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Sample records for curitiba pr brazil

  1. 222Rn Measurements at Federal University of Technology (UTFPR, Curitiba, PR, Brazil)

    NASA Astrophysics Data System (ADS)

    Corrêa, Janine Nicolosi; Paschuk, Sergei A.; Fior, Loriane; Schelin, Hugo R.; da Silva, Ruben D. Flores; Pöttker, Fabiana; de Paula Melo, Vicente

    2008-08-01

    Numerous studies and reports indicate that the indoor radon inhalation by humans has to be considered as the main source of radiological hazard and probably the second most important cause of lung cancer after that of smoking. During the last decades, many countries have put considerable efforts into direct measurements and monitoring of 222Rn and its progeny exposure, as well as 222Rn concentration mapping. Present measurements were performed with an aim to study possible correlation between used construction materials and 222Rn indoor concentration levels. For this purpose, 50 Lexan track detectors were exposed in the air (indoor as well as outdoor) during two months (June and July) within the central region of Curitiba and Campo Largo (Parana St., Brazil). Since this period of the year is usually rather cold in the South of Brazil, exposition time was chosen to prevent possible saturation of alpha tracks. The second step of measurements was performed during the months of November, December and January, when 50 Lexan track detectors were exposed in the air (indoor and outdoor) within the same urban area. Achieved results are being compared with other experimental data.

  2. {sup 222}Rn Measurements at Federal University of Technology (UTFPR, Curitiba, PR, Brazil)

    SciTech Connect

    Correa, Janine Nicolosi; Paschuk, Sergei A.; Fior, Loriane; Schelin, Hugo R.; Flores da Silva, Ruben D.; Poettker, Fabiana; Paula Melo, Vicente de

    2008-08-07

    Numerous studies and reports indicate that the indoor radon inhalation by humans has to be considered as the main source of radiological hazard and probably the second most important cause of lung cancer after that of smoking. During the last decades, many countries have put considerable efforts into direct measurements and monitoring of {sup 222}Rn and its progeny exposure, as well as {sup 222}Rn concentration mapping. Present measurements were performed with an aim to study possible correlation between used construction materials and {sup 222}Rn indoor concentration levels. For this purpose, 50 Lexan track detectors were exposed in the air (indoor as well as outdoor) during two months (June and July) within the central region of Curitiba and Campo Largo (Parana St., Brazil). Since this period of the year is usually rather cold in the South of Brazil, exposition time was chosen to prevent possible saturation of alpha tracks. The second step of measurements was performed during the months of November, December and January, when 50 Lexan track detectors were exposed in the air (indoor and outdoor) within the same urban area. Achieved results are being compared with other experimental data.

  3. Personal and behavioral factors associated with bicycling in adults from Curitiba, Paraná State, Brazil.

    PubMed

    Kienteka, Marilson; Reis, Rodrigo Siqueira; Rech, Cassiano Ricardo

    2014-01-01

    Bicycling is an important form of physical activity that can promote health benefits. The objective of this study was to analyze the association between personal and behavioral aspects in transportation bicycling and leisure time bicycling in adults. Data was drawn from a household survey involving 677 adults (53.1% female) in Curitiba, Paraná State, Brazil. The prevalence of bicycling was 11.2% for transportation and 16.7% for leisure. The frequency of leisure time bicycling was higher among men (PR = 2.08; p < 0.001), young people < 30 and adults aged between 30 and 39.9, bicycle owners (PR = 8.76; p < 0.001) and among the physically active. Transportation bicycling occurred more frequently among men (PR = 3.63; p < 0.001), individuals aged 30 to 39.9, those with a low socioeconomic status (PR = 5.00; p = 0.006), bicycle owners (PR = 10.2; p < 0.001) and individuals with a negative perception of their quality of life. The prevalence of bicycling is low in Curitiba considering its potential as a means of physical activity. Personal and behavioral factors were associated with each form of bicycling.

  4. Epidemiologic pattern of patients with neurocysticercosis diagnosed by computed tomography in Curitiba, Brazil.

    PubMed

    Grazziotin, Ana Laura; Fontalvo, Mariana Campos; Santos, Marilis Beckert Feijó; Monego, Fernanda; Grazziotin, Ana Line; Kolinski, Victor Hugo Zanini; Bordignon, Rodrigo Henrique; Biondo, Alexander Welker; Antoniuk, Affonso

    2010-04-01

    The aim of this study was to drawn an epidemiological pattern of neurocystisticercosis (NCC) patients diagnosed by computed tomography at the major private diagnostic center in Curitiba, Brazil. A total of 1,009 medical files of consecutive patients presenting neurological indications were diagnosed by computed tomography from July 2007 to April 2008. Patient data included sex, age, municipality and tomography findings were analysed by Epi-info version 6.0.1. software. Most patients (81.10%) were living in Curitiba. A total of 91/1,009 cases (9.02%) were considered positive to NCC; 88 (96.7%) patients had inactive form of NCC and only 3 (3.2%) patients had cysts in granulomatous process. No patients had both forms. The prevalence of NCC cases in studied group was greater in patients between 51 to 60 years old, however, difference between sex was not significant. This epidemiological pattern of NCC was similar to the first NCC study in Curitiba, performed in 1995-1996 with 9.24% of positive cases.

  5. Perceived environment and public open space use: a study with adults from Curitiba, Brazil

    PubMed Central

    2013-01-01

    Background The aim of this study was to investigate the association between the perceived environment and the use of public open spaces (POS). Methods A cross-sectional study with household surveys was conducted in 1,461 adults from Curitiba, Brazil interviewed in person. The perceived environment was evaluated with the Neighborhood Environment Walkability Scale, and the POS use was evaluated using the ordinal scale (increased use). Results The presence of interesting objects, heavy traffic, and the number of positive attributes of the environment was positively associated with POS use among men, and the presence of trees was associated with the use among women. Conclusions Managers should invest in the architectural attractiveness of neighborhoods and should plant and conserve trees to encourage POS use. PMID:23497221

  6. Child and adolescent abuse and neglect in the city of Curitiba, Brazil.

    PubMed

    da Silva Franzin, Lucimara Cheles; Olandovski, Márcia; Vettorazzi, Maria Lúcia Tozetto; Werneck, Renata Iani; Moysés, Samuel Jorge; Kusma, Solena Ziemer; Moysés, Simone Tetu

    2014-10-01

    Identify and analyze cases of child and adolescent abuse and neglect in Curitiba, Brazil. This is an exploratory descriptive study that takes a quantitative approach. Secondary data from the reporting registry of the Network for the Protection of Children and Adolescents at Risk for Violence in Curitiba, Brazil, dating from 2004 to 2009, were analyzed. Variables included the victims' sociodemographic profile, place of notification, type, nature and severity of abuse, information about the author of the aggression or abuse, and physical lesions. The frequency distribution and associations between the variables were analyzed using the Chi-square test at a 5% significance level. The analysis of 19,316 records showed that domestic violence, abuse and neglect directed against children and adolescents were the most frequently recorded situation, with 17,082 cases (88.4%) distributed in the following manner: neglect, with 9742 reports (57.0%); physical violence, with 1341 reports (7.9%); sexual violence, with 796 reports (4.7%); psychological violence, with 574 reports (3.4%); and abandonment, with 190 reports (1.1%). Of the total, 43.9% were considered severe cases. The most affected age group was between 5 and 14 years of age, with balance between genders. In the majority of cases, the mother was registered as the author of the abuse or neglect. Physical sequelae (20.2%) mostly affected the head and upper and lower limbs, with consequent lesions manifesting as bruises, cuts, and fractures. An increase in the visibility of domestic violence and children and adolescents abuse and neglect has been observed in the city during the last few years, suggesting the effectiveness of the reporting strategies proposed by the protection network. It is important to increase social security and public welfare policies to prevent child and adolescent abuse and neglect, focusing on family support. PMID:24661691

  7. Variable compensation in Primary Healthcare: a report on the experience in Curitiba, Rio de Janeiro, Brazil, and Lisbon, Portugal.

    PubMed

    Poli Neto, Paulo; Faoro, Nilza Teresinha; Prado Júnior, José Carlos do; Pisco, Luís Augusto Coelho

    2016-05-01

    How professionals are compensated may affect how they perform their tasks. Fixed compensation may take the form of wages, payment for productivity or capitation. In addition to fixed compensation, there are numerous mechanisms for variable compensation. This article describes the experience of Curitiba and Rio de Janeiro in Brazil, and Lisbon in Portugal, using different models of performance-based compensation. In all three of these examples, management felt the need to offer monetary reward to achieve certain goals. The indicators analyzed the structure, processes and outcomes, and assessed professionals individual and as part of healthcare teams. In Lisbon, variable compensation can be as high as 40% of the base wage, while in Curitiba and Rio de Janeiro it is limited to 10%. Despite the growing use of this management tool in Brazil and the world, further studies are required to analyze the effectiveness of variable compensation.

  8. Detection of Neospora sp. antibodies in cart horses from urban areas of Curitiba, Southern Brazil.

    PubMed

    Villalobos, Eliana Monteforte Cassaro; Furman, Keiko Endo; Lara, Maria do Carmo Custódio de Souza Hunold; Cunha, Elenice Maria Sequetin; Finger, Mariane Angélica; Busch, Ana Paula Brenner; de Barros Filho, Ivan Roque; Deconto, Ivan; Dornbusch, Peterson Triches; Biondo, Alexander Welker

    2012-01-01

    Neospora caninum is a protozoan parasite which affects dogs as definitive hosts and several mammalian species as intermediate hosts mainly causing abortions and central nervous system disorders. The reemerging population of cart horses for carrying recycling material in urban areas of major cities in Brazil may have an impact on disease spreading, and these animals may be used as sentinels for environmental surveillance. Thus, the present study investigated the frequency of Neospora sp. antibodies in cart horses from Curitiba and surrounding areas, Paraná State, Southern Brazil. IgG antibodies against Neospora sp. were detected using indirect fluorescence antibody test (IFAT), and titers equal to or higher than 1:50 were considered reactive. Of all samples, 14/97 (14.4%) were positive: 2/29 (6.9%) were younger than 5; 5/26 (19.2%) between 6 and 9; and 6/31 (19.4%) older than 10 years of age. One of the 11 animals with unknown age was positive (9.1%). Cart horses are likely to be more exposed to dog feces and to Neospora sp. oocyst contamination in urban settings and a lower frequency of disease in dogs may have a negative impact on horse infection risk in these areas.

  9. Sedimentary record of PAHs in the Barigui River and its relation to the socioeconomic development of Curitiba, Brazil.

    PubMed

    Machado, Karina S; Figueira, Rubens C L; Côcco, Lilian C; Froehner, Sandro; Fernandes, Cristovão V S; Ferreira, Paulo A L

    2014-06-01

    Concentrations of polycyclic aromatic hydrocarbons (PAHs) were determined in a sediment core collected from the Barigui River, in Curitiba, South Brazil. The USEPA's 16 priority PAH concentrations ranged from 39ng g(-1) to 2350ng g(-1) of dry sediment over a period that corresponds temporally to between ca. 1855 and 2011. The concentrations and patterns of PAH distribution changed over this time period and may be associated with several episodes in the Curitiba's history. Two major PAHs concentration peaks occurred in approximately 1910 and 1970, which might reflect population increases due to immigration programs in the 1890s and the sudden economic development that occurred in Brazil from 1960 to 1980, "The Economic Miracle Period", respectively. Isomeric ratios revealed that the PAHs had predominantly pyrolytic sources. The population, number of highways and electric energy consumption of Curitiba, as indices of socioeconomic development, were positively correlated with PAH deposition in the sediment core from 1855 to 1970, indicating the influence of socioeconomic development on the environmental load of sedimentary PAHs. PMID:24636886

  10. Sedimentary record of PAHs in the Barigui River and its relation to the socioeconomic development of Curitiba, Brazil.

    PubMed

    Machado, Karina S; Figueira, Rubens C L; Côcco, Lilian C; Froehner, Sandro; Fernandes, Cristovão V S; Ferreira, Paulo A L

    2014-06-01

    Concentrations of polycyclic aromatic hydrocarbons (PAHs) were determined in a sediment core collected from the Barigui River, in Curitiba, South Brazil. The USEPA's 16 priority PAH concentrations ranged from 39ng g(-1) to 2350ng g(-1) of dry sediment over a period that corresponds temporally to between ca. 1855 and 2011. The concentrations and patterns of PAH distribution changed over this time period and may be associated with several episodes in the Curitiba's history. Two major PAHs concentration peaks occurred in approximately 1910 and 1970, which might reflect population increases due to immigration programs in the 1890s and the sudden economic development that occurred in Brazil from 1960 to 1980, "The Economic Miracle Period", respectively. Isomeric ratios revealed that the PAHs had predominantly pyrolytic sources. The population, number of highways and electric energy consumption of Curitiba, as indices of socioeconomic development, were positively correlated with PAH deposition in the sediment core from 1855 to 1970, indicating the influence of socioeconomic development on the environmental load of sedimentary PAHs.

  11. Measurements of 222Rn activity in well water of the Curitiba metropolitan area (Brazil)

    NASA Astrophysics Data System (ADS)

    Corrêa, Janine N.; Paschuk, Sergei A.; Kappke, Jaqueline; Perna, Allan F. N.; França, Alana C.; Schelin, Hugo R.; Denyak, Valeriy

    2014-11-01

    Considering that 222Rn activity concentration in well water can contribute to indoor radon concentration levels, which represent a radiation risk for the public, measurements of 226Ra and 222Rn activity in well water in Curitiba, Paraná State, Brazil were performed. Each water sample was submitted to four measurements for radon concentration over an interval of three days. After two months, the same samples were submitted again to 222Rn concentration measurements with the objective of indirectly evaluating the amount of 226Ra in them. The 222Rn concentration measurements were performed with an AlphaGUARD radon monitor (SAPHYMO), and the 226Ra concentration was evaluated with the decay curves of 222Rn. Within a few hours after extraction, about 70% of water samples from monitored wells presented 222Rn concentration values above the limit of 11.1 Bq/L recommended by the EPA of the United States. The obtained activity values varied between 1.6 Bq/L and 215 Bq/L for radon concentration, and radium concentrations deviated within an interval of 0.50 Bq/L and 6.8 Bq/L. The results reveal that the biggest part of 222Rn found in water samples originated not from soluble 226Ra compounds but from gas exhalation by the soil and rocks adjacent to the well. The results point to the necessity of mitigation procedure development for better control of global alpha radioactivity in drinking water.

  12. Evaluation of the noise pollution in urban parks of Curitiba, Brazil

    NASA Astrophysics Data System (ADS)

    Ferreira, Andressa C.; Diniz, Fabiano B.; Paz, Elaine C.; Zannin, Paulo T.

    2001-05-01

    This work shows a study about the noise pollution found in six urban parks of Curitiba, Paran, Brazil. The equivalent noise levels (Leq) have been measured in points spread throughout the park, and interviews have been conducted with some park visitors. It has been found out that 52.48% out of the measurement sites did not satisfy the Municipal Law no. 10,625, which states the noise emission level of 55 dB(A) as the limit value for green areas. The results of the questionnaires applied to the local visitors have showed that 39% out of the interviewed people used to visit the park every day and that 75% out of them seek for the realization of a physical activity. During the realization of their activities in the parks, 22% out of the interviewed people pointed to the noise pollution as the source of annoyance and 28% out of them pointed the local security. In this sense, it has been verified that half of the analyzed parks were inserted in acoustically polluted areas, which incurs a real state depreciation in their vicinities.

  13. Measurements of indoor 222RN activity in dwellings and workplaces of Curitiba (Brazil)

    NASA Astrophysics Data System (ADS)

    Corrêa, Janine N.; Paschuk, Sergei A.; Del Claro, Flávia; Kappke, Jaqueline; Perna, Allan F. N.; Schelin, Hugo R.; Denyak, Valeriy

    2014-11-01

    The present work describes the results of systematic measurements of radon (222Rn) in residential environments and workplaces in the Metropolitan Region of Curitiba (Paraná State, Brazil) during the period 2004-2012. For radon in air activity measurements, polycarbonate Track Etch Detectors CR-39, mounted in diffusion chambers protected by borosilicate glass fiber filters, were used. After being exposed in air, the CR-39 detectors were submitted to a chemical etching in a 6.25 M NaOH solution at 70 °C for 14 h. The alpha particle tracks were identified and manually counted with an optical microscope, and with the results of previously performed calibrations, the indoor activity concentration of 222Rn was calculated. The calibration of CR-39 and the alpha particle tracks chemical development procedures were performed in collaboration the National Institute of Radiological Sciences (NIRS, Japan). The major part of indoor 222Rn concentration in residences was found to be below 100 Bq/m3. In the case of working places, all measurements of 222Rn concentrations were below 100 Bq/m3. These values are considered within the limits set by international regulatory agencies, such as the US EPA and ICRP, which adopt up to 148 and 300 Bq/m3 as upper values for the reference levels for radon gas activity in dwellings, respectively. The latest value of 300 Bq/m3 for radon activity in air is proposed by ICRP considering the upper value for the individual dose reference level for radon exposure of 10 mSv/yr.

  14. Built environment and physical activity for transportation in adults from Curitiba, Brazil.

    PubMed

    Hino, Adriano A F; Reis, Rodrigo S; Sarmiento, Olga L; Parra, Diana C; Brownson, Ross C

    2014-06-01

    The goal of this study was to assess the association between features of the built environment and levels of walking and cycling as forms of transportation in the city of Curitiba, Brazil. Data collection was conducted through a telephone survey in 2008. The International Physical Activity Questionnaire was used to identify walking or cycling as forms of transportation. The built environment characteristics were obtained through the Geographic Information System for 1,206 adults. Density indicators were computed, considering a radius of 500 m around each individual's household. For the accessibility measures, the shortest distance to selected built environment features (e.g., bus stop, bike path) was used. The association between characteristics of the environment and the practice of walking or cycling was assessed through logistic regressions. After considering individual characteristics, higher-income areas (OR = 0.56, 95 % CI = 0.41-0.76), higher density of Bus Rapid Transit stations (OR = 1.50, 95 % CI = 1.22-1.84), and the proportion of residential (OR = 1.25, 95 % CI = 1.02-1.53) and commercial (OR = 1.47, 95 % CI = 1.13-1.91) areas were associated with any walking prevalence (≥ 10 min/week). Higher access to bike paths (OR = 0.80, 95 % CI = 0.64-1.00) was inversely associated with walking at recommended levels (≥ 150 min/week). Higher-income areas (OR = 0.26, 95 % CI = 0.08-0.81), greater number of traffic lights (OR = 0.27, 95 % CI = 0.09-0.88), and higher land use mix (OR = 0.52, 95 % CI = 0.31-0.88) were inversely associated with cycling. The neighborhood built environment may affect active commuting among adults living in urban centers in middle-income countries.

  15. Molecular characterisation of newly identified HIV-1 infections in Curitiba, Brazil: preponderance of clade C among males with recent infections.

    PubMed

    Ferreira, João Leandro de Paula; Thomaz, Mariana; Rodrigues, Rosangela; Harrad, David; Oliveira, Cristina Mendes; Oliveira, Carmem Aparecida de Freitas; Batista, João Paulo Gervasio; Ito, Tomoko Sezazake; Brigido, Luis Fernando de Macedo

    2008-12-01

    As in many areas of Brazil, the AIDS epidemic in Curitiba is relatively stable, but surveillance is important to support public policy. The molecular characteristics of HIV may be instrumental for monitoring epidemic trends. We evaluated plasma HIV-1 RNA (n = 37) from 38 cases presenting with positive serology, who were among 820 consenting volunteers visiting the downtown counselling and serology testing centre. Seroprevalence was 4.6% (CI 95% 3.2-6.3) and the estimated HIV incidence, as defined by the BED assay, was 2.86 persons/years (CI 95% 1.04-4.68). An additional set of contemporaneous, anonymous samples from a local laboratory was also analysed (n = 20). Regions of the HIV-1 polymerase (n = 57) and envelope (n = 34) were evaluated for subtyping, determination of mosaic structure, primary drug resistance mutations (pDRM), envelope V3 loop motifs and amino acid signatures related to viral tropism. HIV-1 clade B was observed in 53% of cases; HIV-1C in 30% and BC mosaics in 14%, with one F genome and one CF mosaic. Clade C infection was associated with recent infections among males (p < 0.03). Stanford surveillance pDRM was observed in 8.8% of sequences, with 7% showing high level resistance to at least one antiretroviral drug. Tropism for CXCR4 co-receptor was predicted in 18% of envelope sequences, which were exclusively among clade B genomes and cases with serological reactivity to chronic infection.

  16. Polycyclic aromatic hydrocarbons (PAHs) in airborne particulate matter in Curitiba, Brazil and benzo(a)pyrene toxic equivalency factors (TEFs).

    PubMed

    Froehner, Sandro; Maceno, Marcell; Machado, Karina Scurupa; Malheiros, Andre

    2010-09-01

    The concentration of PAHs in particulate matter was investigated in the city of Curitiba, located in south of Brazil. Urban atmospheric particulate matter was collected at six sampling sites whose characteristics were representative of the prevailing conditions. The concentration of particulate matter varied from 11.02 to 177.27 ng/m(3). Particulate matter was basically composed of PAHs with 3 and 4 aromatic rings and it agrees with results of air quality monitoring performed in other cities around the world. Molecular ratios, such as (Benzo(ghi)Perilene/Indene(cd)Pyrene, B(ghi)P/I(cd)P, indicate that the source of PAHs is gasoline engines in the downtown area and diesel engines in surrounding sites representing a heavy traffic situation. It was also investigated the toxic level of particulate matter using the BaP equivalency factor. The BaP(eq) for all samples was between 0.42 to 1.12 ng/m(3). The equivalency BaP(eq) indicated low health risk associated with exposure to the total PAHs content in environmental air. PMID:20658413

  17. [Evaluative study of nursing consultation in the basic networks of Curitiba, Brazil].

    PubMed

    da Silva, Sandra Honorato; Cubas, Marcia Regina; Fedalto, Maira Aparecida; da Silva, Sandra Regina; Limas, Thaís Cristina da Costa

    2010-03-01

    The implementation of the electronic health record in the basic networks of Curitiba enabled an advance in the implementation of the nursing consultation and the ICNPCH, whose modeling uses the ICNP axes structure and the ICNPCH list of action. The objective of this study was to evaluate the nursing consultation from the productivity and assistance coverage perspective. The studied population was obtained from a secondary database of nursing consultations from April to June of 2005. The analysis was performed using the Datawarehouse and OLAP tool. The productivity per professional was found to be 2.5 consultations per day. Professionals use 16% of their daily work time with this activity and up to 27% of their potential per month. The ICNPCH was used in 21% of the consultations. There is a 0.08 consultation coverage per inhabitant for 6% of the population. The nursing consultation makes it possible to characterize the nurses' role in health care and a new professional position capable of affecting the construction of public politics.

  18. Indoor air quality of a museum in a subtropical climate: the Oscar Niemeyer museum in Curitiba, Brazil.

    PubMed

    Godoi, Ricardo H M; Carneiro, Barbara H B; Paralovo, Sarah L; Campos, Vania P; Tavares, Tania M; Evangelista, Heitor; Van Grieken, Rene; Godoi, Ana F L

    2013-05-01

    The assessment of damage to indoor cultural heritage, in particular by pollutants, is nowadays a major and growing concern for curators and conservators. Nevertheless, although many museums have been widely investigated in Europe, the effects of particulate matter and gaseous pollutants in museums under tropical and subtropical climates and with different economic realities are still unclear. An important portion of the world's cultural heritage is currently in tropical countries where both human and financial resources for preserving museum collections are limited. Hence, our aim is to assess the damage that can be caused to the artwork by pollution in hot and humid environments, where air quality and microclimatic condition differences can cause deterioration. As a case study, particulate matter as well as gases were collected at the Oscar Niemeyer Museum (MON) in Curitiba, Brazil, where large modern and contemporary works of art are displayed. NO2, SO2, O3, Acetic Acid, Formic Acids and BTEX, in the ambient air, were sampled by means of passive diffusive sampling and their concentrations were determined by IC or GC-MS. The particulate matter was collected in bulk form and analyzed with the use of energy dispersive X-ray fluorescence and aethalometer. The chemical compositions of individual particles were quantitatively elucidated, including low-Z components like C, N and O, as well as higher-Z elements, using automated electron probe microanalysis. The gaseous and particulate matter levels were then compared with the concentrations obtained for the same pollutants in other museums, located in places with different climates, and with some reference values provided by international cultural heritage conservation centers. Results are interpreted separately and as a whole with the specific aim of identifying compounds that could contribute to the chemical reactions taking place on the surfaces of artifacts and which could potentially cause irreversible damage to the

  19. Microbiological quality of water from the rivers of Curitiba, Paraná State, Brazil, and the susceptibility to antimicrobial drugs and pathogenicity of Escherichia coli.

    PubMed

    Giowanella, Melissa; Bozza, Angela; do Rocio Dalzoto, Patricia; Dionísio, Jair Alves; Andraus, Sumaia; Guimarães, Edson Luiz Gomes; Pimentel, Ida Chapaval

    2015-11-01

    Water safety is determined by several markers, and Escherichia coli is one of the most important indicators of water quality. The objective of this study was to evaluate the microbiological parameters in environmental samples of fresh water from rivers of Curitiba and its metropolitan area in Paraná State, Brazil. In addition, we evaluated the pathogenicity and susceptibility to antimicrobial drugs in E. coli. These evaluations were performed by quantitative and qualitative methods employing selective media for isolating thermotolerant coliforms and biochemical tests for identifying E. coli. Pathogenic strains of E. coli were detected by PCR multiplex using specific primers. From the water samples, 494 thermotolerant coliforms were obtained, of which 96 (19.43%) isolates were characterized as E. coli. Three isolates were identified as enteroaggregative E. coli, one as enterotoxigenic E. coli, one as enteropathogenic E. coli, and two carried the Eae virulence gene. E. coli susceptibility to commonly employed antimicrobial drugs was analyzed by the disc diffusion method. The results showed 49 (51.04%) isolates resistant to all the drugs assayed, 16 (16.67%) with an intermediate resistance to all drugs, and 31 (32.29%) intermediately or fully resistant to one or more drugs tested. The highest rate of resistance was observed for tetracycline 30 μg, streptomycin 10 μg, and ceftazidime 30 μg. Detection of E. coli is associated with water contamination by fecal material from humans and warm-blooded animals. The occurrence of resistant strains can be the result of the indiscriminate use of antimicrobial drugs and poor sanitation in the areas assayed.

  20. Microbiological quality of water from the rivers of Curitiba, Paraná State, Brazil, and the susceptibility to antimicrobial drugs and pathogenicity of Escherichia coli.

    PubMed

    Giowanella, Melissa; Bozza, Angela; do Rocio Dalzoto, Patricia; Dionísio, Jair Alves; Andraus, Sumaia; Guimarães, Edson Luiz Gomes; Pimentel, Ida Chapaval

    2015-11-01

    Water safety is determined by several markers, and Escherichia coli is one of the most important indicators of water quality. The objective of this study was to evaluate the microbiological parameters in environmental samples of fresh water from rivers of Curitiba and its metropolitan area in Paraná State, Brazil. In addition, we evaluated the pathogenicity and susceptibility to antimicrobial drugs in E. coli. These evaluations were performed by quantitative and qualitative methods employing selective media for isolating thermotolerant coliforms and biochemical tests for identifying E. coli. Pathogenic strains of E. coli were detected by PCR multiplex using specific primers. From the water samples, 494 thermotolerant coliforms were obtained, of which 96 (19.43%) isolates were characterized as E. coli. Three isolates were identified as enteroaggregative E. coli, one as enterotoxigenic E. coli, one as enteropathogenic E. coli, and two carried the Eae virulence gene. E. coli susceptibility to commonly employed antimicrobial drugs was analyzed by the disc diffusion method. The results showed 49 (51.04%) isolates resistant to all the drugs assayed, 16 (16.67%) with an intermediate resistance to all drugs, and 31 (32.29%) intermediately or fully resistant to one or more drugs tested. The highest rate of resistance was observed for tetracycline 30 μg, streptomycin 10 μg, and ceftazidime 30 μg. Detection of E. coli is associated with water contamination by fecal material from humans and warm-blooded animals. The occurrence of resistant strains can be the result of the indiscriminate use of antimicrobial drugs and poor sanitation in the areas assayed. PMID:26439126

  1. Curitiba: Towards sustainable urban development

    SciTech Connect

    Rabinovitch, J.

    1995-12-31

    Curitiba is best known for its innovative public transport system based on buses but this is only one among many initiatives which have improved the environment and quality of life in the city, limited pollution and waste and reduced resource use. The public transport system has also been complemented by comprehensive initiatives in planning and land use management. This paper describes not only the development of the public transport system but also the planning and administrative framework that was needed to make it, and other initiatives taken in Curitiba, effective.

  2. The Audiometric Findings among Curitiba and Metropolitan Area Students

    PubMed Central

    Klas, Regina; Lacerda, Adriana

    2014-01-01

    Introduction Hearing loss can compromise the language, learning process, and socialization of students. Objective Study the audiometric findings among Curitiba and Metropolitan Area students. Methods Analysis of data collected at the hearing health service of Paraná State special education and inclusion department. Results The sample consisted of 646 students, children and teenagers of both genders (38.2% female and 61.8% male), with average age of 8.12 years (range 2 to 15); all were students of public or private schools of Curitiba and Metropolitan Area. The justifications to refer the students to audiometric evaluation were: otolaryngologists diagnosis (73.1%), school difficulties (39.6%), and midlevel hearing problems (32%). Audiometric results showed that 29.5% of the students had hearing loss. Conductive hearing losses showed the greatest occurrence among preschool students (right ear 38.6%, left ear 39.8%). The predominant hearing loss degree was mild (RE 20.5%, LE 19.3%) to slight (RE 17%, LE 19.3%), as was the horizontal configuration (RE 81.5%, LE 78.4%). A significant relationship (p = 0.0000) between hearing loss and poor school performance was noted. Conclusion Considering the available data, especially the high number of findings of conductive losses, it is necessary to highlight prevention and diagnosis of early hearing alteration. Nevertheless, Brazil, as an emerging country, has been pursuing improvement in health and life quality of all citizens. PMID:25992085

  3. [Banality of urbanism: the lesson of Curitiba].

    PubMed

    Piccinato, G

    1996-01-01

    Curitiba, the capital of the predominantly agricultural Brazilian state of Parana, is described as a smoothly functioning city where daily life is pleasant, nature and architecture are in harmony, and public spaces are neither deserted nor congested. The events permitting its satisfactory development are described in this article. Since rapid growth began in the 1960s, Curitiba has become an important commercial and industrial center and node for transportation and transformation of agricultural products. A city plan proposed in 1942 established a system of specialized zones for commerce, industry, housing and agriculture, tied together by a system of roads. The plan was modified in the 1960s to incorporate a series of innovations and has remained in force since, with periodic adjustments. The plan replaced a nodal structure with a lineal one, with a close integration of land use and transportation systems. The plan was designed to decongest the central area, define physical limits of growth, provide economic aid for urban development, and distribute resources equitably. The plan is similar to many others; much of Curitiba's success as a city is due to the plan's actually having been followed. Coherent urban policies based on the plan were directed by the Institute of Research and Urban Planning of Curitiba.

  4. [Banality of urbanism: the lesson of Curitiba].

    PubMed

    Piccinato, G

    1996-01-01

    Curitiba, the capital of the predominantly agricultural Brazilian state of Parana, is described as a smoothly functioning city where daily life is pleasant, nature and architecture are in harmony, and public spaces are neither deserted nor congested. The events permitting its satisfactory development are described in this article. Since rapid growth began in the 1960s, Curitiba has become an important commercial and industrial center and node for transportation and transformation of agricultural products. A city plan proposed in 1942 established a system of specialized zones for commerce, industry, housing and agriculture, tied together by a system of roads. The plan was modified in the 1960s to incorporate a series of innovations and has remained in force since, with periodic adjustments. The plan replaced a nodal structure with a lineal one, with a close integration of land use and transportation systems. The plan was designed to decongest the central area, define physical limits of growth, provide economic aid for urban development, and distribute resources equitably. The plan is similar to many others; much of Curitiba's success as a city is due to the plan's actually having been followed. Coherent urban policies based on the plan were directed by the Institute of Research and Urban Planning of Curitiba. PMID:12348996

  5. Interior noise profile of buses in Curitiba

    NASA Astrophysics Data System (ADS)

    Zannin, Paulo H. T.; Giovanini, Clifton R.; Diniz, Fabiano B.; Ferreira, Jose C.

    2002-11-01

    Evaluating the noise levels to which the bus drivers of Curitiba are exposed to during their working days is the main scope of this study. The city is served by an internationally known public transportation system featuring 1902 buses, which attend 1.9 million people per day. Two measurements have been taken inside each one of the 60 buses surveyed, one close to the driver and another one at the back of the bus. The results have showed that the dose levels the drivers are exposed to were below 50% in 92% out of the buses, but the normalized exposure levels were over 65 dB(A) in all cases. This level is considered as the threshold of comfort according to the Brazilian legislation on occupancy health NR-17--Ergonomics. The surveyed buses have been divided into three categories, according to their characteristics: feeder, rapid, and bi-articulated. A total of 20 buses within each category have been surveyed. Among the different categories, it has been found that the feeders have presented the highest noise levels. (To be presented in Portuguese.)

  6. [Educational status and patterns of weight gain in adulthood in Brazil: Estudo Pró-Saúde].

    PubMed

    Fonseca, Maria de Jesus Mendes da; França, Rosana de Figueiredo; Faerstein, Eduardo; Werneck, Guilherme Loureiro; Chor, Dóra

    2012-11-01

    The aim of the present study was to investigate the association between participant and parental educational status (considered as an indicator of socioeconomic status) and participant pattern of weight gain in adulthood. We analyzed data from 2 582 baseline participants (1999) of Estudo Pró-Saúde (Pro-Health Study), a longitudinal investigation of civil servants from a public university in Rio de Janeiro, Brazil. Self-administered questionnaires were used to identify patterns of weight gain in adulthood. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated for the association between parental and participant educational status and steady weight gain or weight cycling, with stable weight as a reference, using multinomial logistic regression models. For males, lower paternal educational level entailed a chance about 55% lower of weight cycling as compared to stable weight (OR = 0.45; IC95% = 0.26-0.78), whereas lower maternal schooling was related to increased risk of weight cycling, although without reaching statistical significance (OR = 1.68; IC95% = 0.94-3.00). The association between participant educational status and weight history was not statistically significant among men. In women, lower educational status entailed a chance 94% higher of self-reported weight cycling (OR = 1.94; 95% CI = 1.17-3.23), and there was no association between parental educational level and history of weight gain. In this study, changes in weight throughout life, both steady and cyclic, were associated with parental and participant educational status, with major differences between genders.

  7. Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil.

    PubMed

    Vidal, Luine Rosele Renaud; Almeida, Sérgio Monteiro de; Messias-Reason, Iara José de; Nogueira, Meri Bordignon; Debur, Maria do Carmo; Pessa, Luís Felipe Cavalli; Pereira, Luciane Aparecida; Rotta, Indianara; Takahashi, Gislene Reche de Almeida; Silveira, Clyete Santos da; Araújo, Josianne Maria Reimann; Raboni, Sonia Mara

    2011-06-01

    Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to December 2006, 460 cerebrospinal fluid (CSF) samples with lymphomonocytary meningitis were analyzed by PCR methodologies. Fifty nine (12.8%) samples were positive. Enteroviruses was present in 49 (83%) samples and herpes virus family in 10 (17%), of these 6 (10%) herpes simplex virus, 1 (2%) Epstein Barr virus, 2 (3%) human herpes virus type 6 and 1 (2%) mixed infection of enterovirus and Epstein Barr virus. As conclusion enterovirus was the most frequent virus, with circulation during summer and was observed with higher frequency between 4 to 17 years of age. PCR methodology is an important method for rapid detection of RNA enterovirus and DNA herpesvirus in CSF.

  8. Neighborhood and postal worker characteristics associated with dog bites in postal workers of the Brazilian National Postal Service in Curitiba.

    PubMed

    de Oliveira, Eduardo Alexandre; Manosso, Rose Maria; Braune, Gisela; Marcenovicz, Priscila Cavalheiro; Kuritza, Leandro Nagae; Ventura, Henrique Larsen Brunow; Paploski, Igor Adolfo Dexheimer; Kikuti, Mariana; Biondo, Alexander Welker

    2013-05-01

    Dog bites are the third most common cause of absenteeism among postal workers of the Brazilian National Postal Service in Southern Brazil, with an average off-work time of approximately two days for each biting episode. The objective of this study was to evaluate the neighborhood characteristics involving dog bites that occurred during work time in postal workers, its impact on work and consequent preventive alternatives. A descriptive and analytical cross-sectional study was designed for all Curitiba postal workers. Data were descriptively analyzed and the hypothesis of correlation between median monthly income, population density and occurrence of dog bites was tested. A total of 34.9% of the postal workers answered the questionnaire and 64.6% of them had been bitten while working. The odds of bites occurring in a neighborhood increase by 1.035 times for every increase in one unit in the population density and decrease by 0.998 times for every increase of US$ 1.00 in the neighborhood median monthly income of the head of the family. The occurrence of dog bites among postal workers in Curitiba is related to income and population density and prevention strategies should address mailbox position and adequate fencing to provide protection for postal workers.

  9. Brazil.

    PubMed

    1985-09-01

    Brazil's population in 1985 was 135 million, with an annual growth rate (1982) of 2.3%. The infant mortality rate (1981) was 92/1000, and life expectancy stood at 62.8 years. 76% of the adult population was literate. Brazil is a federal republic which recognizes 5 political parties. 55% of the population is Portuguese, Italian, German, Japanese, African, or American Indian; 38% is white. Of the work force of 50 million, 35% are engaged in agriculture, 25% work in industry, and 40% are employed in services. Trade union membership totals 6 million. The agricultural sector accounts for 12% of the GDP and 40% of exports. Brazil is largely self-sufficient in terms of food. The GDP was US$218 billion in 1984, with an annual growth rate of 4%. Per capita GDP was US$1645. Brazil's power, transportation, and communications systems have improved greatly in recent years, providing a base for economic development. High inflation rates have been a persistent problem.

  10. Brazil.

    PubMed

    1983-07-01

    Attention in this discussion of Brazil focuses: the history of the country's demographic situation; government's overall approach to population problems; population data systems and development planning; institutional arrangements for the integration of population within development planning; government's view of the importance of population policy in achieving development objectives; population size, growth, and natural increase; fertility; international migration; and spatial distribution. The population of Brazil grew from 17 million in 1900 to about 119 million in 1960, making it the most populous country in the world and 1 of the relatively few countries to have sustained rates of population growth of more than 2% for over a century. The government has not adopted an explicit policy to modify fertility or population growth. Initially this was because of its positive perception of the benefits of population growth and a large population size and, amore recently, because of Brazil's gradual transition to more moderate levels of fertility and population growth. Brazil's main sources of demographic data are its 9 censuses, conducted in 1982, 1890, 1900, 1920, 1940, 1950, 1960, 1970, and most recently in August 1980. A nationwide system of vital registration data are still lacking in many geographic areas, researchers have had to rely on indirect estimation techniques to derive estimates of past trends in fertility and mortality. Population policy has been regarded as a highly sensitive issue by Brazilian officials, and the government remains cautious in regard to population issues. Preliminary results of Brazil's 1980 census indicate a population of 119 million and an annual rate of population growth of 2.1%, continuing the downward trend that was first evident in 1976. The government considers levels and trends of population growth to be satisfactory, and morbidity and mortality to be unacceptable, partly because of a lack of success in reducing the incidence of

  11. [Bolsa-Família Program: diet quality of adult population in Curitiba, Paraná].

    PubMed

    Lima, Flávia Emília Leite de; Fisberg, Regina Mara; Uchimura, Kátia Yumi; Picheth, Telma

    2013-03-01

    This study evaluated the quality of diet of the population receiving the Bolsa Familia Program in Curitiba, state of Parana, Brazil. It was a population-based cross-sectional study, conducted from July 2006 to July 2007. 747 beneficiaries were interviewed from 19 years of age, of both genders. A 24 hour-recall was implemented in order to assess the quality of the diet and the Healthy Eating Index (HEI) was used as a parameter for the classification of the group in consumption levels. Descriptive statistics were used to describe the diet quality of the studied population. Wald test and ANOVA test were performed to compare the means of the index according to the socio-economic variables, considering a significance level of 5%. The sample comprised 91.4% of women and 8.6% of men. The average age of the population was 36.4 ± 13.3 years, with 75% having completed elementary school. The mean HEI was 51 points, which features a diet that needs improvement. The population has a monotonous diet with an adequate intake of legumes, but low for fruits, vegetables and dairy products. Comparing the categories of diet quality of individuals, all components, except sodium, showed statistically different median score (p < 0.01). Studies that evaluate the quality of the diet are essential to support the implementation of nutrition education programs targeted to the core of the problem in the populations studied.

  12. High Blood Pressure in Adolescents of Curitiba: Prevalence and Associated Factors

    PubMed Central

    Bozza, Rodrigo; de Campos, Wagner; Barbosa Filho, Valter Cordeiro; Stabelini Neto, Antonio; da Silva, Michael Pereira; Maziero, Renato Silva Barbosa

    2016-01-01

    Background Arterial hypertension is a major public health problem and has increased considerably in young individuals in past years. Thus, identifying factors associated with this condition is important to guide intervention strategies in this population. Objective To determine high blood pressure prevalence and its associated factors in adolescents. Methods A random sample of 1,242 students enrolled in public schools of the city of Curitiba (PR) was selected. Self-administered questionnaires provided family history of hypertension, daily energy expenditure, smoking habit, daily fat intake, and socioeconomic status. Waist circumference was measured following standardized procedures, and blood pressure was measured with appropriate cuffs in 2 consecutive days to confirm high blood pressure. Relative frequency and confidence interval (95%CI) indicated high blood pressure prevalence. Bivariate and multivariate analyses assessed the association of risk factors with high blood pressure. Results The high blood pressure prevalence was 18.2% (95%CI 15.2-21.6). Individuals whose both parents had hypertension [odds ratio (OR), 2.22; 95%CI 1.28-3.85] and those with high waist circumference (OR, 2.1; 95%CI 1.34-3.28) had higher chances to develop high blood pressure. Conclusion Positive family history of hypertension and high waist circumference were associated with high blood pressure in adolescents. These factors are important to guide future interventions in this population. PMID:27058256

  13. Evaluation of the health risks to garment workers in the city of Xambrê-PR, Brazil.

    PubMed

    Sant'Ana, Marco Antônio; Kovalechen, Fabrício

    2012-01-01

    This study evaluated the risks for cardiovascular disease and the life habits of garment industry workers in northwestern Paraná state, Brazil. The following parameters were assessed: body composition, cardiorespiratory fitness, eating habits and physical activities by garment industry workers. Cardiovascular risk was observed in some of the studied subjects, in the form of high BMI and reduced maximal oxygen uptake. The development of a workplace quality-of-life program is suggested, aiming to stimulate the development of physical activities to improve the cardiovascular conditioning of workers.

  14. PRENATAL DENTAL CARE: EVALUATION OF PROFESSIONAL KNOWLEDGE OF OBSTETRICIANS AND DENTISTS IN THE CITIES OF LONDRINA/PR AND BAURU/SP, BRAZIL, 2004

    PubMed Central

    Zanata, Régia Luzia; Fernandes, Karen Barros Parron; Navarro, Patrícia Silva Lopes

    2008-01-01

    The purpose of this study was to assess the current knowledge and recommendations of obstetricians and dentists as to the dental care to pregnant patients in the cities of Londrina/PR and Bauru/SP, Brazil. Questionnaires were distributed to professionals of both cities, arguing on the following issues: oral health during pregnancy; contact between prenatal care and dental care providers; prenatal fluoride supplementation; selection of therapeutic agents for local anesthesia, pain control and treatment of infection; and dental procedures that can be performed during each trimester. Data were analyzed by frequency of responses and statistical analyses were carried out using X2 (type of workplace/service) and t test (time since graduation), significant if p<0.05. Seventy-nine obstetricians and 37 dentists responded the questionnaires. Most physicians referred the patient to dental care only when a source of dental problem was mentioned, limiting the adoption of a preventive approach. Forty-three percent of dentists and 34% of obstetricians did not know the potential contribution of periodontal infection as a risk factor for preterm low birth-weight babies. There was divergence from scientific literature as to the recommendation of local anesthetics (dentists and obstetricians), prenatal fluoride supplementation (obstetricians) and dental radiographs (dentists). The findings of this survey with dentists and obstetricians showed that dental management during pregnancy still presents some deviations from scientific literature recommendations, indicating the need to update these health care professionals in order to establish guidelines for prenatal dental care. PMID:19089217

  15. Changes in precipitation extremes in Brazil (Paraná River Basin)

    NASA Astrophysics Data System (ADS)

    Zandonadi, Leandro; Acquaotta, Fiorella; Fratianni, Simona; Zavattini, João Afonso

    2016-02-01

    This research was aimed at addressing aspects related to variation in the amount of precipitation during the period from 1986 to 2011 in the Paraná River Hydrographical Basin, Brazil, for 32 meteorological stations using 11 climate indices created by the ETCCDI (Expert Team, ET, on Climate Change Detection and Indices, ETCCDI). The daily rainfall data were organized in spreadsheets, which were subjected to an intense quality control and an accurate historical research. For each pluviometric index, we have estimated the trends and the statistical significant of the slopes have been calculated. The results confirm that an increase in total precipitation in almost all analyzed stations was registered, and the extreme precipitations were the main contributors to such additions. In fact, the significant increase in total annual rainfall in north-central sector of the basin are related to higher rates of heavy rain, mainly above 95th percentile, as well as to the highest event of rainfall above 10 mm. Instead the northern part of the region, showed declining trends of extreme rainfall, caused mainly by the reduction in the rainfall occurrences over 95th percentile. In order to evaluate the impact that the increasing extreme rainfall may cause in large urban centers, we have investigated the data of two municipalities (Curitiba, PR and Goiânia, GO-Brazil), where the positive trend can cause inconvenience to the population (floods and inundations) suggesting, at least, the need of implementation of more effective urban planning for the future.

  16. Profile of Heart Donors from the Human Valve Bank of the Santa Casa de Misericórdia de Curitiba

    PubMed Central

    Ferreira, Renata Maria; da Costa, Marise Teresinha Brenner Affonso; Canciglieri Junior, Osiris; Sant'Anna, Ângelo Márcio Oliveira

    2016-01-01

    Introduction Human heart valves are used as replacement valves and have satisfactory functional results compared with conventional prostheses. Objective Characterize the profile of effective heart donors from the human valve bank of the santa casa de misericórdia de curitiba and analyze the association between the profile variables. Methods It consists of a retrospective and quantitative study of electronic medical records from heart donors for heart valves. every heart donation made to the bank between january 2004 and december 2014 was studied. Results 2,149 donations were analyzed, from donors aged 0 to 71 years old, with an average of 34.9 ± 15.03 years old. most donors were male 65.7% (n=1,411) and 34.3% (n=738) were female. among the most frequent causes of the donors' death are trauma at 53% (n=1,139) and cerebral vascular accident at 34.2% (n=735). there was significant statistical association between the analyzed variables. Conclusion There has been an improvement in brazil's donation rate, being essential that the tissue banks work together with the state and federal district centers for notification, procurement and distribution of organs in order to increase the number of donors. PMID:27556322

  17. A review of antimalarial plants used in traditional medicine in communities in Portuguese-speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola.

    PubMed

    Silva, Jefferson Rocha de A; Ramos, Aline de S; Machado, Marta; de Moura, Dominique F; Neto, Zoraima; Canto-Cavalheiro, Marilene M; Figueiredo, Paula; do Rosário, Virgilio E; Amaral, Ana Claudia F; Lopes, Dinora

    2011-08-01

    The isolation of bioactive compounds from medicinal plants, based on traditional use or ethnomedical data, is a highly promising potential approach for identifying new and effective antimalarial drug candidates. The purpose of this review was to create a compilation of the phytochemical studies on medicinal plants used to treat malaria in traditional medicine from the Community of Portuguese-Speaking Countries (CPSC): Angola, Brazil, Cape Verde, Guinea-Bissau, Mozambique and São Tomé and Príncipe. In addition, this review aimed to show that there are several medicinal plants popularly used in these countries for which few scientific studies are available. The primary approach compared the antimalarial activity of native species used in each country with its extracts, fractions and isolated substances. In this context, data shown here could be a tool to help researchers from these regions establish a scientific and technical network on the subject for the CPSC where malaria is a public health problem.

  18. Brazil's urban laboratory takes the strain.

    PubMed

    Cavalcanti, C

    1996-01-01

    The city of Curitiba, in southern Brazil, has been known for its environmental-friendly urban planning. Its quality of life has encouraged the natural growth of the city, which has doubled its population to over 1.3 million in the last 20 years while retaining 52 m of green area per inhabitant. In this article, the city's efforts to retain its success in the face of a growing population are documented. An integrated transport system has been created, a main commercial street was turned into a pedestrian street, the building of the Wire Opera and the Free Environment University was created, and the decentralization of the country's health system, and the launching of a program of waste sorting. All these accomplishments subsequently generated tourism, bringing in an income of about 4% of the city's net income. In addition, they have helped the 300,000 inhabitants of the city's slums with their rubbish by selling them carts on a low installment price. Migratory flow has been curbed since the creation of the Return House, wherein social workers offer free tickets to potential migrants; and the Vila Rural (Rural Town), consisting of small rural properties where peasant farmers will be able to farm in between industrial jobs. In conclusion, if Curitiba's Institute of Urban Research and Planning team is successful in transposing to the State its achievements in the municipal administration, by the year 2000 Curitiba will have proved to be the seed of a revolution that will improve the development of the whole region. PMID:12295719

  19. Geophysical technique and groundwater monitoring to detect leachate contamination in the surrounding area of a landfill--Londrina (PR--Brazil).

    PubMed

    Lopes, Deize Dias; Silva, Sandra M C P; Fernandes, Fernandes; Teixeira, Raquel S; Celligoi, André; Dall'Antônia, Luiz Henrique

    2012-12-30

    The aim of the present study was to define leachate plume by using two techniques: geophysical and groundwater sampling in order to evaluate groundwater contamination. After performing a topographic survey and using geophysics, the leachate plume was identified. With this data, the wells for groundwater monitoring were located. Groundwater samples were analyzed for: COD, BOD, pH, alkalinity, conductivity, TKN and heavy metals. Through the electroresistivity method it was possible to define the shape of plume contamination. This method was important to locate the groundwater monitoring wells. The results of the physicochemical parameters showed the suitability of the geophysical study. The highest values of electric conductivity and alkalinity correspond to the wells located in the area interpreted as contaminated by leachate in the map of the resistivity. Even with seasonal variations, BOD values are low if compared to Brazilian environmental regulations, but COD values are higher up to 40 times the values of BOD. The concentrations of Ni, Zn, Cd and Cu in the groundwater are below the limits established by the potable water quality standards in Brazil, except for Pb whose concentration in groundwater were higher if compared to Brazilian legislation.

  20. Emergence of Acinetobacter baumannii international clone II in Brazil: reflection of a global expansion

    PubMed Central

    Martins, Natacha; Dalla-Costa, Libera; Uehara, Aline Almeida; Riley, Lee Woodland; Moreira, Beatriz Meurer

    2013-01-01

    The aim of this study was to investigate the occurrence of carbapenem-resistant Acinetobacter baumannii international clones (IC) in Curitiba, Brazil, using multilocus sequence typing and trilocus PCR-based typing schemes. IC2 was the first emerging clone. This IC was detected in an isolate from 2003 of a PFGE type spread in at least two hospitals since 1999. Subsequently, IC2 waned while IC1 and clonal complex 15/104 prevailed. This is the first description of IC2 in Brazil and Latin America. PMID:24121023

  1. Analysis of medicine advertisement produced in Brazil

    PubMed Central

    Wzorek, Lorilei de Fátima; Correr, Cassyano J.; Badaró Trindade, Angela C.; Pontarolo, Roberto

    Objective To analyze the compliance of drug advertisements with regulations in Brazil, subject to Resolution RDC No. 102/2000 since 2000, which abides by the WHO’s (World Health Organization) Ethical Criteria for Medicinal Drug Promotion, published in 1988. Methods Drug advertisements running within the period of October 2002 to October 2003 were collected and recorded. Media sources included various AM and FM radio stations, television channels, newspapers, and magazines, as well as printed material distributed in doctors’ offices, hospitals, drugstores, conferences, billboards, and bus doors. All sources were located in Curitiba City, Brazil, and its surrounding area. Advertisement content was analyzed according to a conformity checklist prepared based on the legal requirements of RDC No. 102/00. Results A total of 827 advertisements for 517 different products, 83.91% regularly registered as medicinal drugs and 16.09% unregistered products that should be registered according to the Brazilian regulations, were recorded and collected. Approximately 74.73% of the advertisements did not comply with regulations; on average, such advertisements had 4.6 infractions each. Conclusions The results of this research suggest that RDC No. 102/00 is not followed, which strengthens the need to adopt new forms of regulation to prohibit excesses of the pharmaceutical industry and to protect the population from abusive and misleading drug advertising. PMID:25214926

  2. Potential intake of intense sweeteners in Brazil.

    PubMed

    Toledo, M C; Ioshi, S H

    1995-01-01

    A survey of intense sweetener intakes was carried out in the winter of 1990 and summer of 1991 in Brazil. Data on the potential intake of the intense sweeteners aspartame, cyclamate and saccharin were generated, based on a representative sample of 673 individuals who completed a questionnaire designed to collect information on demographic details and habitual usage of sweetener-containing food and drinks. The respondents were randomly chosen among intense sweetener consumers living the cities of Campinas, São Paulo and Curitiba, Paraná. Potential daily intakes by individuals were calculated for each sweetener by combining each person's consumption of sweetener-containing food and beverages with information generated by the determination of the concentrations of the sweeteners used in these products. The data showed that 72% of the studied population consumed saccharin, 67% cyclamate and 40% aspartame. The main reasons alleged for the use of intense sweeteners were weight-control diet (36%), diabetes (35%) and weight loss (23%). Table-top sweeteners were the major source of sweeteners, followed by soft drinks. The median daily intake of aspartame, cyclamate and saccharin represented approximately 2.9, 15.5, and 16-4% of the corresponding ADI, respectively. Diabetics in general had a much higher intake within the studied population.

  3. Spotlight: Brazil.

    PubMed

    Carter, M

    1996-08-01

    Brazil is South America's largest country and home to nearly half of the continent's people. Despite solid economic growth, Brazil has one of the world's widest income disparities. In the early 1990s, nearly 40% of urban and 66% of rural Brazilians lived in poverty. The streets of Brazil's cities are home to a large population of street children. Although it is difficult to estimate, 10 million children and youths may be either homeless or making a meager living off of the streets. Street children may be linked to prostitution and drugs and be the targets or perpetrators of violence. Child labor is an issue in Brazil. Today an estimated 30% of rural children and 9% of urban children ages 10-13 work in the formal economy. In some rural areas, 60% of workers are ages 5-17. Child labor also contributes to Brazil's relatively low educational attainment levels. UNICEF estimates that around 1990 only 1/3 of all Brazilian children continued on to secondary school, compared to 74% and 47%, respectively, for the Latin America and Caribbean regions. Immunization rates among Brazil's children are rising but still lag slightly behind regional averages. The mortality rate for children under age 5 decreased dramatically from 181 deaths for every 1000 live births in 1960 to 61/1000 in 1994. During the same time period, the average number of children born to a woman during her lifetime dropped from 6.2 to 2.8. This fertility decline is related in part to increased access to and acceptance of family planning. Contraceptive prevalence, including traditional and modern methods, is around 66%, with female sterilization and the pill being the most popular methods. Brazil's abortion rates are high, despite laws limiting access to abortion services. One estimate suggests that about 30% of all pregnancies are terminated through abortion each year.

  4. Public–private partnerships in solid waste management: sustainable development strategies for Brazil.

    PubMed

    Kruljac, Shani

    2012-01-01

    An often overlooked issue in the discussion of sustainable development is that of municipal solid waste management. Yet solid waste management is pervasive in all sustainable development objectives: its management, or lack thereof, can have major implications for the health of the environment, economy and society. This article argues the need for a governance dimension in the sustainability model, taking into account implementation strategies, monitoring and institutional controls. This focus heavily relies on integrated public–private partnerships and deliberative democracy approaches in order to achieve sustainability within the solid waste management sector. In this article, national and local policies in Brazil are analysed, primarily focusing on the inclusion of informal waste collection into municipal solid waste management schemes. The city of Curitiba, in the state of Paraná, which is world-renowned for its innovative sustainable development policies, is used to frame and illustrate the case.

  5. Detection of thermophilic Campylobacter sp. in raw chicken sausages by methods ISO 10272: 2006 in Curitiba – Parana State – Brazil

    PubMed Central

    Konell, K.; Gelinsk, M.A.; Benetti, T.M.; Abrahão, W.M.

    2014-01-01

    The aim of this study was the detection of Campylobacter sp. in raw chicken sausages using the methods ISO 10272-1 and ISO 10272-2. The overall prevalence of Campylobacter sp. in the samples tested was 16.67%, representing a serious risk to the health of consumers, particularly if measures guaranteeing proper cooking of foods and prevention of cross-contamination are not adopted. Furthermore, the majority of campylobacteriosis cases in humans are caused by consumption or improper handling of contaminated raw or undercooked poultry meat, which constitute the main vehicle of this infection. PMID:25763066

  6. PR-PR: cross-platform laboratory automation system.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms. PMID:25126893

  7. PR-PR: Cross-Platform Laboratory Automation System

    SciTech Connect

    Linshiz, G; Stawski, N; Goyal, G; Bi, CH; Poust, S; Sharma, M; Mutalik, V; Keasling, JD; Hillson, NJ

    2014-08-01

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  8. PR-PR: cross-platform laboratory automation system.

    PubMed

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  9. Central Brazil

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This Moderate resolution Imaging Spectroradiometer (MODIS) true-color image was acquired on October 19, 2000, over a region in Brazil large enough to show much of the country's diverse landscape. Spanning some 8.5 million square kilometers (3.2 million square miles), Brazil is by far the largest South American nation--both in terms of land and population. The region known as the Amazon Basin lies to the northwest (upper left) and extends well beyond the northern and western edges of this scene. Typically, from this perspective Amazonia appears as a lush, dark green carpet due to the thick canopy of vegetation growing there. Some of the Amazon Basin is visible in this image, but much is obscured by clouds (bright white pixels), as is the Amazon River. This region is home to countless plant and animal species and some 150,000 native South Americans. The clusters of square and rectangular patterns toward the center of the image (light green or reddish-brown pixels) are where people have cleared away trees and vegetation to make room for development and agriculture. Toward the western side of the scene there is considerable haze and smoke from widespread biomass burning in parts of Brazil and Bolivia, which shares its eastern border with Brazil. Toward the east in this image is the highland, or 'cerrado,' region, which is more sparsely vegetated and has a somewhat drier climate than the Amazon Basin. The capital city, Brasilia, lies within this region just southwest of the Geral de Goias Mountains (orangish pixels running north-south). There are two large water reservoirs visible in this scene--the Sobradinho Reservoir about 800 km (500 miles) northeast of Brasilia, and the Paranaiba about 500 km (300 miles) southwest of Brasilia. MODIS flies aboard NASA's Terra spacecraft. Image courtesy Brian Montgomery, Reto Stockli, and Robert Simmon, based on data from the MODIS Science Team.

  10. Radiation of powdered milk produced at Londrina, PR, Brazil

    NASA Astrophysics Data System (ADS)

    Melquiades, F. L.; Appoloni, C. R.

    2001-06-01

    This work deals with the measurement of radioactive activities in powdered milk, with high resolution gamma-ray spectrometry, using a HPGe detector. Preliminary measurements were accomplished to define the kind of the system shield, the geometry of the sample recipient, the size of the sampling and the self absorption correction. It was possible to measure the radionuclides 40K, 137Cs and 208Tl. Tukey's average comparison test was used to check the repeatability of the measurements.

  11. Préface

    NASA Astrophysics Data System (ADS)

    Chardonnet, Christian; Millot, Guy

    2006-10-01

    COLOQ, réunion nationale biennale initiée en 1988 par la communauté française des lasers, de l'optique non linéaire et de l'optique quantique atteint sa neuvième édition. Depuis sa création, les objectifs poursuivis sont les suivants : - réunir la communauté française des lasers, de l'optique non linéaire et de l'optique quantique, en dépassant les clivages fondamental/appliqué, recherche publique/industrielle, - faire le point sur les avancées récentes, - permettre aux jeunes chercheurs de se rencontrer, de s'exprimer et de s'aguerrir au plan national. Le but est que tout thésard du domaine de l'optique puisse participer à COLOQ une fois durant sa thèse, présenter son travail et de se confronter à la communauté de l'optique. COLOQ9 s'est tenu, pour sa 9e édition, sur le campus universitaire de Dijon, du 7 au 9 septembre 2005. Il a été une grande réussite : nombre de participants (255) et de présentations scientifiques record (148 affiches), forte représentation des industriels (15) et participation d'environ 200 lycéens aux conférences grand public. Le nombre plus élevé que prévu d'affiches a rendu un peu serrée leur présentation : une attention particulière sera portée à cet aspect lors des prochaines éditions. Ces journées ont été consacrées à des conférences invitées données par des scientifiques de haut niveau et à des présentations sous forme d'affiches. Une plage de temps importante a été réservée pour des discussions autour des affiches. À proximité immédiate de la salle de conférence, l'exposition de matériels spécialisés pour les lasers, l'optique et l'optoélectronique a été une occasion pour les jeunes participants de découvrir et contacter les industriels et les autres grands acteurs de l'optique. L'année 2005 ayant été l'année mondiale de la physique, COLOQ9 a retenu comme thème central ”1905-2005 : à propos d'Einstein". Plusieurs grandes conférences ont été dédiées à ce th

  12. Military Education in Brazil

    ERIC Educational Resources Information Center

    Haussman, Fay

    1974-01-01

    A large share of the credit for Brazil's recent progress must go to Brazil's highly structured military education, including the colegios militares (high schools), the military colleges, and the general staff schools. (Author/PG)

  13. Biochemical Education in Brazil.

    ERIC Educational Resources Information Center

    Vella, F.

    1988-01-01

    Described are discussions held concerning the problems of biochemical education in Brazil at a meeting of the Sociedade Brazileira de Bioquimica in April 1988. Also discussed are other visits that were made to universities in Brazil. Three major recommendations to improve the state of biochemistry education in Brazil are presented. (CW)

  14. Préface

    NASA Astrophysics Data System (ADS)

    Mazière, D.

    2002-04-01

    Faisant suite aux deux précédents colloques "Matériaux pour les machines thermiques" et "Matériaux pour le nucléaire" , le colloque 2001 de l'INSTN intitulé "Matériaux pour les énergies propres" s'est focalisé sur les problèmes de matériaux encore à résoudre dans ce secteur industriel. Le colloque de métallurgie est traditionnellement organisé par des ense ignants du DEA Métallurgie et Matériaux et un comité scientifique choisi chaq ue année en liaison avec le thème traité. Les étudiants de ce DEA, qui est hab ilité entre Paris XI, Paris VI, l'Ecole des Mines de Paris, l'Ecole Centrale de Pari s et l'INSTN, sont invités à participer à ce colloque et aux débats scientifiques qui s'y déroulent. Des conférences invitées à caractère péda gogique permettent d'introduire les différents thèmes abordés qui sont ensuite développés dans des présentations plus novatrices. Cette manifestation a pour ambition de favoriser la rencontre de scientifiques d'horizons divers venant de milieux académiques ou industriels entre eux et avec les étudiants et thésards. Cette 44e édition, dont les comptes rendus sont publiés ici, a fait le point sur les problèmes de matériaux rencontrés lors de la production, du stockage et de la conversion des énergies dites propres en englobant lesprogrès constants des industriels de l'automobile. Ce colloque a réuni, du 26 au 28 juin 2001, 63 participants provenant d'universités ou grandes écoles (18), du CEA (17), du CNRS (10) et de l'industrie ou de centres de recherche associés. L'ensemble des problèmes de matériaux de ce secteur ont été examinés au cours des six sessions ci-dessous : dépollution des gaz d'échappement ; combustion catalytique en production thermique ; nouvelles batteries ; piles à combustibles ; production et stockage d'hydrogène ; production et stockage d'énergie solaire. Vingt huit communications dont vingt deux orales ont illustré les dével oppements en cours. Dix

  15. Manaus, Brazil

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The junctions of the Amazon and the Rio Negro Rivers at Manaus, Brazil. The Rio Negro flows 2300 km from Columbia, and is the dark current forming the north side of the river. It gets its color from the high tannin content in the water. The Amazon is sediment laden, appearing brown in this simulated natural color image. Manaus is the capital of Amazonas state, and has a population in excess of one million. The ASTER image covers an area of 60 x 45 km. This image was acquired on July 16, 2000 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image Earth for the next 6 years to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, California, is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long-term research and technology program designed to examine Earth's land, oceans, atmosphere, ice and life as a total integrated system.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation

  16. Préface

    NASA Astrophysics Data System (ADS)

    Aspect, Alain

    2004-11-01

    COLOQ est une conférence regroupant, tous les deux ans, la communauté scientifique et industrielle nationale travaillant dans les domaines des lasers, de l'optique non-linéaire et de l'optique quantique. Elle s'est tenue pour sa huitième édition à Toulouse, du 3 au 5 septembre 2004, sur le campus de I'INSA. Comme il est de tradition tous les quatre ans, COLOQ était couplé avec Horizons de l'optique, avec en particulier une journée commune dont le programme avait été préparé en concertation par les deux comités scientifiques. Depuis sa création, COLOQ a pour but de favoriser les rencontres entre les chercheurs des différents laboratoires nationaux publics ou privés travaillant sur les lasers et l'optique quantique au sens large. C'est un moyen privilégié de resserrer les liens de cette communauté et d'y intégrer les jeunes chercheurs. Ces derniers y trouvent l'occasion de se connaître, de se faire connaître, de découvrir la communauté à laquelle ils appartiennent et d'élargir leurs connaissances des thèmes qui la structurent. La participation de 230 chercheurs et d'une vingtaine d'exposants de matériels spécialisés dans les lasers et l'optoélectronique témoigne de la vitalité de COLOQ et de son audience dans les laboratoires et chez les industriels de l'optique. Le programme de COLOQ 8 comportait d'une vingtaine de conférences générales données par des chercheurs de renom international, et des séances de communications par affiches, occasions privilégiées de rencontres et d'échanges. Les exposés ont porté sur des sujets particulièrement actifs au niveau national et international, avec un accent sur des thèmes importants pour la région toulousaine : contrôle cohérent, optique et nanosciences, optique et astronomie, sans oublier la traditionnelle rubrique phénomènes fondamentaux, éclectique pour ne pas dire hétéroclite, mais si représentative d'une des ambitions de COLOQ qui est d'offrir à ses participants une

  17. [Physical disability and hospitalization in São Paulo, Brazil].

