia, Maosheng; Yang, Li; Sun, Guangfeng; Qi, Shuang; Li, Baoman

2017-02-01

Many studies have indicated that a history of depression increases the risk of developing Alzheimer's disease (AD); however, the potential pathogenestic mechanism by which depression functions as a high risk factor for AD remains unknown. Recently, a "cerebral lymphatic system" referred to as "glymphatic system" has been demonstrated to be responsible for neuronal extracellular waste protein clearance via a paravascular pathway. However, the function of glymphatic pathway has not been determined in depressive disorders. The present study used an animal model of chronic unpredictable mild stress (CUMS) to determine the function of glymphatic pathway by using fluorescence tracers. Immunohistochemistry was used to assess the accumulation of endogenous mouse and exogenous human amyloid beta 42 (Aβ42) in CUMS-treated mice with or without treatment with antidepressant fluoxetine. Glymphatic pathway circulation was impaired in mice treated with CUMS; moreover, glymphatic pathway dysfunction suppressed Aβ42 metabolism, because the accumulation of endogenous and exogenous Aβ42 was increased in the brains of the CUMS-treated mice. However, treatment with fluoxetine reversed these destructive effects of CUMS on glymphatic system. In anhedonic mice, the expression of the water channel aquaporin 4 (AQP4), a factor in glymphatic pathway dysfunction, was down-regulated in cortex and hippocampus. The dysfunction of glymphatic system suggested why a history of depression may be a strong risk factor for AD in anhedonic mice. We hope our study will contribute to an understanding of the risk mechanism of depressive disorder in the development of AD and the mechanisms of antidepressant therapies in AD.

Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster.

PubMed

Araujo, Stífani Machado; Poetini, Marcia Rósula; Bortolotto, Vandreza Cardoso; de Freitas Couto, Shanda; Pinheiro, Franciane Cabral; Meichtry, Luana Barreto; de Almeida, Francielli Polet; Santos Musachio, Elize Aparecida; de Paula, Mariane Trindade; Prigol, Marina

2018-05-24

The etiopathogenesis of depression may involve repeated exposure to several unpredictable stressors. This study was conducted to investigate changes induced by chronic unpredictable mild stress (CUMS) and to assess behavioral and neurochemical changes that predict depressive-like behavior in Drosophila melanogaster. Male Drosophila melanogaster flies were exposed to CUMS with several stressors (cold, heat, starvation, and sleep deprivation) in an unpredictable and chronic manner for ten days. At the end of treatment, in vivo behavioral tests (open field, aggression, forced swimming, mating, light/dark box, male fertility evaluation, sucrose preference, weight evaluation) and ex vivo analyses (dopamine and serotonin levels) were performed. Using this CUMS model, we obtained results that contribute to the construction of a depressive model in Drosophila, where we reproduce some behavioral phenotypes corresponding to depressive symptoms, such as immobility in the forced swimming test, less exploration in the light/dark test, changes in mating behavior, changes in the aggressiveness test, reduced sucrose preference, and weight-loss, in addition to a significant reduction in the levels of serotonin and dopamine when compared to the control group. Fluoxetine was used in our study as a positive control to demonstrate that CUMS-induced depressive-like behaviors in flies can be reversed by antidepressants. In conclusion, male Drosophila melanogaster exposed to CUMS display a depressive-like phenotype, and, while this poses some limitations as an animal model for depression, it meets some of the criteria required to be a valid model, such as good face and construct validity. Copyright © 2018. Published by Elsevier B.V.

High-Yield Preparation and Electrochemical Properties of Few-Layer MoS2 Nanosheets by Exfoliating Natural Molybdenite Powders Directly via a Coupled Ultrasonication-Milling Process.

PubMed

Dong, Huina; Chen, Deliang; Wang, Kai; Zhang, Rui

2016-12-01

Cost-effective and scalable preparation of two-dimensional (2D) molybdenum disulfide (MoS2) has been the bottleneck that limits their applications. This paper reports a novel coupled ultrasonication-milling (CUM) process to exfoliate natural molybdenite powders to achieve few-layer MoS2 (FL-MoS2) nanosheets in the solvent of N-methyl-2-pyrrolidone (NMP) with polyvinylpyrrolidone (PVP) molecules. The synergistic effect of ultrasonication and sand milling highly enhanced the exfoliation efficiency, and the precursor of natural molybdenite powders minimizes the synthetic cost of FL-MoS2 nanosheets. The exfoliation of natural molybdenite powders was conducted in a home-made CUM system, mainly consisting of an ultrasonic cell disruptor and a ceramic sand mill. The samples were characterized by X-ray diffraction, UV-vis spectra, Raman spectra, FT-IR, SEM, TEM, AFM, and N2 adsorption-desorption. The factors that influence the exfoliation in the CUM process, including the initial concentration of natural molybdenite powders (C in, 15-55 g L(-1)), ultrasonic power (P u, 200-350 W), rotation speed of sand mill (ω s, 1500-2250 r.p.m), exfoliation time (t ex, 0.5-6 h), and the molar ratio of PVP unit to MoS2 (R pm, 0-1), were systematically investigated. Under the optimal CUM conditions (i.e., C in = 45 g L(-1), P u = 280 W, ω s = 2250 r.p.m and R pm = 0.5), the yield at t ex = 6 h reaches 21.6 %, and the corresponding exfoliation rate is as high as 1.42 g L(-1) h(-1). The exfoliation efficiency of the CUM mode is much higher than that of either the ultrasonication (U) mode or the milling (M) mode. The synergistic mechanism and influencing rules of the CUM process in exfoliating natural molybdenite powders were elaborated. The as-obtained FL-MoS2 nanosheets have a high specific surface area of 924 m(2) g(-1) and show highly enhanced electrocatalytic performance in hydrogen evolution reaction and good electrochemical sensing property in detecting ascorbic acid. The CUM process developed has paved a low-cost, green, and highly efficient way towards FL-MoS2 nanosheets from natural molybdenite powders.

Quantum and classical chaos in kicked coupled Jaynes-Cummings cavities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayward, A. L. C.; Greentree, Andrew D.

2010-06-15

We consider two Jaynes-Cummings cavities coupled periodically with a photon hopping term. The semiclassical phase space is chaotic, with regions of stability over some ranges of the parameters. The quantum case exhibits dynamic localization and dynamic tunneling between classically forbidden regions. We explore the correspondence between the classical and quantum phase space and propose an implementation in a circuit QED system.

Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression.

PubMed

Qiao, Hui; An, Shu-Cheng; Xu, Chang; Ma, Xin-Ming

2017-05-15

Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays an important role in the structural plasticity induced by depression. Considering the opposite effects of BDNF and its precursor proBDNF on neural plasticity, we hypothesized that the balance of BDNF and proBDNF plays a critical role in chronic unpredicted mild stress (CUMS)-induced depressive-like behaviors and structural plasticity in the rodent hippocampus. The aims of this study were to compare the functions of BDNF and proBDNF in the CUMS-induced depressive-like behaviors, and determine the effects of BDNF and proBDNF on expressions of kalirin-7, postsynaptic density protein 95 (PSD95) and NMDA receptor subunit NR2B in the hippocampus of stressed and naïve control rats, respectively. Our results showed that CUMS induced depressive-like behaviors, caused a decrease in the ratio of BDNF/proBDNF in the hippocampus and resulted in a reduction in spine density in hippocampal CA1 pyramidal neurons; these alterations were accompanied by a decrease in the levels of kalirin-7, PSD95 and NR2B in the hippocampus. Injection of exogenous BDNF into the CA1 area of stressed rats reversed CUMS-induced depressive-like behaviors and prevented CUMS-induced spine loss and decrease in kalirin-7, NR2B and PSD95 levels. In contrast, injection of exogenous proBDNF into the CA1 region of naïve rats caused depressive-like behavior and an accompanying decrease in both spine density and the levels of kalirin-7, NR2B and PSD95. Taken together, our results suggest that the ratio of BDNF to proBDNF in the hippocampus plays a key role in CUMS-induced depressive-like behaviors and alterations of dendritic spines in hippocampal CA1 pyramidal neurons. Kalirin-7 may play an important role during this process. Copyright © 2017 Elsevier B.V. All rights reserved.

Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats.

PubMed

López-López, Ana Laura; Jaime, Herlinda Bonilla; Escobar Villanueva, María Del Carmen; Padilla, Malinalli Brianza; Palacios, Gonzalo Vázquez; Aguilar, Francisco Javier Alarcón

2016-07-01

Stress is considered to be a causal agent of chronic degenerative diseases, such as cardiovascular disease, diabetes mellitus, arthritis and Alzheimer's. Chronic glucocorticoid and catecholamine release into the circulation during the stress response has been suggested to activate damage mechanisms, which in the long term produce metabolic alterations associated with oxidative stress and inflammation. However, the consequences of stress in animal models for periods longer than 40days have not been explored. The goal of this work was to determine whether chronic unpredictable mild stress (CUMS) produced alterations in the redox state and the inflammatory profile of rats after 20, 40, and 60days. CUMS consisted of random exposure of the animals to different stressors. The following activities were measured in the liver and pancreas: reduced glutathione (GSH), lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and protein oxidation. Similarly, serum cytokine levels (IL-6, TNF-α, IL-1β, and IL-10) were determined. CUMS activated the stress response from day 20 until day 60. In the liver and pancreas, GHS levels were decreased from day 40, whereas protein lipid peroxidation and protein oxidation were increased. This is the first work to report that the pancreas redox state is subject to chronic stress conditions. The TAC was constant in the liver and reduced in the pancreas. An increase in the TNF-α, IL-1β, and IL-6 inflammatory markers and a decrease in the IL-10 level due to CUMS was shown, thereby resulting in the generation of a systemic inflammation state after 60days of treatment. Together, the CUMS consequences on day 60 suggest that both processes can contribute to the development of chronic degenerative diseases, such as cardiovascular disease and diabetes mellitus. CUMS is an animal model that in addition to avoiding habituation activates damage mechanisms such as oxidative stress and low-grade chronic inflammation, which allows the study of physio-pathological stress aspects over prolonged time periods of at least 60days. Copyright © 2016 Elsevier Inc. All rights reserved.

Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels.

PubMed

Stefanovic, Bojana; Spasojevic, Natasa; Jovanovic, Predrag; Jasnic, Nebojsa; Djordjevic, Jelena; Dronjak, Sladjana

2016-10-01

The hippocampus is sensitive to stress which activates norepinephrine terminals deriving from the locus coeruleus. Melatonin exerts positive effects on the hippocampal neurogenic process and on depressive-like behaviour. Thus, in the present study, an examination was made of the effect of chronic melatonin treatment on norepinephrine content, synthesis, uptake, vesicular transport and degradation in the hippocampus of rats exposed to CUMS. This entailed quantifying the norephinephrine, mRNA and protein levels of DBH, NET, VMAT 2, MAO-A and COMT. The results show that CUMS evoked prolonged immobility. Melatonin treatment decreased immobility in comparison with the placebo group, reflecting an antidepressant-like effect. Compared with the placebo group, a dramatic decrease in norepinephrine content, decreased VMAT2 mRNA and protein and increased MAO-A protein levels in the hippocampus of the CUMS rats were observed. However, no significant differences in the levels of DBH, NET, COMT mRNA and protein and MAO-A mRNA levels between the placebo and the stressed groups were found. The results showed the restorative effects of melatonin on the stress-induced decline in the norepinephrine content of the hippocampus. It was observed that melatonin treatment in the CUMS rats prevented the stress-induced decrease in VMAT2 mRNA and protein levels, whereas it reduced the increase of the mRNA of COMT and protein levels of MAO-A. Chronic treatment with melatonin failed to alter the gene expression of DBH or NET in the hippocampus of the CUMS rats. Additionally, the results show that melatonin enhances VMAT2 expression and norepinephrine storage, whilst it reduces norepinephrine degrading enzymes. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

Enhanced aggressive behaviour in a mouse model of depression.

PubMed

Yang, C R; Bai, Y Y; Ruan, C S; Zhou, H F; Liu, D; Wang, X F; Shen, L J; Zheng, H Y; Zhou, X F

2015-02-01

Depression is one of the most common chronic mental disorders, which is a leading cause of morbidity and mortality in patients. Depression often leads to offensive and defensive behaviours but the underlying mechanisms are not known. We propose that the aggressive behaviours in depression can be modelled in animal experiments. In this study, we successfully established a mouse model of depression using the chronic unpredictable mild stress (CUMS) paradigm and detected aggressive and social dominance behaviours in rodents by resident/intruder test and social dominance tube test (SDTT), respectively. The CUMS-exposed mice showed increased defensive, offensive and aggressive behaviours in the resident-intruder test. In the SDTT, these mice showed enhanced social dominance. These alterations were associated with reduced MAP-2 expression in the hippocampus while no difference in β-tubulin expression was detected. In addition, the treatment of anti-depressant fluoxetine reversed the aggressive behaviours without reducing the social dominance behaviour induced by CUMS. However, fluoxetine did effectively reverted the changes in MAP-2 expression in the hippocampus. In addition, the nonspecific tricyclic antipsychotic drug, clozapine, reversed all symptoms of CUMS-exposed mice including aggressive tendencies, impulsive violence, social dominance behaviour and MAP-2 expression in the hippocampus. The results suggests that social maladjustment such as competition and social dominance are likely related to the dopaminergic system rather than the serotonergic system and the hippocampal dendritic structure protein MAP-2. Thus, dominance can be separated from aggression. This study shows that aggression/hostility and social hierarchy/dominance are increased in the CUMS-exposed mice and thus provide an excellent model for further study in the diagnosis and the treatment of depression-associated aggression.

The Impacts of Heating Strategy on Soil Moisture Estimation Using Actively Heated Fiber Optics.

PubMed

Dong, Jianzhi; Agliata, Rosa; Steele-Dunne, Susan; Hoes, Olivier; Bogaard, Thom; Greco, Roberto; van de Giesen, Nick

2017-09-13

Several recent studies have highlighted the potential of Actively Heated Fiber Optics (AHFO) for high resolution soil moisture mapping. In AHFO, the soil moisture can be calculated from the cumulative temperature ( T cum ), the maximum temperature ( T max ), or the soil thermal conductivity determined from the cooling phase after heating ( λ ). This study investigates the performance of the T cum , T max and λ methods for different heating strategies, i.e., differences in the duration and input power of the applied heat pulse. The aim is to compare the three approaches and to determine which is best suited to field applications where the power supply is limited. Results show that increasing the input power of the heat pulses makes it easier to differentiate between dry and wet soil conditions, which leads to an improved accuracy. Results suggest that if the power supply is limited, the heating strength is insufficient for the λ method to yield accurate estimates. Generally, the T cum and T max methods have similar accuracy. If the input power is limited, increasing the heat pulse duration can improve the accuracy of the AHFO method for both of these techniques. In particular, extending the heating duration can significantly increase the sensitivity of T cum to soil moisture. Hence, the T cum method is recommended when the input power is limited. Finally, results also show that up to 50% of the cable temperature change during the heat pulse can be attributed to soil background temperature, i.e., soil temperature changed by the net solar radiation. A method is proposed to correct this background temperature change. Without correction, soil moisture information can be completely masked by the background temperature error.

Medical Surveillance Monthly Report (MSMR). Volume 5, Number 4, May 1999

DTIC Science & Technology

1999-05-01

Reporting Chlamydia Urethritis non-spec. Gonorrhea Syphilis Prim/Sec Syphilis Latent Syphilis Tertiary Syphilis Congenital MTF/Post** Cur. Cum. Cur. Cum...is prepared by the Army Medical Surveillance Activity , Directorate of Epidemiology and Disease Surveillance, United States Army Center for Health...Outbreak investigation: During the period 4 March to 8 April 1999, an Epidemiologic Consulta- tion (EPICON) team from the US Army Center for Health

Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.

PubMed

Ni, Yu-Fei; Wang, Hao; Gu, Qiu-Yan; Wang, Fei-Ying; Wang, Ying-Jie; Wang, Jin-Liang; Jiang, Bo

2018-04-01

Major depressive disorder has become one of the most serious neuropsychiatric disorders worldwide. However, currently available antidepressants used in clinical practice are ineffective for a substantial proportion of patients and always have side effects. Besides being a lipid-regulating agent, gemfibrozil is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the antidepressant effects of gemfibrozil on C57BL/6J mice using the forced swim test (FST) and tail suspension test (TST), as well as the chronic unpredictable mild stress (CUMS) model of depression. The changes in brain-derived neurotrophic factor (BDNF) signaling cascade in the brain after CUMS and gemfibrozil treatment were further assessed. Pharmacological inhibitors and lentivirus-expressed short hairpin RNA (shRNA) were also used to clarify the antidepressant mechanisms of gemfibrozil. Gemfibrozil exhibited significant antidepressant actions in the FST and TST without affecting the locomotor activity of mice. Chronic gemfibrozil administration fully reversed CUMS-induced depressive-like behaviors in the FST, TST and sucrose preference test. Gemfibrozil treatment also restored CUMS-induced inhibition of the hippocampal BDNF signaling pathway. Blocking PPAR-α and BDNF but not the serotonergic system abolished the antidepressant effects of gemfibrozil on mice. Gemfibrozil produced antidepressant effects in mice by promoting the hippocampal BDNF system.

Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat.

PubMed

Zhang, Yang; Gu, Fenghua; Chen, Jia; Dong, Wenxin

2010-12-17

Stress activates the hypothalamo-pituitary-adrenal (HPA) axis, regulates the expression of brain-derived neurotrophic factor (BDNF) in the brain, and mediates mood. Antidepressants alleviate stress and up-regulate BDNF gene expression. In this study, we investigated the effect of chronic unpredictable mild stress (CUMS) and the different kinds of antidepressant treatments on the HPA axis and the BDNF expression in the rat brain. Adult Wistar male rats were exposed to a six-week CUMS procedure and received different antidepressant treatments including venlafaxine, mirtazapine, and fluoxetine. Immunohistochemistry and real-time PCR were used to measure BDNF expression levels in the rat brain, and ELISAs were used to investigate the plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels. CUMS significantly decreased the BDNF protein level in the DG, CA1, and CA3 of the hippocampus and increased plasma CORT level. Chronic antidepressant treatments all significantly increased BDNF protein levels in the hippocampus and the pre-frontal cortex. In addition, venlafaxine and mirtazapine inhibited the increase of plasma CORT level. These results suggested that an increase in the BDNF level in the brain could be a pivotal mechanism of various antidepressants to exert their therapeutic effects. Copyright © 2010 Elsevier B.V. All rights reserved.

SOMA AS ENERGIZER-CUM-EUPHORIANT, VERSUS SURA, AN INTOXICANT

PubMed Central

Mahdihassan, S.

1984-01-01

Specific features of Soma plant are implict from various references in Rigveda enabling its identity as ephedra. Its juice is an energizer – cum – euphoriant contrary to the intoxicant sura. Sura is beer prepared from barely malt. Soma is the juice of ephedra rich in ephedrine which is antisomnalent. At least one use of soma has never been substituted, as the drink of longevity for a newly born child. PMID:22557400

π-tangle of a Jaynes-Cummings System and an Isolated Atom

NASA Astrophysics Data System (ADS)

Zhang, Hua-Ping; Qiang, Wen-Chao

2018-04-01

Using the π-tangle, we investigate entanglement properties of a quantum system consisted of a Jaynes-Cummings system and an isolated atom. We obtain analytical expressions of one-tangle, two-tangle and the π-tangle. Entanglement behaviors of the system are analyzed according to the analytical results. We find that the one-tangles have some relations with geometrical discord and entanglement sudden death never occurs in the total system.

Ladder operators and coherent states for the Jaynes-Cummings model in the rotating-wave approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hussin, V.; Nieto, L.M.

2005-12-15

Using algebraic techniques, we realize a systematic search of different types of ladder operators for the Jaynes-Cummings model in the rotating-wave approximation. The link between our results and previous studies on the diagonalization of the associated Hamiltonian is established. Using some of the ladder operators obtained before, examples are given on the possibility of constructing a variety of interesting coherent states for this Hamiltonian.

A generalized Jaynes-Cummings model: The relativistic parametric amplifier and a single trapped ion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ojeda-Guillén, D., E-mail: dojedag@ipn.mx; Mota, R. D.; Granados, V. D.

2016-06-15

We introduce a generalization of the Jaynes-Cummings model and study some of its properties. We obtain the energy spectrum and eigenfunctions of this model by using the tilting transformation and the squeezed number states of the one-dimensional harmonic oscillator. As physical applications, we connect this new model to two important and novelty problems: the relativistic parametric amplifier and the quantum simulation of a single trapped ion.

Experimental Preparation and Measurement of Quantum States of Motion of a Trapped Atom

DTIC Science & Technology

1997-01-01

trapped atom are quantum harmonic oscillators, their couplings to internal atomic levels (described by the Jaynes - Cummings model (JCM) [ l , 21) are... wave approximation in a frame rotating with WO, where hwo is the energy difference of the two internal levels, the interaction of the classical laser... Jaynes - Cummings model , the system is suited to realizing many proposals originally introduced in the realm of quantum optics and cavity quantum

Optics & Opto-Electronic Systems

DTIC Science & Technology

1988-06-01

its reflection by the 13 cavity boundaries, and its reabsorption by the atom. Multimode corrections to the single-mode Jaynes - Cummings model are...walls. Transients in the Micromaser C. R. Stroud, Jr. The Jaynes - Cummings model of a single two-lev3l atom interacting with a single field mode of a...increasing laser intensity and to be as large as 22 bits/sec. A standard model of self- pumped phase conjugation due to four- wave mixing has been

Experiments in Quantum Coherence and Computation With Single Cooper-Pair Electronics

DTIC Science & Technology

2006-01-22

through the cavity. In the absence of damping, exact diagonalization of the Jaynes - Cumming Hamiltonian yields the excited eigenstates (dressed states...neglecting rapidly oscillating terms and omitting damping for the moment, Eq. (16) reduces to the Jaynes - Cummings Hamiltonian (1) with V=EJ /" and cou...is therefore little entanglement between the field and qubit in this situation and the rotation fidelity is high. To model the effect of the drive on

Socioeconomic Considerations in Dam Safety Risk Analysis.

DTIC Science & Technology

1987-06-01

Rosenman, 1956; Wallace, 1956; Wolfenstein, 1957; Glass, 1959; Crawshaw , 1963; Farber, 1967; Lifton, 1967; Krystal, 1968; Kliman, 1973; Schulberg, 1974...Kasperson (eds.). Boulder, Colorado: Westview Press. Crawshaw , R. 1963. Reactions to Disaster. Archives of General Psychiatry 9:157-162. Cummings, R...T. 4, 119 Crawshaw , R. 46 Crook, L. 30 Crowe, W. 46 Cummings, R. G. 26 Dacy, D. 120 160 INDEX OF REFERENCES (Continued) D’Arge, R. 36 Davis, D. R

A note on approximate teleportation of an unknown atomic state in the two-photon Jaynes-Cummings model

NASA Astrophysics Data System (ADS)

dSouza, A. D.; Cardoso, W. B.; Avelar, A. T.; Baseia, B.

2009-04-01

We consider recent schemes [J.M. Liu, B. Weng, Physica A 367 (2006) 215] to teleport unknown atomic states and superposition of zero- and two-photon states using the two-photon Jaynes-Cummings model. Here we do the same using the “full two-photon Jaynes-Cumming”, valid for arbitrary average number of photons. The success probability and fidelity of this teleportation are also considered.

Application of the Simplified Dow Chemical Company Relative Ranking Hazard Assessment Method for Air Combat Command Bases

DTIC Science & Technology

1993-09-01

Chiras , Daniel D. Environmental Science . Redwood City, California: The Benjamin/Cummings Publishing Company, Inc., 1991. Cummings-Saxton, J., L...Engineering of the Air Force Institute of Technology Air University In Partial Fulfillment of the Requirements for the Degree of Master of Science in...Engineering and Environmental Management Raymond A. Sable, B. Architecture Captain, USAF, R.A. September 1993 Approved for public release; distribution

General integrable n-level, many-mode Janes-Cummings-Dicke models and classical r-matrices with spectral parameters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skrypnyk, T., E-mail: taras.skrypnyk@unimib.it, E-mail: tskrypnyk@imath.kiev.ua

Using the technique of classical r-matrices and quantum Lax operators, we construct the most general form of the quantum integrable “n-level, many-mode” spin-boson Jaynes-Cummings-Dicke-type hamiltonians describing an interaction of a molecule of N n-level atoms with many modes of electromagnetic field and containing, in general, additional non-linear interaction terms. We explicitly obtain the corresponding quantum Lax operators and spin-boson analogs of the generalized Gaudin hamiltonians and prove their quantum commutativity. We investigate symmetries of the obtained models that are associated with the geometric symmetries of the classical r-matrices and construct the corresponding algebra of quantum integrals. We consider in detailmore » three classes of non-skew-symmetric classical r-matrices with spectral parameters and explicitly obtain the corresponding quantum Lax operators and Jaynes-Cummings-Dicke-type hamiltonians depending on the considered r-matrix.« less

Emergent Properties Delineate Marine Ecosystem Perturbation and Recovery.

PubMed

Link, Jason S; Pranovi, Fabio; Libralato, Simone; Coll, Marta; Christensen, Villy; Solidoro, Cosimo; Fulton, Elizabeth A

2015-11-01

Whether there are common and emergent patterns from marine ecosystems remains an important question because marine ecosystems provide billions of dollars of ecosystem services to the global community, but face many perturbations with significant consequences. Here, we develop cumulative trophic patterns for marine ecosystems, featuring sigmoidal cumulative biomass (cumB)-trophic level (TL) and 'hockey-stick' production (cumP)-cumB curves. The patterns have a trophodynamic theoretical basis and capitalize on emergent, fundamental, and invariant features of marine ecosystems. These patterns have strong global support, being observed in over 120 marine ecosystems. Parameters from these curves elucidate the direction and magnitude of marine ecosystem perturbation or recovery; if biomass and productivity can be monitored effectively over time, such relations may prove to be broadly useful. Curve parameters are proposed as possible ecosystem thresholds, perhaps to better manage the marine ecosystems of the world. Published by Elsevier Ltd.

Archaean lode gold deposits: the solute source problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerrich, R.

1985-01-01

On a regional scale lode gold deposits typically occur throughout the entire spectrum of greenstone belt stratigraphy. In the Abitibi Belt lode deposits are sited at the base of the volcanic cycle (Noranda), at the boundary of two volcanic cycles (Timmins) and in the stratigraphically highest groups at Kirkland Lake and Bousquet. The gold deposits are preferentially disposed along major structures apparently demarking rift zones, where extension was accommodated by listric normal faults that subsequently acted as thrusts during compression. These major structures were also sites of emplacement of trondhjemite magmas, lamprophyres and potassic basalts. From previous work Abitibi Beltmore » volcanism spans 2725 to 2703 Ma, batholith emplacement 2675 to 2685 Ma (U-Pb on zircons), and the terminal Matachewan dyke swarm which transects all major structures is 2690 +/- 93 Ma. The lode deposits have age corrected /sup 87/Sr//sup 86/Sr initials of 0.7015 to 0.7025, as well as more radiogenic Pb and higher ..mu.. relative to contemporaneous mantle Sr and Pb isotope ratios. Tourmaline, scheelite, piemontite and apatites separated from 14 deposits all possess /sup 87/Sr//sup 86/Sr 0.7015 to 0.7025. These more radiogenic values contra-indicate a direct mantle source for Sr and Pb, but rather indicate that all mineralizing fluids carry contributions from a felsic crustal source having a significant production of Rb, U and Th radiogenic daughter nuclides as well as from komatiites and tholeiites. Gold, along with an array of lithophile elements including K, Rb, Pb, Li, Sr and CO/sub 2/ were distilled from this mixed source.« less

Two-polariton bound states in the Jaynes-Cummings-Hubbard model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wong, Max T. C.; Law, C. K.

2011-05-15

We examine the eigenstates of the one-dimensional Jaynes-Cummings-Hubbard model in the two-excitation subspace. We discover that two-excitation bound states emerge when the ratio of vacuum Rabi frequency to the tunneling rate between cavities exceeds a critical value. We determine the critical value as a function of the quasimomentum quantum number, and indicate that the bound states carry a strong correlation in which the two polaritons appear to be spatially confined together.

Catch-Disperse-Release Readout for Superconducting Qubits

DTIC Science & Technology

2013-03-01

adiabatic, a fast high-fidelity qubit readout is possible even in the strongly nonlinear dispersive regime. Interestingly, the Jaynes - Cummings nonlinearity...will be included later) and describe the system by the Jaynes - Cummings (JC) Hamiltonian [7] with a microwave drive (we use ~ = 1) H = ωq(t)σ+σ− + ωra...λeff,0 rotates on the phase plane faster than in the two-level approximation , while λeff,1 rotates slower (some- times even in the opposite

X-linked ocular albinism in Blacks. Ocular albinism cum pigmento.

PubMed

O'Donnell, F E; Green, W R; Fleischman, J A; Hambrick, G W

1978-07-01

X-linked ocular albinism can be an unsuspected cause of congenital nystagmus in blacks. In this study, eight of ten black ocular albinos from two kindreds had nonalbinotic, moderately pigmented fundi and no transillumination of the iris. We refer to this paradoxical condition as "ocular albinism cum pigmento." The only constant ophthalmoscopic feature was a foveal hypoplasia. Biopsy of clinically normal skin to demonstrate giant pigment granules is the most accurate means of diagnosis.

An investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics.

PubMed

Gao, Xiao-Xia; Cui, Jie; Zheng, Xing-Yu; Li, Zhen-Yu; Choi, Young-Hae; Zhou, Yu-Zhi; Tian, Jun-Sheng; Xing, Jie; Tan, Xiao-Jie; Du, Guan-Hua; Qin, Xue-Mei

2013-07-01

A rapid, highly sensitive, and selective method was applied in a non-invasive way to investigate the antidepressant action of Xiaoyaosan (XYS) using ultra performance liquid chromatography-mass spectrometry (UPLC-MS) and chemometrics. Many significantly altered metabolites were used to explain the mechanism. Venlafaxine HCl and fluoxetine HCl were used as chemical positive control drugs with a relatively clear mechanism of action to evaluate the efficiency and to predict the mechanism of action of XYS. Urine obtained from rats subjected to chronic unpredictable mild stress (CUMS) was analyzed by UPLC-MS. Distinct changes in the pattern of metabolites in the rat urine after CUMS production and drug intervention were observed using partial least squares-discriminant analysis. The results of behavioral tests and multivariate analysis showed that CUMS was successfully reproduced, and a moderate-dose XYS produced significant therapeutic effects in the rodent model, equivalent to those of the positive control drugs, venlafaxine HCl and fluoxetine HCl. Metabolites with significant changes induced by CUMS were identified, and 17 biomarker candidates for stress and drug intervention were identified. The therapeutic effect of XYS on depression may involve regulation of the dysfunctions of energy metabolism, amino acid metabolism, and gut microflora changes. Metabonomic methods are valuable tools for measuring efficacy and mechanisms of action in the study of traditional Chinese medicines. Copyright © 2012 John Wiley & Sons, Ltd.

Geochemical characteristics of aluminum depleted and undepleted komatiites and HREE-enriched low-Ti tholeiites, western Abitibi greenstone belt: A heterogeneous mantle plume-convergent margin environment

NASA Astrophysics Data System (ADS)

Fan, J.; Kerrich, R.

1997-11-01

A compositionally diverse suite of komatiites, komatiitic basalts, and basalts coexist in the Tisdale volcanic assemblage of the late-Archean (˜2.7 Ga) Abitibi greenstone belt. The komatiites are characterized by a spectrum of REE patterns, from low total REE contents (9 ppm) and pronounced convex-up patterns to greater total REE (18 ppm) and approximately flat-distributions. Thorium and niobium are codepleted with LREE. Komatiites with the most convex-up patterns have low Al 2O 3 (4.7 wt%) contents and Al 2O 3/TiO 2(12) ratios; they are interpreted to be the Al-depleted variety of komatiite derived from a depleted mantle source. Those komatiites and komatiitic basalts with flatter REE patterns are characterized by greater Al 2O 3 (7.0 wt%) and near chondritic Al 2O 3/TiO 2 (20) ratios; they are interpreted to be Al-undepleted komatiites generated from trace element undepleted mantle. For the komatiites and komatiitic basalts collectively, Gd/Ybn ratios are negatively correlated with La/Smn, but positively with MgO and Ni. The spectrum of patterns is interpreted as mixing between Al, HREE, Y-depleted, and Sc-depleted komatiites and Al-undepleted komatiites in a heterogeneous mantle plume. Auminum-depleted komatiites are characterized by negative Zr and Hf anomalies, consistent with majorite garnet-liquid D's for HFSE and REEs, signifying melt segregation at depths of >400 km. Tisdale Al-undepleted komatiites and komatiitic basalts have small negative to zero Zr(Hf)/MREE fractionation, signifying melt segregation in or above the garnet stability field. Collectively, the komatiites have correlations of Zr/Zr∗ and Hf/Hf ∗ with Gd/Ybn, and hence the Zr(Hf)/MREE fractionations are unlikely to have stemmed from alteration or crustal contamination. Two types of basalts are present. Type I basalts are Mg-tholeiites with near flat REE and primitive mantle normalized patterns, compositionally similar to abundant Mg-tholeiites associated with both Al-undepleted and Al-depleted komatiites in the Abitibi belt. They have absolute concentrations and ratios of most moderately and highly compatible elements comparable to N- MORB (Zr ˜79 vs. 74, Y ˜30 vs. 28, and Zr/Y = 2.4-2.9 vs. 2.6 ), but are relatively less depleted in highly incompatible elements and lack positive Nb or P anomalies. Type II basalts are relatively aluminous (Al 2O 3 ˜ 16 wt%), with high Al 2O 3/TiO 2 (24-28) ratios. They are characterized by low Th, Nb, and LREE contents at eight to ten times chondrite, with slightly convex-up LREE patterns ( La/Smn = 0.86-0.99 ), but strongly fractionated and enriched HREEs, Y, and Sc, where Gd/Ybn = 0.50-0.55 and consistently positive Zr(Hf)/MREEs anomalies. These basalts are tentatively interpreted as low-Ti tholeiites formed in a convergent margin setting with second stage melting, induced by fluids and melts enriched in incompatible elements and Zr(Hf) relative to MREEs, of a mantle source depleted during first stage melting. They are analogous to the Phanerozoic low-Ti tholeiite - boninite association. Accordingly the Tisdale volcanic sequence records a plume-convergent margin interaction. New analyses of Al-undepleted komatiites from the classical locality at Pyke Hill in Munro Township confirm the presence of small positive anomalies of P, Zr, and Hf, with Zr/Hf ratios generally < 36. These signatures are similar in spinifex and cumulate zones signifying that they are unlikely to have resulted from alteration. The data were generated by INAA and ICP-MS using both HFHNO 3 dissolution and Na 2O 2 sinter. The lack of LREE enrichment with negative Nb, Ta, P, and Ti anomalies in any of the Tisdale or Munro komatiites confirms an intraoceanic setting for the volcanic stage of the Western Abitibi greenstone belt.

Generalized Tavis-Cummings models and quantum networks

NASA Astrophysics Data System (ADS)

Gorokhov, A. V.

2018-04-01

The properties of quantum networks based on generalized Tavis-Cummings models are theoretically investigated. We have calculated the information transfer success rate from one node to another in a simple model of a quantum network realized with two-level atoms placed in the cavities and interacting with an external laser field and cavity photons. The method of dynamical group of the Hamiltonian and technique of corresponding coherent states were used for investigation of the temporal dynamics of the two nodes model.

Dynamics of atom-field entanglement for Tavis-Cummings models

NASA Astrophysics Data System (ADS)

Bashkirov, Eugene K.

2018-04-01

An exact solution of the problem of two-atom one- and two-mode Jaynes-Cummings model with intensity- dependent coupling is presented. Asymptotic solutions for system state vectors are obtained in the approximation of large initial coherent fields. The atom-field entanglement is investigated on the basis of the reduced atomic entropy dynamics. The possibility of the system being initially in a pure disentangled state to revive into this state during the evolution process for both models is shown. Conditions and times of disentanglement are derived.

Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain.

PubMed

Li, Ruipeng; Wang, Xiangxiang; Qin, Tingting; Qu, Rong; Ma, Shiping

2016-01-01

Increasing evidence suggests that inflammation and oxidative stress may contribute to the development of major depressive disorder (MDD). Apigenin, a type of bioflavonoid widely found in citrus fruits, has a number of biological actions including anti-inflammatory and antioxidant effects. Although apigenin has potential antidepressant activity, the mechanisms of this effect remain unclear. The present study aims to investigate the effects of apigenin on behavioral changes and inflammatory responses induced by chronic unpredictable mild stress (CUMS) in rats. GW9662, a selective peroxisome proliferator-activated receptor gamma (PPARγ) inhibitor, was administered 30 min before apigenin. We found that treatment with apigenin (20mg/kg, intragastrically) for three weeks remarkably ameliorated CUMS-induced behavioral abnormalities, such as decreased locomotor activity and reduced sucrose consumption. In response to oxidative stress, the NLRP3 inflammasome was activated and IL-1β secretion increased in the prefrontal cortex (PFC) of CUMS rats. However, apigenin treatment upregulated PPARγ expression and downregulated the expression of NLRP3, which subsequently downregulated the production of IL-1β. In addition, GW9662 diminished the inhibitory effects of apigenin on the NLRP3 inflammasome. In conclusion, our results demonstrate that apigenin exhibits antidepressant-like effects in CUMS rats, possibly by inhibiting IL-1β production and NLRP3 inflammasome expression via the up-regulation of PPARγ expression. Copyright © 2015. Published by Elsevier B.V.

Variability of African Farming Systems from Phenological Analysis of NDVI Time Series

NASA Technical Reports Server (NTRS)

Vrieling, Anton; deBeurs, K. M.; Brown, Molly E.

2011-01-01

Food security exists when people have access to sufficient, safe and nutritious food at all times to meet their dietary needs. The natural resource base is one of the many factors affecting food security. Its variability and decline creates problems for local food production. In this study we characterize for sub-Saharan Africa vegetation phenology and assess variability and trends of phenological indicators based on NDVI time series from 1982 to 2006. We focus on cumulated NDVI over the season (cumNDVI) which is a proxy for net primary productivity. Results are aggregated at the level of major farming systems, while determining also spatial variability within farming systems. High temporal variability of cumNDVI occurs in semiarid and subhumid regions. The results show a large area of positive cumNDVI trends between Senegal and South Sudan. These correspond to positive CRU rainfall trends found and relate to recovery after the 1980's droughts. We find significant negative cumNDVI trends near the south-coast of West Africa (Guinea coast) and in Tanzania. For each farming system, causes of change and variability are discussed based on available literature (Appendix A). Although food security comprises more than the local natural resource base, our results can perform an input for food security analysis by identifying zones of high variability or downward trends. Farming systems are found to be a useful level of analysis. Diversity and trends found within farming system boundaries underline that farming systems are dynamic.

Concurrence of three Jaynes-Cummings systems

NASA Astrophysics Data System (ADS)

Qiang, Wen-Chao; Sun, Guo-Hua; Dong, Qian; Camacho-Nieto, Oscar; Dong, Shi-Hai

2018-04-01

We apply genuine multipartite concurrence to investigate entanglement properties of three Jaynes-Cummings systems. Three atoms are initially put in GHZ-like state and locally interact with three independent cavities, respectively. We present analytical concurrence expressions for various subsystems including three-atom, three-cavity and some atom-cavity mixed systems. We also examine the global system and illustrate the evolution of its concurrence. Except for the sudden death of entanglement, we find for some initial entanglement parameter θ , the concurrence of the global system may maintain unchanged in some time intervals.

Round Table Workshop on the Frontiers of Condensed Matter Physics Held in Broomcroft Hall, Manchester on 24-25 September 1990

DTIC Science & Technology

1990-12-01

Jaynes - Cummings model (describing a two-level atom in a radiant cavity), in which the interaction between atom and radiation field is non- linearly...dependent on the field intensity [14]. It is interesting to notice that such an application was fostered by the observation that the Jaynes - Cummings model in...ai i an anilation operator of the radition field and .o is a spin operator of an electron wave function, can be approximated by the product <a,,> ɜ"V

Cavity losses for the dissipative Jaynes Cummings Hamiltonian beyond rotating wave approximation

NASA Astrophysics Data System (ADS)

Scala, M.; Militello, B.; Messina, A.; Maniscalco, S.; Piilo, J.; Suominen, K.-A.

2007-11-01

A microscopic derivation of the master equation for the Jaynes-Cummings model with cavity losses is given, taking into account the terms in the dissipator which vary with frequencies of the order of the vacuum Rabi frequency. Our approach allows us to single out physical contexts wherein the usual phenomenological dissipator turns out to be fully justified and constitutes an extension of our previous analysis (Scala et al 2007 Phys. Rev. A 75 013811), where a microscopic derivation was given in the framework of the rotating wave approximation.

High-fidelity readout in circuit quantum electrodynamics using the Jaynes-Cummings nonlinearity.

PubMed

Reed, M D; DiCarlo, L; Johnson, B R; Sun, L; Schuster, D I; Frunzio, L; Schoelkopf, R J

2010-10-22

We demonstrate a qubit readout scheme that exploits the Jaynes-Cummings nonlinearity of a superconducting cavity coupled to transmon qubits. We find that, in the strongly driven dispersive regime of this system, there is the unexpected onset of a high-transmission "bright" state at a critical power which depends sensitively on the initial qubit state. A simple and robust measurement protocol exploiting this effect achieves a single-shot fidelity of 87% using a conventional sample design and experimental setup, and at least 61% fidelity to joint correlations of three qubits.

Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats.

PubMed

Abuelezz, Sally A; Hendawy, Nevien; Magdy, Yosra

2017-06-01

Depression is a major health problem in which oxidative stress and inflammation are inextricably connected in its pathophysiology. Coenzyme Q10 (CoQ10) is an important anti-oxidant compound with anti-inflammatory and neuro-protective properties. This study was designed to investigate the hypothesis that CoQ10 by its anti-oxidant and anti-inflammatory potentials can alleviate depressive- like behavior by restoring the balance of the tryptophan catabolites kynurenine/serotonin toward the serotonin pathway by down-regulation of hippocampal indoleamine 2,3-dioxygenase 1 (IDO-1). Depressive-like behavior was induced by chronic unpredictable mild stress (CUMS) protocol including food or water deprivation, cage tilting, reversed light cycle etc. Male Wistar rats were randomly divided into five groups; Control, CUMS, CUMS and CoQ10 (50,100 and 200 mg/kg/day i.p. respectively) groups. CoQ10 effects on different behavioral and biochemical tests were analyzed. CoQ10 showed significant antidepressant efficacy, as evidenced by significantly decreased stress induced changes to forced swimming challenge and open field test, as well as attenuating raised corticosterone level and adrenal glands weight. The anti-oxidant effect of CoQ10 was exhibited by its ability to significantly reduce hippocampal elevated malondialdehyde and 4-hydroxynonenal levels and elevate the reduced glutathione and catalase levels. CoQ10 significantly reduced different pro-inflammatory cytokines levels including interleukin (IL)-1β, IL-2, IL-6 and tumor necrosis factor-α. It suppressed hippocampal IDO-1 and subsequent production of kynurenine and enhanced the hippocampal contents of tryptophan and serotonin. Immunohistochemical analysis revealed that CoQ10 was able to attenuate the elevated microglial CD68 and elevate the astrocyte glial fibrillary acidic protein compared to CUMS group. CoQ10 exhibited antidepressant-like effects on rats exposed to CUMS. This could be attributed to its ability to reduce IDO-1 leading to shift the balance of the Kynurenine/ serotonin toward the serotonin pathway.

Potential of EPR spin-trapping to investigate in situ free radicals generation from skin allergens in reconstructed human epidermis: cumene hydroperoxide as proof of concept.

PubMed

Kuresepi, Salen; Vileno, Bertrand; Turek, Philippe; Lepoittevin, Jean-Pierre; Giménez-Arnau, Elena

2018-02-01

The first step in the development of skin sensitisation to a chemical, and in the elicitation of further allergic contact dermatitis (ACD), is the binding of the allergen to skin proteins after penetrating into the epidermis. The so-formed antigenic adduct is then recognised by the immune system as foreign to the body. Sensitising organic hydroperoxides derived from autoxidation of natural terpenes are believed to form antigens through radical-mediated mechanisms, although this has not yet been established. So far, in vitro investigations on reactive radical intermediates derived from these skin sensitisers have been conducted in solution, yet with experimental conditions being far away from real-life sensitisation. Herein, we report for the first time, the potential use of EPR spin-trapping to study the in situ generation of free radicals derived from cumene hydroperoxide CumOOH in a 3D reconstructed human epidermis (RHE) model, thus much closer to what may happen in vivo. Among the undesirable effects associated with dermal exposure to CumOOH, it is described to cause allergic and irritant dermatitis, being reported as a significant sensitiser. We considered exploiting the usage of spin-trap DEPMPO as an extensive view of all sort of radicals derived from CumOOH were observed all at once in solution. We showed that in the Episkin TM RHE model, both by incubating in the assay medium and by topical application, carbon radicals are mainly formed by redox reactions suggesting the key role of CumOOH-derived carbon radicals in the antigen formation process.

Ghrelin alleviates anxiety- and depression-like behaviors induced by chronic unpredictable mild stress in rodents.

PubMed

Huang, Hui-Jie; Zhu, Xiao-Cang; Han, Qiu-Qin; Wang, Ya-Lin; Yue, Na; Wang, Jing; Yu, Rui; Li, Bing; Wu, Gen-Cheng; Liu, Qiong; Yu, Jin

2017-05-30

As a regulator of food intake, ghrelin also plays a key role in mood disorders. Previous studies reported that acute ghrelin administration defends against depressive symptoms of chronic stress. However, the effects of long-term ghrelin on rodents under chronic stress hasn't been revealed. In this study, we found chronic peripheral administration of ghrelin (5nmol/kg/day for 2 weeks, i.p.) could alleviate anxiety- and depression-like behaviors induced by chronic unpredictable mild stress (CUMS). The depression-like behaviors were assessed by the forced swimming test (FST), and anxiety-like behaviors were assessed by the open field test (OFT) and the elevated plus maze test (EPM). Meanwhile, we observed that peripheral acylated ghrelin, together with gastral and hippocampal ghrelin prepropeptide mRNA level, were significantly up-regulated in CUMS mice. Besides, the increased protein level of growth hormone secretagogue receptor (GHSR) in hippocampus were also detected. These results suggested that the endogenous ghrelin/GHSR pathway activated by CUMS plays a role in homeostasis. Further results showed that central treatment of ghrelin (10μg/rat/day for 2 weeks, i.c.v.) or GHRP-6 (the agonist of GHSR, 10μg/rat/day for 2 weeks, i.c.v.) significantly alleviated the depression-like behaviors induced by CUMS in FST and sucrose preference test (SPT). Based on these results, we concluded that central GHSR is involved in the antidepressant-like effect of exogenous ghrelin treatment, and ghrelin/GHSR may have the inherent neuromodulatory properties against depressive symptoms. Copyright © 2017 Elsevier B.V. All rights reserved.

The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus

PubMed Central

Wang, Nan; Yu, Hai-Ying; Shen, Xiao-Feng; Gao, Zhi-Qin; Yang, Chun; Yang, Jian-Jun

2015-01-01

Objectives. Active inflammatory responses play an important role in the pathogenesis of depression. We hypothesized that the rapid antidepressant effect of ketamine is associated with the down-regulation of pro-inflammatory mediators. Methods. Forty-eight rats were equally randomized into six groups (a control and five chronic unpredictable mild stress (CUMS) groups) and given either saline or 10 mg/kg ketamine, respectively. The forced swimming test was performed, and the hippocampus was subsequently harvested for the determination of levels of interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), indoleamine 2,3-dioxygenase (IDO), kynurenine (KYN), and tryptophan (TRP). Results. CUMS induced depression-like behaviours and up-regulated the hippocampal levels of IL-1β, IL-6, TNF-α, IDO, and the KYN/TRP ratio, which were attenuated by a sub-anaesthetic dose of ketamine. Conclusion. CUMS-induced depression-like behaviours are associated with a reduction in hippocampal inflammatory mediators, whereas ketamine’s antidepressant effect is associated with a down-regulation of pro-inflammatory cytokines in the rat hippocampus. PMID:26220286

Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression.

PubMed

Liu, Ya-Min; Hu, Chun-Yue; Shen, Ji-Duo; Wu, Su-Hui; Li, Yu-Cheng; Yi, Li-Tao

2017-02-01

Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components. It has been demonstrated that ferulic acid can reverse depressive-like behaviors in both forced swimming test and tail suspension test. However, it is unclear whether chronic ferulic acid treatment can ameliorate the depressive-like behaviors in chronic unpredictable mild stress (CUMS). Because of the putative relationship between neurotrophic system and antidepressant-like activity, we also investigated the effects of chronic ferulic acid on the brain-derived neurotrophic factor (BDNF), postsynaptic protein PSD95, presynaptic protein synapsin I in both prefrontal cortex and hippocampus. The results showed that ferulic acid significantly alleviated CUMS-induced depressive-like behaviors in sucrose preference test and forced swimming test. In addition, ferulic acid significantly up-regulated the levels of BDNF, PSD95 and synapsin I in the prefrontal cortex and hippocampus. The present data indicated that ferulic acid exerted the antidepressant-like effects on behaviors by increasing neurotrophin-related synaptic protein levels in CUMS mice. Copyright © 2016. Published by Elsevier Inc.

Exact mapping of the 2+1 Dirac oscillator onto the Jaynes-Cummings model: Ion-trap experimental proposal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bermudez, A.; Martin-Delgado, M. A.; Solano, E.

2007-10-15

We study the dynamics of the 2+1 Dirac oscillator exactly and find spin oscillations due to a Zitterbewegung of purely relativistic origin. We find an exact mapping of this quantum-relativistic system onto a Jaynes-Cummings model, describing the interaction of a two-level atom with a quantized single-mode field. This equivalence allows us to map a series of quantum optical phenomena onto the relativistic oscillator and vice versa. We make a realistic experimental proposal, in reach with current technology, for studying the equivalence of both models using a single trapped ion.

Non-Markovianity of the damped Jaynes-Cummings model with detuning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Jungang; Zou Jian; Shao Bin

2010-06-15

The degree of non-Markovian behavior of a damped Jaynes-Cummings model with detuning is investigated. Our attention is focused on the effects of the detuning and the width of the Lorentzian spectral density on the degree of non-Markovian behavior. It is found that an increase of the detuning can make the information exchange between the qubit and the reservoir more rapid, and this leads to an increase in the degree of non-Markovianity for some cases, while an increase of the spectral width always leads to a decrease in the degree of non-Markovianity.

Vacuum-induced Berry phases in single-mode Jaynes-Cummings models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yu; Wei, L. F.; Jia, W. Z.

2010-10-15

Motivated by work [Phys. Rev. Lett. 89, 220404 (2002)] for detecting the vacuum-induced Berry phases with two-mode Jaynes-Cummings models (JCMs), we show here that, for a parameter-dependent single-mode JCM, certain atom-field states also acquired photon-number-dependent Berry phases after the parameter slowly changed and eventually returned to its initial value. This geometric effect related to the field quantization still exists, even if the field is kept in its vacuum state. Specifically, a feasible Ramsey interference experiment with a cavity quantum electrodynamics system is designed to detect the vacuum-induced Berry phase.

Landau-Zener extension of the Tavis-Cummings model: Structure of the solution

DOE PAGES

Sun, Chen; Sinitsyn, Nikolai A.

2016-09-07

We explore the recently discovered solution of the driven Tavis-Cummings model (DTCM). It describes interaction of an arbitrary number of two-level systems with a bosonic mode that has linearly time-dependent frequency. We derive compact and tractable expressions for transition probabilities in terms of the well-known special functions. In this form, our formulas are suitable for fast numerical calculations and analytical approximations. As an application, we obtain the semiclassical limit of the exact solution and compare it to prior approximations. Furthermore, we also reveal connection between DTCM and q-deformed binomial statistics.

Nutrient Intakes and Work Performance of Soldiers during Seven Days of Exercise at 7,200 Feet Ready-to-Eat Ration

DTIC Science & Technology

1986-09-19

100.000 *4 • D " ",4.. .4.’-’ FrteiuEncy of M1aE Fouds Consumed CLASS=khJlTS FCOOD NAM~E FOOD FREQUENCY CUM? FaL1 £EjcENlI CUM PER~CENT APPLESAUCE ...4 1/2 3/4 all JELLY 1/4 1/2 3/4 all PEANUT BUTTER 1/4 1/2 3/4 all FRUIT APPLESAUCE 1/4 1/2 3/4 all MIXED FRUITS 1/4 1/2 3/4 all PEACHES 1/4 1/2 3/4

Demonstration of the Jaynes-Cummings ladder with Rydberg-dressed atoms

DOE PAGES

Lee, Jongmin; Martin, Michael J.; Jau, Yuan-Yu; ...

2017-04-06

Here, we observe the nonlinearity of the Jaynes-Cummings (JC) ladder in the Autler-Townes spectroscopy of the hyperfine ground states for a Rydberg-dressed two-atom system. The role of the two-level system in the JC model is played by the presence or absence of a collective Rydberg excitation, and the bosonic mode manifests as the number n of single-atom spin flips, symmetrically distributed between the atoms. We also measure the normal-mode splitting and √ n nonlinearity as a function of detuning and Rabi frequency, thereby experimentally establishing the isomorphism with the JC model.

Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats.

PubMed

Dubey, Vivek Kumar; Ansari, Faraha; Vohora, Divya; Khanam, Razia

2015-01-01

In the present study, we investigated the effects of chromium picolinate (CrP) on behavioural and biochemical parameters in chronic unpredictable mild stress (CUMS) induced depression and anxiety in rats. The normal and stressed male Swiss albino rats were administered CrP (8 and 16μg/mL in drinking water), they received stressors for seven days (each day one stressor) and this cycle was repeated three times for 21 days. On 22nd day, behaviour assessments followed by biochemical estimations were conducted. The results showed that treatment of CrP produced significant antidepressant effect, which has been evidenced by decrease in immobility time in modified forced swimming test (FST) in chronic unpredictable mild stress (CUMS) induced depression in rats. In elevated plus maze (EPM), CrP (16μg/mL) showed significant reduction in time spent in open arm. CrP (8μg/mL and 16μg/mL) also showed significant decrease in number of entries in open arm that shows antianxiety effect of CrP in CUMS rats. It was also found that CrP (8 and 16μg/mL) significantly increased 5-HT concentration in the discrete regions of brain (cortex and cerebellum). On the other hand, the plasma corticosterone level was significantly decreased with CrP (16μg/mL). The results suggested that increase in the concentration of 5-HT and decrease in plasma corticosterone levels could be responsible for improvement in symptoms of depression and anxiety in CUMS induced depression and anxiety in rats. Copyright © 2014 Elsevier GmbH. All rights reserved.

