Sample records for current basic research
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Basic science research in urology training.
Eberli, D; Atala, A
2009-04-01
The role of basic science exposure during urology training is a timely topic that is relevant to urologic health and to the training of new physician scientists. Today, researchers are needed for the advancement of this specialty, and involvement in basic research will foster understanding of basic scientific concepts and the development of critical thinking skills, which will, in turn, improve clinical performance. If research education is not included in urology training, future urologists may not be as likely to contribute to scientific discoveries.Currently, only a minority of urologists in training are currently exposed to significant research experience. In addition, the number of physician-scientists in urology has been decreasing over the last two decades, as fewer physicians are willing to undertake a career in academics and perform basic research. However, to ensure that the field of urology is driving forward and bringing novel techniques to patients, it is clear that more research-trained urologists are needed. In this article we will analyse the current status of basic research in urology training and discuss the importance of and obstacles to successful addition of research into the medical training curricula. Further, we will highlight different opportunities for trainees to obtain significant research exposure in urology.
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Focus on Basics: Connecting Research & Practice. Volume 7, Issue D
ERIC Educational Resources Information Center
Garner, Barbara, Ed.
2005-01-01
"Focus on Basics" is the quarterly publication of the National Center for the Study of Adult Learning and Literacy. It presents best practices, current research on adult learning and literacy, and how research is used by adult basic education teachers, counselors, program administrators, and policymakers. "Focus on Basics" is…
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Focus on Basics: Connecting Research & Practice. Volume 8, Issue B
ERIC Educational Resources Information Center
Garner, Barbara, Ed.
2006-01-01
"Focus on Basics" is the quarterly publication of the National Center for the Study of Adult Learning and Literacy. It presents best practices, current research on adult learning and literacy, and how research is used by adult basic education teachers, counselors, program administrators, and policymakers. "Focus on Basics" is…
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Focus on Basics: Connecting Research & Practice. Volume 6, Issue A
ERIC Educational Resources Information Center
Garner, Barbara, Ed.
2002-01-01
"Focus on Basics" is the quarterly publication of the National Center for the Study of Adult Learning and Literacy. It presents best practices, current research on adult learning and literacy, and how research is used by adult basic education teachers, counselors, program administrators, and policymakers. "Focus on Basics" is…
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Focus on Basics: Connecting Research & Practice. Volume 9, Issue B
ERIC Educational Resources Information Center
Garner, Barbara, Ed.
2008-01-01
"Focus on Basics" is a publication of the U.S. Division of World Education, Inc. It presents best practices, current research on adult learning and literacy, and how research is used by adult basic education teachers, counselors, program administrators, and policymakers. "Focus on Basics" is dedicated to connecting research…
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Focus on Basics: Connecting Research & Practice. Volume 6, Issue B
ERIC Educational Resources Information Center
Garner, Barbara, Ed.
2003-01-01
"Focus on Basics" is the quarterly publication of the National Center for the Study of Adult Learning and Literacy. It presents best practices, current research on adult learning and literacy, and how research is used by adult basic education teachers, counselors, program administrators, and policymakers. "Focus on Basics" is dedicated to…
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Focus on Basics: Connecting Research and Practice. Volume 6, Issue D
ERIC Educational Resources Information Center
National Center for the Study of Adult Learning and Literacy (NCSALL), Harvard University, 2004
2004-01-01
"Focus on Basics" is the quarterly publication of the National Center for the Study of Adult Learning and Literacy. It presents best practices, current research on adult learning and literacy, and how research is used by adult basic education teachers, counselors, program administrators, and policymakers. "Focus on Basics" is dedicated to…
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... Tips Info Center Research Topics Federal Policy Glossary Stem Cell Information General Information Clinical Trials Funding Information Current ... Basics » Stem Cell Basics I. Back to top Stem Cell Basics I. Introduction: What are stem cells, and ...
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[Platforms are needed for innovative basic research in ophthalmology].
Wang, Yi-qiang
2012-07-01
Basic research poses the cornerstone of technical innovation in all lines including medical sciences. Currently, there are shortages of professional scientists as well as technical supporting teams and facilities in the field of basic research of ophthalmology and visual science in China. Evaluation system and personnel policies are not supportive for innovative but high-risk-of-failure research projects. Discussion of reasons and possible solutions are given here to address these problems, aiming at promoting buildup of platforms hosting novel and important basic research in eye science in this country.
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Deckelbaum, Richard J; Ntambi, James M; Wolgemuth, Debra J
2011-09-01
This article provides evidence that basic science research and education should be key priorities for global health training, capacity building, and practice. Currently, there are tremendous gaps between strong science education and research in developed countries (the North) as compared to developing countries (the South). In addition, science research and education appear as low priorities in many developing countries. The need to stress basic science research beyond the typical investment of infectious disease basic service and research laboratories in developing areas is significant in terms of the benefits, not only to education, but also for economic strengthening and development of human resources. There are some indications that appreciation of basic science research education and training is increasing, but this still needs to be applied more rigorously and strengthened systematically in developing countries. Copyright © 2011 Elsevier Inc. All rights reserved.
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Toward an Implementation Paradigm of Educational Change.
ERIC Educational Resources Information Center
Berman, Paul
Besides identifying current problems in educational change research, this document describes the inadequate paradigm on which past research has been based and outlines a currently emerging paradigm of educational innovation. The author asserts that previous research findings have been inconsistent and not comparable. Basic to the research problems…
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Dyssynergia Cerebellaris Myoclonica
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Acute Disseminated Encephalomyelitis
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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ERIC Educational Resources Information Center
Matveeva, Natalia
2008-01-01
This research article reports the results of an online survey distributed among technical writing instructors in 2006. The survey aimed to examine how we teach intercultural communication in basic technical writing courses: our current practices and methods. The article discusses three major challenges that instructors may face when teaching about…
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The Politics of Time and Space in Japanese Adult Basic Education
ERIC Educational Resources Information Center
Jacobson, Erik
2015-01-01
This qualitative study examines critical pedagogy in Japanese adult basic education. The research focuses on what teachers and others think the current conditions are for education that deals with social justice. As part of this, the research looks at how critical pedagogy is conceptualized in this context. Participants in the study (literacy…
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Neurological Sequelae of Lupus
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Attention Deficit-Hyperactivity Disorder
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Aicardi-Goutieres Syndrome Disorder
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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,
1981-01-01
Research in the WRD had its beginnings in the late 1950's when the "core research" line item was added to the Congressional budget. Since this time the Federal program has grown from a "basic sciences" program to one that includes a broad spectrum of basic and applied scientific investigations. Water resources research in WRD includes the study of water in all its phases and uses the basic sciences of mathematics, chemistry, physics, biology, geology and engineering to gain a fundamental understanding of the processes that affect the movement of water and its chemical constituents through hydrologic systems. The basic knowledge and methodologies derived from water resources research are applicable not only to the solution of current problems associated with the Nation's water resources, but also to anticipated hydrologic issues.
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... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Questions and Answers about Stroke
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Questions and Answers about Carotid Endarterectomy
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Neurological Complications of Lyme Disease
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Deep Brain Stimulation for Parkinson's Disease
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Ataxias and Cerebellar or Spinocerebellar Degeneration
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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The State of Space Propulsion Research
NASA Technical Reports Server (NTRS)
Sackheim, R. L.; Cole, J. W.; Litchford, R. J.
2006-01-01
The current state of space propulsion research is assessed from both a historical perspective, spanning the decades since Apollo, and a forward-looking perspective, as defined by the enabling technologies required for a meaningful and sustainable human and robotic exploration program over the forthcoming decades. Previous research and technology investment approaches are examined and a course of action suggested for obtaining a more balanced portfolio of basic and applied research. The central recommendation is the establishment of a robust national Space Propulsion Research Initiative that would run parallel with systems development and include basic research activities. The basic framework and technical approach for this proposed initiative are defined and a potential implementation approach is recommended.
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Back to the Future: Implications of the Neopositivist Research Agenda for Adult Basic Education
ERIC Educational Resources Information Center
Belzer, Alisa; Clair, Ralf St.
2005-01-01
Federal educational policy, funding, and legislation are currently forwarding a research agenda described by the current administration as scientifically based. We characterize this agenda, described in multiple official documents as the gold standard, as neopositivist. We consider the ways in which this research paradigm and the methods that…
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Multiple System Atrophy with Orthostatic Hypotension (Shy-Drager Syndrome)
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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NIH Scientists Try to Crack the Brain's Memory Codes
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Scientists Take a Close-Up of Key Pain-Sensing Molecule
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Questions and Answers about Treating Arterial Stenosis and Preventing Stroke
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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SUNCT Headache (Short-Lasting, Unilateral, Neuralgiform with Conjunctival Injection and Tearing)
... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...
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Schultze-Lutter, F
2016-12-01
The early detection of psychoses has become increasingly relevant in research and clinic. Next to the ultra-high risk (UHR) approach that targets an immediate risk of developing frank psychosis, the basic symptom approach that targets the earliest possible detection of the developing disorder is being increasingly used worldwide. The present review gives an introduction to the development and basic assumptions of the basic symptom concept, summarizes the results of studies on the specificity of basic symptoms for psychoses in different age groups as well as on studies of their psychosis-predictive value, and gives an outlook on future results. Moreover, a brief introduction to first recent imaging studies is given that supports one of the main assumptions of the basic symptom concept, i. e., that basic symptoms are the most immediate phenomenological expression of the cerebral aberrations underlying the development of psychosis. From this, it is concluded that basic symptoms might be able to provide important information on future neurobiological research on the etiopathology of psychoses. © Georg Thieme Verlag KG Stuttgart · New York.
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ERIC Educational Resources Information Center
Pennsylvania State Univ., University Park. Inst. for the Study of Adult Literacy.
The goal of this research project was to create a guide on the effective use of assessment instruments and methodologies, related resources, and guidelines for measuring adult learners' attainment of basic skills and competencies to document educational gains and demonstrate program quality. The project focused on confirming current use of…
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Wallner, Paul E., E-mail: pwallner@theabr.org; Anscher, Mitchell S.; Barker, Christopher A.
In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective ofmore » relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report.« less
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Wallner, Paul E; Anscher, Mitchell S; Barker, Christopher A; Bassetti, Michael; Bristow, Robert G; Cha, Yong I; Dicker, Adam P; Formenti, Silvia C; Graves, Edward E; Hahn, Stephen M; Hei, Tom K; Kimmelman, Alec C; Kirsch, David G; Kozak, Kevin R; Lawrence, Theodore S; Marples, Brian; McBride, William H; Mikkelsen, Ross B; Park, Catherine C; Weidhaas, Joanne B; Zietman, Anthony L; Steinberg, Michael
2014-01-01
In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective of relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report. Copyright © 2014 Elsevier Inc. All rights reserved.
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Lau, Dennis H; Volders, Paul G A; Kohl, Peter; Prinzen, Frits W; Zaza, Antonio; Kääb, Stefan; Oto, Ali; Schotten, Ulrich
2015-05-01
Cardiac electrophysiology has evolved into an important subspecialty in cardiovascular medicine. This is in part due to the significant advances made in our understanding and treatment of heart rhythm disorders following more than a century of scientific discoveries and research. More recently, the rapid development of technology in cellular electrophysiology, molecular biology, genetics, computer modelling, and imaging have led to the exponential growth of knowledge in basic cardiac electrophysiology. The paradigm of evidence-based medicine has led to a more comprehensive decision-making process and most likely to improved outcomes in many patients. However, implementing relevant basic research knowledge in a system of evidence-based medicine appears to be challenging. Furthermore, the current economic climate and the restricted nature of research funding call for improved efficiency of translation from basic discoveries to healthcare delivery. Here, we aim to (i) appraise the broad challenges of translational research in cardiac electrophysiology, (ii) highlight the need for improved strategies in the training of translational electrophysiologists, and (iii) discuss steps towards building a favourable translational research environment and culture. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.
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NASA Technical Reports Server (NTRS)
LaBel, Kenneth A.; Sampson, Michael J.
2016-01-01
This presentation will provide basic information about NASA's Electronic Parts and Packaging Program (NEPP), for sharing with representatives of the South Korean Aerospace Research Institute (KARI) as part of a larger presentation by Headquarters Office of Safety and Mission Assurance. The NEPP information includes mission and goals, history of the program, basic focus areas, strategies, deliverables and some examples of current tasks.
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ERIC Educational Resources Information Center
Pearson, P. David, Ed.; And Others
Intended for reading educators and researchers, this handbook characterizes the current state of methodology and the cumulative research-based knowledge of reading. The book's three sections cover methodological issues, basic reading processes, and instructional practices. The 25 chapters discuss the following topics: (1) reading research history,…
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Current Status and Issues in Basic Pharmaceutical Education.
Yasuhara, Tomohisa
2017-01-01
Basic research in pharmaceutical sciences has a long and successful history. Researchers in this field have long given prime importance to the knowledge they have gained through their pharmaceutical education. The transition of pharmacy education to a 6-year course term has not only extended its duration but also placed more emphasis on practical clinical education. The School Education Act (in article 87, second paragraph) determines that "the term of the course, whose main purpose is to cultivate practical ability in clinical pharmacy, shall be six years" (excerpt). The 6-year pharmacy education is an exception to the general 4-year university term determined by the School Education Act. Therefore, the purpose of the 6-year course in pharmacy is clearly proscribed. This is true of the basic course in pharmaceutical education as well; hence, the basic course must be oriented toward developing "practical ability in clinical" education, too. The 6-year pharmacy course, starting from practice (Do), has evolved with the development of a syllabus that includes a model core curriculum (Plan). Furthermore, improvement in the course can be seen by the promoted development of faculty (Act). Now, evidence-based education research will be introduced (Check). This is how the Plan-Do-Check-Act cycle in pharmaceutical education is expected to work. Currently, pedagogy research in pharmacy education has just begun, so it is difficult to evaluate at this time whether basic pharmaceutical education does in fact contribute to enhancing the "practical clinical ability" component of pharmaceutical education.
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78 FR 1266 - Notice of Intent To Seek Approval To Extend a Current Information Collection
Federal Register 2010, 2011, 2012, 2013, 2014
2013-01-08
... (salaries, indirect costs, equipment, etc.), and character of work (basic research, applied research, or.... SUPPLEMENTARY INFORMATION: Title of Collection: Higher Education Research and Development Survey. OMB Control... Project: The Higher Education Research and Development Survey (formerly known as the Survey of Research...
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Current, Short Term, Future and Star Wars Research Projects for Ornamental Crops
USDA-ARS?s Scientific Manuscript database
The USDA-ARS Greenhouse Production Research Group is involved in fundamental and developmental plant research aimed at developing tools for early stress detection and efficient agrochemical utilization for protected horticulture crops. The group conducts basic plant biology research with the goal o...
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Fundamental heat transfer research for gas turbine engines
NASA Technical Reports Server (NTRS)
Metzger, D. E. (Editor)
1980-01-01
Thirty-seven experts from industry and the universities joined 24 NASA Lewis staff members in an exchange of ideas on trends in aeropropulsion research and technology, basic analyses, computational analyses, basic experiments, near-engine environment experiments, fundamental fluid mechanics and heat transfer, and hot technology as related to gas turbine engines. The workshop proceedings described include pre-workshop input from participants, presentations of current activity by the Lewis staff, reports of the four working groups, and a workshop summary.
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Students' Conceptions of Function Transformation in a Dynamic Mathematical Environment
ERIC Educational Resources Information Center
Daher, Wajeeh; Anabousy, Ahlam
2015-01-01
The study of function transformations helps students understand the function concept which is a basic and main concept in mathematics, but this study is problematic to school students as well as college students, especially when transformations are performed on non-basic functions. The current research tried to facilitate grade 9 students'…
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Language Management Theory as One Approach in Language Policy and Planning
ERIC Educational Resources Information Center
Nekvapil, Jirí
2016-01-01
Language Policy and Planning is currently a significantly diversified research area and thus it is not easy to find common denominators that help to define basic approaches within it. Richard B. Baldauf attempted to do so by differentiating between four basic approaches: (1) the classical approach, (2) the language management approach (Language…
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The future of research in female pelvic medicine.
Chao, Jamie; Chai, Toby C
2015-02-01
Female pelvic medicine and reconstructive surgery (FPMRS) was recently recognized as a subspecialty by the American Board of Medical Specialties (ABMS). FPMRS treats female pelvic disorders (FPD) including pelvic organ prolapse (POP), urinary incontinence (UI), fecal incontinence (FI), lower urinary tract symptoms (LUTS), lower urinary tract infections (UTI), pelvic pain, and female sexual dysfunction (FSD). These conditions affect large numbers of individuals, resulting in significant patient, societal, medical, and financial burdens. Given that treatments utilize both medical and surgical approaches, areas of research in FPD necessarily cover a gamut of topics, ranging from mechanistically driven basic science research to randomized controlled trials. While basic science research is slow to impact clinical care, transformational changes in a field occur through basic investigations. On the other hand, clinical research yields incremental changes to clinical care. Basic research intends to change understanding whereas clinical research intends to change practice. However, the best approach is to incorporate both basic and clinical research into a translational program which makes new discoveries and effects positive changes to clinical practice. This review examines current research in FPD, with focus on translational potential, and ponders the future of FPD research. With a goal of improving the care and outcomes in patients with FPD, a strategic collaboration of stakeholders (patients, advocacy groups, physicians, researchers, professional medical associations, legislators, governmental biomedical research agencies, pharmaceutical companies, and medical device companies) is an absolute requirement in order to generate funding needed for FPD translational research.
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USDA-ARS?s Scientific Manuscript database
The Agricultural Research Service (ARS) is the intramural research agency of the United States Department of Agriculture (USDA) which employs scientists to conduct basic and applied research aimed to develop and transfer solutions to agricultural problems of high national priority and to ensure food...
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Geographical and temporal distribution of basic research experiments in homeopathy.
Clausen, Jürgen; van Wijk, Roeland; Albrecht, Henning
2014-07-01
The database HomBRex (Homeopathy Basic Research experiments) was established in 2002 to provide an overview of the basic research already done on homeopathy (http://www.carstens-stiftung.de/hombrex). By this means, it facilitates the exploration of the Similia Principle and the working mechanism of homeopathy. Since 2002, the total number of experiments listed has almost doubled. The current review reports the history of basic research in homeopathy as evidenced by publication dates and origin of publications. In July 2013, the database held 1868 entries. Most publications were reported from France (n = 267), followed by Germany (n = 246) and India (n = 237). In the last ten years, the number of publications from Brazil dramatically increased from n = 13 (before 2004) to n = 164 (compared to n = 251 published in France before 2004, and n = 16 between 2004 and 2013). The oldest database entry was from Germany (1832). Copyright © 2014 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.
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Chaos Modeling: An Introduction and Research Application.
ERIC Educational Resources Information Center
Newman, Isadore; And Others
1993-01-01
Introduces the basic concepts of chaos theory and chaos modeling. Relates chaos theory to qualitative research and factor analysis. Describes some current research in education and psychology using chaos theory. Claims that the philosophical implications of chaos theory have been misapplied in practical terms. (KS)
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Future vaccination strategies against tuberculosis: thinking outside the box.
Kaufmann, Stefan H E
2010-10-29
With almost a dozen vaccine candidates in clinical trials, tuberculosis (TB) research and development is finally reaping the first fruits of its labors. Vaccine candidates in clinical trials may prevent TB disease reactivation by efficiently containing the pathogen Mycobacterium tuberculosis (Mtb). Future research should target vaccines that achieve sterile eradication of Mtb or even prevent stable infection. These are ambitious goals that can be reached only by highly cooperative engagement of basic immunologists, vaccinologists, and clinical researchers--or in other words, by translation from basic immunology to vaccine research and development, as well as reverse translation of insights from clinical trials back to hypothesis-driven research in the basic laboratory. Here, we review current and future strategies toward the rational design of novel vaccines against TB, as well as the progress made thus far, and the hurdles that need to be overcome in the near and distant future. Copyright © 2010 Elsevier Inc. All rights reserved.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Miller, W.
MRI has excellent soft tissue contrast and can provide both anatomical and physiological information. It is becoming increasingly important in radiation therapy for treatment planning, image-guided radiation therapy, and treatment assessment. It is critically important at this time point to educate and update our medical physicists about MRI to prepare for the upcoming surge of MRI applications in radiation therapy. This session will review important basics of MR physics, pulse sequence designs, and current radiotherapy application, as well as showcase exciting new developments in MRI that can be potentially useful in radiation therapy. Learning Objectives: To learn basics of MRmore » physics and understand the differences between various pulse sequences To review current applications of MRI in radiation therapy.To discuss recent MRI advances for future MRI guided radiation therapy Partly supported by NIH (1R21CA165384).; W. Miller, Research supported in part by Siemens Healthcare; G. Li, My clinical research is in part supported by NIH U54CA137788. I have a collaborative research project with Philips Healthcare.; J. Cai, jing cai.« less
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Liu, Ye; Liu, Dan
2015-07-01
Urban metabolism is a basic theory for coping with global environmental problems, which is coherent with the aims of national environmental management. This paper analyzed the concept of urban metabolism, and pointed out the meaning for urban metabolism in physical space entities; reviewed the current methods for urban metabolism and its merits and shortages; analyzed the system boundaries, connotation, and methodologies; and summarized the advances on urban meta-bolism practices in physical space entities. At last, we made conclusions that there were shortages, including conception system, basic theory system, and interdisciplinary integrated theory system in current urban metabolism research, and the current cases studied in urban metabolism were limited and not suitable to the harmony development between society, economy, and environment. In the future, we need to strengthen comparison between different case studies from different countries, develop the prior modes of typical urban metabolism research, identify the mechanism for urban ecosystem, and strengthen the spatial decision support system of environmental management taking urban spatial entity spaces as units.
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Qualitative Research in Counseling Psychology: Conceptual Foundations
ERIC Educational Resources Information Center
Morrow, Susan L.
2007-01-01
Beginning with calls for methodological diversity in counseling psychology, this article addresses the history and current state of qualitative research in counseling psychology. It identifies the historical and disciplinary origins as well as basic assumptions and underpinnings of qualitative research in general, as well as within counseling…
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1991-06-01
The report represents responses by agencies of DHHS, and by DOE and EPA, to requests by the Director of NTP for information on agency programs in basic toxicology research, toxicology testing, and toxicology methods development. Information on dollar and manpower support for agency activities in basic toxicology research, toxicology testing, and toxicology methods development, by DHHS, DOE and EPA, is summarized on pages 4 to 10. All agencies were requested to provide summary information on their programs related to toxicology methods development, whether essential or peripheral to their missions. The information provided in response to the request is summarized inmore » tables on pages 48 to 81. Information was provided on chemical compounds currently being studied for their toxicological properties in intramural laboratories, or on contracts, or through grants.« less
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Five Critical Practices for Middle Grades Leadership: A Framework for School Improvement
ERIC Educational Resources Information Center
Nash, Ruth C.; Richardson, Yvette M.; Hodge, Patricia H.; Connell, Peggy H.; Green, Zebbra P.
2014-01-01
Based on current research, many students in the middle grades (6-8) have not performed at their highest academic levels. In 2011, more than one-half of eighth graders in 16 Southern states scored basic or below basic on the National Assessment of Educational Progress (NAEP). Alternatively, effective principal-leaders strategically demonstrated…
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A Multicomponent Measure of Writing Motivation with Basic College Writers
ERIC Educational Resources Information Center
MacArthur, Charles A.; Philippakos, Zoi A.; Graham, Steve
2016-01-01
The purpose of the current study was to develop and validate a measure of motivation for use with basic college writers that would measure self-efficacy, achievement goals, beliefs, and affect. As part of a design research project on curriculum for community college developmental writing classes, 133 students in 11 classes completed the motivation…
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Recent Brain Research on Young Children.
ERIC Educational Resources Information Center
Flohr, John W.
1999-01-01
Provides information about current brain research. Explains that some of the basic tenets that have guided research are outlined in R. Shore's "Rethinking the Brain: New Insights into Early Development." Offers five hypotheses: (1) nature/nurture; (2) effects of nurture; (3) optimal music learning; (4) minimal disadvantages; and (5) early music…
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[The current clinical laboratory in the public health system and medical science: a lecture].
Men'shikov, V V
2011-11-01
The analytic and diagnostic possibilities of current clinical laboratories are discussed. The roles of laboratory information in the formation of new research directions are characterized. The proposals on the development of economic basics of the development of laboratory medicine.
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A review of second law techniques applicable to basic thermal science research
NASA Astrophysics Data System (ADS)
Drost, M. Kevin; Zamorski, Joseph R.
1988-11-01
This paper reports the results of a review of second law analysis techniques which can contribute to basic research in the thermal sciences. The review demonstrated that second law analysis has a role in basic thermal science research. Unlike traditional techniques, second law analysis accurately identifies the sources and location of thermodynamic losses. This allows the development of innovative solutions to thermal science problems by directing research to the key technical issues. Two classes of second law techniques were identified as being particularly useful. First, system and component investigations can provide information of the source and nature of irreversibilities on a macroscopic scale. This information will help to identify new research topics and will support the evaluation of current research efforts. Second, the differential approach can provide information on the causes and spatial and temporal distribution of local irreversibilities. This information enhances the understanding of fluid mechanics, thermodynamics, and heat and mass transfer, and may suggest innovative methods for reducing irreversibilities.
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Heinen, Christopher D
2016-02-01
We have currently entered a genomic era of cancer research which may soon lead to a genomic era of cancer treatment. Patient DNA sequencing information may lead to a personalized approach to managing an individual's cancer as well as future cancer risk. The success of this approach, however, begins not necessarily in the clinician's office, but rather at the laboratory bench of the basic scientist. The basic scientist plays a critical role since the DNA sequencing information is of limited use unless one knows the function of the gene that is altered and the manner by which a sequence alteration affects that function. The role of basic science research in aiding the clinical management of a disease is perhaps best exemplified by considering the case of Lynch syndrome, a hereditary disease that predisposes patients to colorectal and other cancers. This review will examine how the diagnosis, treatment and even prevention of Lynch syndrome-associated cancers has benefitted from extensive basic science research on the DNA mismatch repair genes whose alteration underlies this condition. Copyright © 2015 Elsevier B.V. All rights reserved.
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Artificial Intelligence: Underlying Assumptions and Basic Objectives.
ERIC Educational Resources Information Center
Cercone, Nick; McCalla, Gordon
1984-01-01
Presents perspectives on methodological assumptions underlying research efforts in artificial intelligence (AI) and charts activities, motivations, methods, and current status of research in each of the major AI subareas: natural language understanding; computer vision; expert systems; search, problem solving, planning; theorem proving and logic…
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This is a presentation on the basics of green roof technology. The presentation highlights some of the recent ORD research projects on green roofs and provices insight for the end user as to the benefits for green roof technology. It provides links to currently available EPA re...
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The Current Status of School Counseling Outcome Research. Research Monograph, Number 2
ERIC Educational Resources Information Center
McGannon, Wendy; Carey, John; Dimmitt, Carey
2005-01-01
This paper will review some of the issues in school counseling outcome research and how these issues relate to the No Child Left Behind (NCLB) Legislation. Some basic information related to the NCLB mandates will be reviewed in terms of how they impact the school counseling profession and counselor accountability. Types of research will be…
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ERIC Educational Resources Information Center
Mahmoudi, Hojjat; Brown, Monica R.; Amani Saribagloo, Javad; Dadashzadeh, Shiva
2018-01-01
This aim of this current research was a multi-level analysis of the relationship between school culture, basic psychological needs, and adolescents' academic alienation. One thousand twenty-nine (N = 1,029) high school students from Qom City were randomly selected through a multi-phase cluster sampling method and answered questions regarding…
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ERIC Educational Resources Information Center
Al-Kindi, Naeema Saleh; AL-Mekhlafi, Abdo Mohammed
2017-01-01
The purpose of the current study is to investigate post-basic English teachers' practice of critical thinking skills and the challenges they face while teaching skills in EFL classrooms. Three research questions were investigated to achieve this purpose: 1--To what extent do EFL teachers use classroom behaviors that nurture critical thinking at…
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ERIC Educational Resources Information Center
Ministerio de Educacion Nacional, Bogota (Colombia). Instituto Colombiano de Pedagogia.
This booklet defines and establishes guidelines for educational research in Colombia. Sections describe basic philosophy and objectives, types of research, policies for educational investigation, governmental role, and principle areas for educational research. A listing of current and proposed research projects is provided. The final section…
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Methodologies in Creating Skin Substitutes
Nicholas, Mathew N; Jeschke, Marc G; Amini-Nik, Saeid
2016-01-01
The creation of skin substitutes has significantly decreased morbidity and mortality of skin wounds. Although there are still a number of disadvantages of currently available skin substitutes, there has been a significant decline in research advances over the past several years in improving these skin substitutes. Clinically most skin substitutes used are acellular and do not use growth factors to assist wound healing, key areas of potential in this field of research. This article discusses the five necessary attributes of an ideal skin substitute. It comprehensively discusses the three major basic components of currently available skin substitutes: scaffold materials, growth factors, and cells, comparing and contrasting what has been used so far. It then examines a variety of techniques in how to incorporate these basic components together to act as a guide for further research in the field to create cellular skin substitutes with clinically better results. PMID:27154041
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Arctic research in the classroom: A teacher's experiences translated into data driven lesson plans
NASA Astrophysics Data System (ADS)
Kendrick, E. O.; Deegan, L.
2011-12-01
Incorporating research into high school science classrooms can promote critical thinking skills and provide a link between students and the scientific community. Basic science concepts become more relevant to students when taught in the context of research. A vital component of incorporating current research into classroom lessons is involving high school teachers in authentic research. The National Science Foundation sponsored Research Experience for Teachers (RET) program has inspired me to bring research to my classroom, communicate the importance of research in the classroom to other teachers and create lasting connections between students and the research community. Through my experiences as an RET at Toolik Field Station in Alaska, I have created several hands-on lessons and laboratory activities that are based on current arctic research and climate change. Each lesson uses arctic research as a theme for exemplifying basic biology concepts as well as increasing awareness of current topics such as climate change. For instance, data collected on the Kuparuk River will be incorporated into classroom activities that teach concepts such as primary production, trophic levels in a food chain and nutrient cycling within an ecosystem. Students will not only understand the biological concepts but also recognize the ecological implications of the research being conducted in the arctic. By using my experience in arctic research as a template, my students will gain a deeper understanding of the scientific process. I hope to create a crucial link of information between the science community and science education in public schools.
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Ebner, Susanne; Fabritius, Cornelia; Ritschl, Paul; Oberhuber, Rupert; Günther, Julia; Kotsch, Katja
2014-10-01
A joint meeting organized by the European (ESOT) and The Transplantation (TTS) Societies for basic science research was organized in Paris, France, on November 7-9, 2013. Focused on new ideas and concepts in translational transplantation, the meeting served as a venue for state-of-the-art developments in basic transplantation immunology, such as the potential for tolerance induction through regulation of T-cell signaling. This meeting report summarizes important insights which were presented in Paris. It not only offers an overview of established aspects, such as the role of Tregs in transplantation, presented by Nobel laureate Rolf Zinkernagel, but also highlights novel facets in the field of transplantation, that is cell-therapy-based immunosuppression or composite tissue transplantation as presented by the emotional story given by Vasyly Rohovyy, who received two hand transplants. The ESOT/TTS joint meeting was an overall productive and enjoyable platform for basic science research in translational transplantation and fulfilled all expectations by giving a promising outlook for the future of research in the field of immunological transplantation research. © 2014 Steunstichting ESOT.
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Enhancing Education for Deaf Children: Research into Practice and Back Again
ERIC Educational Resources Information Center
Swanwick, Ruth; Marschark, Marc
2010-01-01
Decades of research on educational and basic scientific questions relating to deaf children have yielded a wealth of knowledge about how they learn and develop as thinking, social, problem-solving individuals. However, we currently lack channels for communication from teachers to researchers about the priorities in education and from researchers…
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Setting FIRES to Stem Cell Research
ERIC Educational Resources Information Center
Miller, Roxanne Grietz
2005-01-01
The goal of this lesson is to present the basic scientific knowledge about stem cells, the promise of stem cell research to medicine, and the ethical considerations and arguments involved. One of the challenges of discussing stem cell research is that the field is constantly evolving and the most current information changes almost daily. Few…
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[Results from biomedical aging research. Trends and current examples from immunology].
Pfister, G; Herndler-Brandstetter, D; Grubeck-Loebenstein, B
2006-06-01
The public health of our society is challenged by a continuous increase in life expectancy. Hence, biomedical aging research is enjoying a steadily increasing popularity but also enlightens our understanding of age-related diseases by a number of striking results from basic research. One of the most striking changes that occurs during normal human aging is an overall diminution of immune functions, a phenomenon often termed immunosenescence. Starting from some highly exciting examples from basic immunological research, this article sheds light on which impact normal human aging has on several immune defence mechanisms. In addition, clinical consequences in view of Alzheimer's disease, immunogenicity of vaccines and autoimmune diseases are discussed.
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Ma, Bin; Xu, Jia-Ke; Wu, Wen-Jing; Liu, Hong-Yan; Kou, Cheng-Kun; Liu, Na; Zhao, Lulu
2017-01-01
To investigate the awareness and use of the Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE) risk-of-bias tool, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) reporting guidelines, and Gold Standard Publication Checklist (GSPC) in China in basic medical researchers of animal experimental studies. A national questionnaire-based survey targeting basic medical researchers was carried in China to investigate the basic information and awareness of SYRCLE's risk of bias tool, ARRIVE guidelines, GSPC, and animal experimental bias risk control factors. The EpiData3.1 software was used for data entry, and Microsoft Excel 2013 was used for statistical analysis in this study. The number of cases (n) and percentage (%) of classified information were statistically described, and the comparison between groups (i.e., current students vs. research staff) was performed using chi-square test. A total of 298 questionnaires were distributed, and 272 responses were received, which included 266 valid questionnaires (from 118 current students and 148 research staff). Among the 266 survey participants, only 15.8% was aware of the SYRCLE's risk of bias tool, with significant difference between the two groups (P = 0.003), and the awareness rates of ARRIVE guidelines and GSPC were only 9.4% and 9.0%, respectively; 58.6% survey participants believed that the reports of animal experimental studies in Chinese literature were inadequate, with significant difference between the two groups (P = 0.004). In addition, only approximately 1/3 of the survey participants had read systematic reviews and meta-analysis reports of animal experimental studies; only 16/266 (6.0%) had carried out/participated in and 11/266 (4.1%) had published systematic reviews/meta-analysis of animal experimental studies. The awareness and use rates of SYRCLE's risk-of-bias tool, the ARRIVE guidelines, and the GSPC were low among Chinese basic medical researchers. Therefore, specific measures are necessary to promote and popularize these standards and specifications and to introduce these standards into guidelines of Chinese domestic journals as soon as possible to raise awareness and increase use rates of researchers and journal editors, thereby improving the quality of animal experimental methods and reports.
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ERIC Educational Resources Information Center
Focus on Basics, 1999
1999-01-01
This volume consists of four issues that present best practices, current research on adult learning and literacy, and how research is used. Issue 1(A) on adult multiple intelligences has seven articles: "MI (Multiple Intelligences), the GED (General Educational Development), and Me (Martha Jean); "Understanding Multiple Intelligences: The Theory…
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Emerging Drugs for the Treatment of Anxiety
Murrough, James W.; Yaqubi, Sahab; Sayed, Sehrish; Charney, Dennis S.
2016-01-01
Introduction Anxiety disorders are among the most prevalent and disabling psychiatric disorders in the United States and worldwide. Basic research has provided critical insights into the mechanism regulating fear behavior in animals and a host of animal models have been developed in order to screen compounds for anxiolytic properties. Despite this progress, no mechanistically novel agents for the treatment of anxiety have come to market in more than two decades. Areas covered The current review will provide a critical summary of current pharmacological approaches to the treatment of anxiety and will examine the pharmacotherapeutic pipeline for treatments in development. Anxiety and related disorders considered herein include panic disorder, social anxiety disorder, generalized anxiety disorder and posttraumatic stress disorder. The glutamate, neuropeptide and endocannabinoid systems show particular promise as future targets for novel drug development. Expert opinion In the face of an ever-growing understanding of fear related behavior, the field awaits the translation of this research into mechanistically novel treatments. Obstacles will be overcome through close collaboration between basic and clinical researchers with the goal of aligning valid endophenotypes of human anxiety disorders with improved animal models. Novel approaches are needed to move basic discoveries into new, more effective treatments for our patients. PMID:26012843
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Ethical Decision Making: What Is Currently the Case?
ERIC Educational Resources Information Center
Welfel, Elizabeth Reynolds; Lipsitz, Neal E.
This paper reviews the current empirical literature on counselor ethics, suggesting that it offers little guidance in understanding why unethical behavior occurs or how to remedy such behavior. The research literature is classified according to four basic areas of concern: (1) documenting the incidence of unethical practice; (2) identifying the…
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Current Evolutionary Perspectives on Adolescent Romantic Relations and Sexuality
ERIC Educational Resources Information Center
Weisfeld, Glenn E.; Woodward, Laura
2004-01-01
This article describes current evolutionary research on adolescent sexual and romantic behavior. It first reviews functional explanations for basic sex differences in behavior. As in other pair-bonding mammals, women seek dominant males, and men seek and guard young, fertile females. Recent work is then described on adolescent competitiveness,…
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Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment.
Forgeard, Marie J C; Haigh, Emily A P; Beck, Aaron T; Davidson, Richard J; Henn, Fritz A; Maier, Steven F; Mayberg, Helen S; Seligman, Martin E P
2011-12-01
Despite decades of research on the etiology and treatment of depression, a significant proportion of the population is affected by the disorder, fails to respond to treatment and is plagued by relapse. Six prominent scientists, Aaron Beck, Richard Davidson, Fritz Henn, Steven Maier, Helen Mayberg, and Martin Seligman, gathered to discuss the current state of scientific knowledge on depression, and in particular on the basic neurobiological and psychopathological processes at play in the disorder. These general themes were addressed: 1) the relevance of learned helplessness as a basic process involved in the development of depression; 2) the limitations of our current taxonomy of psychological disorders; 3) the need to work towards a psychobiological process-based taxonomy; and 4) the clinical implications of implementing such a process-based taxonomy.