    PubMed

    Castro, Shamyr Sulyvan; Carandina, Luana; Barros, Marilisa Berti de Azevedo; Goldbaum, Moisés; Cesar, Chester Luiz Galvão

    2013-05-01

    This study aimed to verify the association between physical disability and hospitalization in São Paulo, Brazil, based on a health survey conducted in 2008. The study used a probabilistic stratified sampling process (sex/age) with two-stage clustering (census tracts and households). Data were collected through structured interviews including thematic 21 sections, using mostly multiple-choice questions. The analysis used crude and adjusted prevalence ratios (PR) and 95% confidence intervals (95%CI) with Poisson regression. The survey module of Stata 9.2 was used, with significance set at 5%. A total of 2,690 persons were interviewed, with a mean age of 38.75 years (95%CI: 37.54-39.96). Hospitalization was associated with disability (hearing, PR = 1.59; physical, PR = 3.77; multiple PR = 3.26). People with disabilities (hearing, physical - paralysis/amputation, and multiple) reported more hospitalizations than those without disabilities.

  18. Préface

    NASA Astrophysics Data System (ADS)

    Ouerdane, Youcef; Laporte, Pierre

    2005-06-01

    L'objectif de la série de colloques UVX est de réunir, au rythme d'une fois tous les deux ans, les scientifiques et industriels travaillant dans le domaine du développement des sources de photon de grande énergie (UV, VUV, et X) et de leurs applications. En particulier cette manifestation est l'occasion de faire se rencontrer une communauté très pluridisciplinaire (physique, chimie, biologie, sciences de l'univers) liée à des domaines en forte évolution technologique (lasers et rayonnement synchrotron notamment). Le colloque UVX 2004 s'est tenu au Palais des Congrès de Saint-Étienne (42000) du 7 au 11 juin 2004. La période écoulée depuis l'édition précédente (Oléron 2002) a été particulièrement active dans tous les domaines concernés : grands projets de sources, méthodes de diagnostic au sens large. Une nouvelle fois on constate que le bref et l'ultra-bref ont une place privilégiée, qu'il s'agisse du travail sur les accélérateurs ou sur les lasers qui, bien sûr, dans la course aux temps courts remportent la palme avec la présence de spécialistes du domaine attoseconde. La communauté représentée a la chance d'être en prise directe avec de très grands projets en phase active de réalisation comme le Laser Megajoule (LMJ), la source SOLEIL, et un projet d'ampleur plus modeste mais remarquable dans son domaine : la source LASERIX d'Orsay/Palaiseau. On pourra citer aussi le projet Arc en Ciel qui, lui, est encore au stade de sa définition. - SOLEIL, source de nouvelle génération de rayonnement synchrotron (plateau de Saclay) est dans une phase active de réalisation : achèvement de l'infrastructure en 2005 et injection du 1o faisceau dans l'anneau de stockage prévu également en 2005. Cette source devrait être la meilleure au monde dans le domaine VUV/X mous, tout en restant très polyvalente (brillance, accordabilité, structure temporelle, polarisation) et complémentaire de l'ESRF. Au final on disposera de 21 lignes de lumi

  19. ESO PR Highlights in 2006

    NASA Astrophysics Data System (ADS)

    2007-01-01

    Last year proved to be another exceptional year for the European organisation for ground-based astronomy. ESO should begin the New Year with two new member states: Spain (PR 05/06) and the Czech Republic (PR 52/06). ESO PR Highlights 2006 2006 was a year of renovation and revolution in the world of planets. A new Earth-like exoplanet has been discovered (PR 03/06) using a network of telescopes from all over the world (including the Danish 1.54-m one at ESO La Silla). It is not the only child of this fruitful year: thanks to the combined use of ESO's Very Large Telescope (VLT) and La Silla instruments, a surprising system of twin giant exoplanets was found (PR 29/06), and a trio of Neptune-like planets hosted by a nearby star were identified (PR 18/06). These results open new perspectives on the search for habitable zones and on the understanding of the mechanism of planet formation. The VISIR instrument on the VLT has been providing unique information to answer this last question, by supplying a high resolution view of a planet-forming disc (PR 36/06). There are not only new members in the planets' register: during the General Assembly of the International Astronomical Union held in Prague (Czech Republic), it was decided that Pluto is not a planet anymore but a 'dwarf planet'. Whatever its status, Pluto still has a satellite, Charon, whose radius and density have been measured more accurately by observing a rare occultation from different sites, including Cerro Paranal (PR 02/06). The scientific community dedicated 2006 to the great physicist James Clerk Maxwell (it was the 175th anniversary of the birth): without his electromagnetic theory of light, none of the astonishing discoveries of modern physics could have been achieved. Nowadays we can look at distant galaxies in great detail: the GIRAFFE spectrograph on the VLT revealed that galaxies 6 billion years ago had the same amount of dark matter relative to stars than nowadays (PR 10/06), while SINFONI gave an

  20. Préface

    NASA Astrophysics Data System (ADS)

    Rozelot, J.-P.; Bijaoui, A.

    2002-03-01

    Ce livre reprend pour l'essentiel des cours qui ont été dispensées lors de deux Écoles thématiques réalisées avec le concours du CNRS. La première fait partie du cycle des Écoles d'Astrophysique Solaire d'Oléron (F), dont le succès est grandissant dans la communauté concernée. La seconde s'est tenue spécifiquement à La Grande Motte près de Montpellier (F). L'objectif de ces Écoles, qui se sont tenues à une année d'intervalle, était de donner aux chercheurs concernés, qu'ils soient du secteur des Sciences de l'Univers ou de celui des Sciences pour l'Ingénieur, une formation aux nouvelles méthodes d'analyses de données, afin de leur faire bien comprendre l'intérêt de ces nouveaux outils pour la résolution de leurs problèmes scientifiques. En effet, les chercheurs disposent d'une quantité de plus en plus grande d'informations obtenues grâce aux très nombreux observatoires spatiaux et au sol. Pour l'analyse de ces données, des logiciels complexes ont été mis au point et distribués dans les laboratoires. Grâce au réseau, chacun peut extraire d'une banque de données les signaux ou les images observées, les réduire avec des programmes disposant d'une documentation élaborée et obtenir des résultats scientifiques pertinents. Mais les chercheurs sont souvent limités dans leurs connaissances pour aborder les problèmes d'analyse des données, et ils sont perplexes devant le choix de l'algorithme a utiliser. L'analyse des données est une discipline vaste, ayant justement pour tâche de permettre l'extraction des informations pertinentes des observations. La formation à ces méthodes contemporaines, formation qui a été proposée et est relatée dans ce livre, permet à chacun de mieux concevoir sa stratégie d'analyse pour pouvoir ainsi choisir les programmes de manière judicieuse. Cet ouvrage, novateur, se veut d'offrir de nouvelles idées et d'ouvrir de nouvelles voies. Il est divisé en trois grandes parties qui permettent au

  1. Pre-exposure prophylaxis for men and transgender women who have sex with men in Brazil: opportunities and challenges

    PubMed Central

    Veloso, Valdilea G; Mesquita, Fabio; Grinsztejn, Beatriz

    2015-01-01

    Introduction The World Health Organization recently released guidelines on the use of pre-exposure prophylaxis (PrEP) for prevention of HIV infection among men and transgender women (TGW) who have sex with men based on results of randomized clinical trials. The aim of this commentary is to discuss the opportunities and challenges of incorporating PrEP into the Brazilian continuum of HIV care and prevention for men who have sex with men (MSM) and TGW. Discussion Key aspects of the AIDS epidemic among MSM and TGW in Brazil and the comprehensive Brazilian response to the epidemic are presented. The universal access to health care provided through the Brazilian Unified Health System (SUS) and the range of prevention and care services already available countrywide to HIV-positive individuals and at-risk MSM and TGW are identified as the main facilitators for the implementation of PrEP. Limited PrEP awareness among MSM, TGW and health care providers, low HIV testing frequency and low HIV risk perception among MSM and TGW represent the core challenges to be addressed. Data generated by demonstration projects in Brazil will provide an important contribution to PrEP rollout in Brazil. Conclusions The implementation of PrEP in Brazil is feasible. A synergistic rollout of treatment as prevention and PrEP will maximize public health and individual benefits of the country's comprehensive response to the AIDS epidemic. PMID:26198347

  2. Préface

    NASA Astrophysics Data System (ADS)

    Jörgen Stevefelt, Henri Bachau Et

    2003-06-01

    UVX 2002, sixième édition du “Colloque sur les Sources Cohérentes et Incohérentes UV, VUV, et X : Applications et Développements Récents" s'est tenu du 11 au 14 juin 2002 au Centre CAES du CNRS “La Vieille, Perrotine", à Saint-Pierre d'Oléron. Le colloque a réunni une centaine de chercheurs et d'industriels et a permis de faire le point sur la production, la caractérisation et l'utilisation de rayonnement dans un domaine spectral s'étendant de l'ultraviolet aux rayons X. Les participants ont pu assister a trente conférences et une table ronde autour des problèmes locaux de pollution, une cinquantaine d'affiches ont été présentées au travers de deux sessions. Une douzaine d'industriels ont exposé leurs produits durant les séances d'affiches.Conformément aux éditions précédentes, les domaines couverts par le colloque UVX 2002 sont très variés et il est impossible de les résumer en quelques lignes. Parmi les activités en développement rapide on notera les lasers femtosecondes dont les applications se multiplient dans les laboratoires (propriétés des molécules, agrégats et solides), dans l'industrie (usinage, ablation...) et en médecine. L'absence de thermalisation ou de diffusion thermique ouvre aussi des perspectives pour la réalisation de films minces par ablation laser, un domaine où les lasers excimères sont traditionnellement utilisés, avec des applications importantes dans le secteur des télécommunications. Dans le domaine de l'extrème UV, des progrès significatifs ont été réalisés par plusieurs groupes dans la gamme de longueur d'onde de 5 à 20 nm, ouvrant ainsi la voie au développement industriel de la lithographie EUV. On note les progrès dans la réalisation des sources UV et X (laser X, génération d'harmoniques, laser a électrons libres) et la nécessité de développer des optiques adaptées. Une perspective intéressante, ouverte par la génération d'harmoniques, est la production d

  3. Leprosy in a University Hospital in Southern Brazil*

    PubMed Central

    de Lima, Adma Silva; Pinto, Karin Cristine; Bona, Míryan Priscilla Santos; de Mattos, Suelen Mayara Lopes; Hoffmann, Marina Portiolli; Mulinari-Brenner, Fabiane Andrade; Ottoboni, Vanessa Cristhine Dallolmo

    2015-01-01

    BACKGROUND Leprosy is an infectious disease that may lead to irreversible nerve damage, compromising patient's quality of life and leading to loss of working years. OBJECTIVES To evaluate the epidemiological profile of patients followed at a University Hospital. MATERIALS AND METHODS This is a retrospective observational study, based on a review of medical records. We studied the clinical and epidemiological features of patients with leprosy monitored at the Hospital de Clínicas of the Federal University of Paraná between January 2005 and January 2010. RESULTS The mean age was 47.51, while 35.94% of patients were aged 41-60. The male:female rate was 1.8:1. The most prevalent occupations were: retired, students or rural workers. Patients came mainly from Curitiba or nearby areas, but there were also patients from the countryside. The mean diagnostic delay was 24.57 months. Multibacillary forms prevailed, with the lepromatous variety being the most common, closely followed by the borderline type. Neural enlargement was found in more than 50% of the patients and 48.44% of them developed reactional states. Hemolysis was the most commonly detected drug side effect. Initial functional evaluation was possible in 70% of patients, 55% of whom had disabilities upon diagnosis. The most prevalent associated disease was hypertension. CONCLUSIONS This study showed an important diagnostic delay and a high rate of sequelae in this specific population. Brazil is one of the few remaining countries that has not yet eradicated leprosy and it is important to improve health policies in order to prevent sequelae and achieve eradication. PMID:26560210

  4. Préface

    NASA Astrophysics Data System (ADS)

    Paulus, Werner; Meinnel, Jean

    2003-02-01

    de vue européen, si les sources de l'ILL et d'ISIS peuvent encore être considérées comme des leaders au point de vue mondial, il est évidemment souhaitable que la nouvelle source neutronique à spallation (European Spallation Source : ESS) soit rapidement réalisée. Aujourd'hui ce projet est bien avancé, cette source devrait dépasser le flux des sources actuelles par près de deux ordres de grandeur et ainsi de maintenir au meilleur niveau les compétences Européennes. Il est évident qu'une utilisation efficace et intelligente des sources existantes, mais aussi de celles de la nouvelle génération, implique une certaine infrastructure nationale tant au niveau de la conception, de la réalisation que du fonctionnement des différents spectromètres. Ceci implique un très fort engagement des universités dans les différents projets de recherche. Le devoir des universités qui en résulte est donc d'intégrer l'utilisation des “grands instruments" dans leur programme d'enseignement. Dans ce sens, nous souhaitons que ce cours, entièrement rédigé en français, contribue à la fois à aider les chercheurs “non spécialistes” à accéder plus facilement au domaine neutronique, mais aussi à servir de base aux enseignants pour l'organisation et la préparation de leurs cours.Nous tenons à remercier tous les collègues qui ont accepté de rédiger de façon détaillée les cours qu'ils avaient présentés oralement dans la grande salle du VVF de Trégastel, ainsi que toutes les personnes qui ont contribué à la réussite du séjour ou à la réalisation de ce fascicule. Nous gardons un excellent souvenir de l'atmosphère de l'École qui a eu lieu à Trégastel, en plein centre de la côte de granite rose en Bretagne, en mai 2001 et était jumelée avec les Journées de la diffusion neutronique, elles aussi organisées sous l'égide de la SFN.Nous souhaitons que la lecture de cet ouvrage soit utile à un maximum de chercheurs.

  5. Préface

    NASA Astrophysics Data System (ADS)

    Moncorgé, R.

    2006-12-01

    Cette nouvelle édition du Colloque UVX avait pour objectifs de : - réunir les chercheurs et les industriels intéressés par les applications et les développements les plus récents obtenus sur les sources UV, VUV et X, cohérentes ou incohérentes, et les optiques et matériaux associés ; - dresser un bilan des sources de photons à haute énergie et de leurs applications courantes et futures ; - susciter de nouvelles collaborations ; - ouvrir de nouveaux champs disciplinaires. Elle a été organisée par le laboratoire CIRIL au VVF de Colleville-sur-Mer, dans le département du Calvados, du 6 au 9 juin 2006, la journée du 5 juin ayant été consacrée à une réunion de travail du GDR CNRS SAXO, ce GDR regroupant une majorité de scientifiques concernés par le Colloque UVX. La manifestation a réuni ainsi une centaine de participants dont une dizaine d'exposants industriels. Parmi ces participants, trente étaient invités à donner une conférence orale. Une sélection a été faite également parmi les meilleures communications soumises par affiches pour qu'elles soient présentées oralement. Une trentaine de ces communications ont été préparées sous la forme d'articles de 6 à 12 pages et font l'objet de cet ouvrage. De nombreux travaux récents ont été exposés tant au niveau des sources que des techniques de caractérisation et des applications, ceci dans des domaines très divers allant de la physique des lasers et de la mise en forme spatiale et temporelle des faisceaux au domaine de l'imagerie médicale et biologiques en passant par les techniques de fabrication des cristaux, fibres et films minces organiques et inorganiques. Plusieurs résultats marquants en sont ressortis. Dans le domaine des sources, la mise en forme spatiale du faisceau laser utilisé pour la production d'harmoniques d'ordre élevé dans les gaz, ceci à l'aide de lames de phase peu onéreuses et simples d'utilisation, semble être une bonne solution pour accroître les

  6. Occurrence of Neuroblastoma among TP53 p.R337H Carriers

    PubMed Central

    Mastellaro, Maria José; Cardinalli, Izilda Aparecida; Zambaldi, Lilian Girotto; Aguiar, Simone Santos; Yunes, José Andrés

    2015-01-01

    The high incidence of adrenocortical tumors and choroid plexus carcinoma in children from South and Southeastern regions of Brazil is associated with the germline p.R337H mutation of TP53 gene. The concomitant occurrence of neuroblastoma and adrenocortical tumors in pediatric patients harboring the p.R337H mutation at our institution prompted us to investigate the putative association between p.R337H and pediatric neuroblastoma. Genomic DNA samples from 83 neuroblastoma patients referred to a single institution during the period of 2000–2014 were screened for the p.R337H mutation. Available samples from carriers were investigated for both nuclear p53 accumulation and loss of heterozigosity in tumor. Clinical data were obtained from medical records in order to assess the impact of 337H allele on manifestation of the disease. Seven out 83 neuroblastoma patients (8.4%) were carriers of the TP53 p.R337H mutation in our cohort. Immunohistochemical analysis of p.R337H-positive tumors revealed nuclear p53 accumulation. Loss of heterozigosity was not found among available samples. The presence of 337H allele was associated with increased proportion of stage I tumors. Our data indicate that in addition to adrenocortical tumors, choroid plexus carcinoma, breast cancer and osteosarcoma, genetic counseling and clinical surveillance should consider neuroblastoma as a potential neoplasia affecting p.R337H carriers. PMID:26452166

  7. ESO PR Highlights in 2005

    NASA Astrophysics Data System (ADS)

    2006-01-01

    2005 was the year of Physics. It was thus also in part the year of astronomy and this is clearly illustrated by the numerous breakthroughs that were achieved, in particular using ESO's telescopes. One of the highlights was without any doubt the confirmation of the first image of an exoplanet , around the star 2M1207 (see ESO PR 12/05). ESO's telescopes also found a Neptune-mass exoplanet around a small star ( PR 30/05) - a discovery that proves crucial in the census of other planetary systems, and imaged a tiny companion in the close vicinity of the star GQ Lupi, a very young object still surrounded by a disc, with an age between 100,000 and 2 million years ( PR 09/05). Moreover, using a new high-contrast adaptive optics camera on the VLT, the NACO Simultaneous Differential Imager, or NACO SDI, astronomers were able for the first time to image a companion 120 times fainter than its star , very near the star AB Doradus A. This companion appears to be almost twice as heavy as theory predicts it to be ( PR 02/05). ESO's telescopes proved very useful in helping to solve a 30-year old puzzle . Astronomers have for the first time observed the visible light from a short gamma-ray burst (GRB). Using the 1.5m Danish telescope at La Silla (Chile), they showed that these short, intense bursts of gamma-ray emission most likely originate from the violent collision of two merging neutron stars ( PR 26/05). Additional evidence came from witnessing another event with the VLT ( PR 32/05). Also in this field, astronomers found the farthest known gamma-ray burst with ESO's VLT, observing an object with a redshift 6.3, i.e. that is seen when the Universe was less than 900 million years old ( PR 22/05). On July 4, NASA's Deep Impact spacecraft plunged onto Comet 9P/Tempel 1 with the aim to create a crater and expose pristine material from beneath the surface. For two days before and six days after, all major ESO telescopes have been observing the comet, in a coordinated fashion and in

  8. Directives préalables

    PubMed Central

    O’Sullivan, Rory; Mailo, Kevin; Angeles, Ricardo; Agarwal, Gina

    2015-01-01

    Résumé Objectif Établir la prévalence de patients dotés de directives préalables dans une pratique familiale et décrire les points de vue des patients quant au rôle du médecin de famille dans l’amorce de discussions à propos des directives préalables. Conception Un questionnaire auquel les patients ont répondu eux-mêmes. Contexte Une clinique d’enseignement en médecine familiale achalandée en milieu urbain, à Hamilton, en Ontario. Participants Un échantillon de commodité formé de patients adultes qui se sont présentés à la clinique durant une semaine de travail typique. Principaux paramètres à l’étude La prévalence des directives préalables dans une population de patients a été déterminée et les attentes à l’endroit du rôle de leur médecin de famille ont été sollicitées. Résultats Les répondants au sondage étaient au nombre de 800 (un taux de réponse de 72,5 %) et leurs groupes d’âges étaient bien répartis; 19,7 % d’entre eux avaient rédigé des directives préalables et 43,8 % avaient déjà discuté du sujet des directives préalables, mais seulement 4,3 % de ces discussions avaient eu lieu avec un médecin de famille. Dans 5,7 % des cas, un médecin de famille avait soulevé la question; 72,3 % des répondants croyaient que les patients devraient amorcer la discussion. Les patients qui considéraient les directives préalables d’une importance extrême étaient considérablement plus enclins à vouloir que leur médecin de famille commence la conversation (rapport de cotes de 3,98; p < ,05). Conclusion Les directives préalables n’étaient pas systématiquement abordées dans la pratique familiale. La plupart des patients préféraient amorcer la discussion des directives préalables. Toutefois, les patients qui considéraient le sujet d’une extrême importance voulaient que leur médecin de famille commence la discussion.

  9. Population structure of Rudgea parquioides, a shade-tolerant shrub species, in Southern Brazil.

    PubMed

    Cardoso, Fernanda C G; Salvalaggio, Ana P B; Marques, Márcia C M

    2010-09-01

    The expectations that shade-tolerant forest species show 1) a population structure composed by a high amount of small individuals, and 2) biomass allocation for diameter higher than for height growth, were tested for Rudgea parquioides, a typical shrub in Southern Brazil. We described the size structure (height and stem diameter) and allometrical relations of a R. parquioides population by counting and measuring all the individuals in a 725m(2) area in the municipality of Curitiba (25°25'S; 49°19'W). A total of 916 individuals (12,634 ind.ha(-1)) were recorded in the area. The first expectation was supported, since distribution by height and diameter classes showed a predominance of small individuals (skewness coefficients > 1). On the other hand, the regression between height and stem base diameter showed slope β < 1, which indicates that growth in height is higher than in diameter, not supporting the second expectation. These results show that life strategies in shade-tolerant species may imply in more trade-off combinations than previously described.

  10. Uranium deposits of Brazil

    SciTech Connect

    1991-09-01

    Brazil is a country of vast natural resources, including numerous uranium deposits. In support of the country`s nuclear power program, Brazil has developed the most active uranium industry in South America. Brazil has one operating reactor (Angra 1, a 626-MWe PWR), and two under construction. The country`s economic challenges have slowed the progress of its nuclear program. At present, the Pocos de Caldas district is the only active uranium production. In 1990, the Cercado open-pit mine produced approximately 45 metric tons (MT) U{sub 3}O{sub 8} (100 thousand pounds). Brazil`s state-owned uranium production and processing company, Uranio do Brasil, announced it has decided to begin shifting its production from the high-cost and nearly depleted deposits at Pocos de Caldas, to lower-cost reserves at Lagoa Real. Production at Lagoa Real is schedules to begin by 1993. In addition to these two districts, Brazil has many other known uranium deposits, and as a whole, it is estimated that Brazil has over 275,000 MT U{sub 3}O{sub 8} (600 million pounds U{sub 3}O{sub 8}) in reserves.

  11. Chronic low back pain among tobacco farmers in southern Brazil

    PubMed Central

    Meucci, Rodrigo D; Fassa, Anaclaudia G; Faria, Neice M X; Fiori, Nadia S

    2015-01-01

    Background: Despite tobacco farming involving intensive manual labor, chronic low back pain (CLBP) prevalence and associated factors are unknown among this occupational group. Methods: This was a cross-sectional study conducted in southern Brazil. A random sample of tobacco farmers was interviewed. Socioeconomic and individual characteristics, occupational tasks, workloads, and comorbidities were investigated. Chronic low back pain prevalence was described in relation to independent variables, and associations were examined with Poisson regression. Results: Chronic low back pain prevalence was 8·4%. Increasing age, rearing two or more species of livestock (PR 1·65), exposure to tasks that require heavy physical exertion (PR 2·00), working in awkward postures (PR 1·36), green tobacco sickness (GTS) (PR 1·63), pesticide poisoning (PR 2·37), and minor psychiatric disorders (PR 2·55) were associated with CLBP. Conclusions: This study found that CLBP is a relevant health problem among tobacco farmers and highlights understudied risk factors such as pesticide poisoning and GTS. Policies to minimize exposure to physiological and chemical workloads in tobacco planting to prevent CLBP are needed. Health professionals should be trained to diagnose and prevent acute low back pain episodes and thus prevent/minimize limitations and disabilities due to CLBP. PMID:25633930

  12. Effect of Pr Valence State on Interfacial Structure and Electrical Properties of Pr Oxide/PrON/Ge Gate Stack Structure

    NASA Astrophysics Data System (ADS)

    Kato, Kimihiko; Sakashita, Mitsuo; Takeuchi, Wakana; Kondo, Hiroki; Nakatsuka, Osamu; Zaima, Shigeaki

    2011-04-01

    In this study, we investigated the valence state and chemical bonding state of Pr in a Pr oxide/PrON/Ge structure. We clarified the relationship between the valence state of Pr and the Pr oxide/Ge interfacial reaction using Pr oxide/Ge and Pr oxide/PrON/Ge samples. We found the formation of three Pr oxide phases in Pr oxide films; hexagonal Pr2O3 (h-Pr2O3) (Pr3+), cubic Pr2O3 (c-Pr2O3) (Pr3+), and c-PrO2 (Pr4+). We also investigated the effect of a nitride interlayer on the interfacial reaction in Pr oxide/Ge gate stacks. In a sample with a nitride interlayer (Pr oxide/PrON/Ge), metallic Pr-Pr bonds are also formed in the c-Pr2O3 film. After annealing in H2 ambient, the diffusion of Ge into Pr oxide is not observed in this sample. Pr-Pr bonds probably prevent the interfacial reaction and Ge oxide formation, considering that the oxygen chemical potential of this film is lower than that of a GeO2/Ge system. On the other hand, the rapid thermal oxidation (RTO) treatment terminates the O vacancies and defects in c-Pr2O3. As a result, c-PrO2 with tetravalent Pr is formed in the Pr oxide/PrON/Ge sample with RTO. In this sample, the leakage current density is effectively decreased in comparison with the sample without RTO. Hydrogen termination works effectively in Pr oxide/PrON/Ge samples with and without RTO, and we can achieve an interface state density of as low as 4 ×1011 eV-1·cm-2.

  13. Brazil: Xingu River

    Atmospheric Science Data Center

    2013-04-18

    ... title:  Fire and Deforestation near the Xingu River     View Larger Image Numerous fires occurred near the headwaters of the Xingu River and the Xingu Indigenous Peoples' Reserve in Mato Grosso, Brazil, during ...

  14. Social Studies in Brazil.

    ERIC Educational Resources Information Center

    Searles, John E.

    1979-01-01

    Discusses the role of social studies in transmitting the cultural heritage of Brazil. Includes descriptions of Brazilian culture and the educational structure. Journal availability: see SO 506 831. (AV)

  15. Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil

    PubMed Central

    2011-01-01

    Background Childhood cancer differs from most common adult cancers, suggesting a distinct aetiology for some types of childhood cancer. Our objective in this study was to test the difference in incidence rates of 4 non-CNS embryonic tumours and their correlation with socioeconomic status (SES) in Brazil. Methods Data was obtained from 13 Brazilian population-based cancer registries (PBCRs) of neuroblastoma (NB), Wilms'tumour (WT), retinoblastoma (RB), and hepatoblastoma (HB). Incidence rates by tumour type, age, and gender were calculated per one million children. Correlations between social exclusion index (SEI) as an indicator of socioeconomic status (SES) and incidence rates was investigated using the Spearman's test. Results WT, RB, and HB presented with the highest age-adjusted incidence rates (AAIRs) in 1 to 4 year old of both genders, whereas NB presented the highest AAIR in ≤11 month-olds. However, differences in the incidence rates among PBCRs were observed. Higher incidence rates were found for WT and RB, whereas lower incidence rates were observed for NB. Higher SEI was correlated with higher incidences of NB (0.731; p = 0.0117), whereas no SEI correlation was observed between incidence rates for WT, RB, and HB. In two Brazilian cities, the incidence rates of NB and RB were directly correlated with SEI; NB had the highest incidence rates (14.2, 95% CI, 8.6-19.7), and RB the lowest (3.5, 95% CI, 0.7-6.3) in Curitiba (SEI, 0.730). In Natal (SEI, 0.595), we observed just the opposite; the highest incidence rate was for RB and the lowest was for NB (4.6, 95% CI, 0.1-9.1). Conclusion Regional variations of SES and the incidence of embryonal tumours were observed, particularly incidence rates for NB and RB. Further studies are necessary to investigate risk factors for embryonic tumours in Brazil. PMID:21545722

  16. Transverse Wobbling in 135Pr

    NASA Astrophysics Data System (ADS)

    Matta, J. T.; Garg, U.; Li, W.; Frauendorf, S.; Ayangeakaa, A. D.; Patel, D.; Schlax, K. W.; Palit, R.; Saha, S.; Sethi, J.; Trivedi, T.; Ghugre, S. S.; Raut, R.; Sinha, A. K.; Janssens, R. V. F.; Zhu, S.; Carpenter, M. P.; Lauritsen, T.; Seweryniak, D.; Chiara, C. J.; Kondev, F. G.; Hartley, D. J.; Petrache, C. M.; Mukhopadhyay, S.; Lakshmi, D. Vijaya; Raju, M. Kumar; Madhusudhana Rao, P. V.; Tandel, S. K.; Ray, S.; Dönau, F.

    2015-02-01

    A pair of transverse wobbling bands is observed in the nucleus 135Pr . The wobbling is characterized by Δ I =1 , E 2 transitions between the bands, and a decrease in the wobbling energy confirms its transverse nature. Additionally, a transition from transverse wobbling to a three-quasiparticle band comprised of strong magnetic dipole transitions is observed. These observations conform well to results from calculations with the tilted axis cranking model and the quasiparticle rotor model.

  17. Precambrian Cratons and Fold-Belts in Brazil: Overview

    NASA Astrophysics Data System (ADS)

    Fuck, R.

    2008-05-01

    The main Precambrian terrains recognized in Brazil comprise the Amazonian, São Francisco and Rio de la Plata cratons, surrounded by Neoproterozoic Brasiliano fold belts, making up the Borborema, Mantiqueira and Tocantins provinces. The Amazonian craton comprises an Archean core, surrounded by Paleoproterozoic terrains (Maroni-Itacaiunas, Ventuari-Tapajós, Rio Negro-Juruena), which southwestwards give way to the Mesoproterozoic Rondoniano-San Ignacio and Sunsas belts, the latter thought to be related to the Grenville belt of North America. The São Francisco craton comprises several Archean blocks (Gavião, Serrinha, Jequié) amalgamated by the Paleoproterozoic high-grade Itabuna-Salvador-Curaçá orogen. The Rio de la Plata craton, largely covered by Phanerozoic strata, is made of Paleoproterozoic basement gneiss and several Paleoproterozoic greenstone belts. Other cratonic blocks are hidden below large Phanerozoic basins, like the Paranapanema and Parnaíba blocks below the Paraná and Parnaíba basins, respectively. Several smaller Archean/Paleoproterozoic blocks appear within the Brasiliano provinces: some were strongly reworked during the Neoproterozoic orogenic events (São José do Campestre, Pernambuco-Alagoas, Goiás, Guanhães, Juiz de Fora, Curitiba), others were only marginally affected (São Luiz, Rio Apa, Luís Alves). The Brasiliano provinces are the result of Neoproterozoic to early Paleozoic orogenic events within the framework of West Gondwana amalgamation. The Mantiqueira Province extends from eastern Brazil to southern Uruguay and includes the Araçuaí, Ribeira and Dom Feliciano fold belts, bordering the São Francisco, Paranapanema and Rio de la Plata cratons and surrounding the Luís Alves craton. The Tocantins province in central Brazil includes the Araguaia, Paraguay and Brasília fold belts, the former bordering the Amazonian craton, the second bordering both the southern Amazonian craton and the Rio Apa block, and the last established on

  18. Vaccine protection against Zika virus from Brazil.

    PubMed

    Larocca, Rafael A; Abbink, Peter; Peron, Jean Pierre S; Zanotto, Paolo M de A; Iampietro, M Justin; Badamchi-Zadeh, Alexander; Boyd, Michael; Ng'ang'a, David; Kirilova, Marinela; Nityanandam, Ramya; Mercado, Noe B; Li, Zhenfeng; Moseley, Edward T; Bricault, Christine A; Borducchi, Erica N; Giglio, Patricia B; Jetton, David; Neubauer, George; Nkolola, Joseph P; Maxfield, Lori F; De La Barrera, Rafael A; Jarman, Richard G; Eckels, Kenneth H; Michael, Nelson L; Thomas, Stephen J; Barouch, Dan H

    2016-08-25

    Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global health priority, but very little is currently known about ZIKV immunology and mechanisms of immune protection. Here we show that a single immunization with a plasmid DNA vaccine or a purified inactivated virus vaccine provides complete protection in susceptible mice against challenge with a strain of ZIKV involved in the outbreak in northeast Brazil. This ZIKV strain has recently been shown to cross the placenta and to induce fetal microcephaly and other congenital malformations in mice. We produced DNA vaccines expressing ZIKV pre-membrane and envelope (prM-Env), as well as a series of deletion mutants. The prM-Env DNA vaccine, but not the deletion mutants, afforded complete protection against ZIKV, as measured by absence of detectable viraemia following challenge, and protective efficacy correlated with Env-specific antibody titers. Adoptive transfer of purified IgG from vaccinated mice conferred passive protection, and depletion of CD4 and CD8 T lymphocytes in vaccinated mice did not abrogate this protection. These data demonstrate that protection against ZIKV challenge can be achieved by single-shot subunit and inactivated virus vaccines in mice and that Env-specific antibody titers represent key immunologic correlates of protection. Our findings suggest that the development of a ZIKV vaccine for humans is likely to be achievable.

  19. Vaccine protection against Zika virus from Brazil.

    PubMed

    Larocca, Rafael A; Abbink, Peter; Peron, Jean Pierre S; Zanotto, Paolo M de A; Iampietro, M Justin; Badamchi-Zadeh, Alexander; Boyd, Michael; Ng'ang'a, David; Kirilova, Marinela; Nityanandam, Ramya; Mercado, Noe B; Li, Zhenfeng; Moseley, Edward T; Bricault, Christine A; Borducchi, Erica N; Giglio, Patricia B; Jetton, David; Neubauer, George; Nkolola, Joseph P; Maxfield, Lori F; De La Barrera, Rafael A; Jarman, Richard G; Eckels, Kenneth H; Michael, Nelson L; Thomas, Stephen J; Barouch, Dan H

    2016-08-25

    Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both humans and mice. The rapid development of a safe and effective ZIKV vaccine is a global health priority, but very little is currently known about ZIKV immunology and mechanisms of immune protection. Here we show that a single immunization with a plasmid DNA vaccine or a purified inactivated virus vaccine provides complete protection in susceptible mice against challenge with a strain of ZIKV involved in the outbreak in northeast Brazil. This ZIKV strain has recently been shown to cross the placenta and to induce fetal microcephaly and other congenital malformations in mice. We produced DNA vaccines expressing ZIKV pre-membrane and envelope (prM-Env), as well as a series of deletion mutants. The prM-Env DNA vaccine, but not the deletion mutants, afforded complete protection against ZIKV, as measured by absence of detectable viraemia following challenge, and protective efficacy correlated with Env-specific antibody titers. Adoptive transfer of purified IgG from vaccinated mice conferred passive protection, and depletion of CD4 and CD8 T lymphocytes in vaccinated mice did not abrogate this protection. These data demonstrate that protection against ZIKV challenge can be achieved by single-shot subunit and inactivated virus vaccines in mice and that Env-specific antibody titers represent key immunologic correlates of protection. Our findings suggest that the development of a ZIKV vaccine for humans is likely to be achievable. PMID:27355570

  20. [A better Brazil].

    PubMed

    Lesser, Jeffrey

    2014-01-01

    Many countries in the Americas describe themselves as "nations of immigrants." In the United States, the myth of the "promised land" suggests that foreigners better themselves upon arrival because the nation is intrinsically great. In Brazil, however, the relationship between immigration and national identity is different. Many intellectuals, politicians, and cultural and economic leaders saw (and see) immigrants as improving an imperfect nation that has been tainted by the history of Portuguese colonialism and African slavery. As a result, immigrants were often hailed as saviors because they modified and improved Brazil, not because they were improved by Brazil. This "improvement" took place through absorption, mixture and with the use of increasingly flexible racial and ethnic categories.

  1. Health care in Brazil.

    PubMed Central

    Haines, A

    1993-01-01

    Brazil has great geopolitical importance because of its size, environmental resources, and potential economic power. The organisation of its health care system reflects the schisms within Brazilian society. High technology private care is available to the rich and inadequate public care to the poor. Limited financial resources have been overconcentrated on health care in the hospital sector and health professionals are generally inappropriately trained to meet the needs of the community. However, recent changes in the organisation of health care are taking power away from federal government to state and local authorities. This should help the process of reform, but many vested interests remain to be overcome. A link programme between Britain and Brazil focusing on primary care has resulted in exchange of ideas and staff between the two countries. If primary care in Brazil can be improved it could help to narrow the health divide between rich and poor. Images p503-a p504-a p505-a PMID:8448465

  2. [A better Brazil].

    PubMed

    Lesser, Jeffrey

    2014-01-01

    Many countries in the Americas describe themselves as "nations of immigrants." In the United States, the myth of the "promised land" suggests that foreigners better themselves upon arrival because the nation is intrinsically great. In Brazil, however, the relationship between immigration and national identity is different. Many intellectuals, politicians, and cultural and economic leaders saw (and see) immigrants as improving an imperfect nation that has been tainted by the history of Portuguese colonialism and African slavery. As a result, immigrants were often hailed as saviors because they modified and improved Brazil, not because they were improved by Brazil. This "improvement" took place through absorption, mixture and with the use of increasingly flexible racial and ethnic categories. PMID:24789488

  3. Brazil's mental health adventure.

    PubMed

    Weingarten, Richard

    2003-01-01

    This is an account of my trips to Brazil in 2001 where I worked on a series of mental health projects with Brazilian colleagues. I first got interested in Brazil after I graduated from college when I was a Peace Corps volunteer in Northeast Brazil (Bahia state). After I got out of the Peace Corps I moved to Rio de Janeiro and went to work for United Press International (UPI) in their Rio bureau. I was UPI foreign news correspondent for a year and a half. Those years in Brazil were probably the happiest years of my life. Later on, after I became ill in the U.S., my Brazilian connection played an important role in my recovery. Raised in a Victorian family in a small town in the Midwest, and schooled in a traditional boarding school for boys and then at an all men's college, Brazil's lively Latino culture served as a healthy antidote for my tendency to be reserved and often depressed. My contact with Brazilians and Brazilian culture always beckoned me on. I maintained contact with my friends in Brazil and they stuck by me through my illness years. What seemed like my emotional and intellectual "excess" to me, was easily accepted by my Brazilian friends. I felt much more myself interacting with Brazilians and connected to a larger sense of self I developed in Brazil. I traveled to Brazil at every opportunity and made friends with Brazilians I met in the States. I initiated Portuguese classes at John Carroll University in Cleveland, Ohio in the early 1990s and then was invited to teach Brazilian culture to undergraduates. These appointments and my own resilience moved me past one depression and a dysthymia condition and into the wider community. I regained my confidence as a teacher, a role I had before and during the years of my illness. From this position, I organized a club for Brazilian students studying in the Cleveland area. After this teaching stint, I felt ready to pursue full time employment and began a job search that would eventually land me in New Haven at

  4. Brazil's mental health adventure.

    PubMed

    Weingarten, Richard

    2003-01-01

    This is an account of my trips to Brazil in 2001 where I worked on a series of mental health projects with Brazilian colleagues. I first got interested in Brazil after I graduated from college when I was a Peace Corps volunteer in Northeast Brazil (Bahia state). After I got out of the Peace Corps I moved to Rio de Janeiro and went to work for United Press International (UPI) in their Rio bureau. I was UPI foreign news correspondent for a year and a half. Those years in Brazil were probably the happiest years of my life. Later on, after I became ill in the U.S., my Brazilian connection played an important role in my recovery. Raised in a Victorian family in a small town in the Midwest, and schooled in a traditional boarding school for boys and then at an all men's college, Brazil's lively Latino culture served as a healthy antidote for my tendency to be reserved and often depressed. My contact with Brazilians and Brazilian culture always beckoned me on. I maintained contact with my friends in Brazil and they stuck by me through my illness years. What seemed like my emotional and intellectual "excess" to me, was easily accepted by my Brazilian friends. I felt much more myself interacting with Brazilians and connected to a larger sense of self I developed in Brazil. I traveled to Brazil at every opportunity and made friends with Brazilians I met in the States. I initiated Portuguese classes at John Carroll University in Cleveland, Ohio in the early 1990s and then was invited to teach Brazilian culture to undergraduates. These appointments and my own resilience moved me past one depression and a dysthymia condition and into the wider community. I regained my confidence as a teacher, a role I had before and during the years of my illness. From this position, I organized a club for Brazilian students studying in the Cleveland area. After this teaching stint, I felt ready to pursue full time employment and began a job search that would eventually land me in New Haven at

  5. Predicting urban outdoor thermal comfort by the Universal Thermal Climate Index UTCI—a case study in Southern Brazil

    NASA Astrophysics Data System (ADS)

    Bröde, Peter; Krüger, Eduardo L.; Rossi, Francine A.; Fiala, Dusan

    2012-05-01

    Recognising that modifications to the physical attributes of urban space are able to promote improved thermal outdoor conditions and thus positively influence the use of open spaces, a survey to define optimal thermal comfort ranges for passers-by in pedestrian streets was conducted in Curitiba, Brazil. We applied general additive models to study the impact of temperature, humidity, and wind, as well as long-wave and short-wave radiant heat fluxes as summarised by the recently developed Universal Thermal Climate Index (UTCI) on the choice of clothing insulation by fitting LOESS smoothers to observations from 944 males and 710 females aged from 13 to 91 years. We further analysed votes of thermal sensation compared to predictions of UTCI. The results showed that females chose less insulating clothing in warm conditions compared to males and that observed values of clothing insulation depended on temperature, but also on season and potentially on solar radiation. The overall pattern of clothing choice was well reflected by UTCI, which also provided for good predictions of thermal sensation votes depending on the meteorological conditions. Analysing subgroups indicated that the goodness-of-fit of the UTCI was independent of gender and age, and with only limited influence of season and body composition as assessed by body mass index. This suggests that UTCI can serve as a suitable planning tool for urban thermal comfort in sub-tropical regions.

  6. Predicting urban outdoor thermal comfort by the Universal Thermal Climate Index UTCI--a case study in Southern Brazil.

    PubMed

    Bröde, Peter; Krüger, Eduardo L; Rossi, Francine A; Fiala, Dusan

    2012-05-01

    Recognising that modifications to the physical attributes of urban space are able to promote improved thermal outdoor conditions and thus positively influence the use of open spaces, a survey to define optimal thermal comfort ranges for passers-by in pedestrian streets was conducted in Curitiba, Brazil. We applied general additive models to study the impact of temperature, humidity, and wind, as well as long-wave and short-wave radiant heat fluxes as summarised by the recently developed Universal Thermal Climate Index (UTCI) on the choice of clothing insulation by fitting LOESS smoothers to observations from 944 males and 710 females aged from 13 to 91 years. We further analysed votes of thermal sensation compared to predictions of UTCI. The results showed that females chose less insulating clothing in warm conditions compared to males and that observed values of clothing insulation depended on temperature, but also on season and potentially on solar radiation. The overall pattern of clothing choice was well reflected by UTCI, which also provided for good predictions of thermal sensation votes depending on the meteorological conditions. Analysing subgroups indicated that the goodness-of-fit of the UTCI was independent of gender and age, and with only limited influence of season and body composition as assessed by body mass index. This suggests that UTCI can serve as a suitable planning tool for urban thermal comfort in sub-tropical regions.

  7. Chikungunya risk for Brazil

    PubMed Central

    Azevedo, Raimunda do Socorro da Silva; Oliveira, Consuelo Silva; Vasconcelos, Pedro Fernando da Costa

    2015-01-01

    This study aimed to show, based on the literature on the subject, the potential for dispersal and establishment of the chikungunya virus in Brazil. The chikungunya virus, a Togaviridae member of the genus Alphavirus, reached the Americas in 2013 and, the following year, more than a million cases were reported. In Brazil, indigenous transmission was registered in Amapa and Bahia States, even during the period of low rainfall, exposing the whole country to the risk of virus spreading. Brazil is historically infested by Ae. aegypti and Ae. albopictus, also dengue vectors. Chikungunya may spread, and it is important to take measures to prevent the virus from becoming endemic in the country. Adequate care for patients with chikungunya fever requires training general practitioners, rheumatologists, nurses, and experts in laboratory diagnosis. Up to November 2014, more than 1,000 cases of the virus were reported in Brazil. There is a need for experimental studies in animal models to understand the dynamics of infection and the pathogenesis as well as to identify pathophysiological mechanisms that may contribute to identifying effective drugs against the virus. Clinical trials are needed to identify the causal relationship between the virus and serious injuries observed in different organs and joints. In the absence of vaccines or effective drugs against the virus, currently the only way to prevent the disease is vector control, which will also reduce the number of cases of dengue fever. PMID:26398876

  8. Human Pythiosis, Brazil

    PubMed Central

    Bosco, Sandra de Moraes Gimenes; Araújo, João Pessoa; Candeias, João Manuel Grisi; Fabiano de Franco, Marcello; Marques, Mariangela Esther Alencar; Mendoza, Leonel; Pires de Camargo, Rosangela; Marques, Silvio Alencar

    2005-01-01

    Pythiosis, caused by Pythium insidiosum, occurs in humans and animals and is acquired from aquatic environments that harbor the emerging pathogen. Diagnosis is difficult because clinical and histopathologic features are not pathognomonic. We report the first human case of pythiosis from Brazil, diagnosed by using culture and rDNA sequencing. PMID:15890126

  9. Brazil: Rio Branco

    Atmospheric Science Data Center

    2013-04-18

    article title:  Deforestation near Rio Branco, Brazil     View Larger Image Settlement and deforestation surrounding the Brazilian town of Rio Branco are seen here in the striking "herring bone" deforestation patterns that cut through the rainforest. Rio Branco is the ...

  10. Chikungunya risk for Brazil.

    PubMed

    Azevedo, Raimunda do Socorro da Silva; Oliveira, Consuelo Silva; Vasconcelos, Pedro Fernando da Costa

    2015-01-01

    This study aimed to show, based on the literature on the subject, the potential for dispersal and establishment of the chikungunya virus in Brazil. The chikungunya virus, a Togaviridae member of the genusAlphavirus, reached the Americas in 2013 and, the following year, more than a million cases were reported. In Brazil, indigenous transmission was registered in Amapa and Bahia States, even during the period of low rainfall, exposing the whole country to the risk of virus spreading. Brazil is historically infested by Ae. aegypti and Ae. albopictus, also dengue vectors. Chikungunya may spread, and it is important to take measures to prevent the virus from becoming endemic in the country. Adequate care for patients with chikungunya fever requires training general practitioners, rheumatologists, nurses, and experts in laboratory diagnosis. Up to November 2014, more than 1,000 cases of the virus were reported in Brazil. There is a need for experimental studies in animal models to understand the dynamics of infection and the pathogenesis as well as to identify pathophysiological mechanisms that may contribute to identifying effective drugs against the virus. Clinical trials are needed to identify the causal relationship between the virus and serious injuries observed in different organs and joints. In the absence of vaccines or effective drugs against the virus, currently the only way to prevent the disease is vector control, which will also reduce the number of cases of dengue fever.

  11. English Teaching Profile: Brazil.

    ERIC Educational Resources Information Center

    British Council, London (England). English Language and Literature Div.

    This review of the status of English language instruction in Brazil provides an overview of the Brazilian geographic, historical, and political context and the role of English in the society in general and in the educational system. The following topics are covered: an outline of the status of English use and instruction in the educational system…

  12. Adult Education in Brazil.

    ERIC Educational Resources Information Center

    Ministerio da Educacao e Cultura, Rio de Janeiro (Brazil).

    The status and goals of adult education programs in Brazil are discussed in this report. Supplemental systems such as the Brazilian Literacy Movement (Mobral) and their results are described and evaluated. Charts detailing the evolution of literacy are shown and priorities in education are suggested. The progress of other educational entities is…

  13. PrPs: Proteins with a purpose

    PubMed Central

    Sempou, Emily

    2009-01-01

    The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform. Much less understood is how this misfolded isoform causes deadly brain illnesses. Neurodegeneration in prion disease is often seen as a consequence of abnormal PrP function yet, amazingly little is known about the normal, physiological role of PrP. In particular, the absence of obvious phenotypes in PrP knockout mice has prevented scientists from answering this important question. Using knockdown approaches, we previously produced clear PrP loss-of-function phenotypes in zebrafish embryos. Analysis of these phenotypes revealed that PrP can modulate E-cadherin-based cell-cell adhesion, thereby controlling essential morphogenetic cell movements in the early gastrula. Our data also showed that PrP itself can elicit homophilic cell-cell adhesion and trigger intracellular signaling via Src-related kinases. Importantly, these molecular functions of PrP are conserved from fish to mammals. Here we discuss the use of the zebrafish in prion biology and how it may advance our understanding of the roles of PrP in health and disease. PMID:19786844

  14. ESO PR Highlights in 2003

    NASA Astrophysics Data System (ADS)

    2004-01-01

    Among the many astronomical highlights of 2003, the Transit of Mercury certainly attracted great attention as shown by the record number of hits the ESO web page received on that day. But this was a mere rehearsal of an even bigger event we will enjoy in 2004: the Venus Transit. ESO, in partnership with several institutions, is organising a major educational event in connection with it. During 2003, the ESO Educational Office was also involved in various other programmes. They included the web-based "Catch a Star!" and the "Physics and Life" projects, organised with EC sponsorship in connection with the 2003 European Science and Technology Week. The ALMA project, an European-North American collaboration to build an array of 64 12-m submillimetre antennas, moved forward with the signature of the agreement between ESO and the NSF and with the Ground-breaking at Chajnantor. Conceptual studies of a 100-m optical/infrared telescope (OWL) also proceeded well. Several new instruments were installed at ESO telescopes, e.g. HARPS . And the VLT Interferometer (VLTI) received a powerful Adaptive Optics System and made the first detection through infrared interferometry of an extragalactic object. A rapidly increasing number of new scientific results were obtained on the basis of data from ESO telescopes, some of which were highlighted in ESO Press Releases. A number of beautiful images were published. Many of these developments are described in ESO's Press Releases, most with Press Photos, cf. the 2003 PR Index. Some of last year's ESO PR highlights may be accessed directly via the clickable image above.

  15. Level of asthma control and its impact on activities of daily living in asthma patients in Brazil*

    PubMed Central

    Gazzotti, Mariana Rodrigues; Nascimento, Oliver Augusto; Montealegre, Federico; Fish, James; Jardim, José Roberto

    2013-01-01

    OBJECTIVE: To evaluate the impact of asthma on activities of daily living and on health status in patients with controlled, partially controlled, or uncontrolled asthma in Brazil. METHODS: We used data related to 400 patients in four Brazilian cities (São Paulo, Rio de Janeiro, Salvador, and Curitiba), obtained in a survey conducted throughout Latin America in 2011. All study subjects were > 12 years of age and completed a standardized questionnaire in face-to-face interviews. The questions addressed asthma control, hospitalizations, emergency room visits, and school/work absenteeism, as well as the impact of asthma on the quality of life, sleep, and leisure. The level of asthma control was determined in accordance with the Global Initiative for Asthma criteria. RESULTS: Among the 400 respondents, asthma was controlled in 37 (9.3%), partially controlled in 226 (56.5%), and uncontrolled in 137 (34.2%). The numbers of patients with uncontrolled or partially controlled asthma who visited the emergency room, who were hospitalized, and who missed school/work were higher than were those of patients with controlled asthma (p = 0.001, p = 0.05, and p = 0.01, respectively). Among those with uncontrolled asthma, the impact of the disease on activities of daily living, sleep, social activities, and normal physical exertion was greater than it was among those with controlled or partially controlled asthma (p < 0.001). CONCLUSIONS: In Brazil, asthma treatment should be monitored more closely in order to increase treatment adherence and, consequently, the level of asthma control, which can improve patient quality of life and minimize the negative impact of the disease. PMID:24310625

  16. Practical PR for School Media Centers.

    ERIC Educational Resources Information Center

    Beasley, Augie E.; Palmer, Carolyn G.

    This guide to public relations (PR) for school media specialists begins with a list of 10 "PR Commandments" and suggestions for ways to improve the media center's image, i.e., a media newsletter; renewal workshops; reference skills units; a student brochure; new faculty orientation; media messages; a happenings board; displays, centers, and…

  17. Deforestation, Rondonia, Brazil

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This view of deforestation in Rondonia, far western Brazil, (10.0S, 63.0W) is part of an agricultural resettlement project which ultimately covers an area about 80% the size of France. The patterns of deforestation in this part of the Amazon River Basin are usually aligned adjacent to highways, secondary roads, and streams for ease of access and transportation. Compare this view with the earlier 51G-37-062 for a comparison of deforestation in the region.

  18. IPPs in Brazil

    SciTech Connect

    Alqueres, J.L.

    1995-01-01

    Brazil offers a viable opportunity for independent power producers (IPPs). Four areas of the Brazilian power sector may be the potential starting points for an independent power industry. Recent legislation also has opened the doors for IPP activity by allowing companies to form consortia to generate power for their own needs. Another recent decree formed the basis for a grid system to which generators can sell power. This also has laid the groundwork for more clearly defined wheeling charges.

  19. Health promotion in Brazil.

    PubMed

    Ivo de Carvalho, Antonio; Westphal, Marcia Faria; Pereira Lima, Vera Lucia Góes

    2007-01-01

    Brazil, a Latin American country of continental proportions and contrasts, demographic inequalities, and social inequities, concomitantly faces the challenge of preventing and controlling infectious diseases, injuries, and non-communicable diseases. The loss of strength of the biomedical paradigm, the change in epidemiological profile, and the sociopolitical and cultural challenges of recent decades have fostered the emergence of new formulations about public health thinking and practice. Among them, are the paradigms of Brazilian Collective Health and Health Promotion. The former provides philosophical support for Brazil's Unified Health System (SUS). The aim of this article is to discuss the development of public health within the country's history, and to analyze and compare the theoretical assumptions of Health Promotion and Collective Health. We conclude that health promotion, based on the principles and values disseminated by the international Charters and concerned with social actors and social determinants of the health-disease process, has significant potential to promote the improvement of living and health conditions of the population. This frame of reference guided the formulation of the National Policy of Health Promotion within the Unified Health System, which was institutionalized by a ministerial decree. The importance and application of evaluating the effectiveness of health promotion processes and methodologies in Brazil have been guided by various frames of reference, which we clarify in this article through describing historical processes.

  20. Health promotion in Brazil.

    PubMed

    Ivo de Carvalho, Antonio; Westphal, Marcia Faria; Pereira Lima, Vera Lucia Góes

    2007-01-01

    Brazil, a Latin American country of continental proportions and contrasts, demographic inequalities, and social inequities, concomitantly faces the challenge of preventing and controlling infectious diseases, injuries, and non-communicable diseases. The loss of strength of the biomedical paradigm, the change in epidemiological profile, and the sociopolitical and cultural challenges of recent decades have fostered the emergence of new formulations about public health thinking and practice. Among them, are the paradigms of Brazilian Collective Health and Health Promotion. The former provides philosophical support for Brazil's Unified Health System (SUS). The aim of this article is to discuss the development of public health within the country's history, and to analyze and compare the theoretical assumptions of Health Promotion and Collective Health. We conclude that health promotion, based on the principles and values disseminated by the international Charters and concerned with social actors and social determinants of the health-disease process, has significant potential to promote the improvement of living and health conditions of the population. This frame of reference guided the formulation of the National Policy of Health Promotion within the Unified Health System, which was institutionalized by a ministerial decree. The importance and application of evaluating the effectiveness of health promotion processes and methodologies in Brazil have been guided by various frames of reference, which we clarify in this article through describing historical processes. PMID:17596091

  1. Positive self-rated health in the elderly: a population-based study in the South of Brazil.

    PubMed

    Confortin, Susana Cararo; Giehl, Maruí Weber Corseuil; Antes, Danielle Ledur; Schneider, Ione Jayce Ceola; d'Orsi, Eleonora

    2015-05-01

    The objective was to identify factors associated with positive self-rated health in the elderly in Florianópolis, Santa Catarina State, in the South of Brazil. This population-based cross-sectional study evaluated 1,705 elderly. Self-rated health was classified as positive (very good or good) or negative (fair, poor, and very poor). Crude and adjusted Poisson regression was used to identify associated factors. Prevalence of positive self-rated health was 51.2%, associated with male gender (PR = 1.13), more than 5 years of schooling, moderate (PR = 1.33) or high alcohol intake (PR = 1.37), leisure-time activity (PR = 1.20), Internet use (PR = 1.21), fewer diseases, mild/moderate dependence (PR = 2.20) or no dependence (PR = 2.67), no falls (PR = 1.19), and non-use of polypharmacy (PR = 1.27). Several modifiable factors were identified that can affect positive self-rated health in the elderly and contribute to the development of strategies to improve their quality of life.

  2. Violence against children: an analysis of mandatory reporting of violence, Brazil 2011.

    PubMed

    Rates, Susana Maria Moreira; de Melo, Elza Machado; Mascarenhas, Márcio Dênis Medeiros; Malta, Deborah Carvalho

    2015-03-01

    This article aims to describe and analyze reporting of violence against children from 0 to 9 years of age, issued by the public health services, in Brazil. Data from the Violence and Accident Surveillance System (Viva-SINAN) were used. The frequency of selected variables was calculated by age group (0-1; 2-5 and 6-9 years of age) as well as their Prevalence Ratios (PR). 17.900 cases were reported: 33% in the 0-1 year group; 35,8% in the 2-5 year group; and 31,2% in the 6-9 year group. Physical violence predominated among boys (PR: 1.22; CI 95%: 1,16-1,28 ); 6-9 years old (PR: 1,19; CI 95%: 1,12-1.27 ). Sexual violence predominated among girls, mulatto/afro-descendant (PR: 1.12; CI 95 %: 1.06 to 1.19 ); 6-9 years (PR: 4.63; CI 95%: 4.22- 5.08) with more chances of occurring at home (PR: 1.38 , CI: 95%: 1.29-1.48); psychological violence prevailed among girls, mulatto/afro-descendant (PR: 1.10; CI 95 %: 1.03-1.18 ), 6-9 years old (PR: 2.95; CI 95%: 2.69- 3.23), at home (PR: 1.40; CI 95%: 1.29-1.53); negligence predominated among boys (PR: 1.33 ; 95% CI: 1.27-1.39); 0-1 years and their parents were the most prevalent perpetrators.The results indicate the need to strengthen intersectoral actions aiming at extending the social protection and care network.

  3. [Functions of prion protein PrPc].

    PubMed

    Cazaubon, Sylvie; Viegas, Pedro; Couraud, Pierre-Olivier

    2007-01-01

    It is now well established that both normal and pathological (or scrapie) isoforms of prion protein, PrPc and PrPsc respectively, are involved in the development and progression of various forms of neurodegenerative diseases, including scrapie in sheep, bovine spongiform encephalopathy (or "mad cow disease") and Creutzfeldt-Jakob disease in human, collectively known as prion diseases. The protein PrPc is highly expressed in the central nervous system in neurons and glial cells, and also present in non-brain cells, such as immune cells or epithelial and endothelial cells. Identification of the physiological functions of PrPc in these different cell types thus appears crucial for understanding the progression of prion diseases. Recent studies highlighted several major roles for PrPc that may be considered in two major domains : (1) cell survival (protection against oxidative stress and apoptosis) and (2) cell adhesion. In association with cell adhesion, distinct functions of PrPc were observed, depending on cell types : neuronal differentiation, epithelial and endothelial barrier integrity, transendothelial migration of monocytes, T cell activation. These observations suggest that PrPc functions may be particularly relevant to cellular stress, as well as inflammatory or infectious situations. PMID:17875293

  4. Brazil: Intercultural Experiential Learning Aid.

    ERIC Educational Resources Information Center

    Brigham Young Univ., Provo, UT. Language Research Center.

    This booklet was designed to facilitate interactions and communication with the people of Brazil by providing information about their customs, attitudes and other cultural characteristics which influence their actions and values. A brief description of Brazil is given, covering the following: its size and geography, history, language, economy,…

  5. A Comprehensive View of Brazil.

    ERIC Educational Resources Information Center

    Texas Education Agency, Austin.

    This student and teacher resource discusses the geography, history, and contemporary changes and achievements of Brazil. It is intended to complement textbooks and other teaching materials by serving as a resource for teachers, administrators, and students. The document is presented in three parts. Part I focuses on the geography of Brazil,…

  6. Group 2 vaccinia virus, Brazil.

    PubMed

    Assis, Felipe Lopes; Borges, Iara Apolinario; Ferreira, Paulo César Peregrino; Bonjardim, Cláudio Antônio; Trindade, Giliane de Souza; Lobato, Zélia Inês Portela; Guedes, Maria Isabel Maldonado; Mesquita, Vaz; Kroon, Erna Geessien; Abrahão, Jônatas Santos

    2012-12-01

    In 2011, vaccinia virus caused an outbreak of bovine vaccinia, affecting dairy cattle and dairy workers in Brazil. Genetic and phenotypic analyses identified this isolate as distinct from others recently identified, thereby reinforcing the hypothesis that different vaccinia virus strains co-circulate in Brazil.

  7. Upward Lightning in Brazil

    NASA Astrophysics Data System (ADS)

    Schumann, C.; Saba, M. M.; Alves, J.; Warner, T. A.; Albrecht, R. I.; Bie, L. L.

    2012-12-01

    Observations of upward lightning from tall objects have been reported since 1939. Interest in this subject has grown recently, some of it because of the rapid expansion of wind power generation. Also, with the increasing number of tall buildings and towers, there will be a corresponding increase in the number of upward lightning flashes from these structures. Reports from recent field observations are beginning to address the nature of upward lightning initiation, but much still needs to be learned. Examples are studies of upward lightning from towers in winter thunderstorms in Japan (Wang and Takagi, 2010; and Lu et al., 2009) and summer thunderstorms in Europe (Miki et al., 2005; Flache et al., 2008; and Diendorfer et al., 2009; Zhou et al., 2011) and in North America (Mazur and Ruhnke, 2011; Hussein et al., 2011; Warner, 2011, and Warner et al., 2011). Up to January 2012, no upward flash had ever been registered in Brazil. With the help of some video cameras, we recorded 15 upward lightning which started from one of the towers located on Peak Jaraguá in the city of São Paulo. This paper describes the first results of this field campaign. A combination of high-speed video and standard definition video were used to record upward lightning flashes from multiple towers in Sao Paulo, Brazil, a city located in southeastern Brazil with a population over 10 million people, an average elevation of around 800 meters above sea level, and a flash density of 15 flashes/km2/year. Observations of 15 upward flashes made with these assets were analyzed along with BrasilDAT Lightning Detection Network and a lightning mapping array (LMA) and electric field sensors.

  8. Astronomy in Brazil

    NASA Astrophysics Data System (ADS)

    Barbuy, Beatriz; Maciel, Walter J.

    2013-01-01

    A historical background combined with political decisions along time explain the increasing importance of Brazil in the world's astronomical scenario. Professional astronomy was triggered in the late sixties and early seventies by the two main historical institutions then existing (ON and IAG/USP), together with the creation of agencies for research and combined with individual actions. There are presently 670 astronomers working in the country, including permanent jobs and graduate students. A brief description of observational facilities and plans to increase access to other facilities is presented.

  9. Social Psychotherapy in Brazil.

    PubMed

    Fleury, Heloisa J; Marra, Marlene M; Knobel, Anna M

    2015-10-01

    This paper describes the practice of sociodrama, a method created by J. L. Moreno in the 1930s, and the Brazilian contemporary socio-psychodrama. In 1970, after the Fifth International Congress of Psychodrama was held in Brazil, group psychotherapy began to flourish both in private practice and hospital clinical settings. Twenty years later, the Brazilian health care system added group work as a reimbursable mental health procedure to improve social health policies. In this context, socio-psychodrama became a key resource for social health promotion within groups. Some specific conceptual contributions by Brazilians on sociodrama are also noteworthy. PMID:26401805

  10. Photoheterotrophic growth of Agmenellum quadruplicatum PR-6

    SciTech Connect

    Lambert, D.H.; Stevens, S.E. Jr.

    1986-02-01

    The unicellular cyanobacterium Agmenellum quadruplicatum PR-6 grows in the presence of light on agar containing 10 ..mu..M 3-(3,4 dichlorophenyl)-1,1-dimethylurea and 1 to 30 mM glycerol. A derivative strain, PR-6G2, was tolerant of 100 mM glycerol. Photoheterotrophic growth conditions had little effect on transformation competence but did decrease the viability of single cells plated onto agar, particularly cells of the parent strain.

