Predictive Model Development for Aviation Black Carbon Mass Emissions from Alternative and Conventional Fuels at Ground and Cruise.

PubMed

Abrahamson, Joseph P; Zelina, Joseph; Andac, M Gurhan; Vander Wal, Randy L

2016-11-01

The first order approximation (FOA3) currently employed to estimate BC mass emissions underpredicts BC emissions due to inaccuracies in measuring low smoke numbers (SNs) produced by modern high bypass ratio engines. The recently developed Formation and Oxidation (FOX) method removes the need for and hence uncertainty associated with (SNs), instead relying upon engine conditions in order to predict BC mass. Using the true engine operating conditions from proprietary engine cycle data an improved FOX (ImFOX) predictive relation is developed. Still, the current methods are not optimized to estimate cruise emissions nor account for the use of alternative jet fuels with reduced aromatic content. Here improved correlations are developed to predict engine conditions and BC mass emissions at ground and cruise altitude. This new ImFOX is paired with a newly developed hydrogen relation to predict emissions from alternative fuels and fuel blends. The ImFOX is designed for rich-quench-lean style combustor technologies employed predominately in the current aviation fleet.

The Historical Context, Current Development, and Future Challenges of Distance Education in Indonesia

ERIC Educational Resources Information Center

Zuhairi, Aminudin; Wahyono, Effendi; Suratinah, Sharon

2006-01-01

This article addresses the historical context, current development, and future challenges of distance education in Indonesia. Conditions related to the geography, demography, socio-economic and cultural situations, as well as the availability of technology have encouraged the use of distance education as a valid choice in providing access to…

Current and future perspectives on the development, evaluation and application of in silico approaches for predicting toxicity

EPA Science Inventory

Safety-related problems continue to be one of the major reasons of attrition in drug development. Non-testing approaches to predict toxicity could form part of the solution. This review provides a perspective of current status of non-testing approaches available for the predictio...

Current and anticipated uses of thermal-hydraulic codes in NFI

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsuda, K.; Takayasu, M.

1997-07-01

This paper presents the thermal-hydraulic codes currently used in NFI for the LWR fuel development and licensing application including transient and design basis accident analyses of LWR plants. The current status of the codes are described in the context of code capability, modeling feature, and experience of code application related to the fuel development and licensing. Finally, the anticipated use of the future thermal-hydraulic code in NFI is briefly given.

Tests of the relative roles of calcium channels and calcium pumps in controlling gravity-directed development in single spore cells of the fern Ceratopteris richardii

NASA Astrophysics Data System (ADS)

Roux, Stanley; Porterfield, D. Marshall; Haque, Aeraj Ul; Bushart, Thomas

The vector of gravity sets the direction of polarized development of single spore cells of the fern Ceratopteris richardii after light initiates their germination. Gravity also sets the direction of a trans-cell calcium current, which enters the cell along its bottom and exits it from its top. The direction of this current predicts the subsequent direction of spore development, and blocking this current with calcium channel blockers randomizes the direction of subsequent development. Recently the laboratory of D. Marshall Porterfield (Purdue University) developed a microchip device that can measure the direction and magnitude of the trans-spore calcium current in real time. Our laboratory in collaboration with Porterfield's recently found that this current inverts rapidly when the cells are turned upside down and that the magnitude of the current rises and falls with the magnitude of the g-force when these cells are tested in parabolic flight on the DC-9 aircraft. We assume that the gravity-directed entry of calcium into these cells is through calcium channels and its exit is through calcium pumps. Here we report our studies of a calcium pump that is highly expressed in the spores during the period when gravity is setting the direction of the calcium current, and we describe pharmacological tests of the relative importance of calcium pumps in maintaining the calcium current and in controlling the direction of subsequent spore development. We found that inhibitors that block the activity of calcium pumps also greatly depress the trans-cell current, but, surprisingly, have little effect on the ability of gravity to set the direction of spore development. These results, in combination with earlier findings, indicate that the gravity-directed opening of calcium channels along the bottom of spore cells plays a more important role in directing subsequent spore development than the activity of calcium pumps, despite the importance of these pumps in maintaining the trans-cell calcium current. Supported by NASA grants NAG2-1586 and NAG10-295 to S. J. R.

The development of the genital peritoneum in domestic mammals. An analysis of the literature and nomenclature.

PubMed

Martin, E

1995-12-01

This review presents and discusses the reasons for the currently employed anatomical terminology relating to the genital peritoneum of various domestic species, based upon its prenatal development. When reviewing the development of genital organs, attention must be paid to changes in the related peritoneum in order to define currently used terminology more clearly. The relevance of some terms such as Caudal genital ligament, Plica gubernaculi, Plica iguinalis and genital fold is considered. A system of serosal folds, the Plica gonadoinguinalis or genitoinguinalis, seems to be a useful term to be added to the Nomina Embryologica Veterinaria.

Software development tools: A bibliography, appendix C.

NASA Technical Reports Server (NTRS)

Riddle, W. E.

1980-01-01

A bibliography containing approximately 200 citations on tools which help software developers perform some development task (such as text manipulation, testing, etc.), and which would not necessarily be found as part of a computing facility is given. The bibliography comes from a relatively random sampling of the literature and is not complete. But it is indicative of the nature and range of tools currently being prepared or currently available.

Maternal Accuracy and Behavior in Anticipating Children's Responses to Novelty: Relations to Fearful Temperament and Implications for Anxiety Development

ERIC Educational Resources Information Center

Kiel, Elizabeth J.; Buss, Kristin A.

2010-01-01

Previous research has suggested that mothers' behaviors may serve as a mechanism in the development from toddler fearful temperament to childhood anxiety. The current study examined the maternal characteristic of accuracy in predicting toddlers' distress reactions to novelty in relation to temperament, parenting, and anxiety development.…

The Relation of Economic Status to Subjective Well-Being in Developing Countries: A Meta-Analysis

ERIC Educational Resources Information Center

Howell, Ryan T.; Howell, Colleen J.

2008-01-01

The current research synthesis integrates the findings of 111 independent samples from 54 economically developing countries that examined the relation between economic status and subjective well-being (SWB). The average economic status-SWB effect size was strongest among low-income developing economies (r = 0.28) and for samples that were least…

Investigating the development of double-peak subauroral ion drift (DSAID)

NASA Astrophysics Data System (ADS)

Horvath, Ildiko; Lovell, Brian C.

2017-04-01

This study focuses on the newly described ionospheric feature, called double-peak subauroral ion drift (DSAID), which is a subclass of the well-known single-peak SAID. Double-layer Region 2 (R2) field aligned currents (FACs) could be the main driver of DSAID. Our aim is to gain new insights into the development of DSAID during its two-stage progression. Observational results are provided by five scenarios, each demonstrating a certain progression sequence of DSAID. Results show that SAID/DSAID occurred during flux transfer events and was accompanied by flow channels (FCs) associated with dayside magnetopause (FC-2) and nightside magnetotail (FC-3) reconnections, with westward electrojet (eastward FC), and with auroral streamers (FC-4). In the premidnight magnetic local time (MLT) sector of stage 2, DSAID development was due to the short-circuiting of the reconnection-injected plasma jets during substorms or pseudobreakups. Thus, the related ring current pressure buildup enhanced the downward R2 FACs leading to double/multiple circuits forming double-layer R2 FACs. During the midnight MLT hours of stage 2, DSAID development was closely related to the westward traveling surge (WTS)/substorm current wedge (SCW). WTS/SCW-related strong upward R1 FACs closed with meriodional currents producing eastward and downward (i.e., downward R2 FAC-style) return currents enhancing the downward R2 FACs and thus leading to double/multiple circuits forming double-layer R2 FACs. Auroral streamers/FC-4 represent a substorm substructure and their occurrence with DSAID after stage 2 demonstrates that this substructure occasionally includes DSAID. Our results demonstrate also that the short-circuited system underlying SAID/DSAID acted sometimes as a current generator and sometimes as a voltage generator.

Incentive-Related Modulation of Cognitive Control in Healthy, Anxious, and Depressed Adolescents: Development and Psychopathology Related Differences

ERIC Educational Resources Information Center

Hardin, Michael G.; Schroth, Elizabeth; Pine, Daniel S.; Ernst, Monique

2007-01-01

Background: Developmental changes in cognitive and affective processes contribute to adolescent risk-taking behavior, emotional intensification, and psychopathology. The current study examined adolescent development of cognitive control processes and their modulation by incentive, in health and psychopathology. Predictions include 1) better…

The Motivation to Serve Others: Exploring Relations to Career Development

ERIC Educational Resources Information Center

Duffy, Ryan D.; Raque-Bogdan, Trisha L.

2010-01-01

The current study explored the relation between service motivation, or the desire to serve others through one's future career, and vocational outcomes across two studies. In the first study, using a sample of 225 undergraduate students, an instrument was developed to measure service motivation that demonstrated convergent and discriminant…

Self-Esteem and Self-in-Relation Identity among Mexican American Adolescents.

ERIC Educational Resources Information Center

Perez, Gabriela L.; Russell, Todd T.

Traditional theories of development view separation and individuation as primary tasks of adolescents; the self-in-relation framework, however, argues that the autonomous and separate self-paradigm does not describe female development. Current research suggests that self-esteem arises from subscribing to separate self-definitions for males and…

An Algorithm for Interactive Modeling of Space-Transportation Engine Simulations: A Constraint Satisfaction Approach

NASA Technical Reports Server (NTRS)

Mitra, Debasis; Thomas, Ajai; Hemminger, Joseph; Sakowski, Barbara

2001-01-01

In this research we have developed an algorithm for the purpose of constraint processing by utilizing relational algebraic operators. Van Beek and others have investigated in the past this type of constraint processing from within a relational algebraic framework, producing some unique results. Apart from providing new theoretical angles, this approach also gives the opportunity to use the existing efficient implementations of relational database management systems as the underlying data structures for any relevant algorithm. Our algorithm here enhances that framework. The algorithm is quite general in its current form. Weak heuristics (like forward checking) developed within the Constraint-satisfaction problem (CSP) area could be also plugged easily within this algorithm for further enhancements of efficiency. The algorithm as developed here is targeted toward a component-oriented modeling problem that we are currently working on, namely, the problem of interactive modeling for batch-simulation of engineering systems (IMBSES). However, it could be adopted for many other CSP problems as well. The research addresses the algorithm and many aspects of the problem IMBSES that we are currently handling.

Marine current energy conversion: the dawn of a new era in electricity production.

PubMed

Bahaj, AbuBakr S

2013-02-28

Marine currents can carry large amounts of energy, largely driven by the tides, which are a consequence of the gravitational effects of the planetary motion of the Earth, the Moon and the Sun. Augmented flow velocities can be found where the underwater topography (bathymetry) in straits between islands and the mainland or in shallows around headlands plays a major role in enhancing the flow velocities, resulting in appreciable kinetic energy. At some of these sites where practical flows are more than 1 m s(-1), marine current energy conversion is considered to be economically viable. This study describes the salient issues related to the exploitation of marine currents for electricity production, resource assessment, the conversion technologies and the status of leading projects in the field. This study also summarizes important issues related to site development and some of the approaches currently being undertaken to inform device and array development. This study concludes that, given the highlighted commitments to establish favourable regulatory and incentive regimes as well as the aspiration for energy independence and combating climate change, the progress to multi-megawatt arrays will be much faster than that achieved for wind energy development.

24 CFR 1000.317 - Who is the recipient for funds for current assisted stock which is owned by state-created...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Who is the recipient for funds for current assisted stock which is owned by state-created Regional Native Housing Authorities in Alaska? 1000.317 Section 1000.317 Housing and Urban Development Regulations Relating to Housing and Urban...

20 Years after "The Ontogeny of Human Memory: A Cognitive Neuroscience Perspective," Where Are We?

ERIC Educational Resources Information Center

Jabès, Adeline; Nelson, Charles A.

2015-01-01

In 1995, Nelson published a paper describing a model of memory development during the first years of life. The current article seeks to provide an update on the original work published 20 years ago. Specifically, we review our current knowledge on the relation between the emergence of explicit memory functions throughout development and the…

Integrating 3D Visualization and GIS in Planning Education

ERIC Educational Resources Information Center

Yin, Li

2010-01-01

Most GIS-related planning practices and education are currently limited to two-dimensional mapping and analysis although 3D GIS is a powerful tool to study the complex urban environment in its full spatial extent. This paper reviews current GIS and 3D visualization uses and development in planning practice and education. Current literature…

Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons

PubMed Central

Guan, Dongxu; Horton, Leslie R.; Armstrong, William E.

2011-01-01

Potassium channels regulate numerous aspects of neuronal excitability, and several voltage-gated K+ channel subunits have been identified in pyramidal neurons of rat neocortex. Previous studies have either considered the development of outward current as a whole or divided currents into transient, A-type and persistent, delayed rectifier components but did not differentiate between current components defined by α-subunit type. To facilitate comparisons of studies reporting K+ currents from animals of different ages and to understand the functional roles of specific current components, we characterized the postnatal development of identified Kv channel-mediated currents in pyramidal neurons from layers II/III from rat somatosensory cortex. Both the persistent/slowly inactivating and transient components of the total K+ current increased in density with postnatal age. We used specific pharmacological agents to test the relative contributions of putative Kv1- and Kv2-mediated currents (100 nM α-dendrotoxin and 600 nM stromatoxin, respectively). A combination of voltage protocol, pharmacology, and curve fitting was used to isolate the rapidly inactivating A-type current. We found that the density of all identified current components increased with postnatal age, approaching a plateau at 3–5 wk. We found no significant changes in the relative proportions or kinetics of any component between postnatal weeks 1 and 5, except that the activation time constant for A-type current was longer at 1 wk. The putative Kv2-mediated component was the largest at all ages. Immunocytochemistry indicated that protein expression for Kv4.2, Kv4.3, Kv1.4, and Kv2.1 increased between 1 wk and 4–5 wk of age. PMID:21451062

Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.

PubMed

Guan, Dongxu; Horton, Leslie R; Armstrong, William E; Foehring, Robert C

2011-06-01

Potassium channels regulate numerous aspects of neuronal excitability, and several voltage-gated K(+) channel subunits have been identified in pyramidal neurons of rat neocortex. Previous studies have either considered the development of outward current as a whole or divided currents into transient, A-type and persistent, delayed rectifier components but did not differentiate between current components defined by α-subunit type. To facilitate comparisons of studies reporting K(+) currents from animals of different ages and to understand the functional roles of specific current components, we characterized the postnatal development of identified Kv channel-mediated currents in pyramidal neurons from layers II/III from rat somatosensory cortex. Both the persistent/slowly inactivating and transient components of the total K(+) current increased in density with postnatal age. We used specific pharmacological agents to test the relative contributions of putative Kv1- and Kv2-mediated currents (100 nM α-dendrotoxin and 600 nM stromatoxin, respectively). A combination of voltage protocol, pharmacology, and curve fitting was used to isolate the rapidly inactivating A-type current. We found that the density of all identified current components increased with postnatal age, approaching a plateau at 3-5 wk. We found no significant changes in the relative proportions or kinetics of any component between postnatal weeks 1 and 5, except that the activation time constant for A-type current was longer at 1 wk. The putative Kv2-mediated component was the largest at all ages. Immunocytochemistry indicated that protein expression for Kv4.2, Kv4.3, Kv1.4, and Kv2.1 increased between 1 wk and 4-5 wk of age.

Trends in Mobile Application Development

NASA Astrophysics Data System (ADS)

Holzer, Adrian; Ondrus, Jan

Major software companies, such as Apple and Google, are disturbing the relatively safe and established actors of the mobile application business. These newcomers have caused significant structural changes by imposing and enforcing their own rules for the future of mobile application development. The implications of these changes do not only concern the mobile network operators and mobile phone manufacturers. This changed environment also brings additional opportunities and constraints for current mobile application developers. Therefore, developers need to assess what their options are and how they can take advantages of these current trends. In this paper, we take a developer’s perspective in order to explore how the structural changes will influence the mobile application development markets. Moreover, we discuss what aspects developers need to take into account in order to position themselves within the current trends.

Integration of simulation in postgraduate studies in Saudi Arabia: The current practice in anesthesia training program

PubMed Central

Arab, Abeer; Alatassi, Abdulaleem; Alattas, Elias; Alzoraigi, Usamah; AlZaher, Zaki; Ahmad, Abdulaziz; Albabtain, Hesham; Boker, Abdulaziz

2017-01-01

The educational programs in the Saudi Commission for Health Specialties are developing rapidly in the fields of technical development. Such development is witnessed, particularly in the scientific areas related to what is commonly known as evidence-based medicine. This review highlights the critical need and importance of integrating simulation into anesthesia training and assessment. Furthermore, it describes the current utilization of simulation in anesthesia and critical care assessment process. PMID:28442961

Teaching Ethics across the Public Relations Curriculum.

ERIC Educational Resources Information Center

Hutchison, Liese L.

2002-01-01

Suggests ways of incorporating ethics across the undergraduate public relations curriculum. Reviews current coverage of ethics in public relations principles, writing, cases, and textbooks. Suggests other methods that teachers can use to incorporate ethical pedagogical tools in all public relations courses in an effort to develop students' ethical…

GIRLSS: A Study of the Effectiveness of a Multi-Modal Intervention to Reduce Relational Aggression

ERIC Educational Resources Information Center

Splett, Joni Williams

2012-01-01

Relational aggression has quickly become a serious issue in schools. In response, school professionals have sought and developed interventions despite a dearth of empirical examination and support. The current study bolsters this area by examining the initial efficacy of GIRLSS, an intervention developed over multiple iterations incorporating the…

From Survivor to Thriver: A Pilot Study of an Online Program for Rape Victims

PubMed Central

Littleton, Heather; Buck, Katherine; Rosman, Lindsey; Grills-Taquechel, Amie

2013-01-01

Approximately 15% to 20% of women have been victims of rape and close to a third report current rape-related PTSD or clinically significant depression or anxiety. Unfortunately, very few distressed rape victims seek formal help. This suggests a need to develop alternative ways to assist the many distressed victims of sexual violence. Online treatment programs represent a potentially important alternative strategy for reaching such individuals. The current paper describes a pilot evaluation of an online, therapist-facilitated, self-paced cognitive behavioral program for rape victims. Five college women with current rape-related PTSD were recruited to complete the From Survivor to Thriver (S to T) program in a lab setting over the course of 7 weeks. After completing the program, 4 participants reported clinically significant reductions in PTSD symptoms and no longer met criteria for PTSD. All participants reported clinically significant reductions in vulnerability fears and 4 reported significant reductions in negative trauma-related cognitions. Implications of the results for further development of the S to T program and how clinicians could utilize this program in treating rape-related PTSD are discussed. PMID:24009410

Investigation and Modeling of Cranberry Weather Stress.

NASA Astrophysics Data System (ADS)

Croft, Paul Joseph

Cranberry bog weather conditions and weather-related stress were investigated for development of crop yield prediction models and models to predict daily weather conditions in the bog. Field investigations and data gathering were completed at the Rutgers University Blueberry/Cranberry Research Center experimental bogs in Chatsworth, New Jersey. Study indicated that although cranberries generally exhibit little or no stomatal response to changing atmospheric conditions, the evaluation of weather-related stress could be accomplished via use of micrometeorological data. Definition of weather -related stress was made by establishing critical thresholds of the frequencies of occurrence, and magnitudes of, temperature and precipitation in the bog based on values determined by a review of the literature and a grower questionnaire. Stress frequencies were correlated with cranberry yield to develop predictive models based on the previous season's yield, prior season data, prior and current season data, current season data; and prior and current season data through July 31 of the current season. The predictive ability of the prior season models was best and could be used in crop planning and production. Further examination of bog micrometeorological data permitted the isolation of those weather conditions conducive to cranberry scald and allowed for the institution of a pilot scald advisory program during the 1991 season. The micrometeorological data from the bog was also used to develop models to predict daily canopy temperature and precipitation, based on upper air data, for grower use. Models were developed for each month for maximum and minimum temperatures and for precipitation and generally performed well. The modeling of bog weather conditions is an important first step toward daily prediction of cranberry weather-related stress.

Acceptance procedures for dense-graded mixes

DOT National Transportation Integrated Search

2001-03-01

Recent literature related to acceptance procedures for dense-graded mixtures is summarized. Current state of practice and development of acceptance procedures are reviewed. Many agencies are reducing the number of process control-related parameters i...

NASA Glenn Research Center Electrochemistry Branch Overview

NASA Technical Reports Server (NTRS)

Manzo, Michelle A.; Hoberecht, Mark; Reid, Concha

2010-01-01

This presentation covers an overview of NASA Glenn's history and heritage in the development of electrochemical systems for aerospace applications. Current programs related to batteries and fuel cells are addressed. Specific areas of focus are Li-ion batteries and Polymer Electrolyte Membrane Fuel cells systems and their development for future Exploration missions. The presentation covers details of current component development efforts for high energy and ultra high energy Li-ion batteries and non-flow-through fuel cell stack and balance of plant development. Electrochemistry Branch capabilities and facilities are also addressed.

Hostile Intent Attributions and Relational Aggression: The Moderating Roles of Emotional Sensitivity, Gender, and Victimization

ERIC Educational Resources Information Center

Mathieson, Lindsay C.; Murray-Close, Dianna; Crick, Nicki R.; Woods, Kathleen E.; Zimmer-Gembeck, Melanie; Geiger, Tasha C.; Morales, Julie R.

2011-01-01

The current study adopts a relational vulnerability model to examine the association between hostile attribution bias and relational aggression. Specifically, the relational vulnerability model implicates the interactive effects of a number of relational risk factors in the development of relational aggression. A sample of 635 3rd, 4th, and 5th…

Characterization of AC current sensor based on giant magnetoresistance and coil for power meter design

NASA Astrophysics Data System (ADS)

Dhani, H. S.; Aminudin, A.; Waslaluddin

2018-05-01

Electric current is the basic variable of measurement in instrumentation system. One of the current measurements had been developed was based on magnetic sensor. Giant Magnetoresistance (GMR) produces an output voltage when it detects the magnetic field from electric current flow. The purpose of this study was to characterize the response of GMR when variation number of coil was given. The characterization was the GMR voltage response to the AC current values from 0.01 A to 5.00 A. The linearity of the relation was reaching saturation point when the magnetic field measured higher than 10.5 Oe at room temperature. As the number of coil increased, the earlier saturation occurred. To see the sensitivity of the sensor response, the data graph was cut off at 1.56 A AC. From this research, we got single coil was ideal to measure electric current higher than 1.56 A AC, as the relation of GMR voltage to the current tended to maintain its linearity. For measurement of 1.56 A AC and less, coil number addition would increase the sensitivity of sensor response. This research hopefully will be benefit for further development using an electric current measurement based on GMR magnetic sensor for power meter design.

II. Model building: an electrical theory of control of growth and development in animals, prompted by studies of exogenous magnetic field effects (paper I), and evidence of DNA current conduction, in vitro.

PubMed

Elson, Edward

2009-01-01

A theory of control of cellular proliferation and differentiation in the early development of metazoan systems, postulating a system of electrical controls "parallel" to the processes of molecular biochemistry, is presented. It is argued that the processes of molecular biochemistry alone cannot explain how a developing organism defies a stochastic universe. The demonstration of current flow (charge transfer) along the long axis of DNA through the base-pairs (the "pi-way) in vitro raises the question of whether nature may employ such current flows for biological purposes. Such currents might be too small to be accessible to direct measurement in vivo but conduction has been measured in vitro, and the methods might well be extended to living systems. This has not been done because there is no reasonable model which could stimulate experimentation. We suggest several related, but detachable or independent, models for the biological utility of charge transfer, whose scope admittedly outruns current concepts of thinking about organization, growth, and development in eukaryotic, metazoan systems. The ideas are related to explanations proposed to explain the effects demonstrated on tumors and normal tissues described in Article I (this issue). Microscopic and mesoscopic potential fields and currents are well known at sub-cellular, cellular, and organ systems levels. Not only are such phenomena associated with internal cellular membranes in bioenergetics and information flow, but remarkable long-range fields over tissue interfaces and organs appear to play a role in embryonic development (Nuccitelli, 1992 ). The origin of the fields remains unclear and is the subject of active investigation. We are proposing that similar processes could play a vital role at a "sub-microscopic level," at the level of the chromosomes themselves, and could play a role in organizing and directing fundamental processes of growth and development, in parallel with the more discernible fields and currents described.

The 300 mA SRF ERL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ben-Zvi, Ilan

Energy Recovery Linacs (ERL) are important for a variety of applications, from high-power Free-Electron Lasers (FEL) to polarized-electron polarized-proton colliders. The ERL current is arguably the most important characteristic of ERLs for such applications. With that in mind, the Collider-Accelerator Department at Brookhaven National Laboratory embarked on the development of a 300 mA ERL to serve as an R and D test-bed for high-current ERL technologies. These include high-current, extremely well damped superconducting accelerating cavities, high-current superconducting laser-photocathode electron guns and high quantum-efficiency photocathodes. In this presentation I will cover these ERL related developments.

Substance Abuse and Counseling: An Epilogue.

ERIC Educational Resources Information Center

Sales, Amos

This chapter discusses current issues and future perspectives in relation to substance abuse counseling. Current issues include: abstinence versus controlled use; coercive versus voluntary treatment; and career development and counseling with clients with substance abuse problems. Future perspectives include: the impact of managed care; the…

The Development of Professional Learning Community in Primary Schools

ERIC Educational Resources Information Center

Sompong, Samoot; Erawan, Prawit; Dharm-tad-sa-na-non, Sudharm

2015-01-01

The objectives of this research are: (1) To study the current situation and need for developing professional learning community in primary schools; (2) To develop the model for developing professional learning community, and (3) To study the findings of development for professional learning community based on developed model related to knowledge,…

Acceptance procedures for dense-graded mixes : literature review.

DOT National Transportation Integrated Search

2001-03-01

Recent literature related to acceptance procedures for dense-graded mixtures is summarized. Current state of practice and development of acceptance procedures are reviewed. Many agencies are reducing the number of process control-related parameters i...

Moving toward Multiliteracies in Foreign Language Teaching: Past and Present Perspectives … and Beyond

ERIC Educational Resources Information Center

Warner, Chantelle; Dupuy, Beatrice

2018-01-01

In recent years, literacy has emerged as a key critical term in foreign language (FL) teaching and learning. This essay reflects on the history of literacy and on current developments, in particular those related to the development of multiliteracies paradigms. The article concludes with a discussion of emergent topics related to literacy and…

The Development and Evaluation of a Measure Assessing School Nurses' Perceived Barriers to Addressing Pediatric Obesity

ERIC Educational Resources Information Center

Wu, Yelena P.; Steele, Ric G.

2011-01-01

School nurses represent an important resource for addressing pediatric obesity and weight-related health. However, school nurses perceive numerous barriers that prevent them from addressing the weight-related health of students. The current study developed and tested a new, comprehensive measure of nurses' perceptions of 10 types of barriers to…

Enhanced Development of Auditory Change Detection in Musically Trained School-Aged Children: A Longitudinal Event-Related Potential Study

ERIC Educational Resources Information Center

Putkinen, Vesa; Tervaniemi, Mari; Saarikivi, Katri; Ojala, Pauliina; Huotilainen, Minna

2014-01-01

Adult musicians show superior auditory discrimination skills when compared to non-musicians. The enhanced auditory skills of musicians are reflected in the augmented amplitudes of their auditory event-related potential (ERP) responses. In the current study, we investigated longitudinally the development of auditory discrimination skills in…

Ocean dynamics studies. [of current-wave interactions

NASA Technical Reports Server (NTRS)

1974-01-01

Both the theoretical and experimental investigations into current-wave interactions are discussed. The following three problems were studied: (1) the dispersive relation of a random gravity-capillary wave field; (2) the changes of the statistical properties of surface waves under the influence of currents; and (3) the interaction of capillary-gravity with the nonuniform currents. Wave current interaction was measured and the feasibility of using such measurements for remote sensing of surface currents was considered. A laser probe was developed to measure the surface statistics, and the possibility of using current-wave interaction as a means of current measurement was demonstrated.

Limitations of the Conventional Phase Advance Method for Constant Power Operation of the Brushless DC Motor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawler, J.S.

2001-10-29

The brushless dc motor (BDCM) has high-power density and efficiency relative to other motor types. These properties make the BDCM well suited for applications in electric vehicles provided a method can be developed for driving the motor over the 4 to 6:1 constant power speed range (CPSR) required by such applications. The present state of the art for constant power operation of the BDCM is conventional phase advance (CPA) [1]. In this paper, we identify key limitations of CPA. It is shown that the CPA has effective control over the developed power but that the current magnitude is relatively insensitivemore » to power output and is inversely proportional to motor inductance. If the motor inductance is low, then the rms current at rated power and high speed may be several times larger than the current rating. The inductance required to maintain rms current within rating is derived analytically and is found to be large relative to that of BDCM designs using high-strength rare earth magnets. Th us, the CPA requires a BDCM with a large equivalent inductance.« less

Current status of rotavirus vaccines.

PubMed

Wang, Ching-Min; Chen, Shou-Chien; Chen, Kow-Tong

2015-11-01

Rotaviruses remain the major cause of childhood diarrheal disease worldwide and of diarrheal deaths of infants and children in developing countries. The huge burden of childhood rotavirus-related diarrhea in the world continues to drive the remarkable pace of vaccine development. Research articles were searched using terms "rotavirus" and "rotavirus vaccine" in MEDLINE and PubMed. Articles not published in the English language, articles without abstracts, and opinion articles were excluded from the review. After preliminary screening, all articles were reviewed and synthesized to provide an overview of current vaccines and vaccination programs. In this review of the global rotavirus vaccines and vaccination programs, the principles of rotavirus vaccine development and the efficacy of the currently licensed vaccines from both developed and developing countries were summarized. Rotavirus is a common cause of diarrhea in children in both developed and developing countries. Rotavirus vaccination is a cost-effective measure to prevent rotavirus diarrhea.

A Few Examples of Spacecraft Anomalies Attributed to Transient Voltages and Currents Issues

NASA Technical Reports Server (NTRS)

Perez, Ray

2006-01-01

It is easy to address voltage and current transient related issues when the hardware in question or similar type of hardware is always available to you and when such issues are deterministic in nature. Unexpected or unforeseen transient related problems are not always a challenge but become a severe concern when a unique piece of the hardware, which developed the problem, is in space; as it is with all satellites. This paper addresses in a qualitative manner, a few examples of voltage and current events of transient origin which disabled space hardware.

Development of surface friction guidelines for LADOTD : tech summary.

DOT National Transportation Integrated Search

2012-04-01

The current Louisiana Department of Transportation and Development (LADOTD) surface friction guidelines deal with the polished : stone values (PSV) of coarse aggregates (which is a relative British Pendulum skid-resistance number measured on polished...

Marshall Space Flight Center CFD overview

NASA Technical Reports Server (NTRS)

Schutzenhofer, Luke A.

1989-01-01

Computational Fluid Dynamics (CFD) activities at Marshall Space Flight Center (MSFC) have been focused on hardware specific and research applications with strong emphasis upon benchmark validation. The purpose here is to provide insight into the MSFC CFD related goals, objectives, current hardware related CFD activities, propulsion CFD research efforts and validation program, future near-term CFD hardware related programs, and CFD expectations. The current hardware programs where CFD has been successfully applied are the Space Shuttle Main Engines (SSME), Alternate Turbopump Development (ATD), and Aeroassist Flight Experiment (AFE). For the future near-term CFD hardware related activities, plans are being developed that address the implementation of CFD into the early design stages of the Space Transportation Main Engine (STME), Space Transportation Booster Engine (STBE), and the Environmental Control and Life Support System (ECLSS) for the Space Station. Finally, CFD expectations in the design environment will be delineated.

FINANCIAL ANALYSIS OF CURRENT OPERATIONS OF COLLEGES AND UNIVERSITIES.

ERIC Educational Resources Information Center

SWANSON, JOHN E.; AND OTHERS

TECHNIQUES FOR DEVELOPING FINANCIAL AND RELATED COST-EFFECTIVENESS DATA FOR PUBLIC AND PRIVATELY SUPPORTED AMERICAN COLLEGES AND UNIVERSITIES WERE STUDIED TO FORMULATE PRINCIPLES, PROCEDURES, AND STANDARDS FOR THE ACCUMULATION AND ANALYSES OF CURRENT OPERATING COSTS. AFTER SEPARATE ANALYSES OF INSTITUTIONAL PROCEDURES AND REPORTS, ANALYTIC UNITS…

Regulatory Developments in Cable Television.

ERIC Educational Resources Information Center

Federal Communications Commission, Washington, DC.

This report summarizes major rule making actions since 1972, current rules and regulations, and guidelines for citizen participation in FCC (Federal Communications Commission) processes related to cable television regulation. A large portion of the report pertains to current rules and regulations in the areas of certificate of compliance,…

Critical Care Nurses' Reasons for Poor Attendance at a Continuous Professional Development Program.

PubMed

Viljoen, Myra; Coetzee, Isabel; Heyns, Tanya

2016-12-01

Society demands competent and safe health care, which obligates professionals to deliver quality patient care using current knowledge and skills. Participation in continuous professional development programs is a way to ensure quality nursing care. Despite the importance of continuous professional development, however, critical care nurse practitioners' attendance rates at these programs is low. To explore critical care nurses' reasons for their unsatisfactory attendance at a continuous professional development program. A nominal group technique was used as a consensus method to involve the critical care nurses and provide them the opportunity to reflect on their experiences and challenges related to the current continuous professional development program for the critical care units. Participants were 14 critical care nurses from 3 critical care units in 1 private hospital. The consensus was that the central theme relating to the unsatisfactory attendance at the continuous professional development program was attitude. In order of importance, the 4 contributing priorities influencing attitude were communication, continuous professional development, time constraints, and financial implications. Attitude relating to attending a continuous professional development program can be changed if critical care nurses are aware of the program's importance and are involved in the planning and implementation of a program that focuses on the nurses' individual learning needs. ©2016 American Association of Critical-Care Nurses.

The Interpersonal Theory of Suicide

ERIC Educational Resources Information Center

Van Orden, Kimberly A.; Witte, Tracy K.; Cukrowicz, Kelly C.; Braithwaite, Scott R.; Selby, Edward A.; Joiner, Thomas E., Jr.

2010-01-01

Suicidal behavior is a major problem worldwide and, at the same time, has received relatively little empirical attention. This relative lack of empirical attention may be due in part to a relative absence of theory development regarding suicidal behavior. The current article presents the interpersonal theory of suicidal behavior. We propose that…

Occupational rehabilitation in Hong Kong: current status and future needs.

PubMed

Kwok, H K H; Szeto, G P Y; Cheng, A S K; Siu, H; Chan, C C H

2011-03-01

This paper reviews the development of occupational rehabilitation in Hong Kong, both in terms of the science as well as the service for injured workers. Besides, it also reviews the existing Employees' Compensation Ordinance for work injury to illustrate how the policy could influence the success and development of the discipline. Five experienced occupational rehabilitation providers, including 1 occupational medicine specialist, 3 occupational therapists, and 1 physiotherapist critically reviewed the past and current development of occupational rehabilitation in Hong Kong as well as the local contextual factors, which could influence its future development. Since the enactment of the Employees' Compensation Ordinance in the 1950s, there have been progressive improvements in the field of occupational rehabilitation in Hong Kong. Services in the early years were mostly based on the biomedical model, where doctors and patients tended to focus on clinical symptoms and physical pathology when making clinical decisions. Since then, remarkable academic achievements have been made in the field locally, from the validation of clinical instruments for assessment of work capacity, assessment of employment readiness to the evaluation of efficacy of interventional programs for injured workers focusing on work related outcomes. However, there has been a relatively lack of progress in the development of related policies and implementation of related programs for occupational rehabilitation. There is no built in linkage between rehabilitation, compensation and prevention in the current system in Hong Kong, and there is no rehabilitation policy specific to those workers with occupational diseases and injuries. There are still deficiencies in the development and provision of occupational rehabilitation services in Hong Kong. Incorporation of requirements for occupational rehabilitation at the legislation and policy levels should be seriously considered in the future. Besides, the development of the Occupational Medicine subspecialty in the public hospital system in Hong Kong is considered a facilitator to the future development of occupational rehabilitation in Hong Kong.

An Air Force Guide to the System Specification.

DTIC Science & Technology

1981-01-01

basis for sound management plans and decisions to initiate system full-scale development. Related topics include: current problems and questions...such current documents as AFR 800-2 and AFR 57-1. Key elements of coverage include the following: a. Levels of system engineering studies are...equipment and computer program elements of a system are acquired most directly acainst lower-level (configuration item) specifications. b. Current

Recent Advances in Biosensor Development for Foodborne Virus Detection

PubMed Central

Neethirajan, Suresh; Ahmed, Syed Rahin; Chand, Rohit; Buozis, John; Nagy, Éva

2017-01-01

Outbreaks of foodborne diseases related to fresh produce have been increasing in North America and Europe. Viral foodborne pathogens are poorly understood, suffering from insufficient awareness and surveillance due to the limits on knowledge, availability, and costs of related technologies and devices. Current foodborne viruses are emphasized and newly emerging foodborne viruses are beginning to attract interest. To face current challenges regarding foodborne pathogens, a point-of-care (POC) concept has been introduced to food testing technology and device. POC device development involves technologies such as microfluidics, nanomaterials, biosensors and other advanced techniques. These advanced technologies, together with the challenges in developing foodborne virus detection assays and devices, are described and analysed in this critical review. Advanced technologies provide a path forward for foodborne virus detection, but more research and development will be needed to provide the level of manufacturing capacity required. PMID:29071193

Natural language processing-based COTS software and related technologies survey.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stickland, Michael G.; Conrad, Gregory N.; Eaton, Shelley M.

Natural language processing-based knowledge management software, traditionally developed for security organizations, is now becoming commercially available. An informal survey was conducted to discover and examine current NLP and related technologies and potential applications for information retrieval, information extraction, summarization, categorization, terminology management, link analysis, and visualization for possible implementation at Sandia National Laboratories. This report documents our current understanding of the technologies, lists software vendors and their products, and identifies potential applications of these technologies.

Infectious disease complications of combat-related injuries.

PubMed

Murray, Clinton K

2008-07-01

: Strategies currently used to prevent morbidity and mortality associated with combat-related injuries include better training of frontline medical personnel, improved personal protective equipment, and deployment of fast-forward surgical assets with state-of-the-art equipment. These strategies allow patients to survive near-catastrophic injuries, placing a greater emphasis on the medical infrastructure to mitigate short- and long-term complications associated with these injuries. : Wounds have certain characteristics that promote the development of infections: the presence of devitalized tissue, foreign bodies, clots, fluid collections, and contamination of wounds with bacteria from the casualty's skin, the environment, and the hospital. All of these factors culminate in placing the casualty at risk of developing an infection. : This article reviews the lessons learned from combat-related wound infections throughout history and in the current conflicts in Iraq and Afghanistan. Many of the management strategies used to prevent infections of combat-related injuries are applicable to the management of civilian trauma, whether associated with small arms fire or related to natural disasters such as earthquakes or tornadoes.

Are Competitive Materialism and Female Employment Related to International Homicide Rate?

PubMed

Chon, Don Soo

2017-04-01

The institutional anomie theory is a proposal that states competitive materialism, an intense cultural pressure for economic success at any costs, and increased female employment may be related to a high homicide rate. The current work tested this proposition by utilizing homicide data collected from 45 developed and developing countries. Regression results did not support the proposition. Competitive materialism and female employment were not significantly related to the cross-national variation of homicide rates.

Job satisfaction in relation to energy resource consciousness and perceptions of energy utilization in selected Illinois manufacturing firms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haynes, T.S.

1986-01-01

This study was developed through a synthesis and review of literature and research related to the current status of job satisfaction, energy resources, and perceptions of how energy is utilized in the manufacturing work environment. This synthesis and review revolved around several proven contributing factors of job satisfaction, such as age, education, and challenge from work itself. Quality of work life programs and their components are discussed in relation to their impact on job satisfaction. The nature of energy resource utilization is traced back through history with an emphasis on the limitations of current resources and options for the future.more » The review highlights the current debate over what should be the future path of energy resource development. The concept of satisfaction of human needs is reviewed and related to job satisfaction and energy resources. The purpose of this research study was to contribute to the understanding of how perceptions of energy resources relate to job satisfaction. Results of the study indicated that there were no significant differences between an individual's energy resource consciousness and perceptions of energy utilization in the work place, energy resource consciousness and job satisfaction, and job satisfaction and perceptions of energy utilization in the workplace.« less

Rethinking Giftedness and Talent in Sport

ERIC Educational Resources Information Center

Tranckle, Peter; Cushion, Christopher J.

2006-01-01

The purpose of this paper is to understand how gifts are discovered and talents developed within sport. The current literature is critically discussed, highlighting contributions and gaps in current knowledge. Due to issues concerning terminology and the nature versus nurture debate, research on talent faces challenges relating to continuity and…

Future land-use related water demand in California

USGS Publications Warehouse

Wilson, Tamara; Sleeter, Benjamin M.; Cameron, D. Richard

2016-01-01

Water shortages in California are a growing concern amidst ongoing drought, earlier spring snowmelt, projected future climate warming, and currently mandated water use restrictions. Increases in population and land use in coming decades will place additional pressure on already limited available water supplies. We used a state-and-transition simulation model to project future changes in developed (municipal and industrial) and agricultural land use to estimate associated water use demand from 2012 to 2062. Under current efficiency rates, total water use was projected to increase 1.8 billion cubic meters(+4.1%) driven primarily by urbanization and shifts to more water intensive crops. Only if currently mandated 25% reductions in municipal water use are continuously implemented would water demand in 2062 balance to water use levels in 2012. This is the first modeling effort of its kind to examine regional land-use related water demand incorporating historical trends of both developed and agricultural land uses.

Project Management as Related to Weapon Development in Navy Research and Development Organizations.

DTIC Science & Technology

of management . AGILE a current development program, is traced from inception to the present and unique management problems are discussed. The authors...evaluation is based on two standards of measurement: compliance with Department of Defense policy and conformance to generally accepted principles

The Link between Age, Career Goals, and Adaptive Development for Work-Related Learning among Local Government Employees

ERIC Educational Resources Information Center

Tones, Megan; Pillay, Hitendra; Kelly, Kathy

2011-01-01

More recently, lifespan development psychology models of adaptive development have been applied to the workforce to investigate ageing worker and lifespan issues. The current study uses the Learning and Development Survey (LDS) to investigate employee selection and engagement of learning and development goals and opportunities and constraints for…

Avoidant Personality Disorder: a Current Review.

PubMed

Weinbrecht, Anna; Schulze, Lars; Boettcher, Johanna; Renneberg, Babette

2016-03-01

This review focuses on recent research on diagnostic aspects, etiology, and treatment of avoidant personality disorder (AVPD). Current studies stress the close relation between AVPD and social anxiety disorder, the influence of genetic factors in the development of AVPD, and the relative stability of symptoms. Treatment approaches should target the pervasive patterns of social inhibition, feelings of inadequacy, and hypersensitivity to negative evaluation. Empirical evidence for cognitive-behavior and schema therapy is promising. Few other therapeutic approaches have been developed, but until now, these have only been investigated in case studies. We conclude that AVPD qualifies as a neglected disorder and that more research specifically on avoidant personality disorder symptoms and its treatment is needed.

Examining Science Teachers' Development of Interdisciplinary Science Inquiry Pedagogical Knowledge and Practices

ERIC Educational Resources Information Center

Chowdhary, Bhawna; Liu, Xiufeng; Yerrick, Randy; Smith, Erica; Grant, Brooke

2014-01-01

The current literature relates to how teachers develop knowledge and practice of science inquiry, but little has been reported on how teachers develop interdisciplinary science inquiry (ISI) knowledge and practice. This study examines the effect of university research experiences, ongoing professional development, and in-school support on…

Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research.

PubMed

Pawitwar, Shashank S; Dhar, Supurna; Tiwari, Sneham; Ojha, Chet Raj; Lapierre, Jessica; Martins, Kyle; Rodzinski, Alexandra; Parira, Tiyash; Paudel, Iru; Li, Jiaojiao; Dutta, Rajib Kumar; Silva, Monica R; Kaushik, Ajeet; El-Hage, Nazira

2017-09-01

There is growing evidence that Zika virus (ZIKV) infection is linked with activation of Guillan-Barré syndrome (GBS) in adults infected with the virus and microcephaly in infants following maternal infection. With the recent outpour in publications by numerous research labs, the association between microcephaly in newborns and ZIKV has become very apparent in which large numbers of viral particles were found in the central nervous tissue of an electively aborted microcephalic ZIKV-infected fetus. However, the underlying related mechanisms remain poorly understood. Thus, development of ZIKV-infected animal models are urgently required. The need to develop drugs and vaccines of high efficacy along with efficient diagnostic tools for ZIKV treatment and management raised the demand for a very selective animal model for exploring ZIKV pathogenesis and related mechanisms. In this review, we describe recent advances in animal models developed for studying ZIKV pathogenesis and evaluating potential interventions against human infection, including during pregnancy. The current research directions and the scientific challenges ahead in developing effective vaccines and therapeutics are also discussed.

DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications

PubMed Central

Miranda-Duarte, Antonio

2018-01-01

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA. Objective: This review is focused on the current status of DNA methylation studies related to OA pathogenesis. Method: A review of the literature was conducted on searching in PUBMED for original papers on DNA methylation in OA. Conclusion: The DNA methylation research of loci related to OA pathogenesis has shown a correlation between methylation and gene repression; however, there are some exceptions to this rule. Recently, the development of genome-wide methylation and genome-wide hydroxymethylation profiles has demonstrated that several genes previously associated with OA can have changes in their methylation status, favoring the development of the disease, and these have even shown the role of other epigenetic markers. PMID:29682093

History of research on modelling gypsy moth population ecology

Treesearch

J. J. Colbert

1991-01-01

History of research to develop models of gypsy moth population dynamics and some related studies are described. Empirical regression-based models are reviewed, and then the more comprehensive process models are discussed. Current model- related research efforts are introduced.

Current Problems of Educational Development in Nigeria

ERIC Educational Resources Information Center

Adeyinka, A. A.

1975-01-01

A discussion of problems of educational development in Nigeria focusingon the responsibility for and control of the nations' educational system, its diversification, the need to relate the schools' curricula to national manpower needs, and the issue of finance. (EH)

Development of surface friction guidelines for LADOTD : research project capsule.

DOT National Transportation Integrated Search

2011-02-01

The current friction guideline of the Louisiana Department of : Transportation and Development (LADOTD) for a wearing course mixture : design deals with the polished stone value (PSV) of coarse aggregate : (which is a relative British Pendulum skid-r...

Studies related to ocean dynamics. Task 3.2: Aircraft Field Test Program to investigate the ability of remote sensing methods to measure current/wind-wave interactions

NASA Technical Reports Server (NTRS)

Huang, N. E.; Flood, W. A.; Brown, G. S.

1975-01-01

The feasibility of remote sensing of current flows in the ocean and the remote sensing of ocean currents by backscattering cross section techniques was studied. It was established that for capillary waves, small scale currents could be accurately measured through observation of wave kinematics. Drastic modifications of waves by changing currents were noted. The development of new methods for the measurement of capillary waves are discussed. Improvement methods to resolve data processing problems are suggested.

Review of sports-related concussion: Potential for application in military settings.

PubMed

Lew, Henry L; Thomander, Darryl; Chew, Kelvin T L; Bleiberg, Joseph

2007-01-01

This article reviews current issues and practices in the assessment and clinical management of sports-related concussion. An estimated 300,000 sports-related concussions occur annually in the United States. Much of what has been learned about concussion in the sports arena can be applied to the diagnosis and management of concussion in military settings. Current military guidelines for assessing and managing concussion in war zones incorporate information and methods developed through sports-concussion research. We discuss the incidence, definition, and diagnosis of concussion; concussion grading scales; sideline evaluation tools; neuropsychological assessment; return-to-action criteria; and complications of concussion.

Tactical Satellite-3 Mission Overview and Initial Lessons Learned (Postprint)

DTIC Science & Technology

2013-03-01

current buses. The spacecraft bus includes the main structure; attitude control system (reaction wheels and torque rods); the thermal protection...Specific key areas are the relatively rapid checkout of the spacecraft and lessons from the responsive space development. 15. SUBJECT TERMS...relatively rapid checkout of the spacecraft and lessons from the responsive space development. INTRODUCTION The Tactical Satellite 3 mission was a

Lower-Dark-Current, Higher-Blue-Response CMOS Imagers

NASA Technical Reports Server (NTRS)

Pain, Bedabrata; Cunningham, Thomas; Hancock, Bruce

2008-01-01

Several improved designs for complementary metal oxide/semiconductor (CMOS) integrated-circuit image detectors have been developed, primarily to reduce dark currents (leakage currents) and secondarily to increase responses to blue light and increase signal-handling capacities, relative to those of prior CMOS imagers. The main conclusion that can be drawn from a study of the causes of dark currents in prior CMOS imagers is that dark currents could be reduced by relocating p/n junctions away from Si/SiO2 interfaces. In addition to reflecting this conclusion, the improved designs include several other features to counteract dark-current mechanisms and enhance performance.

Understanding Context: Cultural, Relational, & Psychological Interactions in Self-Authorship Development

ERIC Educational Resources Information Center

Pizzolato, Jane Elizabeth; Nguyen, Tu-Lien Kim; Johnston, Marc P.; Wang, Sherry

2012-01-01

Existing research points toward dissonance as the primary catalyst in self-authorship development. This study investigated the cultural relevance of current conceptions of dissonance's role in self-authorship development. A total of 166 participants of color were recruited from three large public research universities from different regions in the…

The Career Development of Women: Helping Cinderella Lose Her Complex.

ERIC Educational Resources Information Center

Borman, Christopher A.; Guido-DiBrito, Florence

1986-01-01

Describes the current status of women in the workplace, the internal and external variables that are related specifically to the career development of women, and several effective counseling strategies, programs, and resources that might be used in assisting women to overcome barriers in the career development process. (CT)

Promising Directions for Research and Development in Early Childhood Education.

ERIC Educational Resources Information Center

Elliott, David L.

A survey of research and development studies currently needed in early childhood education stresses child development and its relation to instruction. Topics which have been discussed are perception, oral language, concept formation, learning set, motivation, and the psychology of learning. Universities and public school systems working together…

Challenges and future in vaccines, drug development, and immunomodulatory therapy.

PubMed

Kling, Heather M; Nau, Gerard J; Ross, Ted M; Evans, Thomas G; Chakraborty, Krishnendu; Empey, Kerry M; Flynn, JoAnne L

2014-08-01

Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The "Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy" session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials.

National Toxicology Program: Review of current DHHS, DOE, and EPA research related to toxicology, Fiscal Year 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-06-01

The report represents responses by agencies of DHHS, and by DOE and EPA, to requests by the Director of NTP for information on agency programs in basic toxicology research, toxicology testing, and toxicology methods development. Information on dollar and manpower support for agency activities in basic toxicology research, toxicology testing, and toxicology methods development, by DHHS, DOE and EPA, is summarized on pages 4 to 10. All agencies were requested to provide summary information on their programs related to toxicology methods development, whether essential or peripheral to their missions. The information provided in response to the request is summarized inmore » tables on pages 48 to 81. Information was provided on chemical compounds currently being studied for their toxicological properties in intramural laboratories, or on contracts, or through grants.« less

Research related to variable sweep aircraft development

NASA Technical Reports Server (NTRS)

Polhamus, E. C.; Toll, T. A.

1981-01-01

Development in high speed, variable sweep aircraft research is reviewed. The 1946 Langley wind tunnel studies related to variable oblique and variable sweep wings and results from the X-5 and the XF1OF variable sweep aircraft are discussed. A joint program with the British, evaluation of the British "Swallow", development of the outboard pivot wing/aft tail configuration concept by Langley, and the applied research program that followed and which provided the technology for the current, variable sweep military aircraft is outlined. The relative state of variable sweep as a design option is also covered.

Improved prediction models for PCC pavement performance-related specifications, volume I : final report.

DOT National Transportation Integrated Search

2000-12-01

The current performance-related specifications (PRS) methodology has been under development by the Federal : Highway Administration (FHWA) for several years and has now reached a level at which it can be implemented by : State highway agencies. PRS f...

Reusable Rocket Engine Advanced Health Management System. Architecture and Technology Evaluation: Summary

NASA Technical Reports Server (NTRS)

Pettit, C. D.; Barkhoudarian, S.; Daumann, A. G., Jr.; Provan, G. M.; ElFattah, Y. M.; Glover, D. E.

1999-01-01

In this study, we proposed an Advanced Health Management System (AHMS) functional architecture and conducted a technology assessment for liquid propellant rocket engine lifecycle health management. The purpose of the AHMS is to improve reusable rocket engine safety and to reduce between-flight maintenance. During the study, past and current reusable rocket engine health management-related projects were reviewed, data structures and health management processes of current rocket engine programs were assessed, and in-depth interviews with rocket engine lifecycle and system experts were conducted. A generic AHMS functional architecture, with primary focus on real-time health monitoring, was developed. Fourteen categories of technology tasks and development needs for implementation of the AHMS were identified, based on the functional architecture and our assessment of current rocket engine programs. Five key technology areas were recommended for immediate development, which (1) would provide immediate benefits to current engine programs, and (2) could be implemented with minimal impact on the current Space Shuttle Main Engine (SSME) and Reusable Launch Vehicle (RLV) engine controllers.

Electrical Counting and Sizing of Mammalian Cells in Suspension

PubMed Central

Gregg, E. C.; Steidley, K. David

1965-01-01

A recently developed method of determining the number and size of particles suspended in a conducting solution is to pump the suspension through a small orifice having an immersed electrode on each side to supply electrical current. The current changes due to the passage of particles of resistivity different from that of the solution. Theoretical expressions are developed which relate the current change caused by such particles to their volume and shape. It is found that most biological cells may be treated as dielectric particles whose capacitive effects are negligible. Electrolytic tank measurements on models confirm the theoretical development, and electric field plots of model orifices are used to predict the observed pulse shapes. An equivalent circuit of the orifice-electrode system is analyzed and shows that the current pulse may be made conductivity-independent when observed with a zero input impedance amplifier. PMID:5861698

Current Status of the Nitrogen Oxygen Recharge System

NASA Technical Reports Server (NTRS)

Dick, Brandon

2011-01-01

This paper presents an overview of the Nitrogen Oxygen Recharge System (NORS) to date and the current development status of the system. NORS is an element of the International Space Station (ISS) Environmental Control and Life Support Systems (ECLSS) used to resupply the ISS with Nitrogen and Oxygen following the impending retirement of the Space Shuttle. The paper will discuss why NASA is developing NORS, including a summary of other concepts considered, and other related concepts currently being developed by NASA. The current system architecture will be described, along with a summary of the current design of the NORS. The overall programmatic schedule of the NORS in the context of the upcoming shuttle retirement and future launch vehicle development will also be presented. Finally, the paper will examine the significant technical challenges encountered during the requirements and preliminary design phase of NORS development. A key challenge to the development of NORS is the international shipment - and associated regulations - of pressurized Oxygen, which is necessary due to the use of launch vehicles based in Japan and French Guiana to send NORS gasses to the ISS. The storage and use of relatively large quantities of high pressure (41,000 kPa) Oxygen and Nitrogen within the ISS, which is unprecedented both on the ISS and other space vehicles, has had a significant impact on the design and architecture of the system. The high pressure of the system also poses unique thermal considerations, which has led to the development of a heater system for thermal conditioning of high pressure gas to avoid thermal impacts on downstream hardware. The on-orbit envelope allocated to the NORS has changed (gotten smaller) and has impacted both the design and architecture of the system. Finally, the balance of safety considerations associated with these high pressure gasses, particularly high pressure Oxygen, with the functionality of the system has profoundly impacted the form of the system and will be discussed.

Unimanual Performance across the Age Span

ERIC Educational Resources Information Center

Bryden, P.J.; Roy, E.A.

2005-01-01

The purpose of the current investigation was to examine the age-related changes in the performance of the two hands on the Annett pegboard (Annett, 1970). The current study was part of a large-scale study investigating the development of unimanual and bimanual performance. Three hundred and two right-handed individuals participated in the present…

The Tense Situation of Slavic: Past, Present, Future.

ERIC Educational Resources Information Center

Cooper, Henry R., Jr.

1998-01-01

Discusses the challenges and difficulties of Slavic languages, a field that is notoriously cyclical and is currently at the bottom of a cycle. The article chronicles the history of Slavic studies in relation to political developments since World War II, draws parallels between current trends in Slavic and other modern language programs, and sees…

Second Language Vocabulary Assessment: Current Practices and New Directions

ERIC Educational Resources Information Center

Read, John

2007-01-01

This paper surveys some current developments in second language vocabulary assessment, with particular attention to the ways in which computer corpora can provide better quality information about the frequency of words and how they are used in specific contexts. The relative merits of different word lists are discussed, including the Academic Word…

The Team-Based Internal Supervision System Development for the Primary Schools under the Office of the Basic Education Commission

ERIC Educational Resources Information Center

Tubsuli, Nattapong; Julsuwan, Suwat; Tesaputa, Kowat

2017-01-01

Internal supervision in the school is currently experiencing various problems. Supervision preparation problems are related to: lacking of supervision plan, lacking of holistic and systematic planning, and lacking of analysis in current conditions or requirements. While supervision operational problems are included: lacking of supervision…

Commentaries on Research in Instructional Media. An Examination of Conceptual Schemes.

ERIC Educational Resources Information Center

Salomon, Gavriel, Ed.; Snow, Richard E., Ed.

1970-01-01

Papers which explore the aspects of current work in instructional technology and promote research and development in the field are collected in this bulletin. An introductory paper provides some general perceptives on the current state of instructional technology in relation to the contemporary educational scene and the various problems and…

The Challenges Facing School Governing Bodies in England: A "Perfect Storm"?

ERIC Educational Resources Information Center

James, Chris; Brammer, Steve; Connolly, Michael; Spicer, David Eddy; James, Jane; Jones, Jeff

2013-01-01

The governing bodies of publicly funded schools in England are currently facing a number of substantive challenges of various kinds. Many of the challenges are long-standing, while others relate to the current context for governing wrought by recent education policy developments initiated by central government. A number of the challenges are…

Interferometer for Space Station Windows

NASA Technical Reports Server (NTRS)

Hall, Gregory

2003-01-01

Inspection of space station windows for micrometeorite damage would be a difficult task insitu using current inspection techniques. Commercially available optical profilometers and inspection systems are relatively large, about the size of a desktop computer tower, and require a stable platform to inspect the test object. Also, many devices currently available are designed for a laboratory or controlled environments requiring external computer control. This paper presents an approach using a highly developed optical interferometer to inspect the windows from inside the space station itself using a self- contained hand held device. The interferometer would be capable as a minimum of detecting damage as small as one ten thousands of an inch in diameter and depth while interrogating a relatively large area. The current developmental state of this device is still in the proof of concept stage. The background section of this paper will discuss the current state of the art of profilometers as well as the desired configuration of the self-contained, hand held device. Then, a discussion of the developments and findings that will allow the configuration change with suggested approaches appearing in the proof of concept section.

NASA Glenn Research Center Electrochemistry Branch Battery and Fuel Cell Development Overview

NASA Technical Reports Server (NTRS)

Manzo, Michelle A.

2011-01-01

This presentation covers an overview of NASA Glenn s history and heritage in the development of electrochemical systems for aerospace applications. Current developments related to batteries and fuel cells are addressed. Specific areas of focus are Li-ion batteries and Polymer Electrolyte Membrane Fuel cells systems and their development for future Exploration missions.

Determining the near-surface current profile from measurements of the wave dispersion relation

NASA Astrophysics Data System (ADS)

Smeltzer, Benjamin; Maxwell, Peter; Aesøy, Eirik; Ellingsen, Simen

2017-11-01

The current-induced Doppler shifts of waves can yield information about the background mean flow, providing an attractive method of inferring the current profile in the upper layer of the ocean. We present measurements of waves propagating on shear currents in a laboratory water channel, as well as theoretical investigations of inversion techniques for determining the vertical current structure. Spatial and temporal measurements of the free surface profile obtained using a synthetic Schlieren method are analyzed to determine the wave dispersion relation and Doppler shifts as a function of wavelength. The vertical current profile can then be inferred from the Doppler shifts using an inversion algorithm. Most existing algorithms rely on a priori assumptions of the shape of the current profile, and developing a method that uses less stringent assumptions is a focus of this study, allowing for measurement of more general current profiles. The accuracy of current inversion algorithms are evaluated by comparison to measurements of the mean flow profile from particle image velocimetry (PIV), and a discussion of the sensitivity to errors in the Doppler shifts is presented.

Remote Sensing of Drought: Progress and Opportunities for Improving Drought Monitoring and Prediction

NASA Astrophysics Data System (ADS)

AghaKouchak, A.; Huning, L. S.; Love, C. A.; Farahmand, A.

2017-12-01

This presentation surveys current and emerging drought monitoring approaches using satellite remote sensing observations from climatological and ecosystem perspectives. Satellite observations that are not currently used for operational drought monitoring, such as near-surface air relative humidity and water vapor, provide opportunities to improve early drought warning. Current and future satellite missions offer opportunities to develop composite and multi-indicator drought models. This presentation describes how different satellite observations can be combined for overall drought development and impact assessment. Finally, we provide an overview of the research gaps and challenges that are facing us ahead in the remote sensing of drought.

NASA Space Flight Human-System Standard Human Factors, Habitability, and Environmental Health

NASA Technical Reports Server (NTRS)

Holubec, Keith; Connolly, Janis

2010-01-01

This slide presentation reviews the history, and development of NASA-STD-3001, NASA Space Flight Human-System Standard Human Factors, Habitability, and Environmental Health, and the related Human Integration Design Handbook. Currently being developed from NASA-STD-3000, this project standard currently in review will be available in two volumes, (i.e., Volume 1 -- VCrew Health and Volume 2 -- Human Factors, Habitability, and Environmental Health) and the handbook will be both available as a pdf file and as a interactive website.

The Serpent Monte Carlo Code: Status, Development and Applications in 2013

NASA Astrophysics Data System (ADS)

Leppänen, Jaakko; Pusa, Maria; Viitanen, Tuomas; Valtavirta, Ville; Kaltiaisenaho, Toni

2014-06-01

The Serpent Monte Carlo reactor physics burnup calculation code has been developed at VTT Technical Research Centre of Finland since 2004, and is currently used in 100 universities and research organizations around the world. This paper presents the brief history of the project, together with the currently available methods and capabilities and plans for future work. Typical user applications are introduced in the form of a summary review on Serpent-related publications over the past few years.

Current-events knowledge in adults: an investigation of age, intelligence, and nonability determinants.

PubMed

Beier, M E; Ackerman, P L

2001-12-01

This study expanded the scope of knowledge typically included in intellectual assessment to incorporate domains of current-events knowledge from the 1930s to the 1990s across the areas of art/humanities, politics/economics, popular culture, and nature/science/technology. Results indicated that age of participants was significantly and positively related to knowledge about current events. Moreover, fluid intelligence was a less effective predictor of knowledge levels than was crystallized intelligence. Personality (i.e. Openness to Experience) and self-concept were also positively related to current-events knowledge. The results are consistent with an investment theory of adult intellect, which views development as an ongoing outcome of the combined influences of intelligence-as-process, personality, and interests, leading to intelligence-as-knowledge (P. L. Ackerman, 1996b).

Icing Branch Current Research Activities in Icing Physics

NASA Technical Reports Server (NTRS)

Vargas, Mario

2009-01-01

Current development: A grid block transformation scheme which allows the input of grids in arbitrary reference frames, the use of mirror planes, and grids with relative velocities has been developed. A simple ice crystal and sand particle bouncing scheme has been included. Added an SLD splashing model based on that developed by William Wright for the LEWICE 3.2.2 software. A new area based collection efficiency algorithm will be incorporated which calculates trajectories from inflow block boundaries to outflow block boundaries. This method will be used for calculating and passing collection efficiency data between blade rows for turbo-machinery calculations.

New Developments in Education for the Seventies.

ERIC Educational Resources Information Center

Spaulding, Seth

Theories relating to proposed improvements in education are discussed. Changes in curricula, contributions of fields such as psychology, and issues currently being debated are given consideration. Innovative models and approaches are proposed, and several interesting speculations are offered related to the future of education. Following the…

Relative efficacy of drugs: an emerging issue between regulatory agencies and third-party payers.

PubMed

Eichler, Hans-Georg; Bloechl-Daum, Brigitte; Abadie, Eric; Barnett, David; König, Franz; Pearson, Steven

2010-04-01

Drug regulatory agencies have traditionally assessed the quality, safety and efficacy of drugs, and the current paradigm dictates that a new drug should be licensed when the benefits outweigh the risks. By contrast, third-party payers base their reimbursement decisions predominantly on the health benefits of the drug relative to existing treatment options (termed relative efficacy; RE). Over the past decade, the role of payers has become more prominent, and time-to-market no longer means time-to-licensing but time-to-reimbursement. Companies now have to satisfy the sometimes divergent needs of both regulators and payers, and to address RE during the pre-marketing stages. This article describes the current political background to the RE debate and presents the scientific and methodological challenges as they relate to RE assessment. In addition, we explain the impact of RE on drug development, and speculate on future developments and actions that are likely to be required from key players.

Development of Water Quality Modeling in the United States

EPA Science Inventory

This presentation describes historical trends in water quality model development in the United States, reviews current efforts, and projects promising future directions. Water quality modeling has a relatively long history in the United States. While its origins lie in the work...

Status and Significance of Credentialing.

ERIC Educational Resources Information Center

Musgrave, Dorothea

1984-01-01

Discusses the current status, significance, and future of credentialing in the field of environmental health. Also discusses four phases of a Bureau of Health Professions (BHP) Credentialing Program and BHP-funded projects related to their development and implementation. Phases include role delineation, resources development, examination…

Integrated Child Development in Rural China.

ERIC Educational Resources Information Center

Xie, Qing; Young, Mary Eming

Since two thirds of the country's children reside in the countryside, improving child development services in rural areas is one of China's most pressing concerns. This report details the current situation of children in rural and urban China and identifies problems related to child development. The report also presents evidence of the effect of…

Career-Related Parental Support for Vocational School Students in China

ERIC Educational Resources Information Center

Zhang, Jiahong; Yuen, Mantak; Chen, Gaowei

2015-01-01

Career-related parental support plays an essential role in the process of promoting young people's career development. Currently, research on career-related support from parents in China is still fairly limited; but at a time when the employment situation in China is changing rapidly, it is considered especially important to study this topic with…

Assessing Adults' Career Exploration: Development and Validation of the Vocational and Maternal Identity Exploration Scales

ERIC Educational Resources Information Center

Gross-Spector, Michal; Cinamon, Rachel Gali

2018-01-01

To promote our theoretical understanding regarding the exploration process during adulthood, the current study focusses on this process as it relates to work and family life roles and the relations between them, during the transition to motherhood. Two instruments assessing vocational and maternal exploration, relating to self and environment…

The Convoy Model: Explaining Social Relations From a Multidisciplinary Perspective

PubMed Central

Antonucci, Toni C.

2014-01-01

Purpose of the Study: Social relations are a key aspect of aging and the life course. In this paper, we trace the scientific origins of the study of social relations, focusing in particular on research grounded in the convoy model. Design and Methods: We first briefly review and critique influential historical studies to illustrate how the scientific study of social relations developed. Next, we highlight early and current findings grounded in the convoy model that have provided key insights into theory, method, policy, and practice in the study of aging. Results: Early social relations research, while influential, lacked the combined approach of theoretical grounding and methodological rigor. Nevertheless, previous research findings, especially from anthropology, suggested the importance of social relations in the achievement of positive outcomes. Considering both life span and life course perspectives and grounded in a multidisciplinary perspective, the convoy model was developed to unify and consolidate scattered evidence while at the same time directing future empirical and applied research. Early findings are summarized, current evidence presented, and future directions projected. Implications: The convoy model has provided a useful framework in the study of aging, especially for understanding predictors and consequences of social relations across the life course. PMID:24142914

Conductance of single microRNAs chains related to the autism spectrum disorder

NASA Astrophysics Data System (ADS)

Oliveira, J. I. N.; Albuquerque, E. L.; Fulco, U. L.; Mauriz, P. W.; Sarmento, R. G.; Caetano, E. W. S.; Freire, V. N.

2014-09-01

The charge transport properties of single-stranded microRNAs (miRNAs) chains associated to autism disorder were investigated. The computations were performed within a tight-binding model, together with a transfer matrix technique, with ionization energies and hopping parameters obtained by quantum chemistry method. Current-voltage (I× V) curves of twelve miRNA chains related to the autism spectrum disorders were calculated and analysed. We have obtained both semiconductor and insulator behavior, and a relationship between the current intensity and the autism-related miRNA bases sequencies, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism disorders.

The impact of poverty on the development of brain networks

PubMed Central

Lipina, Sebastián J.; Posner, Michael I.

2012-01-01

Although the study of brain development in non-human animals is an old one, recent imaging methods have allowed non-invasive studies of the gray and white matter of the human brain over the lifespan. Classic animal studies show clearly that impoverished environments reduce cortical gray matter in relation to complex environments and cognitive and imaging studies in humans suggest which networks may be most influenced by poverty. Studies have been clear in showing the plasticity of many brain systems, but whether sensitivity to learning differs over the lifespan and for which networks is still unclear. A major task for current research is a successful integration of these methods to understand how development and learning shape the neural networks underlying achievements in literacy, numeracy, and attention. This paper seeks to foster further integration by reviewing the current state of knowledge relating brain changes to behavior and indicating possible future directions. PMID:22912613

Energy sources for Nigeria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Okoroji, C.E.I.

1982-09-01

A public consensus has developed on the need for national energy policies and better planning in the utilization of energy resources in Nigeria. A look at Nigeria's energy future is timely as a period of rapid technological growth and industrial development begins. At the present time, Nigeria exports a relatively high percentage (92%) of the petroleum produced annually. In addition, about 95% of all produced natural gas is flared. Only a relatively minor fraction of the coal produced is used and the rest exported to West African countries. Water power in Nigeria is not yet fully developed. Although the depositsmore » of uranium and oil sand may be substantial, the reserves are not currently known. The proportions in which mineral fuels are used are not related to their relative abundance. Based on present production rates, domestic reserves of petroleum will last 20 years, those of natural gas 63 years, and those of coal 1503 years. Nigeria is not currently and is not likely to become self-sufficient in terms of energy requirements. During the past decade, Nigeria's population has increased by 28.4%. Of vital concern for the immediate future in Nigeria are the demands on energy consumption and mineral resources resulting from increasing population pressure.« less

Development of a database system for near-future climate change projections under the Japanese National Project SI-CAT

NASA Astrophysics Data System (ADS)

Nakagawa, Y.; Kawahara, S.; Araki, F.; Matsuoka, D.; Ishikawa, Y.; Fujita, M.; Sugimoto, S.; Okada, Y.; Kawazoe, S.; Watanabe, S.; Ishii, M.; Mizuta, R.; Murata, A.; Kawase, H.

2017-12-01

Analyses of large ensemble data are quite useful in order to produce probabilistic effect projection of climate change. Ensemble data of "+2K future climate simulations" are currently produced by Japanese national project "Social Implementation Program on Climate Change Adaptation Technology (SI-CAT)" as a part of a database for Policy Decision making for Future climate change (d4PDF; Mizuta et al. 2016) produced by Program for Risk Information on Climate Change. Those data consist of global warming simulations and regional downscaling simulations. Considering that those data volumes are too large (a few petabyte) to download to a local computer of users, a user-friendly system is required to search and download data which satisfy requests of the users. We develop "a database system for near-future climate change projections" for providing functions to find necessary data for the users under SI-CAT. The database system for near-future climate change projections mainly consists of a relational database, a data download function and user interface. The relational database using PostgreSQL is a key function among them. Temporally and spatially compressed data are registered on the relational database. As a first step, we develop the relational database for precipitation, temperature and track data of typhoon according to requests by SI-CAT members. The data download function using Open-source Project for a Network Data Access Protocol (OPeNDAP) provides a function to download temporally and spatially extracted data based on search results obtained by the relational database. We also develop the web-based user interface for using the relational database and the data download function. A prototype of the database system for near-future climate change projections are currently in operational test on our local server. The database system for near-future climate change projections will be released on Data Integration and Analysis System Program (DIAS) in fiscal year 2017. Techniques of the database system for near-future climate change projections might be quite useful for simulation and observational data in other research fields. We report current status of development and some case studies of the database system for near-future climate change projections.

Measuring neural and behavioral activity during ongoing computerized social interactions: an examination of event-related brain potentials.

PubMed

Themanson, Jason R

2014-11-15

Social exclusion is a complex social phenomenon with powerful negative consequences. Given the impact of social exclusion on mental and emotional health, an understanding of how perceptions of social exclusion develop over the course of a social interaction is important for advancing treatments aimed at lessening the harmful costs of being excluded. To date, most scientific examinations of social exclusion have looked at exclusion after a social interaction has been completed. While this has been very helpful in developing an understanding of what happens to a person following exclusion, it has not helped to clarify the moment-to-moment dynamics of the process of social exclusion. Accordingly, the current protocol was developed to obtain an improved understanding of social exclusion by examining the patterns of event-related brain activation that are present during social interactions. This protocol allows greater precision and sensitivity in detailing the social processes that lead people to feel as though they have been excluded from a social interaction. Importantly, the current protocol can be adapted to include research projects that vary the nature of exclusionary social interactions by altering how frequently participants are included, how long the periods of exclusion will last in each interaction, and when exclusion will take place during the social interactions. Further, the current protocol can be used to examine variables and constructs beyond those related to social exclusion. This capability to address a variety of applications across psychology by obtaining both neural and behavioral data during ongoing social interactions suggests the present protocol could be at the core of a developing area of scientific inquiry related to social interactions.

Improved prediction models for PCC pavement performance-related specifications, volume II : PaveSpec 3.0 user's guide.

DOT National Transportation Integrated Search

2001-12-01

The current performance-related specifications (PRS) methodology has been under development by the Federal : Highway~Administration (FI-IWA) for several years and has now reached a level at which it can be implemented by : State highway agencies. PRS...

22 CFR 216.10 - Records and reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Records and reports. 216.10 Section 216.10 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ENVIRONMENTAL PROCEDURES § 216.10 Records and reports. Each Agency Bureau will maintain a current list of activities for which Environmental Assessments...

Collection Development; Making Room for the Recovery Boom.

ERIC Educational Resources Information Center

Dowd, Alice

1992-01-01

Briefly describes the current recovery movement with its support groups for addicts and their relatives and friends. The response of publishers to this movement is also noted. An annotated bibliography lists resources for information related to alcoholism, codependency, drug addiction, dysfunctional families, food addiction, religious addiction,…

Educational Planning for the Future Development of Pasco-Hernando Community College.

ERIC Educational Resources Information Center

McGuffey, C. W.; And Others

The purpose of this study was to develop a long-range educational plan for the future development and expansion of the current program and facilities of Pasco-Hernando Community College. An analysis has been made of available data and related information as a basis for the preparation of a generalized plan to guide the future development of the…

78 FR 59648 - Bureau of Economic Analysis Advisory Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-27

... presented more effectively for current economic analysis and recent statistical developments in national... with disabilities. Requests for foreign language interpretation or other auxiliary aids should be... September 2, 1999. The Committee advises the Director of BEA on matters related to the development and...

Methodology to Estimate the Quantity, Composition, and ...

EPA Pesticide Factsheets

This report, Methodology to Estimate the Quantity, Composition and Management of Construction and Demolition Debris in the US, was developed to expand access to data on CDD in the US and to support research on CDD and sustainable materials management. Since past US EPA CDD estimates have been limited to building-related CDD, a goal in the development of this methodology was to use data originating from CDD facilities and contractors to better capture the current picture of total CDD management, including materials from roads, bridges and infrastructure. This report, Methodology to Estimate the Quantity, Composition and Management of Construction and Demolition Debris in the US, was developed to expand access to data on CDD in the US and to support research on CDD and sustainable materials management. Since past US EPA CDD estimates have been limited to building-related CDD, a goal in the development of this methodology was to use data originating from CDD facilities and contractors to better capture the current picture of total CDD management, including materials from roads, bridges and infrastructure.

Intermediate Teachers' Perceptions of Reading Instruction Strategies and Professional Development Needs

ERIC Educational Resources Information Center

Joyner, Barbara

2017-01-01

In 1 urban Tennessee school, students in Grades 3 through 5 had not met adequate yearly progress in reading for the past 5 years. The purpose of this case study was to explore teachers' perceptions of current district-recommended teaching practice in reading. The research questions related to current instructional strategies, teaching practices,…

Application of Magnetic Suspension and Balance Systems to Ultra-High Reynolds Number Facilities

NASA Technical Reports Server (NTRS)

Britcher, Colin P.

1996-01-01

The current status of wind tunnel magnetic suspension and balance system development is briefly reviewed. Technical work currently underway at NASA Langley Research Center is detailed, where it relates to the ultra-high Reynolds number application. The application itself is addressed, concluded to be quite feasible, and broad design recommendations given.

New Currents in Education: A Preliminary Review. QuEST Paper 10.

ERIC Educational Resources Information Center

Bhaerman, Robert D.

This booklet describes nine "new currents" in education with the recommendation that local and state federations of the American Federation of Teachers create QuEST committees of teachers to study the implications of all these issues and develop statements and QuEST action programs on them as they relate to local and state situations. The issues…

Development and Current Status of Special Education in Korea

ERIC Educational Resources Information Center

Park, Young-Kyoon

2005-01-01

This paper deals with the developmental history and the current situation of special education in Korea. Special Education began in the late 1800s by the commitment of missionaries from the West. Special Education in Korea is well defined by the related laws and regulations; however, Special Education still needs lots of innovative efforts to…

Recent trends related to the use of formal methods in software engineering

NASA Technical Reports Server (NTRS)

Prehn, Soren

1986-01-01

An account is given of some recent developments and trends related to the development and use of formal methods in software engineering. Ongoing activities in Europe are focussed on, since there seems to be a notable difference in attitude towards industrial usage of formal methods in Europe and in the U.S. A more detailed account is given of the currently most widespread formal method in Europe: the Vienna Development Method. Finally, the use of Ada is discussed in relation to the application of formal methods, and the potential for constructing Ada-specific tools based on that method is considered.

Application of SAE ARP4754A to Flight Critical Systems

NASA Technical Reports Server (NTRS)

Peterson, Eric M.

2015-01-01

This report documents applications of ARP4754A to the development of modern computer-based (i.e., digital electronics, software and network-based) aircraft systems. This study is to offer insight and provide educational value relative to the guidelines in ARP4754A and provide an assessment of the current state-of-the- practice within industry and regulatory bodies relative to development assurance for complex and safety-critical computer-based aircraft systems.

Recent developments in L-asparaginase discovery and its potential as anticancer agent.

PubMed

Shrivastava, Abhinav; Khan, Abdul Arif; Khurshid, Mohsin; Kalam, Mohd Abul; Jain, Sudhir K; Singhal, Pradeep K

2016-04-01

L-Asparaginase (EC3.5.1.1) is an enzyme, which is used for treatment of acute lymphoblastic leukaemia (ALL) and other related blood cancers from a long time. This enzyme selectively hydrolyzes the extracellular amino acid L-asparagine into L-aspartate and ammonia, leading to nutritional deficiencies, protein synthesis inhibition, and ultimately death of lymphoblastic cells by apoptosis. Currently, bacterial asparaginases are used for treatment purpose but offers scepticism due to a number of toxicities, including thrombosis, pancreatitis, hyperglycemia, and hepatotoxicity. Resistance towards bacterial asparaginase is another major disadvantage during cancer management. This situation attracted attention of researchers towards alternative sources of L-asparaginase, including plants and fungi. Present article discusses about potential of L-asparaginase as an anticancer agent, its mechanism of action, and adverse effects related to current asparaginase formulations. This article also provides an outlook for recent developments in L-asparaginase discovery from alternative sources and their potential as a less toxic alternative to current formulations. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

System Verification Through Reliability, Availability, Maintainability (RAM) Analysis & Technology Readiness Levels (TRLs)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Emmanuel Ohene Opare, Jr.; Charles V. Park

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is authored by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype fourth generation nuclear reactor to meet the needs of the 21st Century. A section in this document proposes that the NGNP will provide heat for process heat applications. As with all large projects developing and deploying new technologies, the NGNP is expected to meet high performance and availability targets relative to current state of the art systems and technology. One requirement for the NGNP is to provide heatmore » for the generation of hydrogen for large scale productions and this process heat application is required to be at least 90% or more available relative to other technologies currently on the market. To reach this goal, a RAM Roadmap was developed highlighting the actions to be taken to ensure that various milestones in system development and maturation concurrently meet required availability requirements. Integral to the RAM Roadmap was the use of a RAM analytical/simulation tool which was used to estimate the availability of the system when deployed based on current design configuration and the maturation level of the system.« less

Review of musculoskeletal injuries and prevention in the endoscopy practitioner.

PubMed

Harvin, Glenn

2014-08-01

Practitioners of endoscopy often experience musculoskeletal pain and injury (most often in the back, neck, shoulders, hands, wrists, and thumbs) that are associated with the minute and repetitive strain that is placed on these areas during endoscopic procedures. This review of the current documentation of endoscopy-related pain and injuries among practitioners finds that such problems are widespread and specific in kind as well as strongly correlated with high procedure volume and procedure duration. Research on the nature and impact of cumulative trauma and overuse syndromes in other professions such as dentistry, pianists, production labor, and athletics is brought to bear on the work of the endoscopist. A more thorough understanding of the nature and prevalence of work-related pain and injury sustained by endoscopists should inform further development of ergonomic practices and equipment design. This article reviews current recommendations for ergonomic design in the endoscopy procedure space and finds that reported compliance with those recommendations is quite low. Strategies for the management of the risk of musculoskeletal injuries related to the practice of endoscopy include compliance with currently recommended ergonomic practices, education of trainees in ergonomic technique when practicing endoscopy, and research toward the modification and development of more ergonomic endoscopes and procedure spaces.

Biomarkers for immune-related toxicities of checkpoint inhibitors: current progress and the road ahead.

PubMed

Patil, Pradnya D; Burotto, Mauricio; Velcheti, Vamsidhar

2018-03-01

Immune checkpoint pathways are key immune regulatory pathways that play a physiologic role in maintaining immune-homeostasis and are often co-opted by cancer cells to evade the host immune system. Recent developments in cancer immunotherapy, mainly drugs blocking the immune checkpoint pathways, have revolutionized the treatment paradigm for many solid tumors. A wide spectrum of immune-related adverse events (irAEs) have been described with the use of these agents which necessitate treatment with immunosuppression, lead to disruption of therapy and can on occasion be life-threatening. There are currently no clinically validated biomarkers to predict the risk of irAEs. Areas covered: In this review, the authors describe the current progress in identifying biomarkers for irAEs and potential future directions. Literature search was conducted using PubMed-MEDLINE, Embase and Scopus. In addition, abstracts from major conference proceedings were reviewed for relevant content. Expert commentary: The discovery of biomarkers for irAEs is currently in its infancy, however there are a lot of promising candidate biomarkers that are currently being investigated. Biomarkers that can identify patients at a higher risk of developing irAEs or lead to early detection of autoimmune toxicities are crucial to optimize patient selection for immune-oncology agents and to minimize toxicity with their use.

Current development in microfluidic immunosensing chip.

PubMed

Henares, Terence G; Mizutani, Fumio; Hisamoto, Hideaki

2008-03-17

This review accounts for the current development in microfluidic immunosensing chips. The basic knowledge of immunoassay in relation to its microfluidic material substrate, fluid handling and detection mode are briefly discussed. Here, we mainly focused on the surface modification, antibody immobilization, detection, signal enhancement and multiple analyte sensing. Some of the clinically important currently implemented on the microfluidic immunoassay chips are C-reactive protein (CRP), prostate specific antigen (PSA), ferritin, vascular endothelial growth factor (VEGF), myoglobin (Myo), cardiac troponin T (cTnT), cardiac troponin I (cTnI), and creatine kinase-cardiac muscle isoform (CK-MB). The emerging microfludic immunosensor technology may be a promising prospect that can propel the improvement of clinical and medical diagnosis.

Career Adaptability as a Strategic Competence for Career Development: An Exploratory Study of Its Key Predictors

ERIC Educational Resources Information Center

Bocciardi, Federica; Caputo, Andrea; Fregonese, Chiara; Langher, Viviana; Sartori, Riccardo

2017-01-01

Purpose: In the current labour market, the competence to adapt is becoming significantly relevant for career development and career success. The construct of career adaptability, i.e. the capability to adapt to changing career-related circumstances and predict advancement in career development, seems to provide a fruitful scientific base for…

Adjunct Experiences with and Perceptions of Professional Development at a Texas Community College

ERIC Educational Resources Information Center

Miles, R. Mark

2017-01-01

Universities and colleges have developed an over-reliance on adjunct faculty, and as a result, researchers have begun to study adjunct faculty satisfaction as it relates to their working conditions. Current research indicates that professional development is a source that can contribute to satisfaction at work (Hoyt, 2012). However, the research…

The Effect of Strengths Awareness and Development on the Self-Efficacy of Teachers

ERIC Educational Resources Information Center

Griffin, Lauren Elyse

2016-01-01

Increasing teacher efficacy poses challenges to educational leaders, highlighting the need for a study of the awareness and development of strengths related to teacher efficacy. The purpose of the current study was to examine the effect of the awareness and development of strengths on teachers' perceived self-efficacy, as well as to determine if…

The New Agent: A Qualitative Study to Strategically Adapt New Agent Professional Development

ERIC Educational Resources Information Center

Baker, Lauri M.; Hadley, Gregg

2014-01-01

The qualitative study reported here assessed the needs of agents related to new agent professional development to improve the current model. Agents who participated in new agent professional development within the last 5 years were selected to participate in focus groups to determine concerns and continued needs. Agents enjoyed networking and…

Dance Talent Development across the Lifespan: A Review of Current Research

ERIC Educational Resources Information Center

Chua, Joey

2014-01-01

The aim of this study is to compile and synthesize empirically based articles published between 2000 and 2012 about the critical issues of developing dance talents across the lifespan of children, adolescents and adults. The present article updates and extends a review article related to the identification and development in dance written by…

Resource Sharing in West Africa: Some Implications for the Development of National Information Policies.

ERIC Educational Resources Information Center

Sheriff, G. M.

This paper briefly examines the current state of library cooperation in the West African countries, in relation to the implementation of national information policies in these countries. Library cooperation within the framework of a national information policy in developing countries is considered as a primary need rather than the development of…

Child Psychopathy: Theories, Measurement, and Relations with the Development and Persistence of Conduct Problems

ERIC Educational Resources Information Center

Kotler, Julie S.; McMahon, Robert J.

2005-01-01

To develop more accurate explanatory and predictive models of child and adolescent conduct problems, interest has grown in examining psychopathic traits in youth. The presence or absence of these traits may help to identify unique etiological pathways in the development of antisocial behavior. The current review provides a detailed summary and…

DEVELOPING RELATIVE POTENCY FACTORS FOR PESTICIDE MIXTURES: BIOSTATISTICAL ANALYSES OF JOINT DOSE-RESPONSE

EPA Science Inventory

The 1996 Food Quality Protection Act (FQPA) and the 1996 Safe Drinking Water Act Amendments (SDWAA) reaffirm previous Acts that mandate the EPA to evaluate risks posed by environmental chemical mixtures. The current report develops biological concepts and statistical procedures f...

Fossil Fuels.

ERIC Educational Resources Information Center

Crank, Ron

This instructional unit is one of 10 developed by students on various energy-related areas that deals specifically with fossil fuels. Some topics covered are historic facts, development of fuels, history of oil production, current and future trends of the oil industry, refining fossil fuels, and environmental problems. Material in each unit may…

Exploring the ring current of carbon nanotubes by first-principles calculations.

PubMed

Ren, Pengju; Zheng, Anmin; Xiao, Jianping; Pan, Xiulian; Bao, Xinhe

2015-02-01

Ring current is a fundamental concept to understand the nuclear magnetic resonance (NMR) properties and aromaticity for conjugated systems, such as carbon nanotubes (CNTs). Employing the recently developed gauge including projector augmented wave (GIPAW) method, we studied the ring currents of CNTs systematically and visualized their distribution. The ring current patterns are determined by the semiconducting or metallic properties of CNTs. The discrepancy is mainly caused by the axial component of external magnetic fields, whereas the radial component induced ring currents are almost independent of the electronic structures of CNTs, where the intensities of the ring currents are linearly related to the diameters of the CNTs. Although the ring currents induced by the radial component are more intense than those by the axial component, only the latter determines the overall NMR responses and aromaticity of the CNTs as well. Furthermore, the semiconducting CNTs are more aromatic than their metallic counterparts due to the existence of delocalized ring currents on the semiconducting CNTs. These fundamental features are of vital importance for the development of CNT-based nanoelectronics and applications in magnetic fields.