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Beyond Depression: Towards a Process-Based Approach to Research, Diagnosis, and Treatment
Forgeard, Marie J. C.; Haigh, Emily A. P.; Beck, Aaron T.; Davidson, Richard J.; Henn, Fritz A.; Maier, Steven F.; Mayberg, Helen S.; Seligman, Martin E. P.
2012-01-01
Despite decades of research on the etiology and treatment of depression, a significant proportion of the population is affected by the disorder, fails to respond to treatment and is plagued by relapse. Six prominent scientists, Aaron Beck, Richard Davidson, Fritz Henn, Steven Maier, Helen Mayberg, and Martin Seligman, gathered to discuss the current state of scientific knowledge on depression, and in particular on the basic neurobiological and psychopathological processes at play in the disorder. These general themes were addressed: 1) the relevance of learned helplessness as a basic process involved in the development of depression; 2) the limitations of our current taxonomy of psychological disorders; 3) the need to work towards a psychobiological process-based taxonomy; and 4) the clinical implications of implementing such a process-based taxonomy. PMID:22509072
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TH-F-202-02: Current Applications of MRI in Radiotherapy
DOE Office of Scientific and Technical Information (OSTI.GOV)
Li, G.
MRI has excellent soft tissue contrast and can provide both anatomical and physiological information. It is becoming increasingly important in radiation therapy for treatment planning, image-guided radiation therapy, and treatment assessment. It is critically important at this time point to educate and update our medical physicists about MRI to prepare for the upcoming surge of MRI applications in radiation therapy. This session will review important basics of MR physics, pulse sequence designs, and current radiotherapy application, as well as showcase exciting new developments in MRI that can be potentially useful in radiation therapy. Learning Objectives: To learn basics of MRmore » physics and understand the differences between various pulse sequences To review current applications of MRI in radiation therapy.To discuss recent MRI advances for future MRI guided radiation therapy Partly supported by NIH (1R21CA165384).; W. Miller, Research supported in part by Siemens Healthcare; G. Li, My clinical research is in part supported by NIH U54CA137788. I have a collaborative research project with Philips Healthcare.; J. Cai, jing cai.« less
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Back to the Basics: Cnidarians Start to Fire
Bosch, Thomas C. G.; Klimovich, Alexander; Domazet-Lošo, Tomislav; Gründer, Stefan; Holstein, Thomas W.; Jékely, Gáspár; Miller, David J.; Murillo-Rincon, Andrea P.; Rentzsch, Fabian; Richards, Gemma S.; Schröder, Katja; Technau, Ulrich; Yuste, Rafael
2016-01-01
The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to inform us about basic structural and functional principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of some cnidarian species and propose that researchers should seize this opportunity and undertake the study of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience. PMID:28041633
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ERIC Educational Resources Information Center
Sengul, Ozge Aydin
2016-01-01
The purpose of the current study is to investigate the pre-service teachers' opinions about science within the context of the basic elements of the education program, such as objectives, content, learning-teaching process and evaluation. The study was designed as a case study, one of the qualitative research methods. The participants of the study…
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Effective Schools: Do Elementary Prescriptions Fit Secondary Schools?
ERIC Educational Resources Information Center
Firestone, William A.; Herriott, Robert E.
Most of the recent research identifying organizational characteristics that seem to make schools unusually effective has been conducted at the elementary level and may not be applicable to secondary schools. Research currently underway suggests that the basic organizational structures of elementary and secondary schools dictate two different…
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From Research to Policy and Back
ERIC Educational Resources Information Center
Huston, Aletha C.
2008-01-01
Although science policy and social policy have distinct cultures, there are overlapping influences on both. Science policy decisions across the spectrum of basic and applied research are influenced by perceived social utility and the potential for solving current social problems. With the advent of evidence-based policy requirements, social…
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Bode, Michael F; Hilgendorf, Ingo
2018-06-09
Political bodies and professional societies acknowledge that translational research benefits from researchers trained in both, clinical medicine and basic science. Yet, few physicians undergoing clinical training in cardiology seek this dual career (Milewicz et al. J Clin Invest 125:3742-3747, 2015). The reasons are likely manifold, but with cardiology having become increasingly interventional and facing economic pressure, how much attention, credit, and encouragement is given to physicians interested in basic cardiovascular science? Having studied and worked in hospitals and laboratories, in both Germany and the USA, we aim to compare in this article how basic science education is currently integrated into cardiology training at German and US university hospitals, from medical school to more advanced career stages. By doing so, we hope to provide some outside perspectives to young physicians and decision makers alike, that may inspire changes to curricula in the respective countries and around the world.
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An opportunity: improving client services during disaster relief.
Helferich, Omar Keith; Griggs, John E
2006-11-01
Access to current, accurate, and relevant information is mandatory for effective disaster response. In-field observations, reviews of after-action reports, and basic research indicate that this most basic of requirements is not being met. Participating disaster recovery parties, in particular environmental health agencies, lack clarity about their exact roles and lack the most basic of technological solutions that could support any given role definition. There is a need, from both cost and training perspectives, for a single, integrated solution covering risk-based routine inspections, abnormalities, and major incidents.
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A Workshop for Developing Learning Modules for Science Classes Based on Biogeochemical Research
ERIC Educational Resources Information Center
Harrington, James M.; Gardner, Terrence G.; Amoozegar, Aziz; Andrews, Megan Y.; Rivera, Nelson A.; Duckworth, Owen W.
2013-01-01
A challenging aspect of educating secondary students is integrating complex scientific concepts related to modern research topics into lesson plans that students can relate to and understand at a basic level. One method of encouraging the achievement of learning outcomes is to use real-world applications and current research to fuel student…
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JPL basic research review. [research and advanced development
NASA Technical Reports Server (NTRS)
1977-01-01
Current status, projected goals, and results of 49 research and advanced development programs at the Jet Propulsion Laboratory are reported in abstract form. Areas of investigation include: aerodynamics and fluid mechanics, applied mathematics and computer sciences, environment protection, materials science, propulsion, electric and solar power, guidance and navigation, communication and information sciences, general physics, and chemistry.
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ERIC Educational Resources Information Center
Said, Asnah; Syarif, Edy
2016-01-01
This research aimed to evaluate of online tutorial program design by applying problem-based learning Research Methods currently implemented in the system of Open Distance Learning (ODL). The students must take a Research Methods course to prepare themselves for academic writing projects. Problem-based learning basically emphasizes the process of…
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Global oral health inequalities: dental caries task group--research agenda.
Pitts, N; Amaechi, B; Niederman, R; Acevedo, A-M; Vianna, R; Ganss, C; Ismail, A; Honkala, E
2011-05-01
The IADR Global Oral Health Inequalities Task Group on Dental Caries has synthesized current evidence and opinion to identify a five-year implementation and research agenda which should lead to improvements in global oral health, with particular reference to the implementation of current best evidence as well as integrated action to reduce caries and health inequalities between and within countries. The Group determined that research should: integrate health and oral health wherever possible, using common risk factors; be able to respond to and influence international developments in health, healthcare, and health payment systems as well as dental prevention and materials; and exploit the potential for novel funding partnerships with industry and foundations. More effective communication between and among the basic science, clinical science, and health promotion/public health research communities is needed. Translation of research into policy and practice should be a priority for all. Both community and individual interventions need tailoring to achieve a more equal and person-centered preventive focus and reduce any social gradient in health. Recommendations are made for both clinical and public health implementation of existing research and for caries-related research agendas in clinical science, health promotion/public health, and basic science.
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Humility in Learning: A Confucian Perspective
ERIC Educational Resources Information Center
Li, Jin
2016-01-01
Little research exists on humility in human learning and from a cultural perspective. This article reviews current research and conceptualizes humility as a basic human potential that can become a virtue when cultivated. But the cultivation depends on the cultural values placed on humility. Although humility is recognized in the West, ambivalence…
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The purpose of this presentation is to teach a course on analytical techniques, quality assurance, environmental research protocols, and basic soil environmental chemistry at the Environmental Health Center and Babes Bolyai University in Cluj, Romania. FOR FURTHER INFORMATI...
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Enhancing Student Learning with Brain-Based Research
ERIC Educational Resources Information Center
Bonnema, Ted R.
2009-01-01
This paper discusses brain-based learning and its relation to classroom instruction. A rapidly growing quantity of research currently exists regarding how the brain perceives, processes, and ultimately learns new information. In order to maximize their teaching efficacy, educators should have a basic understanding of key memory functions in the…
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Metacognition: Strategies for 'Fourthought.'
ERIC Educational Resources Information Center
Hanson, J. Robert
The brain's architecture serves as the basic model for theorizing about how the brain works. Current brain research confirms earlier suspicions that thoughtfulness has a great deal more complexity than the simplistic left/right distinctions of earlier research. This paper draws on the work of Carl Jung to propose the brain-psyche model as an…
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Third Grade Elementary Students' Perception of Science
ERIC Educational Resources Information Center
Demir, Metin
2015-01-01
The current study investigated which dimensions of scientific process are capitalized on by elementary school third graders to explain the concept of science at conceptual level. The study was conducted by using "Basic Qualitative Research", one of the qualitative research approaches with the participation of 225 elementary school third…
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The New Guide to Student Recruitment Marketing. The Best of "Case Currents."
ERIC Educational Resources Information Center
Smith, Virginia Carter, Ed.; Hunt, Susan, Ed.
The 53 best articles from "Case Currents" on student recruitment marketing are presented. The importance of a marketing plan and ways to apply basic marketing principles to recruitment programs are explained. Eight sections cover: exploring the marketing concept; conducting market research and putting the data to work; reaching out to recruit…
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Ride quality research techniques: Section on general techniques
NASA Technical Reports Server (NTRS)
1977-01-01
Information is gathered about the methods currently used for the study of ride quality in a variety of transportation modes by a variety of research organizations, including universities, Federal agencies, contracting firms, and private industries. Detailed descriptions of these techniques and their strengths and weaknesses, and identifying the organizations using such methods are presented. The specific efforts of the Group's participants, as well as a variety of feasible approaches not currently in use, are presented as methodological alternatives under the three basic factors which must be considered in ride quality studies: research techniques, research environments, and choice of subjects.
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Steckelings, U Muscha; De Mey, Jo G R; Pinto-Sietsma, Sara-Joan; Henrion, Daniel; Unger, Thomas
2011-01-01
The 15th Annual Meeting of the European Council of Cardiovascular Research brought together basic and clinical scientists working in the cardiovascular field in La Colle sur Loup, France. Upfront basic and clinical research addressing the mechanisms of disease, identification of biomarkers or development of new treatments was communicated in 101 presentations, 35 of them as a part of five on-topic oral sessions and three workshops. Three keynote lectures reviewed current knowledge and the latest data about mechanosensitive channels in pressure regulation, cell therapy in cardiovascular disease and mechanisms of cardiovascular risk associated with diabetic nephropathy. This article summarizes highlights of the oral sessions, workshops and keynote lectures.
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An overview of general aviation propulsion research programs at NASA Lewis Research Center
NASA Technical Reports Server (NTRS)
Willis, E. A.; Strack, W. C.
1981-01-01
The review covers near-term improvements for current-type piston engines, as well as studies and limited corroborative research on several advanced g/a engine concepts, including diesels, small turboprops and both piston and rotary stratified-charge engines. Also described is basic combustion research, cycle modeling and diagnostic instrumentation work that is required to make new engines a reality.
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Development of Independent-type Optical CT
NASA Astrophysics Data System (ADS)
Yamaguchi, Tatsushi; Shiozawa, Daigoro; Rokunohe, Toshiaki; Kida, Junzo; Zhang, Wei
Optical current transformers (optical CTs) have features that they can be made much smaller and lighter than conventional electromagnetic induction transformers by their simple structure, and contribute to improvement of equipment reliability because of their excellent surge resistance performance. Authors consider optical CTs to be next generation transformers, and are conducting research and development of optical CTs aiming to apply to measuring and protection in electric power systems. Specifically we developed an independent-type optical CT by utilizing basic data of optical CTs accumulated for large current characteristics, temperature characteristics, vibration resistance characteristics, and so on. In performance verification, type tests complying with IEC standards, such as short-time current tests, insulation tests, accuracy tests, and so on, showed good results. This report describes basic principle and configuration of optical CTs. After that, as basic characteristics of optical CTs, conditions and results of verification tests for dielectric breakdown characteristics of sensor fibers, large current characteristics, temperature characteristics, and vibration resistance characteristics are described. Finally, development outline of the independent-type optical CT aiming to apply to all digital substation and its type tests results are described.
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Epstein, Nurith; Fischer, Martin R.
2017-01-01
A lack of physician scientists as well as a high female dropout rate from academic medicine and basic life sciences is a concern in many countries. The current study analyzes academic career intentions within a sample of recent doctoral graduates from medicine and basic life sciences (N = 1109), focusing on research self-efficacy beliefs as explanatory variable of gender and disciplinary differences. To ensure that differences in research self-efficacy could not be attributed solely to objective scientific performance, we controlled for number of publications and dissertation grade. The results of multivariate analyses pointed to a strong and significant association between research self-efficacy and academic career intentions (ß = 0.49, p<0.001). The lower academic career intentions of medical doctoral graduates were no longer significant when controlling for research self-efficacy. Within the field of medicine, female doctoral graduates expressed lower research self-efficacy beliefs and academic career intentions. When controlling for research self-efficacy, the correlation between gender and academic career intention was no longer significant. In contrast, no gender differences were found within the basic life sciences with respect to neither academic career intentions nor research self-efficacy. PMID:28910334
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[RABIN MEDICAL CENTER - A TERTIARY CENTER OF EXCELLENCE IN SERVICE, TEACHING AND RESEARCH].
Niv, Yaron; Halpern, Eyran
2017-04-01
Rabin Medical Center (RMC) belongs to Clalit Health Services and is a tertiary, academic medical center with all the facilities of modern and advanced medicine. Annually in the RMC, 650,000 patients are treated in the outpatient clinics, and 100,000 patients are hospitalized in the hospital departments. All these patients are treated by 4500 devoted staff members, including 1000 physicians and 2000 nurses. RMC is one of the largest, centrally located medical centers for medical and nursing students' education in Israel, taking place in clinical departments, as well as in basic sciences courses. We also have a nursing school attached to the hospital. Our vision supports excellence in research. We have a special Research Department that supports RMC researchers, with research coordinators, and all the relevant facilities to assist in clinical and basic science studies. We also promote collaboration efforts with many academic centers in Israel and abroad. The scope of RMC research is broad, including 700 new studies every year and 1500 active studies currently. This issue of Harefuah is dedicated to the clinical and basic science research conducted at RMC with original papers presenting research performed by our departments and laboratories.
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Epstein, Nurith; Fischer, Martin R
2017-01-01
A lack of physician scientists as well as a high female dropout rate from academic medicine and basic life sciences is a concern in many countries. The current study analyzes academic career intentions within a sample of recent doctoral graduates from medicine and basic life sciences (N = 1109), focusing on research self-efficacy beliefs as explanatory variable of gender and disciplinary differences. To ensure that differences in research self-efficacy could not be attributed solely to objective scientific performance, we controlled for number of publications and dissertation grade. The results of multivariate analyses pointed to a strong and significant association between research self-efficacy and academic career intentions (ß = 0.49, p<0.001). The lower academic career intentions of medical doctoral graduates were no longer significant when controlling for research self-efficacy. Within the field of medicine, female doctoral graduates expressed lower research self-efficacy beliefs and academic career intentions. When controlling for research self-efficacy, the correlation between gender and academic career intention was no longer significant. In contrast, no gender differences were found within the basic life sciences with respect to neither academic career intentions nor research self-efficacy.
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Anatomy integration blueprint: A fourth-year musculoskeletal anatomy elective model.
Lazarus, Michelle D; Kauffman, Gordon L; Kothari, Milind J; Mosher, Timothy J; Silvis, Matthew L; Wawrzyniak, John R; Anderson, Daniel T; Black, Kevin P
2014-01-01
Current undergraduate medical school curricular trends focus on both vertical integration of clinical knowledge into the traditionally basic science-dedicated curricula and increasing basic science education in the clinical years. This latter type of integration is more difficult and less reported on than the former. Here, we present an outline of a course wherein the primary learning and teaching objective is to integrate basic science anatomy knowledge with clinical education. The course was developed through collaboration by a multi-specialist course development team (composed of both basic scientists and physicians) and was founded in current adult learning theories. The course was designed to be widely applicable to multiple future specialties, using current published reports regarding the topics and clinical care areas relying heavily on anatomical knowledge regardless of specialist focus. To this end, the course focuses on the role of anatomy in the diagnosis and treatment of frequently encountered musculoskeletal conditions. Our iterative implementation and action research approach to this course development has yielded a curricular template for anatomy integration into clinical years. Key components for successful implementation of these types of courses, including content topic sequence, the faculty development team, learning approaches, and hidden curricula, were developed. We also report preliminary feedback from course stakeholders and lessons learned through the process. The purpose of this report is to enhance the current literature regarding basic science integration in the clinical years of medical school. © 2014 American Association of Anatomists.
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Forest genetics research at the University of Michigan
Burton V. Barnes
1970-01-01
The purpose of the research program, as evidenced by results as well as current research and future direction, is to add to the knowledge of the ecology and genetics of forest trees. Although we are interested in the practical gains that are possible and being realized in practical tree improvement, our contribution is in basic studies that stimulate and challenge...
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Global Oral Health Inequalities
Pitts, N.; Amaechi, B.; Niederman, R.; Acevedo, A.-M.; Vianna, R.; Ganss, C.; Ismail, A.; Honkala, E.
2011-01-01
The IADR Global Oral Health Inequalities Task Group on Dental Caries has synthesized current evidence and opinion to identify a five-year implementation and research agenda which should lead to improvements in global oral health, with particular reference to the implementation of current best evidence as well as integrated action to reduce caries and health inequalities between and within countries. The Group determined that research should: integrate health and oral health wherever possible, using common risk factors; be able to respond to and influence international developments in health, healthcare, and health payment systems as well as dental prevention and materials; and exploit the potential for novel funding partnerships with industry and foundations. More effective communication between and among the basic science, clinical science, and health promotion/public health research communities is needed. Translation of research into policy and practice should be a priority for all. Both community and individual interventions need tailoring to achieve a more equal and person-centered preventive focus and reduce any social gradient in health. Recommendations are made for both clinical and public health implementation of existing research and for caries-related research agendas in clinical science, health promotion/public health, and basic science. PMID:21490233
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The State of Melanoma: Challenges and Opportunities
Merlino, Glenn; Herlyn, Meenhard; Fisher, David E.; Bastian, Boris C.; Flaherty, Keith T.; Davies, Michael A.; Wargo, Jennifer A.; Curiel-Lewandrowski, Clara; Weber, Michael J.; Leachman, Sancy A.; Soengas, Maria S.; McMahon, Martin; Harbour, J. William; Swetter, Susan M.; Aplin, Andrew E.; Atkins, Michael B.; Bosenberg, Marcus W.; Dummer, Reinhard; Gershenwald, Jeff; Halpern, Allan C.; Herlyn, Dorothee; Karakousis, Giorgos C.; Kirkwood, John M.; Krauthammer, Michael; Lo, Roger S.; Long, Georgina V.; McArthur, Grant; Ribas, Antoni; Schuchter, Lynn; Sosman, Jeffrey A.; Smalley, Keiran S.; Steeg, Patricia; Thomas, Nancy E.; Tsao, Hensin; Tueting, Thomas; Weeraratna, Ashani; Xu, George; Lomax, Randy; Martin, Alison; Silverstein, Steve; Turnham, Tim; Ronai, Ze’ev A.
2017-01-01
The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas—diagnosis/early detection, prevention, tumor cell dormancy (including metastasis) and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts per the current status, challenges and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report. PMID:27087480
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Update on Research and Leadership. Vol. 21, No. 1. Fall 2009
ERIC Educational Resources Information Center
Bragg, Debra D., Ed.; Taylor, Jason L., Ed.
2009-01-01
This edition features current research, practice, and policy related to the Joyce Foundation's Shifting Gears initiative beginning with an interview with Whitney Smith, Manager of the Employment Program at the Joyce Foundation. Julie Strawn, Center for Law and Social Policy, presents a national perspective of basic skills reform efforts similar to…
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ERIC Educational Resources Information Center
Burnett, I. Emett, Jr.; Pankake, Anita M.
Although much of the current school reform movement relies on the basic assumption of effective elementary school administration, insufficient effort has been made to synthesize key concepts found in organizational theory and management studies with relevant effective schools research findings. This paper attempts such a synthesis to help develop…
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Diversity Recruiting: Overview of Practices and Benchmarks. CERI Research Brief 4-2013
ERIC Educational Resources Information Center
Gardner, Phil
2013-01-01
Little information exists on the basic elements of diversity recruiting on college campuses. A set of questions was developed for the Collegiate Employment Research Institute's (CERI's) annual college hiring survey that attempted to capture the current practices and benchmarks being employed by organizations in their diversity recruiting programs.…
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40 CFR 26.116 - General requirements for informed consent.
Code of Federal Regulations, 2011 CFR
2011-07-01
... PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or... policy, no investigator may involve a human being as a subject in research covered by this policy unless... subject (or to the embryo or fetus, if the subject is or may become pregnant) which are currently...
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Programme Implementation in Social and Emotional Learning: Basic Issues and Research Findings
ERIC Educational Resources Information Center
Durlak, Joseph A.
2016-01-01
This paper discusses the fundamental importance of achieving quality implementation when assessing the impact of social and emotional learning interventions. Recent findings in implementation science are reviewed that include a definition of implementation, its relation to programme outcomes, current research on the factors that affect…
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ERIC Educational Resources Information Center
Bingman, Mary Beth
Action research focused on developing approaches local programs can use to document outcomes of student participation in adult basic education (ABE) programs. Teams of teachers and administrators from three ABE programs examined current documentation practices, were introduced to approaches to documentaion, and developed documentation processes…
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Nursing research and bibliographic citation models.
Angordans, Jordi Piqué; Puig, Ramón Camaño; Noguera, Carmen Piqué
2009-01-01
This research focuses on the analysis of how nursing journals publish their papers. Basically, two models are analyzed, Vancouver, by the International Committee of Medical Journal Editors, and APA by the American Psychological Association. Their advantages and disadvantages are discussed. In view of how research papers are currently published and how research is judged, the authors propose that nursing journals adopt their own model, irrespective of how medical professionals publish.
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Cherenkov water detector NEVOD
NASA Astrophysics Data System (ADS)
Petrukhin, A. A.
2015-05-01
A unique multipurpose Cherenkov water detector, the NEVOD facility, uses quasispherical measuring modules to explore all the basic components of cosmic rays on Earth's surface, including neutrinos. Currently, the experimental complex includes the Cherenkov water detector, a calibration telescope system, and a coordinate detector. This paper traces the basic development stages of NEVOD, examines research directions, presents the results obtained, including the search for the solution to the 'muon puzzle', and discusses possible future development prospects.
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Electronic Data Interchange in U.S. Navy Contracting Activities
1992-12-01
the basic research question, the following subsidiary questions were asked: 1. How is EDI being used in the private sector and within the Department of...eliminated by using EDI transactions. According to a DoD small business EDI Guide , (DLA Partnership, 1991, p.15) in financial management applications, a...and to place orders against basic ordering agreements (BOA). The ASO is currently transmitting the ASC X12 850 [Purchase Order] to approximately 25
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Kidney disease and obesity: epidemiology, mechanisms and treatment.
Câmara, Niels Olsen Saraiva; Iseki, Kunitoshi; Kramer, Holly; Liu, Zhi-Hong; Sharma, Kumar
2017-03-01
The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed.
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Nelson, Barnaby; Thompson, Andrew; Chanen, Andrew M; Amminger, Günther Paul; Yung, Alison R
2013-08-01
Research in the phenomenological tradition suggests that the schizophrenia spectrum is characterized by disturbance of the 'basic' self, whereas borderline personality disorder involves disturbance of the 'narrative' self. The current study investigated this proposal in an ultra-high risk for psychosis sample. The sample consisted of 42 ultra-high-risk participants with a mean age of 19.22 years. Basic self-disturbance was measured using the Examination of Anomalous Self-Experience. Borderline personality pathology was measured using the borderline personality disorder items from the structured clinical interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) Axis II Personality Questionnaire. No correlation was found between the measures of basic self-disturbance and borderline personality pathology. The finding is consistent with the proposal that different (although not mutually exclusive) types of self-disturbance characterize the schizophrenia spectrum and borderline personality disorder. Further research should further examine the question of basic self-disturbance in patients with established borderline personality disorder. © 2013 Wiley Publishing Asia Pty Ltd.
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Atmospheric and Space Sciences: Ionospheres and Plasma Environments
NASA Astrophysics Data System (ADS)
Yiǧit, Erdal
2018-01-01
The SpringerBriefs on Atmospheric and Space Sciences in two volumes presents a concise and interdisciplinary introduction to the basic theory, observation & modeling of atmospheric and ionospheric coupling processes on Earth. The goal is to contribute toward bridging the gap between meteorology, aeronomy, and planetary science. In addition recent progress in several related research topics, such atmospheric wave coupling and variability, is discussed. Volume 1 will focus on the atmosphere, while Volume 2 will present the ionospheres and the plasma environments. Volume 2 is aimed primarily at (research) students and young researchers that would like to gain quick insight into the basics of space sciences and current research. In combination with the first volume, it also is a useful tool for professors who would like to develop a course in atmospheric and space physics.
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An Industry Picture of U. S. Science Policy.
ERIC Educational Resources Information Center
David, Edward E., Jr.
1986-01-01
Offers perspectives on the status and direction of federal science policy. Assesses current efforts dealing with megaprojects, basic research, and cooperative projects. Provides suggestions for improving federal science policy so as to better promote industrial competitiveness. (ML)
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ERIC Educational Resources Information Center
Thomas, Lewis
1981-01-01
Presents a viewpoint concerning the impact of recent scientific advances on society. Discusses biological discoveries, space exploration, computer technology, development of new astronomical theories, the behavioral sciences, and basic research. Challenges to keeping science current with technological advancement are also discussed. (DS)
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Targeting Vascular Neural Network in Intracerebral Hemorrhage.
Yin, Yi; Ge, Hongfei; Zhang, John H; Feng, Hua
2017-01-01
Intracerebral hemorrhage (ICH) is a common type of stroke associated with high mortality and morbidity. Recent randomized controlled trials could not prove that the current strategies are effective at improving the final outcome of the ICH patients. Here we want to explore potential intervention targets for ICH based on the framework of the vascular neural network (VNN). In this review, a brief history of the evolution of stroke pathophysiology from humoral theory to VNN is discussed. As current literature on pathophysiology of ICH is mainly focused on neuroprotection, here we want to evolve the central paradigm towards VNN. We stress mechanisms of vascular disruption and impaired blood flow harmony, which are clinically relevant but have received less attention in basic research. We propose that VNN could be a robust and practical paradigm in both ICH basic research and clinical practice. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
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Hezel, Marcus; von Usslar, Kathrin; Kurzweg, Thiemo; Lörincz, Balazs B; Knecht, Rainald
2016-04-01
This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.
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Lab to farm: applying research on plant genetics and genomics to crop improvement.
Ronald, Pamela C
2014-06-01
Over the last 300 years, plant science research has provided important knowledge and technologies for advancing the sustainability of agriculture. In this Essay, I describe how basic research advances have been translated into crop improvement, explore some lessons learned, and discuss the potential for current and future contribution of plant genetic improvement technologies to continue to enhance food security and agricultural sustainability.
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U.S. Army Research Institute Program in Basic Research - FY 2007
2008-05-01
learner characteristics (e.g., cognitive ability or learning style), depth and complexity of content, or instructional design characteristics. There...trainers to think about ways of making learning purposeful. The effects of cognitive load on learning were minimally explored in the current research...Achievement in Complex Learning Environments as a Function of Information Processing Ability , Knowledge, and Self-Control Josep h F . F ag an
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Unified control/structure design and modeling research
NASA Technical Reports Server (NTRS)
Mingori, D. L.; Gibson, J. S.; Blelloch, P. A.; Adamian, A.
1986-01-01
To demonstrate the applicability of the control theory for distributed systems to large flexible space structures, research was focused on a model of a space antenna which consists of a rigid hub, flexible ribs, and a mesh reflecting surface. The space antenna model used is discussed along with the finite element approximation of the distributed model. The basic control problem is to design an optimal or near-optimal compensator to suppress the linear vibrations and rigid-body displacements of the structure. The application of an infinite dimensional Linear Quadratic Gaussian (LQG) control theory to flexible structure is discussed. Two basic approaches for robustness enhancement were investigated: loop transfer recovery and sensitivity optimization. A third approach synthesized from elements of these two basic approaches is currently under development. The control driven finite element approximation of flexible structures is discussed. Three sets of finite element basic vectors for computing functional control gains are compared. The possibility of constructing a finite element scheme to approximate the infinite dimensional Hamiltonian system directly, instead of indirectly is discussed.
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Symbolic Interaction and Applied Social Research: A FOCUS ON TRANSLATIONAL SCIENCE RESEARCH1.
Kotarba, Joseph A
2014-08-01
In symbolic interaction, a traditional yet unfortunate and unnecessary distinction has been made between basic and applied research. The argument has been made that basic research is intended to generate new knowledge, whereas applied research is intended to apply knowledge to the solution of practical (social and organizational) problems. I will argue that the distinction between basic and applied research in symbolic interaction is outdated and dysfunctional. The masters of symbolic interactionist thought have left us a proud legacy of shaping their scholarly thinking and inquiry in response to and in light of practical issues of the day (e.g., Znaniecki, and Blumer). Current interactionist work continues this tradition in topical areas such as social justice studies. Applied research, especially in term of evaluation and needs assessment studies, can be designed to serve both basic and applied goals. Symbolic interaction provides three great resources to do this. The first is its orientation to dynamic sensitizing concepts that direct research and ask questions instead of supplying a priori and often impractical answers. The second is its orientation to qualitative methods, and appreciation for the logic of grounded theory. The third is interactionism's overall holistic approach to interfacing with the everyday life world. The primary illustrative case here is the qualitative component of the evaluation of an NIH-funded, translational medical research program. The qualitative component has provided interactionist-inspired insights into translational research, such as examining cultural change in medical research in terms of changes in the form and content of formal and informal discourse among scientists; delineating the impact of significant symbols such as "my lab" on the social organization of science; and appreciating the essence of the self-concept "scientist" on the increasingly bureaucratic and administrative identities of medical researchers. This component has also contributed to the basic social scientific literature on complex organizations and the self.
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The Clinical Value, Principle, and Basic Practical Technique of Mindfulness Intervention.
Zou, Tao; Wu, Chenghan; Fan, Xiaoduo
2016-06-25
Mindfulness intervention is a psychotherapy based on the Buddhist practice of meditation, combining the theories and methodology of contemporary psychology. The empirical research in recent years has indicated that mindfulness intervention yields favorable results including reduction of depression relapse, alleviation of the symptoms of depression and anxiety, reduction of substance abuse, relief of pain, blood pressure management, enhancement of immunity, and improvement of sleep. Currently, mindfulness therapy has become the mainstream of psychotherapy in the realm of European and American psychotherapy. The fields of psychology and psychotherapy in China have also begun to introduce mindfulness intervention in recent years. However, there is a lack of relevant practice and research in the field of clinical mental health. This article will briefly introduce the concept of mindfulness, the basic mechanism of the intervention, and the basic skills and guidelines in clinical practice.
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Gunnar, Megan R; Fisher, Philip A
2006-01-01
A major focus in developmental psychopathology is on understanding developmental mechanisms and, armed with this information, intervening to improve children's outcomes. Translational research attempts to bridge the distance between understanding and intervention. In the collaborations that have formed the core of our research network on early experience, stress, and prevention science, we have focused on translating basic research on early experiences and stress neurobiology into preventive interventions for neglected and abused children. Our experiences in attempting to move from bench to bedside have led us to recognize the many challenges that face translational researchers. This review provides a brief synopsis of the animal model literature on early experience and stress neurobiology from which we glean several key bridging issues. We then review what is currently known about the impact of childhood neglect and abuse on stress neurobiology in human adults and children. Next, we describe how this work has informed the evaluation of our preventive interventions with maltreated children. Finally, we discuss several considerations that should facilitate a more complete integration of basic research on early experience and stress neurobiology into preventive intervention strategies.
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Standardized Radiation Shield Design Methods: 2005 HZETRN
NASA Technical Reports Server (NTRS)
Wilson, John W.; Tripathi, Ram K.; Badavi, Francis F.; Cucinotta, Francis A.
2006-01-01
Research committed by the Langley Research Center through 1995 resulting in the HZETRN code provides the current basis for shield design methods according to NASA STD-3000 (2005). With this new prominence, the database, basic numerical procedures, and algorithms are being re-examined with new methods of verification and validation being implemented to capture a well defined algorithm for engineering design processes to be used in this early development phase of the Bush initiative. This process provides the methodology to transform the 1995 HZETRN research code into the 2005 HZETRN engineering code to be available for these early design processes. In this paper, we will review the basic derivations including new corrections to the codes to insure improved numerical stability and provide benchmarks for code verification.
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Topological classification of periodic orbits in the Kuramoto-Sivashinsky equation
NASA Astrophysics Data System (ADS)
Dong, Chengwei
2018-05-01
In this paper, we systematically research periodic orbits of the Kuramoto-Sivashinsky equation (KSe). In order to overcome the difficulties in the establishment of one-dimensional symbolic dynamics in the nonlinear system, two basic periodic orbits can be used as basic building blocks to initialize cycle searching, and we use the variational method to numerically determine all the periodic orbits under parameter ν = 0.02991. The symbolic dynamics based on trajectory topology are very successful for classifying all short periodic orbits in the KSe. The current research can be conveniently adapted to the identification and classification of periodic orbits in other chaotic systems.
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[Symptoms diagnosis and treatment of dyscalulia].
Ise, Elena; Schulte-Körne, Gerd
2013-07-01
Children with dyscalculia show deficits in basic numerical processing which cause difficulties in the acquisition of mathematical skills. This article provides an overview of current research findings regarding the symptoms, cause, and prognosis of dyscalculia, and it summarizes recent developments in the diagnosis, early intervention, and treatment thereof. Diagnosis has improved recently because newly developed tests focus not only on the math curriculum, but also on basic skills found to be impaired in dyscalculia. A controversial debate continues with regard to IQ achievement discrepancy. International studies have demonstrated the effectiveness of specialized interventions. This article summarizes the research findings from intervention studies, describes different treatment approaches, and discusses implications for clinical practice.
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Capabilities of radar as they might relate to entomological studies
NASA Technical Reports Server (NTRS)
Skolnik, M. I.
1979-01-01
A tutoral background of radar capabilities and its potential for insect research is provided. The basic principles and concepts of radar were reviewed. Information on current radar equipment was examined. Specific issues related to insect research included; target cross-section, radar frequency, tracking target recognition and false alarms, clutter reduction, radar transmitter power, and ascertained atmospheric processes.
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Implementation of Online Reading Assessments to Encourage Reading Interests
ERIC Educational Resources Information Center
Rahayu, Endang Yuliani; Februariyanti, Herni
2015-01-01
The current study reports a two-year research project funded by the Government of the Republic of Indonesia through a competitive research scheme. The aim is basically to respond to the fact most university students have very low interests in reading activities, such as finding out important information for their term papers as assigned by the…
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Turisco, Fran; Keogh, Diane; Stubbs, Connie; Glaser, John; Crowley, William F
2005-12-01
Little information exists about the incorporation of information technologies (ITs) into clinical research processes within US academic health centers (AHCs). Therefore, we queried a group of 37 leading AHCs regarding their current status and future plans in clinical research IT. The survey specifically inquired about the presence or absence of basic infrastructure and IT support requirements; individual applications needed to support study preparation, study conduct, and its administrative support; and integration of data from basic research, clinical trials, and the clinical information systems increasingly used in health care delivery. Of the 37 AHCs, 78% responded. All strongly agreed that a "state-of-the-art" clinical research IT program would be ideal today and will be essential tomorrow. Nonetheless, no AHC currently has an IT solution that even approached this ideal. No AHC reported having all of the essential management foundations (ie, a coherent vision, an overall strategy, a governance structure, and a dedicated budget) necessary to launch and sustain a truly successful implementation of a cohesive clinical research IT platform. Many had achieved breakthroughs in individual aspects of clinical research IT, for example, adverse event reporting systems or consent form templates. However, overall implementation of IT to support clinical research is uneven and insufficient. These data document a substantial gap in clinical research IT investments in leading US AHCs. Linking the clinical research IT enterprise with its clinical operations in a meaningful fashion remains a crucial strategic goal of AHCs. If they are to continue to serve as the "translational research engines" that our society expects, AHCs must recognize this gap and allocate substantial resource deployment to remedying this situation.
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Fundamentals in Biostatistics for Research in Pediatric Dentistry: Part I - Basic Concepts.
Garrocho-Rangel, J A; Ruiz-Rodríguez, M S; Pozos-Guillén, A J
The purpose of this report was to provide the reader with some basic concepts in order to better understand the significance and reliability of the results of any article on Pediatric Dentistry. Currently, Pediatric Dentists need the best evidence available in the literature on which to base their diagnoses and treatment decisions for the children's oral care. Basic understanding of Biostatistics plays an important role during the entire Evidence-Based Dentistry (EBD) process. This report describes Biostatistics fundamentals in order to introduce the basic concepts used in statistics, such as summary measures, estimation, hypothesis testing, effect size, level of significance, p value, confidence intervals, etc., which are available to Pediatric Dentists interested in reading or designing original clinical or epidemiological studies.