  11. PrEP: controversy, agency and ownership

    PubMed Central

    Cairns, Gus P; Race, Kane; Goicochea, Pedro

    2016-01-01

    Pre-exposure prophylaxis (PrEP) has been and continues to be an intervention that causes controversy and debate between stakeholders involved in providing or advocating for it, and within communities in need of it. These controversies extend beyond the intrinsically complex issues of making it available. In this commentary, some of the possible roots of the air of dissent and drama that accompanies PrEP are explored. The similarities between the controversies that dogged the earliest human trials of PrEP and the ones we see today in the era of licensing and implementation are explored. We outline five mediating principles or cultural norms that may influence arguments about PrEP differently. Three areas of specific concern are identified: medical risk versus benefit, distrust and fear of healthcare interventions, and fears for individual responsibility and community cohesion. The fear that PrEP may somehow represent a loss of control over one or more of these domains is suggested as an underlying factor. The development of countervailing measures, to institute greater community “ownership” of PrEP, and concomitant improvements in the sense of individual agency over sexual risk are outlined and recommended. PMID:27760689

  12. Geographic differences in the distribution of molecular subtypes of breast cancer in Brazil

    PubMed Central

    2014-01-01

    Background To compare the distribution of the intrinsic molecular subtypes of breast cancer based on immunohistochemical profile in the five major geographic regions of Brazil, a country of continental dimension, with a wide racial variation of people. Methods The study was retrospective observational. We classified 5,687 invasive breast cancers by molecular subtype based on immunohistochemical expression of estrogen-receptor (ER), progesterone-receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 proliferation index. Cases were classified as luminal A (ER and/or PR positive and HER2 negative, Ki-67 < 14%), luminal B (ER and/or PR positive, HER2 negative, and Ki-67 > 14%), triple-positive (ER and/or PR positive and HER2 positive), HER2-enriched (ER and PR negative, and HER2- positive), and triple-negative (TN) (ER negative, PR negative, and HER2- negative). Comparisons of the ages of patients and molecular subtypes between different geographic regions were performed. Results South and Southeast regions with a higher percentage of European ancestry and higher socioeconomic status presented with the highest proportion of luminal tumors. The North region presented with more aggressive subtypes (HER2-enriched and triple-negative), while the Central-West region predominated triple-positive carcinomas. The Northeast—a region with a high African influence—presented intermediate frequency of the different molecular subtypes. The differences persisted in subgroups of patients under and over 50 years. Conclusions The geographic regions differ according to the distribution of molecular subtypes of breast cancer. However, other differences, beside those related to African ancestry, such as socioeconomic, climatic, nutritional, and geographic, have to be considered to explain our results. The knowledge of the differences in breast cancer characteristics among the geographic regions may help to organize healthcare programs in large countries

  13. ESO PR Highlights in 2007

    NASA Astrophysics Data System (ADS)

    2008-01-01

    Another great year went by for ESO, the European Organisation for Astronomical Research in the Southern Hemisphere. From 1 January 2007, with the official joining of the Czech Republic, ESO has 13 member states, and since September, ESO has a new Director General, Tim de Zeeuw (ESO 03/07 and 38/07). Many scientific discoveries were made possible with ESO's telescopes. Arguably, the most important is the discovery of the first Earth-like planet in the habitable zone of a low-mass red dwarf (ESO 22/07). If there is water on this planet, then it should be liquid! ESO PR Highlights 2007 This is a clickable map. These are only some of the press releases issued by ESO in 2007. For a full listing, please go to ESO 2007 page. In our own Solar System also, astronomers made stunning breakthroughs with ESO's telescopes, observing the effect of the light from the Sun on an asteroid's rotation (ESO 11/07), describing in unprecedented detail the double asteroid Antiope (ESO 18/07), peering at the rings of Uranus (ESO 37/07), discovering a warm south pole on Neptune (ESO 41/07), showing a widespread and persistent morning drizzle of methane over the western foothills of Titan's major continent (ESO 47/07), and studying in the greatest details the wonderful Comet McNaught (ESO 05/07 and 07/07). In the study of objects slightly more massive than planets, the VLT found that brown dwarfs form in a similar manner to normal stars (ESO 24/07). The VLT made it also possible to measure the age of a fossil star that was clearly born at the dawn of time (ESO 23/07). Other discoveries included reconstructing the site of a flare on a solar-like star (ESO 53/07), catching a star smoking (ESO 34/07), revealing a reservoir of dust around an elderly star (ESO 43/07), uncovering a flat, nearly edge-on disc of silicates in the heart of the magnificent Ant Nebula (ESO 42/07), finding material around a star before it exploded (ESO 31/07), fingerprinting the Milky Way (ESO 15/07), revealing a rich

  14. Biothics in Brazil.

    PubMed

    Diniz, Debora; Guilhem, Dirce Bellezi; Garrafa, Volnei

    1999-07-01

    In this article the authors briefly sketch the nature of Brazilian bioethics. Bioethics emerged in Brazil later than in other Western countries and the 1990's were the most important period for the spread of the discipline in the country. It is in this period that some structural elements of bioethics were established, such as research groups, regulation of Local Research Ethics Committees (Comitês Locais de Etica em Pesquisa -- CEP), the creation of the National Commission of Ethics in Research with Human Beings (Comissão Nacional de Etica em Pesquisa com Seres Humanos -- CONEP) and the Brazilian Bioethics Society (Sociedade Brasileira de Bioética -- SBB). With regard to theoretical work, Brazilian bioethics is clearly an importer of theories from countries central to the studies of bioethics, or, in other words, countries where biothics first emerged and was established. The most commonly used theory among Brazilian researchers is principalism.

  15. The Brazil nut problem

    NASA Astrophysics Data System (ADS)

    Huerta, Dora; Ruiz-Suarez, Jesus

    2004-03-01

    The segregation of large intruders in a vertically vibrated granular bed is studied. We measure rising times a function of density, diameter and depth; for two different sinusoidal excitations. Our results shed definitive light to explain the fundamental aspects of the fascinating Brazil nut problem. At low frequencies (high amplitudes), inertia and convection are the only mechanisms behind segregation. Inertia dominates when the relative density of the intruder is greater than one and convection when it is less than one. At high frequencies (small amplitudes), where convection is suppressed, segregation occurs by buoyancy or sinkage. Finally, when the diameter of the intruders is changed, the well known paradigm "larger intruders rise faster" fails if the mass of the intruders is kept constant (while their relative densities are greater than one).

  16. Tungsten resources of Brazil

    USGS Publications Warehouse

    White, Max Gregg

    1974-01-01

    Brazilian tungsten production, 85 percent of which is exported, comes almost entirely from scheelite-bearing tactites in northeast Brazil, and has reached an annual rate of about 2,000 metric tons (2,200 short tons) of scheelite concentrate with 70 percent WO3. Scheelite ore reserves, located principally in the State of Rio Grande do Norte, are estimated to be as high as 8,300,000 tons (9,100,000 short tons) containing 0.7 percent WO3. Minor deposits (or those about which only minimal information is available) of wolframite, with which some cassiterite is associated, are located in Sao Paulo, Santa Catarina, and Rio Grande do Sul. Both the scheelite and the wolframite deposits are considered . to be late Precambrian A (620 to 900 m.y.) or early Cambrian in age.

  17. Brazil: public health genomics.

    PubMed

    Castilla, E E; Luquetti, D V

    2009-01-01

    Brazil represents half of South America and one third of Latin America, having more than 186 million inhabitants. After China and India it is the third largest developing country in the world. The wealth is unequally distributed among the states and among the people. Brazil has a large and complex health care system. A Universal Public Health System (SUS: Sistema SPACEnico de Saúde) covers the medical expenses for 80% of the population. The genetic structure of the population is very complex, including a large proportion of tri- hybrid persons, genetic isolates, and a panmictic large majority. Genetic services are offered at 64 genetic centers, half of them public and free. Nationwide networks are operating for inborn errors of metabolism, oncogenetics, and craniofacial anomalies. The Brazilian Society of Medical Genetics (SBGM) has granted 120 board certifications since 1986, and 7 recognized residences in medical genetics are operating in the country. Three main public health actions promoted by the federal government have been undertaken in the last decade, ultimately aimed at the prevention of birth defects. Since 1999, birth defects are reported for all 3 million annual live births, several vaccination strategies aim at the eradication of rubella, and wheat and maize flours are fortified with folic acid. Currently, the government distributes over 2 million US dollars to finance 14 research projects aimed at providing the basis for the adequate prevention and care of genetics disorders through the SUS. Continuity of this proactive attitude of the government in the area of genomics in public health is desired. PMID:19023184

  18. Zika: Why Brazil, Why Now

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_160251.html Zika: Why Brazil, Why Now Several factors -- including economics, ... been the country hit hardest by the ongoing Zika virus epidemic and its potential for birth defects. ...

  19. Correlation between Pr1 and Pr2 gene content and virulence in Metarhizium anisopliae strains.

    PubMed

    Rosas-García, Ninfa M; Avalos-de-León, Osvaldo; Villegas-Mendoza, Jesús M; Mireles-Martínez, Maribel; Barboza-Corona, J E; Castañeda-Ramírez, J C

    2014-11-28

    Metarhizium anisopliae is a widely studied model to understand the virulence factors that participate in pathogenicity. Proteases such as subtilisin-like enzymes (Pr1) and trypsin-like enzymes (Pr2) are considered important factors for insect cuticle degradation. In four M. anisopliae strains (798, 6342, 6345, and 6347), the presence of pr1 and pr2 genes, as well as the enzymatic activity of these genes, was correlated with their virulence against two different insect pests. The 11 pr1 genes (A, B, C, D, E, F, G, H, I, J, and K) and pr2 gene were found in all strains. The activity of individual Pr1 and Pr2 proteases exhibited variation in time (24, 48, 72, and 96 h) and in the presence or absence of chitin as the inductor. The highest Pr1 enzymatic activity was shown by strain 798 at 48 h with chitin. The highest Pr2 enzymatic activity was exhibited by the 6342 and 6347 strains, both grown with chitin at 24 and 48 h, respectively. Highest mortality on S. exigua was caused by strain 6342 at 48 h, and strains 6342, 6345, and 6347 caused the highest mortality 7 days later. Mortality on Prosapia reached 30% without variation. The presence of subtilisin and trypsin genes and the activity of these proteases in M. anisopliae strains cannot be associated with the virulence against the two insect pests. Probably, subtilisin and trypsin enzyme production is not a vital factor for pathogenicity, but its contribution is important to the pathogenicity process.

  20. Luminescence of Pr 3+ in minerals

    NASA Astrophysics Data System (ADS)

    Gaft, Michael; Reisfeld, Renata; Panczer, Gerard; Uspensky, Eugene; Varrel, Bernard; Boulon, Georges

    1999-10-01

    Time-resolved luminescence spectroscopy coupled with selective excitation allows one to identify and assign the emission transitions of Pr 3+ in natural apatite, scheelite and anhydrite. Under steady state conditions they are hidden by the stronger bands and lines of Eu 2+, (WO 4) 2-, (MoO 4) 2-, Sm 3+ and Dy 3+. Of special interest are the transitions from the 1S 0 level emitting in the UV part of the spectrum. These transitions make Pr 3+ doped oxyapatite and anhydrite potential materials for UV laser. The long-lived luminescence of Pr 3+ in the visible range in apatite in the presence of uranyl and in scheelite may be ascribed to the participation of the 1S 0 level which serves as a trap of the excitation.

  1. Agriculture, Rio Sao Francisco, Brazil

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This infrared scene of agriculture and ranching enterprises along the middle portion of the Rio Sao Francisco basin of Brazil (13.0S, 43.5 W) shows the usefulness of infrared film in determining types of vegetation. This region of Brazil has been under study for agriculture and ranching enterprises for several years. However, unpredictable rainfall and frequent severe droughts have limited the success of these enterprises.

  2. Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A2 from Bothrops pirajai venom

    PubMed Central

    2012-01-01

    Background Harpalycin 2 (HP-2) is an isoflavone isolated from the leaves of Harpalyce brasiliana Benth., a snakeroot found in northeast region of Brazil and used in folk medicine to treat snakebite. Its leaves are said to be anti-inflammatory. Secretory phospholipases A2 are important toxins found in snake venom and are structurally related to those found in inflammatory conditions in mammals, as in arthritis and atherosclerosis, and for this reason can be valuable tools for searching new anti-phospholipase A2 drugs. Methods HP-2 and piratoxin-III (PrTX-III) were purified through chromatographic techniques. The effect of HP-2 in the enzymatic activity of PrTX-III was carried out using 4-nitro-3-octanoyloxy-benzoic acid as the substrate. PrTX-III induced platelet aggregation was inhibited by HP-2 when compared to aristolochic acid and p-bromophenacyl bromide (p-BPB). In an attempt to elucidate how HP-2 interacts with PrTX-III, mass spectrometry, circular dichroism and intrinsic fluorescence analysis were performed. Docking scores of the ligands (HP-2, aristolochic acid and p-BPB) using PrTX-III as target were also calculated. Results HP-2 inhibited the enzymatic activity of PrTX-III (IC50 11.34 ± 0.28 μg/mL) although it did not form a stable chemical complex in the active site, since mass spectrometry measurements showed no difference between native (13,837.34 Da) and HP-2 treated PrTX-III (13,856.12 Da). A structural analysis of PrTX-III after treatment with HP-2 showed a decrease in dimerization and a slight protein unfolding. In the platelet aggregation assay, HP-2 previously incubated with PrTX-III inhibited the aggregation when compared with untreated protein. PrTX-III chemical treated with aristolochic acid and p-BPB, two standard PLA2 inhibitors, showed low inhibitory effects when compared with the HP-2 treatment. Docking scores corroborated these results, showing higher affinity of HP-2 for the PrTX-III target (PDB code: 1GMZ) than aristolochic

  3. Using PR Tools to Boost Recruitment.

    ERIC Educational Resources Information Center

    Rabbino, Irma L.

    1979-01-01

    Public relations and admissions are shown to be related. It is not necessary to use exotic PR tools to recruit students. Some suggestions include: the magic of marketing; national, local and hometown media; publications; filmstrips or cassettes; fairs and festivals; public service; and logo buttons, decals, etc. (MLW)

  4. Neotectonics in northeastern Brazil

    NASA Astrophysics Data System (ADS)

    Bezerra, Francisco Hilario Rego

    The thesis describes neotectonic deformation in the continental intraplate region of northeastern Brazil and explores its links with modern seismicity. The region, which is under E-W-oriented compression and N-S-oriented extension, shows shallow earthquake swarms which last for several years and include 5.0-5.2 mb events. Remote sensing, borehole and geophysical data, in conjunction with field structural information, indicate a continuous faulting process since the Miocene which has reactivated Cretaceous faults and Precambrian shear zones or in places generated new faults which cut across existing structures. Three main sets of faults are recognised across the area: a NE-striking set, a NW-striking set and a N-striking set. The first and the second sets are pervasive and their cross-cutting relationships show that they locally form a conjugate set and display both a strike-slip and a dip-slip component of movement. They have generated troughs filled by as much as 260 m of Cainozoic sediments. Radiocarbon dating shows that some of the faults slipped as recently as 4,041-3,689 cal. yr BP. Although the elevation of coastal deposits is consistent with the predictions of glacioisostatic models for the area, tectonic influence can be detected notably near the Carnaubais fault, where rapid emergence by at least 5 m to the east of Sao Bento occurred 4,080-2,780 cal. yr BP. Secondary ground failure, which includes hydroplastic deformation, liquefaction and landslides, can be seen in Quaternary alluvial sediments and is reported in the historical record. The present data show that the potential for large earthquakes in northeastern Brazil has been underestimated. Empirical relationships using liquefaction and surface rupture point to events of at least Ms=6.8 compared to a maximum mb = 5.2 recorded instrumentally. The finding that NE- and NW-trending faults are favourably orientated for reactivation in relation to the current stress field is of potential value for seismic

  5. [Epidemiological research in Brazil].

    PubMed

    Guimarães, R; Lourenço-De-Oliveira, R; Cosac, S

    2001-08-01

    The current epidemiological research in Brazil is described. Secondary data sources were consulted, such as the year 2000 database of the Brazilian Directory of Research Groups and the National Board of Scientific and Technological Development (CNPq). The criterion to identify a group as a research one relies on the existence of at least one research line in the field of epidemiology, as defined by the group leader. After identifying the defined universe of epidemiological research, which included 176 groups and 320 different research lines, the following issues were presented and discussed: the relationships between research financing and health research, focusing on CAPES (Coordination Center for the Advance of University Professionals) graduation programs, public health research and epidemiological research, geographic and institutional distribution and outreach of the current epidemiological research, the researchers and students directly participating in epidemiological research, research topics and patterns of disseminating research findings; the journals where papers in its fullness were published; the financial support of the epidemiological research focusing on the 23 officially recognized graduate programs in public health field. PMID:11600921

  6. Tin resources of Brazil

    USGS Publications Warehouse

    White, Max Gregg

    1974-01-01

    Annual tin production in Brazil, most of it from cassiterite placer deposits in Rondonia Territory, amounts to about 4,000 metric tons (4,400 short tons) of concentrate containing 66 percent tin, much of which is consumed by Brazilian industry. Reserves of cassiterite concentrate in the placers of Rondonia district are estimated at about 160,000 (176,000 short tons) containing 66 percent tin. Extensive undiscovered resources of cassiterite possibly exist in southern Rondonia Territory and to the east of the Territory in northern Mato Grosso, southern Amazonas, and southern Para. Numerous occurrences have been reported in these regions and as far to the east as the headwaters of the Tapajos and the Xingo Rivers. Minor deposits or occurrences of cassiterite (or lode deposits about which there is only minimal information available) are located in Para, Amapa, Paraiba, Rio Grande do Norte, Ceara, Bahia, Minas Gerais, Goias, Sao Paulo, and Rio Grande do Sul. All the lode tin deposits are dated or enclosed in rocks that date as Precambrian B (900 to 1,300 m.y.).

  7. Experimental investigation of the Cd-Pr phase diagram.

    PubMed

    Reichmann, Thomas L; Effenberger, Herta S; Ipser, Herbert

    2014-01-01

    The complete Cd-Pr equilibrium phase diagram was investigated with a combination of powder-XRD, SEM and DTA. All intermetallic compounds within this system, already reported in literature, could be confirmed: CdPr, Cd2Pr, Cd3Pr, Cd45Pr11, Cd58Pr13, Cd6Pr and Cd11Pr. The corresponding phase boundaries were determined at distinct temperatures. The homogeneity range of the high-temperature allotropic modification of Pr could be determined precisely and a limited solubility of 22.1 at.% Cd was derived. Additionally, single-crystal X-ray diffraction was employed to investigate structural details of Cd2Pr; it is isotypic to the AlB2-type structure with a z value of the Cd site of 0.5. DTA results of alloys located in the adjacent two-phase fields of Cd2Pr suggested a phase transformation between 893 and 930°C. For the phase Cd3Pr it was found that the lattice parameter a changes linearly with increasing Cd content, following Vegard's rule. The corresponding defect mechanism could be evaluated from structural data collected with single-crystal XRD. Introduction of a significant amount of vacancies on the Pr site and the reduction in symmetry of one Cd position (8c to 32f) resulted in a noticeable decrease of all R-values.

  8. Experimental Investigation of the Cd-Pr Phase Diagram

    PubMed Central

    Reichmann, Thomas L.; Effenberger, Herta S.; Ipser, Herbert

    2014-01-01

    The complete Cd-Pr equilibrium phase diagram was investigated with a combination of powder-XRD, SEM and DTA. All intermetallic compounds within this system, already reported in literature, could be confirmed: CdPr, Cd2Pr, Cd3Pr, Cd45Pr11, Cd58Pr13, Cd6Pr and Cd11Pr. The corresponding phase boundaries were determined at distinct temperatures. The homogeneity range of the high-temperature allotropic modification of Pr could be determined precisely and a limited solubility of 22.1 at.% Cd was derived. Additionally, single-crystal X-ray diffraction was employed to investigate structural details of Cd2Pr; it is isotypic to the AlB2-type structure with a z value of the Cd site of 0.5. DTA results of alloys located in the adjacent two-phase fields of Cd2Pr suggested a phase transformation between 893 and 930°C. For the phase Cd3Pr it was found that the lattice parameter a changes linearly with increasing Cd content, following Vegard’s rule. The corresponding defect mechanism could be evaluated from structural data collected with single-crystal XRD. Introduction of a significant amount of vacancies on the Pr site and the reduction in symmetry of one Cd position (8c to 32f) resulted in a noticeable decrease of all R-values. PMID:24718502

  9. Experimental investigation of the Cd-Pr phase diagram.

    PubMed

    Reichmann, Thomas L; Effenberger, Herta S; Ipser, Herbert

    2014-01-01

    The complete Cd-Pr equilibrium phase diagram was investigated with a combination of powder-XRD, SEM and DTA. All intermetallic compounds within this system, already reported in literature, could be confirmed: CdPr, Cd2Pr, Cd3Pr, Cd45Pr11, Cd58Pr13, Cd6Pr and Cd11Pr. The corresponding phase boundaries were determined at distinct temperatures. The homogeneity range of the high-temperature allotropic modification of Pr could be determined precisely and a limited solubility of 22.1 at.% Cd was derived. Additionally, single-crystal X-ray diffraction was employed to investigate structural details of Cd2Pr; it is isotypic to the AlB2-type structure with a z value of the Cd site of 0.5. DTA results of alloys located in the adjacent two-phase fields of Cd2Pr suggested a phase transformation between 893 and 930°C. For the phase Cd3Pr it was found that the lattice parameter a changes linearly with increasing Cd content, following Vegard's rule. The corresponding defect mechanism could be evaluated from structural data collected with single-crystal XRD. Introduction of a significant amount of vacancies on the Pr site and the reduction in symmetry of one Cd position (8c to 32f) resulted in a noticeable decrease of all R-values. PMID:24718502

  10. Isolation and characterization of Pr@C{sup 82} and Pr{sup 2}@C{sup 80}

    SciTech Connect

    Ding, J.; Yang, S.

    1996-11-13

    Pr@C{sup 82} and Pr{sup 2}@C{sup 80} have been isolated with a purity of >99.0% by an efficient solvent extraction procedure, followed by HPLC separation. UV-VIS-NIR spectra of the metallofullerenes were measured in the wavelength range from 300 to 2100 nm. The X-ray photoelectron spectra of Pr@C{sup 82} and Pr{sup 2}@C{sup 80} suggest that the Pr atoms inside the carbon cages all exist in a cationic form represented by Pr{sup 3+}. 32 refs., 5 figs.

  11. Hydrological Forecasting Practices in Brazil

    NASA Astrophysics Data System (ADS)

    Fan, Fernando; Paiva, Rodrigo; Collischonn, Walter; Ramos, Maria-Helena

    2016-04-01

    This work brings a review on current hydrological and flood forecasting practices in Brazil, including the main forecasts applications, the different kinds of techniques that are currently being employed and the institutions involved on forecasts generation. A brief overview of Brazil is provided, including aspects related to its geography, climate, hydrology and flood hazards. A general discussion about the Brazilian practices on hydrological short and medium range forecasting is presented. Detailed examples of some hydrological forecasting systems that are operational or in a research/pre-operational phase using the large scale hydrological model MGB-IPH are also presented. Finally, some suggestions are given about how the forecasting practices in Brazil can be understood nowadays, and what are the perspectives for the future.

  12. Paecilomyces niveus Stolk & Samson, 1971 (Ascomycota: Thermoascaceae) as a pathogen of Nasonovia ribisnigri (Mosley, 1841) (Hemiptera, Aphididae) in Brazil.

    PubMed

    Zawadneak, M A C; Pimentel, I C; Robl, D; Dalzoto, P; Vicente, V; Sosa-Gómez, D R; Porsani, M; Cuquel, F L

    2015-11-01

    Nasonovia ribisnigri is a key pest of lettuce (Lactuca sativa L.) in Brazil that requires alternative control methods to synthetic pesticides. We report, for the first time, the occurrence of Paecilomyces niveus as an entomopathogen of the aphid Nasonovia ribisnigri in Pinhais, Paraná, Brazil. Samples of mummified aphids were collected from lettuce crops. The fungus P. niveus (PaePR) was isolated from the insect bodies and identified by macro and micromorphology. The species was confirmed by sequencing Internal Transcribed Spacer (ITS) rDNA. We obtained a sequence of 528 bp (accession number HQ441751), which aligned with Byssochlamys nivea strains (100% identities). In a bioassay, 120 h after inoculation of N. ribisnigri with pathogenic P. niveus had an average mortality of 74%. The presence of P. niveus as a natural pathogen of N. ribisnigri in Brazil suggests that it may be possible to employ P. niveus to minimize the use of chemical insecticides.

  13. Paecilomyces niveus Stolk & Samson, 1971 (Ascomycota: Thermoascaceae) as a pathogen of Nasonovia ribisnigri (Mosley, 1841) (Hemiptera, Aphididae) in Brazil.

    PubMed

    Zawadneak, M A C; Pimentel, I C; Robl, D; Dalzoto, P; Vicente, V; Sosa-Gómez, D R; Porsani, M; Cuquel, F L

    2015-11-01

    Nasonovia ribisnigri is a key pest of lettuce (Lactuca sativa L.) in Brazil that requires alternative control methods to synthetic pesticides. We report, for the first time, the occurrence of Paecilomyces niveus as an entomopathogen of the aphid Nasonovia ribisnigri in Pinhais, Paraná, Brazil. Samples of mummified aphids were collected from lettuce crops. The fungus P. niveus (PaePR) was isolated from the insect bodies and identified by macro and micromorphology. The species was confirmed by sequencing Internal Transcribed Spacer (ITS) rDNA. We obtained a sequence of 528 bp (accession number HQ441751), which aligned with Byssochlamys nivea strains (100% identities). In a bioassay, 120 h after inoculation of N. ribisnigri with pathogenic P. niveus had an average mortality of 74%. The presence of P. niveus as a natural pathogen of N. ribisnigri in Brazil suggests that it may be possible to employ P. niveus to minimize the use of chemical insecticides. PMID:26602345

  14. Thunderstorms over Brazil

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This photograph, acquired in February 1984 by an astronaut aboard the space shuttle, shows a series of mature thunderstorms located near the Parana River in southern Brazil. With abundant warm temperatures and moisture-laden air in this part of Brazil, large thunderstorms are commonplace. A number of overshooting tops and anvil clouds are visible at the tops of the clouds. Storms of this magnitude can drop large amounts of rainfall in a short period of time, causing flash floods. However, a NASA-funded researcher has discovered that tiny airborne particles of pollution may modify developing thunderclouds by increasing the quantity and reducing the size of the ice crystals within them. These modifications may affect the clouds' impact on the Earth's 'radiation budget,' or the amount of radiation that enters and leaves our planet. Steven Sherwood, a professor at Yale University, found that airborne aerosols reduce the size of ice crystals in thunderclouds and may reduce precipitation as well. Using several satellites and instruments including NASA's Total Ozone Mapping Spectrometer (TOMS) and NASA's Tropical Rainfall Measuring Mission (TRMM) satellite, Sherwood observed how airborne pollution particles (aerosols) affect large thunderstorms, or cumulonimbus clouds in the tropics. Common aerosols include mineral dust, smoke, and sulfates. An increased number of these particles create a larger number of smaller ice crystals in cumulonimbus clouds. As a result of their smaller size, the ice crystals evaporate from a solid state directly into a gas, instead of falling as rain. Sherwood noted that this effect is more prevalent over land than open ocean areas. Previous research by Daniel Rosenfeld of Hebrew University revealed that aerosols and pollution reduced rainfall in shallow cumulus clouds of liquid water, which do not have the capability to produce as much rainfall. Sherwood expanded on that research by looking at cumulonimbus clouds with more ice particles. Studies

  15. Country watch: Brazil.

    PubMed

    Szterenfeld, C

    1995-01-01

    The Health in Prostitution Project was launched in 1991 in Rio de Janeiro, Brazil. The project offers a multi-year training program of health education designed to both fight the stigmatization of and violence against commercial sex workers and enhance their self-esteem, self-determination, and access to civil rights. The project therefore promotes individual awareness while influencing public opinion and policies. At first, health agents were recruited among women and transvestites who work in street-based sex work. The program was then gradually expanded to include young male sex workers and other locations, such as private parlors, saunas, and escort services. People of all sexes and sexual orientation now comprise the health agent group. The program has a paid staff of five women, three young men, and three transvestites, and approximately 70 sex workers are trained annually. Basic training includes topics such as human sexuality, personal risk assessment, HIV/STD infection, negotiation of safer sex, and STD referral services. Year two training emphasizes reproductive and women's health issues, while year three courses prioritize street work methodologies. Theatrical performances, speaking English as a second language, and performing Bach flower therapy for clients take place during the fourth year. Program trainers include medical specialists, nurses, psychologists, health educators, lawyers, and university students. At least half of the 350 health agents trained thus far are estimated to be currently engaged in paid or voluntary prevention work. Two surveys with female sex workers in 1991 and 1993 found that reported regular condom use increased from 57% to 73%; the health agents are having an effect. The program is constantly evaluated and revised.

  16. Sexuality education in Brazil.

    PubMed

    Suplicy, M

    1994-01-01

    The development of a comprehensive program of sex education in Brazilian schools is described in the context of Brazil's culture and traditions such as the Carnival. The influence of Catholicism is explored as is the effect of the behavioral restrictions called for by scientists concerned about sexually transmitted diseases. The Brazilian response to homosexuality is described, and the emergence of a public discussion of sexuality in the media is traced. It is noted that improvements in the status of women have been held in check by a public ridicule of feminism and by the strength of the traditional patriarchal structures which dominate the culture. With this picture given of how the issue of sexuality fits into Brazilian life, the 1980s initiative on the part of the Work and Research Group for Sex Education is described. Opposition to this effort has largely taken the form of passive resistance; even the Catholic Church has not officially protested the sex education program. Details are provided about 1) the selection of teachers, teacher training, and weekly supervisory teacher meetings; 2) the way in which parental permission for student participation was gained; 3) the implementation of the program; 4) the successes achieved; and 5) the difficulties encountered. Finally, it is noted that plans were made to expand the sex education project from the Sao Paulo area to 6 additional large cities in 1994. Also planned is the publication of the Brazilian Guidelines for Comprehensive Sexuality which will explain the sex education methodology and be extremely valuable in the establishment of new projects. PMID:12287356

  17. Country watch: Brazil.

    PubMed

    Szterenfeld, C

    1995-01-01

    The Health in Prostitution Project was launched in 1991 in Rio de Janeiro, Brazil. The project offers a multi-year training program of health education designed to both fight the stigmatization of and violence against commercial sex workers and enhance their self-esteem, self-determination, and access to civil rights. The project therefore promotes individual awareness while influencing public opinion and policies. At first, health agents were recruited among women and transvestites who work in street-based sex work. The program was then gradually expanded to include young male sex workers and other locations, such as private parlors, saunas, and escort services. People of all sexes and sexual orientation now comprise the health agent group. The program has a paid staff of five women, three young men, and three transvestites, and approximately 70 sex workers are trained annually. Basic training includes topics such as human sexuality, personal risk assessment, HIV/STD infection, negotiation of safer sex, and STD referral services. Year two training emphasizes reproductive and women's health issues, while year three courses prioritize street work methodologies. Theatrical performances, speaking English as a second language, and performing Bach flower therapy for clients take place during the fourth year. Program trainers include medical specialists, nurses, psychologists, health educators, lawyers, and university students. At least half of the 350 health agents trained thus far are estimated to be currently engaged in paid or voluntary prevention work. Two surveys with female sex workers in 1991 and 1993 found that reported regular condom use increased from 57% to 73%; the health agents are having an effect. The program is constantly evaluated and revised. PMID:12346918

  18. Zika virus outbreak in Brazil.

    PubMed

    Heukelbach, Jorg; Alencar, Carlos Henrique; Kelvin, Alyson Ann; de Oliveira, Wanderson Kleber; Pamplona de Góes Cavalcanti, Luciano

    2016-02-28

    Zika virus (ZIKV) infection is spreading rapidly within the Americas after originating from an outbreak in Brazil. We describe the current ZIKV infection epidemic in Brazil and the neurological symptoms arising. First cases of an acute exanthematic disease were reported in Brazil's Northeast region at the end of 2014. In March 2015, autochthonous ZIKV was determined to be the causative agent of the exanthematic disease. As cases of neurological syndromes in regions where ZIKV, dengue and/or Chikungunya viruses co-circulate were reported, ZIKV was also identified in the cerebrospinal fluid of patients with acute neurological syndromes and previous exanthematic disease. By the end of September 2015, an increasing number of infants with small head circumference or microcephaly were noted in Brazil's Northeast which was estimated to be 29 cases between August and October. ZIKV was identified in blood and tissue samples of a newborn and in mothers who had given birth to infants with microcephaly and ophthalmological anomalies. In 2015, there were an estimated 440,000 - 1,300,000 Zika cases in Brazil. There have been 4,783 suspected cases of microcephaly, most of them in the Northeast of Brazil associated with 76 deaths. The Ministry of Health is intensifying control measures against the mosquito Aedes aegypti and implemented intensive surveillance actions. Further studies are needed to confirm the suspected association between ZIKV infection and microcephaly; to identify antiviral, immunotherapy, or prophylactic vaccine; to introduce diagnostic ELISA testing. Clinical and epidemiological studies must be performed to describe viral dynamics and expansion of the outbreak.

  19. Electron Paramagnetic Resonance Study of Pr

    SciTech Connect

    Tezuka, Keitaro; Hinatsu, Yukio

    2001-01-01

    Electron paramagnetic resonance (EPR) spectra of tetravalent praseodymium ions doped in the cubic perovskite compound BaHfO{sub 3} have been measured at 4.2 K. A very large hyperfine interaction with the {sup 141}Pr nucleus was observed in the spectrum of Pr{sup 4+}/ BaHfO{sub 3}. The results were analyzed based on the weak field approximation, and the g value (|g|=0.619) and a hyperfine coupling constant (A=0.0589 cm{sup {minus}1}) were obtained. The measured g value is much smaller than |-10/7|, which indicates that the crystal field effect on the behavior of a 4f electron is large. These g and A values were compared with the EPR results for other f{sup 1} ions in an octahedral crystal field.

  20. Brazil The Duck Lagoon

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This Multi-angle Imaging SpectroRadiometer (MISR) image of Brazil covers an area of about 298 kilometers x 358 kilometers, and was captured by the instrument's vertical-viewing (nadir) camera on December 27, 2001. The 'Lagoa dos Patos', in the Brazilian state of Rio Grande do Sul, translates to 'the Duck Lagoon'. It was named by 16th century Jesuit settlers, who asked the King of Spain to grant them title to the lagoon so that they could breed ducks. The King consented, but revoked his edict when he discovered that the 'duck-pond' (measuring about 14,000 square kilometers) was one of the largest lagoonal systems in the world. Note the sediment plume emanating from the southern end of the lagoon. Sailors in the 16th century imagined this outlet to be the mouth of a large river. Early Portuguese explorers mistook the entrance to the lagoon for the mouth of a great river and called it the Rio Grande. A series of wave-like points and curls form 'cusps' on the inner shores of the lagoon. The lagoon's characteristics change with short-term tide-induced cyclic perturbations, and with longer term large scale meteorological conditions. The distinctive wavelike 'cusps' along the inner shores result from the circulation, erosion and accumulation of sediments driven by wind and tidal action. The El Nino Southern Oscillation (ENSO) circulation affects precipitation amount and continental runoff, thereby changing the contents of the lagoon waters. High rainfall and increased freshwater discharge during El Nino events correspond with elevated dissolved nutrient concentrations and increased phytoplankton growth. La Nina years are dry and the associated low rainfall reduces the freshwater recharge to the lagoon, causing an increase in salinity. Occasional blooms of toxic cyanobacteria (Microcystis aeruginosa), have been registered in the lagoon when nutrient concentrations are elevated. A number of reeds and grasses are important to the lagoon estuary, including widgeon grass

  1. S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness

    PubMed Central

    Chavez, Alejandra; Schmidt, Tracy Thennes; Yazbeck, Pascal; Rajput, Charu; Desai, Bhushan; Sukriti, Sukriti; Giantsos-Adams, Kristina; Knezevic, Nebojsa; Malik, Asrar B.; Mehta, Dolly

    2015-01-01

    ABSTRACT Activation of sphingosine-1-phosphate receptor 1 (S1PR1) plays a key role in repairing endothelial barrier function. We addressed the role of phosphorylation of the three intracellular tyrosine residues of S1PR1 in endothelial cells in regulating the receptor responsiveness and endothelial barrier function regulated by sphingosine 1-phosphate (S1P)-mediated activation of S1PR1. We demonstrated that phosphorylation of only Y143 site was required for S1PR1 internalization in response to S1P. Maximal S1PR1 internalization was seen in 20 min but S1PR1 returned to the cell surface within 1 h accompanied by Y143-dephosphorylation. Cell surface S1PR1 loss paralleled defective endothelial barrier enhancement induced by S1P. Expression of phospho-defective (Y143F) or phospho-mimicking (Y143D) mutants, respectively, failed to internalize or showed unusually high receptor internalization, consistent with the requirement of Y143 in regulating cell surface S1PR1 expression. Phosphorylation of the five S1PR1 C-terminal serine residues did not affect the role of Y143 phosphorylation in signaling S1PR1 internalization. Thus, rapid reduction of endothelial cell surface expression of S1PR1 subsequent to Y143 phosphorylation is a crucial mechanism of modulating S1PR1 signaling, and hence the endothelial barrier repair function of S1P. PMID:25588843

  2. Opportunity Foregone: Education in Brazil.

    ERIC Educational Resources Information Center

    Birdsall, Nancy, Ed.; Sabot, Richard H., Ed.

    The studies presented in this volume help readers to understand the constraints faced in addressing the key problems within the Brazilian education system. Steps to address the issues and benefits to be gained by addressing those issues are discussed. Forty-two authors reiterate that the success of Brazil's education reform will have an important…

  3. Environmental Education Activities in Brazil.

    ERIC Educational Resources Information Center

    Sato, Michele

    1994-01-01

    Describes environmental education activities in the Cuiaba region of Brazil's Amazon and Platina Basins. Activities include the environmental education specialization course at the Federal University of Mato Grosso, teacher training in rural schools, and the introduction of environmental themes into school curriculum. (MDH)

  4. Chromobacterium violaceum in Siblings, Brazil

    PubMed Central

    Dias, Juarez; Ruf, Hilda; Ramos, Eduardo Antonio G.; Maciel, Elves Anderson Pires; Rolim, Ana; Jabur, Laura; Vasconcelos, Luciana; Silvany, Célia

    2005-01-01

    Chromobacterium violaceum, a saprophyte bacterium found commonly in soil and water in tropical and subtropical climates, is a rare cause of severe, often fatal, human disease. We report 1 confirmed and 2 suspected cases of C. violaceum septicemia, with 2 fatalities, in siblings after recreational exposure in northeastern Brazil. PMID:16229777

  5. Chromobacterium violaceum in siblings, Brazil.

    PubMed

    de Siqueira, Isadora Cristina; Dias, Juarez; Ruf, Hilda; Ramos, Eduardo Antonio G; Maciel, Elves Anderson Pires; Rolim, Ana; Labur, Laura; Vasconcelos, Luciana; Silvany, Célia

    2005-09-01

    Chromobacterium violaceum, a saprophyte bacterium found commonly in soil and water in tropical and subtropical climates, is a rare cause of severe, often fatal, human disease. We report 1 confirmed and 2 suspected cases of C. violaceum septicemia, with 2 fatalities, in siblings after recreational exposure in northeastern Brazil. PMID:16229777

  6. Brazil soybean yield covariance model

    NASA Technical Reports Server (NTRS)

    Callis, S. L.; Sakamoto, C.

    1984-01-01

    A model based on multiple regression was developed to estimate soybean yields for the seven soybean-growing states of Brazil. The meteorological data of these seven states were pooled and the years 1975 to 1980 were used to model since there was no technological trend in the yields during these years. Predictor variables were derived from monthly total precipitation and monthly average temperature.

  7. Neglected tropical diseases in Brazil.

    PubMed

    Lindoso, José Angelo L; Lindoso, Ana Angélica B P

    2009-01-01

    Poverty is intrinsically related to the incidence of Neglected Tropical Diseases (NTDs). The main countries that have the lowest human development indices (HDI) and the highest burdens of NTDs are located in tropical and subtropical regions of the world. Among these countries is Brazil, which is ranked 70th in HDI. Nine out of the ten NTDs established by the World Health Organization (WHO) are present in Brazil. Leishmaniasis, tuberculosis, dengue fever and leprosy are present over almost the entire Brazilian territory. More than 90% of malaria cases occur in the Northern region of the country, and lymphatic filariasis and onchocerciasis occur in outbreaks in a particular region. The North and Northeast regions of Brazil have the lowest HDIs and the highest rates of NTDs. These diseases are considered neglected because there is not important investment in projects for the development of new drugs and vaccines and existing programs to control these diseases are not sufficient. Another problem related to NTDs is co-infection with HIV, which favors the occurrence of severe clinical manifestations and therapeutic failure. In this article, we describe the status of the main NTDs currently occurring in Brazil and relate them to the HDI and poverty.

  8. Education for Librarianship in Brazil.

    ERIC Educational Resources Information Center

    Howard, Pamela F.

    The paper examines and describes the development, trends, and current status of education for librarianship in Brazil against the background of the contemporary library scene and the system of higher education in general, focusing on the development of the 30 undergraduate and six post-graduate library programs in existence today. The master's…

  9. Evaluating School Facilities in Brazil

    ERIC Educational Resources Information Center

    Ornstein, Sheila Walbe; Moreira, Nanci Saraiva

    2008-01-01

    Brazil's Sao Paulo Metropolitan Region is conducting a performance evaluation pilot study at three schools serving disadvantaged populations. The objective is first to test methods which can facilitate Post Occupancy Evaluations (POEs) and then to carry out the evaluations. The preliminary results are provided below.

  10. PrPC from stem cells to cancer

    PubMed Central

    Martin-Lannerée, Séverine; Hirsch, Théo Z.; Hernandez-Rapp, Julia; Halliez, Sophie; Vilotte, Jean-Luc; Launay, Jean-Marie; Mouillet-Richard, Sophie

    2014-01-01

    The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knockout animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumors. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumor-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression. PMID:25364760

  11. Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake

    PubMed Central

    Wolf, Hanna; Graßmann, Andrea; Bester, Romina; Hossinger, André; Möhl, Christoph; Paulsen, Lydia; Groschup, Martin H.; Schätzl, Hermann

    2015-01-01

    ABSTRACT Mammalian prions are unconventional infectious agents composed primarily of the misfolded aggregated host prion protein PrP, termed PrPSc. Prions propagate by the recruitment and conformational conversion of cellular prion protein into abnormal prion aggregates on the cell surface or along the endocytic pathway. Cellular glycosaminoglycans have been implicated as the first attachment sites for prions and cofactors for cellular prion replication. Glycosaminoglycan mimetics and obstruction of glycosaminoglycan sulfation affect prion replication, but the inhibitory effects on different strains and different stages of the cell infection have not been thoroughly addressed. We examined the effects of a glycosaminoglycan mimetic and undersulfation on cellular prion protein metabolism, prion uptake, and the establishment of productive infections in L929 cells by two mouse-adapted prion strains. Surprisingly, both treatments reduced endogenous sulfated glycosaminoglycans but had divergent effects on cellular PrP levels. Chemical or genetic manipulation of glycosaminoglycans did not prevent PrPSc uptake, arguing against their roles as essential prion attachment sites. However, both treatments effectively antagonized de novo prion infection independently of the prion strain and reduced PrPSc formation in chronically infected cells. Our results demonstrate that sulfated glycosaminoglycans are dispensable for prion internalization but play a pivotal role in persistently maintained PrPSc formation independent of the prion strain. IMPORTANCE Recently, glycosaminoglycans (GAGs) became the focus of neurodegenerative disease research as general attachment sites for cell invasion by pathogenic protein aggregates. GAGs influence amyloid formation in vitro. GAGs are also found in intra- and extracellular amyloid deposits. In light of the essential role GAGs play in proteinopathies, understanding the effects of GAGs on protein aggregation and aggregate dissemination is crucial

  12. Mitochondrial DNA polymorphism among populations of Melipona quadrifasciata quadrifasciata Lepeletier (Apidae: Meliponini) from southern Brazil.

    PubMed

    Torres, Rogelio R; Arias, Maria C; Moretto, Geraldo

    2009-01-01

    The geographical distribution of the Brazilian endemic stingless bee Melipona quadrifasciata quadrifasciata Lepeletier ranges from Rio Grande do Sul to Minas Gerais states. The objective of the present study was to verify mtDNA polymorphisms among samples of M. q. quadrifasciata collected in southern Brazil. Twenty nine colonies from three localities (Blumenau and Mafra/SC and Prudentópolis/ PR) were sampled. Seven mtDNA regions were amplified and further digested with 15 restriction enzymes (PCR-RFLP). Five composite haplotypes were identified, with two unique to samples from Prudentópolis and the remaining three to samples from Mafra and/or Blumenau. PMID:19488509

  13. Photoelectron spectrum of PrO-

    NASA Astrophysics Data System (ADS)

    Kafader, Jared O.; Ray, Manisha; Jarrold, Caroline Chick

    2015-08-01

    The photoelectron (PE) spectrum of PrO- exhibits a short 835 ± 20 cm-1 vibrational progression of doublets (210 ± 30 cm-1 splitting) assigned to transitions from the 4f2 [3H4] σ6s2 Ω = 4 anion ground state to the 4f2 [3H4] σ6s Ω = 3.5 and 4.5 neutral states. This assignment is analogous to that of the recently reported PE spectrum of CeO-, though the 82 cm-1 splitting between the 4f [2F2.5] σ6s Ω = 2 and Ω = 3 CeO neutral states could not be resolved [Ray et al., J. Chem. Phys. 142, 064305 (2015)]. The origin of the transition to the Ω = 3.5 neutral ground state is 0.96 ± 0.01 eV, which is the adiabatic electron affinity of PrO. Density functional theory calculations on the anion and neutral molecules support the assignment. The appearance of multiple, irregularly spaced and low-intensity features observed ca. 1 eV above the ground state cannot be reconciled with low-lying electronic states of PrO that are accessible via one-electron detachment. However, neutral states correlated with the 4f2 [3H4] 5d superconfiguration are predicted to be approximately 1 eV above the 4f2 [3H4] σ6s Ω = 3.5 neutral ground state, leading to the assignment of these features to shake-up transitions to the excited neutral states. Based on tentative hot band transition assignments, the term energy of the previously unobserved 4f2 [3H4] σ6s Ω = 2.5 neutral state is determined to be 1840 ± 110 cm-1.

  14. Effect of low ionic strength on anti-Pr reactions.

    PubMed

    Leo, A; Kreft, H; Hack, H; Roelcke, D

    1996-01-01

    The effect of low ionic strength (LIS) on 28 anti-Pr, 20 anti-I and 20 anti-i cold agglutinins was investigated. The reaction of the anti-Pr CAs varies markedly. In most cases LIS has an enhancing effect. In some cases the thermal amplitude was widened so far that the reaction at 37 degrees C under LIS was stronger than at 0 degree C in PBS. With regard to the anti-Pr subspecificities anti Pr1, -Pr2 and -Pr3 or to the distinction of the immunodominant NeuNAc group (alpha a2,6- or alpha 2,3-bond) a correlation between these characteristics and the reaction in LIS could not be identified. The anti-I are not influenced by LISS, anti-i in a few cases. The reason for the variable reaction of the anti-Pr remains unclear. To further elucidate the LISS effect on anti-Pr, the contribution of the antibody structure should be regarded, but data for the use of H- and L-chain genes in anti-Pr are sparse. For compatibility testing in the routine laboratory, LISS-sensitive anti-Pr may play a role in disturbing the screening for RBC antibodies.

  15. Lacustrine records of Holocene flood pulse dynamics in the Upper Paraguay River watershed (Pantanal wetlands, Brazil)

    NASA Astrophysics Data System (ADS)

    McGlue, Michael M.; Silva, Aguinaldo; Zani, Hiran; Corradini, Fabrício A.; Parolin, Mauro; Abel, Erin J.; Cohen, Andrew S.; Assine, Mario L.; Ellis, Geoffrey S.; Trees, Mark A.; Kuerten, Sidney; Gradella, Frederico dos Santos; Rasbold, Giliane Gessica

    2012-09-01

    The Pantanal is the world's largest tropical wetland and a biodiversity hotspot, yet its response to Quaternary environmental change is unclear. To address this problem, sediment cores from shallow lakes connected to the Upper Paraguay River (PR) were analyzed and radiocarbon dated to track changes in sedimentary environments. Stratal relations, detrital particle size, multiple biogeochemical indicators, and sponge spicules suggest fluctuating lake-level lowstand conditions between ~ 11,000 and 5300 cal yr BP, punctuated by sporadic and in some cases erosive flood flows. A hiatus has been recorded from ~ 5300 to 2600 cal yr BP, spurred by confinement of the PR within its channel during an episode of profound regional drought. Sustained PR flooding caused a transgression after ~ 2600 cal yr BP, with lake-level highstand conditions appearing during the Little Ice Age. Holocene PR flood pulse dynamics are best explained by variability in effective precipitation, likely driven by insolation and tropical sea-surface temperature gradients. Our results provide novel support for hypotheses on: (1) stratigraphic discontinuity of floodplain sedimentary archives; (2) late Holocene methane flux from Southern Hemisphere wetlands; and (3) pre-colonial indigenous ceramics traditions in western Brazil.

  16. Lacustrine records of Holocene flood pulse dynamics in the Upper Paraguay River watershed (Pantanal wetlands, Brazil)

    USGS Publications Warehouse

    McGlue, Michael M.; Silva, Aquinaldo; Zani, Hiran; Corradini, Fabricio A.; Parolin, Mauro; Abel, Erin J.; Cohen, Andrew S.; Assine, Mario L.; Ellis, Geoffrey S.; Trees, Mark A.; Kuerten, Sidney; Gradella, Frederico dos Santos; Rasbold, Giliane Gessica

    2012-01-01

    The Pantanal is the world's largest tropical wetland and a biodiversity hotspot, yet its response to Quaternary environmental change is unclear. To address this problem, sediment cores from shallow lakes connected to the UpperParaguayRiver (PR) were analyzed and radiocarbon dated to track changes in sedimentary environments. Stratal relations, detrital particle size, multiple biogeochemical indicators, and sponge spicules suggest fluctuating lake-level lowstand conditions between ~ 11,000 and 5300 cal yr BP, punctuated by sporadic and in some cases erosive flood flows. A hiatus has been recorded from ~ 5300 to 2600 cal yr BP, spurred by confinement of the PR within its channel during an episode of profound regional drought. Sustained PR flooding caused a transgression after ~ 2600 cal yr BP, with lake-level highstand conditions appearing during the Little Ice Age. Holocene PR floodpulsedynamics are best explained by variability in effective precipitation, likely driven by insolation and tropical sea-surface temperature gradients. Our results provide novel support for hypotheses on: (1) stratigraphic discontinuity of floodplain sedimentary archives; (2) late Holocene methane flux from Southern Hemisphere wetlands; and (3) pre-colonial indigenous ceramics traditions in western Brazil.

  17. HIV type 1 molecular epidemiology in pol and gp41 genes among naive patients from Mato Grosso do Sul State, central western Brazil.

    PubMed

    da Silveira, Alexsander Augusto; Cardoso, Ludimila Paula Vaz; Francisco, Roberta Barbosa Lopes; de Araújo Stefani, Mariane Martins

    2012-03-01

    Antiretroviral naive patients (n=49) were recruited in central western Brazil (Campo Grande City/Mato Grosso do Sul State, located across the Bolivia and Paraguay borders). HIV-1 protease (PR), reverse transcriptase (RT), and env gp41 HR1 fragments were sequenced. Genetic diversity was analyzed by REGA/phylogenetic analyses. Intersubtype recombinants were identified by SimPlot/phylogenetic trees. PR/RT resistance was analyzed by Calibrated Population Resistance/Stanford databases. T-20 resistance in gp41 was assessed by Stanford, Los Alamos, and other sources. Of HIV-1 subtypes 65.3% were B(PR)B(RT), 10.2% were C(PR)C(RT), and 8.2% were F1(PR)F1(RT). Intersubtype recombinants were 16.3%: four B/F1 and four B/C (two were "CRF31_BC-like"). The Pol-RT V75M mutation was detected in two homosexual partners; one patient had the T215S revertant mutation. T-20/gp41 resistance mutations were L44M (n=2) and V38A (n=1). The high percentage of non-B isolates (∼35%) highlights the importance of molecular surveillance studies in settings distant from the origin of the epidemic. Our data help elaborate the molecular epidemiological map of HIV-1 in Brazil.

  18. The PR in PN for Education Associations. PR Bookshelf, No. 3.

    ERIC Educational Resources Information Center

    National Education Association, Washington, DC.

    This booklet presents suggestions and guidelines for the effective use of public relations (PR) techniques during professional negotiations (PN) among teachers, administrators, and boards of education. Introductory sections present the National Education Association (NEA) position regarding professional negotiation and grievance procedures and…

  19. Brazil wheat yield covariance model

    NASA Technical Reports Server (NTRS)

    Callis, S. L.; Sakamoto, C.

    1984-01-01

    A model based on multiple regression was developed to estimate wheat yields for the wheat growing states of Rio Grande do Sul, Parana, and Santa Catarina in Brazil. The meteorological data of these three states were pooled and the years 1972 to 1979 were used to develop the model since there was no technological trend in the yields during these years. Predictor variables were derived from monthly total precipitation, average monthly mean temperature, and average monthly maximum temperature.

  20. Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

    PubMed Central

    Sakudo, Akikazu; Onodera, Takashi

    2015-01-01

    Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp−/−) mice. So far, six types of Prnp−/− mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not fully reveal PrP functions. Recently, varieties of Prnp−/− cell lines established from Prnp−/− mice have contributed to the analysis of PrP functions. In this mini-review, we focus on Prnp−/− cell lines and summarize currently available Prnp−/− cell lines and their characterizations. In addition, we introduce the recent advances in the methodology of cell line generation with knockout or knockdown of the PrP gene. We also discuss how these cell lines have provided valuable insights into PrP functions and show future perspectives. PMID:25642423

  1. Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice

    PubMed Central

    Salaga, M; Polepally, P R; Zielinska, M; Marynowski, M; Fabisiak, A; Murawska, N; Sobczak, K; Sacharczuk, M; Do Rego, J C; Roth, B L; Zjawiony, J K; Fichna, J

    2015-01-01

    Background and Purpose The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice. Experimental Approach To examine the antiscratch effect of PR-37 and PR-38 we used a mouse model of compound 48/80-induced pruritus. In order to elucidate the mechanism of action of tested compounds, specific antagonists of opioid and cannabinoid receptors were used. The effect of PR-37 on the CNS was assessed by measuring motor parameters and exploratory behaviours in mice. Key Results PR-37 and PR-38, jnjected s.c., significantly reduced the number of compound 48/80-induced scratching behaviours in mice in a dose- and time-dependent manner. PR-38 was also active when orally administered. The antiscratch activity of PR-37 was blocked by the selective κ opioid receptor antagonist, nor-binaltorphimine, and that of PR-38 by the selective μ opioid receptor antagonist, β-funaltrexamine. Conclusion and Implications In conclusion, a novel framework for the development of new antipruritic drugs derived from salvinorin A has been validated. PMID:26040667

  2. An AIDS campaign in Brazil.

    PubMed

    Janoff, D

    1987-01-01

    The Acquired Immune Deficiency Syndrome (AIDS) distribution program in Brazil, spearheaded by the National Division of Sanitary Surveillance in Ports, Airports, and Borders, was part of the government's massive education campaign to prevent the transmission of HIV-AIDS in Brazil. Beginning in February 1987, the climate was sufficiently favorable to operate a coordinated information campaign during the Carnival celebration, and tourists arriving in the cities of Brazil for the annual Carnival celebration were handed an educational brochure in Portugese, Spanish, English, and French. Yet, beyond reaching the tourist populations, it is particularly important to reach large portions of the Brazilian population. Planners of the national AIDS campaign intend to use television, radio, and all major newspapers in their effort to cover the country. Initial television coverage is comprised of short informational messages directed at high-risk groups. There also are plans to use radio and the print media in order to reach a wider audience. It is estimated that US $6 million will be needed to adequately meet the costs of AIDS prevention and medical care, but due to extreme budget constraints, only $45,000 has been earmarked for ongoing AIDS activities at this time. PMID:12281284

  3. AIDS Treatment In Brazil: Impacts And Challenges

    PubMed Central

    Nunn, Amy Stewart; Fonseca, Elize Massard da; Bastos, Francisco I.; Gruskin, Sofia

    2009-01-01

    Brazil has one of the developing world's largest, and arguably most successful, AIDS treatment programs. In this paper we review the treatment program, including controversial policies that Brazil has used to promote widespread local and global access to AIDS treatment. We also examine the lessons learned from this program and highlight the challenges Brazil faces, including the rising costs of AIDS treatment and changes in donors' funding priorities. Finally, we explore the relevance of Brazil's treatment program for other countries and its broad implications for global AIDS and health policy. PMID:19597210

  4. Prion propagation in cells expressing PrP glycosylation mutants.

    PubMed

    Salamat, Muhammad K; Dron, Michel; Chapuis, Jérôme; Langevin, Christelle; Laude, Hubert

    2011-04-01

    Infection by prions involves conversion of a host-encoded cell surface protein (PrP(C)) to a disease-related isoform (PrP(Sc)). PrP(C) carries two glycosylation sites variably occupied by complex N-glycans, which have been suggested by previous studies to influence the susceptibility to these diseases and to determine characteristics of prion strains. We used the Rov cell system, which is susceptible to sheep prions, to generate a series of PrP(C) glycosylation mutants with mutations at one or both attachment sites. We examined their subcellular trafficking and ability to convert into PrP(Sc) and to sustain stable prion propagation in the absence of wild-type PrP. The susceptibility to infection of mutants monoglycosylated at either site differed dramatically depending on the amino acid substitution. Aglycosylated double mutants showed overaccumulation in the Golgi compartment and failed to be infected. Introduction of an ectopic glycosylation site near the N terminus fully restored cell surface expression of PrP but not convertibility into PrP(Sc), while PrP(C) with three glycosylation sites conferred cell permissiveness to infection similarly to the wild type. In contrast, predominantly aglycosylated molecules with nonmutated N-glycosylation sequons, produced in cells expressing glycosylphosphatidylinositol-anchorless PrP(C), were able to form infectious PrP(Sc). Together our findings suggest that glycosylation is important for efficient trafficking of anchored PrP to the cell surface and sustained prion propagation. However, properly trafficked glycosylation mutants were not necessarily prone to conversion, thus making it difficult in such studies to discern whether the amino acid changes or glycan chain removal most influences the permissiveness to prion infection. PMID:21248032

  5. High spin states in /sup 137/Pr

    SciTech Connect

    Xu, N.; Beausang, C.W.; Ma, R.; Paul, E.S.; Piel W.F. Jr.; Fossan, D.B.; Hildingsson, L.

    1989-05-01

    The level structure of the /sup 137/Pr nucleus has been investigated via in-beam ..gamma..-ray spectroscopy using an 81-MeV /sup 122/Sn(/sup 19/F, 4n) reaction. A strongly populated positive-parity band was observed based on a proton orbital with (..pi..,..cap alpha..) = (+, + 1/2); its first backbend, due to the alignment of a pair of h/sub 11/2/ protons, was seen at a rotational frequency (h/2..pi..)..omega.. = 0.34 MeV. Such a high crossing frequency is taken as evidence for a triaxial shape (..gamma../similar to/30/sup 0/) for the ground-state band of /sup 137/Pr. Above the crossing, both signatures (..pi..,..cap alpha..) = +, +- (1/2) were observed up to I/sup ..pi../ = 37/2/sup +/ and 43/2/sup +/ (for ..cap alpha.. = +1/2 and ..cap alpha.. = -1/2), respectively. A negative-parity band, based on an h/sub 11/2/ proton orbital, was also observed showing a blocked h/sub 11/2/ proton crossing frequency of h/2..pi omega.. = 0.44 MeV. In addition, a ..delta..I = 1 band with strong M1 transitions and a small signature splitting was observed, which is believed to be based on the ..pi..h/sub 11/2/x(..nu..h/sub 11/2/)/sup 2/ configuration. The alignment of the h/sub 11/2/ neutron pair drives the nuclear core towards ..gamma.. = -60/sup 0/, namely, the collective oblate shape, while the alignment of the h/sub 11/2/ proton pair drives the nuclear core towards ..gamma.. = 0/sup 0/, the collective prolate shape. These results are consistent with cranked shell model calculations.

  6. Age, baseline kidney function, and medication exposure are associated with declines in creatinine clearance on PrEP: an observational cohort study

    PubMed Central

    Glidden, David; Mayer, Kenneth; Schechter, Mauro; Buchbinder, Susan; Grinsztejn, Beatriz; Hosek, Sybil; Casapia, Martin; Guanira, Juan; Bekker, Linda-Gail; Louie, Alexander; Horng, Howard; Benet, Leslie Z.; Liu, Albert; Grant, Robert

    2016-01-01

    SUMMARY Background As pre-exposure prophylaxis (PrEP) with tenofovir-disoproxil-fumarate/emtricitabine (TDF/FTC) for the prevention of HIV infection enters a phase of global roll-out, strategies to maintain effectiveness, but minimize adverse effects, merit close consideration. The aim of this study was to evaluate rates and predictors of renal toxicity in a large open-label study of PrEP to help provide guidance on safety monitoring with this important prevention strategy. Methods The iPrEx open-label-extension (OLE) study (NCT00458393) enrolled HIV-negative MSM/transgender participants from three previous PrEP trials from Brazil, Ecuador, Peru, South Africa, Thailand, and the U.S into an open-label PrEP study. There were no restrictions on current renal function for enrollment into iPrEx OLE.. Creatinine clearance (CrCl) on PrEP was estimated every 12 weeks and in a subset, hair samples were collected for measuring tenofovir (TFV)/FTC concentrations via liquid-chromatography/tandem-mass-spectrometry. Change in CrCl from baseline was calculated and predictors identified. Findings Baseline characteristics of participants in iPrEx-OLE (n=1224; 7475 person-visits) and its hair substudy (n=220; 1114 person-visits) were similar. Over 72 weeks (median), the average decline in CrCl was −2·9% (p<0.0001), but declines were significantly greater for those starting PrEP at older ages (−4·2% (95% CI −2·8%, −5·5%), baseline age 40–50 years; −4·9% (−3·1%, −6·8%), age ≥50). Besides age, baseline CrCl of <90ml/min in multivariate models predicted renal decline. There was a monotonic relationship between percent decrease in CrCl and number of doses of TDF/FTC taken per week as estimated by hair levels (p 0.008). Interpretation With the global roll-out of PrEP, our analysis suggests that the frequency of safety monitoring may differ by age group and that pharmacologic measures of adherence can additionally monitor for toxicities. Funding NIH PMID:27658870

  7. Self-reported Recent PrEP Dosing and Drug Detection in an Open Label PrEP Study.

    PubMed

    Amico, K Rivet; Mehrotra, Megha; Avelino-Silva, Vivian I; McMahan, Vanessa; Veloso, Valdilea G; Anderson, Peter; Guanira, Juan; Grant, Robert

    2016-07-01

    Monitoring adherence to pre-exposure prophylaxis (PrEP) is part of the recommended package for PrEP prescribing, yet ongoing concerns about how to do so confidently are exacerbated by gross discrepancies in reported and actual use in clinical trials. We evaluated concordance between reports of recent PrEP dosing collected via neutral interviewing and drug quantitation in the iPrEx open-label extension, where participants (n = 1172) had the choice to receive or not receive PrEP. Self-report of recent dosing (at least one PrEP dose in the past 3-day) was the most common report (84 % of participants), and among these 83 % did have quantifiable levels of drug. The vast majority of those reporting no doses in the past 3-day (16 % of the sample) did not have quantifiable levels of drug (82 %). Predictors of over-report of dosing included younger age and lower educational attainment. Monitoring recent PrEP use through neutral interviewing may be a productive approach for clinicians to consider in implementation of real-world PrEP. Strategies to capture longer term or prevention-effective PrEP use, particularly for younger cohorts, are needed.

  8. 78 FR 47051 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ..., Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla Para La Declarcion Anual De La... . SUPPLEMENTARY INFORMATION: Title: Employer's Annual Tax Return for Agricultural Employees (Form 943),...

  9. Rainfall erosivity in Brazil: A Review

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this paper, we review the erosivity studies conducted in Brazil to verify the quality and representativeness of the results generated and to provide a greater understanding of the rainfall erosivity (R-factor) in Brazil. We searched the ISI Web of Science, Scopus, SciELO, and Google Scholar datab...

  10. Recent developments on shotcrete applications in Brazil

    SciTech Connect

    Guimaraes Filho, J.D.; Guimaraes Neto, J.D.

    1995-12-31

    This article describes the development of shotcrete in Brazil, since its introduction in the country to the present. Firstly, the authors focus on the application, with an overview on the main projects in which shotcrete was used. Next, the evolution of fabrication of shotcrete equipment in Brazil and some new achievements in this area are shown.

  11. CHARCOAL-PRODUCING INDUSTRIES IN NORTHEASTERN BRAZIL

    EPA Science Inventory

    Charcoal workers in northeastern Brazil: Occupational risks and effects of exposure to wood smoke
    ABSTRACT
    Brazil has the largest production of charcoal in the world, which is used mostly in the iron and steel industries. In most of the production sites, the process is ba...

  12. Brazil = Brasil. America = Las Americas [Series].

    ERIC Educational Resources Information Center

    Toro, Leonor; And Others

    Written for teachers to use with migrant children in elementary grades, this bilingual English/Spanish social studies resource booklet provides an encyclopedia-style overview of Brazil's history, geography, economy, and culture. Topics include Brazil's form of government; geographic regions; holidays; climate; people; music; carnaval celebration;…

  13. Inequality and School Reform in Bahia, Brazil

    ERIC Educational Resources Information Center

    Reiter, Bernd

    2009-01-01

    This article compares public and community schools in Salvador, the state capital of Bahia, Brazil. Based on quantitative data analysis and qualitative research conducted on-site during three research trips in 2001, 2003 and 2005, the author finds that Brazil's extreme inequality and the associated concentration of state power in a few hands stand…

  14. 76 FR 5822 - Orange Juice From Brazil

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... juice from Brazil (71 FR 12183). The Commission is conducting a review to determine whether revocation... frozen concentrated orange juice for further manufacturing and NFC stands for conventional pasteurized... COMMISSION Orange Juice From Brazil AGENCY: United States International Trade Commission. ACTION:...

  15. Higher Education Reform in Brazil: Reinforcing Marketization

    ERIC Educational Resources Information Center

    de Siqueira, Angela C.

    2009-01-01

    Higher education in Brazil began based on institutions organized as isolated establishments, and mostly privately owned. Nonetheless, public institutions created as universities and developing research activities and other services became the desired ideal for higher education. The first educational institutions in Brazil were created in the…

  16. Counseling in Brazil: Past, Present, and Future

    ERIC Educational Resources Information Center

    Hutz-Midgett, Aida; Hutz, Claudio Simon

    2012-01-01

    This article describes counseling in Brazil, which is rooted in career and vocational guidance. Although considered a distinct discipline, counseling falls under the umbrella of psychology. The multicultural movement is gaining momentum in Brazil, and counselors are pioneers working with socioracial minority college students. This is an emerging…

  17. Popular Documentation and Communication Centres in Brazil.

    ERIC Educational Resources Information Center

    Cardoso, Ana Maria P.

    1993-01-01

    Presents a study of the popular documentation and communication centers in Brazil which have developed to preserve the history of the struggles of the lower classes and to act as popular information services that fill information needs not met by traditional libraries. Social, economic, and political issues in Brazil are outlined. (Contains 10…

  18. Rising Expectations in Brazil and Chile

    ERIC Educational Resources Information Center

    Elacqua, Gregory; Alves, Fatima

    2014-01-01

    Two themes connect Brazil and Chile: one is economic success; the other is social unrest. Protests rocked cities across Brazil in June 2013, and in Chile, recent student protests turned violent. Yet living conditions in both nations are better now than they've ever been. Successful economic and social reforms over the last two decades have…

  19. Deformed rotational bands in the doubly odd nuclei [sup 134]Pr and [sup 132]Pr

    SciTech Connect

    Hauschild, K.; Wadsworth, R.; Clark, R.M.; Hibbert, I.M. ); Beausang, C.W.; Forbes, S.A.; Nolan, P.J.; Paul, E.S.; Semple, A.T.; Wilson, J.N. ); Gizon, A.; Gizon, J.; Santos, D. ); Simpson, J. )

    1994-08-01

    The nuclei [sup 132,134]Pr have been investigated using the [sup 100]Mo([sup 37]Cl,[ital xn]) reactions at a beam energy of 155 MeV. Gamma rays were detected with the Eurogam array. Analysis of the data has revealed the presence of two new weakly populated decoupled bands in [sup 134]Pr. One of these bands has been linked into the normal-deformed states and is thought to be built on a [pi]([ital h][sub 11/2])[sup 2][direct product][nu]([ital f][sub 7/2],[ital h][sub 9/2]) configuration. The second band has been interpreted as being based on a [pi]([ital h][sub 11/2])[sup 3][direct product][nu][ital i][sub 13/2] intruder configuration within the second [beta][sub 2][congruent]0.3 prolate minimum. The known decoupled band in [sup 132]Pr (5[ital n] reaction channel) and the highly deformed band in [sup 130]La A([alpha]3[ital n]) have also been extended. The structure of all of these bands is discussed together with similar bands in nieghboring odd-odd nuclei.