Exploring the ring current of carbon nanotubes by first-principles calculations

PubMed Central

Ren, Pengju; Zheng, Anmin; Xiao, Jianping; Pan, Xiulian

2015-01-01

Ring current is a fundamental concept to understand the nuclear magnetic resonance (NMR) properties and aromaticity for conjugated systems, such as carbon nanotubes (CNTs). Employing the recently developed gauge including projector augmented wave (GIPAW) method, we studied the ring currents of CNTs systematically and visualized their distribution. The ring current patterns are determined by the semiconducting or metallic properties of CNTs. The discrepancy is mainly caused by the axial component of external magnetic fields, whereas the radial component induced ring currents are almost independent of the electronic structures of CNTs, where the intensities of the ring currents are linearly related to the diameters of the CNTs. Although the ring currents induced by the radial component are more intense than those by the axial component, only the latter determines the overall NMR responses and aromaticity of the CNTs as well. Furthermore, the semiconducting CNTs are more aromatic than their metallic counterparts due to the existence of delocalized ring currents on the semiconducting CNTs. These fundamental features are of vital importance for the development of CNT-based nanoelectronics and applications in magnetic fields. PMID:29560175

The Development of Expert Face Processing: Are Infants Sensitive to Normal Differences in Second-Order Relational Information?

ERIC Educational Resources Information Center

Hayden, Angela; Bhatt, Ramesh S.; Reed, Andrea; Corbly, Christine R.; Joseph, Jane E.

2007-01-01

Sensitivity to second-order relational information (i.e., spatial relations among features such as the distance between eyes) is a vital part of achieving expertise with face processing. Prior research is unclear on whether infants are sensitive to second-order differences seen in typical human populations. In the current experiments, we examined…

Insects as test systems for assessing the potential role of microgravity in biological development and evolution

NASA Astrophysics Data System (ADS)

Vernós, I.; Carratalá, M.; González-Jurado, J.; Valverde, J. R.; Calleja, M.; Domingo, A.; Vinós, J.; Cervera, M.; Marco, R.

Gravity and radiation are undoubtedly the two major environmental factors altered in space. Gravity is a weak force, which creates a permanent potential field acting on the mass of biological systems and their cellular components, strongly reduced in space flights. Developmental systems, particularly at very early stages, provide the larger cellular compartments known, where the effects of alterations in the size of the gravity vector on living organisms can be more effectively tested. The insects, one of the more highly evolved classes of animals in which early development occurs in a syncytial embryo, are systems particularly well suited to test these effects and the specific developmental mechanisms affected. Furthermore, they share some basic features such as small size, short life cycles, relatively high radio-resistance, etc. and show a diversity of developmental strategies and tempos advantageous in experiments of this type in space. Drosophila melanogaster, the current biological paradigm to study development, with so much genetic and evolutionary background available, is clearly the reference organism for these studies. The current evidence on the effects of the physical parameters altered in space flights on insect development indicate a surprising correlation between effects seen on the fast developing and relatively small Drosophila embryo and the more slowly developing and large Carausius morosus system. In relation to the issue of the importance of developmental and environmental constraints in biological evolution, still the missing link in current evolutionary thinking, insects and space facilities for long-term experiments could provide useful experimental settings where to critically assess how development and evolution may be interconnected. Finally, it has to be pointed out that since there are experimental data indicating a possible synergism between microgravity and space radiation, possible effects of space radiation should be taken into account in the planning and evaluation of experiments designed to test the potential role of microgravity on biological development and evolution.

Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

PubMed Central

Nau, Gerard J.; Ross, Ted M.; Evans, Thomas G.; Chakraborty, Krishnendu; Empey, Kerry M.; Flynn, JoAnne L.

2014-01-01

Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The “Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy” session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials. PMID:25148426

Examining temporal alterations in Social Anxiety Disorder and Posttraumatic Stress Disorder: The relation between autobiographical memory, future goals, and current self-views.

PubMed

Krans, Julie; Peeters, Manon; Näring, Gérard; Brown, Adam D; de Bree, June; van Minnen, Agnes

2017-12-01

The self is a multi-faceted and temporally dynamic construct reflecting representations and beliefs about identity in the past, present, and future. Clinical studies have shown that individuals with Posttraumatic Stress Disorder (PTSD) and Social Anxiety Disorder (SAD) exhibit alterations in self-related processing but these studies have focused primarily on memory. Few studies in PTSD and SAD have examined self-related processing for the present and future, and no studies have directly compared these processes across these two disorders. Individuals diagnosed with PTSD (n=21), SAD (n=21), and healthy controls (n=21) completed cognitive tasks related to the past, present, and future. Disorder congruent temporal alterations were found across both disorders. Further, regression analyses revealed that trauma-related memories were significantly predicted by future goals related to the trauma, whereas social anxiety-related recall was predicted by current socially anxious self-views. Thus, although self-related processing may be common in PTSD and SAD, those aspects of the self most strongly associated with disorder-congruent recall differ by disorder. Self-alterations may be modifiable and developing a better understanding of past, present, and future self-processing might aid in the development of interventions that target these process. Copyright © 2017 Elsevier Ltd. All rights reserved.

Advanced Thermal Control Technologies for "CEV" (New Name: ORION)

NASA Technical Reports Server (NTRS)

Golliher, Eric; Westheimer, David; Ewert, Michael; Hasan, Mojib; Anderson, Molly; Tuan, George; Beach, Duane

2007-01-01

NASA is currently investigating several technology options for advanced human spaceflight. This presentation covers some recent developments that relate to NASA's Orion spacecraft and future Lunar missions.

The evolution of the high-speed civil transport

NASA Technical Reports Server (NTRS)

Spearman, M. Leroy

1994-01-01

Current research directed toward the technology requirements for a high-speed civil transport (HSCT) airplane is an outgrowth of many years of activity related to air transportation. The purpose was to review some of the events that provided the background upon which current research programs are built. The review will include the subsonic era of transport aircraft and some events of the supersonic era that are related to the development of commercial supersonic transport aircraft. These events include the early NASA in-house studies and industry evaluations, the U.S. Supersonic Transport (SST) Program, the follow-on NASA supersonic cruise research programs, and the issuance of the National Aeronautical Research and Development (R&D) goals. Observations are made concerning some of the factors, both technical and nontechnical, that have had an impact on HSCT studies.

The GHSG Approach to Treating Hodgkin's Lymphoma.

PubMed

Bröckelmann, Paul J; Engert, Andreas

2015-09-01

Hodgkin's lymphoma (HL) is a relatively rare disease accounting for 15 % of all lymphoma. This disease has developed from an incurable disease to the adult malignancy with the most favorable prognosis. With current therapeutic approaches consisting of polychemo- and small-field radiotherapy, up to 80 % of all patients can be cured long term. In refractory or relapsed HL, intensified treatment including high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) is associated with progression-free survival (PFS) of 50 %. Evaluation of novel drugs in multiple relapsed or refractory cases, better treatment options for elderly patients and reducing treatment-related side effects are the main focus of current research. Recent clinical developments and future approaches in the treatment of HL will be discussed in this review.

Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development

PubMed Central

Agarwal, Aniruddha; Rhoades, William R; Hanout, Mostafa; Soliman, Mohamed Kamel; Sarwar, Salman; Sadiq, Mohammad Ali; Sepah, Yasir Jamal; Do, Diana V; Nguyen, Quan Dong

2015-01-01

Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described. PMID:26089632

Children adopted from China: a prospective study of their growth and development.

PubMed

Cohen, Nancy J; Lojkasek, Mirek; Zadeh, Zohreh Yaghoub; Pugliese, Mirella; Kiefer, Heidi

2008-04-01

China has become a lead country for international adoption because of the relatively young age of the children and reported positive conditions of the orphanages. This study examined the process and outcome of growth and development of children adopted from China over their first two years with their adoptive families. Seventy infant girls adopted from China at 8 to 21 months of age (Mean age = 13 months) were examined on arrival in Canada and 6, 12, and 24 months later. Comparisons were made with non-adopted Canadian girls of similar age and from a similar family background as adoptive parents on indices of growth and standardized measures of mental, psychomotor, and language development. At arrival, children adopted from China were smaller physically and exhibited developmental delays compared to current peers. Children adopted from China were functioning in the average range on physical and developmental measures within the first 6 months following adoption. However, they were not performing as well as current peers until the end of their second year after adoption. Even then, there was developmental variation in relation to comparison children and continuation of relatively smaller size with respect to height, weight, and head circumference. Physical measurement was related to outcomes at various points on all developmental measures. Deprivation in experience in the first year of life has more long-lasting effects on physical growth than on mental development. The variable most consistently related to development was height-to-age ratio. As a measure of nutritional status, the findings reinforce the critical importance of early nutrition.

Constraint-based integration of planning and scheduling for space-based observatory management

NASA Technical Reports Server (NTRS)

Muscettola, Nicola; Smith, Steven F.

1994-01-01

Progress toward the development of effective, practical solutions to space-based observatory scheduling problems within the HSTS scheduling framework is reported. HSTS was developed and originally applied in the context of the Hubble Space Telescope (HST) short-term observation scheduling problem. The work was motivated by the limitations of the current solution and, more generally, by the insufficiency of classical planning and scheduling approaches in this problem context. HSTS has subsequently been used to develop improved heuristic solution techniques in related scheduling domains and is currently being applied to develop a scheduling tool for the upcoming Submillimeter Wave Astronomy Satellite (SWAS) mission. The salient architectural characteristics of HSTS and their relationship to previous scheduling and AI planning research are summarized. Then, some key problem decomposition techniques underlying the integrated planning and scheduling approach to the HST problem are described; research results indicate that these techniques provide leverage in solving space-based observatory scheduling problems. Finally, more recently developed constraint-posting scheduling procedures and the current SWAS application focus are summarized.

Workshop on Countering Space Adaptation with Exercise: Current Issues

NASA Technical Reports Server (NTRS)

Harris, Bernard A. (Editor); Siconolfi, Steven F. (Editor)

1994-01-01

The proceedings represent an update to the problems associated with living and working in space and the possible impact exercise would have on helping reduce risk. The meeting provided a forum for discussions and debates on contemporary issues in exercise science and medicine as they relate to manned space flight with outside investigators. This meeting also afforded an opportunity to introduce the current status of the Exercise Countermeasures Project (ECP) science investigations and inflight hardware and software development. In addition, techniques for physiological monitoring and the development of various microgravity countermeasures were discussed.

Investigating gender violence in Jamaica.

PubMed

Spiring, Fred

2014-01-01

As Jamaica moves through implementation of their National Policy on Gender Equality and develops harassment legislation, this article attempts to investigate current levels and trends of gender-based violence in Jamaica. All analyses make use of existing data and data formats in developing performance indicators that illustrate the current state of gender violence in Jamaica. The analyses provide a baseline for the future assessment and comparison with internationally accepted gender-based violence indicators. All source data has been included to facilitate comparisons and discussions regarding related levels and trends of violence as well as addressing performance indicator effectiveness.

International programs related to the transmutation of transuranics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newman, C.

1991-04-01

This report is an account of current programs outside the U.S. relating to the transmutation of transuranics. This work was performed under contract to EPRI. The investigation was based on literature surveys, personal discussions, and visits to European research establishments that are currently active in the area. Research in actinide (uranium plus transuranics) partitioning and transmutation (P-T) is actively promoted in Japan, where the largest program in research on P-T is currently underway; however, following years of relative inactivity, the concept is being revisited elsewhere. Additionally, a significant amount of research in reprocessing and advanced reactors has produced results withmore » interesting possibilities for P-T. Foreign research activities relevant to actinide burning is presented in two sections: foreign national programs, and international programs and working groups. In order to provide the reader with an ability to assess the motivators for or against development of P-T, background on political and institutional trends relating to nuclear waste management is also provided. 38 refs., 17 figs.« less

Current phase relation from graphs and diagrams and application to thick ferromagnetic Josephson junctions

NASA Astrophysics Data System (ADS)

Margaris, I.; Paltoglou, V.; Flytzanis, N.

2018-05-01

In this work we present a method of representing terms in the current-phase-relation of a ballistic Josephson junction by combinations of diagrams, used in previous work to represent an equivalent of the matching condition determinant of the junction. This is accomplished by the expansion of the logarithm of this determinant in Taylor series and keeping track of surviving terms, i.e. terms that do not annihilate each other. The types of the surviving terms are represented by connected graphs, whose points represent diagrammatic terms of the determinant expansion. Then the theory is applied to obtain approximations of the current-phase relation of relatively thick ballistic ferromagnetic Josephson junctions with non-collinear magnetizations. This demonstrates the versatility of the method in developing approximations schemes and providing physical insight into the nature of contributions to the supercurrent from the available particle excitations in the junction. We also discuss the strong second harmonic contribution to the supercurrent in junctions with three mutually orthogonal magnetization vectors and a weak intermediate ferromagnet.

Extensive Reading in EFL Classroom at Secondary Schools in Bangladesh: Current Practices and Future Possibilities

ERIC Educational Resources Information Center

Haider, Md. Zulfeqar; Akhter, Elina

2012-01-01

Extensive reading is being practiced in many EFL and ESL classrooms as an effective means for developing learners' reading as well as other related skills. This paper is based on a small-scale study that explores the current practices and future possibilities of using extensive reading in the EFL classrooms at the junior secondary schools in…

Carnivals, the Carnivalesque, "The Magic Puddin'," and David Almond's "Wild Girl, Wild Boy": Toward a Theorizing of Children's Plays.

ERIC Educational Resources Information Center

Johnston, Rosemary Ross

2003-01-01

Seeks to extend current children's literature criticism into children's plays and children's theatre. Uses Norman Lindsay's "The Magic Pudding" as a prose introduction to an idea of a theatrical carnivalesque. Develops a theory of plays-as-the-performance-of-texts, relating this to the current debate on performance and performativity.…

Characteristic parameters of superconductor-coolant interaction including high Tc current density limits

NASA Technical Reports Server (NTRS)

Frederking, T. H. K.

1989-01-01

In the area of basic mechanisms of helium heat transfer and related influence on super-conducting magnet stability, thermal boundary conditions are important constraints. Characteristic lengths are considered along with other parameters of the superconducting composite-coolant system. Based on helium temperature range developments, limiting critical current densities are assessed at low fields for high transition temperature superconductors.

Selection, Placement and Instatement of School Managers in Turkey: Evaluation of the Current Situation

ERIC Educational Resources Information Center

Memisoglu, Salih Pasa

2015-01-01

The aim of this study is to evaluate the new regulations and current practices in terms of how they apply--to the selection, training and instatement of school administrators in Turkey. The successful implementation of Turkish National Development Plans is closely related to the knowledge and skills of managers working at various levels in every…

Dimensional Structure of the Autism Phenotype: Relations between Early Development and Current Presentation

ERIC Educational Resources Information Center

Kamp-Becker, Inge; Ghahreman, Mardjan; Smidt, Judith; Remschmidt, Helmut

2009-01-01

The dimensional structure of higher functioning autism phenotype was investigated by factor analysis. The goal of this study was to identify the degree to which early symptoms of autism (measured using the ADI-R) could be predictive of the current symptoms of autism as identified using the ADOS, the adaptive behavior scales, IQ scores and theory…

Application of Biomarkers in the Development of Drugs Intended for the Treatment of Osteoarthritis

PubMed Central

Kraus, Virginia Byers; Burnett, Bruce; Coindreau, Javier; Cottrell, Susan; Eyre, David; Gendreau, Michael; Gardiner, Jennifer; Garnero, Patrick; Hardin, John; Henrotin, Yves; Heinegård, Dick; Ko, Amy; Lohmander, Stefan; Matthews, Gloria; Menetski, Joseph; Moskowitz, Roland; Persiani, Stefano; Poole, Robin; Rousseau, Jean Charles; Todman, Martin

2013-01-01

Objective Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA drug discovery and development programs. The goal of this document is to provide a summary and guide to the application of in vitro (biochemical and other soluble) biomarkers in the development of drugs for OA and to outline and stimulate a research agenda that will further this goal. Methods The Biomarkers Working Group representing experts in the field of OA biomarker research from both academia and industry developed this consensus document between 2007–2009 at the behest of the Osteoarthritis Research Society International (OARSI FDA initiative). Results This document summarizes definitions and classification systems for biomarkers, the current outcome measures used in OA clinical trials, applications and potential utility of biomarkers for development of OA therapeutics, the current state of qualification of OA-related biomarkers, pathways for biomarker qualification, critical needs to advance the use of biomarkers for drug development, recommendations regarding practices and clinical trials, and a research agenda to advance the science of OA-related biomarkers. Conclusions Although many OA-related biomarkers are currently available they exist in various states of qualification and validation. The biomarkers that are likely to have the earliest beneficial impact on clinical trials fall into two general categories, those that will allow targeting of subjects most likely to either respond and/or progress (prognostic value) within a reasonable and manageable time frame for a clinical study (for instance within one to two years for an OA trial), and those that provide early feedback for preclinical decision-making and for trial organizers that a drug is having the desired biochemical effect. As in vitro biomarkers are increasingly investigated in the context of specific drug treatments, advances in the field can be expected that will lead to rapid expansion of the list of available biomarkers with increasing understanding of the molecular processes that they represent. PMID:21396468

Air Quality Criteria for Particulate Matter.

ERIC Educational Resources Information Center

National Air Pollution Control Administration (DHEW), Washington, DC.

To assist states in developing air quality standards, this book offers a review of literature related to atmospheric particulates and the development of criteria for air quality. It not only summarizes the current scientific knowledge of particulate air pollution, but points up the major deficiencies in that knowledge and the need for further…

Development of New Energy Cane Culitvars

USDA-ARS?s Scientific Manuscript database

Research into alternative energy sources has been on the rise since the 1970s. Novel sources of carbon-neutral energy are currently in high demand, but can pose different challenges in their development. Energy cane is a relatively new generation crop being bred as a source for biofuel feedstock and...

78 FR 27189 - Proposed Information Collection; Comment Request; Developing Social Wellbeing Indicators for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... Fisheries social scientists must collect a broad range of social, cultural, and economic information that is currently unavailable. This research is designed to improve social science data related to the human... Collection; Comment Request; Developing Social Wellbeing Indicators for Marine Management AGENCY: National...

Curriculum Development and Discursive Practices: Building a Training Culture around Dual Diagnosis.

ERIC Educational Resources Information Center

Goldsmith, Steve

Dual diagnosis of comorbid substance abuse and mental disorder is currently presenting great difficulties across Australia's health and community service sectors. Historically, mental health professionals have received relatively little formal education or training in substance abuse issues. A new curriculum on dual diagnosis was developed and…

Issues in Work-Related Education. EAE605 Human Resource Development.

ERIC Educational Resources Information Center

Deakin Univ., Victoria (Australia).

This publication is part of the study materials for the one-semester distance education unit, Human Resource Development, in the Open Campus Program at Deakin University (Australia). It contains three essays that explore the approaches to learning currently modeled within industry. "Training for Women" (Kathy MacDermott) presents the…

Workshop on Instructional Features and Instructor/Operator Station Design for Training Systems.

ERIC Educational Resources Information Center

Ricard, G. L., Ed.; And Others

These 19 papers review current research and development work related to the operation of the instructor's station of training systems, with emphasis on developing functional station specifications applicable to a variety of simulation-based training situations. Topics include (1) instructional features; (2) instructor/operator station research and…

Culture and Development: From Romantic Relativism to Reality.

ERIC Educational Resources Information Center

O'Toole, Tom

Using case studies of French-speaking West Africa and Southern Appalachia, this paper examines the role of traditional culture in developing regions by challenging current theories on that subject. The capitalistic and Marxist approaches that dominated well into the 1960s maintained that elimination of traditional social relations and values was…

Peer Observation--A Case for Doing It Online

ERIC Educational Resources Information Center

Bennett, Shirley; Barp, Donatella

2008-01-01

Peer observation is increasingly a feature of higher education (HE) practice. We argue that the principal drivers of quality assurance and professional development apply online as offline, given the growing importance of e-learning and related teacher development needs. Currently, discussion is largely restricted to traditional classroom-based…

Culture and Self in Career Development: Working with American Indians

ERIC Educational Resources Information Center

Juntunen, Cindy L.; Cline, Kara

2010-01-01

The career development concerns of American Indians continue to receive limited attention in the vocational or career literature. To address this deficit, the current article will apply the cultural formulation approach to career counseling with American Indians. This article presents information on factors related to cultural and self-identity…

Reading Trajectories of Children with Language Difficulties from Preschool through Fifth Grade

ERIC Educational Resources Information Center

Skibbe, Lori E.; Grimm, Kevin J.; Stanton-Chapman, Tina L.; Justice, Laura M.; Pence, Khara L.; Bowles, Ryan P.

2008-01-01

Purpose: The current work examined which theory of reading development, the "cumulative reading trajectory or the compensatory trajectory of development," most accurately represents the reading trajectories of children with language difficulties (LD) relative to their peers with typical language (TL) skills. Specifically, initial levels of reading…

75 FR 4615 - Agency Information Collection Activities: Notice of Request for Extension of Currently Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-28

... educational programs relating to the history and construction techniques of historic covered bridges... cultural tourism or enhances the history/ economic development of the community; and other benefits upon... preservation efforts; how it enhances cultural tourism or enhances the history/ economic development of the...

Family-Peer Relationships: Modes of Linkage.

ERIC Educational Resources Information Center

Parke, Ross D., Ed.; Ladd, Gary W., Ed.

This book surveys new developments in research on family-peer relations and discusses the impact of these developments on current knowledge and future research. The book's 14 chapters are: (1) "Themes and Theories: Perspectives on Processes in Family-Peer Relationships" (G. Ladd); (2) "Family and Peer Relationships in Historical Perspective" (P.…

Development of the Social Efficacy and Social Outcome Expectations Scale

ERIC Educational Resources Information Center

Wright, Stephen L.; Wright, Dorothy A.; Jenkins-Guarnieri, Michael A.

2013-01-01

The current study developed an 18-item scale measuring individuals' social expectations in relationships related to their efficacy expectations (Subscale 1) and outcome expectations (Subscale 2) based on Bandura's self-efficacy theory. Results from exploratory and confirmatory factor analyses, using an undergraduate sample ("N" = 486),…

To and From the Field: Communications and Agriculture.

ERIC Educational Resources Information Center

Development Communication Report, 1978

1978-01-01

Information on current research and projects, as well as general suggestions and conceptual material, is presented in 11 articles related to communication in rural areas of developing nations. These articles deal with (1) how information flows to small Nepalese farms; (2) an overview of communication in agricultural development projects, with…

Exploring the Discourses of Our Own Practice: A Case Study.

ERIC Educational Resources Information Center

Sanguinetti, Jill

1994-01-01

Reflects on ideas of feminism and critical literacy and their significance in relation to the current policy environment. Topics explored include the dilemmas of personal development; issues of culture, power, and coercion; shifting the focus to teaching; personal and pedagogical influences; pedagogical praxis; and developing a collective…

24 CFR 1710.215 - Subdivision characteristics and climate.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Subdivision characteristics and climate. 1710.215 Section 1710.215 Housing and Urban Development Regulations Relating to Housing and Urban... Requirements § 1710.215 Subdivision characteristics and climate. (a) Submit two copies of a current geological...

24 CFR 1710.215 - Subdivision characteristics and climate.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Subdivision characteristics and climate. 1710.215 Section 1710.215 Housing and Urban Development Regulations Relating to Housing and Urban... Requirements § 1710.215 Subdivision characteristics and climate. (a) Submit two copies of a current geological...

24 CFR 1710.215 - Subdivision characteristics and climate.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Subdivision characteristics and climate. 1710.215 Section 1710.215 Housing and Urban Development Regulations Relating to Housing and Urban... Requirements § 1710.215 Subdivision characteristics and climate. (a) Submit two copies of a current geological...

24 CFR 1710.215 - Subdivision characteristics and climate.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Subdivision characteristics and climate. 1710.215 Section 1710.215 Housing and Urban Development Regulations Relating to Housing and Urban... Requirements § 1710.215 Subdivision characteristics and climate. (a) Submit two copies of a current geological...

24 CFR 1710.215 - Subdivision characteristics and climate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Subdivision characteristics and climate. 1710.215 Section 1710.215 Housing and Urban Development Regulations Relating to Housing and Urban... Requirements § 1710.215 Subdivision characteristics and climate. (a) Submit two copies of a current geological...

Ethnic Identity and Career Development among First-Year College Students

ERIC Educational Resources Information Center

Duffy, Ryan D.; Klingaman, Elizabeth A.

2009-01-01

The current study explored the relation of ethnic identity achievement and career development progress among a sample of 2,432 first-year college students who completed the Career Decision Profile and Phinney's Multigroup Ethnic Identity Measure. Among students of color, correlational analyses revealed a series of statistically significant, but…

Personalized medicine and chronic obstructive pulmonary disease.

PubMed

Wouters, E F M; Wouters, B B R A F; Augustin, I M L; Franssen, F M E

2017-05-01

The current review summarizes ongoing developments in personalized medicine and precision medicine in chronic obstructive pulmonary disease (COPD). Our current approach is far away of personalized management algorithms as current recommendations for COPD are largely based on a reductionist disease description, operationally defined by results of spirometry. Besides precision medicine developments, a personalized medicine approach in COPD is described based on a holistic approach of the patient and considering illness as the consequence of dynamic interactions within and between multiple interacting and self-adjusting systems. Pulmonary rehabilitation is described as a model of personalized medicine. Largely based on current understanding of inflammatory processes in COPD, targeted interventions in COPD are reviewed. Augmentation therapy for α-1-antitrypsine deficiency is described as model of precision medicine in COPD based in profound understanding of the related genetic endotype. Future developments of precision medicine in COPD require identification of relevant endotypes combined with proper identification of phenotypes involved in the complex and heterogeneous manifestations of COPD.

Current NASA Plans for Mars In Situ Resource Utilization

NASA Technical Reports Server (NTRS)

Sanders, Gerald

2018-01-01

The presentation is to provide relevant information to the NASA funded Center for the Utilization of Biological Engineering in Space (CUBES) Institute. The presentation cover the following: 1) What is In Situ Resource Utilization (ISRU), 2) What are the resources of interest at the Moon and Mars, 3) ISRU-related mission requirements and ISRU economics, 4) Challenges and Risk for ISRU, 5) Concept of Operation for Mars ISRU Systems, 6) Current State of the Art (SOA) in ISRU, and 7) Current ISRU development and mission status.

The Water-Energy-Food Nexus in a Rapidly Developing Resource Sector

NASA Astrophysics Data System (ADS)

Allen, D. M.; Kirste, D. M.

2014-12-01

Technological advances and access to global markets have changed the rate at which resource exploitation takes place. The environmental impact of the rapid development and distribution of resources such as minerals and hydrocarbons has led to a greater potential for significant stress on water resources both in terms of quality and quantity. How and where those impacts manifest is crucial to determining appropriate risk management strategies. North East British Columbia has an abundance of shale gas reserves that are anticipated to be exploited at a large scale in coming years, primarily for export as liquefied natural gas (LNG). However, there is growing concern that fracking and other activities related to shale gas development pose risks to water quality and quantity in the region. Water lies at the center of the water-energy-food nexus, with an accelerating water demand for fracking and industrial operations as well as for domestic, environmental and agricultural uses. Climate change is also anticipated to alter the hydrologic regime, posing added stress to the water resource. This case study examines the water-energy-food nexus in the context of a region that is impacted by a rapidly developing resource sector, encompassing water demand/supply, climate change, interaction between deep aquifers and shallow aquifers/surface waters, water quality concerns related to fracking, land use disturbance, and community impacts. Due to the rapid rate of development, there are significant knowledge gaps in our understanding of the water resource. Currently agencies are undertaking water resource assessments and establishing monitoring sites. This research aims to assess water security in North East British Columbia in a coordinated fashion through various partnerships. In addition to collecting baseline knowledge and data, the study will evaluate risk and resilience indicators in relation to water security. A risk assessment framework specific to the shale gas development context will be developed to evaluate the various components of risk spatially and temporally. Resilience is currently being assessed through a comprehensive examination of the current regulatory and policy regime.

Insects as test systems for assessing the potential role of microgravity in biological development and evolution.

PubMed

Vernós, I; Carratalá, M; González-Jurado, J; Valverde, J R; Calleja, M; Domingo, A; Vinós, J; Cervera, M; Marco, R

1989-01-01

Gravity and radiation are undoubtedly the two major environmental factors altered in space. Gravity is a weak force, which creates a permanent potential field acting on the mass of biological systems and their cellular components, strongly reduced in space flights. Developmental systems, particularly at very early stages, provide the larger cellular compartments known, where the effects of alterations in the size of the gravity vector on living organisms can be more effectively tested. The insects, one of the more highly evolved classes of animals in which early development occurs in a syncytial embryo, are systems particularly well suited to test these effects and the specific developmental mechanisms affected. Furthermore, they share some basic features such as small size, short life cycles, relatively high radio-resistance, etc. and show a diversity of developmental strategies and tempos advantageous in experiments of this type in space. Drosophila melanogaster, the current biological paradigm to study development, with so much genetic and evolutionary background available, is clearly the reference organism for these studies. The current evidence on the effects of the physical parameters altered in space flights on insect development indicate a surprising correlation between effects seen on the fast developing and relatively small Drosophila embryo and the more slowly developing and large Carausius morosus system. In relation to the issue of the importance of developmental and environmental constraints in biological evolution, still the missing link in current evolutionary thinking, insects and space facilities for long-term experiments could provide useful experimental settings where to critically assess how development and evolution may be interconnected. Finally, it has to be pointed out that since there are experimental data indicating a possible synergism between microgravity and space radiation, possible effects of space radiation should be taken into account in the planning and evaluation of experiments designed to test the potential role of microgravity on biological developmental and evolution.

A new approach to identify, classify and count drugrelated events

PubMed Central

Bürkle, Thomas; Müller, Fabian; Patapovas, Andrius; Sonst, Anja; Pfistermeister, Barbara; Plank-Kiegele, Bettina; Dormann, Harald; Maas, Renke

2013-01-01

Aims The incidence of clinical events related to medication errors and/or adverse drug reactions reported in the literature varies by a degree that cannot solely be explained by the clinical setting, the varying scrutiny of investigators or varying definitions of drug-related events. Our hypothesis was that the individual complexity of many clinical cases may pose relevant limitations for current definitions and algorithms used to identify, classify and count adverse drug-related events. Methods Based on clinical cases derived from an observational study we identified and classified common clinical problems that cannot be adequately characterized by the currently used definitions and algorithms. Results It appears that some key models currently used to describe the relation of medication errors (MEs), adverse drug reactions (ADRs) and adverse drug events (ADEs) can easily be misinterpreted or contain logical inconsistencies that limit their accurate use to all but the simplest clinical cases. A key limitation of current models is the inability to deal with complex interactions such as one drug causing two clinically distinct side effects or multiple drugs contributing to a single clinical event. Using a large set of clinical cases we developed a revised model of the interdependence between MEs, ADEs and ADRs and extended current event definitions when multiple medications cause multiple types of problems. We propose algorithms that may help to improve the identification, classification and counting of drug-related events. Conclusions The new model may help to overcome some of the limitations that complex clinical cases pose to current paper- or software-based drug therapy safety. PMID:24007453

The Development Officer in Higher Education: Toward an Understanding of the Role. ASHE-ERIC Higher Education Report No. 4.

ERIC Educational Resources Information Center

Worth, Michael J.; Asp, James W., II

Despite growth in the scope and importance of the college or university chief development officer's role, it remains relatively unexamined and the subject of differing perceptions. This report reviews the history and current status of the development function. Major authors on the subject are reviewed and placed into four "schools of…

Education, Culture, and Development: Co-ordinated Policies and Strategies. The Situation in Latin America and the Caribbean.

ERIC Educational Resources Information Center

Tedesco, J. C.

This document is a brief presentation of the relation among education, culture, and development in the Latin American and Caribbean countries that focuses on two major aspects: (1) the new development strategies currently being implemented in the region, and (2) the educational actions being undertaken as an answer to the new challenges posed by…

Language, Cognitive Flexibility, and Explicit False Belief Understanding: Longitudinal Analysis in Typical Development and Specific Language Impairment

ERIC Educational Resources Information Center

Farrant, Brad M.; Maybery, Murray T.; Fletcher, Janet

2012-01-01

The hypothesis that language plays a role in theory-of-mind (ToM) development is supported by a number of lines of evidence (e.g., H. Lohmann & M. Tomasello, 2003). The current study sought to further investigate the relations between maternal language input, memory for false sentential complements, cognitive flexibility, and the development of…

Energy Management Needs; A Project to Develop Solutions for Higher Education's Energy Problems in the 1980's.

ERIC Educational Resources Information Center

Coldren, Sharon L.; Mitchell, Cecilia

Current patterns of energy management within higher education institutions and energy-related information and services that are needed by senior administrators and others to develop and improve energy management and planning on campus were studied. The findings and recommendations will be used to help develop a new research and action program for…

Two Approaches to Estimating the Effect of Parenting on the Development of Executive Function in Early Childhood

ERIC Educational Resources Information Center

Blair, Clancy; Raver, C. Cybele; Berry, Daniel J.

2014-01-01

In the current article, we contrast 2 analytical approaches to estimate the relation of parenting to executive function development in a sample of 1,292 children assessed longitudinally between the ages of 36 and 60 months of age. Children were administered a newly developed and validated battery of 6 executive function tasks tapping inhibitory…

Master's Program Module "Environmental Issues--Decision Making Experience" as Precondition for Implementation of Education for Sustainable Development for Professional Training of Teachers

ERIC Educational Resources Information Center

Vinokurova, Natalia Fedorovna; Martilova, Natalia Viktorovna; Krivdina, Irina Yurievna; Badin, Mikhail Mikhailovich; Efimova, Olga Evgenyevna

2016-01-01

The article discusses current issues related to the implementation of the UNESCO roadmap implementing Global action programme on education for sustainable development. In the context of increasing the professional level of pedagogical workers is a priority area in the implementation of education for sustainable development. Therefore, we believe…

Qualitative Educational Research in Developing Countries: Current Perspectives. Reference Books in International Education, Volume 35. Garland Reference Library of Social Science, Volume 927.

ERIC Educational Resources Information Center

Crossley, Michael, Ed.; Vulliamy, Graham, Ed.

This book contains 11 essays that offer in-depth accounts of qualitative research in developing countries. Each chapter focuses upon a specific method and considers related theoretical and practical issues with reference to recent experiences in selected developing countries. Key issues addressed include: (1) the identification of appropriate…

Gravitational, erosional and sedimentary processes on volcanic ocean islands: Insights from the submarine morphology of Madeira archipelago

NASA Astrophysics Data System (ADS)

Quartau, R.; Ramalho, R.; Madeira, J.; Santos, R.; Rodrigues, A.; Roque, C.; Carrara, G.; da Silveira, A. B.

2017-12-01

In this work we report detailed observations of high-resolution bathymetric and backscatter mosaics of Madeira archipelago covering from the nearshore to the deep sea and relate them with the physical and geological setting of the islands. Our observations reveal that the submarine flanks of the archipelago are deeply dissected by large landslide scars and that most of them have involved subaerial material. Below the shelf break, landslide chutes develop downslope forming poorly defined depositional lobes. Around the islands, a large tributary system composed of gullies and channels develop where no significant rocky/ridge outcrops are present. This system is likely formed by turbidity currents that are triggered by hyperpicnal flows in Madeira or by storm-induced offshore sediment transport on Porto Santo and Desertas islands. At the lower part of the flanks (-3000 to -4300 m), where seafloor gradients decrease to 0.5º-3º, several scour and sediment wave fields are present, with the former normally occurring upslope of the latter. Sediment waves are often associated with the depositional lobes of the landslides but also occur offshore poorly-developed tributary systems. Sediment wave fields and scours are mostly absent on areas where the tributary systems are well developed and/or are dominated by rocky outcrops. Our study suggests that scours and sediment wave fields are probably formed by turbidity currents that suffer hydraulic jumps where the seafloor gradients are significantly reduced and where the currents become unconfined. The largest scours were found in areas without upslope channel systems and independently of wave fields, although also related to unconfined turbidity currents. Our observations show that tributary systems are better developed in prominent and rainy islands such as Madeira. On low and dry islands such as Porto Santo and Desertas, these are poorly developed and unconfined turbidite currents favour the development of scours and sediment wave fields. AcknowledgmentsThis work is funded by FCT-Fundação para a Ciência e a Tecnologia through the PLATMAR project (PTDC/GEO-GEO/0051/2014)

Evolution of Faculty-Principal Relations: A Look at What's Happening from the National Perspective. Educational Services Bulletin No. 53.

ERIC Educational Resources Information Center

Knezevich, S. J.

As well as looking at the historic development of faculty-principal relations, this paper focuses on current changes in and challenges to the principal's role. The paper contends that faculty-principal relations are central to what happens in education. It maintains that dramatic changes in schools demand new value orientations and styles of…

Employer Relations and Recruitment Services: An Essential Part of Postsecondary Career Services. Monograph Series

ERIC Educational Resources Information Center

Hoover, Myrna P.; Lenz, Janet G.; Garis, Jeff

2013-01-01

This monograph is intended for any career services provider seeking a guide for developing employer relations and recruitment services at a postsecondary institution. It serves to inform readers about the changing meaning of "placement" over the years and the role it currently plays in career services. The publication describes…

Precursors to the Development of Flexible Expertise: Metacognitive Self-Evaluations as Antecedences and Consequences in Adult Learning

ERIC Educational Resources Information Center

Birney, Damian P.; Beckmann, Jens F.; Wood, Robert E.

2012-01-01

The current study investigates a conceptualization of "flexible expertise" as it relates to adult learning within the context of management and leadership training. Three research domains and their relation to metacognitive outcomes are integrated: 1) individual differences in abilities, personality, and mindsets, 2) deliberate practice and…

Test-Retest Reliability of a Survey to Measure Transport-Related Physical Activity in Adults

ERIC Educational Resources Information Center

Badland, Hannah; Schofield, Grant

2006-01-01

The present research details test-retest reliability of a newly developed, telephone-administered TPA survey for adults. This instrument examines barriers, perceptions, and current travel behaviors to place of work/study and local convenience shops. Demonstrated test-retest reliability of the Active Friendly Environments-Transport-Related Physical…

Preschool Contexts and Teacher Interactions: Relations with School Readiness

ERIC Educational Resources Information Center

Goble, Priscilla; Hanish, Laura D.; Martin, Carol Lynn; Eggum-Wilkens, Natalie D.; Foster, Stacie A.; Fabes, Richard A.

2016-01-01

The majority of early education programs promote children's learning through a mix of experiences in child- and teacher-managed contexts. The current study examined time spent in child- and teacher-managed contexts and the nature of children's experiences with teachers in these contexts as they relate to children's skill development. Participants…

Pediatricians' Knowledge, Training, and Experience in the Care of Children with Fetal Alcohol Syndrome

ERIC Educational Resources Information Center

Gahagan, Sheila; Sharpe, Tanya Telfair; Brimacombe, Michael; Fry-Johnson, Yvonne; Levine, Robert; Mengel, Mark; O'Connor, Mary; Paley, Blair; Adubato, Susan; Brenneman, George

2007-01-01

Objectives: Prenatal exposure to alcohol interferes with fetal development and is the leading preventable cause of birth defects and developmental disabilities. The purpose of this study was to identify current knowledge, diagnosis, prevention, and intervention practices related to fetal alcohol syndrome and related conditions by members of the…

Relations among Children's Use of Dialect and Literacy Skills: A Meta-Analysis

ERIC Educational Resources Information Center

Gatlin, Brandy; Wanzek, Jeanne

2015-01-01

Purpose: The current meta-analysis examines recent empirical research studies that have investigated relations among dialect use and the development and achievement of reading, spelling, and writing skills. Method: Studies published between 1998 and 2014 were selected if they: (a) included participants who were in Grades K-6 and were typically…

How the Study of Regulation Can Inform the Study of Coping

ERIC Educational Resources Information Center

Eisenberg, Nancy; Valiente, Carlos; Sulik, Michael J.

2009-01-01

It is advantageous to study regulation and coping and their development at multiple levels of expression and origin simultaneously. We discuss several topics of current interest in the emotion-related regulation literature that are relevant to coping, including conceptual issues related to definitions and types of coping, types of physiological…

If Maxwell Had Worked between Ampere and Faraday: An Historical Fable with a Pedagogical Moral.

ERIC Educational Resources Information Center

Jammer, Max; Stachel, John

1980-01-01

Describes a new pedagogical approach to electromagnetic theory, in which the displacement current and the Galilean relativity principle are introduced before discussion of the Faraday induction term. Rationale for the alternate order of introducing these concepts and laws is explained, relative to their historical development. (CS)

Current knowledge and trends in age-related macular degeneration: genetics, epidemiology, and prevention.

PubMed

Velez-Montoya, Raul; Oliver, Scott C N; Olson, Jeffrey L; Fine, Stuart L; Quiroz-Mercado, Hugo; Mandava, Naresh

2014-03-01

To address the most dynamic and current issues concerning human genetics, risk factors, pharmacoeconomics, and prevention regarding age-related macular degeneration. An online review of the database Pubmed and Ovid was performed, searching for the key words: age-related macular degeneration, AMD, pharmacoeconomics, risk factors, VEGF, prevention, genetics and their compound phrases. The search was limited to articles published since 1985 to date. All returned articles were carefully screened and their references were manually reviewed for additional relevant data. The webpage www.clinicaltrials.gov was also accessed in search of relevant research trials. A total of 366 articles were reviewed, including 64 additional articles extracted from the references and 25 webpages and online databases from different institutions. At the end, only 244 references were included in this review. Age-related macular degeneration is a complex multifactorial disease that has an uneven manifestation around the world but with one common denominator, it is increasing and spreading. The economic burden that this disease poses in developed nations will increase in the coming years. Effective preventive therapies need to be developed in the near future.

The fight against tobacco in developing countries.

PubMed

Mackay, J L

1994-02-01

The battle to reduce the tobacco epidemic is not being won; the epidemic is merely being transferred from rich to poor countries. Tobacco-related mortality will rise from the present annual global toll of 3 million to over 10 million by the year 2025. Currently, most of these deaths are in developed countries but 7 out of the 10 million deaths will occur in developing countries by 2025. Developing countries cannot afford this increase, either in terms of human health or in economic costs, such as medical and health care costs, costs of lost productivity, costs of fires or costs of the misuse of land used to grow tobacco. As many of the tobacco-related illnesses, such as lung cancer or emphysema, are incurable even with expensive technology, the key to tobacco control lies in prevention. The essential elements of a national tobacco control policy are the same for all countries throughout the world--the only differences lie in fine tuning to a country's current situation. While indigenous production and consumption of tobacco remain a problem, of particular concern is the penetration of developing countries by the transnational tobacco companies, with aggressive promotional campaigns and the use of political and commercial pressures to open up markets and to promote foreign cigarettes. This includes specific targeting of women, few of whom currently smoke in developing countries. Also, tobacco advertising revenue prevents the media from reporting on the hazards of tobacco, a particularly serious problem in developing countries where awareness of the harmfulness of tobacco is low.(ABSTRACT TRUNCATED AT 250 WORDS)

Bisphenol A

MedlinePlus

... there is still uncertainty about some links between human health effects and exposure to endocrine disruptors. Both the ... to understand exactly how current findings relate to human health and development, according to the U.S. Food and ...

Modeling Current Transfer from PV Modules Based on Meteorological Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hacke, Peter; Smith, Ryan; Kurtz, Sarah

2016-11-21

Current transferred from the active cell circuit to ground in modules undergoing potential-induced degradation (PID) stress is analyzed with respect to meteorological data. Duration and coulombs transferred as a function of whether the module is wet (from dew or rain) or the extent of uncondensed surface humidity are quantified based on meteorological indicators. With this, functions predicting the mode and rate of coulomb transfer are developed for use in estimating the relative PID stress associated with temperature, moisture, and system voltage in any climate. Current transfer in a framed crystalline silicon module is relatively high when there is no condensedmore » water on the module, whereas current transfer in a thin-film module held by edge clips is not, and displays a greater fraction of coulombs transferred when wet compared to the framed module in the natural environment.« less

Applications of nanotechnology in gastric cancer: detection and prevention by nutrition.

PubMed

Elingarami, Sauli; Liu, Ming; Fan, Jing; He, Nongyue

2014-01-01

New and emerging technologies, such as nanotechnology, have the potential to advance nutrition science by assisting in the discovery, development, and delivery of several intervention strategies to improve health and reduce the risk and complications of several diseases, including gastric cancer. This article reviews gastric cancer in relation to nutrition, discussing gastric carcinogenesis in-depth in relation to prevention of the disease by nutrition, as well as current detection approaches using nanotechnology. The current status of molecular nutritional biomarkers for gastric cancer is also discussed, as well as future strategies for the tailored management of gastric cancer.