Contribution of population growth to per capita income and sectoral output growth in Japan, 1880-1970.

PubMed

Yamaguchi, M; Kennedy, G

1984-09-01

The authors measured the positive and negative contributions of population and labor force growth to the growth of per capita income and sectoral output in Japan in the 1880-1970 period. A 2-sector growth accounting model that treats population and labor growth as separate variables was used. 3 alternative methods were used: the Residual method, the Verdoorn method, and the factor augmenting rate method. The total contribution of population cum labor growth to per capita income growth tended to be negative in the 1880-1930 period and positive in the 1930-40 and 1950-70. Over the 1880-1970 period as a whole, population cum labor growth made a positive contribution to per capita income growth under the Residual method (0.35%/year), the factor augmenting rate method (0.29%/year), and the Verdoorn method (0.01%/year). In addition, population cum labor growth contributed positively to sectoral output growth. The average contribution to agricultural output growth ranged from 1.03% (Verdoorn) - 1.46%/year (factor augmenting rate), while the average contribution to nonagricultural output growth ranged from 1.22% (Verdoorn) - 1.60%/year (Residual). Although these results are dependent on the model used, the fact that all 3 methods yielded consistent results suggests that population cum labor growth did make a positive contribution to per capita income and sectoral output growth in Japan. These findings imply that in economies where the rate of technical change in agricultural and nonagricultural sectors exceeds population growth, policies that reduce agricultural elasticities may be preferable; on the other hand, policies that reduce agricultural elasticities are to be avoided in economies with low rates of technical change. Moreover, in the early stages of economic development, policies that increase agricultural income and price elasticities should be considered.

Brachyceran Diptera (Insecta) in Cretaceous ambers, Part IV, Significant New Orthorrhaphous Taxa.

PubMed

Grimaldi, David A; Arillo, Antonio; Cumming, Jeffrey M; Hauser, Martin

2011-01-01

Thirteen species of basal Brachycera (11 described as new) are reported, belonging to nine families and three infraorders. They are preserved in amber from the Early Cretaceous (Neocomian) of Lebanon, Albian of northern Spain, upper Albian to lower Cenomanian of northern Myanmar, and Late Cretaceous of New Jersey USA (Turonian) and Alberta, Canada (Campanian). Taxa are as follows, with significance as noted: In Stratiomyomorpha: Stratiomyidae (Cretaceogaster pygmaeus Teskey [2 new specimens in Canadian amber], Lysistrata emerita Grimaldi & Arillo, gen. et sp. n. [stem-group species of the family in Spanish amber]), and Xylomyidae (Cretoxyla azari Grimaldi & Cumming, gen. et sp. n. [in Lebanese amber], and an undescribed species from Spain). In Tabanomorpha: Tabanidae (Cratotabanus newjerseyensis Grimaldi, sp. n., in New Jersey amber). In Muscomorpha: Acroceridae (Schlingeromyia minuta Grimaldi & Hauser, gen. et sp. n. and Burmacyrtus rusmithi Grimaldi & Hauser gen. etsp. n., in Burmese amber, the only definitive species of the family from the Cretaceous); Mythicomyiidae (Microburmyia analvena Grimaldi & Cumming gen. et sp. n. and Microburmyia veanalvena Grimaldi & Cumming, sp. n., stem-group species of the family, both in Burmese amber); Apsilocephalidae or near (therevoid family-group) (Kumaromyia burmitica Grimaldi & Hauser, gen. et sp. n. [in Burmese amber]); Apystomyiidae (Hilarimorphites burmanica Grimaldi & Cumming, sp. n. [in Burmese amber], whose closest relatives are from the Late Jurassic of Kazachstan, the Late Cretaceous of New Jersey, and Recent of California). Lastly, two species belonging to families incertae sedis, both in Burmese amber: Tethepomyiidae (Tethepomyia zigrasi Grimaldi & Arillo sp. n., the aculeate oviscapt of which indicates this family was probably parasitoidal and related to Eremochaetidae); and unplaced to family is Myanmyia asteiformia Grimaldi, gen. et sp. n., a minute fly with highly reduced venation. These new taxa significantly expand the Mesozoic fossil record of rare and phylogenetically significant taxa of lower Brachycera.

Exploration of the Tavis-Cummings Model with Multiple Qubits in Circuit QED

NASA Astrophysics Data System (ADS)

Fink, J. M.; Blais, A.; Wallraff, A.

2009-03-01

Superconducting qubits in coplanar waveguide resonators provide an unprecedentedly large dipole coupling strength to microwave frequency photons confined in an on-chip waveguide resonator [1]. In contrast to atoms in traditional cavity QED a controlled number of qubits remain at fixed positions with constant coupling to the cavity field at all times. Utilizing these properties we have performed measurements with up to three independently flux-tunable qubits to study cavity mediated multi-qubit interactions. By tuning the qubits in resonance with the cavity field individually, we demonstrate the square root of N scaling of the collective dipole coupling strength with the number of resonant atoms N as described by the Tavis-Cummings model. To our knowledge this is the first observation of this nonlinearity in a system in which the atom number can be changed one by one in a discrete fashion. In addition, the energies of both bright and dark coupled multi-qubit / photon states are well explained by the Tavis-Cummings model over a wide range of detunings. On resonance we obtain an equal superposition of a photon and a Dicke state with an excitation equally shared among the N qubits.[1] J. M. Fink et al. Nature 454, 315 (2008).

Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: modulation of hypothalamic-pituitary-adrenal axis activity and brain-derived neurotrophic factor level.

PubMed

Jindal, Ankur; Mahesh, Radhakrishnan; Bhatt, Shvetank

2013-11-01

Preliminary study in our laboratory showed that etazolate produced antidepressant- and anxiolytic-like effects in rodent models, however, the ability of etazolate to produce antidepressant- and anxiolytic-like effects and underlying mechanism(s) in chronic unpredictable mild stress (CUMS) model have not been adequately addressed. This study was aimed to investigate the beneficial effects of etazolate on CUMS-induced behavioral deficits (depression- and anxiety-like behaviors). In addition, the possible underlying mechanism(s) of etazolate in CUMS model was also investigated by measuring serum corticosterone (CORT) and brain-derived neurotrophic factor (BDNF) levels. Mice were subjected to a battery of stressors for 28 days. Etazolate (0.5 and 1 mg/kg, p.o.) and fluoxetine (20mg/kg, p.o.) were administered during the last 21 days (8-28th) of the CUMS paradigm. The results showed that 4-weeks CUMS produces significant depression-like behavior in tail suspension test (TST) and partial anxiety-like behavior in elevated plus maze (EPM) and open field test (OFT). Stressed mice have also shown a significant high serum CORT and low BDNF level. Chronic treatment with etazolate (0.5 and 1mg/kg., p.o.) and fluoxetine (20mg/kg., p.o.) produced significant antidepressant-like behavior in TST (decreased duration of immobility), whereas, partial anxiolytic-like behavior in EPM (increased percentage of open arm entries) and OFT (increased % central ambulation score, total ambulation score and time spent in center zone). In addition, etazolate and fluoxetine treatment significantly (p<0.05) increased the BDNF level and inhibited the hypothalamic-pituitary-adrenocortical (HPA) axis hyperactivity, as evidenced by low serum CORT level in stressed mice. In addition, etazolate and fluoxetine also showed significant antidepressant- and anxiolytic-like effects in normal control mice. In this study no significant changes were observed in locomotor activity in actophotometer test. Moreover, we did not find any effect of etazolate and fluoxetine on CORT and BDNF levels in normal control mice. In conclusion, the results of the present study suggested compelling evidences that etazolate has more marked effect on depression-like behavior in mice, which is atleast in part may be related to their modulating effects on the HPA axis and BDNF level. Copyright © 2013 Elsevier Ltd. All rights reserved.

In search of ancient biomarkers: Using femtosecond - Laser Desorption Post Ionization - Mass Spectrometry (fs-LDPI-MS) to map organic compounds within ca. 2.7 Ga samples from the Abitibi greenstone belt, Ontario, Canada

NASA Astrophysics Data System (ADS)

Pasterski, M. J.; Barry, G.; Hanley, L.; Kenig, F. P. H.

2016-12-01

One of the major challenges within the field of organic geochemistry is to determine whether an observed biomarker signature was emplaced during sedimentation (indigenous), after sedimentation via the post-depositional migration of fluids (non-indigenous), or during sampling, storage, or analysis (contaminant). Current geochemical techniques (e.g. gas chromatography-mass spectrometry, GC-MS and GCxGC-MS) can effectively determine the composition and structure of the organic constituents of a sample. However, because of the multiple preparatory steps necessary prior to GC-MS analysis (sample crushing, solvent extraction, organic fraction separation) it is impossible to precisely determine the spatial relationship between the host sample and the organic molecules within. We used an MS imaging method developed by Prof. Luke Hanley at the University of Illinois at Chicago, femtosecond-laser desorption post ionization-MS (fs-LDPI-MS), to map the organics within previously characterized ca.2.7 billion year old (Ga) metasediments from the Abitibi greenstone belt near Timmins, ON, Canada. We then compared the MS images to petrographic observations that displayed the distribution of mineral species with well constrained mineralization ages as well as fluid inclusions within the samples. Fluid inclusions are formed during mineralization and have the ability to remain intact over long timescales (up to billions of years), protecting the fluids inside from the introduction of non-indigenous and contaminant biomarkers. Although migrating post-depositional fluids can remineralize sediments, fluid inclusions associated with secondary additions are focused along grain boundaries and microfractures (secondary inclusions), thus, inclusions which are located within grain boundaries can be considered primary and the age of their formation can be determined relative to the host rock. Preliminary results indicate that previously observed biomarkers may be linked to a series of hydrothermal events which occurred regionally ca. 2.64 Ga.

Sulfur isotope and trace element data from ore sulfides in the Noranda district (Abitibi, Canada): implications for volcanogenic massive sulfide deposit genesis

NASA Astrophysics Data System (ADS)

Sharman, Elizabeth R.; Taylor, Bruce E.; Minarik, William G.; Dubé, Benoît; Wing, Boswell A.

2015-06-01

We examine models for volcanogenic massive sulfide (VMS) mineralization in the ~2.7-Ga Noranda camp, Abitibi subprovince, Superior Province, Canada, using a combination of multiple sulfur isotope and trace element data from ore sulfide minerals. The Noranda camp is a well-preserved, VMS deposit-rich area that is thought to represent a collapsed volcanic caldera. Due to its economic value, the camp has been studied extensively, providing a robust geological framework within which to assess the new data presented in this study. We explore previously proposed controls on mineralization within the Noranda camp and, in particular, the exceptional Au-rich Horne and Quemont deposits. We present multiple sulfur isotope and trace element compositional data for sulfide separates representing 25 different VMS deposits and "showings" within the Noranda camp. Multiple sulfur isotope data for this study have δ34SV-CDT values of between -1.9 and +2.5 ‰, and Δ33SV-CDT values of between -0.59 and -0.03 ‰. We interpret the negative Δ33S values to be due to a contribution of sulfur that originated as seawater sulfate to form the ore sulfides of the Noranda camp VMS deposits. The contribution of seawater sulfate increased with the collapse and subsequent evolution of the Noranda caldera, an inference supported by select trace and major element analyses. In particular, higher concentrations of Se occur in samples with Δ33S values closer to 0 ‰, as well as lower Fe/Zn ratios in sphalerite, suggesting lower pressures and temperatures of formation. We also report a relationship between average Au grade and Δ33S values within Au-rich VMS deposits of the Noranda camp, whereby higher gold grades are associated with near-zero Δ33S values. From this, we infer a dominance of igneous sulfur in the gold-rich deposits, either leached from the volcanic pile and/or directly degassed from an associated intrusion.

Finite-β Split-weight Gyrokinetic Particle Simulation of Microinstabilities

NASA Astrophysics Data System (ADS)

Jenkins, Thomas G.; Lee, W. W.; Lewandowski, J. L. V.

2003-10-01

The finite-β split-weight gyrokinetic particle simulation scheme [1] has been implemented in two-dimensional slab geometry for the purpose of studying the effects of high temperature electrons on microinstabilities. Drift wave instabilities and ion temperature gradient modes are studied in both shearless slab and sheared slab geometries. The linear and nonlinear evolution of these modes, as well as the physics of microtearing, is compared with the results of Reynders [2] and Cummings [3]. [1] W. W. Lee, J. L. V. Lewandowski, T. S. Hahm, and Z. Lin, Phys. Plasmas 8, 4435 (2001). [2] J. V. W. Reynders, Ph.D. thesis, Princeton University (1992). [3] J. C. Cummings, Ph.D. thesis, Princeton University (1995).

[Correlation research of photosynthetic characteristics and medicinal materials production with 4 Uncariae Cum Uncis].

PubMed

Luo, Min; Song, Zhi-Qin; Yang, Ping-Fei; Liu, Hai; Yang, Zai-Gang; Wu, Ming-Kai

2017-01-01

Using four Uncariae Cum Uncis materials including Uncaria sinensis (HGT), U. hirsutea (MGT), Jianhe U. rhynchophylla (JHGT) and U. rhynchophylla(GT) as the research objects, the correlations between medicinal materials' yield and photosynthetic ecophysiology-factors in the plant exuberant growth period were studied. Results showed that the Uncaria plants net photosynthetic rate (Pn) changed by unimodal curve. There was not "midday depression" phenomenon. There was a different relationship among the photosynthetic ecophysiology-factors and between photosynthetic ecophysiology-factors and medicinal materials' yield. Pn,Tl,Gs had a significant correlation with medicinal materials' yield（M）and were the most important factors of growth. Copyright© by the Chinese Pharmaceutical Association.

Major and Trace Element Geochemistry and Os Isotopic Compositions of Komatiites From Dundonald Beach, Abitibi Greenstone Belt, Canada

NASA Astrophysics Data System (ADS)

Gangopadhyay, A.; Walker, R. J.; Sproule, R. A.; Lesher, C.

2003-12-01

We have examined the major and trace elements, and Os isotopic compositions of a suite of cumulate and spinifex textured komatiitic rocks from the Dundonald Beach area, part of the ˜2.7 Ga Abitibi greenstone Belt, Ontario, Canada. This suite of rocks forms a series from peridotitic komatiites (MgO ˜ 42 wt.% on a volatile-free basis) to komatiitic basalts (MgO ˜8 wt.%). Based on major element oxide ratios (e.g. Al2O3/TiO2 ˜21-26 and CaO/Al2O3 typically <= 1) and unfractionated HREE characteristics (e.g. (Gd/Yb)N ˜0.9-1.1), these rocks are similar to the spatially associated Al-undepleted komatiites from Alexo and Munro Townships. Also, these rocks are strongly LREE-depleted ((La/Sm)N = 0.41-0.67; (Ce/Yb)N = 0.41-0.70)) and have variable total REE (4-22 ppm). A strong negative correlation between Mg# and total REEs suggests that the REE patterns of these rocks are primary features of their mantle source. The Re-Os isotope results for whole-rock komatiites and chromite separates from a single flow yield a model 3 isochron age of 2606 +/- 55 Ma. This age is slightly younger ( ˜50 Ma) compared to the U-Pb zircon ages of the associated volcanics reported from the presumed extension of the same Kidd-Munro assemblage in Alexo and Munro Townships. The initial 187Os/188Os ratio (0.1090 +/- 0.0019) obtained from the regression is essentially chondritic (γ Os(T) = -0.2 +/- 1.7). The peridotitic komatiites have the highest Os concentrations and low 187Re/188Os ratios (up to ˜4.2 ppb and < 0.5, respectively) among the whole rocks, whereas the komatiitic basalts have relatively low Os concentrations ( ˜0.3 ppb) and high 187Re/188Os ratios ( ˜3.1-11.9). For these komatiites, Os was compatible with the mantle residue (DOsmantle-melt ˜7.6), whereas Re was moderately incompatible (DRe ˜0.6), typical of most komatiitic magmas. The absence of a strong correlation between Os and Ni concentrations in the whole-rocks suggests that the distribution of Os in these rocks is not primarily controlled by fractionation of olivine. The apparent DReol+chmt/liq. ( ˜0.7), on the other hand, suggests that Re was moderately incompatible in olivine and/or chromite during the differentiation of komatiitic magmas. A chondritic initial Os isotopic composition for the mantle source for these komatiites is consistent with that previously reported for the komatiites from Alexo and Munro Townships. Our Os isotopic results for Dundonald komatiites, combined with those reported for Alexo and Pyke Hill komatiites, therefore, suggest that a major portion of the ˜2.7 Ga mantle source for the komatiites in the Abitibi greenstone belt was dominated by Os with chondritic isotopic compositions. Also, the LREE-depleted, yet chondritic Os isotopic composition for the mantle source of these komatiites is indistinguishable from the projected chondritic composition of the contemporaneous depleted convective upper mantle.

Design and Development of Maize Dehusker cum Sheller: A Technology for Northern Transition Zone of Karnataka, India

NASA Astrophysics Data System (ADS)

Chilur, Rudragouda; Kumar, Sushilendra

2018-06-01

The Maize ( Zea mays L.) crop is one of the most important cereal in agricultural production systems of Northern Transition Zone (Hyderabad-Karnataka region) in India. These Hyderabad Karnataka farmers (small-medium) are lack of economic technologies with maize dehusking and shelling, which fulfils the two major needs as crops and as livestock in farming. The portable medium size (600 kg/h capacity) electric motor (2.23 kW) operated Maize Dehusker cum Sheller (MDS) was designed to resolve the issue by considering engineering properties of maize. The developed trapezium shaped MDS machine having overall dimensions (length × (top and bottom) × height) of 1200 × (500 and 610) × 810 mm. The selected operational parameters viz, cylinder peripheral speed (7.1 m/s), concave clearance (25 mm) and feed rate (600 kg/h) were studied for machine-performance and seed-quality parameters. The performance of machine under these parameters showed the dehusking efficiency of 99.56%, shelling efficiency of 98.01%, cleaning efficiency of 99.11%, total loss of 3.63% machine capacity of 527.11 kg/kW-h and germination percentage of 98.93%. Overall machine performance was found satisfactory for maize dehusking cum shelling operation as well as to produce the maize grains for seeding purpose.

Design and Development of Maize Dehusker cum Sheller: A Technology for Northern Transition Zone of Karnataka, India

NASA Astrophysics Data System (ADS)

Chilur, Rudragouda; Kumar, Sushilendra

2018-02-01

The Maize (Zea mays L.) crop is one of the most important cereal in agricultural production systems of Northern Transition Zone (Hyderabad-Karnataka region) in India. These Hyderabad Karnataka farmers (small-medium) are lack of economic technologies with maize dehusking and shelling, which fulfils the two major needs as crops and as livestock in farming. The portable medium size (600 kg/h capacity) electric motor (2.23 kW) operated Maize Dehusker cum Sheller (MDS) was designed to resolve the issue by considering engineering properties of maize. The developed trapezium shaped MDS machine having overall dimensions (length × (top and bottom) × height) of 1200 × (500 and 610) × 810 mm. The selected operational parameters viz, cylinder peripheral speed (7.1 m/s), concave clearance (25 mm) and feed rate (600 kg/h) were studied for machine-performance and seed-quality parameters. The performance of machine under these parameters showed the dehusking efficiency of 99.56%, shelling efficiency of 98.01%, cleaning efficiency of 99.11%, total loss of 3.63% machine capacity of 527.11 kg/kW-h and germination percentage of 98.93%. Overall machine performance was found satisfactory for maize dehusking cum shelling operation as well as to produce the maize grains for seeding purpose.

The Effects of High-fat-diet Combined with Chronic Unpredictable Mild Stress on Depression-like Behavior and Leptin/LepRb in Male Rats.

PubMed

Yang, Jin Ling; Liu, De Xiang; Jiang, Hong; Pan, Fang; Ho, Cyrus Sh; Ho, Roger Cm

2016-10-14

Leptin plays a key role in the pathogenesis of obesity and depression via the long form of leptin receptor (LepRb). An animal model of comorbid obesity and depression induced by high-fat diet (HFD) combined with chronic unpredictable mild stress (CUMS) was developed to study the relationship between depression/anxiety-like behavior, levels of plasma leptin and LepRb in the brains between four groups of rats, the combined obesity and CUMS (Co) group, the obese (Ob) group, the CUMS group and controls. Our results revealed that the Co group exhibited most severe depression-like behavior in the open field test (OFT), anxiety-like behavior in elevated plus maze test (EMT) and cognitive impairment in the Morris water maze (MWM). The Ob group had the highest weight and plasma leptin levels while the Co group had the lowest levels of protein of LepRb in the hypothalamus and hippocampus. Furthermore, depressive and anxiety-like behaviors as well as cognitive impairment were positively correlated with levels of LepRb protein and mRNA in the hippocampus and hypothalamus. The down-regulation of leptin/LepRb signaling might be associated with depressive-like behavior and cognitive impairment in obese rats facing chronic mild stress.

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress.

PubMed

Liu, Ya-Min; Shen, Ji-Duo; Xu, Li-Ping; Li, Han-Bing; Li, Yu-Cheng; Yi, Li-Tao

2017-04-01

Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components. It has been demonstrated that ferulic acid can attenuate depressive-like behaviors in both forced swimming test and tail suspension test. Considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mice exposed to chronic unpredictable mild stress (CUMS). Our results firstly showed that decreased sucrose preference and increased immobility time were completely reversed by administration with ferulic acid and fluoxetine for four weeks. Then, we found that CUMS significantly caused interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) up-regulation, microglia, NF-κB signaling and NLRP3 inflammasome activation in the prefrontal cortex. On the contrary, these activated inflammatory response induced by CUMS were reversed by ferulic acid and fluoxetine as well, suggesting that anti-inflammatory related mechanism was involved in the antidepressant-like effects of ferulic acid in stressed mice. Copyright © 2017 Elsevier B.V. All rights reserved.

Perfectionism, Burnout, and Motivation in Dance: A Replication and Test of the 2×2 Model of Perfectionism.

PubMed

Nordin-Bates, Sanna M; Raedeke, Thomas D; Madigan, Daniel J

2017-09-15

The relationships between multidimensional perfectionism, burnout, and motivation were examined. In so doing, this study aimed to replicate and extend the study by Cumming and Duda (2012). Ninety-one ballet dancers completed questionnaires assessing the target constructs. Using cluster analysis, four profiles emerged that replicated Cumming and Duda's findings and generally supported Gaudrau and Thompson's 2x2 model of perfectionism. As such, these profiles represented pure personal standards perfectionism, mixed perfectionism, pure evaluative concerns perfectionism, and non-perfectionism. Extending previous literature, the four profiles were then compared on a range of burnout symptoms and motivational regulations. It was found that the four clusters differed significantly on these constructs, in a manner partly supportive of the hypotheses associated with the 2x2 model of perfectionism. In particular, our results reflect and extend those of Cumming and Duda, in that mixed perfectionism and pure evaluative concerns perfectionism did not differ on any of the measures. Thus, the higher personal standards of dancers exhibiting mixed perfectionism did not appear to be associated with better functioning than that experienced by dancers with pure evaluative concerns perfectionism. Altogether, the study extends our current understanding of perfectionism in dance and its potential effects, including those on burnout and motivation.

Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice.

PubMed

Thakare, Vishnu N; Patil, Rajesh R; Oswal, Rajesh J; Dhakane, Valmik D; Aswar, Manoj K; Patel, Bhoomika M

2018-02-01

Silymarin, a plant-derived polyphenolic flavonoid of Silybum marianum, elicited significant antidepressant-like activity in an acute restraint stress model of depression. It improved monoamines, mainly 5-hydroxytryptamine (5-HT) levels in the cortex, dopamine (DA) and norepinephrine (NE) in the cerebellum in mice. The present study was undertaken to explore the antidepressant potential of silymarin in chronic unpredictable mild stress (CUMS) induced depressive-like behavior in mice, and to find out its probable mechanism(s) of action, mainly neurogenesis, neuroinflammation, and/or oxidative stress. The mice were subjected to CUMS for 28 days (4 weeks) and administered with silymarin (100 mg/kg and 200 mg/kg), or fluoxetine or vehicle from days 8 to 28 (3 weeks simultaneously). Animals were evaluated for behavioral changes, such as anhedonia by sucrose preference test, behavioral despair by forced swim test, and exploratory behaviors by an open field test. In addition, neurobiochemical alterations, mainly monoamines, 5-HT, NE, DA, neurotrophic factor BDNF, and cytokines, IL-6, TNF-α, oxidant-antioxidant parameters by determining the malondialdehyde formation (an index of lipid peroxidation process), superoxide dismutase (SOD) and catalase (CAT) activity in hippocampus and cerebral cortex along with serum corticosterone were investigated. Our findings reveal that mice subjected to CUMS exhibited lower sucrose preference, increase immobility time without affecting general locomotion of the animals, and reduce BDNF, 5-HT, NE, and DA level, increased serum corticosterone, IL-6 and TNF-α along with an oxidant-antioxidant imbalance in the hippocampus and cerebral cortex. Silymarin significantly reversed the CUMS-induced changes in the hippocampus and cerebral cortex in mice. Thus, the possible mechanism involved in the antidepressant-like activity of silymarin is correlated to the alleviation of monoaminergic, neurogenesis (enhancing 5-HT, NE, and BDNF levels), and attenuation of inflammatory cytokines system and oxidative stress by modulation of corticosterone response, restoration of antioxidant defense system in cerebral cortex and hippocampus.

Brachyceran Diptera (Insecta) in Cretaceous ambers, Part IV, Significant New Orthorrhaphous Taxa

PubMed Central

Grimaldi, David A.; Arillo, Antonio; Cumming, Jeffrey M.; Hauser, Martin

2011-01-01

Abstract Thirteen species of basal Brachycera (11 described as new) are reported, belonging to nine families and three infraorders. They are preserved in amber from the Early Cretaceous (Neocomian) of Lebanon, Albian of northern Spain, upper Albian to lower Cenomanian of northern Myanmar, and Late Cretaceous of New Jersey USA (Turonian) and Alberta, Canada (Campanian). Taxa are as follows, with significance as noted: In Stratiomyomorpha: Stratiomyidae (Cretaceogaster pygmaeus Teskey [2 new specimens in Canadian amber], Lysistrata emerita Grimaldi & Arillo, gen. et sp. n. [stem-group species of the family in Spanish amber]), and Xylomyidae (Cretoxyla azari Grimaldi & Cumming, gen. et sp. n. [in Lebanese amber], and an undescribed species from Spain). In Tabanomorpha: Tabanidae (Cratotabanus newjerseyensis Grimaldi, sp. n., in New Jersey amber). In Muscomorpha: Acroceridae (Schlingeromyia minuta Grimaldi & Hauser, gen. et sp. n. and Burmacyrtus rusmithi Grimaldi & Hauser gen. et sp. n., in Burmese amber, the only definitive species of the family from the Cretaceous); Mythicomyiidae (Microburmyia analvena Grimaldi & Cumming gen. et sp. n. and Microburmyia veanalvena Grimaldi & Cumming, sp. n., stem-group species of the family, both in Burmese amber); Apsilocephalidae or near (therevoid family-group) (Kumaromyia burmitica Grimaldi & Hauser, gen. et sp. n. [in Burmese amber]); Apystomyiidae (Hilarimorphites burmanica Grimaldi & Cumming, sp. n. [in Burmese amber], whose closest relatives are from the Late Jurassic of Kazachstan, the Late Cretaceous of New Jersey, and Recent of California). Lastly, two species belonging to families incertae sedis, both in Burmese amber: Tethepomyiidae (Tethepomyia zigrasi Grimaldi & Arillo sp. n., the aculeate oviscapt of which indicates this family was probably parasitoidal and related to Eremochaetidae); and unplaced to family is Myanmyia asteiformia Grimaldi, gen. et sp. n., a minute fly with highly reduced venation. These new taxa significantly expand the Mesozoic fossil record of rare and phylogenetically significant taxa of lower Brachycera. PMID:22287902

On the relationship between the classical Dicke-Jaynes-Cummings-Gaudin model and the nonlinear Schroedinger equation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Du, Dianlou; Geng, Xue

2013-05-15

In this paper, the relationship between the classical Dicke-Jaynes-Cummings-Gaudin (DJCG) model and the nonlinear Schroedinger (NLS) equation is studied. It is shown that the classical DJCG model is equivalent to a stationary NLS equation. Moreover, the standard NLS equation can be solved by the classical DJCG model and a suitably chosen higher order flow. Further, it is also shown that classical DJCG model can be transformed into the classical Gaudin spin model in an external magnetic field through a deformation of Lax matrix. Finally, the separated variables are constructed on the common level sets of Casimir functions and the generalizedmore » action-angle coordinates are introduced via the Hamilton-Jacobi equation.« less

Effect of atomic spontaneous decay on entanglement in the generalized Jaynes-Cummings model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hessian, H.A.; Obada, A.-S.F.; Mohamed, A.-B.A.

2010-03-15

Some aspects of the irreversible dynamics of a generalized Jaynes-Cummings model are addressed. By working in the dressed-state representation, it is possible to split the dynamics of the entanglement and coherence. The exact solution of the master equation in the case of a high-Q cavity with atomic decay is found. Effects of the atomic spontaneous decay on the temporal evolution of partial entropies of the atom or the field and the total entropy as a quantitative measure entanglement are elucidated. The degree of entanglement, through the sum of the negative eigenvalues of the partially transposed density matrix and the negativemore » mutual information has been studied and compared with other measures.« less

Deep Strong Coupling Regime of the Jaynes-Cummings Model

NASA Astrophysics Data System (ADS)

Casanova, J.; Romero, G.; Lizuain, I.; García-Ripoll, J. J.; Solano, E.

2010-12-01

We study the quantum dynamics of a two-level system interacting with a quantized harmonic oscillator in the deep strong coupling regime (DSC) of the Jaynes-Cummings model, that is, when the coupling strength g is comparable or larger than the oscillator frequency ω (g/ω≳1). In this case, the rotating-wave approximation cannot be applied or treated perturbatively in general. We propose an intuitive and predictive physical frame to describe the DSC regime where photon number wave packets bounce back and forth along parity chains of the Hilbert space, while producing collapse and revivals of the initial population. We exemplify our physical frame with numerical and analytical considerations in the qubit population, photon statistics, and Wigner phase space.

Metabolomic Profiling of Post-Mortem Brain Reveals Changes in Amino Acid and Glucose Metabolism in Mental Illness Compared with Controls.

PubMed

Zhang, Rong; Zhang, Tong; Ali, Ali Muhsen; Al Washih, Mohammed; Pickard, Benjamin; Watson, David G

2016-01-01

Metabolomic profiling was carried out on 53 post-mortem brain samples from subjects diagnosed with schizophrenia, depression, bipolar disorder (SDB), diabetes, and controls. Chromatography on a ZICpHILIC column was used with detection by Orbitrap mass spectrometry. Data extraction was carried out with m/z Mine 2.14 with metabolite searching against an in-house database. There was no clear discrimination between the controls and the SDB samples on the basis of a principal components analysis (PCA) model of 755 identified or putatively identified metabolites. Orthogonal partial least square discriminant analysis (OPLSDA) produced clear separation between 17 of the controls and 19 of the SDB samples (R2CUM 0.976, Q2 0.671, p-value of the cross-validated ANOVA score 0.0024). The most important metabolites producing discrimination were the lipophilic amino acids leucine/isoleucine, proline, methionine, phenylalanine, and tyrosine; the neurotransmitters GABA and NAAG and sugar metabolites sorbitol, gluconic acid, xylitol, ribitol, arabinotol, and erythritol. Eight samples from diabetic brains were analysed, six of which grouped with the SDB samples without compromising the model (R2 CUM 0.850, Q2 CUM 0.534, p-value for cross-validated ANOVA score 0.00087). There appears on the basis of this small sample set to be some commonality between metabolic perturbations resulting from diabetes and from SDB.

Coupled ultrasonication-milling synthesis of hierarchically porous carbon for high-performance supercapacitor.

PubMed

Yang, Dewei; Jing, Huijuan; Wang, Zhaowu; Li, Jiaheng; Hu, Mingxiang; Lv, Ruitao; Zhang, Rui; Chen, Deliang

2018-05-19

Activated carbon (AC) based supercapacitors exhibit intrinsic advantages in energy storage. Traditional two-step synthesis (carbonization and activation) of AC faces difficulties in precisely regulating its pore-size distribution and thoroughly removing residual impurities like silicon oxide. This paper reports a novel coupled ultrasonication-milling (CUM) process for the preparation of hierarchically porous carbon (HPC) using corn cobs as the carbon resource. The as-obtained HPC is of a large surface area (2288 m 2  g -1 ) with a high mesopore ratio of ∼44.6%. When tested in a three-electrode system, the HPC exhibits a high specific capacitance of 465 F g -1 at 0.5 Ag -1 , 2.7 times higher than that (170 F g -1 ) of the commercial AC (YP-50F). In the two-electrode test system, the HPC device exhibits a specific capacitance of 135 F g -1 at 1 A g -1 , twice higher than that (68 F g -1 ) of YP-50F. The above excellent energy-storage properties are resulted from the CUM process which efficiently removes the impurities and modulates the mesopore/micropore structures of the AC samples derived from the agricultural resides of corn cobs. The CUM process is an efficient method to prepare high-performance biomass-derived AC materials. Copyright © 2018 Elsevier Inc. All rights reserved.

Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice.

PubMed

Taksande, Brijesh G; Faldu, Dharmesh S; Dixit, Madhura P; Sakaria, Jay N; Aglawe, Manish M; Umekar, Milind J; Kotagale, Nandkishor R

2013-11-15

Chronic stress exposure and resulting dysregulation of the hypothalamic pituitary adrenal axis develops susceptibility to variety of neurological and psychiatric disorders. Agmatine, a putative neurotransmitter has been reported to be released in response to various stressful stimuli to maintain the homeostasis. Present study investigated the role of agmatine on chronic unpredictable mild stress (CUMS) induced behavioral and biochemical alteration in mice. Exposure of mice to CUMS protocol for 28 days resulted in diminished performance in sucrose preference test, splash test, forced swim test and marked elevation in plasma corticosterone levels. Chronic agmatine (5 and 10 mg/kg, ip, once daily) treatment started on day-15 and continued till the end of the CUMS protocol significantly increased sucrose preference, improved self-care and motivational behavior in the splash test and decreased duration of immobility in the forced swim test. Agmatine treatment also normalized the elevated corticosterone levels and prevented the body weight changes in chronically stressed animals. The pharmacological effect of agmatine was comparable to selective serotonin reuptake inhibitor, fluoxetine (10mg/kg, ip). Results of present study clearly demonstrated the anti-depressant like effect of agmatine in chronic unpredictable mild stress induced depression in mice. Thus the development of drugs based on brain agmatinergic modulation may represent a new potential approach for the treatment of stress related mood disorders like depression. © 2013 Published by Elsevier B.V.

Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice.

PubMed

Liu, Ya-Min; Niu, Le; Wang, Lin-Lin; Bai, Li; Fang, Xiao-Yan; Li, Yu-Cheng; Yi, Li-Tao

2017-09-01

Berberine, the major constituent alkaloid originally from the famous Chinese herb Huanglian (Coptis chinensis), has been shown to exert antidepressant-like effects in rodents. However, it is still not clear the involvement of neuro-inflammation suppression in the effects of berberine. The purpose of this study was to determine whether berberine affects the neuro-inflammation system in mice induced by chronic unpredictable mild stress (CUMS). Berberine was orally administrated in normal or CUMS mice for successive four weeks. Behavioral evaluation showed that berberine prevented the depressive deficits both in sucrose preference test and novelty-suppressed feeding test. The elevation of hippocampal pro-inflammatory cytokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), as well as the activation of microglia were decreased by berberine. In addition, chronic berberine treatment inhibited nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway as the phosphorylated proteins of NF-κB, IκB kinase (IKK)α and IKKβ in the hippocampus were suppressed after berberine administration. Furthermore, inducible nitric oxide synthase (iNOS), one downstream target of NF-κB signaling pathway was also inhibited by berberine. In conclusion, these findings suggest that administration of berberine could prevent depressive-like behaviors in CUMS mice by suppressing neuro-inflammation in the hippocampus. Copyright © 2017 Elsevier Inc. All rights reserved.

Time-dependent nonlinear Jaynes-Cummings dynamics of a trapped ion

NASA Astrophysics Data System (ADS)

Krumm, F.; Vogel, W.

2018-04-01

In quantum interaction problems with explicitly time-dependent interaction Hamiltonians, the time ordering plays a crucial role for describing the quantum evolution of the system under consideration. In such complex scenarios, exact solutions of the dynamics are rarely available. Here we study the nonlinear vibronic dynamics of a trapped ion, driven in the resolved sideband regime with some small frequency mismatch. By describing the pump field in a quantized manner, we are able to derive exact solutions for the dynamics of the system. This eventually allows us to provide analytical solutions for various types of time-dependent quantities. In particular, we study in some detail the electronic and the motional quantum dynamics of the ion, as well as the time evolution of the nonclassicality of the motional quantum state.

Facial trauma

MedlinePlus

... the face include: Car and motorcycle crashes Wounds Sports injuries Violence Symptoms Symptoms may include: Changes in ... Maxillofacial trauma. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head and Neck ...

Perichondritis

MedlinePlus

... Ear piercing (especially piercing of the cartilage) Contact sports Trauma to the side of the head Ear ... external ear. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology . 6th ed. Philadelphia, ...

Importance of counter-rotating coupling in the superfluid-to-Mott-insulator quantum phase transition of light in the Jaynes-Cummings lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng Hang; Takada, Yasutami

2011-10-15

The quantum phase transition between Mott insulator and superfluid is studied in the two-dimensional Jaynes-Cummings square lattice in which the counter-rotating coupling (CRC) is included. Both the ground state and the spectra of low-lying excitations are obtained with use of a sophisticated unitary transformation. This CRC is shown not only to induce a long-range interaction between cavities, favoring the long-range superfluid order, but also to break the conservation of local polariton number at each site, leading to the absence of the Mott lobes in the phase diagram, in sharp contrast with the case without the CRC as well as thatmore » of the Bose-Hubbard model.« less

The Nonlinear Jaynes-Cummings Model for the Multiphoton Transition

NASA Astrophysics Data System (ADS)

Liu, Xiao-Jing; Lu, Jing-Bin; Zhang, Si-Qi; Liu, Ji-Ping; Li, Hong; Liang, Yu; Ma, Ji; Weng, Yi-Jiao; Zhang, Qi-Rui; Liu, Han; Zhang, Xiao-Ru; Wu, Xiang-Yao

2018-01-01

With the nonlinear Jaynes-Cummings model, we have studied the atom and light field quantum entanglement of multiphoton transition in nonlinear medium, and researched the effect of the transition photon number N and the nonlinear coefficient χ on the quantum entanglement degrees. We have given the quantum entanglement degrees curves with time evolution, we find when the transition photon number N increases, the entanglement degrees oscillation get faster. When the nonlinear coefficient α > 0, the entanglement degrees oscillation get quickly, the nonlinear term is disadvantage of the atom and light field entanglement, and when the nonlinear coefficient α < 0, the entanglement degrees oscillation get slow, the nonlinear term is advantage of the atom and light field entanglement. These results will have been used in the quantum communication and quantum information.

Isolation and identification of flavonoids, including flavone rotamers, from the herbal drug 'Crataegi folium cum flore' (hawthorn).

PubMed

Rayyan, S; Fossen, T; Solheim Nateland, H; Andersen, O M

2005-01-01

Twelve flavonoids, including seven flavones, four flavonols and one flavanone, were isolated from methanolic extract of the herbal drug 'Crataegi folium cum flore' (hawthorn leaves and flowers) by a combination of CC (over Amberlite XAD-7 and Sephadex LH-20) and preparative HPLC. Their structures, including that of the novel flavonol 8-methoxykaempferol 3-O-(6"-malonyl-beta-glucopyranoside), were elucidated by homo- and heteronuclear NMR and electrospray/MS. The 1H- and 13C-NMR of all compounds, including rotameric pairs of five flavone C-glycosides, were assigned. The presence and relative proportion of each rotamer was shown by various NMR experiments, including two-dimensional nuclear Overhauser and exchange spectroscopy, to depend on solvent, linkage position and structure of the C-glycosyl substituent.

Mastoidectomy

MedlinePlus

... to treat: Cholesteatoma Complications of an ear infection ( otitis media ) Infections of the mastoid bone that do ... Chole RA. Chronic otitis media, mastoiditis, and petrositis. In: ... V, et al, eds. Cummings Otolaryngology . 6th ed. Philadelphia, ...

Epstein pearls

MedlinePlus

... tumors. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 90. Martin B, Baumhardt H, D'Alesio A, Nazif MM, ...

Monitoring endemic livestock diseases using laboratory diagnostic data: A simulation study to evaluate the performance of univariate process monitoring control algorithms.

PubMed

Lopes Antunes, Ana Carolina; Dórea, Fernanda; Halasa, Tariq; Toft, Nils

2016-05-01

Surveillance systems are critical for accurate, timely monitoring and effective disease control. In this study, we investigated the performance of univariate process monitoring control algorithms in detecting changes in seroprevalence for endemic diseases. We also assessed the effect of sample size (number of sentinel herds tested in the surveillance system) on the performance of the algorithms. Three univariate process monitoring control algorithms were compared: Shewart p Chart(1) (PSHEW), Cumulative Sum(2) (CUSUM) and Exponentially Weighted Moving Average(3) (EWMA). Increases in seroprevalence were simulated from 0.10 to 0.15 and 0.20 over 4, 8, 24, 52 and 104 weeks. Each epidemic scenario was run with 2000 iterations. The cumulative sensitivity(4) (CumSe) and timeliness were used to evaluate the algorithms' performance with a 1% false alarm rate. Using these performance evaluation criteria, it was possible to assess the accuracy and timeliness of the surveillance system working in real-time. The results showed that EWMA and PSHEW had higher CumSe (when compared with the CUSUM) from week 1 until the end of the period for all simulated scenarios. Changes in seroprevalence from 0.10 to 0.20 were more easily detected (higher CumSe) than changes from 0.10 to 0.15 for all three algorithms. Similar results were found with EWMA and PSHEW, based on the median time to detection. Changes in the seroprevalence were detected later with CUSUM, compared to EWMA and PSHEW for the different scenarios. Increasing the sample size 10 fold halved the time to detection (CumSe=1), whereas increasing the sample size 100 fold reduced the time to detection by a factor of 6. This study investigated the performance of three univariate process monitoring control algorithms in monitoring endemic diseases. It was shown that automated systems based on these detection methods identified changes in seroprevalence at different times. Increasing the number of tested herds would lead to faster detection. However, the practical implications of increasing the sample size (such as the costs associated with the disease) should also be taken into account. Copyright © 2016 Elsevier B.V. All rights reserved.

Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice.

PubMed

Ji, Wei-Wei; Li, Rui-Peng; Li, Meng; Wang, Shu-Yuan; Zhang, Xian; Niu, Xing-Xing; Li, Wei; Yan, Lu; Wang, Yang; Fu, Qiang; Ma, Shi-Ping

2014-10-01

Perilla frutescens (Perilla leaf), a garnishing vegetable in East Asian countries, as well as a plant-based medicine, has been used for centuries to treat various conditions, including depression. Several studies have demonstrated that the essential oil of P. frutescens (EOPF) attenuated the depressive-like behavior in mice. The present study was designed to test the anti-depressant effects of EOPF and the possible mechanisms in an chronic, unpredictable, mild stress (CUMS)-induced mouse model. With the exposure to stressor once daily for five consecutive weeks, EOPF (3, 6, and 9 mg·kg(-1)) and a positive control drug fluoxetine (20 mg·kg(-1)) were administered through gastric intubation to mice once daily for three consecutive weeks from the 3(rd) week. Open-field test, sucrose consumption test, tail suspension test (TST), and forced swimming test (FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in mouse hippocampus were determined by HPLC-ECD. Serum interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α levels were evaluated by enzyme-linked immunosorbent assay (ELISA). The results showed that CUMS significantly decreased the levels of 5-HT and 5-HIAA in the hippocampus, with an increase in plasma IL-6, IL-1β, and TNF-α levels. CUMS also reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. EOPF administration could effectively reverse the alterations in the concentrations of 5-HT and 5-HIAA; reduce the IL-6, IL-1β, and TNF-α levels. Moreover, EOPF could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. However, the effect was not dose-dependent. In conclusion, EOPF administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression. The antidepressant activity of EOPF might be related to the relation between alteration of serotonergic responses and anti-inflammatory effects. Copyright © 2014 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/β-catenin pathway in rats.

PubMed

Yang, Xin-Hua; Song, Su-Qi; Xu, Yun

2017-01-01

Classic antidepressant drugs are modestly effective across the population and most are associated with intolerable side effects. Recently, numerous lines of evidence suggest that resveratrol (RES), a natural polyphenol, possesses beneficial therapeutic activity for depression. The aim of the present study was to explore whether RES exhibits an antidepressant-like effect in a depression model and to explore the possible mechanism. A depression model was established via chronic unpredictable mild stress (CUMS), after which the model rats in the RES and fluoxetine groups received a daily injection of RES or fluoxetine, respectively. The sucrose preference test, open field test, and forced swimming test were used to explore the antidepressant-like effects of RES. The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the plasma corticosterone concentration and hypothalamic mRNA expression of corticotrophin-releasing hormone. The plasma interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) concentrations were measured by enzyme-linked immunosorbent assay. Hippocampal protein expression of brain-derived neurotrophic factor (BDNF) and the Wnt/β-catenin pathway were analyzed by western blot. The results showed that RES relieved depression-like behavior of CUMS rats, as indicated by the increased sucrose preference and the decreased immobile time. Rats that received RES treatment exhibited reduced plasma corticosterone levels and corticotrophin-releasing hormone mRNA expression in the hypothalamus, suggesting that the hyperactivity of the HPA axis in CUMS rats was reversed by RES. Moreover, after RES treatment, the rats exhibited increased plasma IL-6, CRP, and TNF-α concentrations. Furthermore, RES treatment upregulated the hippocampal protein levels of BDNF and the relative ratio of p-β-catenin/β-catenin while downregulating the relative ratio of p-GSK-3β/GSK-3β. Our findings suggest that RES improved depressive behavior in CUMS rats by downregulating HPA axis hyperactivity, increasing BDNF expression and plasma IL-6, CRP, and TNF-α concentrations, and regulating the hippocampal Wnt/β-catenin pathway.

Epley maneuver

MedlinePlus

... Clinical practice guideline: benign paroxysmal positional vertigo. Otolaryngol: Head Neck Surg . 2008;139(5 Suppl 4):S47-S81. ... BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: ...

Salivary gland tumors

MedlinePlus

... BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015: ... PDQ) - health professional version. www.cancer.gov/types/head-and-neck/hp/adult/salivary-gland-treatment-pdq . Updated January ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ying-Jie, E-mail: yingjiezhang@qfnu.edu.cn; Han, Wei; Xia, Yun-Jie, E-mail: yjxia@qfnu.edu.cn

We propose a scheme of controlling entanglement dynamics of a quantum system by applying the external classical driving field for two atoms separately located in a single-mode photon cavity. It is shown that, with a judicious choice of the classical-driving strength and the atom–photon detuning, the effective atom–photon interaction Hamiltonian can be switched from Jaynes–Cummings model to anti-Jaynes–Cummings model. By tuning the controllable atom–photon interaction induced by the classical field, we illustrate that the evolution trajectory of the Bell-like entanglement states can be manipulated from entanglement-sudden-death to no-entanglement-sudden-death, from no-entanglement-invariant to entanglement-invariant. Furthermore, the robustness of the initial Bell-like entanglementmore » can be improved by the classical driving field in the leaky cavities. This classical-driving-assisted architecture can be easily extensible to multi-atom quantum system for scalability.« less

Landau-Zener extension of the Tavis-Cummings model: structure of the solution

NASA Astrophysics Data System (ADS)

Sun, Chen; Sinitsyn, Nikolai

We explore the recently discovered solution of the driven Tavis-Cummings model (DTCM). It describes interaction of arbitrary number of two-level systems with a bosonic mode that has linearly time-dependent frequency. We derive compact and tractable expressions for transition probabilities in terms of the well known special functions. In the new form, our formulas are suitable for fast numerical calculations and analytical approximations. As an application, we obtain the semiclassical limit of the exact solution and compare it to prior approximations. We also reveal connection between DTCM and q-deformed binomial statistics. Under the auspices of the National Nuclear Security Administration of the U.S. Department of Energy at Los Alamos National Laboratory under Contract No. DE-AC52-06NA25396. Authors also thank the support from the LDRD program at LANL.

Quantum Entanglement in Double Quantum Systems and Jaynes-Cummings Model.

PubMed

Jakubczyk, Paweł; Majchrowski, Klaudiusz; Tralle, Igor

2017-12-01

In the paper, we proposed a new approach to producing the qubits in electron transport in low-dimensional structures such as double quantum wells or double quantum wires (DQW). The qubit could arise as a result of quantum entanglement of two specific states of electrons in DQW structure. These two specific states are the symmetric and antisymmetric (with respect to inversion symmetry) states arising due to tunneling across the structure, while entanglement could be produced and controlled by means of the source of nonclassical light. We examined the possibility to produce quantum entanglement in the framework of Jaynes-Cummings model and have shown that at least in principle, the entanglement can be achieved due to series of "revivals" and "collapses" in the population inversion due to the interaction of a quantized single-mode EM field with a two-level system.

Effects of cavity-cavity interaction on the entanglement dynamics of a generalized double Jaynes-Cummings model

NASA Astrophysics Data System (ADS)

Pandit, Mahasweta; Das, Sreetama; Singha Roy, Sudipto; Shekhar Dhar, Himadri; Sen, Ujjwal

2018-02-01

We consider a generalized double Jaynes-Cummings model consisting of two isolated two-level atoms, each contained in a lossless cavity that interact with each other through a controlled photon-hopping mechanism. We analytically show that at low values of such a mediated cavity-cavity interaction, the temporal evolution of entanglement between the atoms, under the effects of cavity perturbation, exhibits the well-known phenomenon of entanglement sudden death (ESD). Interestingly, for moderately large interaction values, a complete preclusion of ESD is achieved, irrespective of its value in the initial atomic state. Our results provide a model to sustain entanglement between two atomic qubits, under the adverse effect of cavity induced perturbation, by introducing a non-intrusive inter-cavity photon exchange that can be physically realized through cavity-QED setups in contemporary experiments.

Effect of (4a) a novel 5-HT3 receptor antagonist on chronic unpredictable mild stress induced depressive-like behavior in mice: an approach using behavioral tests battery.

PubMed

Kurhe, Yeshwant; Mahesh, Radhakrishnan; Gupta, Deepali; Thangaraj, Devadoss

2015-01-01

The inconsistent therapeutic outcome necessitates designing and identifying novel therapeutic interventions for depression. Hence, the present study deals with the investigation of antidepressant-like effects of a novel 5-HT3 receptor antagonist (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a) on chronic unpredictable mild stress (CUMS) induced behavioral and biochemical alterations. Animals were subjected to different stressors for a period of 28 days. On day 15 after the subsequent stress procedure, mice were administered with (4a) (2 and 4 mg/kg p.o.), escitalopram (10 mg/kg p.o.), or vehicle (10 mL/kg p.o.) until day 28 along with the CUMS. Thereafter, behavioral battery tests like locomotor score, sucrose preference test, forced swim test (FST), tail suspension test (TST), and elevated plus maze (EPM) were performed. Biochemical assays like lipid peroxidation, nitrite levels, reduced glutathione (GSH), catalase, and superoxide dismutase (SOD) were estimated in the mice brain homogenate. (4a) Dose dependently attenuated the behavioral alterations by increasing the sucrose consumption, reducing the immobility time in FST and TST, increasing the open arm number of entries and time in EPM. Furthermore, biochemical alterations were reversed by (4a) as examined by reduced lipid peroxidation and nitrite levels and elevated antioxidant enzyme levels like GSH, catalase and SOD. (4a) exhibits antidepressant potential by reversing the CUMS induced behavioral and biochemical changes in mice.

Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor.

PubMed

Jiang, Huili; Zhang, Xuhui; Lu, Jun; Meng, Hong; Sun, Yang; Yang, Xinjing; Zhao, Bingcong; Bao, Tuya

2018-01-01

Sensitive and stable biomarkers that facilitate depression detection and monitor the antidepressant efficiency are currently unavailable. Thus, the objective is to investigate the potential of DNA methylation and histone modifications of brain-derived neurotrophic factor (BDNF) in monitoring severity and antidepressive effects of acupuncture. The depression rat model was imitated by social isolation and chronic unpredicted mild stress (CUMS). The expression of serum BDNF was detected by enzyme-linked immunosorbent assay (ELISA), the hippocampal BDNF, acetylation levels in histone H3 lysine 9 (acH3K9), and HDAC2 by Western blot, the hippocampal mRNA of BDNF by RT-polymerase chain reaction (PCR). The DNA methylation patterns of the promoter I of BDNF was detected by MS-PCR. We investigated that the expression of BDNF in serum and hippocampus were significantly downregulated compared with controls. The same trend was found in mRNA of BDNF. Notably, acupuncture reversed the downregulation of BDNF in serum and hippocampus and mRNA of BDNF compared with model group. Acupuncture reversed the CUMS-induced downregulation of hippocampal acH3K9. On the contrary, the CUMS-induced upregulation of hippocampal HDAC2 in model group was significantly reversed by acupuncture. Collectively, the antidepressant effect of acupuncture might be mediated by regulating the DNA methylation and histone modifications of BDNF, which may represent novel biomaker for detection of depression and monitoring severity and antidepressive effects.