  20. PR: Essentially Essential...the MISD Communication Team Training Handbook.

    ERIC Educational Resources Information Center

    Moore, Edward H.; Banach, William J., Ed.

    The suggestions, discussions, examples, and tips presented in this handbook are intended to help educators improve their public relations (PR) and communications skills. The first of the book's six chapters introduces the need for a written communications policy, good PR, regular communications, and feedback from audiences. The chapter's…

  1. PrEP (Pre-Exposure Prophylaxis) 101

    MedlinePlus

    ... negative and have taken PrEP for up to 5 years, no significant health effects have been seen. Learn more about how to protect yourself and get information tailored to meet your needs from CDC’s HIV Risk Reduction Tool (BETA). Can you start PrEP after you have ...

  2. Case Studies in e-RPL and e-PR

    ERIC Educational Resources Information Center

    Cameron, Roslyn; Miller, Allison

    2014-01-01

    The use of ePortfolios for recognition of prior learning (e-RPL) and for professional recognition (e-PR) is slowly gaining in popularity in the VET sector however their use is sporadic across educational sectors, disciplines, educational institutions and professions. Added to this is an array of purposes and types of e-RPL and e-PR models and…

  3. 33 CFR 110.255 - Ponce Harbor, P.R.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Floats for marking anchors in place will be allowed; stakes or mooring piles are prohibited. 33 CFR Ch. I... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Ponce Harbor, P.R. 110.255... ANCHORAGE REGULATIONS Anchorage Grounds § 110.255 Ponce Harbor, P.R. (a) Small-craft anchorage. On...

  4. 33 CFR 110.255 - Ponce Harbor, P.R.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Floats for marking anchors in place will be allowed; stakes or mooring piles are prohibited. 33 CFR Ch. I... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Ponce Harbor, P.R. 110.255... ANCHORAGE REGULATIONS Anchorage Grounds § 110.255 Ponce Harbor, P.R. (a) Small-craft anchorage. On...

  5. 33 CFR 110.255 - Ponce Harbor, P.R.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Floats for marking anchors in place will be allowed; stakes or mooring piles are prohibited. 33 CFR Ch. I... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Ponce Harbor, P.R. 110.255... ANCHORAGE REGULATIONS Anchorage Grounds § 110.255 Ponce Harbor, P.R. (a) Small-craft anchorage. On...

  6. 33 CFR 110.255 - Ponce Harbor, P.R.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Floats for marking anchors in place will be allowed; stakes or mooring piles are prohibited. 33 CFR Ch. I... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Ponce Harbor, P.R. 110.255... ANCHORAGE REGULATIONS Anchorage Grounds § 110.255 Ponce Harbor, P.R. (a) Small-craft anchorage. On...

  7. 33 CFR 110.255 - Ponce Harbor, P.R.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Floats for marking anchors in place will be allowed; stakes or mooring piles are prohibited. 33 CFR Ch. I... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Ponce Harbor, P.R. 110.255... ANCHORAGE REGULATIONS Anchorage Grounds § 110.255 Ponce Harbor, P.R. (a) Small-craft anchorage. On...

  8. Praseodymium(III) sulfate hydroxide, Pr(SO(4))(OH).

    PubMed

    Wang, Xiao-Juan; Cheng, Jian-Wen

    2011-01-15

    The title compound, Pr(SO(4))(OH), obtained under hydro-thermal conditions, consists of Pr(III) ions coordinated by nine O atoms from six sulfate groups and three hydroxide anions. The bridging mode of the O atoms results in the formation of a three-dimensional framework, stabilized by two O-H⋯O hydrogen-bonding inter-actions.

  9. Prevalence of Self-Reported Diabetes and Its Associated Factors: A Population-Based Study in Brazil

    PubMed Central

    Da-Mata, Fabiana A. F.; Galvao, Tais F.; Pereira, Mauricio G.; Silva, Marcus T.

    2015-01-01

    Aim. The aim of this study was to estimate the prevalence of diabetes and its associated risk factors in adults from Brasilia, Brazil. Methods. The present cross-sectional population-based study consisted of interviews with individuals aged 18–65 years. Participants were selected through two-stage probability sampling by clusters and stratified by sex and age. Demographic and clinical data were collected directly with participants from February to May 2012. Self-reported diabetes prevalence was calculated at a 95% confidence interval (CI). Prevalence ratios (PR) were adjusted by Poisson regression with robust variance. Results. In all, 1,820 individuals were interviewed. Diabetes prevalence in the adult population of Brasilia was 10.1% (95% CI, 8.5%–11.6%). Variables associated with diabetes were an age between 35 and 49 years (PR = 1.83; 95% CI, 1.19–2.82) or 50 and 65 years (PR = 1.95; 95% CI, 1.17–3.23), hypertension (PR = 4.04; 95% CI, 2.66–6.13), respiratory disease (PR = 1.67; 95% CI, 1.11–2.50), cardiovascular disease (PR = 1.74; 95% CI, 1.15–2.63), and pain/discomfort (PR = 1.71; 95% CI, 1.21–2.41). Conclusion. Diabetes is a prevalent condition in adults living in Brasilia, and disease risk increases with age and comorbidities. Future health policies should focus on screening programs and prevention for the more vulnerable groups. PMID:26089888

  10. Brazil ALDF System Error Analysis

    NASA Technical Reports Server (NTRS)

    Rompala, John T.

    1999-01-01

    In a cooperative effort among: the Global Hydrology Climate Center (GHCC) of NASA's Marshal Space Flight Center (MSFC), the Atmospheric Electric Group of the Brazilian National Institute of Space Research, the University of San Paulo (USP), and the Brazilian National Institute of Meteorology (INME), a network of four lightning detectors has been established in Brazil's Rhondonian region. This paper surveys the efforts of GHCC researchers to develop algorithms and field procedures which reliable determine lightning strike locations based on site data comprised of the signal time of arrival, and radiated electromagnetic field.

  11. Geodiversity and geoconservation in Brazil

    NASA Astrophysics Data System (ADS)

    Cardozo Moreira, Jasmine; Muggler, Cristine Carole

    2014-05-01

    Brazil is a large country with a wide diversity of landscapes and geological features and has been an important world producer of mineral resources. Despite this, until the 90's of last century, there has not been much concern and policies about geological heritage and geoconservation. Only at the end of the century the National Geological Service (CPRM) included the physical characterization of areas with geotouristic interest in its mission of generation and diffusion of geological information. In 1997, was created the Brazilian Commission of Geological and Paleobiological Sites (SIGEP, http://sigep.cprm.gov.br), responsible for the assessment, description and publicizing the sites of geological heritage. This is by now the most comprehensive and relevant initiative to protect the national heritage. It is composed by a fully accessible national database composed by 167 certified sites presented as scientific papers. Furthermore, a web-based applicative for the inventory and protection of geological heritage sites is being developed by the National Geological Service. The wider knowledge about geological heritage can be a useful tool for its conservation and this has been an important goal in the creation of protected areas, by means of environmental education and tourism. In Brazil, actions, research and publications about the subject have increased in the last five years, as well as the outreach and responsible use of the geological heritage. Scientific meetings, conferences and courses are growing and spreading around the country. The main scientific meeting has been the Brazilian Symposium of Geological Heritage that in its second edition (2013) had more than 200 papers presented. At that meeting it was also created the Association in Defence of the Geomining Heritage and the Association of Aspiring Geoparks. Brazil has only one geopark in the Unesco's Global Geopark Network, that is the Araripe Geopark, created in 2006. By the moment, propositions are being

  12. Malaria in Brazil: an overview

    PubMed Central

    2010-01-01

    Malaria is still a major public health problem in Brazil, with approximately 306 000 registered cases in 2009, but it is estimated that in the early 1940s, around six million cases of malaria occurred each year. As a result of the fight against the disease, the number of malaria cases decreased over the years and the smallest numbers of cases to-date were recorded in the 1960s. From the mid-1960s onwards, Brazil underwent a rapid and disorganized settlement process in the Amazon and this migratory movement led to a progressive increase in the number of reported cases. Although the main mosquito vector (Anopheles darlingi) is present in about 80% of the country, currently the incidence of malaria in Brazil is almost exclusively (99,8% of the cases) restricted to the region of the Amazon Basin, where a number of combined factors favors disease transmission and impair the use of standard control procedures. Plasmodium vivax accounts for 83,7% of registered cases, while Plasmodium falciparum is responsible for 16,3% and Plasmodium malariae is seldom observed. Although vivax malaria is thought to cause little mortality, compared to falciparum malaria, it accounts for much of the morbidity and for huge burdens on the prosperity of endemic communities. However, in the last few years a pattern of unusual clinical complications with fatal cases associated with P. vivax have been reported in Brazil and this is a matter of concern for Brazilian malariologists. In addition, the emergence of P. vivax strains resistant to chloroquine in some reports needs to be further investigated. In contrast, asymptomatic infection by P. falciparum and P. vivax has been detected in epidemiological studies in the states of Rondonia and Amazonas, indicating probably a pattern of clinical immunity in both autochthonous and migrant populations. Seropidemiological studies investigating the type of immune responses elicited in naturally-exposed populations to several malaria vaccine candidates in

  13. Achieving optimum loop shapes in quaternary Pr-Co alloys

    NASA Astrophysics Data System (ADS)

    Branagan, D. J.; Kramer, M. J.; Tang, Yali; McCallum, R. W.

    2000-05-01

    The magnetic properties and microstructures of a quaternary Pr-Co-Ti-C alloy were investigated. After heat treating at 800 °C, the quaternary alloy developed high coercivity (16.7 kOe) and high energy product (8.6 MGOe). Hysteretic loop shapes exhibiting single-phase magnetic character were achieved which was a problem which previously plagued development of Pr-Co alloys. The optimum microstructure contained 75-100 nm Pr1Co5 hard magnetic grains, 75-100 nm Pr1Co2 second phases, and <10 nm TiC grain boundary precipitates. The important factors in achieving optimum loop shapes in Pr-Co alloys were examined in detail.

  14. PK-sensitive PrPSc is infectious and shares basic structural features with PK-resistant PrPSc

    Technology Transfer Automated Retrieval System (TEKTRAN)

    One of the main characteristics of the transmissible isoform of the prion protein (PrPSc) is its partial resistance to proteinase K (PK) digestion. Diagnosis of prion disease typically relies upon immunodetection of PK-digested PrPSc following Western blot or ELISA. More recently, researchers determ...

  15. PrP N-terminal domain triggers PrP{sup Sc}-like aggregation of Dpl

    SciTech Connect

    Erlich, Paul; Cesbron, Jean-Yves; Lemaire-Vieille, Catherine; Curt, Aurelie; Andrieu, Jean-Pierre; Schoehn, Guy; Jamin, Marc; Gagnon, Jean

    2008-01-18

    Transmissible spongiform encephalopathies are fatal neurodegenerative disorders thought to be transmitted by self-perpetuating conformational conversion of a neuronal membrane glycoprotein (PrP{sup C}, for 'cellular prion protein') into an abnormal state (PrP{sup Sc}, for 'scrapie prion protein'). Doppel (Dpl) is a protein that shares significant biochemical and structural homology with PrP{sup C}. In contrast to its homologue PrP{sup C}, Dpl is unable to participate in prion disease progression or to achieve an abnormal PrP{sup Sc}-like state. We have constructed a chimeric mouse protein, composed of the N-terminal domain of PrP{sup C} (residues 23-125) and the C-terminal part of Dpl (residues 58-157). This chimeric protein displays PrP-like biochemical and structural features; when incubated in presence of NaCl, the {alpha}-helical monomer forms soluble {beta}-sheet-rich oligomers which acquire partial resistance to pepsin proteolysis in vitro, as do PrP oligomers. Moreover, the presence of aggregates akin to protofibrils is observed in soluble oligomeric species by electron microscopy.

  16. TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

    PubMed Central

    2013-01-01

    Background Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline mutations in the TP53 gene. In Brazil, a particular mutation, occurring in the tetramerisation domain of the gene, p.R337H, is exceedingly common due to a founder effect and is strongly associated with ACC. In this report, we describe the phenotype and long-term clinical follow-up of a female child diagnosed with ACC and homozygous for the TP53 p.R337H founder mutation. Case presentation At age 11 months, the patient was diagnosed with a virilising anaplastic adrenal cortical tumour, which was completely excised without disturbing the adrenal capsule. Family history was consistent with an LFL tumour pattern, and genotyping identified the TP53 p.R337H mutation in both alleles in genomic DNA from lymphocytes and fibroblasts. Haplotype analysis confirmed the occurrence of the mutation in the same founder haplotype previously described in other Brazilian patients. No other germline or somatic TP53 mutations or rearrangements were identified. At age 9 years, the child was asymptomatic and had no evidence of endocrine derangements. Full body and brain magnetic resonance imaging (MRI) failed to detect any suspicious proliferative lesions, and cardiopulmonary exercise testing results were within the normal reference for the child’s age, ruling out a major exercise capacity deficiency. Conclusion This is the first clinical and aerobic functional capacity documentation of a patient who carries two mutant TP53 alleles and no wild-type allele. Our results support the hypothesis that TP53 p.R337H, the most common TP53 mutation ever described in any population, is a conditional mutant. Furthermore, our observations over a long period of clinical follow-up suggest that TP53 p.R337H homozygotes do not have a more severe disease phenotype than do heterozygote

  17. [Women and development in Brazil].

    PubMed

    Cunha Neves, A

    1980-01-01

    This paper discusses the social, political and cultural status of women in Brazil. In 1976 only 29.6% of Brazilian women participated in economic activities; 54.3% of these were still employed as laborers in the countryside, while only 6% were employed in urban and industrial jobs. The greatest concentration of female labor is in the category of the very badly paid domestic employment. Man is traditionally the head of the family, even when he is not the breadwinner. Illiteracy has decreased in Brazil to 24.3%, but female analphabetism is 26.5% versus 21.9% male analphabetism. Schools are open to males and females at all levels, but the traditional and cultural structure of Brazilian society considers the home, not the school, as the only proper place for young girls, and maternity is still the primary social function of women. Politically Brazilian women have very little power, even if they make up 44% of the electoral body. Sex education does not exist in the school or in the home, and any sexuality exercised outside the bonds of marriage is considered as deviant.

  18. Homosexuality and adoption in Brazil.

    PubMed

    Uziel, A P

    2001-11-01

    Western societies are undergoing legal and policy changes in relation to laws governing the family, marital status, sexual orientation and the welfare of children, including in Brazil where, in the 1990s, the rights of homosexuals were incorporated into ongoing debates about what constitutes a family. This paper discusses the issue of adoption of children by homosexual men in Brazil, using information from court records from 1995-2000 in Rio de Janeiro, and from interviews with two judges, five psychologists and four social workers who evaluate those wishing to adopt. It uses the case records of one man's application to adopt, in which homosexuality became a central issue. Both the construction of masculinity in relation to parenting and concepts of the family were the parameters upon which the decision to allow him to adopt or not depended. Because the legislation does not specify what the sexual orientation of would-be adoptive parents should be, it is possible for single persons to adopt if they show they can be good parents. As more single people, alone or in couples, seek to adopt, it is important to clarify the criteria for judicial decisions on adoption applications. A dialogue is therefore needed on the meaning of family and whether and how it relates to sexual orientation. It is only on this basis that the courts can take a clear decision as to whether being homosexual is a relevant issue in regard to applications to adopt or not.

  19. The prevalence and correlates of behavioral risk factors for cardiovascular health among Southern Brazil adolescents: a cross-sectional study

    PubMed Central

    2012-01-01

    Background The adoption of health-related behaviors is an important part of adolescence. This study examined the prevalence and correlates of the isolated and simultaneous presence of behavioral risk factors for cardiovascular health (BRFCH) among adolescents in Curitiba, Southern Brazil. Methods A cross-sectional study was performed with 1,628 adolescents (aged 11-17.9 years, 52.5% males) that were randomly selected from 44 public schools. Self-report instruments were used to assess the variables. Six BRFCH were analyzed: insufficiently active, excessive TV watching, current alcohol and tobacco use, daily soft drinks consumption and inadequate fruit and vegetable consumption. Sociodemographic and behavioral variables were studied as possible correlates of the presence of BRFCH. Results The BRFCH with the highest prevalence were insufficiently active (50.5%, 95% confidence interval [95% CI]: 48.0-52.9) and daily soft drinks consumption (47.6%, 95% CI: 45.1-50.0). Approximately 30% of the adolescents presented three or more BRFCH simultaneously. Girls, adolescents who did not participate in organized physical activity, and who used computer/video games daily were the main high-risk subgroups for insufficiently active. Boys and those who used computer/video games daily were the high-risk subgroups for daily soft drinks consumption. For excessive TV watching, we identified to be at risk those who were from a high economic class, unemployed, and who used computer/video games daily. For current alcohol use, we identified older adolescents, who were from a high economic class and who worked to be at risk. Older adolescents, who worked and who spent little active time during a physical education class were the high-risk subgroups for current tobacco use. For inadequate fruit and vegetable consumption, we identified those who did not participate in organized physical activity to be at risk. Older adolescents, who were from a high economic class, who did not participate

  20. Giardia duodenalis infection and anthropometric status in preschoolers in Salvador, Bahia State, Brazil.

    PubMed

    Matos, Sheila Maria Alvim; Assis, Ana Marlúcia Oliveira; Prado, Matildes da Silva; Strina, Agostino; Santos, Lenaldo Azevedo dos; Jesus, Sandra Rêgo de; Barreto, Maurício Lima

    2008-07-01

    The aim of this study was to estimate the association between Giardia duodenalis infection and anthropometric deficits, as measured by weight-for-age and height-for-age. This cross-sectional study included 629 children from 12 to 48 months of age, selected from 30 geographic areas in the city of Salvador, Bahia State, Brazil. Poisson regression and linear regression were used for the multivariate statistical analyses. G. duodenalis was diagnosed in 13.5% of the children. The children's breastfeeding duration and living conditions (garbage collection and paved streets or sidewalks) modified the effect of G. duodenalis infection on anthropometric status. Among infected children, there were statistically significant associations between weight deficit and shorter breastfeeding (PR=2.22; 95%CI: 1.56-3.14) and inadequate paving of streets and sidewalks (PR=2.00; 95%CI: 1.37-2.92), while height deficit was associated with deficient public garbage collection (PR=2.21; 95%CI: 1.31-2.51). In the linear regression, the association with the anthropometric indicators remained positive and statistically significant. The child's unhealthy living environment aggravated the negative effect of G. duodenalis infection on anthropometric status, and breastfeeding was a protective factor in the outcome.

  1. Proposed hydrologic analyses of streamflow for Brazil

    USGS Publications Warehouse

    Riggs, Henry Chiles

    1974-01-01

    Streamflow records are evaluated for the Rio Jacui basin in the state of Rio Grande Sul, Brazil, in reference to data reliability, length of record, and density of areal coverage. Availability of water is a factor in the development of a country, and surface water is of especial importance in Brazil. This report is intended as a reference for further investigation of the flow characteristic of the basin to provide (1) information for utilization of streamflow and (2) information to improve the data collection and analytic procedures. In addition the evaluation study can serve as a pilot for other developing river basins in Brazil. (Woodard-USGS)

  2. PREFACE: Brazil MRS Meeting 2014

    NASA Astrophysics Data System (ADS)

    2015-11-01

    The annual meetings, organized by the Brazilian materials research society - B-MRS, are amongst the most import discussion forums in the area of materials science and engineering in Brazil, with a growing interest from the national and international scientific society. In the last 4 years, more than 1,500 participants have attended the B-MRS meetings, promoting an auspicious environment for presentation and discussion of scientific and technological works in the materials science area. The XIII Brazilian Materials Research Society Meeting was held from 28 September to 02 October, 2014, in João Pessoa, PB, Brazil. The Meeting congregated more than 1650 participants from the whole of Brazil and from 28 other countries. More than 2100 abstracts were accepted for presentation, distributed along 19 Symposia following the format used in traditional meetings of Materials Research Societies. These involved topics such as: synthesis of new materials, computer simulations, optical, magnetic and electronic properties, traditional materials as clays and cements, advanced metals, carbon and graphene nanostructures, nanomaterials for nanostructures, energy storage systems, composites, surface engineering and others. A novelty was a symposium dedicated to innovation and technology transfer in materials research. The program also included 7 Plenary Lectures presented by internationally renowned researchers: Alberto Salleo from Stanford University, United States of America; Roberto Dovesi from Universita' degli Studi di Torino, Italy; Luís Antonio F. M. Dias Carlos from Universidade de Aveiro, Portugal; Jean Marie Dubois from Institut Jean-Lamour, France; Sir Colin Humphreys from University of Cambridge, England; Karl Leo from Technische Universität Dresden, Germany; Robert Chang from Northwestern University, Evanston, United States of America. The numbers of participants in the B-MRS meetings have been growing continuously, and in this meeting we had almost 2200 presentations

  3. Enthalpies of formation of Cd–Pr intermetallic compounds and thermodynamic assessment of the Cd–Pr system

    PubMed Central

    Reichmann, Thomas L.; Richter, Klaus W.; Delsante, Simona; Borzone, Gabriella; Ipser, Herbert

    2014-01-01

    In the present study standard enthalpies of formation were measured by reaction and solution calorimetry at stoichiometric compositions of Cd2Pr, Cd3Pr, Cd58Pr13 and Cd6Pr. The corresponding values were determined to be −46.0, −38.8, −35.2 and −24.7 kJ/mol(at), respectively. These data together with thermodynamic data and phase diagram information from literature served as input data for a CALPHAD-type optimization of the Cd–Pr phase diagram. The complete composition range could be described precisely with the present models, both with respect to phase equilibria as well as to thermodynamic input data. The thermodynamic parameters of all intermetallic compounds were modelled following Neumann–Kopp rule. Temperature dependent contributions to the individual Gibbs energies were used for all compounds. Extended solid solubilities are well described for the low- and high-temperature modifications of Pr and also for the intermetallic compound CdPr. A quite good agreement with all viable data available from literature was found and is presented. PMID:25540475

  4. Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.

    PubMed

    Miyazawa, Kohtaro; Okada, Hiroyuki; Masujin, Kentaro; Iwamaru, Yoshifumi; Yokoyama, Takashi

    2015-01-01

    Disease-related prion protein (PrP(Sc)), which is a structural isoform of the host-encoded cellular prion protein, is thought to be a causative agent of transmissible spongiform encephalopathies. However, the specific role of PrP(Sc) in prion pathogenesis and its relationship to infectivity remain controversial. A time-course study of prion-affected mice was conducted, which showed that the prion infectivity was not simply proportional to the amount of PrP(Sc) in the brain. Centrifugation (20,000 ×g) of the brain homogenate showed that most of the PrP(Sc) was precipitated into the pellet, and the supernatant contained only a slight amount of PrP(Sc). Interestingly, mice inoculated with the obtained supernatant showed incubation periods that were approximately 15 d longer than those of mice inoculated with the crude homogenate even though both inocula contained almost the same infectivity. Our results suggest that a small population of fine PrP(Sc) may be responsible for prion infectivity and that large, aggregated PrP(Sc) may contribute to determining prion disease duration.

  5. Clinician attitudes toward CDC interim pre-exposure prophylaxis (PrEP) guidance and operationalizing PrEP for adolescents.

    PubMed

    Mullins, Tanya L Kowalczyk; Lally, Michelle; Zimet, Gregory; Kahn, Jessica A

    2015-04-01

    Prior to issuing formal HIV pre-exposure prophylaxis (PrEP) clinical practice guidelines in 2014, the US Centers for Disease Control and Prevention (CDC) had released interim guidance for oral PrEP use among adults. Because oral PrEP may be used off-label for youth and may soon be indicated for minor adolescents, we examined the potential adoption of the interim guidance among clinicians who care for HIV-infected and at-risk youth. Individual, semi-structured interviews were conducted with 15 US clinicians who were recruited through an adolescent HIV research network. The theory-driven interview guide, consisting primarily of open-ended questions, assessed demographics, familiarity with the guidance, attitudes toward the guidance, and attitudes toward the use of the guidance for adult and adolescent patients. Transcripts were analyzed using framework analysis. Most clinicians (11/15) reported that the guidance was compatible with their practice, although several reported that some aspects, particularly frequency of follow-up visits, needed to be tailored to meet their patients' needs. We found variability in clinician reported characteristics of appropriate PrEP candidates (e.g., youth with substance use and mental health issues were noted to be both suitable and unsuitable PrEP candidates) and PrEP use in serodiscordant couples (e.g., whether PrEP would be recommended to a patient whose HIV-infected partner is virally suppressed). Clinician reported steps for initiation, monitoring, and discontinuing PrEP were largely consistent with the guidance. The observed variability in clinician practice with regard to oral PrEP may be reduced through interventions to educate clinicians about the content and rationale for guideline recommendations.

  6. An Energy Overview of Brazil

    SciTech Connect

    anon.

    2003-10-20

    The DOE Office of Fossil Energy is maintaining a web site that is meant to provide useful business- and energy-related information about countries and regions of the world for exporters, project developers, and researchers. The site consists of more than 130 country pages (organized into seven different world regions), with each country page having its own set of links to information sources about that country. There are also more than 30 Country Energy Overviews at the web site -- each of these is a comprehensive review of a specific country's entire energy situation, including sections on Energy Policy, Oil, Natural Gas, Coal, Hydroelectric/Renewables, Nuclear Power, Energy Transmission Infrastructure, Electricity, Electric Industry Overview, Environmental Activities, Privatization, Trade, and Economic Situation. The specific country highlighted in this Country Energy Overview is Brazil. The site is designed to be dynamic. Updates to the overviews will be made as need and resources permit.

  7. Reversing the Brazil Nut Effect

    NASA Astrophysics Data System (ADS)

    Ludewig, F.; Vandewalle, N.

    2005-12-01

    We propose a lattice model for studying the Brazil Nut Effect (BNE), i.e. the phase segregation occuring when a granular material is vertically shaked. The model considers the tap intensity and the mobility μ of the grains as the main physical parameters. Different mobilities for different grain species lead to segregation (BNE) patterns, reverse segregation (RBNE) patterns, “sandwhich" layered structures or vertical domains. A phase diagram (decompaction χ, mobility difference between both species Δ μ) is obtained in which the different phases are emphasized. In a narrow region of the diagram, different phases coexist. It is shown that the BNE segregation could be reversed by increasing the tap intensity or the characteristics of the grains. Numerical results are compared with earlier experimental works.

  8. [Rural workers' health in Brazil].

    PubMed

    Moreira, Jessica Pronestino de Lima; Oliveira, Bruno Luciano Carneiro Alves de; Muzi, Camila Drumond; Cunha, Carlos Leonardo Figueiredo; Brito, Alexandre dos Santos; Luiz, Ronir Raggio

    2015-08-01

    Workers' health is a central theme in public health surveys, but the specificity of work activities should be considered. This study aimed to analyze the health of rural workers in Brazil that perform both agricultural and non-agricultural work, based on self-rated health and self-reported diseases. The Brazilian National Household Sample Survey (PNAD 2008) was used, incorporating information from the complex sampling plan. Agricultural workers 18 years or older were selected, stratified according to those with and without non-agricultural work. Logistic regression was performed for self-rated health, and odds ratios were calculated for self-reported diseases. Exclusive agricultural work decreased the odds of reporting good health and increased the odds of reporting back pain, high blood pressure, and arthritis/rheumatism. Exclusive agricultural workers reported more diseases and worse living conditions. Self-rated health was generally better in workers with non-agricultural occupations. PMID:26375648

  9. Brazil comes in from the cold

    SciTech Connect

    Albright, D. )

    1990-12-01

    Brazil is well on its way to rolling back its nuclear program from the brink of developing nuclear explosives. The reason for this dramatic reversal can be traced to international diplomatic pressure on Brazil to accept full-scope safeguards and implement the Treaty of Tlatelolco, and to the growth of democracy in Brazil, which has provided an opportunity for groups such as the Brazilian Physics Society to work politically to end their country's effort to build nuclear weapons. The recent developments in Brazil underscore the importance of responsible civilian control of the nuclear program, and the role of domestic and international inspections of nuclear facilities to verify that weapons-related activities are not taking place. More importantly, these developments show that knowledgeable and dedicated people and groups opposed to nuclear weapons production can make a significant contribution to stopping their country from going nuclear.

  10. Brazil: Energy Options and Current Outlook

    ERIC Educational Resources Information Center

    Goldemberg, J.

    1978-01-01

    Brazil's energy options and current outlook are examined, and a summary of known reserves of fossil and renewable energy resources is given. Suggestions for an energy program designed to preserve Brazilian culture are included. (MDR)

  11. Telecommunications and Information Services in Brazil.

    ERIC Educational Resources Information Center

    Tarapanoff, Kira; Alvares, Lillian

    1995-01-01

    Discusses the interdependence of telecommunications and information sciences in Brazil. Highlights include new technologies and telecommunications: satellites, fiber optic cables, data communication networks, information superhighways, and cooperative projects; and information services development. (AEF)

  12. IgA- and SIgA anti-PR3 antibodies in serum versus organ involvement and disease activity in PR3-ANCA-associated vasculitis.

    PubMed

    Sandin, C; Eriksson, P; Segelmark, M; Skogh, T; Kastbom, A

    2016-05-01

    Circulating immunoglobulin (Ig)A class anti-neutrophil cytoplasm antibodies (ANCA) directed against proteinase 3 (PR3) have been reported in ANCA-associated vasculitis (AAV) with mucosal involvement. However, secretory IgA (SIgA) PR3-ANCA has not been reported previously. In this study we compared serum levels of SIgA PR3-ANCA and IgA PR3-ANCA with IgG PR3-ANCA in relation to disease characteristics. Among 73 patients with AAV and PR3-ANCA at diagnosis, 84% tested positive for IgG PR3-ANCA, 47% for IgA-ANCA and 36% for SIgA PR3-ANCA at the time of sampling for the present study. IgA and IgG PR3-ANCA were represented similarly among patients with different organ manifestations, i.e. upper airway, lung or kidney at time of sampling. However, SIgA PR3-ANCA was significantly less represented among patients with upper airway involvement. During active disease, the proportions of IgA PR3-ANCA and SIgA PR3-ANCA-positive patients were significantly higher compared to inactive disease. Eight patients were sampled prospectively during 24 months from onset of active disease. In these patients, IgA PR3-ANCA and SIgA PR3-ANCA turned negative more often after remission induction compared to IgG PR3-ANCA. Our findings suggest that serum IgA PR3-ANCA and SIgA PR3-ANCA are related more closely to disease activity in AAV compared to IgG PR3-ANCA. Further studies are required to reveal if this has implications for disease activity monitoring. The mean number of PR3-ANCA isotypes increased along with disease activity, suggesting a global B cell activation during active disease.

  13. Thermodynamic assessment of the Pr-O system

    SciTech Connect

    McMurray, Jake W.

    2015-12-24

    We found that the Calphad method was used to perform a thermodynamic assessment of the Pr–O system. Compound energy formalism representations were developed for the fluorite α-PrO 2–x and bixbyite σ-Pr 3 O 5 ± x solid solutions while the two-sublattice liquid model was used to describe the binary melt. The series of phases between Pr 2 O 3 and PrO 2 were taken to be stoichiometric. Moreover, the equilibrium oxygen pressure, phase equilibria, and enthalpy data were used to optimize the adjustable parameters of the models for a self-consistent representation of the thermodynamic behavior of the Pr–O system from 298 K to melting.

  14. Thermodynamic assessment of the Pr-O system

    DOE PAGES

    McMurray, Jake W.

    2015-12-24

    We found that the Calphad method was used to perform a thermodynamic assessment of the Pr–O system. Compound energy formalism representations were developed for the fluorite α-PrO 2–x and bixbyite σ-Pr 3 O 5 ± x solid solutions while the two-sublattice liquid model was used to describe the binary melt. The series of phases between Pr 2 O 3 and PrO 2 were taken to be stoichiometric. Moreover, the equilibrium oxygen pressure, phase equilibria, and enthalpy data were used to optimize the adjustable parameters of the models for a self-consistent representation of the thermodynamic behavior of the Pr–O system frommore » 298 K to melting.« less

  15. Thermochronological evidence for polyphase post-rift reactivation in SE Brazil

    NASA Astrophysics Data System (ADS)

    Cogné, N.; Gallagher, K.; Cobbold, P. R.; Riccomini, C.

    2012-04-01

    area cooled and uplifted during the Neogene. The synchronicity of the cooling phases with tectonic pulses in the Andes and in NE Brazil, as well as the tectonic setting of the Tertiary basins (Cogné et al., submitted) lead us to attribute these phases to a plate-wide compressive stress, which reactivated inherited structures during the Late Cretaceous and Tertiary. The relief of the margin is therefore due, more to polyphase post-rift reactivation and uplift, than to rifting itself. - Cobbold, P.R., Meisling, K.E., Mount, V.S., 2001. Reactivation of an obliquely rifted margin, Campos and Santos Basins, Southeastern Brazil. AAPG Bulletin 85, 1925-1944. - Cogné, N., Gallagher, K., Cobbold, P.R., 2011. Post-rift reactivation of the onshore margin of southeast Brazil: Evidence from apatite (U-Th)/He and fission-track data. Earth and Planetary Science Letters 309, 118-130. - Cogné, N., Cobbold, P.R., Riccomini, C., Gallagher, K. Tectonic setting of the Taubaté basin (southeastern Brazil): insights from regional seismic profiles and outcrop data. Submitted to Journal of South American Earth Sciences.

  16. PrEP implementation research in Africa: what is new?

    PubMed Central

    Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

    2016-01-01

    Introduction Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. Discussion In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an

  17. Agriculture, Rio Sao Francisco, Brazil, South America

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The large field patterns in this view of the Rio Sao Francisco basin, Brazil, South America, (11.5S, 43.5W) indicate a commercial agriculture venture; family subsistence farms are much smaller and laid out in different patterns. Land clearing in Brazil has increased at an alarming rate in recent years and preliminary estimates suggest a 25 to 30% increase in deforestation since 1984. The long term impact on the ecological processes are still unknown.

  18. Brazil: energy options and current outlook.

    PubMed

    Goldemberg, J

    1978-04-14

    Brazil's energy options and current outlook are examined, and a summary of known reserves of fossil and renewable energy resources is given. Brazil has abundant renewable energy resources but very modest reserves of fossil fuels. Consequently, the emphasis in the future will have to be on the utilization of solar energy, hydroelectric power, and biomass in a program designed to preserve local traditions and culture.

  19. SIM key comparison for luminous flux. SIM.PR-K4

    NASA Astrophysics Data System (ADS)

    Matamoros, Carlos H.; Ohno, Yoshi; Zwinkels, Joanne; Cogno, Jorge A.; Couceiro, Iakyra B.

    2016-01-01

    In compliance with the established BIPM and CCPR policies and guidelines on comparisons, the SIM Photometry and Radiometry Working Group decided to conduct a key comparison on total luminous flux in order to provide an opportunity for its member National Metrology Institutes (NMIs) that did not participate in the CCPR-K4 comparison, to get a link to the reference value obtained for this quantity (the lumen) and to derive the corresponding degrees of equivalence. This SIM.PR-K4 was piloted by Centro Nacional de Metrología (CENAM), the NMI of Mexico and included the participation of five laboratories: CENAM (Mexico), INTI (Argentina), INMETRO (Brazil), NIST (USA, linking lab), and NRC (Canada, linking lab). The comparison, conducted in star type scheme, was run using three to four lamps per participant, and results are given in this report, including the unilateral degrees of equivalence. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCPR, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  20. Thermodynamic database for the Co-Pr system

    PubMed Central

    Zhou, S.H.; Kramer, M.J.; Meng, F.Q.; McCallum, R.W.; Ott, R.T.

    2016-01-01

    In this article, we describe data on (1) compositions for both as-cast and heat treated specimens were summarized in Table 1; (2) the determined enthalpy of mixing of liquid phase is listed in Table 2; (3) thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W. PMID:26900594

  1. Thermodynamic database for the Co-Pr system.

    PubMed

    Zhou, S H; Kramer, M J; Meng, F Q; McCallum, R W; Ott, R T

    2016-03-01

    In this article, we describe data on (1) compositions for both as-cast and heat treated specimens were summarized in Table 1; (2) the determined enthalpy of mixing of liquid phase is listed in Table 2; (3) thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W. PMID:26900594

  2. Membranotropic regions of the dengue virus prM protein.

    PubMed

    Nemésio, Henrique; Villalaín, José

    2014-08-19

    The Dengue virus (DENV) prM protein consists of two moieties, the pr and M domains. Apart from preventing the premature fusion activity of the DENV E protein, prM has several other unknown biological roles, displaying both protein-protein and membrane-protein interactions. Although the prM protein is an essential component of the DENV viral cycle, little is known about its biological functions and what regions of this protein are responsible for said functions. By performing an exhaustive study of membrane rupture induced by a prM peptide library on simple and complex model membranes as well as their ability to modulate the phospholipid phase transitions of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine and 1,2-dimyristoyl-sn-glycero-3-[phospho-rac-glycerol], we identified six membranotropic regions on the prM protein. Apart from the previously identified two transmembrane segments of the protein, one of these regions probably interacts with the fusion E protein and another one, the stem segment, would interact with the membrane modulating its structure. These data will help us understand the molecular mechanism of viral entry and morphogenesis, allow the identification of new targets for the treatment of Dengue virus infection, and make possible the future development of DENV entry inhibitors. PMID:25076193

  3. Population fluctuation and faunal indices of aphids (Hemiptera, Aphididae) in peach orchards in Araucária, PR.

    PubMed

    Schuber, J M; Monteiro, L B; Poltronieri, A S; Carvalho, R C Z; Zawadneak, M A C

    2009-08-01

    Aphids are sap-sucking insects that mainly attack shoots and young leaves of peach trees and many other plant species; however, knowledge of the Brazilian aphid fauna is scant. The objective of this study was to identify aphid species collected in peach orchards (Prunus persica Batsch) and to determine their faunal indices for occurrence and dominance. The experiment was conducted from July 2005 to September 2006 in six Chimarrita peach orchards in the municipality of Araucária, PR, Brazil. The survey of aphid species was conducted by visual samplings on peach trees and using Möericke-type yellow traps containing water. A faunal analysis was made using aphid occurrence and dominance indices. Brachycaudus persicae (Passerini, 1860) was the only aphid species that was found colonizing peach in Araucária/PR. Although most aphids collected were classified as rare, some can be considered potential peach colonizers, such as Myzus persicae (Sulzer, 1776) which was given the status of common or intermediate in some of the orchards studied. The population fluctuation of aphids showed a negative correlation with rainfall and positive correlation with temperature and relative humidity. PMID:19802456

  4. 75 FR 44847 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ..., Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla Para La Declarcion Anual De La... Employees (Form 943), Planilla Para La Declarcion Anual De La Contribucion Federal Del Patrono De...

  5. Establishment of procedures for studying mPR-interacting agents and physiological roles of mPR.

    PubMed

    Tokumoto, Toshinobu; Hossain, Md Babul; Wang, Jun

    2016-07-01

    More than 10years have passed since the discovery of membrane progestin receptors (mPRs). Although the identification of mPR genes in various organisms and mPR expression patterns have been described since then, the precise physiological roles of mPRs are still unclear, except their function as a receptor for maturation-inducing steroid in fish. The wide distribution of mPRs suggests variable actions for progestins through mPRs in the tissues. Information about the physiological roles of mPRs, such as roles in the progression of breast cancer and T-cell proliferation, has gradually accumulated recently. These results suggest that mPRs are possible targets for new pharmaceuticals. We established a cell line that was transformed with cDNAs for mPRα and a recombinant luciferase gene named GloSensor. The cells can be used for monitoring the effects of ligands on mPRα based on intracellular cyclic adenosine monophosphate (cAMP) levels. Studies using these cell lines indicated that the cAMP concentration is decreased by ligands for mPRα. The results provide support for previous results suggesting that mPRα is coupled to inhibitory G protein (Gi). We also established screening methods that make it possible to screen ligands for mPR. Recently, we succeeded in expressing and purifying recombinant mPR protein in the yeast Pichia pastoris. Relatively large amounts of mPR protein with hormonal binding activity can be purified by our method. The recombinant protein will be applicable to establishing a molecular probe to detect mPR-interacting agents. To obtain decisive evidence for the roles of mPRs, we are establishing strains of medaka fish that are deficient in mPRs. In medaka, four subtypes of mPR genes (α, β, γ, and α2) have been identified. By reverse genetic screening, we have selected three to four strains in which a point mutation has been induced in the coding sequence of the mPR subtypes. However, homozygous mutants of each mPR gene showed no phenotype. The

  6. Deforestation near Rio Branco, Brazil

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Settlement and deforestation surrounding the Brazilian town of Rio Branco are seen here in the striking 'herring bone' deforestation patterns that cut through the rainforest. Rio Brancois the capital of the Brazilian state of Acre and is situated near the border with northeastern Bolivia. The town is a center for the distribution of goods, including rubber, metals, medicinal plants, Brazil nuts and timber. Colonization projects in the region are supported by farming, logging activities, and extensive cattle ranching. Much of the surrounding terrain is of a poorly-draining clay hardpan soil, and heavy rainfall periodically converts parts of the forested region to swamp.

    The large overview image was acquired by the Multi-angle Imaging SpectroRadiometer's vertical-viewing (nadir) camera on July 28, 2000, and covers an area of 336 kilometers x 333 kilometers. A plume of smoke is visible north of the Rio Branco road, which roughly parallels the slender, twisting Rio Abuna. Most of the major rivers in the image provide reference points for state or international (Bolivia-Brazil) boundaries, and flow northeast to the Rio Madeira (east of the smoke plume). The border between Acre and the Bolivian department of Pando is marked by the Rio Abuna. Pando's southern boundary with the department of Beni is marked by the Rio Madre de Dios, the large river in the lower half of the image.

    The two higher-resolution inset images highlight a settled area north of the town of Rio Branco. These nadir views cover an area of 60 kilometers x 67 kilometers, and were acquired eleven months apart during Terra orbits 3251 and 8144. In the later image, more haze is present, possibly due to smoke from fires on that day. Comparing the two images provides a method of measuring the changes and expansion in the area of cleared land. One newly cleared patch is apparent near the middle of the later image, slightly off to the right. This polygon represents an area of about 16 square kilometers, or

  7. Optimizing Content for Pre-Exposure Prophylaxis (PrEP) Counseling for Men who have Sex with Men: Perspectives of PrEP Users and High-risk PrEP Naïve Men

    PubMed Central

    Taylor, S. Wade; Mayer, Kenneth H.; Elsesser, Steven M.; Mimiaga, Matthew J.; O’Cleirigh, Conall; Safren, Steven A.

    2014-01-01

    Existing trials of antiretroviral (ARV) medication as chemoprophylaxis against HIV reveal that the degree of protection is primarily dependent on product adherence. However, there is a lack of data on targets for behavioral interventions to improve adherence to ARV as prevention. Information from individuals who have used ARV as pre-exposure prophylaxis (PrEP) can inform behavioral intervention development. Thirty-nine HIV-uninfected MSM at high risk for HIV acquisition participated in one of four semi-structured focus groups. Two of the focus groups consisted of MSM who had been prescribed and used PrEP in the context of a clinical trial; the other two consisted of high-risk MSM who had not previously used PrEP. An in-depth, within-case/across-case content analysis resulted in six descriptive themes potentially salient for a PrEP adherence behavioral intervention: (1) motivations to use PrEP, (2) barriers to PrEP use, (3) facilitators to PrEP use, (4) sexual decision-making in the context of PrEP, (5) prospective PrEP education content, and, (6) perceived effective characteristics of PrEP delivery personnel. Addressing these themes in behavioral interventions in the context of prescribing PrEP may result in the optimal “packaging” public health programs that implement PrEP for high-risk MSM. PMID:24077928

  8. Seasonal PrEP for partners of migrant miners in southern Mozambique: a highly focused PrEP intervention

    PubMed Central

    Cremin, Ide; Morales, Fernando; Jewell, Britta L; O'Reilly, Kevin R; Hallett, Timothy B

    2015-01-01

    Introduction To be used most effectively, pre-exposure prophylaxis (PrEP) should be prioritized to those at high risk of acquisition and would ideally be aligned with time periods of increased exposure. Identifying such time periods is not always straightforward, however. Gaza Province in southern Mozambique is characterized by high levels of HIV transmission and circular labour migration to mines in South Africa. A strong seasonal pattern in births is observable, reflecting an increase in conception in December. Given the potential for increased HIV transmission between miners returning in December and their partners in Gaza Province, PrEP use by the latter would be a useful means of HIV prevention, especially for couples who wish to conceive. Methods A mathematical model was used to represent population-level adult heterosexual HIV transmission in Gaza Province. Increased HIV acquisition among partners of miners in December, coinciding with the miners’ return from South Africa, is represented. In addition to a PrEP intervention, the scale-up of treatment and recent scale-up of male circumcision that have occurred in Gaza are represented. Results Providing time-limited PrEP to the partners of migrant miners, as opposed to providing PrEP all year, would improve the cost per infection averted by 7.5-fold. For the cost per infection averted to be below US$3000, at least 85% of PrEP users would need to be good adherers and PrEP would need to be cheaper than US$115 per person per year. Uncertainty regarding incidence of HIV transmission among partners of miners each year in December has a strong influence on estimates of cost per infection averted. Conclusions Providing time-limited PrEP to partners of migrant miners in Gaza Province during periods of increased exposure would be a novel strategy for providing PrEP. This strategy would allow for a better prioritized intervention, with the potential to improve the efficiency of a PrEP intervention considerably, as well

  9. Novel receptor-like kinases in cacao contain PR-1 extracellular domains.

    PubMed

    Teixeira, Paulo José Pereira Lima; Costa, Gustavo Gilson Lacerda; Fiorin, Gabriel Lorencini; Pereira, Gonçalo Amarante Guimarães; Mondego, Jorge Maurício Costa

    2013-08-01

    Members of the pathogenesis-related protein 1 (PR-1) family are well-known markers of plant defence responses, forming part of the arsenal of the secreted proteins produced on pathogen recognition. Here, we report the identification of two cacao (Theobroma cacao L.) PR-1s that are fused to transmembrane regions and serine/threonine kinase domains, in a manner characteristic of receptor-like kinases (RLKs). These proteins (TcPR-1f and TcPR-1g) were named PR-1 receptor kinases (PR-1RKs). Phylogenetic analysis of RLKs and PR-1 proteins from cacao indicated that PR-1RKs originated from a fusion between sequences encoding PR-1 and the kinase domain of a LecRLK (Lectin Receptor-Like Kinase). Retrotransposition marks surround TcPR-1f, suggesting that retrotransposition was involved in the origin of PR-1RKs. Genes with a similar domain architecture to cacao PR-1RKs were found in rice (Oryza sativa), barrel medic (Medicago truncatula) and a nonphototrophic bacterium (Herpetosiphon aurantiacus). However, their kinase domains differed from those found in LecRLKs, indicating the occurrence of convergent evolution. TcPR-1g expression was up-regulated in the biotrophic stage of witches' broom disease, suggesting a role for PR-1RKs during cacao defence responses. We hypothesize that PR-1RKs transduce a defence signal by interacting with a PR-1 ligand.

  10. Valence of praseodymium in superconducting Pr(O,F)BiS2 single crystals

    NASA Astrophysics Data System (ADS)

    Ishii, Satoshi; Hongu, Yasuaki; Miura, Akira; Nagao, Masanori

    2016-06-01

    The praseodymium (Pr) valence in superconducting PrO1- x F x BiS2 (x = 0.13,0.23) single crystals was evaluated by X-ray photoelectron spectroscopy. The Pr 3d core level is split into 3d3/2 and 3d5/2 levels. Both PrO1- x F x BiS2 and Pr2S3, which contain only Pr3+, showed 3d spectra at a lower binding energy than Pr6O11, which contains both Pr3+ and Pr4+. Neither PrO1- x F x BiS2 nor Pr2S3 showed the characteristic satellites of Pr4+ in 3d5/2 spectra. The valence fluctuation between the Pr3+ and Pr4+ states was not confirmed, suggesting that Pr3+ is dominant in PrO1- x F x BiS2 (x = 0.13,0.23) single crystals.

  11. Understanding the Press Kit and Its Use by the Media: When PR Material Becomes News

    ERIC Educational Resources Information Center

    Weisgerber, Corinne

    2006-01-01

    This activity helps students understand the relationship between public relations (PR) writing and news writing by demonstrating how PR material gets used in the production of news stories. Considering that "more than 70 percent of daily newspaper copy emanates from PR-generated releases," it is important for students to learn how PR professionals…

  12. [The health system of Brazil].

    PubMed

    Montekio, Víctor Becerril; Medina, Guadalupe; Aquino, Rosana

    2011-01-01

    This paper describes the Brazilian health system, which includes a public sector covering almost 75% of the population and an expanding private sector offering health services to the rest of the population. The public sector is organized around the Sistema Único de Saúde (SUS) and it is financed with general taxes and social contributions collected by the three levels of government (federal, state and municipal). SUS provides health care through a decentralized network of clinics, hospitals and other establishments, as well as through contracts with private providers. SUS is also responsible for the coordination of the public sector. The private sector includes a system of insurance schemes known as Supplementary Health which is financed by employers and/or households: group medicine (companies and households), medical cooperatives, the so called Self-Administered Plans (companies) and individual insurance plans.The private sector also includes clinics, hospitals and laboratories offering services on out-of-pocket basis mostly used by the high-income population. This paper also describes the resources of the system, the stewardship activities developed by the Ministry of Health and other actors, and the most recent policy innovations implemented in Brazil, including the programs saúde da Familia and Mais Saúde.

  13. Epidemiology of neurocysticercosis in Brazil.

    PubMed

    Agapejev, S

    1996-01-01

    A revision of literature was done with the objective of tracing an epidemiologic profile of neurocysticercosis (NCC) in Brazil. The prevalence was 0.12-9% in autopsies. The frequency was 0.03-7.5% in clinical series and 0.68-5.2% in seroepidemiological studies. The disease corresponds to 0.08-2.5% of admissions to general hospitals. Patient origin was rural in 30-63% of cases. The most involved age range (64-100%) was 11 to 60 years, with a predominance (22-67%) between 21 and 40 years. The male sex was the most affected (51-80%). In the severe forms there was a predominance of urban origin (53-62%) and of the female sex (53-75%). The period of hospitalization ranges from 1 to 254 days and 33 to 50% of patients suffer 1.7 +/- 1.4 admissions. The clinical picture was variable, with a predominance of epileptic syndrome (22-92%) and intracranial hypertension (19-89%). Psychiatric manifestations were associated in 9-23% of patients. Lethality was 0.29% in terms of all diseases in general and 4.8-25.9% in terms of neurologic diseases. The asymptomatic form was detected in 6% of patients in clinical series and in 48.5% of case from autopsies. The racemose form and ventricular localization also was observed as asymptomatic form. Among the patients with cutaneous cysticercosis 65% of them showed neurologic manifestations.

  14. Indigenous Child Health in Brazil

    PubMed Central

    del Pino Marchito, Sandra; Vitoy, Bernardino

    2016-01-01

    Abstract Improving the health status of indigenous children is a long-standing challenge. Several United Nations committees have identified the health of indigenous peoples as a human rights concern. Addressing the health of indigenous children cannot be separated from their social, cultural, and historic contexts, and any related health program must offer culturally appropriate services and a community perspective broad enough to address the needs of children and the local worlds in which they live. Evaluations of programs must, therefore, address process as well as impacts. This paper assesses interventions addressing indigenous children’s health in Brazil, ranging from those explicitly targeting indigenous children’s health, such as the targeted immunization program for indigenous peoples, as well as more generalized programs, including a focus upon indigenous children, such as the Integrated Management of Childhood Illness. The paper discusses the tensions and complexities of ethnically targeted health interventions as well as the conceptual and methodological challenge of measuring the processes employed and their impact. The lessons learned, especially the need for countries to more systematically collect data and evaluate impacts using ethnicity as an analytical category, are drawn out with respect to ensuring human rights for all within health sector responses. PMID:27781012

  15. Brazil's neglected tropical diseases: an overview and a report card.

    PubMed

    Hotez, Peter J; Fujiwara, Ricardo T

    2014-08-01

    Today, the nation of Brazil leads the Western Hemisphere in terms of the number of its citizens living with neglected tropical diseases (NTDs). These diseases continue to trap Brazil's "bottom 20 million" in extreme poverty.

  16. Occupational health and safety in Brazil.

    PubMed Central

    Frumkin, H; Câmara, V de M

    1991-01-01

    BACKGROUND. Brazil is the world's fifth largest and sixth most populous nation. Its economy is varied, with strong manufacturing, agriculture, mining, and service sectors. Therefore, a wide variety of workplace hazards confronts its work force. This paper describes Brazil's occupational safety and health regulatory scheme, workers' compensation system, plant-level practices, training, and data collection. METHODS. We reviewed and analyzed Brazilian regulatory legislation and government and non-governmental organization (NGO) activity in occupational safety and health, as well as the structure and function of the workers' compensation system. We also reviewed available data on injuries and diseases from major sources, including the now-defunct Instituto Nacional do Previdencia Social (INPS) and the workers' compensation scheme, Seguro de Acidente de Trabalho (SAT). RESULTS. The incidence of workplace injuries has decreased in recent years and is now reported to be about 5 per 100 workers per year. The case fatality rate has been constant at about 5 fatalities per 1000 injuries. Less than 6% of reported injuries are classified as "diseases." Brazil's rates are comparable to those of Mexico and Zimbabwe, and two to four times higher than in most industrialized countries. CONCLUSIONS. Brazil has a high incidence of occupational injuries and diseases; these injuries and diseases are underreported; there is a large informal sector at special risk; and Brazil illustrates the disparity that exists in many countries between legislation on the books and legislation that is actually implemented. PMID:1836110

  17. Women's motivation to become dentists in Brazil.

    PubMed

    Kfouri, Maria G; Moyses, Samuel J; Moyses, Simone Tetu

    2013-06-01

    There has been a marked increase of women in dentistry in Brazil and in many countries around the world. The behavioral mechanisms behind the choice of career differ between men and women, and the inclination to care for others is thought by some to be more present in women than it is in men. This article discusses the reasons that lead women to choose dentistry as a profession in Brazil and the impact of feminization on the current and future profile of the profession, based on the ethics of care. The authors' review of the relevant literature published between 2000 and 2011, primarily in Brazil, suggests that whereas men have tended to choose dentistry as a good business opportunity, women have tended to base their decision on relations with other people and the flexibility of practicing the profession. Many women dentists have been found to decide to work fewer hours, report more interruptions in their activities, and have less preference to work in private practice than men dentists. In the view of service users and dental auxiliaries in Brazil, women dentists invest more time in their patients and communicate in a more pleasant, sensitive, and friendly manner. The conclusion suggests that characteristics often associated with women can affect the dental profession in Brazil by introducing greater concern with the promotion of health and other people's well-being in contrast to traditional dentistry based on curative procedures.

  18. Comparison of multiple genotyping methods for the identification of the cancer predisposing founder mutation p.R337H in TP53.

    PubMed

    Fitarelli-Kiehl, Mariana; Macedo, Gabriel S; Schlatter, Rosane Paixão; Koehler-Santos, Patricia; Matte, Ursula da Silveira; Ashton-Prolla, Patricia; Giacomazzi, Juliana

    2016-06-01

    Germline mutations in the TP53 gene are associated with Li-Fraumeni and Li-Fraumeni-Like Syndromes, characterized by increased predisposition to early-onset cancers. In Brazil, the prevalence of the TP53-p.R337H germline mutation is exceedingly high in the general population and in cancer-affected patients, probably as result of a founder effect. Several genotyping methods are used for the molecular diagnosis of LFS/LFL, however Sanger sequencing is still considered the gold standard. We compared performance, cost and turnaround time of Sanger sequencing, PCR-RFLP, TaqMan-PCR and HRM in the p.R337H genotyping. The performance was determined by analysis of 95 genomic DNA samples and results were 100% concordant for all methods. Sequencing was the most expensive method followed by TaqMan-PCR, PCR-RFLP and HRM. The overall cost of HRM increased with the prevalence of positive samples, since confirmatory sequencing must be performed when a sample shows an abnormal melting profile, but remained lower than all other methods when the mutation prevalence was less than 2.5%. Sequencing had the highest throughput and the longest turnaround time, while TaqMan-PCR showed the lowest turnaround and hands-on times. All methodologies studied are suitable for the detection of p.R337H and the choice will depend on the application and clinical scenario. PMID:27275664

  19. Comparison of multiple genotyping methods for the identification of the cancer predisposing founder mutation p.R337H inTP53

    PubMed Central

    Fitarelli-Kiehl, Mariana; Macedo, Gabriel S.; Schlatter, Rosane Paixão; Koehler-Santos, Patricia; Matte, Ursula da Silveira; Ashton-Prolla, Patricia; Giacomazzi, Juliana

    2016-01-01

    Abstract Germline mutations in the TP53 gene are associated with Li-Fraumeni and Li-Fraumeni-Like Syndromes, characterized by increased predisposition to early-onset cancers. In Brazil, the prevalence of the TP53-p.R337H germline mutation is exceedingly high in the general population and in cancer-affected patients, probably as result of a founder effect. Several genotyping methods are used for the molecular diagnosis of LFS/LFL, however Sanger sequencing is still considered the gold standard. We compared performance, cost and turnaround time of Sanger sequencing, PCR-RFLP, TaqMan-PCR and HRM in the p.R337H genotyping. The performance was determined by analysis of 95 genomic DNA samples and results were 100% concordant for all methods. Sequencing was the most expensive method followed by TaqMan-PCR, PCR-RFLP and HRM. The overall cost of HRM increased with the prevalence of positive samples, since confirmatory sequencing must be performed when a sample shows an abnormal melting profile, but remained lower than all other methods when the mutation prevalence was less than 2.5%. Sequencing had the highest throughput and the longest turnaround time, while TaqMan-PCR showed the lowest turnaround and hands-on times. All methodologies studied are suitable for the detection of p.R337H and the choice will depend on the application and clinical scenario. PMID:27275664

  20. Targeted survey of Newcastle disease virus in backyard poultry flocks located in wintering site for migratory birds from Southern Brazil.

    PubMed

    Marks, Fernanda S; Rodenbusch, Carla R; Okino, Cíntia H; Hein, Héber E; Costa, Eduardo F; Machado, Gustavo; Canal, Cláudio W; Brentano, Liana; Corbellini, Luís G

    2014-09-01

    Newcastle disease virus (NDV) causes a fast-spreading, highly contagious infectious disease in several bird species. Commercial poultry farms in Brazil were considered free of virulent NDV. Data on NDV infection levels in backyard poultry flocks and the epidemiology of the disease are limited. The aim of this study was to perform a NDV survey in backyard poultry from households flocks located around one of the main wintering sites for migratory wild birds in Brazil, and to identify potential risk factors associated with NDV. Backyard poultry may be sentinels and a source of infection for commercial poultry, since they may have as much contact with these birds as with migratory wild birds. Data were collected from 48 randomly selected households using an epidemiological questionnaire. Serum samples from poultry were tested for NDV antibodies using an ELISA, and tracheal and cloacal swabs were collected for NDV molecular detection. The risk factors were assessed using a multivariate Poisson regression with robust variance. The ELISA showed that 33.8% of the serum samples were positive for anti-NDV antibodies and in 42 households (87.5%) at least one NDV-positive bird was found. Tracheal and cloacal swabs were negative for NDV by real time RT-PCR, possible because within this region there might flow a low pathogenicity NDV strain, which can induce seroconversion with innaparent clinical findings. The prevalence ratio (PR) increased when farmers used their own replacement poultry to restock their flock (PR=1.64; 95% CI: 1.11-2.42). Furthermore, the increasing distance of the household flock from the "Laguna do Peixe" estuary was associated with decreasing NDV seropositivity (PR=0.94; 95% CI: 0.90-0.99). This is the first study in Brazil evaluating the presence of NDV and the associated risk factors in households with backyard poultry flocks. The great number of farms with seropositive birds indicates that the virus circulates in backyard flocks, and this breeding

  1. Targeted survey of Newcastle disease virus in backyard poultry flocks located in wintering site for migratory birds from Southern Brazil.

    PubMed

    Marks, Fernanda S; Rodenbusch, Carla R; Okino, Cíntia H; Hein, Héber E; Costa, Eduardo F; Machado, Gustavo; Canal, Cláudio W; Brentano, Liana; Corbellini, Luís G

    2014-09-01

    Newcastle disease virus (NDV) causes a fast-spreading, highly contagious infectious disease in several bird species. Commercial poultry farms in Brazil were considered free of virulent NDV. Data on NDV infection levels in backyard poultry flocks and the epidemiology of the disease are limited. The aim of this study was to perform a NDV survey in backyard poultry from households flocks located around one of the main wintering sites for migratory wild birds in Brazil, and to identify potential risk factors associated with NDV. Backyard poultry may be sentinels and a source of infection for commercial poultry, since they may have as much contact with these birds as with migratory wild birds. Data were collected from 48 randomly selected households using an epidemiological questionnaire. Serum samples from poultry were tested for NDV antibodies using an ELISA, and tracheal and cloacal swabs were collected for NDV molecular detection. The risk factors were assessed using a multivariate Poisson regression with robust variance. The ELISA showed that 33.8% of the serum samples were positive for anti-NDV antibodies and in 42 households (87.5%) at least one NDV-positive bird was found. Tracheal and cloacal swabs were negative for NDV by real time RT-PCR, possible because within this region there might flow a low pathogenicity NDV strain, which can induce seroconversion with innaparent clinical findings. The prevalence ratio (PR) increased when farmers used their own replacement poultry to restock their flock (PR=1.64; 95% CI: 1.11-2.42). Furthermore, the increasing distance of the household flock from the "Laguna do Peixe" estuary was associated with decreasing NDV seropositivity (PR=0.94; 95% CI: 0.90-0.99). This is the first study in Brazil evaluating the presence of NDV and the associated risk factors in households with backyard poultry flocks. The great number of farms with seropositive birds indicates that the virus circulates in backyard flocks, and this breeding

  2. 75 FR 51531 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... Internal Revenue Service Proposed Collection; Comment Request for Forms 941, 941-PR, 941- SS, 941-X, 941-X... Seguro Social Y Al Seguro Medicare), 941-SS (Employer's Quarterly Federal Tax Return-American Samoa, Guam... Number: 1545-0029. Form Numbers: 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule R (Form 941), Schedule...

  3. 78 FR 47056 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... Internal Revenue Service Proposed Collection; Comment Request for Forms 941, 941-PR, 941- SS, 941-X, 941-X... Federal Tax Return), 941-PR, 941-SS (Employer's Quarterly Federal Tax Return-American Samoa, Guam, the... Quarterly Federal Tax Return. OMB Number: 1545-0029. Form Numbers: 941, 941-PR, 941-SS, 941-X,...

  4. Probing structural differences between PrPC and PrPSc by surface nitration and acetylation: evidence of conformational change in the C-terminus

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We used two chemical modifiers, tetranitromethane (TNM) and acetic anhydride, which specifically target accessible tyrosine and lysine residues, respectively, to modify Syrian hamster recombinant PrP(90-231) (rPrP) and PrP27-30, aiming at finding locations of conformational change. Modified proteins...

  5. Air-driven Brazil nut effect

    NASA Astrophysics Data System (ADS)

    Naylor, M.; Swift, Michael; King, P.

    2003-07-01

    A large heavy object may rise to the top of a bed of smaller particles under the influence of vertical vibration, the “Brazil nut effect.” Recently it has been noted that interstitial air can influence the Brazil nut rise time. Here we report that the air movement induced by vertical vibration produces a very strong Brazil nut effect for fine granular beds. We use a porous-bottomed box to investigate the mechanism responsible for this effect and to demonstrate that it is related to the piling of fine beds, first reported by Chladni and studied by Faraday. Both effects are due to the strong interaction of the fine particles with the air, as it is forced through the bed by the vibration.

  6. Bolivia-Brazil gas line route detailed

    SciTech Connect

    Not Available

    1992-05-11

    This paper reports that state oil companies of Brazil and Bolivia have signed an agreement outlining the route for a 2,270 km pipeline system to deliver natural gas from Bolivian fields to Southeast Brazil. The two sides currently are negotiating details about construction costs as well as contract volumes and prices. Capacity is projected at 283-565 MMcfd. No official details are available, but Roberto Y. Hukai, a director of the Sao Paulo engineering company Jaako Poyry/Technoplan, estimates transportation cost of the Bolivian gas at 90 cents/MMBTU. That would be competitive with the price of gas delivered to the Sao Paulo gas utility Comgas, he the. Brazil's Petroleos Brasileiro SA estimates construction of the pipeline on the Brazilian side alone with cost $1.2-1.4 billion. Bolivia's Yacimientos Petroliferos Fiscales Bolivianos (YPFB) is negotiating with private domestic and foreign investors for construction of the Bolivian portion of the project.

  7. Epidemiological Scenario of Dengue in Brazil

    PubMed Central

    Fares, Rafaelle C. G.; Souza, Katia P. R.; Añez, Germán; Rios, Maria

    2015-01-01

    Dengue is the most important reemerging mosquito-borne viral disease worldwide. It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes. Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. PMID:26413514

  8. US/Brazil joint pilot project objectives

    SciTech Connect

    1997-12-01

    This paper describes a joint US/Brazil pilot project for rural electrification, whose major goals are: to establish technical, institutional, and economic confidence in using renewable energy (PV and wind) to meet the needs of the citizens of rural Brazil; to establish on-going institutional, individual and business relationships necessary to implement sustainable programs and commitments; to lay the groundwork for larger scale rural electrification through the use of distributed renewable technologies. The projects have supported low power home lighting systems, lighting and refrigeration for schools and medical centers, and water pumping systems. This is viewed as a long term project, where much of the equipment will come from the US, but Brazil will be responsible for program management, and sharing data gained from the program. The paper describes in detail the Brazilian program which was instituted to support this phased project.