Cystic Fibrosis Related Liver Disease—Another Black Box in Hepatology

PubMed Central

Staufer, Katharina; Halilbasic, Emina; Trauner, Michael; Kazemi-Shirazi, Lili

2014-01-01

Due to improved medical care, life expectancy in patients with cystic fibrosis (CF) has veritably improved over the last decades. Importantly, cystic fibrosis related liver disease (CFLD) has become one of the leading causes of morbidity and mortality in CF patients. However, CFLD might be largely underdiagnosed and diagnostic criteria need to be refined. The underlying pathomechanisms are largely unknown, and treatment strategies with proven efficacy are lacking. This review focuses on current invasive and non-invasive diagnostic standards, the current knowledge on the pathophysiology of CFLD, treatment strategies, and possible future developments. PMID:25093717

On Convergence Acceleration Techniques for Unstructured Meshes

NASA Technical Reports Server (NTRS)

Mavriplis, Dimitri J.

1998-01-01

A discussion of convergence acceleration techniques as they relate to computational fluid dynamics problems on unstructured meshes is given. Rather than providing a detailed description of particular methods, the various different building blocks of current solution techniques are discussed and examples of solution strategies using one or several of these ideas are given. Issues relating to unstructured grid CFD problems are given additional consideration, including suitability of algorithms to current hardware trends, memory and cpu tradeoffs, treatment of non-linearities, and the development of efficient strategies for handling anisotropy-induced stiffness. The outlook for future potential improvements is also discussed.

Development of a new signal processor for tetralateral position sensitive detector based on single-chip microcomputer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang Meizhen; Shi Longzhao; Wang Yuxing

2006-08-15

An inherently nonlinear relation between the output current of the tetralateral position sensitive detector (PSD) and the position of the incident light spot has been found theoretically. Based on single-chip microcomputer and the theoretical relation between output current and position, a new signal processor capable of correcting nonlinearity and reducing position measurement deviation of tetralateral PSD was developed. A tetralateral PSD (S1200, 13x13 mm{sup 2}, Hamamatsu Photonics K.K.) was measured with the new signal processor, a linear relation between the output position of the PSD, and the incident position of the light spot was obtained. In the 60% range ofmore » a 13x13 mm{sup 2} active area, the position nonlinearity (rms) was 0.15% and the position measurement deviation (rms) was {+-}20 {mu}m. Compared with traditional analog signal processor, the new signal processor is of better compatibility, lower cost, higher precision, and easier to be interfaced.« less

Development of a new signal processor for tetralateral position sensitive detector based on single-chip microcomputer

NASA Astrophysics Data System (ADS)

Huang, Mei-Zhen; Shi, Long-Zhao; Wang, Yu-Xing; Ni, Yi; Li, Zhen-Qing; Ding, Hai-Feng

2006-08-01

An inherently nonlinear relation between the output current of the tetralateral position sensitive detector (PSD) and the position of the incident light spot has been found theoretically. Based on single-chip microcomputer and the theoretical relation between output current and position, a new signal processor capable of correcting nonlinearity and reducing position measurement deviation of tetralateral PSD was developed. A tetralateral PSD (S1200, 13×13mm2, Hamamatsu Photonics K.K.) was measured with the new signal processor, a linear relation between the output position of the PSD, and the incident position of the light spot was obtained. In the 60% range of a 13×13mm2 active area, the position nonlinearity (rms) was 0.15% and the position measurement deviation (rms) was ±20μm. Compared with traditional analog signal processor, the new signal processor is of better compatibility, lower cost, higher precision, and easier to be interfaced.

Current situation and future usage of anticancer drug databases.

PubMed

Wang, Hongzhi; Yin, Yuanyuan; Wang, Peiqi; Xiong, Chenyu; Huang, Lingyu; Li, Sijia; Li, Xinyi; Fu, Leilei

2016-07-01

Cancer is a deadly disease with increasing incidence and mortality rates and affects the life quality of millions of people per year. The past 15 years have witnessed the rapid development of targeted therapy for cancer treatment, with numerous anticancer drugs, drug targets and related gene mutations been identified. The demand for better anticancer drugs and the advances in database technologies have propelled the development of databases related to anticancer drugs. These databases provide systematic collections of integrative information either directly on anticancer drugs or on a specific type of anticancer drugs with their own emphases on different aspects, such as drug-target interactions, the relationship between mutations in drug targets and drug resistance/sensitivity, drug-drug interactions, natural products with anticancer activity, anticancer peptides, synthetic lethality pairs and histone deacetylase inhibitors. We focus on a holistic view of the current situation and future usage of databases related to anticancer drugs and further discuss their strengths and weaknesses, in the hope of facilitating the discovery of new anticancer drugs with better clinical outcomes.

Intraformation positioning system

NASA Astrophysics Data System (ADS)

Sheldon, Stuart; Zadzora, Timothy

1996-05-01

The IntraFormation Positioning System is a networked relative navigation system currently being developed for rendezvous, join-up, and formation flight of Air Force helicopters and fixed wing aircraft in instrument meteorological conditions. The system is designed to be integrated into existing aircraft and will display relative positions of all aircraft within a formation, as well as the relative positions of other formations participating in coordinated missions. The system uses a Global Positioning System receiver integrated with the aircraft Inertial Navigation System to generate accurate aircraft position and velocity data. These data are transmitted over a data link to all participating aircraft and displayed as graphic symbols at the relative range and bearing to own aircraft on a situational awareness display format similar to a radar plan position indicator. Flight guidance computation is based on the difference between a desired formation slot position and current aircraft position relative to the formation lead aircraft. This information is presented on the flight director display allowing the pilot to null out position errors. The system is being developed for the Air Force Special Operations Command; however, it is applicable to all aircraft desiring improved formation situational awareness and formation flight coordination.

Current trends in nursing theories.

PubMed

Im, Eun-Ok; Chang, Sun Ju

2012-06-01

To explore current trends in nursing theories through an integrated literature review. The literature related to nursing theories during the past 10 years was searched through multiple databases and reviewed to determine themes reflecting current trends in nursing theories. The trends can be categorized into six themes: (a) foci on specifics; (b) coexistence of various types of theories; (c) close links to research; (d) international collaborative works; (e) integration to practice; and (f) selective evolution. We need to make our continuous efforts to link research and practice to theories, to identify specifics of our theories, to develop diverse types of theories, and to conduct international collaborative works. Our paper gives implications for future theoretical development in diverse clinical areas of nursing research and practice. © 2012 Sigma Theta Tau International.

In-service inspection methods for graphite-epoxy structures on commercial transport aircraft

NASA Technical Reports Server (NTRS)

Phelps, M. L.

1981-01-01

In-service inspection methods for graphite-epoxy composite structures on commercial transport aircraft are determined. Graphite/epoxy structures, service incurred defects, current inspection practices and concerns of the airline and manufacturers, and other related information were determind by survey. Based on this information, applicable inspection nondestructive inspection methods are evaluated and inspection techniques determined. Technology is developed primarily in eddy current inspection.

Effects of live crown on vertical patterns of wood density and growth in Douglas-fir.

Treesearch

Barbara L. Gartner; Eric M. North; G.R. Johnson; Ryan Singleton

2002-01-01

It would be valuable economically to know what are the biological triggers for formation of mature wood (currently of high value) and (or) what maintains production of juvenile wood (currently of low value), to develop silvicultural regimes that control the relative production of the two types of wood. Foresters commonly assume the bole of softwoods produces juvenile...

Summary of vulnerability related technologies based on machine learning

NASA Astrophysics Data System (ADS)

Zhao, Lei; Chen, Zhihao; Jia, Qiong

2018-04-01

As the scale of information system increases by an order of magnitude, the complexity of system software is getting higher. The vulnerability interaction from design, development and deployment to implementation stages greatly increases the risk of the entire information system being attacked successfully. Considering the limitations and lags of the existing mainstream security vulnerability detection techniques, this paper summarizes the development and current status of related technologies based on the machine learning methods applied to deal with massive and irregular data, and handling security vulnerabilities.

Scientific study in solar and plasma physics relative to rocket and balloon projects

NASA Technical Reports Server (NTRS)

Wu, S. T.

1993-01-01

The goals of this research are to provide scientific and technical capabilities in the areas of solar and plasma physics contained in research programs and instrumentation development relative to current rocket and balloon projects; to develop flight instrumentation design, flight hardware, and flight program objectives and participate in peer reviews as appropriate; and to participate in solar-terrestrial physics modeling studies and analysis of flight data and provide theoretical investigations as required by these studies.

Robotics research at Canadian Space Agency

NASA Technical Reports Server (NTRS)

Hui, Raymond

1994-01-01

In addition to major crown projects such as the Mobile Servicing System for Space Station, the Canadian Space Agency is also engaged in internal, industrial and academic research and development activities in robotics and other space-related areas of science and technology. These activities support current and future space projects, and lead to technology development which can be spun off to terrestrial applications, thus satisfying the Agency's objective of providing economic benefits to the public at large through its space-related work.

Revisions to the JDL data fusion model

NASA Astrophysics Data System (ADS)

Steinberg, Alan N.; Bowman, Christopher L.; White, Franklin E.

1999-03-01

The Data Fusion Model maintained by the Joint Directors of Laboratories (JDL) Data Fusion Group is the most widely-used method for categorizing data fusion-related functions. This paper discusses the current effort to revise the expand this model to facilitate the cost-effective development, acquisition, integration and operation of multi- sensor/multi-source systems. Data fusion involves combining information - in the broadest sense - to estimate or predict the state of some aspect of the universe. These may be represented in terms of attributive and relational states. If the job is to estimate the state of a people, it can be useful to include consideration of informational and perceptual states in addition to the physical state. Developing cost-effective multi-source information systems requires a method for specifying data fusion processing and control functions, interfaces, and associate databases. The lack of common engineering standards for data fusion systems has been a major impediment to integration and re-use of available technology: current developments do not lend themselves to objective evaluation, comparison or re-use. This paper reports on proposed revisions and expansions of the JDL Data FUsion model to remedy some of these deficiencies. This involves broadening the functional model and related taxonomy beyond the original military focus, and integrating the Data Fusion Tree Architecture model for system description, design and development.

Cranial electrotherapy stimulation and transcranial pulsed current stimulation: a computer based high-resolution modeling study.

PubMed

Datta, Abhishek; Dmochowski, Jacek P; Guleyupoglu, Berkan; Bikson, Marom; Fregni, Felipe

2013-01-15

The field of non-invasive brain stimulation has developed significantly over the last two decades. Though two techniques of noninvasive brain stimulation--transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS)--are becoming established tools for research in neuroscience and for some clinical applications, related techniques that also show some promising clinical results have not been developed at the same pace. One of these related techniques is cranial electrotherapy stimulation (CES), a class of transcranial pulsed current stimulation (tPCS). In order to understand further the mechanisms of CES, we aimed to model CES using a magnetic resonance imaging (MRI)-derived finite element head model including cortical and also subcortical structures. Cortical electric field (current density) peak intensities and distributions were analyzed. We evaluated different electrode configurations of CES including in-ear and over-ear montages. Our results confirm that significant amounts of current pass the skull and reach cortical and subcortical structures. In addition, depending on the montage, induced currents at subcortical areas, such as midbrain, pons, thalamus and hypothalamus are of similar magnitude than that of cortical areas. Incremental variations of electrode position on the head surface also influence which cortical regions are modulated. The high-resolution modeling predictions suggest that details of electrode montage influence current flow through superficial and deep structures. Finally we present laptop based methods for tPCS dose design using dominant frequency and spherical models. These modeling predictions and tools are the first step to advance rational and optimized use of tPCS and CES. Copyright © 2012 Elsevier Inc. All rights reserved.

Are there financial savings associated with supplementing current diagnostic practice for preeclampsia with a novel test? Learnings from a modeling analysis from a German payer perspective.

PubMed

Hadker, Nandini; Garg, Suchita; Costanzo, Cory; van der Helm, Wim; Creeden, James

2013-05-01

To quantify the financial impact of adding a novel serum test to the current diagnostic toolkit for preeclampsia (PE) detection in Germany. A decision-analytic model was created to quantify the economic impact of adding a recently developed novel diagnostic test for PE (Roche Diagnostics, Rotkreuz, Switzerland) to current diagnostic practice in Germany. The model simulated a cohort of 1000 pregnant patients receiving obstetric care and quantified the budget impact of adding the novel test to current German PE detection and management practices. The model estimates that the costs associated with managing a typical pregnancy in Germany are €941 when the novel test is used versus €1579 with standard practice. This represents savings of €637 per pregnant woman, even when the test is used as a supplementary diagnostic tool. The savings are attributed to the novel test's ability to better classify patients relative to current practice, specifically, its ability to reduce false negatives by 67% and false positives by 71%. The novel PE test has the potential to provide substantial cost savings to German healthcare payers, even when used as an addition to standard practice. Better classification of patients at risk for developing PE and declassification of those that are not compared to current practice leads to economic savings for the healthcare system. Furthermore, by reducing the rates of false-positive and false-negative classification relative to current standard of care, the test helps better target healthcare spending and lowers overall costs associated with PE care.

Young Adults' Exposure to Alcohol- and Marijuana-Related Content on Twitter.

PubMed

Cabrera-Nguyen, E Peter; Cavazos-Rehg, Patricia; Krauss, Melissa; Bierut, Laura J; Moreno, Megan A

2016-03-01

Twitter is among the most popular social media platforms used by young adults, yet it has been underutilized in substance use research compared with older platforms (e.g., MySpace and Facebook). We took a first step toward studying the associations between exposure to pro-alcohol- and marijuana-related content among young adults via Twitter and current heavy episodic drinking and current marijuana use, respectively. We conducted an online survey of 587 (254 men, 333 women) Twitter users between ages 18 and 25 years in February 2014 using an online survey system that has been previously used in research on health behaviors and attitudes. Current heavy episodic drinking was significantly associated with higher levels of exposure to pro-alcohol content. Similarly, current marijuana use was significantly associated with higher levels of exposure to pro-marijuana content. Our findings suggest that in-depth research regarding young adults' exposure to pro-alcohol- and marijuana-related content via Twitter may provide a foundation for developing effective prevention messages on this social media platform to counter the pro-alcohol and marijuana messages.

Airport Privatization: Issues Related to the Sale of U.S. Commercial Airports

DOT National Transportation Integrated Search

1996-02-28

Congressional testimony by Gerald L. Dillingham, Associate Director, : Transportation and Telecommunications Issues, Resources, Community, and : Economic Development Division, General Accounting Office, on the current : extent of private sector parti...

The Language Situation in Tunisia.

ERIC Educational Resources Information Center

Daoud, Mohamed

2001-01-01

Describes the current language situation in Tunisia while maintaining a historical perspective that is helpful in understanding how language-related changes have come about, and a prospective view that may illuminate future developments. (Author/VWL)

GEISA-97 spectroscopic database system related information resources: current status and perspectives

NASA Astrophysics Data System (ADS)

Chursin, Alexei A.; Jacquinet-Husson, N.; Lefevre, G.; Scott, Noelle A.; Chedin, Alain

2000-01-01

This paper presents the recently developed information content diffusion facilities, e.g. the WWW-server of GEISA, MS DOS, WINDOWS-95/NT, and UNIX software packages, associated with the 1997 version of the GEISA-(Gestion et Etude des Informations Spectroscopiques Atmospheriques; word translation: Management and Study of Atmospheric Spectroscopic Information) infrared spectroscopic databank developed at LMD (Laboratoire de Meteorologie Dynamique, France). GEISA-97 individual lines file involves 42 molecules (96 isotopic species) and contains 1,346,266 entries, between 0 and 22,656 cm-1. GEISA-97 also has a catalog of cross-sections at different temperatures and pressures for species (such as chlorofluorocarbons) with complex spectra. The current version of the GEISA-97 cross- section databank contains 4,716,743 entries related to 23 molecules between 555 and 1700 cm-1.

Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries

PubMed Central

Prentice, Boone M.

2013-01-01

Gas-phase ion/ion reactions are emerging as useful and flexible means for the manipulation and characterization of peptide and protein biopolymers. Acid/base-like chemical reactions (i.e., proton transfer reactions) and reduction/oxidation (redox) reactions (i.e., electron transfer reactions) represent relatively mature classes of gas-phase chemical reactions. Even so, especially in regards to redox chemistry, the widespread utility of these two types of chemistries is undergoing rapid growth and development. Additionally, a relatively new class of gas-phase ion/ion transformations is emerging which involves the selective formation of functional-group-specific covalent bonds. This feature details our current work and perspective on the developments and current capabilities of these three areas of ion/ion chemistry with an eye towards possible future directions of the field. PMID:23257901

Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries.

PubMed

Prentice, Boone M; McLuckey, Scott A

2013-02-01

Gas-phase ion/ion reactions are emerging as useful and flexible means for the manipulation and characterization of peptide and protein biopolymers. Acid/base-like chemical reactions (i.e., proton transfer reactions) and reduction/oxidation (redox) reactions (i.e., electron transfer reactions) represent relatively mature classes of gas-phase chemical reactions. Even so, especially in regards to redox chemistry, the widespread utility of these two types of chemistries is undergoing rapid growth and development. Additionally, a relatively new class of gas-phase ion/ion transformations is emerging which involves the selective formation of functional-group-specific covalent bonds. This feature details our current work and perspective on the developments and current capabilities of these three areas of ion/ion chemistry with an eye towards possible future directions of the field.

What Schools Are Doing around Career Development: Implications for Policy and Practice

ERIC Educational Resources Information Center

Perry, Justin C.; Wallace, Eric W.

2012-01-01

This article describes the role that schools are playing in supporting career development for young people. It examines the history of career-related programming in schools, including school-to-work programs, career and technical education, the college and career readiness movement, and current school reform initiatives. This understanding of…

Women's Career Development: Barriers to Learning within the Traditional Workplace.

ERIC Educational Resources Information Center

Poole, Millicent E.; Nielsen, Samuel W.

Two phases of related research investigated the nature of women's skill development needs. The first phase examined prior schooling and current and future training needs of managerial and professional women. A questionnaire was administered to an initial sample of 163 and a replication sample of 207. Participants indicated interpersonal,…

Child Welfare in Canada.

ERIC Educational Resources Information Center

McBroom, Elizabeth, Ed.

1983-01-01

Reflecting the current state of theory and practice in child welfare in Canada, these eight papers suggest a contemporary view of Canadian children and the contexts in which they develop as defined by legal rights and society. First, Henry S. Maas argues that attention to normal social development and its contexts, and to related ongoing theory…

RETRAINING AND MIGRATION AS FACTORS IN REGIONAL ECONOMIC DEVELOPMENT.

ERIC Educational Resources Information Center

SOMERS, GERALD G.

THIS REPORT, PREPARED FOR THE OFFICE OF REGIONAL ECONOMIC DEVELOPMENT, FEATURES A REVIEW OF RECENT RESEARCH ON RETRAINING AND MIGRATION AS INDEPENDENT AND INTERACTING FACTORS IN REGIONAL ECONOMIES. FINDINGS ARE ALSO RELATED TO CURRENT UNITED STATES MANPOWER POLICY AND TO RETRAINING AND RELOCATION SCHEMES IN WESTERN EUROPE. IN THE UNITED STATES,…

Guidelines for Curriculum Development for Undergraduate Medical Education in the Prevention of Pulmonary Diseases.

ERIC Educational Resources Information Center

National Heart, Lung, and Blood Inst. (DHHS/NIH), Bethesda, MD. Div. of Lung Diseases.

These guidelines for developing an undergraduate medical education curriculum in pulmonary disease prevention emphasize not only the most current scientific practice but also the active application of cognitive and behavioral skills related to patient education. Chapter 1 introduces the guidelines and the issues and trends in preventative…

Building Alliance for Preschool Inclusion: Parents of Typically Developing Children, Attitudes and Perceptions

ERIC Educational Resources Information Center

Sira, Natalia; Maine, Erica; McNeil, Sarah

2018-01-01

The current study investigated perceptions, thoughts, and attitudes of parents of typically developing children enrolled in inclusive 3-year-old and 4-year-old preschool classrooms. Using a qualitative approach, guided by ecological system theory semi-structured interviews with parents (N = 7) were completed. Several common themes related to…

Advanced Breeding, Development, and Release of High Biomass Energy Cane Cultivars in Florida

USDA-ARS?s Scientific Manuscript database

Research into alternative energy sources has been on the rise since the 1970s. Novel sources of carbon-neutral energy are currently in high demand, but can pose different challenges in their development. Energy cane is a relatively new generation crop being bred as a source for biofuel feedstock and...

Outlook on Research in Education for Sustainable Development

ERIC Educational Resources Information Center

Grasel, Cornelia; Bormann, Inka; Schutte, Kerstin; Trempler, Kati; Fischbach, Robert

2013-01-01

This article provides an overview of current research on Education for Sustainable Development (ESD). It shows a lack of correspondence between ESD research and recent debates in educational research. Research on ESD has established as a field of research with insufficient relations to other fields in educational research. Based on the overview…

Steps in Theory-of-Mind Development for Children with Deafness or Autism

ERIC Educational Resources Information Center

Peterson, Candida C.; Wellman, Henry M.; Liu, David

2005-01-01

Prior research demonstrates that understanding theory of mind (ToM) is seriously and similarly delayed in late-signing deaf children and children with autism. Are these children simply delayed in timing relative to typical children, or do they demonstrate different patterns of development? The current research addressed this question by testing…

A Catalog of Tasks, Performance Objectives, Performance Guides, Tools, and Equipment, Homemaker Human Development.

ERIC Educational Resources Information Center

Watkins, Betty; And Others

This catalog was designed to provide performance objectives and performance guides associated with current occupational information relating to the job of homemaker. The performance objectives and guides were developed following a literature review and a survey of random samples of homemakers in the five participating states (Alabama, Florida,…

Towards Sustainable National Development through Well Managed Early Childhood Education

ERIC Educational Resources Information Center

Abraham, Nath M.

2012-01-01

This paper discusses issues relating to sustainable development and effective management of early childhood education. The child is the "owner" of the future. The problems that confront the current generation are complex and serious that cannot be addressed in the same way they were created. But they can be addressed. The concept of…

Children and Television: The Development of the Child's Understanding of the Medium.

ERIC Educational Resources Information Center

Wartella, Ellen

This review of the current state of research on how children make sense of television and its content examines age-related differences in children's interpretations of television entertainment content in general, and advertising content in particular. A brief analysis and description of the fundamental principles of cognitive development theory…

Entrepreneurial Universities and the Development of Regional Societies: A Spatial View of the Europe of Knowledge

ERIC Educational Resources Information Center

Kitagawa, Fumi

2005-01-01

This article highlights a range of university entrepreneurship activities and regional engagement in relation to current governance and finance issues. A model for networking and developing partnership between universities and their region is presented, which reflects existing and emerging European level policy instruments. This model aims at…

How do doctors choose where they want to work? - motives for choice of current workplace among physicians registered in Finland 1977-2006.

PubMed

Heikkilä, Teppo Juhani; Hyppölä, Harri; Aine, Tiina; Halila, Hannu; Vänskä, Jukka; Kujala, Santero; Virjo, Irma; Mattila, Kari

2014-02-01

Though there are a number of studies investigating the career choices of physicians, there are only few concerning doctors' choices of workplace. A random sample (N=7758) of physicians licensed in Finland during the years 1977-2006 was surveyed. Respondents were asked: "To what extent did the following motives affect your choice of your current workplace?" Respondents were grouped based on several background variables. The groups were used as independent variables in univariate analysis of covariance (ANCOVA). The factors Good workplace, Career and professional development, Non-work related issues, Personal contacts and Salary were formed and used as dependent variables. There were significant differences between groups of physicians, especially in terms of gender, working sector and specialties. The association of Good workplace, Career and professional development, and Non-work related issues with the choice of a workplace significantly decreased with age. Female physicians were more concerned with Career and professional development and Non-work related issues. Since more females are entering the medical profession and there is an ongoing change of generations, health care organizations and policy makers need to develop a new philosophy in order to attract physicians. This will need to include more human-centric management and leadership, better possibilities for continuous professional development, and more personalized working arrangements depending on physician's personal motives. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Recent Developments in Computed Tomography for Urolithiasis: Diagnosis and Characterization

PubMed Central

Mc Laughlin, P. D.; Crush, L.; Maher, M. M.; O'Connor, O. J.

2012-01-01

Objective. To critically evaluate the current literature in an effort to establish the current role of radiologic imaging, advances in computed tomography (CT) and standard film radiography in the diagnosis, and characterization of urinary tract calculi. Conclusion. CT has a valuable role when utilized prudently during surveillance of patients following endourological therapy. In this paper, we outline the basic principles relating to the effects of exposure to ionizing radiation as a result of CT scanning. We discuss the current developments in low-dose CT technology, which have resulted in significant reductions in CT radiation doses (to approximately one-third of what they were a decade ago) while preserving image quality. Finally, we will discuss an important recent development now commercially available on the latest generation of CT scanners, namely, dual energy imaging, which is showing promise in urinary tract imaging as a means of characterizing the composition of urinary tract calculi. PMID:22952473

Neurocognitive Processes and Pediatric Obesity Interventions: Review of Current Literature and Suggested Future Directions.

PubMed

Miller, Alison L

2016-06-01

Childhood obesity is a significant problem in the United States, but current childhood obesity prevention approaches have limited efficacy. Self-regulation processes organize behavior to achieve a goal and may shape health behaviors and health outcomes. Obesity prevention approaches that focus on the cognitive and behavioral mechanisms that underlie self-regulation early in life may therefore lead to better outcomes. This article reviews the development of executive functioning (EF), identifies influences on EF development, discusses aspects of EF relating to increased risk for childhood obesity, and considers how EF-weight associations may change across development. Implications for intervention are discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

Standardized Semantic Markup for Reference Terminologies, Thesauri and Coding Systems: Benefits for distributed E-Health Applications.

PubMed

Hoelzer, Simon; Schweiger, Ralf K; Liu, Raymond; Rudolf, Dirk; Rieger, Joerg; Dudeck, Joachim

2005-01-01

With the introduction of the ICD-10 as the standard for diagnosis, the development of an electronic representation of its complete content, inherent semantics and coding rules is necessary. Our concept refers to current efforts of the CEN/TC 251 to establish a European standard for hierarchical classification systems in healthcare. We have developed an electronic representation of the ICD-10 with the extensible Markup Language (XML) that facilitates the integration in current information systems or coding software taking into account different languages and versions. In this context, XML offers a complete framework of related technologies and standard tools for processing that helps to develop interoperable applications.

Challenges in reducing dengue burden; diagnostics, control measures and vaccines.

PubMed

Lam, Sai Kit

2013-09-01

Dengue is a major public health concern worldwide, with the number of infections increasing globally. The illness imposes the greatest economic and human burden on developing countries that have limited resources to deal with the scale of the problem. No cure for dengue exists; treatment is limited to rehydration therapy, and with vector control strategies proving to be relatively ineffective, a vaccine is an urgent priority. Despite the numerous challenges encountered in the development of a dengue vaccine, several vaccine candidates have shown promise in clinical development and it is believed that a vaccination program would be at least as cost-effective as current vector control programs. The lead candidate vaccine is a tetravalent, live attenuated, recombinant vaccine, which is currently in Phase III clinical trials. Vaccine introduction is a complex process that requires consideration and is discussed here. This review discusses the epidemiology, burden and pathogenesis of dengue, as well as the vaccine candidates currently in clinical development.

Review of Musculoskeletal Injuries and Prevention in the Endoscopy Practitioner

PubMed Central

2014-01-01

Practitioners of endoscopy often experience musculoskeletal pain and injury (most often in the back, neck, shoulders, hands, wrists, and thumbs) that are associated with the minute and repetitive strain that is placed on these areas during endoscopic procedures. This review of the current documentation of endoscopy-related pain and injuries among practitioners finds that such problems are widespread and specific in kind as well as strongly correlated with high procedure volume and procedure duration. Research on the nature and impact of cumulative trauma and overuse syndromes in other professions such as dentistry, pianists, production labor, and athletics is brought to bear on the work of the endoscopist. A more thorough understanding of the nature and prevalence of work-related pain and injury sustained by endoscopists should inform further development of ergonomic practices and equipment design. This article reviews current recommendations for ergonomic design in the endoscopy procedure space and finds that reported compliance with those recommendations is quite low. Strategies for the management of the risk of musculoskeletal injuries related to the practice of endoscopy include compliance with currently recommended ergonomic practices, education of trainees in ergonomic technique when practicing endoscopy, and research toward the modification and development of more ergonomic endoscopes and procedure spaces. PMID:24798940

Health information and communication system for emergency management in a developing country, Iran.

PubMed

Seyedin, Seyed Hesam; Jamali, Hamid R

2011-08-01

Disasters are fortunately rare occurrences. However, accurate and timely information and communication are vital to adequately prepare individual health organizations for such events. The current article investigates the health related communication and information systems for emergency management in Iran. A mixed qualitative and quantitative methodology was used in this study. A sample of 230 health service managers was surveyed using a questionnaire and 65 semi-structured interviews were also conducted with public health and therapeutic affairs managers who were responsible for emergency management. A range of problems were identified including fragmentation of information, lack of local databases, lack of clear information strategy and lack of a formal system for logging disaster related information at regional or local level. Recommendations were made for improving the national emergency management information and communication system. The findings have implications for health organizations in developing and developed countries especially in the Middle East. Creating disaster related information databases, creating protocols and standards, setting an information strategy, training staff and hosting a center for information system in the Ministry of Health to centrally manage and share the data could improve the current information system.

How To Make a Curriculum: The 1987 Guidelines for Curriculum Development in the Norwegian High School--A New Paradigma in Curriculum Development Practice?

ERIC Educational Resources Information Center

Gundem, Bjorg B.

This paper relates to a research project on the history and current practice of curriculum administration in Norway. An elaboration is provided on the changing high school system and the growing impact of curriculum scholarship on curriculum development. The discussion revolves around three objectives: (1) to determine if the newly formulated set…

A partial Hamiltonian approach for current value Hamiltonian systems

NASA Astrophysics Data System (ADS)

Naz, R.; Mahomed, F. M.; Chaudhry, Azam

2014-10-01

We develop a partial Hamiltonian framework to obtain reductions and closed-form solutions via first integrals of current value Hamiltonian systems of ordinary differential equations (ODEs). The approach is algorithmic and applies to many state and costate variables of the current value Hamiltonian. However, we apply the method to models with one control, one state and one costate variable to illustrate its effectiveness. The current value Hamiltonian systems arise in economic growth theory and other economic models. We explain our approach with the help of a simple illustrative example and then apply it to two widely used economic growth models: the Ramsey model with a constant relative risk aversion (CRRA) utility function and Cobb Douglas technology and a one-sector AK model of endogenous growth are considered. We show that our newly developed systematic approach can be used to deduce results given in the literature and also to find new solutions.

Core Training in Low Back Disorders: Role of the Pilates Method.

PubMed

Joyce, Andrew A; Kotler, Dana H

The Pilates method is a system of exercises developed by Joseph Pilates, which emphasizes recruitment and strengthening of the core muscles, flexibility, and breathing, to promote stability and control of movement. Its focus bears similarity to current evidence-based exercise programs for low back disorders. Spinal stability is a function of three interdependent systems, osseoligamentous, muscular, and neural control; exercise addresses both the muscular and neural function. The "core" typically refers to the muscular control required to maintain functional stability. Prior research has highlighted the importance of muscular strength and recruitment, with debate over the importance of individual muscles in the wider context of core control. Though developed long before the current evidence, the Pilates method is relevant in this setting and clearly relates to current evidence-based exercise interventions. Current literature supports the Pilates method as a treatment for low back disorders, but its benefit when compared with other exercise is less clear.

The evolution of diagnosis-related groups (DRGs): from its beginnings in case-mix and resource use theory, to its implementation for payment and now for its current utilization for quality within and outside the hospital.

PubMed

Goldfield, Norbert

2010-01-01

Policymakers are searching for ways to control health care costs and improve quality. Diagnosis-related groups (DRGs) are by far the most important cost control and quality improvement tool that governments and private payers have implemented. This article reviews why DRGs have had this singular success both in the hospital sector and, over the past 10 years, in ambulatory and managed care settings. Last, the author reviews current trends in the development and implementation of tools that have the key ingredients of DRG success: categorical clinical model, separation of the clinical model from payment weights, separate payment adjustments for nonclinical factors, and outlier payments. Virtually all current tools used to manage health care costs and improve quality do not have these characteristics. This failure explains a key reason for the failure, for example, of the Medicare Advantage program to control health care costs. This article concludes with a discussion of future developments for DRG-type models outside the hospital sector.

Metal- and Polymer-Matrix Composites: Functional Lightweight Materials for High-Performance Structures

NASA Astrophysics Data System (ADS)

Gupta, Nikhil; Paramsothy, Muralidharan

2014-06-01

The special topic "Metal- and Polymer-Matrix Composites" is intended to capture the state of the art in the research and practice of functional composites. The current set of articles related to metal-matrix composites includes reviews on functionalities such as self-healing, self-lubricating, and self-cleaning capabilities; research results on a variety of aluminum-matrix composites; and investigations on advanced composites manufacturing methods. In addition, the processing and properties of carbon nanotube-reinforced polymer-matrix composites and adhesive bonding of laminated composites are discussed. The literature on functional metal-matrix composites is relatively scarce compared to functional polymer-matrix composites. The demand for lightweight composites in the transportation sector is fueling the rapid development in this field, which is captured in the current set of articles. The possibility of simultaneously tailoring several desired properties is attractive but very challenging, and it requires significant advancements in the science and technology of composite materials. The progress captured in the current set of articles shows promise for developing materials that seem capable of moving this field from laboratory-scale prototypes to actual industrial applications.

Current Needs and Future Directions of Occupational Safety and Heath in a Globalized World

PubMed Central

Perera, Frederica P.; Li, TY; Lin, C; Tang, Deliang; Gilbert, Steven G.; Kang, Seong-Kyu; Aschner, Michael

2011-01-01

This summary provides a synopsis of talks included in a symposium entitled “Current Needs and Future Directions of Occupational Safety and Heath in a Globalized World”. The purpose of the symposium was to (1) highlight national and international agencies with occupational health related activities; (2) address electronic (e-)waste issues in developing countries where exposures are secondary to the handling and scavenging of scrap; and (3) discuss the effects of hazardous materials, such as polycyclic aromatic hydrocarbon (PAH) and tobacco smoke on child intelligence quotient (IQ) in developing countries. PMID:22037493

Development and current applications of assisted fertilization.

PubMed

Palermo, Gianpiero D; Neri, Queenie V; Monahan, Devin; Kocent, Justin; Rosenwaks, Zev

2012-02-01

Since the very early establishment of in vitro insemination, it became clear that one of the limiting steps is the achievement of fertilization. Among the different assisted fertilization methods, intracytoplasmic sperm injection emerged as the ultimate technique to allow fertilization with ejaculated, epididymal, and testicular spermatozoa. This work describes the early steps that brought forth the development of intracytoplasmic sperm injection and its role in assisted reproductive techniques. The current methods to select the preferential male gamete will be elucidated and the concerns related to the offspring of severe male factor couples will be discussed. Copyright © 2012. Published by Elsevier Inc.

Neuronavigation in the surgical management of brain tumors: current and future trends

PubMed Central

Orringer, Daniel A; Golby, Alexandra; Jolesz, Ferenc

2013-01-01

Neuronavigation has become an ubiquitous tool in the surgical management of brain tumors. This review describes the use and limitations of current neuronavigational systems for brain tumor biopsy and resection. Methods for integrating intraoperative imaging into neuronavigational datasets developed to address the diminishing accuracy of positional information that occurs over the course of brain tumor resection are discussed. In addition, the process of integration of functional MRI and tractography into navigational models is reviewed. Finally, emerging concepts and future challenges relating to the development and implementation of experimental imaging technologies in the navigational environment are explored. PMID:23116076

Maternal depression and infant development: theory and current evidence.

PubMed

Miklush, Lisa; Connelly, Cynthia D

2013-01-01

Maternal depression (MD) is a condition that has wide-ranging effects on the woman, her family, and the broader global society. It is generally agreed that MD is associated with untoward effects on the developmental trajectory of offspring. The aim of this article is to review the historical and theoretical underpinnings informing current thought linking MD with infant development, and to highlight some of the neuroendocrine and epigenetic processes related to MD and its sequelae. A broad understanding of the association between MD and infant developmental outcomes can inform nursing care of the childbearing family.

Develop and test fuel cell powered on site integrated total energy systems. Phase 3: Full-scale power plant development

NASA Technical Reports Server (NTRS)

Kaufman, A.; Olson, B.; Pudick, S.; Wang, C. L.; Werth, J.; Whelan, J. A.

1986-01-01

The third in a series of 4kW stacks, consisting of 24 cells of the 13 inch x 23 inch cell size, has been on test for about 1600 hours. This stack is similar to the first two stacks, which ran 7000 and 8400 hours, respectively. The present stack incorporates technology improvements relating to the electrolyte-matrix, the current-collector assembly, and a reduction in the number of cooling plates. Performance is currently averaging about 0.64 per cell at 161 mA sq cm.

Syntactic Metals: A Survey of Current Technology

NASA Technical Reports Server (NTRS)

Erikson, Ray

2003-01-01

Syntactic metals are a relatively new development in materials science. Several approaches to synthesizing these materials have been tried, and the handful of researchers in this field are beginning to make progress in defining useful compositions and processes. Syntactic metals can provide materials with dramatically improved specific strength and stiffness over their parent alloys, while retaining the isotropy that makes ordinary metals preferable to fiber-reinforced laminated composites in many applications. This paper reviews syntactic material concepts in general, the current state of the art (including the author's own work in syntactic aluminum), and the direction of future developments.

[Current state of competence assessment in nursing].

PubMed

Darmann-Finck, Ingrid; Reuschenbach, Bernd

2013-01-01

Competency measurement is central to the optimisation of outcome oriented educational processes in nursing, similar to the concept of evidence based practice. The classification of measurement tools provides the basis for describing the current state of research and development in relation to competence measurement in nursing science, and any gaps are identified. The article concludes with questioning the importance of outcome oriented quality orientation in order to achieve an increase in quality during training. Further methodological developments and qualitative studies are needed to examine the context specific processes of interaction and learning, beyond competence diagnostics. Copyright © 2012. Published by Elsevier GmbH.

The Development and Validation of a Scale Assessing Individual Schemas Used in Classifying a Smoker: Implications for Research and Practice

PubMed Central

Nehl, Eric; Sterling, Kymberle; Buchanan, Taneisha; Narula, Shana; Sutfin, Erin; Ahluwalia, Jasjit S.

2011-01-01

Introduction: Half of college students who have smoked in the past month do not consider themselves smokers. Understanding one’s schema of smokers is important, as it might relate to smoking behavior. Thus, we aimed to develop a scale assessing how young adults classify smokers and establish reliability and validity of the scale. Methods: Of 24,055 students at six Southeast colleges recruited to complete an online survey, 4,840 (20.1%) responded, with complete smoking and scale development data from 3,863. Results: The Classifying a Smoker Scale consisted of 10 items derived from prior research. Factor analysis extracted a single factor accounting for 40.00% of score variance (eigenvalue = 5.52). Higher scores (range 10–70) indicate stricter criteria in classifying a smoker. The scale yielded a Cronbach’s alpha of .91. Current smoking (past 30-day) prevalence was 22.8%. Higher Classifying a Smoker Scale scores (p = .001) were significant predictors of current smoking, controlling for sociodemographics. Higher scores were related to being nondaily versus daily smokers (p = .009), readiness to quit in the next month (p = .04), greater perceived smoking prevalence (p = .007), not identifying as smokers (p < .001), less perceived harm of smoking (p < .001), greater concern about smoking health risks (p = .01), and less favorable attitudes toward smoking restrictions (p < .001). Among current smokers, higher scores were related to greater smoking frequency (p = .02), not identifying as smokers (p < .001), and less perceived harm of smoking (p < .001), controlling for sociodemographics. Conclusion: This scale, demonstrating good psychometric properties, highlights potential intervention targets for prevention and cessation, as it relates to smoking, risk perception, and interest in quitting. PMID:21994337

The development and validation of a scale assessing individual schemas used in classifying a smoker: implications for research and practice.

PubMed

Berg, Carla J; Nehl, Eric; Sterling, Kymberle; Buchanan, Taneisha; Narula, Shana; Sutfin, Erin; Ahluwalia, Jasjit S

2011-12-01

Half of college students who have smoked in the past month do not consider themselves smokers. Understanding one's schema of smokers is important, as it might relate to smoking behavior. Thus, we aimed to develop a scale assessing how young adults classify smokers and establish reliability and validity of the scale. Of 24,055 students at six Southeast colleges recruited to complete an online survey, 4,840 (20.1%) responded, with complete smoking and scale development data from 3,863. The Classifying a Smoker Scale consisted of 10 items derived from prior research. Factor analysis extracted a single factor accounting for 40.00% of score variance (eigenvalue = 5.52). Higher scores (range 10-70) indicate stricter criteria in classifying a smoker. The scale yielded a Cronbach's alpha of .91. Current smoking (past 30-day) prevalence was 22.8%. Higher Classifying a Smoker Scale scores (p = .001) were significant predictors of current smoking, controlling for sociodemographics. Higher scores were related to being nondaily versus daily smokers (p = .009), readiness to quit in the next month (p = .04), greater perceived smoking prevalence (p = .007), not identifying as smokers (p < .001), less perceived harm of smoking (p < .001), greater concern about smoking health risks (p = .01), and less favorable attitudes toward smoking restrictions (p < .001). Among current smokers, higher scores were related to greater smoking frequency (p = .02), not identifying as smokers (p < .001), and less perceived harm of smoking (p < .001), controlling for sociodemographics. This scale, demonstrating good psychometric properties, highlights potential intervention targets for prevention and cessation, as it relates to smoking, risk perception, and interest in quitting.

The trials and tribulations of a practitioner-researcher: challenges and lessons learned through testing a feminist-cognitive-relational social work model of practice.

PubMed

Dombo, Eileen A; Bass, Ami P

2014-01-01

In practice with adult women who survived childhood sexual abuse, the field of social work currently lacks an evidence-based intervention. The current interventions, from the 1990s, come primarily from psychologists. The hypothesis that the Feminist-Cognitive-Relational Social Work Model and Intervention will be more effective in decreasing cognitive distortions, and increasing intimacy and relational health when compared to the standard agency intervention was tested in a quasi-experimental study. The challenges in carrying out the study in small, non-profit organizations are explored to highlight the difficulties in developing evidence-based interventions. Changes to implementation that resulted from the research findings are discussed.

State/federal interaction of LANDSAT system and related technical assistance

NASA Technical Reports Server (NTRS)

Tesser, P. A.

1981-01-01

The history of state involvement in LANDSAT systems planning and related efforts is described. Currently 16 states have visual LANDSAT capabilities and 10 others are planning on developing such capabilities. The federal government's future plans for the LANDSAT system, the impacts of recent budget decisions on the systems, and the FY 82 budget process are examined.

Education for Tomorrow or Education for the Individual: What Works for the Future?

ERIC Educational Resources Information Center

Stephenson, Elspeth

2016-01-01

This theoretical paper explores current literature relative to challenges faced by early childhood teachers in relation to the increasing accountability to improve measureable literacy and numeracy skills in young children. This sits within a context which has a developing focus on preparing children for the role they will play in future society.…

A Workshop for Developing Learning Modules for Science Classes Based on Biogeochemical Research

ERIC Educational Resources Information Center

Harrington, James M.; Gardner, Terrence G.; Amoozegar, Aziz; Andrews, Megan Y.; Rivera, Nelson A.; Duckworth, Owen W.

2013-01-01

A challenging aspect of educating secondary students is integrating complex scientific concepts related to modern research topics into lesson plans that students can relate to and understand at a basic level. One method of encouraging the achievement of learning outcomes is to use real-world applications and current research to fuel student…

Positive Side Effects of a Job-Related Training Program for Older Adults in South Korea

ERIC Educational Resources Information Center

Lee, Minhong; Choi, Jae-Sung

2012-01-01

The objective of the current study was to evaluate empirically positive side effects of a job-related training program on older adults' self-esteem, depression, and social networks. A total of 70 older adults participated in the study after completing the Older Paraprofessional Training Program developed and provided by the Continuing Education…

Implications of Outcomes-Based Education for Children with Disabilities. Synthesis Report 6.

ERIC Educational Resources Information Center

Thurlow, Martha L.