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ERIC Educational Resources Information Center
Periago, M. Cristina; Bohigas, Xavier
2005-01-01
The aim of this research was to evaluate and analyse second-year industrial engineering and chemical engineering students prior knowledge of conceptual aspects of "circuit theory". Specifically, we focused on the basic concepts of electric potential and current intensity and on the fundamental relationship between them as expressed by Ohm's law.…
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Symbolic Interaction and Applied Social Research
Kotarba, Joseph A.
2014-01-01
In symbolic interaction, a traditional yet unfortunate and unnecessary distinction has been made between basic and applied research. The argument has been made that basic research is intended to generate new knowledge, whereas applied research is intended to apply knowledge to the solution of practical (social and organizational) problems. I will argue that the distinction between basic and applied research in symbolic interaction is outdated and dysfunctional. The masters of symbolic interactionist thought have left us a proud legacy of shaping their scholarly thinking and inquiry in response to and in light of practical issues of the day (e.g., Znaniecki, and Blumer). Current interactionist work continues this tradition in topical areas such as social justice studies. Applied research, especially in term of evaluation and needs assessment studies, can be designed to serve both basic and applied goals. Symbolic interaction provides three great resources to do this. The first is its orientation to dynamic sensitizing concepts that direct research and ask questions instead of supplying a priori and often impractical answers. The second is its orientation to qualitative methods, and appreciation for the logic of grounded theory. The third is interactionism’s overall holistic approach to interfacing with the everyday life world. The primary illustrative case here is the qualitative component of the evaluation of an NIH-funded, translational medical research program. The qualitative component has provided interactionist-inspired insights into translational research, such as examining cultural change in medical research in terms of changes in the form and content of formal and informal discourse among scientists; delineating the impact of significant symbols such as "my lab" on the social organization of science; and appreciating the essence of the self-concept "scientist" on the increasingly bureaucratic and administrative identities of medical researchers. This component has also contributed to the basic social scientific literature on complex organizations and the self. PMID:25221375
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Influence of ingredients and chemical components on the quality of Chinese steamed bread.
Zhu, Fan
2014-11-15
Chinese steamed bread (CSB) is a staple food in China since ancient time. The basic ingredients include wheat flour, yeast/sourdough, and water. Current consumer trends urge the production of CSB on a large scale as well as the formulation of healthier CSB with specific nutritional benefits. This requires a better definition of the relationship between the properties of ingredients/chemical components and CSB quality. This review summarises the recent advances in understanding the roles of basic and optional ingredients and their chemical components in the appearance, textural, sensory, and shelf-life properties of CSB, and provides suggestions for further research to match the current trends. Copyright © 2014 Elsevier Ltd. All rights reserved.
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ERIC Educational Resources Information Center
Department of the Interior, Denver, CO. Engineering and Research Center.
Subjects covered in this text are controlling the hydroelectric generator, generator excitation, basic principles of direct current generation, direction of current flow, basic alternating current generator, alternating and direct current voltage outputs, converting alternating current to direct current, review of the basic generator and…
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Lab to Farm: Applying Research on Plant Genetics and Genomics to Crop Improvement
Ronald, Pamela C.
2014-01-01
Over the last 300 years, plant science research has provided important knowledge and technologies for advancing the sustainability of agriculture. In this Essay, I describe how basic research advances have been translated into crop improvement, explore some lessons learned, and discuss the potential for current and future contribution of plant genetic improvement technologies to continue to enhance food security and agricultural sustainability. PMID:24915201
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Losing Your Gut Feelings. Intuition in Depression
Remmers, Carina; Michalak, Johannes
2016-01-01
Whereas in basic research, intuition has become a topic of great interest, clinical research and depression research in specific have not applied to the topic of intuition, yet. This is astonishing because a well-known phenomenon during depression is that patients have difficulties to judge and decide. In contrast to healthy individuals who take most daily life decisions intuitively (Kahneman, 2011), depressed individuals seem to have difficulties to come to fast and adaptive decisions. The current article pursues three goals. First, our aim is to establish the hypothesis that intuition is impaired in depression against the background of influential theoretical accounts as well as empirical evidence from basic and clinical research. The second aim of the current paper is to provide explanations for recent findings on the depression-intuition interplay and to present directions for future research that may help to broaden our understanding of decision difficulties in depression. Third, we seek to propose ideas on how therapeutic interventions can support depressed individuals in taking better decisions. Even though our knowledge regarding this topic is still limited, we will tentatively launch the idea that an important first step may be to enhance patients’ access to intuitions. Overall, this paper seeks to introduce the topic of intuition to clinical research on depression and to hereby set the stage for upcoming theory and practice. PMID:27602015
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Losing Your Gut Feelings. Intuition in Depression.
Remmers, Carina; Michalak, Johannes
2016-01-01
Whereas in basic research, intuition has become a topic of great interest, clinical research and depression research in specific have not applied to the topic of intuition, yet. This is astonishing because a well-known phenomenon during depression is that patients have difficulties to judge and decide. In contrast to healthy individuals who take most daily life decisions intuitively (Kahneman, 2011), depressed individuals seem to have difficulties to come to fast and adaptive decisions. The current article pursues three goals. First, our aim is to establish the hypothesis that intuition is impaired in depression against the background of influential theoretical accounts as well as empirical evidence from basic and clinical research. The second aim of the current paper is to provide explanations for recent findings on the depression-intuition interplay and to present directions for future research that may help to broaden our understanding of decision difficulties in depression. Third, we seek to propose ideas on how therapeutic interventions can support depressed individuals in taking better decisions. Even though our knowledge regarding this topic is still limited, we will tentatively launch the idea that an important first step may be to enhance patients' access to intuitions. Overall, this paper seeks to introduce the topic of intuition to clinical research on depression and to hereby set the stage for upcoming theory and practice.
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Estimating the NIH efficient frontier.
Bisias, Dimitrios; Lo, Andrew W; Watkins, James F
2012-01-01
The National Institutes of Health (NIH) is among the world's largest investors in biomedical research, with a mandate to: "…lengthen life, and reduce the burdens of illness and disability." Its funding decisions have been criticized as insufficiently focused on disease burden. We hypothesize that modern portfolio theory can create a closer link between basic research and outcome, and offer insight into basic-science related improvements in public health. We propose portfolio theory as a systematic framework for making biomedical funding allocation decisions-one that is directly tied to the risk/reward trade-off of burden-of-disease outcomes. Using data from 1965 to 2007, we provide estimates of the NIH "efficient frontier", the set of funding allocations across 7 groups of disease-oriented NIH institutes that yield the greatest expected return on investment for a given level of risk, where return on investment is measured by subsequent impact on U.S. years of life lost (YLL). The results suggest that NIH may be actively managing its research risk, given that the volatility of its current allocation is 17% less than that of an equal-allocation portfolio with similar expected returns. The estimated efficient frontier suggests that further improvements in expected return (89% to 119% vs. current) or reduction in risk (22% to 35% vs. current) are available holding risk or expected return, respectively, constant, and that 28% to 89% greater decrease in average years-of-life-lost per unit risk may be achievable. However, these results also reflect the imprecision of YLL as a measure of disease burden, the noisy statistical link between basic research and YLL, and other known limitations of portfolio theory itself. Our analysis is intended to serve as a proof-of-concept and starting point for applying quantitative methods to allocating biomedical research funding that are objective, systematic, transparent, repeatable, and expressly designed to reduce the burden of disease. By approaching funding decisions in a more analytical fashion, it may be possible to improve their ultimate outcomes while reducing unintended consequences.
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Space human factors discipline science plan
NASA Technical Reports Server (NTRS)
1991-01-01
The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the comprehensive areas of behavior, performance, and human factors. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, defines critical questions in the subdiscipline areas, and identifies technological priorities. It covers the significant research areas critical to NASA's programmatic requirements for the Extended Duration Orbiter, Space Station Freedom, and Exploration mission science activities. These science activities include ground-based and flight; basic, applied and operational; and animal and human research and development. This document contains a general plan that will be used by both NASA Headquarters program offices and the field centers to review and plan basic, applied, and operational research and development activities, both intramural and extramural, in this area.
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Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products.
Fowler, Christie D; Gipson, Cassandra D; Kleykamp, Bethea A; Rupprecht, Laura E; Harrell, Paul T; Rees, Vaughan W; Gould, Thomas J; Oliver, Jason; Bagdas, Deniz; Damaj, M Imad; Schmidt, Heath D; Duncan, Alexander; De Biasi, Mariella
2018-06-07
Scientific discoveries over the past few decades have provided significant insight into the abuse liability and negative health consequences associated with tobacco and nicotine-containing products. While many of these advances have led to the development of policies and laws that regulate access to and formulations of these products, further research is critical to guide future regulatory efforts, especially as novel nicotine-containing products are introduced and selectively marketed to vulnerable populations. In this narrative review, we provide an overview of the scientific findings that have impacted regulatory policy and discuss considerations for further translation of science into policy decisions. We propose that open, bidirectional communication between scientists and policy makers is essential to develop transformative preventive- and intervention-focused policies and programs to reduce appeal, abuse liability, and toxicity of the products. Through these types of interactions, collaborative efforts to inform and modify policy have the potential to significantly decrease the use of tobacco and alternative nicotine products and thus enhance health outcomes for individuals. This work addresses current topics in the nicotine and tobacco research field to emphasize the importance of basic science research and provide examples of how it can be utilized to inform public policy. In addition to relaying current thoughts on the topic from experts in the field, the article encourages continued efforts and communication between basic scientists and policy officials.
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Basic research for the geodynamics program
NASA Technical Reports Server (NTRS)
Mueller, I. I.
1985-01-01
The current technical objectives for the geodynamics program consist of (1) optimal utilization of laser and Very Long Baseline Interferometry (VLBI) observations for reference frames for geodynamics; (2) utilization of range difference observations in geodynamics; and (3) estimation techniques in crustal deformation analysis.
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Current research on aviation weather (bibliography)
NASA Technical Reports Server (NTRS)
Durham, D. E.; Frost, W.
1978-01-01
This bibliography of 326 readily usable references of basic and applied research programs related to the various areas of aviation meteorology was assembled. A literature search was conducted which surveyed the major abstract publications such as the International Aerospace Abstracts, the Meteorological and Geoastrophysical Abstracts, and the Scientific and Technical Aerospace Reports. In addition, NASA and DOT computer literature searches were run; and NASA, NOAA, and FAA research project managers were requested to provide writeups on their ongoing research.
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Integrated fundamental research on current collection
NASA Astrophysics Data System (ADS)
Kuhlmann-Wilsdorf, Doris
1992-10-01
The aim of our research has been to add to basic understanding in the area of current collection with particular emphasis on topics likely to benefit practical objectives. Under sponsorship of this contract twenty three papers were published in the international literature as listed in the last section. Additionally, thirteen invited lectures and eleven contributed lectures on various aspects of this research were delivered at Universities, Research Laboratories and International Conferences by the Principal Investigator and co-workers. Last not least, development of a novel metal fiber material for sliding electrical contacts has been continued with much success. This is expected to become very useful for making metal fiber brushes for homopolar motors/generators as well as for EML armatures.
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TH-F-202-03: Advances in MRI for Radiation Therapy
DOE Office of Scientific and Technical Information (OSTI.GOV)
Cai, J.
MRI has excellent soft tissue contrast and can provide both anatomical and physiological information. It is becoming increasingly important in radiation therapy for treatment planning, image-guided radiation therapy, and treatment assessment. It is critically important at this time point to educate and update our medical physicists about MRI to prepare for the upcoming surge of MRI applications in radiation therapy. This session will review important basics of MR physics, pulse sequence designs, and current radiotherapy application, as well as showcase exciting new developments in MRI that can be potentially useful in radiation therapy. Learning Objectives: To learn basics of MRmore » physics and understand the differences between various pulse sequences To review current applications of MRI in radiation therapy.To discuss recent MRI advances for future MRI guided radiation therapy Partly supported by NIH (1R21CA165384).; W. Miller, Research supported in part by Siemens Healthcare; G. Li, My clinical research is in part supported by NIH U54CA137788. I have a collaborative research project with Philips Healthcare.; J. Cai, jing cai.« less
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TH-F-202-00: MRI for Radiation Therapy
DOE Office of Scientific and Technical Information (OSTI.GOV)
NONE
MRI has excellent soft tissue contrast and can provide both anatomical and physiological information. It is becoming increasingly important in radiation therapy for treatment planning, image-guided radiation therapy, and treatment assessment. It is critically important at this time point to educate and update our medical physicists about MRI to prepare for the upcoming surge of MRI applications in radiation therapy. This session will review important basics of MR physics, pulse sequence designs, and current radiotherapy application, as well as showcase exciting new developments in MRI that can be potentially useful in radiation therapy. Learning Objectives: To learn basics of MRmore » physics and understand the differences between various pulse sequences To review current applications of MRI in radiation therapy.To discuss recent MRI advances for future MRI guided radiation therapy Partly supported by NIH (1R21CA165384).; W. Miller, Research supported in part by Siemens Healthcare; G. Li, My clinical research is in part supported by NIH U54CA137788. I have a collaborative research project with Philips Healthcare.; J. Cai, jing cai.« less
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Yu, Yingyan
2014-01-01
Histopathological classification is in a pivotal position in both basic research and clinical diagnosis and treatment of gastric cancer. Currently, there are different classification systems in basic science and clinical application. In medical literatures, different classifications are used including Lauren and WHO systems, which have confused many researchers. Lauren classification has been proposed for half a century, but is still used worldwide. It shows many advantages of simple, easy handling with prognostic significance. The WHO classification scheme is better than Lauren classification in that it is continuously being revised according to the progress of gastric cancer, and is always used in the clinical and pathological diagnosis of common scenarios. Along with the progression of genomics, transcriptomics, proteomics, metabolomics researches, molecular classification of gastric cancer becomes the current hot topics. The traditional therapeutic approach based on phenotypic characteristics of gastric cancer will most likely be replaced with a gene variation mode. The gene-targeted therapy against the same molecular variation seems more reasonable than traditional chemical treatment based on the same morphological change.
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Radtke, Christine; Wewetzer, Konstantin
2009-06-12
Olfactory ensheathing cells (OECs) are Schwann cell-like glial cells of the olfactory system that have been shown to promote axonal regeneration and remyelination in a variety of different lesion paradigms. It is still a matter of debate in how far OECs differ from Schwann cells regarding their regenerative potential and molecular setup. The fact that OECs have been already used for transplantation in humans may imply that the need of the hour is the fine-tuning of clinical application details rather than to cross the bridge between laboratory animal and man. Considering the therapeutic transplantation of OECs, however, the basic question to date is not 'how' to translate but rather 'what' to translate into clinical practice. The aim of the present article is to provide a summary of the current literature and to define the open issues relevant for translating basic research on OECs into clinical practice.
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ERIC Educational Resources Information Center
Larusdottir, Steinunn Helga
2007-01-01
This article reports on the values and moral dilemmas of one Icelandic headteacher. The article draws on doctoral research currently being conducted with educational leaders in Icelandic basic schools. The research explores the values underpinning the work of female and male educational leaders and how values impact upon their actions, in…
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ERIC Educational Resources Information Center
McMiller, Tracee; Lee, Tameshia; Saroop, Ria; Green, Tyra; Johnson, Casonya M.
2006-01-01
We describe an eight-week summer Young Scientist in Training (YSIT) internship program involving middle and high school students. This program exposed students to current basic research in molecular genetics, while introducing or reinforcing principles of the scientific method and demonstrating the uses of mathematics and chemistry in biology. For…
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Summary of research in applied mathematics, numerical analysis, and computer sciences
NASA Technical Reports Server (NTRS)
1986-01-01
The major categories of current ICASE research programs addressed include: numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; control and parameter identification problems, with emphasis on effective numerical methods; computational problems in engineering and physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and computer systems and software, especially vector and parallel computers.
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JPRS Report, Science & Technology. Europe: Economic Competitiveness
1991-08-09
cost . Under the current funding scheme, support is only available through a system of reimbursable interest-free loans. With the currently proposed... system , basic indus- trial research will henceforth be financed by subsidies (of up to 50 percent of gross costs ). Small- and medium- sized...extremely cost -effective installations. • To market the MD110 as a foundation for office automation facilities. • To target very large system
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Patient-derived Xenograft (PDX) Models In Basic and Translational Breast Cancer Research
Dobrolecki, Lacey E.; Airhart, Susie D.; Alferez, Denis G.; Aparicio, Samuel; Behbod, Fariba; Bentires-Alj, Mohamed; Brisken, Cathrin; Bult, Carol J.; Cai, Shirong; Clarke, Robert B.; Dowst, Heidi; Ellis, Matthew J.; Gonzalez-Suarez, Eva; Iggo, Richard D.; Kabos, Peter; Li, Shunqiang; Lindeman, Geoffrey J.; Marangoni, Elisabetta; McCoy, Aaron; Meric-Bernstam, Funda; Piwnica-Worms, Helen; Poupon, Marie-France; Reis-Filho, Jorge; Sartorius, Carol A.; Scabia, Valentina; Sflomos, George; Tu, Yizheng; Vaillant, François; Visvader, Jane E.; Welm, Alana; Wicha, Max S.
2017-01-01
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational pre-clinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and “Triple-negative” (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward “credentialing” of PDX models as surrogates to represent individual patients for use in pre-clinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research. PMID:28025748
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ICASE semiannual report, April 1 - September 30, 1989
NASA Technical Reports Server (NTRS)
1990-01-01
The Institute conducts unclassified basic research in applied mathematics, numerical analysis, and computer science in order to extend and improve problem-solving capabilities in science and engineering, particularly in aeronautics and space. The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers. ICASE reports are considered to be primarily preprints of manuscripts that have been submitted to appropriate research journals or that are to appear in conference proceedings.
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NASA Technical Reports Server (NTRS)
Tishkoff, Julian M.; Drummond, J. Philip; Edwards, Tim; Nejad, Abdollah S.
1997-01-01
The Air Force Office of Scientific Research, the Air Force Wright Laboratory Aero Propulsion and Power Directorate, and the NASA Langley Research Center held a joint supersonic combustion workshop on 14-16 May 1996. The intent of this meeting was to: (1) examine the current state-of-the-art in hydrocarbon and/or hydrogen fueled scramjet research; (2) define the future direction and needs of basic research in support of scramjet technology; and (3) when appropriate, help transition basic research findings to solve the needs of developmental engineering programs in the area of supersonic combustion and fuels. A series of topical sessions were planned. Opening presentations were designed to focus and encourage group discussion and scientific exchange. The last half-day of the workshop was set aside for group discussion of the issues that were raised during the meeting for defining future research opportunities and directions. The following text attempts to summarize the discussions that took place at the workshop.
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Construction and Analysis of Electronic circuits
NASA Technical Reports Server (NTRS)
Thomas, Ashley N.
2004-01-01
The Aviation Environmental Technical Branch produces many various types of aeronautical research that benefits the NASA mission for space exploration and in turn, produces new technology for our nation. One of the present goals of the Aviation Environmental Technical Branch is to create better engines for airplanes by testing supersonic jet propulsion and safe fuel combustion. During the summer of 2004, I was hired by Vincent Sattenvhite Chief executive of the Aviation Environmental Technical Branch to Assist Yves Lamothe with a fuel igniter circuit. Yves Lamothe is an electrical engineer who is currently working on safe fuel combustion testing. This testing is planned to determine the minimum ignition energy for fuel and air vapors of current and alternative fuels under simulated flight conditions. An air temperature bath will provide simulated flight profile temperatures and the heat fluxes to the test chamber. I was assigned with Yves to help complete the igniter circuit which consists of a 36k voltage supply an oscilloscope, and a high voltage transistor switch. During my tenure in the L.E.C.I.R.P. program I studied the basics of electricity and circuitry along with two other projects that I completed. In the beginning of my internship, I devote all of my time to research the aspects of circuitry so that I would be prepared for the projects that I was assigned to do. I read about lessons on; the basic physical concepts of electronics, Electrical units, Basic dc circuits, direct current circuit analysis, resistance and cell batteries, various types of magnetism , Alternating current basics, inductance, and power supplies. I received work sheets and math equations from my Mentor so that I could be able to apply these concepts into my work. After I complete my studies, I went on to construct a LED chaser circuit which displays a series of light patterns using a 555 timer. I incorporated a switch and motion detector into the circuit to create basic alarm system. This project challenged my ability to interpret a schematic and expand it. While I was still completing the LED chaser circuit I Also was given A Basic Stamp Toddler Robot to build and program. The Toddler robot can walk in 36 various styles using advanced robotics. I used many different programs to create movement and direction of the robot. Also the Toddler can use infrared vision to sense objects. This enables the robot to maneuver indefinitely without running into objects. During my tenure at the NASA Glen Research Center I definite utilized the NASA mission to educate. I learned valuable information to help in my up coming year as a freshman in college.
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Developing a reliable signal wire attachment method for rail.
DOT National Transportation Integrated Search
2014-11-01
The goal of this project was to develop a better attachment method for rail signal wires to improve the reliability of signaling : systems. EWI conducted basic research into the failure mode of current attachment methods and developed and tested a ne...
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Practitioner Research Briefs, 1998-1999 Report Series.
ERIC Educational Resources Information Center
Virginia Adult Educators Research Network, Dayton.
The collection of articles addresses current issues in adult and adult basic education in Virginia communities. Titles include: "Goal-Setting in the New River Valley: Teachers' Perceptions and Strategies" (Sue Barton); "What Happens When ESL Students Experience Authentic Work Situations?" (Pat Bowyer); "Orientation to…
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Guidelines for traffic signal energy back-up systems : final report, August 2009.
DOT National Transportation Integrated Search
2009-07-01
Current practices of responding to power failures are very basic, ranging from 'do nothing' to installing portable generators. The purpose of this research project was to provide the NYSDOT with a better understand the practices of other agencies in ...
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Heijman, Jordi; Algalarrondo, Vincent; Voigt, Niels; Melka, Jonathan; Wehrens, Xander H T; Dobrev, Dobromir; Nattel, Stanley
2016-04-01
Atrial fibrillation (AF) is an extremely common clinical problem associated with increased morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation, and surgical therapies, and have significantly improved clinical outcomes. However, their efficacy remains suboptimal, and their use is limited by a variety of potentially serious adverse effects. There is a clear need for improved therapeutic options. Several decades of research have substantially expanded our understanding of the basic mechanisms of AF. Ectopic firing and re-entrant activity have been identified as the predominant mechanisms for arrhythmia initiation and maintenance. However, it has become clear that the clinical factors predisposing to AF and the cellular and molecular mechanisms involved are extremely complex. Moreover, all AF-promoting and maintaining mechanisms are dynamically regulated and subject to remodelling caused by both AF and cardiovascular disease. Accordingly, the initial presentation and clinical progression of AF patients are enormously heterogeneous. An understanding of arrhythmia mechanisms is widely assumed to be the basis of therapeutic innovation, but while this assumption seems self-evident, we are not aware of any papers that have critically examined the practical contributions of basic research into AF mechanisms to arrhythmia management. Here, we review recent insights into the basic mechanisms of AF, critically analyse the role of basic research insights in the development of presently used anti-AF therapeutic options and assess the potential value of contemporary experimental discoveries for future therapeutic innovation. Finally, we highlight some of the important challenges to the translation of basic science findings to clinical application. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.
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The Life Sciences program at the NASA Ames Research Center - An overview
NASA Technical Reports Server (NTRS)
Vernikos-Danellis, Joan; Sharp, Joseph C.
1989-01-01
The research projects planned for the Life Sciences program have a goal of answering basic questions concerning the nature of life itself and its evolution in the universe from basic elements, as well as the search for extraterrestrial intelligence. The program also includes studies of the evolution and development of life on the planet earth, and the global changes occurring today that affect life on the earth. The paper describes the simulation models developed to study the effects of space, the flight projects of the program, and the biomedical program, which currently focuses on the physiological changes in the human body that are associated with space flights and the interactions among these changes.
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View of Soviet ionospheric modification research
DOE Office of Scientific and Technical Information (OSTI.GOV)
Duncan, L.M.; Showen, R.L.
1990-10-01
We have reviewed and provided a technical assessment of Soviet research of the past five to ten years in ionospheric modification by high-power radio waves. This review includes a comprehensive survey of Soviet published literature, conference proceedings, and direct discussions with the involved Soviet researchers. The current state of the art for Soviet research in this field is evaluated, identifying areas of potential breakthrough discoveries, and discussing implications of this work for emerging technologies and future applications. This assessment is divided into the categories of basic research, advanced research, and applications. Basic research is further subdivided into studies of themore » modified natural geophysical environment, nonlinear plasma physics, and polar geophysical studies. Advanced research topics include the generation of artificial ionization mirrors and high-power oblique propagation effects. A separate comparative assessment of Soviet theoretical work also is included in this analysis. Our evaluation of practical and potential applications of this research discusses the utility of ionospheric modification in creating disturbed radio wave propagation environments, and its role in current and future remote-sensing and telecommunications systems. This technical assessment does not include consideration of ionospheric modification by means other than high-power radio waves. The Soviet effort in ionospheric modification sustains theoretical and experimental research at activity levels considerably greater than that found in comparable programs in the West. Notable strengths of the Soviet program are its breadth of coverage, large numbers of scientific participation, theoretical creativity and insight, and its powerful radio wave transmitting facilities.« less
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Cancer Treatment–Related Cardiotoxicity: Current State of Knowledge and Future Research Priorities
Adhikari, Bishow; Brell, Joanna; Davis, Myrtle; Desvigne-Nickens, Patrice; Freedman, Andrew; Minasian, Lori; Force, Thomas; Remick, Scot C.
2014-01-01
Cardiotoxicity resulting from direct myocyte damage has been a known complication of cancer treatment for decades. More recently, the emergence of hypertension as a clinically significant side effect of several new agents has been recognized as adversely affecting cancer treatment outcomes. With cancer patients living longer, in part because of treatment advances, these adverse events have become increasingly important to address. However, little is known about the cardiovascular pathogenic mechanisms associated with cancer treatment and even less about how to optimally prevent and manage short- and long-term cardiovascular complications, leading to improved patient safety and clinical outcomes. To identify research priorities, allocate resources, and establish infrastructure required to address cardiotoxicity associated with cancer treatment, the National Cancer Institute (NCI) and National Heart, Lung and Blood Institute (NHLBI) sponsored a two-day workshop, “Cancer treatment–related cardiotoxicity: Understanding the current state of knowledge and future research priorities,” in March 2013 in Bethesda, MD. Participants included leading oncology and cardiology researchers and health professionals, patient advocates and industry representatives, with expertise ranging from basic to clinical science. Attendees were charged with identifying research opportunities to advance the understanding of cancer treatment–related cardiotoxicity across basic and clinical science. This commentary highlights the key discussion points and overarching recommendations from that workshop. PMID:25210198
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The current deconstruction of paradoxes: one sign of the ongoing methodological "revolution".
Porta, Miquel; Vineis, Paolo; Bolúmar, Francisco
2015-10-01
The current deconstruction of paradoxes is one among several signs that a profound renewal of methods for clinical and epidemiological research is taking place; perhaps for some basic life sciences as well. The new methodological approaches have already deconstructed and explained long puzzling apparent paradoxes, including the (non-existent) benefits of obesity in diabetics, or of smoking in low birth weight. Achievements of the new methods also comprise the elucidation of the causal structure of long-disputed and highly complex questions, as Berkson's bias and Simpson's paradox, and clarifying reasons for deep controversies, as those on estrogens and endometrial cancer, or on adverse effects of hormone replacement therapy. These are signs that the new methods can go deeper and beyond the methods in current use. A major example of a highly relevant idea is: when we condition on a common effect of a pair of variables, then a spurious association between such pair is likely. The implications of these ideas are potentially vast. A substantial number of apparent paradoxes may simply be the result of collider biases, a source of selection bias that is common not just in epidemiologic research, but in many types of research in the health, life, and social sciences. The new approaches develop a new framework of concepts and methods, as collider, instrumental variables, d-separation, backdoor path and, notably, Directed Acyclic Graphs (DAGs). The current theoretical and methodological renewal-or, perhaps, "revolution"-may be changing deeply how clinical and epidemiological research is conceived and performed, how we assess the validity and relevance of findings, and how causal inferences are made. Clinical and basic researchers, among others, should get acquainted with DAGs and related concepts.
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[Basic research during residency in Israel: is change needed?].
Fishbain, Dana; Shoenfeld, Yehuda; Ashkenazi, Shai
2013-10-01
A six-month research period is a mandatory part of the residency training program in most basic specialties in Israel and is named: the "basic science period". This is the only period in an Israeli physician's medical career which is dedicated strictly to research, accentuating the importance of medical research to the quality of training and level of medicine in Israel. From another point of view, one may argue that in an era of shortage of physicians on the one hand and the dizzying rate of growth in medical knowledge on the other hand, every moment spent training in residency is precious, therefore, making the decision of whether to dedicate six months for research becomes ever more relevant. This question is currently raised for discussion once again by the Scientific Council of the Israeli Medical Association. The Scientific Council lately issued a call for comments sent to all Israeli physicians, asking their opinion on several key questions regarding basic science research. Learning the public's opinion will serve as a background for discussion. A total of 380 physicians responded to the call and specified their standpoint on the subject, among them heads of departments, units and clinics, senior physicians and residents. The findings pointed to strong support in maintaining the research period as part of residency training due to its importance to medical training and medicine, although half the respondents supported the use of various alternative formats for research together with the existing format. Those alternative format suggestions will be thoroughly reviewed. A smaller group of respondents supported allowing residents a choice between two tracks--with or without a research period, and only a few were in favor of canceling the research requirement altogether. The writers maintain that the "basic science period" of research during residency training is vital and its contribution to the high level of specialists and high level of medicine requires its conservation. Nevertheless, alternative formats which might be suitable for some residents should be considered, and auxiliary tools to help residents fulfill their potential in research and raise the quality of written research papers should be constructed.
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The national labs and their future
DOE Office of Scientific and Technical Information (OSTI.GOV)
Crease, R.P.
National laboratories of the USA, born with the atomic age and raised to prominence by the need for scientific superiority during the long Cold War, are facing the most critical challenge: how best to support the nation's current need to improve its international competitiveness through superior technology The charge that the national laboratories are [open quotes]Cold War relics[close quotes] that have outlived their usefulness is based on a misunderstanding of their mission, says Robert P. Crease, historian for Brookhaven National laboratory. Three of the labs-Los Alamos, Sandia, and Lawrence Livermore- are weapons laboratories and their missions must change. Oak Ridge,more » Argonne, and Brookhaven laboratories are multipurpose: basic research facilities with a continuing role in the world of science The national laboratory system traces its origins to the Manhattan Project. Over the next half-century, America's national labs grew into part of the most effective scientific establishment in the world, a much-copied model for management of large-scale scientific programs. In the early years, each lab defined a niche in the complex world of reactors, accelerators, and high-energy proton and electron physics. In the 1970s, several labs worked on basic energy sciences to help solve a national energy crisis. Today, the labs are pressured to do more applied research-research to transfer to the private sector and will have to respond by devising more effective ways of coordinating basic and applied research. But, Crease warns, [open quotes]It also will be essential that any commitment to applied research not take place at the cost of reducing the wellspring of basic research from which so much applied research flows. [open quotes]Making a solid and persuasive case for the independent value of basic research, and for their own role in that enterprise, may be the most important task facing the laboratories in their next half-century,[close quotes].« less
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Research progress on laser crystals in China
NASA Astrophysics Data System (ADS)
Yingxia, Z.
1985-01-01
Current Chinese research on laser crystals is now quite extensive and involves more than 30 research teams with nearly 1,000 technicians and workers actively engaged in the study of more than 20 types of laser cyrstals. Neodymium-doped yttrium aluminum garnet (Nd:YAG) and ruby (Cr:Al2O3) lasers have been manufactured and are widely employed. There are several new and promising crystals now under study which will find applications, and both basic and exploratory research have given rise to new developments.
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Environmental health discipline science plan
NASA Technical Reports Server (NTRS)
1991-01-01
The purpose of this plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in environmental health. It covers the significant research areas critical to NASA's programmatic requirements for the Extended Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; animal and human subjects; and research and development. This document summarizes the history and current status of the program elements, outlines available knowledge, establishes goals and objectives, identifies scientific priorities, and defines critical questions in the three disciplines: (1) Barophysiology, (2) Toxicology, and (3) Microbiology. This document contains a general plan that will be used by both NASA Headquarters Program Officers and the field centers to review and plan basic, applied, and operational research and development activities, both intramural and extramural, in this area. The document is divided into sections addressing these three disciplines.
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Basic and applied research related to the technology of space energy conversion systems, 1982 - 1983
NASA Technical Reports Server (NTRS)
Hertzberg, A.
1983-01-01
Topics on solar energy conversion concepts and applications are discussed. An overview of the current status and future utilization of radiation receivers for electrical energy generation, liquid droplet radiation systems, and liquid droplet heat exchangers is presented.
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Cell Therapy for Lung Diseases. Report from an NIH–NHLBI Workshop, November 13–14, 2012
Matthay, Michael A.; Anversa, Piero; Bhattacharya, Jahar; Burnett, Bruce K.; Chapman, Harold A.; Hare, Joshua M.; Hei, Derek J.; Hoffman, Andrew M.; Kourembanas, Stella; McKenna, David H.; Ortiz, Luis A.; Ott, Harald C.; Tente, William; Thébaud, Bernard; Trapnell, Bruce C.; Weiss, Daniel J.; Yuan, Jason X.-J.
2013-01-01
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened the Cell Therapy for Lung Disease Working Group on November 13–14, 2012, to review and formulate recommendations for future research directions. The workshop brought together investigators studying basic mechanisms and the roles of cell therapy in preclinical models of lung injury and pulmonary vascular disease, with clinical trial experts in cell therapy for cardiovascular diseases and experts from the NHLBI Production Assistance for Cell Therapy program. The purpose of the workshop was to discuss the current status of basic investigations in lung cell therapy, to identify some of the scientific gaps in current knowledge regarding the potential roles and mechanisms of cell therapy in the treatment of lung diseases, and to develop recommendations to the NHLBI and the research community on scientific priorities and practical steps that would lead to first-in-human trials of lung cell therapy. PMID:23713908
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Basic aerodynamic research facility for comparative studies of flow diagnostic techniques
NASA Technical Reports Server (NTRS)
Jones, Gregory S.; Gartrell, Luther R.; Stainback, P. Calvin
1987-01-01
Current flow diagnostic research efforts are focusing on higher order flow field data bases, such as those generated by laser velocimetry (LV), hot-wire anemometry, and multi-hole pressure probes. Recent low-speed comparisons of results obtained with LV and hot wires have revealed strengths and weaknesses of each instrument. A seeding study will be initiated to determine particulate tracking ability.
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ERIC Educational Resources Information Center
Rupp, Andre A.
2007-01-01
One of the most revolutionary advances in psychometric research during the last decades has been the systematic development of statistical models that allow for cognitive psychometric research (CPR) to be conducted. Many of the models currently available for such purposes are extensions of basic latent variable models in item response theory…
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An overview of cancer research in South African academic and research institutions, 2013 - 2014.
Moodley, Jennifer; Stefan, D Cristina; Sewram, Vikash; Ruff, Paul; Freeman, Melvyn; Asante-Shongwe, Kwanele
2016-05-10
Cancer is emerging as a critical public health problem in South Africa (SA). Recognising the importance of research in addressing the cancer burden, the Ministerial Advisory Committee on the Prevention and Control of Cancer (MACC) research working group undertook a review of the current cancer research landscape in SA and related this to the cancer burden. Academic and research institutions in SA were contacted to provide information on the titles of all current and recently completed (2013/2014) cancer research projects. Three MACC research working group members used the project titles to independently classify the projects by type of research (basic, clinical and public health - projects could be classified in more than one category) and disease site. A more detailed classification of projects addressing the five most common cancers diagnosed in males and females in SA was conducted using an adapted Common Scientific Outline (CSO) categorisation. Information was available on 556 cancer research projects. Overall, 301 projects were classified as clinical, 254 as basic science and 71 as public health research. The most common cancers being researched were cancers of the breast (n=95 projects) and cervix (n=43), leukaemia (n=36), non-Hodgkin's lymphoma (n=35) and lung cancer (n=23). Classification of the five most common cancers in males and females in SA, using the adapted CSO categories, showed that the majority of projects related to treatment, with relatively few projects on prevention, survivorship and patient perspectives. Our findings established that there is a dearth of public health cancer research in SA.
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Integrated fundamental research on current collection
NASA Astrophysics Data System (ADS)
Kuhlmann-Wilsdorf, Doris; Tran, Leo
1993-06-01
The aim of our research was to add to the basic understanding in the area of current collection with particular emphasis on topics likely to benefit practical objectives. Under sponsorship of this contract, 23 papers were published in the international literature. Additionally, 13 invited lectures and 11 contributed lectures on various aspects of this research were delivered at universities, research laboratories, and international conferences by the principal investigator and co-workers. The development of a novel metal fiber material for sliding electrical contacts was continued with much success. This is expected to become very useful for making metal fiber brushed for homopolar motors/generators, as well as for EML armatures. Included in this report are title pages (and abstracts) for the 23 published papers.
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Communicating the Value of Science--Issues, Imperatives and Insights
NASA Astrophysics Data System (ADS)
Gan, J.; Topousis, D.
2013-12-01
Over the last six decades, federal investments in scientific research have led to unquestionable economic and societal advances, while expanding human knowledge. Yet, in the current federal fiscal climate, funding for fundamental research is being challenged in some quarters. This situation has created the need for stakeholders in science to step forward and defend the role that basic research plays in creating the knowledge and workforce necessary to address current and future challenges. Communicating to fellow scientists in this environment is necessary but not sufficient to sustaining, or even expanding, support for fundamental research. A multi-faceted approach will be described for enhancing communication to broader audiences, including policy makers and the general public, increasingly responsible for ensuring the future of scientific progress.