  9. Brazil's sugarcane boom could affect regional temperatures

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2013-04-01

    With the world seeking to cut its dependence on fossil fuels, the use of bioethanol and other biofuels is on the rise. In Brazil, the second largest producer and consumer of bioethanol, this has led to a boom in sugarcane production. Based on new laws and trade agreements, researchers expect Brazil's production of sugarcane-derived ethanol to increase tenfold over the next decade, with considerable land being converted for growing sugarcane. Much of this expansion is expected to come at a loss of some of the country's cerrado savannas. So while a major aim of the turn to biofuels is to reduce the transfer of carbon to the atmosphere and mitigate global climate change, the shifting agricultural activity could have direct consequences on Brazil's climate by changing the region's physical and biogeochemical properties.

  10. URBANIZATION, EDUCATION AND RACIAL INTERMARRIAGE IN BRAZIL

    PubMed Central

    Mitchell, Colter; Fu, Xuaning; Heaton, Tim B.; Jacobson, Cardell K.

    2013-01-01

    Urbanization and education have brought numerous changes in societies around the world. One change is the contact of different groups, often with an attendant increase in intergroup marriage. In this paper we examine the intergroup intermarriage in Brazil in the context of changing urbanization and education. While intergroup marriage has been intensively examined in the United States, the topic has received less attention in Brazil. We use census data from 1991 and 2000, and national survey data from 2001 and 2008 to examine factors predicting intergroup marriage and the trends in intergroup marriage in Brazil. The results show higher rates of intermarriage in urban than in rural areas. Intermarriage is less common among the most educated people. While the rates of intermarriage are increasing substantially, the rates of change are diffuse across urban and rural areas, regions and education groups. PMID:24052666

  11. Commercial charcoal manufacture in Brazil

    SciTech Connect

    Rezende, M.E.; Lessa, A.; Pasa, V.; Sampaio, R.; Macedo, P.

    1993-12-31

    Brazil is the only country where charcoal has a major industrial us. Almost 40% of the pig iron and all the ferroalloys produced in the country are based on it and were established near Minas Gerais iron ore deposits using non-sustainable farm charcoal. Since the 1980s charcoal production from large eucalyptus forests is gradually increasing, accounting for 40% of the 8 million tonnes produced in 1991. Farm charcoal is produced when native forests are slashed to give way to farm land. Adequate techniques, labor rights or environmental concerns are not common in this scenario. In large eucalyptus forests charcoal production has a different business approach. Several kinds of masonry ovens are used in both scenarios. Continuous carbonization kilns are not feasible yet because of their high capital cost. The search for a new cheapest design or for the upgrading of the carbonization byproducts is a must. Promising results are shown. Plastics and fine chemicals were already obtained from wood tar. The first Brazilian pilot plant for wood tar fractionation will be started by 9/93. Ironworks have different profiles. Some plants are up-to-date integrated mini-steelworks. Others are small producers of pig ingots. They have in common the need to face coke ironmaking route. Brazilian exports of charcoal based iron and steel products have attained the goal until now. Future charcoal competitiveness will not be so easy. Although expertises believe that coke prices can not stand low for long time it poses additional difficulty to the Brazilian charcoal ironmaker. Three scenarios projected for the future of charcoal ironmaking show that as long as charcoal production costs are properly managed, charcoal will be competitive with coke. The authors defend a common research program that looks for technologies suited to the Brazilian reality.

  12. Challenges for malaria elimination in Brazil.

    PubMed

    Ferreira, Marcelo U; Castro, Marcia C

    2016-01-01

    Brazil currently contributes 42 % of all malaria cases reported in the Latin America and the Caribbean, a region where major progress towards malaria elimination has been achieved in recent years. In 2014, malaria burden in Brazil (143,910 microscopically confirmed cases and 41 malaria-related deaths) has reached its lowest levels in 35 years, Plasmodium falciparum is highly focal, and the geographic boundary of transmission has considerably shrunk. Transmission in Brazil remains entrenched in the Amazon Basin, which accounts for 99.5 % of the country's malaria burden. This paper reviews major lessons learned from past and current malaria control policies in Brazil. A comprehensive discussion of the scientific and logistic challenges that may impact malaria elimination efforts in the country is presented in light of the launching of the Plan for Elimination of Malaria in Brazil in November 2015. Challenges for malaria elimination addressed include the high prevalence of symptomless and submicroscopic infections, emerging anti-malarial drug resistance in P. falciparum and Plasmodium vivax and the lack of safe anti-relapse drugs, the largely neglected burden of malaria in pregnancy, the need for better vector control strategies where Anopheles mosquitoes present a highly variable biting behaviour, human movement, the need for effective surveillance and tools to identify foci of infection in areas with low transmission, and the effects of environmental changes and climatic variability in transmission. Control actions launched in Brazil and results to come are likely to influence control programs in other countries in the Americas. PMID:27206924

  13. Brazil's Higher Education Responses to the Global Challenges of the 21st Century. Thinking Brazil. No. 23

    ERIC Educational Resources Information Center

    Woodrow Wilson International Center for Scholars, 2006

    2006-01-01

    "Thinking Brazil" is an electronic publication of the Brazil Institute. This issue of "Thinking Brazil" highlights the research of Elizabeth Balbachevsky. On July 24, 2006, Elizabeth Balbachevsky, Woodrow Wilson Center Public Policy Scholar and Associate Professor of Political Science, Universidade de Sao Paulo, presented her research on the…

  14. [Brazil, land of choice for arbovirosis?].

    PubMed

    Bedin, F

    2007-06-01

    Scores of arboviroses have been indexed in Brazil with variable rates of morbidity and mortality. Emergence of arboviroses and their transmission by hematophageous vectors are closely related to the country's recent history and in particular to its economic, social and ecological development. Most arboviroses are caused by alphaviruses and flaviviruses. Some species of bunyavirus are also found. Brazil is often regarded as an arbovirus sanctuary where dormant or nonpathogenic viruses can find an optimal context to emerge or reinforce their pathogenic potential in the middle term. Currently yellow fever and especially dengue fever are major public health problems.

  15. [Fertility transition in Brazil. Causes and consequences].

    PubMed

    Carvalho, J A; Wong, L R

    1992-12-01

    This work examines the determinants and most important consequences of the Brazilian fertility decline. Brazil's total fertility rate declined from 6.2 in 1940 to around 3.5 in 1985. the decline began in the 1960s and amounted to 45% in about 20 years. The most rapid drop began in the late 1970s, with much of it concentrated in 2 specific periods: 1970-75 and 1980-85. The early period coincided with Brazil's so-called "Economic Miracle", a period of rapid growth accompanied however by deteriorating living conditions for the poorest population sectors. The second period coincided with the international economic crisis of the early 1980s, which was felt more strongly in Brazil than elsewhere in Latin America because of Brazil's greater degree of industrialization and closer integration into the world economy. Most of the fertility decline has been accomplished by use of just two contraceptive methods, oral contraceptives and sterilization, which together account for around 85% of contraceptive usage throughout Brazil. The third most common method, rhythm, accounts for just 6%. No reliable data on abortion are available, but it appears to be a common practice equally accessible to all socioeconomic strata despite greater associated health risks for poorer women. Brazil's fertility transition appears to have been a response to the process of proletarianization and urbanization underway in the country as well as to particular circumstances in the country. The most evident and immediate consequence of the continuous fertility decline over more than 20 years is the change in the age structure of the population. The proportions of children under 5 will decline from 14.4% in 1980 to 9.2% in 2010. The proportion aged 5-14 will decline from 24.5% to 17.4%, while the proportion aged 65 and over will increase from 4.0% to 5.6%. Brazil's recent demographic changes are scarcely reflected in development plans and political and social projects. There is almost no mention of the new

  16. Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.

    PubMed

    Bate, Clive; Nolan, William; Williams, Alun

    2016-01-01

    The prion diseases occur following the conversion of the cellular prion protein (PrP(C)) into disease-related isoforms (PrP(Sc)). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrP(C) in prion formation was examined using a cell painting technique. PrP(Sc) formation in two prion-infected neuronal cell lines (ScGT1 and ScN2a cells) and in scrapie-infected primary cortical neurons was increased following the introduction of PrP(C). In contrast, PrP(C) containing a GPI anchor from which the sialic acid had been removed (desialylated PrP(C)) was not converted to PrP(Sc). Furthermore, the presence of desialylated PrP(C) inhibited the production of PrP(Sc) within prion-infected cortical neurons and ScGT1 and ScN2a cells. The membrane rafts surrounding desialylated PrP(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane rafts surrounding PrP(C). Desialylated PrP(C) was less sensitive to cholesterol depletion than PrP(C) and was not released from cells by treatment with glimepiride. The presence of desialylated PrP(C) in neurons caused the dissociation of cytoplasmic phospholipase A2 from PrP-containing membrane rafts and reduced the activation of cytoplasmic phospholipase A2. These findings show that the sialic acid moiety of the GPI attached to PrP(C) modifies local membrane microenvironments that are important in PrP-mediated cell signaling and PrP(Sc) formation. These results suggest that pharmacological modification of GPI glycosylation might constitute a novel therapeutic approach to prion diseases.

  17. Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.

    PubMed

    Bate, Clive; Nolan, William; Williams, Alun

    2016-01-01

    The prion diseases occur following the conversion of the cellular prion protein (PrP(C)) into disease-related isoforms (PrP(Sc)). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrP(C) in prion formation was examined using a cell painting technique. PrP(Sc) formation in two prion-infected neuronal cell lines (ScGT1 and ScN2a cells) and in scrapie-infected primary cortical neurons was increased following the introduction of PrP(C). In contrast, PrP(C) containing a GPI anchor from which the sialic acid had been removed (desialylated PrP(C)) was not converted to PrP(Sc). Furthermore, the presence of desialylated PrP(C) inhibited the production of PrP(Sc) within prion-infected cortical neurons and ScGT1 and ScN2a cells. The membrane rafts surrounding desialylated PrP(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane rafts surrounding PrP(C). Desialylated PrP(C) was less sensitive to cholesterol depletion than PrP(C) and was not released from cells by treatment with glimepiride. The presence of desialylated PrP(C) in neurons caused the dissociation of cytoplasmic phospholipase A2 from PrP-containing membrane rafts and reduced the activation of cytoplasmic phospholipase A2. These findings show that the sialic acid moiety of the GPI attached to PrP(C) modifies local membrane microenvironments that are important in PrP-mediated cell signaling and PrP(Sc) formation. These results suggest that pharmacological modification of GPI glycosylation might constitute a novel therapeutic approach to prion diseases. PMID:26553874

  18. Synthesis of praseodymium hydroxide (Pr(OH)3) and praseodymium oxide (Pr6O11) nanorods via room temperature aging.

    PubMed

    Dodd, Aaron

    2013-02-15

    In this study, room-temperature aging has been investigated as an alternative to high-temperature hydrothermal processing for manufacturing Pr(OH)(3) nanorods. It was found that a simple process consisting of precipitation, washing, and room-temperature aging results in the formation of Pr(OH)(3) nanorods that are structurally different to those synthesized by hydrothermal processing. Rather than single crystals, the nanorods were found to consist of crystals viewed down the [12¯10] and [11¯00] axes sharing a common [0001] growth direction. Subsequent calcination yielded Pr(6)O(11) nanorods consisting of cubic crystals viewed down the [11¯0] and [11¯2¯] directions. The constituent crystals shared a common [110] direction parallel with the longitudinal rod axis.

  19. Physical inactivity and anthropometric measures in schoolchildren from Paranavaí, Paraná, Brazil

    PubMed Central

    Guilherme, Flávio Ricardo; Molena-Fernandes, Carlos Alexandre; Guilherme, Vânia Renata; Fávero, Maria Teresa Martins; dos Reis, Eliane Josefa Barbosa; Rinaldi, Wilson

    2015-01-01

    OBJECTIVE: To investigate the association between physical inactivity and anthropometric measures in schoolchildren from Paranavaí-Parana, Brazil. METHODS: Cross-sectional survey, carried out in July and August 2013. Sample of 566 students (287 boys and 279 girls) from 6th to 9th grade, aged 10 to 14 years, from public and private schools of Paranavaí - PR, Southern Brazil. The variables analyzed were: time of weekly physical activity through a questionnaire (physical inactivity <300 minutes/week), body mass index (BMI) and waist circumference (WC). In the statistical analysis, the U Mann-Whitney and Student's t tests were used for comparison between genders. To identify factors associated with insufficient levels of physical activity, univariate and multivariate logistic regression analysis was applied and expressed in Odds ratio (OR) and 95% confidence interval (95%CI). RESULTS: There was an association between physical inactivity and anthropometric measurements for BMI (p<0.001) and WC (p<0.001), with a prevalence rate of 56.1% and 52.7% of inactive adolescents, respectively. In the multivariate analysis, there was significant association of physical inactivity and overweight (OR 1.8, 95%CI: 1.1-3.0) and with increased waist circumference (OR 2.8, 95%CI: 1.4-3.8). CONCLUSIONS: Inadequate levels of physical activity is a determining factor for overweight and abdominal adiposity. Accordingly, preventive measures should be taken, especially in schools, emphasizing the importance of exercise for body composition control and weight reduction. PMID:25623726

  20. In practice, the theory is different: a processual analysis of breastfeeding in northeast Brazil.

    PubMed

    Scavenius, Michael; van Hulsel, Lonneke; Meijer, Julia; Wendte, Hans; Gurgel, Ricardo

    2007-02-01

    'Na prática, a teoria è outra' (in practice, the theory is different) is an old Brazilian saying. This phrase summarizes well the general practice of breastfeeding in Brazil: 'Breast is best' is central in the pregnant women's future oriented 'theory' of how their infant should be fed. In the subsequent weeks after delivery, however, in the daily practicalities of feeding their infant, this theory is, to a large extent, abandoned. The present study is based on a sample of 300 mothers in the city of Aracaju in the Northeast of Brazil. Through interviews, the differences and similarities between knowledge and practice with respect to infant feeding were established. An explanation of these differences is developed on the basis of a processual analysis of the qualitative and quantitative results of the interview data. Nearly all mothers were knowledgeable of the need to breastfeed, and nearly all mothers had initiated breastfeeding. However, only a minority was exclusively breastfeeding at the time of the interview. A distinction is made between a breastfeeding process and a de-breastfeeding process. The data suggest that mothers, in general, start the de-breastfeeding process with the positive intention of ameliorating the infant's situation without realizing the negative processual consequences that most likely ends in a cessation of breastfeeding. The study supports the view that health policy should underline the processual character of both breastfeeding and de-breastfeeding when promoting the importance of exclusive breastfeeding.

  1. Anti-Prion Drug mPPIg5 Inhibits PrPC Conversion to PrPSc

    PubMed Central

    McCarthy, James M.; Franke, Markus; Resenberger, Ulrike K.; Waldron, Sibeal; Simpson, Jeremy C.; Tatzelt, Jörg; Appelhans, Dietmar; Rogers, Mark S.

    2013-01-01

    Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans. The ‘protein only hypothesis’ advocates that PrPSc, an abnormal isoform of the cellular protein PrPC, is the main and possibly sole component of prion infectious agents. Currently, no effective therapy exists for these diseases at the symptomatic phase for either humans or animals, though a number of compounds have demonstrated the ability to eliminate PrPSc in cell culture models. Of particular interest are synthetic polymers known as dendrimers which possess the unique ability to eliminate PrPSc in both an intracellular and in vitro setting. The efficacy and mode of action of the novel anti-prion dendrimer mPPIg5 was investigated through the creation of a number of innovative bio-assays based upon the scrapie cell assay. These assays were used to demonstrate that mPPIg5 is a highly effective anti-prion drug which acts, at least in part, through the inhibition of PrPC to PrPSc conversion. Understanding how a drug works is a vital component in maximising its performance. By establishing the efficacy and method of action of mPPIg5, this study will help determine which drugs are most likely to enhance this effect and also aid the design of dendrimers with anti-prion capabilities for the future. PMID:23383136

  2. Effect of Lu-to-Y ratio and Mo coactivation on scintillation properties of LuYAG:Pr and LuAG:Pr,Mo crystals

    NASA Astrophysics Data System (ADS)

    Drozdowski, W.; Brylew, K.; Witkowski, M. E.; Drewniak, A.; Masewicz, Z.; Wojtowicz, A. J.; Kisielewski, J.; Świrkowicz, M.

    2016-09-01

    In this paper the basic scintillation and thermoluminescence properties of LuYAG:Pr and LuAG:Pr,Mo crystals are reported. It is shown that, primarily, both materials display significantly higher scintillation yields than their prototype LuAG:Pr. The results of radioluminescence, low and high temperature thermoluminescence, and scintillation time profile measurements are analyzed quantitatively to allow us a better understanding of the scintillation process in LuYAG:Pr and LuAG:Pr,Mo, as well as to let us propose or verify possible explanations of the observed yield enhancement.

  3. In vitro neutralization of prions with PrPSc-specific antibodies

    PubMed Central

    Taschuk, Ryan; Van der Merwe, Jacques; Marciniuk, Kristen; Potter, Andrew; Cashman, Neil; Griebel, Philip; Napper, Scott

    2015-01-01

    Abstract Prion diseases reflect the misfolding of a self-protein (PrPC) into an infectious, pathological isomer (PrPSc). By targeting epitopes uniquely exposed by misfolding, our group developed PrPSc-specific vaccines to 3 disease specific epitopes (DSEs). Here, antibodies induced by individual DSE vaccines are evaluated for their capacity to neutralize prions in vitro. For both purified antibodies and immunoreactive sera, the PrPSc-specific antibodies were equally effective in neutralizing prions. Further, there was no significant increase in neutralizing activity when multiple DSEs were targeted within an assay. At a low antibody concentration, the PrPSc-specific antibodies matched the neutralization achieved by an antibody that may act via both PrPC and PrPSc. At higher doses, however, this pan-specific antibody was more effective, potentially due to a combined deactivation of PrPSc and depletion of PrPC. PMID:26284508

  4. In vitro neutralization of prions with PrP(Sc)-specific antibodies.

    PubMed

    Taschuk, Ryan; Van der Merwe, Jacques; Marciniuk, Kristen; Potter, Andrew; Cashman, Neil; Griebel, Philip; Napper, Scott

    2015-01-01

    Prion diseases reflect the misfolding of a self-protein (PrP(C)) into an infectious, pathological isomer (PrP(Sc)). By targeting epitopes uniquely exposed by misfolding, our group developed PrP(Sc)-specific vaccines to 3 disease specific epitopes (DSEs). Here, antibodies induced by individual DSE vaccines are evaluated for their capacity to neutralize prions in vitro. For both purified antibodies and immunoreactive sera, the PrP(Sc)-specific antibodies were equally effective in neutralizing prions. Further, there was no significant increase in neutralizing activity when multiple DSEs were targeted within an assay. At a low antibody concentration, the PrP(Sc)-specific antibodies matched the neutralization achieved by an antibody that may act via both PrP(C) and PrP(Sc). At higher doses, however, this pan-specific antibody was more effective, potentially due to a combined deactivation of PrP(Sc) and depletion of PrP(C).

  5. Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice

    PubMed Central

    Ahn, Misol; Bajsarowicz, Krystyna; Oehler, Abby; Lemus, Azucena; Bankiewicz, Krystof; DeArmond, Stephen J.

    2014-01-01

    Prion disease is caused by a single pathogenic protein (PrPSc), an abnormal conformer of the normal cellular prion protein PrPC. Depletion of PrPC in prion knockout mice makes them resistant to prion disease. Thus, gene silencing of the Prnp gene is a promising effective therapeutic approach. Here, we examined adeno-associated virus vector type 2 encoding a short hairpin RNA targeting Prnp mRNA (AAV2-PrP-shRNA) to suppress PrPC expression both in vitro and in vivo. AAV2-PrP-shRNA treatment suppressed PrP levels and prevented dendritic degeneration in RML-infected brain aggregate cultures. Infusion of AAV2-PrP-shRNA-eGFP into the thalamus of CD-1 mice showed that eGFP was transported to the cerebral cortex via anterograde transport and the overall PrPC levels were reduced by ∼70% within 4 weeks. For therapeutic purposes, we treated RML-infected CD-1 mice with AAV2-PrP-shRNA beginning at 50 days post inoculation. Although AAV2-PrP-shRNA focally suppressed PrPSc formation in the thalamic infusion site by ∼75%, it did not suppress PrPSc formation efficiently in other regions of the brain. Survival of mice was not extended compared to the untreated controls. Global suppression of PrPC in the brain is required for successful therapy of prion diseases. PMID:24866748

  6. Magnetic relaxation behaviour in Pr2NiSi3

    NASA Astrophysics Data System (ADS)

    Pakhira, Santanu; Mazumdar, Chandan; Ranganathan, R.

    2016-05-01

    Time dependent isothemal remanent magnetizatin (IRM) behaviour for polycrystalline compound Pr2NiSi3 have been studied below its characteristic temperature. The compound undergoes slow magnetic relaxation with time. Along with competing interaction, non-magnetic atom disorder plays an important role in formation of non-equilibrium glassy like ground state for this compound.

  7. Commentary: Communications Doesn't Define PR, It Diminishes It.

    ERIC Educational Resources Information Center

    Budd, John, Jr.

    1995-01-01

    Gives the dictionary definition of "communications," and then suggests that communications is the last act in the process of public relations. Presents hypothetical situations to show that PR is the final implementation step in a management process rather than just "communications." Argues that some companies, however, use communication as a…

  8. Marketing Your Library Program--More than a PR Campaign.

    ERIC Educational Resources Information Center

    Brown, Gerald R.

    In this workshop, the concept of marketing was applied to school library media programs by examining the relationship between library media programs, the marketing plan, public relations (PR), and promotion. Reachable goals, targeting the audience, advertising, and motivation and commitment of the staff were also considered, and successful…

  9. Involving ALL Your Publics. Basic School PR Guide.

    ERIC Educational Resources Information Center

    Ascough, Larry

    To help educators improve their school public relations (PR) programs, this handbook tells them how to identify and communicate with "special publics" and how to evaluate their communication efforts. An introductory overview points out that two-thirds to three-quarters of the adult population have no children in school and that schools need to…

  10. Selective recognition of Pr3+ based on fluorescence enhancement sensor.

    PubMed

    Ganjali, M R; Hosseini, M; Ghafarloo, A; Khoobi, M; Faridbod, F; Shafiee, A; Norouzi, P

    2013-10-01

    (E)-2-(1-(4-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene)hydrazinecarbothioamide (L) has been used to detect trace amounts of praseodymium ion in acetonitrile-water solution (MeCN/H2O) by fluorescence spectroscopy. The fluorescent probe undergoes fluorescent emission intensity enhancement upon binding to Pr(3+) ions in MeCN/H2O (9/1:v/v) solution. The fluorescence enhancement of L is attributed to a 1:1 complex formation between L and Pr(3+), which has been utilized as the basis for selective detection of Pr(3+). The sensor can be applied to the quantification of praseodymium ion with a linear range of 1.6×10(-7) to 1.0×10(-5) M. The limit of detection was 8.3×10(-8) M. The sensor exhibits high selectivity toward praseodymium ions in comparison with common metal ions. The proposed fluorescent sensor was successfully used for determination of Pr(3+) in water samples.

  11. Blue Pr{sup 3+}-doped ZBLAN fiber upconversion laser

    SciTech Connect

    Baney, D.M.; Rankin, G.; Chang, K.

    1996-09-01

    We demonstrate blue laser emission from a direct semiconductor laser-diode-pumped Pr{sup 3+}-doped upconversion fiber laser. This laser produced more than 1 mW of power at a wavelength of 492 nm from pump lasers operating at 830 and 1020 nm. {copyright} {ital 1996 Optical Society of America.}

  12. Draft Genome Sequence of Streptococcus agalactiae PR06

    PubMed Central

    MZ, Irma Syakina; Teh, L. K.

    2013-01-01

    Streptococcus agalactiae (group B streptococcus [GBS]) is a Gram-positive bacterium that was first recognized as a causative agent of bovine mastitis. S. agalactiae has subsequently emerged as a significant cause of human diseases. Here, we report the draft genome sequence of S. agalactiae PR06, which was isolated from a septicemic patient in a local hospital in Malaysia. PMID:23766409

  13. A TRMM-Calibrated Infrared Rainfall Algorithm Over Brazil. Part 1

    NASA Technical Reports Server (NTRS)

    Negri, Andrew J.; Adler, Robert F.; Xu, Liming; Einaudi, Franco (Technical Monitor)

    2001-01-01

    An improved version of the Convective/Stratiform Technique (CST) and its application over Brazil are presented. Keeping the major components of traditional CST, we have modified the scheme for classing convective and stratiform rainfall and tested various schemes to eliminate non-raining cirrus clouds. The parameters of the technique are calibrated using Tropical Rainfall Measuring Mission (TRMM) multi-sensor observations, including TMI, PR and Visible Infrared Scanner (VIRS). This technique takes advantage of the high temporal sampling rate of geosynchronous infrared channel and the better instantaneous rain observation of TRMM Microwave Imager (TMI) and PR. Moreover, sparse TMI rain estimates are used to dynamically calibrate the parameters of the technique to improve its performance. The technique is applied to make rainfall estimates on various time scales and to study rainfall statistics such as the distributions of rain intensity and storm duration over a four-month period beginning January 1999. The study period coincides with the TRMM/Large-Scale Biosphere-Atmosphere experiment in Amazonia (LBA) ground validation experiment, and observations from the LBA radar are used to validate the technique. Results show the mean diurnal cycle of precipitation over the LBA area, and are compared to radar data from the Tropical Oceans and Global Atmosphere (TOGA) radar. When the larger geographic region is considered, the analysis of the mean hourly estimates revealed the pronounced effects of rivers, topography and local circulations on the rainfall.

  14. [Socio-demographic and food insecurity characteristics of soup-kitchen users in Brazil].

    PubMed

    Godoy, Kátia Cruz; Sávio, Karin Eleonora Oliveira; Akutsu, Rita de Cássia; Gubert, Muriel Bauermann; Botelho, Raquel Braz Assunção

    2014-06-01

    This study aimed to characterize users of a government soup-kitchen program and the association with family food insecurity, using a cross-sectional design and random sample of 1,637 soup-kitchen users. The study used a questionnaire with socioeconomic variables and the Brazilian Food Insecurity Scale, and measured weight and height. The chi-square test was applied, and the crude and adjusted prevalence ratios (PR) were calculated using Poisson regression. Prevalent characteristics included per capita income ranging from one-half to one minimum wage (35.1%), complete middle school (39.8%), and food security (59.4%). Users in the North of Brazil showed the worst data: incomplete primary school (39.8%), per capita income up to one-half the minimum wage (50.8%), and food insecurity (55.5%). Prevalence ratios for food insecurity were higher among users with per capita income up to one-fourth the minimum wage (p < 0.05). Income was the only variable that remained associated with higher prevalence of food insecurity in the adjusted PR. Knowing the characteristics of soup-kitchen users with food insecurity can help orient the program's work, location, and operations. PMID:25099047

  15. [Socio-demographic and food insecurity characteristics of soup-kitchen users in Brazil].

    PubMed

    Godoy, Kátia Cruz; Sávio, Karin Eleonora Oliveira; Akutsu, Rita de Cássia; Gubert, Muriel Bauermann; Botelho, Raquel Braz Assunção

    2014-06-01

    This study aimed to characterize users of a government soup-kitchen program and the association with family food insecurity, using a cross-sectional design and random sample of 1,637 soup-kitchen users. The study used a questionnaire with socioeconomic variables and the Brazilian Food Insecurity Scale, and measured weight and height. The chi-square test was applied, and the crude and adjusted prevalence ratios (PR) were calculated using Poisson regression. Prevalent characteristics included per capita income ranging from one-half to one minimum wage (35.1%), complete middle school (39.8%), and food security (59.4%). Users in the North of Brazil showed the worst data: incomplete primary school (39.8%), per capita income up to one-half the minimum wage (50.8%), and food insecurity (55.5%). Prevalence ratios for food insecurity were higher among users with per capita income up to one-fourth the minimum wage (p < 0.05). Income was the only variable that remained associated with higher prevalence of food insecurity in the adjusted PR. Knowing the characteristics of soup-kitchen users with food insecurity can help orient the program's work, location, and operations.

  16. Evolution of the South Atlantic passive continental margin and lithosphere dynamic movement in Southern Brazil derived from zircon and apatite (U-Th-Sm)/He and fission-track data

    NASA Astrophysics Data System (ADS)

    Krob, Florian; Stippich, Christian; Glasmacher, Ulrich A.; Hackspacher, Peter C.

    2016-04-01

    Passive continental margins are important geoarchives related to mantle dynamics, the breakup of continents, lithospheric dynamics, and other processes. The main concern yields the quantifying long-term lithospheric evolution of the continental margin between São Paulo and Laguna in southeastern Brazil since the Neoproterozoic. We put special emphasis on the reactivation of old fracture zones running into the continent and their constrains on the landscape evolution. In this contribution, we represent already consisting thermochronological data attained by fission-track and (U-Th-Sm)/He analysis on apatites and zircons. The zircon fission-track ages range between 108.4 (15.0) and 539.9 (68.4) Ma, the zircon (U-Th-Sm)/He ages between 72.9 (5.8) and 427.6 (1.8) Ma whereas the apatite fission-track ages range between 40.0 (5.3) and 134.7 (8.0) Ma, and the apatite (U-Th-Sm)/He ages between 32.1 (1.52) and 92.0 (1.86) Ma. These thermochronological ages from metamorphic, sedimentary and intrusive rocks show six distinct blocks (Laguna, Florianópolis, Curitiba, Ilha Comprida, Peruibe and Santos) with different evolution cut by old fracture zones. Furthermore, models of time-temperature evolution illustrate the differences in Pre- to post-rift exhumation histories of these blocks. The presented data will provide an insight into the complex exhumation history of the continental margin based on the existing literature data on the evolution of the Paraná basin in Brazil and the latest thermochronological data. We used the geological model of the Paraná basin supersequences (Rio Ivaí, Paraná, Gondwana I-III and Bauru) to remodel the subsidence and exhumation history of our consisting thermochronological sample data. First indications include a fast exhumation during the early Paleozoic, a slow shallow (northern blocks) to fast and deep (Laguna block) subduction from middle Paleozoic to Mesozoic time and a extremely fast exhumation during the opening of the South Atlantic

  17. Satellite detection of tropical burning in Brazil

    NASA Technical Reports Server (NTRS)

    Matson, Michael; Holben, Brent

    1987-01-01

    Tropical burning often occurs in remote areas of the world. Satellite remote sensing is the only practical solution for detecting and monitoring this burning. The capability of the Advanced Very High Resolution Radiometer on board the National Oceanic and Atmospheric Administration polar orbiting satellites to detect tropical fire activity in the Manaus, Brazil area is demonstrated.

  18. Racial Inequality and Child Mortality in Brazil.

    ERIC Educational Resources Information Center

    Wood, Charles H.; Lovell, Peggy A.

    1992-01-01

    In 1980 urban Brazil, race of mother significantly affected child mortality after controlling for region, income, and parent education, with a mortality gap of 6.7 years between the whites and Afro-Brazilians. Parent education, indoor plumbing, access to public health care, and presence of adult females significantly reduced the probability of…

  19. Characterization of hantaviruses circulating in Central Brazil.

    PubMed

    Melo-Silva, Carolina R; Maranhão, Andrea Q; Nagasse-Sugahara, Teresa K; Bisordi, Ivani; Suzuki, Akemi; Brigido, Marcelo M

    2009-03-01

    In 2004, an outbreak of HCPS in Brazil made hantaviruses a national threat to the rural and urban population. During this outbreak, 164 cases were reported, and 18.3% of them occurred in the Federal District. In this study, hantavirus genomic sequences were amplified from seven patients who resided in Central Brazil and then sequenced and compared to other hantavirus sequences. The complete S segment sequence, which is 1847 bases long and potentially encodes the 428 amino acid nucleocapsid protein, was determined for one patient. Moreover, a 700 base-pair sequence of the S segment was obtained from two other patients, and we analyzed M segment sequences from all samples. It can be inferred by both identity and phylogenetic analysis that the sequences obtained are highly related to Araraquara variant and Maciel virus. Phylogenetic results show that hantaviruses isolated in Central Brazil can be divided into two monophyletic groups: one group that clusters with Araraquara variant and the other group that includes the complete S segment sequence obtained in this study. Therefore, we propose the name Paranoa for this variant that co-exists with the Araraquara-like hantavirus in Central Brazil.

  20. Ethnozoology in Brazil: current status and perspectives.

    PubMed

    Alves, Rômulo Rn; Souto, Wedson Ms

    2011-01-01

    Ancient connections between animals and human are seen in cultures throughout the world in multiple forms of interaction with the local fauna that form the core of Ethnozoology. Historically, ethnozoological publications grew out of studies undertaken in academic areas such as zoology, human ecology, sociology and anthropology--reflecting the interdisciplinary character of this discipline. The rich fauna and cultural diversity found in Brazil, with many different species of animals being used for an extremely wide diversity of purposes by Amerindian societies (as well as the descendents of the original European colonists and African slaves), presents an excellent backdrop for examining the relationships that exist between humans and other animals. This work presents a historical view of ethnozoological research in Brazil and examines its evolution, tendencies, and future perspectives. In summary, literature researches indicated that ethnozoology experienced significant advances in recent years in Brazil, although from a qualitative point of view improvement is still needed in terms of methodological procedures, taxonomic precision, and the use of quantitative techniques. A wide range of methodologies and theories are available in different areas of learning that can be put to good use in ethnozoological approaches if the right questions are asked. The challenges to studying ethnozoology in Brazil are not insignificant, and the tendencies described in the present study may aid in defining research strategies that will maintain the quantitative growth observed in the recent years but likewise foster needed qualitative improvements. PMID:21767370

  1. From Political to Economic Siege in Brazil.

    ERIC Educational Resources Information Center

    Academe, 1990

    1990-01-01

    Political forces in Brazil have caused significant economic changes, including hyperinflation, and policy that threaten higher education in a variety of ways, including failure to expand during a period of economic strength, severe loss of academic autonomy, lowering of academic and administrative standards, and declines in teacher education and…

  2. Technology and Terrorism in the Movie Brazil

    ERIC Educational Resources Information Center

    Stivers, Richard

    2006-01-01

    The movie "Brazil" calls attention to the relationship between technology and terrorism. Terrorism appears to be a threat to the order that technology creates. But terrorism forces technology to adapt and change so that technology perfects itself as a system. In the movie, terrorism is equated with any form of bureaucratic deviance so that…

  3. Hantaviruses and hantavirus pulmonary syndrome, Maranhao, Brazil.

    PubMed

    Travassos da Rosa, Elizabeth S; Sampaio de Lemos, Elba R; de Almeida Medeiros, Daniele B; Simith, Darlene B; de Souza Pereira, Armando; Elkhoury, Mauro R; Mendes, Wellington S; Vidigal, José R B; de Oliveira, Renata C; D'Andrea, Paulo S; Bonvicino, Cibele R; Cruz, Ana C R; Nunes, Márcio R T; da Costa Vasconcelos, Pedro F

    2010-12-01

    To confirm circulation of Anajatuba virus in Maranhao, Brazil, we conducted a serologic survey (immunoglobulin G ELISA) and phylogenetic studies (nucleocapsid gene sequences) of hantaviruses from wild rodents and persons with hantavirus pulmonary syndrome. This virus is transmitted by Oligoryzomys fornesi rodents and is responsible for hantavirus pulmonary syndrome in this region.

  4. Ethnozoology in Brazil: current status and perspectives

    PubMed Central

    2011-01-01

    Ancient connections between animals and human are seen in cultures throughout the world in multiple forms of interaction with the local fauna that form the core of Ethnozoology. Historically, ethnozoological publications grew out of studies undertaken in academic areas such as zoology, human ecology, sociology and anthropology - reflecting the interdisciplinary character of this discipline. The rich fauna and cultural diversity found in Brazil, with many different species of animals being used for an extremely wide diversity of purposes by Amerindian societies (as well as the descendents of the original European colonists and African slaves), presents an excellent backdrop for examining the relationships that exist between humans and other animals. This work presents a historical view of ethnozoological research in Brazil and examines its evolution, tendencies, and future perspectives. In summary, literature researches indicated that ethnozoology experienced significant advances in recent years in Brazil, although from a qualitative point of view improvement is still needed in terms of methodological procedures, taxonomic precision, and the use of quantitative techniques. A wide range of methodologies and theories are available in different areas of learning that can be put to good use in ethnozoological approaches if the right questions are asked. The challenges to studying ethnozoology in Brazil are not insignificant, and the tendencies described in the present study may aid in defining research strategies that will maintain the quantitative growth observed in the recent years but likewise foster needed qualitative improvements. PMID:21767370

  5. Culture Revisited: Vygotsky's Ideas in Brazil.

    ERIC Educational Resources Information Center

    Souza Lima, Elvira

    1995-01-01

    Examines educational reform and Vygotsky's influence on critical pedagogy in Brazil from two perspectives. One is the historical tradition of accepting multiplicity of learning behaviors, and the other is a close analysis of an environment that espoused the idea of literacy as a cultural production shared by everyone. (MMU)

  6. Brazil: The Lula Government and Financial Globalization

    ERIC Educational Resources Information Center

    Bianchi, Alvaro; Braga, Ruy

    2005-01-01

    The electoral victory of Lu?s In?cio "Lula" da Silva in the presidential elections of 2002 epitomized two decades of social and political transformations in Brazil. Nevertheless, instead of launching an alternative mode of doing politics, the program of the Workers' Party affirmed a state logic with a view to gradually updating the economic…

  7. Abortion in Brazil: legislation, reality and options.

    PubMed

    Guedes, A C

    2000-11-01

    Abortion is illegal in Brazil except when performed to save the woman's life or in cases of rape. This paper gives a brief history of parliamentary and extra-parliamentary efforts to change abortion-related legislation in Brazil in the past 60 years, the contents of some of the 53 bills that have been tabled in that time, the non-governmental stakeholders involved and the debate itself in recent decades. The authorities in Brazil have never assumed full public responsibility for reproductive health care or family planning, let alone legal abortion; the ambivalence of the medical profession is an important obstacle. Most politicians avoid getting involved in the abortion debate, but the majority of bills in the 1990s have favoured less restrictive legislation. Incremental legislative and health service changes could help to improve the situation for women. Advocacy is probably the most important action, to promote an environment conducive to change. Clandestine abortion is a serious public health problem in Brazil, and the inadequacy of family planning services is one of the causes of this problem. The solutions should be made a priority for the Brazilian public health system.

  8. Coccidioides posadasii Infection in Bats, Brazil

    PubMed Central

    Rocha de Castro e Silva, Kylvia; Brilhante, Raimunda Sâmia Nogueira; Moura, Francisco Bergson Pinheiro; Duarte, Naylê Francelino Holanda; Marques, Francisca Jakelyne de Farias; Filho, Renato Evando Moreira; Bezerra de Araújo, Roberto Wagner; Bandeira, Tereza de Jesus Pinheiro Gomes; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

    2012-01-01

    To analyze the eco-epidemiologic aspects of Histoplasma capsulatum in Brazil, we tested 83 bats for this fungus. Although H. capsulatum was not isolated, Coccidioides posadasii was recovered from Carollia perspicillata bat lungs. Immunologic studies detected coccidioidal antibodies and antigens in Glossophaga soricina and Desmodus rotundus bats. PMID:22469192

  9. Determinants of Educational Performance in Southern Brazil.

    ERIC Educational Resources Information Center

    Hansen, David O.

    The study examined the effects of socioeconomic origin (SES) and mental ability (MA) on levels of educational (EA) and occupational aspiration (OA), academic performance (AP), and significant others' influence (SOI) for 1,950 5th grade elementary and 4th year gymnastic students in Rio Grande do Sul, Brazil. Representative samples of approximately…

  10. Dengue situation in Brazil by year 2000.

    PubMed

    Schatzmayr, H G

    2000-01-01

    Dengue virus types 1 and 2 have been isolated in Brazil by the Department of Virology, Instituto Oswaldo Cruz, in 1986 and 1990 respectively, after many decades of absence. A successful continental Aedes aegypti control program in the Americas, has been able to eradicate the vector in most countries in the 60's, but the program could not be sustained along the years. Dengue viruses were reintroduced in the American region and the infection became endemic in Brazil, like in most Central and South American countries and in the Caribbean region, due to the weaning of the vector control programs in these countries. High demographic densities and poor housing conditions in large urban communities, made the ideal conditions for vector spreading. All four dengue types are circulating in the continent and there is a high risk of the introduction in the country of the other two dengue types in Brazil, with the development of large epidemics. After the Cuban episode in 1981, when by the first time a large epidemic of dengue hemorrhagic fever and dengue shock syndrome have been described in the Americas, both clinical presentations are observed, specially in the countries like Brazil, with circulation of more than one dengue virus type. A tetravalent potent vaccine seems to be the only possible way to control the disease in the future, besides rapid clinical and laboratory diagnosis, in order to offer supportive treatment to the more severe clinical infections.

  11. Microcephaly in Infants, Pernambuco State, Brazil, 2015

    PubMed Central

    2016-01-01

    We studied the clinical characteristics for 104 infants born with microcephaly in the delivery hospitals of Pernambuco State, Brazil, during 2015. Testing is ongoing to exclude known infectious causes. However, microcephaly peaked in October and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications consistent with an intrauterine infection. PMID:27071041

  12. Assessing Higher Education Learning Outcomes in Brazil

    ERIC Educational Resources Information Center

    Pedrosa, Renato H. L.; Amaral, Eliana; Knobel, Marcelo

    2013-01-01

    Brazil has developed an encompassing system for quality assessment of higher education, the National System of Higher Education Evaluation (SINAES), which includes a test for assessing learning outcomes at the undergraduate level, the National Exam of Student Performance (ENADE). The present system has been running since 2004, and also serves as…

  13. Implementing the Schoolwide Enrichment Model in Brazil

    ERIC Educational Resources Information Center

    de Souza Fleith, Denise; Soriano de Alencar, Eunice M. L.

    2010-01-01

    The Schoolwide Enrichment Model (SEM) has been one of the most widely used models in the education of the gifted in Brazil. It has inspired the political and pedagogical project of the Centers of Activities of High Abilities/Giftedness recently implemented in 27 Brazilian states by the Ministry of Education. In this article, our experience in…

  14. Waterborne Toxoplasmosis, Brazil, from Field to Gene

    PubMed Central

    de Moura, Lenildo; Bahia-Oliveira, Lilian Maria Garcia; Wada, Marcelo Y.; Jones, Jeffrey L.; Tuboi, Suely H.; Carmo, Eduardo H.; Ramalho, Walter Massa; Camargo, Natal J.; Trevisan, Ronaldo; Graça, Regina M.T.; da Silva, Alexandre J.; Moura, Iaci; Dubey, J.P.; Garrett, Denise O.

    2006-01-01

    Water was the suspected vehicle of Toxoplasma gondii dissemination in a toxoplasmosis outbreak in Brazil. A case-control study and geographic mapping of cases were performed. T. gondii was isolated directly from the implicated water and genotyped as SAG 2 type I. PMID:16494765

  15. Maternal-child health in Brazil.

    PubMed

    Beckmann, C A

    1987-01-01

    An overview of the social and economic climates and the healthcare delivery systems of Brazil is presented. The Brazilian healthcare system is discussed, with particular attention directed to the status of nursing and to the perinatal health-care delivery system. Examples of Brazilian perinatal health-care practices are provided. PMID:3650322

  16. Policies for control and prevention of infections related to healthcare assistance in Brazil: a conceptual analysis.

    PubMed

    Oliveira, Hadelândia Milon de; Silva, Cristiane Pavanello Rodrigues; Lacerda, Rúbia Aparecida

    2016-01-01

    This article is a theoretical-reflexive study that aims to discuss the development and changes in the quality of healthcare assistance to the patient over the years in Brazil, in light of the policies of control and prevention of Healthcare-associated Infection (HAI). Aspects of HAI and the process of change in health policy in Brazil, as well as the quality of assistance associated with its control, are approached in relation to policies of patient safety. There are various new theoretical and practical proposals created in Brazil. In spite of the difficulty of measuring patient safety, directed to the prevention and control of HAI, we emphasize that to only create policies and establish norms, guidelines, and indicators is not sufficient. If no structural support or conditions exist for interventions in the practices of healthcare professionals, aiming at results in acceptable levels, the control of HAI will not be achieved. Resumo Trata-se um estudo teórico-reflexivo, que objetiva discutir a evolução e as mudanças na qualidade da assistência ao paciente, ao longo dos anos no Brasil, à luz das políticas de controle e prevenção da Infecção Relacionada à Assistência à Saúde (IRAS). Aspectos sobre IRAS e o processo de mudança nas políticas de saúde no Brasil, bem como a qualidade da assistência associada ao seu controle, são abordados em relação às políticas de segurança do paciente. Há novas e várias propostas teóricas e práticas criadas no Brasil. Apesar da dificuldade de medir a segurança do paciente, direcionada à prevenção e controle das IRAS, enfatiza-se que somente criar políticas, estabelecer normas, diretrizes e indicadores não são suficientes. Se não houver suporte de estrutura e condições para as intervenções nas práticas dos profissionais na assistência prestada ao paciente, visando resultados em níveis aceitáveis, o controle das IRAS não será alcançado.

  17. Policies for control and prevention of infections related to healthcare assistance in Brazil: a conceptual analysis.

    PubMed

    Oliveira, Hadelândia Milon de; Silva, Cristiane Pavanello Rodrigues; Lacerda, Rúbia Aparecida

    2016-01-01

    This article is a theoretical-reflexive study that aims to discuss the development and changes in the quality of healthcare assistance to the patient over the years in Brazil, in light of the policies of control and prevention of Healthcare-associated Infection (HAI). Aspects of HAI and the process of change in health policy in Brazil, as well as the quality of assistance associated with its control, are approached in relation to policies of patient safety. There are various new theoretical and practical proposals created in Brazil. In spite of the difficulty of measuring patient safety, directed to the prevention and control of HAI, we emphasize that to only create policies and establish norms, guidelines, and indicators is not sufficient. If no structural support or conditions exist for interventions in the practices of healthcare professionals, aiming at results in acceptable levels, the control of HAI will not be achieved. Resumo Trata-se um estudo teórico-reflexivo, que objetiva discutir a evolução e as mudanças na qualidade da assistência ao paciente, ao longo dos anos no Brasil, à luz das políticas de controle e prevenção da Infecção Relacionada à Assistência à Saúde (IRAS). Aspectos sobre IRAS e o processo de mudança nas políticas de saúde no Brasil, bem como a qualidade da assistência associada ao seu controle, são abordados em relação às políticas de segurança do paciente. Há novas e várias propostas teóricas e práticas criadas no Brasil. Apesar da dificuldade de medir a segurança do paciente, direcionada à prevenção e controle das IRAS, enfatiza-se que somente criar políticas, estabelecer normas, diretrizes e indicadores não são suficientes. Se não houver suporte de estrutura e condições para as intervenções nas práticas dos profissionais na assistência prestada ao paciente, visando resultados em níveis aceitáveis, o controle das IRAS não será alcançado. PMID:27556723

  18. [Yellow fever epidemiology in Brazil].

    PubMed

    Mondet, B

    2001-08-01

    We have carried out a meticulous time-space-analysis of the incidence of yellow fever in humans in Brazil from 1954 to 1972 and especially from 1973 to 1999. This study has added to our knowledge of the epidemiology of yellow fever and enabled us to redefine epidemiological zones and determine their geographical limits. The endemic area is located within the Amazon basin; here cases are scattered and generally limited in number. However, there are also "foci of endemic emergence" within this area, where cases are less rare, although occurrence remains irregular. The epidemic area is for the most part situated outside the Amazon basin, to the north east and particularly to the south. It has been divided into two parts according to whether the occurrence of yellow fever is cyclic or sporadic. The epidemics, which are all sylvatic, follow either a circular path (in the forest area) or a linear path (in forest-galleries of the savannah area). The study of the development of the 3 main epidemics (1972-74; 1979-82; 1986-92) in the cyclic emergence area showed that, on each occasion, the yellow fever virus appeared at a particularly active outbreak site located in the "serra dos Carajás", and from there, it followed the courses of the Tocantins and Araguaia rivers upstream, moving southwards during the "pre-epidemic phase" which may be visible due to the occurrence of a few cases, or may remain invisible. Subsequently the virus reached the emergence area, where it appeared in the form of epidemics. In this zone, it also followed privileged south-western pathways, moving from one hydraulic basin to another along the upstream courses of the rivers. Almost exactly the same pathways have been identified for each of the 3 epidemics studied. The distances travelled by the virus over a period of one year--when it goes rapidly--can reach several hundred kilometers. On the other hand, it may be stationary for a period of one or two consecutive years, occasionally three, remaining

  19. Thermal discomfort and hypertension in bus drivers and chargers in the metropolitan region of Belo Horizonte, Brazil.

    PubMed

    Pimenta, Adriano Marçal; Assunção, Ada Ávila

    2015-03-01

    This study aimed to assess the relationship between perception of temperature inside the bus and hypertension among 1126 collective transportation workers in metropolitan region of Belo Horizonte, Brazil. Thermal discomfort was determined based on the perception of temperature inside the bus. Hypertension was determined if participant had a medical diagnosis of this disease. Prevalence ratios (PR) for hypertension and their respective 95% confidence intervals (95% CI) were adjusted using multivariate Poisson regression analysis. The perceptions of temperature inside the bus were tolerable (26.5%), disturbs a little (28.6%), disturbs a lot (34.8%) and unbearable (10.2%). The prevalence of hypertension was 14.3%. The thermal discomfort categories of disturbs a lot (PR = 1.41; 95% CI = 1.02-1.95) and unbearable (PR = 1.75; 95% CI = 1.16-2.63) were independently related to hypertension. Thermal discomfort was associated with a higher prevalence of hypertension. This finding should be considerate in new policies for public transportation.

  20. Screening for depressive symptoms in older adults in the Family Health Strategy, Porto Alegre, Brazil.

    PubMed

    Nogueira, Eduardo Lopes; Rubin, Leonardo Librelotto; Giacobbo, Sara de Souza; Gomes, Irenio; Cataldo Neto, Alfredo

    2014-06-01

    OBJECTIVE To analyze the prevalence of depression in older adults and associated factors. METHODS Cross-sectional study using a stratified random sample of 621 individuals aged ≥ 60 from 27 family health teams in Porto Alegre, RS, Southern Brazil, between 2010 and 2012. Community health agents measured depression using the 15-item Geriatric Depression Scale. Scores of ≥ 6 were considered as depression and between 11 and 15 as severe depression. Poisson regression was used to search for independent associations of sociodemographic and self-perceived health with both depression and its severity. RESULTS The prevalence of depression was 30.6% and was significantly higher in women (35.9% women versus 20.9% men, p < 0.001). The variables independently associated with depression were: female gender (PR = 1.4, 95%CI 1.1;1.8); low education, especially illiteracy (PR = 1.8, 95%CI 1.2;2 6); regular self-rated health (OR = 2.2, 95%CI 1.6;3.0); and poor/very poor self-rated health (PR = 4.0, 95%CI 2.9;5.5). Except for education, the strength of association of these factors increases significantly in severe depression. CONCLUSIONS A high prevalence of depression was observed in the evaluations conducted by community health agents, professionals who are not highly specialized. The findings identified using the 15-item Geriatric Depression Scale in this way are similar to those in the literature, with depression more associated with low education, female gender and worse self-rated health. From a primary health care strategic point of view, the findings become still more relevant, indicating that community health agents could play an important role in identifying depression in older adults. PMID:25119932

  1. Screening for depressive symptoms in older adults in the Family Health Strategy, Porto Alegre, Brazil

    PubMed Central

    Nogueira, Eduardo Lopes; Rubin, Leonardo Librelotto; Giacobbo, Sara de Souza; Gomes, Irenio; Cataldo, Alfredo

    2014-01-01

    OBJECTIVE To analyze the prevalence of depression in older adults and associated factors. METHODS Cross-sectional study using a stratified random sample of 621 individuals aged ≥ 60 from 27 family health teams in Porto Alegre, RS, Southern Brazil, between 2010 and 2012. Community health agents measured depression using the 15-item Geriatric Depression Scale. Scores of ≥ 6 were considered as depression and between 11 and 15 as severe depression. Poisson regression was used to search for independent associations of sociodemographic and self-perceived health with both depression and its severity. RESULTS The prevalence of depression was 30.6% and was significantly higher in women (35.9% women versus 20.9% men, p < 0.001). The variables independently associated with depression were: female gender (PR = 1.4, 95%CI 1.1;1.8); low education, especially illiteracy (PR = 1.8, 95%CI 1.2;2 6); regular self-rated health (OR = 2.2, 95%CI 1.6;3.0); and poor/very poor self-rated health (PR = 4.0, 95%CI 2.9;5.5). Except for education, the strength of association of these factors increases significantly in severe depression. CONCLUSIONS A high prevalence of depression was observed in the evaluations conducted by community health agents, professionals who are not highly specialized. The findings identified using the 15-item Geriatric Depression Scale in this way are similar to those in the literature, with depression more associated with low education, female gender and worse self-rated health. From a primary health care strategic point of view, the findings become still more relevant, indicating that community health agents could play an important role in identifying depression in older adults. PMID:25119932

  2. 77 FR 68102 - Foreign-Trade Zone 163-Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 163--Ponce, PR; Application for Subzone; Zimmer Manufacturing... Manufacturing BV located in Ponce, Puerto Rico. The application was submitted pursuant to the provisions of...

  3. Epidemiology of congenital heart disease in Brazil

    PubMed Central

    Pinto Júnior, Valdester Cavalcante; Branco, Klébia Magalhães P. Castello; Cavalcante, Rodrigo Cardoso; Carvalho Junior, Waldemiro; Lima, José Rubens Costa; de Freitas, Sílvia Maria; Fraga, Maria Nazaré de Oliveira; de Souza, Nayana Maria Gomes

    2015-01-01

    Introduction Congenital heart disease is an abnormality in the structure or cardiocirculatory function, occurring from birth, even if diagnosed later. It can result in intrauterine death in childhood or in adulthood. Accounted for 6% of infant deaths in Brazil in 2007. Objective To estimate underreporting in the prevalence of congenital heart disease in Brazil and its subtypes. Methods The calculations of prevalence were performed by applying coefficients, giving them function rates for calculations of health problems. The study makes an approach between the literature and the governmental registries. It was adopted an estimate of 9: 1000 births and prevalence rates for subtypes applied to births of 2010. Estimates of births with congenital heart disease were compared with the reports to the Ministry of Health and were studied by descriptive methods with the use of rates and coefficients represented in tables. Results The incidence in Brazil is 25,757 new cases/year, distributed in: North 2,758; Northeast 7,570; Southeast 10,112; South 3,329; and Midwest 1,987. In 2010, were reported to System of Live Birth Information of Ministry of Health 1,377 cases of babies with congenital heart disease, representing 5.3% of the estimated for Brazil. In the same period, the most common subtypes were: ventricular septal defect (7,498); atrial septal defect (4,693); persistent ductus arteriosus (2,490); pulmonary stenosis (1,431); tetralogy of Fallot (973); coarctation of the aorta (973); transposition of the great arteries (887); and aortic stenosis 630. The prevalence of congenital heart disease, for the year of 2009, was 675,495 children and adolescents and 552,092 adults. Conclusion In Brazil, there is underreporting in the prevalence of congenital heart disease, signaling the need for adjustments in the methodology of registration. PMID:26107454

  4. Arsenic occurrence in Brazil and human exposure.

    PubMed

    de Figueiredo, Bernardino Ribeiro; Borba, Ricardo Perobelli; Angélica, Rômulo Simões

    2007-04-01

    Environmental exposure to arsenic (As) in terms of public health is receiving increasing attention worldwide following cases of mass contamination in different parts of the world. However, there is a scarcity of data available on As geochemistry in Brazilian territory, despite the known occurrence of As in some of the more severely polluted areas of Brazil. The purpose of this paper is to discuss existing data on As distribution in Brazil based on recent investigations in three contaminated areas as well as results from the literature. To date, integrated studies on environmental and anthropogenic sources of As contamination have been carried out only in three areas in Brazil: (1) the Southeastern region, known as the Iron Quadrangle, where As was released into the drainage systems, soils and atmosphere as a result of gold mining; (2) the Ribeira Valley, where As occurs in Pb-Zn mine wastes and naturally in As-rich rocks and soils; (3) the Amazon region, including the Santana area, where As is associated with manganese ores mined over the last 50 years. Toxicological studies revealed that the populations were not exposed to elevated levels of As, with the As concentrations in surface water in these areas rarely exceeding 10 microg/L. Deep weathering of bedrocks along with formation of Fe/Al-enriched soils and sediments function as a chemical barrier that prevents the release of As into the water. In addition, the tropical climate results in high rates of precipitation in the northern and southeastern regions and, hence, the As contents of drinking water is diluted. Severe cases of human As exposure related to non-point pollution sources have not been reported in Brazil. However, increasing awareness of the adverse health effects of As will eventually lead to a more complete picture of the distribution of As in Brazil. PMID:17351814

  5. Arsenic occurrence in Brazil and human exposure.

    PubMed

    de Figueiredo, Bernardino Ribeiro; Borba, Ricardo Perobelli; Angélica, Rômulo Simões

    2007-04-01

    Environmental exposure to arsenic (As) in terms of public health is receiving increasing attention worldwide following cases of mass contamination in different parts of the world. However, there is a scarcity of data available on As geochemistry in Brazilian territory, despite the known occurrence of As in some of the more severely polluted areas of Brazil. The purpose of this paper is to discuss existing data on As distribution in Brazil based on recent investigations in three contaminated areas as well as results from the literature. To date, integrated studies on environmental and anthropogenic sources of As contamination have been carried out only in three areas in Brazil: (1) the Southeastern region, known as the Iron Quadrangle, where As was released into the drainage systems, soils and atmosphere as a result of gold mining; (2) the Ribeira Valley, where As occurs in Pb-Zn mine wastes and naturally in As-rich rocks and soils; (3) the Amazon region, including the Santana area, where As is associated with manganese ores mined over the last 50 years. Toxicological studies revealed that the populations were not exposed to elevated levels of As, with the As concentrations in surface water in these areas rarely exceeding 10 microg/L. Deep weathering of bedrocks along with formation of Fe/Al-enriched soils and sediments function as a chemical barrier that prevents the release of As into the water. In addition, the tropical climate results in high rates of precipitation in the northern and southeastern regions and, hence, the As contents of drinking water is diluted. Severe cases of human As exposure related to non-point pollution sources have not been reported in Brazil. However, increasing awareness of the adverse health effects of As will eventually lead to a more complete picture of the distribution of As in Brazil.

  6. Effects of Zn impurities on the electronic properties of Pr doped CaTiO 3

    NASA Astrophysics Data System (ADS)

    Zhu, Ailing; Wang, Jianchuan; Du, Yong; Zhao, Dongdong; Gao, Qiannan

    2012-03-01

    Microcosmic investigations of weak red-emitting materials are crucial for their further development and application. In this work, we have focused on the band structures and electronic properties of Pr mono- and (Zn, Pr) co-doped CaTiO 3 using density functional theory. Zn substitution for Ca or Ti tends to form clusters energetically with Pr substituting for Ca in CaTiO 3. In Pr mono-doped CaTiO 3, the O 2p→Ti 3d transition in CaTiO 3 host corresponds to the centered 330 nm excitation spectra. The gap states above the valence band of ∼1.30 eV and ∼2.06 eV are hybridized by Pr 4f, O 2p and Ti 3d orbitals. They are mainly due to Pr 4f orbitals in CaTiO 3:Pr. The former gap level is related to red emission at 614 nm due to 1D 2→ 3H 4 transition of Pr 3+ activator. The latter is related to the excitation spectra centered at 380 nm due to the low-lying Pr-to-mental intervalence charge transfer transitions (Pr 3+-O 2--Ti 4+⇌Pr 4+-O 2--Ti 3+). The band structures of (Zn, Pr) co-doped CaTiO 3 keep the similar gap levels to those in Pr mono-doped CaTiO 3. The incorporation of Zn brings out the two stronger localized gap states, which are hybridized by Pr 4f, O 2p and Ti 3d orbitals, in comparison with those in Pr mono-doped CaTiO 3. Therefore, when Zn impurities are added into Pr doped CaTiO 3, the present calculations visualize the two enhanced levels and the distorted structures around Pr.

  7. The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).

    PubMed

    Turnbaugh, Jessie A; Unterberger, Ursula; Saá, Paula; Massignan, Tania; Fluharty, Brian R; Bowman, Frederick P; Miller, Michael B; Supattapone, Surachai; Biasini, Emiliano; Harris, David A

    2012-06-27

    Prion propagation involves a templating reaction in which the infectious form of the prion protein (PrP(Sc)) binds to the cellular form (PrP(C)), generating additional molecules of PrP(Sc). While several regions of the PrP(C) molecule have been suggested to play a role in PrP(Sc) formation based on in vitro studies, the contribution of these regions in vivo is unclear. Here, we report that mice expressing PrP deleted for a short, polybasic region at the N terminus (residues 23-31) display a dramatically reduced susceptibility to prion infection and accumulate greatly reduced levels of PrP(Sc). These results, in combination with biochemical data, demonstrate that residues 23-31 represent a critical site on PrP(C) that binds to PrP(Sc) and is essential for efficient prion propagation. It may be possible to specifically target this region for treatment of prion diseases as well as other neurodegenerative disorders due to β-sheet-rich oligomers that bind to PrP(C).

  8. When and why women might suspend PrEP use according to perceived seasons of risk: implications for PrEP-specific risk-reduction counselling.

    PubMed

    Namey, Emily; Agot, Kawango; Ahmed, Khatija; Odhiambo, Jacob; Skhosana, Joseph; Guest, Greg; Corneli, Amy

    2016-09-01

    Oral pre-exposure prophylaxis (PrEP) using the antiretroviral drug emtricitabine/tenofovir disoproxil fumarate (Truvada) has been shown to dramatically reduce the risk of HIV acquisition for women at higher risk of infection if taken daily. Understanding when and why women would intentionally stop using an efficacious oral PrEP drug within the context of their 'normal' daily lives is essential for delivering effective PrEP risk-reduction counselling. As part of a larger study, we conducted 60 qualitative interviews with women at higher risk of HIV in Bondo, Kenya, and Pretoria, South Africa. Participants charted their sexual contacts over the previous six months, indicated whether they would have taken PrEP if available and discussed whether and why they would have suspended PrEP use. Nearly all participants said they would have used PrEP in the previous six months; half indicated they would have suspended PrEP use at some point. Participants' reasons for an extended break from PrEP were related to partnership dynamics (e.g., perceived low risk of a stable partner) and phases of life (e.g., trying to conceive). Life events (e.g., holidays and travel) could prompt shorter breaks in PrEP use. These circumstances may or may not correspond to actual contexts of lower risk, highlighting the importance of tailored PrEP risk-reduction counselling.

  9. PrEP in Europe – expectations, opportunities and barriers

    PubMed Central

    McCormack, Sheena Mary; Noseda, Veronica; Molina, Jean-Michel

    2016-01-01

    Introduction In contrast to the global trend showing a decline in new HIV infections, the number reported in the World Health Organization (WHO) region of Europe is increasing. Health systems are disparate, but even countries with free access to screening and treatment observe continuing high rates of new infections in key populations, notably men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is only available in France. This commentary describes the European epidemics and healthcare settings where PrEP could be delivered, how need might be estimated for MSM and the residual barriers to access. Discussion Health systems and government commitment to HIV prevention and care, both financial and political, differ considerably between the countries that make up Europe. A common feature is that funds for prevention are a small fraction of funds for care. Although care is generally good, access is limited in the middle-income countries of Eastern Europe and central Asia, and only 19% of people living with HIV received antiretroviral therapy in 2014. It is challenging to motivate governments or civil society to implement PrEP in the context of this unmet treatment need, which is driven by limited national health budgets and diminishing assistance from foreign aid. The high-income countries of Western Europe have hesitated to embrace PrEP for different reasons, initially due to key gaps in the evidence. Now that PrEP has been shown to be highly effective in European MSM in two randomized controlled trials, it is clear that the major barrier is the cost of the drug which is still on patent, although inadequate health systems and diminishing investment in civil society are also key challenges to overcome. Conclusions The momentum to implement PrEP in European countries is increasing and provides a welcome opportunity to expand and improve clinical services and civil society support focused on HIV and related infections including other sexually transmitted and

  10. Brazil to Join the European Southern Observatory

    NASA Astrophysics Data System (ADS)

    2010-12-01

    The Federative Republic of Brazil has yesterday signed the formal accession agreement paving the way for it to become a Member State of the European Southern Observatory (ESO). Following government ratification Brazil will become the fifteenth Member State and the first from outside Europe. On 29 December 2010, at a ceremony in Brasilia, the Brazilian Minister of Science and Technology, Sergio Machado Rezende and the ESO Director General, Tim de Zeeuw signed the formal accession agreement aiming to make Brazil a Member State of the European Southern Observatory. Brazil will become the fifteen Member State and the first from outside Europe. Since the agreement means accession to an international convention, the agreement must now be submitted to the Brazilian Parliament for ratification [1]. The signing of the agreement followed the unanimous approval by the ESO Council during an extraordinary meeting on 21 December 2010. "Joining ESO will give new impetus to the development of science, technology and innovation in Brazil as part of the considerable efforts our government is making to keep the country advancing in these strategic areas," says Rezende. The European Southern Observatory has a long history of successful involvement with South America, ever since Chile was selected as the best site for its observatories in 1963. Until now, however, no non-European country has joined ESO as a Member State. "The membership of Brazil will give the vibrant Brazilian astronomical community full access to the most productive observatory in the world and open up opportunities for Brazilian high-tech industry to contribute to the European Extremely Large Telescope project. It will also bring new resources and skills to the organisation at the right time for them to make a major contribution to this exciting project," adds ESO Director General, Tim de Zeeuw. The European Extremely Large Telescope (E-ELT) telescope design phase was recently completed and a major review was

  11. Solid-state reaction synthesis and characterization of PrB6 nanocrystals

    NASA Astrophysics Data System (ADS)

    Wei, Wei; Lihong, Bao; Yingjie, Li; Luomeng, Chao; Tegus, O.

    2015-04-01

    Crystalline PrB6 nanoparticles with the sizes ranging from 100~300 nm were synthesized by a solid-state reaction of Pr6O11/PrCl3 and NaBH4 in the temperature range of 1100~1200 °C. The crystal structure, component and morphology of the PrB6 nanoparticles were characterized by using X-ray diffraction, scanning electron microscopy and transmission electron microscopy. The results show that the particles crystallize in the CsCl structure type. The selected-area electron diffraction patterns reveal the particles have single-crystalline nature. XANES study shows that the Pr atoms in the PrB6 particles are in trivalent state even if the Pr atoms possess the mixed valence state in the raw material Pr6O11.

  12. AQUIFER PROTIST RESPONSE AND THE POTENTIAL FOR TCE BIOREMEDIATION WITH BURKHOLDERIA CEPACIA G4 PR1

    EPA Science Inventory

    The introduction of bacteria into the environment for bioremediation purposes (bioaugmentation) requires analysis and monitoring of the persistence and activity of microbial population for efficacy and risk assessment purposes. Burkholderia cepacia G4 PR123 and PR131 constitutive...