This paper examines the concept of "outcomes-based education" (OBE), how it was developed, how it relates to other current reforms that encompass the notion of outcomes, and how it relates to students with disabilities in theory and in practice. Outcomes-based education holds that all children can learn and succeed and that schools are…

ADHD Symptoms Moderate the Relation between ASD Status and Internalizing Symptoms in 3-6-Year-Old Children

ERIC Educational Resources Information Center

Wilson, Beverly J.; Manangan, Christen N.; Dauterman, Hayley A.; Davis, Heather N.

2014-01-01

The current study sought to understand the relation between diagnostic status (autism spectrum disorders [ASD] versus typically developing) and internalizing problems in children with and without co-occurring attention deficit hyperactivity disorder (ADHD) symptoms. Participants were 88 children, ages 3:0-6:11, their parents and teachers. Findings…

Flexible Learning in a Digital World: Experiences and Expectations. Open & Distance Learning Series.

ERIC Educational Resources Information Center

Collis, Betty; Moonen, Jef

This book provides a series of proven, practical guidelines for using technology in education, giving the reader an overview of how technological applications in education can be harnessed and developed. The book presents an integrated vision of how technology is related to learning-related change, and how current and emerging experiences can…

Social Media as a Practical Approach in Engaging Key Stakeholders in School Crisis Communication Plans: A Qualitative Analysis

ERIC Educational Resources Information Center

Agozzino, Alisa; Kaiser, Candace

2014-01-01

The current study examined how public relations specialists within school systems are developing, implementing, and revising their communication crisis plans in an effort to fully engage all key stakeholders. Four research questions and two hypotheses were posed. Members from a state public relations association for schools were asked to…

The Development of Analogy Making in Children: Cognitive Load and Executive Functions

ERIC Educational Resources Information Center

Thibaut, Jean-Pierre; French, Robert; Vezneva, Milena

2010-01-01

The aim of the current study was to investigate the performance of 6-, 8-, and 14-year-olds on an analogy-making task involving analogies in which there are competing perceptual and relational matches. We hypothesized that the selection of the common relational structure requires the inhibition of other salient features, in particular, perceptual…

High School Students in the New Learning Environment: A Profile of Distance E-Learners

ERIC Educational Resources Information Center

Kirby, Dale; Sharpe, Dennis

2010-01-01

The relative ubiquity of computer access and the rapid development of information and communication technology have profoundly impacted teaching and learning at a distance. Relatively little is currently known about the characteristics of those students who participate in distance e-learning courses at the secondary school level. In an effort to…

Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests.

USDA-ARS?s Scientific Manuscript database

The current review is part of a special issue entitled “Role of dietary pattern, foods, nutrients and nutraceuticals in supporting cancer prevention and treatment”; it deals with the description of a pharmacological strategy aiming to actually determine the potential contribution of food-related com...

Eighth Grade In-Service Teachers' Knowledge of Proportional Reasoning and Functions: A Secondary Data Analysis

ERIC Educational Resources Information Center

Masters, Jessica

2012-01-01

A secondary data analysis was conducted using a large dataset from a study related to online professional development for eighth grade teachers of mathematics. Using this data, the paper provides a snapshot of the current state of teachers' knowledge related to proportional reasoning and functions. The paper also considers how teachers' knowledge…

Age-Related Differences in the Temporal Dynamics of Prospective Memory Retrieval: A Lifespan Approach

ERIC Educational Resources Information Center

Mattli, Florentina; Zollig, Jacqueline; West, Robert

2011-01-01

The efficiency of prospective memory (PM) typically increases from childhood to young adulthood and then decreases in later adulthood. The current study used event-related brain potentials (ERPs) to examine the development of the neural correlates of processes associated with the detection of a PM cue, switching from the ongoing activity to the…

The Relation between Executive Function and Theory of Mind Is More than Skin Deep

ERIC Educational Resources Information Center

Carlson, Stephanie M.; Claxton, Laura J.; Moses, Louis J.

2015-01-01

A simple "expression" account of the relation between executive function (EF) and children's developing theory of mind (ToM) has difficulty accounting for the generality of the changes occurring in children's mental-state understanding during the preschool years. The current study of preschool children (N = 43) showed that EF--especially…

The Relations among Theory of Mind, Behavioral Inhibition, and Peer Interactions in Early Childhood

ERIC Educational Resources Information Center

Suway, Jenna G.; Degnan, Kathryn A.; Sussman, Amy L.; Fox, Nathan A.

2012-01-01

The current study examined relations among child temperament, peer interaction, and theory of mind (ToM) development. We hypothesized that: (1) children classified as behaviorally inhibited at 24 months would show less ToM understanding at 36 months in comparison to nonbehaviorally inhibited children; (2) children who displayed negative peer…

Prospective Relations among Fearful Temperament, Protective Parenting, and Social Withdrawal: The Role of Maternal Accuracy in a Moderated Mediation Framework

ERIC Educational Resources Information Center

Kiel, Elizabeth J.; Buss, Kristin A.

2011-01-01

Early social withdrawal and protective parenting predict a host of negative outcomes, warranting examination of their development. Mothers' accurate anticipation of their toddlers' fearfulness may facilitate transactional relations between toddler fearful temperament and protective parenting, leading to these outcomes. Currently, we followed 93…

Current Public Knowledge Pertaining to Traumatic Brain Injury: Influence of Demographic Factors, Social Trends, and Sport Concussion Experience on the Understanding of Traumatic Brain Injury Sequelae.

PubMed

Merz, Zachary C; Van Patten, Ryan; Lace, John

2017-03-01

The current study aimed to assess current broad traumatic brain injury (TBI)-related knowledge in the general public, as well as understanding regarding specific TBI-related conditions including post-concussive syndrome (PCS) and chronic traumatic encephalopathy (CTE). Data were collected from 307 domestic and 73 international individuals via online researcher-developed survey instrumentation utilizing the Amazon Mechanical Turk marketplace, a recently developed website that allows for a streamlined process of survey-based participant recruitment and data collection. Participants completed background demographics questions, a 31-item true/false questionnaire pertaining to TBI-related knowledge, and an inquiry related to willingness to allow (future) child(ren) to participate in several popular U.S. sports. The overall accuracy rate of our U.S. sample was 61%. No accuracy differences were present for gender or geographic region (p's > .05). Participants who self-reported a prior concussion diagnosis, who reported receiving formal concussion training, and who endorsed participation in collegiate, semi-professional, or professional athletic competition, all exhibited lower accuracy rates than the respective comparison groups (p's < .001). Finally, individual item analysis revealed the presence of significant misconceptions pertaining to PCS and CTE. Misconceptions regarding TBI remain highly prevalent within the general public and may be explained, to some extent, by inefficiencies in current TBI-education practices. Moreover, misconceptions regarding PCS and CTE are also prevalent and likely reflect inconsistencies in the scientific literature, coupled with misleading media reports. To combat these trends, greater emphasis must be placed on construct definition within the field and streamlined, efficient communication with the general public. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Longitudinal development of manual motor ability in autism spectrum disorder from childhood to mid-adulthood relates to adaptive daily living skills.

PubMed

Travers, Brittany G; Bigler, Erin D; Duffield, Tyler C; Prigge, Molly D B; Froehlich, Alyson L; Lange, Nicholas; Alexander, Andrew L; Lainhart, Janet E

2017-07-01

Many individuals with autism spectrum disorder (ASD) exhibit motor difficulties, but it is unknown whether manual motor skills improve, plateau, or decline in ASD in the transition from childhood into adulthood. Atypical development of manual motor skills could impact the ability to learn and perform daily activities across the life span. This study examined longitudinal grip strength and finger tapping development in individuals with ASD (n = 90) compared to individuals with typical development (n = 56), ages 5 to 40 years old. We further examined manual motor performance as a possible correlate of current and future daily living skills. The group with ASD demonstrated atypical motor development, characterized by similar performance during childhood but increasingly poorer performance from adolescence into adulthood. Grip strength was correlated with current adaptive daily living skills, and Time 1 grip strength predicted daily living skills eight years into the future. These results suggest that individuals with ASD may experience increasingly more pronounced motor difficulties from adolescence into adulthood and that manual motor performance in ASD is related to adaptive daily living skills. © 2016 John Wiley & Sons Ltd.

Positive Matrix Factorization Model for environmental data analyses

EPA Pesticide Factsheets

Positive Matrix Factorization is a receptor model developed by EPA to provide scientific support for current ambient air quality standards and implement those standards by identifying and quantifying the relative contributions of air pollution sources.

Performance-based design factors for pile foundations.

DOT National Transportation Integrated Search

2014-10-01

The seismic design of pile foundations is currently performed in a relatively simple, deterministic manner. This : report describes the development of a performance-based framework to create seismic designs of pile group : foundations that consider a...

Environmental Awareness: Relating Current Issues to Biology.

ERIC Educational Resources Information Center

DeFina, Anthony

1995-01-01

Presents examples of incorporating environmental issues into lesson plans to raise the level of students' environmental awareness. Topics include: ecology, taxonomy, biochemistry, energy reactions, cell structure and function, genetics and development, and human biology. (JRH)

NASA Space Launch System (SLS) Progress Report

NASA Technical Reports Server (NTRS)

Williams, Tom

2012-01-01

The briefing objectives are: (1) Explain the SLS current baseline architecture and the SLS block-upgrade approach. (2) Summarize the SLS evolutionary path in relation to the Advanced Booster and Advanced Development NASA Research Announcements.

Intelligent transportation systems (ITS) : program and projects

DOT National Transportation Integrated Search

1997-07-01

This is a brief outline of the current projects and programs related to the Intelligent Transportation Systems (ITS) initiatives, formerly known as Intelligent Vehicle Highway Systems (IVHS), being planned, developed, or implemented by the Michigan D...

A State Nurses' Association Perspective.

ERIC Educational Resources Information Center

Boyer, Cheryl M.

1983-01-01

Discusses the accreditation and evolution of continuing education programs developed by state nurses' associations and other nursing organizations and the value of the accreditation. Also relates current accreditation system to the future of professional continuing education. (JOW)

Work-related factors, job satisfaction and intent to leave the current job among United States nurses.

PubMed

Han, Kihye; Trinkoff, Alison M; Gurses, Ayse P

2015-11-01

To examine the relationships of work-related factors (e.g., autonomy, work schedule, supervisory and peer support) to nurses' job satisfaction and intent to leave their current position. Low job satisfaction and high turnover of nurses are major problems for health care. To improve nurse retention, work-related factors associated with job satisfaction and intent to leave should be investigated. A cross-sectional secondary data analysis. Data were obtained in 2004 from Wave 3 of the Nurses' Worklife and Health Study. A random sample of 5000 actively licenced nurses in Illinois and North Carolina (two U.S. states) were sent the survey in wave 1, of which 1641 actively working bedside nurses participated in wave 3. We examined associations of various work-related factors with job satisfaction and intent to leave the current position. Nurses who were dissatisfied with their job reported significantly higher psychological demands and lower autonomy than nurses who were satisfied. Nurses were significantly less satisfied with their jobs when they worked longer hours with inadequate breaks or sick days. Lack of support from peers and supervisors was also related to significantly lower odds of job satisfaction. For intention to leave, nurses who said they planned to leave their current job reported significantly lower autonomy and less support from their peers than nurses who intended to stay. A variety of modifiable work-related factors were significantly related to job satisfaction and intention to leave the current job among nurses. Future research should focus on developing interventions that could mitigate these factors (e.g., by improving work schedules, increasing autonomy and/or nurse support). The impact of such interventions on job satisfaction and intention to leave the current position could then be evaluated. To increase nurse retention, improved schedules, autonomy and supportive work environments should be promoted. © 2015 John Wiley & Sons Ltd.

Proceedings of the NATO Advanced Study Institute on Physics and Applications of Quantum Wells and Superlattices Held in Erice, Italy on 21 April - 1 May 1987. Series B. Volume 170

DTIC Science & Technology

1987-05-01

possibilities and the latter providing a photodetector with low dark currents . Some mention will also be made of structures devised by Nakagawa7 ,8...developments concerning the growth and the characterization of Hgl_xCdxTe-Cdte SLs and related Hg based superlattice systems. These SLs are now currently ...minority carriers in the base region. When a current is flowing, the drift velocities of minority and majority carriers are oppositely directed, and

Investigation of welded joints of aluminium alloys using subminiature eddy-current transducers

NASA Astrophysics Data System (ADS)

Dmitriev, S. F.; Ishkov, A. V.; Katasonov, A. O.; Malikov, V. N.; Sagalakov, A. M.

2018-03-01

The authors developed a measuring system based on subminiaturized eddy-current transducers aimed at examining locally the defects of welded joints in aluminium-magnesium alloy plates connected by means of friction stir welding. The authors made a modification of the Delyann filter, which allowed them to increase considerably the signal-noise relations. The dependency of the eddy-current transducer response on defects was provided, i.e. concealed cuts and openings inside the welded joint, at the frequencies of 100-10000 Hz of the exciting winding.

Necessity and feasibility of improving mental health services in China: A systematic qualitative review.

PubMed

Zhao, Xudong; Liu, Liang; Hu, Chengping; Chen, Fazhan; Sun, Xirong

2017-07-01

It has been nearly 40 years since the reform and opening up of Mainland China. The mental health services system has developed rapidly as a part of the profound socioeconomic changes that ensued. However, its development has not been as substantial as other areas of medical care. For the current qualitative systematic review, we searched databases, including China Biology Medicine disc, Weipu, China National Knowledge Infrastructure, Wanfang digital periodical full text data, China's important newspaper full text database, China Statistical Yearbook database, etc. The content of primary research, literature, and policy papers about the evolution and development of Chinese mental health services was systemically reviewed and analysed by using thematic analysis. Two main themes relative to the necessity and feasibility of reforming the current mental health services system emerged. We discuss 5 corresponding subthemes under the umbrella of the necessity of improving the current treatment, rehabilitation, prevention, and service systems and 7 requirements for the feasibility of reforming the current system. We conclude that as the development of the Chinese economy and the spirit of humanistic care continue, the improvement and reformation of the mental health services system are both necessary and feasible. Copyright © 2017 John Wiley & Sons, Ltd.

The development of shock wave overpressure driven by channel expansion of high current impulse discharge arc

NASA Astrophysics Data System (ADS)

Xiong, Jia-ming; Li, Lee; Dai, Hong-yu; Wu, Hai-bo; Peng, Ming-yang; Lin, Fu-chang

2018-03-01

During the formation of a high current impulse discharge arc, objects near the discharge arc will be strongly impacted. In this paper, a high power, high current gas switch is used as the site of the impulse discharge arc. The explosion wave theory and the arc channel energy balance equation are introduced to analyze the development of the shock wave overpressure driven by the high current impulse discharge arc, and the demarcation point of the arc channel is given, from which the energy of the arc channel is no longer converted into shock waves. Through the analysis and calculation, it is found that the magnitude of the shock wave overpressure caused by impulse discharge arc expansion is closely related to the arc current rising rate. The arc shock wave overpressure will undergo a slow decay process and then decay rapidly. The study of this paper will perform the function of deepening the understanding of the physical nature of the impulse arc discharge, which can be used to explain the damage effect of the high current impulse discharge arc.

Dynamics of tokamak plasma surface current in 3D ideal MHD model

NASA Astrophysics Data System (ADS)

Galkin, Sergei A.; Svidzinski, V. A.; Zakharov, L. E.

2013-10-01

Interest in the surface current which can arise on perturbed sharp plasma vacuum interface in tokamaks was recently generated by a few papers (see and references therein). In dangerous disruption events with plasma-touching-wall scenarios, the surface current can be shared with the wall leading to the strong, damaging forces acting on the wall A relatively simple analytic definition of δ-function surface current proportional to a jump of tangential component of magnetic field nevertheless leads to a complex computational problem on the moving plasma-vacuum interface, requiring the incorporation of non-linear 3D plasma dynamics even in one-fluid ideal MHD. The Disruption Simulation Code (DSC), which had recently been developed in a fully 3D toroidal geometry with adaptation to the moving plasma boundary, is an appropriate tool for accurate self-consistent δfunction surface current calculation. Progress on the DSC-3D development will be presented. Self-consistent surface current calculation under non-linear dynamics of low m kink mode and VDE will be discussed. Work is supported by the US DOE SBIR grant #DE-SC0004487.

Current and planned numerical development for improving computing performance for long duration and/or low pressure transients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faydide, B.

1997-07-01

This paper presents the current and planned numerical development for improving computing performance in case of Cathare applications needing real time, like simulator applications. Cathare is a thermalhydraulic code developed by CEA (DRN), IPSN, EDF and FRAMATOME for PWR safety analysis. First, the general characteristics of the code are presented, dealing with physical models, numerical topics, and validation strategy. Then, the current and planned applications of Cathare in the field of simulators are discussed. Some of these applications were made in the past, using a simplified and fast-running version of Cathare (Cathare-Simu); the status of the numerical improvements obtained withmore » Cathare-Simu is presented. The planned developments concern mainly the Simulator Cathare Release (SCAR) project which deals with the use of the most recent version of Cathare inside simulators. In this frame, the numerical developments are related with the speed up of the calculation process, using parallel processing and improvement of code reliability on a large set of NPP transients.« less

Unconventional energy resources: 2007-2008 review

USGS Publications Warehouse

Warwick, Peter D.; ,

2009-01-01

This paper summarizes five 2007–2008 resource commodity committee reports prepared by the Energy Minerals Division (EMD) of the American Association of Petroleum Geologists. Current United States and global research and development activities related to gas hydrates, gas shales, geothermal resources, oil sands, and uranium resources are included in this review. These commodity reports were written to advise EMD leadership and membership of the current status of research and development of unconventional energy resources. Unconventional energy resources are defined as those resources other than conventional oil and natural gas that typically occur in sandstone and carbonate rocks. Gas hydrate resources are potentially enormous; however, production technologies are still under development. Gas shale, geothermal, oil sand, and uranium resources are now increasing targets of exploration and development, and are rapidly becoming important energy resources that will continue to be developed in the future.

The development of scientific reasoning in medical education: a psychological perspective.

PubMed

Barz, Daniela Luminita; Achimaş-Cadariu, Andrei

2016-01-01

Scientific reasoning has been studied from a variety of theoretical perspectives, which have tried to identify the underlying mechanisms responsible for the development of this particular cognitive process. Scientific reasoning has been defined as a problem-solving process that involves critical thinking in relation to content, procedural, and epistemic knowledge. The development of scientific reasoning in medical education was influenced by current paradigmatic trends, it could be traced along educational curriculum and followed cognitive processes. The purpose of the present review is to discuss the role of scientific reasoning in medical education and outline educational methods for its development. Current evidence suggests that medical education should foster a new ways of development of scientific reasoning, which include exploration of the complexity of scientific inquiry, and also take into consideration the heterogeneity of clinical cases found in practice.

Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design.

PubMed

Kazi, Ada; Chuah, Candy; Majeed, Abu Bakar Abdul; Leow, Chiuan Herng; Lim, Boon Huat; Leow, Chiuan Yee

2018-03-12

Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tools which can be used to lessen the time and cost required for vaccine and antibody development. This approach allows the selection of immunogenic regions from the pathogen genomes. The ideal regions could be developed as potential vaccine candidates to trigger protective immune responses in the hosts. At present, epitope-based vaccines are attractive concepts which have been successfully trailed to develop vaccines which target rapidly mutating pathogens. In this article, we provide an overview of the current progress of immunoinformatics and their applications in the vaccine design, immune system modeling and therapeutics.

Stage-discharge relations for Black Warrior River at Warrior Dam near Eutaw, Alabama; updated 1985

USGS Publications Warehouse

Nelson, G.H.; Ming, C.O.

1986-01-01

The construction of Warrior Dam, completed in 1962, has resulted in changes to the stage-discharge relations in the vicinity. The scarcity of current-meter measurements, coupled with backwater conditions, make definition of a single stage-discharge relation impossible without considerable error. However, as a useful alternative, limit curves were developed in 1983 that defined the limits of possible stage-discharge relations at the dam tailwater section. Since the 1983 report, 37 discharge values computed through the dam for the flood of December 1983 were used to verify or update the lower end of the limit curves. Data obtained from a current-meter measurement of the February 1961 flood (furnished by the U.S. Army Corps of Engineers) were used to update the upper end of the curves. This report presents the updated information. (USGS)

[How to integrate humanization and technology in nursing training].

PubMed

Meyer, Dagmar Estermann

2002-01-01

This paper discusses the current incorporation of the subject of humanization of care in the current context of Brazilian nursing. The relation between nursing and technology is approached, in this study, from a historical perspective. The study also develops the proposition of "human re-signification", having as reference the concept of Cyborg, considering the way this concept has been employed in the contemporary cultural and feminist theoretical framework.

Education for the Aging; Living with a Purpose as Older Adults through Education: An Overview of Current Developments.

ERIC Educational Resources Information Center

Grabowski, Stanley M., Ed.; Mason, W. Dean, Ed.

Directed toward the practitioner, the book is a compilation by 18 knowledgeable, experienced authors of some of the recent literature and current practices in the field relating to aging. The book consists of seven parts: (1) The Older Adult as Learner, (2) The Role of Education in an Aging Society, (3) The Aging Individual and the Changing Nature…

Air Force Geophysics Laboratory Management Information System Study.

DTIC Science & Technology

1985-11-01

management information system (MIS) at AFGL. The study summarizes current management and administrative practices at AFGL. Requirements have been identified for automating several currently manual functions to compile accurate and timely information to better manage and plan AFGL programs. This document describes the functions and relative priorities of five MIS subsystems and provides suggestions for implementation solutions. Creation of a detailed Development Plan is recommended as the follow-on task.

Channel bed particle size distribution procedure used to evaluate watershed cumulative effects for range permit re-issuance on the Santa Fe National Forest

Treesearch

Bruce Sims; Jim Piatt; Lee Johnson; Carol Purchase; John Phillips

1996-01-01

Personnel on the Santa Fe National Forest used methodologies adapted from Bevenger and King (1995) to collect base line particle size data on streams within grazing allotments currently scheduled for permit reissuance. This information was used to determine the relative current health of the watersheds as well as being used in the development of potential alternatives...

A new generation of medical cyclotrons for the 90`s

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. They will also discussmore » the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA.« less

Low-rank coal study: national needs for resource development. Volume 3. Technology evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-11-01

Technologies applicable to the development and use of low-rank coals are analyzed in order to identify specific needs for research, development, and demonstration (RD and D). Major sections of the report address the following technologies: extraction; transportation; preparation, handling and storage; conventional combustion and environmental control technology; gasification; liquefaction; and pyrolysis. Each of these sections contains an introduction and summary of the key issues with regard to subbituminous coal and lignite; description of all relevant technology, both existing and under development; a description of related environmental control technology; an evaluation of the effects of low-rank coal properties on the technology;more » and summaries of current commercial status of the technology and/or current RD and D projects relevant to low-rank coals.« less

On the nature of implicit soul beliefs: when the past weighs more than the present.

PubMed

Anglin, Stephanie M

2015-06-01

Intuitive childhood beliefs in dualism may lay the foundation for implicit soul and afterlife beliefs, which may diverge from explicit beliefs formed later in adulthood. Brief Implicit Association Tests were developed to investigate the relation of implicit soul and afterlife beliefs to childhood and current beliefs. Early but not current beliefs covaried with implicit beliefs. Results demonstrated greater discrepancies in current than in childhood soul and afterlife beliefs among religious groups, and no differences in implicit beliefs. These findings suggest that implicit soul and afterlife beliefs diverge from current self-reported beliefs, stemming instead from childhood beliefs. © 2014 The British Psychological Society.

Taxonomic examination of longgu (Fossilia Ossis Mastodi, "dragon bone") and a related crude drug, longchi (Dens Draconis, "dragon tooth"), from Japanese and Chinese crude drug markets.

PubMed

Oguri, Kazuki; Nishioka, Yuichiro; Kobayashi, Yoshitsugu; Takahashi, Kyoko

2017-07-01

Longgu ("dragon bone," Ryu-kotsu, Fossilia Ossis Mastodi, or Os Draconis) is the only fossil crude drug listed in the Japanese Pharmacopoeia. All longgu in the current Japanese market is imported from China, where its resources are being depleted. Therefore, effective countermeasures are urgently needed to prevent resource depletion. One possible solution is the development of a substitute made from bones of contemporary animals that are closely related to the original animal source of the current longgu. However, no research has been conducted on the original animal source of longgu, except for a report on the longgu specimens present in the Shosoin Repository. Taxonomic examination was performed on the fossil specimens related to longgu which are owned by the Museum of Osaka University, Japan. In total, 20,939 fossil fragments were examined, of which 20,886 were mammalian fossils, and 246 of these fossils were classified into nine families. The longgu specimens from the Japanese market belonged to a relatively smaller variety of taxa than those from the Chinese market. Despite the variety of taxa in longgu, medical doctors using Kampo preparations with longgu have not reported any problems due to the presence of impurities in the original animal source. These results suggest that the effect of longgu is independent of its origin as long as it is closely related to the origin of the current longgu. Thus, despite the considerable effects of fossilization, our results could help in developing an optimal substitute for longgu.

Pituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia.

PubMed

Cullen, A E; Day, F L; Roberts, R E; Pariante, C M; Laurens, K R

2015-11-01

Pituitary volume enlargements have been observed among individuals with first-episode psychosis. These abnormalities are suggestive of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, which may contribute to the development of psychosis. However, the extent to which these abnormalities characterize individuals at elevated risk for schizophrenia prior to illness onset is currently unclear, as volume increases, decreases and no volume differences have all been reported relative to controls. The current study aimed to determine whether antipsychotic-naive, putatively at-risk children who present multiple antecedents of schizophrenia (ASz) or a family history of illness (FHx) show pituitary volume abnormalities relative to typically developing (TD) children. An additional aim was to explore the association between pituitary volume and experiences of psychosocial stress. ASz (n = 30), FHx (n = 22) and TD (n = 32) children were identified at age 9-12 years using a novel community-screening procedure or as relatives of individuals with schizophrenia. Measures of pituitary volume and psychosocial stress were obtained at age 11-14 years. Neither ASz nor FHx children showed differences in pituitary volume relative to TD children. Among FHx children only, pituitary volume was negatively associated with current distress relating to negative life events and exposure to physical punishment. The lack of pituitary volume abnormalities among ASz and FHx children is consistent with our previous work demonstrating that these children are not characterized by elevated diurnal cortisol levels. The findings imply that these biological markers of HPA axis hyperactivity, observed in some older samples of high-risk individuals, may emerge later, more proximally to disease onset.

Relatives’ level of satisfaction with advanced cancer care in Greenland – a mixed methods study

PubMed Central

Augustussen, Mikaela; Hounsgaard, Lise; Pedersen, Michael Lynge; Sjøgren, Per; Timm, Helle

2017-01-01

ABSTRACT Palliative cancer care in Greenland is provided by health professionals at local level, the national Queen Ingrid’s Hospital and at Rigshospitalet in Denmark. To improve and develop care for relatives of patients with advanced cancer, we conducted a mixed method study examining relatives’ level of satisfaction with care and treatment and their current main concerns. The aim was to investigate relatives’ level of satisfaction with advanced cancer care and bring to light their current main concerns. The FAMCARE-20 questionnaire was translated to Greenlandic and pilot tested. The questionnaire was supplemented by open-ended questions about relative’s current main concerns and analyzed with a phenomenological hermeneutical approach. Greenlandic patients with advanced cancer who were previously participating in a prospective study were asked if their closest adult relative would participate in the study. Telephone interviews were conducted and relatives responded to the questionnaire. A total of thirty-two relatives were contacted by telephone and 30 (94%) completed the FAMCARE-20 questionnaire and answered open-ended questions. The highest rate of satisfaction was with the availability of a hospital bed (66%) and relatives were the most dissatisfied with the lack of inclusion in decision making related to treatment and care (71%) and the length of time required to diagnose cancer (70%). Responses to the open-ended questions revealed that relatives faced challenges in gaining access to information from health professionals. They experienced a lack of security, worries about the future and a lack of support at home. The study showed a substantial level of dissatisfaction among relatives of patients with advanced cancer. We strongly recommend a focus on psychosocial care, more access to information and to include relatives in decision making and in the future planning of palliative care services. An assessment of relatives’ needs is essential to develop an adequate palliative care in a range of settings. PMID:28613119

A numerical study of the South China Sea Warm Current during winter monsoon relaxation

NASA Astrophysics Data System (ADS)

Zhang, Cong; Ding, Yang; Bao, Xianwen; Bi, Congcong; Li, Ruixiang; Zhang, Cunjie; Shen, Biao; Wan, Kai

2018-03-01

Using a Finite-Volume Community Ocean Model, we investigated the dynamic mechanism of the South China Sea Warm Current (SCSWC) in the northern South China Sea (NSCS) during winter monsoon relaxation. The model reproduces the mean surface circulation of the NSCS during winter, while model-simulated subtidal currents generally capture its current pattern. The model shows that the current over the continental shelf is generally southwestward, under a strong winter monsoon condition, but a northeastward counter-wind current usually develops between 50-and 100-m isobaths, when the monsoon relaxes. Model experiments, focusing on the wind relaxation process, show that sea level is elevated in the northwestern South China Sea (SCS), related to the persistent northeasterly monsoon. Following wind relaxation, a high sea level band builds up along the mid-shelf, and a northeastward current develops, having an obvious vertical barotropic structure. Momentum balance analysis indicates that an along-shelf pressure gradient provides the initial driving force for the SCSWC during the first few days following wind relaxation. The SCSWC subsequently reaches a steady quasi-geostrophic balance in the cross-shelf direction, mainly linked to sea level adjustment over the shelf. Lagrangian particle tracking experiments show that both the southwestward coastal current and slope current contribute to the northeastward movement of the SCSWC during winter monsoon relaxation.

Current Standardization and Cooperative Efforts Related to Industrial Information Infrastructures.

DTIC Science & Technology

1993-05-01

Data Management Systems: Components used to store, manage, and retrieve data. Data management includes knowledge bases, database management...Application Development Tools and Methods X/Open and POSIX APIs Integrated Design Support System (IDS) Knowledge -Based Systems (KBS) Application...IDEFlx) Yourdon Jackson System Design (JSD) Knowledge -Based Systems (KBSs) Structured Systems Development (SSD) Semantic Unification Meta-Model

Solar Electricity Generation: Issues of Development and Impact on ICT Implementation in Africa

ERIC Educational Resources Information Center

Damasen, Ikwaba Paul

2013-01-01

Purpose: The purpose of this paper is to examine and discuss, in-depth, how solar electricity can be developed and used to tackle grid electricity-related problems in African countries suffering from unreliable and inadequate grid electricity. Design/methodology/approach: The paper discusses in depth the current status of grid electricity in…

Developing an Open Resource Bank for Interactive Teaching of STEM: Perspecives of School Teachers and Teacher Educators

ERIC Educational Resources Information Center

Hassler, Bjoern; Hennessy, Sara; Knight, Simon; Connolly, Teresa

2014-01-01

Much of the current literature related to Open Educational Resource (OER) development and practice concentrates on higher education, although a growing body of work is also emerging for the primary and secondary school sectors. This article examines the user perspectives of teachers and teacher educators, regarding: discovery of teaching…

A Methodology for Data Structure Assessment in Higher Education Administration. AIR Forum Paper 1978.

ERIC Educational Resources Information Center

Baltes, Kenneth G.; Hendrix, Vernon L.

Two recent developments in management information system technology and higher education administration have brought about the need for this study, designed to develop a methodology for revealing a relational model of the data base that administrators are operating from currently or would like to be able to operate from in the future.…

Child Labour and Educational Success in Portugal

ERIC Educational Resources Information Center

Goulart, Pedro; Bedi, Arjun S.

2008-01-01

The current debate on child labour focuses on developing countries. However, Portugal is an example of a relatively developed country where child labour is still a matter of concern as between 8% and 12% of Portuguese children may be classified as workers. This paper studies the patterns of child labour in Portugal and assesses the consequences of…

Development and Application of Intelligence Tests for the Blind: A Research Utilization Conference. Final Report.

ERIC Educational Resources Information Center

Curtis, W. Scott

The purpose of this project was to inquire into the current status of development, past use, availability, and future planning of intelligence tests for the visually handicapped in relation to the fields of psychological, educational, and vocational counseling. The project procedure was that of a research utilization conference involving the…

The Academic Gap: An International Comparison of the Time Allocation of Academically Talented Students

ERIC Educational Resources Information Center

Makel, Matthew C.; Wai, Jonathan; Putallaz, Martha; Malone, Patrick S.

2015-01-01

Despite growing concern about the need to develop talent across the globe, relatively little empirical research has examined how students develop their academic talents. Toward this end, the current study explored how academically talented students from the United States and India spend their time both in and out of school. Indian students…

Exploring the Meso-System: The Roles of Community, Family, and Peers in Adolescent Delinquency and Positive Youth Development

ERIC Educational Resources Information Center

Smith, Emilie Phillips; Faulk, Monique; Sizer, Monteic A.

2016-01-01

Community contexts are important ecological settings related to problem behavior and positive youth development (PYD). While substantial work has focused on neighborhood disadvantage, the current study explores the role of community assets, specifically linkages to important institutional resources and people in those settings. These concepts are…

Marketing Informal Education Institutions in Israel: The Centrality of Customers' Active Involvement in Service Development

ERIC Educational Resources Information Center

Oplatka, Izhar

2004-01-01

The current paper outlines a unique marketing perspective that prevails in some informal education institutions in Israel parallel with "traditional modes of marketing", such as promotion, public relations and the like. Based on a case study research in five community centres, a service development based on active participation of the…

Development and Preliminary Psychometric Evaluation of the Domestic Violence-Related Financial Issues Scale (DV-FI)

ERIC Educational Resources Information Center

Weaver, Terri L.; Sanders, Cynthia K.; Campbell, Carole L.; Schnabel, Meg

2009-01-01

Intimate partner violence (IPV) occurs at disproportionate rates within impoverished groups of women and can include economic abuse as a form of psychological maltreatment. The current study developed a comprehensive assessment of the unique financial issues facing female victims of IPV using a sheltered sample (N = 113). An exploratory factor…

Examining the Benefits of a Faculty Technology Mentoring Program on Graduate Students' Professional Development

ERIC Educational Resources Information Center

Baran, Evrim

2016-01-01

Higher education environments need further evidence of the impact of faculty technology mentoring (FTM) models on graduate students to promote and sustain these programs as well as develop policies related to their support. To address this need, the current study investigated the impact of a university-wide FTM program on participating graduate…

Urbanization in Thailand. An International Urbanization Survey Report to the Ford Foundation.

ERIC Educational Resources Information Center

Romm, Jeff

The primary intentions of this report are to describe urbanization in Thailand to the extent that available information permits, to relate it to development and development planning, and to identify gaps in current knowledge that are likely to become significant in the formulation of future policies and programs. The first section,…

The Role of Heads of Department in the Professional Development of Educators: A Distributed Leadership Perspective

ERIC Educational Resources Information Center

du Plessis, André; Eberlein, Eric

2018-01-01

The qualitative study reported on was, undertaken from a distributed leadership perspective, and was an attempt to provide understanding of how heads of department (HoDs) develop educators within the organisational context of different schools and subject departments. The findings are related to the current policy framework for professional…

Current and Emerging Technology Approaches in Genomics

PubMed Central

Conley, Yvette P.; Biesecker, Leslie G.; Gonsalves, Stephen; Merkle, Carrie J.; Kirk, Maggie; Aouizerat, Bradley E.

2013-01-01

Purpose To introduce current and emerging approaches that are being utilized in the field of genomics so the reader can conceptually evaluate the literature and appreciate how these approaches are advancing our understanding of health-related issues. Organizing Construct Each approach is described and includes information related to how it is advancing research, its potential clinical utility, exemplars of current uses, challenges related to technologies used for these approaches, and when appropriate information related to understanding the evidence base for clinical utilization of each approach is provided. Web-based resources are included for the reader who would like more in-depth information and to provide opportunity to stay up to date with these approaches and their utility. Conclusions The chosen approaches– genome sequencing, genome-wide association studies, epigenomics, and gene expression– are extremely valuable approaches for collecting research data to help us better understand the pathophysiology of a variety of health-related conditions, but they are also gaining in utility for clinical assessment and testing purposes. Clinical Relevance Our increased understanding of the molecular underpinnings of disease will assist with better development of screening tests, diagnostic tests, tests that allow us to prognosticate, tests that allow for individualized treatments, and tests to facilitate post-treatment surveillance. PMID:23294727

Non-inductive current generation in fusion plasmas with turbulence

NASA Astrophysics Data System (ADS)

Wang, Weixing; Ethier, S.; Startsev, E.; Chen, J.; Hahm, T. S.; Yoo, M. G.

2017-10-01

It is found that plasma turbulence may strongly influence non-inductive current generation. This may have radical impact on various aspects of tokamak physics. Our simulation study employs a global gyrokinetic model coupling self-consistent neoclassical and turbulent dynamics with focus on electron current. Distinct phases in electron current generation are illustrated in the initial value simulation. In the early phase before turbulence develops, the electron bootstrap current is established in a time scale of a few electron collision times, which closely agrees with the neoclassical prediction. The second phase follows when turbulence begins to saturate, during which turbulent fluctuations are found to strongly affect electron current. The profile structure, amplitude and phase space structure of electron current density are all significantly modified relative to the neoclassical bootstrap current by the presence of turbulence. Both electron parallel acceleration and parallel residual stress drive are shown to play important roles in turbulence-induced current generation. The current density profile is modified in a way that correlates with the fluctuation intensity gradient through its effect on k//-symmetry breaking in fluctuation spectrum. Turbulence is shown to deduct (enhance) plasma self-generated current in low (high) collisionality regime, and the reduction of total electron current relative to the neoclassical bootstrap current increases as collisionality decreases. The implication of this result to the fully non-inductive current operation in steady state burning plasma regime should be investigated. Finally, significant non-inductive current is observed in flat pressure region, which is a nonlocal effect and results from turbulence spreading induced current diffusion. Work supported by U.S. DOE Contract DE-AC02-09-CH11466.

Cannabis use and incidence of testicular cancer: a 42-year follow-up of Swedish men between 1970 and 2011

PubMed Central

Callaghan, Russell C.; Allebeck, Peter; Akre, Olof; McGlynn, Katherine A.; Sidorchuk, Anna

2018-01-01

Background Given current drug-policy reforms to decriminalize or legalize cannabis in numerous countries worldwide, it is critically important to understand the potential impacts of cannabis use on the development of cancer. The current study aims to assess the relation between cannabis use and the development of testicular cancer. Method The current study relied on a population-based sample (n = 49 343) of young men aged 18–21 years who underwent conscription assessment for Swedish military service in 1969–1970. The conscription process included a non-anonymous questionnaire eliciting information about drug use. Individual-level conscription information was linked to Swedish health and social registry data. Testicular cancers diagnosed between 1970 and 2011 were identified by ICD-7/8/9/10 testicular cancer codes in the Swedish National Patient Register, the Cancer Register, or the Cause of Death Register. Cox regression modeling was used to estimate the hazards associated with cannabis use and time to diagnosis of testicular cancer. Results No evidence was found of a significant relation between lifetime “ever” cannabis use and the subsequent development of testicular cancer [n = 45 250; 119 testicular cancer cases; adjusted hazard ratio (AHR) 1.42, 95% CI, 0.83, 2.45]. “Heavy” cannabis use (defined as usage of more than 50 times in lifetime, as measured at conscription) was associated with the incidence of testicular cancer (n = 45 250; 119 testicular cancer cases; AHR 2.57, 95% CI, 1.02, 6.50). Conclusion The current study provides additional evidence to the limited prior literature suggesting cannabis use may contribute to the development of testicular cancer. PMID:29093004

Neuroanatomy of Individual Differences in Language in Adult Males with Autism

PubMed Central

Lai, Meng-Chuan; Lombardo, Michael V.; Ecker, Christine; Chakrabarti, Bhismadev; Suckling, John; Bullmore, Edward T.; Happé, Francesca; Murphy, Declan G. M.; Baron-Cohen, Simon

2015-01-01

One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural language are associated with current neuroanatomy. Groups with and without language delay differed behaviorally in early social reciprocity, current language, but not current autistic features. Language delay was associated with larger total gray matter (GM) volume, smaller relative volume at bilateral insula, ventral basal ganglia, and right superior, middle, and polar temporal structures, and larger relative volume at pons and medulla oblongata in adulthood. Despite this heterogeneity, those with and without language delay showed significant commonality in morphometric features when contrasted with matched neurotypical individuals (n = 57). In ASC, better current language was associated with increased GM volume in bilateral temporal pole, superior temporal regions, dorsolateral fronto-parietal and cerebellar structures, and increased white matter volume in distributed frontal and insular regions. Furthermore, current language–neuroanatomy correlation patterns were similar across subgroups with or without language delay. High-functioning adult males with ASC show neuroanatomical variations associated with both developmental and current language characteristics. This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity. PMID:25249409

The Rise and Fall of the Gene.

ERIC Educational Resources Information Center

Mahadeva, Madhu; Randerson, Sherman

1985-01-01

Summarizes the current state of genetics, highlighting major historical events in the development of the field and discussing topics related to introns ("silent" or noncoding base sequences in eucaryotic genes) and exons (the coding parts of DNA). (JN)

Five-year ITS program plan

DOT National Transportation Integrated Search

2000-09-01

The current performance-related specifications (PRS) methodology has been under development by the Federal Highway Administration (FHWA) for several years and has now reached a level at which it can be implemented by State highway agencies. PRS for h...

NASA's Microgravity Technology Report: Summary of Activities 1997

NASA Technical Reports Server (NTRS)

Woodard, Dan

1998-01-01

The purpose of the 1997 NASA Microgravity Technology Report is to update the Microgravity Research Program's technology development policy and to present and assess current technology related activities and requirements identified within its research and technology disciplines.

Science, Theology and New Civilization

NASA Astrophysics Data System (ADS)

Theodossiou, E.; Manimanis, V. N.; Danezis, E.

2010-07-01

This work explores the relation and interdependence among theology, science and social structure within the framework of a new “Cultural Current”, which will probably prevail in the Western societies, through the study of the development of the cultural currents in the ages. The now prevailing in these societies Positivist Cultural Current suffers from the weakness that it is no longer supported by the modern scientific theories of physics and other natural sciences. The new reality will include a more philosophical view of science, and a re-harmonization of its relations with the other two “cultural pillars” on which human societies are based: the sociopolitical (social philosophy) and the metaphysical (inner philosophy).

[Perspectives of psychological aging research].

PubMed

Wahl, H-W; Diegelmann, M

2015-12-01

Psychological aging research (PAF) focuses on age-related changes and behavioral stability (e.g. structure of social relations), performance and competences (e.g. cognitive functioning) as well as experiences (e.g. well-being) in advanced age. Knowledge is based in particular on currently available longitudinal studies, which historically for the first time allow very long observational periods (nearly across the complete life span). Additionally, innovative statistical analytical methods co-developed in the PAF nowadays allow a better understanding of the dynamics of change than ever before. This results in a new picture of psychological aging that confirms the multifaceted strengths of human aging but also reveals new risks of the current "prolonged aging".

How can the study of physiological reactivity contribute to our understanding of adversity and resilience processes in development?

PubMed

Obradović, Jelena

2012-05-01

The focus of this article is to present current progress in understanding the interplay among adversity, physiological sensitivity to context, and adaptive functioning, with an emphasis on implications and future directions for resilience researchers. It includes a review of current literature that demonstrates (a) links between various levels of adversity exposure and variability in physiological reactivity, (b) how the interplay between children's physiological reactivity and different sources of risk and adversity relates to variability in adaptive functioning, and (c) various approaches for capturing a more dynamic nature of physiological reactivity and related processes. Throughout, important conceptual and empirical issues are highlighted.

Lightweight, Room-Temperature CO2 Gas Sensor Based on Rare-Earth Metal-Free Composites-An Impedance Study.

PubMed

Willa, Christoph; Schmid, Alexander; Briand, Danick; Yuan, Jiayin; Koziej, Dorota

2017-08-02

We report a light, flexible, and low-power poly(ionic liquid)/alumina composite CO 2 sensor. We monitor the direct-current resistance changes as a function of CO 2 concentration and relative humidity and demonstrate fast and reversible sensing kinetics. Moreover, on the basis of the alternating-current impedance measurements we propose a sensing mechanism related to proton conduction and gas diffusion. The findings presented herein will promote the development of organic/inorganic composite CO 2 gas sensors. In the future, such sensors will be useful for numerous practical applications ranging from indoor air quality control to the monitoring of manufacturing processes.

EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health-related quality of life measures.