Ear infection - chronic

MedlinePlus

Middle ear infection - chronic; Otitis media - chronic; Chronic otitis media; Chronic ear infection ... Chole RA. Chronic otitis media, mastoiditis, and petrositis. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. ...

Entanglement transfer from two-mode continuous variable SU(2) cat states to discrete qubits systems in Jaynes-Cummings Dimers

PubMed Central

Ran, Du; Hu, Chang-Sheng; Yang, Zhen-Biao

2016-01-01

We study the entanglement transfer from a two-mode continuous variable system (initially in the two-mode SU(2) cat states) to a couple of discrete two-state systems (initially in an arbitrary mixed state), by use of the resonant Jaynes-Cummings (JC) interaction. We first quantitatively connect the entanglement transfer to non-Gaussianity of the two-mode SU(2) cat states and find a positive correlation between them. We then investigate the behaviors of the entanglement transfer and find that it is dependent on the initial state of the discrete systems. We also find that the largest possible value of the transferred entanglement exhibits a variety of behaviors for different photon number as well as for the phase angle of the two-mode SU(2) cat states. We finally consider the influences of the noise on the transferred entanglement. PMID:27553881

Dynamical critical exponent of the Jaynes-Cummings-Hubbard model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hohenadler, M.; Aichhorn, M.; Schmidt, S.

2011-10-15

An array of high-Q electromagnetic resonators coupled to qubits gives rise to the Jaynes-Cummings-Hubbard model describing a superfluid to Mott-insulator transition of lattice polaritons. From mean-field and strong-coupling expansions, the critical properties of the model are expected to be identical to the scalar Bose-Hubbard model. A recent Monte Carlo study of the superfluid density on the square lattice suggested that this does not hold for the fixed-density transition through the Mott lobe tip. Instead, mean-field behavior with a dynamical critical exponent z=2 was found. We perform large-scale quantum Monte Carlo simulations to investigate the critical behavior of the superfluid densitymore » and the compressibility. We find z=1 at the tip of the insulating lobe. Hence the transition falls in the three-dimensional XY universality class, analogous to the Bose-Hubbard model.« less

(p,q) deformations and (p,q)-vector coherent states of the Jaynes-Cummings model in the rotating wave approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ben Geloun, Joseph; Govaerts, Jan; Hounkonnou, M. Norbert

2007-03-15

Classes of (p,q) deformations of the Jaynes-Cummings model in the rotating wave approximation are considered. Diagonalization of the Hamiltonian is performed exactly, leading to useful spectral decompositions of a series of relevant operators. The latter include ladder operators acting between adjacent energy eigenstates within two separate infinite discrete towers, except for a singleton state. These ladder operators allow for the construction of (p,q)-deformed vector coherent states. Using (p,q) arithmetics, explicit and exact solutions to the associated moment problem are displayed, providing new classes of coherent states for such models. Finally, in the limit of decoupled spin sectors, our analysis translatesmore » into (p,q) deformations of the supersymmetric harmonic oscillator, such that the two supersymmetric sectors get intertwined through the action of the ladder operators as well as in the associated coherent states.« less

High resolution positron annihilation induced Auger electron spectroscopy of the CuM 2,3VV-transition and of Cu sub-monolayers on Pd and Fe

NASA Astrophysics Data System (ADS)

Mayer, J.; Hugenschmidt, C.; Schreckenbach, K.

2010-09-01

We present a high resolution positron annihilation induced Auger Electron Spectroscopy (PAES) of the CuM 2,3VV-transition with the unprecedented energy resolution of Δ/EE <1%. This energy resolution and the highly intense positron source NEPOMUC enabled us to resolve the double peak structure with PAES for the first time within a measurement time of only 5.5 h. In addition, sub-monolayers of Cu were deposited on Fe- and Pd-samples in order to investigate the surface selectivity of PAES in comparison with EAES. The extremely high surface selectivity of PAES due to the different positron affinity of Cu and Fe lead to the result that with only 0.96 monolayer of Cu on Fe more than 55% of the emitted Auger electrons stem from Cu, whereas with EAES the Cu Auger fraction amounted to less than 6%.

Effects of exposure to sonar playback sounds (3.5 - 4.1 kHz) on harbor porpoise (Phocoena phocoena) hearing.

PubMed

Kastelein, Ronald A; Helder-Hoek, Lean; Van de Voorde, Shirley

2017-10-01

Safety criteria for naval sonar sounds are needed to protect harbor porpoise hearing. Two porpoises were exposed to sequences of AN/SQS-53C sonar playback sounds (3.5-4.1 kHz, without significant harmonics), at a mean received sound pressure level of 142 dB re 1 μPa, with a duty cycle of 96% (almost continuous). Behavioral hearing thresholds at 4 and 5.7 kHz were determined before and after exposure to the fatiguing sound, in order to quantify temporary threshold shifts (TTSs) and hearing recovery. Control sessions were also conducted. Significant mean initial TTS 1-4 of 5.2 dB at 4 kHz and 3.1 dB at 5.7 kHz occurred after 30 min exposures (mean received cumulative sound exposure level, SEL cum : 175 dB re 1 μPa 2 s). Hearing thresholds returned to pre-exposure levels within 12 min. Significant mean initial TTS 1-4 of 5.5 dB at 4 kHz occurred after 60 min exposures (SEL cum : 178 dB re 1 μPa 2 s). Hearing recovered within 60 min. The SEL cum for AN/SQS-53C sonar sounds required to induce 6 dB of TTS 4 min after exposure (the definition of TTS onset) is expected to be between 175 and 180 dB re 1 μPa 2 s.

Effects of duloxetine on microRNA expression profile in frontal lobe and hippocampus in a mouse model of depression.

PubMed

Pan, Bing; Liu, Yamei

2015-01-01

Depression is a major mood disorder affecting people worldwide. The posttranscriptional gene regulation mediated by microRNAs (miRNAs) which may have critical roles in the pathogenesis of depression. However, to date, little is known about the effects of the antidepressant drug duloxetine on miRNA expression profile in chronic unpredictable mild stress (CUMS)-induced depression model in mice. Healthy adult male Kunming mice were randomly divided into three groups: control group, model group and duloxetine group. Sucrose preference test and open field test were used to represent the behavioral change. MiRNAs levels in frontal lobe and hippocampus of mice were analyzed using miRNA microarrays assay. We observed that long-term treatment with duloxetine significantly ameliorated the CUMS procedure-induced sucrose preference decreases and mice treated with duloxetine demonstrated a reversal of the number of crossings, and rearings reduced by CUMS. A significant upregulation of miR-132 and miR-18a in hippocampus in the duloxetine treatment group compared with model group, whereas the levels of miR-134 and miR-124a were significantly downregulated. Furthermore, miR-18a showed significant upregulation in frontal lobe in the duloxetine treatment group relative to model group. Our data showed that miRNA expression profile in frontal lobe and hippocampus was affected by duloxetine in mice model of depression. The effect was especially pronounced in the hippocampus, suggesting that hippocampus might be the action site of duloxetine, which presumably worked by regulating the expression of miRNA levels.

Unraveling the effect of structurally different classes of insecticide on germination and early plant growth of soybean [Glycine max (L.) Merr].

PubMed

Dhungana, Sanjeev Kumar; Kim, Il-Doo; Kwak, Hwa-Sook; Shin, Dong-Hyun

2016-06-01

Although a considerable number of studies about the effect of different insecticides on plant physiology and metabolism have been carried out, research work about the comparative action of structurally different classes of insecticide on physiological and biochemical properties of soybean seed germination and early growth has not been found. The objective of this study was to investigate the effect of different classes of insecticides on soybean seed germination and early plant growth. Soybean seeds of Bosuk cultivar were soaked for 24h in distilled water or recommended dose (2mLL(-1), 1mLL(-1), 0.5gL(-1), and 0.5gL(-1) water for insecticides Mepthion, Myungtaja, Actara, and Stonate, respectively) of pesticide solutions of four structurally different classes of insecticides - Mepthion (fenitrothion; organophosphate), Myungtaja (etofenprox; pyrethroid), Actara (thiamethoxam; neonicotinoid), and Stonate (lambda-cyhalothrin cum thiamethoxam; pyrethroid cum neonicotinoid) - which are used for controlling stink bugs in soybean crop. Insecticides containing thiamethoxam and lamda-cyhalothrin cum thiamethoxam showed positive effects on seedling biomass and content of polyphenol and flavonoid, however fenitrothion insecticide reduced the seed germination, seed and seedling vigor, and polyphenol and flavonoid contents in soybean. Results of this study reveal that different classes of insecticide have differential influence on physiologic and metabolic actions like germination, early growth, and antioxidant activities of soybean and this implies that yield and nutrient content also might be affected with the application of different types of insecticide. Copyright © 2015 Elsevier B.V. All rights reserved.

Role of Bai-Shao towards the antidepressant effect of Chaihu-Shu-Gan-San using metabonomics integrated with chemical fingerprinting.

PubMed

Chang, Xing; Jia, Hongmei; Zhou, Chao; Zhang, Hongwu; Yu, Meng; Yang, Junshan; Zou, Zhongmei

2015-12-01

Chaihu-Shu-Gan-San (CSGS) is a classical traditional Chinese medicine formula for the treatment of depression. As one of the single herbs in CSGS, Bai-Shao displayed antidepressant effect. In order to explore the role of Bai-Shao towards the antidepressant effect of CSGS, the metabolic regulation and chemical profiles of CSGS with and without Bai-Shao (QBS) were investigated using metabonomics integrated with chemical fingerprinting. At first, partial least squares regression (PLSR) analysis was applied to characterize the potential biomarkers associated with chronic unpredictable mild stress (CUMS)-induced depression. Among 46 differential metabolites found in the ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF/MS) and (1)H NMR-based urinary metabonomics, 20 were significantly correlated with the preferred sucrose consumption observed in behavior experiments and were considered as biomarkers to evaluate the antidepressant effect of CSGS. Based on differential regulation on CUMS-induced metabolic disturbances with CSGS and QBS treatments, we concluded that Bai-Shao made crucial contribution to CSGS in the improvement of the metabolic deviations of six biomarkers (i.e., glutamate, acetoacetic acid, creatinine, xanthurenic acid, kynurenic acid, and N-acetylserotonin) disturbed in CUMS-induced depression. While the chemical constituents of Bai-Shao contributed to CSGS were paeoniflorin, albiflorin, isomaltopaeoniflorin, and benzoylpaeoniflorin based on the multivariate analysis of the UPLC-Q-TOF/MS chemical profiles from CSGS and QBS extracts. These findings suggested that Bai-Shao played an indispensable role in the antidepressant effect of CSGS. Copyright © 2015 Elsevier B.V. All rights reserved.

Ondansetron attenuates depression co-morbid with obesity in obese mice subjected to chronic unpredictable mild stress; an approach using behavioral battery tests.

PubMed

Kurhe, Yeshwant; Radhakrishnan, Mahesh; Gupta, Deepali

2014-09-01

The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedures for 4 weeks. Treatment with ondansetron was started on day 15. After day 28 behavioral assays and biochemical estimations were performed. Behavioral paradigms viz. sucrose preference test, locomotor score, forced swim test (FST) and elevated plus maze (EPM), whereas biochemical parameters like plasma glucose, total cholesterol, triglycerides and total proteins were estimated. Results examines that in behavioral assays, ondansetron significantly (P < 0.05) increased sucrose consumption, reduced immobility time in FST, increased the percent entries and time in open arm in EPM. In biochemical assessments elevated plasma glucose, total cholesterol, triglycerides and total proteins were significantly (P < 0.05) reversed by ondansetron treatment in HFD obese animals subjected to CUMS. The study indicates that the obese mice subjected to CUMS exhibited severe depressive-like symptoms and ondansetron significantly reversed the behavioral and biochemical alterations. In the present study the plasma glucose level indicates that, it could be "altered glucose level" playing an important role in depression co-morbid with obesity. Ondansetron through allosteric modulation of serotonergic system elevates the serotonin level and thereby regulates the insulin secretion and hence, reversing the "altered glucose level", could be the possible antidepressive-like mechanism against depression co-morbid with obesity.

Cleft lip and palate

MedlinePlus

... 20th ed. Philadelphia, PA: Elsevier; 2016:chap 310. Wang TD, Milczuk HA. Cleft lip and palate. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head & Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 187.

Measurement of excitation functions of helion-induced reactions on enriched Ru targets for production of medically important 103Pd and 101mRh and some other radionuclides.

PubMed

Skakun, Ye; Qaim, S M

2008-05-01

Excitation functions were determined by the stacked-foil and induced radioactivity measurement technique for the reactions (100)Ru(alpha,n)(103)Pd, (101)Ru(alpha,2n)(103)Pd, (101)Ru((3)He,n)(103)Pd, and (102)Ru((3)He,2n)(103)Pd, producing the therapeutic radionuclide (103)Pd, and for the reactions (101)Ru((3)He,x)(101 m)Rh(Cum) and (102)Ru((3)He,x)(101 m)Rh(Cum), producing the medically interesting radionuclide (101 m)Rh. Data were also measured for the reactions (101)Ru((3)He,pn+d)(102 m,g)Rh, (102)Ru((3)He,p2n+dn+t)(102 m,g)Rh, (101)Ru((3)He,x)(101 g)Rh(Cum), (102)Ru((3)He,x)(101 g)Rh(Cum), (101)Ru((3)He,3n)(101)Pd, (102)Ru((3)He,4n)(101)Pd, (101)Ru((3)He,4n)(100)Pd, and (101)Ru((3)He,p3n+d2n+tn)(100)Rh, producing other palladium and rhodium isotopes/isomers. The energy ranges covered were up to 25 MeV for alpha-particles and up to 34 MeV for (3)He ions. The radioactivity of the radionuclide (103)Pd induced in thin metallic foils of the enriched ruthenium isotopes was measured by high-resolution X-ray spectrometry and the radioactivities of other radionuclides by gamma-ray spectrometry. The integral thick target yields of the radionuclide (103)Pd calculated from the excitation functions of the first four of the above-named reactions amount to 960, 1050, 50, and 725 kBq/microAh, respectively, at the maximum investigated energies of the incident particles. The integral thick target yields of the radionuclide (101 m)Rh amount to 16.1 and 2.9 MBq/microAh for (101)Ru and (102)Ru targets, respectively, at 34 MeV energy of incident (3)He ions. The integral yields of the other observed radionuclides were also deduced from the excitation functions of the above-mentioned respective nuclear reactions. The excitation functions and integral yields of some rare reaction products were also determined. The experimental excitation functions of some reactions are compared with the predictions of nuclear model calculations. In general, good agreement was obtained.

Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen Provocation

PubMed Central

Lundström, Susanna L.; Yang, Jun; Källberg, Henrik J.; Thunberg, Sarah; Gafvelin, Guro; Haeggström, Jesper Z.; Grönneberg, Reidar; Grunewald, Johan; van Hage, Marianne; Hammock, Bruce D.; Eklund, Anders; Wheelock, Åsa M.; Wheelock, Craig E.

2012-01-01

Background Asthma is a respiratory tract disorder characterized by airway hyper-reactivity and chronic inflammation. Allergic asthma is associated with the production of allergen-specific IgE and expansion of allergen-specific T-cell populations. Progression of allergic inflammation is driven by T-helper type 2 (Th2) mediators and is associated with alterations in the levels of lipid mediators. Objectives Responses of the respiratory system to birch allergen provocation in allergic asthmatics were investigated. Eicosanoids and other oxylipins were quantified in the bronchoalveolar lumen to provide a measure of shifts in lipid mediators associated with allergen challenge in allergic asthmatics. Methods Eighty-seven lipid mediators representing the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP) metabolic pathways were screened via LC-MS/MS following off-line extraction of bronchoalveolar lavage fluid (BALF). Multivariate statistics using OPLS were employed to interrogate acquired oxylipin data in combination with immunological markers. Results Thirty-two oxylipins were quantified, with baseline asthmatics possessing a different oxylipin profile relative to healthy individuals that became more distinct following allergen provocation. The most prominent differences included 15-LOX-derived ω-3 and ω-6 oxylipins. Shared-and-Unique-Structures (SUS)-plot modeling showed a correlation (R2 = 0.7) between OPLS models for baseline asthmatics (R2Y[cum] = 0.87, Q2[cum] = 0.51) and allergen-provoked asthmatics (R2Y[cum] = 0.95, Q2[cum] = 0.73), with the majority of quantified lipid mediators and cytokines contributing equally to both groups. Unique structures for allergen provocation included leukotrienes (LTB4 and 6-trans-LTB4), CYP-derivatives of linoleic acid (epoxides/diols), and IL-10. Conclusions Differences in asthmatic relative to healthy profiles suggest a role for 15-LOX products of both ω-6 and ω-3 origin in allergic inflammation. Prominent differences at baseline levels indicate that non-symptomatic asthmatics are subject to an underlying inflammatory condition not observed with other traditional mediators. Results suggest that oxylipin profiling may provide a sensitive means of characterizing low-level inflammation and that even individuals with mild disease display distinct phenotypic profiles, which may have clinical ramifications for disease. PMID:22438998

Decoherence at constant excitation

NASA Astrophysics Data System (ADS)

Torres, J. M.; Sadurní, E.; Seligman, T. H.

2012-02-01

We present a simple exactly solvable extension of the Jaynes-Cummings model by adding dissipation. This is done such that the total number of excitations is conserved. The Liouville operator in the resulting master equation can be reduced to blocks of 4×4 matrices.

Evolution and Survival of Quantum Entanglement

DTIC Science & Technology

2015-05-06

Research Triangle Park, NC 27709-2211 quantum entanglement, decoherence, qubit, revival, survival, Jaynes-Cummings, Rabi , rotating wave approximation...measurements, PHYSICAL REVIEW A , (06 2013): 62331. doi: S Agarwal, , S M Hashemi Rafsanjani , J H Eberly. Dissipation of the Rabi Model Beyond the

Cleft lip and palate repair

MedlinePlus

... 4th ed. Philadelphia, PA: Elsevier; 2016:chap 51. Wang TD, Milczuk HA. Cleft lip and palate. In: Flint PW, Haughey BH, Lund V, et al, eds. Cummings Otolaryngology: Head and Neck Surgery . 6th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 187.

The Internet in Education.

ERIC Educational Resources Information Center

Neubarth, Michael, Ed.

1995-01-01

This special theme issue of "Internet World" contains 10 articles on the role of the Internet in education. The articles are: "Internet Cum Laude" (Eric C. Richardson)--technological developments in college and university services; "Campus Connections" (Michael A. Arnzen)--guidelines for taking full advantage of…

40 CFR 90.708 - Cumulative Sum (CumSum) procedure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... is 5.0×σ, and is a function of the standard deviation, σ. σ=is the sample standard deviation and is... individual engine. FEL=Family Emission Limit (the standard if no FEL). F=.25×σ. (2) After each test pursuant...

Making Schools Work for Every Child.

ERIC Educational Resources Information Center

Thorson, Annette, Ed.

2000-01-01

This issue of "ENC Focus" explores educational equity. Featured articles provide many perspectives on gender equity, multidimensional classrooms, technology, and special needs students. Articles include: (1) "Editorial: Educational Equity--A Moving Target" (Annette Thorson); (2) "Thinking of Each and Every One" (Francena Cummings); (3) "Teacher…

ASSESSMENT OF ESTROGENICITY BY USING THE DELAYED IMPLANTING RAT MODEL AND EXAMPLES

EPA Science Inventory

Assessment of estrogenicity by using the delayed implanting rat model and examples.

Cummings AM, Laws SC.

Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, N...

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity.

PubMed

Li, Qing; Qu, Fa-Lin; Gao, Yue; Jiang, Yi-Ping; Rahman, Khalid; Lee, Kuo-Hsiung; Han, Ting; Qin, Lu-Ping

2017-03-06

There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice. Furthermore, we applied a 4 consecutive weeks of chronic unpredictable mild stress (CUMS) as a model of depression in rats, followed by a sucrose preference test. Then we examined the possible mechanisms of this action. The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations, and the protein expression levels of brain-derived neurotrophic factor (BDNF), the phosphorylated form CREB and ERK1/2 were detected by qRT-PCR or Western blot. The results showed that PS extracts (100, 200mg/kg) and PSY (12.5, 25, 50mg/kg) treatment produced antidepressant-like effects in mice similar to fluoxetine (20mg/kg), indicated by the reduced immobility time in the FST and TST, while both had no influence on the locomotor activity in the OFT. PSY treatment significantly increased sucrose preference and reduced serum CORT levels in CUMS rats. Moreover, PSY up-regulated BDNF protein levels, and increased CREB and ERK phosphorylation levels in the hippocampus on CUMS rats. These findings suggest that the antidepressant-like effects of PS extracts and PSY are mediated, at least in part, by modulating HPA axis, BDNF, CREB and ERK phosphorylation and expression in the hippocampus. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Xiao-Yao-San, a Chinese Medicine Formula, Ameliorates Chronic Unpredictable Mild Stress Induced Polycystic Ovary in Rat

PubMed Central

Sun, Hao-Yu; Li, Quan; Liu, Yu-Ying; Wei, Xiao-Hong; Pan, Chun-Shui; Fan, Jing-Yu; Han, Jing-Yan

2017-01-01

Chronic stress induces endocrine disturbance, which contributes to the development of polycystic ovary syndrome (PCOS), a condition that remains a challenge for clinicians to cope with. The present study investigated the effect of Xiao-Yao-San (XYS), a traditional Chinese medicine formula used for treatment of gynecological disease, on the chronic stress-induced polycystic ovary and its underlying mechanism. Female Sprague-Dwaley rats underwent a 3 weeks chronic unpredictable mild stress (CUMS) procedure to establish the PCOS model, followed by 4 weeks treatment with XYS (0.505 g/kg or 1.01 g/kg) by gavage. Granulosa cells were exposed to noradrenaline (1 mM) in vitro for 24 h, followed by incubation with or without XYS-treated rat serum for 24 h. Post-treatment with XYS ameliorated CUMS-induced irregular estrous cycles and follicles development abnormalities, decrease of estradiol and progesterone level as well as increase of luteinizing hormone in serum, reduced cystic follicles formation and the apoptosis and autophagy of granulosa cells, attenuated the increase in dopamine beta hydroxylase and c-fos level in locus coeruleus, the noradrenaline level in serum and ovarian tissue, and the expression of beta 2 adrenergic receptor in ovarian tissue. Besides, XYS alleviated the reduction of phosphorylation of ribosomal protein S6 kinase polypeptide I and protein kinase B, as well as the increase of microtubule-associated protein light chain 3-I to microtubule-associated protein light chain 3-II conversion both in vivo and in vitro. This study demonstrated XYS as a potential strategy for CUMS induced polycystic ovary, and suggested that the beneficial role of XYS was correlated with the regulation of the sympathetic nerve activity. PMID:29018356

Substorm wave base felsic hydroclastic deposits in the Archean Lac des Vents volcanic complex, Abitibi belt, Canada

NASA Astrophysics Data System (ADS)

Mueller, Wulf; Chown, E. H.; Potvin, Robin

1994-05-01

Volcaniclastic deposits of the 2.3-km-thick Archean Lac des Vents volcanic complex are an integral part of major submarine volcanic construction. The volcanic edifice, which formed on a subaqueous basalt plain, is comparable to modern seamounts resting on the ocean floor. The initial 770 m of the mafic-felsic edifice, subject of this study, is composed of massive, brecciated and pillowed basalts, massive to brecciated felsic lava flows and abundant felsic fragmental rocks of hydroclastic origin. Four distinct volcaniclastic lithofacies constitute the latter: (1) the pumice lapilli-tuff lithofacies; (2) the lapilli-tuff breccia lithofacies characterized by two sublithofacies; (3) the turbidite tuff and tuff-breccia lithofacies; and (4) the volcanic sandstone and breccia lithofacies. These four volcaniclastic lithofacies are considered to be the result of explosive and non-explosive hydrovolcanic fragmentation processes operating at depths below storm wave base (> 200 m). Primary deposition or limited remobilization of unconsolidated hydroclastic debris is shown by the preservation of delicate clasts and volcanic textures, and heat retention structures. The principal transport agents are high-concentration sediment gravity flows occurring under laminar and turbulent flow conditions. High- and low-density turbiditic tuffs and fine-grained tuff fallout deposits, are related to either the dissipating stages of volcanic eruptions or slumping of syneruptive volcanic debris on the flanks of a subaqueous volcanic edifice. Ubiquitous interstratification of volcaniclastic turbidites, shale, and pillowed basalt flows with the felsic lava flows and fragmental debris favours subaqueous deposition. These features combined with the absence of wave-induced sedimentary structures, imply deposition in water depths in excess of 200 m. Viscous feldspar-phyric massive and brecciated felsic flows, and associated volcaniclastics cross cut by felsic dykes, suggest vent proximity. The abundance of breccia-size hydroclastic debris is consistent with this interpretation. Collectively, these criteria argue for subaqueous fragmentation and deposition of volcaniclastics of inferred hydroclastic origin close to the central vent area at depths below storm wave base.

Sources of Environmental Structuring and Participant Responses.

DTIC Science & Technology

1982-04-08

Berger & Cummings, 1979; Dalton, Todor , Spendolini, 1. at 6 Environmental Structuring Fielding, & Porter, 1980).2 While none of these reviews...1951, 16, 297-334. Dalton, D. R., Todor , W. D., Spendolini, M. J., Fielding, G. J., & Porter, L. W. Organization structure and performance: A critical

Comparative Perspectives on the Academic Profession.

ERIC Educational Resources Information Center

Altbach, Philip G., Ed.

Essays include: gentlemen and players, the changing British professoriate (Gareth Williams); the robed baron, the academic profession in the Italian university (Guido Martinotti, Alberto Giasanti); the changing role of the Japanese professor (William K. Cummings, Ikuo Amano); academic staff and academic drift in Australian colleges of advanced…

Analytical Solution for the Anisotropic Rabi Model: Effects of Counter-Rotating Terms

NASA Astrophysics Data System (ADS)

Zhang, Guofeng; Zhu, Hanjie

2015-03-01

The anisotropic Rabi model, which was proposed recently, differs from the original Rabi model: the rotating and counter-rotating terms are governed by two different coupling constants. This feature allows us to vary the counter-rotating interaction independently and explore the effects of it on some quantum properties. In this paper, we eliminate the counter-rotating terms approximately and obtain the analytical energy spectrums and wavefunctions. These analytical results agree well with the numerical calculations in a wide range of the parameters including the ultrastrong coupling regime. In the weak counter-rotating coupling limit we find out that the counter-rotating terms can be considered as the shifts to the parameters of the Jaynes-Cummings model. This modification shows the validness of the rotating-wave approximation on the assumption of near-resonance and relatively weak coupling. Moreover, the analytical expressions of several physics quantities are also derived, and the results show the break-down of the U(1)-symmetry and the deviation from the Jaynes-Cummings model.

Analytical solution for the anisotropic Rabi model: effects of counter-rotating terms.

PubMed

Zhang, Guofeng; Zhu, Hanjie

2015-03-04

The anisotropic Rabi model, which was proposed recently, differs from the original Rabi model: the rotating and counter-rotating terms are governed by two different coupling constants. This feature allows us to vary the counter-rotating interaction independently and explore the effects of it on some quantum properties. In this paper, we eliminate the counter-rotating terms approximately and obtain the analytical energy spectrums and wavefunctions. These analytical results agree well with the numerical calculations in a wide range of the parameters including the ultrastrong coupling regime. In the weak counter-rotating coupling limit we find out that the counter-rotating terms can be considered as the shifts to the parameters of the Jaynes-Cummings model. This modification shows the validness of the rotating-wave approximation on the assumption of near-resonance and relatively weak coupling. Moreover, the analytical expressions of several physics quantities are also derived, and the results show the break-down of the U(1)-symmetry and the deviation from the Jaynes-Cummings model.

The ecological dimension of psychoanalysis and the concept of inner sustainability.

PubMed

Ley, Wolfgang

2008-12-01

An "ecological-cum-psychoanalytic" perspective elucidates the innate kinship between modern, critical ecological thinking and the assumptions on the nature of the human animal underlying Freudian psychoanalysis. "Critical ecology" engages with the issues posed by a meaningful, "sustainable" design for the relationship between nature and culture; psychoanalysis investigates and engages therapeutically with human self-relations in the field of tension existing between the culture-imprinted and culture-productive "ego," on the one hand, and the independent, naturally established motivational sides of the psyche subsumed by Freud under the term "id" on the other. Against an ecological-cum-psychoanalytic backdrop, modern developments in object relations theory and self psychology can be understood in a way that places them in a conceptual framework corresponding to Freud's central concern with the balance or integration-successful or unsuccessful-of the motivational (interactional) strivings of "internal nature" and the requirements posed by human "self-production" via culture. Psychoanalysis and critical ecology, it is argued, stand to profit from one another.

Time evolution of the one-dimensional Jaynes-Cummings-Hubbard Hamiltonian

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makin, M. I.; Hill, Charles D.; Greentree, Andrew D.

2009-10-15

The Jaynes-Cummings-Hubbard (JCH) system describes a network of single-mode photonic cavities connected via evanescent coupling. Each cavity contains a single two-level system which can be tuned in resonance with the cavity. Here, we explore the behavior of single excitations (where an excitation can be either photonic or atomic) in the linear JCH system, which describes a coupled cavity waveguide. We use direct, analytic diagonalization of the Hamiltonian to study cases where intercavity coupling is either uniform or varies parabolically along the chain. Both excitations located in a single cavity, as well as one excitation as a Gaussian pulse spread overmore » many cavities, are investigated as initial states. We predict unusual behavior of this system in the time domain, including slower than expected propagation of the excitation and also splitting of the excitation into two distinct pulses, which travel at distinct speeds. In certain limits, we show that the JCH system mimics two Heisenberg spin chains.« less

Entanglement dynamics of two independent Jaynes-Cummings atoms without the rotating-wave approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen Qinghu; Department of Physics, Zhejiang University, Hangzhou 310027; Yang Yuan

2010-11-15

Entanglement evolution of two independent Jaynes-Cummings atoms without the rotating-wave approximation (RWA) is studied by a numerically exact approach. Previous results based on the RWA are essentially modified in the strong-coupling regime (g{>=}0.1), which has been reached in the recent experiments on the flux qubit coupled to the LC resonator. For the initial Bell state with anticorrelated spins, entanglement sudden death (ESD) is absent in the RWA but does appear in the present numerical calculation without the RWA. Aperiodic entanglement evolution in the strong-coupling regime is observed. The strong atom-cavity coupling facilitates the ESD. The sign of the detuning playsmore » an essential role in the entanglement evolution for strong coupling, which is irrelevant in the RWA. Analytical results based on an unitary transformation are also given, which could not modify the RWA picture essentially. It is suggested that the activation of the photons may be the origin of ESD in this system.« less

Initial correlations in open-systems dynamics: The Jaynes-Cummings model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smirne, Andrea; Vacchini, Bassano; INFN, Sezione di Milano, Via Celoria 16, I-20133 Milano

2010-12-15

Employing the trace distance as a measure for the distinguishability of quantum states, we study the influence of initial correlations on the dynamics of open systems. We concentrate on the Jaynes-Cummings model for which the knowledge of the exact joint dynamics of system and reservoir allows the treatment of initial states with arbitrary correlations. As a measure for the correlations in the initial state we consider the trace distance between the system-environment state and the product of its marginal states. In particular, we examine the correlations contained in the thermal equilibrium state for the total system, analyze their dependence onmore » the temperature and on the coupling strength, and demonstrate their connection to the entanglement properties of the eigenstates of the Hamiltonian. A detailed study of the time dependence of the distinguishability of the open system states evolving from the thermal equilibrium state and its corresponding uncorrelated product state shows that the open system dynamically uncovers typical features of the initial correlations.« less

International nurse recruitment in India.

PubMed

Khadria, Binod

2007-06-01

This paper describes the practice of international recruitment of Indian nurses in the model of a "business process outsourcing" of comprehensive training-cum-recruitment-cum-placement for popular destinations like the United Kingdom and United States through an agency system that has acquired growing intensity in India. Despite the extremely low nurse to population ratio in India, hospital managers in India are not concerned about the growing exodus of nurses to other countries. In fact, they are actively joining forces with profitable commercial ventures that operate as both training and recruiting agencies. Most of this activity is concentrated in Delhi, Bangalore, and Kochi. Gaps in data on nursing education, employment, and migration, as well as nonstandardization of definitions of "registered nurse," impair the analysis of international migration of nurses from India, making it difficult to assess the impact of migration on vacancy rates. One thing is clear, however, the chain of commercial interests that facilitate nurse migration is increasingly well organized and profitable, making the future growth of this business a certainty.

On the interaction of sound with an annular aperture in a mean flow duct

NASA Astrophysics Data System (ADS)

Schleicher, R. M.; Howe, M. S.

2013-10-01

An analysis is made of long wavelength sound interacting with a thin, rigid disc placed axisymmetrically across a circular cylindrical duct in the presence of a low Mach number mean flow. Vorticity produced at the edge of the disc causes an overall loss of acoustic energy, the effect of which is increased by the flow. Calculations are performed to derive a new analytical representation of the Rayleigh conductivity of the annular aperture between the disc and the duct wall, and a quasi-steady approximation is used to determine the unsteady drag on the disc. The results are used to estimate the corrected form of the conductivity in the presence of flow. This permits the Cummings-Fant ‘reduced complexity’ equation to be applied to study the absorption of acoustic energy at the disc [A. Cummings, American Institute of Aeronautics and Astronautics Journal 22 (1984) 786-792; G. Fant, Acoustic Theory of Speech Production, The Hague, Mouton, 1960].

Analytical Solution for the Anisotropic Rabi Model: Effects of Counter-Rotating Terms

PubMed Central

Zhang, Guofeng; Zhu, Hanjie

2015-01-01

The anisotropic Rabi model, which was proposed recently, differs from the original Rabi model: the rotating and counter-rotating terms are governed by two different coupling constants. This feature allows us to vary the counter-rotating interaction independently and explore the effects of it on some quantum properties. In this paper, we eliminate the counter-rotating terms approximately and obtain the analytical energy spectrums and wavefunctions. These analytical results agree well with the numerical calculations in a wide range of the parameters including the ultrastrong coupling regime. In the weak counter-rotating coupling limit we find out that the counter-rotating terms can be considered as the shifts to the parameters of the Jaynes-Cummings model. This modification shows the validness of the rotating-wave approximation on the assumption of near-resonance and relatively weak coupling. Moreover, the analytical expressions of several physics quantities are also derived, and the results show the break-down of the U(1)-symmetry and the deviation from the Jaynes-Cummings model. PMID:25736827

Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation.

PubMed

Chen, Wei-Guan; Zheng, Jia-Xuan; Xu, Xi; Hu, Yu-Ming; Ma, Yu-Min

2018-06-01

As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC). Overexpression of hippocampal FXR induced notable depressive-like behaviors and decreased expression of brain-derived neurotrophic factor (BDNF) in naïve rats, while knockdown of hippocampal FXR fully prevented the effects of CUMS on rat behaviors and hippocampal BDNF expression. Taken together, our research extends the knowledge of FXR's role in the central nervous system, and may provide a potential and novel therapeutic target for treating depression. Copyright © 2018 Elsevier B.V. All rights reserved.

Differential regulation of catecholamine synthesis and transport in rat adrenal medulla by fluoxetine treatment.

PubMed

Spasojevic, Natasa; Jovanovic, Predrag; Dronjak, Sladjana

2015-03-01

We have recently shown that chronic fluoxetine treatment acted significantly increasing plasma norepinephrine and epinephrine concentrations both in control and chronically stressed adult male rats. However, possible effects of fluoxetine on catecholamine synthesis and re-uptake in adrenal medulla have been largely unknown. In the present study the effects of chronic fluoxetine treatment on tyrosine hydroxylase, a rate-limiting enzyme in catecholamine synthesis, as well as a norepinephrine transporter and vesicular monoamine transporter 2 gene expressions in adrenal medulla of animals exposed to chronic unpredictable mild stress (CUMS) for 4 weeks, were investigated. Gene expression analyses were performed using a real-time quantitative reverse transcription-PCR. Chronically stressed animals had increased tyrosine hydroxylase mRNA levels and decreased expression of both transporters. Fluoxetine increased tyrosine hydroxylase and decreased norepinephrine transporter gene expression in both unstressed and CUMS rats. These findings suggest that chronic fluoxetine treatment increased plasma catecholamine levels by affecting opposing changes in catecholamine synthesis and uptake.

High Assurance Human-Centric Decision Systems

DTIC Science & Technology

2013-05-01

of the human operator who is multitasking in this situation. 38 Crandall, Cummings, and Mitchell [7], [8] have introduced “fan-out” models to estimate...planning in multitasking contexts. In the future, we will study extensions of our cog- nitive model. Currently, the cognitive model is focused solely

Hechtius (1795-1798)--The Beginnings of Historical-Philosophical-Idiographic Research in Comparative Education

ERIC Educational Resources Information Center

Lenhart, Volker

2018-01-01

From its very beginnings, we can discern two methodological approaches to comparative education; one broadly historical-philosophical-idiographic and another broadly empirical-positivist-nomothetic. Friedrich August Hecht's 1795-1798 "De re scholastica Anglica cum Germanica comparata" ("English and German school education…

40 CFR 1045.315 - How do I know when my engine family fails the production-line testing requirements?

Code of Federal Regulations, 2013 CFR

2013-07-01

... and CO emissions: Ci = Max [0 or Ci−1 + Xi − (STD + 0.25 × σ)] Where: Ci = The current CumSum...). Xi = The current emission test result for an individual engine. STD = Emission standard (or family...

40 CFR 1048.315 - How do I know when my engine family fails the production-line testing requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... and CO emissions: Ci = Max [0 or Ci-1 + Xi − (STD + 0.25 × σ)] Where: Ci = The current CumSum...). Xi = The current emission test result for an individual engine. STD = Emission standard. (c) Use...

40 CFR 1054.315 - How do I know when my engine family fails the production-line testing requirements?

Code of Federal Regulations, 2010 CFR

2010-07-01

... and CO emissions: Ci = Max [0 or Ci-1 + Xi−(STD + 0.25 × σ)] Where: Ci = The current CumSum statistic...). Xi = The current emission test result for an individual engine. STD = Emission standard (or family...

40 CFR 1045.315 - How do I know when my engine family fails the production-line testing requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... and CO emissions: Ci = Max [0 or Ci−1 + Xi − (STD + 0.25 × σ)] Where: Ci = The current CumSum...). Xi = The current emission test result for an individual engine. STD = Emission standard (or family...

EPA's SHEDS-multimedia model: children's cumulative pyrethroid exposure estimates and evaluation against NHANES biomarker data

EPA Science Inventory

The U.S. EPA's SHEDS-Multimedia model was applied to enhance the understanding of children's exposures and doses to multiple pyrethroid pesticides, including major contributing chemicals and pathways. This paper presents combined dietary and residential exposure estimates and cum...

COMBINED EFFECTS OF METALS AND STRESS ON CENTRAL NERVOUS SYSTEM FUNCTION

EPA Science Inventory

Chemical exposures do not occur in isolation but concurrently with other risk factors for human diseases and disorders, including host, genetic and lifestyle risk factors. This application asks two crucial questions in relation to the inclusion of non-chemical stressors in cum...

Collaborative Research to Optimize Warfighter Nutrition (CROWN)

DTIC Science & Technology

2014-09-01

10.1002/oby.20075. PMID: 23592679 2. Margolis LM, Rood J, Champagne C, Young AJ, Castellani JW. Energy balance and body composition during US Army... Champagne , C., Carpentieri, D. M., Cummings, C. M., Young, A. J., Montain, S. J., & Scisco, J. L. (2014, November). Using an environmental

Adolescent Substance Abuse.

ERIC Educational Resources Information Center

Thorne, Craig R.; DeBlassie, Richard R.

1985-01-01

Cummings (1979), citing evidence from the National Institute of Drug Abuse, reports that one of every eleven adult Americans suffers from a severe addictive problem. Drug addiction is epidemic among teenagers; one of every six teenagers suffers from a severe addictive problem. This paper focuses on adolescent drug/substance abuse. (Author)

Environmental Development cum Forest Plantation Planning and Management.

ERIC Educational Resources Information Center

Katoch, C. D.

This textbook covers environmental conservation through forest plantation planning and management for all levels of forestry professionals and non-professionals in India and abroad. The book is divided into six parts and 29 sections in sequential order. Part I contains details on site selection, site preparations, site clearance, layout, and…

Children's Representations of Family Relationships, Peer Information Processing, and School Adjustment

ERIC Educational Resources Information Center

Bascoe, Sonnette M.; Davies, Patrick T.; Sturge-Apple, Melissa L.; Cummings, E. Mark

2009-01-01

This study examined children's peer information processing as an explanatory mechanism underlying the association between their insecure representations of interparental and parent-child relationships and school adjustment in a sample of 210 first graders. Consistent with emotional security theory (P. T. Davies & E. M. Cummings, 1994), results…

Can the Japanese Change Their Education System?

ERIC Educational Resources Information Center

Goodman, Roger, Ed.; Phillips, David, Ed.

The nine papers included in this book are: "The Why, What and How of Educational Reform in Japan" (Roger Goodman); "Why Reform Japanese Education?" (William K. Cummings); "Destruction and Reconstruction: A Comparative Analysis of the Education Reform in Japan and Germany under the U.S. Military Occupation After World War…

40 CFR 91.509 - Calculation and reporting of test results.

Code of Federal Regulations, 2011 CFR

2011-07-01

... applicable emission standard expressed to one additional significant figure. (ASTM E29-93a has been... contained in the applicable standard expressed to one additional significant figure. (c) The final... expressed to one additional significant figure. (d) If, at any time during the model year, the CumSum...

40 CFR 91.509 - Calculation and reporting of test results.

Code of Federal Regulations, 2014 CFR

2014-07-01

... applicable emission standard expressed to one additional significant figure. (ASTM E29-93a has been... contained in the applicable standard expressed to one additional significant figure. (c) The final... expressed to one additional significant figure. (d) If, at any time during the model year, the CumSum...

The First Treatise in Comparative Education Rediscovered

ERIC Educational Resources Information Center

Lenhart, Volker

2016-01-01

The Latin essay "De re Scholastica Anglica cum Germanica Comparata" (English and German school education compared) published in 1795-1798 by the Freiberg/Saxony grammar school principal Friedrich August Hecht is the first treatise in comparative education. The rediscovery of the text, its earlier mentioning in the history of comparative…

Contra Aquam Remigare: Reimagining Humanistic Paideia through Comparative-Historical Analysis of Education

ERIC Educational Resources Information Center

Roussakis, Yiannis

2018-01-01

This article attempts a reading of Andreas M. Kazamias's work and method as a persistent and firmly grounded attempt to "go against the tide" of an empirical/instrumentalist comparative education and toward a "modernist 'episteme.'" Kazamias has been explicitly critical of the social-scientific-cum-positivist comparative…

Surveying Graduate Students' Attitudes and Approaches to Problem Solving

ERIC Educational Resources Information Center

Mason, Andrew; Singh, Chandralekha

2010-01-01

Students' attitudes and approaches to problem solving in physics can profoundly influence their motivation to learn and development of expertise. We developed and validated an Attitudes and Approaches to Problem Solving survey by expanding the Attitudes toward Problem Solving survey of Marx and Cummings and administered it to physics graduate…

The Iconography of Universities as Institutional Narratives

ERIC Educational Resources Information Center

Drori, Gili S.; Delmestri, Giuseppe; Oberg, Achim

2016-01-01

The coming of "brand society" and the onset of mediatization spur universities to strategize their visual identity and pay particular attention to their icon. Resulting from branding initiatives, university icons are visual self-representations and material-cum-symbolic forms of organizational identity. In this work we ask: What identity…

An Enhanced Studio Physics Model: Which Technologies are Productive?

ERIC Educational Resources Information Center

MacKinnon, Gregory R.; Williams, Peter

2006-01-01

The notion of problem-based physics laboratories enhanced by computer technology has been coined "studio physics" (Wilson, 1994) and has been practised at various institutions for some time (Cummings, Marx, Thornton, & Kuhl, 1999; Williams, MacLatchy, Backman, & Retson, 1997). In recent years, new technology tools have been available to supplement…

Constructing Confidence Intervals for Reliability Coefficients Using Central and Noncentral Distributions.

ERIC Educational Resources Information Center

Weber, Deborah A.

Greater understanding and use of confidence intervals is central to changes in statistical practice (G. Cumming and S. Finch, 2001). Reliability coefficients and confidence intervals for reliability coefficients can be computed using a variety of methods. Estimating confidence intervals includes both central and noncentral distribution approaches.…

32 CFR 761.3 - Authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

...; 3 CFR, 1943 Cum. Supp., p. 504). (iv) Johnston Island Naval Defensive Sea Area; Johnston Island... territorial waters: (1) Johnston Island—Executive Order 6935 of December 29, 1934 as amended by Executive... (Kwajalein Atoll) and of the Defense Nuclear Agency (Eniwetok Atoll) see § 761.4) is controlled by the High...

32 CFR 761.3 - Authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

...; 3 CFR, 1943 Cum. Supp., p. 504). (iv) Johnston Island Naval Defensive Sea Area; Johnston Island... territorial waters: (1) Johnston Island—Executive Order 6935 of December 29, 1934 as amended by Executive... (Kwajalein Atoll) and of the Defense Nuclear Agency (Eniwetok Atoll) see § 761.4) is controlled by the High...

32 CFR 761.3 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

...; 3 CFR, 1943 Cum. Supp., p. 504). (iv) Johnston Island Naval Defensive Sea Area; Johnston Island... territorial waters: (1) Johnston Island—Executive Order 6935 of December 29, 1934 as amended by Executive... (Kwajalein Atoll) and of the Defense Nuclear Agency (Eniwetok Atoll) see § 761.4) is controlled by the High...

32 CFR 761.3 - Authority.

Code of Federal Regulations, 2014 CFR

2014-07-01

...; 3 CFR, 1943 Cum. Supp., p. 504). (iv) Johnston Island Naval Defensive Sea Area; Johnston Island... territorial waters: (1) Johnston Island—Executive Order 6935 of December 29, 1934 as amended by Executive... (Kwajalein Atoll) and of the Defense Nuclear Agency (Eniwetok Atoll) see § 761.4) is controlled by the High...

32 CFR 761.3 - Authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

...; 3 CFR, 1943 Cum. Supp., p. 504). (iv) Johnston Island Naval Defensive Sea Area; Johnston Island... territorial waters: (1) Johnston Island—Executive Order 6935 of December 29, 1934 as amended by Executive... (Kwajalein Atoll) and of the Defense Nuclear Agency (Eniwetok Atoll) see § 761.4) is controlled by the High...

Cotoneaster Medik.: cotoneaster

Treesearch

Paul E. Slabaugh; Nancy L. Shaw

2008-01-01

The genus Cotoneaster includes about 50 species of shrubs and small trees native to the temperate regions of Europe, northern Africa, and Asia (excepting Japan) (Cumming 1960). Growth habits range from nearly prostrate to upright. Coldhardy types are more or less deciduous, whereas those native to warmer regions are evergreen (Heriteau 1990). Cotoneasters are valued as...

Teacher's Professional Development from Vygotskian Optique

ERIC Educational Resources Information Center

Shabani, Karim

2012-01-01

Vygotsky's concept of ZPD (Zone of Proximal Development) has been recently applied to the context of language teacher education by a number of researchers (e.g. Ohta, 2005; Singh & Richards, 2006; Nassaji & Cumming, 2000). Besides Vygotsky's notion of ZPD, this paper relies on two associated theories from outside the TESOL discipline…

Data Assimilation Considerations for Improved Ocean Predictability During the Gulf of Mexico Grand Lagrangian Deployment (GLAD)

DTIC Science & Technology

2014-09-16

scales below the mesoscale are achievable. Other planned observation systems include the Surface Water/Ocean Topography ( SWOT ) satellite mission...atmospheric. Oceanic Hydrol. Appl . II, Chapter 13. Cummings, J., Bertino, L., Brasseur, P., Fukumori, I., Kamachi, M., Martin, M.J., Mogensen, K

ATRAZINE EFFECTS ON EARLY PREGNANCY AND IMPLANATION IN THE RAT

EPA Science Inventory

Atrazine Effects on Early Pregnancy and Implantation in the Rat.
A.M. Cummings, B.E. Rhodes*, and R.L. Cooper*.
Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, NC
Atrazine (ATR), an herbicide, can induce mammary tumors in rats. ATR can also sup...

Adult Literacy and Numeracy: Assessing Change. Adult Literacy Research Network.

ERIC Educational Resources Information Center

Cumming, J. Joy, Ed.; van Kraayenoord, Christina E., Ed.

This document contains eight papers from an action research program to foster good practice in adult literacy provision and policy. "Introduction" (J. Joy Cumming, Christina E. van Kraayenoord) presents an overview of the action research project and individual reports. "Assessment: Making a Difference in Adult Literacy and Numeracy…

Immiseration Capitalism, Activism and Education: Resistance, Revolt and Revenge

ERIC Educational Resources Information Center

Hill, Dave

2012-01-01

This is a panoptic paper in five parts. In Part One, Immiseration Capitalism, I examine the current neoliberal cum neoconservative austerity capitalism and its "class war from above", in particular its resultant relative immiseration and its absolute immiseration, with particular reference to Greece, Ireland, Britain and the USA. In Part…

Employment-cum-Training Contracts in France: The 1975-85 Record.

ERIC Educational Resources Information Center

Caspar, M.-L.

1988-01-01

The author evaluates a program whereby the French government subsidized employers to organize training for youth under employment contracts. Youth with above average employment opportunties benefited. Failure to serve the most disadvantaged youth is attributed to (1) individual youth choices, (2) screening by program administrators, and (3)…

Ecological Interactions of Bacteria in the Human Gut

NASA Astrophysics Data System (ADS)

Falony, Gwen; de Vuyst, Luc

The colon or large intestine is one of the most important organs of the human body (Macfarlane and Cummings, 1991). Moreover, its inhabitants, the colon microbiota, are the key elements of the human digestive ecosystem. The vast complexity of the human large-intestinal microbiota has inspired researchers to consider it as an organ itself, located inside the colon and acquired postnatally (Bäckhed et al., 2005; Zocco et al., 2007). From a physiologist's point of view, this image of the colon microbiota is relevant: like an organ, it is composed of different cell lineages that communicate with both one another and the host; it consumes, stores, and redistributes energy; it mediates physiologically important chemical transformations; and it is able to maintain and repair itself through self-replication (Bäckhed et al., 2005). As a microbial organ, the human colon community does not only broaden the digestive abilities of the host (Gill et al., 2006), but also influences body processes far beyond digestion (Roberfroid, 2005b; Turnbaugh et al., 2007).

Tracking Learners' Progress: Adopting a Dual "Corpus cum Experimental Data" Approach

ERIC Educational Resources Information Center

Meunier, Fanny; Littre, Damien

2013-01-01

The article discusses the potential of combining learner corpus research with experimental studies in order to fine-tune the understanding of learner language development. It illustrates the complementarity of the two methodological approaches with data from an ongoing study of the acquisition of the English tense and aspect system by French…

Soil-profile distribution of organic C and N at the end of 6 years of tillage and grazing management

USDA-ARS?s Scientific Manuscript database

Stocks of soil organic carbon (SOC) and total soil nitrogen (TSN) are key determinants for evaluating agricultural management practices to address climate change, environmental quality, and soil productivity issues. We determined SOC, TSN, and particulate organic C and N depth distributions and cum...

Online Help for Problem Gambling among Chinese Youths

ERIC Educational Resources Information Center

Lee, Chang Boon Patrick

2011-01-01

The objectives of this study were to determine the perceptions and accessibility of online help for problem gambling among Chinese youths. A group of undergraduates participated in a survey cum laboratory exercise to search for help for problem gambling in Macao, Hong Kong, and China. Online search engines were used. During the search process,…

77 FR 13251 - Endangered and Threatened Wildlife and Plants; Initiation of a 5-Year Review of Nine Northeastern...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

... Shenandoah salamander. We will also review the following threatened species: Knieskern's beaked-rush, small...; 57 FR 54722. Shenandoah salamander Plethodon Endangered........ U.S.A.; VA........ August 18, 1989..., 330 Cummings Street, Abingdon, VA 24210. Shenandoah salamander....... Cindy Schulz, (804) U.S. Fish...

Ergonomic Based Design and Survey of Elementary School Furniture

ERIC Educational Resources Information Center

Maheshwar; Jawalkar, Chandrashekhar S.

2014-01-01

This paper presents the ergonomic aspects in designing and prototyping of desks cum chairs used in elementary schools. The procedures adopted for the assessment included: the study of existing school furniture, design analysis and development of prototypes. The design approach proposed a series of adjustable desks and chairs developed in terms of…

Virtual and Traditional Feedback-Seeking Behaviors: Underlying Competitive Attitudes and Consequent Grade Performance

ERIC Educational Resources Information Center

Hwang, Alvin; Arbaugh, J. B.

2006-01-01

The electronic medium continues to play an increasingly important role in the delivery of management education despite a paucity of empirical studies on its impact and efficacy. Results from a study of competitive attitudes and feedback-seeking behaviors across seven "hybrid" electronic cum live classes showed that…

Colloquamur Latine cum Pueris Puellesque: Latin in the Middle School.

ERIC Educational Resources Information Center

Graber, Charles F.; Norton, Harriet S.

Guidelines for the development of a Latin curriculum for the middle school, with specific suggestions as to content and methodology, are presented in this manual. The material, oriented toward new approaches in the teaching of the Latin and Graeco-Roman cultures, strives to develop proficiency in the skills of listening, speaking, reading, and…

Decisionmaking in Operation Iraqi Freedom: Removing Saddam Hussein by Force

DTIC Science & Technology

2010-02-01

have been to abandon diplomacy, but British Prime Minister Tony Blair warned that without a second resolution (or, at least, a serious effort to... Robbins and Jeanne Cummings, “New Doctrine: How Bush Decided That Iraq’s Hussein Must Be Ousted,” Wall Street Journal, June 14, 2002. 58. National

Exploring the quantum critical behaviour in a driven Tavis–Cummings circuit

PubMed Central

Feng, M.; Zhong, Y.P.; Liu, T.; Yan, L.L.; Yang, W.L.; Twamley, J.; Wang, H.