  13. [The influence of structural and organizational factors on the performance of primary health care in Belo Horizonte, Minas Gerais State, Brazil, according to nurses and managers].

    PubMed

    Turci, Maria Aparecida; Lima-Costa, Maria Fernanda; Macinko, James

    2015-09-01

    The aim of this study was to evaluate the performance of primary health care (PHC) in Belo Horizonte, Minas Gerais State, Brazil, using the Portuguese-language version of the Primary Health Care Assessment Tool among nurses and managers of family health teams. Total PHC score was 0.75 (good). The dimensions first contact (0.95), longitudinality (0.83), comprehensiveness (0.83), and coordination (0.78) performed the best. Family approach, community orientation, and access received the lowest scores (0.68, 0.56, and 0.45, respectively). Better PHC performance was associated with the following factors (p < 0.05): availability of health care equipment and other inputs (adjusted PR = 1.57), education and training for family health teams (PR = 1.44), a physician on duty for more than 30 hours per week (PR = 1.42), and presence of four or more teams per primary care unit (PR = 1.09). The results show the importance of structural and organizational factors for PHC performance and suggest that permanent evaluation can identify aspects that require quality improvement. PMID:26578018

  14. The prevalence of physical activity and its associated effects among students in the São Paulo public school network, Brazil.

    PubMed

    Silva, Leonardo José; Matsudo, Victor Keihan Rodrigues; Andrade, Douglas Roque; Azevedo, Mário; Ferrari, Gerson Luis de Moraes; Oliveira, Luis Carlos; Araújo, Timóteo Leandro; Matsudo, Sandra Marcela Mahecha

    2016-04-01

    The current study evaluated physical activity (PA) level and its associated effects among students in the public network of São Paulo, Brazil. A cross-sectional study was taken using a representative sample of students in São Paulo public school system. International Physical Activity Questionnaire determined PA level. Students who reported at least 300 minutes/week of PA were considered active. The independente variables were: gender, age, body mass index, education, region, recognition of the Agita São Paulo program. The prevalence of regular PA was 71.7%. Males (PR = 1.09, 95% CIs = 1.04 -1.15) at least 17 years old (PR = 1.16, 95% CIs 1.09-1.24) in their 3rd year of high school (PR = 1.20, 95% CIs = 1.12-1.29) who resided in the Midwest region (PR = 1.27, 95% CIs 1.16-1.38) were most likely to be active. Males at least 17 years old in their 3rd year of high school who lived in the Midwest and recognized the Agita São Paulo/Agita Galera program had higher levels of PA. São Paulo students presented a high level of PA. Moreover, males older than 17 years, attending their 3rd year of high school, who lived in the Midwest region, and recognized the Agita São Paulo/Agita Galera program were the most likely to be more active.

  15. Constitutive expression of pathogenesis-related proteins PR-1, GRP, and PR-S in tobacco has no effect on virus infection.

    PubMed

    Linthorst, H J; Meuwissen, R L; Kauffmann, S; Bol, J F

    1989-03-01

    Samsun NN tobacco cells were transformed with chimeric genes for pathogenesis-related (PR) proteins derived from genomic (PR-1a, GRP) or cDNA (PR-S) clones under the transcriptional control of the cauliflower mosaic virus 35S promoter. Regenerated plants were assayed by RNA and protein gel blotting, and plants showing high specific expression of the inserted genes were selected for self-pollination and seed formation. Inspection of second generation transformants showed that constitutive expression of PR-1a, GRP, and PR-S in tobacco in general does not have an effect on the phenotypic appearance of the plants or the expression of other endogenous PR genes. Furthermore, constitutive expression of the above genes does not affect the susceptibility of the plants to infection with tobacco mosaic virus or alfalfa mosaic virus.

  16. Near-yrast structure of {sup 149}Pr

    SciTech Connect

    Rzaca-Urban, T.; Urban, W.; Pinston, J. A.; Simpson, G. S.; Ahmad, I.

    2010-12-15

    The neutron-rich nucleus {sup 149}Pr has been studied by means of prompt and delayed {gamma}-ray spectroscopy using the EUROGAM2 and Gammasphere arrays of Ge detectors. New spins have been assigned to a previously reported band and it is interpreted as having a h{sub 11/2} proton structure, from a comparison with quasiparticle-rotor model calculations. The strength of octupole correlations in odd-Z nuclei of the region is discussed.

  17. Public Relations: Ketchum brands new product with innovative PR strategy.

    PubMed

    2006-01-01

    Novartis Pharmaceuticals tapped publis relations (PR) giant Ketchum earlier this year to spearhead a marketing campaign that would make its new U.S. Food and Drug Administration-approved prescription-based medication, Enablex, stand out among the crowd in over active bladder (OAB) treatment. OAB is a disorder that affects an estimated 33 million Americans making this treatment highly in demand with consumers and highly competitive with other pharmaceutical companies.

  18. Progress and limits of PrP gene selection policy.

    PubMed

    Dawson, Michael; Moore, Richard C; Bishop, Stephen C

    2008-01-01

    Classical scrapie has proved to be a notoriously difficult disease to control due to a poor understanding of its natural history. The recognition of disease risk linkage to PrP genotype has offered the prospect of a disease control strategy, viz. genotyping and selective breeding, novel to veterinary medicine when first considered in the 1990s. The UK Spongiform Encephalopathy Advisory Committee recommended the exploitation of this approach in a voluntary, national programme to control classical scrapie and protect the public against food-borne exposure to bovine spongiform encephalopathy, should the national flock have been exposed via contaminated feed. The National Scrapie Plan for Great Britain was launched in 2001 and uptake has been widespread throughout the purebreeding sector of the sheep industry, with membership peaking at over 12 000 flocks in 2006. A total of 700 000 rams from 90 breeds have been genotyped. A comparison of ram lambs born in 2002 with those in 2006 shows evident changes in PrP genotype frequencies which are predicted to be associated with a reduction in disease risk. Various concerns have been raised regarding possible unintended consequences of widespread selection on PrP genotype, including impacts on other performance traits and possible effects on inbreeding and genetic diversity. To date, these concerns appear to be unfounded, as no consistent associations have been found with performance traits, nor are there likely to be any detectable impacts on inbreeding in mainstream breeds. Currently, semen banks have been implemented in Great Britain to store samples from animals of all common PrP genotypes, should these genotypes be required in the future. Various strategies to minimise future disease risks are discussed in the paper.

  19. Transition Probabilities And Chiral Symmetry In 134Pr

    SciTech Connect

    Tonev, D.; De Angelis, G.; Gadea, A.; Axiotis, M.; Marginean, N.; Martines, T.; Napoli, D.R.; Prete, G.; Behera, B.R.; Rusu, C.; Petkov, P.; Dewald, A.; Pejovic, P.; Fitzler, A.; Moeller, O.; Zell, K.O.; Balabanski, D.; Bednarczyk, P.; Camera, F.; Paleni, A.

    2005-04-05

    Lifetime measurements in 134Pr were performed by means of the Recoil distance Doppler-shift and Doppler-shift attenuation methods using the multidetector array EUROBALL, in conjunction with the inner BGO ball. The derived B(E2) transition strengths within the two bands candidates for chiral partners behave differently with increasing spin while the corresponding B(M1) values have a similar behaviour within the experimental uncertainties.

  20. Public Relations: Ketchum brands new product with innovative PR strategy.

    PubMed

    2006-01-01

    Novartis Pharmaceuticals tapped publis relations (PR) giant Ketchum earlier this year to spearhead a marketing campaign that would make its new U.S. Food and Drug Administration-approved prescription-based medication, Enablex, stand out among the crowd in over active bladder (OAB) treatment. OAB is a disorder that affects an estimated 33 million Americans making this treatment highly in demand with consumers and highly competitive with other pharmaceutical companies. PMID:17048759

  1. Getting the Most PR for Your School. NHSC Occasional Paper Number 8.

    ERIC Educational Resources Information Center

    Welch, Sally R.

    All National Home Study Council (NHSC) schools need public relations (PR) programs that are focused on the success of the school's graduates and the educational rigor and quality of its instruction rather than on the school owner's personal success or the success/size of the school. PR can be handled by schools' marketing departments. PR programs…

  2. Dimerization and protease resistance: new insight into the function of PR-1

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The group 1 pathogenesis-related (PR-1) proteins have long been considered hallmarks of hypersensitive response/defense pathways in plants, but their biochemical functions are still obscure despite resolution of the NMR/X-ray structures of several PR-1-like proteins, including P14a (the prototype PR...

  3. PrP(C) signalling in neurons: from basics to clinical challenges.

    PubMed

    Hirsch, Théo Z; Hernandez-Rapp, Julia; Martin-Lannerée, Séverine; Launay, Jean-Marie; Mouillet-Richard, Sophie

    2014-09-01

    The cellular prion protein PrP(C) was identified over twenty-five years ago as the normal counterpart of the scrapie prion protein PrP(Sc), itself the main if not the sole component of the infectious agent at the root of Transmissible Spongiform Encephalopathies (TSEs). PrP(C) is a ubiquitous cell surface protein, abundantly expressed in neurons, which constitute the targets of PrP(Sc)-mediated toxicity. Converging evidence have highlighted that neuronal, GPI-anchored PrP(C) is absolutely required for prion-induced neuropathogenesis, which warrants investigating into the normal function exerted by PrP(C) in a neuronal context. It is now well-established that PrP(C) can serve as a cell signalling molecule, able to mobilize transduction cascades in response to interactions with partners. This function endows PrP(C) with the capacity to participate in multiple neuronal processes, ranging from survival to synaptic plasticity. A diverse array of data have allowed to shed light on how this function is corrupted by PrP(Sc). Recently, amyloid Aβ oligomers, whose accumulation is associated with Alzheimer's disease (AD), were shown to similarly instigate toxic events by deviating PrP(C)-mediated signalling. Here, we provide an overview of the various signal transduction cascades ascribed to PrP(C) in neurons, summarize how their subversion by PrP(Sc) or Aβ oligomers contributes to TSE or AD neuropathogenesis and discuss the ensuing clinical implications.

  4. Generation IV PR and PP Methods and Applications

    SciTech Connect

    Bari,R.A.

    2008-10-13

    This paper presents an evaluation methodology for proliferation resistance and physical protection (PR&PP) of Generation IV nuclear energy systems (NESs). For a proposed NES design, the methodology defines a set of challenges, analyzes system response to these challenges, and assesses outcomes. The challenges to the NES are the threats posed by potential actors (proliferant States or sub-national adversaries). The characteristics of Generation IV systems, both technical and institutional, are used to evaluate the response of the system and determine its resistance against proliferation threats and robustness against sabotage and terrorism threats. The outcomes of the system response are expressed in terms of six measures for PR and three measures for PP, which are the high-level PR&PP characteristics of the NES. The methodology is organized to allow evaluations to be performed at the earliest stages of system design and to become more detailed and more representative as design progresses. Uncertainty of results are recognized and incorporated into the evaluation at all stages. The results are intended for three types of users: system designers, program policy makers, and external stakeholders. Particular current relevant activities will be discussed in this regard. The methodology has been illustrated in a series of demonstration and case studies and these will be summarized in the paper.

  5. ER and PR signaling nodes during mammary gland development

    PubMed Central

    2012-01-01

    The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling stems from in vitro studies with hormone receptor-positive cell lines. They have shown that ER and PR regulate gene transcription either by binding to DNA response elements directly or via other transcription factors and recruiting co-regulators. In addition they cross-talk with other signaling pathways through nongenomic mechanisms. Mouse genetics combined with tissue recombination techniques have provided insights about the action of these two hormones in vivo. It has emerged that hormones act on a subset of mammary epithelial cells and relegate biological functions to paracrine factors. With regards to hormonal signaling in breast carcinomas, global gene expression analyses have led to the identification of gene expression signatures that are characteristic of ERα-positive tumors that have stipulated functional studies of hitherto poorly understood transcription factors. Here, we highlight what has been learned about ER and PR signaling nodes in these different systems and attempt to lay out in which way the insights may converge. PMID:22809143

  6. Molecular Cloning of HbPR-1 Gene from Rubber Tree, Expression of HbPR-1 Gene in Nicotiana benthamiana and Its Inhibition of Phytophthora palmivora.

    PubMed

    Khunjan, Uraiwan; Ekchaweng, Kitiya; Panrat, Tanate; Tian, Miaoying; Churngchow, Nunta

    2016-01-01

    This is the first report to present a full-length cDNA (designated HbPR-1) encoding a putative basic HbPR-1 protein from rubber tree (Hevea brasiliensis) treated with salicylic acid. It was characterized and also expressed in Nicotiana benthamiana using Agrobacterium-mediated transient gene expression system in order to investigate the role of HbPR-1 gene in rubber tree against its oomycete pathogen Phytopthora palmivora and to produce recombinant HbPR-1 protein for microbial inhibition test. The HbPR-1 cDNA was 647 bp long and contained an open reading frame of 492 nucleotides encoding 163 amino acid residues with a predicted molecular mass of 17,681 Da and an isoelectric point (pI) of 8.56, demonstrating that HbPR-1 protein belongs to the basic PR-1 type. The predicted 3D structure of HbPR-1 was composed of four α-helices, three β-sheets, seven strands, and one junction loop. Expression and purification of recombinant HbPR-1 protein were successful using Agrobacterium-mediated transient expression and one-step of affinity chromatography. Heterologous expression of HbPR-1 in N. benthamiana reduced necrosis areas which were inoculated with P. palmivora zoospores, indicating that the expressed HbPR-1 protein played an important role in plant resistance to pathogens. The purified recombinant HbPR-1 protein was found to inhibit 64% of P. palmivora zoospore germination on a water agar plate compared with control, suggesting that it was an antimicrobial protein against P. palmivora. PMID:27337148

  7. Molecular Cloning of HbPR-1 Gene from Rubber Tree, Expression of HbPR-1 Gene in Nicotiana benthamiana and Its Inhibition of Phytophthora palmivora

    PubMed Central

    Khunjan, Uraiwan; Ekchaweng, Kitiya; Panrat, Tanate; Tian, Miaoying; Churngchow, Nunta

    2016-01-01

    This is the first report to present a full-length cDNA (designated HbPR-1) encoding a putative basic HbPR-1 protein from rubber tree (Hevea brasiliensis) treated with salicylic acid. It was characterized and also expressed in Nicotiana benthamiana using Agrobacterium-mediated transient gene expression system in order to investigate the role of HbPR-1 gene in rubber tree against its oomycete pathogen Phytopthora palmivora and to produce recombinant HbPR-1 protein for microbial inhibition test. The HbPR-1 cDNA was 647 bp long and contained an open reading frame of 492 nucleotides encoding 163 amino acid residues with a predicted molecular mass of 17,681 Da and an isoelectric point (pI) of 8.56, demonstrating that HbPR-1 protein belongs to the basic PR-1 type. The predicted 3D structure of HbPR-1 was composed of four α-helices, three β-sheets, seven strands, and one junction loop. Expression and purification of recombinant HbPR-1 protein were successful using Agrobacterium-mediated transient expression and one-step of affinity chromatography. Heterologous expression of HbPR-1 in N. benthamiana reduced necrosis areas which were inoculated with P. palmivora zoospores, indicating that the expressed HbPR-1 protein played an important role in plant resistance to pathogens. The purified recombinant HbPR-1 protein was found to inhibit 64% of P. palmivora zoospore germination on a water agar plate compared with control, suggesting that it was an antimicrobial protein against P. palmivora. PMID:27337148

  8. Cytosolic PrP Can Participate in Prion-Mediated Toxicity

    PubMed Central

    Thackray, Alana M.; Zhang, Chang; Arndt, Tina

    2014-01-01

    ABSTRACT Prion diseases are characterized by a conformational change in the normal host protein PrPC. While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphatidylinositol anchor, topological variants of this protein can arise during its biosynthesis. Here we have generated Drosophila transgenic for cytosolic ovine PrP in order to investigate its toxic potential in flies in the absence or presence of exogenous ovine prions. While cytosolic ovine PrP expressed in Drosophila was predominantly detergent insoluble and showed resistance to low concentrations of proteinase K, it was not overtly detrimental to the flies. However, Drosophila transgenic for cytosolic PrP expression exposed to classical or atypical scrapie prion inocula showed a faster decrease in locomotor activity than similar flies exposed to scrapie-free material. The susceptibility to classical scrapie inocula could be assessed in Drosophila transgenic for panneuronal expression of cytosolic PrP, whereas susceptibility to atypical scrapie required ubiquitous PrP expression. Significantly, the toxic phenotype induced by ovine scrapie in cytosolic PrP transgenic Drosophila was transmissible to recipient PrP transgenic flies. These data show that while cytosolic PrP expression does not adversely affect Drosophila, this topological PrP variant can participate in the generation of transmissible scrapie-induced toxicity. These observations also show that PrP transgenic Drosophila are susceptible to classical and atypical scrapie prion strains and highlight the utility of this invertebrate host as a model of mammalian prion disease. IMPORTANCE During prion diseases, the host protein PrPC converts into an abnormal conformer, PrPSc, a process coupled to the generation of transmissible prions and neurotoxicity. While PrPC is principally a glycosylphosphatidylinositol-anchored membrane protein, the role of topological variants, such as cytosolic PrP, in prion-mediated toxicity and

  9. Doctoral education in nursing in Brazil.

    PubMed

    Rodrigues, Rosalina Aparecida Partezani; Erdmann, Alacoque Lorenzini; Silva, Isília Aparecida; Fernandes, Josicélia Dumet; Araújo, Thelma Leite; Vianna, Lucila Amaral Carneiro; Santos, Rosangela da Silva; Lopes, Marta Júlia Marques

    2008-01-01

    This study aimed to present the trajectory of doctoral education in nursing in Brazil from 1981 to 2004. A descriptive and analytical study was carried out, using documents available at the Brazilian Federal Agency for Support and Evaluation of Graduate Education, a body responsible for the recognition, evaluation and coordination of graduate studies in Brazil. Data analysis revealed that there are 13 doctoral courses in nursing, most of which are concentrated in the Southeast (69.2%), and that teaching and scientific production have been influenced by demographic and epidemiological transitions and by historical, social and political movements. Knowledge production is related to Nursing Care, Health Management and Practices and Theoretical Foundations of Care. Doctoral programs have prepared leaders in the fields of education, research and public policy development, in health institutions as well as in public policies, health institutions and governmental entities.

  10. Molecular Epidemiology of Oropouche Virus, Brazil

    PubMed Central

    Vasconcelos, Helena Baldez; Nunes, Márcio R.T.; Casseb, Lívia M.N.; Carvalho, Valéria L.; Pinto da Silva, Eliana V.; Silva, Mayra; Casseb, Samir M.M.

    2011-01-01

    Oropouche virus (OROV) is the causative agent of Oropouche fever, an urban febrile arboviral disease widespread in South America, with >30 epidemics reported in Brazil and other Latin American countries during 1960–2009. To describe the molecular epidemiology of OROV, we analyzed the entire N gene sequences (small RNA) of 66 strains and 35 partial Gn (medium RNA) and large RNA gene sequences. Distinct patterns of OROV strain clustered according to N, Gn, and large gene sequences, which suggests that each RNA segment had a different evolutionary history and that the classification in genotypes must consider the genetic information for all genetic segments. Finally, time-scale analysis based on the N gene showed that OROV emerged in Brazil ≈223 years ago and that genotype I (based on N gene data) was responsible for the emergence of all other genotypes and for virus dispersal. PMID:21529387

  11. John Banister: an Elizabethan surgeon in Brazil.

    PubMed

    Mello, Amílcar D'Avila de

    2011-03-01

    In Brazil's sixteenth-century history, very few references are made to health professionals. On the expedition of Edward Fenton, dispatched by the English Crown in 1582 to set up a trading post in Asia, was the famous barber-surgeon and physician John Banister. The naval squadron, diverted from its original route to repeat the feats of Sir Francis Drake, stopped over in Africa, crossed the Atlantic and anchored off the Santa Catarina coast in Brazil. In these waters, the expedition degenerated into piracy and returned unsuccessful to Europe. John Banister is considered the person who liberated English anatomy from mediaeval slavery, shedding upon it the light of the Renaissance. It was the first time that anyone of this importance in the area of health had visited these latitudes.

  12. The water-enhanced Brazil nut effect

    NASA Astrophysics Data System (ADS)

    Clement, C. P.; Pacheco-Martinez, H. A.; Swift, M. R.; King, P. J.

    2010-09-01

    It is well known that a large dense intruder may rise to the surface of a vibrated granular bed, the Brazil nut effect. In this paper we describe a water-enhanced Brazil nut effect which occurs when the vibrated granular bed is fully immersed in a liquid. We use a bed of glass beads immersed in water and monitor the behaviour of a large steel intruder as the system is vibrated vertically. To aid our understanding, we have developed numerical simulations to model this system and provide detailed information on the fluid and grain motion. The mechanism responsible for the rapid rise of the intruder is shown to be fluid-enhanced ratcheting rather than simple differential drag.

  13. Canine vector-borne diseases in Brazil

    PubMed Central

    Dantas-Torres, Filipe

    2008-01-01

    Canine vector-borne diseases (CVBDs) are highly prevalent in Brazil and represent a challenge to veterinarians and public health workers, since some diseases are of great zoonotic potential. Dogs are affected by many protozoa (e.g., Babesia vogeli, Leishmania infantum, and Trypanosoma cruzi), bacteria (e.g., Anaplasma platys and Ehrlichia canis), and helminths (e.g., Dirofilaria immitis and Dipylidium caninum) that are transmitted by a diverse range of arthropod vectors, including ticks, fleas, lice, triatomines, mosquitoes, tabanids, and phlebotomine sand flies. This article focuses on several aspects (etiology, transmission, distribution, prevalence, risk factors, diagnosis, control, prevention, and public health significance) of CVBDs in Brazil and discusses research gaps to be addressed in future studies. PMID:18691408

  14. The burden of osteoporosis in Brazil.

    PubMed

    Marinho, Bruna Coelho Galvão; Guerra, Luiza Paulino; Drummond, Juliana Beaudette; Silva, Barbara C; Soares, Maria Marta Sarquis

    2014-07-01

    Osteoporotic fractures impose severe physical, psychosocial, and financial burden both to the patient and the society. Studies on the prevalence of osteoporosis and fragility fractures in Brazil show a wide variation, due to differences in sample size, the population studied, and methodologies. Few studies have been conducted in Brazil about the cost-effectiveness analyses of different intervention options aimed at the diagnosis and treatment of osteoporosis. Investigation and treatment strategies based on cost-effectiveness and scientific evidence are essential in the preparation of public health policies with the ultimate goal of reducing the incidence of fractures and, consequently, the direct and indirect costs associated with them. This article reviews the Brazilian burden of osteoporosis in terms of the prevalence and fractures attributable to the disease, the costs related to the investigation and management, as well as the impact of osteoporosis on the population as a whole and on affected individuals.

  15. The legacy of monazite processing in Brazil.

    PubMed

    da Costa Lauria, Dejanira; Rochedo, Elaine R R

    2005-01-01

    The exploitation of natural resources containing naturally occurring radionuclides may lead to enhanced levels of radioactive isotope and enhanced potential for exposure to naturally occurring radionuclides in products, by-products, residues or wastes. Such resources include, for instance, monazite, the processing of which, in Brazil, generated a great amount of radioactive residues, being stored in buried concrete tanks, in temporary storage buildings and in sealed trenches. In addition, during the 1980s there were no radiological protection rules concerning the storage and transportation of these kinds of residues. Mineral radioactive residues were used as landfills and the residues of chemical processes contaminated floors and buildings. The decommissioning process and cleaning of old plants have generated tons of wastes that has been added to previously produced wastes. This paper reports and discusses the cycle of monazite in Brazil and its consequences in terms of site remediation and amount of wastes and residues generated and stored. PMID:15899906

  16. [Maternal mortality among black women in Brazil].

    PubMed

    Martins, Alaerte Leandro

    2006-11-01

    Every minute a woman dies in the world due to labor or complications of pregnancy. Maternal mortality is a public health problem in Brazil and affects the country's various regions unequally. Researchers agree that maternal death occurs mainly in women with lower income and less schooling. The racial issue emerges in the midst of socioeconomic issues. The analysis is hampered by the difficulty in understanding Brazil's official classification of race/color, which often impedes recording this information. Various Maternal Mortality Committees are applying the color item and reviewing their data. The current article analyzes various Maternal Mortality Committee reports, showing that the risk of maternal mortality is greater among black women (which encompasses two census categories, negra, or black, and parda, or brown), thus representing a major expression of social inequality. The article concludes with a review of political and technical recommendations to decrease maternal mortality.

  17. Biobanking and Privacy Law in Brazil.

    PubMed

    Dallari, Sueli Gandolfi; Castellaro, Felipe Angel Bocchi; Guerriero, Iara Coelho Zito

    2015-01-01

    This article analyzes the current regulatory framework for biobanking, genomic research, and protection of privacy in Brazil. It is divided in four parts. The first describes the biobanking context in Brazil and its evolution in recent years. In the second, the entire regulatory framework on biobanking and genomic research is analyzed. The third part focuses on the critical evaluation of this regulatory framework, specifically on some major ethical dilemmas in biobanking. The fourth part describes the characteristics of the Brazilian biobanking and human research governance system, known as the CEP/CONEP system. Finally, the conclusion summarizes the information in the article and its contribution to the study of the biobanking ethical challenges, especially the protection of privacy. It is highlighted that biobanking regulatory harmonization among countries is necessary, since it increases scientific possibilities that can come from broader cooperation among biobanks and several research centers on the national and international levels. PMID:26711412

  18. Occupation and urbanization of Roraima State, Brazil.

    PubMed

    Diniz, A

    1997-01-01

    The author examines settlement patterns and urbanization of the remote area of Roraima State, Brazil. "A survey conducted in the capital city, Boa Vista, provides information on migration histories and migrants' characteristics.... Current views of urbanization of the Amazon [region] are focused on the displacement factor that development and state geopolitics have upon rural settlements...." The author also suggests that more attention needs to be paid to the characteristics of migrants in the urban areas. (EXCERPT) PMID:12294841

  19. Occupation and urbanization of Roraima State, Brazil.

    PubMed

    Diniz, A

    1997-01-01

    The author examines settlement patterns and urbanization of the remote area of Roraima State, Brazil. "A survey conducted in the capital city, Boa Vista, provides information on migration histories and migrants' characteristics.... Current views of urbanization of the Amazon [region] are focused on the displacement factor that development and state geopolitics have upon rural settlements...." The author also suggests that more attention needs to be paid to the characteristics of migrants in the urban areas. (EXCERPT)

  20. Perspectives on bioenergy and biotechnology in Brazil.

    PubMed

    Pessoa-Jr, Adalberto; Roberto, Inês Conceição; Menossi, Marcelo; dos Santos, Raphael Revert; Filho, Sylvio Ortega; Penna, Thereza Christina Vessoni

    2005-01-01

    Brazil is one of the world's largest producers of alcohol from biomass at low cost and is responsible for more than 1 million direct jobs. In 1973, the Brazilian Program of Alcohol (Proalcool) stimulated the creation of a bioethanol industry that has led to large economic, social, and scientific improvements. In the year 1984, 94.5% of Brazil's cars used bioethanol as fuel. In 2003/2004, 350.3 million of sugarcane produced 24.2 million t of sugar and 14.4 billion L of ethanol for an average 4.3 million cars using ethanol. Since its inception, cumulative investment in Proalcool totals US$11 billion, and Brazil has saved US$27 billion in oil imports. The ethanol production industry from sugarcane gene-rates 152 times more jobs than would have been the case if the same amount of fuel was produced from petroleum, and the use of ethanol as a fuel is advantageous for environmental reasons. In 2003, one of the biggest Brazilian ethanol industries started consuming 50% of the residual sugarcane bagasse to produce electrical energy (60 MW), a new alternative use of bioenergy for the Brazilian market. Other technologies for commercial uses of bagasse are in development, such as in the production of natural fibers, sweeteners (glucose and xylitol), single-cell proteins, lactic acid, microbial enzymes, and many other products based on fermentations (submerged and semisolid). Furthermore, studies aimed at the increase in the biosynthesis of sucrose and, consequently, ethanol productivity are being conducted to understand the genetics of sugarcane. Although, at present, there remain technical obstacles to the economic use of some ethanol industry residues, several research projects have been carried out and useful data generated. Efficient utilization of ethanol industry residues has created new opportunities for new value-added products, especially in Brazil, where they are produced in high quantities.

  1. A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell lines.

    PubMed

    Jones, Daryl Rhys; Taylor, William Alexander; Bate, Clive; David, Monique; Tayebi, Mourad

    2010-01-01

    The development of antibodies effective in crossing the blood brain barrier (BBB), capable of accessing the cytosol of affected cells and with higher affinity for PrP(Sc) would be of paramount importance in arresting disease progression in its late stage and treating individuals with prion diseases. Antibody-based therapy appears to be the most promising approach following the exciting report from White and colleagues, establishing the "proof-of-principle" for prion-immunotherapy. After passive transfer, anti-prion antibodies were shown to be very effective in curing peripheral but not central rodent prion disease, due to the fact that these anti-prion antibodies are relatively large molecules and cannot therefore cross the BBB. Here, we show that an anti-prion antibody derived from camel immunised with murine scrapie material adsorbed to immunomagnetic beads is able to prevent infection of susceptible N2a cells and cure chronically scrapie-infected neuroblastoma cultures. This antibody was also shown to transmigrate across the BBB and cross the plasma membrane of neurons to target cytosolic PrP(C). In contrast, treatment with a conventional anti-prion antibody derived from mouse immunised with recombinant PrP protein was unable to prevent recurrence of PrP(Sc) replication. Furthermore, our camelid antibody did not display any neurotoxic effects following treatment of susceptible N2a cells as evidenced by TUNEL staining. These findings demonstrate the potential use of anti-prion camelid antibodies for the treatment of prion and other related diseases via non-invasive means.

  2. Dynamics of Cattle Production in Brazil.

    PubMed

    McManus, Concepta; Barcellos, Júlio Otávio Jardim; Formenton, Bruna Krummenauer; Hermuche, Potira Meirelles; Carvalho, Osmar Abílio de; Guimarães, RenatoFontes; Gianezini, Miguelangelo; Dias, Eduardo Antunes; Lampert, Vinícius do Nascimento; Zago, Daniele; Neto, José Braccini

    2016-01-01

    Movement of livestock production within a country or region has implications for genetics, adaptation, well-being, nutrition, and production logistics, particularly in continental-sized countries, such as Brazil. Cattle production in Brazil from 1977 to 2011 was spatialized, and the annual midpoint of production was calculated. Changes in the relative production and acceleration of production were calculated and spatialized using ARCGIS®. Cluster and canonical discriminant analyses were performed to further highlight differences between regions in terms of cattle production. The mean production point has moved from the Center of Minas Gerais State (in the southeast region) to the North of Goiás State (in the Midwest region). This reflects changes in environmental factors, such as pasture type, temperature and humidity. Acceleration in production in the northern region of Brazil has remained strong over the years. More recently, "traditional" cattle-rearing regions, such as the south and southeast, showed a reduction in growth rates as well as a reduction in herd size or internal migration over the period studied. These maps showed that this movement tends to be gradual, with few regions showing high acceleration or deceleration rates.

  3. Dynamics of Cattle Production in Brazil.

    PubMed

    McManus, Concepta; Barcellos, Júlio Otávio Jardim; Formenton, Bruna Krummenauer; Hermuche, Potira Meirelles; Carvalho, Osmar Abílio de; Guimarães, RenatoFontes; Gianezini, Miguelangelo; Dias, Eduardo Antunes; Lampert, Vinícius do Nascimento; Zago, Daniele; Neto, José Braccini

    2016-01-01

    Movement of livestock production within a country or region has implications for genetics, adaptation, well-being, nutrition, and production logistics, particularly in continental-sized countries, such as Brazil. Cattle production in Brazil from 1977 to 2011 was spatialized, and the annual midpoint of production was calculated. Changes in the relative production and acceleration of production were calculated and spatialized using ARCGIS®. Cluster and canonical discriminant analyses were performed to further highlight differences between regions in terms of cattle production. The mean production point has moved from the Center of Minas Gerais State (in the southeast region) to the North of Goiás State (in the Midwest region). This reflects changes in environmental factors, such as pasture type, temperature and humidity. Acceleration in production in the northern region of Brazil has remained strong over the years. More recently, "traditional" cattle-rearing regions, such as the south and southeast, showed a reduction in growth rates as well as a reduction in herd size or internal migration over the period studied. These maps showed that this movement tends to be gradual, with few regions showing high acceleration or deceleration rates. PMID:26814797

  4. "Health for All" in England and Brazil?

    PubMed

    Duncan, Peter; Bertolozzi, Maria Rita; Cowley, Sarah; Egry, Emiko Yoshikawa; Chiesa, Anna Maria; de Siqueira França, Francisco Oscar

    2015-01-01

    This article discusses the achievements and challenges that England and Brazil face in relation to their capacity to address inequalities in health through health promotion and public health policies. Using secondary data (policy texts and related documents), this article contextualizes, explains, and critically appraises health promotion and public health efforts for the reduction of inequalities in health in the 2 countries. A historic documentary analysis was undertaken, with hermeneutics as the methodological framework. The global economic crisis has prompted the so-called developed economies of Europe to reconsider their economic and social priorities. England represents a state facing this kind of challenge. Equally, Brazil is assuming new positions not only on the world stage but also in terms of the relationship it has with its citizens and the priorities it has for state welfare. The United Kingdom continues to finance a health care system allowing universal access in the form of the National Health Service, and state concern about the public health task of reducing inequalities has recently been underlined in policy. For Brazil, although there have been recent achievements related to population access to healthcare, challenges continue, especially with regard to the quality of care. PMID:26077860

  5. [Dengue and its vectors in Brazil].

    PubMed

    Dégallier, N; da Rosa, A P; Vasconcelos, P F; Figueiredo, L T; da Rosa, J F; Rodrigues, S G; da Rosa, E S

    1996-01-01

    History of dengue in Brazil is covered from the first citations in the XIXth century to the great outbreaks of the last ten years. DEN-1 and DEN-4 viruses have been isolated for the first time in 1982 during an epidemic in Boa Vista, Roraima State. In 1986-1987, epidemics of dengue type 1 covered an extended area from Rio de Janeiro/Sào Paulo States to the North East States of Brazil. During 1990-1991, dengue type 2 epidemics have been notified in the South East (Rio de Janeiro/São Paulo) and in some States of the interior of the country (Mato Grosso do Sul, Tocantins). DEN-1 virus was also circulating the same year in São Paulo and Minas Gerais States. Recently (1994), an important outbreak has been studied in Ceará State, where DEN-2 and DEN-1 viruses have been isolated. In Rio de Janeiro and Ceara (1990 and 1994, respectively), it is probably the succession of infections by DEN-1 and DEN-2 viruses which has caused many DHF/DSS cases. The urban vector has always been the mosquito Aedes aegypti, from which 4, 7 and 16 strains of DEN-4, DEN-1 and DEN-2 have been isolated, respectively. In Brazil, transovarial transmission of dengue viruses by this species has not yet been shown to occur in nature.

  6. The Devonian trilobites of Brazil: A summary

    NASA Astrophysics Data System (ADS)

    Carvalho, Maria da Gloria Pires de; Ponciano, Luiza Corral Martins de Oliveira

    2015-12-01

    Devonian trilobites are found in three major Paleozoic intracratonic basins of Brazil (Amazonas, Parnaíba, and Paraná). The trilobites represent the families Homalonotidae, Dalmanitidae, and Calmoniidae. The distribution of these taxa in the Brazilian territory is summarized here because of their remarkable scientific and historical importance, and a revised taxonomy and lithostratigraphy of the Devonian (Pragian - Famennian) trilobites from Brazil is presented, based on new research and recent literature. Homalonotids and dalmanitids are relatively cosmopolitan, whereas calmoniids are more endemic and seem to have been restricted to marine cold-waters of the southern hemisphere (Malvinokaffric Realm). Although the trilobites within the Brazilian intracratonic basins are approximately contemporaneous, they show various patterns of endemism and biogeographical affinities with other Malvinokaffric areas such as Bolivia, South Africa, and the Falkland (Malvinas) Islands. At family level, therefore, trilobite diversity from Brazil is comparatively low, which may indicate biogeographical filtering related to the distance and/or remoteness of the Brazilian basins from more open oceanic waters.

  7. The genesis of collective health in Brazil.

    PubMed

    Vieira-da-Silva, Ligia Maria; Pinell, Patrice

    2014-03-01

    During the 1970s in Brazil a social space directed towards health problems on the population level, called collective health, was created and institutionalised. To what extent did this Brazilian invention correspond to a specific socio-historical practice? The works published on this topic have considered social medicine as a homogeneous phenomenon without empirically studying the specificities of national experiences. To bridge this gap, a historical study on the genesis of collective health in Brazil was carried out based on Bourdieu's field theory. The interaction between the paths of the founders and the conditions of historical possibilities were researched through documentary and bibliographical sources, as well as through in-depth interviews of the founders. This social space originated from a meeting of agents with different social backgrounds but who interconnected, creating a structure that was independent of each agent considered individually. One of the components of this establishment was the joining of theoretical production and the implementation of health reforms that resulted in the organisation of a universal health system. This study attempts to show how the international political situation and the contradictions of the national crisis created a universe of possibilities, allowing for the genesis of this sui generis space in Brazil. PMID:24111568

  8. Cardiovascular Health in Brazil: Trends and Perspectives.

    PubMed

    Ribeiro, Antonio Luiz P; Duncan, Bruce B; Brant, Luisa C C; Lotufo, Paulo A; Mill, José Geraldo; Barreto, Sandhi M

    2016-01-26

    Brazil is a large country, with an evolving economy, but marked social inequalities. The population is formed by an admixture of native Brazilians, Europeans, and Africans; is predominantly urban; and faces rapid aging. Time trends related to health behaviors show a substantial reduction in smoking rates, but a rising prevalence of overweight and obesity, unhealthy eating habits, and insufficient physical activity. The high prevalence of hypertension and the increasing prevalence of diabetes mellitus are also causes for concern. Cardiovascular disease (CVD) has been the leading cause of mortality since the 1960s and has accounted for a substantial percentage of all hospitalizations. In 2011, CVD was responsible for 31% of all deaths, with ischemic heart disease (31%) and cerebrovascular diseases (30%) being the leading CVD causes. Despite an increase in the overall number of CVD deaths, the age-adjusted mortality rates for CVD declined 24% between 2000 and 2011. Health care delivered by Brazil's universal public health system, which focuses on primary prevention, has contributed to this achievement. However, the decline in age-adjusted mortality differs according to race, sex, and socioeconomic status with black individuals and lower-income populations sustaining the greatest impact of CVD, especially at younger ages. With one of the world's largest public health systems in terms of population coverage, Brazil has the means to implement actions to confront the high burden of CVD, focusing on health promotion and comprehensive care. Insufficient funding, low education levels, and social inequalities remain as the main barriers to be overcome. PMID:26811272

  9. Sustainable Rural Energy Development in Brazil

    SciTech Connect

    Ghandour, A.

    2005-01-01

    Under the Luz Para Todos ('Lights for All') Program, the Government of Brazil (GOB) seeks to provide basic electricity services to all its citizens by 2008. An estimated 2.5 million rural households (over 12 million Brazilians) currently lack electric service, with approximately 80% of them located in rural areas. Since many of these households are too geographically isolated to be connected to the national grid, they will receive distributed energy systems, and the government hopes to maximize the use of local renewable resources to service them. The National Renewable Energy Laboratory (NREL) is working with the GOB and a variety of local partners to identify and implement sustainable off-grid solutions to meet Brazil's rural energy needs. Focused in the Amazon region, these collaborative activities are, on one hand, using field-based activities to build local technical capacity and design replicable models for rural energy development, while on the other hand helping to develop the institutional structures that will be necessary to sustain distributed renewable energy development on a large-scale in Brazil.

  10. Dynamics of Cattle Production in Brazil

    PubMed Central

    McManus, Concepta; Barcellos, Júlio Otávio Jardim; Formenton, Bruna Krummenauer; Hermuche, Potira Meirelles; de Carvalho, Osmar Abílio; Guimarães, RenatoFontes; Gianezini, Miguelangelo; Dias, Eduardo Antunes; Lampert, Vinícius do Nascimento; Zago, Daniele; Neto, José Braccini

    2016-01-01

    Movement of livestock production within a country or region has implications for genetics, adaptation, well-being, nutrition, and production logistics, particularly in continental-sized countries, such as Brazil. Cattle production in Brazil from 1977 to 2011 was spatialized, and the annual midpoint of production was calculated. Changes in the relative production and acceleration of production were calculated and spatialized using ARCGIS®. Cluster and canonical discriminant analyses were performed to further highlight differences between regions in terms of cattle production. The mean production point has moved from the Center of Minas Gerais State (in the southeast region) to the North of Goiás State (in the Midwest region). This reflects changes in environmental factors, such as pasture type, temperature and humidity. Acceleration in production in the northern region of Brazil has remained strong over the years. More recently, “traditional” cattle-rearing regions, such as the south and southeast, showed a reduction in growth rates as well as a reduction in herd size or internal migration over the period studied. These maps showed that this movement tends to be gradual, with few regions showing high acceleration or deceleration rates. PMID:26814797

  11. Cardiovascular Health in Brazil: Trends and Perspectives.

    PubMed

    Ribeiro, Antonio Luiz P; Duncan, Bruce B; Brant, Luisa C C; Lotufo, Paulo A; Mill, José Geraldo; Barreto, Sandhi M

    2016-01-26

    Brazil is a large country, with an evolving economy, but marked social inequalities. The population is formed by an admixture of native Brazilians, Europeans, and Africans; is predominantly urban; and faces rapid aging. Time trends related to health behaviors show a substantial reduction in smoking rates, but a rising prevalence of overweight and obesity, unhealthy eating habits, and insufficient physical activity. The high prevalence of hypertension and the increasing prevalence of diabetes mellitus are also causes for concern. Cardiovascular disease (CVD) has been the leading cause of mortality since the 1960s and has accounted for a substantial percentage of all hospitalizations. In 2011, CVD was responsible for 31% of all deaths, with ischemic heart disease (31%) and cerebrovascular diseases (30%) being the leading CVD causes. Despite an increase in the overall number of CVD deaths, the age-adjusted mortality rates for CVD declined 24% between 2000 and 2011. Health care delivered by Brazil's universal public health system, which focuses on primary prevention, has contributed to this achievement. However, the decline in age-adjusted mortality differs according to race, sex, and socioeconomic status with black individuals and lower-income populations sustaining the greatest impact of CVD, especially at younger ages. With one of the world's largest public health systems in terms of population coverage, Brazil has the means to implement actions to confront the high burden of CVD, focusing on health promotion and comprehensive care. Insufficient funding, low education levels, and social inequalities remain as the main barriers to be overcome.

  12. [Reflections on drug policies in Brazil].

    PubMed

    de Andrade, Tarcísio Matos

    2011-12-01

    This article contains some reflections on drug policies in Brazil. In the first two chapters, taking the needle exchange programs (SEPs) as the starting point, the author discusses the trajectory of the Harm Reduction Policy in Brazil and the role played in it by the Department of STD, AIDS and Viral Hepatitis. The third chapter examines the actions developed by the National Coordination of Mental Health, Alcohol and Other Drugs and the Office of Drug Policies - SENAD, after the retraction of the Department of STD and AIDS from drug policies, as well as the introduction of PEAD and the "Crack Plan" in the country. In the fourth and fifth chapters the provisions of the current Brazilian policy on drugs and its limitations related mainly to the fragility of the Family Health Strategy are discussed, and some of the actions foreseen in the PEAD and the "Crack Plan" are critically analyzed. In the sixth chapter the author examines the effects of repression in the name of combating trafficking in the Brazilian policy on drugs having as background of the marginalization and social exclusion of users. Finally, some proposals are presented for the Alcohol and Drugs Policy in Brazil. PMID:22124907

  13. Brazil's Market for Trading Forest Certificates.

    PubMed

    Soares-Filho, Britaldo; Rajão, Raoni; Merry, Frank; Rodrigues, Hermann; Davis, Juliana; Lima, Letícia; Macedo, Marcia; Coe, Michael; Carneiro, Arnaldo; Santiago, Leonardo

    2016-01-01

    Brazil faces an enormous challenge to implement its revised Forest Code. Despite big losses for the environment, the law introduces new mechanisms to facilitate compliance and foster payment for ecosystem services (PES). The most promising of these is a market for trading forest certificates (CRAs) that allows landowners to offset their restoration obligations by paying for maintaining native vegetation elsewhere. We analyzed the economic potential for the emerging CRA market in Brazil and its implications for PES programs. Results indicate a potential market for trading 4.2 Mha of CRAs with a gross value of US$ 9.2±2.4 billion, with main regional markets forming in the states of Mato Grosso and São Paulo. This would be the largest market for trading forests in the world. Overall, the potential supply of CRAs in Brazilian states exceeds demand, creating an opportunity for additional PES programs to use the CRA market. This expanded market could provide not only monetary incentives to conserve native vegetation, but also environmental co-benefits by fostering PES programs focused on biodiversity, water conservation, and climate regulation. Effective implementation of the Forest Code will be vital to the success of this market and this hurdle brings uncertainty into the market. Long-term commitment, both within Brazil and abroad, will be essential to overcome the many challenges ahead.

  14. Food-fuel conflicts: the Brazil case

    SciTech Connect

    Rask, N.

    1981-01-01

    Brazil has decided to commit a significant part of its agricultural resources to the production of sugarcane and other crops to be processed into fuel grade alcohol. Concerns are already being raised about potential food-fuel conflicts, especially in the major food-sugarcane producing areas of the state of Sao Paulo and the sugarcane areas of northeast Brazil. The objective of this paper is to explore the dimensions of this emerging food-fuel issue in Brazil. The energy supply and use situation along with a brief description of the alcohol program are presented first. Current land use in relation to food and export crop production is presented next. This is followed by a description of the energy crops to be used for alcohol production. The paper concludes with an investigation of the food-fuel conflicts on a national and regional basis with the identification of some changes in program emphasis that will lessen the impact of the alcohol program on food supplies and prices.

  15. "Health for All" in England and Brazil?

    PubMed

    Duncan, Peter; Bertolozzi, Maria Rita; Cowley, Sarah; Egry, Emiko Yoshikawa; Chiesa, Anna Maria; de Siqueira França, Francisco Oscar

    2015-01-01

    This article discusses the achievements and challenges that England and Brazil face in relation to their capacity to address inequalities in health through health promotion and public health policies. Using secondary data (policy texts and related documents), this article contextualizes, explains, and critically appraises health promotion and public health efforts for the reduction of inequalities in health in the 2 countries. A historic documentary analysis was undertaken, with hermeneutics as the methodological framework. The global economic crisis has prompted the so-called developed economies of Europe to reconsider their economic and social priorities. England represents a state facing this kind of challenge. Equally, Brazil is assuming new positions not only on the world stage but also in terms of the relationship it has with its citizens and the priorities it has for state welfare. The United Kingdom continues to finance a health care system allowing universal access in the form of the National Health Service, and state concern about the public health task of reducing inequalities has recently been underlined in policy. For Brazil, although there have been recent achievements related to population access to healthcare, challenges continue, especially with regard to the quality of care.

  16. Brazil's Market for Trading Forest Certificates.

    PubMed

    Soares-Filho, Britaldo; Rajão, Raoni; Merry, Frank; Rodrigues, Hermann; Davis, Juliana; Lima, Letícia; Macedo, Marcia; Coe, Michael; Carneiro, Arnaldo; Santiago, Leonardo

    2016-01-01

    Brazil faces an enormous challenge to implement its revised Forest Code. Despite big losses for the environment, the law introduces new mechanisms to facilitate compliance and foster payment for ecosystem services (PES). The most promising of these is a market for trading forest certificates (CRAs) that allows landowners to offset their restoration obligations by paying for maintaining native vegetation elsewhere. We analyzed the economic potential for the emerging CRA market in Brazil and its implications for PES programs. Results indicate a potential market for trading 4.2 Mha of CRAs with a gross value of US$ 9.2±2.4 billion, with main regional markets forming in the states of Mato Grosso and São Paulo. This would be the largest market for trading forests in the world. Overall, the potential supply of CRAs in Brazilian states exceeds demand, creating an opportunity for additional PES programs to use the CRA market. This expanded market could provide not only monetary incentives to conserve native vegetation, but also environmental co-benefits by fostering PES programs focused on biodiversity, water conservation, and climate regulation. Effective implementation of the Forest Code will be vital to the success of this market and this hurdle brings uncertainty into the market. Long-term commitment, both within Brazil and abroad, will be essential to overcome the many challenges ahead. PMID:27050309

  17. The genesis of collective health in Brazil.

    PubMed

    Vieira-da-Silva, Ligia Maria; Pinell, Patrice

    2014-03-01

    During the 1970s in Brazil a social space directed towards health problems on the population level, called collective health, was created and institutionalised. To what extent did this Brazilian invention correspond to a specific socio-historical practice? The works published on this topic have considered social medicine as a homogeneous phenomenon without empirically studying the specificities of national experiences. To bridge this gap, a historical study on the genesis of collective health in Brazil was carried out based on Bourdieu's field theory. The interaction between the paths of the founders and the conditions of historical possibilities were researched through documentary and bibliographical sources, as well as through in-depth interviews of the founders. This social space originated from a meeting of agents with different social backgrounds but who interconnected, creating a structure that was independent of each agent considered individually. One of the components of this establishment was the joining of theoretical production and the implementation of health reforms that resulted in the organisation of a universal health system. This study attempts to show how the international political situation and the contradictions of the national crisis created a universe of possibilities, allowing for the genesis of this sui generis space in Brazil.

  18. Four new species of Cerambycidae (Coleoptera) from Bolivia and Brazil.

    PubMed

    Galileo, Maria Helena M; Martins, Ubirajara R; Santos-Silva, Antonio

    2015-01-01

    Four new species of Cerambycidae are described: Sphaerion iuasanga (Elaphidiini), Glypthaga arena, Hypsioma albosericea (Onciderini) from Bolivia (Santa Cruz), and Hesycha jataiensis (Onciderini) from Brazil. PMID:26250045

  19. Dangerous liaison: sexually transmitted allergic reaction to Brazil nuts.

    PubMed

    Bansal, A S; Chee, R; Nagendran, V; Warner, A; Hayman, G

    2007-01-01

    Brazil nuts are the second most frequent cause of nut allergy in the United Kingdom. We report the case of a 20-year-old woman with documented Brazil nut allergy who developed widespread urticaria and mild dyspnea after intercourse with her boyfriend who had earlier consumed Brazil nuts. Skin prick testing with the boyfriend's semen after Brazil nut consumption confirmed significant reactivity whereas a sample before nut consumption was negative. We believe this to be the first case of a sexually transmitted allergic reaction.

  20. Four new species of Cerambycidae (Coleoptera) from Bolivia and Brazil.

    PubMed

    Galileo, Maria Helena M; Martins, Ubirajara R; Santos-Silva, Antonio

    2015-07-13

    Four new species of Cerambycidae are described: Sphaerion iuasanga (Elaphidiini), Glypthaga arena, Hypsioma albosericea (Onciderini) from Bolivia (Santa Cruz), and Hesycha jataiensis (Onciderini) from Brazil.

  1. [Aspects of progesterone receptor (PR) activity regulation - impact on breast cancer progression].

    PubMed

    Piasecka, Dominika; Składanowski, Andrzej C; Kordek, Radzisław; Romańska, Hanna M; Sądej, Rafał

    2015-01-01

    Progesterone receptor (PR) and its specific ligand play a key role in development and physiology of mammary gland. The role of PR in initiation and progression of breast carcinoma (BCa) is unquestionable, although molecular mechanism of PR action is complex and not fully understood. It is known that increased risk of breast cancer is associated with progestin-based (synthetic ligands of progesterone) hormonal contraception or hormone replacement therapies. It is estimated that ER/PR-positive tumours represent approximately 50-70% of all BCa cases, and the loss of PR is associated with resistance to hormonal therapy and increased tumour invasiveness. In classical, genomic signalling pathway cytoplasmic PR, following ligand binding, translocates to the nucleus and regulates expression of genes with the PRE sequence. PR is also involved in a large number of alternative, non-genomic signalling cascades, e.g. PR is able to activate MAPK and PI3K/AKT pathways, which leads to regulation of gene expression. The cross-talk between PR and Growth Factors Receptors (GFR) results in progesterone-independent activation of PR as well as PR-regulated GFR expression and activation. Growth factors signalling promotes formation of a pool of hypersensitive PR responsive to even very low ligand concentration. Transcriptional activity of PR as well as its dynamic impact on processes such as cell migration and adhesion are crucial for BCa progression. Further studies of multifaceted mechanisms of PR action may contribute to new PR-targeting therapeutic strategies for breast cancer patients. PMID:26689013

  2. [Postgraduate programs in nursing in Brazil and in the northeast of Brazil].

    PubMed

    Rodrigues, Rosalina Aparecida Partezani; Erdmann, Alacoque Lorenzini; Fernandes, Josicélia Dumêt; de Araújo, Thelma Leite

    2007-03-01

    This descriptive-exploratory study aimed at describing the current situation of postgraduate programs in nursing in Brazil, particularly in the Northeast of Brazil, in terms of trends and expansion perspectives. Statistical data of 2003 were collected using registration tool on Stricto Sensu Postgraduate Programs in Nursing, made available by official research-sponsoring agencies Coordenation for the Improvement of Undergraduate Level Personnel (CAPES) and National Council for Scientific and Technological Development (CNPq). The results indicated extensive asymmetriesin the Brazilian Post-Graduation System, showing that the expansion of postgraduate programs in nursing in the Northeast of Brazil results from the response capacity to the official demands of the present national post-graduation system.

  3. Knowledge is Power! Increased Provider Knowledge Scores Regarding Pre-exposure Prophylaxis (PrEP) are Associated with Higher Rates of PrEP Prescription and Future Intent to Prescribe PrEP.

    PubMed

    Blumenthal, Jill; Jain, Sonia; Krakower, Douglas; Sun, Xiaoying; Young, Jason; Mayer, Kenneth; Haubrich, Richard

    2015-05-01

    The FDA approval of emtricitabine/tenofovir disoproxil fumarate for pre-exposure prophylaxis (PrEP) in 2012 has raised questions about the delivery of PrEP in a real-world setting. iPad-based questionnaires were given to providers at conferences in California and New York to assess knowledge, experience and attitudes regarding PrEP in HIV and non-HIV providers. HIV provider status was defined either by self-identification or by having greater than 5 years of HIV care experience. Knowledge scores were the sum of correct answers from five PrEP knowledge questions. Univariate analyses used t-test to compare knowledge scores and Fisher's exact test for past or future PrEP prescription between HIV and non-HIV providers. Multivariable linear or logistic regression models were used to assess factors associated with the outcomes. Of 233 respondents, the mean age was 40 years, 59 % were White, 59 % were physicians and 52 % were HIV providers. In univariate analysis, mean PrEP knowledge scores (max 5) were significantly higher for HIV providers (2.8 versus 2.2; p < 0.001), age > 41 (mean 2.8 versus 2.3; p = 0.004), White race (2.7 versus 2.2; p = 0.026) and participants in the New York region (3.0 versus 2.3; p < 0.001). In a multivariable model of knowledge scores, all but age remained significant. Among 201 potential prescribers, the rate of prior PrEP prescription was higher among HIV providers than non-HIV providers (34 versus 9 %; p < 0.001) and by knowledge score, but the association with provider status was no longer significant in multivariable analysis that controlled for knowledge. Intent to prescribe PrEP in the future was high for all provider types (64 %) and was associated with knowledge scores in multivariable analysis. The most common concerns about PrEP (>40 % of providers) were drug toxicities, development of resistance and patient adherence to follow-up; 32 % identified risk compensation as a concern. HIV providers had significantly greater PrEP knowledge

  4. High Blood Pressure among Students in Public and Private Schools in Maceió, Brazil

    PubMed Central

    Ferreira, Haroldo S.; Lúcio, Glícia Maris A.; Assunção, Monica L.; Silva, Bárbara Coelho V.; Oliveira, Juliana S.; Florêncio, Telma Maria M. T.; Geraldes, Amandio Aristides R.; Horta, Bernardo L.

    2015-01-01

    The prevalence of hypertension in childhood is increasing, and investigation of its distribution is important for planning timely interventions. This study assessed the prevalence of high blood pressure (HBP) and associated factors in students between 9 and 11 years of age enrolled in public and private schools in Maceió, Brazil. A cross-sectional study was performed in a probabilistic sample of students (10.3 ± 0.5 years). The students were selected from a systematic sampling of 80 schools (40 public and 40 private). To maintain similar proportions of students existing in public and private schools in Maceió, 21 and 14 students were randomly selected from each public and private school, respectively. The prevalence ratio (PR) was estimated using Poisson regression. A total of 1,338 students were evaluated (800 from public schools and 538 from private schools). No differences were observed between school types in terms of student age and gender (p > 0.05). The prevalence of obesity (19.9% vs. 9.0%; PR = 2.2; 95% CI = 1.67–2.92) and hypertension (21.2% vs. 11.4%; PR = 1.86; 95% CI = 1.45–2.40) were higher in private schools. The association between high blood pressure and type of school (public or private) remained statistically significant even after adjustment for obesity (PR = 1.53; 95% CI = 1.19–1.97). In conclusion: (a) students from private schools have higher socioeconomic status, BMI, and HBP prevalence compared to those of public school; (b) among the evaluated students, the prevalence of obesity only partially explained the higher prevalence of high blood pressure among students from private schools. Other factors related to lifestyle of children from private schools may explain the higher prevalence of HBP. This results show the need to implement measures to promote healthy lifestyles in the school environment, since children with HBP are more likely to become hypertensive adults. Therefore, early detection and intervention in children with HBP

  5. The problems of nutrition in Brazil.

    PubMed

    Sanders, T G

    1982-01-01

    Low income is the factor most often associated with the existence of malnutrition. Malnutrition in Brazil is more frequently found among Brazilians with less than 2 minimum salaries/family and who live in the less developed parts of the country. In 1976, 59.2% of urban residents earned 2 or less minimum salaries. A study found that those rural residents engaged in agriculture on their own or someone else's property were better paid than those who live from salaried labor alone; temporary salaried workers are the largest rural class in Brazil and have the lowest levels of nutrition. In urban areas the informal sector represent the lowest nutrition level group. The issue of food consumption by the lower classes is linked to 4 aspects of Brazilian development: 1) structure of food production, 2) distribution of income, 3) government attempts to influence prices and marketing systems, and 4) the role of government food supplementation programs. Brazil suffers today from unbalanced growth among its various economic sectors and regions, inequitable income distribution, and inadequate public services. The misconception of the necessity of a large industrial base for development resulted in the neglect of the rural sector and thus higher malnutrition. Recent regulatory efforts by the government have begun to increase rural production, but production of agricultural exports has increased at a much more rapid pace than that of domestic food commodities. Small farmers have not taken advantage of new financial opportunities offered by the government to balance production levels because: 1) banks do not have enough for the demand, 2) access to the small producer of foods is difficult, and 3) the present hesitation to risk his few possessions. The largest percentage of income in Brazil goes to the richest classes and the economy is oriented towards meeting the demands of the more prosperous classes. The government's program of minimum support prices has not been successful in

  6. The problems of nutrition in Brazil.

    PubMed

    Sanders, T G

    1982-01-01

    Low income is the factor most often associated with the existence of malnutrition. Malnutrition in Brazil is more frequently found among Brazilians with less than 2 minimum salaries/family and who live in the less developed parts of the country. In 1976, 59.2% of urban residents earned 2 or less minimum salaries. A study found that those rural residents engaged in agriculture on their own or someone else's property were better paid than those who live from salaried labor alone; temporary salaried workers are the largest rural class in Brazil and have the lowest levels of nutrition. In urban areas the informal sector represent the lowest nutrition level group. The issue of food consumption by the lower classes is linked to 4 aspects of Brazilian development: 1) structure of food production, 2) distribution of income, 3) government attempts to influence prices and marketing systems, and 4) the role of government food supplementation programs. Brazil suffers today from unbalanced growth among its various economic sectors and regions, inequitable income distribution, and inadequate public services. The misconception of the necessity of a large industrial base for development resulted in the neglect of the rural sector and thus higher malnutrition. Recent regulatory efforts by the government have begun to increase rural production, but production of agricultural exports has increased at a much more rapid pace than that of domestic food commodities. Small farmers have not taken advantage of new financial opportunities offered by the government to balance production levels because: 1) banks do not have enough for the demand, 2) access to the small producer of foods is difficult, and 3) the present hesitation to risk his few possessions. The largest percentage of income in Brazil goes to the richest classes and the economy is oriented towards meeting the demands of the more prosperous classes. The government's program of minimum support prices has not been successful in

  7. HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

    PubMed

    Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

    2016-08-01

    One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

  8. HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

    PubMed

    Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

    2016-08-01

    One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

  9. Long-term evolution of the western South Atlantic passive continental margin in a key area of SE Brazil revealed by thermokinematic numerical modeling using the software code Pecube

    NASA Astrophysics Data System (ADS)

    Stippich, Christian; Krob, Florian; Glasmacher, Ulrich A.; Hackspacher, Peter C.

    2016-04-01

    The aim of the research is to quantify the long-term evolution of the western South Atlantic passive continental margin (SAPCM) in SE-Brazil. Excellent onshore outcrop conditions and extensive pre-rift to post-rift archives between São Paulo and Laguna allow a high precision quantification of exhumation, and rock uplift rates, influencing physical parameters, long-term acting forces, and process-response systems. Research will integrate published1 and partly published thermochronological data from Brazil, and test lately published new concepts on causes of long-term landscape and lithospheric evolution in southern Brazil. Six distinct lithospheric blocks (Laguna, Florianópolis, Curitiba, Ilha Comprida, Peruibe and Santos), which are separated by fracture zones1 are characterized by individual thermochronological age spectra. Furthermore, the thermal evolution derived by numerical modeling indicates variable post-rift exhumation histories of these blocks. In this context, we will provide information on the causes for the complex exhumation history of the Florianópolis, and adjacent blocks. The climate-continental margin-mantle coupled process-response system is caused by the interaction between endogenous and exogenous forces, which are related to the mantle-process driven rift - drift - passive continental margin evolution of the South Atlantic, and the climate change since the Early/Late Cretaceous climate maximum. Special emphasis will be given to the influence of long-living transform faults such as the Florianopolis Fracture Zone (FFZ) on the long-term topography evolution of the SAPCM's. A long-term landscape evolution model with process rates will be achieved by thermo-kinematic 3-D modeling (software code PECUBE2,3 and FastScape4). Testing model solutions obtained for a multidimensional parameter space against the real thermochronological and geomorphological data set, the most likely combinations of parameter rates, and values can be constrained. The

  10. PrP{sup C} displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrP{sup C} knockout mice

    SciTech Connect

    Bertuchi, Fernanda R.; Bourgeon, Dominique M.G.; Landemberger, Michele C.; Martins, Vilma R.; Cerchiaro, Giselle

    2012-02-03

    Highlights: Black-Right-Pointing-Pointer PrP{sup C} in solution acts as a radical scavenger. Black-Right-Pointing-Pointer PrP{sup C} reduces hydrogen peroxide toxicity in astrocytes. Black-Right-Pointing-Pointer Increase in ROS disrupted the cell cycle in the PrP{sup C}-knockout astrocytes. Black-Right-Pointing-Pointer PrP{sup C} prevents the cell death independently of an SOD-like activity. -- Abstract: The PrP{sup C} protein, which is especially present in the cellular membrane of nervous system cells, has been extensively studied for its controversial antioxidant activity. In this study, we elucidated the free radical scavenger activity of purified murine PrP{sup C} in solution and its participation as a cell protector in astrocytes that were subjected to treatment with an oxidant. In vitro and using an EPR spin-trapping technique, we observed that PrP{sup C} decreased the oxidation of the DMPO trap in a Fenton reaction system (Cu{sup 2+}/ascorbate/H{sub 2}O{sub 2}), which was demonstrated by approximately 70% less DMPO/OH{sup {center_dot}}. In cultured PrP{sup C}-knockout astrocytes from mice, the absence of PrP{sup C} caused an increase in intracellular ROS (reactive oxygen species) generation during the first 3 h of H{sub 2}O{sub 2} treatment. This rapid increase in ROS disrupted the cell cycle in the PrP{sup C}-knockout astrocytes, which increased the population of cells in the sub-G1 phase when compared with cultured wild-type astrocytes. We conclude that PrP{sup C} in solution acts as a radical scavenger, and in astrocytes, it is essential for protection from oxidative stress caused by an external chemical agent, which is a likely condition in human neurodegenerative CNS disorders and pathological conditions such as ischemia.

  11. PrP mRNA and protein expression in brain and PrP(c) in CSF in Creutzfeldt-Jakob disease MM1 and VV2.

    PubMed

    Llorens, Franc; Ansoleaga, Belén; Garcia-Esparcia, Paula; Zafar, Saima; Grau-Rivera, Oriol; López-González, Irene; Blanco, Rosi; Carmona, Margarita; Yagüe, Jordi; Nos, Carlos; Del Río, José Antonio; Gelpí, Ellen; Zerr, Inga; Ferrer, Isidre

    2013-01-01

    Creutzfeldt-Jakob disease (CJD) is a heterogenic neurodegenerative disorder associated with abnormal post-translational processing of cellular prion protein (PrP(c)). CJD displays distinctive clinical and pathological features which correlate with the genotype at the codon 129 (methionine or valine: M or V respectively) in the prion protein gene and with size of the protease-resistant core of the abnormal prion protein PrP(sc) (type 1: 20/21 kDa and type 2: 19 kDa). MM1 and VV2 are the most common sporadic CJD (sCJD) subtypes. PrP mRNA expression levels in the frontal cortex and cerebellum are reduced in sCJD in a form subtype-dependent. Total PrP protein levels and PrP(sc) levels in the frontal cortex and cerebellum accumulate differentially in sCJD MM1 and sCJD VV2 with no relation between PrP(sc) deposition and spongiform degeneration and neuron loss, but with microgliosis, and IL6 and TNF-α response. In the CSF, reduced PrP(c), the only form present in this compartment, occurs in sCJD MM1 and VV2. PrP mRNA expression is also reduced in the frontal cortex in advanced stages of Alzheimer disease, Lewy body disease, progressive supranuclear palsy, and frontotemporal lobe degeneration, but PrP(c) levels in brain varies from one disease to another. Reduced PrP(c) levels in CSF correlate with PrP mRNA expression in brain, which in turn reflects severity of degeneration in sCJD.