PubMed

Muraro, A; Dubois, A E J; DunnGalvin, A; Hourihane, J O'B; de Jong, N W; Meyer, R; Panesar, S S; Roberts, G; Salvilla, S; Sheikh, A; Worth, A; Flokstra-de Blok, B M J

2014-07-01

Instruments have been developed and validated for the measurement of health-related quality of life in patients with food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group. It draws on a systematic review of the literature on quality of life instruments for food allergy and the Appraisal of Guidelines for Research & Evaluation (AGREE II) guideline development process. Guidance is provided on the use of such instruments in research, and the current limitations of their use in clinical practice are described. Gaps in current knowledge as well as areas of future interest are also discussed. This document is relevant to healthcare workers dealing with food-allergic patients, scientists engaging in food allergy research and policy makers involved in regulatory aspects concerning food allergy and safety. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Interventions addressing general parenting to prevent or treat childhood obesity.

PubMed

Gerards, Sanne M P L; Sleddens, Ester F C; Dagnelie, Pieter C; de Vries, Nanne K; Kremers, Stef P J

2011-06-01

Observational studies increasingly emphasize the impact of general parenting on the development of childhood overweight and obesity. The aim of the current literature review was to provide an overview of interventions addressing general parenting in order to prevent or treat childhood obesity. Electronic literature databases were systematically searched for relevant studies. Seven studies were eligible for inclusion. The studies described four different general parenting programs, which were supplemented with lifestyle components (i.e., physical activity and nutrition). All studies showed significant small to moderate intervention effects on at least one weight-related outcome measure. The current review shows that despite the emerging observational evidence for the role of parenting in children's weight-related outcomes, few interventions have been developed that address general parenting in the prevention of childhood obesity. These interventions provide evidence that the promotion of authoritative parenting is an effective strategy for the prevention and management of childhood obesity.

Investigating the respiratory health of deployed military personnel.

PubMed

Morris, Michael J; Zacher, Lisa L; Jackson, David A

2011-10-01

Recent news media articles have implied a direct relationship between environmental exposures such as burn pits during current deployments and the development of serious and debilitating chronic pulmonary disease. These articles suggest that the military is superficially investigating evidence that establishes a link between deployment and development of chronic lung disease. Anecdotal cases of military personnel with lung disease are detailed to suggest a systemic problem with undiagnosed and untreated pulmonary disease in deployed service members. Despite these contentions, the U.S. Army Medical Department and other agencies have been actively pursuing numerous scientific investigations into deployment-related lung disease to define the severity and prevalence of the issue. This article will review relevant research efforts by the U.S. military in the existing medical literature and address the current efforts planned by the services to systematically investigate the possibility of deployment-related pulmonary disease.

Validation of the BUV satellite ozone sensor using the rocket ozonesonde

NASA Technical Reports Server (NTRS)

Thomas, R. W. L.; Pearce, W. A.; Holland, A. C.; Wright, D. U.

1982-01-01

Satellite instruments such as the backscattered ultraviolet (BUV) apparatus, have been in operation for a number of years. One current difficulty is the validation of the ozone inferences obtained from the BUV measurements using independent instruments. For higher altitudes rocket instruments are necessary. Two instruments currently under development include a chemiluminescent detector described by Hilsenrath et al. (1969) and a filter photometer rocket ozonesonde (Rocoz) developed by Krueger and McBridge (1968). The present investigation is concerned with an analysis of the Rocoz system, the information content of the measurements, and the utility of the system for intercomparison with the BUV system. It is found that the sampling characteristics of the Rocoz and BUV systems exhibit some fundamental differences. However, their results can be related through knowledge of the relation between pressure and altitude. This is best obtained through the solution of the hypsometric equation using rocket temperature measurements.

Data-Dictionary-Editing Program

NASA Technical Reports Server (NTRS)

Cumming, A. P.

1989-01-01

Access to data-dictionary relations and attributes made more convenient. Data Dictionary Editor (DDE) application program provides more convenient read/write access to data-dictionary table ("descriptions table") via data screen using SMARTQUERY function keys. Provides three main advantages: (1) User works with table names and field names rather than with table numbers and field numbers, (2) Provides online access to definitions of data-dictionary keys, and (3) Provides displayed summary list that shows, for each datum, which data-dictionary entries currently exist for any specific relation or attribute. Computer program developed to give developers of data bases more convenient access to the OMNIBASE VAX/IDM data-dictionary relations and attributes.

Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors

PubMed Central

Homma, Kohei; Okamoto, Satoshi; Mandai, Michiko; Gotoh, Norimoto; Rajasimha, Harsha K.; Chang, Yi-Sheng; Chen, Shan; Li, Wei; Cogliati, Tiziana; Swaroop, Anand; Takahashi, Masayo

2013-01-01

Replacement of dysfunctional or dying photoreceptors offers a promising approach for retinal neurodegenerative diseases, including age-related macular degeneration and retinitis pigmentosa. Several studies have demonstrated the integration and differentiation of developing rod photoreceptors when transplanted in wild type or degenerating retina; however, the physiology and function of the donor cells are not adequately defined. Here, we describe the physiological properties of developing rod photoreceptors that are tagged with GFP driven by the promoter of rod differentiation factor, Nrl. GFP-tagged developing rods show Ca2+ responses and rectifier outward currents that are smaller than those observed in fully developed photoreceptors, suggesting their immature developmental state. These immature rods also exhibit hyperpolarization-activated current (Ih) induced by the activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. When transplanted into the subretinal space of wild type or retinal degeneration mice, GFP-tagged developing rods can integrate into the photoreceptor outer nuclear layer in wild-type mouse retina, and exhibit Ca2+ responses and membrane current comparable to native rod photoreceptors. A proportion of grafted rods develop rhodopsin-positive outer segment-like structures within two weeks after transplantation into the retina of Crx-knockout mice, and produce rectifier outward current and Ih upon membrane depolarization and hyperpolarization. GFP-positive rods derived from induced pluripotent stem (iPS) cells also display similar membrane current Ih as native developing rod photoreceptors, express rod-specific phototransduction genes, and HCN-1 channels. We conclude that Nrl-promoter driven GFP-tagged donor photoreceptors exhibit physiological characteristics of rods and that iPS cell-derived rods in vitro may provide a renewable source for cell replacement therapy. PMID:23495178

A power-balance model for local helicity injection startup in a spherical tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barr, Jayson L.; Bongard, Michael W.; Burke, Marcus G.

A 0D circuit model for predicting I p( t) in Local Helicity Injection (LHI) discharges is developed. Analytic formulas for estimating the surface flux of finite-A plasmas developed are modified and expanded to treat highly shaped, ultralow-A tokamak geometry using a database of representative equilibria. Model predictions are compared to sample LHI discharges in the A ~ 1 Pegasus spherical tokamak, and are found to agree within 15% of experimental I p( t). High performance LHI discharges are found to follow the Taylor relaxation current limit for approximately the first half of the current ramp, or I p ≲ 75more » kA. The second half of the current ramp follows a limit imposed by power-balance as plasmas expand from high- A to ultralow- A. Here, this shape evolution generates a significant drop in external plasma inductance, effectively using the plasma’s initially high inductance to drive the current ramp and provide > 70% of the current drive V-s. Projections using this model indicate the relative influences of higher helicity input rate and injector current on the attainable total plasma current.« less

A power-balance model for local helicity injection startup in a spherical tokamak

DOE PAGES

Barr, Jayson L.; Bongard, Michael W.; Burke, Marcus G.; ...

2018-05-15

A 0D circuit model for predicting I p( t) in Local Helicity Injection (LHI) discharges is developed. Analytic formulas for estimating the surface flux of finite-A plasmas developed are modified and expanded to treat highly shaped, ultralow-A tokamak geometry using a database of representative equilibria. Model predictions are compared to sample LHI discharges in the A ~ 1 Pegasus spherical tokamak, and are found to agree within 15% of experimental I p( t). High performance LHI discharges are found to follow the Taylor relaxation current limit for approximately the first half of the current ramp, or I p ≲ 75more » kA. The second half of the current ramp follows a limit imposed by power-balance as plasmas expand from high- A to ultralow- A. Here, this shape evolution generates a significant drop in external plasma inductance, effectively using the plasma’s initially high inductance to drive the current ramp and provide > 70% of the current drive V-s. Projections using this model indicate the relative influences of higher helicity input rate and injector current on the attainable total plasma current.« less

The influence of maternal drinking and drug use on the quality of the home environment of school-aged children.

PubMed

Jester, J M; Jacobson, S W; Sokol, R J; Tuttle, B S; Jacobson, J L

2000-08-01

Although many studies have examined the development of children of male alcoholics, few studies have considered substance use by the female caregiver. This study evaluated the relationship between substance use by female caregivers and factors that affect the child-rearing environment. A total of 480 inner-city African-American women were recruited during pregnancy for a longitudinal study of the effects of prenatal alcohol use and substance use by caregivers on the development of their children. All women were screened for alcohol consumption at their first prenatal visit to a large urban maternity hospital. Those who averaged seven or more drinks per week (0.5 oz absolute alcohol per day) at the time of conception were invited to participate in the study, as was a 5% random sample of lighter drinkers and abstainers. At the 7.5-year follow-up assessment, the quantity and frequency of alcohol consumption and drug use, as well as several measures of the child-rearing environment, were assessed for 231 of the caregivers. Current alcohol use was uncorrelated with standard demographic factors, such as socioeconomic status, but was related to poorer family functioning, lower quality of parental intellectual stimulation, and higher levels of domestic violence. There were independent effects of illicit drug use on family environment, domestic violence, and caregiver depression. History of drinking during pregnancy, however, was not related to the current child-rearing environment. Poorer parental functioning generally was found only among the caregivers who currently drank both heavily (six or more drinks/occasion) and frequently (three or more days/week). After controlling for lifetime alcohol problems, current drinking still predicted a less cohesive and organized family environment and higher levels of domestic violence. Current heavy, frequent drinking in this relatively homogenous, economically disadvantaged sample was unrelated to demographics and seemed to have an important negative impact on the quality of the child-rearing environment, whereas drinking during pregnancy was unrelated to the current child-rearing environment.

Modeling of Optical Waveguide Poling and Thermally Stimulated Discharge (TSD) Charge and Current Densities for Guest/Host Electro Optic Polymers

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Ashley, Paul R.; Abushagur, Mustafa

2004-01-01

A charge density and current density model of a waveguide system has been developed to explore the effects of electric field electrode poling. An optical waveguide may be modeled during poling by considering the dielectric charge distribution, polarization charge distribution, and conduction charge generated by the poling field. These charge distributions are the source of poling current densities. The model shows that boundary charge current density and polarization current density are the major source of currents measured during poling and thermally stimulated discharge These charge distributions provide insight into the poling mechanisms and are directly related to E(sub A), and, alpha(sub r). Initial comparisons with experimental data show excellent correlation to the model results.

High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn's Disease.

PubMed

Beaugerie, Laurent; Carrat, Fabrice; Nahon, Stéphane; Zeitoun, Jean-David; Sabaté, Jean-Marc; Peyrin-Biroulet, Laurent; Colombel, Jean-Frédéric; Allez, Matthieu; Fléjou, Jean-François; Kirchgesner, Julien; Svrcek, Magali

2018-06-01

Little is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn's disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn's perianal disease followed up in the Cancers Et Surrisque Associé aux Maladies Inflammatoires Intestinales En France (CESAME) cohort. We collected data from 19,486 patients with inflammatory bowel disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14.9% of participants had past or current anal and/or perianal Crohn's disease. Subjects were followed up for a median time of 35 months (interquartile range, 29-40 mo). To identify risk factors for anal cancer in the total CESAME population, we performed a case-control study in which participants were matched for age and sex. Among the total IBD population, 8 patients developed anal cancer and 14 patients developed rectal cancer. In the subgroup of 2911 patients with past or current anal and/or perianal Crohn's lesions at cohort entry, 2 developed anal squamous-cell carcinoma, 3 developed perianal fistula-related adenocarcinoma, and 6 developed rectal cancer. The corresponding incidence rates were 0.26 per 1000 patient-years for anal squamous-cell carcinoma, 0.38 per 1000 patient-years for perianal fistula-related adenocarcinoma, and 0.77 per 1000 patient-years for rectal cancer. Among the 16,575 patients with ulcerative colitis or Crohn's disease without anal or perianal lesions, the incidence rate of anal cancer was 0.08 per 1000 patient-years and of rectal cancer was 0.21 per 1000 patient-years. Among factors tested by univariate conditional regression (IBD subtype, disease duration, exposure to immune-suppressive therapy, presence of past or current anal and/or perianal lesions), the presence of past or current anal and/or perianal lesions at cohort entry was the only factor significantly associated with development of anal cancer (odds ratio, 11.2; 95% CI, 1.18-551.51; P = .03). In an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn's disease have a high risk of anal cancer, including perianal fistula-related cancer, and a high risk of rectal cancer. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

The O+ contribution and role on the ring current pressure development for CMEs and CIRs using Van Allen Probes observations

NASA Astrophysics Data System (ADS)

Mouikis, C.; Bingham, S.; Kistler, L. M.; Farrugia, C. J.; Spence, H. E.; Gkioulidou, M.

2016-12-01

The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CME's), co-rotating interaction regions (CIR's), high-speed streamers and other structures. The resulting changes in the ring current particle pressure change the global magnetic field, which affects the transport of the radiation belts. In order to determine the field changes during a storm, it is necessary to understand the transport, sources and losses of the particles that contribute to the ring current. The source population of the storm time ring current is the night side plasma sheet. We use Van Allen Probes observations to determine the ring current pressure contribution of the convecting plasma sheet H+ and O+ particles in the storm time development of the ring current. We compare storms that are related to different interplanetary drivers, CMEs and CIRs, as observed at different local times. We find that during the storm main phase most of the ring current pressure in the pre-midnight inner magnetosphere is contributed by particles on open drift paths that cause the development of a strong partial ring current that causes most of the main phase Dst drop. These particles can reach as deep as L 2 and their pressure compares to the local magnetic field pressure as deep as L 3. During the recovery phase, if these particles are not lost at the magnetopause, will become trapped and will contribute to the symmetric ring current. However, the largest difference between the CME and CIR ring current responses during the storm main and early recovery phases is caused by how the 15 - 60 keV O+ responds to these drivers.

Israel: Background and U.S. Relations

DTIC Science & Technology

2012-02-29

security goals and have developed close relations based on common perceptions of shared democratic values and religious affinities. U.S. policymakers...and Christian religious claims in the city. Although Israel withdrew its permanent military presence from the Gaza Strip in 2005, it still controls...trends partly explain why Israel’s current Jewish population is “more nationalistic, religiously conservative, and hawkish on foreign policy and

Knowledge, Beliefs and Behaviours Related to STD Risk, Prevention, and Screening among a Sample of African American Men and Women

ERIC Educational Resources Information Center

Uhrig, Jennifer D.; Friedman, Allison; Poehlman, Jon; Scales, Monica; Forsythe, Ann

2014-01-01

Objective: Current data on sexually transmitted disease (STD) among African Americans show significant racial/ethnic disparities. The purpose of this study was to explore knowledge, attitudes, beliefs, and behaviours related to STD risk, prevention, and testing among African American adults to help inform the development of a health communication…

Experimental program to stimulate competitive energy research in North Dakota: Summary and significance of DOE Trainee research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boudjouk, Philip

1999-07-01

The general goals of the North Dakota DOE/EPSCoR Program are to enhance the capabilities of North Dakota's researchers to conduct nationally competitive energy-related research and to develop science and engineering human resources to meet current and future needs in energy-related areas. Doctoral students were trained and energy research was conducted.

Attitudes among Vietnamese Educators towards Students with Disabilities and Their Implications Relative to Inclusive Practices: The Findings of a Preliminary Investigation

ERIC Educational Resources Information Center

Austin, Vance L.

2011-01-01

This article presents the findings of a short-term quantitative/qualitative study concerning the attitudes of Vietnamese educators towards individuals with disabilities and its possible implications relative to the development of inclusion and special education in Vietnam. The current conditions regarding the education of students with and without…

Ages and Career Stages: Considerations in Providing Support for Mid-Late Career Stage Doctoral Students

ERIC Educational Resources Information Center

Robertson, Margaret J.

2017-01-01

This article raises two inter-related issues: firstly there is a correlation between the needs of doctoral students that are strongly related to age and career stage; and secondly, because these needs differ according to their demographic, the current discourse of developing work-readiness skills of doctoral students is misplaced for the growing…

Worker Generated Issues, Critical Dialogue, and Praxis: A Freirean Approach to Developing Social Change Projects

ERIC Educational Resources Information Center

O'Brien, Tim

2009-01-01

The escalating crisis in capitalist relations around the world demands a variety of responses that unmask the confusing structures that perpetuate asymmetrical power relations, while reframing what is truly in the interests of the majority of people. Industrial unions in the U.S. have at times aspired to such an advocacy role, but currently offer…

Reviews of Data on Science Resources, No. 29. Current and Future Utilization of Scientific and Technical Personnel in Energy-Related Activities.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Div. of Science Resources Studies.

This National Science Foundation (NSF) bulletin summarizes the NSF program of energy manpower studies that assessed the impact of past energy developments and future options for scientific and technical manpower. This document summarizes the utilization of scientific personnel in energy-related activities in private industry in 1975 and shortages…

Securing World-Class Research in UK Universities: Exploring the Impact of Block Grant Funding

ERIC Educational Resources Information Center

Universities UK, 2009

2009-01-01

The UK research base is world class. It is second only to the USA on leading scientific indicators and crucially, during the current economic climate, ranks first on publication productivity and citations in relation to research and development public spend. Commonly known as quality-related (QR) funding because it is allocated selectively on the…

Current Space Projects of the Bolivarian Republic of Venezuela

NASA Astrophysics Data System (ADS)

Hernández, R.; Acevedo R.; Varela, F.; Otero, S.

2014-06-01

Since 2008, with the successful launch of the first Venezuelan telecommunication satellite VENESAT-1, the Bolivarian Republic of Venezuela became an active player in the international space sector aimed at using space science and technology as a powerful tool to promote the national development. Based on that, through the Bolivarian Agency for Space Activities (ABAE), Venezuela has been implemented several space projects such as the manufacturing and launch of the first Venezuelan remote sensing satellite, the construction of a design center for small satellite technologies, as well as research and development activities related with the estimation of the physical properties of the Earth. This paper presents a brief description of the current space projects that are being developed by Venezuela.

[Clinical toxicology of the Academy: yesterday, today and tomorrow].

PubMed

Sofronov, G A; Khalimov, Iu Sh; Matveev, S Iu; Kuz'mich, V G; Fomichev, A V

2013-12-01

National toxicology school of the Kirov Military Medical Academy, demonstrates the unity of clinical and experimental approaches related to one purpose throughout its history--saving human life and health from exposure to toxic substances of chemical nature. For more than three centuries the russian science of toxicology has been steadily developing, often ahead of the world science. It helped to create the means of protection and develop methods of treatment for chemical lesions. Currently, toxicology departments of military field therapy and military toxicology and medical protection are actively involved in the current study of military medicine, restructuring policy to provide toxicological aid in the Armed Forces, the development and introduction of Innovative methods of diagnosis and treatment of victims of toxicological etiology.

Fiber-optic sensors for aerospace electrical measurements - An update

NASA Technical Reports Server (NTRS)

Patterson, Richard L.; Rose, A. H.; Tang, D.; Day, G. W.

1991-01-01

The authors report the progress made on the development of aerospace current and voltage sensors which use fiber-optic and optical sensing heads. These sensors are presently designed to cover ac frequencies from 60 Hz to 20 kHz. The current sensor, based on the Faraday effect in optical fiber, is in advanced development after some initial testing. The emphasis is on packaging methods and ways to maintain consistent sensitivity with changes in temperature. The voltage sensor, utilizing the Pockels effect in a crystal, has excelled in temperature tests. The authors report on the development of these sensors. The authors also relate the technology used in the sensors, the results of evaluation, improvements being made, and the future direction of the work.

A three-dimensional stratigraphic model for aggrading submarine channels based on laboratory experiments, numerical modeling, and sediment cores

NASA Astrophysics Data System (ADS)

Limaye, A. B.; Komatsu, Y.; Suzuki, K.; Paola, C.

2017-12-01

Turbidity currents deliver clastic sediment from continental margins to the deep ocean, and are the main driver of landscape and stratigraphic evolution in many low-relief, submarine environments. The sedimentary architecture of turbidites—including the spatial organization of coarse and fine sediments—is closely related to the aggradation, scour, and lateral shifting of channels. Seismic stratigraphy indicates that submarine, meandering channels often aggrade rapidly relative to lateral shifting, and develop channel sand bodies with high vertical connectivity. In comparison, the stratigraphic architecture developed by submarine, braided is relatively uncertain. We present a new stratigraphic model for submarine braided channels that integrates predictions from laboratory experiments and flow modeling with constraints from sediment cores. In the laboratory experiments, a saline density current developed subaqueous channels in plastic sediment. The channels aggraded to form a deposit with a vertical scale of approximately five channel depths. We collected topography data during aggradation to (1) establish relative stratigraphic age, and (2) estimate the sorting patterns of a hypothetical grain size distribution. We applied a numerical flow model to each topographic surface and used modeled flow depth as a proxy for relative grain size. We then conditioned the resulting stratigraphic model to observed grain size distributions using sediment core data from the Nankai Trough, offshore Japan. Using this stratigraphic model, we establish new, quantitative predictions for the two- and three-dimensional connectivity of coarse sediment as a function of fine-sediment fraction. Using this case study as an example, we will highlight outstanding challenges in relating the evolution of low-relief landscapes to the stratigraphic record.

Adaptive Variable Bias Magnetic Bearing Control

NASA Technical Reports Server (NTRS)

Johnson, Dexter; Brown, Gerald V.; Inman, Daniel J.

1998-01-01

Most magnetic bearing control schemes use a bias current with a superimposed control current to linearize the relationship between the control current and the force it delivers. With the existence of the bias current, even in no load conditions, there is always some power consumption. In aerospace applications, power consumption becomes an important concern. In response to this concern, an alternative magnetic bearing control method, called Adaptive Variable Bias Control (AVBC), has been developed and its performance examined. The AVBC operates primarily as a proportional-derivative controller with a relatively slow, bias current dependent, time-varying gain. The AVBC is shown to reduce electrical power loss, be nominally stable, and provide control performance similar to conventional bias control. Analytical, computer simulation, and experimental results are presented in this paper.

Dance for Individuals With Dementia.

PubMed

Lapum, Jennifer L; Bar, Rachel J

2016-03-01

The movement and music associated with dance plays an important role in many individuals' lives and can become imprinted upon the body and mind. Dance is thus closely associated with memory because of these deep connections. Without conscious thought, dance has the potential to be initiated as individuals age. In the current article, the authors share narrative reflections about their experiences with, and the potential of, dance as an intervention for aging populations diagnosed with dementia-related diseases. They draw upon their experiences in working with the aging population and a dance program currently being developed by Canada's National Ballet School and Baycrest Health Sciences for individuals with dementia-related diseases in long-term care. The current article is structured as dialogue between the authors because it mimics dance as a dialogical encounter between movement and music, and/or between individuals. Copyright 2016, SLACK Incorporated.

A review of nondestructive examination technology for polyethylene pipe in nuclear power plant

NASA Astrophysics Data System (ADS)

Zheng, Jinyang; Zhang, Yue; Hou, Dongsheng; Qin, Yinkang; Guo, Weican; Zhang, Chuck; Shi, Jianfeng

2018-05-01

Polyethylene (PE) pipe, particularly high-density polyethylene (HDPE) pipe, has been successfully utilized to transport cooling water for both non-safety- and safety-related applications in nuclear power plant (NPP). Though ASME Code Case N755, which is the first code case related to NPP HDPE pipe, requires a thorough nondestructive examination (NDE) of HDPE joints. However, no executable regulations presently exist because of the lack of a feasible NDE technique for HDPE pipe in NPP. This work presents a review of current developments in NDE technology for both HDPE pipe in NPP with a diameter of less than 400 mm and that of a larger size. For the former category, phased array ultrasonic technique is proven effective for inspecting typical defects in HDPE pipe, and is thus used in Chinese national standards GB/T 29460 and GB/T 29461. A defect-recognition technique is developed based on pattern recognition, and a safety assessment principle is summarized from the database of destructive testing. On the other hand, recent research and practical studies reveal that in current ultrasonic-inspection technology, the absence of effective ultrasonic inspection for large size was lack of consideration of the viscoelasticity effect of PE on acoustic wave propagation in current ultrasonic inspection technology. Furthermore, main technical problems were analyzed in the paper to achieve an effective ultrasonic test method in accordance to the safety and efficiency requirements of related regulations and standards. Finally, the development trend and challenges of NDE test technology for HDPE in NPP are discussed.

Advanced Ultrafast Spectroscopy for Chemical Detection of Nuclear Fuel Cycle Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Villa-Aleman, E.; Houk, A.; Spencer, W.

The development of new signatures and observables from processes related to proliferation activities are often related to the development of technologies. In our physical world, the intensity of observables is linearly related to the input drivers (light, current, voltage, etc.). Ultrafast lasers with high peak energies, opens the door to a new regime where the intensity of the observables is not necessarily linear with the laser energy. Potential nonlinear spectroscopic applications include chemical detection via remote sensing through filament generation, material characterization and processing, chemical reaction specificity, surface phenomena modifications, X-ray production, nuclear fusion, etc. The National Security Directorate lasermore » laboratory is currently working to develop new tools for nonproliferation research with femtosecond and picosecond lasers. Prior to this project, we could only achieve laser energies in the 5 nano-Joule range, preventing the study of nonlinear phenomena. To advance our nonproliferation research into the nonlinear regime we require laser pulses in the milli-Joule (mJ) energy range. We have procured and installed a 35 fs-7 mJ laser, operating at one-kilohertz repetition rate, to investigate elemental and molecular detection of materials in the laboratory with potential applications in remote sensing. Advanced, nonlinear Raman techniques will be used to study materials of interest that are in a matrix of many materials and currently with these nonlinear techniques we can achieve greater than three orders of magnitude signal enhancement. This work studying nuclear fuel cycle materials with nonlinear spectroscopies will advance SRNL research capabilities and grow a core capability within the DOE complex.« less

Determining the maximum charging currents of lithium-ion cells for small charge quantities

NASA Astrophysics Data System (ADS)

Grimsmann, F.; Gerbert, T.; Brauchle, F.; Gruhle, A.; Parisi, J.; Knipper, M.

2017-10-01

In order to optimize the operating parameters of battery management systems for electric and hybrid vehicles, great interest has been shown in achieving the maximum permissible charging currents during recuperation, without causing a cell damage due to lithium plating, in relation to the temperature, charge quantity and state of charge. One method for determining these recuperation currents is measuring the cell thickness, where excessively high charging currents can be detected by an irreversible increase in thickness. It is not possible to measure particularly small charge quantities by employing mechanic dial indicators, which have a limited resolution of 1 μm. This is why we developed a measuring setup that has a resolution limit of less than 10 nm using a high-resolution contactless inductance sensor. Our results show that the permissible charging current I can be approximated in relation to the charge quantity x by a correlating function I =a /√{(x) } which is compliant with the Arrhenius law. Small charge quantities therefore have an optimization potential for energy recovery during recuperation.

[Current State of Studies on Job-related Stress among Psychiatric Social Workers and Insights into Future Research].

PubMed

Yada, Hironori; Abe, Hiroshi; Odachi, Ryo; Iwanaga, Yasushi; Yamane, Toshie

2016-01-01

We studied the characteristics of psychiatric social workers (PSWs) and present research on job-related stress among them; we also provide insights into the future of such research. In recent years, studies on job-related stress among PSWs have been gaining interest. In particular, stress associated with the repeated revisions of related laws has increased. Subsequently, it was found that occupational stress in PSWs differs qualitatively and quantitatively depending on educational history, years of experience, and service department. However, no scale captures the specific characteristics of job-related stress among PSWs. Moreover, the development of a mental health care program for PSWs seems difficult. To develop a mental health care program that caters specifically to this group, future research should focus on developing a scale that determines the specific characteristics of job-related stress among PSWs, which should be evaluated on the basis of each PSW's educational history, years of experience, and service department.

Advanced Turbofan Duct Liner Concepts

NASA Technical Reports Server (NTRS)

Bielak, Gerald W.; Premo, John W.; Hersh, Alan S.

1999-01-01

The Advanced Subsonic Technology Noise Reduction Program goal is to reduce aircraft noise by 10 EPNdB by the year 2000 relative, to 1992 technology. The improvement goal for nacelle attenuation is 25% relative to 1992 technology by 1997 and 50% by 2000. The Advanced Turbofan Duct Liner Concepts Task work by Boeing presented in this document was in support of these goals. The basis for the technical approach was a Boeing study conducted in 1993-94 under NASA/FAA contract NAS1-19349, Task 6, investigating broadband acoustic liner concepts. As a result of this work, it was recommended that linear double layer, linear and perforate triple layer, parallel element, and bulk absorber liners be further investigated to improve nacelle attenuations. NASA LaRC also suggested that "adaptive" liner concepts that would allow "in-situ" acoustic impedance control also be considered. As a result, bias flow and high-temperature liner concepts were also added to the investigation. The major conclusion from the above studies is that improvements in nacelle liner average acoustic impedance characteristics alone will not result in 25% increased nacelle noise reduction relative to 1992 technology. Nacelle design advancements currently being developed by Boeing are expected to add 20-40% more acoustic lining to hardwall regions in current inlets, which is predicted to result in and additional 40-80% attenuation improvement. Similar advancements are expected to allow 10-30% more acoustic lining in current fan ducts with 10-30% more attenuation expected. In addition, Boeing is currently developing a scarf inlet concept which is expected to give an additional 40-80% attenuation improvement for equivalent lining areas.

The Development of a Leadership Self-Efficacy Measure

DTIC Science & Technology

2010-03-01

motivation to regulate current behaviors” (Hannah el al., 2008: 677). This self-motivation efficacy has been an    14    important part of many...to become a source of motivation to regulate current behaviors (Hannah el al., 2008: 677). The second factor contained the following items...priorities are 20. Understanding what he/she is expected to do 21. Taking charge at appropriate times 22. Supporting human relations and EEOC programs 23

An important role of the moisture supply from the Kuroshio Current/Kuroshio Extension in the rapid development of an explosive cyclone

NASA Astrophysics Data System (ADS)

Hirata, H.; Kawamura, R.; Kato, M.; Shinoda, T.

2014-12-01

We investigated how the moisture supply from the Kuroshio Current/Kuroshio Extension affects the rapid intensification of an explosive cyclone using a couple atmosphere-ocean non-hydrostatic model, CReSS-NHOES. The Cloud-Resolving Storm Simulator (CReSS) and the Non-Hydrostatic Ocean model for the Earth Simulator (NHOES) have been developed by the Hydrospheric Atmospheric Research Center of Nagoya University and the Japan Agency for Marine-Earth Science and Technology, respectively. We performed a numerical simulation of an extratropical cyclone migrating along the southern periphery of the Kuroshio Current on January 14, 2013, that developed most rapidly in recent years in the vicinity of Japan. The evolutions of surface fronts related to the cyclone simulated by the CReSS-NHOES closely resemble Shapiro-Keyser model. In the lower troposphere, the cyclone's bent-back front and the associated frontal T-bone structure become evident with the cyclone development. Cold Conveyor Belt (CCB) is also well organized over the northern part of the cyclone. During its developing stage, since the CCB dominates just over the Kuroshio Current/Kuroshio Extension, a large amount of moisture is efficiently supplied from the warm current into the CCB. The vapor evaporated from the underlying warm current is transported into the bent-back front by the CCB and converges horizontally in the vicinity of the front. As a result, strong diabatic heating arises over the corresponding moisture convergence area in that vicinity, indicating that the abundant moisture due to the warm current plays a vital role in rapid development of the cyclone through latent heat release processes. Both processes of the moisture transport from the warm current into the cyclone system via the CCB and of the latent heat release around the bent-back front are also confirmed by trajectory analyses. The rapid SLP decrease of the cyclone center can in turn increase the moisture supply from the warm current through enhancement of the CCB. We anticipate that such a feedback process plays a key role in the rapid intensification of the cyclone highlighted in this study.

Emerging Drugs for the Treatment of Symptoms Associated with Autism Spectrum Disorders

PubMed Central

Wink, Logan K.; Plawecki, Martin H.; Erickson, Craig A.; Stigler, Kimberly A.; McDougle, Christopher J.

2010-01-01

Importance of the Field Autism spectrum disorders, or pervasive developmental disorders (PDDs), are neurodevelopmental disorders defined by qualitative impairment in social interaction, impaired communication, and stereotyped patterns of behavior. The most common forms of PDD are autstic disorder (autism), Asperger's disorder, and pervasive developmental disorder not otherwise specified (PDD NOS). Recent surveillance studies reveal an increase in the prevalence of autism and related PDDs. The use of pharmacologic agents in the treatment of these disorders can reduce the impact of interfering symptoms, providing relief for affected individuals and their families. Areas Covered in this Review This review examines results from neurobiologic research in an attempt to both elucidate the pathophysiology of autism and guide the development of pharmacologic agents for the treatment of associated symptoms. The safety and efficacy data of drugs currently in clinical use for the treatment of these symptoms, as well as pharmaceuticals currently under development, are discussed. What the Reader will Gain This comprehensive review will deepen the reader's current understanding of the research guiding the pharmacologic treatment of symptoms associated with autism and related PDDs. Areas of focus for future research are also discussed. The need for large-scale investigation of some commonly used pharmacologic agents, in addition to the development of drugs with improved efficacy and safety profiles, is made evident. Take Home Message Despite progress in the development of pharmacologic treatments for a number of interfering symptom domains associated with autism and other PDDs, a great deal of work remains. PMID:20470188

Multi-Modal Traveler Information System - Alternative GCM Corridor Technologies and Strategies

DOT National Transportation Integrated Search

1997-10-24

The purpose of this working paper is to summarize current and evolving Intelligent Transportation System (ITS) technologies and strategies related to the design, development, and deployment of regional multi-modal traveler information systems. This r...

Tower-Related Major System Development Programs

DOT National Transportation Integrated Search

1978-03-01

This report is devoted to the present and near future states of the tower cab environment, addresses those MSDP systems which may have an impact on the current tower cab environment, systems and/or operations. The systems included are: Discrete Addre...

JPRS Report, Arms Control

DTIC Science & Technology

1989-12-01

the current crisis." [passage omitted] In related developments, Presidential Chief-of-Staff Alberto Kohan disclosed yesterday that the Soviet gov...1989 The ABIMDE leaders, with four-star General Diogo Figueiredo, the youngest brother of former president Joao Figueiredo, in attendance, decided

Computations of Vertical Displacement Events with Toroidal Asymmetry

NASA Astrophysics Data System (ADS)

Sovinec, C. R.; Bunkers, K. J.

2017-10-01

Nonlinear numerical MHD modeling with the NIMROD code [https://nimrodteam.org] is being developed to investigate asymmetry during vertical displacement events. We start from idealized up/down symmetric tokamak equilibria with small levels of imposed toroidally asymmetric field errors. Vertical displacement results when removing current from one of the two divertor coils. The Eulerian reference-frame modeling uses temperature-dependent resistivity and anisotropic thermal conduction to distinguish the hot plasma region from surrounding cold, low-density conditions. Diffusion through a resistive wall is slow relative to Alfvenic scales but much faster than resistive plasma diffusion. Loss of the initial edge pressure and current distributions leads to a narrow layer of parallel current, which drives low-n modes that may be related to peeling-dominated ELMs. These modes induce toroidal asymmetry in the conduction current, which connects the simulated plasma to the wall. Work supported by the US DOE through Grant Numbers DE-FG02-06ER54850 and DE-FC02-08ER54975.

Social leverage of intellectual property: road to the development of better therapy for tuberculosis.

PubMed

Thangaraj, Harry; Reljic, Rajko

2009-06-01

Current TB drug development is beset with many problems. There is a perceived lack of commercial return on investment, as the vast majority of TB patients come from impoverished areas of the world. Clinical trials for new TB drugs are complex, protracted and very expensive. Therefore, the development of new anti-tuberculosis drugs requires simultaneous forward planning of the design of the trials that will be required for licensing purposes. In this article we briefly review the current state of new TB drug development and discuss issues related to intellectual property (IP), with a special emphasis on how IP can facilitate rather than hinder the development of better TB drugs. We also list and discuss the major patent applications that underpin TB drugs that have entered prominent clinical trials and additional applications that were filed over the last five years for drugs resulting from basic upstream research.

NASA's Quiet Aircraft Technology Project

NASA Technical Reports Server (NTRS)

Whitfield, Charlotte E.

2004-01-01

NASA's Quiet Aircraft Technology Project is developing physics-based understanding, models and concepts to discover and realize technology that will, when implemented, achieve the goals of a reduction of one-half in perceived community noise (relative to 1997) by 2007 and a further one-half in the far term. Noise sources generated by both the engine and the airframe are considered, and the effects of engine/airframe integration are accounted for through the propulsion airframe aeroacoustics element. Assessments of the contribution of individual source noise reductions to the reduction in community noise are developed to guide the work and the development of new tools for evaluation of unconventional aircraft is underway. Life in the real world is taken into account with the development of more accurate airport noise models and flight guidance methodology, and in addition, technology is being developed that will further reduce interior noise at current weight levels or enable the use of lighter-weight structures at current noise levels.

Current and future perspectives on the development ...

EPA Pesticide Factsheets

Safety-related problems continue to be one of the major reasons of attrition in drug development. Non-testing approaches to predict toxicity could form part of the solution. This review provides a perspective of current status of non-testing approaches available for the prediction of different toxicity endpoints. A framework for the development, evaluation and assessment of (Q)SARs is presented together with several examples. A workflow for performing read-across predictions within category and analogue approaches is presented and the shortcomings discussed. In light of the advances in high throughput (HT) approaches and constructs such as adverse outcome pathways (AOPs) coming on-line to help in interpreting such HT data, the ways in which non-testing approaches are developed are also evolving. We discuss what the future of these approaches might look like and outline how their integration could be useful in screening toxicity for drug development. Invited review article for CRT for a special issue.

Cash transfers for HIV prevention: considering their potential.

PubMed

Heise, Lori; Lutz, Brian; Ranganathan, Meghna; Watts, Charlotte

2013-08-23

Cash payments to vulnerable households and/or individuals have increasingly garnered attention as a means to reduce poverty, improve health and achieve other development-related outcomes. Recent evidence from Malawi and Tanzania suggests that cash transfers can impact HIV-related behaviours and outcomes and, therefore, could serve as an important addition to HIV prevention efforts. This article reviews the current evidence on cash transfers for HIV prevention and suggests unresolved questions for further research. Gaps include (1) understanding more about the mechanisms and pathways through which cash transfers affect HIV-related outcomes; (2) addressing key operational questions, including the potential feasibility and the costs and benefits of different models of transfers and conditionality; and (3) evaluating and enhancing the wider impacts of cash transfers on health and development. Ongoing and future studies should build on current findings to unpack unresolved questions and to collect additional evidence on the multiple impacts of transfers in different settings. Furthermore, in order to address questions on sustainability, cash transfer programmes need to be integrated with other sectors and programmes that address structural factors such as education and programming to promote gender equality and address HIV.

[Asthma--a condition of our time, a condition in change?].

PubMed

Carlsen, K H

2001-03-10

This article reviews causative factors for asthma and allergy during childhood and describes current trends in prevalence and hospitalisation for childhood asthma. A review of the prevalence of childhood asthma in Norway over the last 50 years together with recent trends in hospitalisation for childhood asthma, is given. Possible causative factors for childhood asthma are reviewed, and recent theories for the current increase in prevalence are discussed. During the last 50 years, a steady increase in the prevalence of childhood asthma has been documented through published studies from 1948 and onwards. From 1980 and until 1990, an increase in hospital admissions due to acute asthma was observed; later, admissions have leveled off, particularly as regards readmissions. Smoking during pregnancy and childhood decreases lung function. Allergic sensitisation is related to asthma development and may occur already during pregnancy. Increased allergic sensitisation may occur due to reduced load of infections. However, respiratory virus infections, and especially RS virus and rhinovirus infections, are closely related to asthma development and symptoms during childhood. A reduction in readmissions for asthma may be related to increased use of antiinflammatory therapy for asthma.

Biomarkers and Surrogate Endpoints in Uveitis: The Impact of Quantitative Imaging.

PubMed

Denniston, Alastair K; Keane, Pearse A; Srivastava, Sunil K

2017-05-01

Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis and measurement algorithms across both standard and emerging imaging modalities, can develop objective instrument-based measures of disease activity. This is a narrative review based on searches of the current world literature using terms related to quantitative imaging techniques in uveitis, supplemented by clinical trial registry data, and expert knowledge of surrogate endpoints and outcome measures in ophthalmology. Current measures of disease activity are largely based on subjective clinical estimation, and are relatively insensitive, with poor discrimination and reliability. The development of quantitative imaging in uveitis is most established in the use of optical coherence tomographic (OCT) measurement of central macular thickness (CMT) to measure severity of macular edema (ME). The transformative effect of CMT in clinical assessment of patients with ME provides a paradigm for the development and impact of other forms of quantitative imaging. Quantitative imaging approaches are now being developed and validated for other key inflammatory parameters such as anterior chamber cells, vitreous haze, retinovascular leakage, and chorioretinal infiltrates. As new forms of quantitative imaging in uveitis are proposed, the uveitis community will need to evaluate these tools against the current subjective clinical estimates and reach a new consensus for how disease activity in uveitis should be measured. The development, validation, and adoption of sensitive and discriminatory measures of disease activity is an unmet need that has the potential to transform both drug development and routine clinical care for the patient with uveitis.

Cilia/Ift protein and motor -related bone diseases and mouse models.

PubMed

Yuan, Xue; Yang, Shuying

2015-01-01

Primary cilia are essential cellular organelles projecting from the cell surface to sense and transduce developmental signaling. They are tiny but have complicated structures containing microtubule (MT)-based internal structures (the axoneme) and mother centriole formed basal body. Intraflagellar transport (Ift) operated by Ift proteins and motors are indispensable for cilia formation and function. Mutations in Ift proteins or Ift motors cause various human diseases, some of which have severe bone defects. Over the last few decades, major advances have occurred in understanding the roles of these proteins and cilia in bone development and remodeling by examining cilia/Ift protein-related human diseases and establishing mouse transgenic models. In this review, we describe current advances in the understanding of the cilia/Ift structure and function. We further summarize cilia/Ift-related human diseases and current mouse models with an emphasis on bone-related phenotypes, cilia morphology, and signaling pathways.

Recalled peer relationship experiences and current levels of self-criticism and self-reassurance.

PubMed

Kopala-Sibley, Daniel C; Zuroff, David C; Leybman, Michelle J; Hope, Nora

2013-03-01

Numerous studies have shown that personality factors may increase or decrease individuals' vulnerability to depression, but little research has examined the role of peer relationships in the development of these factors. Accordingly, this study examined the role of recalled parenting and peer experiences in the development of self-criticism and self-reassurance. It was hypothesized that, controlling for recalled parenting behaviours, specific recalled experiences of peer relationships would be related to current levels of specific forms of self-criticism and self-reassurance. Hypotheses were tested using a retrospective design in which participants were asked to recall experiences of parenting and peer relationships during early adolescence. This age was chosen as early adolescence has been shown to be a critical time for the development of vulnerability to depression. A total of 103 female and 97 male young adults completed measures of recalled parenting, overt and relational victimization and prosocial behaviour by peers, and current levels of self-criticism and self-reassurance. Hierarchical regression analyses showed that parents and peers independently contributed to the development of self-criticism and self-reassurance. Specifically, controlling for parental care and control, overt victimization predicted self-hating self-criticism, relational victimization predicted inadequacy self-criticism, and prosocial behaviour predicted self-reassurance. As well, prosocial behaviour buffered the effect of overt victimization on self-reassurance. Findings highlight the importance of peers in the development of personality risk and resiliency factors for depression, and suggest avenues for interventions to prevent the development of depressive vulnerabilities in youth. The nature of a patient's personality vulnerability to depression may be better understood through a consideration of the patient's relationships with their peers as well as with parents during adolescence. An understanding of adult patients' past peer relationships may further the therapist's understanding of the client's core schemas and dysfunctional attitudes, as well as potential transference reactions during therapy. Identifying and helping youth to better cope with peer victimization may help prevent the development of a vulnerable personality style in adulthood. Fostering positive peer relationships in adolescence may buffer the effects of other more negative relationships with peers. © 2011 The British Psychological Society.