2015-01-01

Quantum phase transitions play an important role in many-body systems and have been a research focus in conventional condensed-matter physics over the past few decades. Artificial atoms, such as superconducting qubits that can be individually manipulated, provide a new paradigm of realising and exploring quantum phase transitions by engineering an on-chip quantum simulator. Here we demonstrate experimentally the quantum critical behaviour in a highly controllable superconducting circuit, consisting of four qubits coupled to a common resonator mode. By off-resonantly driving the system to renormalize the critical spin-field coupling strength, we have observed a four-qubit nonequilibrium quantum phase transition in a dynamical manner; that is, we sweep the critical coupling strength over time and monitor the four-qubit scaled moments for a signature of a structural change of the system's eigenstates. Our observation of the nonequilibrium quantum phase transition, which is in good agreement with the driven Tavis–Cummings theory under decoherence, offers new experimental approaches towards exploring quantum phase transition-related science, such as scaling behaviours, parity breaking and long-range quantum correlations. PMID:25971985

Exact treatment of the Jaynes-Cummings model under the action of an external classical field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdalla, M. Sebawe, E-mail: m.sebaweh@physics.org; Khalil, E.M.; Mathematics Department, College of Science, Taibah University, Al-MaDinah

2011-09-15

We consider the usual Jaynes-Cummings model (JCM), in the presence of an external classical field. Under a certain canonical transformation for the Pauli operators, the system is transformed into the usual JCM. Using the equations of motion in the Heisenberg picture, exact solutions for the time-dependent dynamical operators are obtained. In order to calculate the expectation values of these operators, the wave function has been constructed. It has been shown that the classical field augments the atomic frequency {omega}{sub 0} and mixes the original atomic states. Changes of squeezing from one quadrature to another is also observed for a strongmore » value of the coupling parameter of the classical field. Furthermore, the system in this case displays partial entanglement and the state of the field losses its purity. - Highlights: > The time-dependent JCM, in the presence of the classical field, is still one of the essential problems in the quantum optics. > A new approach is applied through a certain canonical transformation. > The classical field augments the atomic frequency {omega}{sub 0} and mixes the original atomic states.« less

Parity Deformed Jaynes-Cummings Model: “Robust Maximally Entangled States”

PubMed Central

Dehghani, A.; Mojaveri, B.; Shirin, S.; Faseghandis, S. Amiri

2016-01-01

The parity-deformations of the quantum harmonic oscillator are used to describe the generalized Jaynes-Cummings model based on the λ-analog of the Heisenberg algebra. The behavior is interestingly that of a coupled system comprising a two-level atom and a cavity field assisted by a continuous external classical field. The dynamical characters of the system is explored under the influence of the external field. In particular, we analytically study the generation of robust and maximally entangled states formed by a two-level atom trapped in a lossy cavity interacting with an external centrifugal field. We investigate the influence of deformation and detuning parameters on the degree of the quantum entanglement and the atomic population inversion. Under the condition of a linear interaction controlled by an external field, the maximally entangled states may emerge periodically along with time evolution. In the dissipation regime, the entanglement of the parity deformed JCM are preserved more with the increase of the deformation parameter, i.e. the stronger external field induces better degree of entanglement. PMID:27917882

International Nurse Recruitment in India

PubMed Central

Khadria, Binod

2007-01-01

Objective This paper describes the practice of international recruitment of Indian nurses in the model of a “business process outsourcing” of comprehensive training-cum-recruitment-cum-placement for popular destinations like the United Kingdom and United States through an agency system that has acquired growing intensity in India. Findings Despite the extremely low nurse to population ratio in India, hospital managers in India are not concerned about the growing exodus of nurses to other countries. In fact, they are actively joining forces with profitable commercial ventures that operate as both training and recruiting agencies. Most of this activity is concentrated in Delhi, Bangalore, and Kochi. Conclusions Gaps in data on nursing education, employment, and migration, as well as nonstandardization of definitions of “registered nurse,” impair the analysis of international migration of nurses from India, making it difficult to assess the impact of migration on vacancy rates. One thing is clear, however, the chain of commercial interests that facilitate nurse migration is increasingly well organized and profitable, making the future growth of this business a certainty. PMID:17489924

A real-time compliance mapping system using standard endoscopic surgical forceps.

PubMed

Fakhry, Morkos; Bello, Fernando; Hanna, George B

2009-04-01

In endoscopic surgery, the use of long surgical instruments through access ports diminishes tactile feedback and degrades the surgeon's ability to identify hidden tissue abnormalities. To overcome this constraint, we developed a real-time compliance mapping system that is composed of: 1) a standard surgical instrument with a high-precision sensor configuration design; 2) real-time objective interpretation of the output signals for tissue identification; and 3) a novel human-computer interaction technique using interactive voice and handle force monitoring techniques to suit operating theater working environment. The system was calibrated and used in clinical practice in four routine endoscopic human procedures. In a laboratory-based experiment to compare the tissue discriminatory power of the system with that of surgeons' hands, the system's tissue discriminatory power was three times more sensitive and 10% less specific. The data acquisition precision was tested using principal component analysis (R(2)X = 0.975, Q2 [cumulative (cum)] = 0.808 ) and partial least square discriminate analysis (R(2)X = 0.903, R(2)Y = 0.729, Q2 (cum) = 0.572).

Influence of soil-water ratio on the performance of slurry phase bioreactor treating herbicide contaminated soil.

PubMed

Venkata Mohan, S; Ramakrishna, M; Shailaja, S; Sarma, P N

2007-09-01

The influence of soil-water ratio was studied on the performance of the slurry phase bioreactor operated in sequencing batch mode (anoxic-aerobic-anoxic microenvironments) during the bioremediation of soil contaminated with pendimethalin. The performance of the reactors was evaluated at different soil-water ratios (1:5-1:25; at soil loading rate (60 kg of soil/cum-day to 12 kg of soil/cum-day)) keeping the loading rate of pendimethalin constant (133.2 g/kg of soil-day) in six reactors and variable (66.6 g/kg of soil-day to 166.6 g/kg of soil-day) in other four reactors. At 1:20 soil-water ratio, the slurry phase system showed enhanced degradation of substrate (629 microg pendimethalin/g soil). The removal efficiency of pendimethalin in the reactors was dependent on the mass-transfer rates of the substrate from the soil to the aqueous phase. Soil-water ratio and substrate loading rates showed significant influence on the substrate portioning, substrate degradation efficiency and substrate desorption rate.

Local Community Perceptions of Mine Site Restoration Using Phytoremediation in Abitibi-Temiscamingue (Quebec).

PubMed

Vodouhe, Fifanou G; Khasa, Damase P

2015-01-01

This work explores factors supporting people perception about mine site restoration and phytoremediation. Phytoremediation is one of the most eco-friendly restoration strategy emerged since the last two decades but studies on local people perception on this restoration strategy are scarce. To fill in this gap, data were collected from mining stakeholders using a structured questionnaire administered through snowball sampling method. We used Multiple Correspondence Analysis as implemented in the software XLSTAT to visualize relationship between participants' characteristics, their view on mine site restoration and phytoremediation. Results clearly show out that people perception on mine site restoration is influenced by mining activities effects on health and region attractiveness. Phytoremediation (65.21%) was rated positively with regard to its environment potential, aesthetic and consideration for future generation followed by fillings and excavating. Restoration strategy costs have no effect on people choice and participants prefer use of shrubs as vegetation component of phytoremediation to reach their restoration objective.

Inhibition of the activity of cytotoxic murine T lymphocytes by antibodies to idiotypic determinants.

PubMed Central

Rabinowitz, R; Schlesinger, M

1980-01-01

The nature of the receptors on the surface of cytotoxic T lymphocytes (CTL), which enable these cells to recognize antigens on allogeneic targets, is still a matter of controversy. In the present study various mouse alloantisera were tested for their capacity to inhibit, in the absence of complement, the cytotoxic activity of sensitized peritoneal T lymphocytes. The only antiserum which, even after heat inactivation, consistently inhibited cytotoxic T lymphocytes was an antiserum elicited in (C3H X C57B1/6)F1 mice by immunization with AKR/Cum thymus cells. The serum inhibited the cytotoxic reaction of either AKR/J or AKR/Cum CTL on EL-4 target cells but had no inhibitory activity on the cytotoxic reaction of AKR/J cells against P-815 target cells. Thus the inhibitory activity of the serum could not be attributed to antibodies against Ly-3 determinants present in the serum. This conclusion was strengthened by the finding that the inhibitory activity of the serum could be removed by absorption, not only with AKR/J thymus cells but also with AKR/J bone-marrow cells, a procedure which did not affect the titre of Ly-3 antibodies. The serum failed to exert any inhibition on cytotoxic T lymphocytes of BALB/c and C3H mice reacting against EL-4 target cells, indicating that the inhibitory activity of the antiserum did not result from contamination by antibodies against C57B1 antigenic determinants. It was concluded that the inhibitory activity of the antiserum resulted from the presence of antibodies against idiotypic determinants expressed on AKR/Cum thymus cells reacting against the hybrid hosts. It seems, therefore, that idiotypic determinants expressed on the surface of cytotoxic T lymphocytes may be directly involved in their cytotoxic activity. PMID:6155324

Threshold for onset of injury in Chinook salmon from exposure to impulsive pile driving sounds.

PubMed

Halvorsen, Michele B; Casper, Brandon M; Woodley, Christa M; Carlson, Thomas J; Popper, Arthur N

2012-01-01

The risk of effects to fishes and other aquatic life from impulsive sound produced by activities such as pile driving and seismic exploration is increasing throughout the world, particularly with the increased exploitation of oceans for energy production. At the same time, there are few data that provide insight into the effects of these sounds on fishes. The goal of this study was to provide quantitative data to define the levels of impulsive sound that could result in the onset of barotrauma to fish. A High Intensity Controlled Impedance Fluid filled wave Tube was developed that enabled laboratory simulation of high-energy impulsive sound that were characteristic of aquatic far-field, plane-wave acoustic conditions. The sounds used were based upon the impulsive sounds generated by an impact hammer striking a steel shell pile. Neutrally buoyant juvenile Chinook salmon (Oncorhynchus tshawytscha) were exposed to impulsive sounds and subsequently evaluated for barotrauma injuries. Observed injuries ranged from mild hematomas at the lowest sound exposure levels to organ hemorrhage at the highest sound exposure levels. Frequency of observed injuries were used to compute a biological response weighted index (RWI) to evaluate the physiological impact of injuries at the different exposure levels. As single strike and cumulative sound exposure levels (SEL(ss), SEL(cum) respectively) increased, RWI values increased. Based on the results, tissue damage associated with adverse physiological costs occurred when the RWI was greater than 2. In terms of sound exposure levels a RWI of 2 was achieved for 1920 strikes by 177 dB re 1 µPa(2)⋅s SEL(ss) yielding a SEL(cum) of 210 dB re 1 µPa(2)⋅s, and for 960 strikes by 180 dB re 1 µPa(2)⋅s SEL(ss) yielding a SEL(cum) of 210 dB re 1 µPa(2)⋅s. These metrics define thresholds for onset of injury in juvenile Chinook salmon.

An Integrated Strategy for Global Qualitative and Quantitative Profiling of Traditional Chinese Medicine Formulas: Baoyuan Decoction as a Case

NASA Astrophysics Data System (ADS)

Ma, Xiaoli; Guo, Xiaoyu; Song, Yuelin; Qiao, Lirui; Wang, Wenguang; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong

2016-12-01

Clarification of the chemical composition of traditional Chinese medicine formulas (TCMFs) is a challenge due to the variety of structures and the complexity of plant matrices. Herein, an integrated strategy was developed by hyphenating ultra-performance liquid chromatography (UPLC), quadrupole time-of-flight (Q-TOF), hybrid triple quadrupole-linear ion trap mass spectrometry (Qtrap-MS), and the novel post-acquisition data processing software UNIFI to achieve automatic, rapid, accurate, and comprehensive qualitative and quantitative analysis of the chemical components in TCMFs. As a proof-of-concept, the chemical profiling of Baoyuan decoction (BYD), which is an ancient TCMF that is clinically used for the treatment of coronary heart disease that consists of Ginseng Radix et Rhizoma, Astragali Radix, Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle, and Cinnamomi Cortex, was performed. As many as 236 compounds were plausibly or unambiguously identified, and 175 compounds were quantified or relatively quantified by the scheduled multiple reaction monitoring (sMRM) method. The findings demonstrate that the strategy integrating the rapidity of UNIFI software, the efficiency of UPLC, the accuracy of Q-TOF-MS, and the sensitivity and quantitation ability of Qtrap-MS provides a method for the efficient and comprehensive chemome characterization and quality control of complex TCMFs.

Regional Variations in the Prevalence of Major Congenital Malformations in Quebec: The Importance of Fetal Growth Environment.

PubMed

Zhao, Jin-Ping; Sheehy, Odile; Bérard, Anick

2015-01-01

Congenital anomalies are the consequence of a complex interaction between genetic predisposition and fetal environment. Based on the Congenital Anomalies Surveillance in Canada Report, between 1998 and 2007 the rate of congenital heart defects in Quebec was significantly higher than the Canadian average; no data on the overall prevalence of congenital anomalies for Quebec or data on regional variations in any province are available. To estimate the prevalence of major congenital malformations (MCMs) in all of the 17 administrative regions of Quebec. Using data from the Quebec Pregnancy Cohort, we included infants if they were born between January 1, 1998 and December 31, 2008. MCMs were identified within the infant's first year of life using validated ICD-9 and ICD-10 codes. The rate of MCMs was calculated and stratified on Quebec's administrative regions. Among 152,353 eligible infants, the prevalence of MCMs was 36.6 (all rates were reported as per 1,000 live births). The regions with the highest rate of MCMs were Lanaudière (48.1), Laval (45.8), and Mauricie (45.1). Regions with the lowest rate were Outaouais (13.4), Côte-Nord (19.1), Abitibi-Témiscamingue (27.5), Gaspésie-îles-de-la-Madeleine (27.9), and Saguenay-Lac-Saint-Jean (28.9). Congenital heart defects (10.3) and musculoskeletal anomalies (12.6) were the most common. Laval had the highest rate of heart defects (16.1), and Lanaudière had the highest rate of musculoskeletal anomalies (22.0). The central regions of Quebec had high rate of MCMs, whereas the relatively genetically homogenous peripheral regions of Quebec had lower rate of MCM, suggesting the importance of fetal growth environment in the etiology of MCMs in Quebec.

Fluid chemistry and evolution of hydrothermal fluids in an Archaean transcrustal fault zone network: The case of the Cadillac Tectonic Zone, Abitibi greenstone belt, Canada

USGS Publications Warehouse

Neumayr, P.; Hagemann, S.G.; Banks, D.A.; Yardley, B.W.D.; Couture, J.-F.; Landis, G.P.; Rye, R.

2007-01-01

Detailed fluid geochemistry studies on hydrothermal quartz veins from the Rouyn-Noranda and Val-d'Or areas along the transcrustal Cadillac Tectonic Zone (CTZ) indicate that unmineralized (with respect to gold) sections of the CTZ contained a distinct CO2-dominated, H2S-poor hydrothermal fluid. In contrast, both gold mineralized sections of the CTZ (e.g., at Orenada #2) and associated higher order shear zones have a H2O-CO2 ?? CH4-NaCl hydrothermal fluid. Their CO2/H2S ratios indicate H2S-rich compositions. The Br/Cl compositions in fluid inclusions trapped in these veins indicate that hydrothermal fluids have been equilibrated with the crust. Oxygen isotope ratios from hydrothermal quartz veins in the CTZ are consistently 2??? more enriched than those of associated higher order shear zones, which are interpreted to be a function of greater fluid/rock ratios in the CTZ and lower fluid/rock ratios, and more efficient equilibration of the hydrothermal fluid with the wall rock, in higher order shear zones. An implication from this study is that the lower metal endowment of the transcrustal CTZ, when compared with the higher metal endowment in higher order shear zones (ratio of about 1 : 1000), may be the result of the lack of significant amounts of H2O-H2S rich fluids in most of the CTZ. In contrast, gold mineralization in the higher order shear zones appear to be controlled by the high H2S activity of the aqueous fluids, because gold was likely transported in a bisulfide complex and was deposited during sulfidation reactions in the wall rock and phase separation in the quartz veins. ?? 2007 NRC Canada.

Official opening remarks: Manitoba natural resources

Treesearch

Merlin W. Shoesmith

1997-01-01

Mr. Chairman, distinguished guests, owl biologists, ladies and gentlemen. I am very pleased to be with you today to officially open the Second International Symposium on the Biology and Conservation of Owls. I welcome you to Manitoba and bring greetings on behalf of our Premier, Gary Filmon, and the Honorable Glen Cummings, Minister of Natural Resources. As well, a...

The College Experiences of International Black Women in the United States: A Caribbean Perspective

ERIC Educational Resources Information Center

Talley Matthews, Sheikia T.

2017-01-01

Institutions of higher education in the United States enroll the largest number of international students in the world each year (Bain & Cummings, 2005). In 2014-2015, the United States hosted 974,926 international students from around the globe (Open Doors, 2016). The number of students attending college in the United States from Latin…

Megabytes and Colour, but Learning Is Still the Issue

ERIC Educational Resources Information Center

Cumming, Geoff

2005-01-01

In the first issue of "Australian Educational Computing," in 1986, Cumming and Abbott reported a controlled comparison of top-down and bottom-up teaching strategies for Grade 5 and 6 students' use of a simple logic programming language. They found that both strategies were rated highly by students and teachers, and gave useful learning;…

Re-inventing the Historical in Comparative Education: Reflections on a Protean Episteme by a Contemporary Player.

ERIC Educational Resources Information Center

Kazamias, Andreas M.

2001-01-01

Since the 1960s, the epistemological-cum-methodological orientations of American and British comparative education changed from being historical to being social scientific. This metamorphosis has impoverished the field, and a return to a re-invented historical mode of comparative analysis would help to humanize comparative education in a cosmos of…

Atomic Dipole Squeezing in the Correlated Two-Mode Two-Photon Jaynes-Cummings Model

NASA Technical Reports Server (NTRS)

Dong, Zhengchao; Zhao, Yonglin

1996-01-01

In this paper, we study the atomic dipole squeezing in the correlated two-mode two-photon JC model with the field initially in the correlated two-mode SU(1,1) coherent state. The effects of detuning, field intensity and number difference between the two field modes are investigated through numerical calculation.

Is "In Consortio Cum Parentibus" the New "In Loco Parentis?"

ERIC Educational Resources Information Center

Henning, Gavin

2007-01-01

"In loco parentis" had been the philosophical foundation of higher education policy and practice since 1913 when it was established as a legal doctrine in Gott v. Berea. The doctrine defined the relationship between colleges, students, and parents. That relationship has changed with the death of "in loco parentis" in Dixon v. Alabama Board of…

Web Connects K-12 Students with Scientists

ERIC Educational Resources Information Center

Cavanagh, Sean

2009-01-01

This article reports that Derek Cummings and Justin Lessler, Johns Hopkins University epidemiologists, have come to the Johns Hopkins Center for Talented Youth (CTY) to give a live webinar on the spread of swine flu. This web-based audio and video presentation is one of many efforts by universities and science organizations to put K-12 students in…

Governing the Social, Material, Textual, and Advancing Professional Learning of Doctoral Candidates in the Contemporary University

ERIC Educational Resources Information Center

Manidis, Marie; Goldsmith, Rosalie

2018-01-01

Doctoral education is increasingly of interest to higher education researchers and policy-makers as the qualification's diversity, governance, reach and policy outcomes come under growing scrutiny. In the context of these changes, the paper adopts for the first time since Cumming's seminal study, a practice-based exploration of the social,…

Microstrucutral Modeling of Hot Spot and Failure Mechanisms in RDX Energetic Aggregates

DTIC Science & Technology

2014-01-01

with applications to disposable blood pressure cuffs . He graduated cum laude with a Bachelors of Science degree in Mechanical Engineering in May of...35 Figure 4.2. (a) Rotation , (b) Normal Stress, (c) Pressure, and (d...39 Figure 4.6. (a) Rotation , (b) Normal Stress, (c) Pressure, and (d) Accumulated plastic shear

Assessing urban forest structure: summary and conclusions

Treesearch

David J. Nowak

2008-01-01

This special issue has presented data on several topics related to assessing urban forest structure. These topics include means to measure urban forest cover from aerial-based platforms (Walton et al. 2008), national and local ground-based assessments of urban forest structure and functions (Cumming et al. 2008; Nowak et al. 2008a), measurement of street tree...

Maternal Warmth and Early Adolescents' Internalizing Symptoms and Externalizing Behavior: Mediation via Emotional Insecurity

ERIC Educational Resources Information Center

Alegre, Albert; Benson, Mark J.; Pérez-Escoda, Núria

2014-01-01

This study examines the relation between maternal warmth and the internalizing and externalizing problems of early adolescents, and the potential mediation of this relation by emotional insecurity. The hypotheses for the study derive from Cummings and Davies' theory of emotional security. The current study extends the theory to security processes…

Using Parent Book Clubs to Build a School-Wide Reading Community

ERIC Educational Resources Information Center

Deuschle, Kristen

2017-01-01

A prevalent misconception is that reading must be a solitary endeavor. This view of reading creates an instant aversion for many teens who tend to be social creatures. This article discusses how Kristen Deuschle, the district media specialist for Forsyth County Schools in Cumming, Georgia, combined two of her passions--community outreach and…

University Study Licenses and Clerical Education in the Diocese of Norwich, 1325-35.

ERIC Educational Resources Information Center

Shinners, John R., Jr.

1988-01-01

Assesses the strengths and weaknesses of university study licenses such as the "Licet canon" and the "Cum ex eo" which, when issued by the Vatican in the 13th century, allowed unordained parochial rectors and ordained priests to obtain higher education. Concludes that study licenses improved the education of the parochial…

Drama Queen or Trauma Queen: Does Elevating Self-Awareness Impact the Colonized Consciousness of Female Clergy?

ERIC Educational Resources Information Center

Clifton, Angelita

2013-01-01

This project design incorporates three Aramaic phrases enhancing an existing ministry model for women victimized by trauma. "Talitha Cum-Woman Arise," "Ephpatha-Be Opened" and "Maranatha-O'Lord Come," serve as the foundation for a three tiered spiritual support system for female clergy. This project design serves: (1)…

Normal D-Region Models for Weapon Effects Code

DTIC Science & Technology

1985-09-18

ATTN: DNA REP) ATTN: DRSMI-YSO J GAMBLE ATTN: JLKS ATTN: JPTM US ARMY WHITE SANDS MISSILE RANGE ATTN: JPTP ATTN: STEWS -TE-N K CUMMINGS NATIONAL SECURITY... LAMB ATTN: G SMITH ATTN: F GILMORE ATTN: J VICKREY ATTN: M GANTSWEG ATTN: R LEADABRAND ATTN: W KARZAS ATTN: R TSUNODA ATTN: W CHESNUT a R & D ASSOCIATES

The Application of Statistical Turbulence Theory to Convective Instabilities.

DTIC Science & Technology

1986-11-01

WHITE SANDS MISSILE RANGE DEPARTMENT OF THE AIR FORCE ATTN: STEWS -TE-N K CUMMINGS AIR FORCE CTR FOR STUDIES & ANALYSIS DEPARTMENT OF THE NAVY ATTN...INC ATTN: R BUCKNER ATTN: J DEVORE " ATTN: J THOMPSON TOYON RESEARCH CORP ATTN: W SCHLUETER ATTN: J GARBARINO ATTN: J ISE R & D ASSOCIATES ATTN: B LAMB

Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

ERIC Educational Resources Information Center

Morales, Marie Paz E.

2016-01-01

This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

Heterobimetallic Dioxygen Activation

PubMed Central

York, John T.; Llobet, Antoni; Cramer, Christopher J.; Tolman, William B.

2008-01-01

Heterobimetallic CuPd and CuPt bis(μ-oxo) complexes have been prepared by the reaction of (PPh3)2MO2 (M = Pd, Pt) with LCu(I) precursors (L = β-diketiminate and di- and triamine ligands) and characterized by low-temperature UV-vis, resonance Raman, and 1H and 31P{1H} NMR spectroscopy in conjunction with DFT calculations. The complexes decompose upon warming to yield OPPh3, and in one case this was shown to occur by an intramolecular process through crossover experiments using double-labeling (oxo and phosphine). The reactivity of one of the complexes, LMe2Cu(μ-O)2Pt(PPh3)2 (LMe2 = β-diketiminate), with a variety of reagents including CO2, 2,4-di-tert-butylphenol, 2,4-di-tert-butylphenolate, [NH4][PF6], and dihydroanthracene, was compared to that of homometallic Pt2 and Cu2 counterparts. Unlike typical [Cu2(μ-O)2]2+ cores which have electrophilic oxo groups, the oxo groups in the [Cu(μ-O)2Pt]+ core behave as bases and nucleophiles, similar to previously described Pt2 compounds. In addition, however, the [Cu(μ-O)2Pt]+ core is capable of oxidatively coupling 2,4-di-tert-butylphenol and 2,4-di-tert-butylphenolate. Theoretical evaluation of the electron affinities, basicities, and H-atom transfer kinetics and thermodynamics of the Cu2 and CuM (M = Pd, Pt) cores showed that the latter are more basic and form stronger O-H bonds. PMID:17550254

Tracing sources of crustal contamination using multiple S and Fe isotopes in the Hart komatiite-associated Ni-Cu-PGE sulfide deposit, Abitibi greenstone belt, Ontario, Canada

NASA Astrophysics Data System (ADS)

Hiebert, R. S.; Bekker, A.; Houlé, M. G.; Wing, B. A.; Rouxel, O. J.

2016-10-01

Assimilation by mafic to ultramafic magmas of sulfur-bearing country rocks is considered an important contributing factor to reach sulfide saturation and form magmatic Ni-Cu-platinum group element (PGE) sulfide deposits. Sulfur-bearing sedimentary rocks in the Archean are generally characterized by mass-independent fractionation of sulfur isotopes that is a result of atmospheric photochemical reactions, which produces isotopically distinct pools of sulfur. Likewise, low-temperature processing of iron, through biological and abiotic redox cycling, produces a range of Fe isotope values in Archean sedimentary rocks that is distinct from the range of the mantle and magmatic Fe isotope values. Both of these signals can be used to identify potential country rock assimilants and their contribution to magmatic sulfide deposits. We use multiple S and Fe isotopes to characterize the composition of the potential iron and sulfur sources for the sulfide liquids that formed the Hart deposit in the Shaw Dome area within the Abitibi greenstone belt in Ontario (Canada). The Hart deposit is composed of two zones with komatiite-associated Ni-Cu-PGE mineralization; the main zone consists of a massive sulfide deposit at the base of the basal flow in the komatiite sequence, whereas the eastern extension consists of a semi-massive sulfide zone located 12 to 25 m above the base of the second flow in the komatiite sequence. Low δ56Fe values and non-zero δ34S and Δ33S values of the komatiitic rocks and associated mineralization at the Hart deposit is best explained by mixing and isotope exchange with crustal materials, such as exhalite and graphitic argillite, rather than intrinsic fractionation within the komatiite. This approach allows tracing the extent of crustal contamination away from the deposit and the degree of mixing between the sulfide and komatiite melts. The exhalite and graphitic argillite were the dominant contaminants for the main zone of mineralization and the eastern extension zone of the Hart deposit, respectively. Critically, the extent of contamination, as revealed by multiple S and Fe isotope systematics, is greatest within the deposit and decreases away from it within the komatiite flow. This pattern points to a local source of crustal contamination for the mantle-derived komatiitic melt and a low degree of homogenization between the mineralization and the surrounding lava flow. Coupled S and Fe isotope patterns like those identified at the Hart deposit may provide a useful tool for assessing the potential of a komatiitic sequence to host Ni-Cu-(PGE).

Leadership Aspects of Hidden Curriculum Students Practice in Nigerian Universities: A Preview of Students' Union Government Contributions in University Governance

ERIC Educational Resources Information Center

Emesini, Nnenna Orieoma

2016-01-01

The paper examined the leadership aspect of Hidden Curriculum that students practice in Nigerian Universities and their contributions to university governance. Four research questions guided the study and Ex-Post-Facto Method was adopted as the design. Unstructured interviews with staff/students officials cum critical analysis of Students' Union…

Information Management for an Automated Battlefield Command and Control System

DTIC Science & Technology

1980-05-01

DD) I u FJ i EDITION OF" I NOV 65, IS OSSOLIETIES"-- iUnclassified1SECURITY CLASSIFICATION OF THIS PAGE (When Data Entered) t// II. Unclassified...DIRELIOk oý INSTIhJTIONAL RSCH I USA AIP DEFENSE SCHOUL ATTN: AISA -CU)-MS I iJSAADS-LIBRARY-OUCUMLNTS) I USA AIW DEFENSE ZL~N HDAU IN: fILLS

Information and Communications Technology (ICT) and the Seduction of Knowledge, Teaching, and Learning: What Lies Ahead for Education

ERIC Educational Resources Information Center

Kompf, Michael

2005-01-01

This review essay cum discussion paper outlines areas of concern with the underlying terms and conditions of the use of information and communications technology (ICT) in education. The books that instigated this foray ( Barrell, 2001; Cuban, 2001; Maeroff, 2003) are representative of the field and represent inquiry and opinion that reflect…

Oral Contraceptives and Bone Health in Female Runners

DTIC Science & Technology

2006-10-01

activity. Previous cross-sectional research has shown that women with exercise - induced menstrual irregularities have a significantly higher...6. Cumming D.C. Exercise -associated amenorrhea , low BMD, and estrogen replacement therapy. Arch Intern Med. 156:2193-2195, 1996. 34 7. De...Science in Sports & Exercise . (i) Abstract from manuscript, “Randomized trial of the effect of oral contraceptives on bone mass and stress

Tracks in the Sand: Hooke's Pendulum "Cum Grano Salis"

ERIC Educational Resources Information Center

Babovic, Vukota; Babovic, Miloš

2014-01-01

The history of science remembers more than just formal facts about scientific discoveries. These side stories are often inspiring. One of them, the story of an unfulfilled death wish of Jacob Bernoulli regarding spirals, inspired us to look around ourselves. And we saw natural spirals around us, which led to the creation of a Hooke's…

Biological Response to the Dynamic Spectral-Polarized Underwater Light Field

DTIC Science & Technology

2011-09-30

www.bio.utexas.edu/research/cummingslab/ LONG-TERM GOALS Camouflage in marine environments requires matching all of the background optical ...polarized light field in near-shore and near-surface environments (2) Characterize the biological camouflage response of organisms to these dynamic optical ...field will be measured by the simultaneous deployment of a comprehensive optical suite including underwater video-polarimetry (Cummings), inherent

Military Wife Adjustment, An Independent Dependent

DTIC Science & Technology

1981-01-01

managing family responsibilities alone (Mc:Cubbin, 1978; McCubbin, et al., 1980; Rienerth, 1978). Wives utLlized various coping strategies during the...stiff upper lip." The family becomes matricentric, and the military mother becomes domestic manager in complete charge of all familial ...Highway University of Maryland ZIi K Arlington VA 22202 College of Business and Management . . ,and Department of Psychology Dr. Lartry-:..Cummings

Design and Study of a Low-Cost Laboratory Model Digital Wind Power Meter

ERIC Educational Resources Information Center

Radhakrishnan, Rugmini; Karthika, S.

2010-01-01

A vane-type low-cost laboratory model anemometer cum power meter is designed and constructed for measuring low wind energy created from accelerating fluids. The constructed anemometer is a device which records the electrical power obtained by the conversion of wind power using a wind sensor coupled to a DC motor. It is designed for its…

Further tests of entreaties to avoid hypothetical bias in referendum contingent valuation

Treesearch

Thomas C. Brown; Icek Ajzen; Daniel Hrubes

2003-01-01

Over-estimation of willingness to pay in contingent markets has been attributed largely to hypothetical bias. One promising approach for avoiding hypothetical bias is to tell respondents enough about such bias that they self-correct for it. A script designed for this purpose by Cummings and Taylor was used in hypothetical referenda that differed in payment amount. In...

EFFECTS OF 20 WEEK EXPOSURES IN FEMALE SPRAGUE-DAWLEY (S-D) RATS TO DIBROMOACETIC ACID, A DRINKING WATER DISINFECTANT BY-PRODUCT

EPA Science Inventory

Effects of 20 week exposures in female Sprague-Dawley (S-D) rats to the drinking water disinfection by-product dibromoacetic acid. A S Murr and J M Goldman, Endocrinol. Br., RTD, NHEERL, ORD, US EPA, Res. Tri. Pk, NC. Sponsor: Audrey Cummings

The drinking water disinfect...

EFFECTS OF 20 WEEK EXPOSURES IN FEMALE SPRAGUE-DAWLEY (S-D) RATS TO THE DRINKING WATER DISINFECTION BY-PRODUCT DIBROMOACETIC ACID

EPA Science Inventory

Effects of 20 week exposures in female Sprague-Dawley (S-D) rats to the drinking water disinfection by-product dibromoacetic acid. A S Murr and J M Goldman, Endocrinol. Br., RTD, NHEERL, ORD, US EPA, Res. Tri. Pk, NC. Sponsor: Audrey Cummings

The drinking water disinfect...

Quantum speed limit for arbitrary initial states

PubMed Central

Zhang, Ying-Jie; Han, Wei; Xia, Yun-Jie; Cao, Jun-Peng; Fan, Heng

2014-01-01

The minimal time a system needs to evolve from an initial state to its one orthogonal state is defined as the quantum speed limit time, which can be used to characterize the maximal speed of evolution of a quantum system. This is a fundamental question of quantum physics. We investigate the generic bound on the minimal evolution time of the open dynamical quantum system. This quantum speed limit time is applicable to both mixed and pure initial states. We then apply this result to the damped Jaynes-Cummings model and the Ohimc-like dephasing model starting from a general time-evolution state. The bound of this time-dependent state at any point in time can be found. For the damped Jaynes-Cummings model, when the system starts from the excited state, the corresponding bound first decreases and then increases in the Markovian dynamics. While in the non-Markovian regime, the speed limit time shows an interesting periodic oscillatory behavior. For the case of Ohimc-like dephasing model, this bound would be gradually trapped to a fixed value. In addition, the roles of the relativistic effects on the speed limit time for the observer in non-inertial frames are discussed. PMID:24809395

Dendritic Spines in Depression: What We Learned from Animal Models

PubMed Central

Qiao, Hui; Li, Ming-Xing; Xu, Chang; Chen, Hui-Bin; An, Shu-Cheng; Ma, Xin-Ming

2016-01-01

Depression, a severe psychiatric disorder, has been studied for decades, but the underlying mechanisms still remain largely unknown. Depression is closely associated with alterations in dendritic spine morphology and spine density. Therefore, understanding dendritic spines is vital for uncovering the mechanisms underlying depression. Several chronic stress models, including chronic restraint stress (CRS), chronic unpredictable mild stress (CUMS), and chronic social defeat stress (CSDS), have been used to recapitulate depression-like behaviors in rodents and study the underlying mechanisms. In comparison with CRS, CUMS overcomes the stress habituation and has been widely used to model depression-like behaviors. CSDS is one of the most frequently used models for depression, but it is limited to the study of male mice. Generally, chronic stress causes dendritic atrophy and spine loss in the neurons of the hippocampus and prefrontal cortex. Meanwhile, neurons of the amygdala and nucleus accumbens exhibit an increase in spine density. These alterations induced by chronic stress are often accompanied by depression-like behaviors. However, the underlying mechanisms are poorly understood. This review summarizes our current understanding of the chronic stress-induced remodeling of dendritic spines in the hippocampus, prefrontal cortex, orbitofrontal cortex, amygdala, and nucleus accumbens and also discusses the putative underlying mechanisms. PMID:26881133

Synthesis of graphene oxide-copper molybdate (GO-CuM) nanocomposites for photocatalytic application

NASA Astrophysics Data System (ADS)

Singh, Gajendar; Bhargava, V. Sai; Sharma, Manu

2018-05-01

Transition metal molybdates (TMBs) MMoO4 (M=Ni, Cu, Fe, Zn, Co, etc.) based nanocomposites have been considered as remarkable materials in the field of electronics, optics, catalysis, supercapicitors and energy storage devices. Nanocomposites of TMBs with graphene oxide have also been chosen as an effective material in photocatalytic application. GO-CuM nanocomposites were synthesized by ultra-sonication method at RT, followed by reflux route for preparation of CuM and GO by modified Hemmer's method. As prepared nanocomposites were characterized using analytical techniques such as PXRD, SEM, FT-IR and UV-Visible spectroscopy. The enhanced photocatalytic activity of Methylene blue (MB) dye was observed by GO-CuM nanocomposites as compared to pure copper molybdate. GO-CuM nanocomposites show high photodegradation rate (0.094 min-1) whereas CuM was degraded only 30 % with the rate of 0.0029 min-1. The high photocatalytic efficiency is due to the presence of graphene oxide that helps to delay the charge recombination in photocatalytic reaction The effect of the different amount of graphene oxide on the photocatalytic activity of as prepared photocatalyst has also been investigated.

Rapid characterization of the chemical constituents of Sijunzi decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry.

PubMed

Guan, Zhibo; Wang, Miao; Cai, Yi; Yang, Hongmei; Zhao, Min; Zhao, Chunjie

2018-06-01

Sijunzi decoction, a renowned Chinese prescription has long been utilized to treat gastrointestinal problems. In the context of this research work, the use of Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry was made to separate and characterize the components of Sijunzi decoction. The performance of Liquid chromatography was carried out on a C8 column (150 mm × 2.1 mm, 1.8 μm); moreover, the mobile phase were consisted of 0.2% formic acid (A) and acetonitrile (B). In accordance with the findings, characterization of 120 chemical compounds was performed by liquid chromatography with mass spectrometry. The key constituents among them included ginsenosides (in Radix Ginseng), 16 triterpene carboxylic acids (in Poria), sesquiterpenes (in Rhizoma Atractylodis Macrocephalae), triterpenesaponins (in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) as well as flavonoids (in Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) in Sijunzi decoction. This research developed the bases for prospective research associated with Sijunzi decoction, together with being expected to be useful to rapidly extract and characterize the constituents in other Traditional Chinese herbal formulations. Copyright © 2018 Elsevier B.V. All rights reserved.

3,5,6,7,8,3′,4′-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation

PubMed Central

Sawamoto, Atsushi; Okuyama, Satoshi; Amakura, Yoshiaki; Yoshimura, Morio; Yamada, Takashi; Yokogoshi, Hidehiko; Nakajima, Mitsunari

2017-01-01

We previously reported that the subcutaneous administration of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), a citrus polymethoxyflavone, attenuated depressive-like behavior and increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a corticosterone-induced depression-like mouse model. We herein demonstrated that (1) HMF was detectable in the brain 10 and 30 min after its oral administration, (2) orally administered HMF improved chronic unpredictable mild stress (CUMS)-induced pathological conditions, including body weight loss and depressive-like behavior, and CUMS-induced neurochemical changes, such as reduction in BDNF expression, decrease in neurogenesis, and decreased level of phosphorylated calcium-calmodulin-dependent protein kinase II in the hippocampus, and (3) these effects of HMF were inhibited by the pre-administration of U0126, a mitogen-activated protein (MAP) kinase inhibitor. These results suggest that orally administered HMF is beneficial for the upregulation of BDNF in the hippocampus via the extracellular signal-regulated kinase1/2 (ERK1/2)/MAP system, which may account for its antidepression effects. PMID:29023414

Biological Response to the Dynamic Spectral-Polarized Underwater Light Field

DTIC Science & Technology

2012-09-30

deployment of a comprehensive optical suite including underwater video- polarimetry (full Stokes vector video-imaging camera custom-built Cummings; and...During field operations, we couple polarimetry measurements of live, free-swimming animals in their environments with a full suite of optical...Seibel, Ahmed). We also restrain live, awake animals to take polarimetry measurements (in the field and laboratory) under a complete set of

Near East/South Asia Report.

DTIC Science & Technology

1987-01-20

sheep pox vac- cines, artificial insemination , soil testing and others. In the meantime, the Soviet scientists introduced the Soviet sunflower into...voltage po- wer transmission line fr- om the Soviet Union to northern regions of the : DRA, the earth satellite ; link station, road-cum-rail...ISRO in making and sup- plying "vital and sensitive" electronic items re- quired by ISRO for remote sensing satellites , augmented satellite

Center for Opto-Electronic Systems Research.

DTIC Science & Technology

1988-02-01

Stroud, Jr. The Institute of Optics, University of Rochester Rochester, New York 14627 USA Abstract The Jaynes - Cummings model of a single two-level...surfaces, possibly to include certain classes of surfaces without rotational symmetry. An initial investigation was made of the surface roughness...number density of approximately 1018 - and the forward-going pump wave both enter the nonlinear -.molecules/cm3 . The intensities of the interacting

SGR 1822-1606: Constant Spin Period

NASA Astrophysics Data System (ADS)

Serim, M.; Baykal, A.; Inam, S. C.

2011-08-01

We have analyzed light curve of the new source SGR 1822-1606 (Cummings et al. GCN 12159) using the real time data of RXTE observations. We have extracted light curve for 11 pointings with a time span of about 20 days and employed pulse timing analysis using the harmonic representation of pulses. Using the cross correlation of harmonic representation of pulses, we have obtained pulse arrival times.

50 years of optics research [Invited].

PubMed

Schwider, Johannes

2013-01-01

The 50-year life span of Applied Optics covers also approximately the time I have been engaged in optics. I started in 1962 [1] with the Institute for Optics and Spectroscopy, which was one of several Academy Institutes (mission statement: "theoria cum praxi," G. Leibniz) located in Berlin-Adlershof on the area of the first airfield in Berlin dating back to the beginning of the 20th century.

Evaluation of Management Systems Performance at Navy Regional Data Automation Centers.

DTIC Science & Technology

1984-03-01

REPORT NUMBER 7 . AUTHN~s) S. CONTRACT OR GRANT NUM@ER(@) Gloria Jean Cummings Scott 9. PERFORMING OROANIZATION NAME AND ADDRESS 10. PROGR3AM1 ELEMENT...120 BIBLIOGRAPHY . .. .. .. .. ... . . . . .. ... 124 I INITIAl DISTRIBUTION LIST ............... 125 7 p I,, 7 7 t I...invest- ment in information resources-- people , machines, and technologies. Unit costs of hardware continue to decline [Ref. 1]. Because computer needs

Implications for Advanced Nursing Practice in the Patient with Heat Stress

DTIC Science & Technology

1993-05-01

sweating and evaporative cooling potential. Diabetic patients are at increased risk for circo.iatory disorders and neiiropathies, whiPh Heat 10 can... Diabetics are often afflicted with cardiovascular disease and peripheral neuropathy, while conditions of abnormal skin or sweat glands interfere with...of cell damage throughout the body (Cummings). Hyperkalemia from rhabdomyolysis, renal failure and/or metabolic acidosis can be life- threatening

Use of Respirometry To Determine the Effect of Nutrient Enhancement on JP-8 Biodegradability.

DTIC Science & Technology

1995-11-27

present, environmental conditions, and certainly indigenous microbial communities present ( Atlas and Bartha , 1993). In general, biodegradation can be...Richard Bartha . Microbial Ecology : Fundementals and Applications. Redwood City, CA: The Benjamin Cummings Publishing Company, Inc, 1993. Autry...products caused by microorganisms or their enzymes ( Atlas and Bartha , 1993). It is greatly influenced by the nature and amount of the target compound

[Policy recommendations based on SWOT analysis for agricultural industrialization of traditional Chinese medicinal materials--a case study of uncariae ramulus cum uncis from Jianhe county in Guizhou province].

PubMed

Hu, Yong; Huo, Ke-Yi; Xiang, Hua

2013-09-01

This thesis reviews the historical background of agricultural industrialization, and analyzes the major theories of agricultural industrialization. It also utilizes SWOT analysis method to discuss the industrialization of traditional Chinese medicinal materials in Jianhe county, and finally it puts forward the recommendations for its further development.

40 CFR 91.508 - Cumulative Sum (CumSum) procedure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... family may be determined to be in noncompliance for purposes of § 91.510. H = The Action Limit. It is 5.0 × σ, and is a function of the standard deviation, σ. σ = is the sample standard deviation and is... Equation must be final deteriorated test results as defined in § 91.509(c). Ci = max[0 0R (Ci-1 + Xi − (FEL...

ILO/KRIVET National Tripartite Workshop: Workplace Learning in a Globalizing World [Proceedings] (Seoul, South Korea, November 29-30, 2001).

ERIC Educational Resources Information Center

Korea Research Inst. for Vocational Education and Training, Seoul.

This document contains the following five papers, all in both English and Korean, from a workshop on on-the-job training held in Korea in 2001: "Issues in Knowledge and Skills Development: Globalization and the Effective Use of New Technologies" (S. Ian Cummings); "The Knowledge Economy and Vocational Training Policy in Korea"…

What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

ERIC Educational Resources Information Center

Michael, Kurt D.

2006-01-01

Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

Sub-poissonian photon statistics in the coherent state Jaynes-Cummings model in non-resonance

NASA Astrophysics Data System (ADS)

Zhang, Jia-tai; Fan, An-fu

1992-03-01

We study a model with a two-level atom (TLA) non-resonance interacting with a single-mode quantized cavity field (QCF). The photon number probability function, the mean photon number and Mandel's fluctuation parameter are calculated. The sub-Poissonian distributions of the photon statistics are obtained in non-resonance interaction. This statistical properties are strongly dependent on the detuning parameters.

Students' Perceptions of the Usefulness of an E-Book with Annotative and Sharing Capabilities as a Tool for Learning: A Case Study

ERIC Educational Resources Information Center

Lim, Ee-Lon; Hew, Khe Foon

2014-01-01

E-books offer a range of benefits to both educators and students, including ease of accessibility and searching capabilities. However, the majority of current e-books are repository-cum-delivery platforms of textual information. Hitherto, there is a lack of empirical research that examines e-books with annotative and sharing capabilities. This…

MASTER Optical Flare Detection from the Fastes Accretor in Our Galaxy - IGR J00291+5934.

NASA Astrophysics Data System (ADS)

Lipunov, V.; Rebolo, R.; Serra-Ricart, M.; Lodieu, N.; Israelian, G.; Lipunov, V.; Gorbovskoy, E.; Kornilov, V.; Balanutsa, P.; Tiurina, N.; Kuznetsov, A.; Chazov, V.; Vlasenko, D.; Gorbunov, I.; Buckley, D.; Potter, S.; Kotze, M.; Gress, O.; Budnev, N. M.; Ivanov, K.; Tlatov, A.; Dormidontov, D.; Senik, V.; Parhomenko, A. V.; Krushinski, V.; Zalozhnykh, I.; Sergienko, Yu.; Gabovich, A.; Yurkov, V.

2015-07-01

MASTER II robotic telescope (MASTER-Net: http://observ.pereplet.ru, Lipunov et al., Advances in Astronomy, MASTER Global Robotic Net, 2010) located in IAC was pointed to the Swift IGR J00291+5934 (Cummings et al., GCN 18051) 24 sec after notice time and 1103 sec after trigger time at 2015-07-24 05:42:03 UT.

Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model.

PubMed

Song, Wu; Guo, Yan; Jiang, Shuang; Wei, Lin; Liu, Zhi; Wang, Xiaoyan; Su, Ying

2018-05-22

Depression is a major social and health problem worldwide. Compound K (CK), an intestinal metabolite of panaxadiol ginsenosides, has been demonstrated to possess significant pharmacological effects on the central nervous system (CNS). Here, we set up this study to investigate the antidepressant effect of CK, and to explore the potential mechanisms underlying this activity. The behavioral despair model and chronic unpredictable mild stress (CUMS) model were established in mice or rats, respectively. Forced swimming test (FST), tail suspension test (TST) and locomotor activity were performed in mice, while the open-field test, food consumption and sucrose preference were assessed in rats. To investigate the underlying mechanism, the levels of endogenous noradrenaline, dopamine (DA), 5-hydroxytryptamine (5-HT) and their metabolites in the prefrontal cortex (PFC) and hippocampus were detected by HPLC coupled with electron detector. The dopamine degradation enzyme (COMT and MAO) expression was measured by western blot. The BDNF and NGF expression were investigated by immunohistochemical staining analysis. The results showed CK (10, 30 mg/kg) intragastric administration for 14 days significantly shorten the immobility time in FST and TST, which could be partially reversed by a D1 receptor antagonist Sch23390. For CUMS rats, CK alleviated the depressant-like behaviors, including decreased food consumption, spontaneous locomotor activity and lower sucrose preference, while WAY-100635, a 5-HT 1A receptor antagonist, could attenuate this effect. In addition, CK increased the levels of 5-HT, DA and their metabolites in the PFC and hippocampus of CUMS rats, and could reverse overexpression of MAO B in PFC and hippocampus. CK also increased the GSH and GPx activity in the hippocampus and PFC. The IHC results revealed the BDNF and NGF expression were increased in CK-treated rats. The obtained results indicate that CK exhibits antidepressant effects in rodents, which may be due to the regulation of monoamine neurotransmitter concentration, enhancement of antioxidant capacity, as well as increase of neurotrophin expression in the CNS.

Effect of metal ions on the reactions of the cumyloxyl radical with hydrogen atom donors. Fine control on hydrogen abstraction reactivity determined by Lewis acid-base interactions.

PubMed

Salamone, Michela; Mangiacapra, Livia; DiLabio, Gino A; Bietti, Massimo

2013-01-09

A time-resolved kinetic study on the effect of metal ions (M(n+)) on hydrogen abstraction reactions from C-H donor substrates by the cumyloxyl radical (CumO(•)) was carried out in acetonitrile. Metal salt addition was observed to increase the CumO(•) β-scission rate constant in the order Li(+) > Mg(2+) > Na(+). These effects were explained in terms of the stabilization of the β-scission transition state determined by Lewis acid-base interactions between M(n+) and the radical. When hydrogen abstraction from 1,4-cyclohexadiene was studied in the presence of LiClO(4) and Mg(ClO(4))(2), a slight increase in rate constant (k(H)) was observed indicating that interaction between M(n+) and CumO(•) can also influence, although to a limited extent, the hydrogen abstraction reactivity of alkoxyl radicals. With Lewis basic C-H donors such as THF and tertiary amines, a decrease in k(H) with increasing Lewis acidity of M(n+) was observed (k(H)(MeCN) > k(H)(Li(+)) > k(H)(Mg(2+))). This behavior was explained in terms of the stronger Lewis acid-base interaction of M(n+) with the substrate as compared to the radical. This interaction reduces the degree of overlap between the α-C-H σ* orbital and a heteroatom lone-pair, increasing the C-H BDE and destabilizing the carbon centered radical formed after abstraction. With tertiary amines, a >2-order of magnitude decrease in k(H) was measured after Mg(ClO(4))(2) addition up to a 1.5:1 amine/Mg(ClO(4))(2) ratio. At higher amine concentrations, very similar k(H) values were measured with and without Mg(ClO(4))(2). These results clearly show that with strong Lewis basic substrates variations in the nature and concentration of M(n+) can dramatically influence k(H), allowing for a fine control of the substrate hydrogen atom donor ability, thus providing a convenient method for C-H deactivation. The implications and generality of these findings are discussed.

Selective Production of 2-Methylfuran by Gas-Phase Hydrogenation of Furfural on Copper Incorporated by Complexation in Mesoporous Silica Catalysts.

PubMed

Jiménez-Gómez, Carmen Pilar; Cecilia, Juan A; Moreno-Tost, Ramón; Maireles-Torres, Pedro

2017-04-10

Copper species have been incorporated in mesoporous silica (MS) through complexation with the amine groups of dodecylamine, which was used as a structure-directing agent in the synthesis. A series of Cu/SiO 2 catalysts (xCu-MS) with copper loadings (x) from 2.5 to 20 wt % was synthesized and evaluated in the gas-phase hydrogenation of furfural (FUR). The most suitable catalytic performance in terms of 2-methylfuran yield was obtained with an intermediate copper content (10 wt %). This 10Cu-MS catalyst exhibits a 2-methylfuran yield higher than 95 mol % after 5 h time-on-stream (TOS) at a reaction temperature of 210 °C with a H 2 /FUR molar ratio of 11.5 and a weight hourly space velocity (WHSV) of 1.5 h -1 . After 14 h TOS, this catalyst still showed a yield of 80 mol %. In all cases, carbonaceous deposits on the external surface were the cause of the catalyst deactivation, although sintering of the copper particles was observed for higher copper loadings. This intermediate copper loading (10 wt %) offered a suitable balance between resistance to sintering and tendency to form carbonaceous deposits. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Variational Data Assimilation for the Global Ocean

DTIC Science & Technology

2013-01-01

ocean includes the Geoid (a fixed gravity equipotential surface ) as well as the MDT, which is not known accurately enough relative to the centimeter...scales, including processes that control the surface mixed layer, the formation of ocean eddies, meandering ocean J.A. Cummings (E3) nography Division...variables. Examples of this in the ocean are integral quantities, such as acous^B travel time and altimeter measures of sea surface height, and direct

A Comparative Study of Academic Staff Teaching Activities between Japan and China: Based on National Surveys in 2011-2012. RIHE International Seminar Reports. No. 23

ERIC Educational Resources Information Center

Huang, Futao

2015-01-01

A review of recent literature suggests that, although academics in several countries (such as Japan, Korea and Germany) now allocate more of their time to research, service activities and administration than they had in the early 1990s (Teichler, Arimoto, and Cummings, 2013), the majority of university professors still spend the largest proportion…

An Analysis of the Root Causes of Delays and Deficiencies in the Development of Embedded Software for Air Force Weapon Systems

DTIC Science & Technology

1993-12-01

the ability to pull up sharply to avoid hitting hills. To maintain the ability to pull up at the level desired by the Air Force (2.4 g’s, or...by whadmss. la& akon ?dmuenua;c Alniinal Fm’mmname. Small Rcducszms in Samlmlactima in Ssghcua DagUdam in as Taedaclm Goali Cum Impac Taclmncul

Proceedings of the TRADOC/Training Developments Institute Fifth Chiefs of Analysis Seminar.