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State-Building: Job Creation, Investment Promotion, and the Provision of Basic Services
2010-09-01
gap between what practitioners need to know and what research can currently show with reasonable confidence. There is a further wide gap between what...IRAs), which selectively rehired staff and paid higher wages in return for monitored performance. There may be scope for research on whether vari...rehired staff and paid higher wages in return for monitored performance. There may be scope for research on whether vari- ations in the costs of tax
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ESN (European Science Notes) Information Bulletin Reports on Current European/Middle Eastern Science
1988-10-01
about 35 institutes. tion method for technical alcohol, a modified upflow The quality of research carried out at the various fermenter was constructed in...developed for research with this fermenter whereby suc- application. It is beyond the scope of this report to de- rose, glucose, fructose, and...that lactobacilli in Food Research. Among the important aspects of the di- foods such as yogurt , cheese, sausage, and sauerkraut vision’s work on basic
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SOME CURRENT PROBLEMS IN SECOND-LANGUAGE TEACHING.
ERIC Educational Resources Information Center
WARDHAUGH, RONALD
ALTHOUGH THE LINGUISTS, PSYCHOLOGISTS, AND TEACHERS WHO HAVE STRESSED THE HABITUAL ASPECTS OF LANGUAGE HAVE MADE MANY USEFUL CONTRIBUTIONS TO LINGUISTIC RESEARCH AND LANGUAGE TEACHING, THERE STILL REMAIN SOME BASIC PROBLEMS. WITH THE PSYCHOLOGIST, PEDAGOGUE, SOCIOLOGIST, AND ANTHROPOLOGIST, THE LINGUIST MUST ATTACK THE GROUP OF PROBLEMS ASSOCIATED…
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Rare isotope accelerator project in Korea and its application to high energy density sciences
NASA Astrophysics Data System (ADS)
Chung, M.; Chung, Y. S.; Kim, S. K.; Lee, B. J.; Hoffmann, D. H. H.
2014-01-01
As a national science project, the Korean government has recently established the Institute for Basic Science (IBS) with the goal of conducting world-class research in basic sciences. One of the core facilities for the IBS will be the rare isotope accelerator which can produce high-intensity rare isotope beams to investigate the fundamental properties of nature, and also to support a broad research program in material sciences, medical and biosciences, and future nuclear energy technologies. The construction of the accelerator is scheduled to be completed by approximately 2017. The design of the accelerator complex is optimized to deliver high average beam current on targets, and to maximize the production of rare isotope beams through the simultaneous use of Isotope Separation On-Line (ISOL) and In-Flight Fragmentation (IFF) methods. The proposed accelerator is, however, not optimal for high energy density science, which usually requires very high peak currents on the target. In this study, we present possible beam-plasma experiments that can be done within the scope of the current accelerator design, and we also investigate possible future extension paths that may enable high energy density science with intense pulsed heavy ion beams.
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A tutorial on information retrieval: basic terms and concepts
Zhou, Wei; Smalheiser, Neil R; Yu, Clement
2006-01-01
This informal tutorial is intended for investigators and students who would like to understand the workings of information retrieval systems, including the most frequently used search engines: PubMed and Google. Having a basic knowledge of the terms and concepts of information retrieval should improve the efficiency and productivity of searches. As well, this knowledge is needed in order to follow current research efforts in biomedical information retrieval and text mining that are developing new systems not only for finding documents on a given topic, but extracting and integrating knowledge across documents. PMID:16722601
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Defining a global research agenda for breast cancer
Love, Richard R.
2008-01-01
In contrast to western high income nations, the incidence and mortality from breast cancer are increasing in most low and middle income countries worldwide. Current approaches to breast cancer control developed for populations of high income societies should not be directly transferred without evaluation. A relevant research agenda includes population differences in tumor biology and metabolization of systemic therapies; cultural and psychosocial issues; and operations in health care systems. Highest priority should be given to assessments of clinical downstaging and basic systemic treatment effectiveness in low and middle income populations. Partnerships of existing organizations in high income nations with those in low and middle income countries are currently the most feasible sources of research support. PMID:18837032
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Management of Anterior Cruciate Ligament Injury: What's In and What's Out?
Raines, Benjamin Todd; Naclerio, Emily; Sherman, Seth L
2017-01-01
Sports medicine physicians have a keen clinical and research interest in the anterior cruciate ligament (ACL). The biomechanical, biologic, and clinical data researchers generate, help drive injury management and prevention practices globally. The current concepts in ACL injury and surgery are being shaped by technological advances, expansion in basic science research, resurging interest in ACL preservation, and expanding efforts regarding injury prevention. As new methods are being developed in this field, the primary goal of safely improving patient outcomes will be a unifying principle. With this review, we provide an overview of topics currently in controversy or debate, and we identify paradigm shifts in the understanding, management, and prevention of ACL tears. PMID:28966380
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Back to the Basics: Cnidarians Start to Fire.
Bosch, Thomas C G; Klimovich, Alexander; Domazet-Lošo, Tomislav; Gründer, Stefan; Holstein, Thomas W; Jékely, Gáspár; Miller, David J; Murillo-Rincon, Andrea P; Rentzsch, Fabian; Richards, Gemma S; Schröder, Katja; Technau, Ulrich; Yuste, Rafael
2017-02-01
The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to reveal fundamental principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of cnidarian species and propose that researchers should seize this opportunity and undertake the study of members of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Future directions in the use of dental implants.
Bloem, T J
1989-10-01
Future development in implant prosthodontics should be based on the fundamentals of sound research and reliable clinical implementation. The goals should be to research the safety and efficacy of implants with regard to materials, host receptor site and interfacial zone; to develop acceptable uniform standards of evaluation; and to submit findings to scientific methods of analysis in determining benefit-to-risk factors. This presentation will offer a glimpse at some current developments in basic and clinical research focusing on studies in biocompatability and host acceptance; the implant-tissue interface; processes in osteogenesis related to vascularization of host sites; and bioengineering studies related to stress analysis and dimensional accuracy of impression systems for implants. The presentation will further describe future direction in research, training and implementation of services through development of an interdisciplinary team. A center is proposed to address the need for combined efforts in clinical and basic science research, the broad scope of implant utilization, and the teaching of implant procedures within an academic setting and to our colleagues.
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Making Basic Science Studies in Glaucoma More Clinically Relevant: The Need for a Consensus.
Toris, Carol B; Gelfman, Claire; Whitlock, Andy; Sponsel, William E; Rowe-Rendleman, Cheryl L
2017-09-01
Glaucoma is a chronic, progressive, and debilitating optic neuropathy that causes retinal damage and visual defects. The pathophysiologic mechanisms of glaucoma remain ill-defined, and there is an indisputable need for contributions from basic science researchers in defining pathways for translational research. However, glaucoma researchers today face significant challenges due to the lack of a map of integrated pathways from bench to bedside and the lack of consensus statements to guide in choosing the right research questions, techniques, and model systems. Here, we present the case for the development of such maps and consensus statements, which are critical for faster development of the most efficacious glaucoma therapy. We underscore that interrogating the preclinical path of both successful and unsuccessful clinical programs is essential to defining future research. One aspect of this is evaluation of available preclinical research tools. To begin this process, we highlight the utility of currently available animal models for glaucoma and emphasize that there is a particular need for models of glaucoma with normal intraocular pressure. In addition, we outline a series of discoveries from cell-based, animal, and translational research that begin to reveal a map of glaucoma from cell biology to physiology to disease pathology. Completion of these maps requires input and consensus from the global glaucoma research community. This article sets the stage by outlining various approaches to such a consensus. Together, these efforts will help accelerate basic science research, leading to discoveries with significant clinical impact for people with glaucoma.
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Basic Science for a Secure Energy Future
NASA Astrophysics Data System (ADS)
Horton, Linda
2010-03-01
Anticipating a doubling in the world's energy use by the year 2050 coupled with an increasing focus on clean energy technologies, there is a national imperative for new energy technologies and improved energy efficiency. The Department of Energy's Office of Basic Energy Sciences (BES) supports fundamental research that provides the foundations for new energy technologies and supports DOE missions in energy, environment, and national security. The research crosses the full spectrum of materials and chemical sciences, as well as aspects of biosciences and geosciences, with a focus on understanding, predicting, and ultimately controlling matter and energy at electronic, atomic, and molecular levels. In addition, BES is the home for national user facilities for x-ray, neutron, nanoscale sciences, and electron beam characterization that serve over 10,000 users annually. To provide a strategic focus for these programs, BES has held a series of ``Basic Research Needs'' workshops on a number of energy topics over the past 6 years. These workshops have defined a number of research priorities in areas related to renewable, fossil, and nuclear energy -- as well as cross-cutting scientific grand challenges. These directions have helped to define the research for the recently established Energy Frontier Research Centers (EFRCs) and are foundational for the newly announced Energy Innovation Hubs. This overview will review the current BES research portfolio, including the EFRCs and user facilities, will highlight past research that has had an impact on energy technologies, and will discuss future directions as defined through the BES workshops and research opportunities.
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Adolescents' Use of Basic, Intermediate, and Advanced Device Types for Vaping.
Pepper, Jessica K; MacMonegle, Anna J; Nonnemaker, James M
2017-12-23
Advanced models of electronic vaping products (EVPs) likely pose a greater risk to adolescent health than basic or intermediate models because advanced models deliver nicotine more effectively and heat e-liquid to higher temperatures, producing more harmful chemical emissions. However, little is known about adolescents' risk factors for using different device types. We used social media to recruit an online sample of 1,508 U.S. adolescents aged 15-17 who reported past 30-day use of e-cigarettes. We assessed tobacco use, beliefs and knowledge about EVPs, and EVP use behavior, including the device type participants use most frequently. We used multinomial logistic regression to examine differences between adolescents who usually use intermediate versus basic and advanced versus basic devices. Most respondents usually used modifiable advanced devices (56.8%) rather than basic "cigalike" (14.5%) or pen-style intermediate (28.7%) devices. Use of multiple device types was common, particularly among those who primarily used basic devices. Younger age and less frequent vaping were associated with mainly using basic devices. Adolescents who were older, male, personally bought their main device, and had ever mixed e-liquids were at elevated risk for usually using advanced devices. Adolescents who primarily use basic devices may be newer users who are experimenting with multiple devices. Future research should examine which adolescents are most likely to transition to advanced devices in order to develop targeted interventions. Regulators should consider strategies to reduce access to all types of EVPs, such as better enforcement of the current ban on sales to minors. This research addresses two gaps in research on adolescent electronic vaping product use: (1) characterizing use of advanced devices as distinct from intermediate devices rather than grouping them together and (2) examining factors associated with use of specific device types. This study suggests that there are distinct profiles of adolescents who use primarily basic, intermediate, or advanced devices. Adolescents who most often use basic devices may be new users experimenting with vaping, whereas adolescents who most often use advanced devices appear to be buying devices for themselves and engaging in risky behaviors such as mixing their own e-liquid. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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Periprosthetic Joint Infections: Clinical and Bench Research
Legout, Laurence; Senneville, Eric
2013-01-01
Prosthetic joint infection is a devastating complication with high morbidity and substantial cost. The incidence is low but probably underestimated. Despite a significant basic and clinical research in this field, many questions concerning the definition of prosthetic infection as well the diagnosis and the management of these infections remained unanswered. We review the current literature about the new diagnostic methods, the management and the prevention of prosthetic joint infections. PMID:24288493
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Fukatsu, Takema; Kuratani, Shigeru
2016-02-01
A new open-access journal, Zoological Letters, was launched as a sister journal to Zoological Science, in January 2015. The new journal aims at publishing topical papers of high quality from a wide range of basic zoological research fields. This review highlights the notable reviews and research articles that have been published in the first year of Zoological Letters, providing an overview on the current achievements and future directions of the journal.
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Integration of basic sciences and clinical sciences in oral radiology education for dental students.
Baghdady, Mariam T; Carnahan, Heather; Lam, Ernest W N; Woods, Nicole N
2013-06-01
Educational research suggests that cognitive processing in diagnostic radiology requires a solid foundation in the basic sciences and knowledge of the radiological changes associated with disease. Although it is generally assumed that dental students must acquire both sets of knowledge, little is known about the most effective way to teach them. Currently, the basic and clinical sciences are taught separately. This study was conducted to compare the diagnostic accuracy of students when taught basic sciences segregated or integrated with clinical features. Predoctoral dental students (n=51) were taught four confusable intrabony abnormalities using basic science descriptions integrated with the radiographic features or taught segregated from the radiographic features. The students were tested with diagnostic images, and memory tests were performed immediately after learning and one week later. On immediate and delayed testing, participants in the integrated basic science group outperformed those from the segregated group. A main effect of learning condition was found to be significant (p<0.05). The results of this study support the critical role of integrating biomedical knowledge in diagnostic radiology and shows that teaching basic sciences integrated with clinical features produces higher diagnostic accuracy in novices than teaching basic sciences segregated from clinical features.
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Public's Knowledge of Science and Technology
ERIC Educational Resources Information Center
Pew Research Center, 2013
2013-01-01
The public's knowledge of science and technology varies widely across a range of questions on current topics and basic scientific concepts, according to a new quiz by the Pew Research Center and "Smithsonian" magazine. About eight-in-ten Americans (83%) identify ultraviolet as the type of radiation that sunscreen protects against. Nearly…
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European Science Notes Information Bulletin Reports on Current European and Middle Eastern Science
1993-10-01
yielding sulfate and zation of such construction and similar waste mate- salts. These inorganics are difficult to treat in rials. Basic pavement...to humans. This research 10 shampooings could remove the drug. Although showed no correlation to the amounts of cocaine Dr. Cone had dissolved hair
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Centers and Institutes for the "Resource-Challenged" Catholic University
ERIC Educational Resources Information Center
Sanders, Susan M.; Clough, Joy
2011-01-01
Founded in 2001, the Center for Religion and Public Discourse at Saint Xavier University, Chicago, illustrates how centers and institutes can express Catholic identity and serve the university community and society by providing opportunities for thoughtful and civil discourse. Although the Center does not currently support basic research or fund…
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The Classical Performing Arts of India.
ERIC Educational Resources Information Center
Curtiss, Marie Joy
A monograph of the numerous activities that have contributed to the current renaissance of India's classical performing arts covers the theoretical aspects, musical instruments, the main schools of classical dance, and drama. Besides the basic research described, the total project produced a set of 300 slides with annotated listing, picturing the…
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Advancing high-speed rail policy in the United States [research brief].
DOT National Transportation Integrated Search
2012-06-01
This report investigates the current state of high-speed rail (HSR) policy in the US, juxtaposing it against HSR experience in Asia and Europe. The purpose is to identify basic steps that must be put in place if a HSR system is to be developed in the...
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Proceedings of the Eighth International Workshop on Advances in Electrocorticography
Ritaccio, Anthony L.; Williams, Justin; Denison, Tim; Foster, Brett L.; Starr, Philip A.; Gunduz, Aysegul; Zijlmans, Maeike; Schalk, Gerwin
2017-01-01
Excerpted proceedings of The Eighth International Workshop on Advances in Electrocorticography (ECoG), which convened October 15–16, 2015 in Chicago, IL, are presented. The workshop series has become the foremost gathering to present current basic and clinical research in subdural brain signal recording and analysis. PMID:27780085
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The Wisdom of Scientific Inquiry on Education
ERIC Educational Resources Information Center
Glass, Gene V.
1972-01-01
Under current conditions evaluative research based on curriculum products of master teachers using basic knowledge from the social and natural sciences is more likely to contribute to the improvement of educational practice than is an attempt to build theories of teaching based upon rapidly changing philosophy and technique. (AL)
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Green Roofs: A Part of Green Infrastructure Strategy for Urban Areas
This is a presentation on the basics of green roof technology. The presentation highlights some of the recent ORD research projects on green roofs and provides insight for the end user as to the benefits for green roof technology. It provides links to currently available EPA rep...
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Understanding the Integral: Students' Symbolic Forms
ERIC Educational Resources Information Center
Jones, Steven R.
2013-01-01
Researchers are currently investigating how calculus students understand the basic concepts of first-year calculus, including the integral. However, much is still unknown regarding the "cognitive resources" (i.e., stable cognitive units that can be accessed by an individual) that students hold and draw on when thinking about the integral. This…
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Introductory Programming Subject in European Higher Education
ERIC Educational Resources Information Center
Aleksic, Veljko; Ivanovic, Mirjana
2016-01-01
Programming is one of the basic subjects in most informatics, computer science mathematics and technical faculties' curricula. Integrated overview of the models for teaching programming, problems in teaching and suggested solutions were presented in this paper. Research covered current state of 1019 programming subjects in 715 study programmes at…
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Children and Adolescents: Should We Teach Them or Let Them Learn?
ERIC Educational Resources Information Center
Rohwer, William D., Jr.
Research to date has provided too few answers for vital educational questions concerning teaching children or letting them learn. A basic problem is that experimentation usually begins by accepting conventional assumptions about schooling, ignoring experiments that would entail disturbing the ordering of current educational priorities.…
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The molecular biology of soft-tissue sarcomas and current trends in therapy.
Quesada, Jorge; Amato, Robert
2012-01-01
Basic research in sarcoma models has been fundamental in the discovery of scientific milestones leading to a better understanding of the molecular biology of cancer. Yet, clinical research in sarcoma has lagged behind other cancers because of the multiple clinical and pathological entities that characterize sarcomas and their rarity. Sarcomas encompass a very heterogeneous group of tumors with diverse pathological and clinical overlapping characteristics. Molecular testing has been fundamental in the identification and better definition of more specific entities among this vast array of malignancies. A group of sarcomas are distinguished by specific molecular aberrations such as somatic mutations, intergene deletions, gene amplifications, reciprocal translocations, and complex karyotypes. These and other discoveries have led to a better understanding of the growth signals and the molecular pathways involved in the development of these tumors. These findings are leading to treatment strategies currently under intense investigation. Disruption of the growth signals is being targeted with antagonistic antibodies, tyrosine kinase inhibitors, and inhibitors of several downstream molecules in diverse molecular pathways. Preliminary clinical trials, supported by solid basic research and strong preclinical evidence, promises a new era in the clinical management of these broad spectrum of malignant tumors.
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Gravitational biology on the space station
NASA Technical Reports Server (NTRS)
Keefe, J. R.; Krikorian, A. D.
1983-01-01
The current status of gravitational biology is summarized, future areas of required basic research in earth-based and spaceflight projects are presented, and potential applications of gravitational biology on a space station are demonstrated. Topics covered include vertebrate reproduction, prenatal/postnatal development, a review of plant space experiments, the facilities needed for growing plants, gravimorphogenesis, thigmomorphogenesis, centrifuges, maintaining a vivarium, tissue culture, and artificial human organ generation. It is proposed that space stations carrying out these types of long-term research be called the National Space Research Facility.
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Sadler, Euan; Fisher, Helen R.; Maher, John; Wolfe, Charles D. A.; McKevitt, Christopher
2016-01-01
Introduction Translational research is central to international health policy, research and funding initiatives. Despite increasing use of the term, the translation of basic science discoveries into clinical practice is not straightforward. This systematic search and narrative synthesis aimed to examine factors enabling or hindering translational research from the perspective of basic and clinician scientists, a key stakeholder group in translational research, and to draw policy-relevant implications for organisations seeking to optimise translational research opportunities. Methods and Results We searched SCOPUS and Web of Science from inception until April 2015 for papers reporting scientists’ views of the factors they perceive as enabling or hindering the conduct of translational research. We screened 8,295 papers from electronic database searches and 20 papers from hand searches and citation tracking, identifying 26 studies of qualitative, quantitative or mixed method designs. We used a narrative synthesis approach and identified the following themes: 1) differing concepts of translational research 2) research processes as a barrier to translational research; 3) perceived cultural divide between research and clinical care; 4) interdisciplinary collaboration as enabling translation research, but dependent on the quality of prior and current social relationships; 5) translational research as entrepreneurial science. Across all five themes, factors enabling or hindering translational research were largely shaped by wider social, organisational, and structural factors. Conclusion To optimise translational research, policy could consider refining translational research models to better reflect scientists’ experiences, fostering greater collaboration and buy in from all types of scientists. Organisations could foster cultural change, ensuring that organisational practices and systems keep pace with the change in knowledge production brought about by the translational research agenda. PMID:27490373
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Fudge, Nina; Sadler, Euan; Fisher, Helen R; Maher, John; Wolfe, Charles D A; McKevitt, Christopher
2016-01-01
Translational research is central to international health policy, research and funding initiatives. Despite increasing use of the term, the translation of basic science discoveries into clinical practice is not straightforward. This systematic search and narrative synthesis aimed to examine factors enabling or hindering translational research from the perspective of basic and clinician scientists, a key stakeholder group in translational research, and to draw policy-relevant implications for organisations seeking to optimise translational research opportunities. We searched SCOPUS and Web of Science from inception until April 2015 for papers reporting scientists' views of the factors they perceive as enabling or hindering the conduct of translational research. We screened 8,295 papers from electronic database searches and 20 papers from hand searches and citation tracking, identifying 26 studies of qualitative, quantitative or mixed method designs. We used a narrative synthesis approach and identified the following themes: 1) differing concepts of translational research 2) research processes as a barrier to translational research; 3) perceived cultural divide between research and clinical care; 4) interdisciplinary collaboration as enabling translation research, but dependent on the quality of prior and current social relationships; 5) translational research as entrepreneurial science. Across all five themes, factors enabling or hindering translational research were largely shaped by wider social, organisational, and structural factors. To optimise translational research, policy could consider refining translational research models to better reflect scientists' experiences, fostering greater collaboration and buy in from all types of scientists. Organisations could foster cultural change, ensuring that organisational practices and systems keep pace with the change in knowledge production brought about by the translational research agenda.
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Basic science breaks through: New therapeutic advances in Parkinson's disease.
Brundin, Patrik; Atkin, Graham; Lamberts, Jennifer T
2015-09-15
Parkinson's disease (PD) is the second most common neurodegenerative disease and is typically associated with progressive motor dysfunction, although PD patients also exhibit a variety of non-motor symptoms. The neuropathological hallmark of PD is intraneuronal inclusions containing primarily α-Synuclein (α-Syn), and several lines of evidence point to α-Syn as a key contributor to disease progression. Thus, basic research in the field of PD is largely focused on understanding the pathogenic properties of α-Syn. Over the past 2 y, these studies helped to identify several novel therapeutic strategies that have the potential to slow PD progression; such strategies include sequestration of extracellular α-Syn through immunotherapy, reduction of α-Syn multimerization or intracellular toxicity, and attenuation of the neuroinflammatory response. This review describes these and other putative therapeutic strategies, together with the basic science research that led to their identification. The current breadth of novel targets for the treatment of PD warrants cautious optimism in the fight against this devastating disease. © 2015 International Parkinson and Movement Disorder Society.
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Estimating the NIH Efficient Frontier
2012-01-01
Background The National Institutes of Health (NIH) is among the world’s largest investors in biomedical research, with a mandate to: “…lengthen life, and reduce the burdens of illness and disability.” Its funding decisions have been criticized as insufficiently focused on disease burden. We hypothesize that modern portfolio theory can create a closer link between basic research and outcome, and offer insight into basic-science related improvements in public health. We propose portfolio theory as a systematic framework for making biomedical funding allocation decisions–one that is directly tied to the risk/reward trade-off of burden-of-disease outcomes. Methods and Findings Using data from 1965 to 2007, we provide estimates of the NIH “efficient frontier”, the set of funding allocations across 7 groups of disease-oriented NIH institutes that yield the greatest expected return on investment for a given level of risk, where return on investment is measured by subsequent impact on U.S. years of life lost (YLL). The results suggest that NIH may be actively managing its research risk, given that the volatility of its current allocation is 17% less than that of an equal-allocation portfolio with similar expected returns. The estimated efficient frontier suggests that further improvements in expected return (89% to 119% vs. current) or reduction in risk (22% to 35% vs. current) are available holding risk or expected return, respectively, constant, and that 28% to 89% greater decrease in average years-of-life-lost per unit risk may be achievable. However, these results also reflect the imprecision of YLL as a measure of disease burden, the noisy statistical link between basic research and YLL, and other known limitations of portfolio theory itself. Conclusions Our analysis is intended to serve as a proof-of-concept and starting point for applying quantitative methods to allocating biomedical research funding that are objective, systematic, transparent, repeatable, and expressly designed to reduce the burden of disease. By approaching funding decisions in a more analytical fashion, it may be possible to improve their ultimate outcomes while reducing unintended consequences. PMID:22567087
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Hayes Lane, Susan; Serafica, Reimund; Huffman, Carolyn; Cuddy, Alyssa
2016-01-01
In the current healthcare environment, nurses must have a basic understanding of research to lead change and implement evidence-based practice. The purpose of this study was to evaluate the effectiveness of an educational intervention formulated on the framework of the Great American Cookie Experiment measuring nurses' research knowledge, attitudes, and practice using mobile device gaming. This multisite quantitative study provides insight into promotion of research and information about best practices on innovative teaching strategies for nurses.
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32 CFR 272.3 - Definition of basic research.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 32 National Defense 2 2014-07-01 2014-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...
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32 CFR 272.3 - Definition of basic research.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 32 National Defense 2 2012-07-01 2012-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...
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Nondestructive Testing Eddy Current Basic Principles RQA/M1-5330.12 (V-I).
ERIC Educational Resources Information Center
National Aeronautics and Space Administration, Huntsville, AL. George C. Marshall Space Flight Center.
As one in the series of programmed instruction handbooks, prepared by the U.S. space program, home study material is presented in this volume concerning familiarization and orientation on basic eddy current principles. The subject is presented under the following headings: Basic Eddy Current Concepts, Eddy Current Generation and Distribution,…
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NASA Technical Reports Server (NTRS)
Engelund, Walter C.; Holland, Scott D.; Cockrell, Charles E., Jr.; Bittner, Robert D.
1999-01-01
NASA's Hyper-X Research Vehicle will provide a unique opportunity to obtain data on an operational airframe integrated scramjet propulsion system at true flight conditions. The airframe integrated nature of the scramjet engine with the Hyper-X vehicle results in a strong coupling effect between the propulsion system operation and the airframe s basic aerodynamic characteristics. Comments on general airframe integrated scramjet propulsion system effects on vehicle aerodynamic performance, stability, and control are provided, followed by examples specific to the Hyper-X research vehicle. An overview is provided of the current activities associated with the development of the Hyper-X aerodynamic database, including wind tunnel test activities and parallel CFD analysis efforts. A brief summary of the Hyper-X aerodynamic characteristics is provided, including the direct and indirect effects of the airframe integrated scramjet propulsion system operation on the basic airframe stability and control characteristics.
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Fidler, Sarah; Thornhill, John; Malatinkova, Eva; Reinhard, Robert; Lamplough, Rosanne; Ananworanich, Jintanat; Chahroudi, Ann
2015-10-01
The International AIDS Society (IAS) convened the Towards an HIV Cure Symposium on 18-19 July 2015 in Vancouver, Canada, bringing together researchers and community to discuss the most recent advances in our understanding of HIV latency, reservoirs and a summary of the current clinical approaches towards an HIV cure. The symposium objectives were to: (1) gather researchers and stakeholders to present, review, and discuss the latest research towards an HIV cure; (2) promote cross-disciplinary global interactions between basic, clinical and social scientists; and (3) provide a platform for sharing information among scientists, clinicians, funders, media and civil society. The symposium examined basic molecular science and animal model data, and emerging and ongoing clinical trial results to prioritise strategies and determine the viral and immune responses that could lead to HIV remission without antiretroviral therapy. This report summarises some of the major findings discussed during the symposium.
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Replacement bearing for Rocketdyne SSME HPOTPs using alternate self-lubricating retainer materials
NASA Technical Reports Server (NTRS)
Gleeson, J.; Dufrane, K.; Kannel, J.
1992-01-01
Research was conducted to develop replacement bearings for the Rocketdyne Space Shuttle main engine (SSME) high pressure oxidizer turbopumps (HPOTPs). The replacement bearings consisted of standard balls and races with a special Battelle Self-Lubricating Insert Configuration (BASIC) retainer. The BASIC retainer consists of a phosphor bronze housing with inserts consisting of a polytetrafluoretheylene (PTFE) and bronze compound. The PTFE contacts the balls and the land guiding surface on the outer race. A PTFE transfer film is formed on balls and races, which lubricates the critical interfaces. The BASIC retainer is a one-to-one replacement for the current Armalon retainer, but has superior lubricating properties and is stronger over the broad temperature range anticipated for the HPOTP bearings. As a part of the project 40 sets of balls and races (two sizes) and 52 BASIC retainers were shipped to NASA/MSFC.
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NASA Astrophysics Data System (ADS)
Uhlenbrock, K.; Landau, E. A.; Hankin, E. R.
2013-12-01
Federally funded scientific research is one of the building blocks of technological advancement and economic growth. This research can also lead to transformational ideas and discoveries. In our current fiscal environment, strategies to rein in federal spending have become a priority, although they have proven to be complex. The possible deals and negotiations to reduce federal spending may hinder the work of the scientific community to serve society. Since 2005 federal investment in research and development has slowed. The average annual growth in federal funding for scientific research from 2004 - 2009 was 0.9% as compared to 3.3% over the previous 20 years. What does the current budget situation mean for science? It means reductions in basic and applied research, interruptions in long-term monitoring and data collection, an inability to repair or build infrastructure, and less federal grant support for current and future scientists. I will first provide an update on the current federal budget situation and examples of how current policies are impacting the scientific community. Second, I will present a case study of the effect of reduced federal investment in science. Specifically, I will discuss how investments in research and development have far-reaching impacts on society and examine how reduced funding impairs valuable research efforts.
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The NASA Materials Science Research Program - It's New Strategic Goals and Plans
NASA Technical Reports Server (NTRS)
Schlagheck, Ronald A.
2003-01-01
In 2001, the NASA created a separate science enterprise, the Office of Biological and Physical Research (OBPR), to perform strategical and fundamental research bringing together physics, chemistry, biology, and engineering to solve problems needed for future agency mission goals. The Materials Science Program is one of basic research disciplines within this new Enterprise's Division of Physical Sciences Research. The Materials Science Program participates to utilize effective use of International Space Station (ISS) experimental facilities, target new scientific and technology questions, and transfer results for Earth benefits. The program has recently pursued new investigative research in areas necessary to expand NASA knowledge base for exploration of the universe, some of which will need access to the microgravity of space. The program has a wide variety of traditional ground and flight based research related types of basic science related to materials crystallization, fundamental processing, and properties characterization in order to obtain basic understanding of various phenomena effects and relationships to the structures, processing, and properties of materials. A summary of the types and sources for this research is presented and those experiments planned for the space. Areas to help expand the science basis for NASA future missions are described. An overview of the program is given including the scope of the current and future NASA Research Announcements with emphasis on new materials science initiatives. A description of the planned flight experiments to be conducted on the International Space Station program along with the planned facility class Materials Science Research Rack (MSRR) and Microgravity Glovebox (MSG) type investigations.
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Semiannual report, 1 April - 30 September 1991
NASA Technical Reports Server (NTRS)
1991-01-01
The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software for parallel computers. Research in these areas is discussed.
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Cigarette smoking. Health effects and cessation strategies.
Sachs, D P
1986-05-01
During the last 15 years substantial advances in the fields of analytical chemistry, behavioral pharmacology, neurologic sciences, and the behavioral sciences have produced new understanding and insight into why people smoke and how they can stop. These fundamental research efforts have now produced treatment strategies that have objectively documented success rates and that the physician can now implement in his office. Impressive as current results can be, when the physician is willing to spend appropriate and necessary time, effort, and energy, current research indicates that our basic neurochemical understanding of cigarette smoking should improve substantially and lead to even more effective treatment interventions in the next 10 years.
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Rich-Edwards, Janet W; Kaiser, Ursula B; Chen, Grace L; Manson, JoAnn E; Goldstein, Jill
2018-04-12
A sex and gender-informed perspective increases rigor, promotes discovery, and expands the relevance of biomedical research. In the current era of accountability to present data for males and females, thoughtful and deliberate methodology can improve study design and inference in sex and gender differences research. We address issues of motivation, subject selection, sample size, data collection, analysis, and interpretation, considering implications for basic, clinical, and population research. In particular, we focus on methods to test sex/gender differences as effect modification or interaction, and discuss why some inferences from sex-stratified data should be viewed with caution. Without careful methodology, the pursuit of sex difference research, despite a mandate from funding agencies, will result in a literature of contradiction. However, given the historic lack of attention to sex differences, the absence of evidence for sex differences is not necessarily evidence of the absence of sex differences. Thoughtfully conceived and conducted sex and gender differences research is needed to drive scientific and therapeutic discovery for all sexes and genders.
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Teaching ethical aptitude to graduate student researchers.
Weyrich, Laura S; Harvill, Eric T
2013-01-01
Limited time dedicated to each training areas, irrelevant case-studies, and ethics "checklists" have resulted in bare-bones Responsible Conduct of Research (RCR) training for present biomedical graduate student researchers. Here, we argue that science graduate students be taught classical ethical theory, such as virtue ethics, consequentialist theory, and deontological theory, to provide a basic framework to guide researchers through ethically complex situations and examine the applicability, implications, and societal ramifications of their research. Using a relevant biomedical research example to illustrate this point, we argue that proper ethics training for graduate student researchers not only will enhance current RCR training, but train more creative, responsible scientists.
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Gene Silencing in Crustaceans: From Basic Research to Biotechnologies
Sagi, Amir; Manor, Rivka; Ventura, Tomer
2013-01-01
Gene silencing through RNA interference (RNAi) is gaining momentum for crustaceans, both in basic research and for commercial development. RNAi has proven instrumental in a growing number of crustacean species, revealing the functionality of novel crustacean genes essential among others to development, growth, metabolism and reproduction. Extensive studies have also been done on silencing of viral transcripts in crustaceans, contributing to the understanding of the defense mechanisms of crustaceans and strategies employed by viruses to overcome these. The first practical use of gene silencing in aquaculture industry has been recently achieved, through manipulation of a crustacean insulin-like androgenic gland hormone. This review summarizes the advancements in the use of RNAi in crustaceans, and assesses the advantages of this method, as well as the current hurdles that hinder its large-scale practice. PMID:24705266
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Moonshot Science-Risks and Benefits.
Casadevall, Arturo; Fang, Ferric C
2016-08-30
Ever since the successful Apollo 11 Moon landing in 1969, a "moonshot" has come to signify a bold effort to achieve a seemingly impossible task. The Obama administration recently called for a moonshot to cure cancer, an initiative that has elicited mixed responses from researchers who welcome additional funding but worry about raising expectations. We suggest that a successful moonshot requires a sufficient understanding of the basic science underlying a problem in question so that efforts can be focused on engineering a solution. Current gaps in our basic knowledge of cancer biology make the cancer moonshot a uniquely challenging endeavor. Nevertheless, history has shown that intensive research efforts have frequently yielded conceptual and technological breakthroughs with unanticipated benefits for society. We expect that this effort will be no different. Copyright © 2016 Casadevall and Fang.
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Yu, Helen W H
2016-02-01
The current drug discovery and development process is stalling the translation of basic science into lifesaving products. Known as the 'Valley of Death', the traditional technology transfer model fails to bridge the gap between early-stage discoveries and preclinical research to advance innovations beyond the discovery phase. In addition, the stigma associated with 'commercialization' detracts from the importance of efficient translation of basic research. Here, I introduce a drug discovery model whereby the respective expertise of academia and industry are brought together to take promising discoveries through to proof of concept as a way to derisk the drug discovery and development process. Known as the 'integrated drug discovery model', I examine here the extent to which existing legal frameworks support this model. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Spencer, Becky; Chacko, Jisha; Sallee, Donna
2011-06-01
The American Heart Association (AHA) has a strong commitment to implementing scientific research-based interventions for cardiopulmonary resuscitation and emergency cardiovascular care. This article presents the 2010 AHA major guideline changes to pediatric basic life support (BLS) and pediatric advanced life support (PALS) and the rationale for the changes. The following topics are covered in this article: (1) current understanding of cardiac arrest in the pediatric population, (2) major changes in pediatric BLS, and (3) major changes in PALS. Copyright © 2011. Published by Elsevier Inc.
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Beyond 100 Tesla: Scientific experiments using single-turn coils
NASA Astrophysics Data System (ADS)
Portugall, Oliver; Solane, Pierre Yves; Plochocka, Paulina; Maude, Duncan K.; Nicholas, Robin J.
2013-01-01
Current opportunities and recent examples for research in magnetic fields well above 100 T using single-turn coils are discussed. After a general introduction into basic principles and technical constraints associated with the generation of Megagauss fields we discuss data obtained at the LNCMI Toulouse, where such fields are routinely used for scientific applications.
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Teaching Food Preparation with Video Flash Cards
ERIC Educational Resources Information Center
Scholl, Jan F.; Cason, Katherine; Cherry, Tom
2004-01-01
Food preparation skills are needed to prepare low-cost, nutritious meals that meet current dietary recommendations. Research indicates that many youth and adults can read a recipe for ingredients, but they often do not know basic food preparation techniques such as how to broil, fold, dredge, baste and other cooking methods. To address the need to…
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Description of an Introductory Learning Strategies Course for the Job Skills Educational Program.
ERIC Educational Resources Information Center
Murphy, Debra Ann; Derry, Sharon J.
The Job Skills Educational Program (JSEP), currently under development for the Army Research Institute, embeds learner strategies training within the context of a basic skills computer-assisted instruction curriculum. The curriculum is designed for low-ability soldiers, and consists largely of instruction in the domain of intellectual skills. An…
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-05
... virtual instructor-led trainings on, for example, distance learning or the effective use of social media in a learning environment. This medium is also ideal for orientation, expectations, and other basics; (C) Reading assignments on current research; (D) Discussion forums, blogs, and/or social media...