  12. Suppression of superconductivity with Pr substitution in Nd 1- xPr xBaCaCu 3O 7 system

    NASA Astrophysics Data System (ADS)

    Awana, V. P. S.; Cardoso, Claudio A.; de Lima, O. F.; Singh, Rajvir; Narlikar, A. V.; Yelon, W. B.; Malik, S. K.

    1999-05-01

    The structural, superconducting and magnetic properties of Nd 1- xPr xBaCaCu 3O 7 system with x=0.0, 0.10, 0.25, 0.35, 0.50, 0.75 and 1.0 have been investigated. X-ray diffraction results reveal that Pr substitutes isostructurally in NdBaCaCu 3O 7 (Nd:1113) superconductor with complete solubility. The superconducting transition temperature ( Tc), measured by ac susceptibility technique, decreases with increasing x. However, suppression of Tc with increasing Pr substitution is less in Nd:1113 superconductor compared to that reported for Nd 1- xPr xBa 2Cu 3O 7 system. Interestingly, in the fully Pr substituted compounds of the above series, i.e., in PrBaCaCu 3O 7 and PrBa 2Cu 3O 7, the Pr moments order antiferromagnetically with TN of 10 and 17 K, respectively. The present results along those reported earlier [V.P.S. Awana, J. Horvat, S.X. Dou, A. Sedky, A.V. Narlikar, J. Magn. Magn. Mater., 182 (1998) L280; V.P.S. Awana, S.X. Dou, S.K. Malik, Rajvir Singh, A.V. Narlikar, D.A. Landinez Tellez, J.M. Ferreira, J. Albino Aguiar, S. Uma, E. Gmelin, W.B. Yelon, J. Magn. Magn. Mater., 187 (1998) 192], clearly suggest that there is a correlation between the Tc suppression due to Pr and the magnetic ordering temperature of the fully substituted Pr moments in these systems. The TN may be taken to be a measure of the strength of hybridization between the Pr-4f electrons with Cu-O conduction band, and hence a lower TN may imply a less deleterious effect on superconductivity.

  13. 76 FR 30195 - Brazil: Competitive Factors in Brazil Affecting U.S. and Brazilian Agricultural Sales in Selected...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... Brazil, including recent trends in production, consumption, and trade; 2. An overview of U.S. and... production, transportation and marketing infrastructure, technology, exchange rates, domestic support,...

  14. The thermodynamic characteristics of vaporization in the NaI-PrI3 system

    NASA Astrophysics Data System (ADS)

    Motalov, V. B.; Kudin, L. S.; Markus, T.

    2009-05-01

    The vaporization of the NaI-PrI3 quasi-binary system was studied by high-temperature mass spectrometry over the whole concentration range. At 623-994 K, saturated vapor contained not only (NaI) n and (PrI3) n molecules ( n = 1, 2) and Na+(NaI) n ( n = 0-4) and I-(PrI3) n ( n = 1-2) ions but also mixed molecular and ionic associates recorded for the first time (NaPrI4, Na2PrI5, NaPrI{3/+}, Na2PrI{4/+}, Na3PrI{5/+}, Na4PrI{6/+}, NaPrI{5/-}, and NaPr2I{8/-}). The partial vapor pressures of molecules were calculated, and the equilibrium constants of the dissociation of neutral and charged associates were measured. The enthalpies of molecular and ion-molecular reactions were determined, and the enthalpies of formation of gaseous molecules and ions were obtained.

  15. Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.

    PubMed

    Shao, Jia; Choe, Vitnary; Cheng, Haili; Tsai, Yien Che; Weissman, Allan M; Luo, Shiwen; Rao, Hai

    2014-01-01

    Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrPSc can trigger pathogenic events. How levels of PrP are regulated is poorly understood. Human PrP is known to be degraded by the proteasome, but the specific proteolytic pathway responsible for PrP destruction remains elusive. Here, we demonstrate that the ubiquitin ligase gp78, known for its role in protein quality control, is critical for unglycosylated PrP ubiquitylation and degradation. Furthermore, C-terminal sequences of PrP protein are crucial for its ubiquitylation and degradation. Our study reveals the first ubiquitin ligase specifically involved in prion protein PrP degradation and PrP sequences crucial for its turnover. Our data may lead to a new avenue to control PrP level and pathogenesis. PMID:24714645

  16. Control of interfacial properties of Pr-oxide/Ge gate stack structure by introduction of nitrogen

    NASA Astrophysics Data System (ADS)

    Kato, Kimihiko; Kondo, Hiroki; Sakashita, Mitsuo; Nakatsuka, Osamu; Zaima, Shigeaki

    2011-06-01

    We have demonstrated the control of interfacial properties of Pr-oxide/Ge gate stack structure by the introduction of nitrogen. From C- V characteristics of Al/Pr-oxide/Ge 3N 4/Ge MOS capacitors, the interface state density decreases without the change of the accumulation capacitance after annealing. The TEM and TED measurements reveal that the crystallization of Pr-oxide is enhanced with annealing and the columnar structure of cubic-Pr 2O 3 is formed after annealing. From the depth profiles measured using XPS with Ar sputtering for the Pr-oxide/Ge 3N 4/Ge stack structure, the increase in the Ge component is not observed in a Pr-oxide film and near the interface between a Pr-oxide film and a Ge substrate. In addition, the N component segregates near the interface region, amorphous Pr-oxynitride (PrON) is formed at the interface. As a result, Pr-oxide/PrON/Ge stacked structure without the Ge-oxynitride interlayer is formed.

  17. Purification and Fibrillation of Full-Length Recombinant PrP

    PubMed Central

    Makarava, Natallia; Baskakov, Ilia V.

    2013-01-01

    Misfolding and aggregation of prion protein (PrP) is related to several neurodegenerative diseases in humans such as Creutzfeldt–Jacob disease, fatal familial insomnia, and Gerstmann–Straussler–Sheinker disease. Certain applications in prion area require recombinant PrP of high purity and quality. Here, we report an experimental procedure for expression and purification of full-length mammalian PrP. This protocol has been proved to yield PrP of extremely high purity that lacks PrP adducts, which are normally generated as a result of spontaneous oxidation or degradation. We also describe methods for the preparation of amyloid fibrils from recombinant PrP in vitro. Recombinant PrP fibrils can be used as a noninfectious synthetic surrogate of Prpsc for development of prion diagnostics including the generation of PrpSc-specific antibody. PMID:22528082

  18. PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells.

    PubMed

    Arkhipenko, Alexander; Syan, Sylvie; Victoria, Guiliana Soraya; Lebreton, Stéphanie; Zurzolo, Chiara

    2016-01-01

    The Prion Protein (PrP) is an ubiquitously expressed glycosylated membrane protein attached to the external leaflet of the plasma membrane via a glycosylphosphatidylinositol anchor (GPI). While the misfolded PrPSc scrapie isoform is the infectious agent of prion disease, the cellular isoform (PrPC) is an enigmatic protein with unclear function. Of interest, PrP localization in polarized MDCK cells is controversial and its mechanism of trafficking is not clear. Here we investigated PrP traffic in MDCK cells polarized on filters and in three-dimensional MDCK cysts, a more physiological model of polarized epithelia. We found that, unlike other GPI-anchored proteins (GPI-APs), PrP undergoes basolateral-to-apical transcytosis in fully polarized MDCK cells. Following this event full-length PrP and its cleavage fragments are segregated in different domains of the plasma membrane in polarized cells in both 2D and 3D cultures. PMID:27389581

  19. PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells

    PubMed Central

    Arkhipenko, Alexander; Syan, Sylvie; Victoria, Guiliana Soraya

    2016-01-01

    The Prion Protein (PrP) is an ubiquitously expressed glycosylated membrane protein attached to the external leaflet of the plasma membrane via a glycosylphosphatidylinositol anchor (GPI). While the misfolded PrPSc scrapie isoform is the infectious agent of prion disease, the cellular isoform (PrPC) is an enigmatic protein with unclear function. Of interest, PrP localization in polarized MDCK cells is controversial and its mechanism of trafficking is not clear. Here we investigated PrP traffic in MDCK cells polarized on filters and in three-dimensional MDCK cysts, a more physiological model of polarized epithelia. We found that, unlike other GPI-anchored proteins (GPI-APs), PrP undergoes basolateral-to-apical transcytosis in fully polarized MDCK cells. Following this event full-length PrP and its cleavage fragments are segregated in different domains of the plasma membrane in polarized cells in both 2D and 3D cultures. PMID:27389581

  20. The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer

    PubMed Central

    Pocanschi, Cosmin L.; Ehsani, Sepehr; Mehrabian, Mohadeseh; Wille, Holger; Reginold, William; Trimble, William S.; Wang, Hansen; Yee, Adelinda; Arrowsmith, Cheryl H.; Bozóky, Zoltán; Kay, Lewis E.; Forman-Kay, Julie D.; Rini, James M.; Schmitt-Ulms, Gerold

    2013-01-01

    The cellular prion protein (PrPC) was recently observed to co-purify with members of the LIV-1 subfamily of ZIP zinc transporters (LZTs), precipitating the surprising discovery that the prion gene family descended from an ancestral LZT gene. Here, we compared the subcellular distribution and biophysical characteristics of LZTs and their PrP-like ectodomains. When expressed in neuroblastoma cells, the ZIP5 member of the LZT subfamily was observed to be largely directed to the same subcellular locations as PrPC and both proteins were seen to be endocytosed through vesicles decorated with the Rab5 marker protein. When recombinantly expressed, the PrP-like domain of ZIP5 could be obtained with yields and levels of purity sufficient for structural analyses but it tended to aggregate, thereby precluding attempts to study its structure. These obstacles were overcome by moving to a mammalian cell expression system. The subsequent biophysical characterization of a homogeneous preparation of the ZIP5 PrP-like ectodomain shows that this protein acquires a dimeric, largely globular fold with an α-helical content similar to that of mammalian PrPC. The use of a mammalian cell expression system also allowed for the expression and purification of stable preparations of Takifugu rubripes PrP-1, thereby overcoming a key hindrance to high-resolution work on a fish PrPC. PMID:24039764

  1. PrP0\\0 mice show behavioral abnormalities that suggest PrPC has a role in maintaining the cytoskeleton.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background/Introduction. PrPC is highly conserved among mammals, but its natural function is unclear. Prnp ablated mice (PrP0/0) appear to develop normally and are able to reproduce. These observations seem to indicate that the gene is not essential for viability, in spite of it being highly conse...

  2. Registration of PR0806-80 and PR0806-81 white bean germplasm lines with resistance to BGYMV, BCMV, BCMNV and rust

    Technology Transfer Automated Retrieval System (TEKTRAN)

    PR0806-80 (Reg. No. GP-___, PI ______) and PR0806-81 (Reg. No. GP-___, PI ______) are multiple disease resistant dry bean (Phaseolus vulgaris L.) germplasm lines, adapted to the humid tropics, that were developed and released cooperatively by the University of Puerto Rico Agricultural Experiment Sta...

  3. Acceptability of Pre-Exposure Prophylaxis (PrEP) as an HIV prevention strategy: Barriers and facilitators to PrEP uptake among at-risk Peruvian populations

    PubMed Central

    Galea, Jerome T.; Kinsler, Janni J.; Salazar, Ximena; Lee, Sung-Jae; Giron, Maziel; Sayles, Jennifer N.; Cáceres, Carlos; Cunningham, William E.

    2010-01-01

    This study examined Pre-Exposure Prophylaxis (PrEP) acceptability among female sex workers, male-to-female transgendered persons, and men who have sex with men in Lima, Peru. Focus groups explored social issues associated with PrEP acceptability and conjoint analysis assessed preferences among eight hypothetical PrEP scenarios with varying attribute profiles and their relative impact on acceptability. Conjoint analysis revealed that PrEP acceptability ranged from 19.8 to 82.5 out of a possible score of 100 across the eight hypothetical PrEP scenarios. Out-of-pocket cost had the greatest impact on PrEP acceptability (25.2, p <0.001), followed by efficacy (21.4, p <0.001) and potential side effects (14.7, p <0.001). Focus group data supported these findings, and also revealed that potential sexual risk disinhibition, stigma and discrimination associated with PrEP use, and mistrust of health care professionals were also concerns. These issues will require careful attention when planning for PrEP roll-out if proven efficacious in ongoing clinical trials. PMID:21571973

  4. HIV Type 1 Molecular Epidemiology in pol and gp41 Genes Among Naive Patients from Mato Grosso do Sul State, Central Western Brazil

    PubMed Central

    da Silveira, Alexsander Augusto; Cardoso, Ludimila Paula Vaz; Francisco, Roberta Barbosa Lopes

    2012-01-01

    Abstract Antiretroviral naive patients (n=49) were recruited in central western Brazil (Campo Grande City/Mato Grosso do Sul State, located across the Bolivia and Paraguay borders). HIV-1 protease (PR), reverse transcriptase (RT), and env gp41 HR1 fragments were sequenced. Genetic diversity was analyzed by REGA/phylogenetic analyses. Intersubtype recombinants were identified by SimPlot/phylogenetic trees. PR/RT resistance was analyzed by Calibrated Population Resistance/Stanford databases. T-20 resistance in gp41 was assessed by Stanford, Los Alamos, and other sources. Of HIV-1 subtypes 65.3% were BPRBRT, 10.2% were CPRCRT, and 8.2% were F1PRF1RT. Intersubtype recombinants were 16.3%: four B/F1 and four B/C (two were “CRF31_BC-like”). The Pol-RT V75M mutation was detected in two homosexual partners; one patient had the T215S revertant mutation. T-20/gp41 resistance mutations were L44M (n=2) and V38A (n=1). The high percentage of non-B isolates (∼35%) highlights the importance of molecular surveillance studies in settings distant from the origin of the epidemic. Our data help elaborate the molecular epidemiological map of HIV-1 in Brazil. PMID:21790471

  5. PR-EDB: Power Reactor Embrittlement Database - Version 3

    SciTech Connect

    Wang, Jy-An John; Subramani, Ranjit

    2008-03-01

    The aging and degradation of light-water reactor pressure vessels is of particular concern because of their relevance to plant integrity and the magnitude of the expected irradiation embrittlement. The radiation embrittlement of reactor pressure vessel materials depends on many factors, such as neutron fluence, flux, and energy spectrum, irradiation temperature, and preirradiation material history and chemical compositions. These factors must be considered to reliably predict pressure vessel embrittlement and to ensure the safe operation of the reactor. Large amounts of data from surveillance capsules are needed to develop a generally applicable damage prediction model that can be used for industry standards and regulatory guides. Furthermore, the investigations of regulatory issues such as vessel integrity over plant life, vessel failure, and sufficiency of current codes, Standard Review Plans (SRPs), and Guides for license renewal can be greatly expedited by the use of a well-designed computerized database. The Power Reactor Embrittlement Database (PR-EDB) is such a comprehensive collection of data for U.S. designed commercial nuclear reactors. The current version of the PR-EDB lists the test results of 104 heat-affected-zone (HAZ) materials, 115 weld materials, and 141 base materials, including 103 plates, 35 forgings, and 3 correlation monitor materials that were irradiated in 321 capsules from 106 commercial power reactors. The data files are given in dBASE format and can be accessed with any personal computer using the Windows operating system. "User-friendly" utility programs have been written to investigate radiation embrittlement using this database. Utility programs allow the user to retrieve, select and manipulate specific data, display data to the screen or printer, and fit and plot Charpy impact data. The PR-EDB Version 3.0 upgrades Version 2.0. The package was developed based on the Microsoft .NET framework technology and uses Microsoft Access for

  6. Popular Education in Brazil. A Report on the LASG/WEA 1985 Study Visit to Brazil.

    ERIC Educational Resources Information Center

    Workers Educational Association, Sunderland (England). Northern District.

    The 11 "themes" in this report describe the three-week study visit of 11 adult education workers from Northern England to Brazil. The report describes contacts with Brazilian colleagues in workers' and popular education and in related support services and trade and popular organizations they serve. "Organization of the Visit" (Victor Cadaxa)…

  7. Basic Education in Brazil: What's Wrong and How to Fix It. Thinking Brazil. No. 25

    ERIC Educational Resources Information Center

    Woodrow Wilson International Center for Scholars, 2007

    2007-01-01

    While Brazil has successfully achieved universal access to basic education, the quality of education remains stubbornly low. A recent study by the Instituto de Pesquisa Economica Aplicada (IPEA) shows that the average 25 years old Brazilian has completed only nine years of education. Almost eleven percent of the population is illiterate and a…

  8. User Education and Marketing of Information Services in Brazil.

    ERIC Educational Resources Information Center

    Figueiredo, Nice

    Arguing that marketing appears to be a solid means for creating users' needs for information as well as for attracting potential users to the library, this paper reviews the current literature in Brazil on marketing information services and on user education. It also discusses the current status of library education in Brazil. An analysis of the…

  9. Distinct Zika Virus Lineage in Salvador, Bahia, Brazil

    PubMed Central

    Naccache, Samia N.; Thézé, Julien; Sardi, Silvia I.; Somasekar, Sneha; Greninger, Alexander L.; Bandeira, Antonio C.; Campos, Gubio S.; Tauro, Laura B.; Faria, Nuno R.; Pybus, Oliver G.

    2016-01-01

    Sequencing of isolates from patients in Bahia, Brazil, where most Zika virus cases in Brazil have been reported, resulted in 11 whole and partial Zika virus genomes. Phylogenetic analyses revealed a well-supported Bahia-specific Zika virus lineage, which indicates sustained Zika virus circulation in Salvador, Bahia’s capital city, since mid-2014. PMID:27448188

  10. Distinct Zika Virus Lineage in Salvador, Bahia, Brazil.

    PubMed

    Naccache, Samia N; Thézé, Julien; Sardi, Silvia I; Somasekar, Sneha; Greninger, Alexander L; Bandeira, Antonio C; Campos, Gubio S; Tauro, Laura B; Faria, Nuno R; Pybus, Oliver G; Chiu, Charles Y

    2016-10-01

    Sequencing of isolates from patients in Bahia, Brazil, where most Zika virus cases in Brazil have been reported, resulted in 11 whole and partial Zika virus genomes. Phylogenetic analyses revealed a well-supported Bahia-specific Zika virus lineage, which indicates sustained Zika virus circulation in Salvador, Bahia's capital city, since mid-2014.

  11. Brazil: Finance of Primary Education. A World Bank Country Study.

    ERIC Educational Resources Information Center

    Winkler, D.; And Others

    Compiled by the World Bank, this study of educational finance in Brazil identifies principal problems, possible solutions, and recommendations for policy changes. The study indicates that Brazil has not given high priority to educational investment, and identifies the problems as: (1) a lack of financial policy analysis and planning; (2) too…

  12. Climate Change Education for Sustainability in Brazil: A Status Report

    ERIC Educational Resources Information Center

    Trajber, Rachel; Mochizuki, Yoko

    2015-01-01

    This article maps and explains Brazil's policies, strategies, plans and initiatives related to Climate Change Education (CCE), in the overall context of Environmental Education (EE) and Education for Sustainable Development (ESD). The case of Brazil offers useful insights on how to enhance climate response through education because of its unique…

  13. First report of Enterocytozoon bieneusi in pigs in Brazil

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Although Brazil is the world’s fourth largest producer and exporter of pork, there is no information on E. bieneusi in pigs. This study was undertaken to determine the presence of E. bieneusi in pigs in the State of Rio de Janeiro, Brazil. Fecal samples were collected from 91 pigs (1- to 12-mo-old) ...

  14. Focus on Brazil: A Case Study of Development.

    ERIC Educational Resources Information Center

    Truhan, Deborah L.

    The teaching unit is designed to help senior high school and college students learn about national development in Brazil. In this case study, development is defined as advances in social well-being and economic growth. Brazil was chosen as an example of a developing nation which depends upon foreign markets, technology, and capital. The country…

  15. Publishing, Books and Library Resources: Brazil and Argentina.

    ERIC Educational Resources Information Center

    National Book Committee, Inc., New York, NY.

    This survey synthesizes and analyzes the book resources and book requirements of Brazil, with particular reference to the educational scene, in terms of local production and distribution resources and capabilities. Information on the geography, political establishment, economy, and educational system of Brazil is presented in the introductory…

  16. Distance Education and Corporate Training in Brazil: Regulations and Interrelationships

    ERIC Educational Resources Information Center

    Porto, Stella C. S.; Berge, Zane L.

    2008-01-01

    Distance education in Brazil has evolved more slowly than distance education offerings in other developing countries. This is because all aspects of Brazil's publicly-funded educational system are excessively regulated, highly bureaucratic, and tightly centralized. Such highly centralized bureaucracy and strict control has resulted in tremendous…

  17. An Overview of Engineering Courses in Brazil: Actual Challenges

    ERIC Educational Resources Information Center

    Canen, Alberto G.; Tammela, Iara; Camatta, Diogo Cevolani

    2016-01-01

    Brazil is one of the largest countries in the world as well one of the greatest economies among developing countries. To be competitive, Brazil needs to be able to develop technology, research and knowledge. In this sense, we argue that economic growth is directly related to technological development, which is linked to the investments in…

  18. Rural Sociology in Brazil: Institutional Growth (1965-1977).

    ERIC Educational Resources Information Center

    Hansen, David O.; And Others

    Growth and present status of graduate programs, major research interests, and potential for US-Brazilian collaboration indicate the present state of rural sociology in Brazil. In contrast to US rural sociology's identity crisis of the past decade, the field in Brazil has blossomed. Graduate programs are underway at universities of Rio Grande do…

  19. Species H rotavirus detected in piglets with diarrhea, Brazil, 2012.

    PubMed

    Molinari, Bruna L D; Lorenzetti, Elis; Otonel, Rodrigo A A; Alfieri, Alice F; Alfieri, Amauri A

    2014-06-01

    We determined nucleotide and deduced amino acid sequences of the rotavirus gene encoding viral protein 6 from 3 fecal samples collected from piglets with diarrhea in Brazil, 2012. The analyses showed that the porcine rotavirus strains in Brazil are closely related to the novel species H rotavirus. PMID:24855935

  20. Reframing Agrarian Citizenship: Land, Life and Power in Brazil

    ERIC Educational Resources Information Center

    Wittman, Hannah

    2009-01-01

    This paper investigates the changing relationship between land, citizenship, and power in Brazil, where land-related policies have historically served to situate political and economic rights in the hands of an elite land-owning minority. In response, contemporary grassroots movements in Brazil, including the Landless Rural Workers Movement…

  1. A conspectus on the Canacidae (Diptera) of Brazil

    PubMed Central

    Mathis, Wayne N.; Marinoni, Luciane

    2012-01-01

    Abstract Species of Canacidae sensu lato of Brazil are reviewed, including the subfamilies Canacinae and Tethininae. Included are seven species in five genera with two species, Nocticanace austra and Nocticanace packhamorum, from southern Brazil being newly described. To facilitate identification, we have included keys and diagnose to taxa at all levels. PMID:22303126

  2. [Social support and physical activity in adolescents from public schools: the importance of family and friends].

    PubMed

    Prado, Crisley Vanessa; Lima, Alex Vieira; Fermino, Rogério César; Añez, Ciro Romelio Rodriguez; Reis, Rodrigo Siqueira

    2014-04-01

    The aim of this study was to verify the association between different types and sources of social support and physical activity among adolescents from Curitiba, Paraná State, Brazil. A school-based survey was conducted with a representative sample of adolescents from public schools (n = 1,469). Multiple regression models were used to test the association between weekly frequency and sources of social support from family and friends and weekly frequency of physical activity. Among boys, frequent company of family (PR: 2.88; 95%CI: 2.00-4.13) and friends (PR: 5.46; 95%CI: 2.33-12.78) and positive reinforcement from friends (PR: 1.81; 95%CI: 1.18-2.77) were positively associated with physical activity. Sporadic invitation by the family was negatively associated with physical activity (PR: 0.66; 95%CI: 0.46-1.14). For girls, frequent company of family (PR: 3.39; 95%CI: 1.49-7.69) and friends (PR: 4.06; 95%CI: 2.22-7.45) increased the likelihood of physical activity. Company of friends was the most important type of social support for physical activity among these adolescents.

  3. [Social support and physical activity in adolescents from public schools: the importance of family and friends].

    PubMed

    Prado, Crisley Vanessa; Lima, Alex Vieira; Fermino, Rogério César; Añez, Ciro Romelio Rodriguez; Reis, Rodrigo Siqueira

    2014-04-01

    The aim of this study was to verify the association between different types and sources of social support and physical activity among adolescents from Curitiba, Paraná State, Brazil. A school-based survey was conducted with a representative sample of adolescents from public schools (n = 1,469). Multiple regression models were used to test the association between weekly frequency and sources of social support from family and friends and weekly frequency of physical activity. Among boys, frequent company of family (PR: 2.88; 95%CI: 2.00-4.13) and friends (PR: 5.46; 95%CI: 2.33-12.78) and positive reinforcement from friends (PR: 1.81; 95%CI: 1.18-2.77) were positively associated with physical activity. Sporadic invitation by the family was negatively associated with physical activity (PR: 0.66; 95%CI: 0.46-1.14). For girls, frequent company of family (PR: 3.39; 95%CI: 1.49-7.69) and friends (PR: 4.06; 95%CI: 2.22-7.45) increased the likelihood of physical activity. Company of friends was the most important type of social support for physical activity among these adolescents. PMID:24896057

  4. Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion.

    PubMed

    Honda, Hiroyuki; Sasaki, Kensuke; Minaki, Haruhiko; Masui, Kenta; Suzuki, Satoshi O; Doh-Ura, Katsumi; Iwaki, Toru

    2012-04-01

    Intraventricular infusion of pentosan polysulfate (PPS) as a treatment for various human prion diseases has been applied in Japan. To evaluate the influence of PPS treatment we performed pathological examination and biochemical analyses of PrP molecules in autopsied brains treated with PPS (one case of sporadic Creutzfeldt-Jakob disease (sCJD, case 1), two cases of dura mater graft-associated CJD (dCJD, cases 2 and 4), and one case of Gerstmann-Sträussler-Scheinker disease (GSS, case 3). Six cases of sCJD without PPS treatment were examined for comparison. Protease-resistant PrP (PrP(res) ) in the frontal lobe was evaluated by Western blotting after proteinase K digestion. Further, the degree of polymerization of PrP molecules was examined by the size-exclusion gel chromatography assay. PPS infusions were started 3-10 months after disease onset, but the treatment did not achieve any clinical improvements. Postmortem examinations of the treated cases revealed symmetrical brain lesions, including neuronal loss, spongiform change and gliosis. Noteworthy was GFAP in the cortical astrocytes reduced in all treated cases despite astrogliosis. Immunohistochemistry for PrP revealed abnormal synaptic deposits in all treated cases and further plaque-type PrP deposition in case 3 of GSS and case 4 of dCJD. Western blotting showed relatively low ratios of PrP(res) in case 2 of dCJD and case 3 of GSS, while in the treated sCJD (case 1), the ratio of PrP(res) was comparable with untreated cases. The indices of oligomeric PrP were reduced in one sCJD (case 1) and one dCJD (case 2). Although intraventricular PPS infusion might modify the accumulation of PrP oligomers in the brains of patients with prion diseases, the therapeutic effects are still uncertain.

  5. Rectal temperatures, respiratory rates, production, and reproduction performances of crossbred Girolando cows under heat stress in northeastern Brazil

    NASA Astrophysics Data System (ADS)

    da Costa, Antônio Nélson Lima; Feitosa, José Valmir; Montezuma, Péricles Afonso; de Souza, Priscila Teixeira; de Araújo, Airton Alencar

    2015-11-01

    This study compared the two breed groups of Girolando (½ Holstein ½ Gyr vs. ¾ Holstein ¼ Gyr) through analysis of the percentages (stressed or non-stressed cows) of rectal temperature (RT), respiratory rate (RR) and pregnancy rate (PR), and means of production and reproduction parameters to determine the group best suited to rearing in semiarid tropical climate. The experiment was conducted at the farm, in the municipality of Umirim, State of Ceará, Brazil. Two hundred and forty cows were used in a 2 × 2 factorial study; 120 of each group were kept under an intensive system during wet and dry seasons. The environmental parameters obtained were relative humidity (RH), air temperature (AT), and the temperature and humidity index (THI). Pregnancy diagnosis (PD) was determined by ultrasonography 30 days after artificial insemination (AI). The milk production of each cow was recorded with automated milkings in the farm. The variables were expressed as mean and standard error, evaluated by ANOVA at 5 % probability using the GLM procedure of SAS. Chi-square test at 5 % probability was applied to data of RT, RR, pregnancy rate (PR), and the number of AIs to obtain pregnancy. The majority of ½ Holstein cows showed mean values of RT and RR within the normal range in both periods and shifts. Most animals of the ¾ Holstein group exhibited the RR means above normal during the afternoon in the rainy and dry periods and RT means above normal during the afternoon in the dry period. After analyses, ½ Holstein crossbred cows are more capable of thermoregulating than ¾ Holstein cows under conditions of thermal stress, and the dry period was more impacting for bovine physiology with significant changes in physiological parameters, even for the first breed group. Knowledge of breed groups adapted to climatic conditions of northeastern Brazil can directly assist cattle farmers in selecting animals best adapted for forming herds.

  6. Psychological violence against pregnant women in a prenatal care cohort: rates and associated factors in São Luís, Brazil

    PubMed Central

    2014-01-01

    Background Violence against pregnant women has been associated with gestational and perinatal disorders. Psychological violence is the type least investigated and its associated factors have been little studied. The present study was conducted in order to estimate prevalence rates and analyze the factors associated with exclusive and recurrent psychological violence in the municipality of São Luís, Brazil. Methods Data regarding 982 pregnant women, aged from 14 to 45 years, interviewed in 2010 and 2011 in a prenatal cohort were used. A self-applied questionnaire was used to screen for violence. Pregnant women submitted to physical and sexual violence were excluded from the analysis of factors associated with exclusive psychological violence. Prevalence ratios and 95% confidence intervals were estimated by a Poisson regression model with a hierarchical approach at three levels. At level 1 of the theoretical-conceptual model, we analyzed demographic and socioeconomic characteristics and variables that express gender inequalities; at level 2, we analyzed social support received by the women, and at level 3, the life experiences of the pregnant women. Results Prevalence rate of exclusive psychological violence was 41.6% and of recurrent violence was 32.6%. Exclusive psychological violence was associated with pregnant women’s age of 14 to 18 years (PR: 1.32 95% CI: 1.04 – 1.70), pregnant women’s schooling superior to that of her intimate partner (PR: 1.54 95% CI: 1.09 – 2.16), inadequate social affective support/positive social interaction (PR: 1.34 95% CI: 1.11 – 1.62), use of illicit drugs by the pregnant women (PR: 1.80 95% CI: 1.16 – 2.81) and having had six or more intimate partners in life (PR: 1.52 95% CI: 1.18 – 1.96). Recurrent exclusive psychological violence was associated with inadequate social affective support/positive social interaction (PR: 1.47 95% CI: 1.15 – 1.87), use of illicit drugs by the pregnant women (PR: 2,28 95% CI: 1

  7. Substitution of Y for Pr in PrMn2Ge2—The magnetism of Pr0.8Y0.2Mn2Ge2

    NASA Astrophysics Data System (ADS)

    Wang, J. L.; Campbell, S. J.; Hofmann, M.; Kennedy, S. J.; Avdeev, M.; Md Din, M. F.; Zeng, R.; Cheng, Z. X.; Dou, S. X.

    2013-05-01

    Pr0.8Y0.2Mn2Ge2 is found to exhibit four magnetic transitions on decreasing the temperature from the paramagnetic region: (i) paramagnetism to intralayer antiferromagnetism (AFl) at TNintra; (ii) AFl to canted ferromagnetism (Fmc) at TCinter; (iii) Fmc to conical magnetic ordering of the Mn sublattice (Fmi) at Tcc; and (iv) Fmi(Mn) to Fmi(Mn) + F(Pr) at TCPr. These changes in magnetic structure are discussed in terms of changes in the Mn-Mn separation distances caused by the unit cell contraction and by electronic effects due to replacement of 20% of Pr with Y.

  8. Using protein misfolding cyclic amplification generates a highly neurotoxic PrP dimer causing neurodegeneration.

    PubMed

    Yang, XiuJin; Yang, LiFeng; Zhou, XiangMei; Khan, Sher Hayat; Wang, HuiNuan; Yin, XiaoMin; Yuan, Zhen; Song, ZhiQi; Wu, WenYu; Zhao, DeMing

    2013-11-01

    Under the "protein-only" hypothesis, prion-based diseases are proposed to result from an infectious agent that is an abnormal isoform of the prion protein in the scrapie form, PrP(Sc). However, since PrP(Sc) is highly insoluble and easily aggregates in vivo, this view appears to be overly simplistic, implying that the presence of PrP(Sc) may indirectly cause neurodegeneration through its intermediate soluble form. We generated a neurotoxic PrP dimer with partial pathogenic characteristics of PrP(Sc) by protein misfolding cyclic amplification in the presence of 1-palmitoyl-2-oleoylphosphatidylglycerol consisting of recombinant hamster PrP (23-231). After intracerebral injection of the PrP dimer, wild-type hamsters developed signs of neurodegeneration. Clinical symptoms, necropsy findings, and histopathological changes were very similar to those of transmissible spongiform encephalopathies. Additional investigation showed that the toxicity is primarily related to cellular apoptosis. All results suggested that we generated a new neurotoxic form of PrP, PrP dimer, which can cause neurodegeneration. Thus, our study introduces a useful model for investigating PrP-linked neurodegenerative mechanisms.

  9. Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies.

    PubMed

    Donofrio, Gaetano; Heppner, Frank L; Polymenidou, Magdalini; Musahl, Christine; Aguzzi, Adriano

    2005-07-01

    Prion diseases are characterized by the deposition of PrP(Sc), an abnormal form of the cellular prion protein PrP(C). A growing body of evidence suggests that antibodies to PrP(C) can antagonize deposition of PrP(Sc). However, host tolerance hampers the induction of immune responses to PrP(C), and cross-linking of PrP(C) by bivalent anti-PrP antibodies is neurotoxic. In order to obviate these problems, we explored the antiprion potential of recombinant single-chain antibody (scFv) fragments. scFv fragments derived from monoclonal anti-PrP antibody 6H4, flagged with c-myc and His6 tags, were correctly processed and secreted by mammalian RD-4 rhabdomyosarcoma cells. When cocultured with cells secreting anti-PrP scFv, chronically prion-infected neuroblastoma cells ceased to produce PrP(Sc), even if antibody-producing cells were physically separated from target cells in transwell cultures. Expression of scFv with irrelevant specificity, or of similarly tagged molecules, was not curative. Therefore, eukaryotically expressed scFv exerts a paracrine antiprion activity. The effector functions encoded by immunoglobulin constant domains are unnecessary for this effect. Because of their small size and their monovalent binding, scFv fragments may represent candidates for gene transfer-based immunotherapy of prion diseases.

  10. PrP106-126 peptide disrupts lipid membranes: Influence of C-terminal amidation

    SciTech Connect

    Zheng Wenfu; Wang Lijun; Hong Yuankai; Sha Yinlin

    2009-02-06

    PrP106-126 is located within the important domain concerning membrane related conformational conversion of human Prion protein (from cellular isoform PrP{sup C} to scrapie isoform PrP{sup Sc}). Recent advances reveal that the pathological and physicochemical properties of PrP106-126 peptide are very sensitive to its N-terminal amidation, however, the detailed mechanism remains unclear. In this work, we studied the interactions of the PrP106-126 isoforms (PrP106-126{sub CONH2} and PrP106-126{sub COOH}) with the neutral lipid bilayers by atomic force microscopy, surface plasmon resonance and fluorescence spectroscopy. The membrane structures were disturbed by the two isoforms in a similarly stepwise process. The distinct morphological changes of the membrane were characterized by formation of semi-penetrated defects and sigmoidal growth of flat high-rise domains on the supported lipid bilayers. However, PrP106-126{sub COOH} displayed a higher peptide-lipid binding affinity than PrP106-126{sub CONH2} ({approx}2.9 times) and facilitated the peptide-lipid interactions by shortening the lag time. These results indicate that the C-terminal amidation may influence the pathological actions of PrP106-126 by lowering the interaction potentials with lipid membranes.

  11. Analysis of cleavage site mutations between the NC and PR Gag domains of Rous sarcoma virus.

    PubMed Central

    Schatz, G; Pichova, I; Vogt, V M

    1997-01-01

    In retroviruses, the viral protease (PR) is released as a mature protein by cleavage of Gag, Gag-Pro, or Gag-Pro-Pol precursor polypeptides. In avian sarcoma and leukemia viruses (ASLV), PR forms the C-terminal domain of Gag. Based on the properties of a mutation (cs22) in the cleavage site between the upstream NC domain and the PR domain, the proteolytic liberation of PR previously was inferred to be essential for processing of Gag and Pol proteins. To study this process in more detail, we have analyzed the effects that several mutations at the NC-PR cleavage site have on proteolytic processing in virus-like particles expressed in COS and quail cells. Mutant Gag proteins carrying the same mutations also were synthesized in vitro and tested for processing with purified PR. In both types of studies, N-terminal sequencing of the liberated PR domain was carried out to exactly identify the site of cleavage. Finally, synthetic peptides corresponding to the mutant proteins were assessed for the ability to act as substrates for PR. The results were all consistent and led to the following conclusions. (i) In vivo, if normal processing between NC and PR is prevented by mutations, limited cleavage occurs at a previously unrecognized alternative site three amino acids downstream, i.e., in PR. This N-terminally truncated PR is inactive as an enzyme, as inferred from the global processing defect in cs22 and a similar mutant. (ii) In Gag proteins translated in vitro, purified PR cleaves this alternative site as rapidly as it does the wild-type site. (iii) Contrary to previously accepted rules describing retroviral cleavage sites, an isoleucine residue placed at the P1 position of the NC-PR cleavage site does not hinder normal processing. (iv) A proline residue placed at the P2 position in this cleavage site blocks normal processing. PMID:8985369

  12. Fishers' knowledge and seahorse conservation in Brazil

    PubMed Central

    Rosa, Ierecê ML; Alves, Rômulo RN; Bonifácio, Kallyne M; Mourão, José S; Osório, Frederico M; Oliveira, Tacyana PR; Nottingham, Mara C

    2005-01-01

    From a conservationist perspective, seahorses are threatened fishes. Concomitantly, from a socioeconomic perspective, they represent a source of income to many fishing communities in developing countries. An integration between these two views requires, among other things, the recognition that seahorse fishers have knowledge and abilities that can assist the implementation of conservation strategies and of management plans for seahorses and their habitats. This paper documents the knowledge held by Brazilian fishers on the biology and ecology of the longsnout seahorse Hippocampus reidi. Its aims were to explore collaborative approaches to seahorse conservation and management in Brazil; to assess fishers' perception of seahorse biology and ecology, in the context evaluating potential management options; to increase fishers' involvement with seahorse conservation in Brazil. Data were obtained through questionnaires and interviews made during field surveys conducted in fishing villages located in the States of Piauí, Ceará, Paraíba, Maranhão, Pernambuco and Pará. We consider the following aspects as positive for the conservation of seahorses and their habitats in Brazil: fishers were willing to dialogue with researchers; although captures and/or trade of brooding seahorses occurred, most interviewees recognized the importance of reproduction to the maintenance of seahorses in the wild (and therefore of their source of income), and expressed concern over population declines; fishers associated the presence of a ventral pouch with reproduction in seahorses (regardless of them knowing which sex bears the pouch), and this may facilitate the construction of collaborative management options designed to eliminate captures of brooding specimens; fishers recognized microhabitats of importance to the maintenance of seahorse wild populations; fishers who kept seahorses in captivity tended to recognize the condtions as poor, and as being a cause of seahorse mortality. PMID

  13. [The cases of China and Brazil].

    PubMed

    Mundigo, A

    1987-01-01

    Demographic developments and family planning in China and Brazil are described and compared. Postrevolutionary China was characterized by initial rapid economic expansion, followed later by recurrent agricultural crises. Abortion and sterilization were strictly forbidden. The mid-twenties was legal minimum age for marrying, thus increasing the work force. In the early 1960s, population control measures were introduced, legalizing sterilization and abortion, a trend reversed, in 1966, by the cultural revolution, which resulted in a baby boom and an enormous proportion of young women, today, in their reproductive ages. Various stages of increased government involvement finally resulted in a 1 family, 1 child policy adopted in 1978, coercing families and individuals to sign a certificate, severely limiting earning potentials and privileges, if having more than 1 child. By the year 2050, if current policies are being enforced, the population is projected to be 917 million. Brazil traditionally has had an intellectual pro-natality movement, due to its vast internal space, low population density and high economic productive capacity. By 1970, however, the economic miracle had passed. Child mortality and health problems became rampant. Democratizing access to contraceptive means and services, and the economic for migration to large empty spaces of the country were emphasized. The state assumed responsibility for providing contraceptive means instead of leaving it in the hands of private agencies. Brazil refuses to recognize simplistic rhetoric blaming population increases for all ills in the developing countries and espouses the position that planning for children, the more positive term for family planning, is a fundamental right of all human beings and should stem from free and informed choice by couples and individuals.

  14. Use of GIS for Earthquakes in Brazil

    NASA Astrophysics Data System (ADS)

    Franca, G. S.; Algarte, K. T.; Assumpcao, M.; Barbosa, J. R.; Roig, H. L.; Pascual, M. F.; Vasconcelos, A. E.; Ferreira, J. M.; Ribotta, L. C.; do Nascimento, A. F.; Pavao, C. G.

    2011-12-01

    We present geoprocessing techniques to monitor and analyse earthquakes in Brazil. We constructed a georeferenced database called SIGSIBRA using PostgreSQL + PostGIS softwares, and fed by information from the SISBRA earthquake catalog, IBGE geographical data and CPRM geological data. The SISBRA catalog was built from the book "Sismicidade Brasileira" (Berrocal et al, 1984), updated with the Brazilian seismic bulletins from the Brazilian Geophysical Journal up to 1995, and especially with the data from seismographic monitoring activities of the University of Brasília-SIS/UnB, the Federal University of Rio Grande do Norte-UFRN, the University of Sao Paulo-USP and the Institute for Technological Research (IPT). Earthquakes occur in Brazil with moderate to low magnitudes. Besides natural earthquakes, seismic activity triggered by water dams must also be monitored. With the growing number and size of Brazilian dams (because of the many rivers, favorable topography and "clean" energy) concern with reservoir triggered seismicity is expected to increase. Approval for the construction of a hydropower plant requires seismic hazard assesmment prepared by an interdisciplinary team, with a large contribution of geoprocessing specialists. Therefore, it is important to study the characteristics of this seismicity, so that these professionals can avoid or mitigate potential environmental and social harm to communities on the margins of large dams. Thus the SIGSIBRA system can generate spatial analysis of its events, such as intensity estimation of "Kernel" points distribution; spatial statistics; spatial autocorrelation (Morans I) and correlations with geological structures, making it possible to characterize important aspects of the Brazilian seismicity. Finally, we show the statistical analysis of the database through the program ZMAP and estimate the intraplate seismogenic zones in Brazil.

  15. Fishers' knowledge and seahorse conservation in Brazil.

    PubMed

    Rosa, Ierecê Ml; Alves, Rômulo Rn; Bonifácio, Kallyne M; Mourão, José S; Osório, Frederico M; Oliveira, Tacyana Pr; Nottingham, Mara C

    2005-12-08

    From a conservationist perspective, seahorses are threatened fishes. Concomitantly, from a socioeconomic perspective, they represent a source of income to many fishing communities in developing countries. An integration between these two views requires, among other things, the recognition that seahorse fishers have knowledge and abilities that can assist the implementation of conservation strategies and of management plans for seahorses and their habitats. This paper documents the knowledge held by Brazilian fishers on the biology and ecology of the longsnout seahorse Hippocampus reidi. Its aims were to explore collaborative approaches to seahorse conservation and management in Brazil; to assess fishers' perception of seahorse biology and ecology, in the context evaluating potential management options; to increase fishers' involvement with seahorse conservation in Brazil. Data were obtained through questionnaires and interviews made during field surveys conducted in fishing villages located in the States of Piauí, Ceará, Paraíba, Maranhão, Pernambuco and Pará. We consider the following aspects as positive for the conservation of seahorses and their habitats in Brazil: fishers were willing to dialogue with researchers; although captures and/or trade of brooding seahorses occurred, most interviewees recognized the importance of reproduction to the maintenance of seahorses in the wild (and therefore of their source of income), and expressed concern over population declines; fishers associated the presence of a ventral pouch with reproduction in seahorses (regardless of them knowing which sex bears the pouch), and this may facilitate the construction of collaborative management options designed to eliminate captures of brooding specimens; fishers recognized microhabitats of importance to the maintenance of seahorse wild populations; fishers who kept seahorses in captivity tended to recognize the condtions as poor, and as being a cause of seahorse mortality.

  16. PrP charge structure encodes interdomain interactions

    PubMed Central

    Martínez, Javier; Sánchez, Rosa; Castellanos, Milagros; Makarava, Natallia; Aguzzi, Adriano; Baskakov, Ilia V.; Gasset, María

    2015-01-01

    Almost all proteins contain charged residues, and their chain distribution is tailored to fulfill essential ionic interactions for folding, binding and catalysis. Among proteins, the hinged two-domain chain of the cellular prion protein (PrPC) exhibits a peculiar charge structure with unclear consequences in its structural malleability. To decipher the charge design role, we generated charge-reverted mutants for each domain and analyzed their effect on conformational and metabolic features. We found that charges contain the information for interdomain interactions. Use of dynamic light scattering and thermal denaturation experiments delineates the compaction of the α-fold by an electrostatic compensation between the polybasic 23–30 region and the α3 electronegative surface. This interaction increases stability and disfavors fibrillation. Independently of this structural effect, the N-terminal electropositive clusters regulate the α-cleavage efficiency. In the fibrillar state, use of circular dichroism, atomic-force and fluorescence microscopies reveal that the N-terminal positive clusters and the α3 electronegative surface dictate the secondary structure, the assembly hierarchy and the growth length of the fibril state. These findings show that the PrP charge structure functions as a code set up to ensure function and reduce pathogenic routes. PMID:26323476

  17. PR-Box Correlations Have No Classical Limit

    NASA Astrophysics Data System (ADS)

    Rohrlich, Daniel

    One of Yakir Aharonov's endlessly captivating physics ideas is the conjecture that two axioms, namely relativistic causality ("no superluminal signalling") and nonlocality, so nearly contradict each other that a unique theory—quantum mechanics—reconciles them. But superquantum (or "PR-box") correlations imply that quantum mechanics is not the most nonlocal theory (in the sense of nonlocal correlations) consistent with relativistic causality. Let us consider supplementing these two axioms with a minimal third axiom: there exists a classical limit in which macroscopic observables commute. That is, just as quantum mechanics has a classical limit, so must any generalization of quantum mechanics. In this classical limit, PR-box correlations violate relativistic causality. Generalized to all stronger-than-quantum bipartite correlations, this result is a derivation of Tsirelson's bound without assuming quantum mechanics. [Editors note: for a video of the talk given by Dr. Rohrlich at the Aharonov-80 conference in 2012 at Chapman University, see http://quantum.chapman.edu/talk-10.

  18. PrP charge structure encodes interdomain interactions.

    PubMed

    Martínez, Javier; Sánchez, Rosa; Castellanos, Milagros; Makarava, Natallia; Aguzzi, Adriano; Baskakov, Ilia V; Gasset, María

    2015-01-01

    Almost all proteins contain charged residues, and their chain distribution is tailored to fulfill essential ionic interactions for folding, binding and catalysis. Among proteins, the hinged two-domain chain of the cellular prion protein (PrP(C)) exhibits a peculiar charge structure with unclear consequences in its structural malleability. To decipher the charge design role, we generated charge-reverted mutants for each domain and analyzed their effect on conformational and metabolic features. We found that charges contain the information for interdomain interactions. Use of dynamic light scattering and thermal denaturation experiments delineates the compaction of the α-fold by an electrostatic compensation between the polybasic 23-30 region and the α3 electronegative surface. This interaction increases stability and disfavors fibrillation. Independently of this structural effect, the N-terminal electropositive clusters regulate the α-cleavage efficiency. In the fibrillar state, use of circular dichroism, atomic-force and fluorescence microscopies reveal that the N-terminal positive clusters and the α3 electronegative surface dictate the secondary structure, the assembly hierarchy and the growth length of the fibril state. These findings show that the PrP charge structure functions as a code set up to ensure function and reduce pathogenic routes. PMID:26323476

  19. Deforestation in Brazil: motivations, journeys and tendencies

    NASA Astrophysics Data System (ADS)

    Leite, J. C.; Ferreira, A. J. D.; Esteves, T. C. J.; Bento, C. P. M.

    2012-04-01

    José Carlos Leite1; António José Dinis Ferreira2; Tanya Cristina de Jesus Esteves2; Célia Patrícia Martins Bento2 1Universidade Federal de Mato Grosso, Brazil; 2IPC - Escola Superior Agrária de Coimbra, Portugal Over the last three decades, deforestation in Brazil occurred systematically in the area known as the "arc of deforestation", an extensive geographical area located in the interface of the Cerrado and the Amazon biomes. This work encompasses the reasons, causes and/or motivations of that recent deforestation, focusing on the Central-West and Northern regions. A number of reasons will be presented, seeking to build an approach able to identify the deepest roots of deforestation of those regions. Our actions over the environment are framed by our cultural matrix that stream from a western philosophic attitude. This way, to understand the framework where the deforestation actions are justified requires a multidisciplinary approach to understand the deforestation of the Cerrado and Amazon biomes, since the motivations for forest destruction in Brazil are complex and not entirely understood within the domains of a single disciplinary area. To search for an isolated cause to understand the recent deforestation can only be plausible if we ignore information on what actually happens. The methodology used in this work is based on a bibliographical revision, analysis of georeferrenced information, participative processes implementation and observation of stakeholder behavior, and field research. It departs from a general vision on deforestation that initially occurred at the littoral region, by the Atlantic Rainforest, right after the arrival of the Europeans, and throughout the centuries penetrates towards the interior, hitting the Cerrado and Amazon biomes. In this last case, we focused on the Vale do Alto Guaporé region, near Bolivia, where the intensity of the deforestation was verified from 1970 to 1990. Ultimately, the final result is a mosaic of reasons

  20. Thirteen new records of ferns from Brazil

    PubMed Central

    Salino, Alexandre

    2015-01-01

    Abstract Thirteen fern species are reported for the first time for Brazil. Among the new records, eight are from Acre state (Cyathea subincisa, Cyclodium trianae, Elaphoglossum stenophyllum, Hypoderris brauniana, Pleopeltis stolzei, Thelypteris arcana, Thelypteris comosa, Thelypteris valdepilosa), two are from Pará state (Polypodium flagellare, Tectaria heracleifolia), one from Minas Gerais state (Alsophila salvinii), one from Ceará state (Campyloneurum costatum) and one from Bahia state (Thelypteris rolandii). Part of the species shows a disjunct occurrence or illustrates floristic relations between Brazilian and Andean Mountains or Central American Mountains. PMID:25829857

  1. [Reproductive rights and racism in Brazil].

    PubMed

    Roland, E

    1995-01-01

    Sterilization in Brazil is discussed in a racial context and contrasted with the experience of the United States, demonstrating the historical differences between these two societies regarding race relations and reproductive rights. The American feminist Angela Davis referred to the control of fertility as genocide, especially as practiced in the first half of the 20th century. In 1906 President Theodore Roosevelt characterized the drop of White fertility caused by rapid urbanization as racial suicide. In 1932 the development of the eugenic movement resulted in inducing 26 states to adopt compulsory sterilization laws for persons considered unfit for reproduction. Margaret Sanger, the protagonist of fertility control, advocated a program of compulsory sterilization for imbeciles, illiterates, criminals, epileptics, the mentally retarded, prostitutes, and drug traffickers. 7686 sterilizations were performed in North Carolina, of which about 5000 were performed on Blacks to prevent the reproduction of mentally retarded persons. It was only in 1974 that guidelines were drawn up to prevent sterilization abuses. Under federal programs 100,000-200,000 persons were sterilized in 1972, and 35% of Puerto Rican women of reproductive age underwent sterilization. In Brazil 44% of the population of 147 million is Black. In 1940 the White population was the majority, but by 1980 a steady increase of the mulatto population had occurred. From 1965 on the White population began to decrease both because of oral contraceptive use and intermarriage. The fertility rate of the mulatto population was 4.1% in 1980 and 2.3% in 1990, less than the 2.4% rate of whites. The total fertility rate (TFR) in Brazil was 3.5 children per woman in 1986, which dropped to 2.5 in 1991. In the northeast, where the majority of the population is Black, the TFR was 3.7 in 1991 vs. 7.5 in 1970. Although in Brazil racial intolerance is not acceptable, there is still inequality of opportunity for Blacks. In

  2. Selective abortion in Brazil: the anencephaly case.

    PubMed

    Diniz, Debora

    2007-08-01

    This paper discusses the Brazilian Supreme Court ruling on the case of anencephaly. In Brazil, abortion is a crime against the life of a fetus, and selective abortion of non-viable fetuses is prohibited. Following a paradigmatic case discussed by the Brazilian Supreme Court in 2004, the use of abortion was authorized in the case of a fetus with anencephaly. The objective of this paper is to analyze the ethical arguments of the case, in particular the strategy of avoiding the moral status of the fetus, the cornerstone thesis of the Catholic Church. PMID:17614991

  3. Hillary Clinton visits Pathfinder projects in Brazil.

    PubMed

    1996-01-01

    In October 1995, US First Lady Hillary Clinton visited a maternity hospital in Salvador, Brazil, in which a family planning (FP)/reproductive health program has been administered by Pathfinder International since 1981 with funding from USAID. During her tour of the facility, Clinton learned about the high degree of unmet need for FP in the region which results from a lack of sufficient resources to meet demand. Clinton, in turn, praised the state of Bahia for its emphasis on FP in low-income areas.

  4. Brazil's remote sensing activities in the Eighties

    NASA Technical Reports Server (NTRS)

    Raupp, M. A.; Pereiradacunha, R.; Novaes, R. A.

    1985-01-01

    Most of the remote sensing activities in Brazil have been conducted by the Institute for Space Research (INPE). This report describes briefly INPE's activities in remote sensing in the last years. INPE has been engaged in research (e.g., radiance studies), development (e.g., CCD-scanners, image processing devices) and applications (e.g., crop survey, land use, mineral resources, etc.) of remote sensing. INPE is also responsible for the operation (data reception and processing) of the LANDSATs and meteorological satellites. Data acquisition activities include the development of CCD-Camera to be deployed on board the space shuttle and the construction of a remote sensing satellite.

  5. Social impacts of Brazil's Tucurui Dam

    SciTech Connect

    Fearnside, P.M.

    1999-11-01

    The Tucurui Dam, which blocked the Tocantins River in 1984 in Brazil's eastern Amazonian state of Para, is a continuing source of controversy. Most benefits of the power go to aluminum smelting companies, where only a tiny amount of employment is generated. Often presented by authorities as a model for hydroelectric development because of the substantial power that it produces, the project's social and environmental impacts are also substantial. Examination of Tucurui reveals a systematic overestimation of benefits and underestimation of impacts as presented by authorities. Tucurui offers many as-yet unlearned lessons for hydroelectric development in Amazonia.

  6. Catholic populism and education in Brazil

    NASA Astrophysics Data System (ADS)

    Paiva, Vanilda

    1995-05-01

    Education in Brazil has been profoundly affected by populism, a movement which extols the virtue of the oppressed classes and opposes the traditional teacherstudent relationship. This movement has antecedents in nineteenth-century Russian writers such as Herzen and Bakunin. The author shows how populist ideas, often merging with Marxism, were adopted by many Brazilian Catholics from the 1950s onwards, under the influence of Vieira Pinto, Paulo Freire and others. In the realm of education this often led to an extreme form of anti-authoritarianism. While not denying certain positive aspects of this movement, the author argues that its position is fundamentally self-contradictory.

  7. Plecoptera from Minas Gerais State, southeastern Brazil.

    PubMed

    Novaes, Marcos Carneiro; Bispo, Pitágoras Da Conceição

    2014-01-01

    Specimens of Plecoptera collected in Minas Gerais State, Brazil were studied. Twelve previously described species were identified, Anacroneuria boraceiensis Froehlich, 2004, A. debilis (Pictet, 1841), A. itatiaiensis Baldin et al., 2013, A. polita (Burmeister, 1839), A. singularis Righi-Cavallaro & Lecci, 2010, A. stanjewetti Froehlich, 2002, A. terere Righi-Cavallaro & Lecci, 2010, A. vanini Froehlich, 2004, Kempnyia neotropica (Jacobson and Bianchi, 1905), K. obtusa Klapálek, 1916, Tupiperla gracilis (Burmeister, 1839) and T. robusta Froehlich, 1998. Additionally, two new species of Anacroneuria are described, A. paprockii n. sp. and A. mineira n. sp., and a list of species from Minas Gerais State is presented. PMID:25284668

  8. Molecular characterization of bromeliads from northeast Brazil.

    PubMed

    Vieira, S D; Rabbani, A R C; Santos, F; Silva-Mann, R; Arrigoni-Blank, M F; Prata, A P N; Resende, L V; Pasqual, M; Blank, A F

    2014-01-01

    Bromeliaceae is an important botany family that includes many species with economic value; demand for members of this family is increasing. However, illegal collection frequently occurs, drastically reducing the species populations; thus, it is necessary to collect and store Bromeliaceae genetic material. In this study, we identified and quantified genetic variability of the Bromeliad family using dominant markers to create the first Germplasm Bank in the northeast region of Brazil. Molecular tools were used to characterize the collected accessions. The combination of 11 inter-simple sequence repeats and 13 random amplified polymorphic DNA markers were used to detect the genetic variability of wild bromeliad accessions. PMID:25501194

  9. Dermatological diseases of compulsory notification in Brazil.

    PubMed

    Penna, Gerson Oliveira; Domingues, Carla M A S; Siqueira Jr, João Bosco; Elkhoury, Ana Nilce S M; Cechinel, Michella P; Grossi, Maria Aparecida de Faria; Gomes, Marcia de Leite S; Sena, Joana M; Pereira, Gerson Fernando Mendes; Lima Júnior, Francisco Edilson F; Segatto, Teresa Cristina Vieira; Melo, Flavia Cardoso de; Rosa, Fabiano Marques; Silva, Marcia Mesquita; Nicolau, Renata Amadei

    2011-01-01

    The development of a Brazilian National Surveillance System in 1975 led to a compulsory reporting of selected infectious diseases aiming to reduce the burden of these events in the country. However, shifts in the epidemiology of these diseases associated with modern life style, demand constant revision of surveillance activities. In this manuscript we present the epidemiology, trends and differential diagnosis of the following compulsory notifiable diseases in Brazil: Aids, dengue fever, hanseniasis, American tegumentary leishmaniasis, measles, rubella and congenital rubella syndrome and syphilis. Additionally, the current challenges for control and prevention of each disease are presented.

  10. Hillary Clinton visits Pathfinder projects in Brazil.

    PubMed

    1996-01-01

    In October 1995, US First Lady Hillary Clinton visited a maternity hospital in Salvador, Brazil, in which a family planning (FP)/reproductive health program has been administered by Pathfinder International since 1981 with funding from USAID. During her tour of the facility, Clinton learned about the high degree of unmet need for FP in the region which results from a lack of sufficient resources to meet demand. Clinton, in turn, praised the state of Bahia for its emphasis on FP in low-income areas. PMID:12179683

  11. Notes for Brazil sampling frame evaluation trip

    NASA Technical Reports Server (NTRS)

    Horvath, R. (Principal Investigator); Hicks, D. R. (Compiler)

    1981-01-01

    Field notes describing a trip conducted in Brazil are presented. This trip was conducted for the purpose of evaluating a sample frame developed using LANDSAT full frame images by the USDA Economic and Statistics Service for the eventual purpose of cropland production estimation with LANDSAT by the Foreign Commodity Production Forecasting Project of the AgRISTARS program. Six areas were analyzed on the basis of land use, crop land in corn and soybean, field size and soil type. The analysis indicated generally successful use of LANDSAT images for purposes of remote large area land use stratification.

  12. 77 FR 51759 - U.S. Medical Mission to Brazil; Sao Paulo, Brazil, May 21-24, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... criteria in making a sale. Best Prospects/Services Brazil's strengthened currency has meant that private... discuss industry developments, opportunities, and sales strategies. Commercial Setting Brazil is the... 30% of the import market, with U.S. sales mainly going through local agents, distributors...

  13. Adult Education and Indigenous Peoples in Brazil. International Survey on Adult Education for Indigenous Peoples. Country Study: Brazil.

    ERIC Educational Resources Information Center

    Lopes da Silva, Aracy

    Adult education for indigenous peoples in Brazil was examined. First, information on government institutions, indigenous organizations, international agencies, and nongovernmental organizations engaged in adult education for Brazil's indigenous peoples was compiled. Next, questionnaires and survey techniques were used to research the policy and…

  14. Na+/K+-ATPase Is Present in Scrapie-Associated Fibrils, Modulates PrP Misfolding In Vitro and Links PrP Function and Dysfunction

    PubMed Central

    Graham, James F.; Kurian, Dominic; Agarwal, Sonya; Toovey, Lorna; Hunt, Lawrence; Kirby, Louise; Pinheiro, Teresa J. T.; Banner, Steven J.; Gill, Andrew C.

    2011-01-01

    Transmissible spongiform encephalopathies are characterised by widespread deposition of fibrillar and/or plaque-like forms of the prion protein. These aggregated forms are produced by misfolding of the normal prion protein, PrPC, to the disease-associated form, PrPSc, through mechanisms that remain elusive but which require either direct or indirect interaction between PrPC and PrPSc isoforms. A wealth of evidence implicates other non-PrP molecules as active participants in the misfolding process, to catalyse and direct the conformational conversion of PrPC or to provide a scaffold ensuring correct alignment of PrPC and PrPSc during conversion. Such molecules may be specific to different scrapie strains to facilitate differential prion protein misfolding. Since molecular cofactors may become integrated into the growing protein fibril during prion conversion, we have investigated the proteins contained in prion disease-specific deposits by shotgun proteomics of scrapie-associated fibrils (SAF) from mice infected with 3 different strains of mouse-passaged scrapie. Concomitant use of negative control preparations allowed us to identify and discount proteins that are enriched non-specifically by the SAF isolation protocol. We found several proteins that co-purified specifically with SAF from infected brains but none of these were reproducibly and demonstrably specific for particular scrapie strains. The α-chain of Na+/K+-ATPase was common to SAF from all 3 strains and we tested the ability of this protein to modulate in vitro misfolding of recombinant PrP. Na+/K+-ATPase enhanced the efficiency of disease-specific conversion of recombinant PrP suggesting that it may act as a molecular cofactor. Consistent with previous results, the same protein inhibited fibrillisation kinetics of recombinant PrP. Since functional interactions between PrPC and Na+/K+-ATPase have previously been reported in astrocytes, our data highlight this molecule as a key link between PrP function

  15. Toxoplasmosis, leptospirosis and brucellosis in stray dogs housed at the shelter in Umuarama municipality, Paraná, Brazil

    PubMed Central

    2013-01-01

    Background Leptospirosis, toxoplasmosis and brucellosis are diseases with worldwide distribution. Among stray dogs, these zoonoses are facilitated by direct contact with other animal species, by the habit of scavenging garbage and hunting in search of food, drinking standing water, smelling other animals’ urine, licking female genitalia and the sexual act itself. The objective of this study was to detect antibodies anti-Toxoplasma gondii, anti-Leptospira spp., anti-Brucella canis and anti-Brucella abortus in stray dogs housed in shelters at Umuarama city, Paraná, Brazil. In order to detect toxoplasmosis, indirect immunofluorescence assay (IFA) was performed, agglutination microscopic (MAT) test for leptospirosis and agar gel immunodiffusion (AGID) and buffered acidified antigen (BAA) tests for brucellosis. Results Of the 175 serum samples analyzed, 70.85% were considered positive for toxoplasmosis by IFA, 20% by MAT for leptospirosis and 2.85% by AGID for Brucella canis. Conclusions The serological results of this study showed that stray dogs housed at the private shelter are potential carriers of these three different zoonoses and contribute to the spread and maintenance of these etiologic agents in the urban area of Umuarama (PR), Brazil. PMID:24066949

  16. Brazil and the United States. Foreign Policy Association Headline Series No. 279.

    ERIC Educational Resources Information Center

    Lowenthal, Abraham F.

    One of a series, this booklet on world issues explains why Brazil has become important for the United States. Brazil's rise from a sleeping giant to continental leader is investigated. Brazil's impressive economic growth from the mid-1960s through the 1970s is explored. An analysis of Brazil's economic crisis of the 1980s is also explained.…

  17. 75 FR 67689 - Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... Brazil. See Antidumping Duty Orders: Stainless Steel Bar from Brazil, India and Japan, 60 FR 9661... Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review, 74 FR 10022 (March... Less Than Fair Value: Stainless Steel Bar From Brazil, 59 FR 66914 (December 28, 1994). These...

  18. 76 FR 12337 - Request for Applicants for Appointment to the United States-Brazil CEO Forum

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... International Trade Administration Request for Applicants for Appointment to the United States- Brazil CEO Forum... 2007, the Governments of the United States and Brazil established the U.S.-Brazil CEO Forum. This... Development, Industry and Foreign Trade, co-chair the U.S.-Brazil CEO Forum, pursuant to the Terms...

  19. 78 FR 32239 - Request for Applicants for Appointment to the United States-Brazil CEO Forum

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... International Trade Administration Request for Applicants for Appointment to the United States- Brazil CEO Forum... 2007, the Governments of the United States and Brazil established the U.S.-Brazil CEO Forum. This....-Brazil CEO Forum (Forum), pursuant to the Terms of Reference signed in March 2007 by the U.S....

  20. PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

    PubMed Central

    Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

    2016-01-01

    Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

  1. Family meals and eating practices among mothers in Santos, Brazil: A population-based study.

    PubMed

    Sato, Priscila de Morais; Lourenço, Bárbara Hatzlhoffer; Trude, Angela Cristina Bizzotto; Unsain, Ramiro Fernandez; Pereira, Patrícia Rocha; Martins, Paula Andrea; Scagliusi, Fernanda Baeza

    2016-08-01

    This study investigates family meals among mothers and explores associations between eating with family and sociodemographic characteristics, body mass index, and eating practices. A population-based cross-sectional study, using complex cluster-sampling, was conducted in the city of Santos, Brazil with 439 mothers. Frequency of family meals was assessed by asking if mothers did or did not usually have a) breakfast, b) lunch, and c) dinner with family. Linear regression analyses were conducted for the number of meals eaten with family per day and each of the potential explanatory variables, adjusting for the mother's age. Poisson regression with robust variance was used to analyze each factor associated with eating with family as classified categorically: a) sharing meals with family, b) not eating any meals with family. Only 16.4% (n = 72) of participants did not eat any meals with family. From the 83.6% (n = 367) of mothers that had at least one family meal per day, 69.70% (n = 306) ate dinner with their families. Mothers aged ≥40 years reported significantly fewer meals eaten with family compared to mothers aged 30-39 years (β: -0.26, p = 0.04). Having family meals was 54% more prevalent among mothers with ≥12 years of education (PR for no meals eaten with family: 0.54, 95% CI: 0.30; 0.96, p = 0.03), when compared to mothers with less than nine years of education. Eating no meals with family was 85% more prevalent among mothers who reported that eating was one of the biggest pleasures in their lives (PR: 1.85, 95% CI: 1.21; 2.82, p = 0.004). We suggest the need for further research investigating the effects of family meals on mothers' health through nutritional and phenomenological approaches. PMID:26994738

  2. Green and red luminescence in co-precipitation synthesized Pr:LuAG nanophosphor

    NASA Astrophysics Data System (ADS)

    Kumar, S. Arun; Kumar, K. Ashok; Gunaseelan, M.; Asokan, K.; Senthilselvan, J.