DTIC Science & Technology

1981-09-30

exposed to behaviorally specific examples of discrete points+ on a scale ( Lawton & Borman, 1978). Sel f-Assessment Trainees receive operant test...peer assessment. Psychologi- cal Bulletin, 1979., Lawton , G. W., & Borman, W. C. Constructing stimuli with known true scores for determining validity...AR Jamie B. Telegadis, West Hempstead, Rick D. Archer, Boulder, CO " . Patricia Kirkham. Cumming. GA NY - i W, - Michael F. Audet. Silver Spring. MD

Biological Response to the Dynamic Spectral-Polarized Underwater Light Field

DTIC Science & Technology

2013-09-30

Z39-18 2 optical suite including underwater video- polarimetry (full Stokes vector video-imaging camera custom-built Cummings; and “SALSA” (Bossa...operations, we couple polarimetry measurements of live, free-swimming animals in their environments with a full suite of optical measurements...Ahmed). We also restrain live, awake animals to take polarimetry measurements (in the field and laboratory) under a complete set of viewing angles and

Oral Contraceptives and Bone Health in Female Runners

DTIC Science & Technology

2007-08-01

shown that women with exercise - induced menstrual irregularities have a significantly higher frequency of stress fractures and low bone mass than...719, 2003. 6. Cumming D.C. Exercise -associated amenorrhea , low BMD, and estrogen replacement therapy. Arch Intern Med. 156:2193-2195, 1996. 7... exercise -associated amenorrhea : a brief report. Clin J Sport Med 5:246- 250, 1995. 13. Harel Z., and S. Riggs. Transdermal versus oral administration

Molecular Modeling of Interfacial Behaviors of Nanomaterials

DTIC Science & Technology

2007-05-01

potential was originally designed for the modeling of mixed covalent- ionic bonding and was successfully used to describe oxides in crystalline, glassy, and...is separates from the bulk liquid polymer, i.e., the structure of this layer, as influenced by that of the meatal surface, is significantly more...Striolo, J. Kieffer, and P. Cummings, ’Evaluation of Force- fields for molecular simulation of polyhedral oligomeric silsesquioxanes,’ J. Phys. Chem

Cultural Resources Investigation of the Reservoir Shorelines: Gull Lake, Leech Lake, Pine River, and Lake Pokegama. Volume 1,

DTIC Science & Technology

1979-06-01

topic: Typological and Stylistic Approaches tn the Analysis of Minnesota-Wisconsin Middle Woodland. (expected, 1979) SMaster of Arts : University of...Minnesota, dept. oV anthropology, 1969 Thesis topic: The Archaeology of the Snake Riier Valley, iinnesota. Bachelor of Arts , magna cum laude and with... Paleolithic site survey, Pakistan Professional Associations: American Anthropological Association, Fellow Society for American Archaeology American

Prevention of Low Back Pain in the Military: A Randomized Clinical Trial

DTIC Science & Technology

2009-06-01

interventions and strategies that are implemented during the acute episode of low back injury, before chronic symptoms occur.1 Secondary prevention reduces...SERIOUS SPINAL PATHOLOGY IN PATIENTS PRESENTING TO PRIMARY CARE WITH ACUTE LOW BACK PAIN Henschke N, Maher C, Refshauge KM, Herbert RD, Cumming R...physiotherapists, general prac- titioners, chiropractors) for acute low back pain. At the initial consul- tation clinicians recorded responses to 25

The Shock and Vibration Digest. Volume 18, Number 7

DTIC Science & Technology

1986-07-01

long-term dynamic irregularity of a soluble Los Alamos, NM, July 21-23, 1981 quantum mechanical model known as the Jaynes - Cummings model . The analysis...substructure models are obtained % substructure computation can be performed by approximating each state space vector as a independently of the other...Non- and rotational residual flexibilities at the inter- linear joint behavior is modeled by an equivalent face. Data were taken in the form of

Research in Optical Sciences

DTIC Science & Technology

1990-03-12

where this is not so (see, e.g., the Jaynes - Cummings problem). This is why this model , and the closely related micromaser, remain exceedingly important...55 one calculates the plane- wave spectrum ( without 7.), one must arbitrarily impose nearly zero phase mismatch to obtain a similar spectrum.3" 2.7...taking approximately 3 CPU minutes. To model the intentionally introduced astigmatism, a phase term was added to the input wavefront at the cell entrance

Cooling and Trapping of Neutral Atoms

DTIC Science & Technology

2009-04-30

Schrodinger equation in which the absence of the rotating wave approximation accounts for the two frequencies [18]. This result can be described in...depict this energy conservation process is the Jaynes - Cummings view, where the light field can be described as a number state. Then it becomes clear...of the problem under consideration. Find a suitable approximation for the normal modes; the simpler, the better. Decide how to model the light

Curves from Motion, Motion from Curves

DTIC Science & Technology

2000-01-01

De linearum curvarum cum lineis rectis comparatione dissertatio geometrica - an appendix to a treatise by de Lalouv~re (this was the only publication... correct solution to the problem of motion in the gravity of a permeable rotating Earth, considered by Torricelli (see §3). If the Earth is a homogeneous...in 1686, which contains the correct solution as part of a remarkably comprehensive theory of orbital motions under centripetal forces. It is a

Total Copper Analyzer for Rapid In Situ Characterization of Effluent Discharges

DTIC Science & Technology

2008-08-01

Building 345 Airdrome Road Wahiawa, HI 96786 SBWWTP operations superintendent Linda Bingler Battelle Sequim Operations PNNL 1529 West Sequim Bay ...concentration measurements by ICP-MS at the Battelle Marine Sciences Laboratory in Sequim , Washington, and a second sample was sent for analysis by GFAA...Road Sequim , WA 98382 Commercial laboratory liaison Steve West Orion Research, Inc. 500 Cummings Center Beverly, MA 01915 Industry partner A

Sorption of the Aircraft Deicing Fluid Component Methyl-Benzotriazole in Soil

DTIC Science & Technology

1999-03-01

Atlas , Ronald M., Bartha , Richard, Microbial Ecology : Fundamentals and Applications. Benjamin Cummings: Redwood City, 1993. Ball, William P., Roberts...cell; transfer of substances from one medium to another [ Atlas and Bartha , 533; Fetter, 117]. (2) The process by which a compound in solution or...oxygen, low redox potential. [ Atlas and Bartha , 534; Schwarzenbach et al, 410] Aromatic compound - Carbon skeletons containing aromatic benzene ring and

Hydrology Section Executive Committee Minutes

NASA Astrophysics Data System (ADS)

Mercer, James W.

The AGU Hydrology Section Executive Committee Meeting was called to order at approximately 4 P.M. on Monday, May 18, 1987, by Hydrology Section President Marshall Moss. In attendance were President-Elect George Pinder, Secretary Jim Mercer, Ron Cummings, Helen Joyce Peters, Peter Eagleson, Stephen Burges, Jim Wallis, Jurate Landwehr, Don Nielson, Ken Bencala, Pete Loucks, Jery Stedinger, Dennis Lettenmaier, Lenny Konikow, Ken Potter, John Wilson, Ivan Johnson, and Judy Holoviak.

Family History of Breast Cancer as a Determinant of the Risk of Developing Endometrial and Ovarian Cancers: A Nationwide Cohort Study

DTIC Science & Technology

2002-01-01

TS, Manley SA, Olopade OI, Cummings S, Garber JE, Bernhardt B, Antman K, Russo D, Wood ME, Mullineau L, Isaacs C, Peshkin B, Buys S, Venne V, Rowley... Antman K, Russo D, Wood ME, Mullineau L, Isaacs C, Peshkin B, Buys S, Venne V, Rowley PT, Loader S, Offit K, Robson M, Hampel H, Brener D, Winer EP

Genetic Counseling for Breast Cancer Susceptibility in African American Women

DTIC Science & Technology

2006-09-01

support following breast cancer diagnosis among African American women;33 the availability of spousal and/or partner support following test results... Nanda R, Schumm LP, Cummings S, Fackenthal JD, et al. Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of... diagnosis and treatment on intrusion in African American breast cancer survivors at an increased risk of hereditary disease. Studies are also needed to

Military Retention and Retirement. Reciprocal Family/Organization Effects,

DTIC Science & Technology

1981-06-30

the Chief of Naval Operations, 1978. Derr, C.B. Managing marriage/ family issues across career stages: the case of the U.S. Naval officers. Unpublished...Jeffers-, Davis Highway University of Maryland Arlingtcn VA , #02 College of Business and Management and Department of Psychology Dr. Larry Cummings...Institution 801 N. Pitt Street, Suite 120 Alexandria VA 22314 Dr. Richard Steers Graduate School of Management and Business University of Oregon Eugene

Installation Restoration Program. Phase 1: Records Search, Beale AFB, California

DTIC Science & Technology

1984-04-25

following reasons: (1) to provide the continued protaction of human health, welfare, and the environment; (2) to insure that the migration c:-. potential...Education B.S. in Biology (magna cum laude), 1975, Stetson University, Deland, Florida Ph.D. in Ecology, 1982, State University of New York, Stony Brook...ecology, entomology, plant ecology, population bio- logy, genetics, and general biology . Developed and coordinated laboratory and field exercises

Collaboration Technology in Military Operations: Lessons Learned from the Corporate Domain

DTIC Science & Technology

2006-02-01

Learned from the Corporate Domain Topics: Social Domain Issues, Cognitive Domain Issues, C2 Experimentation Authors: Stacey D. Scott, M. L. Cummings, David...AFRL-HE-WP-TP-2006-0029 AIR FORCE RESEARCH LABORATORY Collaboration Technology in Military Operations: Lessons Learned from the Corporate Domain...OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response , including the time for

Parity oscillations and photon correlation functions in the Z2-U (1 ) Dicke model at a finite number of atoms or qubits

NASA Astrophysics Data System (ADS)

Yi-Xiang, Yu; Ye, Jinwu; Zhang, CunLin

2016-08-01

Four standard quantum optics models, that is, the Rabi, Dicke, Jaynes-Cummings, and Tavis-Cummings models, were proposed by physicists many decades ago. Despite their relative simple forms and many previous theoretical works, their physics at a finite N , especially inside the superradiant regime, remain unknown. In this work, by using the strong-coupling expansion and exact diagonalization (ED), we study the Z2-U(1 ) Dicke model with independent rotating-wave coupling g and counterrotating-wave coupling g' at a finite N . This model includes the four standard quantum optics models as its various special limits. We show that in the superradiant phase, the system's energy levels are grouped into doublets with even and odd parity. Any anisotropy β =g'/g ≠1 leads to the oscillation of parities in both the ground and excited doublets as the atom-photon coupling strength increases. The oscillations will be pushed to the infinite coupling strength in the isotropic Z2 limit β =1 . We find nearly perfect agreement between the strong-coupling expansion and the ED in the superradiant regime when β is not too small. We also compute the photon correlation functions, squeezing spectrum, and number correlation functions that can be measured by various standard optical techniques.

The Effects of Chinese Herbal Medicines on the Quorum Sensing-Regulated Virulence in Pseudomonas aeruginosa PAO1.

PubMed

Chong, Yee Meng; How, Kah Yan; Yin, Wai Fong; Chan, Kok Gan

2018-04-21

The quorum sensing (QS) system has been used by many opportunistic pathogenic bacteria to coordinate their virulence determinants in relation to cell-population density. As antibiotic-resistant bacteria are on the rise, interference with QS has been regarded as a novel way to control bacterial infections. As such, many plant-based natural products have been widely explored for their therapeutic roles. These natural products may contain anti-QS compounds that could block QS signals generation or transmission to combat QS pathogens. In this study, we report the anti-QS activities of four different Chinese herbal plant extracts: Poria cum Radix pini , Angelica dahurica , Rhizoma cibotii and Schizonepeta tenuifolia , on Pseudomonas aeruginosa PAO1. All the plants extracted using hexane, chloroform and methanol were tested and found to impair swarming motility and pyocyanin production in P. aeruginosa PAO1, particularly by Poria cum Radix pini . In addition, all the plant extracts also inhibited violacein production in C. violaceum CV026 up to 50% while bioluminescence activities were reduced in lux -based E. coli biosensors, pSB401 and pSB1075, up to about 57%. These anti-QS properties of the four medicinal plants are the first documentation that demonstrates a potential approach to attenuate pathogens’ virulence determinants.

Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabolomics approach coupled with multivariate analysis.

PubMed

Tian, Jun-sheng; Liu, Cai-chun; Xiang, Huan; Zheng, Xiao-fen; Peng, Guo-jiang; Zhang, Xiang; Du, Guan-hua; Qin, Xue-mei

2015-11-01

Depression is one of the prevalent and serious mental disorders and the number of depressed patients has been on the rise globally during the recent decades. Sea buckthorn seed oil from traditional Chinese medicine (TCM) is edible and has been widely used for treatment of different diseases for a long time. However, there are few published reports on the antidepressant effect of sea buckthorn seed oil. With the objective of finding potential biomarkers of the therapeutic response of sea buckthorn seed oil in chronic unpredictable mild stress (CUMS) rats, urine metabolomics based on gas chromatography-mass spectrometry (GC-MS) coupled with multivariate analysis was applied. In this study, we discovered a higher level of pimelic acid as well as palmitic acid and a lower level of suberic acid, citrate, phthalic acid, cinnamic acid and Sumiki's acid in urine of rats exposed to CUMS procedures after sea buckthorn seed oil was administered. These changes of metabolites are involved in energy metabolism, fatty acid metabolism and other metabolic pathways as well as in the synthesis of neurotransmitters and it is helpful to facilitate the efficacy evaluation and mechanism elucidating the effect of sea buckthorn seed oil for depression management.

Extraction Optimization, Characterization, and Bioactivities of Polysaccharides from Pinelliae Rhizoma Praeparatum Cum Alumine Employing Ultrasound-Assisted Extraction.

PubMed

Liu, Yu-Jie; Mo, Xue-Lin; Tang, Xiao-Zhang; Li, Jiang-Hua; Hu, Mei-Bian; Yan, Dan; Peng, Wei; Wu, Chun-Jie

2017-06-09

In this study, the ultrasound-assisted extraction of polysaccharides (PSA) from Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) was optimized by response surface methodology (RSM). The structural characteristics of PSA were analyzed by UV-vis spectroscopy, infrared spectroscopy, scanning electron microscopy, high performance gel permeation chromatography and high performance liquid chromatography, respectively. In addition, antioxidant and antimicrobial activities of PSA were studied by different in vitro assays. Results indicated that the optimal extraction conditions were as follows: the ratio of water to raw of 30 mL/g, extraction time of 46.50 min, ultrasonic temperature of 72.00 °C, and ultrasonic power of 230 W. Under these conditions, the obtained PSA yield (13.21 ± 0.37%) was closely agreed with the predicted yield by the model. The average molecular weights of the PSA were estimated to be 5.34 × 10³ and 6.27 × 10⁵ Da. Monosaccharide composition analysis indicated that PSA consisted of mannose, galactose uronic acid, glucose, galactose, arabinose with a molar ratio of 1.83:0.55:75.75:1.94:0.45. Furthermore, PSA exhibited moderate antioxidant and antibacterial activities in vitro. Collectively, this study provides a promising strategy to obtain bioactive polysaccharides from processed products of herbal medicines.

Does marital conflict predict infants' physiological regulation? A short-term prospective study.

PubMed

Porter, Christin L; Dyer, W Justin

2017-06-01

Prior research has linked marital conflict to children's internalizing/externalizing disorders, insecure attachment, and poor emotional regulation (e.g., Cummings & Davies, 2010; Cummings, Iannotti, & Zahn-Waxler, 1985). Although investigators have examined the impact of marital discord on older children (e.g., Crockenberg & Langrock, 2001), few have explored direct links in infancy (e.g., Cowan & Cowan, 1999). This study extends earlier work by examining linkages between marital functioning (conflict and harmony) and infants' cardiac vagal tone and developmental status across 2 time points using a cross-lag approach. Differential findings were found for boys and girls, with concurrent linkages between marital love and vagal tone at 6 months for boys and girls but only for boys at 12 months. In addition, marital conflict at 6 months predicted lower cardiac vagal tone in girls at 12 months but not boys. Finally, infants' developmental status at 6 months was found to predict marital conflict at 12 months. Higher scores on the Psychomotor Development Index (PDI) predicted greater marital conflict whereas higher scores on the Mental Development Index (MDI) predicted lower conflict. These findings are discussed in the context of the emotional security hypothesis and the spillover framework as well as differential susceptibilities to early developmental contexts. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice.

PubMed

Liu, Xiao-Long; Luo, Liu; Mu, Rong-Hao; Liu, Bin-Bin; Geng, Di; Liu, Qing; Yi, Li-Tao

2015-11-02

Previous studies have demonstrated that the mammalian target of rapamycin (mTOR) signaling pathway has an important role in ketamine-induced, rapid antidepressant effects despite the acute administration of fluoxetine not affecting mTOR phosphorylation in the brain. However, the effects of long-term fluoxetine treatment on mTOR modulation have not been assessed to date. In the present study, we examined whether fluoxetine, a type of commonly used antidepressant agent, alters mTOR signaling following chronic administration in different brain regions, including the frontal cortex, hippocampus, amygdala and hypothalamus. We also investigated whether fluoxetine enhanced synaptic protein levels in these regions via the activation of the mTOR signaling pathway and its downstream regulators, p70S6K and 4E-BP-1. The results indicated that chronic fluoxetine treatment attenuated the chronic, unpredictable, mild stress (CUMS)-induced mTOR phosphorylation reduction in the hippocampus and amygdala of mice but not in the frontal cortex or the hypothalamus. Moreover, the CUMS-decreased PSD-95 and synapsin I levels were reversed by fluoxetine, and these effects were blocked by rapamycin only in the hippocampus. In conclusion, our findings suggest that chronic treatment with fluoxetine can induce synaptic protein expression by activating the mTOR signaling pathway in a region-dependent manner and mainly in the hippocampus.

Development of a mixed seawater-hydrothermal fluid geochemical signature during alteration of volcanic rocks in the Archean (∼2.7 Ga) Abitibi Greenstone Belt, Canada

NASA Astrophysics Data System (ADS)

Brengman, Latisha A.; Fedo, Christopher M.

2018-04-01

We investigated a group of silicified volcanic rocks from the ∼2.72 Ga Hunter Mine Group (HMG), Abitibi Greenstone Belt, Canada, in order to document progressive compositional change associated with alteration in a subaqueous caldera system. Rocks of the HMG divide into three groups based on mineralogy and texture for petrographic and geochemical analyses. Volcanic features (phenocrysts, pseudomorphs after primary glass shards, lapilli, volcanic clasts) are preserved in all groups, despite changing mineralogy from primarily quartz, feldspar, chlorite (Groups 1 and 2), to quartz, hematite and carbonate (Groups 2 and 3). Compositionally, Group 1 rocks resemble volcanic rocks in the region, while Group 2 and 3 rocks show a change in mineralogy to iron, silica, and carbonate minerals, which is associated with depletion of many major and trace elements associated with volcanic rocks (Al2O3, Na2O, K2O, Zr). In addition, rare earth elements display a clear progression from volcanic signatures in Group 1 (PrSN/YbSN = 1.7-2.96, EuSN/EuSN∗ = 0.84-1.72, Y/Ho = 25.20-27.41, LaSN/LaSN∗ = 0.97-1.29, and Zr/Hf = 38.38-42.09) to transitional mixed volcanic, hydrothermal, and seawater signatures in Group 2 (PrSN/YbSN 1.33-2.89, EuSN/EuSN∗ 1.33-2.5, Y/Ho = 23.94-30, LaSN/LaSN∗ 0.93-1.34, and Zr/Hf = 40-70), to mixed hydrothermal and seawater signatures in Group 3 (PrSN/YbSN 0.62-2.88, EuSN/EuSN∗ 1.30-7.15, LaSN/LaSN∗ 1.02-1.86, Y/Ho = 25.56-55, and Zr/Hf = 35-50). We interpret that silicification of volcanic rocks (Group 1) produced transitional altered volcanic rocks (Group 2), and siliceous and jaspilitic rocks (Group 3), based on preservation of delicate volcanic features. Building on this explanation, we interpret that major, trace- and rare-earth element mobility occurred during the process of silicification, during which siliceous and jaspilitic rocks (Group 3) acquired aspects of the rare-earth element geochemical signatures of marine chemical precipitates. We conclude that seafloor silicification in hydrothermal depositional settings is capable of producing rocks that resemble marine chemical precipitates such as banded iron formation, and could be a process that is widespread in the Archean. Consequently, because silicified volcanic rocks from the HMG possess mixed seawater and hydrothermal rare-earth element characteristics similar to Archean iron formations and cherts, we suggest caution must be exercised when interpreting the geochemical information preserved in metamorphosed rocks where original genesis is unknown.

Grassmann phase space theory and the Jaynes–Cummings model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dalton, B.J., E-mail: bdalton@swin.edu.au; Centre for Atom Optics and Ultrafast Spectroscopy, Swinburne University of Technology, Melbourne, Victoria 3122; Garraway, B.M.

2013-07-15

The Jaynes–Cummings model of a two-level atom in a single mode cavity is of fundamental importance both in quantum optics and in quantum physics generally, involving the interaction of two simple quantum systems—one fermionic system (the TLA), the other bosonic (the cavity mode). Depending on the initial conditions a variety of interesting effects occur, ranging from ongoing oscillations of the atomic population difference at the Rabi frequency when the atom is excited and the cavity is in an n-photon Fock state, to collapses and revivals of these oscillations starting with the atom unexcited and the cavity mode in a coherentmore » state. The observation of revivals for Rydberg atoms in a high-Q microwave cavity is key experimental evidence for quantisation of the EM field. Theoretical treatments of the Jaynes–Cummings model based on expanding the state vector in terms of products of atomic and n-photon states and deriving coupled equations for the amplitudes are a well-known and simple method for determining the effects. In quantum optics however, the behaviour of the bosonic quantum EM field is often treated using phase space methods, where the bosonic mode annihilation and creation operators are represented by c-number phase space variables, with the density operator represented by a distribution function of these variables. Fokker–Planck equations for the distribution function are obtained, and either used directly to determine quantities of experimental interest or used to develop c-number Langevin equations for stochastic versions of the phase space variables from which experimental quantities are obtained as stochastic averages. Phase space methods have also been developed to include atomic systems, with the atomic spin operators being represented by c-number phase space variables, and distribution functions involving these variables and those for any bosonic modes being shown to satisfy Fokker–Planck equations from which c-number Langevin equations are often developed. However, atomic spin operators satisfy the standard angular momentum commutation rules rather than the commutation rules for bosonic annihilation and creation operators, and are in fact second order combinations of fermionic annihilation and creation operators. Though phase space methods in which the fermionic operators are represented directly by c-number phase space variables have not been successful, the anti-commutation rules for these operators suggest the possibility of using Grassmann variables—which have similar anti-commutation properties. However, in spite of the seminal work by Cahill and Glauber and a few applications, the use of phase space methods in quantum optics to treat fermionic systems by representing fermionic annihilation and creation operators directly by Grassmann phase space variables is rather rare. This paper shows that phase space methods using a positive P type distribution function involving both c-number variables (for the cavity mode) and Grassmann variables (for the TLA) can be used to treat the Jaynes–Cummings model. Although it is a Grassmann function, the distribution function is equivalent to six c-number functions of the two bosonic variables. Experimental quantities are given as bosonic phase space integrals involving the six functions. A Fokker–Planck equation involving both left and right Grassmann differentiations can be obtained for the distribution function, and is equivalent to six coupled equations for the six c-number functions. The approach used involves choosing the canonical form of the (non-unique) positive P distribution function, in which the correspondence rules for the bosonic operators are non-standard and hence the Fokker–Planck equation is also unusual. Initial conditions, such as those above for initially uncorrelated states, are discussed and used to determine the initial distribution function. Transformations to new bosonic variables rotating at the cavity frequency enable the six coupled equations for the new c-number functions–that are also equivalent to the canonical Grassmann distribution function–to be solved analytically, based on an ansatz from an earlier paper by Stenholm. It is then shown that the distribution function is exactly the same as that determined from the well-known solution based on coupled amplitude equations. In quantum–atom optics theories for many atom bosonic and fermionic systems are needed. With large atom numbers, treatments must often take into account many quantum modes—especially for fermions. Generalisations of phase space distribution functions of phase space variables for a few modes to phase space distribution functionals of field functions (which represent the field operators, c-number fields for bosons, Grassmann fields for fermions) are now being developed for large systems. For the fermionic case, the treatment of the simple two mode problem represented by the Jaynes–Cummings model is a useful test case for the future development of phase space Grassmann distribution functional methods for fermionic applications in quantum–atom optics. -- Highlights: •Novel phase space theory of the Jaynes–Cummings model using Grassmann variables. •Fokker–Planck equations solved analytically. •Results agree with the standard quantum optics treatment. •Grassmann phase space theory applicable to fermion many-body problems.« less

Entanglement evaluation with atomic Fisher information

NASA Astrophysics Data System (ADS)

Obada, A.-S. F.; Abdel-Khalek, S.

2010-02-01

In this paper, the concept of atomic Fisher information (AFI) is introduced. The marginal distributions of the AFI are defined. This quantity is used as a parameter of entanglement and compared with linear and atomic Wehrl entropies of the two-level atom. The evolution of the atomic Fisher information and atomic Wehrl entropy for only the pure state (or dissipation-free) of the Jaynes-Cummings model is analyzed. We demonstrate the connections between these measures.

Cultural Organization: Fragments of a Theory,

DTIC Science & Technology

1983-11-01

34 In B. Staw & L.L. Cummings (eds.) Research in Organization Behavior , Vol. 6, Greenwich, CT: JAI Press, 1963. November, 1982. 0070-11H 0983 TR-11 Bailyn... Behavior . November, 1982. TR-12 Schein, Edgar H. "The Role of the Founder In the Creation of Organizational Culture." Organizational Dynamics, Summer...34 Forthcoming in J. Lorscb (ed.) Handbook of Organizational Behavior , Englewood Cliffs, NJ: Prentice-Hall. May, 1983. TR-20 Van Maanen, John

Work and Career considerations in Understanding Employee Turnover Intentions and Turnover: Development of the Turnover Diagnostic.

DTIC Science & Technology

1984-08-01

speciflying some of these factor. Employee Turnover 22 References Alderfer , C . P., & Brown, L. D. (1972). Designing an "empathic questionnaire" for...organizational research. Journal of Applied Psychology 5 456-460. Alley, W. E ., & Gould, R . B. (1975). Feasibility of estimating personnel turnover from...leadership behavior related to employee grievances and turnover. Personnel Psychology, 15 43-56. Forrest, C . R ., Cummings, L. L., & Johnson, A. C

Team Dimensions: Their Identity, Their Measurement and Their Relationships

DTIC Science & Technology

1985-01-01

business games (e.g., Cummings, Huber & Arendt, 1974; Kennedy, 1971 ). Apart from the problem solving tasks, the second largest group of studies...positive relationship between size and number of answers on. an anagram task. In a disjunctive problem, solving-task-, Frank & Anderson ( 1971 ) found that...4, or 5 members. However, there were no differences between the groups in time to solutions. Goldman ( 1971 ) found posi’tive effects for size with

Nonlinear Oscillations of Microscale Piezoelectric Resonators and Resonator Arrays

DTIC Science & Technology

2006-06-30

REO TD C M NA INPG Form ApprovedREPO T D CUM NTATON AGEOMB No. 0704-0188 Public reporting burden for this collection of information is estimated to...average 1 hour per response, including the time for reviewing instructions, searching data sources , gathering and maintaining the data needed, and...completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information

Computational Nanotribology of Nanometer Confined Liquid Films

DTIC Science & Technology

2012-02-29

Nanotribology of Nanometer Confined Liquid Films 5b. GRANT NUMBER FA9550-08-1-0214 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT...NUMBER Yongsheng Leng & Peter T. Cummings 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES...NAME( S ) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM( S ) Joycelyn Harrison AFOSR/RSA 875 North Randolph Street 11. SPONSOR/MONITOR’S REPORT

Evaluation of Cement, Lime, and Asphalt Amended Municipal Solid Waste Incinerator Residues

DTIC Science & Technology

1989-09-01

the lime column over time ( Atlas & Bartha , 1987). Certainly, a more extensive evaluation of the lime amended residue’s microbial activity is required...4.02 ASTM D 1559 (1988) Annual Book of ASTM Standards: Road & Paving Materials; Traveled Surface Characteristics, Sec 4, Vol 4.03 Atlas , R. & R. Bartha ...1987) Microbial Ecology : Fundamentals & Applications, Benjamin-Cummings, Menlo, CA Barrow N., J. Bowden, A. Posner, & J. Quirk (1981) Describing the

GODAE Inter-Comparisons in the Tasman and Coral Seas

DTIC Science & Technology

2012-08-01

sea surface temperature analysis over the Australian region. Submitted. 27. Steinberg C. 2007. Impacts of climate change on the physical...oceanography of the Great Barrier Reef. In: Climate Change and the Great Barrier Reef, Johnson JE and Marshall PA (eds), pp51–74, Great Barrier Reef Mar. Park...GB Brassington2, J Cummings3, M Martin4, F Hernandez5 1The Centre for Australian Weather and Climate Research (CAWCR), Commonwealth Scientific and

Neuronal Functions Associated with Endo- and Exocytotic Events-cum-Molecular Trafficking May Be Cell Maturation-Dependent: Lessons Learned from Studies on Botulism

DTIC Science & Technology

2011-01-01

Clostridium botulinum type A progenitor toxins . Infect Immun 64:1589–1594 Li L, Singh BR (1999) Structure -function relationship of clostridial...experimental design and demonstration of the validity of the targeted neurologic therapeutic delivery approach based on recombinant botulinum toxin ...Endocytosis Exocytosis Molecular trafficking Cell maturation Botulism Targeted therapeutic Background Botulinum neurotoxins (BoNTs) are produced by

A Synopsis of Marine Animal Underwater Sounds in Eight Geographic Areas

DTIC Science & Technology

1971-05-28

MAMMALS (1) HIGHEST PROBABILITY Delphinapterus leucas - In Apr.-June they move up Kola River. Present all months except July) Aug, Sept...its vocali- zations are available from Dr. W. C. Cummings, NUC Code 5054. : ii V, , 71 Delphinapterus leucas --(white-whale or beluga) The beluga is...about 5 msoc. ~7 * Delphinapterus leucas --(white whale or beluga-continued Our own estimates of source level for sounds from an individual whale 2 are

Lack of behavioural responses of humpback whales (Megaptera novaeangliae) indicate limited effectiveness of sonar mitigation.

PubMed

Wensveen, Paul J; Kvadsheim, Petter H; Lam, Frans-Peter A; von Benda-Beckmann, Alexander M; Sivle, Lise D; Visser, Fleur; Curé, Charlotte; Tyack, Peter L; Miller, Patrick J O

2017-11-15

Exposure to underwater sound can cause permanent hearing loss and other physiological effects in marine animals. To reduce this risk, naval sonars are sometimes gradually increased in intensity at the start of transmission ('ramp-up'). Here, we conducted experiments in which tagged humpback whales were approached with a ship to test whether a sonar operation preceded by ramp-up reduced three risk indicators - maximum sound pressure level (SPL max ), cumulative sound exposure level (SEL cum ) and minimum source-whale range ( R min ) - compared with a sonar operation not preceded by ramp-up. Whales were subject to one no-sonar control session and either two successive ramp-up sessions (RampUp1, RampUp2) or a ramp-up session (RampUp1) and a full-power session (FullPower). Full-power sessions were conducted only twice; for other whales we used acoustic modelling that assumed transmission of the full-power sequence during their no-sonar control. Averaged over all whales, risk indicators in RampUp1 ( n =11) differed significantly from those in FullPower ( n =12) by -3.0 dB (SPL max ), -2.0 dB (SEL cum ) and +168 m ( R min ), but not significantly from those in RampUp2 ( n =9). Only five whales in RampUp1, four whales in RampUp2 and none in FullPower or control sessions avoided the sound source. For RampUp1, we found statistically significant differences in risk indicators between whales that avoided the sonar and whales that did not: -4.7 dB (SPL max ), -3.4 dB (SEL cum ) and +291 m ( R min ). In contrast, for RampUp2, these differences were smaller and not significant. This study suggests that sonar ramp-up has a positive but limited mitigative effect for humpback whales overall, but that ramp-up can reduce the risk of harm more effectively in situations when animals are more responsive and likely to avoid the sonar, e.g. owing to novelty of the stimulus, when they are in the path of an approaching sonar ship. © 2017. Published by The Company of Biologists Ltd.

Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.

PubMed

Wang, Jiajia; Li, Xiaofang; He, Shugui; Hu, Lijun; Guo, Jiewen; Huang, Xiangning; Hu, Jinqing; Qi, Yaoqun; Chen, Bin; Shang, Dewei; Wen, Yuguan

2018-03-25

Xiaoyao San (XYS) is a classic Chinese herbal formula for treatment of depression. The present study aimed to investigate the antidepressant effects of XYS in a rat model of chronic unpredictable mild stress (CUMS) and the underlying mechanisms. A CUMS rat model of depression was established via 4 weeks of unpredictable stimulation. Then the rats were orally administered paroxetine and XYS for 2 weeks with continued stress. Behavioral assessments, including an open field test (OFT), sucrose preference test (SPT) and forced swim test (FST), were conducted to evaluate the antidepressant effects of XYS. The concentrations in rat plasma of tryptophan (Trp) and its metabolic products, including kynurenine (Kyn) and quinolinic acid (QUIN), were determined using high performance liquid chromatography tandem mass spectrometry with electrochemical detection (HPLC-MS/MS). The mRNA and protein levels in rat hippocampus of depression-related brain derived neurotrophic factor (BDNF), cyclic AMP response element binding protein (CREB) and nerve cell adhesion molecule (NCAM) were determined by real-time qPCR and Western blot, respectively. Enzyme Linked Immunosorbent Assay (ELISA) was used to detect the activities of indoleamine 2,3-dioxygenase (IDO) and kynurenine-3-monooxygenase (KMO) in rat plasma. The results showed that a successful CUMS rat model was established through 4 weeks of continuous unpredictable stimulation, as indicated by the significant decrease in locomotor activity and increase in immobility time in the OFT, reduction in body weight and food intake etc. Compared with the normal group, the concentrations of Kyn and QUIN had significantly (p < 0.05) decreased at day 28 in the control group, but then improved after drug treatment with paroxetine and XYS. There were no obvious changes in the activities of IDO and KMO. Compared with the normal group, the mRNA of NCAM, CREB and BDNF were significantly down-regulated (p < 0.001) in the control group, BDNF gene was up-regulated by paroxetine or XYS treatment, NCAM and CREB gene did not change in XYS group, protein expressions of BDNF and CREB were significantly increased, and NCAM was significantly reduced (p < 0.05). XYS reversed the abnormalities of the tryptophan-kynurenine metabolic pathways in depressed rats and achieved an excellent antidepressant effect. Its direct impact may be observed as changes in biological indicators in rat hippocampus tissue. Copyright © 2017 Elsevier B.V. All rights reserved.

Micromachined Integrated Quantum Circuit Containing a Superconducting Qubit

NASA Astrophysics Data System (ADS)

Brecht, T.; Chu, Y.; Axline, C.; Pfaff, W.; Blumoff, J. Z.; Chou, K.; Krayzman, L.; Frunzio, L.; Schoelkopf, R. J.

2017-04-01

We present a device demonstrating a lithographically patterned transmon integrated with a micromachined cavity resonator. Our two-cavity, one-qubit device is a multilayer microwave-integrated quantum circuit (MMIQC), comprising a basic unit capable of performing circuit-QED operations. We describe the qubit-cavity coupling mechanism of a specialized geometry using an electric-field picture and a circuit model, and obtain specific system parameters using simulations. Fabrication of the MMIQC includes lithography, etching, and metallic bonding of silicon wafers. Superconducting wafer bonding is a critical capability that is demonstrated by a micromachined storage-cavity lifetime of 34.3 μ s , corresponding to a quality factor of 2 ×106 at single-photon energies. The transmon coherence times are T1=6.4 μ s , and T2echo=11.7 μ s . We measure qubit-cavity dispersive coupling with a rate χq μ/2 π =-1.17 MHz , constituting a Jaynes-Cummings system with an interaction strength g /2 π =49 MHz . With these parameters we are able to demonstrate circuit-QED operations in the strong dispersive regime with ease. Finally, we highlight several improvements and anticipated extensions of the technology to complex MMIQCs.

Hyperintense White Matter Lesions in 50 High-Altitude Pilots with Neurologic Decompression Sickness

DTIC Science & Technology

2012-12-01

Environ Med 2004 ; 75 : 969 – 72 . 4. Bartzokis G, Tishler TA, Shin IS, Lu PH, Cummings JL . Brain ferritin iron as a risk factor for...Coyle T, Lancaster J, et al. Can structural MRI indices of cerebral integrity track cognitive trends in executive control function during normal...Digital brain atlases . Trends Neurosci 1995 ; 18 : 210 – 1 . 28. Miura K, Soyama Y, Morikawa Y, Nishijo M, Nakanishi Y, et al

Groundwater quality in the Southern Sierra Nevada, California

USGS Publications Warehouse

Fram, Miranda S.; Belitz, Kenneth

2012-01-01

Groundwater provides more than 40 percent of California's drinking water. To protect this vital resource, the State of California created the Groundwater Ambient Monitoring and Assessment (GAMA) Program. The Priority Basin Project of the GAMA Program provides a comprehensive assessment of the State's groundwater quality and increases public access to groundwater-quality information. The Tehachapi-Cummings Valley and Kern River Valley basins and surrounding watersheds in the Southern Sierra Nevada constitute one of the study units being evaluated.

U.S. GODAE: Global Ocean Prediction with the Hybrid Coordinate Ocean Model (HYCOM)

DTIC Science & Technology

2009-01-01

Cummings, G. Jacobs, H. Ngodock, C.A. Blain, P. Hogan , J. Kindle), NAVOCEANO (F. Bub), FNMOC (M. Clancy), NRL/MONTEREY (R. Hodur, J. Pullen, P. May...Carolina (C. Werner), Rutgers (J. Wilkin ), U. of S. Florida (R. Weisberg), Horizon Marine Inc. (J. Feeney, S. Anderson), ROFFS (M. Roffer), Shell Oil... 2008 and 2009, the Coastal Ocean Observing Lab at Rutgers University attempted two trans-Atlantic flights using Slocum gliders. These began off the

Liquid Crystal Airborne Display

DTIC Science & Technology

1977-08-01

Cum.nings, J. P., et al., Properties and Limitations oe Liquid Crystals for Aircraft Displays, Honeywell Corporate Researc ."I Center, Final Report HR-72...basic module could be used to build displays for both the commercial and military! 157- marhecs, and so would establi sh a broad and sizable market ... market for the display becomes a reality; therein lies, f TABLE 16 THE COURSE OF FUTURE DISPLAY DEVELOPMENT Today 1976-77 1980 1985 Display Size 2" 1 3.2

Computer Systems Acquisition Metrics Handbook. Volume II. Quality Factor Modules.

DTIC Science & Technology

1982-05-01

are unable to evil .mte) IPAW BrY: APFD If: i Ef-24 EFFICICYe: EfPDF.l L C1E PHASE: Sota S): PRELINARY DESIGN EfP. 1 EfDC. 2 = StSM NAM:. I. CUM...unable to evaluate) Iv. D6PB=’S C3#rm: PWAPM BY:______ APFD N _______ Po-30 MACHM NDE WM4 MEASE SO= Go&e:. PoII4LS LIM P E PHAiSE: SJRMCs): IMPLEME

A Guide to Implementing Reclamation Processes at Department of Defense Municipal Solid Waste and Construction Debris Landfills

DTIC Science & Technology

1993-09-21

34Solid Wastes: Solving a Growing Problem," in Environmental Science . ed. by Daniel D. Chiras . RedwoodCity, CA: Benjamin/Cummings Publishing Company, Inc...of Master of Science in Engineering and Environmental Management Gregory L. Tures, B. Arch. Captain, USAF September 1993 Approved for public release...121: 88 (May 1990). Burton, G. Allen. Class Lecture, BIO 615, Environmental Toxicology. Department of Biological Science , College of Science and

Distance Education in Higher Education. Inter-Country Study Visit-cum-Mobile Workshop (Sukhothai Thammathirat Open University, Bangkok, Thailand, and Darling Downs Institute of Advanced Education, Toowoomba, Queensland, Australia, September 6-16, 1983).

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Bangkok (Thailand). Regional Office for Education in Asia and the Pacific.

The outcome of a study workshop with participants from 11 Asian and Pacific countries, this report is broadly divided into four chapters. The first gives an overview of the philosophical concept and challenges of distance education at the higher education level in the context of this region. The second chapter contains synopses of reports…

Towards an Ontology of Physics

DTIC Science & Technology

2014-07-01

Sept 14-19 2003, Paper 03F- SIW -007. [2] P. G. Foley, F. Mamaghani, P. A. Birkel, “The Synthetic Data Representation and Interchange Specification...the Spring 2003 Sim- ulation Interoperability Workshop, Orlando FL, March 30-April 4 2003, Paper 03S- SIW -054. [7] M.D. Petty and E.W. Weisel, “A...4 2003, Paper 03S- SIW -023. [8] G. Booch, “Object-Oriented Analysis and Design with Applications”, Benjamin/Cummings (1994) [9] L.D. Landau, E.M

Characterization of Strong Light-Matter Coupling in Semiconductor Quantum-Dot Microcavities via Photon-Statistics Spectroscopy

NASA Astrophysics Data System (ADS)

Schneebeli, L.; Kira, M.; Koch, S. W.

2008-08-01

It is shown that spectrally resolved photon-statistics measurements of the resonance fluorescence from realistic semiconductor quantum-dot systems allow for high contrast identification of the two-photon strong-coupling states. Using a microscopic theory, the second-rung resonance of Jaynes-Cummings ladder is analyzed and optimum excitation conditions are determined. The computed photon-statistics spectrum displays gigantic, experimentally robust resonances at the energetic positions of the second-rung emission.

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

PubMed Central

Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang

2014-01-01

Abstract Maca has been consumed as a medical food in Peru for thousands of years, and exerts anxiolytic and antidepressant effects. Our present study aimed to evaluate the behavior and anatomical and biochemical effects of petroleum ether extract from maca (ME) in the chronic unpredictable mild stress (CUMS) model of depression in mice. Three different doses of maca extract (125, 250, and 500 mg/kg) were orally administrated in the six-week CUMS procedure. Fluoxetine (10 mg/kg) was used as a positive control drug. Maca extract (250 and 500 mg/kg) significantly decreased the duration of immobility time in the tail suspension test. After treatment with maca extract (250 and 500 mg/kg), the granule cell layer in the dentate gyrus appeared thicker. Maca extract (250 and 500 mg/kg) also induced a significant reduction in corticosterone levels in mouse serum. In mouse brain tissue, after six weeks of treatment, noradrenaline and dopamine levels were increased by maca extract, and the activity of reactive oxygen species was significantly inhibited. Serotonin levels were not significantly altered. These results demonstrated that maca extract (250 and 500 mg/kg) showed antidepressant-like effects and was related to the activation of both noradrenergic and dopaminergic systems, as well as attenuation of oxidative stress in mouse brain. PMID:24730393

Antidepressant-like behavioral, anatomical, and biochemical effects of petroleum ether extract from maca (Lepidium meyenii) in mice exposed to chronic unpredictable mild stress.

PubMed

Ai, Zhong; Cheng, Ai-Fang; Yu, Yuan-Tao; Yu, Long-Jiang; Jin, Wenwen

2014-05-01

Maca has been consumed as a medical food in Peru for thousands of years, and exerts anxiolytic and antidepressant effects. Our present study aimed to evaluate the behavior and anatomical and biochemical effects of petroleum ether extract from maca (ME) in the chronic unpredictable mild stress (CUMS) model of depression in mice. Three different doses of maca extract (125, 250, and 500 mg/kg) were orally administrated in the six-week CUMS procedure. Fluoxetine (10 mg/kg) was used as a positive control drug. Maca extract (250 and 500 mg/kg) significantly decreased the duration of immobility time in the tail suspension test. After treatment with maca extract (250 and 500 mg/kg), the granule cell layer in the dentate gyrus appeared thicker. Maca extract (250 and 500 mg/kg) also induced a significant reduction in corticosterone levels in mouse serum. In mouse brain tissue, after six weeks of treatment, noradrenaline and dopamine levels were increased by maca extract, and the activity of reactive oxygen species was significantly inhibited. Serotonin levels were not significantly altered. These results demonstrated that maca extract (250 and 500 mg/kg) showed antidepressant-like effects and was related to the activation of both noradrenergic and dopaminergic systems, as well as attenuation of oxidative stress in mouse brain.

Acoustic Prediction Methodology and Test Validation for an Efficient Low-Noise Hybrid Wing Body Subsonic Transport

NASA Technical Reports Server (NTRS)

Kawai, Ronald T. (Compiler)

2011-01-01

This investigation was conducted to: (1) Develop a hybrid wing body subsonic transport configuration with noise prediction methods to meet the circa 2007 NASA Subsonic Fixed Wing (SFW) N+2 noise goal of -52 dB cum relative to FAR 36 Stage 3 (-42 dB cum re: Stage 4) while achieving a -25% fuel burned compared to current transports (re :B737/B767); (2) Develop improved noise prediction methods for ANOPP2 for use in predicting FAR 36 noise; (3) Design and fabricate a wind tunnel model for testing in the LaRC 14 x 22 ft low speed wind tunnel to validate noise predictions and determine low speed aero characteristics for an efficient low noise Hybrid Wing Body configuration. A medium wide body cargo freighter was selected to represent a logical need for an initial operational capability in the 2020 time frame. The Efficient Low Noise Hybrid Wing Body (ELNHWB) configuration N2A-EXTE was evolved meeting the circa 2007 NRA N+2 fuel burn and noise goals. The noise estimates were made using improvements in jet noise shielding and noise shielding prediction methods developed by UC Irvine and MIT. From this the Quiet Ultra Integrated Efficient Test Research Aircraft #1 (QUIET-R1) 5.8% wind tunnel model was designed and fabricated.

Sub-anesthetic doses of ketamine exert antidepressant-like effects and upregulate the expression of glutamate transporters in the hippocampus of rats.

PubMed

Zhu, Xianlin; Ye, Gang; Wang, Zaiping; Luo, Jie; Hao, Xuechao

2017-02-03

Clinical studies on the role of the glutamatergic system in the pathogenesis of depression found that ketamine induces an antidepressant response, but the molecular mechanisms remain unclear. The present study investigated the effects of sub-anesthetic doses of ketamine on the glutamate reuptake function in the rat hippocampus. Chronic unpredictable mild stress (CUMS) was applied to construct animal models of depression. Sixty adult male Sprague-Dawley rats were randomly assigned to 5 groups and received a different regimen of CUMS and ketamine (10, 25, and 50mg/kg) treatment. The sucrose preference test and open-field test were used to assess behavioral changes. The expression levels of excitatory amino acid transporters (EAATs) were measured by western blot. Microdialysis and high-performance liquid chromatography (HPLC) were used to detect hippocampal glutamate concentrations. We found that the expression of EAAT2 and EAAT3 were obviously downregulated, and extracellular concentrations of glutamate were significantly increased in the hippocampi of depressive-like rats. Ketamine (10, 25, and 50mg/kg) upregulated the expression of EAAT2 and EAAT3, decreased the hippocampal concentration of extracellular glutamate, and alleviated the rats' depressive-like behavior. The antidepressant effect of ketamine may be linked to the regulation of EAAT expression and the enhancement of glutamate uptake in the hippocampus of depressive-like rats. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Impact of chronic unpredicted mild stress-induced depression on repaglinide fate via glucocorticoid signaling pathway.

PubMed

Wei, Hongyan; Zhou, Ting; Tan, Boyu; Zhang, Lei; Li, Mingming; Xiao, Zhijun; Xu, Feng

2017-07-04

Chronic unpredicted mild stress (CUMS)-induced depression could alter the pharmacokinetics of many drugs in rats, however, the underlying mechanism is not clear. In this work we studied the pharmacokinetics of repaglinide, and explored the role of glucocorticoid and adrenergic signaling pathway in regulating drug metabolizing enzymes (DMEs) in GK rats and BRL 3A cells. The plasma cortisol and epinephrine levels were increased, meanwhile the pharmacokinetics of repaglinide were altered significantly in depression model rats. Forty-nine genes in liver of model rats displayed significant difference comparing to control rats. The differentially expressed genes enriched in the drug metabolism and steroid hormone biosynthesis pathway significantly, and Nr1i3 matched 335 connectivity genes. CAR and Ugt1a1 protein expression were enhanced significantly in liver of model rats. The mRNA expression of Ugt1a1 and Nr1i2 were increased 2 and 4 times respectively with dexamethasone (DEX) and 8-Br-cAMP co-treatment in BRL 3A cells. The protein expression of PXR was up-regulated, too. However, RU486 reversed the up-regulated effect. The adrenergic receptor agonists had little impact on the DMEs in BRL 3A. Our data suggested that CUMS-induced depression might up-regulate DMEs expression via glucocorticoid signaling pathway, and accelerate the fate of the repaglinide in spontaneous diabetes rats.

Impact of chronic unpredicted mild stress-induced depression on repaglinide fate via glucocorticoid signaling pathway

PubMed Central

Tan, Boyu; Zhang, Lei; Li, Mingming; Xiao, Zhijun; Xu, Feng

2017-01-01

Chronic unpredicted mild stress (CUMS)-induced depression could alter the pharmacokinetics of many drugs in rats, however, the underlying mechanism is not clear. In this work we studied the pharmacokinetics of repaglinide, and explored the role of glucocorticoid and adrenergic signaling pathway in regulating drug metabolizing enzymes (DMEs) in GK rats and BRL 3A cells. The plasma cortisol and epinephrine levels were increased, meanwhile the pharmacokinetics of repaglinide were altered significantly in depression model rats. Forty-nine genes in liver of model rats displayed significant difference comparing to control rats. The differentially expressed genes enriched in the drug metabolism and steroid hormone biosynthesis pathway significantly, and Nr1i3 matched 335 connectivity genes. CAR and Ugt1a1 protein expression were enhanced significantly in liver of model rats. The mRNA expression of Ugt1a1 and Nr1i2 were increased 2 and 4 times respectively with dexamethasone (DEX) and 8-Br-cAMP co-treatment in BRL 3A cells. The protein expression of PXR was up-regulated, too. However, RU486 reversed the up-regulated effect. The adrenergic receptor agonists had little impact on the DMEs in BRL 3A. Our data suggested that CUMS-induced depression might up-regulate DMEs expression via glucocorticoid signaling pathway, and accelerate the fate of the repaglinide in spontaneous diabetes rats. PMID:28574832

Stress-induced endocrine response and anxiety: the effects of comfort food in rats.

PubMed

Ortolani, Daniela; Garcia, Márcia Carvalho; Melo-Thomas, Liana; Spadari-Bratfisch, Regina Celia

2014-05-01

The long-term effects of comfort food in an anxiogenic model of stress have yet to be analyzed. Here, we evaluated behavioral, endocrine and metabolic parameters in rats submitted or not to chronic unpredictable mild stress (CUMS), with access to commercial chow alone or to commercial chow and comfort food. Stress did not alter the preference for comfort food but decreased food intake. In the elevated plus-maze (EPM) test, stressed rats were less likely to enter/remain in the open arms, as well as being more likely to enter/remain in the closed arms, than were control rats, both conditions being more pronounced in the rats given access to comfort food. In the open field test, stress decreased the time spent in the centre, independent of diet; neither stress nor diet affected the number of crossing, rearing or grooming episodes. The stress-induced increase in serum corticosterone was attenuated in rats given access to comfort food. Serum concentration of triglycerides were unaffected by stress or diet, although access to comfort food increased total cholesterol and glucose. It is concluded that CUMS has an anorexigenic effect. Chronic stress and comfort food ingestion induced an anxiogenic profile although comfort food attenuated the endocrine stress response. The present data indicate that the combination of stress and access to comfort food, common aspects of modern life, may constitute a link among stress, feeding behavior and anxiety.

Attenuation of the cyproterone acetate-induced testicular hypofunction by a novel nutraceutical lycopene: a genomic approach.

PubMed

Tripathy, A; Ghosh, A; Dey, A; Pakhira, B P; Ghosh, D

2017-10-01

This study was designed to explore the cyproterone acetate (CPA)-induced andrological hypofunction and its correction by oral administration of lycopene. In this concern, spermatogenic, biochemical, histological and genomic profiles were studied. Cyproterone acetate administration for 1 month helped to develop infertile model rats. A significant recovery was noted in sperm motility, sperm count, sperm viability, hypo-osmotic swelling tail-coiled spermatozoa; activities of testicular ∆ 5 , 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, catalase (CAT) and superoxide dismutase (SOD); and levels of conjugated diene (CD), malondialdehyde (MDA), testicular cholesterol and serum testosterone after the administration of lycopene at 1.5 mg/0.5 ml Tween-80/100 g body weight/day for last 1 month to infertile model rats. Simultaneously, qRT-PCR study of Bax, Bcl-2, caspase-3, ∆ 5 , 3β-HSD and 17β-HSD genes in testicular tissue showed a significant rectification towards the control in CPA-pre-treated cum CPA-lycopene-cotreated rats. Side-by-side histological and histometric studies showed a significant correction in qualitative analysis of spermatogenesis and seminiferous tubular diameter (STD) in CPA-pre-treated cum CPA-lycopene-cotreated rats. Lycopene showed outstanding efficacy in the management of CPA-induced testicular hypofunction with special reference to correction in oxidative stress-induced testicular apoptosis at genomic level. © 2016 Blackwell Verlag GmbH.

The effect of green, black and white tea on the level of alpha and gamma tocopherols in free radical-induced oxidative damage of human red blood cells.