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78 FR 34974 - Notice of Request for Extension of a Currently Approved Information Collection
Federal Register 2010, 2011, 2012, 2013, 2014
2013-06-11
... authorized in the Cooperative Marketing Act of 1926. DATES: Comments on this notice must be received by August 12, 2013. FOR FURTHER INFORMATION CONTACT: E. Eldon Eversull, Research and Education Division, RBS..., information, and education. The annual survey of farmer cooperatives collects basic statistics on cooperative...
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Using Spreadsheets in the Management, Analysis, and Reporting of Evaluation Data.
ERIC Educational Resources Information Center
Glowacki, Margaret L.; Rice, Richard L., Jr.
Currently available spreadsheet programs for microcomputers provide many features that can be very useful for evaluators and researchers. Some of the basic concepts involved in spreadsheet use are introduced, and information is provided on the use of spreadsheets in maintaining and analyzing evaluation data. The spreadsheet used in the discussion…
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Back to Basic: Aesthetic Experiences with Literature and Discovering the World
ERIC Educational Resources Information Center
Tice, Kathleen C.
2008-01-01
In this article, the author shares a current analysis of data that complements findings from earlier, related research that confirms the emotional aspects of reading experiences. The data from the earlier study is based upon comments by graduate students in online discussion groups, where they share their thoughts about the professional readings…
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Zoo and Wildlife Libraries: An International Survey
ERIC Educational Resources Information Center
Coates, Linda L.; Tierney, Kaitlyn Rose
2010-01-01
The conservation and well-being of exotic animals is core to the mission of zoos, aquariums and many small nonprofit wildlife groups. Increasingly, these organizations are committed to scientific research, both basic and applied. To ascertain the current state of the libraries that support their efforts, librarians at the San Diego Zoo conducted…
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"Getting Fit Basically Just Means, Like, Nonfat": Children's Lessons in Fitness and Fatness
ERIC Educational Resources Information Center
Powell, Darren; Fitzpatrick, Katie
2015-01-01
Current concerns about a childhood obesity crisis and children's physical activity levels have combined to justify fitness lessons as a physical education practice in New Zealand primary (elementary) schools. Researchers focused on children's understandings of fitness lessons argue that they construct fitness as a quest for an "ideal"…
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Principle Elements of Curriculum in the Preschool Pattern of Montessori
ERIC Educational Resources Information Center
Bahmaee, Azizollah Baboli; Saadatmand, Zohreh; Yarmohammadian, Mohammad Hossein
2016-01-01
Montessori the physician and educational philosopher was probably one of the most prominent and famous education theorizer in the field of preschool education. Current research attempts to extract and clarify the major elements of curriculum by reliance on Montessori viewpoints. In this paper first the philosophical basics of preschool education…
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Plastic Solar Cells: A Multidisciplinary Field to Construct Chemical Concepts from Current Research
ERIC Educational Resources Information Center
Gomez, Rafael; Segura, Jose L.
2007-01-01
Examples of plastic solar-cell technology to illustrate core concepts in chemistry are presented. The principles of operations of a plastic solar cell could be used to introduce key concepts, which are fundamentally important to understand photosynthesis and the basic process that govern most novel optoelectronic devices.
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Entrepreneurial Training Needs of Illiterate Women in Cross River State, Nigeria
ERIC Educational Resources Information Center
Ingwu, Emmanuel U.; Okey, Stella-Maris A.
2013-01-01
In order to improve on the curriculum and participation rate of adult learners in the current Adult Basic Education (ABE) program in Nigeria, this explorative study investigated the entrepreneurial (or vocational) training needs of illiterate women in Cross River State (CRS). Three research questions were posed to elicit from the participants…
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Flipped Classrooms and Student Learning: Not Just Surface Gains
ERIC Educational Resources Information Center
McLean, Sarah; Attardi, Stefanie M.; Faden, Lisa; Goldszmidt, Mark
2016-01-01
The flipped classroom is a relatively new approach to undergraduate teaching in science. This approach repurposes class time to focus on application and discussion; the acquisition of basic concepts and principles is done on the students' own time before class. While current flipped classroom research has focused on student preferences and…
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Fadare, Joseph O; Porteri, Corinna
2010-03-01
Informed consent is a basic requirement for the conduct of ethical research involving human subjects. Currently, the Helsinki Declaration of the World Medical Association and the International Ethical Guidelines for Biomedical Research of the Council for International Organizations of Medical Sciences (CIOMS) are widely accepted as international codes regulating human subject research and the informed consent sections of these documents are quite important. Debates on the applicability of these guidelines in different socio-cultural settings are ongoing and many workers have advocated the need for national or regional guidelines. Nigeria, a developing country, has recently adopted its national guideline regulating human subject research: the National Health Research Ethics Committee (NHREC) code. A content analysis of the three guidelines was done to see if the Nigerian guidelines confer any additional protection for research subjects. The concept of a Community Advisory Committee in the Nigerian guideline is a novel one that emphasizes research as a community burden and should promote a form of "research friendship" to foster the welfare of research participants. There is also the need for a regular update of the NHREC code so as to address some issues that were not considered in its current version.
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Young, Sera L; Mbuya, Mduduzi N N; Chantry, Caroline J; Geubbels, Eveline P; Israel-Ballard, Kiersten; Cohan, Deborah; Vosti, Stephen A; Latham, Michael C
2011-05-01
In 2008, between 129,000 and 194,000 of the 430,000 pediatric HIV infections worldwide were attributable to breastfeeding. Yet in many settings, the health, economic, and social consequences of not breastfeeding would have dire consequences for many more children. In the first part of this review we provide an overview of current knowledge about infant feeding in the context of HIV. Namely, we describe the benefits and risks of breastmilk, the evolution of recommended infant feeding modalities in high-income and low-income countries in the last two decades, and contextualize the recently revised guidelines for infant feeding in the context of HIV current knowledge. In the second section, we suggest areas for future research on the postnatal prevention of mother-to-child transmission of HIV (PMTCT) in developing and industrialized countries. We suggest two shifts in perspective. The first is to evaluate PMTCT interventions more holistically, to include the psychosocial and economic consequences as well as the biomedical ones. The second shift in perspective should be one that contextualizes postnatal PMTCT efforts in the cascade of maternal health services. We conclude by discussing basic, clinical, behavioral, and programmatic research questions pertaining to a number of PMTCT efforts, including extended postnatal ARV prophylaxis, exclusive breastfeeding promotion, counseling, breast milk pasteurization, breast milk banking, novel techniques for making breast milk safer, and optimal breastfeeding practices. We believe the research efforts outlined here will maximize the number of healthy, thriving, HIV-free children around the world.
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Young, Sera L.; Mbuya, Mduduzi N. N.; Chantry, Caroline J.; Geubbels, Eveline P.; Israel-Ballard, Kiersten; Cohan, Deborah; Vosti, Stephen A.; Latham, Michael C.
2011-01-01
In 2008, between 129,000 and 194,000 of the 430,000 pediatric HIV infections worldwide were attributable to breastfeeding. Yet in many settings, the health, economic, and social consequences of not breastfeeding would have dire consequences for many more children. In the first part of this review we provide an overview of current knowledge about infant feeding in the context of HIV. Namely, we describe the benefits and risks of breastmilk, the evolution of recommended infant feeding modalities in high-income and low-income countries in the last two decades, and contextualize the recently revised guidelines for infant feeding in the context of HIV current knowledge. In the second section, we suggest areas for future research on the postnatal prevention of mother-to-child transmission of HIV (PMTCT) in developing and industrialized countries. We suggest two shifts in perspective. The first is to evaluate PMTCT interventions more holistically, to include the psychosocial and economic consequences as well as the biomedical ones. The second shift in perspective should be one that contextualizes postnatal PMTCT efforts in the cascade of maternal health services. We conclude by discussing basic, clinical, behavioral, and programmatic research questions pertaining to a number of PMTCT efforts, including extended postnatal ARV prophylaxis, exclusive breastfeeding promotion, counseling, breast milk pasteurization, breast milk banking, novel techniques for making breast milk safer, and optimal breastfeeding practices. We believe the research efforts outlined here will maximize the number of healthy, thriving, HIV-free children around the world. PMID:22332055
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Current and experimental treatments of Parkinson disease: A guide for neuroscientists.
Oertel, Wolfgang; Schulz, Jörg B
2016-10-01
Over a period of more than 50 years, the symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been optimized using pharmacotherapy, deep brain stimulation, and physiotherapy. The arsenal of pharmacotherapies includes L-Dopa, several dopamine agonists, inhibitors of monoamine oxidase (MAO)-B and catechol-o-methyltransferase (COMT), and amantadine. In the later course of the disease, motor complications occur, at which stage different oral formulations of L-Dopa or dopamine agonists with long half-life, a transdermal application or parenteral pumps for continuous drug supply can be subscribed. Alternatively, the patient is offered deep brain stimulation of the subthalamic nucleus (STN) or the internal part of the globus pallidus (GPi). For a more efficacious treatment of motor complications, new formulations of L-Dopa, dopamine agonists, and amantadine as well as new MAO-B and COMT inhibitors are currently tested in clinical trials, and some of them already yielding positive results in phase 3 trials. In addition, non-dopaminergic agents have been tested in the early clinical phase for the treatment of motor fluctuations and dyskinesia, including adenosine A2A antagonists (istradefylline, preladenant, and tozadenant) and modulators of the metabolic glutamate receptor 5 (mGluR5 - mavoglurant) and serotonin (eltoprazine) receptors. Recent clinical trials testing coenzyme Q10, the dopamine agonist pramipexole, creatine monohydrate, pioglitazone, or AAV-mediated gene therapy aimed at increasing expression of neurturin, did not prove efficacious. Treatment with nicotine, caffeine, inosine (a precursor of urate), and isradipine (a dihydropyridine calcium channel blocker), as well as active and passive immunization against α-synuclein and inhibitors or modulators of α-synuclein-aggregation are currently studied in clinical trials. However, to date, no disease-modifying treatment is available. We here review the current status of treatment options for motor and non-motor symptoms, and discuss current investigative strategies for disease modification. This review provides basic insights, mainly addressing basic scientists and non-specialists. It stresses the need to intensify therapeutic PD research and points out reasons why the translation of basic research to disease-modifying therapies has been unsuccessful so far. The symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been constantly optimized using pharmacotherapy (L-Dopa, several dopamine agonists, inhibitors of monoamine oxidase (MAO)-B and catechol-o-methyltransferase (COMT), and amantadine), deep brain stimulation, and physiotherapy. For a more efficacious treatment of motor complications, new formulations of L-Dopa, dopamine agonists, and amantadine as well as new MAO-B and COMT inhibitors are currently tested in clinical trials. Non-dopaminergic agents have been tested in the early clinical phase for the treatment of motor fluctuations and dyskinesia. Recent clinical trials testing coenzyme Q10, the dopamine agonist pramipexole, creatine monohydrate, pioglitazone, or AAV-mediated gene therapy aimed at increasing expression of neurturin, did not prove efficacious. Treatment with nicotine, caffeine, and isradipine - a dihydropyridine calcium channel blocker - as well as active and passive immunization against α-synuclein and inhibitors of α-synuclein-aggregation are currently studied in clinical trials. However, to date, no disease-modifying treatment is available for PD. We here review the current status of treatment options and investigative strategies for both motor and non-motor symptoms. This review stresses the need to intensify therapeutic PD research and points out reasons why the translation of basic research to disease-modifying therapies has been unsuccessful so far. This article is part of a special issue on Parkinson disease. © 2016 International Society for Neurochemistry.
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Evaluating the ergonomics of BCI devices for research and experimentation.
Ekandem, Joshua I; Davis, Timothy A; Alvarez, Ignacio; James, Melva T; Gilbert, Juan E
2012-01-01
The use of brain computer interface (BCI) devices in research and applications has exploded in recent years. Applications such as lie detectors that use functional magnetic resonance imaging (fMRI) to video games controlled using electroencephalography (EEG) are currently in use. These developments, coupled with the emergence of inexpensive commercial BCI headsets, such as the Emotiv EPOC ( http://emotiv.com/index.php ) and the Neurosky MindWave, have also highlighted the need of performing basic ergonomics research since such devices have usability issues, such as comfort during prolonged use, and reduced performance for individuals with common physical attributes, such as long or coarse hair. This paper examines the feasibility of using consumer BCIs in scientific research. In particular, we compare user comfort, experiment preparation time, signal reliability and ease of use in light of individual differences among subjects for two commercially available hardware devices, the Emotiv EPOC and the Neurosky MindWave. Based on these results, we suggest some basic considerations for selecting a commercial BCI for research and experimentation. STATEMENT OF RELEVANCE: Despite increased usage, few studies have examined the usability of commercial BCI hardware. This study assesses usability and experimentation factors of two commercial BCI models, for the purpose of creating basic guidelines for increased usability. Finding that more sensors can be less comfortable and accurate than devices with fewer sensors.
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Endometriosis: Survey of Current Diagnostic and Therapeutic Options and Latest Research Work
Juhasz-Böss, I.; Laschke, M. W.; Müller, F.; Rosenbaum, P.; Baum, S.; Solomayer, E. F.; Ulrich, U.
2014-01-01
Endometriosis is one of the most frequent benign diseases in women of child-bearing age. The main symptoms are chronic upper abdominal pain and infertility. However, the aetiology and pathogenesis of endometriosis are as yet insufficiently clarified. Thus, therapy is mainly symptomatic with laparoscopic surgery being the gold standard. The aim of drug therapy is to achieve a hypo-oestrogenic condition. In cases of severe endometriosis and a desire to have children there is often an indication for assisted reproduction. The present article illustrates almost all current aspects on the diagnosis of and therapy of endometriosis. From the clinical viewpoint, emphasis is placed on the rare cases of deeply infiltrating endometriosis that are, however, accompanied with a high morbidity. Current therapeutic options in cases of infertility are also presented in more detail. Furthermore, special attention is paid to the latest research results from both clinical and basic research fields in order to demonstrate our current knowledge on the pathogenesis and, where possible, potentially related therapeutic options. PMID:25221341
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Rates and impact of trauma and current stressors among Darfuri refugees in Eastern Chad.
Rasmussen, Andrew; Nguyen, Leanh; Wilkinson, John; Vundla, Sikhumbuzo; Raghavan, Sumithra; Miller, Kenneth E; Keller, Allen S
2010-04-01
Darfur refugees face hardships associated with chronic displacement, including lack of basic needs and safety concerns. Psychiatric research on refugees has focused on trauma, but daily stressors may contribute more to variance in distress. This article reports rates of past trauma and current stressors among Darfur refugees and gauges the contribution of each to psychological distress and functional impairment. A representative sample of 848 Darfuris in 2 refugee camps were interviewed about traumatic events, stressors faced in the camps, psychological distress, and functional impairment. Basic needs and safety concerns were more strongly correlated with measures of distress (rs = .19-.31) than were war-related traumatic events (rs = .09-.20). Hierarchical regression supported models in which effects of trauma on distress were mediated by current stressors. Although war-related traumatic events are the initial causes of refugees' hardship, findings suggest that the day-to-day challenges and concerns in camps mediate psychological distress associated with these events.
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Rates and Impact of Trauma and Current Stressors Among Darfuri Refugees in Eastern Chad
Rasmussen, Andrew; Nguyen, Leanh; Wilkinson, John; Vundla, Sikhumbuzo; Raghavan, Sumithra; Miller, Kenneth E.; Keller, Allen S.
2010-01-01
Darfur refugees face hardships associated with chronic displacement, including lack of basic needs and safety concerns. Psychiatric research on refugees has focused on trauma, but daily stressors may contribute more to variance in distress. In this article we report rates of past trauma and current stressors among Darfur refugees and gauge the contribution of each to psychological distress and functional impairment. A representative sample of 848 Darfuris in two refugee camps were interviewed about traumatic events, stressors faced in the camps, psychological distress and functional impairment. Basic needs and safety concerns were more strongly correlated with measures of distress (r's = .19–.31) than were war-related traumatic events (r's = .09–.20). Hierarchical regression supported models in which effects of trauma on distress were mediated by current stressors. Although war-related traumatic events are the initial causes of refugees' hardship, findings suggest that the day-to-day challenges and concerns in camps mediate psychological distress associated with these events. PMID:20553516
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Chapman, C Richard; Vierck, Charles J
2017-04-01
The nature of the transition from acute to chronic pain still eludes explanation, but chronic pain resulting from surgery provides a natural experiment that invites clinical epidemiological investigation and basic scientific inquiry into the mechanisms of this transition. The primary purpose of this article is to review current knowledge and hypotheses on the transition from acute to persistent postsurgical pain, summarizing literature on clinical epidemiological studies of persistent postsurgical pain development, as well as basic neurophysiological studies targeting mechanisms in the periphery, spinal cord, and brain. The second purpose of this article is to integrate theory, information, and causal reasoning in these areas. Conceptual mapping reveals 5 classes of hypotheses pertaining to pain. These propose that chronic pain results from: 1) persistent noxious signaling in the periphery; 2) enduring maladaptive neuroplastic changes at the spinal dorsal horn and/or higher central nervous system structures reflecting a multiplicity of factors, including peripherally released neurotrophic factors and interactions between neurons and microglia; 3) compromised inhibitory modulation of noxious signaling in medullary-spinal pathways; 4) descending facilitatory modulation; and 5) maladaptive brain remodeling in function, structure, and connectivity. The third purpose of this article is to identify barriers to progress and review opportunities for advancing the field. This review reveals a need for a concerted, strategic effort toward integrating clinical epidemiology, basic science research, and current theory about pain mechanisms to hasten progress toward understanding, managing, and preventing persistent postsurgical pain. The development of chronic pain after surgery is a major clinical problem that provides an opportunity to study the transition from acute to chronic pain at epidemiologic and basic science levels. Strategic, coordinated, multidisciplinary research efforts targeting mechanisms of pain chronification can to help minimize or eliminate persistent postsurgical pain. Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.
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Advanced Bode Plot Techniques for Ultrasonic Transducers
NASA Astrophysics Data System (ADS)
DeAngelis, D. A.; Schulze, G. W.
The Bode plot, displayed as either impedance or admittance versus frequency, is the most basic test used by ultrasonic transducer designers. With simplicity and ease-of-use, Bode plots are ideal for baseline comparisons such as spacing of parasitic modes or impedance, but quite often the subtleties that manifest as poor process control are hard to interpret or are nonexistence. In-process testing of transducers is time consuming for quantifying statistical aberrations, and assessments made indirectly via the workpiece are difficult. This research investigates the use of advanced Bode plot techniques to compare ultrasonic transducers with known "good" and known "bad" process performance, with the goal of a-priori process assessment. These advanced techniques expand from the basic constant voltage versus frequency sweep to include constant current and constant velocity interrogated locally on transducer or tool; they also include up and down directional frequency sweeps to quantify hysteresis effects like jumping and dropping phenomena. The investigation focuses solely on the common PZT8 piezoelectric material used with welding transducers for semiconductor wire bonding. Several metrics are investigated such as impedance, displacement/current gain, velocity/current gain, displacement/voltage gain and velocity/voltage gain. The experimental and theoretical research methods include Bode plots, admittance loops, laser vibrometry and coupled-field finite element analysis.
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Impact of Hearing Aid Technology on Outcomes in Daily Life I: the Patients’ Perspective
Cox, Robyn M; Johnson, Jani A; Xu, Jingjing
2016-01-01
Objectives One of the challenges facing hearing care providers when recommending hearing aids is the choice of device technology level. Major manufacturers market families of hearing aids that are described as spanning the range from basic technology to premium technology. Premium technology hearing aids include acoustical processing capabilities (features) that are not found in basic technology instruments. These premium features are intended to yield improved hearing in daily life compared to basic-feature devices. However, independent research that establishes the incremental effectiveness of premium-feature devices compared to basic-feature devices is lacking. This research was designed to explore reported differences in hearing abilities for adults using premium-feature and basic-feature hearing aids in their daily lives. Design This was a single-blinded, repeated, crossover trial in which the participants were blinded. All procedures were carefully controlled to limit researcher bias. Forty-five participants used carefully fitted bilateral hearing aids for one month and then provided data to describe the hearing improvements or deficiencies noted in daily life. Typical participants were 70 years old with mild to moderate adult-onset hearing loss bilaterally. Each participant used 4 pairs of hearing aids: premium- and basic-feature devices from brands marketed by each of two major manufacturers. Participants were blinded about the devices they used and about the research questions. Results All of the outcomes were designed to capture the participant’s point of view about the benefits of the hearing aids. Three types of data were collected: change in hearing-related quality of life, extent of agreement with six positively worded statements about everyday hearing with the hearing aids, and reported preferences between the premium- and basic-feature devices from each brand as well as across all four research hearing aids combined. None of these measures yielded a statistically significant difference in outcomes between premium- and basic-feature devices. Participants did not report better outcomes with premium processing with any measure. Conclusions It could reasonably be asserted that the patient’s perspective is the gold standard for hearing aid effectiveness. While the acoustical processing provided by premium features can potentially improve scores on tests conducted in contrived conditions in a laboratory, or on specific items in a questionnaire, this does not ensure that the processing will be of noteworthy benefit when the hearing aid is used in the real world challenges faced by the patient. If evidence suggests the patient cannot detect that premium features yield improvements over basic features in daily life, what is the responsibility of the provider in recommending hearing aid technology level? In the current research, there was no evidence to suggest that premium-feature devices yielded better outcomes than basic-feature devices from the patient’s point of view. All of the research hearing aids were substantially, but equally, helpful. Further research is needed on this topic with other hearing aids and other manufacturers. In the meantime, providers should insist on scientifically credible independent evidence to support effectiveness claims for any hearing help devices. PMID:26881981
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NASA Technical Reports Server (NTRS)
Suit, W. T.; Batterson, J. G.
1986-01-01
The aerodynamics of the basic F-106B were determined at selected points in the flight envelope. The test aircraft and flight procedures were presented. Aircraft instrumentation and the data system were discussed. The parameter extraction procedure was presented along with a discussion of the test flight results. The results were used to predict the aircraft motions for maneuvers that were not used to determine the vehicle aerodynamics. The control inputs used to maneuver the aircraft to get data for the determination of the aerodynamic parameters were discussed in the flight test procedures. The results from the current flight tests were compared with the results from wind tunnel test of the basic F-106B.
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32 CFR Appendix A to Part 272 - Principles for the Conduct and Support of Basic Research
Code of Federal Regulations, 2010 CFR
2010-07-01
... Research A Appendix A to Part 272 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE... Research 1. Basic research is an investment. The DoD Components are to view and manage basic research...
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Research activities at the Loma Linda University and Proton Treatment Facility--an overview
NASA Technical Reports Server (NTRS)
Nelson, G. A.; Green, L. M.; Gridley, D. S.; Archambeau, J. O.; Slater, J. M.
2001-01-01
The Loma Linda University (LLU) Radiobiology Program coordinates basic research and proton beam service activities for the university and extramural communities. The current focus of the program is on the biological and physical properties of protons and the operation of radiobiology facilities for NASA-sponsored projects. The current accelerator, supporting facilities and operations are described along with a brief review of extramural research projects supported by the program. These include space craft electronic parts and shielding testing as well as tumorigenesis and animal behavior experiments. An overview of research projects currently underway at LLU is also described. These include: 1) acute responses of the C57Bl/6 mouse immune system, 2) modulation of gene expression in the nematode C. elegans and rat thyroid cells, 3) quantitation of dose tolerance in rat CNS microvasculature, 4) behavioral screening of whole body proton and iron ion-irradiated C57Bl/6 mice, and 5) investigation of the role of cell integration into epithelial structures on responses to radiation.
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A Research Agenda to Underpin Malaria Eradication
Alonso, Pedro L.; Brown, Graham; Arevalo-Herrera, Myriam; Binka, Fred; Chitnis, Chetan; Collins, Frank; Doumbo, Ogobara K.; Greenwood, Brian; Hall, B. Fenton; Levine, Myron M.; Mendis, Kamini; Newman, Robert D.; Plowe, Christopher V.; Rodríguez, Mario Henry; Sinden, Robert; Slutsker, Laurence; Tanner, Marcel
2011-01-01
The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scaling up control with currently available tools and strategies, much greater gains could be achieved against malaria, including elimination from a number of countries and regions; however, even with maximal effort we will fall short of global eradication. The Malaria Eradication Research Agenda (malERA) complements the current research agenda—primarily directed towards reducing morbidity and mortality—with one that aims to identify key knowledge gaps and define the strategies and tools that will result in reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders, and the scientific community, together with a massive effort to build a strong base of researchers from the endemic areas will be critical factors in the success of this new agenda. PMID:21311579
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Review of spectral imaging technology in biomedical engineering: achievements and challenges.
Li, Qingli; He, Xiaofu; Wang, Yiting; Liu, Hongying; Xu, Dongrong; Guo, Fangmin
2013-10-01
Spectral imaging is a technology that integrates conventional imaging and spectroscopy to get both spatial and spectral information from an object. Although this technology was originally developed for remote sensing, it has been extended to the biomedical engineering field as a powerful analytical tool for biological and biomedical research. This review introduces the basics of spectral imaging, imaging methods, current equipment, and recent advances in biomedical applications. The performance and analytical capabilities of spectral imaging systems for biological and biomedical imaging are discussed. In particular, the current achievements and limitations of this technology in biomedical engineering are presented. The benefits and development trends of biomedical spectral imaging are highlighted to provide the reader with an insight into the current technological advances and its potential for biomedical research.
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Yang, Huiping; Tiersch, Terrence R.
2009-01-01
Aquarium fishes are becoming increasingly important because of their value in biomedical research and the ornamental fish trade, and because many have become threatened or endangered in the wild. This review summarizes the current status of sperm cryopreservation in three fishes widely used in biomedical research: zebrafish, medaka, and live-bearing fishes of the genus Xiphophorus, and will focus on the needs and opportunities for future research and application of cryopreservation in aquarium fish. First, we summarize the basic biological characteristics regarding natural habitat, testis structure, spermatogenesis, sperm morphology, and sperm physiology. Second, we compare protocol development of sperm cryopreservation. Third, we emphasize the importance of artificial fertilization in sperm cryopreservation to evaluate the viability of thawed sperm. We conclude with a look to future research directions for sperm cryopreservation and the application of this technique in aquarium species. PMID:18691673
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NASA Astrophysics Data System (ADS)
Hock, Emily; Sharp, Zoe
2016-03-01
Aspiring teachers and current teachers can gain insight about the scientific community through hands-on experience. As America's standards for elementary school and middle school become more advanced, future and current teachers must gain hands-on experience in the scientific community. For a teacher to be fully capable of teaching all subjects, they must be comfortable in the content areas, equipped to answer questions, and able to pass on their knowledge. Hands-on research experiences, like the Summer Astronomy Research Experience at California Polytechnic University, pair liberal studies students with a cooperative group of science students and instructors with the goal of doing research that benefits the scientific community and deepens the team members' perception of the scientific community. Teachers are then able to apply the basic research process in their classrooms, inspire students to do real life science, and understand the processes scientists' undergo in their workplace.
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Nanotechnology in food processing sector-An assessment of emerging trends.
Kalpana Sastry, R; Anshul, Shrivastava; Rao, N H
2013-10-01
Use of nanoscience based technology in the food industry is fast emerging as new area for research and development. Several research groups including private companies in the industry have initiated research programmes for exploring the wide scope of nanotechnology into the value chain of food processing and manufacturing. This paper discusses the current focus of research in this area and assesses its potential impacts. Using the developed relational database framework with R&D indicators like literature and patent documents for assessment of the potential of nanotechnology in food sector, a model to organize and map nanoresearch areas to the food processing sector was developed. The study indicates that the about five basic categories of nanotechnology applications and functionalities currently in the development of food sector, include food processing, packaging, nutraceuticals delivery, food safety and functional foods.
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Advanced liner-cooling techniques for gas turbine combustors
NASA Technical Reports Server (NTRS)
Norgren, C. T.; Riddlebaugh, S. M.
1985-01-01
Component research for advanced small gas turbine engines is currently underway at the NASA Lewis Research Center. As part of this program, a basic reverse-flow combustor geometry was being maintained while different advanced liner wall cooling techniques were investigated. Performance and liner cooling effectiveness of the experimental combustor configuration featuring counter-flow film-cooled panels is presented and compared with two previously reported combustors featuring: splash film-cooled liner walls; and transpiration cooled liner walls (Lamilloy).
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NORSAR Basic Seismological Research
1992-11-29
addressee is no longer employed by your organization, please notify PL/TSI, Hanscom AF3 MA 01731-3010. This will assist us in maintaining a current mailing...distribution unlimited 13. ABSTRACT (Maximum 200 words) This Final Report describes the work accomplished under Cont-ract No . F49620-C-89- 0038...I D ’t A IiYS MjQA~ Pre face Under contract No . F49620-C-89-0038, NTNF/NORSAR has been conducting research within a wide range of subjects relevant to
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Structural dynamics and control of large space structures. [conference
NASA Technical Reports Server (NTRS)
Lightner, E. B. (Compiler)
1981-01-01
The focus of the workshop was the basic research program assembled by LaRC to address the fundamental technology deficiencies that were identified in several studies on large space systems (LSS) conducted by NASA in the last several years. The staffs of the respective participants were assembled at the workshop to review the current state of research in the control technology for large structural systems and to plan the efforts that would be pursued by their respective organizations.
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Nation-wide primary healthcare research network: a privacy protection assessment.
De Clercq, Etienne; Van Casteren, Viviane; Bossuyt, Nathalie; Moreels, Sarah; Goderis, Geert; Bartholomeeusen, Stefaan; Bonte, Pierre; Bangels, Marc
2012-01-01
Efficiency and privacy protection are essential when setting up nationwide research networks. This paper investigates the extent to which basic services developed to support the provision of care can be re-used, whilst preserving an acceptable privacy protection level, within a large Belgian primary care research network. The generic sustainable confidentiality management model used to assess the privacy protection level of the selected network architecture is described. A short analysis of the current architecture is provided. Our generic model could also be used in other countries.
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Dey, Moul
2014-01-01
Advances in “omics”-based fields have produced an explosion of new information, fueling high expectations for improved public and individualized health. Unfortunately, there exists a widening gap between basic biochemistry and “omics”-based population research, with both disciplines failing to translate their full potential impact to human health applications. A paucity of comprehensive study systems is one of the many roadblocks faced by translational research today. This commentary will highlight the current status of such research, particularly emphasizing the role of nutrigenomics. PMID:25364700
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Progress of research of high-Tc superconductors
NASA Technical Reports Server (NTRS)
Tanaka, Shoji
1991-01-01
Research in the area of of high T(sub c) superconductors has made great progress in the last few years. New materials were found and the systematic investigation of these materials has contributed to understanding the mechanism of high T(sub c) superconductivity. The critical currents in thin films, bulks, and tapes increased drastically, and the origin of flux pinning will be clarified in the near future. The future of high T(sub c) superconductivity, in both the basic and applied research areas, is very optimistic. Recent activities in research of high T(sub c) superconductivity and superconductors in Japan are overviewed.
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Photovoltaic Research in the Small Business Innovative Research Program
NASA Astrophysics Data System (ADS)
Bower, Ward I.; Bulawka, Alec
1997-02-01
The Small Business Innovative Research Program (SBIR) is currently authorized to be funded through September 30, 2000. The National Photovoltaics Program is a contributor to the Department of Energy (DOE) SBIR program. The small business photovoltaic industry has been benefiting from the SBIR program through awards that have funded basic research, new processes and products that have PV and other commercial applications. This paper provides information on SBIR opportunities, selected details of the SBIR program, statistics from the 1995 and 1996 DOE SBIR program, and methods for improving PV industry participation and success in the SBIR program.
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[Basic science and applied science].
Pérez-Tamayo, R
2001-01-01
A lecture was presented by the author at the Democratic Opinion Forum on Health Teaching and Research, organized by Mexico's National Health Institutes Coordinating Office, at National Cardiology Institute "Ignacio Chavez", where he presented a critical review of the conventional classification of basic and applied science, as well as his personal view on health science teaching and research. According to the author, "well-conducted science" is that "generating reality-checked knowledge" and "mis-conducted science" is that "unproductive or producing 'just lies' and 'non-fundable'. To support his views, the author reviews utilitarian and pejorative definitions of science, as well as those of committed and pure science, useful and useless science, and practical and esoterical science, as synonyms of applied and basic science. He also asserts that, in Mexico, "this classification has been used in the past to justify federal funding cutbacks to basic science, allegedly because it is not targeted at solving 'national problems' or because it was not relevant to priorities set in a given six-year political administration period". Regarding health education and research, the author asserts that the current academic programs are inefficient and ineffective; his proposal to tackle these problems is to carry out a solid scientific study, conducted by a multidisciplinary team of experts, "to design the scientific researcher curricula from recruitment of intelligent young people to retirement or death". Performance assessment of researchers would not be restricted to publication of papers, since "the quality of scientific work and contribution to the development of science is not reflected by the number of published papers". The English version of this paper is available at: http://www.insp.mx/salud/index.html
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Reporting Experiments in Homeopathic Basic Research (REHBaR).
Stock-Schröer, Beate
2015-10-01
The aim of this study was to develop a criteria catalogue serving as a guideline for authors to improve quality of Reporting Experiments in Homeopathic Basic Research (REHBaR). Main focus was in the field of biochemical and biological experiments. So far, there was no guideline for scientists and authors available, unlike criteria catalogues common in clinical research. A Delphi Process was conducted among experts who published experimental work within the last five years in this field. The process included a total of five rounds, three rounds of adjusting and phrasing plus two consensus conferences. A checklist of 23 items was achieved, augmented with detailed examples how to handle each item while compiling a publication. Background, objectives and possible hypotheses are necessary to be given in the part 'introduction'. The section 'materials and methods' is the most important part, where a detailed description of chosen controls, object of investigation, experimental setup, replication, parameters, intervention, allocation, blinding, and statistical methods is mandatory. In the 'results' section sufficient details on analysed data, descriptive as well as inferential are needed. Moreover, authors should discuss their results and interpret them in the context of current evidence. REHBaR was compiled for authors when preparing their manuscripts, and to be used by scientific journals in the reviewing process. Reporting experiments in basic research in homeopathy is an important issue to state the quality and validity of gained results. A guideline for REHBaR seemed to be the first step to come to a commitment what information is necessary to be given in a paper. More than that, the catalogue can serve as a statement what the standards in good basic research should be. Copyright © 2015 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.
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Informatics Support for Basic Research in Biomedicine
Rindflesch, Thomas C.; Blake, Catherine L.; Fiszman, Marcelo; Kilicoglu, Halil; Rosemblat, Graciela; Schneider, Jodi; Zeiss, Caroline J.
2017-01-01
Abstract Informatics methodologies exploit computer-assisted techniques to help biomedical researchers manage large amounts of information. In this paper, we focus on the biomedical research literature (MEDLINE). We first provide an overview of some text mining techniques that offer assistance in research by identifying biomedical entities (e.g., genes, substances, and diseases) and relations between them in text. We then discuss Semantic MEDLINE, an application that integrates PubMed document retrieval, concept and relation identification, and visualization, thus enabling a user to explore concepts and relations from within a set of retrieved citations. Semantic MEDLINE provides a roadmap through content and helps users discern patterns in large numbers of retrieved citations. We illustrate its use with an informatics method we call “discovery browsing,” which provides a principled way of navigating through selected aspects of some biomedical research area. The method supports an iterative process that accommodates learning and hypothesis formation in which a user is provided with high level connections before delving into details. As a use case, we examine current developments in basic research on mechanisms of Alzheimer’s disease. Out of the nearly 90 000 citations returned by the PubMed query “Alzheimer’s disease,” discovery browsing led us to 73 citations on sortilin and that disorder. We provide a synopsis of the basic research reported in 15 of these. There is wide-spread consensus among researchers working with a range of animal models and human cells that increased sortilin expression and decreased receptor expression are associated with amyloid beta and/or amyloid precursor protein. PMID:28838071
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A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease.
Reddy, P Hemachandra
2017-01-01
The purpose of this mini-forum, "Neurotransmitters and Alzheimer's Disease", is to critically assess the current status of neurotransmitters in Alzheimer's disease. Neurotransmitters are essential neurochemicals that maintain synaptic and cognitive functions in mammals, including humans, by sending signals across pre- to post-synaptic neurons. Authorities in the fields of synapses and neurotransmitters of Alzheimer's disease summarize the current status of basic biology of synapses and neurotransmitters, and also update the current status of clinical trials of neurotransmitters in Alzheimer's disease. This article discusses the prevalence, economic impact, and stages of Alzheimer's dementia in humans.
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Multigrid techniques for unstructured meshes
NASA Technical Reports Server (NTRS)
Mavriplis, D. J.
1995-01-01
An overview of current multigrid techniques for unstructured meshes is given. The basic principles of the multigrid approach are first outlined. Application of these principles to unstructured mesh problems is then described, illustrating various different approaches, and giving examples of practical applications. Advanced multigrid topics, such as the use of algebraic multigrid methods, and the combination of multigrid techniques with adaptive meshing strategies are dealt with in subsequent sections. These represent current areas of research, and the unresolved issues are discussed. The presentation is organized in an educational manner, for readers familiar with computational fluid dynamics, wishing to learn more about current unstructured mesh techniques.
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How do you know it is true? Integrity in research and publications: AOA critical issues.
Buckwalter, Joseph A; Tolo, Vernon T; O'Keefe, Regis J
2015-01-07
High-quality medical care is the result of clinical decisions based upon scientific principles garnered from basic, translational, and clinical research. Information regarding the natural history of diseases and their responses to various treatments is introduced into the medical literature through the approximately one million PubMed journal articles published each year. Pharmaceutical and device companies, universities, departments, and researchers all stand to gain from research publication. Basic and translational research is highly competitive. Success in obtaining research funding and career advancement requires scientific publication in the medical literature. Clinical research findings can lead to changes in the pattern of orthopaedic practice and have implications for the utilization of pharmaceuticals and orthopaedic devices. Research findings can be biased by ownership of patents and materials, funding sources, and consulting arrangements. The current high-stakes research environment has been characterized by an increase in plagiarism, falsification or manipulation of data, selected presentation of results, research bias, and inappropriate statistical analyses. It is the responsibility of the orthopaedic community to work collaboratively with industry, universities, departments, and medical researchers and educators to ensure the integrity of the content of the orthopaedic literature and to enable the incorporation of best practices in the care of orthopaedic patients. Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.