    2016-05-01

    Pr:LuAG nanophosphor is an effective candidate in magnetic resonance imaging coupled positron emission tomography (MRI-PET) for medical imaging and scintillator applications. LuAG:Pr (0.05, 0.15 mol%) nanoscale ceramic powders were synthesized by co-precipitation method using urea as precipitant. Effect of antisite defect on structure and luminescence behavior was investigated. Pr:LuAG nanoceramic powders are found crystallized in cubic structure by high temperature calcination at 1400 °C and it shows antisite defect. HR-SEM analysis revealed spherically shaped Pr:LuAG nanoceramic particulate powders with ˜100 nm size. By the excitation at 450 nm, Pr:LuAG nanophosphor exhibit green to red luminescence in the wavelength range of 520 to 680 nm, which is originated from multiplet transition of Pr3+ ions.

  3. Dzyaloshinsky-Moriya interaction in the enhanced nuclear magnet PrCu6

    NASA Astrophysics Data System (ADS)

    Ishii, Hiroumi; Kinoshita, Yasushi

    2001-01-01

    Recently it has been shown experimentally that the enhanced nuclear magnet PrCu6 behaves antiferromagnetically along the b axis and ferrromagnetically along the c axis. The mechanism for this anomalous magnetism is proposed here. The key lies in the crystal structure of PrCu6 with space group P21/c. In the unit cell there are two kinds of sites for Pr atoms. The neighboring atoms of one Pr are located at mirror reflection of those for another Pr. It is shown that between nuclear spins of these two Pr atoms the Dzyaloshinsky-Moriya type interaction is induced in the Ruderman-Kittel-Kasuya-Yosida interaction through the Van Vleck susceptibility. The susceptibility is calculated in the mean-field approximation, which reproduces the features of experimental results qualitatively.

  4. The matlockite-type praseodymium(III) oxide bromide PrOBr.

    PubMed

    Talmon-Gros, Pia; Schurz, Christian M; Schleid, Thomas

    2011-12-01

    The crystal structure of the praseodymium(III) oxide bromide, PrOBr, can be best described with layers of agglomerated square anti-prisms [PrO(4)Br(4)](9-). These slabs are stacked along the c axis and linked via two different secondary contacts between Pr(3+) and Br(-). The Pr(3+) cations occupy the Wyckoff site 2c with 4mm symmetry and carry four O(2-) anions as well as four primary Br(-) anions, yielding a coordination number of 8. While the Br(-) anions exhibit the same site symmetry as the Pr(3+) cations, the oxide anions are located at the Wyckoff position 2a with site symmetry [Formula: see text]m2 and have four Pr(3+) cations as neighbours, defining a tetra-hedron.

  5. Structural and magnetic properties of Pr-alloyed MnBi nanostructures

    SciTech Connect

    Kharel, P; Shah, VR; Li, XZ; Zhang, WY; Skomski, R; Shield, JE; Sellmyer, DJ

    2013-02-05

    The structural and magnetic properties of Pr-alloyed MnBi (short MnBi-Pr) nanostructures with a range of Pr concentrations are investigated. The nanostructures include thin films having Pr concentrations 0, 2, 3, 5 and 9 at.% and melt-spun ribbons having Pr concentrations 0%, 2%, 4% and 6%, respectively. Addition of Pr into the MnBi lattice has produced a significant change in the magnetic properties of these nanostructures including an increase in coercivity and structural phase transition temperature, and a decrease in saturation magnetization and anisotropy energy. The highest value of coercivity measured in the films is 23 kOe and in the ribbons is 5.6 kOe. The observed magnetic properties are explained as the consequences of competing ferromagnetic and antiferromagnetic interactions.

  6. Virulence testing and extracellular subtilisin-like (Pr1) and trypsin-like (Pr2) activity during propagule production of Paecilomyces fumosoroseus isolates from whiteflies (Homoptera: Aleyrodidae).

    PubMed

    Castellanos-Moguel, Judith; González-Barajas, Margarita; Mier, Teresa; Reyes-Montes, María Del Rocío; Aranda, Eduardo; Toriello, Conchita

    2007-03-01

    To properly characterize several isolates of Paecilomyces fumosoroseus, a fungal entomopathogen of whiteflies (Homoptera: Aleyrodidae) and other insect pests for biocontrol purposes, virulence towards Trialeurodes vaporariorum, and subtilisin-like (Pr1) and trypsin-like (Pr2) protease activity during propagule production were investigated in monospore cultures (MCs). The virulence of three MCs towards second instar whiteflies was measured and expressed as lethal median concentration (LC50). Number and widthlength ratio of propagules (blastospores, hyphal bodies, short hyphae, submerged conidia) and extracellular proteolytic activity was determined simultaneously in liquid medium. Total protease activity was assayed with azocasein, Pr1 and Pr2 activity was determined with the substrates N-Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide and N-Benzoyl-Phe-Val-Arg-pnitroanilide, respectively. Natural variability in virulence, propagule production and cuticle-degrading proteases among isolates was observed. Bioassays showed a LC50 of 1.1 x 1,000, 2.5 x 10,000 and 7.6 x 10,000 conidia/ml for MCs EH-506/3, EH-503/3 and EH-520/3, respectively, EH-506/3 being the most virulent isolate. Isolate EH-503/3 produced the highest yield of propagules (7.7 x 10000000 propagules/ml), followed by EH-520/3 with 6.4 x 10000000 and EH-506/3 with 1.0 x 10000000 propagules/ml. Subtilisin-like (Pr1) and trypsin-like (Pr2) activity was present in the three MCs. Subtilisin-like (Pr1) activity was highest (745.7 UPr1/ml at 120 h) in the most virulent isolate, EH-506/3, pointing at Pr1 as a phenotypic marker of virulence for P. fumosoroseus. EH-506/3 appears to be a good candidate for whitefly biocontrol due to its high virulence, Pr1 concentration and rapid transition to blastospores in submerged liquid medium.

  7. Filarioids infecting dogs in northeastern Brazil.

    PubMed

    Ramos, Rafael Antonio Nascimento; de Oliveira do Rêgo, Ana Gabriela; de Farias Firmino, Everton Diogo; do Nascimento Ramos, Carlos Alberto; de Carvalho, Gílcia Aparecida; Dantas-Torres, Filipe; Otranto, Domenico; Alves, Leucio Câmara

    2016-08-15

    Species of filarial nematodes belonging to the genera Dirofilaria and Acanthocheilonema are recognised as common parasites of dogs throughout the world. Recently, other filarioids featured by the presence of dermal microfilariae (e.g., Onchocerca lupi and Cercopithifilaria spp.) have been recognised in Europe. In Brazil, reports of filarioids in dogs are limited to Dirofilaria immitis, Acanthocheilonema reconditum and Cercopithifilaria bainae. To investigate the distribution of filarial infections in dogs living in an endemic region from northeastern Brazil, blood and skin samples (n=104) were microscopically (modified Knott's test and skin snip sediment examination) and molecularly evaluated. Twenty-two dogs (21.15%) were positive at microscopic and/or molecular examination for at least one filarioid species, with 21 (20.19%) animals positive for blood microfilariae at molecular and/or at microscopic examination. Microfilariae of D. immitis were detected in 12 (11.54%) animals, with co-infection of D. immitis and A. reconditum observed in four (3.85%) individuals. One animal was positive for C. bainae at both microscopic and molecular examination. Analysis of sequence obtained in the present study showed significant alignment identity with that of C. bainae from Europe. Considering that in the area of study arthropod vectors (mosquitoes, fleas and ticks) are prevalent throughout the year, preventive measures should be disposed in order to avoid the animal infestation and pathogen infection. PMID:27514878

  8. [Retrospect of tuberculosis control in Brazil].

    PubMed

    Hijjar, Miguel Aiub; Gerhardt, Germano; Teixeira, Gilmário M; Procópio, Maria José

    2007-09-01

    The aim of the study was to look back on the course of action involving measures of tuberculosis control in Brazil since the end of the 19th century, covering the history of social struggles and pointing out institutions and people that have dedicated themselves to looking for solutions to these issues. The Brazilian response to tuberculosis started in society with the Ligas Contra a Tuberculose (Leagues Against Tuberculosis), promoting scientific advances, such as the BCG vaccination, which begun in 1927. From the public power, the Inspetoria de Profilaxia da TB (TB Prophylaxis Inspection Service - 1920), the Serviço Nacional de Tuberculose (National Service of Tuberculosis - 1940), and the Campanha Nacional Contra a Tuberculose (National Campaign Against Tuberculosis - 1946), coordinated national policies such as chemotherapy, beginning with the discovery of streptomycin in 1944. The emergence of bacterial resistance led to the development of several therapeutic schemes. The Scheme 1 (rifampycin, hydrazide and pyrazinamid), which was the main one in 1979 and is still used nowadays, had a great epidemiological effect. The WHO declared TB a public health emergency in 1993. In response, Brazil developed some strategies; the first one was the Plano Emergencial para Controle da Tuberculose (Emergency Plan for Tuberculosis Control - 1994), prioritizing 230 municipalities. The current prospects are an effective municipalization of actions and their greater integration with the Programas de Agentes Comunitários e Saúde da Família (Humanitarian Agents and Family Health Programs).

  9. Workaholism in Brazil: measurement and individual differences.

    PubMed

    Romeo, Marina; Yepes-Baldó, Montserrat; Berger, Rita; Netto Da Costa, Francisco Franco

    2014-01-01

    The aim of this research is the measurement and assessment of individual differences of workaholism in Brazil, an important issue which affects the competitiveness of companies. The WART 15-PBV was applied to a sample of 153 managers from companies located in Brazil, 82 (53.6%) women and 71 (46.4%) men. Ages ranged from 20 to 69 years with an average value of 41 (SD=9.06). We analyzed, on one hand, the factor structure of the questionnaire, its internal consistency and convergent (with the Dutch Work Addiction Scale - DUWAS) and criterion validity (with General Health Questionnaire – GHQ). On the other hand, we analyzed individual gender differences on workaholism. WART15-PBV has good psychometric properties, and evidence for convergent and criterion validity. Females and males differed on Impaired Communication / Self-Absorption dimension. This dimension has a direct effect only on men’s health perception, while Compulsive tendencies dimension has a direct effect for both genders. The findings suggest the WART15-PBV is a valid measure of workaholism that would contribute to the workers’ health and their professional and personal life, in order to encourage adequate conditions in the workplace taking into account workers’ individual differences. PMID:25578002

  10. Brazil's Mixed Public and Private Hospital System.

    PubMed

    Lewis, Maureen; Penteado, Evandro; Malik, Ana Maria

    2015-01-01

    Brazil's hospital sector is vibrant and growing. Under the 1988 Brazilian constitution all citizens have the right to health care, anticipating the global commitment to Universal Health Care. Brazil's public sector prides itself on having one of the world's largest single payer health care systems, but complementing that is a significant and larger private sector that is seeing big increase in investment, utilization and prices. This article outlines the structure of the hospital system and analyzes the nature and direction of private health sector expansion. Twenty-six percent of Brazilians have private health insurance and although coverage is concentrated in the urban areas of the Southeastern part of the country, it is growing across the nation. The disease burden shift to chronic diseases affects the nature of demand and the directly affects overall health care costs, which are rising rapidly outstripping national inflation by a factor of 3. Increasingly costs will have to be brought under control to maintain the viability of the private sector. Adaption of integrated care networks and strengthening of the public reimbursement system represent important areas for improvement.

  11. Sugar-Sweetened Beverage Taxes in Brazil

    PubMed Central

    Levy, Renata B.; Popkin, Barry M.; Monteiro, Carlos A.

    2012-01-01

    Objectives. We investigated whether taxing sugar-sweetened beverages (SSBs) would improve the diets of households in Brazil. Methods. We used household food consumption data that the Brazilian Institute of Geography and Statistics collected in 2002–2003 from a nationally representative sample of 48 470 Brazilian households. The consumption of SSBs is expressed as the total SSB calories consumed and as the SSB percentage of the total calories purchased. We investigated price elasticity with regression models, controlling for demographic variables, income, and prices of all other foods and drinks. Results. Increases in the price of SSBs led to reductions in consumption. A 1.00% increase in the price of SSBs led to a 0.85% reduction of SSB calories consumed (1.03% reduction for the poor and 0.63% for the nonpoor). Increased income had a positive effect on SSB consumption, but the effect was less than half the size of the price elasticity (0.41% increase in SSB calories consumed for every 1.00% increase in income). Conclusions. High SSB price elasticity in Brazil indicates that a tax on purchased weight or volume would lead to reductions in SSB consumption. PMID:22095333

  12. Astrobiology in Brazil: early history and perspectives

    NASA Astrophysics Data System (ADS)

    Rodrigues, Fabio; Galante, Douglas; Paulino-Lima, Ivan G.; Duarte, Rubens T. D.; Friaça, Amancio C. S.; Lage, Claudia; Janot-Pacheco, Eduardo; Teixeira, Ramachrisna; Horvath, Jorge E.

    2012-10-01

    This review reports the Brazilian history in astrobiology, as well as the first delineation of a vision of the future development of the field in the country, exploring its abundant biodiversity, highly capable human resources and state-of-the-art facilities, reflecting the last few years of stable governmental investments in science, technology and education, all conditions providing good perspectives on continued and steadily growing funding for astrobiology-related research. Brazil is growing steadily and fast in terms of its worldwide economic power, an effect being reflected in different areas of the Brazilian society, including industry, technology, education, social care and scientific production. In the field of astrobiology, the country has had some important landmarks, more intensely after the First Brazilian Workshop on Astrobiology in 2006. The history of astrobiology in Brazil, however, is not so recent and had its first occurrence in 1958. Since then, researchers carried out many individual initiatives across the country in astrobiology-related fields, resulting in an ever growing and expressive scientific production. The number of publications, including articles and theses, has particularly increased in the last decade, but still counting with the effort of researchers working individually. That scenario started to change in 2009, when a formal group of Brazilian researchers working with astrobiology was organized, aiming at congregating the scientific community interested in the subject and to promote the necessary interactions to achieve a multidisciplinary work, receiving facilities and funding from the University de Sao Paulo and other funding agencies.

  13. Filarioids infecting dogs in northeastern Brazil.

    PubMed

    Ramos, Rafael Antonio Nascimento; de Oliveira do Rêgo, Ana Gabriela; de Farias Firmino, Everton Diogo; do Nascimento Ramos, Carlos Alberto; de Carvalho, Gílcia Aparecida; Dantas-Torres, Filipe; Otranto, Domenico; Alves, Leucio Câmara

    2016-08-15

    Species of filarial nematodes belonging to the genera Dirofilaria and Acanthocheilonema are recognised as common parasites of dogs throughout the world. Recently, other filarioids featured by the presence of dermal microfilariae (e.g., Onchocerca lupi and Cercopithifilaria spp.) have been recognised in Europe. In Brazil, reports of filarioids in dogs are limited to Dirofilaria immitis, Acanthocheilonema reconditum and Cercopithifilaria bainae. To investigate the distribution of filarial infections in dogs living in an endemic region from northeastern Brazil, blood and skin samples (n=104) were microscopically (modified Knott's test and skin snip sediment examination) and molecularly evaluated. Twenty-two dogs (21.15%) were positive at microscopic and/or molecular examination for at least one filarioid species, with 21 (20.19%) animals positive for blood microfilariae at molecular and/or at microscopic examination. Microfilariae of D. immitis were detected in 12 (11.54%) animals, with co-infection of D. immitis and A. reconditum observed in four (3.85%) individuals. One animal was positive for C. bainae at both microscopic and molecular examination. Analysis of sequence obtained in the present study showed significant alignment identity with that of C. bainae from Europe. Considering that in the area of study arthropod vectors (mosquitoes, fleas and ticks) are prevalent throughout the year, preventive measures should be disposed in order to avoid the animal infestation and pathogen infection.

  14. Workaholism in Brazil: measurement and individual differences.

    PubMed

    Romeo, Marina; Yepes-Baldó, Montserrat; Berger, Rita; Netto Da Costa, Francisco Franco

    2014-01-01

    The aim of this research is the measurement and assessment of individual differences of workaholism in Brazil, an important issue which affects the competitiveness of companies. The WART 15-PBV was applied to a sample of 153 managers from companies located in Brazil, 82 (53.6%) women and 71 (46.4%) men. Ages ranged from 20 to 69 years with an average value of 41 (SD=9.06). We analyzed, on one hand, the factor structure of the questionnaire, its internal consistency and convergent (with the Dutch Work Addiction Scale - DUWAS) and criterion validity (with General Health Questionnaire – GHQ). On the other hand, we analyzed individual gender differences on workaholism. WART15-PBV has good psychometric properties, and evidence for convergent and criterion validity. Females and males differed on Impaired Communication / Self-Absorption dimension. This dimension has a direct effect only on men’s health perception, while Compulsive tendencies dimension has a direct effect for both genders. The findings suggest the WART15-PBV is a valid measure of workaholism that would contribute to the workers’ health and their professional and personal life, in order to encourage adequate conditions in the workplace taking into account workers’ individual differences.

  15. The changing face of autism in Brazil.

    PubMed

    Rios, Clarice; Costa Andrada, Barbara

    2015-06-01

    At the end of 2012, after intensive lobbying by parent activist associations, a federal law recognized autism as a "disability for all legal purposes" in Brazil. Defining autism as a disability was more than a change of legal status to guarantee social benefits. It was also a political maneuver, orchestrated by parent associations, aimed to take the responsibility for treatment away from the public mental health network of services. This article examines the controversies that have set parent associations in direct antagonism with mental health professionals in the public health system. We draw from ethnographic data and theoretical discussions in the field of disability studies to situate these controversies within the context of a larger debate on the relationship between health, rights, and citizenship. We found similarities between the ethical and political goals of parent activists and mental health professionals in Brazil, but we argue that the main cause of dissent is the role that each of these social actors assigns to identity politics in their clinical and political projects.

  16. Mesothelioma mortality in Brazil, 1980-2003.

    PubMed

    Pedra, Francisco; Tambellini, Anamaria Testa; Pereira, Basílio de Bragança; da Costa, Ana Carolina Carioca; de Castro, Hermano Albuquerque

    2008-01-01

    Although asbestos causes asbestosis, lung cancer, and mesothelioma, it remains widely used in Brazil, mostly in cement-fiber products. We report the Brazilian mesothelioma mortality trend 1980-2003, using records of the national System of Mortality Information of DATASUS, including all deaths with IX International Disease Classification (ICD9) codes 163.n--pleura cancer during the period 1980-1995; and ICD10 codes c45.n--mesotheliomas and c38.4--pleura cancer for the years 1996-2003. Mesothelioma mortality rates increased over the period studied, from 0.56 to 1.01 deaths per 1,000,000 [corrected] habitants. The total number of mesothelioma deaths nationwide in the period studied was 2,414; the majority (1,415) were in the Southeast region. Mortality was highest among males and people over age 65. Given the history of asbestos exposure in Brazil, our findings support the need for policies that limit or ban the use of this product.

  17. Forensic entomology and main challenges in Brazil.

    PubMed

    Gomes, Leonardo; Von Zuben, Cláudio J

    2006-01-01

    Apart from an early case report from China (13th century), the first observations on insects and other arthropods as forensic indicators were documented in Germany and France during mass exhumations in the 1880s by Reinhard, who is considered a co-founder of the discipline. After the French publication of Mégnin's popular book on the applied aspects of forensic entomology, the concept quickly spread to Canada and United States. At that time, researchers recognized that the lack of systematic observations of insects of forensic importance jeopardized their use as indicators of postmortem interval. General advances in insect taxonomy and ecology helped to fill this gap over the following decades. After World Wars, few forensic entomology cases were reported in the scientific literature. From 1960s to the 1980s, Leclercq and Nuorteva were primarily responsible for maintaining the method in Central Europe, reporting isolated cases. Since then, basic research in the USA, Russia and Canada opened the way to the routine use of Entomology in forensic investigations. Identifications of insects associated with human cadavers are relatively few in the literature of the Neotropical region and have received little attention in Brazil. This article brings an overview of historic developments in this field, the recent studies and the main problems and challenges in South America and mainly in Brazil.

  18. Pediatric allergy and immunology in Brazil.

    PubMed

    Rosario-Filho, Nelson A; Jacob, Cristina M; Sole, Dirceu; Condino-Neto, Antonio; Arruda, Luisa K; Costa-Carvalho, Beatriz; Cocco, Renata R; Camelo-Nunes, Inês; Chong-Neto, Herberto J; Wandalsen, Gustavo F; Castro, Ana P M; Yang, Ariana C; Pastorino, Antonio C; Sarinho, Emanuel S

    2013-06-01

    The subspecialty of pediatric allergy and immunology in Brazil is in its early years and progressing steadily. This review highlights the research developed in the past years aiming to show the characteristics of allergic and immunologic diseases in this vast country. Epidemiologic studies demonstrated the high prevalence of asthma in infants, children, and adolescents. Mortality rates and average annual variation of asthma hospitalization have reduced in all pediatric age groups. Indoor aeroallergen exposure is excessively high and contributes to the high rates of allergy sensitization. Prevalence of food allergy has increased to epidemic levels. Foods (35%), insect stings (30%), and drugs (23%) are the main etiological agents of anaphylaxis in children and adolescents. Molecular diagnosis of primary immunodeficiencies (PID) showed a high incidence of fungal infections including paracoccidioidomycosis in X-linked hyper-IgM syndrome, and the occurrence of BCG adverse reactions or other mycobacterial infections in patients with chronic granulomatous disease. Education in pediatric allergy and immunology is deficient for medical students, but residency programs are effective in training internists and pediatricians for the practice of allergy. The field of PID requires further training. Last, this review is a tribute to Prof. Dr. Charles Naspitz, one of the pioneers of our specialty in Brazil.

  19. Ocular Gnathostomiasis in Brazil: A Case Report

    PubMed Central

    Chaves, Cláudia M.; Chaves, Claudio; Zoroquiain, Pablo; Belfort, Rubens; Burnier, Miguel N.

    2016-01-01

    Gnathostomiasis is a parasitic disease caused by nematode larvae ingestion of 15 known species of the genus Gnathostoma (one of the Gnathostomatidae family members). This parasite uses freshwater fish as a host and can infect - through the consumption of raw fish or their viscera - other animals such as dogs, cats, chickens, pigs, and humans. This parasitic disease, with humans acting as hosts, has been known since 1945 (India), and ocular complications have been known since 2004 (intravitreal; also described in India). Latin American countries, especially Mexico and Peru, have reported cases of the disease since 1970. The first dermatological case was reported in Brazil in 2009 (the individual had acquired the disease in Peru). This article describes the first reported ophthalmic case of the disease in Brazil and refers to a male patient, 30 years old, living in the municipality of Juruá, Amazonas State. The disease evolved within 30 days through a fistulized tumor in the inner corner of the lower eyelid. Following excision, the anatomical and histopathological examination revealed the presence of a different parasite species from other previously known genera. PMID:27239465

  20. [Historical evolution of package inserts in Brazil].

    PubMed

    Caldeira, Telma Rodrigues; Neves, Eugênio Rodrigo Zimmer; Perini, Edson

    2008-04-01

    In Brazil, package inserts provide key information on pharmaceuticals. The current study analyzes the evolution of package inserts and the impact on this process by scientific research and development, globalization of information, and various health policies. The study began with a retrospective review of Brazilian health legislation until 1920, the year when the National Public Health Department was created. The analysis of documents on the evolution of health regulation in Brazil began with the Brazilian Pharmaceutical Collection-Health Rulings. The second stage of the study involved a search of standards and norms in VISALEGIS: Health Surveillance Legislation, Portal for Legislation from the National Congressional Information System and the Health Legislation System. Package inserts became an important vehicle for information in the country and underwent important regulatory changes in the latter half of the 20th century. From 1946 to 2006, the number of mandatory items increased, with more in-depth description. However, the standardization of information for medicines with the same active ingredient failed to materialize, despite its importance and the various legal initiatives in this direction.

  1. Bullying during adolescence in Brazil: an overview.

    PubMed

    Pigozi, Pamela Lamarca; Machado, Ana Lúcia

    2015-11-01

    Bullying has been the subject of worldwide study for over four decades and is widely reported by social media. Despite this, the issue is a relatively new area of research in Brazil. This study analyzes academic literature addressing bullying produced in Brazil focusing on aspects that characterize this issue as a subtype of violence: gender differences, factors associated with bullying, consequences, and possible intervention and prevention approaches. The guiding question of this study was: what have Brazilian researchers produced regarding bullying among adolescents? The results show that over half of the studies used quantitative approaches, principally cross-sectional methods and questionnaires, and focused on determining the prevalence of and factors associated with bullying. The findings showed a high prevalence of bullying among Brazilian adolescents, an association between risk behavior and bullying, serious consequences for the mental health of young people, lack of awareness and understanding among adolescents about bullying and its consequences, and a lack of strategies to manage this type of aggression. There is a need for intervention studies, prevention and restorative practices that involve the community and can be applied to everyday life at school. PMID:26602728

  2. [Blood regulation in Brazil: contextualization for improvement].

    PubMed

    Silva Júnior, João Batista; Costa, Christiane da Silva; Baccara, João Paulo de Araújo

    2015-10-01

    The use of blood products as essential medicines and the recognition of the high risk associated with blood transfusions require governments to take regulatory action with a focus on quality and safety. In this scenario, regulatory agencies play an essential role in socially advancing the guarantee that blood components will be produced according to current operating rules. Thus, in the effort to manage sanitary risks involved in the processing and use of blood, the Brazilian regulatory model, based on the construction of a national blood policy overseen by the State, has undergone conceptual improvement and review of the tools employed to achieve its goals. With the inclusion of good manufacturing practices as part of the Brazilian norms, as recommended by the World Health Organization, the country has moved forward in its view of blood facilities as manufacturing centers producing blood-derived biologics for therapeutic applications. It has also strengthened the need to develop safety mechanisms for blood donors and recipients. The development of a State-coordinated national blood policy and the institution of a national surveillance system with legitimate power of inspection are essential elements used in Brazil to guarantee the amount, quality, safety, and timeliness of blood supply to the population. The present article aims to discuss the present context of the blood regulatory model in Brazil so as to identify the challenges for improvement of this model. PMID:26758225

  3. Implementation of thermographers' certification in Brazil

    NASA Astrophysics Data System (ADS)

    dos Santos, Laerte; Alves, Luiz M.; da Costa Bortoni, Edson

    2011-05-01

    In recent years Brazil has experienced extraordinary growth despite the recent economic global crisis. The demand for infrared thermography products and services has accompanied this growth. Like other non-destructive testing and inspection, the results obtained by thermography are highly dependent on the skills of thermographer. Therefore, it is very important to establish a serious and recognized process of certification to assess thermographers' qualifications and help services suppliers to establish credibility with their customers and increase the confidence of these costumers on the quality of these services. The Brazilian Society of Non-Destructive Testing and Inspection, ABENDI, a non-profitable, private technical-scientific entity, recognized nationally and internationally, has observed the necessity of starting a process for certification of thermographers in Brazil. With support of a work group composed by experts from oil and energy industries, transportation, universities and manufactures, the activities started in 2005. This paper describes the economic background required for installation of the certification process, its initial steps, the main characteristics of the Brazilian certification and the expectation for initiating the certification process.

  4. Ichthyofauna Used in Traditional Medicine in Brazil

    PubMed Central

    El-Deir, Ana Carla Asfora; Collier, Carolina Alves; de Almeida Neto, Miguel Santana; Silva, Karina Maria de Souza; Policarpo, Iamara da Silva; Araújo, Thiago Antonio S.; Alves, Rômulo Romeu Nóbrega; de Albuquerque, Ulysses Paulino; de Moura, Geraldo Jorge Barbosa

    2012-01-01

    Fish represent the group of vertebrates with the largest number of species and the largest geographic distribution; they are also used in different ways by modern civilizations. The goal of this study was to compile the current knowledge on the use of ichthyofauna in zootherapeutic practices in Brazil, including ecological and conservational commentary on the species recorded. We recorded a total of 85 species (44 fresh-water species and 41 salt-water species) used for medicinal purposes in Brazil. The three most commonly cited species were Hoplias malabaricus, Hippocampus reidi, and Electrophorus electricus. In terms of conservation status, 65% of species are in the “not evaluated” category, and 14% are in the “insufficient data” category. Three species are in the “vulnerable” category: Atlantoraja cyclophora, Balistes vetula, and Hippocampus erectus. Currently, we cannot avoid considering human pressure on the population dynamics of these species, which is an essential variable for the conservation of the species and the ecosystems in which they live and for the perpetuation of traditional medical practices. PMID:22454668

  5. Dengue viruses in Brazil, 1986-2006.

    PubMed

    Nogueira, Rita Maria Ribeiro; de Araújo, Josélio Maria Galvão; Schatzmayr, Hermann Gonçalves

    2007-11-01

    A total of 4,243,049 dengue cases have been reported in Brazil between 1981 and 2006, including 5,817 cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and a total of 338 fatal cases. Although all Brazilian regions have been affected, the Northeast and Southeast regions have registered the highest number of notifications. DENV-1 and DENV-4 were isolated for the first time in the Amazon region of Brazil in 1981 and 1982. The disease became a nationwide public health problem following outbreaks of DENV-1 and DENV-2 in the state of Rio de Janeiro in 1986 and 1990, respectively. The introduction of DENV-3 in 2000, also in the state of Rio de Janeiro, led to a severe epidemic with 288 245 reported dengue cases, including 91 deaths. Virus strains that were typed during the 2002 epidemic show that DENV-3 has displaced other dengue virus serotypes and entered new areas, a finding that warrants closer evaluation. Unusual clinical symptoms, including central nervous system involvement, have been observed in dengue patients in at least three regions of the country.

  6. The elimination of Chagas' disease from Brazil

    PubMed Central

    MASSAD, E.

    2008-01-01

    SUMMARY On 9 June 2006 the Pan American Health Organization (PAHO) presented the Minister of Health of Brazil with the International Elimination of Transmission of Chagas' Disease Certificate. This act was the culmination of an intensive process that began in 1991 with the Southern Cone Initiative, a joint agreement between the governments of Argentina, Bolivia, Brazil, Chile, Paraguay, Uruguay and Peru, to control Chagas' disease by the elimination of the main vector, Triatoma infestans. This initiative has been highly successful and the prevalence area of the vector diminished rapidly in the last years. As a consequence, the current seroprevalence in children aged between 0 and 5 years is of the order of 10−5, a clear indication that transmission, if it is occurring, is only accidental. In this review I calculate the basic reproduction number, R0, for Chagas' disease and demonstrate that its relatively low value (1·25) explains why vectorial transmission was interrupted relatively easily. In addition, I used a mathematical model to forecast how long the remaining cases of the disease, as well as the additional vertically transmitted cases will last. PMID:18053273

  7. Fetal deaths in Brazil: a systematic review

    PubMed Central

    Barbeiro, Fernanda Morena dos Santos; Fonseca, Sandra Costa; Tauffer, Mariana Girão; Ferreira, Mariana de Souza Santos; da Silva, Fagner Paulo; Ventura, Patrícia Mendonça; Quadros, Jesirée Iglesias

    2015-01-01

    OBJECTIVE To review the frequency of and factors associated with fetal death in the Brazilian scientific literature. METHODS A systematic review of Brazilian studies on fetal deaths published between 2003 and 2013 was conducted. In total, 27 studies were analyzed; of these, 4 studies addressed the quality of data, 12 were descriptive studies, and 11 studies evaluated the factors associated with fetal death. The databases searched were PubMed and Lilacs, and data extraction and synthesis were independently performed by two or more examiners. RESULTS The level of completeness of fetal death certificates was deficient, both in the completion of variables, particularly sociodemographic variables, and in defining the underlying causes of death. Fetal deaths have decreased in Brazil; however, inequalities persist. Analysis of the causes of death indicated maternal morbidities that could be prevented and treated. The main factors associated with fetal deaths were absent or inadequate prenatal care, low education level, maternal morbidity, and adverse reproductive history. CONCLUSIONS Prenatal care should prioritize women that are most vulnerable (considering their social environment or their reproductive history and morbidities) with the aim of decreasing the fetal mortality rate in Brazil. Adequate completion of death certificates and investment in the committees that investigate fetal and infant deaths are necessary. PMID:25902565

  8. Bullying during adolescence in Brazil: an overview.

    PubMed

    Pigozi, Pamela Lamarca; Machado, Ana Lúcia

    2015-11-01

    Bullying has been the subject of worldwide study for over four decades and is widely reported by social media. Despite this, the issue is a relatively new area of research in Brazil. This study analyzes academic literature addressing bullying produced in Brazil focusing on aspects that characterize this issue as a subtype of violence: gender differences, factors associated with bullying, consequences, and possible intervention and prevention approaches. The guiding question of this study was: what have Brazilian researchers produced regarding bullying among adolescents? The results show that over half of the studies used quantitative approaches, principally cross-sectional methods and questionnaires, and focused on determining the prevalence of and factors associated with bullying. The findings showed a high prevalence of bullying among Brazilian adolescents, an association between risk behavior and bullying, serious consequences for the mental health of young people, lack of awareness and understanding among adolescents about bullying and its consequences, and a lack of strategies to manage this type of aggression. There is a need for intervention studies, prevention and restorative practices that involve the community and can be applied to everyday life at school.

  9. Excited states of154Nd studied through the decay of154Pr

    NASA Astrophysics Data System (ADS)

    Toh, Y.; Okano, K.; Taniguchi, A.; Yamada, S.; Kawase, Y.

    1996-12-01

    The neutron-rich isotope154Pr, the heaviest isotope of praseodymium, has been investigated by γ-ray multispectrum scaling and γ-γ-(t), X-γ-(t) coincidence experiments. The isotope154Pr was separated from235U fission products with the on-line isotope separator KUR-ISOL. The decay scheme of154Pr has been constructed consisting of 9 excited states and 12 transitions in154Nd, including 7 excited states newly found in the present experiment.

  10. Photoelectron spectrum of PrO{sup −}

    SciTech Connect

    Kafader, Jared O.; Ray, Manisha; Jarrold, Caroline Chick

    2015-08-14

    The photoelectron (PE) spectrum of PrO{sup −} exhibits a short 835 ± 20 cm{sup −1} vibrational progression of doublets (210 ± 30 cm{sup −1} splitting) assigned to transitions from the 4f{sup 2} [{sup 3}H{sub 4}] σ{sub 6s}{sup 2} Ω = 4 anion ground state to the 4f{sup 2} [{sup 3}H{sub 4}] σ{sub 6s} Ω = 3.5 and 4.5 neutral states. This assignment is analogous to that of the recently reported PE spectrum of CeO{sup −}, though the 82 cm{sup −1} splitting between the 4f [{sup 2}F{sub 2.5}] σ{sub 6s} Ω = 2 and Ω = 3 CeO neutral states could not be resolved [Ray et al., J. Chem. Phys. 142, 064305 (2015)]. The origin of the transition to the Ω = 3.5 neutral ground state is 0.96 ± 0.01 eV, which is the adiabatic electron affinity of PrO. Density functional theory calculations on the anion and neutral molecules support the assignment. The appearance of multiple, irregularly spaced and low-intensity features observed ca. 1 eV above the ground state cannot be reconciled with low-lying electronic states of PrO that are accessible via one-electron detachment. However, neutral states correlated with the 4f{sup 2} [{sup 3}H{sub 4}] 5d superconfiguration are predicted to be approximately 1 eV above the 4f{sup 2} [{sup 3}H{sub 4}] σ{sub 6s} Ω = 3.5 neutral ground state, leading to the assignment of these features to shake-up transitions to the excited neutral states. Based on tentative hot band transition assignments, the term energy of the previously unobserved 4f{sup 2} [{sup 3}H{sub 4}] σ{sub 6s} Ω = 2.5 neutral state is determined to be 1840 ± 110 cm{sup −1}.

  11. Phenology and global warming research in Brazil

    NASA Astrophysics Data System (ADS)

    Morellato, L. P. C.

    2009-04-01

    A recent review on South American phenology research has shown an increase in phenology papers over the last two decades, especially in this new 21st century. Nevertheless, there is a lack of long term data sets or monitoring systems, or of papers addressing plant phenology and global warming. The IPCC AR4 report from 2007 has offered indisputable evidence of regional to global-scale change in seasonality, but it is supported by plant and animal phenological data from North Hemisphere and temperate species. Information from tropical regions in general and South America in particular are sparse or lacking. Here I summarize the recent outcomes of our ongoing tropical phenology research in Brazil and its potential contribution to integrate fields and understand the effects of global warming within the tropics. The Phenology Laboratory (UNESP) is located at Rio Claro, São Paulo State, Southeastern Brazil. We are looking for trends and shifts on tropical vegetation phenology, and are exploring different methods for collecting and analyzing phenology data. The phenological studies are developed in collaboration with graduate and undergraduate students, post-docs and researchers from Brazil and around the world. We established three long term monitoring programs on Southeastern Brazil from 2000 onwards: trees from an urban garden, semideciduous forest trees, and savanna cerrado woody vegetation, all based on direct weekly to monthly observation of marked plants. We have collected some discontinuous data from Atlantic rain forest trees ranging from 5 to 8 years long. I collaborate with the longest tropical wet forest phenology monitoring system in Central Amazon, and with another long term monitoring system on semi deciduous forest from South Brazil. All research programs aim, in the long run, to monitor and detect shifts on tropical plant phenology related to climatic changes. Our first preliminary findings suggest that: (i) flowering and leafing are more affected by

  12. [Work and psychological distress among public school teachers in Vitória da Conquista, Bahia State, Brazil].

    PubMed

    dos Reis, Eduardo José Farias Borges; Carvalho, Fernando Martins; de Araújo, Tânia Maria; Porto, Lauro Antônio; Silvany Neto, Annibal Muniz

    2005-01-01

    A cross-sectional study with all the teachers in the municipal school system in Vitória da Conquista, Bahia State, Brazil, investigated the association between work content (psychological demand and control over work) and the occurrence of minor psychiatric disorders (MPD) among teachers. The Karasek demand-control model was used to evaluate control over work. The Self-Report Questionnaire-20 was used to evaluate minor psychiatric disorders. MPD prevalence was 55.9% among the 808 teachers studied. Crude prevalence of MPD showed a positive and significant association with psychological demand and a negative and significant association with control over work. MPD prevalence was higher in teachers with highly demanding work, characterized by heavy demand and low control (PR = 1.74; 95%CI: 1.44-2.10), and in those with active work, with heavy demand and low control (PR = 1.35; 95%CI: 1.13-1.61), as compared to teachers with low-demand work (light demand and high control), after adjusting for confounders in a multiple logistic regression model. As a conclusion, teachers' mental health is strongly associated with their work content.

  13. Genetic diversity and primary resistance among HIV-1-positive patients from Maringá, Paraná, Brazil.

    PubMed

    Gaspareto, Karine Vieira; Mello, Flávia Myrian Martins de Almeida; Dias, José Ricardo Colleti; Meneguetti, Vera Alice Fernandes; Storti, Marta Evelyn Giansante; Ferreira, João Leandro de Paula; Lança, André Minhoto; Rodrigues, Rosângela; Brígido, Luis Fernando de Macedo; Teixeira, Jorge Juarez Vieira; Bertolini, Dennis Armando

    2012-08-01

    The objective of this study is to identify subtypes of Human Immunodeficiency Virus type 1 (HIV-1) and to analyze the presence of mutations associated to antiretroviral resistance in the protease (PR) and reverse transcriptase (RT) regions from 48 HIV-1 positive treatment naïve patients from an outpatient clinic in Maringá, Paraná, Brazil. Sequencing was conducted using PR, partial RT and group-specific antigen gene (gag) nested PCR products from retrotranscribed RNA. Transmitted resistance was determined according to the Surveillance Drug Resistance Mutation List (SDRM) algorithm. Phylogenetic and SimPlot analysis of concatenated genetic segments classified sequences as subtype B 19/48 (39.6%), subtype C 12/48 (25%), subtype F 4/48 (8.3%), with 13/48 (27.1%) recombinant forms. Most recombinant forms were B mosaics (B/F 12.5%, B/C 10.4%), with one C/F (2.1%) and one complex B/C/F mosaic (2.1%). Low levels of transmitted resistance were found in this study, 2/48 (2.1% to NRTIs and 2.1% for PI). This preliminary data may subsidize the monitoring of the HIV evolution in the region.

  14. Electro-oxidation of ethanol on ternary non-alloyed Pt-Sn-Pr/C catalysts

    NASA Astrophysics Data System (ADS)

    Corradini, Patricia G.; Antolini, Ermete; Perez, Joelma

    2015-02-01

    Ternary Pt-Sn-Pr/C (70:10:20), (70:15:15) and (45:45:10) electro-catalysts were prepared by a modified formic acid method, and their activity for the ethanol oxidation reaction (EOR) was compared with that of Pt-Pr/C catalysts prepared by the same methods and that of commercial Pt-Sn/C (75:25) and Pt/C catalysts. Among all the catalysts, the Pt-Sn-Pr/C (45:45:10) catalyst presented both the highest mass activity and the highest specific activity. The steady state electrochemical stability of ternary Pt-Sn-Pr catalysts increased with the surface Sn/Pt atomic ratio. Following repetitive potential cycling (RPC), the activity for ethanol oxidation of Pt-Sn-Pr/C catalysts with high surface Sn/Pt atomic ratio was considerably higher than that of the corresponding as-prepared catalysts, and increased with increasing the Sn/Pt ratio. The increase of the EOR mass activity following RPC was ascribed to the increase of either the specific activity (for the Pt-Sn-Pr/C (70:15:15) catalyst) or the electrochemically active surface area (for the Pt-Sn-Pr/C (45:45:10) catalyst). Dissolution of Sn and Pr oxides from Pt-Sn-Pr/C catalyst surface was observed following RPC.

  15. Anomalous Schottky specific heat and structural distortion in ferromagnetic PrAl2.

    PubMed

    Pathak, Arjun K; Paudyal, D; Mudryk, Y; Gschneidner, K A; Pecharsky, V K

    2013-05-01

    Unique from other rare earth dialuminides, PrAl(2) undergoes a cubic to tetragonal distortion below T = 30 K in a zero magnetic field, but the system recovers its cubic symmetry upon the application of an external magnetic field of 10 kOe via a lifting of the 4f crystal field splitting. The nuclear Schottky specific heat in PrAl(2) is anomalously high compared to that of pure Pr metal. First principles calculations reveal that the 4f crystal field splitting in the tetragonally distorted phase of PrAl(2) underpins the observed unusual low temperature phenomena.

  16. Case studies in international tobacco surveillance: cigarette smuggling in Brazil

    PubMed Central

    Shafey, O; Cokkinides, V; Cavalcante, T; Teixeira, M; Vianna, C; Thun, M

    2002-01-01

    Objective: This article is the first in a series of international case studies developed by the American Cancer Society to illustrate use of publicly available surveillance data for regional tobacco control. Design: A descriptive analysis of Brazil and Paraguay cigarette production and trade data from official sources. Methods: Per capita cigarette consumption for Brazil and its neighbour was calculated from 1970 to 1998 using data on production, imports, and exports from NATIONS, the National Tobacco Information Online System. Results: A 63% decrease was observed in the estimate of per capita consumption of cigarettes in Brazil between 1986 and 1998 (from 1913 cigarettes per person in 1986 to 714 cigarettes per person in 1998) and a 16-fold increase in Paraguay was observed during the same period (from 678 cigarettes per person in 1986 to 10 929 cigarettes per person in 1998). Following Brazil's 1999 passage of a 150% cigarette export tax, cigarette exports fell 89% and Brazil's estimated per capita consumption rose to 1990 levels (based on preliminary data). Per capita consumption in Paraguay also fell to 1990 levels. Conclusions: These trends coincide with local evidence that large volumes of cigarettes manufactured in Brazil for export to Paraguay are smuggled back and consumed as tax-free contraband in Brazil. It is hoped that this case study will draw wider public attention to the problems that smuggling presents for tobacco control, help identify other countries confronting similar issues, and stimulate effective interventions. PMID:12198271

  17. Bayesian reconstruction of projection reconstruction NMR (PR-NMR).

    PubMed

    Yoon, Ji Won

    2014-11-01

    Projection reconstruction nuclear magnetic resonance (PR-NMR) is a technique for generating multidimensional NMR spectra. A small number of projections from lower-dimensional NMR spectra are used to reconstruct the multidimensional NMR spectra. In our previous work, it was shown that multidimensional NMR spectra are efficiently reconstructed using peak-by-peak based reversible jump Markov chain Monte Carlo (RJMCMC) algorithm. We propose an extended and generalized RJMCMC algorithm replacing a simple linear model with a linear mixed model to reconstruct close NMR spectra into true spectra. This statistical method generates samples in a Bayesian scheme. Our proposed algorithm is tested on a set of six projections derived from the three-dimensional 700 MHz HNCO spectrum of a protein HasA. PMID:25218584

  18. Magnetic excitations in single crystal PrNiSn

    NASA Astrophysics Data System (ADS)

    Beirne, E. D.; McEwen, K. A.; Habicht, K.; Fort, D.

    Inelastic neutron scattering results from a single crystal of the rare earth intermetallic PrNiSn are presented. Crystalline electric field excitations are found at 0.5, 2.4 and around 3.5 meV. The lower modes show little dispersion over q, but the 3.5 meV splits into two excitations, most clearly seen along the c* direction. Fitting the modes with gaussian functions allows us to show the pronounced dispersion to be of the form E(q)=E0+J1cos(qπ) for the upper mode, and E(q)=E0+J1cos(qπ)+J2cos(2qπ) for the lower mode. This suggests a longer range interaction for the lower mode. The lowest excitation at 0.5 meV confirms predictions made from previous measurements on polycrystalline samples that indicate a low lying CEF level.

  19. Beta Decay of 151Pr into Levels in 151Nd

    NASA Astrophysics Data System (ADS)

    Shibata, Michihiro; Ikuta, Tomohiko; Taniguchi, Akihiro; Osa, Akihiko; Tanaka, Akihiko; Yamamoto, Hiroshi; Kawade, Kiyoshi; Ruan, Jian-Zhi; Kawase, Yoichi; Okano, Kotoyuki

    1994-09-01

    The β-decay of 151 59Pr92 to the levels in 151 60Nd91 has been studied from the fission products of 235U using an on-line isotope separator (KUR-ISOL). Gamma-rays and conversion electrons have been measured. Conversion coefficients have been determined for the first time. The precise decay scheme is proposed up to 2430 keV. The newly observed 65 γ-rays and 16 levels are incorporated in it. The deduced level scheme of 151Nd was compared to the calculated level scheme on the basis of the rotation-vibration coupling model with a Nilsson potential. Low-lying levels were well reproduced by this model.

  20. Seroprevalence of Brucella ovis in rams and associated flock level risk factors in the state of Rio Grande do Sul, Brazil.

    PubMed

    Machado, G; Santos, D V; Kohek, I; Stein, M C; Hein, H E; Poeta, A S; Vidor, A C M; Corbellini, L G

    2015-09-01

    A cross-sectional study based on a planned probabilistic sampling was carried out to estimate animal and flock prevalence of Brucella ovis in rams, as well as to determine risk factors at the flock level. Data regarding the flocks were collected by means of a questionnaire applied on 705 farms in the state of Rio Grande do Sul, Brazil, using one-stage cluster sampling. From the 705 flocks, 20 (2.5%, CI95%: 2.0-3.1%) had at least one positive ram. At the animal level, out of 1800 rams, 52 were positive (2.89%, CI95%: 0.4-5.3%). Statistical analysis identified the following as risk factors: average age of rams in the flocks (PR: 1.99, CI95%: 1.19-3.32); farms larger than 5 km(2) (500 ha) on extension area (PR: 7.46CI95%: 2.03-27.43); and the lack of lambing paddocks (PR: 5.56, CI95%: 1.70-18.11). This study provided relevant information for authorities to elaborate plans for the first Brazilian state based B. ovis disease control and eradication program. To the authors' knowledge, this is the first study that shows the importance of lambing paddocks in order to keep pre-lambing and lambing ewes away from the rest of the flock, the lack of this infrastructure was considered an important risk factor for B. ovis.

  1. Pediatric Hospital: The Paradigms of Play in Brazil.

    PubMed

    de Macedo, Lino; da Silva, Gláucia Faria; Setúbal, Sandra Mutarelli

    2015-01-01

    The role of play in Brazilian children's hospitals is highlighted, as well as the perspective of humanization in Brazil. Some aspects of our culture are crucial to understanding the importance of play considering our society. Sabara Children's Hospital ("Hospital Infantil Sabará") in Brazil is used particularly to discuss humanization. To understand the issue of play in Brazil, it is important to discuss hospitals in their social context, their history, current roles in children's care, humanization history and child development, according to the approaches of Piaget and Winnicott that are used in our culture. PMID:27417350

  2. Pediatric Hospital: The Paradigms of Play in Brazil

    PubMed Central

    de Macedo, Lino; Faria da Silva, Gláucia; Mutarelli Setúbal, Sandra

    2015-01-01

    The role of play in Brazilian children’s hospitals is highlighted, as well as the perspective of humanization in Brazil. Some aspects of our culture are crucial to understanding the importance of play considering our society. Sabara Children’s Hospital (“Hospital Infantil Sabará”) in Brazil is used particularly to discuss humanization. To understand the issue of play in Brazil, it is important to discuss hospitals in their social context, their history, current roles in children’s care, humanization history and child development, according to the approaches of Piaget and Winnicott that are used in our culture. PMID:27417350

  3. Achyrocline satureioides essential oils from southern Brazil and Uruguay.

    PubMed

    Lorenzo, D; Atti-Serafini, L; Santos, A C; Frizzo, C D; Paroul, N; Paz, D; Dellacassa, E; Moyna, P

    2000-06-01

    The essential oils of the aerial parts of Achyrocline satureioides (D.C.) Lam., a regional medicinal plant, from different collection locations in the South of Brazil and Uruguay were examined by GC and GC-MS. Monoterpene and sesquiterpene hydrocarbons were the main fractions of both the oils from Brazil and Uruguay. The oxygenated monoterpenes and sequiterpenes were at much lower percentage in both samples. The Uruguayan samples have 1,8-cineole which is not present in the Brazilian samples and has not been reported in other samples from Brazil. The results indicated a high biodiversity of the native populations of A. satureioides.

  4. A Checklist of the Gyrinidae (Coleoptera: Adephaga) of Brazil.

    PubMed

    Colpani, Daniara; Benetti, Cesar João; Hamada, Neusa

    2014-01-01

    A checklist of all known species of the water beetle family Gyrinidae (whirligig beetles) recorded from Brazil is assembled. This checklist is based on literature published prior to 2012. A total of 206 species and subspecies are cited for Brazil, distributed among three genera (Enhydrus Laporte, 1834, Gyrinus Geoffroy, 1762 and Gyretes Brullé, 1835). For each species we also include a complete account of its nomenclature including synonyms and historical combinations. The geographical distribution of each species both inside and outside of Brazil is provided. PMID:25544139

  5. Pediatric Hospital: The Paradigms of Play in Brazil.

    PubMed

    de Macedo, Lino; da Silva, Gláucia Faria; Setúbal, Sandra Mutarelli

    2015-01-29

    The role of play in Brazilian children's hospitals is highlighted, as well as the perspective of humanization in Brazil. Some aspects of our culture are crucial to understanding the importance of play considering our society. Sabara Children's Hospital ("Hospital Infantil Sabará") in Brazil is used particularly to discuss humanization. To understand the issue of play in Brazil, it is important to discuss hospitals in their social context, their history, current roles in children's care, humanization history and child development, according to the approaches of Piaget and Winnicott that are used in our culture.

  6. Foam pigs solve pipe cleaning problems offshore Brazil

    SciTech Connect

    Lima, P.C.R.; Neto, S.J.A.

    1995-10-02

    Pipeline systems in which conventional pigs cannot be run are common in such complex offshore installations as are found in Brazil`s Campos basin. These systems may contain changing pipe diameters or wet christmas trees and manifolds. A new concept for using low cost, low-density foam pigs for both liquid removal in wet-gas pipelines and paraffin removal in oil and multiphase pipelines has been successfully tested offshore Brazil. Although the present discussion focuses on condensate and paraffin removal in pipelines, the principles can be applied to several kinds of operations including general pipeline cleaning, product removal or separation in pipeline, corrosion evaluation, and chemical product application.

  7. Asian genotypes of dengue virus 4 in Brazil.

    PubMed

    Pinho, A C O; Sardi, S I; Paula, F L; Peixoto, I B; Brandão, C J; Fernandez, F M C; Campos, G S

    2015-10-01

    Dengue virus, commonly transmitted by mosquitoes, causes a human disease of significant social impact and presents a serious public health problem in Brazil. This report describes the unusual emergence of DENV-4 in northern Brazil after a nearly 30-year-long absence. DENV-4 genotype I is of Asian origin and was identified in the serum of patients receiving treatment at a hospital serving the Salvador area (Brazilian state of Bahia). The identification of dengue virus serotypes through molecular and phylogenetic analysis is essential for predicting disease severity or fatal illness, principally in endemic countries such as Brazil.

  8. Distribution of peripheral PrP(Sc) in sheep with naturally acquired scrapie.

    PubMed

    Garza, María Carmen; Monzón, Marta; Marín, Belén; Badiola, Juan José; Monleón, Eva

    2014-01-01

    Accumulation of prion protein (PrPSc) in the central nervous system is the hallmark of transmissible spongiform encephalopathies. However, in some of these diseases such as scrapie or chronic wasting disease, the PrPSc can also accumulate in other tissues, particularly in the lymphoreticular system. In recent years, PrPSc in organs other than nervous and lymphoid have been described, suggesting that distribution of this protein in affected individuals may be much larger than previously thought. In the present study, 11 non-nervous/non-lymphoid organs from 16 naturally scrapie infected sheep in advanced stages of the disease were examined for the presence of PrPSc. Fourteen infected sheep were of the ARQ/ARQ PRNP genotype and 2 of the VRQ/VRQ, where the letters A, R, Q, and V represent the codes for amino-acids alanine, arginine, glutamine and valine, respectively. Adrenal gland, pancreas, heart, skin, urinary bladder and mammary gland were positive for PrPSc by immunohistochemistry and IDEXX HerdChek scrapie/BSE Antigen EIA Test in at least one animal. Lung, liver, kidney and skeletal muscle exhibited PrPSc deposits by immunohistochemistry only. To our knowledge, this is the first report regarding the presence of PrPSc in the heart, pancreas and urinary bladder in naturally acquired scrapie infections. In some other organs examined, in which PrPSc had been previously detected, PrPSc immunolabeling was observed to be associated with new structures within those organs. The results of the present study illustrate a wide dissemination of PrPSc in both ARQ/ARQ and VRQ/VRQ infected sheep, even when the involvement of the lymphoreticular system is scarce or absent, thus highlighting the role of the peripheral nervous system in the spread of PrPSc.

  9. Distribution of Peripheral PrPSc in Sheep with Naturally Acquired Scrapie

    PubMed Central

    Garza, María Carmen; Monzón, Marta; Marín, Belén; Badiola, Juan José; Monleón, Eva

    2014-01-01

    Accumulation of prion protein (PrPSc) in the central nervous system is the hallmark of transmissible spongiform encephalopathies. However, in some of these diseases such as scrapie or chronic wasting disease, the PrPSc can also accumulate in other tissues, particularly in the lymphoreticular system. In recent years, PrPSc in organs other than nervous and lymphoid have been described, suggesting that distribution of this protein in affected individuals may be much larger than previously thought. In the present study, 11 non-nervous/non-lymphoid organs from 16 naturally scrapie infected sheep in advanced stages of the disease were examined for the presence of PrPSc. Fourteen infected sheep were of the ARQ/ARQ PRNP genotype and 2 of the VRQ/VRQ, where the letters A, R, Q, and V represent the codes for amino-acids alanine, arginine, glutamine and valine, respectively. Adrenal gland, pancreas, heart, skin, urinary bladder and mammary gland were positive for PrPSc by immunohistochemistry and IDEXX HerdChek scrapie/BSE Antigen EIA Test in at least one animal. Lung, liver, kidney and skeletal muscle exhibited PrPSc deposits by immunohistochemistry only. To our knowledge, this is the first report regarding the presence of PrPSc in the heart, pancreas and urinary bladder in naturally acquired scrapie infections. In some other organs examined, in which PrPSc had been previously detected, PrPSc immunolabeling was observed to be associated with new structures within those organs. The results of the present study illustrate a wide dissemination of PrPSc in both ARQ/ARQ and VRQ/VRQ infected sheep, even when the involvement of the lymphoreticular system is scarce or absent, thus highlighting the role of the peripheral nervous system in the spread of PrPSc. PMID:24828439

  10. Postdeposition annealing induced transition from hexagonal Pr{sub 2}O{sub 3} to cubic PrO{sub 2} films on Si(111)

    SciTech Connect

    Weisemoeller, T.; Bertram, F.; Gevers, S.; Greuling, A.; Deiter, C.; Tobergte, H.; Neumann, M.; Wollschlaeger, J.; Giussani, A.; Schroeder, T.

    2009-06-15

    Films of hexagonal praseodymium sesquioxide (h-Pr{sub 2}O{sub 3}) were deposited on Si(111) by molecular beam epitaxy and thereafter annealed in 1 atm oxygen at different temperatures, ranging from 100 to 700 deg. C. The films of the samples annealed at 300 deg. C or more were transformed to PrO{sub 2} with B-oriented Fm3m structure, while films annealed at lower temperatures kept the hexagonal structure. The films are composed of PrO{sub 2} and PrO{sub 2-d}elta species, which coexist laterally and are tetragonally distorted due to the interaction at the interface between oxide film and Si substrate. Compared to PrO{sub 2}, PrO{sub 2-d}elta has the same cubic structure but with oxygen vacancies. The oxygen vacancies are partly ordered and increase the vertical lattice constant of the film, whereas the lateral lattice constant is almost identical for both species and on all samples. The latter lattice constant matches the lattice constant of the originally crystallized hexagonal praseodymium sesquioxide. That means that no long range reordering of the praseodymium atoms takes place during the phase transformation.

  11. Salicylic acid induction-deficient mutants of Arabidopsis express PR-2 and PR-5 and accumulate high levels of camalexin after pathogen inoculation.

    PubMed Central

    Nawrath, C; Métraux, J P

    1999-01-01

    In Arabidopsis, systemic acquired resistance against pathogens has been associated with the accumulation of salicylic acid (SA) and the expression of the pathogenesis-related proteins PR-1, PR-2, and PR-5. We report here the isolation of two nonallelic mutants impaired in the pathway leading to SA biosynthesis. These SA induction-deficient (sid) mutants do not accumulate SA after pathogen inoculation and are more susceptible to both virulent and avirulent forms of Pseudomonas syringae and Peronospora parasitica. However, sid mutants are not as susceptible to these pathogens as are transgenic plants expressing the nahG gene encoding an SA hydroxylase that degrades SA to catechol. In contrast to NahG plants, only the expression of PR-1 is strongly reduced in sid mutants, whereas PR-2 and PR-5 are still expressed after pathogen attack. Furthermore, the accumulation of the phytoalexin camalexin is normal. These results indicate that SA-independent compensation pathways that do not operate in NahG plants are active in sid mutants. One of the mutants is allelic to eds5 (for enhanced disease susceptibility), whereas the other mutant has not been described previously. PMID:10449575

  12. [Aquatic animals of medical importance in Brazil].

    PubMed

    Haddad Junior, Vidal

    2003-01-01

    The injuries caused by venomous and poisonous aquatic animals may provoke important morbidity in the victim. The cnidarians (jellyfishes, especially cubomedusas and Portuguese-Man-of-War) caused nearly 25% of 236 accidents by marine animals, while sea urchins were responsible for about 50% and catfish, stingrays and scorpionfish nearly 25%). In freshwater, stingrays and catfish cause injuries with a very similar mechanism to the poisoning and the effects of the toxins of marine species. In a series of about 200 injuries observed among freshwater fishermen, nearly 40% were caused by freshwater catfish, 5% freshwater stingrays and 55% by traumatogenic fish, such as piranhas and traíras. The author presents the aquatic animals that cause injuries to humans in Brazil, the clinical aspects of the envenoming and the first measures for the control of the severe pain observed mainly in the accidents caused by cnidarians and venomous fishes.

  13. [National demonstration project on epilepsy in Brazil].

    PubMed

    Li, Li Min; Sander, J W A S

    2003-03-01

    Epilepsy is the most prevalent non-communicable serious neurological condition worldwide. Unfortunately, the majority of people with epilepsy in low-income countries do not receive appropriate treatment. Stigmatisation is the rule. In this setting, the World Health Organisation, the International League against Epilepsy and the International Bureau for Epilepsy launched the Global Campaign against Epilepsy in 1997. This entered its second phase in 2001 and as part of it has set up demonstration projects in the People's Republic of China, Zimbabwe, Senegal and, more recently, in Brazil. The objective of the demonstration projects is to show, through methodological evaluation, that it is possible to establish a model of treatment for people with epilepsy in primary health care settings. The Brazilian demonstration project has targeted regions in Campinas and S o Jose do Rio Preto, both in Sao Paulo State. A task force has been established to assess strategies to expand this project nationwide. PMID:12715043

  14. The challenges of ageism in Brazil

    PubMed Central

    Goldani, Ana Maria

    2013-01-01

    The material and symbolic resource flows and obligations between generations leave an indelible imprint on family members. These intergenerational exchanges have increased in recent years with growing human longevity and they thus have become important to current academic and policy agendas. Concurrently, ageism and age discrimination have emerged as important subjects. The main goal of this article is to call attention to these issues and their relationship with the current policy debate on resource allocation by age groups. We argue that ageism and the practice of age discrimination in Brazil should be viewed as part of the multiple forms of discrimination experienced by individuals. While noticing someone’s age is not inherently offensive, acting on age-based stereotypes clearly works against the individual and often goes unchallenged by mainstream society. A central assumption in this paper is that the way we frame ageism and intergenerational relations significantly affects perceived age discrimination and support for age-based social programs. PMID:26401063

  15. Literacy in Brazil: from Rights to Reality

    NASA Astrophysics Data System (ADS)

    Ireland, Timothy D.

    2008-11-01

    At a time when some 24% of the Brazilian population of 182 million are functionally illiterate, the author shows how illiteracy is concentrated in traditionally poor and disadvantaged social and ethnic groups as well as in certain regions of the country. He surveys the changes in legislation, policies and attitudes relating to literacy over the past few decades and describes how literacy is increasingly seen as a continuous process rather than a short-term, low-cost intervention. While there is still a lack of a broad, coordinated policy and adequate funding in this area, and while the challenges remain formidable, the author concludes that Brazil is moving slowly in the right direction.

  16. Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil

    PubMed Central

    Dumler, J. Stephen; Mafra, Cláudio Lísias; Calic, Simone Berger; Chamone, Chequer Buffe; Filho, Gracco Cesarino; Olano, Juan Pablo; Walker, David H.

    2003-01-01

    The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests. PMID:14718082

  17. [The anti-asylum movement in Brazil].

    PubMed

    Lüchmann, Lígia Helena Hahn; Rodrigues, Jefferson

    2007-01-01

    This study reviews the history of the national anti-asylum struggle in Brazil. It analyzes some of the movement's difficulties, achievements and challenges. The theory of social movements is used here as an important analytical tool to understand this collective action, to the degree in which theory allows an appraisal of this type of social action rooted in its many configurations, evidencing the complexity of the contemporary world. The anti-asylum movement is composed of many stakeholders whose struggles and conflicts have been developed through different social-political-institutional dimensions. It encompasses at different moments and to different degrees, a movement which articulates solidarity and conflict relations and social denunciations in an attempt to transform relations and conceptions that are discriminatory and which are intended to control the "insane" and "insanity" in our country.

  18. Flood forecasting for Tucurui Hydroelectrical Plant, Brazil

    SciTech Connect

    Solomon, S.I.; Basso, E.; Osorio, C.; Melo de Moraes, H.; Serrano, A.

    1986-04-01

    The construction of the Tucurui Hydroelectric Plant on the Tocantins River basin in Brazil requires flood forecasting to ensure the safety of the cofferdam. The latter has been initially designed for a flood with a return frequency of one in 25 years. Lack of adequate forecasting facilities during the earlier stages of construction has resulted in significant damages and construction delays. Statistical forecasting models were developed by Projeto de Hidrologia y Climatologie da Amazonia (PHCA) for the purpose of preventing further damage at the site. The application of these models during the 1980 flood season, when the highest flood on record occurred at the Tucurui site, proved of great assistance in preventing the flooding of the cofferdam. In conjunction with the development of these models a number of data collection platforms using data transmission through the GOES system were installed to provide the data required for forecasting.

  19. Current biomass energy technology in Brazil

    SciTech Connect

    Gibson, H.G.

    1985-06-01

    The potential for major biomass energy production in Brazil is very great because of the significant possibilities for expansion of the agricultural and forest production there. For example, production of 20 t/ha (metric) of dry wood in the Amazon basin is reported here by the senior author, who worked with the huge JARI operation there. In addition to the current large ethanol production (7.5 billion liters estimated 1983/84) based mainly on sugar cane, the potential for expanding this with sweet sorghum and cassava is promising. Research and development there and in the US resulted in a high-compression ethanol tractor showing slightly higher thermal efficiency than a standard diesel tractor under field operating conditions.

  20. Comments on human eurytremiasis in Brazil.

    PubMed

    Pinto, Hudson Alves; de Melo, Alan Lane

    2016-05-20

    Eurytremiasis is an important parasitic disease of cattle that was recently suggested to be a neglected and emerging human disease in Brazil. Based on a misinterpretation of the life cycle of the parasite, it was suggested that a great number of people could be infected with this fluke in the country. In the present letter, aspects of the life cycle of Eurytrema spp. are revisited and clarified. The mechanism of transmission previously reported for the few accidental human cases involved the ingestion of raw or undercooked insects (grasshoppers and crickets) harboring the infective metacercariae. In reality, the zoonotic potential of Eurytrema species is extremely low, and human eurytremiasis is not, and probably never will be, a zoonotic disease in countries where entomophagy is not a common food habit. PMID:27226956