PubMed

Gawlik, Małgorzata; Czajka, Aneta

2007-01-01

The present study was undertaken to investigate the effect of aqueous tea extracts on lipid peroxidation and alpha and gamma tocopherols concentration in the oxidative damage of human red blood cells (RBC). RBC was taken as the model for study of the oxidative damage was induced by cumene hydroperoxide (cumOOH). The antioxidative property of leaf green tea, leaf and granulate of black tea and white tea at levels 1, 2, 4 g/150 mL of water were evaluated. The correlation was observed between reducing power of tea extract and formation of malondialdehyde--MDA (an indicator of lipid peroxidation) in oxidative damage of RBC. All tea extracts at level of 4 g/150 mL of water significantly decreased concentration of MDA. The extract of green tea in comparison to black and white tea extracts at the same levels seems to be a better protective agent against oxidative stress. The antioxidant synergism between components extracted from leaves of green tea and endogenous alpha tocopherol in the oxidative damage of red blood cells was observed. The consumption of alpha tocopherol in oxidative damage of RBC was the lowest after treatment with the highest dose of green tea extract. All tea extracts did not protect against decrease of gamma tocopherol in human erythrocytes treated with cumOOH.

Quasiperiodicity in time evolution of the Bloch vector under the thermal Jaynes-Cummings model

NASA Astrophysics Data System (ADS)

Azuma, Hiroo; Ban, Masashi

2014-07-01

We study a quasiperiodic structure in the time evolution of the Bloch vector, whose dynamics is governed by the thermal Jaynes-Cummings model (JCM). Putting the two-level atom into a certain pure state and the cavity field into a mixed state in thermal equilibrium at initial time, we let the whole system evolve according to the JCM Hamiltonian. During this time evolution, motion of the Bloch vector seems to be in disorder. Because of the thermal photon distribution, both a norm and a direction of the Bloch vector change hard at random. In this paper, taking a different viewpoint compared with ones that we have been used to, we investigate quasiperiodicity of the Bloch vector’s trajectories. Introducing the concept of the quasiperiodic motion, we can explain the confused behaviour of the system as an intermediate state between periodic and chaotic motions. More specifically, we discuss the following two facts: (1) If we adjust the time interval Δt properly, figures consisting of plotted dots at the constant time interval acquire scale invariance under replacement of Δt by sΔt, where s(>1) is an arbitrary real but not transcendental number. (2) We can compute values of the time variable t, which let |Sz(t)| (the absolute value of the z-component of the Bloch vector) be very small, with the Diophantine approximation (a rational approximation of an irrational number).

Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice

PubMed Central

Liu, Xiao-Long; Luo, Liu; Mu, Rong-Hao; Liu, Bin-Bin; Geng, Di; Liu, Qing; Yi, Li-Tao

2015-01-01

Previous studies have demonstrated that the mammalian target of rapamycin (mTOR) signaling pathway has an important role in ketamine-induced, rapid antidepressant effects despite the acute administration of fluoxetine not affecting mTOR phosphorylation in the brain. However, the effects of long-term fluoxetine treatment on mTOR modulation have not been assessed to date. In the present study, we examined whether fluoxetine, a type of commonly used antidepressant agent, alters mTOR signaling following chronic administration in different brain regions, including the frontal cortex, hippocampus, amygdala and hypothalamus. We also investigated whether fluoxetine enhanced synaptic protein levels in these regions via the activation of the mTOR signaling pathway and its downstream regulators, p70S6K and 4E-BP-1. The results indicated that chronic fluoxetine treatment attenuated the chronic, unpredictable, mild stress (CUMS)-induced mTOR phosphorylation reduction in the hippocampus and amygdala of mice but not in the frontal cortex or the hypothalamus. Moreover, the CUMS-decreased PSD-95 and synapsin I levels were reversed by fluoxetine, and these effects were blocked by rapamycin only in the hippocampus. In conclusion, our findings suggest that chronic treatment with fluoxetine can induce synaptic protein expression by activating the mTOR signaling pathway in a region-dependent manner and mainly in the hippocampus. PMID:26522512

High-resolution gamma ray attenuation density measurements on mining exploration drill cores, including cut cores

NASA Astrophysics Data System (ADS)

Ross, P.-S.; Bourke, A.

2017-01-01

Physical property measurements are increasingly important in mining exploration. For density determinations on rocks, one method applicable on exploration drill cores relies on gamma ray attenuation. This non-destructive method is ideal because each measurement takes only 10 s, making it suitable for high-resolution logging. However calibration has been problematic. In this paper we present new empirical, site-specific correction equations for whole NQ and BQ cores. The corrections force back the gamma densities to the "true" values established by the immersion method. For the NQ core caliber, the density range extends to high values (massive pyrite, 5 g/cm3) and the correction is thought to be very robust. We also present additional empirical correction factors for cut cores which take into account the missing material. These "cut core correction factors", which are not site-specific, were established by making gamma density measurements on truncated aluminum cylinders of various residual thicknesses. Finally we show two examples of application for the Abitibi Greenstone Belt in Canada. The gamma ray attenuation measurement system is part of a multi-sensor core logger which also determines magnetic susceptibility, geochemistry and mineralogy on rock cores, and performs line-scan imaging.

Synchronization between uncertain nonidentical networks with quantum chaotic behavior

NASA Astrophysics Data System (ADS)

Li, Wenlin; Li, Chong; Song, Heshan

2016-11-01

Synchronization between uncertain nonidentical networks with quantum chaotic behavior is researched. The identification laws of unknown parameters in state equations of network nodes, the adaptive laws of configuration matrix elements and outer coupling strengths are determined based on Lyapunov theorem. The conditions of realizing synchronization between uncertain nonidentical networks are discussed and obtained. Further, Jaynes-Cummings model in physics are taken as the nodes of two networks and simulation results show that the synchronization performance between networks is very stable.

VizieR Online Data Catalog: Chemical analysis of CH stars. II. (Karinkuzhi+, 2015)

NASA Astrophysics Data System (ADS)

Karinkuzhi, D.; Goswami, A.

2017-10-01

Low-resolution spectra of these objects obtained from 2m Himalayan Chandra Telescope at the Indian Astronomical Observatory, Hanle using HFOSC clearly show strong features due to carbon. HFOSC is an optical imager cum spectrograph for conducting low- and medium-resolution grism spectroscopy (http://www.iiap.res.in/iao/hfosc.html). High-resolution spectra necessary for abundance analyses of the programme stars are taken from the ELODIE archive (Moultaka et al. 2004PASP..116..693M). (7 data files).

Separation of variables in anisotropic models: anisotropic Rabi and elliptic Gaudin model in an external magnetic field

NASA Astrophysics Data System (ADS)

Skrypnyk, T.

2017-08-01

We study the problem of separation of variables for classical integrable Hamiltonian systems governed by non-skew-symmetric non-dynamical so(3)\\otimes so(3) -valued elliptic r-matrices with spectral parameters. We consider several examples of such models, and perform separation of variables for classical anisotropic one- and two-spin Gaudin-type models in an external magnetic field, and for Jaynes-Cummings-Dicke-type models without the rotating wave approximation.

Translations on Environmental Quality, Number 169

DTIC Science & Technology

1978-06-28

purified water to polluted streams. This is like adding clean water to dirty dish water. The water is improved, but it cannot be used again." The CUM...disturbed by heavy nitrogen and phosphate compound burdens on the water, a clarification plants was built first to impede the further introduction of...a pair of shoes and socks , some trousers, 3 boy’s shirts and a pair of child’s shorts. The Aboobar Kara firm gave 50 contos; the Zambezia Footwear

Minimizing medical litigation, part 2.

PubMed

Harold, Tan Keng Boon

2006-01-01

Provider-patient disputes are inevitable in the healthcare sector. Healthcare providers and regulators should recognize this and plan opportunities to enforce alternative dispute resolution (ADR) a early as possible in the care delivery process. Negotiation is often the main dispute resolution method used by local healthcare providers, failing which litigation would usually follow. The role of mediation in resolving malpractice disputes has been minimal. Healthcare providers, administrators, and regulators should therefore look toward a post-event communication-cum-mediation framework as the key national strategy to resolving malpractice disputes.

T sub 1-echo sequence: Protecting the State of a Qubit in the Presence of Coherent Interaction

DTIC Science & Technology

2012-09-25

memory is at energy m, and they are coupled with a coupling strength v⊥. We write the coupling in the rotating - wave approximation , assuming q,m...important for the time evolution. In the validity range of the rotating - wave approximation , the above Hamiltonian preserves the total number of...excited state) in total is involved in the dynamics, the underlying Jaynes - Cummings Hamiltonian will lead to the same results as the ones presented here

Integrable Time-Dependent Quantum Hamiltonians

NASA Astrophysics Data System (ADS)

Sinitsyn, Nikolai A.; Yuzbashyan, Emil A.; Chernyak, Vladimir Y.; Patra, Aniket; Sun, Chen

2018-05-01

We formulate a set of conditions under which the nonstationary Schrödinger equation with a time-dependent Hamiltonian is exactly solvable analytically. The main requirement is the existence of a non-Abelian gauge field with zero curvature in the space of system parameters. Known solvable multistate Landau-Zener models satisfy these conditions. Our method provides a strategy to incorporate time dependence into various quantum integrable models while maintaining their integrability. We also validate some prior conjectures, including the solution of the driven generalized Tavis-Cummings model.

SGR 1822-1606 (Swift J1822.3-1606): X-ray spectrum and refined spin period from Swift XRT analysis

NASA Astrophysics Data System (ADS)

Esposito, P.; Rea, N.; Israel, G. L.

2011-07-01

We have analysed 1.6 ks s of Photon Counting (PC) XRT data of the new SGR/magnetar candidate Swift J1822.3-1606 (Cummings et al. GCN #12159), including the first 0.6 ks on which Pagani et al. reported in GCN #12163. We found that the source spectrum is well described by a power-law plus blackbody model, modified for the interstellar absorption (reduced chi-squared = 1.04 for 97 degrees of freedom).

Swift J1822.3-1606: pre-outburst ROSAT limits (plus erratum)

NASA Astrophysics Data System (ADS)

Esposito, P.; Rea, N.; Israel, G. L.; Tieng, A.

2011-07-01

We report on a pre-outburst ROSAT PSPC observation of the new SGR discovered by Swift-BAT on 2011 July 14 (Cummings et al. Atel #3488). The PSPC observation was performed on 1993 September 12 for ~6.7ks. We find a source at: RA (2000) = 18 22 18.1 and Dec (2000)= -16 04 26.4, with a 5sigma detection significance. The count-rate (corrected for the PSPC PSF, sampling dead time, and vignetting) is about 0.012 counts/s.

LEAD AND MERCURY EACH AS PRIME MATTER IN ALCHEMY

PubMed Central

Mahdihassan, S.

1988-01-01

Prime Matter is matter-cum-energy. The first substance identified as such was lead. When gently heated it becomes red and redness means soul or energy so that lead was potentially red or soul-like and as such dual natured. Mercury also becomes red and can return to white metal. It was thus dual natured and was the second substance recognized as Prime Matter. First lead alone and then lead and mercury were considered as the source of all metals. PMID:22557603

Quantum Speed Limit of a Photon under Non-Markovian Dynamics

NASA Astrophysics Data System (ADS)

Xu, Zhen-Yu; Zhu, Shi-Qun

2014-02-01

Quantum speed limit (QSL) time under noise has drawn considerable attention in real quantum computational processes. Though non-Markovian noise is found to be able to accelerate quantum evolution for a damped Jaynes—Cummings model, in this work we show that non-Markovianity will slow down the quantum evolution of an experimentally controllable photon system. As an application, QSL time of a photon can be controlled by regulating the relevant environment parameter properly, which nearly reaches the currently available photonic experimental technology.

In Situ Warming and Soil Venting to Enhance the Biodegradation of JP-4 in Cold Climates: A Critical Study and Analysis

DTIC Science & Technology

1995-12-01

1178-1180 (1991). Atlas , Ronald M. and Richard Bartha . Microbial Ecology : Fundamentals and Applications. 3d ed. Redwood City CA: The Benjamin/Cummings...technique called bioventing. In cold climates, in situ bioremediation is limited to the summer when soil temperatures are sufficient to support microbial ...actively warmed the soil -- warm water circulation and heat tape; the other passively warmed the plot with insulatory covers. Microbial respiration (02

Improved diode performance of Ag nanoparticle dispersed Er doped In2O3 film

NASA Astrophysics Data System (ADS)

Ghosh, Anupam; Dwivedi, Shyam Murli Manohar Dhar; Chakrabartty, Shubhro; Mondal, Aniruddha

2018-04-01

Ag nanoparticle(NP) dispersedEr doped In2O3 film was prepared by sol-gel method followed by thermal evaporation cum glancing angle deposition technique. The Schottky contact based devicecontaining Ag NPs shows ideality factor of ˜180 at 10 K and ˜5 at 300 K, which is lesser as compared to the device that does not contain Ag NPs. The lower ideality factor value all over the temperature range makes the diode more reliable.

Satellite-On-A-Chip Feasibility for Distributed Space Missions

DTIC Science & Technology

2006-07-10

S.pdf Satellite Systems Conference and Exhibit, Monterey, [33] H . Helvajian and S. W. Janson, "The Fabrication of a CA, 2004, Paper AIAA-2004-3152. 100...pp. 12-15. 700. [52]0. Yadid-Pecht and R. Etienne-Cummings, CMOS [64]S. W. Janson, H . Helvajian , S. Amimoto, G. Smit, D. Imagers: From...Janson, H . Helvajian , and K. Breuer "MEMS, Hasler, "A 80 p W/frame 104x128 CMOS Imager Microengineering and Aerospace Systems," in Proc. Front End for

As Parents Go, So Go the Children. The Development and Adjustment of Children in the Military.

DTIC Science & Technology

1981-06-15

efforts are at least a beginning by the military to assume some responsibility in manag - ing the child abuse problems occurring within its ranks. Families ...the family (Allen, 1975). Treatment and prevention of child abuse and neglect in mili- tary families is promoted most effectively when it is managed ...and Management and Department of Psychology Dr. Larry Cummings College Park MD 20742 University of Wisconsin-Madison Graduate School of Business Dr. D

Effects of the Stark Shift on the Evolution of the Field Entropy and Entanglement in the Two-Photon Jaynes-Cummings Model

NASA Technical Reports Server (NTRS)

Fang, Mao Fa

1996-01-01

The evolution of the field entropy in the two-photon JCM in the presence of the Stark shift is investigated, and the effects of the dynamic Stark shift on the evolution of the field entropy and entanglement between the atom and field, are examined. The results show that the dynamic Stark shift plays an important role in the evolution of the field entropy in two-photon processes.

U.S. Intelligence: Compliance with the Intelligence Reform and Terrorism Prevention Act of 2004 and the 9/11 Commission Report Recommendations

DTIC Science & Technology

2006-05-26

pertinent documents. In a Congressional Research Service (CRS) report to Congress dated April 11, 2005 Richard Best, Alfred Cummings and Todd Masse...Members of the 9/11 Commission16 Thomas H. Kean, Chair Lee H. Hamilton, Vice Chair Richard Ben-Veniste Fred F. Fielding Jamie S. Gorelick Slade Gorton Bob...closely monitor worksites. 109 51 Richard L. Skinner, Inspector General of the Department of Homeland Security, provided Congress a comprehensive and

Mars Curiosity mission

NASA Image and Video Library

2012-08-04

NASA welcomed hundreds of children and accompanying adults to its INFINITY visitor center on Aug. 4, offering Mars-related activities that focused attention on the space agency's Curiosity mission to the Red Planet. Parents and children, such as Myron and Trey (age 3) Cummings, enjoyed exploring Mars using an interactive touch table (top right photo). Midway through the day of activities, visitors in the Science on a Sphere auditorium also enjoyed a presentation on Mars and the Curiosity mission by Dr. Steven Williams, a NASA expert on Mars.

Mars Curiosity mission

NASA Image and Video Library

2012-08-04

NASA welcomed hundreds of children and accompanying adults to its INFINITY visitor center on Aug. 4, offering Mars-related activities that focused attention on the space agency's Curiosity mission to the Red Planet. Parents and children, such as Myron and Trey (age 3) Cummings, enjoyed exploring Mars using an interactive touch table. Midway through the day of activities, visitors in the Science on a Sphere auditorium also enjoyed a presentation on Mars and the Curiosity mission by Dr. Steven Williams, a NASA expert on Mars.

Assisted Dying in Canada.

PubMed

Schuklenk, Udo

This paper makes an affirmative ethical case in favour of the decriminalization of assisted dying in Canada. It then proceeds to defending the affirmative case against various slippery-slope arguments that are typically deployed by opponents of assisted dying. Finally, a recent case of questionable professional conduct by anti-euthanasia campaigners cum academics is flagged as a warning to all of us not to permit the quality of the professional debate to deteriorate unacceptably, despite the personal emotional investments involved on all sides of the debate.

PNPN Latchup in Bipolar LSI Devices.

DTIC Science & Technology

1982-01-01

6611, J. Ritter ATTN: STEWS -TE-N, T. Arellanes ATTN: Code 6612, G. McLane ATTN: STEWS -TE-AN, R. Dutchover ATTN: Code 6816, H. Hughes ATTN: STEWS -TE...AN, R. Hays ATTN: Code 6653, A. Namenson * ATTN: STEWS -TE-N, K. Cummings ATTN: Code 6611, L. August ATTN: STEWS -TE-NT, M. Squires ATTN: Code 6813, J...Killiany ATTN: STEWS -TE-AN, J. Meason ATTN: Code 6600, J. Schriempf ATTN: STEWS -TE-AN, A. De La Paz ATTN: Code 6610, R. Marlow USA MATTN: Code 2627USA

Pyrite deformation and connections to gold mobility: insight from micro-structural analysis and trace element mapping

NASA Astrophysics Data System (ADS)

Dubosq, Renelle; Rogowitz, Anna; Lawley, Christopher; Schneider, David; Jackson, Simon

2017-04-01

Pyrite is an important and ubiquitous gold-bearing phase in many orogenic gold deposits making the study of its deformation behaviour under metamorphic conditions crucial to the understanding of gold (re)mobilization. However, pyrite deformation mechanisms and their influence on the retention or release of trace elements during deformation and metamorphism remain poorly understood. We propose a syn- to post-peak metamorphic and deformation driven gold upgrading model where gold is remobilized through deformation-induced diffusion pathways in the form of substructures in pyrite. The middle amphibolite facies assemblage (actinolite-biotite-plagioclase-almandine) of the Detour Lake deposit (Canada) makes it an ideal study area due to maximum temperatures reaching 550°C, exceeding the conditions for plastic deformation in pyrite (450°C). The world-class Detour Lake deposit, containing 16.4 Moz of Au at 1 g/t, is a Neoarchean orogenic gold ore body located in the northern Abitibi district within the Superior Province. The mine is situated along the high strain, sub-vertical ductile-brittle Sunday Lake Deformation Zone (SLDZ) parallel to the broadly E-W trending Abitibi greenstone belt. Herein we combine orientation contrast (OC) forescatter imaging, electron backscatter diffraction (EBSD) and 2D laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) trace element pyrite mapping to evaluate the influence of pyrite brittle and plastic deformation on the release of trace elements during syn-metamorphic gold remobilization. Local misorientation patterns in pyrite exhibit parallel bands that can be described by continuous rotation around one of the <100> axes, whereas higher strain areas reveal more heterogeneous misorientation patterns and the development of low-angle grain boundaries with late fractures indicative of dislocation creep and strain hardening. These late fractures are an important micro-structural setting for gold and clusters of precious-metal mineral inclusions (telluride minerals). Minor recrystallization processes can also be observed along phase boundaries between pyrite and more competent amphibole crystals. LA-ICP-MS trace element maps document primary, syn-metamorphic oscillatory zoning of some chalcophile and siderophile elements during crystallization of pyrite porphyroblasts. These primary pyrite features are cut by late metal-rich fractures suggesting that remobilization of gold occurred with trace element enrichment of other chalcophile and siderophile elements (Cu, Pb, Zn, Ag, Bi, Te), which post-dates the main period of syn-metamorphic pyrite crystallization at the margins of pre- to syn-deformation, high-grade gold veins. Pyrite grain boundaries and subgrains are also base and precious metal rich, suggesting that late gold remobilization also occurred during pyrite recrystallization. Additional trace element mapping will help determine to what extent pyrite plastic deformation facilitates the diffusion of gold and other trace elements during gold precipitation and remobilization, which, in turn, will inform the source to sink pathways of ore deposition.

Deglaciation of the James Bay Lowlands and Northern Abitibi: Insights on Late-Glacial Ice Readvances and Drainage of Glacial Lake Ojibway

NASA Astrophysics Data System (ADS)

Roy, M.; Veillette, J. J.; Dell'Oste, F.

2008-12-01

Deglaciation in the James Bay region was marked by the scission of the Laurentide ice sheet margin into the Hudson dome to the west and the New-Quebec dome to the east, which subsequently retreated northward, in contact with the waters of glacial Lake Ojibway. Previous work based on air photo-interpretation and field observations indicate that ice retreat in the region was highly dynamic, with the occurrence of at least three ice readvances into the basin of Lake Objiway prior to the final deglaciation, and the incursion of the post- glacial Tyrrell Sea at ~8 ka (Hardy, 1976). Our investigations of stratigraphic sections exposed along the Harricana, Nottaway, Broadback, and Rupert rivers in the lowlands of Quebec indicate that only part of these events are preserved in these sedimentary sequences. The base of the late-glacial sequence generally consists of a carbonate-bearing clayey readvance till that lies on older tills of the last glacial cycle, or truncate Lake Ojibway glaciolacustrine sediments. None of the sections showed more than one till of the three (Cochrane I, Rupert, Cochrane II) readvances documented in the region. Nonetheless, an extensive Ojibway sequence located just south from the lowlands shows three intervals with significant increases in detrital carbonate and coarsening of the varve sequence that can be linked with these late-glacial surges. In the lowlands, the readvance till is commonly capped by a thick sequence of Ojibway varves. The contact between the glaciolacustrine sediments and the overlying Tyrrell Sea marine deposits is marked by a ~50 cm-thick horizon composed at the bottom of thinly laminated reddish and grey silt beds containing abundant rounded clay balls, overlain by coarser silts and fine sands with disseminated clasts. This horizon is here interpreted to reflect the abrupt drainage of Lake Ojibway. Recent radiocarbon dating of mollusks and foraminifers from the uppermost part of this horizon yielded ages of ~7.7 ka and ~8.0 ka. These results thus identify the James Bay axis as an important pathway through which glacial Lake Ojibway waters drained shortly before the marine incursion. Further south, in the Abitibi region, the flat-lying Ojibway clay plains show former lake shores (wave-cut benches) incised into the glaciolacustrine sediments, thereby suggesting abrupt lowering of the Ojibway lake level (Thibaudeau and Veillette, 2005). Nearby stratigraphic exposures of varved clays contain a ~30-40 cm-thick bed consisting of massive silts and fine sands that also suggests some kind of lowering and drainage of the lake waters. The paleoecological content of these coarser horizons and bounding glaciolacustrine clays are currently being investigated for further analyses and radiocarbon dating. The results should provide additional information on the timing of these low lake levels, and their possible link with the drainage horizon documented in the James Bay lowlands.

What can we learn from the dynamics of entanglement and quantum discord in the Tavis-Cummings model?

NASA Astrophysics Data System (ADS)

Restrepo, Juliana; Rodriguez, Boris A.

We revisit the problem of the dynamics of quantum correlations in the exact Tavis-Cummings model. We show that many of the dynamical features of quantum discord attributed to dissipation are already present in the exact framework and are due to the well known non-linearities in the model and to the choice of initial conditions. Through a comprehensive analysis, supported by explicit analytical calculations, we find that the dynamics of entanglement and quantum discord are far from being trivial or intuitive. In this context, we find states that are indistinguishable from the point of view of entanglement and distinguishable from the point of view of quantum discord, states where the two quantifiers give opposite information and states where they give roughly the same information about correlations at a certain time. Depending on the initial conditions, this model exhibits a fascinating range of phenomena that can be used for experimental purposes such as: Robust states against change of manifold or dissipation, tunable entanglement states and states with a counterintuitive sudden birth as the number of photons increase. We furthermore propose an experiment called quantum discord gates where discord is zero or non-zero depending on the number of photons. This work was supported by the Vicerrectoria de Investigacion of the Universidad Antonio Narino, Colombia under Project Number 20141031 and by the Departamento Administrativo de Ciencia, Tecnologia e Innovacion (COLCIENCIAS) of Colombia under Grant Number.

Grassmann phase space theory and the Jaynes-Cummings model

NASA Astrophysics Data System (ADS)

Dalton, B. J.; Garraway, B. M.; Jeffers, J.; Barnett, S. M.

2013-07-01

The Jaynes-Cummings model of a two-level atom in a single mode cavity is of fundamental importance both in quantum optics and in quantum physics generally, involving the interaction of two simple quantum systems—one fermionic system (the TLA), the other bosonic (the cavity mode). Depending on the initial conditions a variety of interesting effects occur, ranging from ongoing oscillations of the atomic population difference at the Rabi frequency when the atom is excited and the cavity is in an n-photon Fock state, to collapses and revivals of these oscillations starting with the atom unexcited and the cavity mode in a coherent state. The observation of revivals for Rydberg atoms in a high-Q microwave cavity is key experimental evidence for quantisation of the EM field. Theoretical treatments of the Jaynes-Cummings model based on expanding the state vector in terms of products of atomic and n-photon states and deriving coupled equations for the amplitudes are a well-known and simple method for determining the effects. In quantum optics however, the behaviour of the bosonic quantum EM field is often treated using phase space methods, where the bosonic mode annihilation and creation operators are represented by c-number phase space variables, with the density operator represented by a distribution function of these variables. Fokker-Planck equations for the distribution function are obtained, and either used directly to determine quantities of experimental interest or used to develop c-number Langevin equations for stochastic versions of the phase space variables from which experimental quantities are obtained as stochastic averages. Phase space methods have also been developed to include atomic systems, with the atomic spin operators being represented by c-number phase space variables, and distribution functions involving these variables and those for any bosonic modes being shown to satisfy Fokker-Planck equations from which c-number Langevin equations are often developed. However, atomic spin operators satisfy the standard angular momentum commutation rules rather than the commutation rules for bosonic annihilation and creation operators, and are in fact second order combinations of fermionic annihilation and creation operators. Though phase space methods in which the fermionic operators are represented directly by c-number phase space variables have not been successful, the anti-commutation rules for these operators suggest the possibility of using Grassmann variables—which have similar anti-commutation properties. However, in spite of the seminal work by Cahill and Glauber and a few applications, the use of phase space methods in quantum optics to treat fermionic systems by representing fermionic annihilation and creation operators directly by Grassmann phase space variables is rather rare. This paper shows that phase space methods using a positive P type distribution function involving both c-number variables (for the cavity mode) and Grassmann variables (for the TLA) can be used to treat the Jaynes-Cummings model. Although it is a Grassmann function, the distribution function is equivalent to six c-number functions of the two bosonic variables. Experimental quantities are given as bosonic phase space integrals involving the six functions. A Fokker-Planck equation involving both left and right Grassmann differentiations can be obtained for the distribution function, and is equivalent to six coupled equations for the six c-number functions. The approach used involves choosing the canonical form of the (non-unique) positive P distribution function, in which the correspondence rules for the bosonic operators are non-standard and hence the Fokker-Planck equation is also unusual. Initial conditions, such as those above for initially uncorrelated states, are discussed and used to determine the initial distribution function. Transformations to new bosonic variables rotating at the cavity frequency enable the six coupled equations for the new c-number functions-that are also equivalent to the canonical Grassmann distribution function-to be solved analytically, based on an ansatz from an earlier paper by Stenholm. It is then shown that the distribution function is exactly the same as that determined from the well-known solution based on coupled amplitude equations. In quantum-atom optics theories for many atom bosonic and fermionic systems are needed. With large atom numbers, treatments must often take into account many quantum modes—especially for fermions. Generalisations of phase space distribution functions of phase space variables for a few modes to phase space distribution functionals of field functions (which represent the field operators, c-number fields for bosons, Grassmann fields for fermions) are now being developed for large systems. For the fermionic case, the treatment of the simple two mode problem represented by the Jaynes-Cummings model is a useful test case for the future development of phase space Grassmann distribution functional methods for fermionic applications in quantum-atom optics.

Comprehensive spectroscopic studies on the interaction of biomolecules with surfactant detached multi-walled carbon nanotubes.

PubMed

Sekar, Gajalakshmi; Mukherjee, Amitava; Chandrasekaran, Natarajan

2015-04-01

This paper investigates the interaction of ten diverse biomolecules with surfactant detached Multi-Walled Carbon Nanotubes (MWCNTs) using multiple spectroscopic methods. Declining fluorescence intensity of biomolecules in combination with the hyperchromic effect in UV-Visible spectra confirmed the existence of the ground state complex formation. Quenching mechanism remains static and non-fluorescent. 3D spectral data of biomolecules suggested the possibilities of disturbances to the aromatic microenvironment of tryptophan and tyrosine residues arising out of CNTs interaction. Amide band Shifts corresponding to the secondary structure of biomolecules were observed in the of FTIR and FT-Raman spectra. In addition, there exists an increased Raman intensity of tryptophan residues of biomolecules upon interaction with CNTs. Hence, the binding of the aromatic structures of CNTs with the aromatic amino acid residues, in a particular, tryptophan was evidenced. Far UV Circular spectra have showed the loss of alpha-helical contents in biomolecules upon interaction with CNTs. Near UV CD spectra confirmed the alterations in the tryptophan positions of the peptide backbone. Hence, our results have demonstrated that the interaction of biomolecules with OH-MWCNTs would involve binding cum structural changes and alteration to their aromatic micro-environment. Copyright © 2015 Elsevier B.V. All rights reserved.

Fluidized bed coal desulfurization

NASA Technical Reports Server (NTRS)

Ravindram, M.

1983-01-01

Laboratory scale experiments were conducted on two high volatile bituminous coals in a bench scale batch fluidized bed reactor. Chemical pretreatment and posttreatment of coals were tried as a means of enhancing desulfurization. Sequential chlorination and dechlorination cum hydrodesulfurization under modest conditions relative to the water slurry process were found to result in substantial sulfur reductions of about 80%. Sulfur forms as well as proximate and ultimate analyses of the processed coals are included. These studies indicate that a fluidized bed reactor process has considerable potential for being developed into a simple and economic process for coal desulfurization.

Multistate Landau-Zener models with all levels crossing at one point

DOE PAGES

Li, Fuxiang; Sun, Chen; Chernyak, Vladimir Y.; ...

2017-08-04

Within this paper, we discuss common properties and reasons for integrability in the class of multistate Landau-Zener models with all diabatic levels crossing at one point. Exploring the Stokes phenomenon, we show that each previously solved model has a dual one, whose scattering matrix can be also obtained analytically. For applications, we demonstrate how our results can be used to study conversion of molecular into atomic Bose condensates during passage through the Feshbach resonance, and provide purely algebraic solutions of the bowtie and special cases of the driven Tavis-Cummings model.

RFSQUID-Mediated Coherent Tunable Coupling Between a Superconducting Phase Qubit and a Lumped Element Resonator

DTIC Science & Technology

2010-02-02

b). We approximate the Hamiltonian of our system using the Jaynes - Cummings model in the rotating - wave approxima- tion, Ĥ = Ĥq + Ĥr + ĤI(Φx) + Ĥ...when the coupler circulating cur- rent is at the critical current. It is also worth noting that in the limit that c → 1, (Meff )max increases without ...probability is approximately 10%, we can deter- mine the circulating current in the coupler as a function of Φx. Figure 2(a) shows the measured coupler

Quantum many-body correlations in collective phonon-excitations

NASA Astrophysics Data System (ADS)

Droenner, Leon; Kabuss, Julia; Carmele, Alexander

2018-02-01

We present a theoretical study of a many-emitter phonon laser based on optically driven semiconductor quantum dots placed within an acoustic nanocavity. A transformation of the phonon laser Hamiltonian leads to a Tavis-Cummings type interaction with an unexpected additional many-emitter energy shift. This many-emitter interaction with the cavity mode results in a variety of phonon resonances which dependent strongly on the number of participating emitters. These collective resonances show the highest phonon output. Furthermore, we show that the output can be increased even more via lasing at the two phonon resonance.

Mineral resource assessment map of the Big Gum Swamp Roadless Area, Columbia and Baker counties, Florida

USGS Publications Warehouse

Cathcart, J.B.; Cameron, C.C.; Patterson, S.H.

1986-01-01

The geology of the Big Cum Swamp Roadless Area, which is discussed briefly in this report, is covered in somewhat more detail in a report by Patterson, Cathcart, Cameron, and Schruben (1984). The mineral resource potential is quite similar to that in the Natural Area Roadless Area outlined by Cathcart, Patterson and Crandall (1983). The Natural Area, which is east of the eastern boundary of the Big Gum Swamp (fig. 1), also was designated a Wilderness Study Area by Public Law 98-430, September 28, 1984.

Design and Rationale of a Comparative Effectiveness Study to Evaluate Two Acupuncture Methods for the Treatment of Headaches Associated with Traumatic Brain Injury

DTIC Science & Technology

2011-01-01

postoperative dental pain,28,29 postoperative30 and chemotherapy-induced nausea and vomiting,28,29,31,32 idio- pathic headache, and somatic and postoperative...some neurogenic cognitive disorders (e.g., autism ).73 Other studies, moreover, have reported benefit for patients after surgery and head trauma.24,74...children with autism : A pilot study. J Altern Complement Med. 2008;14(2):109–114. 74. Cummings M. Myofascial pain from pectoralis major following trans

Merging Multiple-Partial-Depth Data Time Series Using Objective Empirical Orthogonal Function Fitting

DTIC Science & Technology

2010-05-01

F. J. Lermusiaux, “Adaptive modeling, adaptive data assimilation and adaptive sampling,” Physica D, vol. 230, pp. 172–196, 2007 . [9] T. P. Sapsis and...DOI: 10.1016/j.physd.2009.09.017. [10] P. F. J. Lermusiaux, P. Malanotte-Rizzoli, D. Stammer , J. Carton, J. Cummings, and A. M. Moore, “Progress and...Oceanography, vol. 20, pp. 156–167, 2007 . [12] C. Wunsch, The Ocean Circulation Inverse Problem. Cambridge, U.K.: Cambridge Univ. Press, 1996, ch. 3. [13] H

Swift J1822.3-1606: refined X-ray timing and spectral parameters

NASA Astrophysics Data System (ADS)

Rea, N.; Esposito, P.; Israel, G. L.; Tiengo, A.; Zan, S.

2011-07-01

Between 2011 July 15-19 Swift-XRT continued its monitoring of the new SGR discovered by Swift-BAT, namely Swift J1822.3-1606 (Cummings et al. Atel #3488). Using the first four available Swift-XRT observations we find a best period of 8.437716(5)s. No evidence for a period derivative has been observed in the first days of monitoring, yielding a Pdot limit of about a few 10-10 s/s, still consistent with the SGR nature of this new transient.

The General Aviation Dynamics Model Volume III. Systems Manual.

DTIC Science & Technology

1979-07-01

SEXi and SEX2 or in some other way, as desired by the user. The descriptors of an index are used as stubs (row descriptors) and/or spanners (column...BAR A produces the following plot [7 SUWPLO~TS DATASET A, 1970 TO 1975 8+ .QL xx YXXMX 4+ MXUXX IDLMXX XXXXXX * yyx :mx0(c XXX *m XXXX XX XXXXX XMxK...VXXXCK 2+ mm~ XXXXX MMXXX I~CUM LXXMXx *X2~ XXX xXX =uXX ImXXXLMX * xx Iac lxxno IXxc= )LccIQX * XX= )LXXX ILMKXX X.XXXX IXXCX SHOW

The Subchronic Inhalation Toxicity of DF2 (Diesel Fuel) Used in Vehicle Engine Exhaust Smoke Systems (VEESS).

DTIC Science & Technology

1986-03-01

4-I +4 .- -+ + _C tL+ + + +i + T + +- + - -) 4. c_ --- - * - 4A _ __ _ -- 0 0 ICx" C ) 4j cliou 0 N4cr(\\lc’ + + ++ ++ + + +1 -4++111+ = 0 m x...Charles L. Crouse SP6 David C . Burnett Garnet E. Affleck Dale H. Heitkamp Edmund G. Cummings, Ph.D. Carlyle Lilly Richard L. Farrand, Ph.D. Joseph J...Feeney, Ph.D. Robert W. Dorsey Michael Rausa SP6 Mohammed S. Ghumman Ernest H. Kandel Robert D. Armstrong Jeffrey D. Bergmann William C . Stark. John

Cultural Resource Investigation of the Historic Fort Randall Post Cemetery, Gregory County, South Dakota.

DTIC Science & Technology

1986-01-01

cemetery: LOCATED BY SHOULD BE K GRAVE # GRAVE # Susana , wife of G Rieder 134 137 Died Feb 27, 1892 SINGLE STONE w, - Augustin, Infant Child of G and...134 134 Susana Rieder. Died Aug 3, 1881 Elizabeth A. Carroll 135 135 Jacob Herman 128 128 J.A. Breckenridge (Plate 8) 123 123 Lena, wife of J.F...Inf. June 24, 1859 32. Harting Daniel Pvt. Co. M, 4th U.S. Art. Aug. 1, 1859 33. Cummings, James Pvt. Co. A, Dak. Vols. Apr. 8, 1863 34

Entanglement Evolution of Jaynes-Cummings Model in Resonance Case and Non-resonance Case

NASA Astrophysics Data System (ADS)

Cheng, Jing; Chen, Xi; Shan, Chuan-Jia

2018-06-01

We investigate the entanglement evolution of a two-level atom and a quantized single model electromagnetic filed in the resonance and non-resonance cases. The effects of the initial state, detuning degree, photon number on the entanglement are shown in detail. The results show that the atom-cavity entanglement state appears with periodicity. The increasing of the photon number can make the period of quantum entanglement be shorter. In the non-resonant case, if we choose the suitable initial state the entanglement of atom-cavity can be 1.0

Few-Photon Model of the Optical Emission of Semiconductor Quantum Dots

NASA Astrophysics Data System (ADS)

Richter, Marten; Carmele, Alexander; Sitek, Anna; Knorr, Andreas

2009-08-01

The Jaynes-Cummings model provides a well established theoretical framework for single electron two level systems in a radiation field. Similar exactly solvable models for semiconductor light emitters such as quantum dots dominated by many particle interactions are not known. We access these systems by a generalized cluster expansion, the photon-probability cluster expansion: a reliable approach for few-photon dynamics in many body electron systems. As a first application, we discuss vacuum Rabi oscillations and show that their amplitude determines the number of electrons in the quantum dot.

A Dodecalogue of Basic Didactics from Applications of Abstract Differential Geometry to Quantum Gravity

NASA Astrophysics Data System (ADS)

Raptis, Ioannis

2007-12-01

We summarize the twelve most important in our view novel concepts that have arisen, based on results that have been obtained, from various applications of Abstract Differential Geometry (ADG) to Quantum Gravity (QG). The present document may be used as a concise, yet informal, discursive and peripatetic conceptual guide- cum-terminological glossary to the voluminous technical research literature on the subject. In a bonus section at the end, we dwell on the significance of introducing new conceptual terminology in future QG research by means of ‘poetic language’.

Evidence for hydrous high-MgO melts in the Precambrian

NASA Astrophysics Data System (ADS)

Stone, William E.; Deloule, Etienne; Larson, Michelle S.; Lesher, C. Michael

1997-02-01

Prevailing petrogenetic models for Precambrian high-MgO melts such as komatiites invoke crystallization from nearly anhydrous melts (≪0.5% H2O) generated by partial melting of mantle peridotite at temperatures of (≤ 1900 °C and pressures of (18 GPa. However, ultramafic cumulate and gabbro zones of komatiitic and other high-MgO units in Precambrian greenstone belts contain vesicles and minor to major amounts (≤ 25%) of igneous amphibole. The textures (oikocrysts, rims on intercumulate pyroxene, and mineral inclusions within orthocumulate olivine) and the water-rich compositions (1.00% 2.50% H2O) of igneous amphiboles from the Archean Abitibi belt indicate crystallization in situ from significantly hydrous melts while the melt fraction was still as high as 40% 50%. Comparisons to experimental phase equilibria suggest that the residual melts from which the amphiboles crystallized contained 3% 4% H2O, and adjustments for fractional crystallization suggest that the initial melts may have contained as much as 2% H2O. H2O contents of this magnitude would require substantial revision of the nearly anhydrous models for Precambrian high-MgO melts, possibly permitting generation at lower temperatures and pressures, lowering their densities and viscosities, increasing their eruptibility, and enhancing the formation of spinifex textures.

Structural, microstructural and electrochemical properties of dispersed-type polymer nanocomposite films

NASA Astrophysics Data System (ADS)

Arya, Anil; Sharma, A. L.

2018-01-01

Free-standing solid polymer nanocomposite (PEO-PVC)  +  LiPF6-TiO2 films have been prepared through a standard solution-cast technique. The improvement in structural, microstructural and electrochemical properties has been observed on the dispersion of nanofiller in polymer salt complex. X-ray diffraction studies clearly reflect the formation of complex formation, as no corresponding salt peak appeared in the diffractograms. The Fourier transform infrared analysis suggested clear and convincing evidence of polymer-ion, ion-ion and polymer-ion-nanofiller interaction. The highest ionic conductivity of the prepared solid polymer electrolyte (SPE) films is ~5  ×  10-5 S cm-1 for 7 wt.% TiO2. The linear sweep voltammetry provides the electrochemical stability window of the prepared SPE films, about ~3.5 V. The ion transference number has been estimated, t ion  =  0.99 through the DC polarization technique. Dielectric spectroscopic studies were performed to understand the ion transport process in polymer electrolytes. All solid polymer electrolytes possess good thermal stability up to 300 °C. Differential scanning calorimetry analysis confirms the decrease of the melting temperature and signal of glass transition temperature with the addition of nanofiller, which indicates the decrease of crystallinity of the polymer matrix. An absolute correlation between diffusion coefficient (D), ion mobility (µ), number density (n), double-layer capacitance (C dl), glass transition temperature, melting temperature (T m), free ion area (%) and conductivity (σ) has been observed. A convincing model to study the role of nanofiller in a polymer salt complex has been proposed, which supports the experimental findings. The prepared polymer electrolyte system with significant ionic conductivity, high ionic transference number, and good thermal and voltage stability could be suggested as a potential candidate as electrolyte cum separator for the fabrication of a rechargeable lithium-ion battery system.

Arbitrary Dicke-State Control of Symmetric Rydberg Ensembles

NASA Astrophysics Data System (ADS)

Deutsch, Ivan

2017-04-01

We study the production of arbitrary superpositions of Dicke states via optimal control. We show that N atomic hyperfine qubits, interacting symmetrically via the Rydberg blockade, are well described by the Jaynes-Cummings Model (JCM), familiar in cavity QED. In this isomorphism, the presence or absence of a collective Rydberg excitation plays the role of the two-level system and the number of symmetric excitations of the hyperfine qubits plays the role of the bosonic excitations of the JCM. This system is fully controllable through the addition of phase-modulated microwaves that drive transitions between the Rydberg-dressed states. In the weak dressing regime, this results in a single-axis twisting Hamiltonian, plus time-dependent rotations of the collective spin. For strong dressing we control the entire Jaynes-Cummings ladder. Using optimal control, we design microwave waveforms that can generate arbitrary states in the symmetric subspace. This includes cat states, Dicke states, and spin squeezed states. With currently feasible parameters, it is possible to generate arbitrary symmetric states of _10 hyperfine qubits in 1 microsec, assuming a fast microwave phase switching time. The same control can be achieved with a ``dressed-ground control'' scheme, which reduces the demands for fast phase switching at the expense of increased total control time. More generally, we can achieve control on larger ensembles of qubits by designing waveforms that are bandwidth limited within the coherence time of the system. We use this to study general questions of the ``quantum speed limit'' and information content in a waveform that is needed to generate arbitrary quantum states.

Effects of marital conflict on children: recent advances and emerging themes in process-oriented research.

PubMed

Cummings, E Mark; Davies, Patrick T

2002-01-01

The effects of marital conflict on children's adjustment are well documented. For the past decade research has increasingly focused on advancing a process-level understanding of these effects, that is, accounting for the particular responses and patterns embedded within specific contexts, histories, and developmental periods that account for children's outcomes over time. As a vehicle for presenting an update, this review follows the framework for process-oriented research initially proposed by Cummings and Cummings (1988), concentrating on recent research developments, and also considering new and emerging themes in this area of research. In this regard, areas of advancement include (a) greater articulation of the effects of specific context/stimulus characteristics of marital conflict, (b) progress in identifying the psychological response processes in children (e.g., cognitive, emotional, social, physiological) that are affected and their possible role in accounting for relations between marital conflict and child outcomes, (c) greater understanding of the role of child characteristics, family history, and other contextual factors, including effects on children due to interrelations between marital conflict and parenting, and (d) advances in the conceptualization of children's outcomes, including that effects may be more productively viewed as dynamic processes of functioning rather than simply clinical diagnoses. Understanding of the impact of marital conflict on children as a function of time-related processes remains a gap in a process-oriented conceptualization of effects. Based on this review, a revised model for a process-oriented approach on the effects of marital discord on children is proposed and suggestions are made for future research directions.

Low energy ion beam dynamics of NANOGAN ECR ion source

NASA Astrophysics Data System (ADS)

Kumar, Sarvesh; Mandal, A.

2016-04-01

A new low energy ion beam facility (LEIBF) has been developed for providing the mass analyzed highly charged intense ion beams of energy ranging from a few tens of keV to a few MeV for atomic, molecular and materials sciences research. The new facility consists of an all permanent magnet 10 GHz electron cyclotron resonance (ECR) ion source (NANOGAN) installed on a high voltage platform (400 kV) which provides large currents of multiply charged ion beams. Higher emittance at low energy of intense ion beam puts a tremendous challenge to the beam optical design of this facility. The beam line consists of mainly the electrostatic quadrupoles, an accelerating section, analyzing cum switching magnet and suitable beam diagnostics including vacuum components. The accelerated ion beam is analyzed for a particular mass to charge (m/q) ratio as well as guided to three different lines along 75°, 90° and 105° using a large acceptance analyzing cum switching magnet. The details of transverse beam optics to all the beam lines with TRANSPORT and GICOSY beam optics codes are being described. Field computation code, OPERA 3D has been utilized to design the magnets and electrostatic quadrupoles. A theoretical estimation of emittance for optimized geometry of ion source is given so as to form the basis of beam optics calculations. The method of quadrupole scan of the beam is used to characterize the emittance of the final beam on the target. The measured beam emittance increases with m/q ratios of various ion beams similar to the trend observed theoretically.

BDNF–ERK–CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice

PubMed Central

Yi, Li-Tao; Li, Jing; Liu, Bin-Bin; Luo, Liu; Liu, Qing; Geng, Di

2014-01-01

Background Although previous study has demonstrated that brain-derived neurotrophic factor (BDNF) is involved in the antidepressant-like effect of oleanolic acid, there is little information regarding the details of the molecular mechanism involved in this effect. Methods We used a chronic unpredictable mild stress (CUMS) model to test the antidepressant-like effect of oleanolic acid on depressant-like behaviour, miR-132 expression and synaptic protein expression in the male mouse hippocampus. Furthermore, we explored the possible signalling pathways associated with miR-132 expression that mediate the effect of oleanolic acid on neuronal proliferation. Results The results demonstrated that a 3-week treatment with oleanolic acid ameliorated CUMS-induced anhedonic and anxiogenic behaviours. Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation. Moreover, experiments with an miR-132 antagomir revealed that targeting miR-132 led to inhibition of neuronal proliferation and the postsynaptic density protein 95, but did not affect presynaptic protein synapsin I. Limitations Several other stimuli can also induce CREB phosphorylation in the hippocampus. Thus, regulation of miR-132 may not be restricted to neurotrophic signalling. Conclusion Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF–ERK–CREB signalling pathways. PMID:25079084

Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress.

PubMed

Jin, Peng; Yu, Hai-Ling; Tian-Lan; Zhang, Feng; Quan, Zhe-Shan

2015-06-01

Oleoylethanolamide (OEA) is an endocannabinoid analog that belongs to a family of endogenous acylethanolamides. Increasing evidence suggests that OEA may act as an endogenous neuroprotective factor and participate in the control of mental disorder-related behaviors. In this study, we examined whether OEA is effective against depression and investigated the role of circulating endogenous acylethanolamides during stress. Mice were subjected to 28days of chronic unpredictable mild stress (CUMS), and during the last 21days, treated with oral OEA (1.5-6mg/kg) or 6mg/kg fluoxetine. Sucrose preference and open field test activity were used to evaluate depression-like behaviors during CUMS and after OEA treatment. Weights of the prefrontal cortex and hippocampus were determined, and the adrenal index was measured. Furthermore, changes in serum adrenocorticotropic hormone (ACTH), corticosterone (CORT) and total antioxidant capacity (T-AOC), brain-derived neurotrophic factor (BDNF), and lipid peroxidation product malondialdehyde (MDA) levels, and superoxide dismutase (SOD) activities in the hippocampus and prefrontal cortex were detected. Our findings indicate that OEA normalized sucrose preferences, locomotion distances, rearing frequencies, prefrontal cortex and hippocampal atrophy, and adrenal indices. In addition, OEA reversed the abnormalities of BDNF and MDA levels and SOD activities in the hippocampus and prefrontal cortex, as well as changes in serum levels of ACTH, CORT, and T-AOC. The antidepressant effects of OEA may be related to the regulation of BDNF levels in the hippocampus and prefrontal cortex, antioxidant defenses, and normalizing hyperactivity in the hypothalamic-pituitary-adrenal axis (HPA). Copyright © 2015 Elsevier Inc. All rights reserved.

Chronology of early Archaean granite-greenstone evolution in the Barberton Mountain Land, South Africa, based on precise dating by single zircon evaporation.

PubMed

Krüner, A; Byerly, G R; Lowe, D R

1991-04-01

We report precise 207Pb/206Pb single zircon evaporation ages for low-grade felsic metavolcanic rocks within the Onverwacht and Fig Tree Groups of the Barberton Greenstone Belt (BGB), South Africa, and from granitoid plutons bordering the belt. Dacitic tuffs of the Hooggenoeg Formation in the upper part of the Onverwacht Group yield ages between 3445 +/- 3 and 3416 +/- 5 Ma and contain older crustal components represented by a 3504 +/- 4 Ma old zircon xenocryst. Fig Tree dacitic tuffs and agglomerates have euhedral zircons between 3259 +/- 5 and 3225 +/- 3 Ma in age which we interpret to reflect the time of crystallization. A surprisingly complex xenocryst population in one sample documents ages from 3323 +/- 4 to 3522 +/- 4 Ma. We suspect that these xenocrysts were inherited, during the passage of the felsic melts to the surface, from various sources such as greenstones and granitoid rocks now exposed in the form of tonalite-trondhjemite plutons along the southern and western margins of the BGB, and units predating any of the exposed greenstone or intrusive rocks. Several of the granitoids along the southern margin of the belt have zircon populations with ages between 3490 and 3440 Ma. coeval with or slightly older than Onverwacht felsic volcanism, while the Kaap Valley pluton along the northwestern margin of the belt is coeval with Fig Tree dacitic volcanism. These results emphasize the comagmatic relationships between greenstone felsic volcanic units and the surrounding plutonic suites. Some of the volcanic plutonic units contain zircon xenocrysts older than any exposed rocks. These indicate the existence of still older units, possibly stratigraphically lower and older portions of the greenstone sequence itself, older granitoid intrusive rocks, or bodies of older, unrelated crustal material. Our data show that the Onverwacht and Fig Tree felsic units have distinctly different ages and therefore do not represent a single, tectonically repeated unit as proposed by others. Unlike the late Archaean Abitibi greenstone belt in Canada, which formed over about 30 Ma. exposed rocks in the BGB formed over a period of at least 220 Ma. The complex zircon populations encountered in this study imply that conventional multigrain zircon dating may not accurately identify the time of felsic volcanic activity in ancient greenstones. A surprising similarity in rock types, tectonic evolution, and ages of the BGB in the Kaapvaal craton of southern Africa and greenstones in the Pilbara Block of Western Australia suggests that these two terrains may have been part of a larger crustal unit in early Archaean times.

Evaluation of Tests for Determining the Pumpability of Concrete Mixtures.

DTIC Science & Technology

1981-10-01

mixture No. 4 21 MIXTURE NO. 5 (Pumped) CHARACTERISTIC DESIRED RANGE ACTUALI NG ? OKIADJUSLTHENT CA/TARATIO50% LI.RGER MSA CA/T RATUMO TO IMORE RD AGG 65 ...CA/TA RATIO TO MORE RD AGG (BY VOLUME) 65 % LOW FM OF FA 50%. N. WT. 2.4 - . FM OF FA LT". . -- - #k0 SIEVE 15-30% 18 X CUM 7 FA PASSI ___ IVE 5 --, T...Chief of Engineers, U. S. Army EL E C LU Washington, D. C. 20314 S L~w Under CWIS Work Unit 31138 D -34 Destroy this report when no longer needed. Do

Water Resources Research supports water economics submissions

NASA Astrophysics Data System (ADS)

Griffin, Ronald C.

2012-09-01

AGU's international interdisciplinary journal Water Resources Research (WRR) publishes original contributions in hydrology; the physical, chemical, and biological sciences; and the social and policy sciences, including economics, systems analysis, sociology, and law. With the rising relevance of water economics and related social sciences, the editors of WRR continue to encourage submissions on economics and policy. WRR was originally founded in the mid 1960s by Walter Langbein and economist Allen Kneese. Several former WRR editors have been economists—including David Brookshire, Ron Cummings, and Chuck Howe—and many landmark articles in water economics have been published in WRR.

THE SINO-INDIAN ORIGIN OF CHEMEIA AND CHUMEIA AS SYNONYMS IN GREK, SIGNIFYING ALCHEMY

PubMed Central

Mahdihassan, S.

1984-01-01

In China the antecedent of alchemy is represented by the god of longevity emerging from the peach. The first synthetic drug, Kim-Yeh, red colloidal gold, signified gold-cum -herbal juice. Kim-Yeh=Kimiya (Arabic) =chemeia (Greek). Translated this gave Chrusozomion=Gold Ferment, specifying the drug. Rasayana was translated as Chumeia, herbal juice-incorporate and signified the art alchemy. Chemeia was Chinese and Chumeia, Indian. Originally each signified both, a drug of longevity and the art, alchemy. Finally the art of making red gold was misunderstood as the art of making gold itself PMID:22557463

Contemporary Records of the (1492) Ensisheim Fall

NASA Astrophysics Data System (ADS)

Levi, F. A.; Levi-Donati, G. R.