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Is the use of sentient animals in basic research justifiable?
2010-01-01
Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities. PMID:20825676
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Is the use of sentient animals in basic research justifiable?
Greek, Ray; Greek, Jean
2010-09-08
Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities.
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Homosexuality and Normality: Basic Knowledge and Practical Considerations for School Consultation
ERIC Educational Resources Information Center
Sherblom, Stephen A.; Bahr, Michael W.
2008-01-01
In the United States, controversy persists regarding what it means for heterosexuality to be the norm, or more pointedly, what it means for those not strictly heterosexual to be outside the norm. It is important that consultants in schools be aware of the current state of research bearing on homosexuality. Consultation provides a viable approach…
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Expanding the Basic Science Debate: The Role of Physics Knowledge in Interpreting Clinical Findings
ERIC Educational Resources Information Center
Goldszmidt, Mark; Minda, John Paul; Devantier, Sarah L.; Skye, Aimee L.; Woods, Nicole N.
2012-01-01
Current research suggests a role for biomedical knowledge in learning and retaining concepts related to medical diagnosis. However, learning may be influenced by other, non-biomedical knowledge. We explored this idea using an experimental design and examined the effects of causal knowledge on the learning, retention, and interpretation of medical…
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Earthquake prediction research at the Seismological Laboratory, California Institute of Technology
Spall, H.
1979-01-01
Nevertheless, basic earthquake-related information has always been of consuming interest to the public and the media in this part of California (fig. 2.). So it is not surprising that earthquake prediction continues to be a significant reserach program at the laboratory. Several of the current spectrum of projects related to prediction are discussed below.
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The Role of Emotion in Word Learning
ERIC Educational Resources Information Center
Doan, S. N.
2010-01-01
The way in which emotion interacts with cognition has been of great interest to researchers for hundreds of years. Emotion has been shown to play an important role in attention, learning and memory. However, the way in which emotion influences the basic process of word learning in infancy has largely been ignored. In the current paper, the…
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Analyses of User Rationality and System Learnability: Performing Task Variants in User Tests
ERIC Educational Resources Information Center
Law, Effie Lai-Chong; Blazic, Borka Jerman; Pipan, Matic
2007-01-01
No systematic empirical study on investigating the effects of performing task variants on user cognitive strategy and behaviour in usability tests and on learnability of the system being tested has been documented in the literature. The current use-inspired basic research work aims to identify the underlying cognitive mechanisms and the practical…
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ERIC Educational Resources Information Center
Burns, Matthew K.; Dean, Vincent J.; Foley, Sarah
2004-01-01
Research has consistently demonstrated that strategic preteaching activities led to improved reading fluency, but lacked studies examining the effect on reading comprehension. The current study investigated the effect of teaching unknown key words as a preteaching strategy with 20 students identified as learning disabled in basic reading skills…
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The Role of the Occupational Therapist in the Treatment of Children with Eating Disorders
ERIC Educational Resources Information Center
Bradford, Robert; Holliday, Megan; Schultz, Amy; Moser, Christy
2015-01-01
The prevalence of childhood eating disorders is increasing in pediatric practice across the country. It is therefore important for occupational therapists to be familiar with current research, resources, and intervention strategies related to a variety of eating diagnoses. In this column we highlight basic definitions of a variety of eating…
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An overview of computer vision
NASA Technical Reports Server (NTRS)
Gevarter, W. B.
1982-01-01
An overview of computer vision is provided. Image understanding and scene analysis are emphasized, and pertinent aspects of pattern recognition are treated. The basic approach to computer vision systems, the techniques utilized, applications, the current existing systems and state-of-the-art issues and research requirements, who is doing it and who is funding it, and future trends and expectations are reviewed.
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1997-04-30
Currently there are no systems available which allow for economical and accurate subsurface imaging of remediation sites. In some cases, high...system to address this need. This project has been very successful in showing a promising new direction for high resolution subsurface imaging . Our
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Health in Day Care: A Guide for Day Care Providers in Massachusetts.
ERIC Educational Resources Information Center
Kendrick, Abby Shapiro, Ed.; Messenger, Katherine P., Ed.
This reference manual and resource guide describes high standards for health policies and day care procedures that reflect current research and recommendations of experts. Chapters 1 and 2, which concern day care's role in health, cover health education in day care and the basics relating to policies, providers, and records. Chapters 3-5 concern…
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Communication Skills of a Teacher and Its Role in the Development of the Students' Academic Success
ERIC Educational Resources Information Center
Khan, Alamgir; Khan, Salahuddin; Zia-Ul-Islam, Syed; Khan, Manzoor
2017-01-01
Basically the current study sought to assess the perception of students regarding the role of teacher communication skills in their academics success. Comprehensive questionnaire carrying information including social economic and demographic aspects of the study was designed by the researcher to achieve the set objectives. All those universities…
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ERIC Educational Resources Information Center
Fienup, Daniel M.; Mylan, Sanaa E.; Brodsky, Julia; Pytte, Carolyn
2016-01-01
Equivalence-based instruction (EBI) has been used to successfully teach college-level concepts in research laboratories, but few studies have examined the results of such instruction on classroom performance. The current study answered a basic question about the ordering of training stimuli as well as an applied question regarding the effects of…
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Lighting New Fires: Catholic Schooling in America 25 Years after Vatican II.
ERIC Educational Resources Information Center
Guerra, Michael J.
Two basic questions about Catholic schools are addressed: (1) what is the current status of Catholic schooling in the United States? and (2) what does an analysis of recent trends suggest about the prospects for Catholic schools in the future? Recent research about Catholic schools can be divided into three categories. The first category is…
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J.F. Franklin; F. Hall; W. Laudenslayer; C. Maser; J. Nunan; J. Poppino; C.J. Ralph; T. Spies
1986-01-01
Interim definitions of old-growth forests are provided to guide efforts in land-management planning until comprehensive definitions based on research that is currently underway can be formulated. The basic criteria for identifying old-growth Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) and mixed-conifer forests in western Washington and...
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NASA Technical Reports Server (NTRS)
1972-01-01
Current research is reported on precise and accurate descriptions of the earth's surface and gravitational field and on time variations of geophysical parameters. A new computer program was written in connection with the adjustment of the BC-4 worldwide geometric satellite triangulation net. The possibility that an increment to accuracy could be transferred from a super-control net to the basic geodetic (first-order triangulation) was investigated. Coordinates of the NA9 solution were computed and were transformed to the NAD datum, based on GEOS 1 observations. Normal equations from observational data of several different systems and constraint equations were added and a single solution was obtained for the combined systems. Transformation parameters with constraints were determined, and the impact of computers on surveying and mapping is discussed.
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Towards large-scale, human-based, mesoscopic neurotechnologies.
Chang, Edward F
2015-04-08
Direct human brain recordings have transformed the scope of neuroscience in the past decade. Progress has relied upon currently available neurophysiological approaches in the context of patients undergoing neurosurgical procedures for medical treatment. While this setting has provided precious opportunities for scientific research, it also has presented significant constraints on the development of new neurotechnologies. A major challenge now is how to achieve high-resolution spatiotemporal neural recordings at a large scale. By narrowing the gap between current approaches, new directions tailored to the mesoscopic (intermediate) scale of resolution may overcome the barriers towards safe and reliable human-based neurotechnology development, with major implications for advancing both basic research and clinical translation. Copyright © 2015 Elsevier Inc. All rights reserved.
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NASA Technical Reports Server (NTRS)
Kahle, Anne B. (Editor); Abbott, Elsa (Editor)
1986-01-01
A workshop was held to bring together all users of data from NASA's airborne Thermal Infrared Multispectral Scanner (TIMS). The purpose was to allow users to compare results, data processing algorithms, and problems encountered; to update the users on the latest instrument changes and idiosyncracies, including distribution of the TIMS investigation guide; to inform the users of the wide range of problems that are currently being tackled by other TIMS investigators; to explore ways to expand the user community; to discuss current areas where more basic research is required; and to discuss the future directions of NASA's thermal infrared remote sensing programs. Also discussed were: geology, land use, archeology; and data processing and noise research.
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Cognitive correlates of performance in advanced mathematics.
Wei, Wei; Yuan, Hongbo; Chen, Chuansheng; Zhou, Xinlin
2012-03-01
Much research has been devoted to understanding cognitive correlates of elementary mathematics performance, but little such research has been done for advanced mathematics (e.g., modern algebra, statistics, and mathematical logic). To promote mathematical knowledge among college students, it is necessary to understand what factors (including cognitive factors) are important for acquiring advanced mathematics. We recruited 80 undergraduates from four universities in Beijing. The current study investigated the associations between students' performance on a test of advanced mathematics and a battery of 17 cognitive tasks on basic numerical processing, complex numerical processing, spatial abilities, language abilities, and general cognitive processing. The results showed that spatial abilities were significantly correlated with performance in advanced mathematics after controlling for other factors. In addition, certain language abilities (i.e., comprehension of words and sentences) also made unique contributions. In contrast, basic numerical processing and computation were generally not correlated with performance in advanced mathematics. Results suggest that spatial abilities and language comprehension, but not basic numerical processing, may play an important role in advanced mathematics. These results are discussed in terms of their theoretical significance and practical implications. ©2011 The British Psychological Society.
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Rauen, Katherine A; Huson, Susan M; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H; Zenker, Martin; Upadhyaya, Meena
2015-01-01
Neurofibromatosis type 1 (NF1) was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium "Recent Developments in Neurofibromatoses (NF) and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues" chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies. © 2014 Wiley Periodicals, Inc.
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Rauen, Katherine A.; Huson, Susan M.; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H.; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M.; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H.; Zenker, Martin; Upadhyaya, Meena
2014-01-01
Neurofibromatosis type 1 was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium “Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues” chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies. PMID:25393061
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Kehinde, Elijah O.
2013-01-01
The objective of this review article was to examine current and prospective developments in the scientific use of laboratory animals, and to find out whether or not there are still valid scientific benefits of and justification for animal experimentation. The PubMed and Web of Science databases were searched using the following key words: animal models, basic research, pharmaceutical research, toxicity testing, experimental surgery, surgical simulation, ethics, animal welfare, benign, malignant diseases. Important relevant reviews, original articles and references from 1970 to 2012 were reviewed for data on the use of experimental animals in the study of diseases. The use of laboratory animals in scientific research continues to generate intense public debate. Their use can be justified today in the following areas of research: basic scientific research, use of animals as models for human diseases, pharmaceutical research and development, toxicity testing and teaching of new surgical techniques. This is because there are inherent limitations in the use of alternatives such as in vitro studies, human clinical trials or computer simulation. However, there are problems of transferability of results obtained from animal research to humans. Efforts are on-going to find suitable alternatives to animal experimentation like cell and tissue culture and computer simulation. For the foreseeable future, it would appear that to enable scientists to have a more precise understanding of human disease, including its diagnosis, prognosis and therapeutic intervention, there will still be enough grounds to advocate animal experimentation. However, efforts must continue to minimize or eliminate the need for animal testing in scientific research as soon as possible. PMID:24217224
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Kehinde, Elijah O
2013-01-01
The objective of this review article was to examine current and prospective developments in the scientific use of laboratory animals, and to find out whether or not there are still valid scientific benefits of and justification for animal experimentation. The PubMed and Web of Science databases were searched using the following key words: animal models, basic research, pharmaceutical research, toxicity testing, experimental surgery, surgical simulation, ethics, animal welfare, benign, malignant diseases. Important relevant reviews, original articles and references from 1970 to 2012 were reviewed for data on the use of experimental animals in the study of diseases. The use of laboratory animals in scientific research continues to generate intense public debate. Their use can be justified today in the following areas of research: basic scientific research, use of animals as models for human diseases, pharmaceutical research and development, toxicity testing and teaching of new surgical techniques. This is because there are inherent limitations in the use of alternatives such as in vitro studies, human clinical trials or computer simulation. However, there are problems of transferability of results obtained from animal research to humans. Efforts are on-going to find suitable alternatives to animal experimentation like cell and tissue culture and computer simulation. For the foreseeable future, it would appear that to enable scientists to have a more precise understanding of human disease, including its diagnosis, prognosis and therapeutic intervention, there will still be enough grounds to advocate animal experimentation. However, efforts must continue to minimize or eliminate the need for animal testing in scientific research as soon as possible. © 2013 S. Karger AG, Basel.
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Horigian, Viviana E; Anderson, Austen R; Szapocznik, José
2016-09-01
In this article, we review the research evidence generated over 40 years on Brief Strategic Family Therapy illustrating the NIH stages of intervention development and highlighting the translational process. Basic research (Stage 0) led to the discovery of the characteristics of the population and the nature of the problems that needed to be addressed. This step informed the selection of an intervention model that addressed the problems presented by the population, but in a fashion that was congruent with the population's culture, defined in terms of its value orientations. From this basic research, an intervention that integrated structural and strategic elements was selected and refined through testing (Stage I). The second stage of translation (Stage II) included efficacy trials of a specialized engagement module that responded to challenges to the provision of services. It also included several other efficacy trials that documented the effects of the intervention, mostly in research settings or with research therapists. Stages III/IV in the translational process led to the testing of the effectiveness of the intervention in real-world settings with community therapists and some oversight from the developer. This work revealed that an implementation/organizational intervention was required to achieve fidelity and sustainability of the intervention in real-world settings. The work is currently in Stage V in which new model development led to an implementation intervention that can ensure fidelity and sustainability. Future research will evaluate the effectiveness of the current implementation model in increasing adoption, fidelity, and long-term sustainability in real-world settings. © 2016 Family Process Institute.
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Marketing health services: the engineering of satisfaction.
MacStravic, R S
1984-12-01
Service marketing is the engineering of satisfaction, and the key to success is to identify and influence potential customers' expectations and then to fulfill those expectations. Patient satisfaction largely determines both a program's revenues and expenditures and the effectiveness of care received by patients. A program's ability to satisfy patients rests upon three basic elements: research, design, and communication. Research should be on two levels. The first is basic market assessment and analysis, and should reveal overall market potential by focusing on consumers' expectations, unmet needs, and level of satisfaction. From this stage of research, the organization should be able to identify current programs that are secure and stable, those which have significant growth potential, those which are threatened by competition, and those which have little future. This research also should indicate the potential for new programs and for new markets for existing programs. The second level of research focuses on a specific program (whether current or proposed) and is the basis for program design. The organization can tailor the program to consumers' expectations in everything from services provided to price of parking and other amenities. Research also provides a basis for communications. Not only can communications influence a potential customer to try a provider, but also care providers can use communications during and after the service experience to reinforce what might have been a casual decision. Ideally, all communication that occurs between patients and providers should serve marketing as well as diagnostic and therapeutic purposes. It can shape patients' expectations, reinforce satisfaction when those expectations have been fulfilled, and convey the provider's caring and concern.
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The development of aerospace polyimide adhesives
NASA Technical Reports Server (NTRS)
St.clair, A. K.; St.clair, T. L.
1983-01-01
Few materials are available which can be used as aerospace adhesives at temperatures in the range of 300 C. The Materials Division at NASA-Langley Research Center developed several high temperature polyimide adhesives to fulfill the stringent needs of current aerospace programs. These adhesives are the result of a decade of basic research studies on the structure property relationships of both linear and addition aromatic polyimides. The development of both in house and commercially available polyimides is reviewed with regards to their potential for use as aerospace adhesives.
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Mineback Stimulation Research Experiments
DOE Office of Scientific and Technical Information (OSTI.GOV)
Warpinski, N.R.
The objective of the Mineback Stimulation Research Experiments is to improve hydraulic fracture stimulation technology by providing an in situ laboratory where basic processes and mechanisms that control and influence fracture propagation can be observed, measured and understood. While previous tests have been instrumental in providing an understanding of the mechanisms controlling fracture height, current experiments are focused on fluid flow through the created fracture and the associated pressure drops and crack widths. Work performed, accomplishments and future plans are presented. 7 refs., 2 figs.
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Mechanisms, applications, and perspectives of antiviral RNA silencing in plants
Garcia-Ruiz, Hernan; Ruiz, Mayra Teresa Garcia; Peralta, Sergio Manuel Gabriel; Gabriel, Cristina Betzabeth Miravel; El-Mounadi, Kautar
2017-01-01
Viral diseases of plants cause important economic losses due to reduction in crop quality and quantity to the point of threatening food security in some countries. Given the reduced availability of natural sources, genetic resistance to viruses has been successfully engineered for some plant-virus combinations. A sound understanding of the basic mechanisms governing plant-virus interactions, including antiviral RNA silencing, is the foundation to design better management strategies and biotechnological approaches to engineer and implement antiviral resistance in plants. In this review, we present current molecular models to explain antiviral RNA silencing and its application in basic plant research, biotechnology and genetic engineering. PMID:28890589
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Fishbein, Diana H; Ridenour, Ty A; Stahl, Mindy; Sussman, Steve
2016-03-01
A broad-span, six-stage translational prevention model is presented, extending from the basic sciences-taking a multi-level systems approach, including the neurobiological sciences-through to globalization. The application of a very wide perspective of translation research from basic scientific discovery to international policy change promises to elicit sustainable, population-level reductions in behavioral health disorders. To illustrate the conceptualization and actualization of a program of translational prevention research, we walk through each stage of research to practice and policy using an exemplar, callous-unemotional (CU) traits. Basic science has identified neurobiological, psychophysiological, behavioral, contextual, and experiential differences in this subgroup, and yet, these findings have not been applied to the development of more targeted intervention. As a result, there are currently no programs considered especially effective for CU traits, likely because they do not specifically target underlying mechanisms. To prevent/reduce the prevalence of conduct disorder, it is critical that we transfer existing knowledge to subsequent translational stages, including intervention development, implementation, and scaling. And eventually, once resulting programs have been rigorously evaluated, replicated, and adapted across cultural, ethnic, and gender groups, there is potential to institutionalize them as well as call attention to the special needs of this population. In this paper, we begin to consider what resources and changes in research perspectives are needed to move along this translational spectrum.
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Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms
Burd, Christin E.; Gill, Matthew S.; Niedernhofer, Laura J.; Robbins, Paul D.; Austad, Steven N.; Barzilai, Nir
2016-01-01
Through the progress of basic science research, fundamental mechanisms that contribute to age-related decline are being described with increasing depth and detail. Although these efforts have identified new drug targets and compounds that extend life span in model organisms, clinical trials of therapeutics that target aging processes remain scarce. Progress in aging research is hindered by barriers associated with the translation of basic science discoveries into the clinic. This report summarizes discussions held at a 2014 Geroscience Network retreat focused on identifying hurdles that currently impede the preclinical development of drugs targeting fundamental aging processes. From these discussions, it was evident that aging researchers have varied perceptions of the ideal preclinical pipeline. To forge a clear and cohesive path forward, several areas of controversy must first be resolved and new tools developed. Here, we focus on five key issues in preclinical drug development (drug discovery, lead compound development, translational preclinical biomarkers, funding, and integration between researchers and clinicians), expanding upon discussions held at the Geroscience Retreat and suggesting areas for further research. By bringing these findings to the attention of the aging research community, we hope to lay the foundation for a concerted preclinical drug development pipeline. PMID:27535964
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100-kA vacuum current breaker of a modular design
NASA Astrophysics Data System (ADS)
Ivanov, V. P.; Vozdvijenskii, V. A.; Jagnov, V. A.; Solodovnikov, S. G.; Mazulin, A. V.; Ryjkov, V. M.
1994-05-01
Direct current breaker of a modular design is developed for the strong field tokamak power supply system. The power supply system comprises four 800 MW alternative current generators with 4 GJ flywheels, thyristor rectifiers providing inductive stores pumping by a current up to 100 kA for 1 - 4 sec. To form current pulses of various shapes in the tokamak windings current breakers are used with either pneumatic or explosive drive, at a current switching synchronously of not worse than 100 mks. Current breakers of these types require that the current conducting elements be replaced after each shot. For recent years vacuum arc quenching chambers with an axial magnetic field are successfully employed as repetitive performance current breakers, basically for currents up to 40 kA. In the report some results of researches of a vacuum switch modular are presented which we used as prototype switch for currents of the order of 100 kA.
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Invited review of a workshop: anabolic hormones in bone: basic research and therapeutic potential.
Margolis, R N; Canalis, E; Partridge, N C
1996-03-01
Age-, postmenopause-, and disease-related conditions that result in low bone mass represent important public health issues. Maintenance of bone mass is a balance between bone resorption and formation and is influenced by diet, body composition, activity level, and the interactions between and among a large number of hormones, growth factors, and cytokines. Recent research has emphasized establishing a more complete understanding of the hormonal regulation of bone and developing anabolic agents with therapeutic potential for the treatment of low bone mass. The NIDDK at the NIH recently sponsored a Workshop, entitled Anabolic Hormones in Bone: Basic Research and Therapeutic Potential, that attempted to define the current state of the art knowledge of hormones, growth factors, and cytokines that affect bone mass, with particular emphasis on those that could potentially have a role as anabolic agents in bone. This review presents a condensed proceedings of that workshop along with a summary of the optimal requisites for the development of anabolic agents with therapeutic potential in bone.
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The Utrecht approach to exercise in chronic childhood conditions: the decade in review.
van Brussel, Marco; van der Net, Janjaap; Hulzebos, Erik; Helders, Paul J M; Takken, Tim
2011-01-01
To summarize and discuss current evidence and understanding of clinical pediatric exercise physiology focusing on the work the research group at Utrecht and others have performed in the last decade in a variety of chronic childhood conditions as a continuation of the legacy of Dr Bar-Or. The report discusses current research findings on the cardiopulmonary exercise performance of children (and adolescents) with juvenile idiopathic arthritis, osteogenesis imperfecta, achondroplasia, hemophilia, cerebral palsy, spina bifida, cystic fibrosis, and childhood cancer. Exercise recommendations and contraindications are provided for each condition. Implications for clinical practice and future research in this area are discussed for each of the chronic conditions presented. The authors provide a basic framework for developing an individual and/or disease-specific training program, introduce the physical activity pyramid, and recommend a core set of clinical measures to be used in clinical research.
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Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span
Losada, Liliana; Amundsen, Cindy L.; Ashton-Miller, James; Chai, Toby; Close, Clare; Damaser, Margot; DiSanto, Michael; Dmochowski, Roger; Fraser, Matthew O.; Kielb, Stephanie J.; Kuchel, George; Mueller, Elizabeth R.; Parker-Autry, Candace; Wolfe, Alan J.
2016-01-01
Abstract Urologic and kidney problems are common in women across their life span and affect their daily life, including physical activity, sexual relations, social life, and future health. Urological health in women is still understudied and the underlying mechanisms of female urological dysfunctions are not fully understood. The Society for Women's Health Research (SWHR®) recognized the need to have a roundtable discussion where researchers and clinicians would define the current state of knowledge, gaps, and recommendations for future research directions to transform women's urological health. This report summarizes the discussions, which focused on epidemiology, clinical presentation, basic science, prevention strategies, and efficacy of current therapies. Experts around the table agreed on a set of research, education, and policy recommendations that have the potential to dramatically increase awareness and improve women's urological health at all stages of life. PMID:27285829
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ERIC Educational Resources Information Center
Robertson, L. Paul
Designed for use in basic electronics programs, this curriculum guide is comprised of twenty-nine units of instruction in five major content areas: Orientation, Basic Principles of Electricity/Electronics, Fundamentals of Direct Current, Fundamentals of Alternating Current, and Applying for a Job. Each instructional unit includes some or all of…
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Statistical learning and language acquisition
Romberg, Alexa R.; Saffran, Jenny R.
2011-01-01
Human learners, including infants, are highly sensitive to structure in their environment. Statistical learning refers to the process of extracting this structure. A major question in language acquisition in the past few decades has been the extent to which infants use statistical learning mechanisms to acquire their native language. There have been many demonstrations showing infants’ ability to extract structures in linguistic input, such as the transitional probability between adjacent elements. This paper reviews current research on how statistical learning contributes to language acquisition. Current research is extending the initial findings of infants’ sensitivity to basic statistical information in many different directions, including investigating how infants represent regularities, learn about different levels of language, and integrate information across situations. These current directions emphasize studying statistical language learning in context: within language, within the infant learner, and within the environment as a whole. PMID:21666883
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Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application.
Klein, Matthias S; Shearer, Jane
2016-01-01
Type 2 diabetes (T2D) and its comorbidities have reached epidemic proportions, with more than half a billion cases expected by 2030. Metabolomics is a fairly new approach for studying metabolic changes connected to disease development and progression and for finding predictive biomarkers to enable early interventions, which are most effective against T2D and its comorbidities. In metabolomics, the abundance of a comprehensive set of small biomolecules (metabolites) is measured, thus giving insight into disease-related metabolic alterations. This review shall give an overview of basic metabolomics methods and will highlight current metabolomics research successes in the prediction and diagnosis of T2D. We summarized key metabolites changing in response to T2D. Despite large variations in predictive biomarkers, many studies have replicated elevated plasma levels of branched-chain amino acids and their derivatives, aromatic amino acids and α-hydroxybutyrate ahead of T2D manifestation. In contrast, glycine levels and lysophosphatidylcholine C18:2 are depressed in both predictive studies and with overt disease. The use of metabolomics for predicting T2D comorbidities is gaining momentum, as are our approaches for translating basic metabolomics research into clinical applications. As a result, metabolomics has the potential to enable informed decision-making in the realm of personalized medicine.
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Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application
Klein, Matthias S.; Shearer, Jane
2016-01-01
Type 2 diabetes (T2D) and its comorbidities have reached epidemic proportions, with more than half a billion cases expected by 2030. Metabolomics is a fairly new approach for studying metabolic changes connected to disease development and progression and for finding predictive biomarkers to enable early interventions, which are most effective against T2D and its comorbidities. In metabolomics, the abundance of a comprehensive set of small biomolecules (metabolites) is measured, thus giving insight into disease-related metabolic alterations. This review shall give an overview of basic metabolomics methods and will highlight current metabolomics research successes in the prediction and diagnosis of T2D. We summarized key metabolites changing in response to T2D. Despite large variations in predictive biomarkers, many studies have replicated elevated plasma levels of branched-chain amino acids and their derivatives, aromatic amino acids and α-hydroxybutyrate ahead of T2D manifestation. In contrast, glycine levels and lysophosphatidylcholine C18:2 are depressed in both predictive studies and with overt disease. The use of metabolomics for predicting T2D comorbidities is gaining momentum, as are our approaches for translating basic metabolomics research into clinical applications. As a result, metabolomics has the potential to enable informed decision-making in the realm of personalized medicine. PMID:26636104
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Basic nursing care: The most provided, the least evidence based - A discussion paper.
Zwakhalen, Sandra M G; Hamers, Jan P H; Metzelthin, Silke F; Ettema, Roelof; Heinen, Maud; de Man-Van Ginkel, Janneke M; Vermeulen, Hester; Huisman-de Waal, Getty; Schuurmans, Marieke J
2018-06-01
To describe and discuss the "Basic Care Revisited" (BCR) research programme, a collaborative initiative that contributes to evidence-based basic nursing care and raises awareness about the importance of basic nursing care activities. While basic nursing care serves nearly all people at some point in their lifetime, it is poorly informed by evidence. There is a need to prioritise and evaluate basic nursing care activities to improve patient outcomes and improve the quality of care. Discussion paper METHOD: The discussion presented in this paper is based on nursing literature and theory and supported by the authors' clinical and research experiences. We present the developmental process and content of a research programme called "Basic Care Revisited" (BCR) as a solution to move forward and improve basic nursing care. To prioritise basic nursing care, we propose a research programme entitled "Basic Care Revisited" that aims to create awareness and expand knowledge on evidence-based basic nursing care by addressing four basic nursing care themes (bathing and dressing, communication, mobility, and nutrition) in different settings. The paper discusses a pathway to create a sustainable and productive research collaborative on basic nursing care and addresses issues to build research capacity. Revaluation of these important nursing activities will not only positively influence patient outcomes, but also have an impact on staff outcomes and organisational outcomes. © 2018 John Wiley & Sons Ltd.
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A Researcher's Guide to Mass Spectrometry-Based Proteomics
Savaryn, John P.; Toby, Timothy K.; Kelleher, Neil L.
2016-01-01
Mass spectrometry (MS) is widely recognized as a powerful analytical tool for molecular research. MS is used by researchers around the globe to identify, quantify, and characterize biomolecules like proteins from any number of biological conditions or sample types. As instrumentation has advanced, and with the coupling of liquid chromatography (LC) for high-throughput LC-MS/MS, a proteomics experiment measuring hundreds to thousands of proteins/protein groups is now commonplace. While expert practitioners who best understand the operation of LC-MS systems tend to have strong backgrounds in physics and engineering, consumers of proteomics data and technology are not exposed to the physio-chemical principles underlying the information they seek. Since articles and reviews tend not to focus on bridging this divide, our goal here is to span this gap and translate MS ion physics into language intuitive to the general reader active in basic or applied biomedical research. Here, we visually describe what happens to ions as they enter and move around inside a mass spectrometer. We describe basic MS principles, including electric current, ion optics, ion traps, quadrupole mass filters, and Orbitrap FT-analyzers. PMID:27553853
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Boettler, Tobias; Moradpour, Darius; Thimme, Robert; Zoulim, Fabien
2014-09-01
The EASL Monothematic Conference on Translational Research in Viral Hepatitis brought together a group of leading scientists and clinicians working on both, basic and clinical aspects of viral hepatitis, thereby building bridges from bench to bedside. This report recapitulates the presentations and discussions at the conference held in Lyon, France on November 29-30, 2013. In recent years, great advances have been made in the field of viral hepatitis, particularly in hepatitis C virus (HCV) infection. The identification of IL28B genetic polymorphisms as a major determinant for spontaneous and treatment-induced HCV clearance was a seminal discovery. Currently, hepatologists are at the doorstep of even greater advances, with the advent of a wealth of directly acting antivirals (DAAs) against HCV. Indeed, promising results have accumulated over the last months and few years, showing sustained virological response (SVR) rates of up to 100% with interferon-free DAA combination therapies. Thus, less than 25 years after its identification, HCV infection may soon be curable in the vast majority of patients, highlighting the great success of HCV research over the last decades. However, viral hepatitis and its clinical complications such as liver cirrhosis and hepatocellular carcinoma (HCC) remain major global challenges. New therapeutic strategies to tackle hepatitis B virus (HBV) and hepatitis D virus (HDV) infection are needed, as current therapies have undeniable limitations. Nucleoside/nucleotide analogues (NUC) can efficiently control HBV replication and reduce or even reverse liver damage. However, these drugs have to be given for indefinite periods in most patients to maintain virological and biochemical responses. Although sustained responses off treatment can be achieved by treatment with (pegylated) interferon-α, only about 10-30% of patients effectively resolve chronic hepatitis B. It was the goal of this conference to review the progress made over the last years in chronic viral hepatitis research and to identify key questions that need to be addressed in order to close the gap between basic and clinical research and to develop novel preventive and treatment approaches for this most common cause of liver cirrhosis and HCC. Copyright © 2014. Published by Elsevier B.V. All rights reserved.
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ERIC Educational Resources Information Center
Ruhland, Sheila K.; Wilkinson, Richard F.
This document provides an overview of a project to identify the basic academic skills, advanced academic skills, and the higher-order workplace competencies for marketing education. It describes the following project activities: review of current literature and research in the field; review by business and industry representatives of the skills…
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AFRL Nanoscience Technologies: Applications, Transitions and Innovations
2010-01-01
other electromagnetic energy; they can interact with magnetic domains for improved superconductivity; they strengthen metals by resisting the motion of...thick platinum silicide (PtSi) layer on a silicon substrate. The basic research to establish the process of internal photoemission responsible for...pulses, saving 150 lbs per aircraft over the current metal shielding. Electrically conductive coatings using nickel nanostrands are now fielded in other
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NASA Technical Reports Server (NTRS)
Gray, Robert M.
1989-01-01
During the past ten years Vector Quantization (VQ) has developed from a theoretical possibility promised by Shannon's source coding theorems into a powerful and competitive technique for speech and image coding and compression at medium to low bit rates. In this survey, the basic ideas behind the design of vector quantizers are sketched and some comments made on the state-of-the-art and current research efforts.
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ERIC Educational Resources Information Center
Suro, Roberto; Suárez-Orozco, Marcelo M.; Canizales, Stephanie L.
2015-01-01
A parent's immigration status influences how a child grows up. That basic finding is grounded in the broad mainstream of current research on childhood development, which has concluded that parental factors can be powerful determinants of their offspring's well being all the way into adulthood. As this report shows, a parent's immigration status…
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The Great Lake Erie. A Reference Text for Educators and Communicators.
ERIC Educational Resources Information Center
Fortner, Rosanne W., Ed.; Mayer, Victor J., Ed.
The purpose of this volume is to present a body of basic information about the Great Lakes that is current and based on sound research. Such information is frequently difficult to locate, especially in one reference, and equally difficult to decipher and evaluate. The 16 essays contained in this book deal with a variety of topics including the…
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Christoph Keinn; Goran Stahl
2009-01-01
Current research in forest inventory focuses very much on technical-statistical problems geared mainly to the optimization of data collection and information generation. The basic assumption is that better information leads to better decisions and, therefore, to better forest management and forest policy. Not many studies, however, strive to explicitly establish the...
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ERIC Educational Resources Information Center
Carman, Priscilla S.
These two documents are products of a project to improve the capability of the Pennsylvania Regional Staff Development Centers to provide current, research-based workplace literacy training and technical assistance to adult basic and literacy education programs. The final report describes these project activities: development of training materials…
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SPAN: Astronomy and astrophysics
NASA Technical Reports Server (NTRS)
Thomas, Valerie L.; Green, James L.; Warren, Wayne H., Jr.; Lopez-Swafford, Brian
1987-01-01
The Space Physics Analysis Network (SPAN) is a multi-mission, correlative data comparison network which links science research and data analysis computers in the U.S., Canada, and Europe. The purpose of this document is to provide Astronomy and Astrophysics scientists, currently reachable on SPAN, with basic information and contacts for access to correlative data bases, star catalogs, and other astrophysic facilities accessible over SPAN.
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Basic Framework to Understand Identity Development in a Multicultural Context
ERIC Educational Resources Information Center
Shaughnessy, Michael F.; Valdez, Gilbert
2012-01-01
In the lead article, Persson (2012a) focuses on salient issues that have not as yet been addressed by others, and which are relevant, and germane. With the advent of the Internet and web and e-mail, conversation and discussion among scholars have increased tremendously. At the current time, researchers are able to share their data, their thoughts…
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ERIC Educational Resources Information Center
Hubble, Judy Hafley
A study explored the nature of intake procedures of Texas adult education programs. Research on barriers to attendance and strategies for retention were reviewed, and the current use of intake procedures to identify and address barriers to attendance was summarized through a survey of 374 Literacy, Even Start Family Literacy, Adult Basic Education…
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ERIC Educational Resources Information Center
Saarti, Jarmo; Tuominen, Kimmo
2017-01-01
Introduction: Even though the current publishing model is based on digital dissemination, it still utilizes some of the basic principles of printed culture. Recently a policy emphasis towards open access has been set for publicly funded research. This paper reports on a study of the practices, business models and values linked with scholarly…
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Drugs and the Nation's High School Students: Five Year National Trends. 1979 Highlights.
ERIC Educational Resources Information Center
Johnston, Lloyd D.; And Others
The current prevalence of drug use among American high school seniors, and trends in drug use since 1975, were investigated as part of the program entitled "Monitoring the Future: A Continuing Study of the Lifestyles and Values of Youth," funded by the National Institute on Drug Abuse. The basic research design involved data collection from high…
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ERIC Educational Resources Information Center
De Greef, Maurice; Verte, Dominique; Segers, Mien
2012-01-01
Our current knowledge society does not only have an impact on labour market demands, but its citizens also have to cope with increasing social demands. A growing number of vulnerable adults lack basic competences and therefore risk social exclusion. In this respect, The European Commission as well as the OECD agree that adult education can play a…
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Public and K-12 Teacher Members. NEA Research/Gallup Opinion Polls. Spring 1987 Annual Public Polls.
ERIC Educational Resources Information Center
National Education Association, Washington, DC.
The annual National Education Association opinion polls provide data comparing opinions held by the public and teachers on current and ongoing issues of concern to the education community. The 1987 polls focused on priorities for federal, state, and local government expenditures, on measures to improve education in the basics, and on sources of…
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ERIC Educational Resources Information Center
Peters, Wayne D.; Turk, James L.
2014-01-01
According to these authors, Canada is in need of a new science policy and strategy. The current direction of the federal government is threatening to impede scientific progress and compromise the integrity and independence of public science. This is reflected in the government's waning commitment to funding basic research; its attempts to steer…
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ERIC Educational Resources Information Center
Elmelegy, Reda Ibrahim
2015-01-01
The current research aims at clarifying how school-based management (SBM) can contribute to achieve the decision-making quality in Egyptian general secondary schools and determine the requirements of quality decision-making. It depends on the descriptive method in order to acknowledge the basics of the SBM and its relationship with the quality of…
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A Methodology for Teaching Rhetorical Fundamentals in a Course Centered Around Social Movements.
ERIC Educational Resources Information Center
Palleschi, Patricia
This paper attempts to incorporate the current research done on the rhetoric of social movements into a coherent syllabus for a basic rhetoric course. It deals with the adaptation of the tools of rhetoric at the disposal of the beginning student into a procedure for an analysis of social movements and provides that such an analysis give the…
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Maree, Jacobus G
2006-02-01
Employability seems to be a major consideration for prospective students' career choices. To facilitate accountable career counseling understanding of students' needs and choices of careers through research is essential. Programs for increased specific training are needed as well as improvement in basic training to meet a growing national labor crisis in South Africa.