Work-Related Injury Surveillance in Vietnam: A National Reporting System Model

PubMed Central

Marucci-Wellman, Helen; Wegman, David H.; Leamon, Tom B.; Tuyet Binh, Ta Thi; Diep, Nguyen Bich; Kriebel, David

2013-01-01

Developing nations bear a substantial portion of the global burden of injury. Public health surveillance models in developing countries should recognize injury risks for all levels of society and all causes and should incorporate various groups of workers and industries, including subsistence agriculture. However, many developing nations do not have an injury registration system; current data collection methods result in gross national undercounts of injuries, failing to distinguish injuries that occur during work. In 2006, we established an active surveillance system in Vietnam’s Xuan Tien commune and investigated potential methods for surveillance of work-related injuries. On the basis of our findings, we recommend a national model for work-related injury surveillance in Vietnam that builds on the existing health surveillance system. PMID:24028255

Integration of the Total Lightning Jump Algorithm into Current Operational Warning Environment Conceptual Models

NASA Technical Reports Server (NTRS)

Shultz, Christopher J.; Carey, Lawrence D.; Schultz, Elise V.; Stano, Geoffrey T.; Blakeslee, Richard J.; Goodman, Steven J.

2014-01-01

The presence and rates of total lightning are both correlated to and physically dependent upon storm updraft strength, mixed phase precipitation volume and the size of the charging zone. The updraft modulates the ingredients necessary for electrification within a thunderstorm, while the updraft also plays a critical role in the development of severe and hazardous weather. Therefore utilizing this relationship, the monitoring of lightning rates and jumps provides an additional piece of information on the evolution of a thunderstorm, more often than not, at higher temporal resolution than current operational radar systems. This correlation is the basis for the total lightning jump algorithm that has been developed in recent years. Currently, the lightning jump algorithm is being tested in two separate but important efforts. Schultz et al. (2014; AMS 10th Satellite Symposium) is exploring the transition of the algorithm from its research based formulation to a fully objective algorithm that includes storm tracking, Geostationary Lightning Mapper (GLM) Proxy data and the lightning jump algorithm. Chronis et al. (2014; this conference) provides context for the transition to current operational forecasting using lightning mapping array based products. However, what remains is an end to end physical and dynamical basis for relating lightning rates to severe storm manifestation, so the forecaster has a reason beyond simple correlation to utilize the lightning jump algorithm within their severe storm conceptual models. Therefore, the physical basis for the lightning jump algorithm in relation to severe storm dynamics and microphysics is a key component that must be further explored. Many radar studies have examined flash rates and their relation to updraft strength, updraft volume, precipitation-sized ice mass, etc.; however, relation specifically to lightning jumps is fragmented within the literature. Thus the goal of this study is to use multiple Doppler techniques to resolve the physical and dynamical storm characteristics specifically around the time of the lightning jump. This information will help forecasters anticipate lightning jump occurrence, or even be of use to determine future characteristics of a given storm (e.g., development of a mesocyclone, downdraft, or hail signature on radar), providing additional lead time/confidence in the severe storm warning paradigm.

Commercial compact cyclotrons in the 90`s

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference tomore » those demands that differ from those in a research oriented cyclotron project. The authors also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA.« less

Nanotechnology in food processing sector-An assessment of emerging trends.

PubMed

Kalpana Sastry, R; Anshul, Shrivastava; Rao, N H

2013-10-01

Use of nanoscience based technology in the food industry is fast emerging as new area for research and development. Several research groups including private companies in the industry have initiated research programmes for exploring the wide scope of nanotechnology into the value chain of food processing and manufacturing. This paper discusses the current focus of research in this area and assesses its potential impacts. Using the developed relational database framework with R&D indicators like literature and patent documents for assessment of the potential of nanotechnology in food sector, a model to organize and map nanoresearch areas to the food processing sector was developed. The study indicates that the about five basic categories of nanotechnology applications and functionalities currently in the development of food sector, include food processing, packaging, nutraceuticals delivery, food safety and functional foods.

Study of the application of advanced technologies to long-range transport aircraft. Volume 2: Research and development requirements

NASA Technical Reports Server (NTRS)

Lange, R. H.; Sturgeon, R. F.; Adams, W. E.; Bradley, E. S.; Cahill, J. F.; Eudaily, R. R.; Hancock, J. P.; Moore, J. W.

1972-01-01

Investigations were conducted to evaluate the relative benefits attainable through the exploitation of advanced technologies and to identify future research and development efforts required to permit the application of selected technologies to transport aircraft entering commercial operation in 1985. Results show that technology advances, particularly in the areas of composite materials, supercritical aerodynamics, and active control systems, will permit the development of long-range, high-payload commercial transports operating at high-subsonic speeds with direct operating costs lower than those of current aircraft. These advanced transports also achieve lower noise levels and lower engine pollutant emissions than current transports. Research and development efforts, including analytical investigations, laboratory test programs, and flight test programs, are required in essentially all technology areas to achieve the potential technology benefits.

Advances and challenges in malaria vaccine development.

PubMed

Crompton, Peter D; Pierce, Susan K; Miller, Louis H

2010-12-01

Malaria caused by Plasmodium falciparum remains a major public health threat, especially among children and pregnant women in Africa. An effective malaria vaccine would be a valuable tool to reduce the disease burden and could contribute to elimination of malaria in some regions of the world. Current malaria vaccine candidates are directed against human and mosquito stages of the parasite life cycle, but thus far, relatively few proteins have been studied for potential vaccine development. The most advanced vaccine candidate, RTS,S, conferred partial protection against malaria in phase II clinical trials and is currently being evaluated in a phase III trial in Africa. New vaccine targets need to be identified to improve the chances of developing a highly effective malaria vaccine. A better understanding of the mechanisms of naturally acquired immunity to malaria may lead to insights for vaccine development.

The current status, challenges, and future developments of new tuberculosis vaccines.

PubMed

Gong, Wenping; Liang, Yan; Wu, Xueqiong

2018-03-30

Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guérin (BCG), is ineffective for prevention of pulmonary TB in adults. Therefore, it is very important to develop novel vaccines for TB prevention and control. This literature review provides an overview of the innate and adaptive immune response during M. tuberculosis infection, and presents current developments and challenges to novel TB vaccines. A comprehensive understanding of vaccines in preclinical and clinical studies provides extensive insight for the development of safer and more efficient vaccines, and may inspire new ideas for TB prevention and treatment.

Understanding the connection between historic range of variation, current social values and developing desired conditions

Treesearch

Larry Blocker; Susan K. Hagle; Rick Lasko; Robert Keane; Barry Bollenbacher; Bruce Fox; Fred Samson; Randy Gay; Cynthia Manning

2001-01-01

Relationships between the development of desired conditions based on today’s social values, and an understanding of the historic range of variability (HRV) are key to the implementation of ecosystem management. Relevant to the discussion are wildlife habitat values, forage production, economics related to wood resources, aesthetics and visual quality, changes in...

The Bridge between Motivation and Implementation; An inside Look to Professional Development

ERIC Educational Resources Information Center

Sonmez, Duygu; Haury, David

2011-01-01

DNA and DNA related technologies have become a part of daily life in the 21st century. In today's world, it is a necessity for science teachers to keep up with current changes in sciences and be able to teach the content in their classrooms. Such needs in consideration, professional development programs aim to help teachers during the transition…

Case Studies on the Use of Technology in TPD (Teacher Professional Development)

ERIC Educational Resources Information Center

Gu, Limin; Jiao, Jianli; Wang, Xiaodong; Jia, Yimin; Qin, Dan; Lindberg, J. Ola

2012-01-01

In this paper, the progress of a three-year cooperative project investigating the current state of TPD (teacher professional development) in Sweden and China in the area of TPD and ICT (information and communication technologies) is summarized. A brief introduction to the field of TPD is given, and thereafter, ICT is related to what in the project…

Community Colleges in the Commonwealth; A Report of a Survey.

ERIC Educational Resources Information Center

Blee, Myron R.; And Others

Since the Kentucky community college network has been in operation for several years, it was felt that a study of the current status and dimensions of that network would be useful in developing guidelines for future development. After visits to each of the schools and study of related data, it was noted that the community colleges are closely…

Embedding Education for Sustainable Development in Higher Education: A Case Study Examining Common Challenges and Opportunities for Undergraduate Programmes

ERIC Educational Resources Information Center

Jones, Paula; Trier, Colin J.; Richards, Jonathan P.

2008-01-01

This paper explores the perceptions of academics and students towards embedding Education for Sustainable Development (ESD) into undergraduate degree programmes in the School for Earth, Ocean and Environmental Science (SEOES) at the University of Plymouth. The main purpose of the research was to identify current ESD related teaching and learning…

Measures of Cortical Grey Matter Structure and Development in Children with Autism Spectrum Disorder

ERIC Educational Resources Information Center

Mak-Fan, Kathleen M.; Taylor, Margot J.; Roberts, Wendy; Lerch, Jason P.

2012-01-01

The current study examined group differences in cortical volume, surface area, and thickness with age, in a group of typically developing children and a group of children with ASD aged 6-15 years. Results showed evidence of age by group interactions, suggesting atypicalities in the relation between these measures and age in the ASD group.…

An Historical Analysis of the Development of Selected Areas of University Extension Programs in the United States, 1900-1965, as Related in Professional Literature.

ERIC Educational Resources Information Center

Jessup, Michael Hyle

This study is concerned with the historical development of certain areas of university extension--credit and noncredit courses, correspondence study, and conferences, institutes, and short courses--which appear widespread and important in current extension programs. Credit and noncredit courses and correspondence study were among the earliest…

Sustaining Young People's Enrolment Intentions in Relation to Physics: Development and Validation of a Tool

ERIC Educational Resources Information Center

Abraham, Jessy; Barker, Katrina

2014-01-01

Currently there is a need for measures to examine the issue of sustaining students' enrolment intentions over an extended period of study in physics, a subject which is generally perceived as hard and demanding by students. This paper addresses this gap in research by describing the development and the assessment of psychometric properties of the…

Sustainable Development Policies as Indicators and Pre-Conditions for Sustainability Efforts at Universities: Fact or Fiction?

ERIC Educational Resources Information Center

Leal Filho, Walter; Brandli, Luciana Londero; Becker, Deisi; Skanavis, Constantina; Kounani, Aristea; Sardi, Chrysoula; Papaioannidou, Dimitra; Paço, Arminda; Azeiteiro, Ulisses; de Sousa, Luiza Olim; Raath, Schalk; Pretorius, Rudi Wessel; Shiel, Christine; Vargas, Valeria; Trencher, Gregory; Marans, Robert W.

2018-01-01

Purpose: There is a widely held belief that sustainable development (SD) policies are essential for universities to successfully engage in matters related to sustainability, and are an indicator of the extent to which they are active in this field. This paper aims to examine the evidence which currently exists to support this assumption. It…

Validation of an Interview-Based Rating Scale Developed in Japan for Pervasive Developmental Disorders

ERIC Educational Resources Information Center

Ito, Hiroyuki; Tani, Iori; Yukihiro, Ryoji; Adachi, Jun; Hara, Koichi; Ogasawara, Megumi; Inoue, Masahiko; Kamio, Yoko; Nakamura, Kazuhiko; Uchiyama, Tokio; Ichikawa, Hironobu; Sugiyama, Toshiro; Hagiwara, Taku; Tsujii, Masatsugu

2012-01-01

The pervasive developmental disorders (PDDs) Autism Society Japan Rating Scale (PARS), an interview-based instrument for evaluating PDDs, has been developed in Japan with the aim of providing a method that (1) can be used to evaluate PDD symptoms and related support needs and (2) is simpler and easier than the currently used "gold…

A Review of the Current Literature Regarding Global Self-Esteem and Specific Self-Esteem in Adolescent Development.

ERIC Educational Resources Information Center

Kidder, Sherri L.

The general development of the concept of self-esteem is reviewed, and concerns about the research strategies and issues are discussed. This paper focuses on adolescent self-esteem. Research is presented on global self-esteem, domain specific self-esteem as it relates to global self-esteem, and the identification of self-esteem trajectories.…

The Politics of Access to Higher Education in Argentina and Brazil: A Comparative Analysis

ERIC Educational Resources Information Center

Fernandes Nogueira, Jaana Flavia

2013-01-01

Historically, higher education has played an important role in the development of societies. Indeed, this has been the case in both Argentina and Brazil. The overall goal of this dissertation is to examine the historical development and the current situation of higher education in Argentina and Brazil. In relation to history, it discusses the…

Not Just Numeracy and Literacy: Theory of Mind Development and School Readiness among Low-Income Children

ERIC Educational Resources Information Center

Cavadel, Elizabeth Woodburn; Frye, Douglas A.

2017-01-01

The current study investigated the role of theory of mind development in school readiness among 120 low-income preschool and kindergarten children. A short-term longitudinal design was used to examine relations among theory of mind, the understanding of teaching, and learning behaviors and their collective role in children's literacy and numeracy…

Considering future pharmacotherapy for PTSD.

PubMed

Friedman, Matthew J; Bernardy, Nancy C

2017-05-10

Posttraumatic stress disorder (PTSD) is a prevalent, disabling, and often chronic condition that may develop following exposure to a traumatic event. Despite the immense social and economic ramifications of PTSD, there has been relatively little recent development of new pharmacotherapies. The majority of pharmacological randomized clinical trials (RCTs) that has been conducted are now dated. Existing treatments for PTSD primarily have come out of research that tested medications developed for other disorders such as antidepressants, anti-hypertensives, antipsychotics, anticonvulsants, and anxiolytics. With an improved understanding of the complex pathophysiology of PTSD, we consider why it has taken so long to identify important targets to advance the field by addressing the underlying pathophysiology in pharmacological interventions. Exciting developments include research into PTSD-related abnormalities associated with dysregulation of adrenergic, hypothalamic-pituitary-adrenocortical, monoaminergic, peptide, glutamatergic, GABAergic, cannabinoid, opioid, and other neurotransmitter and neuroendocrine systems. Yet, this is a broad list and there are many unanswered questions. Current research on biomarkers associated with different clinical phenotypes of PTSD should lead to novel and more specific pharmacotherapeutic strategies. In this brief review, we consider key questions regarding current knowledge on pharmacological treatments for PTSD and highlight evolving practices in future research. Copyright © 2016. Published by Elsevier B.V.

[Introduction of vaccination against human papillomavirus in developing countries: update and perspectives].

PubMed

Hessel, L

2009-08-01

Cervical cancer and other diseases related to human papillomavirus (HPV) represent a global public health problem. Safe and effective vaccines are now available and already used in many industrialized countries. Immunization offers the best hope for protecting the population against a disease that is the second most deadly cancer in the developing world and the first most deadly in Africa. The World Health Organization currently recommends introduction of HVP vaccination in developing countries. Widespread vaccination could be beneficial in numerous domains other than primary prevention of cervical cancer. Efforts to overcome the numerous obstacles and speed up implementation of HVP vaccination programs are now underway in many areas ranging from related scientific issues such as epidemiology and clinical research to administrative concerns such as healthcare economics, vaccination guidelines, public acceptation, program funding, and universal access. Vaccine manufacturers have committed themselves to working in partnership with national and international organizations to ensure access to HPV vaccine for all countries regardless of economic level, Although numerous issues must be resolved to optimize the use of HPV vaccines and ensure synergistic integration of vaccination, screening and treatment, current initiatives and efforts should allow introduction of HPV vaccination in developing countries in a not too distant future.

Basic needs, rural financial markets, and appropriate technology: Toward a solution of analytical and policy issues

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farooq, M.O.

1988-01-01

The failure of the standard Growth Approach to economic development to solve the problems of underdevelopment in LDCs has caused an alternative approach, Basic Needs Approach (BNA), to attain prominence in development thought. BNA emphasizes poverty-minimizing growth. Its strategy of direct attack on poverty has better potential for LDCs' development and fulfillment of their populations' basic needs than the trickle-down mechanism of the Growth Approach. BNA requires, among other things, (a) suitable rural financial markets (RFMs) as parts of the overall financial system, and (b) indigenous technological capabilities. The financial system, if it functions as a central element in anmore » institutionalized technology policy, can link technology-related institutions that generate, evaluate, and promote appropriate technologies (ATs) with RFMs that can support adoption and diffusion of ATs in the agro-rural sector. The above argument uses Bangladesh as a case for illustration. In the light of an institutional framework presented, examined, and extended in this dissertation, it is found that Bangladesh currently does not have an institutionalized technology policy. The current organizational framework and policies related to technological development are not conducive to BNA.« less

An exploratory baseline study of boy chorister vocal behaviour and development in an intensive professional context.

PubMed

Williams, Jenevora; Welch, Graham; Howard, David M

2005-01-01

Currently, there is no existing published empirical longitudinal data on the singing behaviours and development of choristers who perform in UK cathedrals and major chapels. Longitudinal group data is needed to provide a baseline against which individual chorister development can be mapped. The choristers perform to a professional standard on a daily basis, usually with linked rehearsals, whilst also following a full school curriculum. The impact of this intensive schedule in relation to current vocal behaviour, health and future development requires investigation. Furthermore, it is also necessary to understand the relationship between the requirements of chorister singing behaviour and adolescent voice change. The paper will report the initial findings of a new longitudinal chorister study, based in one of London's cathedrals. Singing and vocal behaviours are being profiled on a six-monthly basis using data from a specially designed acoustic and behavioural instrument. The information obtained will enable us to understand better the effects of such training and performance on underlying vocal behaviour and vocal health. The findings will also have implications for singing teachers and choral directors in relation to particular methods of vocal education and rehearsal.

Significance of the Human Being as an Element in an Information System: WWII Forward Air Controllers and Close Air Support

DTIC Science & Technology

2002-03-01

the doctrine and the people involved as they related to the forward air control-close air support information system. Other areas that will be...discussed as they relate to the development of close air support include: incremental vs. radical change, organizational culture and change, and the...dynamic nature of current and future operations as they relate to information systems. The primary research objective is to explore

An examination of retention factors among registered nurses in Northeastern Ontario, Canada: Nurses intent to stay in their current position.

PubMed

Nowrouzi, Behdin; Rukholm, Ellen; Lariviere, Michel; Carter, Lorraine; Koren, Irene; Mian, Oxana; Giddens, Emilia

2016-03-10

The purpose of the study was to examine factors related to the retention of registered nurses in northeastern Ontario, Canada. A cross-sectional survey of registered nurses working in northeastern Ontario, Canada was conducted. Logistic regression analyses were used to consider intent to stay in current employment in relation to the following: 1) demographic factors, and 2) occupation and career satisfaction factors. A total of 459 (29.8% response rate) questionnaires were completed. The adjusted odds logistic regression analysis of RNs who intended to remain in their current position for the next five years, demonstrated that respondents in the 46 to 56 age group (OR: 2.65; 95% CI: 1.50 to 4.69), the importance of staff development in the organization (OR: 3.04; 95% CI: 1.13 to 8.13) northeastern Ontario lifestyle (OR: 2.61; 95% CI: 1.55 to 4.40), working in nursing for 14 to 22.5 years (OR: 2.55; 95% CI: 1.10 to 5.93), and working between 0 to 1 hour of overtime per week (OR: 1.20; 95% CI: 1.20 to 4.64) were significant factors in staying in their current position for the next five years. This study shows that a further understanding of the work environment could assist with developing retention for rural nurses. Furthermore, employers may use such information to ameliorate the working conditions of nurses, while researchers may use such evidence to develop interventions that are applicable to improving the working conditions of nurses.

Mental and behavioural disorders in the ICD-11: concepts, methodologies, and current status.

PubMed

Gaebel, Wolfgang; Zielasek, Jürgen; Reed, Geoffrey M

2017-04-30

This review provides an overview of the concepts, methods and current status of the development of the Eleventh Revision of the Mental and Behavioural Disorders chapter of the International Classification of Diseases and Related Health Problems (ICD-11) by the World Health Organization (WHO). Given the global use of the current version (ICD-10) for a wide range of applications in clinical practice and health statistics, a major aim of the development process for ICD-11 has been to increase the utility of the classification system. Expert working groups with responsibility for specific disorder groupings first suggested a set of revised diagnostic guidelines. Then surveys were performed to obtain suggestions for revisions from practicing health professionals. A completely revised structure for the classification of mental and behavioural disorders was developed and major revisions were suggested, for example, for schizophrenia and other primary psychotic disorders, substance use disorders, affective disorders and personality disorders. A new category of "gaming disorder" has been proposed and conditions related to sexual health and gender identity will be classified separately from mental disorders. An ICD-11 beta draft is freely available on the internet and public comments are invited. Field studies of the revised diagnostic guidelines are in process to obtain additional information about necessary improvements. A tabulated crosswalk from previous ICD-10 to then ICD-11 criteria will be necessary to ascertain the continuity of diagnoses for epidemiological and other statistical purposes. The final version of ICD-11 is currently scheduled for release by the World Health Assembly in 2018.

Development of a national audit tool for juvenile idiopathic arthritis: a BSPAR project funded by the Health Care Quality Improvement Partnership

PubMed Central

McErlane, Flora; Foster, Helen E; Armitt, Gillian; Bailey, Kathryn; Cobb, Joanna; Davidson, Joyce E; Douglas, Sharon; Fell, Andrew; Friswell, Mark; Pilkington, Clarissa; Strike, Helen; Smith, Nicola; Thomson, Wendy; Cleary, Gavin

2018-01-01

Abstract Objective Timely access to holistic multidisciplinary care is the core principle underpinning management of juvenile idiopathic arthritis (JIA). Data collected in national clinical audit programmes fundamentally aim to improve health outcomes of disease, ensuring clinical care is equitable, safe and patient-centred. The aim of this study was to develop a tool for national audit of JIA in the UK. Methods A staged and consultative methodology was used across a broad group of relevant stakeholders to develop a national audit tool, with reference to pre-existing standards of care for JIA. The tool comprises key service delivery quality measures assessed against two aspects of impact, namely disease-related outcome measures and patient/carer reported outcome and experience measures. Results Eleven service-related quality measures were identified, including those that map to current standards for commissioning of JIA clinical services in the UK. The three-variable Juvenile Arthritis Disease Activity Score and presence/absence of sacro-iliitis in patients with enthesitis-related arthritis were identified as the primary disease-related outcome measures, with presence/absence of uveitis a secondary outcome. Novel patient/carer reported outcomes and patient/carer reported experience measures were developed and face validity confirmed by relevant patient/carer groups. Conclusion A tool for national audit of JIA has been developed with the aim of benchmarking current clinical practice and setting future standards and targets for improvement. Staged implementation of this national audit tool should facilitate investigation of variability in levels of care and drive quality improvement. This will require engagement from patients and carers, clinical teams and commissioners of JIA services. PMID:29069424

Development of a national audit tool for juvenile idiopathic arthritis: a BSPAR project funded by the Health Care Quality Improvement Partnership.

PubMed

McErlane, Flora; Foster, Helen E; Armitt, Gillian; Bailey, Kathryn; Cobb, Joanna; Davidson, Joyce E; Douglas, Sharon; Fell, Andrew; Friswell, Mark; Pilkington, Clarissa; Strike, Helen; Smith, Nicola; Thomson, Wendy; Cleary, Gavin

2018-01-01

Timely access to holistic multidisciplinary care is the core principle underpinning management of juvenile idiopathic arthritis (JIA). Data collected in national clinical audit programmes fundamentally aim to improve health outcomes of disease, ensuring clinical care is equitable, safe and patient-centred. The aim of this study was to develop a tool for national audit of JIA in the UK. A staged and consultative methodology was used across a broad group of relevant stakeholders to develop a national audit tool, with reference to pre-existing standards of care for JIA. The tool comprises key service delivery quality measures assessed against two aspects of impact, namely disease-related outcome measures and patient/carer reported outcome and experience measures. Eleven service-related quality measures were identified, including those that map to current standards for commissioning of JIA clinical services in the UK. The three-variable Juvenile Arthritis Disease Activity Score and presence/absence of sacro-iliitis in patients with enthesitis-related arthritis were identified as the primary disease-related outcome measures, with presence/absence of uveitis a secondary outcome. Novel patient/carer reported outcomes and patient/carer reported experience measures were developed and face validity confirmed by relevant patient/carer groups. A tool for national audit of JIA has been developed with the aim of benchmarking current clinical practice and setting future standards and targets for improvement. Staged implementation of this national audit tool should facilitate investigation of variability in levels of care and drive quality improvement. This will require engagement from patients and carers, clinical teams and commissioners of JIA services. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology.

Data for development in health: a case study and monitoring framework from Kazakhstan

PubMed Central

Obermann, Konrad; Chanturidze, Tata; Richardson, Erica; Tanirbergenov, Serik; Shoranov, Marat; Nurgozhaev, Ali

2016-01-01

Healthcare reforms are often not coupled with a relevant and appropriate monitoring framework, leaving policymakers and the public without evidence about the implications of such reforms. Kazakhstan has embarked on a large-scale reform of its healthcare system in order to achieve Universal Health Coverage. The health-related 2020 Strategic Development Goals reflect this political ambition. In a case-study approach and on the basis of published and unpublished evidence as well as personal involvement and experience (A) the indicators in the 2020 Strategic Development Goals were assessed and (B) a ‘data-mapping’ exercise was conducted, where the WHO health system framework was used to describe the data available at present in Kazakhstan and comment on the different indicators regarding their usefulness for monitoring the current health-related 2020 Strategic Development Goals in Kazakhstan. It was concluded that the country’s current monitoring framework needs further development to track the progress and outcomes of policy implementation. The application of a modified WHO/World Bank/Global Fund health system monitoring framework was suggested to examine the implications of recent health sector reforms. Lessons drawn from the Kazakhstan experience on tailoring the suggested framework, collecting the data, and using the generated intelligence in policy development and decision-making can serve as a useful example for other middle-income countries, potentially enabling them to fast-track developments in the health sector. PMID:28588905

Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development.

PubMed

Lucke-Wold, Brandon Peter; Turner, Ryan Coddington; Logsdon, Aric Flint; Bailes, Julian Edwin; Huber, Jason Delwyn; Rosen, Charles Lee

2014-07-01

Significant attention has recently been drawn to the potential link between head trauma and the development of neurodegenerative disease, namely chronic traumatic encephalopathy (CTE). The acute neurotrauma associated with sports-related concussions in athletes and blast-induced traumatic brain injury in soldiers elevates the risk for future development of chronic neurodegenerative diseases such as CTE. CTE is a progressive disease distinguished by characteristic tau neurofibrillary tangles (NFTs) and, occasionally, transactive response DNA binding protein 43 (TDP43) oligomers, both of which have a predilection for perivascular and subcortical areas near reactive astrocytes and microglia. The disease is currently only diagnosed postmortem by neuropathological identification of NFTs. A recent workshop sponsored by National Institute of Neurological Disorders and Stroke emphasized the need for premortem diagnosis, to better understand disease pathophysiology and to develop targeted treatments. In order to accomplish this objective, it is necessary to discover the mechanistic link between acute neurotrauma and the development of chronic neurodegenerative and neuropsychiatric disorders such as CTE. In this review, we briefly summarize what is currently known about CTE development and pathophysiology, and subsequently discuss injury-induced pathways that warrant further investigation. Understanding the mechanistic link between acute brain injury and chronic neurodegeneration will facilitate the development of appropriate diagnostic and therapeutic options for CTE and other related disorders.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beilis, I. I.

Experiments in the last decade showed that for cathode spots in a magnetic field that obliquely intercepts the cathode surface, the current per spot increased with the transverse component of the magnetic field and decreased with the normal component. The present work analyzes the nature of cathode spot splitting in an oblique magnetic field. A physical model for cathode spot current splitting was developed, which considered the relation between the plasma kinetic pressure, self-magnetic pressure, and applied magnetic pressure in a current carrying cathode plasma jet. The current per spot was calculated, and it was found to increase with themore » tangential component of the magnetic field and to decrease with the normal component, which agrees well with the experimental dependence.« less

Retrospectively Assessed Early Motor and Current Pragmatic Language Skills in Autistic and Neurotypical Children.

PubMed

Stevenson, Jennifer L; Lindley, Caitlin E; Murlo, Nicole

2017-08-01

Autistic individuals often struggle developmentally, even in areas that are not explicit diagnostic criteria, such as motor skills. This study explored the relation between early motor skills, assessed retrospectively, and current pragmatic language skills. Caregivers of neurotypical and autistic children, matched on gender and age, completed assessments of their child's early motor development and current language abilities. Early motor skills were correlated with later pragmatic language skills, and autistic children exhibited fewer motor skills than neurotypical children. In fact, motor skills were a better predictor of an autism spectrum diagnosis than were scores on a measure of current pragmatic language. These results highlight the important role of motor skills in autism spectrum disorders.

Methodology to assess and map the potential development of forest ecosystems exposed to climate change and atmospheric nitrogen deposition: A pilot study in Germany.

PubMed

Schröder, Winfried; Nickel, Stefan; Jenssen, Martin; Riediger, Jan

2015-07-15

A methodology for mapping ecosystems and their potential development under climate change and atmospheric nitrogen deposition was developed using examples from Germany. The methodology integrated data on vegetation, soil, climate change and atmospheric nitrogen deposition. These data were used to classify ecosystem types regarding six ecological functions and interrelated structures. Respective data covering 1961-1990 were used for reference. The assessment of functional and structural integrity relies on comparing a current or future state with an ecosystem type-specific reference. While current functions and structures of ecosystems were quantified by measurements, potential future developments were projected by geochemical soil modelling and data from a regional climate change model. The ecosystem types referenced the potential natural vegetation and were mapped using data on current tree species coverage and land use. In this manner, current ecosystem types were derived, which were related to data on elevation, soil texture, and climate for the years 1961-1990. These relations were quantified by Classification and Regression Trees, which were used to map the spatial patterns of ecosystem type clusters for 1961-1990. The climate data for these years were subsequently replaced by the results of a regional climate model for 1991-2010, 2011-2040, and 2041-2070. For each of these periods, one map of ecosystem type clusters was produced and evaluated with regard to the development of areal coverage of ecosystem type clusters over time. This evaluation of the structural aspects of ecological integrity at the national level was added by projecting potential future values of indicators for ecological functions at the site level by using the Very Simple Dynamic soil modelling technique based on climate data and two scenarios of nitrogen deposition as input. The results were compared to the reference and enabled an evaluation of site-specific ecosystem changes over time which proved to be both, positive and negative. Copyright © 2015 Elsevier B.V. All rights reserved.

Performance index for virtual reality phacoemulsification surgery

NASA Astrophysics Data System (ADS)

Söderberg, Per; Laurell, Carl-Gustaf; Simawi, Wamidh; Skarman, Eva; Nordqvist, Per; Nordh, Leif

2007-02-01

We have developed a virtual reality (VR) simulator for phacoemulsification (phaco) surgery. The current work aimed at developing a performance index that characterizes the performance of an individual trainee. We recorded measurements of 28 response variables during three iterated surgical sessions in 9 subjects naive to cataract surgery and 6 experienced cataract surgeons, separately for the sculpting phase and the evacuation phase of phacoemulsification surgery. We further defined a specific performance index for a specific measurement variable and a total performance index for a specific trainee. The distribution function for the total performance index was relatively evenly distributed both for the sculpting and the evacuation phase indicating that parametric statistics can be used for comparison of total average performance indices for different groups in the future. The current total performance index for an individual considers all measurement variables included with the same weight. It is possible that a future development of the system will indicate that a better characterization of a trainee can be obtained if the various measurements variables are given specific weights. The currently developed total performance index for a trainee is statistically an independent observation of that particular trainee.

Technologies and Concepts for Reducing the Fuel Burn of Subsonic Transport Aircraft

NASA Technical Reports Server (NTRS)

Nickol, Craig L.

2012-01-01

There are many technologies under development that have the potential to enable large fuel burn reductions in the 2025 timeframe for subsonic transport aircraft relative to the current fleet. This paper identifies a potential technology suite and analyzes the fuel burn reduction potential of these technologies when integrated into advanced subsonic transport concepts. Advanced tube-and-wing concepts are developed in the single aisle and large twin aisle class, and a hybrid-wing-body concept is developed for the large twin aisle class. The resulting fuel burn reductions for the advanced tube-and-wing concepts range from a 42% reduction relative to the 777-200 to a 44% reduction relative to the 737-800. In addition, the hybrid-wingbody design resulted in a 47% fuel burn reduction relative to the 777-200. Of course, to achieve these fuel burn reduction levels, a significant amount of technology and concept maturation is required between now and 2025. A methodology for capturing and tracking concept maturity is also developed and presented in this paper.

U.S. commercial space activities - Returning the U.S. to preeminence in space

NASA Technical Reports Server (NTRS)

Stone, Barbara A.

1987-01-01

The current status of NASA's activities related to the commercial development of space is reviewed with particular reference to the emerging new commercial space activities and the post-Challenger policy developments affecting space commerce. The discussion covers the development of U.S. private sector launching capabilities, cooperative agreements with the private sector, the NASA technology utilization program, the technology applications activities of the Office of Commercial Programs, and the activities of the Centers for the Commercial Development of Space program.

Robotic assistants in personal care: A scoping review.

PubMed

Bilyea, A; Seth, N; Nesathurai, S; Abdullah, H A

2017-11-01

The aim of this study is to present an overview of the technological advances in the field of robotics developed for assistance with activities of daily living (ADL), and to present areas where further research is required. Four databases were searched for articles presenting either a novel design of one of these personal care robotic system or trial results relating to these systems. Articles presenting nine different robotic personal care systems were examined, six of which had been developed after 2005. These six also all have publications relating to their trials. In the majority of trials, patient independence was improved with operation of the robotic device for a specific subset of ADL. A map of the current state of the field of personal care robotics is presented in this study. Areas requiring further research include improving feedback and awareness, as well as refining control methods and pre-programmed behaviors. Developing an affordable, easy to use system would help fill the current gap in the commercial market. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Developing a novel Poverty in Healthcare curriculum for medical students at the University of Michigan Medical School.

PubMed

Doran, Kelly M; Kirley, Katherine; Barnosky, Andrew R; Williams, Joy C; Cheng, Jason E

2008-01-01

Nearly 90 million Americans live below 200% of the federal poverty threshold. The links between lower socioeconomic status and poor health are clear, and all physicians face the resulting challenges in patient care. Current medical school curricula do not adequately prepare students to address this issue despite recommendations from the Association of American Medical Colleges and the Institute of Medicine. In response, students and faculty at the University of Michigan Medical Center established the Poverty in Healthcare curriculum, which encompasses required learning experiences spanning all four years of undergraduate medical education. This article describes the design and implementation of this curriculum. The authors provide thorough descriptions of the individual learning experiences, including community site visits, longitudinal cases, mini-electives, and family centered experiences. The authors also discuss the history, costs, challenges, and evaluation process related to the Poverty in Healthcare curriculum, including issues specifically related to medical students' involvement in developing and implementing the curriculum. This information may be used as a guide for other medical schools in the development of curricula to address this current gap in medical student education.

The Telemetric and Holter ECG Warehouse Initiative (THEW): a Data Repository for the Design, Implementation and Validation of ECG-related Technologies

PubMed Central

Couderc, Jean-Philippe

2011-01-01

We present an initiative supported by the National Heart Lung, and Blood Institute and the Food and Drug Administration for the development of a repository containing continuous electrocardiographic information to be shared with the worldwide scientific community. We believe that sharing data reinforces open scientific inquiry. It encourages diversity of analysis and opinion while promoting new research and facilitating the education of new researchers. In this paper, we present the resources available in this initiative for the scientific community. We describe the set of ECG signals currently hosted and we briefly discuss the associated clinical information (medical history. Disease and study-specific endpoints) and software tools we propose. Currently, the repository contains more than 250GB of data from eight clinical studies including healthy individuals and cardiac patients. This data is available for the development, implementation and validation of technologies related to body-surface ECGs. To conclude, the Telemetric and Holter ECG Warehouse (THEW) is an initiative developed to benefit the scientific community and to advance the field of quantitative electrocardiography and cardiac safety. PMID:21097349

Treatment of juvenile idiopathic arthritis-associated uveitis: challenges and update.

PubMed

Rabinovich, C Egla

2011-09-01

To update the current understanding of the risk factors for poor outcomes in juvenile idiopathic arthritis-related uveitis. In addition, current therapies, both traditional and biological, are reviewed. Male sex, independent of age or antinuclear antibody status, is associated with increased ocular morbidity. Having anterior chamber inflammation on first exam increases the risk of developing vision-threatening eye complications. Presence of one complication increases the risk of developing another. Risk of cataract development associated with topical glucocorticoid use is better defined. Longer duration of remission on therapy has been found to decrease the risk of disease flare after discontinuation of methotrexate. Recent studies of both nonbiological and biological therapies for arthritis-related uveitis are discussed. With a better understanding of risk factors associated with the ocular morbidity of uveitis associated with juvenile idiopathic arthritis, aggressive therapies can be targeted for improved visual outcomes. Alternative treatments to avoid long-term corticosteroid use include the use of antimetabolites and biological therapies. More prospective comparator studies and/or use of multicenter databases are needed to better understand best treatments.

Mercury Content of Sediments in East Fork Poplar Creek: Current Assessment and Past Trends

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brooks, Scott C.; Eller, Virginia A.; Dickson, Johnbull O.

2017-01-01

This study provided new information on sediment mercury (Hg) and monomethylmercury (MMHg) content and chemistry. The current inventory of Hg in East Fork Poplar Creek (EFPC) bed sediments was estimated to be 334 kg, which represents a ~67% decrease relative to the initial investigations in 1984. MMHg sediment inventory was estimated to be 44.1 g, lower but roughly similar to past estimates. The results support the relevance and potential impacts of other active and planned investigations within the Mercury Remediation Technology Development for Lower East Fork Poplar Creek project (e.g., assessment and control of bank soil inputs, sorbents for Hgmore » and MMHg removal, re-introduction of freshwater clams to EFPC), and identify gaps in current understanding that represent opportunities to understand controlling variables that may inform future technology development studies.« less

High voltage and current, gate assisted, turn-off thyristor development

NASA Technical Reports Server (NTRS)

Nowalk, T. P.; Brewster, J. B.; Kao, Y. C.

1972-01-01

An improved high speed power switch with unique turn-off capability was developed. This gate assisted turn-off thyristor (GATT) was rated 1000 volts and 100 amperes with turn-off times of 2 microseconds. Fifty units were delivered for evaluation. In addition, test circuits designed to relate to the series inverter application were built and demonstrated. In the course of this work it was determined that the basic device design is adequate to meet the static characteristics and dynamic turn-off specification. It was further determined that the turn-on specification is critically dependent on the gate drive circuit due to the distributive nature of the cathode-gate geometry. Future work should emphasize design modifications which reduce the gate current required for fast turn-on, thereby opening the way to higher power (current) devices.

Working session 2: Tubing inspection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guerra, J.; Tapping, R.L.

1997-02-01

This session was attended by delegates from 10 countries, and four papers were presented. A wide range of issues was tabled for discussion. Realizing that there was limited time available for more detailed discussion, three topics were chosen for the more detailed discussion: circumferential cracking, performance demonstration (to focus on POD and sizing), and limits of methods. Two other subsessions were organized: one dealt with some challenges related to the robustness of current inspection methods, especially with respect to leaving cracked tubes in service, and the other with developing a chart of current NDE technology with recommendations for future development.more » These three areas are summarized in turn, along with conclusions and/or recommendations. During the discussions there were four presentations. There were two (Canada, Japan) on eddy current probe developments, both of which addressed multiarray probes that would detect a range of flaws, one (Spain) on circumferential crack detection, and one (JRC, Petten) on the recent PISC III results.« less

Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA

PubMed Central

Doritchamou, Justin; Sabbagh, Audrey; Jespersen, Jakob S.; Renard, Emmanuelle; Salanti, Ali; Nielsen, Morten A.; Deloron, Philippe; Tuikue Ndam, Nicaise

2015-01-01

The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a challenge for vaccine development. Based on detailed analysis of polymorphisms in the sequence of its ligand-binding N-terminal region, currently the main focus for vaccine development, we assessed var2csa from parasite isolates infecting pregnant women. The results reveal for the first time the presence of a major dimorphic region in the functionally critical N-terminal ID1 domain. Parasite isolates expressing VAR2CSA with particular motifs present within this domain are associated with gravidity- and parasite density-related effects. These observations are of particular interest in guiding efforts with respect to optimization of the VAR2CSA-based vaccines currently under development. PMID:26393516

Equilibrium and initial linear stability analysis of liquid metal falling film flows in a varying spanwise magnetic field

NASA Astrophysics Data System (ADS)

Gao, D.; Morley, N. B.

2002-12-01

A 2D model for MHD free surface flow in a spanwise field is developed. The model, designed to simulate film flows of liquid metals in future thermo­nuclear fusion reactors, considers an applied spanwise magnetic field with spatial and temporal variation and an applied streamwise external current. A special case - a thin falling film flow in spanwise magnetic field with constant gradient and constant applied external streamwise current, is here investigated in depth to gain insight into the behavior of the MHD film flow. The fully developed flow solution is derived and initial linear stability analysis is performed for this special case. It is seen that the velocity profile is significantly changed due to the presence of the MHD effect, resulting in the free surface analog of the classic M-shape velocity profile seen in developing pipe flows in a field gradient. The field gradient is also seen to destabilize the film flow under most conditions. The effect of external current depends on the relative direction of the field gradient to the current direction. By controlling the magnitude of an external current, it is possible to obtain a linearly stable falling film under these magnetic field conditions. Tables 1, Figs 12, Refs 20.

Remyelination Therapy in Multiple Sclerosis.

PubMed

Harlow, Danielle E; Honce, Justin M; Miravalle, Augusto A

2015-01-01

Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration. Current treatments approved for the treatment of relapsing forms of MS target the aberrant immune response and successfully reduce the severity of attacks and frequency of relapses. Therapies are still needed that can repair damage particularly for the treatment of progressive forms of MS for which current therapies are relatively ineffective. Remyelination can restore neuronal function and prevent further neuronal loss and clinical disability. Recent advancements in our understanding of the molecular and cellular mechanisms regulating myelination, as well as the development of high-throughput screens to identify agents that enhance myelination, have lead to the identification of many potential remyelination therapies currently in preclinical and early clinical development. One problem that has plagued the development of treatments to promote remyelination is the difficulty in assessing remyelination in patients with current imaging techniques. Powerful new imaging technologies are making it easier to discern remyelination in patients, which is critical for the assessment of these new therapeutic strategies during clinical trials. This review will summarize what is currently known about remyelination failure in MS, strategies to overcome this failure, new therapeutic treatments in the pipeline for promoting remyelination in MS patients, and new imaging technologies for measuring remyelination in patients.

The Potential of Human Stem Cells for the Study and Treatment of Glaucoma

PubMed Central

Chamling, Xitiz; Sluch, Valentin M.; Zack, Donald J.

2016-01-01

Purpose Currently, the only available and approved treatments for glaucoma are various pharmacologic, laser-based, and surgical procedures that lower IOP. Although these treatments can be effective, they are not always sufficient, and they cannot restore vision that has already been lost. The goal of this review is to briefly assess current developments in the application of stem cell biology to the study and treatment of glaucoma and other forms of optic neuropathy. Methods A combined literature review and summary of the glaucoma-related discussion at the 2015 “Sight Restoration Through Stem Cell Therapy” meeting that was sponsored by the Ocular Research Symposia Foundation (ORSF). Results Ongoing advancements in basic and eye-related developmental biology have enabled researchers to direct murine and human stem cells along specific developmental paths and to differentiate them into a variety of ocular cell types of interest. The most advanced of these efforts involve the differentiation of stem cells into retinal pigment epithelial cells, work that has led to the initiation of several human trials. More related to the glaucoma field, there have been recent advances in developing protocols for differentiation of stem cells into trabecular meshwork and retinal ganglion cells. Additionally, efforts are being made to generate stem cell–derived cells that can be used to secrete neuroprotective factors. Conclusions Advancing stem cell technology provides opportunities to improve our understanding of glaucoma-related biology and develop models for drug development, and offers the possibility of cell-based therapies to restore sight to patients who have already lost vision. PMID:27116666

An efficient agro-industrial complex in Almería (Spain): Towards an integrated and sustainable bioeconomy model.