1992-07-01

On the occasion of the five-hundredth anniversary of the Ensisheim (LL6) stone (November 16, 1492), five rare documents on this fall are presented: 1) Anonymous, Annali del Convento di S. Domenico. (in Italian) Manuscript n. 1151, Biblioteca Com. "Augusta", Perugia. 2) Eusebii Pamphili C. (1570) Chronicon. Petri, Basilea. (in Latin). 3) Lycosthenes (Wolffhart) C. (1557) Prodigiorum ac ostentorum Chronicon. Petri, Basilea. (in Latin). 4) Sansovino F. (1582) Cronologia del Mondo. Salicato, Vinegia. (in Italian). 5) Schedel H. (1492) Liber Chronicarum cum figuris et ymagi(ni)bus ab inicio mu(n)di. Koberger, Nuremberga. (in Latin).

[Regimento proueytoso and Modus curandi: edition of the texts].

PubMed

Rosa, Maria Carlota; de Carvalho, Diana Maul; Teixeira, Dante Martins

2005-01-01

This issue features facsimiles of Regimento proueytoso contra ha pestenença and Modus curandi cum balsamo, based on the original texts housed in the Biblioteca Pública de Evora and the Biblioteca Nacional de Portugal, respectively. Semi-diplomatic editions of both facsimiles--with transliterations into modern characters--have also been provided. These are followed by translations, in the case of Regimento from old to modern Portuguese and in the case of Modus curandi from Latin to modern-day Portuguese. This text explains the criteria used in preparing the semi-diplomatic versions and in modernizing the text of Regimento.

On the paradoxical evolution of the number of photons in a new model of interpolating Hamiltonians

NASA Astrophysics Data System (ADS)

Valverde, Clodoaldo; Baseia, Basílio

2018-01-01

We introduce a new Hamiltonian model which interpolates between the Jaynes-Cummings model (JCM) and other types of such Hamiltonians. It works with two interpolating parameters, rather than one as traditional. Taking advantage of this greater degree of freedom, we can perform continuous interpolation between the various types of these Hamiltonians. As applications, we discuss a paradox raised in literature and compare the time evolution of the photon statistics obtained in the various interpolating models. The role played by the average excitation in these comparisons is also highlighted.

Variational method for nonconservative field theories: Formulation and two PT-symmetric case examples

NASA Astrophysics Data System (ADS)

Restrepo, Juan; Ciuti, Cristiano; Favero, Ivan

2014-01-01

This Letter investigates a hybrid quantum system combining cavity quantum electrodynamics and optomechanics. The Hamiltonian problem of a photon mode coupled to a two-level atom via a Jaynes-Cummings coupling and to a mechanical mode via radiation pressure coupling is solved analytically. The atom-cavity polariton number operator commutes with the total Hamiltonian leading to an exact description in terms of tripartite atom-cavity-mechanics polarons. We demonstrate the possibility to obtain cooling of mechanical motion at the single-polariton level and describe the peculiar quantum statistics of phonons in such an unconventional regime.

The Generation of Field Sensitive Interface States in Commercial CMOS Devices.

DTIC Science & Technology

1984-05-31

R. Hevey ATTN: STEWS -TE-AN, A. De La Paz ATTN: Code 6816, R. Lambert ATTN: STEWS -TE-AN, J. Meason ATTN: STEWS -TE-AN, R. Dutchover Naval Surface...Weapons Center ATTN: STEWS -TE-AN, R. Hays ATTN: Code F30 ATTN: STEWS -TE-N, K. Cummings ATTN: Code F31 ATTN: STEWS -TE-N, T. Arellanes ATTN: Code F31, F...Warnock ATTN: STEWS -TE-NT, M. Squires ATTN: Code F31, K. Caudle ATTN: Code WA-52, R. Smith USA Missile Command ATTN: F31, J. Downs ATTN: AMSMI-SF, G

Evaluation of propellent tank insulation concepts for low-thrust chemical propulsion systems: Executive summary

NASA Technical Reports Server (NTRS)

Kramer, T.; Brogren, E.; Siegel, B.

1984-01-01

Cryogenic propellant tank insulations or liquid oxygen/liquid hydrogen low-thrust 2224N (500 lbf) propulsion systems (LTPS) were assessed. The insulation studied consisted of combinations of N2-purged foam and multilayer insulation (MLI) as well as He-purged MLI-only. Heat leak and payload performance predictions were made for three shuttle-launched LTPS designed for shuttle bay packaged payload densities of 56 kg cu/m (3.5 lbm/cu ft), 40 kg/cu m (2.5 lbm/cu ft) and 24 kg/cu m (1.5 lbm/cu ft). Foam/MLI insulations were found to increase LTPS payload delivery capability when compared with He-purged MLI-only. An additional benefit of foam/MLI was reduced operational complexity because orbiter cargo bay N2 purge gas could be used for MLI purging. Maximum payload mass benefit occurred when an enhanced convection, rather than natural convection, heat transfer was specified for the insulation purge enclosure. The enhanced convection environment allowed minimum insulation thickness to be used for the foam/MLI interface temperature selected to correspond to the moisture dew point in the N2 purge gas. Experimental verification of foam/MLI benefits was recommended. A conservative program cost estimate for testing a MLI-foam insulated tank was 2.1 million dollars. This cost could be reduced significantly without increasing program risk.

Antidepressant effects of Kai-Xin-San in fluoxetine-resistant depression rats.

PubMed

Dong, X Z; Wang, D X; Lu, Y P; Yuan, S; Liu, P; Hu, Y

2017-08-17

This study aimed to investigate the antidepressant effect and the mechanism of action of Kai-Xin-San (KXS) in fluoxetine-resistant depressive (FRD) rats. Two hundred male Wistar rats weighing 200±10 g were exposed to chronic and unpredictable mild stresses (CUMS) for 4 weeks and given fluoxetine treatment simultaneously. The rats that did not show significant improvement in behavioral indexes were chosen as the FRD model rats. These rats were randomly divided into four groups: FRD model control; oral fluoxetine and aspirin; oral KXS at a dose of 338 mg·kg-1·day-1; and oral KXS at a dose of 676 mg·kg-1·day-1. Rats continued to be exposed to CUMS and underwent treatment once a day for 3 weeks, then cytokine (COX-2, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-10, TGF-β, and TNF-α) levels in the hippocampus and serum, and organ coefficients were measured. Both doses of KXS improved the crossing and rearing frequencies, sucrose-preference index, and body weight in FRD rats. KXS at a dose of 338 mg·kg-1·day-1reduced COX-2, IL-2, IL-6, TNF-α levels, increased IL-10 level in the hippocampus, and reduced IL-2 and TNF-α levels in serum. KXS at a dose of 676 mg·kg-1·day-1reduced TNF-α level in the hippocampus, reduced IL-2 and TNF-α levels in serum, and increased IFN-γ and IL-10 levels in the hippocampus and serum. There were no significant differences in organ-coefficients of the spleen among and between groups. The results suggested that oral administration of KXS in FRD rats was effective in improving behavior disorders by influencing various inflammatory pathways.

Effects of a flavonoid-rich juice on inflammation, oxidative stress, and immunity in elite swimmers: a metabolomics-based approach.

PubMed

Knab, Amy M; Nieman, David C; Gillitt, Nicholas D; Shanely, R Andrew; Cialdella-Kam, Lynn; Henson, Dru A; Sha, Wei

2013-04-01

The effects of a flavonoid-rich fresh fruit and vegetable juice (JUICE) on chronic resting and postexercise inflammation, oxidative stress, immune function, and metabolic profiles (metabolomics analysis, gas-chromatography mass-spectrometry platform) in elite sprint and middle-distance swimmers were studied. In a randomized, crossover design with a 3-wk washout period, swimmers (n = 9) completed 10-d training with or without 16 fl oz of JUICE (230 mg flavonoids) ingested pre- and postworkout. Blood samples were taken presupplementation, post-10-d supplementation, and immediately postexercise, with data analyzed using a 2 × 3 repeated-measures ANOVA. Prestudy blood samples were also acquired from nonathletic controls (n = 7, age- and weight-matched) and revealed higher levels of oxidative stress in the swimmers, no differences in inflammation or immune function, and a distinct separation in global metabolic scores (R2Y [cum] = .971). Swim workouts consisted of high-intensity intervals (1:1, 1:2 swim-to-rest ratio) and induced little inflammation, oxidative stress, or immune changes. A distinct separation in global metabolic scores was found pre- to postexercise (R2Y [cum] = .976), with shifts detected in a small number of metabolites related to substrate utilization. No effect of 10-d JUICE was found on chronic resting levels or postexercise inflammation, oxidative stress, immune function, and shifts in metabolites. In conclusion, sprint and middle-distance swimmers had a slight chronic elevation in oxidative stress compared with nonathletic controls, experienced a low magnitude of postworkout perturbations in the biomarkers included in this study, and received no apparent benefit other than added nutrient intake from ingesting JUICE pre- and postworkout for 10 days.

Nicotine Significantly Improves Chronic Stress-Induced Impairments of Cognition and Synaptic Plasticity in Mice.

PubMed

Shang, Xueliang; Shang, Yingchun; Fu, Jingxuan; Zhang, Tao

2017-08-01

The aim of this study was to examine if nicotine was able to improve cognition deficits in a mouse model of chronic mild stress. Twenty-four male C57BL/6 mice were divided into three groups: control, stress, and stress with nicotine treatment. The animal model was established by combining chronic unpredictable mild stress (CUMS) and isolated feeding. Mice were exposed to CUMS continued for 28 days, while nicotine (0.2 mg/kg) was also administrated for 28 days. Weight and sucrose consumption were measured during model establishing period. The anxiety and behavioral despair were analyzed using the forced swim test (FST) and open-field test (OFT). Spatial cognition was evaluated using Morris water maze (MWM) test. Following behavioral assessment, both long-term potentiation (LTP) and depotentiation (DEP) were recorded in the hippocampal dentate gyrus (DG) region. Both synaptic and Notch1 proteins were measured by Western. Nicotine increased stressed mouse's sucrose consumption. The MWM test showed that spatial learning and reversal learning in stressed animals were remarkably affected relative to controls, whereas nicotine partially rescued cognitive functions. Additionally, nicotine considerably alleviated the level of anxiety and the degree of behavioral despair in stressed mice. It effectively mitigated the depression-induced impairment of hippocampal synaptic plasticity, in which both the LTP and DEP were significantly inhibited in stressed mice. Moreover, nicotine enhanced the expression of synaptic and Notch1 proteins in stressed animals. The results suggest that nicotine ameliorates the depression-like symptoms and improves the hippocampal synaptic plasticity closely associated with activating transmembrane ion channel receptors and Notch signaling components. Graphical Abstract ᅟ.

Oxygen isotope geochemistry of the amphiboles: isotope effects of cation substitutions in minerals

NASA Astrophysics Data System (ADS)

Kohn, Matthew J.; Valley, John W.

1998-06-01

The occurrence of coexisting amphiboles in rocks and the likelihood of concurrent isotope closure allows equilibrium oxygen isotope fractionations among the amphiboles to be recovered from natural samples. Oxygen isotope analyses of mineral separates using laser fluorination show that coexisting amphiboles increasingly partition 18O in the order: hornblende ≪ gedrite < cummingtonite ≤ anthophyllite. The observed fractionations at ˜575°C are: Δ(Ged-Hbl) = 0.8‰, Δ(Cum-Hbl) = 0.9, Δ(Cum-Ged) = 0.2, Δ(Ath-Ged) = 0.3, and Δ(Ath-Hbl) > 0.9. Previously published data for hornblende, actinolite, glaucophane, and garnet show that Δ(Act-Hbl) ˜ 0.2, Δ(Gln-Grt) ≫ 1, and Δ(Hbl-Grt) ˜ 0. Thus, glaucophane strongly partitions 18O relative to the calcic amphiboles. The fractionation between two amphiboles of arbitrary composition can be predicted from the known fractionations for mica endmembers, pyroxene endmembers, and exchange components such as CaAl(NaSi) -1, NaAl(CaMg) -1, CaMg -1, MgFe -1, FeMn -1, KNa -1, KAl( Si) -1, and Fe 3+Al -1. Applications of the exchange component method reproduce measured amphibole fractionations to within ±0.1 to ±0.2‰, whereas other predictive methods cause misfit for typical metamorphic hornblende of ≥0.5‰ at 575°C. Although the isotope effects of cation exchanges may be small at high-T, they magnify dramatically for minerals formed in surficial, diagenetic, and low-T metamorphic environments. Different composition clays are predicted to have equilibrium δ 18O differences of 2-9‰. If the isotope fractionation can be determined for one mineral endmember, then calibrated exchanges allow accurate prediction of the isotope fractionations for intermediate compositions of most ortho-, ring-, chain-, and sheet-silicates.

Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression

PubMed Central

Rana, Digvijay G.; Galani, Varsha J.

2014-01-01

Background: The effects of antidepressant treatments have traditionally been discussed primarily in terms of effects on noradrenergic and serotonergic systems. Multiple lines of investigation have also explored the role of dopaminergic systems in mental depression. Seed of Mucuna pruriens Linn. (DC) (Leguminoseae) is well-known with dopaminergic action and has several therapeutic applications in folk medicine in curing or managing a wide range of diseases including Parkinsonism. Aim: To elucidate the anti-depressent profile and possible dopaminergic modulating action of M. pruriens seeds in various experimental models of depression. Materials and Methods: In the present study, antidepressant effect of the hydroalcoholic extract of the M. pruriens seeds (MPE) (100 and 200 mg/kg, p.o.) was investigated in the Forced Swimming Test (FST), Tail Suspension Test (TST), and Chronic Unpredictable Mild Stress (CUMS) test in mice. Further, dopaminergic interaction of same doses of MPE in the FST and TST were checked by the administration of a haloperidol (0.1 mg/kg, i.p.) and bromocriptine (2 mg/kg, i.p.) on the 7th day of MPE treatment. Effect of MPE on locomotor activity was also checked using actophotometer. Results: MPE produced a significant reduction of the immobility time in the FST and TST. Further, antidepressant action of MPE was significantly inhibited by haloperidol and potentiated by bromocriptine in the FST and TST. 21 days of MPE treatment produced protection in CUMS as indicated by a significant increase of sucrose intake of stressed mice. Locomotor activities of mice were not significantly changed after 1 h and 7th day of the MPE treatment. Conclusion: The results of this study indicate that hydroalcoholic extract of MPE have antidepressant action, which may be mediated by an interaction with the dopaminergic system. PMID:25364207

Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression.

PubMed

Rana, Digvijay G; Galani, Varsha J

2014-01-01

The effects of antidepressant treatments have traditionally been discussed primarily in terms of effects on noradrenergic and serotonergic systems. Multiple lines of investigation have also explored the role of dopaminergic systems in mental depression. Seed of Mucuna pruriens Linn. (DC) (Leguminoseae) is well-known with dopaminergic action and has several therapeutic applications in folk medicine in curing or managing a wide range of diseases including Parkinsonism. To elucidate the anti-depressent profile and possible dopaminergic modulating action of M. pruriens seeds in various experimental models of depression. In the present study, antidepressant effect of the hydroalcoholic extract of the M. pruriens seeds (MPE) (100 and 200 mg/kg, p.o.) was investigated in the Forced Swimming Test (FST), Tail Suspension Test (TST), and Chronic Unpredictable Mild Stress (CUMS) test in mice. Further, dopaminergic interaction of same doses of MPE in the FST and TST were checked by the administration of a haloperidol (0.1 mg/kg, i.p.) and bromocriptine (2 mg/kg, i.p.) on the 7(th) day of MPE treatment. Effect of MPE on locomotor activity was also checked using actophotometer. MPE produced a significant reduction of the immobility time in the FST and TST. Further, antidepressant action of MPE was significantly inhibited by haloperidol and potentiated by bromocriptine in the FST and TST. 21 days of MPE treatment produced protection in CUMS as indicated by a significant increase of sucrose intake of stressed mice. Locomotor activities of mice were not significantly changed after 1 h and 7(th) day of the MPE treatment. The results of this study indicate that hydroalcoholic extract of MPE have antidepressant action, which may be mediated by an interaction with the dopaminergic system.

Coherent Rabi Dynamics of a Superradiant Spin Ensemble in a Microwave Cavity

NASA Astrophysics Data System (ADS)

Rose, B. C.; Tyryshkin, A. M.; Riemann, H.; Abrosimov, N. V.; Becker, P.; Pohl, H.-J.; Thewalt, M. L. W.; Itoh, K. M.; Lyon, S. A.

2017-07-01

We achieve the strong-coupling regime between an ensemble of phosphorus donor spins in a highly enriched 28Si crystal and a 3D dielectric resonator. Spins are polarized beyond Boltzmann equilibrium using spin-selective optical excitation of the no-phonon bound exciton transition resulting in N =3.6 ×1 013 unpaired spins in the ensemble. We observe a normal mode splitting of the spin-ensemble-cavity polariton resonances of 2 g √{N }=580 kHz (where each spin is coupled with strength g ) in a cavity with a quality factor of 75 000 (γ ≪κ ≈60 kHz , where γ and κ are the spin dephasing and cavity loss rates, respectively). The spin ensemble has a long dephasing time (T2*=9 μ s ) providing a wide window for viewing the dynamics of the coupled spin-ensemble-cavity system. The free-induction decay shows up to a dozen collapses and revivals revealing a coherent exchange of excitations between the superradiant state of the spin ensemble and the cavity at the rate g √{N }. The ensemble is found to evolve as a single large pseudospin according to the Tavis-Cummings model due to minimal inhomogeneous broadening and uniform spin-cavity coupling. We demonstrate independent control of the total spin and the initial Z projection of the psuedospin using optical excitation and microwave manipulation, respectively. We vary the microwave excitation power to rotate the pseudospin on the Bloch sphere and observe a long delay in the onset of the superradiant emission as the pseudospin approaches full inversion. This delay is accompanied by an abrupt π -phase shift in the peusdospin microwave emission. The scaling of this delay with the initial angle and the sudden phase shift are explained by the Tavis-Cummings model.

Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway.

PubMed

Gawali, Nitin B; Bulani, Vipin D; Gursahani, Malvika S; Deshpande, Padmini S; Kothavade, Pankaj S; Juvekar, Archana R

2017-05-15

Agmatine, a neurotransmitter/neuromodulator, has shown to exert numerous effects on the CNS. Chronic stress is a risk factor for development of depression, anxiety and deterioration of cognitive performance. Compelling evidences indicate an involvement of nitric oxide (NO) pathway in these disorders. Hence, investigation of the beneficial effects of agmatine on chronic unpredictable mild stress (CUMS)-induced depression, anxiety and cognitive performance with the involvement of nitrergic pathway was undertaken. Mice were subjected to a battery of stressors for 28days. Agmatine (20 and 40mg/kg, i.p.) alone and in combination with NO modulators like L-NAME (15mg/kg, i.p.) and l-arginine (400mg/kg i.p.) were administered daily. The results showed that 4-weeks CUMS produces significant depression and anxiety-like behaviour. Stressed mice have also shown a significant high serum corticosterone (CORT) and low BDNF level. Chronic treatment with agmatine produced significant antidepressant-like behaviour in forced swim test (FST) and sucrose preference test, whereas, anxiolytic-like behaviour in elevated plus maze (EPM) and open field test (OFT) with improved cognitive impairment in Morris water maze (MWM). Furthermore, agmatine administration reduced the levels of acetylcholinesterase and oxidative stress markers. In addition, agmatine treatment significantly increased the BDNF level and inhibited serum CORT level in stressed mice. Treatment with L-NAME (15mg/kg) potentiated the effect of agmatine whereas l-arginine abolished the anxiolytic, antidepressant and neuroprotective effects of agmatine. Agmatine showed marked effect on depression and anxiety-like behaviour in mice through nitrergic pathway, which may be related to modulation of oxidative-nitrergic stress, CORT and BDNF levels. Copyright © 2017 Elsevier B.V. All rights reserved.

Role of hypothalamic cannabinoid receptors in post-stroke depression in rats.

PubMed

Wang, Shanshan; Sun, Hong; Liu, Sainan; Wang, Ting; Guan, Jinqun; Jia, Jianjun

2016-03-01

One of the most common psychological consequences of stroke is post-stroke depression (PSD). While more than 30 percent of stroke patients eventually develop PSD, the neurobiological mechanisms underlying such a phenomenon have not been well investigated. Given the critical involvement of hypothalamic-pituitary-adrenal axis and endocannabinoid system in response to stressful stimuli, we evaluated the hypothesis that cannabinoid receptors in the hypothalamus are critical for modulation of post-stroke depression-like behaviors in rats. To this end, rats were treated with middle cerebral artery occlusion (MCAO) followed by chronic unpredictable mild stress (CUMS) treatment procedure. We then assessed the expression of CB1 and CB2 receptors in the hypothalamus, and evaluated the effects of pharmacological stimulations of CB1 or CB2 receptors on the expression and development of depression-like behaviors in PSD rats. We found that PSD rats exhibited decreased the expression of CB1 receptor, but not CB2 receptor, in the ventral medial hypothalamus (VMH). Such an effect was not observed in the dorsally adjacent brain regions. Furthermore, intra-VMH injections of CB2 receptor agonist, but not CB1 receptor agonist, attenuated the expression of depression-like behaviors in PSD rats. Finally, repeated intraperitoneal injections of CB1 or CB2 receptor agonists during CUMS treatment inhibited the development of depression-like behaviors in PSD rats. Taken together, these results suggest that decreased CB1 receptor expression is likely associated with the development of post-stroke depression, and CB2 receptor may be a potential therapeutic target for the treatment post-stroke depressive disorders. Copyright © 2016 Elsevier Inc. All rights reserved.

Alarin-induced antidepressant-like effects and their relationship with hypothalamus-pituitary-adrenal axis activity and brain derived neurotrophic factor levels in mice.

PubMed

Wang, Ming; Chen, Qian; Li, Mei; Zhou, Wei; Ma, Tengfei; Wang, Yun; Gu, Shuling

2014-06-01

Alarin is a newly identified member of the galanin family of peptides. Galanin has been shown to exert regulatory effects on depression. Similar to galanin in distribution, alarin is also expressed in the medial amygdala and hypothalamus, i.e., regions interrelated with depression. However, it remains a puzzle whether alarin is involved in depression. Accordingly, we established the depression-like mouse model using behavioral tests to ascertain the possible involvement of alarin, with fluoxetine as a positive control. With the positive antidepressant-like effects of alarin, we further examined its relationship to HPA axis activity and brain-derived neurotrophic factor (BDNF) levels in different brain areas in a chronic unpredictable mild stress (CUMS) paradigm. In the acute studies, alarin produced a dose-related reduction in the immobility duration in tail suspension test (TST) in mice. In the open-field test, intracerebroventricular (i.c.v.) injection of alarin (1.0 nmol) did not impair locomotion or motor coordination in the treated mice. In the CUMS paradigm, alarin administration (1.0 nmol, i.c.v.) significantly improved murine behaviors (FST and locomotor activity), which was associated with a decrease in corticotropin-releasing hormone (CRH) mRNA levels in the hypothalamus, as well as a decline in serum levels of CRH, adrenocorticotropic hormone (ACTH) and corticosterone (CORT), all of which are key hormones of the HPA axis. Furthermore, alarin upregulated BDNF mRNA levels in the prefrontal cortex and hippocampus. These findings suggest that alarin may potentiate the development of new antidepressants, which would be further secured with the identification of its receptor(s). Copyright © 2014 Elsevier Inc. All rights reserved.

Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress.

PubMed

Xing, Hang; Zhang, Kuo; Zhang, Ruowen; Shi, Huiyan; Bi, Kaishun; Chen, Xiaohui

2015-12-01

Water extract of the fixed combination of Gardenia jasminoides Ellis fruit, Citrus aurantium L. fruit and Magnolia officinalis Rehd. et Wils. bark, traditional name - Zhi-Zi-Hou-Po (ZZHPD) is used for treatment of depressive-like symptoms in traditional Chinese medicine for centuries. The present study aimed to explore antidepressant-like effects and potential mechanisms of ZZHPD in a rat model of chronic unpredictable mild stress (CUMS). Antidepressant-like effects of ZZHPD were investigated through behavioral tests, and potential mechanism was assessed by neuroendocrine system, neurotrophin and hippocampal neurogenesis. Antidepressant-like effects of ZZHPD (3.66, 7.32 and 14.64 g/kg/day) were estimated through coat state test, sucrose preference test, forced swimming test and open-field test. Effects of ZZHPD on hypothalamic-pituitary-adrenal (HPA) axis were evaluated by hormones measurement and dexamethasone suppression test. In addition, the expression of brain-derived neurotrophic factor (BDNF) in hippocampus was measured, as well as hippocampal neurogenesis was investigated by doublecortin (DCX) and 5-bromo-2-deoxyuridine/neuronal nuclei (BrdU/NeuN). The results demonstrated that ZZHPD significantly reversed the depressive-like behaviors, normalized the levels of adrenocorticotropic hormone (ACTH) and corticosterone (CORT), restored the negative feedback loop of HPA axis and improved the levels of BDNF, DCX and BrdU/NeuN compared with those in CUMS-induced rats. The above results revealed that ZZHPD exerted antidepressant-like effects possibly by normalizing HPA axis function, increasing expression of BDNF in hippocampus and promoting hippocampal neurogenesis. Copyright © 2015 Elsevier GmbH. All rights reserved.

Noise Scaling and Community Noise Metrics for the Hybrid Wing Body Aircraft

NASA Technical Reports Server (NTRS)

Burley, Casey L.; Brooks, Thomas F.; Hutcheson, Florence V.; Doty, Michael J.; Lopes, Leonard V.; Nickol, Craig L.; Vicroy, Dan D.; Pope, D. Stuart

2014-01-01

An aircraft system noise assessment was performed for the hybrid wing body aircraft concept, known as the N2A-EXTE. This assessment is a result of an effort by NASA to explore a realistic HWB design that has the potential to substantially reduce noise and fuel burn. Under contract to NASA, Boeing designed the aircraft using practical aircraft design princip0les with incorporation of noise technologies projected to be available in the 2020 timeframe. NASA tested 5.8% scale-mode of the design in the NASA Langley 14- by 22-Foot Subsonic Tunnel to provide source noise directivity and installation effects for aircraft engine and airframe configurations. Analysis permitted direct scaling of the model-scale jet, airframe, and engine shielding effect measurements to full-scale. Use of these in combination with ANOPP predictions enabled computations of the cumulative (CUM) noise margins relative to FAA Stage 4 limits. The CUM margins were computed for a baseline N2A-EXTE configuration and for configurations with added noise reduction strategies. The strategies include reduced approach speed, over-the-rotor line and soft-vane fan technologies, vertical tail placement and orientation, and modified landing gear designs with fairings. Combining the inherent HWB engine shielding by the airframe with added noise technologies, the cumulative noise was assessed at 38.7 dB below FAA Stage 4 certification level, just 3.3 dB short of the NASA N+2 goal of 42 dB. This new result shows that the NASA N+2 goal is approachable and that significant reduction in overall aircraft noise is possible through configurations with noise reduction technologies and operational changes.

Operational and troubleshooting experiences in the SST-1 cryogenic system

NASA Astrophysics Data System (ADS)

Mahesuria, G.; Panchal, P.; Panchal, R.; Patel, R.; Sonara, D.; Gupta, N. C.; Srikanth, G. L. N.; Christian, D.; Garg, A.; Bairagi, N.; Patel, K.; Shah, P.; Nimavat, H.; Sharma, R.; Patel, J. C.; Tank, J.; Tanna, V. L.; Pradhan, S.

2014-01-01

Recently, the cooldown and current charging campaign have been carried out towards the demonstration of the first successful plasma discharge in the steady state superconducting Tokomak (SST-1). The SST-1 machine consists of cable-in-conduit wound superconducting toroidal as well as poloidal coils, cooled using 1.3 kW at 4.5 K helium refrigerator -cum- liquefier (HRL) system. The cryo system provides the two-phase helium at 0.13 MPa at 4.5 K as well as forced-flow pressurized helium at 0.4 MPa and in addition to 7 g-s-1 liquefaction capacity required for the current leads and other cold mass at 4.5 K. The entire integrated cold masses having different thermo hydraulic resistances cooled with the SST-1 HRL in optimised process parameters. In order to maintain different levels of temperatures and to facilitate smooth and reliable cooldown, warm-up, normal operations as well as to handle abnormal events such as, quench or utilities failures etc., exergy efficient process are adopted for the helium refrigerator-cum-liquefier (HRL) with an installed equivalent capacity of 1.3 kW at 4.5 K. Using the HRL, the cold mass of about 40 tons is being routinely cooled down from ambient temperature to 4.5 K with an average cooldown rate of 0.75 - 1 K-h-1. Long-term cryogenic stable conditions were obtained within 15 days in the superconducting coils and their connecting feeders. Afterwards, all of the cold mass is warmed-up in a controlled manner to ambient temperature. In this paper, we report the recent operational results of the cryogenic system during the first plasma discharge in SST-1 as well as the troubleshooting experiences of the cryogenic plant related hardware.

The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice.

PubMed

Hong, Y H; Huang, C J; Wang, S C; Lin, B F

2009-03-01

Previous study showed that soy isoflavone supplement alleviates disease severity in autoimmune-prone mice. As the ethyl acetate extract of alfalfa sprout (AS) has selective oestrogenic and anti-inflammatory activity, this study evaluated the effects of alfalfa sprout ethyl acetate extract (ASEA) on disease severity of systemic lupus erythematosus, using autoimmune-prone female MRL-lpr/lpr mice. In Experiment 1, five groups of 12-week-old female mice were per oral treated with vehicle (control), lyophilized AS (550 mg wt/kg BW), ASEA (ASEA, 25 mg/kg BW), coumestrol (CUM, 0.075 mg/kg BW) and tamoxifen (TAM, 0.375 mg/kg BW) as the positive control. The onset of proteinuria was delayed, and the life span was significantly longer in the ASEA and TAM groups but neither in the AS nor in the CUM groups, compared to the control. To examine the changes in the immunological parameters related to disease process, three more groups of MRL-lpr/lpr female mice (control, ASEA and TAM) were fed in a similar manner for 6 weeks in the Experiment 2. Flow cytometric analysis of splenocytes showed a significantly lower percentage of activated T cells in the ASEA and TAM groups. The ex-vivo interferon-gamma and interleukin (IL)-4 production from splenocytes and tumour necrosis factor-alpha and IL-1beta production from peritoneal exudate cells were also significantly lower in the ASEA group compared with the control. The ASEA group also had less severe glomerulonephritis. Thus, ASEA attenuated cytokine and inflammatory responses of self-reactive lymphocytes, decreased the disease severity, increased survival and life span of the autoimmune-prone MRL-lpr/lpr mice, suggesting a potential of ASEA in the treatment of autoimmune diseases.

Interrenal dysfunction in fish from contaminated sites: In vivo and in vitro studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hontela, A.

1995-12-31

An endocrine impairment characterized by a reduced capacity to elevate plasma cortisol levels in response to an acute standardized capture stress, has been previously diagnosed in yellow perch, Perca flavescens, and in northern pike, Esox lucius, from sites contaminated by mixtures of pollutants (heavy metals, PAHs and PCBs) or by BKME. The most recent studies were designed to (1) field validate this dysfunction usable as a marker of reduced physiological competence in fish; (2) demonstrate the impairment of the interrenal tissue in fish from sites located in a mining region in Abitibi; and (3) elucidate the physiological mechanisms underlying themore » impairment of the interrenal tissue in fish chronically exposed to xenobiotics. The responsiveness of the interrenal tissue to a standardized dose of ACTH1-39 was assessed in vivo in yellow perch from contaminated and reference sites maintained in experimental enclosures, as well as in vitro using complete growth medium in a perifusion system and in microplates. The results showed that the functional impairment of the internal tissue in fish exposed to xenobiotics is an exposure related phenomenon modulated by season. The functional tests with the interrenal tissue revealed that the responsiveness to ACTH is significantly reduced and that the synthesis of cortisol is disrupted, in fish from contaminated sites. Use of the functional ACTH-tests with the interrenal tissue of fish in environmental monitoring will be discussed.« less

Polariton condensation with saturable molecules dressed by vibrational modes

DOE PAGES

Cwik, Justyna A.; Reja, Sahinur; Littlewood, Peter B.; ...

2014-02-01

Here, polaritons, mixed light-matter quasiparticles, undergo a transition to a condensed, macroscopically coherent state at low temperatures or high densities. Recent experiments show that coupling light to organic molecules inside a microcavity allows condensation at room temperature. The molecules act as saturable absorbers with transitions dressed by molecular vibrational modes. Motivated by this, we calculate the phase diagram and spectrum of a modified Tavis-Cummings model, describing vibrationally dressed two-level systems, coupled to a cavity mode. Coupling to vibrational modes can induce re-entrance, i.e. a normal-condensed-normal sequence with decreasing temperature and can drive the transition first-order.

Effect of nanosecond UV laser irradiation on luminescence and absorption in silver- and copper-containing phosphate glasses

NASA Astrophysics Data System (ADS)

Murashov, A. A.; Sidorov, A. I.; Stoliarchuk, M. V.

2018-03-01

Experimental evidence is presented that nanosecond UV laser irradiation of silver- and copper-containing barium phosphate glasses leads to luminescence quenching in the visible range. Subsequent heat treatment induces an absorption in the range 350–500 nm. These effects are due to the ionisation and fragmentation of subnanometre molecular clusters by laser radiation and subsequent (heat treatment-induced) formation of nanoparticles possessing plasmon resonance. Our numerical modelling results demonstrate the feasibility of producing stable AgnCum hybrid molecular clusters in glass. Local modification of the optical properties of glass by laser light can be used for optical information recording.

Lester Machta (1919-2001)

NASA Astrophysics Data System (ADS)

Seidel, Dian; Angell, Jim

Lester Machta, the former director of the NOAA Air Resources Laboratory and an AGU Fellow, died August 31, 2001, of leukemia. For more than half a century, he led pioneering research programs in air quality that addressed some of the key environmental issues of our times, and he did so with a rare devotion to both science and public service. He had been an AGU member since 1950 (Atmospheric Sciences).A native New Yorker, he obtained a B.A. in mathematics (cum laude) from Brooklyn College and, after the war, he completed an M.S. in meteorology at NYU and an ScD. in meteorology from the Massachusetts Institute of Technology

Optical observations of Swift J1822.3-1606 with the 10.4m Gran Telescopio Canarias

NASA Astrophysics Data System (ADS)

Rea, N.; Mignani, R. P.; Israel, G. L.; Esposi, P.

2011-07-01

We observed the field of the new Soft Gamma-ray Repeater (SGR), Swift J1822.3-1606 (Cummings et al., Atel #3488) with the 10.4m Gran Telescopio Canarias (GranTeCan). Images have been taken with the OSIRIS camera, a two-chip CCD with a nominal 7.8'x7.8' arcmin field of view and a pixel size of 0.125". Observations have been taken in the z-Sloan-band on 2011 July 21st (unfortunately in bright lunar time, with a large sky background and a seeing ranging from 1-2.5") with exposure times of 54-108s.

RXTE Detection of the Spin Period of Swift J1822.3-1606

NASA Astrophysics Data System (ADS)

Gogus, Ersin; Kouveliotou, Chryssa; Strohmayer, Tod

2011-07-01

RXTE/PCA observed the new source, Swift J1822.3-1606 (Cummings et al. GCN Circ. 12159) on 2011 July 16, for 6.7 ks. We performed a timing analysis on the barycentered data and detected a coherent pulsation at 0.1185149(2) Hz corresponding to 8.4377585 s. Pulsations are clearly visible in the PCA light curve. The peak-to-peak pulsed amplitude in the 2-10 keV band is 0.41. This pulsed fraction is highly unlikely from an SGR source, and very reminiscent of the outburst onset of Swift J1626.6-5156 (Palmer et al.

SGR 1822-1606 (Swift 1822.3-1606): Spin-down rate and inferred dipole field strength

NASA Astrophysics Data System (ADS)

Gogus, Ersin; Strohmayer, Tod; Kouveliotou, Chryssa

2011-07-01

We have been monitoring the new source Swift 1822.3-1606 (Cummings et al. GCN 12159) with RXTE. We acquired a total exposure of 20.6 ks in 5 pointings, spanning a time baseline of 5 days. We clearly detect the 8.44 s pulsations reported earlier (Pagani et al. ATel #3489, Gogus et al ATel #3491, Rea et al Atel #3501). We employed an epoch folding technique to determine the spin ephemeris. Our preliminary analysis reveal the spin period, P = 8.4377158(9) s and the spin-down rate, Pdot = 2.2(5) x 10-11 s/s (Epoch: 55758.5 MJD).

Single atom emission in an optical resonator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childs, J.J.; An, K.; Dasari, R.R.

A single atom coupled to a single mode of a radiation field is a fundamental system for studying the interaction of radiation with matter. The study of such systems has come to be called cavity quantum electrodynamics (QED). Atoms coupled to a single mode of a resonator have been studied experimentally and theoretically in several interesting regimes since this basic system was first considered theoretically by Janes and Cummings. The objective of the present chapter is to provide a theoretical framework and present a unifying picture of the various phenomena which can occur in such a system. 35 refs., 11more » figs.« less

After p Values: The New Statistics for Undergraduate Neuroscience Education.

PubMed

Calin-Jageman, Robert J

2017-01-01

Statistical inference is a methodological cornerstone for neuroscience education. For many years this has meant inculcating neuroscience majors into null hypothesis significance testing with p values. There is increasing concern, however, about the pervasive misuse of p values. It is time to start planning statistics curricula for neuroscience majors that replaces or de-emphasizes p values. One promising alternative approach is what Cumming has dubbed the "New Statistics", an approach that emphasizes effect sizes, confidence intervals, meta-analysis, and open science. I give an example of the New Statistics in action and describe some of the key benefits of adopting this approach in neuroscience education.

Protracted tectono-metamorphic history of the SE Superior Province : contribution of 40Ar/39Ar thermochronology in the Abitibi-Opatica contact zone, Québec, Canada

NASA Astrophysics Data System (ADS)

Daoudene, Yannick; Tremblay, Alain; Ruffet, Gilles; Leclerc, François; Goutier, Jean

2015-04-01

Archean orogens mainly consist of greenstone belts juxtaposing deeper crustal domains of TTG-type plutonic rocks. The greenstone belts show regional folds, penetrative steeply-dipping fabrics, and localised shear zones, whereas the plutonic belts predominantly display dome structures. Concurrently, rocks in Archean orogens undergone MT/HT-LP/MP metamorphic conditions that vary, from upper to lower crustal domains, between greenschist- and granulite-facies, respectively. These structural and metamorphic variations are well-documented, but modes of deformation related to such orogens is still debated. Some studies suggest that the Archean tectonic processes were comparable to present-day plate tectonics and the Archean greenstone belts were interpreted as tectonic collages commonly documented in Phanerozoic subduction/collision zones. Alternative models propose that the Archean tectonics were different from those predicted by the plate tectonics paradigm, mainly due to the existence of a hotter mantle and a mechanically weak crust. In such models, the burying and exhumation of crustal rocks are attributed to the vertical transfer of material, resulting in the development of pop-down and domes structures. As a contribution of the study of mechanisms that might have operated during the Archean, we present a structural and metamorphic study of the contact zone between the Abitibi subprovince (ASP), which contains greenstone belts, and the Opatica subprovince (OSP), which is dominated by plutonic rocks, of the Superior Province. The 40Ar/39Ar dating of amphiboles and micas is used to constrain the age and duration of regional metamorphism and associated deformations. On the basis of seismic profiling, showing a north-dipping lithospheric-scale reflector, the ASP-OSP contact has been interpreted as the surficial trace of an Archean subduction zone. However, our structural analysis suggest that the ASP overlies the OSP and that the ASP-OSP contact does not show evidences of an important sub-vertical shearing deformation as expected if it was a major upper plate-lower plate boundary. Furthermore, the contact does not present significant metamorphic break between the two domains, but a progressive increasing of metamorphism toward the OSP, from greenschist- to amphibolite-facies conditions. Based on these structural and metamorphic characteristics, we suggest that the OSP exposes the deepest rocks at outcrop of an ASP-OSP crust in the study area. Regionally, the 40Ar/39Ar ages acquired during this study indicate that the ASP-OSP contact records a protracted metamorphic history that started around 2685 Ma. The structural and isotopic age data suggest that, from ~2685 Ma to ~2632 Ma, the deepest level of the ASP and the underlying OSP reached amphibolite-facies metamorphic conditions and that regional deformation was accommodated by an overall horizontal shortening and sub-vertical transfers of crustal material. Subsequently, the cooling of these crustal rocks was accompanied by strain localisation, which led to the development of oblique strike-slip shear zones from ~2600 Ma, when the lateral flowing of crustal material became predominant. Our 40Ar/39Ar data compared with metamorphic ages documented in adjacent areas of the Superior Province suggests that the peak and duration of regional metamorphism might have been coeval over a large region. This rather favours a mode of pervasive deformation as expected in vertical tectonics.

Integration of borehole and seismic data to unravel complex stratigraphy: Case studies from the Mannville Group, Western Canada

NASA Astrophysics Data System (ADS)

Sarzalejo Silva, Sabrina Ester

Understanding the stratigraphic architecture of geologically complex reservoirs, such as the heavy oil deposits of Western Canada, is essential to achieve an efficient hydrocarbon recovery. Borehole and 3-D seismic data were integrated to define the stratigraphic architecture and generate 3-dimensional geological models of the Mannville Group in Saskatchewan. The Mannville is a stratigraphically complex unit formed of fluvial to marine deposits. Two areas in west-central and southern Saskatchewan were examined in this study. In west-central Saskatchewan, the area corresponds to a stratigraphically controlled heavy oil reservoir with production from the undifferentiated Dina-Cummings Members of the Lower Cretaceous Mannville Group. The southern area, although non-prospective for hydrocarbons, shares many similarities with time-equivalent strata in areas of heavy oil production. Seismic sequence stratigraphic principles together with log signatures permitted the subdivision of the Mannville into different packages. An initial geological model was generated integrating seismic and well-log data Multiattribute analysis and neural networks were used to generate a pseudo-lithology or gamma-ray volume. The incorporation of borehole core data to the model and the subsequent integration with the lithological prediction were crucial to capture the distribution of reservoir and non-reservoir deposits in the study area. The ability to visualize the 3-D seismic data in a variety of ways, including arbitrary lines and stratal or horizon slicing techniques helped the definition of stratigraphic features such as channels and scroll bars that affect fluid flow in hydrocarbon producing areas. Small-scale heterogeneities in the reservoir were not resolved due to the resolution of the seismic data. Although not undertaken in this study, the resulting stratigraphic framework could be used to help construct a static reservoir model. Because of the small size of the 3-D seismic surveys, horizontal slices through the data volume generally imaged only small portions of the paleogeomorphologic features thought to be present in this area. As such, it was only through the integration of datasets that the geological models were established.

Socio-Environmental Resilience and Complex Urban Systems Modeling

NASA Astrophysics Data System (ADS)

Deal, Brian; Petri, Aaron; Pan, Haozhi; Goldenberg, Romain; Kalantari, Zahra; Cvetkovic, Vladimir

2017-04-01

The increasing pressure of climate change has inspired two normative agendas; socio-technical transitions and socio-ecological resilience, both sharing a complex-systems epistemology (Gillard et al. 2016). Socio-technical solutions include a continuous, massive data gathering exercise now underway in urban places under the guise of developing a 'smart'(er) city. This has led to the creation of data-rich environments where large data sets have become central to monitoring and forming a response to anomalies. Some have argued that these kinds of data sets can help in planning for resilient cities (Norberg and Cumming 2008; Batty 2013). In this paper, we focus on a more nuanced, ecologically based, socio-environmental perspective of resilience planning that is often given less consideration. Here, we broadly discuss (and model) the tightly linked, mutually influenced, social and biophysical subsystems that are critical for understanding urban resilience. We argue for the need to incorporate these sub system linkages into the resilience planning lexicon through the integration of systems models and planning support systems. We make our case by first providing a context for urban resilience from a socio-ecological and planning perspective. We highlight the data needs for this type of resilient planning and compare it to currently collected data streams in various smart city efforts. This helps to define an approach for operationalizing socio-environmental resilience planning using robust systems models and planning support systems. For this, we draw from our experiences in coupling a spatio-temporal land use model (the Landuse Evolution and impact Assessment Model (LEAM)) with water quality and quantity models in Stockholm Sweden. We describe the coupling of these systems models using a robust Planning Support System (PSS) structural framework. We use the coupled model simulations and PSS to analyze the connection between urban land use transformation (social) and water (environmental) systems within the context of planning for a more resilient Stockholm. This work shows that complex urban systems models can help bridge the divide between socio-technological and socio-environmental systems knowledge and achieving resilient urban areas.

From Communication Skills to Skillful Communication: A Longitudinal Integrated Curriculum for Critical Care Medicine Fellows.

PubMed

Roze des Ordons, Amanda L; Doig, Christopher J; Couillard, Philippe; Lord, Jason

2017-04-01

Communication with patients and families in critical care medicine (CCM) can be complex and challenging. A longitudinal curricular model integrating multiple techniques within classroom and clinical milieus may facilitate skillful communication across diverse settings. In 2014-2015, the authors developed and implemented a curriculum for CCM fellows at the Cumming School of Medicine, University of Calgary, to promote the longitudinal development of skillful communication. A departmental needs assessment informed curriculum development. Five 4-hour classroom sessions were developed: basic communication principles, family meetings about goals and transitions of care, discussing patient safety incidents, addressing conflict, and offering organ donation. Teaching methods-including instructor-led presentations incorporating a consistent framework for approaching challenging conversations, simulation and clinical practice, and feedback from peers, trained facilitators, family members, and clinicians-supported integration of skills into the clinical setting and longitudinal development of skillful communication. Seven fellows participated during the first year of the curriculum. CCM fellows engaged enthusiastically in the program, commented that the framework provided was helpful, and highly valued the opportunity to practice challenging communication scenarios, learn from observing their peers, and receive immediate feedback. More detailed accounts of fellows', patients', and family members' experiences will be obtained to guide curricular development. The curriculum will be expanded to involve other members of the multidisciplinary intensive care unit team, and faculty education initiatives will be offered to enhance the quality of the feedback provided. The impact of the curriculum on initial skill development, retention, and progression will be assessed.

Does your model weigh the same as a Duck?

NASA Astrophysics Data System (ADS)

Jain, Ajay N.; Cleves, Ann E.

2012-01-01

Computer-aided drug design is a mature field by some measures, and it has produced notable successes that underpin the study of interactions between small molecules and living systems. However, unlike a truly mature field, fallacies of logic lie at the heart of the arguments in support of major lines of research on methodology and validation thereof. Two particularly pernicious ones are cum hoc ergo propter hoc (with this, therefore because of this) and confirmation bias (seeking evidence that is confirmatory of the hypothesis at hand). These fallacies will be discussed in the context of off-target predictive modeling, QSAR, molecular similarity computations, and docking. Examples will be shown that avoid these problems.

The Dirac-Moshinsky oscillator coupled to an external field and its connection to quantum optics

NASA Astrophysics Data System (ADS)

Torres, Juan Mauricio; Sadurní, Emerson; Seligman, Thomas H.

2010-12-01

The Dirac-Moshinsky oscillator is an elegant example of an exactly solvable quantum relativistic model that under certain circumstances can be mapped onto the Jaynes-Cummings model in quantum optics. In this work we show, how to do this in detail. Then we extend it by considering its coupling with an external (isospin) field and find the conditions that maintain solvability. We use this extended system to explore entanglement in relativistic systems and then identify its quantum optical analog: two different atoms interacting with an electromagnetic mode. We show different aspects of entanglement which gain relevance in this last system, which can be used to emulate the former.

On the control of spin-boson systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boscain, Ugo, E-mail: ugo.boscain@polytechnique.edu; Mason, Paolo, E-mail: Paolo.Mason@l2s.centralesupelec.fr; Panati, Gianluca, E-mail: panati@mat.uniroma1.it

2015-09-15

In this paper, we study the so-called spin-boson system, namely, a two-level system in interaction with a distinguished mode of a quantized bosonic field. We give a brief description of the controlled Rabi and Jaynes–Cummings models and we discuss their appearance in the mathematics and physics literature. We then study the controllability of the Rabi model when the control is an external field acting on the bosonic part. Applying geometric control techniques to the Galerkin approximation and using perturbation theory to guarantee non-resonance of the spectrum of the drift operator, we prove approximate controllability of the system, for almost everymore » value of the interaction parameter.« less

FAST TRACK COMMUNICATION: \\ {P}\\ {T}-symmetry, Cartan decompositions, Lie triple systems and Krein space-related Clifford algebras

NASA Astrophysics Data System (ADS)

Günther, Uwe; Kuzhel, Sergii

2010-10-01

Gauged \\ {P}\\ {T} quantum mechanics (PTQM) and corresponding Krein space setups are studied. For models with constant non-Abelian gauge potentials and extended parity inversions compact and noncompact Lie group components are analyzed via Cartan decompositions. A Lie-triple structure is found and an interpretation as \\ {P}\\ {T}-symmetrically generalized Jaynes-Cummings model is possible with close relation to recently studied cavity QED setups with transmon states in multilevel artificial atoms. For models with Abelian gauge potentials a hidden Clifford algebra structure is found and used to obtain the fundamental symmetry of Krein space-related J-self-adjoint extensions for PTQM setups with ultra-localized potentials.

The Compleat TRAIDsman.

DTIC Science & Technology

1969-09-01

uses a COMMON block of 663 cells . PLOTT works from a table of data, and assigns to each trace (up to 6 traces) a preset character. Once yoor data is...ALFA 000777 1 ~L P M A LP A U VU I 00) 󈧑 EL4 ’ I’LAC 4-43 FLIER slU.-r t;IINk fLIE" (5,LP.KONUA IlEI 335 50C k k LJ~C I~ N’.12 5 ExTEN, REVISION of...FLAG, PLACLD IN CumM"O. 753 C N3.0,0 AS RUN OAIE (IF BLANK* TAKEN FROM SYSTEM C DATE CELL ) ?SS C e1-63 13 EXECUTION TIME LIMIT IN MINUTES (IF ?b6 C

Development of balloon-borne reel-down and -up winch system

NASA Astrophysics Data System (ADS)

Matsuzaka, Y.; Yamagami, T.; Yamanaka, M. D.; Nishimura, J.

Balloon-borne winches, which can reel down and up scientific instruments repeatedly, have been developed since 1981 in order to observe stratospheric vertical microstuctures. The instrument is suspended by a kevler wire through a traverse-cum ropeguide, and its depth is accurately measured by counting numbers of spool rotations and ropeguide turns. Battery consumption is minimized by utilizing an efficient deccelerator and a hysteresis brake. In 1983 we have successfully performed to reel up and down a 12 kg payload through 1 km for three cycles at 24 km altitude. We are improving the capability of the winch, and have succeeded (May 1984) to reel down a 22 kg payload up to 3 km from a balloon.

Rocky Mountain Arsenal, North Boundary Containment/Treatment System, Operational Assessment Report FY85/FY86. Volume 3. Data Listings

DTIC Science & Technology

1987-06-01

Treatment System Water Quality Data I PART III: Monitoring Well Water Level Data I PART IV: Monitoring Well Water Quality Data I PART V: Dewatering...J. =r "c’ u, %-CUmC , ILn- cc 0 Q O-a CV...i c *- WcL MCQ . . C.. ....... o , a - 0 ro, WO- -- a sf’- -;MO IWM ý gMMU- r- %0 C-.o rW0" . A =a, 0 I...of water level data are given below: I WELL NO (WELL NUMBER) is made up of the sectf -n number (01-36) and the well sequence number (001-999) within

Nonlinear quantum Rabi model in trapped ions

NASA Astrophysics Data System (ADS)

Cheng, Xiao-Hang; Arrazola, Iñigo; Pedernales, Julen S.; Lamata, Lucas; Chen, Xi; Solano, Enrique

2018-02-01

We study the nonlinear dynamics of trapped-ion models far away from the Lamb-Dicke regime. This nonlinearity induces a blockade on the propagation of quantum information along the Hilbert space of the Jaynes-Cummings and quantum Rabi models. We propose to use this blockade as a resource for the dissipative generation of high-number Fock states. Also, we compare the linear and nonlinear cases of the quantum Rabi model in the ultrastrong and deep strong-coupling regimes. Moreover, we propose a scheme to simulate the nonlinear quantum Rabi model in all coupling regimes. This can be done via off-resonant nonlinear red- and blue-sideband interactions in a single trapped ion, yielding applications as a dynamical quantum filter.

Spring green-up date derived from GIMMS3g and SPOT-VGT NDVI of winter wheat cropland in the North China Plain

NASA Astrophysics Data System (ADS)

Liu, Zhengjia; Wu, Chaoyang; Liu, Yansui; Wang, Xiaoyue; Fang, Bin; Yuan, Wenping; Ge, Quansheng

2017-08-01

Satellite temporal resolution affects the fitting accuracy of vegetation growth curves. However, there are few studies that evaluate the impact of different satellite data (including temporal resolution and time series change) on spring green-up date (GUD) extraction. In this study, four GUD algorithms and two different temporal resolution satellite data (GIMMS3g during 1982-2013 and SPOT-VGT during 1999-2013) were used to investigate winter wheat GUD in the North China Plain. Four GUD algorithms included logistic-NDVI (normalized difference vegetation index), logistic-cumNDVI (cumulative NDVI), polynomial-NDVI and polynomial-cumNDVI algorithms. All algorithms and data were first regrouped into eight controlled cases. At site scale, we evaluated the performance of each case using correlation coefficient (r), bias and root mean square error (RMSE). We further compared spatial patterns and inter-annual trends of GUD inferred from different algorithms, and then analyzed the difference between GIMMS3g-based GUD and SPOT-VGT-based GUD. Our results showed that all satellite-based GUD were correlated with observations with r ranging from 0.32 to 0.57 (p < 0.01). SPOT-VGT-based GUD generally had better correlations with observed GUD than those of GIMMS3g. Spatially, SPOT-VGT-based GUD performed more reasonable spatial distributions. Inter-annual regional averaged satellite-based GUD presented overall advanced trends during 1982-2013 (0.3-2.0 days/decade) while delayed trends were observed during 1999-2013 (1.7-7.4 days/decade for GIMMS3g and 3.8-7.4 days/decade for SPOT-VGT). However, their significance levels were highly dependent on the data and algorithms used. Our findings suggest cautions on previous results of inter-annual variability of phenology from a single data/method.