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Response to Comartin, Kernsmith, and Miles' (2010) Michigan Sex Offender Registration Study
ERIC Educational Resources Information Center
Prescott, David S.
2010-01-01
Basic human respect compels everyone to ask about the effect of the current policies to prevent further abuse on family members of those who have abused. Sadly, only a handful of researchers are examining the effects of policies on the affected parties, such as victims, the abusers themselves, or their families. No one yet has asked a random…
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ERIC Educational Resources Information Center
Brinkley-Etzkorn, Karen E.
2016-01-01
The purpose of this study was to investigate the challenges and solutions encountered by Adult Basic Education (ABE) programs currently serving older adults seeking a GED credential in states where this is the only high school equivalency option available. The following questions guided this research: (1) what are the perceived characteristics and…
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Issues in Biomedical Research Data Management and Analysis: Needs and Barriers
Anderson, Nicholas R.; Lee, E. Sally; Brockenbrough, J. Scott; Minie, Mark E.; Fuller, Sherrilynne; Brinkley, James; Tarczy-Hornoch, Peter
2007-01-01
Objectives A. Identify the current state of data management needs of academic biomedical researchers. B. Explore their anticipated data management and analysis needs. C. Identify barriers to addressing those needs. Design A multimodal needs analysis was conducted using a combination of an online survey and in-depth one-on-one semi-structured interviews. Subjects were recruited via an e-mail list representing a wide range of academic biomedical researchers in the Pacific Northwest. Measurements The results from 286 survey respondents were used to provide triangulation of the qualitative analysis of data gathered from 15 semi-structured in-depth interviews. Results Three major themes were identified: 1) there continues to be widespread use of basic general-purpose applications for core data management; 2) there is broad perceived need for additional support in managing and analyzing large datasets; and 3) the barriers to acquiring currently available tools are most commonly related to financial burdens on small labs and unmet expectations of institutional support. Conclusion Themes identified in this study suggest that at least some common data management needs will best be served by improving access to basic level tools such that researchers can solve their own problems. Additionally, institutions and informaticians should focus on three components: 1) facilitate and encourage the use of modern data exchange models and standards, enabling researchers to leverage a common layer of interoperability and analysis; 2) improve the ability of researchers to maintain provenance of data and models as they evolve over time though tools and the leveraging of standards; and 3) develop and support information management service cores that could assist in these previous components while providing researchers with unique data analysis and information design support within a spectrum of informatics capabilities. PMID:17460139
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26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.
Code of Federal Regulations, 2010 CFR
2010-04-01
... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...
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26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.
Code of Federal Regulations, 2011 CFR
2011-04-01
... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...
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26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.
Code of Federal Regulations, 2014 CFR
2014-04-01
... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...
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26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.
Code of Federal Regulations, 2013 CFR
2013-04-01
... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...
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26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.
Code of Federal Regulations, 2012 CFR
2012-04-01
... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...
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Opportunities for research in aerothermodynamics
NASA Technical Reports Server (NTRS)
Graham, R. W.
1983-01-01
"Aerothermodynamics' involves the disciplines of chemistry, thermodynamics, fluid mechanics and heat transfer which have collaborative importance in propulsion systems. There are growing opportunities for the further application of these disciplines to improve the methodology for the design of advanced gas turbines; particularly, the combustor and turbine. Design procedures follow empirical or cut and try guidelines. The tremendous advances in computational analysis and in instrumentation techniques hold promise for research answers to complex physical processes that are currently not well understood. The transfer of basic research understanding to engineering design should result in shorter, less expensive development commitments for engines. The status and anticipated opportunities in research topics relevant to combustors and turbines is reviewed.
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Ignition study of a petrol/CNG single cylinder engine
NASA Astrophysics Data System (ADS)
Khan, N.; Saleem, Z.; Mirza, A. A.
2005-11-01
Benefits of laser ignition over the electrical ignition system for Compressed Natural Gas (CNG) engines have fuelled automobile industry and led to an extensive research on basic characteristics to switch over to the emerging technologies. This study was undertaken to determine the electrical and physical characteristics of the electric spark ignition of single cylinder petrol/CNG engine to determine minimum ignition requirements and timeline of ignition events to use in subsequent laser ignition study. This communication briefly reviews the ongoing research activities and reports the results of this experimental study. The premixed petrol and CNG mixtures were tested for variation of current and voltage characteristics of the spark with speed of engine. The current magnitude of discharge circuit was found to vary linearly over a wide range of speed but the stroke to stroke fire time was found to vary nonlinearly. The DC voltage profiles were observed to fluctuate randomly during ignition process and staying constant in rest of the combustion cycle. Fire to fire peaks of current amplitudes fluctuated up to 10% of the peak values at constant speed but increased almost linearly with increase in speed. Technical barriers of laser ignition related to threshold minimum ignition energy, inter-pulse durations and firing sequence are discussed. Present findings provide a basic initiative and background information for designing suitable timeline algorithms for laser ignited leaner direct injected CNG engines.
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NASA Astrophysics Data System (ADS)
Lagowski, J. J.
1996-02-01
Increasingly, new science and technology are expected to solve the nation's current economic malaise. Unfortunately, virtually no industrial laboratories are devoted to anything close to basic research, which, historically, has been the source of many of the innovations on which industry has flourished in the past. For example, a number of industrial laboratories contributed significantly to our basic understanding of polymer science and, in the course of doing so, made better and more useful plastics. The strength of the American system of higher education has always been basic research, which is also the cornerstone of the process of graduate education. Before World War II, academic research was the vehicle by which advanced students learned advanced skills--both cognitive and manipulative. It was the structure devised to produce exemplary scientists who could then apply their skills in a number of different kinds of environments; the research results produced were generally of only secondary interest. Now, the academic research establishment has evolved into the source of the "strategic," "relevant," or "targeted" research that will solve the nation's economic problems. As expectations in this regard grow higher, guidelines are bound to become even more specific. Excessive over-direction of basic research activities can have the effect of throttling down the very industry-building discoveries that are so eagerly sought. From one point of view, targeted academic research often goes in the wrong direction. While it is true that most academic research starts off in some direction, it often does not finish going in that direction. The work that stands behind theses and dissertations often bears little resemblance to the problem that was defined when the student began his/her research. Almost every paper that is written as the result of a piece of academic research is either unsophisticatedin itsdetails or irrelevant, in spite of the initial hopes and promises. That process upon which academic research builds its ability to develop skilled scientists--a process that is not really dependent upon reaching a specific target--will not produce the science and technology that some say the nation needs to solve its economic problems. It is highly probable that the academic research now being supported will not have much effect upon our economic future; however, the people produced by that system will. Many careful observers have concluded that having universities do industry-relevant research would necessarily mean the abandonment of basic inquiry, a process akin to eating our seed corn. The collective wisdom of some industry executives is that undirected, long-term research does not pay off, a conclusion that is consonant with the general abandonment of research efforts in that sector. With industry increasingly disinclined to invest its resources in long-term or unfocussed projects, and NSF and other agency resources inadequate, basic research funding continues to be the target of politicians, calling for more industry-related effort. Research--a process designed to make discoveries or acquire knowledge--has many shades of meaning, which often muddies discussions. Academic research is designed to decrease our collective store of ignorance. Unanswered questions are the single-most valuable commodity we can lay before our graduate students and use as a focus for their advanced education. We do not understand how the vast store of information that exists, together with our ignorance, can be used to solve the nation's problems, which may have only a relatively short time base. Research that impacts products in six months is different in detail from research done as part of an academic graduate program. The focus and outcomes are different. Both are important for the well-being of the nation. The one produces skilled people and the other, short-term results of use to industry. Both extremes need to be supported--using separate kinds of arguments. If industry will not support developmental research, the Federal government should not confuse its efforts to encourage the development of well-qualified people with those designed to help industry do what it should do, but will not do. Economic pressures currently affect both kinds of research, but clear thinking is required to make effective use of extant resources.
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Basic Skills, Basic Writing, Basic Research.
ERIC Educational Resources Information Center
Trimmer, Joseph F.
1987-01-01
Overviews basic writing instruction and research by briefly discussing the history of remediation, results of a survey of basic writing programs in U.S. colleges and universities, and interviews with developmental textbook editors at major publishing houses. Finds that basic writing instruction continues to focus on sentence grammar. (MM)
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Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry
2014-01-01
Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed “too great an emphasis on guidelines and research ethics review”, which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities. PMID:24894063
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Workshop on Basic Research Opportunities in Photovoltaics
DOE Office of Scientific and Technical Information (OSTI.GOV)
Benner, J.; McConnell, R.; Deb, S., Editors
1999-08-25
The Basic Research Opportunities in Photovoltaics Workshop was held on May 3, 1999, in Seattle, Washington, in conjunction with the 195th Meeting of the Electrochemical Society. The workshop was structured into eight topics. Each topic area opened with a presentation in which the participants were asked to address the following: a brief introduction of the area of research; key research issues that were identified in an earlier workshop in 1992; what fundamental research has been done since then or is currently being done to address those issues; what are the research issues that are still relevant in light of advancesmore » made since the first workshop; identification of new fundamental research opportunities that will lead to important advances and innovations; and identification of significant commonalities and common research issues that have a cross-cutting impact, such as logically exist in silicon-based thin films, II-VI, and related materials. The topic areas discussed included amorphous and microcrystalline silicon, crystalline silicon, cadmium telluride, copper indium diselenide; III-V materials; novel materials and energy conversion approaches, semiconducting oxides, and characterization. After the meeting, participants in each working topic continued discussions by electronic means, completing journal articles that are to be published as a separate section in the ECS Proceedings of the ''PV for the 21st Century'' Symposium.« less
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Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry
2015-12-01
Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed 'too great an emphasis on guidelines and research ethics review', which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities. © 2014 John Wiley & Sons Ltd.
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34 CFR 350.5 - What definitions apply?
Code of Federal Regulations, 2010 CFR
2010-07-01
... classified on a continuum from basic to applied: (1) Basic research is research in which the investigator is... immediate application or utility. (2) Applied research is research in which the investigator is primarily... rehabilitation problem or need. Applied research builds on selected findings from basic research. (Authority: Sec...
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Conceptual planning for Space Station life sciences human research project
NASA Technical Reports Server (NTRS)
Primeaux, Gary R.; Miller, Ladonna J.; Michaud, Roger B.
1986-01-01
The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of the Facility, in view of representative experimentation requirement scenarios and with the intention of accommodating the Facility within the Initial Operational Capability configuration of the Space Station. Such basic engineering questions as orbital and ground logistics operations and hardware maintenance/servicing requirements are addressed. Biospherics, calcium homeostasis, endocrinology, exercise physiology, hematology, immunology, muscle physiology, neurosciences, radiation effects, and reproduction and development, are among the fields of inquiry encompassed by the Facility.
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Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives
Ngen, Ethel J.; Artemov, Dmitri
2017-01-01
Cell-based therapies are currently being developed for applications in both regenerative medicine and in oncology. Preclinical, translational, and clinical research on cell-based therapies will benefit tremendously from novel imaging approaches that enable the effective monitoring of the delivery, survival, migration, biodistribution, and integration of transplanted cells. Magnetic resonance imaging (MRI) offers several advantages over other imaging modalities for elucidating the fate of transplanted cells both preclinically and clinically. These advantages include the ability to image transplanted cells longitudinally at high spatial resolution without exposure to ionizing radiation, and the possibility to co-register anatomical structures with molecular processes and functional changes. However, since cellular MRI is still in its infancy, it currently faces a number of challenges, which provide avenues for future research and development. In this review, we describe the basic principle of cell-tracking with MRI; explain the different approaches currently used to monitor cell-based therapies; describe currently available MRI contrast generation mechanisms and strategies for monitoring transplanted cells; discuss some of the challenges in tracking transplanted cells; and suggest future research directions. PMID:28106829
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Middleton, Kellie K.; Barro, Victor; Muller, Bart; Terada, Satosha; Fu, Freddie H.
2012-01-01
Abstract Musculoskeletal injuries are the most common cause of severe long-term pain and physical disability, and affect hundreds of millions of people around the world. One of the most popular methods used to biologically enhance healing in the fields of orthopaedic surgery and sports medicine includes the use of autologous blood products, namely, platelet rich plasma (PRP). PRP is an autologous concentration of human platelets to supra-physiologic levels. At baseline levels, platelets function as a natural reservoir for growth factors including platelet-derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and insulin-like growth factor (IGF-I). PRP is commonly used in orthopaedic practice to augment healing in sports-related injuries of skeletal muscle, tendons, and ligaments. Despite its pervasive use, the clinical efficacy of PrP therapy and varying mechanisms of action have yet to be established. Basic science research has revealed that PRP exerts is effects through many downstream events secondary to release of growth factors and other bioactive factors from its alpha granules. These effects may vary depending on the location of injury and the concentration of important growth factors involved in various soft tissue healing responses. This review focuses on the effects of PrP and its associated bioactive factors as elucidated in basic science research. Current findings in PRP basic science research, which have shed light on its proposed mechanisms of action, have opened doors for future areas of PrP research. PMID:23576936
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"The Dilemma That Still Counts": Basic Writing at a Political Crossroads.
ERIC Educational Resources Information Center
Harrington, Susanmarie; Adler-Kassner, Linda
1998-01-01
Reviews definitions of basic writers and basic writing over the last 20 years. Argues that basic writers are not defined only in terms of institutional convenience. Offers future directions for basic writing research, suggesting that to learn more about basic writers, researchers must return to studies of error informed by basic writing's rich…
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Research progress on quantum informatics and quantum computation
NASA Astrophysics Data System (ADS)
Zhao, Yusheng
2018-03-01
Quantum informatics is an emerging interdisciplinary subject developed by the combination of quantum mechanics, information science, and computer science in the 1980s. The birth and development of quantum information science has far-reaching significance in science and technology. At present, the application of quantum information technology has become the direction of people’s efforts. The preparation, storage, purification and regulation, transmission, quantum coding and decoding of quantum state have become the hotspot of scientists and technicians, which have a profound impact on the national economy and the people’s livelihood, technology and defense technology. This paper first summarizes the background of quantum information science and quantum computer and the current situation of domestic and foreign research, and then introduces the basic knowledge and basic concepts of quantum computing. Finally, several quantum algorithms are introduced in detail, including Quantum Fourier transform, Deutsch-Jozsa algorithm, Shor’s quantum algorithm, quantum phase estimation.
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Culture, risk factors and suicide in rural China: a psychological autopsy case control study.
Zhang, J; Conwell, Y; Zhou, L; Jiang, C
2004-12-01
Previous research on sociocultural factors for Chinese suicide have been basically limited to single case studies or qualitative research with ethnographic methodology. The current study examines the major risk factors and some cultural uniqueness related to Chinese rural suicide using a quantitative design. This is a case control study with 66 completed suicides and 66 living controls obtained from psychological autopsy interviews in rural China. Both bivariate analyses and the multiple regression model have found that the Chinese rural suicide patterns are basically similar to those in most other cultures in the world: strong predictors of rural Chinese suicide are the psychopathological, psychological, and physical health variables, followed by social support and negative and stressful life events. Other significant correlates include lower education, poverty, religion, and family disputes. Culture has an important impact on suicide patterns in a society.
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Culture, risk factors and suicide in rural China: a psychological autopsy case control study
Zhang, J.; Conwell, Y.; Zhou, L.; Jiang, C.
2009-01-01
Objective Previous research on sociocultural factors for Chinese suicide have been basically limited to single case studies or qualitative research with ethnographic methodology. The current study examines the major risk factors and some cultural uniqueness related to Chinese rural suicide using a quantitative design. Method This is a case control study with 66 completed suicides and 66 living controls obtained from psychological autopsy interviews in rural China. Results Both bivariate analyses and the multiple regression model have found that the Chinese rural suicide patterns are basically similar to those in most other cultures in the world: strong predictors of rural Chinese suicide are the psychopathological, psychological, and physical health variables, followed by social support and negative and stressful life events. Other significant correlates include lower education, poverty, religion, and family disputes. Conclusion Culture has an important impact on suicide patterns in a society. PMID:15521827
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Malaria vaccines: looking back and lessons learnt
Lorenz, Veronique; Karanis, Panagiotis
2011-01-01
The current status of malaria vaccine approaches has the background of a long and arduous path of malaria disease control and vaccine development. Here, we critically review with regard to unilateral interventional approaches and highlight the impact of socioeconomic elements of malaria endemicity. The necessity of re-energizing basic research of malaria life-cycle and Plasmodium developmental biology to provide the basis for promising and cost-effective vaccine approaches and to reach eradication goals is more urgent than previously believed. We closely analyse the flaws of various vaccine approaches, outline future directions and challenges that still face us and conclude that the focus of the field must be shifted to the basic research efforts including findings on the skin stage of infection. We also reflect on economic factors of vaccine development and the impact of public perception when it comes to vaccine uptake. PMID:23569729
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Czajkowski, Susan M; Lynch, Minda R; Hall, Kara L; Stipelman, Brooke A; Haverkos, Lynne; Perl, Harold; Scott, Marcia S; Shirley, Mariela C
2016-03-01
The translation of basic behavioral science discoveries into practical strategies represents a promising approach to developing more effective preventive interventions to improve health. Since translational research inevitably involves making use of diverse perspectives from multiple disciplines, it is best conducted as a transdisciplinary enterprise. In this paper, we discuss current strategies used by NIH to support transdisciplinary translational behavioral (TDTB) research, summarize successful efforts, and highlight challenges encountered in conducting such work (ranging from conceptual to organizational to methodological). Using examples from NIH-funded projects we illustrate the potential benefits of, and barriers to, pursuing this type of research and discuss next steps and potential future directions for NIH-supported TDTB research.
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Enhancing In-Flight Transoceanic Communications Using Swift-64 Packet Mode Service
NASA Technical Reports Server (NTRS)
Slywczak, Richard A.
2004-01-01
Current aeronautical communications can be divided into two segments. The first provides state of the art, packet switched technology to the cabin passengers so that they have access to e-mail and web services. The second provides basic circuit switch communication technology to the cockpit, which does not use bandwidth as efficiently as packet switching nor promotes resource sharing. This paper explores the research efforts currently being conducted by the NASA/Glenn Research Center (GRC) for transoceanic communications. The goal is to bring packet mode services to both the cabin and the cockpit of the aircraft and be able to attain benefits by sharing the data link with cabin services. First, this paper will outline the goals of the program and detail the benefits and issues related to this research. We will explain our current laboratory setup and show an architecture implemented in the testbed. Finally, we will present a work plan that will show the progression of research over the next year. This plan will describe a complete cycle from conceptual design and laboratory implementation to the final flight testing.
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Wörsching, Jana; Padberg, Frank; Ertl-Wagner, Birgit; Kumpf, Ulrike; Kirsch, Beatrice; Keeser, Daniel
2016-10-01
Transcranial current stimulation approaches include neurophysiologically distinct non-invasive brain stimulation techniques widely applied in basic, translational and clinical research: transcranial direct current stimulation (tDCS), oscillating transcranial direct current stimulation (otDCS), transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS). Prefrontal tDCS seems to be an especially promising tool for clinical practice. In order to effectively modulate relevant neural circuits, systematic research on prefrontal tDCS is needed that uses neuroimaging and neurophysiology measures to specifically target and adjust this method to physiological requirements. This review therefore analyses the various neuroimaging methods used in combination with prefrontal tDCS in healthy and psychiatric populations. First, we provide a systematic overview on applications, computational models and studies combining neuroimaging or neurophysiological measures with tDCS. Second, we categorise these studies in terms of their experimental designs and show that many studies do not vary the experimental conditions to the extent required to demonstrate specific relations between tDCS and its behavioural or neurophysiological effects. Finally, to support best-practice tDCS research we provide a methodological framework for orientation among experimental designs. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Stahmer, Aubyn C.
2007-01-01
Autism researchers have identified a set of common effective practice elements for early intervention (EI) (e.g., intensive programming). The current study examined the reported about use of common elements of effective interventions in community EI settings. Eighty EI providers reported about their programs. The majority of participants reported using common effective elements, however, the depth and quality of the use of these elements was highly variable. Taking community program structure into account in future research will facilitate the development of methodologies, which immediately fit into the context of community programming rather than requiring program adaptation for use in the real world. Recommendations for using current community program structure to improve use of evidence-based practices are discussed. PMID:17086438
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Lustigman, Sara; Geldhof, Peter; Grant, Warwick N; Osei-Atweneboana, Mike Y; Sripa, Banchob; Basáñez, María-Gloria
2012-01-01
Successful and sustainable intervention against human helminthiases depends on optimal utilisation of available control measures and development of new tools and strategies, as well as an understanding of the evolutionary implications of prolonged intervention on parasite populations and those of their hosts and vectors. This will depend largely on updated knowledge of relevant and fundamental parasite biology. There is a need, therefore, to exploit and apply new knowledge and techniques in order to make significant and novel gains in combating helminthiases and supporting the sustainability of current and successful mass drug administration (MDA) programmes. Among the fields of basic research that are likely to yield improved control tools, the Disease Reference Group on Helminth Infections (DRG4) has identified four broad areas that stand out as central to the development of the next generation of helminth control measures: 1) parasite genetics, genomics, and functional genomics; 2) parasite immunology; 3) (vertebrate) host-parasite interactions and immunopathology; and 4) (invertebrate) host-parasite interactions and transmission biology. The DRG4 was established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR). The Group was given the mandate to undertake a comprehensive review of recent advances in helminthiases research in order to identify notable gaps and highlight priority areas. This paper summarises recent advances and discusses challenges in the investigation of the fundamental biology of those helminth parasites under the DRG4 Group's remit according to the identified priorities, and presents a research and development agenda for basic parasite research and enabling technologies that will help support control and elimination efforts against human helminthiases.
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Yamazaki, Yuka; Uka, Takanori; Shimizu, Haruhiko; Miyahira, Akira; Sakai, Tatsuo; Marui, Eiji
2013-02-01
The number of physicians engaged in basic sciences and teaching is sharply decreasing in Japan. To alleviate this shortage, central government has increased the quota of medical students entering the field. This study investigated medical students' interest in basic sciences in efforts to recruit talent. A questionnaire distributed to 501 medical students in years 2 to 6 of Juntendo University School of Medicine inquired about sex, grade, interest in basic sciences, interest in research, career path as a basic science physician, faculties' efforts to encourage students to conduct research, increases in the number of lectures, and practical training sessions on research. Associations between interest in basic sciences and other variables were examined using χ(2) tests. From among the 269 medical students (171 female) who returned the questionnaire (response rate 53.7%), 24.5% of respondents were interested in basic sciences and half of them considered basic sciences as their future career. Obstacles to this career were their original aim to become a clinician and concerns about salary. Medical students who were likely to be interested in basic sciences were fifth- and sixth-year students, were interested in research, considered basic sciences as their future career, considered faculties were making efforts to encourage medical students to conduct research, and wanted more research-related lectures. Improving physicians' salaries in basic sciences is important for securing talent. Moreover, offering continuous opportunities for medical students to experience research and encouraging advanced-year students during and after bedside learning to engage in basic sciences are important for recruiting talent.
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Smith, W.K.
1982-01-01
The mathematical method of determining in-situ stresses by overcoring, using either the U.S. Bureau of Mines Borehole Deformation Gage or the Commonwealth Scientific and Industrial Research Organisation Hollow Inclusion Stress Cell, is summarized, and data reduction programs for each type of instrument, written in BASIC, are presented. The BASIC programs offer several advantages over previously available FORTRAN programs. They can be executed on a desk-top microcomputer at or near the field site, allowing the investigator to assess the quality of the data and make decisions on the need for additional testing while the crew is still in the field. Also, data input is much simpler than with currently available FORTRAN programs; either English or SI units can be used; and standard deviations of the principal stresses are computed as well as those of the geographic components.
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Principles of Induction Accelerators
NASA Astrophysics Data System (ADS)
Briggs*, Richard J.
The basic concepts involved in induction accelerators are introduced in this chapter. The objective is to provide a foundation for the more detailed coverage of key technology elements and specific applications in the following chapters. A wide variety of induction accelerators are discussed in the following chapters, from the high current linear electron accelerator configurations that have been the main focus of the original developments, to circular configurations like the ion synchrotrons that are the subject of more recent research. The main focus in the present chapter is on the induction module containing the magnetic core that plays the role of a transformer in coupling the pulsed power from the modulator to the charged particle beam. This is the essential common element in all these induction accelerators, and an understanding of the basic processes involved in its operation is the main objective of this chapter. (See [1] for a useful and complementary presentation of the basic principles in induction linacs.)
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Investments in tuberculosis research - what are the gaps?
Khan, Mishal S; Fletcher, Helen; Coker, Richard
2016-08-25
Through decades of research, numerous studies have generated robust evidence about effective interventions for tuberculosis control. Yet, the global annual decline in incidence of approximately 1 % is evidence that current approaches and investment strategies are not sufficient. In this article, we assess recent tuberculosis research funding and discuss two critical gaps in funding and in scientific evidence from topics that have been left off the research priority agenda.We first examine research and development funding goals in the 2011-2015 Global Plan to Stop Tuberculosis and analyze disbursements to different research areas by funders worldwide in 2014. We then summarize, through a compilation of published literature and consultation with 35 researchers across multiple disciplines in the London School of Hygiene and Tropical Medicine TB Centre, priorities identified by the tuberculosis research community. Finally, we compare researchers' priority areas to the global funding agendas and activities.Our analysis shows that, among the five key research areas defined in the 2011-2015 Global Plan - namely drugs, basic science, vaccines, diagnostics and operational research - drug discovery and basic science on Mycobacterium tuberculosis accounted for 60 % of the $2 billion annual funding target. None of the research areas received the recommended level of funding. Operational research, which had the lowest target, received 66 % of its target funding, whereas new diagnostics received only 19 %. Although many of the priority research questions identified by researchers fell within the Global Plan categories, our analysis highlights important areas that are not explicitly mentioned in the current plan. These priority research areas included improved understanding of tuberculosis transmission dynamics, the role of social protection and social determinants, and health systems and policy research.While research priorities are increasingly important in light of the limited funding for tuberculosis, there is a risk that we neglect important research areas and encourage the formation of research silos. To ensure that funding priorities, researchers' agendas and national tuberculosis control policies are better coordinated, there should be more, and wider, dialogue between stakeholders in high tuberculosis burden countries, researchers, international policymakers and funders.
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Indicators for the use of robotic labs in basic biomedical research: a literature analysis
2017-01-01
Robotic labs, in which experiments are carried out entirely by robots, have the potential to provide a reproducible and transparent foundation for performing basic biomedical laboratory experiments. In this article, we investigate whether these labs could be applicable in current experimental practice. We do this by text mining 1,628 papers for occurrences of methods that are supported by commercial robotic labs. Using two different concept recognition tools, we find that 86%–89% of the papers have at least one of these methods. This and our other results provide indications that robotic labs can serve as the foundation for performing many lab-based experiments. PMID:29134146
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Charged dust phenomena in the near-Earth space environment.
Scales, W A; Mahmoudian, A
2016-10-01
Dusty (or complex) plasmas in the Earth's middle and upper atmosphere ultimately result in exotic phenomena that are currently forefront research issues in the space science community. This paper presents some of the basic criteria and fundamental physical processes associated with the creation, evolution and dynamics of dusty plasmas in the near-Earth space environment. Recent remote sensing techniques to probe naturally created dusty plasma regions are also discussed. These include ground-based experiments employing high-power radio wave interaction. Some characteristics of the dusty plasmas that are actively produced by space-borne aerosol release experiments are discussed. Basic models that may be used to investigate the characteristics of such dusty plasma regions are presented.
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Chinese health care system and clinical epidemiology
Sun, Yuelian; Gregersen, Hans; Yuan, Wei
2017-01-01
China has gone through a comprehensive health care insurance reform since 2003 and achieved universal health insurance coverage in 2011. The new health care insurance system provides China with a huge opportunity for the development of health care and medical research when its rich medical resources are fully unfolded. In this study, we review the Chinese health care system and its implication for medical research, especially within clinical epidemiology. First, we briefly review the population register system, the distribution of the urban and rural population in China, and the development of the Chinese health care system after 1949. In the following sections, we describe the current Chinese health care delivery system and the current health insurance system. We then focus on the construction of the Chinese health information system as well as several existing registers and research projects on health data. Finally, we discuss the opportunities and challenges of the health care system in regard to clinical epidemiology research. China now has three main insurance schemes. The Urban Employee Basic Medical Insurance (UEBMI) covers urban employees and retired employees. The Urban Residence Basic Medical Insurance (URBMI) covers urban residents, including children, students, elderly people without previous employment, and unemployed people. The New Rural Cooperative Medical Scheme (NRCMS) covers rural residents. The Chinese Government has made efforts to build up health information data, including electronic medical records. The establishment of universal health care insurance with linkage to medical records will provide potentially huge research opportunities in the future. However, constructing a complete register system at a nationwide level is challenging. In the future, China will demand increased capacity of researchers and data managers, in particular within clinical epidemiology, to explore the rich resources. PMID:28356772
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Focus on Basics: Connecting Research & Practice. Volume 8, Issue D
ERIC Educational Resources Information Center
Garner, Barbara, Ed.
2007-01-01
Learning disabilities is the theme of the latest issue of "Focus on Basics," the World Education publication that brings together research, policy, and practice in adult basic education. Starting with an update on research on neurobiology and dyslexia, this issue also examines how the adult basic education system supports students with…
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ERIC Educational Resources Information Center
Center for the Future of Teaching and Learning, 2010
2010-01-01
California's public schools have struggled since the passage of Proposition 13 in 1978, and today face enormous challenges to try to regain lost quality and standing as a national education leader. In light of the current economic crisis, competition for limited resources is fierce and the pressure is on to eliminate all but the basic "Three…
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Mechanisms and disease relevance of neutrophil extracellular trap formation.
Van Avondt, Kristof; Hartl, Dominik
2018-03-15
While the microscopic appearance of neutrophil extracellular traps (NETs) has fascinated basic researchers since its discovery, the (patho)physiological mechanisms triggering NET release, the disease relevance and clinical translatability of this unconventional cellular mechanism remained poorly understood. Here, we summarize and discuss current concepts of the mechanisms and disease relevance of NET formation. © 2018 Stichting European Society for Clinical Investigation Journal Foundation.
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Development of wavelet analysis tools for turbulence
NASA Technical Reports Server (NTRS)
Bertelrud, A.; Erlebacher, G.; Dussouillez, PH.; Liandrat, M. P.; Liandrat, J.; Bailly, F. Moret; Tchamitchian, PH.
1992-01-01
Presented here is the general framework and the initial results of a joint effort to derive novel research tools and easy to use software to analyze and model turbulence and transition. Given here is a brief review of the issues, a summary of some basic properties of wavelets, and preliminary results. Technical aspects of the implementation, the physical conclusions reached at this time, and current developments are discussed.
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Faupel-Badger, Jessica M.; van Bemmel, Dana M.; Wiest, Jonathan S.; Nelson, David E.
2012-01-01
The Summer Curriculum in Cancer Prevention has been sponsored by the National Cancer Institute’s Cancer Prevention Fellowship Program for over two decades. This curriculum includes a four-week course entitled “Principles and Practice of Cancer Prevention and Control.” The ultimate goal of this course is to present the most current cancer prevention research to a diverse workforce of researchers and practitioners eager to address the current challenges in this field. The course covers the current status of cancer prevention research and practice, ranging from epidemiology and clinical practice, and from basic to behavioral science research. It is comprised of lectures grouped into nine modules representing broad and specific topics relevant to cancer prevention. Course participants come from a broad cross-section of career stages, professions, and research interests, and are from across the United States and other countries. Over time and in response to feedback from participants, the course has developed to meet the needs and expectations of this diverse audience, and may serve as a model for those interested in cancer prevention education and training in other countries. PMID:21785976
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The NASA Materials Science Research Program: It's New Strategic Goals and Opportunities
NASA Technical Reports Server (NTRS)
Schlagheck, Ronald A.; Stagg, Elizabeth
2004-01-01
In the past year, the NASA s Office of Biological and Physical Research (OBPR) has formulated a long term plan to perform strategical and fundamental research bringing together physics, chemistry, biology, and engineering to solve problems needed for current and future agency mission goals. Materials Science is one of basic disciplines within the Enterprise s Division of Physical Sciences Research. The Materials Science Program participates to utilize effective use of International Space Station (ISS) and various world class ground laboratory facilities to solve new scientific and technology questions and transfer these results for public and agency benefits. The program has recently targeted new investigative research in strategic areas necessary to expand NASA knowledge base for exploration of the universe and some of these experiments will need access to the microgravity of space. The program is implementing a wide variety of traditional ground and flight based research related types of fundamental science related to materials crystallization, fundamental processing, and properties characterization in order to obtain basic understanding of various phenomena effects and relationships to the structures, processing, and properties of materials. , In addition new initiatives in radiation protection, materials for propulsion and In-space fabrication and repair focus on research helping the agency solve problems needed for future transportation into the solar system. A summary of the types and sources for this research is presented including those experiments planned for a low gravity environment. Areas to help expand the science basis for NASA future missions are described. An overview of the program is given including the scope of the current and future NASA Research Announcements with emphasis on new materials science initiatives. A description of the planned flight experiments to be conducted on the International Space Station program along with the planned facility class Materials Science Research Rack (MSRR) and Microgravity Glovebox (MSG) type investigations. Some initial results from the first three materials experiments are given.
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High resolution infrared datasets useful for validating stratospheric models
NASA Technical Reports Server (NTRS)
Rinsland, Curtis P.
1992-01-01
An important objective of the High Speed Research Program (HSRP) is to support research in the atmospheric sciences that will improve the basic understanding of the circulation and chemistry of the stratosphere and lead to an interim assessment of the impact of a projected fleet of High Speed Civil Transports (HSCT's) on the stratosphere. As part of this work, critical comparisons between models and existing high quality measurements are planned. These comparisons will be used to test the reliability of current atmospheric chemistry models. Two suitable sets of high resolution infrared measurements are discussed.
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Energy systems equipment market research in the Philippines. Foreign market survey report
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1979-05-01
The market research was undertaken to study the present and potential US share of the market in the Philippines for energy systems equipment; to examine growth trends in the Philippines end-user industries over the next few years; to identify specific product categories that offer the most promising export potential for US companies; and to provide basic data which will assist US suppliers in determining current and potential sales and marketing opportunities. The trade promotional and marketing techniques which are likely to suceed in the Philippines were also reviewed.
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Research requirements to reduce civil helicopter life cycle cost
NASA Technical Reports Server (NTRS)
Blewitt, S. J.
1978-01-01
The problem of the high cost of helicopter development, production, operation, and maintenance is defined and the cost drivers are identified. Helicopter life cycle costs would decrease by about 17 percent if currently available technology were applied. With advanced technology, a reduction of about 30 percent in helicopter life cycle costs is projected. Technological and managerial deficiencies which contribute to high costs are examined, basic research and development projects which can reduce costs include methods for reduced fuel consumption; improved turbine engines; airframe and engine production methods; safety; rotor systems; and advanced transmission systems.
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LANDSAT-4 TM image data quality analysis for energy-related applications
NASA Technical Reports Server (NTRS)
Wukelic, G. E.; Foote, H. P.
1983-01-01
LANDSAT-4 Thematic Mapper (TM) data performance and utility characteristics from an energy research and technology perspective is evaluated. The program focuses on evaluating applicational implications of using such data, in combination with other digital data, for current and future energy research and technology activities. Prime interest is in using TM data for siting, developing and operating federal energy facilities. Secondary interests involve the use of such data for resource exploration, environmental monitoring and basic scientific initiatives such as in support of the Continental Scientific Drilling Program.
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Primary care research--a blueprint for action for Singapore.
Chuan, T N; Gan, G L
2001-01-01
Primary care research, hitherto overshadowed by research in the tertiary institutions, lacks impetus due to image, limitations of resources and poor infrastructure. This article looks into the current state of research development and the barriers. These hurdles can be overcome by a paradigm shift through the initiation of regular research meetings, training, infrastructure support and a collaborative research network to optimize time and resources. This will open the door to a wide field of primary care research, from basic, clinical research to health service and health system analysis and evaluation. Family physicians can tap on this opportunity to sharpen their critical appraisal skills through research, which can form an integral part of their continuous professional development. A network of pro-research family physicians will foster a vibrant research culture and pave the way to a renaissance of primary care research.
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IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG).
Hari, Riitta; Baillet, Sylvain; Barnes, Gareth; Burgess, Richard; Forss, Nina; Gross, Joachim; Hämäläinen, Matti; Jensen, Ole; Kakigi, Ryusuke; Mauguière, François; Nakasato, Nobukatzu; Puce, Aina; Romani, Gian-Luca; Schnitzler, Alfons; Taulu, Samu
2018-04-17
Magnetoencephalography (MEG) records weak magnetic fields outside the human head and thereby provides millisecond-accurate information about neuronal currents supporting human brain function. MEG and electroencephalography (EEG) are closely related complementary methods and should be interpreted together whenever possible. This manuscript covers the basic physical and physiological principles of MEG and discusses the main aspects of state-of-the-art MEG data analysis. We provide guidelines for best practices of patient preparation, stimulus presentation, MEG data collection and analysis, as well as for MEG interpretation in routine clinical examinations. In 2017, about 200 whole-scalp MEG devices were in operation worldwide, many of them located in clinical environments. Yet, the established clinical indications for MEG examinations remain few, mainly restricted to the diagnostics of epilepsy and to preoperative functional evaluation of neurosurgical patients. We are confident that the extensive ongoing basic MEG research indicates potential for the evaluation of neurological and psychiatric syndromes, developmental disorders, and the integrity of cortical brain networks after stroke. Basic and clinical research is, thus, paving way for new clinical applications to be identified by an increasing number of practitioners of MEG. Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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Materials Requirements for Advanced Propulsion Systems
NASA Technical Reports Server (NTRS)
Whitaker, Ann F.; Cook, Mary Beth; Clinton, R. G., Jr.