PubMed

Egea, Francisco J; Torrente, Roberto G; Aguilar, Alfredo

2018-01-25

In the last ten years, bioeconomy strategies and policy-related bioeconomy initiatives have been developed all over the world. Some of them are currently in the process of translation into specific actions. In most cases, the approaches followed have been top-down policy-related initiatives, triggered by the public sector originating a dynamic which can bring together different bioeconomy stakeholders i.e. industry, academia, financial operators and farmers. This article describes a bottom-up situation with unique bioeconomy-related features that deserve specific attention. Over the last 40 years, Almería, in the south east of Spain, has developed one of the most efficient agro-industrial complexes in the world, evolving from a traditional and subsistence agriculture, to becoming the major vegetable exporter in the European Union (EU). This growth set aside issues such as sustainability, long-term perspectives on water resources or agricultural waste. However, societal concerns about a circular economy, as well as policy initiatives in the EU and in Spain on bioeconomy are changing the situation towards an integrated, efficient and sustainable bioeconomy system. Currently, the production chain demands innovations related to the use of biomass as source of bioproducts and bioenergy in order to remain competitive. Some positive aspects are the relatively small size of the agro-industrial area, making transport and communications rapid and easy, and the existence of strong and dedicated academic and financial institutions. This article outlines the current efforts and initiatives to couple the existing successful agro-industrial complex with that of a fully sustainable bioeconomy model. Copyright © 2017 Elsevier B.V. All rights reserved.

Virtual Reality: Ready or Not!

ERIC Educational Resources Information Center

Lewis, Joan E.

1994-01-01

Describes the development and current status of virtual reality (VR) and VR research. Market potentials for VR are discussed, including the entertainment industry, health care and medical training, flight and other simulators, and educational possibilities. A glossary of VR-related terms is included. (LRW)

SITE PROGRAM CURRENT AND FUTURE INNOVATIVE TECHNIQUES FOR GROUNDWATER TREATMENT

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Office of Research and Development (ORD) conducts research related to the demonstration and evaluation of innovative cleanup technologies. One of the mechanisms for the evaluation of innovative field-scale technologies for hazardous ...

Let's Not Be Shy about Marketing.

ERIC Educational Resources Information Center

Trachtenberg, Stephen Joel

1984-01-01

Attitudes about college marketing have hindered its progress. It is an informative process with strong feedback, including such elements as information gathering, travel, development of a marketing or public relations plan, organizational communication, institutional adaptation to the current market, and administrator input. (MSE)

Contemporary Play Therapy: Theory, Research, and Practice

ERIC Educational Resources Information Center

Schaefer, Charles E., Ed.; Gerard Kaduson, Heidi, Ed.

2006-01-01

This highly practical book presents current developments in play therapy, including innovative applications for particular problems and populations. Contributors first discuss the latest ideas and techniques emerging from object-relations, experiential, dynamic, and narrative perspectives. Next, research evaluating the effectiveness of play…

Computer modeling of high-voltage solar array experiment using the NASCAP/LEO (NASA Charging Analyzer Program/Low Earth Orbit) computer code

NASA Astrophysics Data System (ADS)

Reichl, Karl O., Jr.

1987-06-01

The relationship between the Interactions Measurement Payload for Shuttle (IMPS) flight experiment and the low Earth orbit plasma environment is discussed. Two interactions (parasitic current loss and electrostatic discharge on the array) may be detrimental to mission effectiveness. They result from the spacecraft's electrical potentials floating relative to plasma ground to achieve a charge flow equilibrium into the spacecraft. The floating potentials were driven by external biases applied to a solar array module of the Photovoltaic Array Space Power (PASP) experiment aboard the IMPS test pallet. The modeling was performed using the NASA Charging Analyzer Program/Low Earth Orbit (NASCAP/LEO) computer code which calculates the potentials and current collection of high-voltage objects in low Earth orbit. Models are developed by specifying the spacecraft, environment, and orbital parameters. Eight IMPS models were developed by varying the array's bias voltage and altering its orientation relative to its motion. The code modeled a typical low Earth equatorial orbit. NASCAP/LEO calculated a wide variety of possible floating potential and current collection scenarios. These varied directly with both the array bias voltage and with the vehicle's orbital orientation.

The current state of cancer family history collection tools in primary care: a systematic review.

PubMed

Qureshi, Nadeem; Carroll, June C; Wilson, Brenda; Santaguida, Pasqualina; Allanson, Judith; Brouwers, Melissa; Raina, Parminder

2009-07-01

Systematic collection of family history is a prerequisite for identifying genetic risk. This study reviewed tools applicable to the primary care assessment of family history of breast, colorectal, ovarian, and prostate cancer. MEDLINE, EMBASE, CINAHL, and Cochrane Central were searched for publications. All primary study designs were included. Characteristics of the studies, the family history collection tools, and the setting were evaluated. Of 40 eligible studies, 18 relevant family history tools were identified, with 11 developed for use in primary care. Most collected information on more than one cancer and on affected relatives used self-administered questionnaires and paper-based formats. Eleven tools had been evaluated relative to current practice, demonstrating 46-78% improvement in data recording over family history recording in patient charts and 75-100% agreement with structured genetic interviews. Few tools have been developed specifically for primary care settings. The few that have been evaluated performed well. The very limited evidence, which depends in part on extrapolation from studies in settings other than primary care, suggests that systematic tools may add significant family health information compared with current primary care practice. The effect of their use on health outcomes has not been evaluated.

RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting.

PubMed

Sherman, James H; Munyikwa, Tichafa; Chan, Stephen Y; Petrick, Jay S; Witwer, Kenneth W; Choudhuri, Supratim

2015-11-01

During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The meeting session described herein focused on the technology of RNA interference (RNAi) in agriculture. The general process by which RNAi works, currently registered RNAi-based plant traits, example RNAi-based traits in development, potential use of double stranded RNA (dsRNA) as topically applied pesticide active ingredients, research related to the safety of RNAi, biological barriers to ingested dsRNA, recent regulatory RNAi science reviews, and regulatory considerations related to the use of RNAi in agriculture were discussed. Participants generally agreed that the current regulatory framework is robust and appropriate for evaluating the safety of RNAi employed in agricultural biotechnology and were also supportive of the use of RNAi to develop improved crop traits. However, as with any emerging technology, the potential range of future products, potential future regulatory frameworks, and public acceptance of the technology will continue to evolve. As such, continuing dialogue was encouraged to promote education of consumers and science-based regulations. Copyright © 2015 Elsevier Inc. All rights reserved.

Role of PRMTs in cancer: Could minor isoforms be leaving a mark?

PubMed Central

Baldwin, R Mitchell; Morettin, Alan; Côté, Jocelyn

2014-01-01

Protein arginine methyltransferases (PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of the known alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. PMID:24921003

Role of PRMTs in cancer: Could minor isoforms be leaving a mark?

PubMed

Baldwin, R Mitchell; Morettin, Alan; Côté, Jocelyn

2014-05-26

Protein arginine methyltransferases (PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of the known alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies.

Exploration of the Chemical Space of Public Genomic ...

EPA Pesticide Factsheets

The current project aims to chemically index the content of public genomic databases to make these data accessible in relation to other publicly available, chemically-indexed toxicological information. By evaluating the chemical space of public genomic data in relation to public toxicological data, it is possible to identify classes of chemicals on which to develop methodologies for the integration of chemogenomic data into predictive toxicology.

Cognitive Abilities Explaining Age-Related Changes in Time Perception of Short and Long Durations

ERIC Educational Resources Information Center

Zelanti, Pierre S.; Droit-Volet, Sylvie

2011-01-01

The current study investigated how the development of cognitive abilities explains the age-related changes in temporal judgment over short and long duration ranges from 0.5 to 30 s. Children (5- and 9-year-olds) as well as adults were given a temporal bisection task with four different duration ranges: a duration range shorter than 1 s, two…

Using More than 10% of Our Brains: Examining Belief in Science-Related Myths from an Individual Differences Perspective

ERIC Educational Resources Information Center

Swami, Viren; Stieger, Stefan; Pietschnig, Jakob; Nader, Ingo W.; Voracek, Martin

2012-01-01

There currently exists a dearth of research on the transmission and assimilation of myths. To overcome this limitation, we developed a novel scale that measures belief in science-related myths. A total of 363 participants completed this new scale along with measures of personality (the Big Five factors), anti-scientific attitudes, and New Age…

Assessing Deictic Relational Responding in Social Anhedonia: A Functional Approach to the Development of Theory of Mind Impairments

ERIC Educational Resources Information Center

Villatte, Matthieu; Monestes, Jean-Louis; McHugh, Louise; Freixa i Baque, Esteve; Loas, Gwenole; Loas, Amiens

2008-01-01

The current study aimed to compare deictic relational responding and Theory of Mind (ToM) performances in 60 non-clinical young adults with a profile of high versus low social anhedonia in order to investigate a possible link between social anhedonia and ToM functioning. The results indicated that social anhedonic participants were less accurate…

Developing a Model of Advanced Training to Promote Career Advancement for Certified Genetic Counselors: An Investigation of Expanded Skills, Advanced Training Paths, and Professional Opportunities.

PubMed

Baty, Bonnie J; Trepanier, Angela; Bennett, Robin L; Davis, Claire; Erby, Lori; Hippman, Catriona; Lerner, Barbara; Matthews, Anne; Myers, Melanie F; Robbins, Carol B; Singletary, Claire N

2016-08-01

There are currently multiple paths through which genetic counselors can acquire advanced knowledge and skills. However, outside of continuing education opportunities, there are few formal training programs designed specifically for the advanced training of genetic counselors. In the genetic counseling profession, there is currently considerable debate about the paths that should be available to attain advanced skills, as well as the skills that might be needed for practice in the future. The Association of Genetic Counseling Program Directors (AGCPD) convened a national committee, the Committee on Advanced Training for Certified Genetic Counselors (CATCGC), to investigate varied paths to post-master's training and career development. The committee began its work by developing three related grids that view career advancement from the viewpoints of the skills needed to advance (skills), ways to obtain these skills (paths), and existing genetic counselor positions that offer career change or advancement (positions). Here we describe previous work related to genetic counselor career advancement, the charge of the CATCGC, our preliminary work in developing a model through which to view genetic counselor advanced training and career advancement opportunities, and our next steps in further developing and disseminating the model.

Mentoring. A quality assurance tool for dentists part 5: the roots of the modern approach to mentoring and coaching.

PubMed

Holt, Vernon P; Ladwa, Russ

2009-10-01

Mentoring and coaching, as they are currently practised, are relatively new techniques for working with people. The roots of the current approach can be traced back to the psychotherapist Carl Rogers, who developed a new 'person-centred approach' to counselling and quickly realised that this approach was also appropriate for many types of relationship, from education to family life. Rogers' thinking was deeply influenced by dialogues with his friend, the existentialist philosopher Martin Buber. Developments in psychology building upon this new person-centred approach include transactional analysis (TA) and neurolingusitic programming (NLP). More recently, solutions-focused approaches have been used and a related approach to leadership in the business environment-strengths-based leadership-has been developed. In recent years, developments in neuroscience have greatly increased understanding not only of how the brain is 'wired up' but also of how it is specifically wired to function as a social organ. The increased understanding in these areas can be considered in the context of emotional and social intelligence. These concepts and knowledge have been drawn together into a more structured discipline with the development of the approach known as positive psychology, the focus of which is on the strengths and virtues that contribute to good performance and authentic happiness.

Recent developments with boron as a platform for novel drug design.

PubMed

Leśnikowski, Zbigniew J

2016-06-01

After decades of development, the medicinal chemistry of compounds that contain a single boron atom has matured to the present status of having equal rights with other branches of drug discovery, although it remains a relative newcomer. In contrast, the medicinal chemistry of boron clusters is less advanced, but it is expanding and may soon become a productive area of drug discovery. The author reviews the current developments of medicinal chemistry of boron and its applications in drug design. First generation boron drugs that bear a single boron atom and second generation boron drugs that utilize boron clusters as pharmacophores or modulators of bioactive molecules are discussed. The advantages and gaps in our current understanding of boron medicinal chemistry, with a special focus on boron clusters, are highlighted. Boron is not a panacea for every drug discovery problem, but there is a good chance that it will become a useful addition to the medicinal chemistry tool box. The present status of boron resembles the medicinal chemistry status of fluorine three decades ago; indeed, currently, approximately 20% of pharmaceuticals on the market contain fluorine. The fact that novel boron compounds, especially those based on abiotic polyhedral boron hydrides, are currently unfamiliar could be advantageous because organisms may be less prone to developing resistance against boron cluster-based drugs.

The use of pyro-polymeric catalysts and a new cylindrical cell design in oxygen-aluminum generators

NASA Astrophysics Data System (ADS)

Kiseleva, E. A.; Zhuk, A. Z.; Kleymenov, B. V.; Oudaltsov, V. G.

2018-01-01

The increase in energy consumption, the economic crisis, the development of certain areas of engineering and energy, as well as the related deterioration of the environmental situation, require the development of new electrochemical current sources with high specific characteristics. In the field of creating air-hydrogen fuel cells, the problems of safety and mobile storage of hydrogen have not been completely solved, stagnation in the development of lithium-ion, lithium-air and lithium-sulfur batteries has been outlined. All this requires searching for new technological solutions, ways to increase the energy and resource characteristics of electrochemical current sources (ECS), reducing their cost [1-2]. The use of metals (aluminum, zinc, magnesium) as an energy carrier is due to their high energy intensity (in combination with the lack of transport, storage and on-board storage problems) of the relatively low cost of metals, their availability, storage safety and the absence of harmful emissions when used. As in the chemical and electrochemical use of metals, safe products (oxides, hydroxides) are formed, which are reduced to metals within the framework of traditional production technologies. Thus, a closed cycle of energy use is organized. The task of this paper is to evaluate the possibility of reducing the cost and increasing the specific power of ECS using oxygen depolarization. The goal is achieved by using non-platinum catalysts and optimizing the design of the current source.

Exact solutions and low-frequency instability of the adiabatic auroral arc model

NASA Technical Reports Server (NTRS)

Cornwall, John M.

1988-01-01

The adiabatic auroral arc model couples a kinetic theory parallel current driven by mirror forces to horizontal ionospheric currents; the resulting equations are nonlinear. Some exact stationary solutions to these equations, some of them based on the Liouville equation, are developed, with both latitudinal and longitudinal spatial variations. These Liouville equation exact solutions are related to stability boundaries of low-frequency instabilities such as Kelvin-Helmholtz, as shown by a study of a simplified model.

Magnetic tearing of plasma discharges due to nonuniform resistivity

NASA Technical Reports Server (NTRS)

Hassam, A. B.

1988-01-01

The rearrangement of current in a plasma discharge in response to resistivity nonuniformities within a magnetic surface is studied. It is shown that macroscopic magnetic islands develop about those surfaces where the nonuniformity is aligned with the magnetic field. If the nonuniformity and the field are not aligned anywhere, there is no current rearrangement; instead, relatively large plasma flows are set up. Such resistivity inhomogeneities can obtain in solar coronal loops and, in some circumstances, in tokamak discharges.

Emergence of Adaptive Computation by Single Neurons in the Developing Cortex

PubMed Central

Famulare, Michael; Gjorgjieva, Julijana; Moody, William J.

2013-01-01

Adaptation is a fundamental computational motif in neural processing. To maintain stable perception in the face of rapidly shifting input, neural systems must extract relevant information from background fluctuations under many different contexts. Many neural systems are able to adjust their input–output properties such that an input's ability to trigger a response depends on the size of that input relative to its local statistical context. This “gain-scaling” strategy has been shown to be an efficient coding strategy. We report here that this property emerges during early development as an intrinsic property of single neurons in mouse sensorimotor cortex, coinciding with the disappearance of spontaneous waves of network activity, and can be modulated by changing the balance of spike-generating currents. Simultaneously, developing neurons move toward a common intrinsic operating point and a stable ratio of spike-generating currents. This developmental trajectory occurs in the absence of sensory input or spontaneous network activity. Through a combination of electrophysiology and modeling, we demonstrate that developing cortical neurons develop the ability to perform nearly perfect gain scaling by virtue of the maturing spike-generating currents alone. We use reduced single neuron models to identify the conditions for this property to hold. PMID:23884925

Translating emotion theory and research into preventive interventions.

PubMed

Izard, Carroll E

2002-09-01

Scientific advances in the field of emotions suggest a framework for conceptualizing the emotion-related aspects of prevention programs that aim to enhance children's socioemotional competence and prevent the emergence of behavior problems and psychopathology. A conception of emotions as inherently adaptive and motivational and the related empirical evidence from several disciplines and specialities suggest 7 principles for developing preventive interventions: the utilization of positive and negative emotions, emotion modulation as a mediator of emotion utilization, emotion patterns in states and traits, different processes of emotion activation, emotion communication in early life, and the development of connections for the modular and relatively independent emotions and cognitive systems. Each principle's practical implications and application in current prevention programs are discussed.

Environmental Impact of Flame Retardants (Persistence and Biodegradability)

PubMed Central

Segev, Osnat; Kushmaro, Ariel; Brenner, Asher

2009-01-01

Flame-retardants (FR) are a group of anthropogenic environmental contaminants used at relatively high concentrations in many applications. Currently, the largest market group of FRs is the brominated flame retardants (BFRs). Many of the BFRs are considered toxic, persistent and bioaccumulative. Bioremediation of contaminated water, soil and sediments is a possible solution for the problem. However, the main problem with this approach is the lack of knowledge concerning appropriate microorganisms, biochemical pathways and operational conditions facilitating degradation of these chemicals at an acceptable rate. This paper reviews and discusses current knowledge and recent developments related to the environmental fate and impact of FRs in natural systems and in engineered treatment processes. PMID:19440395

Lightweight, Room-Temperature CO2 Gas Sensor Based on Rare-Earth Metal-Free Composites—An Impedance Study

PubMed Central

2017-01-01

We report a light, flexible, and low-power poly(ionic liquid)/alumina composite CO2 sensor. We monitor the direct-current resistance changes as a function of CO2 concentration and relative humidity and demonstrate fast and reversible sensing kinetics. Moreover, on the basis of the alternating-current impedance measurements we propose a sensing mechanism related to proton conduction and gas diffusion. The findings presented herein will promote the development of organic/inorganic composite CO2 gas sensors. In the future, such sensors will be useful for numerous practical applications ranging from indoor air quality control to the monitoring of manufacturing processes. PMID:28726384

Problems of the theory of superconductivity which involve spatial inhomogeneity

NASA Astrophysics Data System (ADS)

Svidzinskii, A. V.

This book is concerned with questions which are related to equilibrium phenomena in superconductors, giving particular attention to effects determined by a spatial variation of the order parameter. The microscopic theory of superconductivity is developed on the basis of a model which takes into account the direct interaction between electrons. The theory of current relations in superconductors is discussed, taking into consideration the magnetic properties of superconductors in weak fields and the Meissner effect. Aspects regarding the general theory of tunneling are also explored, including the Josephson effect. An investigation is conducted of the theory of current conditions in areas in which the superconductor is in contact with normally conducting metal.

Recent Progress in Cancer-Related Lymphedema Treatment and Prevention

PubMed Central

Shaitelman, Simona F.; Cromwell, Kate D.; Rasmussen, John C.; Stout, Nicole L.; Armer, Jane M.; Lasinski, Bonnie B.; Cormier, Janice N.

2016-01-01

This article provides an overview of the recent developments in the diagnosis, treatment, and prevention of cancer-related lymphedema. Lymphedema incidence by tumor site is evaluated. Measurement techniques and trends in patient education and treatment are also summarized to include current trends in therapeutic and surgical treatment options as well as longer-term management. Finally, an overview of the policies related to insurance coverage and reimbursement will give the clinician an overview of important trends in the diagnosis, treatment, and management of cancer-related lymphedema. PMID:25410402

Age-related macular degeneration: current treatments

PubMed Central

Hubschman, Jean Pierre; Reddy, Shantan; Schwartz, Steven D

2009-01-01

Purpose: Although important progress has been made in understanding age-related macular degeneration (AMD), management of the disease continues to be a challenge. AMD research has led to a widening of available treatment options and improved prognostic perspectives. This essay reviews these treatment options. Design: Interpretative essay. Methods: Literature review and interpretation. Results: Current treatments to preserve vision in patients with non-exudative AMD include antioxidant vitamins and mineral supplementations. Exudative AMD is currently most often treated monthly with anti-VEGF intravitreal injections. However, investigators are beginning to experiment with combination therapy and surgical approaches in an attempt to limit the number of treatment and reduce the financial burden on the health care system. Conclusion: By better understanding the basis and pathogenesis of AMD, newer therapies will continue to be developed that target specific pathways in patients with AMD, with the hoped for outcome of better management of the disease and improved visual acuity. PMID:19668560

Current thoughts on maternal nutrition and fetal programming of the metabolic syndrome.

PubMed

Brenseke, Bonnie; Prater, M Renee; Bahamonde, Javiera; Gutierrez, J Claudio

2013-01-01

Chronic diseases such as type 2 diabetes and cardiovascular disease are the leading cause of death and disability worldwide. Although the metabolic syndrome has been defined in various ways, the ultimate importance of recognizing this combination of disorders is that it helps identify individuals at high risk for both type 2 diabetes and cardiovascular disease. Evidence from observational and experimental studies links adverse exposures in early life, particularly relating to nutrition, to chronic disease susceptibility in adulthood. Such studies provide the foundation and framework for the relatively new field of developmental origins of health and disease (DOHaD). Although great strides have been made in identifying the putative concepts and mechanisms relating specific exposures in early life to the risk of developing chronic diseases in adulthood, a complete picture remains obscure. To date, the main focus of the field has been on perinatal undernutrition and specific nutrient deficiencies; however, the current global health crisis of overweight and obesity demands that perinatal overnutrition and specific nutrient excesses be examined. This paper assembles current thoughts on the concepts and mechanisms behind the DOHaD as they relate to maternal nutrition, and highlights specific contributions made by macro- and micronutrients.

Microsurgery Training for the Twenty-First Century

PubMed Central

Myers, Simon Richard; Froschauer, Stefan; Akelina, Yelena; Tos, Pierluigi; Kim, Jeong Tae

2013-01-01

Current educational interventions and training courses in microsurgery are often predicated on theories of skill acquisition and development that follow a 'practice makes perfect' model. Given the changing landscape of surgical training and advances in educational theories related to skill development, research is needed to assess current training tools in microsurgery education and devise alternative methods that would enhance training. Simulation is an increasingly important tool for educators because, whilst facilitating improved technical proficiency, it provides a way to reduce risks to both trainees and patients. The International Microsurgery Simulation Society has been founded in 2012 in order to consolidate the global effort in promoting excellence in microsurgical training. The society's aim to achieve standarisation of microsurgical training worldwide could be realised through the development of evidence based educational interventions and sharing best practices. PMID:23898422

Taking stock of Myanmar's progress toward the health-related Millennium Development Goals: current roadblocks, paths ahead.

PubMed

Saw, Yu Mon; Win, Khine Lae; Shiao, Laura Wen-Shuan; Thandar, Moe Moe; Amiya, Rachel M; Shibanuma, Akira; Tun, Soe; Jimba, Masamine

2013-09-11

Myanmar is a developing country with considerable humanitarian needs, rendering its pursuit of the Millennium Development Goals (MDGs) an especially high priority. Yet progress to date remains under-examined on key fronts. Particularly within the three health-related MDGs (MDGs 4, 5, and 6), the limited data reported point to patchy levels of achievement. This study was undertaken to provide an overview and assessment of Myanmar's progress toward the health-related MDGs, along with possible solutions for accelerating health-related development into 2015 and beyond. The review highlights off-track progress in the spheres of maternal and child health (MDGs 4 and 5). It also shows Myanmar's achievements toward MDG 6 targets--in the areas of HIV/AIDS, malaria, and tuberculosis. Such achievements are especially notable in that Myanmar has been receiving the lowest level of official development assistance among all of the least developed countries in Asia. However, to make similar progress in MDGs 4 and 5, Myanmar needs increased investment and commitment in health. Toward moving forward with the post-2015 development agenda, Myanmar's government also needs to take the lead in calling for attention from the World Health Organization and its global development partners to address the stagnation in health-related development progress within the country. In particular, Myanmar's government should invest greater efforts into health system strengthening to pave the road to universal health coverage.

How much work-related injury and illness is missed by the current national surveillance system?

PubMed

Rosenman, Kenneth D; Kalush, Alice; Reilly, Mary Jo; Gardiner, Joseph C; Reeves, Mathew; Luo, Zhewui

2006-04-01

We sought to estimate the undercount in the existing national surveillance system of occupational injuries and illnesses. Adhering to the strict confidentiality rules of the U.S. Bureau of Labor Statistics, we matched the companies and individuals who reported work-related injuries and illnesses to the Bureau in 1999, 2000, and 2001 in Michigan with companies and individuals reported in four other Michigan data bases, workers' compensation, OSHA Annual Survey, OSHA Integrated Management Information System, and the Occupational Disease Report. We performed capture-recapture analysis to estimate the number of cases missed by the combined systems. We calculated that the current national surveillance system did not include 61% and with capture-recapture analysis up to 68% of the work-related injuries and illnesses that occurred annually in Michigan. This was true for injuries alone, 60% and 67%, and illnesses alone 66% and 69%, respectively. The current national system for work-related injuries and illnesses markedly underestimates the magnitude of these conditions. A more comprehensive system, such as the one developed for traumatic workplace fatalities, that is not solely dependent on employer based data sources is needed to better guide decision-making and evaluation of public health programs to reduce work-related conditions.

Workplace road safety risk management: An investigation into Australian practices.

PubMed

Warmerdam, Amanda; Newnam, Sharon; Sheppard, Dianne; Griffin, Mark; Stevenson, Mark

2017-01-01

In Australia, more than 30% of the traffic volume can be attributed to work-related vehicles. Although work-related driver safety has been given increasing attention in the scientific literature, it is uncertain how well this knowledge has been translated into practice in industry. It is also unclear how current practice in industry can inform scientific knowledge. The aim of the research was to use a benchmarking tool developed by the National Road Safety Partnership Program to assess industry maturity in relation to risk management practices. A total of 83 managers from a range of small, medium and large organisations were recruited through the Victorian Work Authority. Semi-structured interviews aimed at eliciting information on current organisational practices, as well as policy and procedures around work-related driving were conducted and the data mapped onto the benchmarking tool. Overall, the results demonstrated varying levels of maturity of risk management practices across organisations, highlighting the need to build accountability within organisations, improve communication practices, improve journey management, reduce vehicle-related risk, improve driver competency through an effective workplace road safety management program and review organisational incident and infringement management. The findings of the study have important implications for industry and highlight the need to review current risk management practices. Copyright © 2016 Elsevier Ltd. All rights reserved.

Rates of species accumulation and taxonomic diversification during phototrophic biofilm development are controlled by both nutrient supply and current velocity.

PubMed

Larson, Chad A; Passy, Sophia I

2013-03-01

The accumulation of new and taxonomically diverse species is a marked feature of community development, but the role of the environment in this process is not well understood. To address this problem, we subjected periphyton in laboratory streams to low (10-cm · s(-1)), high (30-cm · s(-1)), and variable (9- to 32-cm · s(-1)) current velocity and low- versus high-nutrient inputs. We examined how current velocity and resource supply constrained (i) the rates of species accumulation, a measure of temporal beta-diversity, and (ii) the rates of diversification of higher taxonomic categories, defined here as the rate of higher taxon richness increase with the increase of species richness. Temporal biofilm dynamics were controlled by a strong nutrient-current interaction. Nutrients accelerated the rates of accumulation of new species, when flow velocity was not too stressful. Species were more taxonomically diverse under variable than under low-flow conditions, indicating that flow heterogeneity increased the niche diversity in the high-nutrient treatments. Conversely, the lower diversification rates under high- than under low-nutrient conditions at low velocity are explained with finer resource partitioning among species, belonging to a limited number of related genera. The overall low rates of diversification in high-current treatments suggest that the ability to withstand current stress was conserved within closely related species. Temporal heterogeneity of disturbance has been shown to promote species richness, but here we further demonstrate that it also affects two other components of biodiversity, i.e., temporal beta-diversity and diversification rate. Therefore, management efforts for preserving the inherent temporal heterogeneity of natural ecosystems will have detectable positive effects on biodiversity.

Rates of Species Accumulation and Taxonomic Diversification during Phototrophic Biofilm Development Are Controlled by both Nutrient Supply and Current Velocity

PubMed Central

2013-01-01

The accumulation of new and taxonomically diverse species is a marked feature of community development, but the role of the environment in this process is not well understood. To address this problem, we subjected periphyton in laboratory streams to low (10-cm · s−1), high (30-cm · s−1), and variable (9- to 32-cm · s−1) current velocity and low- versus high-nutrient inputs. We examined how current velocity and resource supply constrained (i) the rates of species accumulation, a measure of temporal beta-diversity, and (ii) the rates of diversification of higher taxonomic categories, defined here as the rate of higher taxon richness increase with the increase of species richness. Temporal biofilm dynamics were controlled by a strong nutrient-current interaction. Nutrients accelerated the rates of accumulation of new species, when flow velocity was not too stressful. Species were more taxonomically diverse under variable than under low-flow conditions, indicating that flow heterogeneity increased the niche diversity in the high-nutrient treatments. Conversely, the lower diversification rates under high- than under low-nutrient conditions at low velocity are explained with finer resource partitioning among species, belonging to a limited number of related genera. The overall low rates of diversification in high-current treatments suggest that the ability to withstand current stress was conserved within closely related species. Temporal heterogeneity of disturbance has been shown to promote species richness, but here we further demonstrate that it also affects two other components of biodiversity, i.e., temporal beta-diversity and diversification rate. Therefore, management efforts for preserving the inherent temporal heterogeneity of natural ecosystems will have detectable positive effects on biodiversity. PMID:23335757

Cognitive dissonance in food and nutrition-A review.

PubMed

Ong, Andy Swee-Jin; Frewer, Lynn; Chan, Mei-Yen

2017-07-24

The study of cognitive dissonance in food and nutrition has been relatively under-developed. This review paper looks at food and/or food-related studies that have utilized cognitive dissonance as a primary construct in a priori theorization and hypothesis-formulation, examining the ways in which the dissonance construct has been used and its corresponding effects on various food-related outcomes in those studies. Current gaps and critical issues underlying cognitive dissonance investigation in food and nutrition research are also identified and discussed.

Gene Editing of Microalgae: Scientific Progress and Regulatory Challenges in Europe

PubMed Central

Spicer, Andrew

2018-01-01

It is abundantly clear that the development of gene editing technologies, represents a potentially powerful force for good with regard to human and animal health and addressing the challenges we continue to face in a growing global population. This now includes the development of approaches to modify microalgal strains for potential improvements in productivity, robustness, harvestability, processability, nutritional composition, and application. The rapid emergence and ongoing developments in this area demand a timely review and revision of the current definitions and regulations around genetically modified organisms (GMOs), particularly within Europe. Current practices within the EU provide exemptions from the GMO directives for organisms, including crop plants and micro-organisms that are produced through chemical or UV/radiation mutagenesis. However, organisms generated through gene editing, including microalgae, where only genetic changes in native genes are made, remain currently under the GMO umbrella; they are, as such, excluded from practical and commercial opportunities in the EU. In this review, we will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GM microalgae in Europe. PMID:29509719

Gene Editing of Microalgae: Scientific Progress and Regulatory Challenges in Europe.

PubMed

Spicer, Andrew; Molnar, Attila

2018-03-06

It is abundantly clear that the development of gene editing technologies, represents a potentially powerful force for good with regard to human and animal health and addressing the challenges we continue to face in a growing global population. This now includes the development of approaches to modify microalgal strains for potential improvements in productivity, robustness, harvestability, processability, nutritional composition, and application. The rapid emergence and ongoing developments in this area demand a timely review and revision of the current definitions and regulations around genetically modified organisms (GMOs), particularly within Europe. Current practices within the EU provide exemptions from the GMO directives for organisms, including crop plants and micro-organisms that are produced through chemical or UV/radiation mutagenesis. However, organisms generated through gene editing, including microalgae, where only genetic changes in native genes are made, remain currently under the GMO umbrella; they are, as such, excluded from practical and commercial opportunities in the EU. In this review, we will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GM microalgae in Europe.

Integrated and Translational Nonclinical In Vivo Cardiovascular Risk Assessment: Gaps and Opportunities

EPA Science Inventory

Cardiovascular (CV) safety concerns are a significant source of drug development attrition in the pharmaceutical industry today. Though current nonclinical testing paradigms have largely prevented catastrophic CV events in Phase I studies, many challenges relating to the inabil...

Developing and Evaluating New Methods for Assessing Concurrent Environmental Exposures

EPA Science Inventory

Summary of purpose and scope (no longer than 200 words): One limitation to current environmental health research is the focus on single contaminant exposures. Each exposure estimated in epidemiologic models accounts for a relatively small proportion of observed variance in health...

Freight from space : evaluating freight activity and emissions from satellite data.

DOT National Transportation Integrated Search

2013-06-01

In this report, the authors investigate the current state of knowledge of freight transport emissions, the importance of freight emissions relative to other sources, and what tools are available, or can be developed to answer these questions and impr...

Expert and Knowledge Based Systems.

ERIC Educational Resources Information Center

Demaid, Adrian; Edwards, Lyndon

1987-01-01

Discusses the nature and current state of knowledge-based systems and expert systems. Describes an expert system from the viewpoints of a computer programmer and an applications expert. Addresses concerns related to materials selection and forecasts future developments in the teaching of materials engineering. (ML)

UPDATE ON EPA'S URBAN WATERSHED MANAGEMENT BRANCH MODELING ACTIVITIES

EPA Science Inventory

This paper provides the Stormwater Management Model (SWMM) user community with a description of the Environmental Protection Agency (EPA's) Office of Research and Development (ORD) approach to urban watershed modeling research and provides an update on current ORD SWMM-related pr...

Developing a national strategic plan for consumer horticulture

USDA-ARS?s Scientific Manuscript database

Consumer Horticulture encompasses a wide-array of activities that are practiced by and of interest to the gardening public, garden-focused non-governmental organizations, and gardening-related industries. In a previous publication, we described the current lack of funding support for research, exten...

Teaching English Phrases through SMS

ERIC Educational Resources Information Center

Cig, Enes Kurtay; Guvercin, Selim; Bayimbetov, Berdak; Dos, Bulent

2015-01-01

Achieving the maximum efficiency in teaching a second language (L2) has always been an important issue for educators. Current globalization processes, development of international business relations, political integrations among the various countries throughout the world, and the abilities of latest information and communications technologies…

Pharmacologic Treatment of Wet Type Age-related Macular Degeneration; Current and Evolving Therapies.

PubMed

Shams Najafabadi, Hoda; Daftarian, Narsis; Ahmadieh, Hamid; Soheili, Zahra-Soheila

2017-08-01

Age-related macular degeneration as the major cause of blindness in the elderly population has remained at the epicenter of clinical research in ophthalmology. This retinal disorder is characterized by the photoreceptor and retinal pigment epithelial cells loss, occurring within the macula. The disease represents a spectrum of clinical manifestations. It is a multifactorial disease resulting from a combination of genetic predispositions and environmental risk factors. AMD is classified into two different types, dry and wet. Wet AMD is in close relation with angiogenesis and inflammatory processes.A variety of anti-angiogenesis and anti-inflammatory drugs have been proposed for the treatment of the disease. The purpose of this paper is to briefly review the pharmacological therapies of the wet form of AMD and focus on new drugs that are currently in different stages of research and development.

Prevention and treatment of exercise related leg pain in young soldiers; a review of the literature and current practice in the Dutch Armed Forces.

PubMed

Zimmermann, Wes O; Helmhout, P H; Beutler, A

2017-04-01

Overuse injuries of the leg are a common problem for young soldiers. This article reviews the literature concerning the prevention and treatment of exercise related leg pain in military settings and presents the latest developments in proposed mechanisms and treatments. Current practice and treatment protocols from the Dutch Armed Forces are reviewed, with an emphasis on the most prevalent conditions of medial tibial stress syndrome and chronic exertional compartment syndrome. The conclusion is that exercise related leg pain in the military is an occupational problem that deserves further study. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features

PubMed Central

Kamarajan, Chella; Pandey, Ashwini K.; Chorlian, David B.; Manz, Niklas; Stimus, Arthur T.; Anokhin, Andrey P.; Bauer, Lance O.; Kuperman, Samuel; Kramer, John; Bucholz, Kathleen K.; Schuckit, Marc A.; Hesselbrock, Victor M.; Porjesz, Bernice

2015-01-01

Background Individuals at high risk to develop alcoholism often manifest neurocognitive deficits as well as increased impulsivity. Event-related oscillations (EROs) have been used to effectively measure brain (dys)function during cognitive tasks in individuals with alcoholism and related disorders and in those at risk to develop these disorders. The current study examines ERO theta power during reward processing as well as impulsivity in adolescent and young adult subjects at high risk for alcoholism. Methods EROs were recorded during a monetary gambling task (MGT) in 12–25 years old participants (N = 1821; males = 48%) from high risk alcoholic families (HR, N = 1534) and comparison low risk community families (LR, N = 287) from the Collaborative Study on the Genetics of Alcoholism (COGA). Impulsivity scores and prevalence of externalizing diagnoses were also compared between LR and HR groups. Results HR offspring showed lower theta power and decreased current source density (CSD) activity than LR offspring during loss and gain conditions. Younger males had higher theta power than younger females in both groups, while the older HR females showed more theta power than older HR males. Younger subjects showed higher theta power than older subjects in each comparison. Differences in topography (i.e., frontalization) between groups were also observed. Further, HR subjects across gender had higher impulsivity scores and increased prevalence of externalizing disorders compared to LR subjects. Conclusions As theta power during reward processing is found to be lower not only in alcoholics, but also in HR subjects, it is proposed that reduced reward-related theta power, in addition to impulsivity and externalizing features, may be related in a predisposition to develop alcoholism and related disorders. PMID:26580209

Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features.

PubMed

Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B; Manz, Niklas; Stimus, Arthur T; Anokhin, Andrey P; Bauer, Lance O; Kuperman, Samuel; Kramer, John; Bucholz, Kathleen K; Schuckit, Marc A; Hesselbrock, Victor M; Porjesz, Bernice

2015-01-01

Individuals at high risk to develop alcoholism often manifest neurocognitive deficits as well as increased impulsivity. Event-related oscillations (EROs) have been used to effectively measure brain (dys)function during cognitive tasks in individuals with alcoholism and related disorders and in those at risk to develop these disorders. The current study examines ERO theta power during reward processing as well as impulsivity in adolescent and young adult subjects at high risk for alcoholism. EROs were recorded during a monetary gambling task (MGT) in 12-25 years old participants (N = 1821; males = 48%) from high risk alcoholic families (HR, N = 1534) and comparison low risk community families (LR, N = 287) from the Collaborative Study on the Genetics of Alcoholism (COGA). Impulsivity scores and prevalence of externalizing diagnoses were also compared between LR and HR groups. HR offspring showed lower theta power and decreased current source density (CSD) activity than LR offspring during loss and gain conditions. Younger males had higher theta power than younger females in both groups, while the older HR females showed more theta power than older HR males. Younger subjects showed higher theta power than older subjects in each comparison. Differences in topography (i.e., frontalization) between groups were also observed. Further, HR subjects across gender had higher impulsivity scores and increased prevalence of externalizing disorders compared to LR subjects. As theta power during reward processing is found to be lower not only in alcoholics, but also in HR subjects, it is proposed that reduced reward-related theta power, in addition to impulsivity and externalizing features, may be related in a predisposition to develop alcoholism and related disorders.

The Role of Inflation and Price Escalation Adjustments in Properly Estimating Program Costs: F-35 Case Study

DTIC Science & Technology

2016-03-01

regression models that yield hedonic price indexes is closely related to standard techniques for developing cost estimating relationships ( CERs ...October 2014). iii analysis) and derives a price index from the coefficients on variables reflecting the year of purchase. In CER development, the...index. The relevant cost metric in both cases is unit recurring flyaway (URF) costs. For the current project, we develop a “Baseline” CER model, taking

Differential Acquisition of Lever Pressing in Inbred and Outbred Mice: Comparison of One-Lever and Two-Lever Procedures and Correlation with Differences in Locomotor Activity

ERIC Educational Resources Information Center

McKerchar, Todd L.; Zarcone, Troy J.; Fowler, Stephen C.

2005-01-01

Recent progress in mouse genetics has led to an increased interest in developing procedures for assessing mouse behavior, but relatively few of the behavioral procedures developed involve positively reinforced operant behavior. When operant methods are used, nose poking, not lever pressing, is the target response. In the current study differential…

Critical Professional Issues in Labour Force Development for Teachers with Children up to Two Years of Age: A New Zealand Perspective

ERIC Educational Resources Information Center

Rockel, Jean

2014-01-01

This paper critically examines current concerns regarding professional issues in labour force development for teachers with children up to two years of age (UtoT). The concerns in New Zealand (NZ) relate to whether initial teacher-education (ITE) qualifications prepare teachers to work with children UtoT, involving synergy between ITE and the…

Leveraging Facebook to Brand Radiology.

PubMed

Tso, Hilda H; Parikh, Jay R

2018-03-30

In the current health care climate, radiologists should consider developing their brand. Facebook is the market leader for social media networking in the United States. The authors describe how radiologists can leverage Facebook to develop and market organizational, group, and individual brands. The authors then address concerns related to the use of social media by radiologists. Copyright © 2018 American College of Radiology. Published by Elsevier Inc. All rights reserved.

ELT in Development Aid: Defining Aims and Measuring Results. Dunford House Seminar Report (England, United Kingdom, July 18-29, 1988).

ERIC Educational Resources Information Center

British Council, London (England).

Proceedings of a seminar on the role of English second language (ELT) training in British technical assistance projects for economic development are presented in the form of a brief analysis of current issues and concerns to participants, a summary of the conference, and related appended materials. This conference focused on defining project…

Management Development.

DTIC Science & Technology

1972-12-01

and inte- grating increasing numbers of specialists. For example, Information technology Is a relatively new development which has led to the creation...changes occurring in technology that require new information to be disseminated to all the managers whose jobs will be affected by the new technology . It is...requires an analysis of current and future needs of the manager and his organization. Information about alternatives or their discovery requires that

Geometry-Based Observability Metric

NASA Technical Reports Server (NTRS)

Eaton, Colin; Naasz, Bo

2012-01-01

The Satellite Servicing Capabilities Office (SSCO) is currently developing and testing Goddard s Natural Feature Image Recognition (GNFIR) software for autonomous rendezvous and docking missions. GNFIR has flight heritage and is still being developed and tailored for future missions with non-cooperative targets: (1) DEXTRE Pointing Package System on the International Space Station, (2) Relative Navigation System (RNS) on the Space Shuttle for the fourth Hubble Servicing Mission.

Universities, Public Priorities, and the Future of Ontario. A Brief to the Standing Committee on Social Development of the Legislature of Ontario. Publication No. 83-9.

ERIC Educational Resources Information Center

Council of Ontario Universities, Toronto.

This brief was submitted to the Standing Committee on Social Development of the Ontario Legislature in connection with Bill 42, which is intended to limit university deficits. The following concerns are examined: current university funding levels in relation to enrollment and student demand, research responsibilities, tuition fee levels, and…

Development and Testing of Space Fission Technology at NASA-MSFC

NASA Technical Reports Server (NTRS)

Polzin, Kurt; Pearson, J. Boise; Houts, Michael

2008-01-01

The Early Flight Fission Test Facility (EFF-TF) at NASA-Marshall Space Flight Center (MSFC) provides a capability to perform hardware-directed activities to support multiple inspace nuclear reactor concepts by using a non-nuclear test methodology. This includes fabrication and testing at both the module/component level and near prototypic reactor configurations allowing for realistic thermal-hydraulic evaluations of systems. The EFF-TF is currently performing non-nuclear testing of hardware to support a technology development effort related to an affordable fission surface power (AFSP) system that could be deployed on the Lunar surface. The AFSP system is presently based on a pumped liquid metal-cooled reactor design, which builds on US and Russian space reactor technology as well as extensive US and international terrestrial liquid metal reactor experience. An important aspect of the current hardware development effort is the information and insight that can be gained from experiments performed in a relevant environment using realistic materials. This testing can often deliver valuable data and insights with a confidence that is not otherwise available or attainable. While the project is currently focused on potential fission surface power for the lunar surface, many of the present advances, testing capabilities, and lessons learned can be applied to the future development of a low-cost in-space fission power system. The potential development of such systems would be useful in fulfilling the power requirements for certain electric propulsion systems (magnetoplasmadynamic thruster, high-power Hall and ion thrusters). In addition, inspace fission power could be applied towards meeting spacecraft and propulsion needs on missions further from the Sun, where the usefulness of solar power is diminished. The affordable nature of the fission surface power system that NASA may decide to develop in the future might make derived systems generally attractive for powering spacecraft and propulsion systems in space. This presentation will discuss work on space nuclear systems that has been performed at MSFC's EFF-TF over the past 10 years. Emphasis will be place on both ongoing work related to FSP and historical work related to in-space systems potentially useful for powering electric propulsion systems.