Development and evaluation of low cost honey heating-cum-filtration system.

PubMed

Alam, Md Shafiq; Sharma, D K; Sehgal, V K; Arora, M; Bhatia, S

2014-11-01

A fully mechanized honey heating-cum-filtration system was designed, developed, fabricated and evaluated for its performance. The system comprised of two sections; the top heating section and the lower filtering section. The developed system was evaluated for its performance at different process conditions (25 kg and 50 kg capacity using processing condition: 50 °C heating temperature and 60 °C heating temperature with 20 and 40 min holding time, respectively) and it was found that the total time required for heating, holding and filtration of honey was 108 and 142 min for 25 kg and 50 kg capacity of machine, respectively, irrespective of the processing conditions. The optimum capacity of the system was found to be 50 kg and it involved an investment of Rs 40,000 for its fabrication. The honey filtered through the developed filtration system was compared with the honey filtered in a high cost honey processing plant and raw honey for its microbial and biochemical (reducing sugars (%), moisture, acidity and pH) quality attributes. It was observed that the process of filtering through the developed unit resulted in reduction of microbes. The microbiological quality of honey filtered through the developed filtration system was better than that of raw honey and commercially processed honey. The treatment conditions found best in context of microbiological counts were 60 °C temperature for 20 min. There was 1.97 fold reductions in the plate count and 2.14 reductions in the fungal count of honey processed through the developed filtration system as compared to the raw honey. No coliforms were found in the processed honey. Honey processed through developed unit witnessed less moisture content, acidity and more reducing sugars as compared to raw honey, whereas its quality was comparable to the commercially processed honey.

Let's inhibit our excitement: the relationships between Stroop, behavioral disinhibition, and the frontal lobes.

PubMed

Heflin, Lara H; Laluz, Victor; Jang, Jung; Ketelle, Robin; Miller, Bruce L; Kramer, Joel H

2011-09-01

The Stroop (Stroop, 1935) is a frequently used neuropsychological test, with poor performance typically interpreted as indicative of disinhibition and frontal lobe damage. This study tested those interpretations by examining relationships between Stroop performance, behavioral disinhibition, and frontal lobe atrophy. Participants were 112 patients with mild cognitive impairment or dementia, recruited through UCSF's Memory and Aging Center. Participants received comprehensive dementia evaluations including structural MRI, neuropsychological testing, and informant interviews. Freesurfer, a semiautomated parcellation program, was used to analyze 1.5T MRI scans. Behavioral disinhibition was measured using the Neuropsychiatric Inventory (Cummings, 1997; Cummings et al., 1994) Disinhibition Scale. The sample (n = 112) mean age was 65.40 (SD = 8.60) years, education was 16.64 (SD = 2.54) years, and Mini-Mental State Examination (MMSE; Folstein et al., 1975) was 26.63 (SD = 3.32). Hierarchical linear regressions were used for data analysis. Controlling for age, MMSE, and color naming, Stroop performance was not significantly associated with disinhibition (β = 0.01, ΔR² = 0.01, p = .29). Hierarchical regressions controlling for age, MMSE, color naming, intracranial volume, and temporal and parietal lobes, examined whether left or right hemisphere regions predict Stroop performance. Bilaterally, parietal lobe atrophy best predicted poorer Stroop (left: β = 0.0004, ΔR² = 0.02, p = .002; right: β = 0.0004, ΔR² = 0.02, p = .002). Of frontal regions, only dorsolateral prefrontal cortex atrophy predicted poorer Stroop (β = 0.001, ΔR² = 0.01, p = .03); left and right anterior cingulate cortex atrophy predicted better Stroop (left: β = -0.003, ΔR² = 0.01, p = .02; right: β = -0.004, ΔR² = 0.01, p = .02). These findings suggest Stroop performance is a poor measure of behavioral disinhibition and frontal lobe atrophy even among a relatively high-risk population. PsycINFO Database Record (c) 2011 APA, all rights reserved.

Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.

PubMed

Nakazawa, Takaya; Miyanoki, Yuta; Urano, Yasuomi; Uehara, Madoka; Saito, Yoshiro; Noguchi, Noriko

2017-05-01

24(S)-Hydroxycholesterol (24S-OHC) has diverse physiological and pathological functions. In particular, cytotoxic effects of 24S-OHC in neuronal cells are important in development of neurodegenerative diseases. 24S-OHC induces necroptosis-like cell death in SH-SY5Y cells expressing little caspase-8. In the present study, 24S-OHC was found to induce apoptosis as determined by caspase-3 activation in all-trans-retinoic acid (atRA)-treated SH-SY5Y cells in which expression of caspase-8 was induced. 24S-OHC-induced cell death was inhibited by α-tocopherol (α-Toc) but not by α-tocotrienol (α-Toc3) in SH-SY5Y cells regardless of whether cells were treated with atRA. In contrast, cumene hydroperoxide (CumOOH)-induced cell death was significantly inhibited by α-Toc and α-Toc3. In atRA-treated SH-SY5Y cells, generation of reactive oxygen species (ROS) was induced by stimulation with CumOOH but was not induced by stimulation with 24S-OHC. These results suggest that inhibition of 24S-OHC-induced cell death by α-Toc cannot be explained by its radical scavenging antioxidant activity. Esterification of 24S-OHC followed by lipid droplet (LD) formation due to acyl-CoA:cholesterol acyltransferase 1 (ACAT1) are key events in 24S-OHC-induced cell death in atRA-treated SH-SY5Y cells as demonstrated by inhibition of cell death by ACAT1 inhibitor. LD number was not changed by treatment with either α-Toc or α-Toc3. The different physical properties of α-Toc and α-Toc3 may account for their different inhibitory effects on 24S-OHC-induced cell death. Copyright © 2016 Elsevier Ltd. All rights reserved.

More than just a catchy title: The rewards and challenges of geoscience blogging

NASA Astrophysics Data System (ADS)

Ball, J. L.

2011-12-01

Social media have become increasingly important tools for communication, and no less so in the world of the Earth sciences. The "geoblogosphere", a collection of blogs written by geoscientists, began to grow quickly about four years ago and now encompasses more than three hundred blogs in multiple languages. The blog Magma Cum Laude (http://blogs.agu.org/magmacumlaude) was first published in 2007 among some of the earliest geoblogs, and is now part of the AGU Blogosphere, a widely read and lively blogging network. Originally intended as a chronicle of the author's time in graduate school and interest in volcanology, Magma Cum Laude's content has expanded to include science outreach, philanthropic ventures and interdisciplinary communication. In the process, the author has learned a great deal about how to develop and maintain a science blog, and how to integrate blogging with the demands of being a student and geoscientist. Geoblogging can be rewarding and fun, but it should also be approached with concrete goals and a clear understanding of potential drawbacks and difficulties. Geoscientists using social media have created new pathways for collaboration, peer review, science communication, and commentary on current events, making geoblogs a powerful supplement to 'traditional' research processes. In addition, geoblogging breaks down barriers between scientists and the public, demystifying research and giving the scientific community an opportunity to prove why its work is important. Geoblogs also have a lighter side - at any given time, there are a number of lively competitions, memes and conversations going on in the geoblogosphere. But like any social media outlet, blogging can present challenges, such as maintaining a good flow of content, integrating posting into a busy schedule, and dealing with interpersonal, employer and public responses. It is important to understand what these challenges entail, and how to deal with them, in order to utilize geoblogging to its considerable full potential.

Long distance electron-transfer mechanism in peptidylglycine alpha-hydroxylating monooxygenase: a perfect fitting for a water bridge.

PubMed

de la Lande, Aurélien; Martí, Sergio; Parisel, Olivier; Moliner, Vicent

2007-09-26

The active sites of copper enzymes have been the subject of many theoretical and experimental investigations from a number of years. Such studies have embraced topics devoted to the modeling of the first coordination sphere at the metallic cations up to the development of biomimetic, or bioinspired, catalytic systems. At least from the theoretical viewpoint, fewer efforts have been dedicated to elucidate how the two copper cations act concertedly in noncoupled dicopper enzymes such as peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-monooxygenase (DbetaM). In these metalloenzymes, an electronic transfer is assumed between the two distant copper cations (11 A). Recent experimental results suggest that this transfer occurs through water molecules, a phenomenon which has been theoretically evidenced to be of high efficiency in the case of cytochrome b5 (Science, 2005, 310, 1311). In the present contribution dedicated to PHM, we overpass the common theoretical approaches dedicated to the electronic and geometrical structures of sites CuM or CuH restricted to their first coordination spheres and aim at directly comparing theoretical results to the experimentally measured activity of the PHM enzyme. To achieve this goal, molecular dynamics simulations were performed on wild-type and various mutants of PHM. More precisely, we provide an estimate of the electron-transfer efficiency between the CuM and CuH sites by means of such molecular dynamics simulations coupled to Marcus theory joined to the Beratan model to approximate the required coupling matrix elements. The theoretical results are compared to the kinetics measurements performed on wild and mutated PHM. The present work, the dynamic aspects of which are essential, accounts for the experimental results issued from mutagenesis. It supports the conclusion that an electronic transfer can occur between two copper(I) sites along a bridge involving a set of hydrogen and chemical bonds. Residue Gln170 is evidenced to be the keystone of this water-mediated pathway.

EC97-43950-2

NASA Image and Video Library

1997-02-25

Bob Cummings, a technician at NASA's Dryden Flight Research Center, Edwards, California, checks out a new "Smart Skin" antenna mounted on the tip of the right vertical fin of Dryden's F/A-18 Systems Research Aircraft. Flight tests of the antenna system demonstrated a five-fold increase in voice communications range and a substantial improvement in the pattern of radiation and quality of transmission compared to the standard dorsal blade antenna on the aircraft. The Smart Skin antenna system was electrically as well as physically connected to the airframe, making the aircraft skin operate as an antenna along with the antenna itself. The concept was developed by TRW Avionics Systems Division and integrated into the F/A-18's vertical fin by Northrop-Grumman Corporation.

The Dirac-Moshinsky oscillator coupled to an external field and its connection to quantum optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torres, Juan Mauricio; Sadurni, Emerson; Seligman, Thomas H.

2010-12-23

The Dirac-Moshinsky oscillator is an elegant example of an exactly solvable quantum relativistic model that under certain circumstances can be mapped onto the Jaynes-Cummings model in quantum optics. In this work we show, how to do this in detail. Then we extend it by considering its coupling with an external (isospin) field and find the conditions that maintain solvability. We use this extended system to explore entanglement in relativistic systems and then identify its quantum optical analog: two different atoms interacting with an electromagnetic mode. We show different aspects of entanglement which gain relevance in this last system, which canmore » be used to emulate the former.« less

Optical programmable Boolean logic unit.

PubMed

Chattopadhyay, Tanay

2011-11-10

Logic units are the building blocks of many important computational operations likes arithmetic, multiplexer-demultiplexer, radix conversion, parity checker cum generator, etc. Multifunctional logic operation is very much essential in this respect. Here a programmable Boolean logic unit is proposed that can perform 16 Boolean logical operations from a single optical input according to the programming input without changing the circuit design. This circuit has two outputs. One output is complementary to the other. Hence no loss of data can occur. The circuit is basically designed by a 2×2 polarization independent optical cross bar switch. Performance of the proposed circuit has been achieved by doing numerical simulations. The binary logical states (0,1) are represented by the absence of light (null) and presence of light, respectively.

Conducting a children's divorce group: one approach.

PubMed

Rich, Beverly Waldman; Molloy, Pat; Hart, Bernadette; Ginsberg, Susan; Mulvey, Trudy

2007-08-01

The disruptive period around the time of the divorce can shatter a child's entire living milieu. An 8-week experiential children's group incorporating art and creative activities as well as a concurrent parent group is described. The aim of treatment was to bolster children's abilities to communicate with parents and other caretakers. Overall, participants were observed to effectively release painful affect, communicate more openly, and identify strengths in their family systems. Yalom's therapeutic group factors were incorporated into the treatment model. The research of Davies and Cummings related to children in the context of family therapy was also considered. Group leaders included advance practice registered nurses. Follow-up objective data collected from participants might provide further information about the efficacy of the interventions.

The Bayesian New Statistics: Hypothesis testing, estimation, meta-analysis, and power analysis from a Bayesian perspective.

PubMed

Kruschke, John K; Liddell, Torrin M

2018-02-01

In the practice of data analysis, there is a conceptual distinction between hypothesis testing, on the one hand, and estimation with quantified uncertainty on the other. Among frequentists in psychology, a shift of emphasis from hypothesis testing to estimation has been dubbed "the New Statistics" (Cumming 2014). A second conceptual distinction is between frequentist methods and Bayesian methods. Our main goal in this article is to explain how Bayesian methods achieve the goals of the New Statistics better than frequentist methods. The article reviews frequentist and Bayesian approaches to hypothesis testing and to estimation with confidence or credible intervals. The article also describes Bayesian approaches to meta-analysis, randomized controlled trials, and power analysis.

Relations between dissipated work and Rényi divergences in the generalized Gibbs ensemble

NASA Astrophysics Data System (ADS)

Wei, Bo-Bo

2018-04-01

In this work, we show that the dissipation in a many-body system under an arbitrary nonequilibrium process is related to the Rényi divergences between two states along the forward and reversed dynamics under a very general family of initial conditions. This relation generalizes the links between dissipated work and Rényi divergences to quantum systems with conserved quantities whose equilibrium state is described by the generalized Gibbs ensemble. The relation is applicable for quantum systems with conserved quantities and can be applied to protocols driving the system between integrable and chaotic regimes. We demonstrate our ideas by considering the one-dimensional transverse quantum Ising model and the Jaynes-Cummings model which are driven out of equilibrium.

Self-Assembled Cu-Sn-S Nanotubes with High (De)Lithiation Performance.

PubMed

Lin, Jie; Lim, Jin-Myoung; Youn, Duck Hyun; Kawashima, Kenta; Kim, Jun-Hyuk; Liu, Yang; Guo, Hang; Henkelman, Graeme; Heller, Adam; Mullins, Charles Buddie

2017-10-24

Through a gelation-solvothermal method without heteroadditives, Cu-Sn-S composites self-assemble to form nanotubes, sub-nanotubes, and nanoparticles. The nanotubes with a Cu 3-4 SnS 4 core and Cu 2 SnS 3 shell can tolerate long cycles of expansion/contraction upon lithiation/delithiation, retaining a charge capacity of 774 mAh g -1 after 200 cycles with a high initial Coulombic efficiency of 82.5%. The importance of the Cu component for mitigation of the volume expansion and structural evolution upon lithiation is informed by density functional theory calculations. The self-generated template and calculated results can inspire the design of analogous Cu-M-S (M = metal) nanotubes for lithium batteries or other energy storage systems.

Edgeworth expansions of stochastic trading time

NASA Astrophysics Data System (ADS)

Decamps, Marc; De Schepper, Ann

2010-08-01

Under most local and stochastic volatility models the underlying forward is assumed to be a positive function of a time-changed Brownian motion. It relates nicely the implied volatility smile to the so-called activity rate in the market. Following Young and DeWitt-Morette (1986) [8], we propose to apply the Duru-Kleinert process-cum-time transformation in path integral to formulate the transition density of the forward. The method leads to asymptotic expansions of the transition density around a Gaussian kernel corresponding to the average activity in the market conditional on the forward value. The approximation is numerically illustrated for pricing vanilla options under the CEV model and the popular normal SABR model. The asymptotics can also be used for Monte Carlo simulations or backward integration schemes.

Optimization of process parameters in CNC turning of aluminium alloy using hybrid RSM cum TLBO approach

NASA Astrophysics Data System (ADS)

Rudrapati, R.; Sahoo, P.; Bandyopadhyay, A.

2016-09-01

The main aim of the present work is to analyse the significance of turning parameters on surface roughness in computer numerically controlled (CNC) turning operation while machining of aluminium alloy material. Spindle speed, feed rate and depth of cut have been considered as machining parameters. Experimental runs have been conducted as per Box-Behnken design method. After experimentation, surface roughness is measured by using stylus profile meter. Factor effects have been studied through analysis of variance. Mathematical modelling has been done by response surface methodology, to made relationships between the input parameters and output response. Finally, process optimization has been made by teaching learning based optimization (TLBO) algorithm. Predicted turning condition has been validated through confirmatory experiment.

Imino-Oxy Acetic Acid Dealkylation as Evidence for an Inner-Sphere Alcohol Intermediate in the Reaction Catalyzed by Peptidylglycine α-Hydroxylating Monooxygenase (PHM)

PubMed Central

McIntyre, Neil R.; Lowe, Edward W.; Merkler, David J.

2009-01-01

Peptidylglycine α-hydroxylating monooxygenase (PHM, EC 1.14.17.3) catalyzes the stereospecific hydroxylation of a glycyl α-carbon in a reaction that requires O2 and ascorbate. Subsequent dealkylation of the α-hydroxyglycine by another enzyme, peptidylamidoglycolate lyase (PAL. EC 4.3.2.5), yields a bioactive amide and glyoxylate. PHM is a non-coupled, type II dicopper monooxygenase which activates O2 at only a single copper atom, CuM. In this study, the PHM mechanism was probed using a non-natural substrate, benzaldehyde imino-oxy acetic acid (BIAA). PHM catalyzes the O-oxidative dealkylation of BIAA to benzaldoxime and glyoxylate with no involvement of PAL. The minimal kinetic mechanism for BIAA was shown to be steady-state ordered using primary deuterium kinetic isotope effects. The D(V/K)APPARENT, BIAA decreased from 14.7 ± 1.0 as [O2] → 0 to 1.0 ± 0.2 as [O2] → ∞ suggesting the dissociation rate constant from the PHM·BIAA complex decreases as [O2] increases; thereby, reducing the steady-state concentration of [PHM]free. BIAA was further used to differentiate between potential oxidative Cu/O species using a QM/MM reaction coordinate simulation to determine which species could yield product O-dealkylation that matched our experimental data. The results of this study provided compelling evidence for the presence of a covalently linked CuII-alkoxide intermediate with a quartet spin state responsible BIAA oxidation. PMID:19569683

Mechanical Modulation of Nascent Stem Cell Lineage Commitment in Tissue Engineering Scaffolds

PubMed Central

Song, Min Jae; Dean, David; Tate, Melissa L. Knothe

2013-01-01

Taking inspiration from tissue morphogenesis in utero, this study tests the concept of using tissue engineering scaffolds as delivery devices to modulate emergent structure-function relationships at early stages of tissue genesis. We report on the use of a combined computational fluid dynamics (CFD) modeling, advanced manufacturing methods, and experimental fluid mechanics (micro-piv and strain mapping) for the prospective design of tissue engineering scaffold geometries that deliver spatially resolved mechanical cues to cells seeded within. When subjected to a constant magnitude global flow regime, the local scaffold geometry dictates the magnitudes of mechanical stresses and strains experienced by a given cell, and in a spatially resolved fashion, similar to patterning during morphogenesis. In addition, early markers of mesenchymal stem cell lineage commitment relate significantly to the local mechanical environment of the cell. Finally, by plotting the range of stress-strain states for all data corresponding to nascent cell lineage commitment (95% CI), we begin to “map the mechanome”, defining stress-strain states most conducive to targeted cell fates. In sum, we provide a library of reference mechanical cues that can be delivered to cells seeded on tissue engineering scaffolds to guide target tissue phenotypes in a temporally and spatially resolved manner. Knowledge of these effects allows for prospective scaffold design optimization using virtual models prior to prototyping and clinical implementation. Finally, this approach enables the development of next generation scaffolds cum delivery devices for genesis of complex tissues with heterogenous properties, e.g., organs, joints or interface tissues such as growth plates. PMID:23660249

Mechanical modulation of nascent stem cell lineage commitment in tissue engineering scaffolds.

PubMed

Song, Min Jae; Dean, David; Knothe Tate, Melissa L

2013-07-01

Taking inspiration from tissue morphogenesis in utero, this study tests the concept of using tissue engineering scaffolds as delivery devices to modulate emergent structure-function relationships at early stages of tissue genesis. We report on the use of a combined computational fluid dynamics (CFD) modeling, advanced manufacturing methods, and experimental fluid mechanics (micro-piv and strain mapping) for the prospective design of tissue engineering scaffold geometries that deliver spatially resolved mechanical cues to stem cells seeded within. When subjected to a constant magnitude global flow regime, the local scaffold geometry dictates the magnitudes of mechanical stresses and strains experienced by a given cell, and in a spatially resolved fashion, similar to patterning during morphogenesis. In addition, early markers of mesenchymal stem cell lineage commitment relate significantly to the local mechanical environment of the cell. Finally, by plotting the range of stress-strain states for all data corresponding to nascent cell lineage commitment (95% CI), we begin to "map the mechanome", defining stress-strain states most conducive to targeted cell fates. In sum, we provide a library of reference mechanical cues that can be delivered to cells seeded on tissue engineering scaffolds to guide target tissue phenotypes in a temporally and spatially resolved manner. Knowledge of these effects allows for prospective scaffold design optimization using virtual models prior to prototyping and clinical implementation. Finally, this approach enables the development of next generation scaffolds cum delivery devices for genesis of complex tissues with heterogenous properties, e.g., organs, joints or interface tissues such as growth plates. Copyright © 2013 Elsevier Ltd. All rights reserved.

Inner-sphere complexation of cations at the rutile-water interface: A concise surface structural interpretation with the CD and MUSIC model

NASA Astrophysics Data System (ADS)

Ridley, Moira K.; Hiemstra, Tjisse; van Riemsdijk, Willem H.; Machesky, Michael L.

2009-04-01

Acid-base reactivity and ion-interaction between mineral surfaces and aqueous solutions is most frequently investigated at the macroscopic scale as a function of pH. Experimental data are then rationalized by a variety of surface complexation models. These models are thermodynamically based which in principle does not require a molecular picture. The models are typically calibrated to relatively simple solid-electrolyte solution pairs and may provide poor descriptions of complex multi-component mineral-aqueous solutions, including those found in natural environments. Surface complexation models may be improved by incorporating molecular-scale surface structural information to constrain the modeling efforts. Here, we apply a concise, molecularly-constrained surface complexation model to a diverse suite of surface titration data for rutile and thereby begin to address the complexity of multi-component systems. Primary surface charging curves in NaCl, KCl, and RbCl electrolyte media were fit simultaneously using a charge distribution (CD) and multisite complexation (MUSIC) model [Hiemstra T. and Van Riemsdijk W. H. (1996) A surface structural approach to ion adsorption: the charge distribution (CD) model. J. Colloid Interf. Sci. 179, 488-508], coupled with a Basic Stern layer description of the electric double layer. In addition, data for the specific interaction of Ca 2+ and Sr 2+ with rutile, in NaCl and RbCl media, were modeled. In recent developments, spectroscopy, quantum calculations, and molecular simulations have shown that electrolyte and divalent cations are principally adsorbed in various inner-sphere configurations on the rutile 1 1 0 surface [Zhang Z., Fenter P., Cheng L., Sturchio N. C., Bedzyk M. J., Předota M., Bandura A., Kubicki J., Lvov S. N., Cummings P. T., Chialvo A. A., Ridley M. K., Bénézeth P., Anovitz L., Palmer D. A., Machesky M. L. and Wesolowski D. J. (2004) Ion adsorption at the rutile-water interface: linking molecular and macroscopic properties. Langmuir20, 4954-4969]. Our CD modeling results are consistent with these adsorbed configurations provided adsorbed cation charge is allowed to be distributed between the surface (0-plane) and Stern plane (1-plane). Additionally, a complete description of our titration data required inclusion of outer-sphere binding, principally for Cl - which was common to all solutions, but also for Rb + and K +. These outer-sphere species were treated as point charges positioned at the Stern layer, and hence determined the Stern layer capacitance value. The modeling results demonstrate that a multi-component suite of experimental data can be successfully rationalized within a CD and MUSIC model using a Stern-based description of the EDL. Furthermore, the fitted CD values of the various inner-sphere complexes of the mono- and divalent ions can be linked to the microscopic structure of the surface complexes and other data found by spectroscopy as well as molecular dynamics (MD). For the Na + ion, the fitted CD value points to the presence of bidenate inner-sphere complexation as suggested by a recent MD study. Moreover, its MD dominance quantitatively agrees with the CD model prediction. For Rb +, the presence of a tetradentate complex, as found by spectroscopy, agreed well with the fitted CD and its predicted presence was quantitatively in very good agreement with the amount found by spectroscopy.

inner-sphere complexation of cations at the rutile-water interface: A concise surface structural interpretation with the CD and MUSIC model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ridley, Mora K.; Hiemstra, T; Van Riemsdijk, Willem H.

Acid base reactivity and ion-interaction between mineral surfaces and aqueous solutions is most frequently investigated at the macroscopic scale as a function of pH. Experimental data are then rationalized by a variety of surface complexation models. These models are thermodynamically based which in principle does not require a molecular picture. The models are typically calibrated to relatively simple solid-electrolyte solution pairs and may provide poor descriptions of complex multicomponent mineral aqueous solutions, including those found in natural environments. Surface complexation models may be improved by incorporating molecular-scale surface structural information to constrain the modeling efforts. Here, we apply a concise,more » molecularly-constrained surface complexation model to a diverse suite of surface titration data for rutile and thereby begin to address the complexity of multi-component systems. Primary surface charging curves in NaCl, KCl, and RbCl electrolyte media were fit simultaneously using a charge distribution (CD) and multisite complexation (MUSIC) model [Hiemstra T. and Van Riemsdijk W. H. (1996) A surface structural approach to ion adsorption: the charge distribution (CD) model. J. Colloid Interf. Sci. 179, 488 508], coupled with a Basic Stern layer description of the electric double layer. In addition, data for the specific interaction of Ca2+ and Sr2+ with rutile, in NaCl and RbCl media, were modeled. In recent developments, spectroscopy, quantum calculations, and molecular simulations have shown that electrolyte and divalent cations are principally adsorbed in various inner-sphere configurations on the rutile 110 surface [Zhang Z., Fenter P., Cheng L., Sturchio N. C., Bedzyk M. J., Pr edota M., Bandura A., Kubicki J., Lvov S. N., Cummings P. T., Chialvo A. A., Ridley M. K., Be ne zeth P., Anovitz L., Palmer D. A., Machesky M. L. and Wesolowski D. J. (2004) Ion adsorption at the rutile water interface: linking molecular and macroscopic properties. Langmuir 20, 4954 4969]. Our CD modeling results are consistent with these adsorbed configurations provided adsorbed cation charge is allowed to be distributed between the surface (0-plane) and Stern plane (1-plane). Additionally, a complete description of our titration data required inclusion of outer-sphere binding, principally for Cl which was common to all solutions, but also for Rb+ and K+. These outer-sphere species were treated as point charges positioned at the Stern layer, and hence determined the Stern layer capacitance value. The modeling results demonstrate that a multi-component suite of experimental data can be successfully rationalized within a CD and MUSIC model using a Stern-based description of the EDL. Furthermore, the fitted CD values of the various inner-sphere complexes of the mono- and divalent ions can be linked to the microscopic structure of the surface complexes and other data found by spectroscopy as well as molecular dynamics (MD). For the Na+ ion, the fitted CD value points to the presence of bidenate inner-sphere complexation as suggested by a recent MD study. Moreover, its MD dominance quantitatively agrees with the CD model prediction. For Rb+, the presence of a tetradentate complex, as found by spectroscopy, agreed well with the fitted CD and its predicted presence was quantitatively in very good agreement with the amount found by spectroscopy.« less

Cueva Antón: A multi-proxy MIS 3 to MIS 5a paleoenvironmental record for SE Iberia

NASA Astrophysics Data System (ADS)

Zilhão, João; Ajas, Aurélie; Badal, Ernestina; Burow, Christoph; Kehl, Martin; López-Sáez, José Antonio; Pimenta, Carlos; Preece, Richard C.; Sanchis, Alfred; Sanz, Montserrat; Weniger, Gerd-Christian; White, Dustin; Wood, Rachel; Angelucci, Diego E.; Villaverde, Valentín; Zapata, Josefina

2016-08-01

Overlying a palustrine deposit of unknown age (complex FP), and protected from weathering and erosion inside a large cave/rock-shelter cavity, the sedimentary fill of Cueva Antón, a Middle Paleolithic site in SE Spain, corresponds in most part (sub-complexes AS2-to-AS5) to a ca.3 m-thick Upper Pleistocene terrace of the River Mula. Coupled with the constraints derived from the deposit's paleoclimatic proxies, OSL dating places the accumulation of this terrace in MIS 5a, and radiocarbon dates from the overlying breccia cum alluvium (sub-complex AS1) fall in the middle part of MIS 3; the intervening hiatus relates to valley incision and attendant erosion. The two intervals represented remain largely unknown in Iberia, where the archeology of the early-to-middle Upper Pleistocene is almost entirely derived from karst sites; Cueva Antón shows that this dearth of data, often interpreted in demographic terms, has depositional underpinnings ultimately determined by past climate variation. In early MIS 5a, the paleobotanical evidence indicates climate conditions similar to present, albeit wetter, followed by progressive cooling, reflected in the replacement of Aleppo pine by black pine and, at the very end, juniper-dominated landscapes - the latter characterizing also mid-MIS 3 times. The variation in sedimentary facies and composition of the mollusk assemblages reflects the changing position of the river channel relative to the back wall of the cave. Such changes represented the major constraint for the occupation of the site - most of the time inaccessible to terrestrial mammals, it was used throughout by the eagle-owl, explaining the abundance of rabbit bones. Human occupation occurred during a few, short windows of availability, and is reflected in well-preserved living floors defined by hearths, artefact scatters, and the remains of hunted herbivores. The stone tool assemblages are Middle Paleolithic, which, in Europe, implies a Neandertal identity for their makers and, hence, that Neandertals persisted in the region until GI 8. Cueva Antón's high-resolution record provides unique, critical information on the paleoenvironments and adaptations of humans in two short windows of time during which wetter conditions existed in SE Iberia, where arid or semi-arid climates prevailed through most of the Upper Pleistocene and the Holocene.

A link between deformation history and the orientation of reflective structures in the 2.68-2.83 Ga Opatica belt of the Canadian Superior Province

NASA Astrophysics Data System (ADS)

Bellefleur, G.; Calvert, A. J.; Chouteau, M. C.

1997-07-01

True three-dimensional reflector orientations can be derived from prestack seismic reflection data where a seismic profile is particularly crooked. This is accomplished by estimating a measure of coherency along travel time trajectories defined by the azimuth, dip, and depth of a reflector and the medium velocity. Results from Lithoprobe line 48, located in the Opatica belt of the Archean Superior Province, differentiate reflectors with two distinct orientations, which coincide with the attitudes of two deformational fabrics mapped at surface. Assuming a connection between reflectivity and strain induced by tectonic processes, the reflectors with NNE strikes and shallow dips toward the east are correlated with surface evidence for early west vergent thrusting in the Opatica belt. Other reflectors, which strike ENE-WSW and dip shallowly to the north and to the south, indicate that most of the reflectors in the southern Opatica and beneath the Abitibi greenstone belt at middle and lower crustal levels formed during a later, approximately N-S shortening event. Mantle reflections previously interpreted as a relict suture of an Archean subduction zone dip to the north at around 30°-45° and are also associated with this N-S event. The distribution of reflector orientations estimated at the crooked parts of line 48 indicates that much of the Opatica crust was reworked during the N-S shortening event, although a region of the middle and lower crust, characterized by the earlier D1 reflectors, is preserved in the central part of the belt.

Using the Abitibi Greenstone Belt to Understand Martian Hydrothermal Systems and the Potential for Biosignature Preservation in High Temperature Aqueous Environments

NASA Technical Reports Server (NTRS)

Hurowitz, J.; Abelson, J.; Allwood, A.; Anderson, R.; Atkinson, B.; Beaty, D.; Bristow, T.; Ehlmann, B.; Eigenbrode, J.; Grotzinger, J.;

[Nucleosynthesis, Rotation and Magnetism in Accreting Neutron Stars

NASA Technical Reports Server (NTRS)

Bildsten, Lars

2004-01-01

This is my final report on the NASA ATP grant on nucleosynthesis, rotation and magnetism in accreting neutron stars (NAG5-8658). In my last two reports, I summarized the science that I have accomplished, which covered a large range of topics. For this report, I want to point out the graduate students that were partially supported on this grant and where they are now. Andrew Cumming is an Assistant Professor of Physics at McGill University, Greg Ushomirsky is a researcher at MIT s Lincoln Laboratories, Dean Townsley is a postdoctoral researcher at Univ. of Chicago, Chris Deloye is a postdoctoral researcher at Northwestern University. The other two students, Phil Chang and Tony Piro, are still at UCSB and will be completing their PhD s in Summer 05 and Summer 06.

Neem leaves as a source of fertilizer-cum-pesticide vermicompost.

PubMed

Gajalakshmi, S; Abbasi, S A

2004-05-01

Vermicomposting of neem (Azadirachta indica A. Juss) was accomplished in "high-rate" reactors operated at the earthworm (Eudrilus eugeniae) densities of 62.5 and 75 animals per litre of reactor volume. Contrary to the fears that neem--a powerful nematicide--might not be palatable to the annelids, the earthworms fed voraciously on the neem compost, converting upto 7% of the feed into vermicompost per day. Indeed the worms grew faster and reproduced more rapidly in the neem-fed vermireactors than in the reactors fed with mango leaf litter earlier studied by the authors (Gajalakshmi et al., 2003). Another set of experiments on the growth, flowering, and fruition of brinjal (Solanum melongena) plants with and without fertilization with vermicompost, revealed that the vermicompost had a significantly beneficial impact.

The rise of homosexuality and the dawn of communism in Hong Kong film: 1993-1998.

PubMed

Grossman, A

2000-01-01

I have designed this essay as a general overview of the self-evident trend towards queer subject matter in the past decade in Hong Kong film, a trend that not only coincides historically with the 1997 handover to the Mainland but also frequently comes equipped with parent-child relationships that can be read as allegories for the colony's future as the "child" to its mother country. Queerness in HK films has both alternated between and combined indigenous forms of queerness and the imported Western variety; by charting courses through internationalized concepts of homosexuality, HK films have posited their queerness not only as an existential allegory of (post)colonialism but also as a claim (or hope) for a utopian sexuality cum utopian international politics.

Giving voice to African thought in medical research ethics.

PubMed

Tangwa, Godfrey B

2017-04-01

In this article, I consider the virtual absence of an African voice and perspective in global discourses of medical research ethics against the backdrop of the high burden of diseases and epidemics on the continent and the fact that the continent is actually the scene of numerous and sundry medical research studies. I consider some reasons for this state of affairs as well as how the situation might be redressed. Using examples from the HIV/AIDS and Ebola epidemics, I attempt to show that the marginalization of Africa in medical research and medical research ethics is deliberate rather than accidental. It is causally related, in general terms, to a Eurocentric hegemony derived from colonialism and colonial indoctrination cum proselytization. I end by proposing seven theses for the critical reflection and appraisal of the reader.

Does Propolis Help to Maintain Oral Health?

PubMed Central

Więckiewicz, Włodzimierz; Miernik, Marta; Więckiewicz, Mieszko; Morawiec, Tadeusz

2013-01-01

Propolis, known also as bee glue, is a wax-cum-resin substance which is created out of a mix of buds from some trees with the substance secreted from bee's glands. Its diverse chemical content is responsible for its many precious salubrious properties. It was used in medicine already in ancient Egypt. Its multiple applications during the centuries have been studied and described in details. The purpose of this study is to present the possible use of propolis in treatment of various diseases of oral cavity in their dental aspect. The paper presents properties and possible applications of bee glue depending on dental specialities. An overview of publications which appeared during the recent years will allow the reader to follow all the possibilities to apply propolis in contemporary dentistry. PMID:23365605

Outstanding student paper award at the 1996 Fall Meeting

NASA Astrophysics Data System (ADS)

The Planetology Section presented an Outstanding Student Paper Award at the AGU 1996 Fall Meeting in San Francisco, California, in December 1996. Elissa Koenig, presented a poster entitled “Mapping and Modeling of Radial Fracture Patterns on Venus.” Koenig graduated summa cum laude from Princeton University in 1991 with a B.S.E. form the Geological Engineering Program. She then spent a year as a Fulbright Scholar at the University of Auckland, New Zealand, where she studied the fluid dynamics of geyser eruptions. Elissa joined the Geomechanics Research Group at Stanford University in 1993 as an NSF Graduate Fellow, minoring in mechanical engineering. Her Ph.D. dissertation, titled “The Mechanics of Brittle Fracture and Faulting Venus,” explores the processes of both radial dike emplacement and strike-slip faulting.

Dynamic generation of light states with discrete symmetries

NASA Astrophysics Data System (ADS)

Cordero, S.; Nahmad-Achar, E.; Castaños, O.; López-Peña, R.

2018-01-01

A dynamic procedure is established within the generalized Tavis-Cummings model to generate light states with discrete point symmetries, given by the cyclic group Cn. We consider arbitrary dipolar coupling strengths of the atoms with a one-mode electromagnetic field in a cavity. The method uses mainly the matter-field entanglement properties of the system, which can be extended to any number of three-level atoms. An initial state constituted by the superposition of two states with definite total excitation numbers, |ψ〉 M1,and |ψ〉 M 2, is considered. It can be generated by the proper selection of the time of flight of an atom passing through the cavity. We demonstrate that the resulting Husimi function of the light is invariant under cyclic point transformations of order n =| M1-M2| .

Preparative isolation of oligomeric procyanidins from Hawthorn (Crataegus spp.).

PubMed

Zumdick, S; Petereit, F; Luftmann, H; Hensel, A

2009-04-01

The oligomeric procyanidins (OPC) from Hawthorn leaves and flowers (Crataegi folium cum flore) are considered to be in part responsible for the cardiotonic clinical activity of the herbal material. Effective methods for rapid isolation of these heterogenous oligomeric clusters with defined molecular weight as reference compounds are not published until now. Therefore the water soluble fraction of an acetone/water (7 + 3) extract of Hawthorn leaves and flowers was fractionated by a combination of MPLC on RP-18 material and preparative HPLC using a diol stationary phase. This procedure resulted in the effective isolation of procyanidins with a distinct degree of polymerization (DP) from dimers DP2 up to tridecamers DP13. Exact mass measurements with negative ESI-TOF/MS were employed to confirm the respective structures of the isolated procyanidins.

[The clinical study of percutaneous transhepatic radiofrequency ablation combined with tumor edge of percutaneous absolute ethanol injection on liver cancer adjacent to major blood vessels].

PubMed

Du, Jun-dong; Liu, Rong; Jiao, Hua-bo; Xiang, De-dong; Yin, Hui-nan; Li, Zhen-cai; Li, Tao; Zhu, Zi-man; Li, Zhan-liang

2011-05-01

To explore the effects of percutaneous transhepatic radiofrequency ablation (PRFA) combined with tumor edge of percutaneous absolute ethanol injection (PEI) on liver cancer adjacent to major blood vessels. Seventy five patients with liver cancer adjacent to major blood vessels were randomly divided into two groups: PRFA+PEI therapy group (38 cases) and PRFA control group (37 cases). Tumor necrosis rate, AFP levels, local recurrence rate, median for survival time and cum survival were used as the evaluation index to evaluate the efficacies of the two methods. Tumor necrosis rates of the therapy group and the control group were 84.2% and 54.1% (P < 0.01), respectively; AFP levels of therapy group and control group at 1, 3, 6 and 12 months after treatment were (105.0 ± 35.5) μg/L, (28.4 ± 4.3) μg/L, (58.6 ± 6.7) μg/L, (89.5 ± 12.5) μg/L and (137.2 ± 34.6) μg/L, (84.2 ± 18.4) μg/L, (106.6 ± 20.3) μg/L, (173.7 ± 32.0) μg/L, respectively. The rates of therapy group was significantly lower than of control group. Local recurrence rates of the therapy group and control group were 2.6%, 7.9%, 13.2% and 31.6% vs 10.8%, 21.6% , 40.5% and 62.1% (P < 0.05) at 3, 6, 12 and 24 months after treatment, respectively. Median for survival time of the therapy group and control group were 28.0 ± 2.8 months and 19.0 ± 3.6 months, respectively. Cum survival of the therapy group and control group were 84.2%, 78.9%, 60.5% and 31.6% vs 78.4%, 67.6%, 37.8% and 8.1% (P < 0.05) at 6, 12, 24 and 36 months after treatment, respectively. PEI as a supplementary treatment of PRFA can effectively improve the treatment of liver cancer adjacent to major blood vessels and significantly reduce the local recurrence rate and improve long-term survival rates.

400th Anniversary of Marius's Book with the First Image of an Astronomical Telescope and of Orbits of Jovian Moons

NASA Astrophysics Data System (ADS)

Pasachoff, Jay M.; Leich, Pierre

2015-01-01

Simon Mayr's (Marius's) Mundus Iovialis Anno M·DC·IX Detectus Ope Perspicilli Belgici (The World of Jupiter...) was published in Nuremberg in 1614; Marius was the Ansbach court mathematician. The frontispiece includes not only a portrait of Marius (1573-1624) himself but also, in the foreground, a long tube labelled "perspicillum," the first known image of a telescopic device used for astronomy; the name "telescope" came later. A schematic diagram of Jupiter with four moons orbiting appears at upper left; Marius, following a suggestion from Kepler, gave these Galilean satellites the names now still in use: Io, Europa. Ganymede, and Callisto. The title continues Hoc est, Quatuor Joviali cum Planetarum, cum Theoria, tum Tabulae, Propriis Observationibus Maxime Fundate.... A pair of conferences was held in Germany in 2014 to commemorate the 400th anniversary of Marius's book and to discuss Marius's work and its relation to Galileo's work (http://www.simon-marius.net; http://www.simon-marius.net/index.php?lang=en&menu=1 28 languages are available). Marius (Mayr) had independently discovered the four satellites of Jupiter, apparently one day after Galileo, on December 29 O.S., 1609; by the time he published his work four years later (a local-circulation publication had appeared in Nuremberg in 1611 in Prognosticon Astrologicum auf das Jahr 1612), Galileo had gained fame and priority, and Galileo accused Marius of plagiarism in Il Saggiatore (1623). With his Belgian telescope, Marius also noted the tilt of the orbital plane of Jupiter's moons, sunspots (1611), and the Andromeda Nebula (1612). He claimed to have worked out a system of cosmology similar to the Tychonic system in 1596, contemporaneously to Kepler's Mysterium Cosmographicum. A crater, the Marius Hills, and the Rima Marius on the Moon are named for him by the I.A.U., as well as, to celebrate the quadricentennial, a main-belt asteroid, now (7984) Marius. Acknowledgment: JMP thanks Seth Fagen, PRPH Books in New York, for introducing him to Marius's book 18 years ago.

Studies on improved integrated membrane-based chromatographic process for bioseparation

NASA Astrophysics Data System (ADS)

Xu, Yanke

To improve protein separation and purification directly from a fermentation broth, a novel membrane filtration-cum-chromatography device configuration having a relatively impermeable coated zone near the hollow fiber module outlet has been developed. The integrated membrane filtration-cum-chromatography unit packed with chromatographic beads on the shell side of the hollow fiber unit enjoys the advantages of both membrane filtration and chromatography; it allows one to load the chromatographic media directly from the fermentation broth or lysate and separate the adsorbed proteins through the subsequent elution step in a cyclic process. Interfacial polymerization was carried out to coat the bottom section of the hollow fiber membrane while leaving the rest of the hollow fiber membrane unaffected. Myoglobin (Mb), bovine serum albumin (BSA) and a-lactalbumin (a-LA) were used as model proteins in binary mixtures. Separation behaviors of binary protein mixtures were studied in devices using either an ultrafiltration (UF) membrane or a microfiltration (MF) membrane. Experimental results show that the breakthrough time and the protein loading capacities were dramatically improved after coating in both UF and MF modules. For a synthetic yeast fermentation broth feed, the Mb and a-LA elution profiles for the four consecutive cyclic runs were almost superimposable. Due to the lower transmembrane flux in this device plus the periodical washing-elution during the chromatographic separation, fouling was not a problem as it is in conventional microfiltration. A mathematical model describing the hydrodynamic and protein loading behaviors of the integrated device using UF membrane with a coated zone was developed. The simulation results for the breakthrough agree well with the experimental breakthrough curves. The optimal length of the coated zone was obtained from the simulation. A theoretical analysis of the protein mass transfer was performed using a diffusion-convection model considering the feed-side concentration polarization and the permeate-side concentration gradient formed by the adsorption. The permeate-side adsorption can enhance the observed protein transmission through the membrane considerably at low permeate flux. But the enhancement effect can be neglected at higher permeate flux when convection dominates the total mass transfer process or the proteins are very highly rejected by the membrane.

Re-Os systematics of komatiites and komatiitic basalts at Dundonald Beach, Ontario, Canada: Evidence for a complex alteration history and implications of a late-Archean chondritic mantle source

NASA Astrophysics Data System (ADS)

Gangopadhyay, A.; Sproule, R. A.; Walker, R. J.; Lesher, C.

2004-12-01

Re-Os concentrations and isotopic compositions have been examined in one komatiite unit and one komatiitic basalt unit at Dundonald Beach, which is part of the spatially-extensive 2.7 Ga Kidd-Munro volcanic assemblage in the Abitibi greenstone belt, Ontario, Canada. The komatiitic rocks in this locality record at least three episodes of alteration of Re-Os elemental and isotope systematics. First, an average of 40% and as much as 75% Re was lost due to shallow degassing during eruption and/or hydrothermal leaching during or immediately after the lava emplacement. Second, the Re-Os isotope systematics of the rocks with 187Re/188Os ratios >1 were reset at ˜2.5 Ga, most likely due to a regional metamorphic event. Finally, there is evidence for relatively recent gain and loss of Re. The variations in Os concentrations in the Dundonald komatiites yield a relative bulk distribution coefficient for Os (DOs solid/liquid) of 2-4, consistent with those obtained for stratigraphically-equivalent komatiites in the nearby Alexo area and in Munro Township. This suggests that Os was moderately compatible during crystal-liquid fractionation of the magma parental to the Kidd-Munro komatiitic rocks. Furthermore, whole-rock samples and chromite separates with low 187Re/188Os ratios (<1) yield a precise chondritic average initial 187Os/188Os ratio of 0.1083 ± 0.0006 (\\gammaOs = 0.0 ± 0.6). The chondritic initial Os isotopic composition of the mantle source for the Dundonald rocks is consistent with that determined for komatiites in the Alexo area and in Munro Township. Our Os isotope results for the Dundonald komatiitic rocks, combined with those in the Alexo and Pyke Hill areas suggest that the mantle source region for the Kidd- Munro volcanic assemblage had evolved along a long-term chondritic Os isotopic trajectory until their eruption at ˜2.7 Ga. The chondritic initial Os isotopic composition of the Kidd-Munro komatiites is indistinguishable from that of the projected contemporaneous convective upper mantle. The uniform chondritic Os isotopic composition of the ˜2.7 Ga mantle source for the Kidd-Munro komatiites contrasts with the typical large-scale Os isotopic heterogeneity in the mantle sources for komatiites from the Gorgona Island, present-day ocean island basalts or arc-related lavas. This suggests a significantly more homogeneous mantle source in the Archean compared to the presentday mantle.

Re-Os systematics of komatiites and komatiitic basalts at Dundonald Beach, Ontario, Canada: Evidence for a complex alteration history and implications of a late-Archean chondritic mantle source

NASA Astrophysics Data System (ADS)

Gangopadhyay, Amitava; Sproule, Rebecca A.; Walker, Richard J.; Lesher, C. Michael

2005-11-01

Osmium isotopic compositions, and Re and Os concentrations have been examined in one komatiite unit and two komatiitic basalt units at Dundonald Beach, part of the 2.7 Ga Kidd-Munro volcanic assemblage in the Abitibi greenstone belt, Ontario, Canada. The komatiitic rocks in this locality record at least three episodes of alteration of Re-Os elemental and isotope systematics. First, an average of 40% and as much as 75% Re may have been lost due to shallow degassing during eruption and/or hydrothermal leaching during or immediately after emplacement. Second, the Re-Os isotope systematics of whole rock samples with 187Re/ 188Os ratios >1 were reset at ˜2.5 Ga, possibly due to a regional metamorphic event. Third, there is evidence for relatively recent gain and loss of Re in some rocks. Despite the open-system behavior, some aspects of the Re-Os systematics of these rocks can be deciphered. The bulk distribution coefficient for Os (D Ossolid/liquid) for the Dundonald rocks is ˜3 ± 1 and is well within the estimated D values obtained for komatiites from the nearby Alexo area and stratigraphically-equivalent komatiites from Munro Township. This suggests that Os was moderately compatible during crystal-liquid fractionation of the magmas parental to the Kidd-Munro komatiitic rocks. Whole-rock samples and chromite separates with low 187Re/ 188Os ratios (<1) yield a precise chondritic average initial 187Os/ 188Os ratio of 0.1083 ± 0.0006 (γ Os = 0.0 ± 0.6) for their well-constrained ˜2715 Ma crystallization age. The chondritic initial Os isotopic composition of the mantle source for the Dundonald rocks is consistent with that determined for komatiites in the Alexo area and in Munro Township, suggesting that the mantle source region for the Kidd-Munro volcanic assemblage had evolved with a long-term chondritic Re/Os before eruption. The chondritic initial Os isotopic composition of the Kidd-Munro komatiites is indistinguishable from that of the projected contemporaneous convective upper mantle. The uniform chondritic Os isotopic composition of the Kidd-Munro komatiites contrasts with the typical large-scale Os isotopic heterogeneity in the mantle sources for ca. 89 Ma komatiites from the Gorgona Island, arc-related rocks and present-day ocean island basalts. This suggests that the Kidd-Munro komatiites sampled a late-Archean mantle source region that was significantly more homogeneous with respect to Re/Os relative to most modern mantle-derived rocks.

Fluid Characteristics in the Giant Quartz Reef System of the Bundelkhand Craton, India: Constraints from Fluid Inclusion Study

NASA Astrophysics Data System (ADS)

Rout, D.; Panigrahi, M. K.; Pati, J. K.

2017-12-01

Giant quartz reefs are anomalous features indicating extensive mobilization of silica in the crust. Such reefs in the Abitibi belt, Canada and elsewhere are believed to be the result of activity of fluid of diverse sources on terrain boundaries. The Bundelkhand granitoid complex constituting a major part of the Bundelkhnad Craton in north-Central India is traversed by numerous such quartz reefs all across for a length of about 500 km. There are about 20 major reefs having dimensions of 35 to 40 km in length, 50 to 60 m in width standing out as prominent ridges in the region. Almost all are aligned parallel to each other in a sub-vertical to vertical manner following the NE-SW to NNE-SSW trend. Fluid inclusion petrography in quartz from these reefs reveal four types of inclusions viz. aqueous biphase (type-I), pure carbonic (type-II), aqueous carbonic (type-III) and polyphase (type-IV) inclusions. The type-I aqueous biphase inclusions are the dominant type in all the samples studied so far. Salinities calculated from temperature of melting of last ice (Tm) values are low to moderate, ranging from 0.18 to 18.19 wt% NaCl equivalents. Temperature of liquid-vapor homogenization (Th) values of these inclusions show a wide range from 101 ºC to 386 ºC (cluster around 150-250 ºC) essentially into liquid phase ruling out boiling during its course of evolution. Besides, aqueous Biphase inclusions, some data on pure CO2 inclusions furnish a near constant value of TmCO2 at -56.6 ºC in the Bundelkhand Craton indicating absence of CH4. Bivariate plot between Th and salinity suggest three possible water types which are controlling the overall activity of fluid in quartz reefs of Bundelkhand Craton viz. low-T low saline, high-T low saline and moderate-T and moderate saline. A low saline and CO2-bearing and higher temperature nature resembles a metamorphic fluid that may be a source for these giant quartz reefs. The low temperature low-salinity component could be a meteoric fluid that possibly mixed with a moderate salinity fluid. Such a moderate salinity fluid could represent a magmatic fluid that evolved to such low temperatures through prolonged fluid rock interaction. Although these quartz reefs do not bear any economic grade mineralization, the fluid characteristics compare well with mineralized reefs in the Dharwar and Bastar cratons.

SU-G-TeP3-11: Radiobiological-Cum-Dosimetric Quality Assurance of Complex Radiotherapy Plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paudel, N; Narayanasamy, G; Zhang, X

2016-06-15

Purpose: Dosimetric gamma-analysis used for QA of complex radiotherapy plans tests the dosimetric equivalence of a delivered plan with the treatment planning system (TPS) optimized plan. It does not examine whether a dosimetric difference results in any radiobiological difference. This study introduces a method to test the radiobiological and dosimetric equivalence between a delivered and the TPS optimized plan. Methods: Six head and neck and seven lung cancer VMAT or IMRT plans optimized for patient treatment were calculated and delivered to an ArcCheck phantom. ArcCheck measured dose distributions were compared with the TPS calculated dose distributions using a 2-D gamma-analysis.more » Dose volume histograms (DVHs) for various patient structures were obtained by using measured data in 3DVH software and compared against the TPS calculated DVHs using 3-D gamma analysis. DVH data were used in the Poisson model to calculate tumor control probability (TCP) for the treatment targets and in the sigmoid dose response model to calculate normal tissue complication probability (NTCP) for the normal structures. Results: Two-D and three-D gamma passing rates among six H&N patient plans differed by 0 to 2.7% and among seven lung plans by 0.1 to 4.5%. Average ± SD TCPs based on measurement and TPS were 0.665±0.018 and 0.674±0.044 for H&N, and 0.791±0.027 and 0.733±0.031 for lung plans, respectively. Differences in NTCPs were usually negligible. The differences in dosimetric results, TCPs and NTCPs were insignificant. Conclusion: The 2-D and 3-D gamma-analysis based agreement between measured and planned dose distributions may indicate their dosimetric equivalence. Small and insignificant differences in TCPs and NTCPs based on measured and planned dose distributions indicate the radiobiological equivalence between the measured and optimized plans. However, patient plans showing larger differences between 2-D and 3-D gamma-analysis can help us make a more definite conclusion through our ongoing research with a larger number of patients.« less