2005-01-01
NASA's mission to "reach the Moon and Mars" will be obtained only if research begins now to develop materials with expanded capabilities to reduce mass, cost and risk to the program. Current materials cannot function satisfactorily in the deep space environments and do not meet the requirements of long term space propulsion concepts for manned missions. Directed research is needed to better understand materials behavior for optimizing their processing. This research, generating a deeper understanding of material behavior, can lead to enhanced implementation of materials for future exploration vehicles. materials providing new approaches for manufacture and new options for In response to this need for more robust materials, NASA's Exploration Systems Mission Directorate (ESMD) has established a strategic research initiative dedicated to materials development supporting NASA's space propulsion needs. The Advanced Materials for Exploration (AME) element directs basic and applied research to understand material behavior and develop improved materials allowing propulsion systems to operate beyond their current limitations. This paper will discuss the approach used to direct the path of strategic research for advanced materials to ensure that the research is indeed supportive of NASA's future missions to the moon, Mars, and beyond.
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The Relationship between Basic and Applied Research in Universities
ERIC Educational Resources Information Center
Bentley, Peter James; Gulbrandsen, Magnus; Kyvik, Svein
2015-01-01
What is the central research activity in modern universities? This paper uses a comprehensive survey among individuals from 15 countries to map differences in orientation towards basic/fundamental research, applied/practical research and a combination of the two. Despite some claims in the literature that basic research is no longer a…
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16 CFR 305.8 - Submission of data.
Code of Federal Regulations, 2010 CFR
2010-01-01
... input voltage and frequency; (vi) Ballast efficacy factor; and (vii) Type (F40T12, F96T12 or F96T12HO..., heat pumps, furnaces, ceiling fans, and pool heaters) for each basic model in current production..., for each basic model in current production: the brand name; the model numbers for each basic model...
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Can Basic Research on Children and Families Be Useful for the Policy Process?
ERIC Educational Resources Information Center
Moore, Kristin A.
Based on the assumption that basic science is the crucial building block for technological and biomedical progress, this paper examines the relevance for public policy of basic demographic and behavioral sciences research on children and families. The characteristics of basic research as they apply to policy making are explored. First, basic…
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32 CFR 37.1240 - Basic research.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 32 National Defense 1 2013-07-01 2013-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...
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32 CFR 37.1240 - Basic research.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 32 National Defense 1 2011-07-01 2011-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...
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32 CFR 37.1240 - Basic research.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 32 National Defense 1 2014-07-01 2014-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...
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32 CFR 37.1240 - Basic research.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 32 National Defense 1 2010-07-01 2010-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...
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32 CFR 37.1240 - Basic research.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 32 National Defense 1 2012-07-01 2012-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...
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Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.
Burd, Christin E; Gill, Matthew S; Niedernhofer, Laura J; Robbins, Paul D; Austad, Steven N; Barzilai, Nir; Kirkland, James L
2016-11-01
Through the progress of basic science research, fundamental mechanisms that contribute to age-related decline are being described with increasing depth and detail. Although these efforts have identified new drug targets and compounds that extend life span in model organisms, clinical trials of therapeutics that target aging processes remain scarce. Progress in aging research is hindered by barriers associated with the translation of basic science discoveries into the clinic. This report summarizes discussions held at a 2014 Geroscience Network retreat focused on identifying hurdles that currently impede the preclinical development of drugs targeting fundamental aging processes. From these discussions, it was evident that aging researchers have varied perceptions of the ideal preclinical pipeline. To forge a clear and cohesive path forward, several areas of controversy must first be resolved and new tools developed. Here, we focus on five key issues in preclinical drug development (drug discovery, lead compound development, translational preclinical biomarkers, funding, and integration between researchers and clinicians), expanding upon discussions held at the Geroscience Retreat and suggesting areas for further research. By bringing these findings to the attention of the aging research community, we hope to lay the foundation for a concerted preclinical drug development pipeline. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America.
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Stahl, Andreas; Smith, Lois E.H.
2010-01-01
Vision research has often led to significant advances in our understanding of biology. There has also been particular success in translating basic research in the eye into breakthrough clinical therapies that mark important milestones for ophthalmology and also for medical research. Anti-VEGF therapy for age-related macular degeneration was named as one of the top ten science advancements of the year 2006. Only two years later, successful transfer of the RPE65 gene into retinal pigment epithelium of patients with Leber congenital amaurosis was noted as one of the most important clinical applications of gene therapy. The articles in this Review series outline current developments in vision research and highlight its continued importance in ophthalmology and medicine. PMID:20811156
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El-Shinawi, Mohamed; Mohamed, Karim Osama; Fouad, Yousef Ahmed; Fahmy, Yara Mohamed; Asar, Hadeel Abdulwahed; Khalil, Mohamed Gomaa; Anestidou, Lida; El-Kamary, Samer S; Mohamed, Mona Mostafa
2016-01-01
This is a quasi-experimental pre-post assessment study utilizing an anonymous self-administered questionnaire to assess Egyptian medical students' awareness about responsible conduct of research (RCR) and research ethics. Students' were assessed before and after an RCR awareness campaign. Our results showed that most of the pre-campaign respondents were not familiar with the basic principles and terms of RCR. An increase in the awareness about RCR across all discussed topics was noted following the campaign. We concluded that an educational awareness campaign is effective in increasing medical students' awareness about RCR and should be incorporated into current medical school curricula in Egypt.
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Toward a Modern Science of Obesity at Washington University: How We Do It and What is the Payoff?
Colditz, Graham A; Gehlert, Sarah; Bowen, Deborah J; Carson, Kenneth; Hovmand, Peter S; Lee, Jung Ae; Moley, Kelle H
2016-07-01
In our Cancer Prevention Program at Washington University in Saint Louis (WUSTL), we have made extraordinary efforts to create the kind of cancer prevention and control program that is both translational and transdisciplinary in nature, to accelerate the march from basic discoveries to population change. Here we present an overview of our obesity-related research currently ongoing in our Center, paying particular attention to both the translational- transdisciplinary process and to community-based participatory research. We end with our future directions for improving obesity-related cancer outcomes research. Cancer Prev Res; 9(7); 503-8. ©2016 AACR. ©2016 American Association for Cancer Research.
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Cranial electrotherapy stimulation for the treatment of depression.
Gunther, Mary; Phillips, Kenneth D
2010-11-01
More prevalent in women than men, clinical depression affects approximately 15 million American adults in a given year. Psychopharmaceutical therapy accompanied by psychotherapy and wellness interventions (e.g., nutrition, exercise, counseling) is effective in 80% of diagnosed cases. A lesser known adjunctive therapy is that of cranial electrotherapy stimulation (CES). The major hypothesis for the use of CES in depression is that it may reset the brain to pre-stress homeostasis levels. It is conjectured that the pulsed electrical currents emitted by cranial electrical stimulators affect changes in the limbic system, the reticular activating system, and/or the hypothalamus that result in neurotransmitter secretion and downstream hormone production. While evidence is good for applied research, basic research about the mechanisms of action for CES remains in its infancy. A review of the literature provides an overview of current research findings and implications for clinical mental health practice.
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Ethics and regulation in organ procurement research.
Ackerman, Terrence F; Winsett, Rebecca P
2002-12-01
This article explores the role of ethics and regulation in human research conducted by organ procurement agencies; basic ethical principles for human research are outlined. Organ procurement agencies are not required to observe federal regulations; however, voluntary adherence will ensure that procurement research is conducted according to current standards of ethical practice. Although most organ procurement research will qualify for exempt status, this determination should be made by an institutional review board. Even if studies qualify for exempt status, there is a moral presumption that informed consent should be sought, unless certain narrow conditions for waiver of consent are satisfied. Finally, when future research utilizing organ procurement records is anticipated, procurement coordinators should provide sufficiently detailed information to families about such plans to permit their advance informed consent to research activities.
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Current therapeutic strategies for premature ejaculation and future perspectives
Xin, Zhong-Cheng; Zhu, Yi-Chen; Yuan, Yi-Ming; Cui, Wan-Shou; Jin, Zhe; Li, Wei-Ren; Liu, Tao
2011-01-01
Premature ejaculation (PE) is a common sexual disorder in men that is mediated by disturbances in the peripheral and central nervous systems. Although all pharmaceutical treatments for PE are currently used ‘off-label', some novel oral agents and some newer methods of drug administration now provide important relief to PE patients. However, the aetiology of this condition has still not been unified, primarily because of the lack of a standard animal model for basic research and the absence of a widely accepted definition and assessment tool for evidence-based clinical studies in patients with PE. In this review, we focus on the current therapeutic strategies and future treatment perspectives for PE. PMID:21532601
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Vollmar, Horst Christian; Georgieff, Peter; Bührlen, Bernhard
2010-01-01
Clinical research is a central link in the development chain of new treatment methods; scientifically, it belongs between basic science and health services research. It spans from the first application of a new substance or device in humans to the main proofs of its efficacy and safety. Economically speaking, it absorbs almost half of the total expenditures for the research and development of a new drug and represents a significant factor in the labour market for researchers and study personnel. Also, through participation in clinical trials, patients gain early access to new treatment methods, while on the other hand they are placed at higher risk for undesired side effects. Politics have taken significant steps to strengthen clinical research, but the pharmaceutical industry continues to complain about competitive disadvantages. Despite internationally recognised and, to a large extent, legally codified guidelines there are still significant national differences in implementation. In addition, traditional practices in clinical research are challenged by novel, mainly biotechnological therapeutic methods for which our current knowledge base is rather limited and which therefore entail a higher risk for patients or trial participants. The following paper summarises a report for the Office of Technology Assessment at the German Federal Parliament (TAB). Based on current regulations, scientific literature and expert interviews, current challenges and solution strategies for clinical research will be analysed in terms of an international comparison.
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The use of fish models to study human neurological disorders.
Matsui, Hideaki
2017-07-01
Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseases and psychiatric disorders. This review summarizes the advantages and disadvantages of using fish for neuropsychiatric research using primarily our own studies as examples. We discuss how fish belong to a class of vertebrates, are feasible for imaging, and include diverse species with multiple research possibilities yet to be discovered. Copyright © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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[How to write an andrological paper: standardization, mechanics and techniques].
Huang, Yu-Feng; Lu, Jin-Chun
2010-12-01
Andrological research papers not only reflect the current status and academic level of andrology, but also constitute an important communication platform for researchers and clinicians engaged in this field and contribute significantly to the development of andrology. It would be made easier to write a high-quality andrological paper once the author observes the basic requirements of research papers, adheres to the use of standard scientific terminology, knows the special writing mechanics, and equips himself with some essential writing techniques. Based on the long experience of editorship, we present a detailed introduction of the standardization, mechanics and techniques of writing an andrological paper.
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Continued Viability of Universities as Centers for Basic Research.
ERIC Educational Resources Information Center
Carter, Lisle C., Jr.; And Others
The findings and 13 recommendations of a NSF Advisory Council task force that evaluated universities as centers of basic research are presented. Listed are the major strengths of universities as centers for basic research (including continuity and tradition, freedom of research, interactions among disciplines) and such threats to their viability…
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Liquid-Crystal-Enabled Active Plasmonics: A Review
Si, Guangyuan; Zhao, Yanhui; Leong, Eunice Sok Ping; Liu, Yan Jun
2014-01-01
Liquid crystals are a promising candidate for development of active plasmonics due to their large birefringence, low driving threshold, and versatile driving methods. We review recent progress on the interdisciplinary research field of liquid crystal based plasmonics. The research scope of this field is to build the next generation of reconfigurable plasmonic devices by combining liquid crystals with plasmonic nanostructures. Various active plasmonic devices, such as switches, modulators, color filters, absorbers, have been demonstrated. This review is structured to cover active plasmonic devices from two aspects: functionalities and driven methods. We hope this review would provide basic knowledge for a new researcher to get familiar with the field, and serve as a reference for experienced researchers to keep up the current research trends. PMID:28788515
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Basic Blue Skies Research in the UK: Are we losing out?
Linden, Belinda
2008-01-01
Background The term blue skies research implies a freedom to carry out flexible, curiosity-driven research that leads to outcomes not envisaged at the outset. This research often challenges accepted thinking and introduces new fields of study. Science policy in the UK has given growing support for short-term goal-oriented scientific research projects, with pressure being applied on researchers to demonstrate the future application of their work. These policies carry the risk of restricting freedom, curbing research direction, and stifling rather than stimulating the creativity needed for scientific discovery. Methods This study tracks the tortuous routes that led to three major discoveries in cardiology. It then investigates the constraints in current research, and opportunities that may be lost with existing funding processes, by interviewing selected scientists and fund providers for their views on curiosity-driven research and the freedom needed to allow science to flourish. The transcripts were analysed using a grounded theory approach to gather recurrent themes from the interviews. Results The results from these interviews suggest that scientists often cannot predict the future applications of research. Constraints such as lack of scientific freedom, and a narrow focus on relevance and accountability were believed to stifle the discovery process. Although it was acknowledged that some research projects do need a clear and measurable framework, the interviewees saw a need for inquisitive, blue skies research to be managed in a different way. They provided examples of situations where money allocated to 'safe' funding was used for more innovative research. Conclusion This sample of key UK scientists and grant providers acknowledge the importance of basic blue skies research. Yet the current evaluation process often requires that scientists predict their likely findings and estimate short-term impact, which does not permit freedom of research direction. There is a vital need for prominent scientists and for universities to help the media, the public, and policy makers to understand the importance of innovative thought along with the need for scientists to have the freedom to challenge accepted thinking. Encouraging an avenue for blue skies research could have immense influence over future scientific discoveries. PMID:18312612
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Basic Blue Skies Research in the UK: Are we losing out?
Linden, Belinda
2008-02-29
The term blue skies research implies a freedom to carry out flexible, curiosity-driven research that leads to outcomes not envisaged at the outset. This research often challenges accepted thinking and introduces new fields of study. Science policy in the UK has given growing support for short-term goal-oriented scientific research projects, with pressure being applied on researchers to demonstrate the future application of their work. These policies carry the risk of restricting freedom, curbing research direction, and stifling rather than stimulating the creativity needed for scientific discovery. This study tracks the tortuous routes that led to three major discoveries in cardiology. It then investigates the constraints in current research, and opportunities that may be lost with existing funding processes, by interviewing selected scientists and fund providers for their views on curiosity-driven research and the freedom needed to allow science to flourish. The transcripts were analysed using a grounded theory approach to gather recurrent themes from the interviews. The results from these interviews suggest that scientists often cannot predict the future applications of research. Constraints such as lack of scientific freedom, and a narrow focus on relevance and accountability were believed to stifle the discovery process. Although it was acknowledged that some research projects do need a clear and measurable framework, the interviewees saw a need for inquisitive, blue skies research to be managed in a different way. They provided examples of situations where money allocated to 'safe' funding was used for more innovative research. This sample of key UK scientists and grant providers acknowledge the importance of basic blue skies research. Yet the current evaluation process often requires that scientists predict their likely findings and estimate short-term impact, which does not permit freedom of research direction. There is a vital need for prominent scientists and for universities to help the media, the public, and policy makers to understand the importance of innovative thought along with the need for scientists to have the freedom to challenge accepted thinking. Encouraging an avenue for blue skies research could have immense influence over future scientific discoveries.
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The Rogowski Coil Sensor in High Current Application: A Review
NASA Astrophysics Data System (ADS)
Nazmy Nanyan, Ayob; Isa, Muzamir; Hamid, Haziah Abdul; Nur Khairul Hafizi Rohani, Mohamad; Ismail, Baharuddin
2018-03-01
Rogowski coil is used for measuring the alternating current (AC) and high-speed current pulses. However, the technology makes the Rogowski coil (RC) come out with more improvement, modification and until today it’s still being studied for the new application. The Rogowski coil has a few advantages compared to the high frequency current transformer (HFCT). A brief review on the basic theory and the application of Rogowski coil as a current sensor measurement that been done by previous researchers are presented and discussed in this paper. Additionally, the review also focused on the capability of Rogowski coil for high current sensor measurement and their application for fault detection, over voltage current sensor, lightning current sensor and high impulse current detection. The experimental set up, techniques and measurement parameters in models also been discussed. Finally, a brief review on the performance analysis of current sensor measurement of Rogowski coil likes sensitivity, the maximum and current detection which could be used as a guideline to another researcher in order to develop an advanced RC as high current sensor in future is presented. This review reveal that the RC has a very good performance in high current sensor detection in term of sensitivity which is up to a few nanosecond, higher bandwidth, excellent in detection of high fault and also could measuring lightning current up to 400kA and has many advantages compare to conventional current transformer(CT).
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Code of Federal Regulations, 2010 CFR
2010-01-01
... basic State Factor (SF). The data sources used for each criteria is believed to be the most current and... given the criteria. The transition formula first checks whether the current year's basic formula... year's BFA). EC14NO91.000 If the current year's State BFA is not within this transition range, the...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-15
... for OMB Review; Comment Request; Current Population Survey--Basic Labor Force ACTION: Notice. SUMMARY... collection request (ICR) titled, ``Current Population Survey--Basic Labor Force,'' to the Office of Management and Budget (OMB) for review and approval for continued use in accordance with the Paperwork...
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Rainwater, Julie A.; Chiamvimonvat, Nipavan; Bonham, Ann C.; Robbins, John A.; Henderson, Stuart; Meyers, Frederick J.
2013-01-01
Abstract There is a need for successful models of how to recruit, train, and retain bench scientists at the earliest stages of their careers into translational research. One recent, promising model is the University of California Davis Howard Hughes Medical Institute Integrating Medicine into Basic Science (HHMI‐IMBS) program, part of the HHMI Med into Grad initiative. This paper outlines the HHMI‐IMBS program's logic, design, and curriculum that guide the goal of research that moves from bedside to bench. That is, a curriculum that provides graduate students with guided translational training, clinical exposure, team science competencies, and mentors from diverse disciplines that will advance the students careers in clinical translational research and re‐focusing of research to answer clinical dilemmas. The authors have collected data on 55 HHMI‐IMBS students to date. Many of these students are still completing their graduate work. In the current study the authors compare the initial two cohorts (15 students) with a group of 29 control students to examine the program success and outcomes. The data indicate that this training program provides an effective, adaptable model for training future translational researchers. HHMI‐IMBS students showed improved confidence in conducting translational research, greater interest in a future translational career, and higher levels of research productivity and collaborations than a comparable group of predoctoral students. PMID:24127920
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Izuhara, Kenji; Ohta, Shoichiro; Arima, Kazuhiko; Suzuki, Shoichi; Inamitsu, Masako; Yamamoto, Ken-ichi
2013-10-01
Biomarkers are generally important for the treatment of patients from the points of diagnosis of disease, assessment of cure, assessment of prognosis such as metastasis or recurrence, prevention of disease, and prediction of drug efficacy. Currently it is well accepted that allergic diseases such as bronchial asthma and atopic dermatitis are not single diseases, but syndromes encompassing different diseases entities. Therefore, it is important to cluster allergic disease patients to assess prognosis or the choice of therapeutic drugs, and useful biomarkers are required for these purposes. Periostin, an extracellular matrix protein, has recently emerged as a biomarker useful for clustering asthma patients. We further found that periostin plays an important role in allergic inflammation and based on this finding we are now developing therapeutic agents targeting periostin against allergic diseases. Since periostin is involved in the pathogenesis of various inflammatory diseases in addition to allergic diseases, such diagnostics and therapeutic agents can be applied to many inflammatory diseases. In this article, we describe the history of periostin research and our application of basic research to the development of diagnostics and therapeutic agents against inflammatory diseases.
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An approximate methods approach to probabilistic structural analysis
NASA Technical Reports Server (NTRS)
Mcclung, R. C.; Millwater, H. R.; Wu, Y.-T.; Thacker, B. H.; Burnside, O. H.
1989-01-01
A major research and technology program in Probabilistic Structural Analysis Methods (PSAM) is currently being sponsored by the NASA Lewis Research Center with Southwest Research Institute as the prime contractor. This program is motivated by the need to accurately predict structural response in an environment where the loadings, the material properties, and even the structure may be considered random. The heart of PSAM is a software package which combines advanced structural analysis codes with a fast probability integration (FPI) algorithm for the efficient calculation of stochastic structural response. The basic idea of PAAM is simple: make an approximate calculation of system response, including calculation of the associated probabilities, with minimal computation time and cost, based on a simplified representation of the geometry, loads, and material. The deterministic solution resulting should give a reasonable and realistic description of performance-limiting system responses, although some error will be inevitable. If the simple model has correctly captured the basic mechanics of the system, however, including the proper functional dependence of stress, frequency, etc. on design parameters, then the response sensitivities calculated may be of significantly higher accuracy.
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Dengue: Knowledge gaps, unmet needs and research priorities
Katzelnick, Leah C.; Coloma, Josefina; Harris, Eva
2018-01-01
Summary Dengue virus (DENV) is a mosquito-borne pathogen that causes up to ~100 million dengue cases each year, placing a major public health, social and economic burden on numerous low- and middle-income countries (LMICs). Major advances by scientists, vaccine developers, and affected communities are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Such research has highlighted further questions about both the basic understanding of dengue and efforts to develop new tools. We discuss existing approaches to dengue diagnostics, disease prognosis, surveillance, and vector control in LMICs as well as potential consequences of vaccine introduction. We also summarize current knowledge and recent insights into dengue epidemiology, immunology, and pathogenesis, and their implications for understanding natural infection and current and future vaccines. PMID:28185868
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Olfactory epithelium: Cells, clinical disorders, and insights from an adult stem cell niche
Choi, Rhea
2018-01-01
Disorders causing a loss of the sense of smell remain a therapeutic challenge. Basic research has, however, greatly expanded our knowledge of the organization and function of the olfactory system. This review describes advances in our understanding of the cellular components of the peripheral olfactory system, specifically the olfactory epithelium in the nose. The article discusses recent findings regarding the mechanisms involved in regeneration and cellular renewal from basal stem cells in the adult olfactory epithelium, considering the strategies involved in embryonic olfactory development and insights from research on other stem cell niches. In the context of clinical conditions causing anosmia, the current view of adult olfactory neurogenesis, tissue homeostasis, and failures in these processes is considered, along with current and future treatment strategies. Level of Evidence NA PMID:29492466
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Jones, Shawn C T; Neblett, Enrique W
2017-01-01
Research on racism-related stress and racial-ethnic protective factors represents an important enterprise for optimizing the mental health of African American and other racial and ethnic minority youth. However, there has been a relative dearth of work on these factors in the clinical psychology research literature, and more work is needed in outlets such as these. To this end, the current article adopts a developmental psychopathology framework and uses recent empirical findings to outline our current understanding of racism-related stress and racial-ethnic protective factors (i.e., racial identity, racial socialization, Africentric worldview) for African American youth. We then provide nine recommendations-across basic, applied, and broader/cross-cutting research lines-that we prioritize as essential to advancing the future scientific investigation of this crucial research agenda. Within and across these recommendations, we issue a charge to researchers and clinicians alike, with the ultimate goal of alleviating the negative mental health impact that racism-related stress can have on the well-being and mental health of African American and other racial and ethnic minority youth.
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Sustainable Transportation Basics | Transportation Research | NREL
Transportation Basics Sustainable Transportation Basics Compare Vehicle Technologies 3-D introduction to sustainable transportation. NREL research supports development of electric, hybrid, hydrogen
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Quantitative proteomics in the field of microbiology.
Otto, Andreas; Becher, Dörte; Schmidt, Frank
2014-03-01
Quantitative proteomics has become an indispensable analytical tool for microbial research. Modern microbial proteomics covers a wide range of topics in basic and applied research from in vitro characterization of single organisms to unravel the physiological implications of stress/starvation to description of the proteome content of a cell at a given time. With the techniques available, ranging from classical gel-based procedures to modern MS-based quantitative techniques, including metabolic and chemical labeling, as well as label-free techniques, quantitative proteomics is today highly successful in sophisticated settings of high complexity such as host-pathogen interactions, mixed microbial communities, and microbial metaproteomics. In this review, we will focus on the vast range of techniques practically applied in current research with an introduction of the workflows used for quantitative comparisons, a description of the advantages/disadvantages of the various methods, reference to hallmark publications and presentation of applications in current microbial research. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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John, T A
2011-06-01
Basic science departments in academic medical centres are influenced by changes that are commonly directed at medical education and financial gain. Some of such changes may have been detrimental to or may have enhanced basic science education. They may have determined basic science research focus or basic science research methods. However, there is lack of research on the educational process in the basic sciences including training of PhD's while there is ample research on medical education pertaining to training of medical doctors. The author here identifies, from university websites and available literature, some forces that have driven teaching and research focus and methods in state-of-the-arts academic medical centres in recent times with a view of seeing through their possible influences on basic science education and research, using the United States of America as an example. The "forces" are: Changes in medical schools; Medical educational philosophies: problem based learning, evidence based medicine, cyberlearning and self-directed learning; Shifting impressions of the value of basic sciences in medical schools; Research trends in Basic Sciences: role of antivivisectionists, alternative experimentations, explosion of molecular and cell biology; Technological advancements; Commercialization of research; and Funding agencies. The author encourages African leaders in academia to pay attention to such forces as the leadership seeks to raise African Universities as centres of knowledge that have a major role in acquiring, preserving, imparting, and utilizing knowledge.
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Hubble trial: time to stick to basics for treatment of haemorrhoids?
Brown, S R
2017-01-01
The results of the Hubble trial, a randomised controlled trial comparing haemorrhoidal artery ligation with rubber band ligation for early-grade prolapsing haemorrhoids, are discussed. The difficulties in defining treatment success are debated along with the trial design highlighting the pitfalls of previous research. A finding that haemorrhoidal artery ligation is not necessarily superior to cheap alternatives has implications for current practice and future commissioning of surgeons.
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Study on various elements of the geosciences with respect to space technology
NASA Technical Reports Server (NTRS)
Head, J. W., III
1981-01-01
The utility of data acquired in space for both basic and applied studies of the geology of the Earth was evaluated. Focus was placed upon the gaps in the current ability to make effective use of remote sensing technology within the Earth sciences. A long range plan is presented for future research that involves an appropriate balance between the development and application of space techniques.
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Military Compensation: Past, Present and Future. Volume 1. Executive Summary.
1976-01-01
Chapter 3 provides an overview of the current military compen- sation system -- i.e., the military pay and allowances system. The major subsystems to...research efforts produced processes for control of shrinkageof wool fabrics. In the US textile industry, wooliteis are nowtreated by these processes...led to development of .4,4continuous dyeing. Ilodern dyeing facilities of large textile • actories throughout the world trace their basic technology
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ERIC Educational Resources Information Center
Coursen, David
Estimates of the precise costs of school vandalism vary widely, but the seriousness of the problem is beyond dispute. It is possible to get a general idea of the nature and motivation of most vandals and, in doing so, begin to understand the problem and devise solutions for it. There are two basic approaches to vandalism prevention. Currently, as…
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Nonprofit foundations spur translational research.
Zaratin, Paola; Battaglia, Mario Alberto; Abbracchio, Maria P
2014-11-01
Every year, hundreds of promising basic discoveries in the pharmacological field are lost and will never have a chance to be exploited for patients due to difficulties in clinical translation. This is especially true for most neurodegenerative disorders lacking disease-modifying therapies. Here we present the current scenario and our vision of a 'collective-impact' multistakeholder approach to expedite the development of new drugs. Copyright © 2014 Elsevier Ltd. All rights reserved.
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Multilayer scaffolds in orthopaedic tissue engineering.
Atesok, Kivanc; Doral, M Nedim; Karlsson, Jon; Egol, Kenneth A; Jazrawi, Laith M; Coelho, Paulo G; Martinez, Amaury; Matsumoto, Tomoyuki; Owens, Brett D; Ochi, Mitsuo; Hurwitz, Shepard R; Atala, Anthony; Fu, Freddie H; Lu, Helen H; Rodeo, Scott A
2016-07-01
The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration. Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces. In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications. Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.
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32 CFR Appendix A to Part 272 - Principles for the Conduct and Support of Basic Research
Code of Federal Regulations, 2011 CFR
2011-07-01
... those agencies' investments as appropriate. 5. Merit review is used to select basic research projects... Research A Appendix A to Part 272 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE...
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Research-Based Reading Instruction in an Adult Basic Education Program
ERIC Educational Resources Information Center
Perin, Dolores; Greenberg, Daphne
2007-01-01
There is a growing emphasis in adult basic education on research-based reading instruction. Using Kruidenier's (2002) framework of principles and trends, we describe research-based techniques found during a visit to an adult basic education program. We also describe how the program moved to research-based instruction, and the factors that seem…
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Darquenne, Chantal; Fleming, John S; Katz, Ira; Martin, Andrew R; Schroeter, Jeffry; Usmani, Omar S; Venegas, Jose; Schmid, Otmar
2016-04-01
Development of a new drug for the treatment of lung disease is a complex and time consuming process involving numerous disciplines of basic and applied sciences. During the 2015 Congress of the International Society for Aerosols in Medicine, a group of experts including aerosol scientists, physiologists, modelers, imagers, and clinicians participated in a workshop aiming at bridging the gap between basic research and clinical efficacy of inhaled drugs. This publication summarizes the current consensus on the topic. It begins with a short description of basic concepts of aerosol transport and a discussion on targeting strategies of inhaled aerosols to the lungs. It is followed by a description of both computational and biological lung models, and the use of imaging techniques to determine aerosol deposition distribution (ADD) in the lung. Finally, the importance of ADD to clinical efficacy is discussed. Several gaps were identified between basic science and clinical efficacy. One gap between scientific research aimed at predicting, controlling, and measuring ADD and the clinical use of inhaled aerosols is the considerable challenge of obtaining, in a single study, accurate information describing the optimal lung regions to be targeted, the effectiveness of targeting determined from ADD, and some measure of the drug's effectiveness. Other identified gaps were the language and methodology barriers that exist among disciplines, along with the significant regulatory hurdles that need to be overcome for novel drugs and/or therapies to reach the marketplace and benefit the patient. Despite these gaps, much progress has been made in recent years to improve clinical efficacy of inhaled drugs. Also, the recent efforts by many funding agencies and industry to support multidisciplinary networks including basic science researchers, R&D scientists, and clinicians will go a long way to further reduce the gap between science and clinical efficacy.
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Fleming, John S.; Katz, Ira; Martin, Andrew R.; Schroeter, Jeffry; Usmani, Omar S.; Venegas, Jose
2016-01-01
Abstract Development of a new drug for the treatment of lung disease is a complex and time consuming process involving numerous disciplines of basic and applied sciences. During the 2015 Congress of the International Society for Aerosols in Medicine, a group of experts including aerosol scientists, physiologists, modelers, imagers, and clinicians participated in a workshop aiming at bridging the gap between basic research and clinical efficacy of inhaled drugs. This publication summarizes the current consensus on the topic. It begins with a short description of basic concepts of aerosol transport and a discussion on targeting strategies of inhaled aerosols to the lungs. It is followed by a description of both computational and biological lung models, and the use of imaging techniques to determine aerosol deposition distribution (ADD) in the lung. Finally, the importance of ADD to clinical efficacy is discussed. Several gaps were identified between basic science and clinical efficacy. One gap between scientific research aimed at predicting, controlling, and measuring ADD and the clinical use of inhaled aerosols is the considerable challenge of obtaining, in a single study, accurate information describing the optimal lung regions to be targeted, the effectiveness of targeting determined from ADD, and some measure of the drug's effectiveness. Other identified gaps were the language and methodology barriers that exist among disciplines, along with the significant regulatory hurdles that need to be overcome for novel drugs and/or therapies to reach the marketplace and benefit the patient. Despite these gaps, much progress has been made in recent years to improve clinical efficacy of inhaled drugs. Also, the recent efforts by many funding agencies and industry to support multidisciplinary networks including basic science researchers, R&D scientists, and clinicians will go a long way to further reduce the gap between science and clinical efficacy. PMID:26829187
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The current state-of-the-art of spinal cord imaging: Methods
Stroman, P.W.; Wheeler-Kingshott, C.; Bacon, M.; Schwab, J.M.; Bosma, R.; Brooks, J.; Cadotte, D.; Carlstedt, T.; Ciccarelli, O.; Cohen-Adad, J.; Curt, A.; Evangelou, N.; Fehlings, M.G.; Filippi, M.; Kelley, B.J.; Kollias, S.; Mackay, A.; Porro, C.A.; Smith, S.; Strittmatter, S.M.; Summers, P.; Tracey, I.
2015-01-01
A first-ever spinal cord imaging meeting was sponsored by the International Spinal Research Trust and the Wings for Life Foundation with the aim of identifying the current state-of-the-art of spinal cord imaging, the current greatest challenges, and greatest needs for future development. This meeting was attended by a small group of invited experts spanning all aspects of spinal cord imaging from basic research to clinical practice. The greatest current challenges for spinal cord imaging were identified as arising from the imaging environment itself; difficult imaging environment created by the bone surrounding the spinal canal, physiological motion of the cord and adjacent tissues, and small cross-sectional dimensions of the spinal cord, exacerbated by metallic implants often present in injured patients. Challenges were also identified as a result of a lack of “critical mass” of researchers taking on the development of spinal cord imaging, affecting both the rate of progress in the field, and the demand for equipment and software to manufacturers to produce the necessary tools. Here we define the current state-of-the-art of spinal cord imaging, discuss the underlying theory and challenges, and present the evidence for the current and potential power of these methods. In two review papers (part I and part II), we propose that the challenges can be overcome with advances in methods, improving availability and effectiveness of methods, and linking existing researchers to create the necessary scientific and clinical network to advance the rate of progress and impact of the research. PMID:23685159
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Brout, Jennifer J.; Edelstein, Miren; Erfanian, Mercede; Mannino, Michael; Miller, Lucy J.; Rouw, Romke; Kumar, Sukhbinder; Rosenthal, M. Zachary
2018-01-01
Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. The aims of this review are to (a) characterize the current state of the field of research on misophonia, (b) highlight what can be inferred from the small research literature to inform treatment of individuals with misophonia, and (c) outline an agenda for research on this topic. We extend previous reviews on this topic by critically reviewing the research investigating mechanisms of misophonia and differences between misophonia and other conditions. In addition, we integrate this small but growing literature with basic and applied research from other literatures in a cross-disciplinary manner. PMID:29467604
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Brout, Jennifer J; Edelstein, Miren; Erfanian, Mercede; Mannino, Michael; Miller, Lucy J; Rouw, Romke; Kumar, Sukhbinder; Rosenthal, M Zachary
2018-01-01
Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. The aims of this review are to (a) characterize the current state of the field of research on misophonia, (b) highlight what can be inferred from the small research literature to inform treatment of individuals with misophonia, and (c) outline an agenda for research on this topic. We extend previous reviews on this topic by critically reviewing the research investigating mechanisms of misophonia and differences between misophonia and other conditions. In addition, we integrate this small but growing literature with basic and applied research from other literatures in a cross-disciplinary manner.
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What is Basic Research? Insights from Historical Semantics.
Schauz, Désirée
2014-01-01
For some years now, the concept of basic research has been under attack. Yet although the significance of the concept is in doubt, basic research continues to be used as an analytical category in science studies. But what exactly is basic research? What is the difference between basic and applied research? This article seeks to answer these questions by applying historical semantics. I argue that the concept of basic research did not arise out of the tradition of pure science. On the contrary, this new concept emerged in the late 19th and early 20th centuries, a time when scientists were being confronted with rising expectations regarding the societal utility of science. Scientists used the concept in order to try to bridge the gap between the promise of utility and the uncertainty of scientific endeavour. Only after 1945, when United States science policy shaped the notion of basic research, did the concept revert to the older ideals of pure science. This revival of the purity discourse was caused by the specific historical situation in the US at that time: the need to reform federal research policy after the Second World War, the new dimension of ethical dilemmas in science and technology during the atomic era, and the tense political climate during the Cold War.
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Galinsky, Vitaly L; Martinez, Antigona; Paulus, Martin P; Frank, Lawrence R
2018-04-13
In this letter, we present a new method for integration of sensor-based multifrequency bands of electroencephalography and magnetoencephalography data sets into a voxel-based structural-temporal magnetic resonance imaging analysis by utilizing the general joint estimation using entropy regularization (JESTER) framework. This allows enhancement of the spatial-temporal localization of brain function and the ability to relate it to morphological features and structural connectivity. This method has broad implications for both basic neuroscience research and clinical neuroscience focused on identifying disease-relevant biomarkers by enhancing the spatial-temporal resolution of the estimates derived from current neuroimaging modalities, thereby providing a better picture of the normal human brain in basic neuroimaging experiments and variations associated with disease states.
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Kashani, Alireza G; Olsen, Michael J; Parrish, Christopher E; Wilson, Nicholas
2015-11-06
In addition to precise 3D coordinates, most light detection and ranging (LIDAR) systems also record "intensity", loosely defined as the strength of the backscattered echo for each measured point. To date, LIDAR intensity data have proven beneficial in a wide range of applications because they are related to surface parameters, such as reflectance. While numerous procedures have been introduced in the scientific literature, and even commercial software, to enhance the utility of intensity data through a variety of "normalization", "correction", or "calibration" techniques, the current situation is complicated by a lack of standardization, as well as confusing, inconsistent use of terminology. In this paper, we first provide an overview of basic principles of LIDAR intensity measurements and applications utilizing intensity information from terrestrial, airborne topographic, and airborne bathymetric LIDAR. Next, we review effective parameters on intensity measurements, basic theory, and current intensity processing methods. We define terminology adopted from the most commonly-used conventions based on a review of current literature. Finally, we identify topics in need of further research. Ultimately, the presented information helps lay the foundation for future standards and specifications for LIDAR radiometric calibration.